Sample records for mapp miso mro

  1. QER- Comment of MISO

    Broader source: Energy.gov [DOE]

    The Midcontinent Independent System Operator, Inc. (MISO), respectfully submits two studies to the Department of Energy (DOE) for consideration in preparing its Quadrennial Energy Review (QER) on transmission, storage and distribution infrastructure. MISO also presented to DOE on the QER at the Newark, NJ public session held on September 8, 2014. MISO appreciates that opportunity. In addition to the material presented in Newark, MISO recently completed two studies on transmission and energy storage in the MISO footprint, which covers all or parts of 15 states in the middle of the Unites States.

  2. mushroom-miso-gravy

    E-Print Network [OSTI]

    Date: Fri, 26 Nov 93 00:52:36 PST From: Michelle Dick TANGY MUSHROOM MISO GRAVY 1 lb mushrooms 1 T balsamic vinegar 3 cups water 1

  3. Bargaining and the MISO Interference Channel

    E-Print Network [OSTI]

    Nokleby, Matthew; Swindlehurst, A. Lee

    2009-01-01T23:59:59.000Z

    the pareto boundary for the MISO interference channel,” IEEEinterference in the Gaussian MISO broadcast channel,” inOn maximizing the sum network MISO broadcast capacity,” in

  4. Distributed Interference Pricing with MISO Channels

    E-Print Network [OSTI]

    Kuzmanovic, Aleksandar

    Distributed Interference Pricing with MISO Channels Changxin Shi, Randall A. Berry, and Michael L an interference channel consisting of multi- input, single-output (MISO) wireless links. The objective generalized to a MISO network, as shown in Sec- tion II. Such an algorithm was previously presented in [3

  5. Optimization of Energy Harvesting MISO Communication Channels

    E-Print Network [OSTI]

    Gesbert, David

    1 Optimization of Energy Harvesting MISO Communication Channels Rajeev Gangula, Student Member-to-point multiple-input single-output (MISO) communication system is con- sidered when both the transmitter (TX bound on the ergodic rate of MISO channel with beamforming and limited feedback. Feedback bit allocation

  6. Virtual MISO Triggers in Wi-Fi-like Networks

    E-Print Network [OSTI]

    Virtual MISO Triggers in Wi-Fi-like Networks Oscar Bejarano Edward W. Knightly 1 Thursday, April 11 difficult to achieve in mobile devices Thursday, April 11, 2013 #12;5 Virtual MISO (vMISO) TX RX vMISO, 2013 #12;1. System Model 1.1. Distributed System 1.2. Single-Antenna Nodes 6 vMISO

  7. Optimal Distributed Beamforming for MISO Interference Channels

    E-Print Network [OSTI]

    Qiu, Jiaming

    2012-07-16T23:59:59.000Z

    In this thesis, the problem of quantifying the Pareto optimal boundary of the achievable rate region is considered over multiple-input single-output(MISO)interference channels, where the problem boils down to solving a sequence of convex feasibility...

  8. Real-time MISO UWB Radio Testbed and Waveform Design

    E-Print Network [OSTI]

    Qiu, Robert Caiming

    Real-time MISO UWB Radio Testbed and Waveform Design Yu Song, Zhen Hu, Nan Guo, and Robert C. Qiu-input single-output (MISO) ultra-wideband (UWB) radio testbed, which involves Xinlix Virtex-5 Field in indoor environment. The transmitted MISO signals are optimized in the passband with a bandwidth up to 500

  9. Robust Secure Transmission in MISO Channels With Imperfect ECSI

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    Robust Secure Transmission in MISO Channels With Imperfect ECSI Jing Huang and A. Lee Swindlehurst.huang; swindle}@uci.edu Abstract--This paper studies robust transmission schemes for MISO wiretap channels-input single-output (MISO) wiretap cannels, the optimal transmit covariance matrix was found to be single

  10. Blind Channel Estimation for Orthogonal STBC in MISO Systems

    E-Print Network [OSTI]

    Adve, Raviraj

    1 Blind Channel Estimation for Orthogonal STBC in MISO Systems Elzbieta Beres, and Raviraj Adve-input single-output (MISO) systems, with specific focus on Alamouti's code for two transmit antennas of the received signal. Unlike previous blind estimation schemes for MISO systems, the proposed algorithm

  11. Secure MISO Cognitive Radio System with Perfect and Imperfect CSI

    E-Print Network [OSTI]

    Wong, Vincent

    Secure MISO Cognitive Radio System with Perfect and Imperfect CSI Taesoo Kwon, Vincent W.S. Wong eavesdrop on the primary link. This paper explores multiple-input single-output (MISO) CR systems where a multiple- input single-output (MISO) beamforming algorithm for the secondary system. However, it only

  12. MISO Broadcast Channels with Confidential Messages and Alternating CSIT

    E-Print Network [OSTI]

    Ulukus, Sennur

    MISO Broadcast Channels with Confidential Messages and Alternating CSIT Pritam Mukherjee1 , Ravi, Blacksburg, VA 24061 Abstract--We study the two-user multiple-input single-output (MISO) broadcast channel-user multiple- input single-output (MISO) broadcast channel with confiden- tial messages (BCCM), in which

  13. Optimizing Feedback in Energy Harvesting MISO Communication Channels

    E-Print Network [OSTI]

    Gesbert, David

    Optimizing Feedback in Energy Harvesting MISO Communication Channels Rajeev Gangula1 , David.gunduz@imperial.ac.uk Abstract--In this work,1 we consider the optimization of feedback in a point-to-point MISO channel in the context of a simple multiple antenna system, namely MISO channel, where feedback can be used to improve

  14. Optimal MU-MIMO precoder with MISO decomposition approach

    E-Print Network [OSTI]

    Gesbert, David

    Optimal MU-MIMO precoder with MISO decomposition approach Mustapha Amara, Yi Yuan-Wu Orange Labs considered the best existing precoder design algorithm for a MISO multiuser sys- tem proposed in [1 procedure transforming the MU-MIMO channel for each iteration into a MU-MISO channel trough virtual channel

  15. BLIND RECEIVERS FOR MISO COMMUNICATION SYSTEMS USING A NONLINEAR PRECODER

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    BLIND RECEIVERS FOR MISO COMMUNICATION SYSTEMS USING A NONLINEAR PRECODER Alain Y. Kibangou GIPSA.Kibangou@ujf-grenoble.fr ABSTRACT In this paper, we propose two blind decoding approaches for multi-input single-output (MISO of simulations. 1. INTRODUCTION Multi-input Single Output (MISO) communication channel modelling occurs when

  16. MISO Broadcast Channel with Delayed and Evolving CSIT

    E-Print Network [OSTI]

    Gesbert, David

    MISO Broadcast Channel with Delayed and Evolving CSIT Jinyuan Chen and Petros Elia Mobile--The work considers the two-user MISO broadcast channel with a gradual and delayed accumulation of channel-input single-output broadcast channel (MISO BC) with an M-transmit antenna (M 2) transmitter communicating

  17. MISO Broadcasting FBMC System for Highly Frequency Selective Channels

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    MISO Broadcasting FBMC System for Highly Frequency Selective Channels Michael Newinger, Leonardo G.a.nossek}@tum.de swindle@uci.edu Abstract--In this contribution we propose new techniques for multi-user MISO broadcasting an SDMA approach for the MISO broadcast channel based on Tomlinson-Harashima Precoding. However

  18. Distributed Precoding for MISO Interference Channels with Channel Mean Feedback

    E-Print Network [OSTI]

    Ulukus, Sennur

    Distributed Precoding for MISO Interference Channels with Channel Mean Feedback: Algorithms precoding algorithms for multiple-input single-output (MISO) interference channels, where each trans- mitter- antenna wireless interference channels [5]-[7]. For multiple- input single-output (MISO) interference

  19. Dynamic System Performance of SISO, MISO and MIMO Alamouti Schemes

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Dynamic System Performance of SISO, MISO and MIMO Alamouti Schemes Dorra Ben Cheikh Battikh , Jean, coupecho, godlewski}@enst.fr Abstract--In this paper, the performance of a SISO system, a 2 × 1 MISO multiplexing tradeoff for a 2 × 1 MISO system. Many other techniques have been proposed to exploit antennas

  20. SINR Balancing and Beamforming for the MISO Interference Channel

    E-Print Network [OSTI]

    Gesbert, David

    SINR Balancing and Beamforming for the MISO Interference Channel Francesco Negro, Martina Cardone.negro@eurecom.fr, dirk.slock@eurecom.fr Abstract--In this paper a K user multi-input single-output (MISO) interference noise contribution (Noisy IFC). We address the MISO downlink (DL) beamformer design and power allocation

  1. Software agents : an application to the airline MRO industry

    E-Print Network [OSTI]

    Poon, Arthur Wai Keong, 1979-

    2004-01-01T23:59:59.000Z

    Poor management of aircraft spare parts, human-related maintenance errors and the lack of coordinated decision-making in maintenance scheduling are some of the problems plaguing the airline MRO industry. Airlines, independent ...

  2. Modeling, Analysis, Predictions, and Projections Email: oar.cpo.mapp@noaa.gov

    E-Print Network [OSTI]

    Earth system models to better simulate the climate system? Can we improve intraseasonal to seasonal mission, MAPP supports the development of advanced Earth system models that can predict climate variations, and the external research community. MAPP Objectives · Improve Earth system models · Achieve an integrated Earth

  3. Beyound 4G : (), () Trends and Advances in Multi-Cell MISO/MIMO

    E-Print Network [OSTI]

    Sung, Youngchul

    Beyound 4G : (), () , , Trends and Advances in Multi-Cell MISO/MIMO Technologies LTE-Advanced Beyond 4G . , (multiple-input single-output, MISO) (multiple-input multiple-output, MIMO) , MISO MIMO . . 3G , 4 LTE

  4. Proof of the outage probability conjecture for MISO channels

    E-Print Network [OSTI]

    Abbe, Emmanuel; Telatar, Emre

    2011-01-01T23:59:59.000Z

    In Telatar 1999, it is conjectured that the covariance matrices minimizing the outage probability for MIMO channels with Gaussian fading are diagonal with either zeros or constant values on the diagonal. In the MISO setting, this is equivalent to conjecture that the Gaussian quadratic forms having largest tale probability correspond to such diagonal matrices. We prove here the conjecture in the MISO setting.

  5. Subcarrier Clustering for MISO-OFDM Channels with Quantized Beamforming

    E-Print Network [OSTI]

    Santipach, - Wiroonsak

    Subcarrier Clustering for MISO-OFDM Channels with Quantized Beamforming Kritsada Mamat the capacity [1] and link reliability. Thus, many current and future wireless standards are based on multiple antenna. For a multiple-input single-output (MISO) channel, beamforming is a simple and effective method

  6. Distributed multicell-MISO precoding using the layered virtual SINR framework

    E-Print Network [OSTI]

    Gesbert, David

    1 Distributed multicell-MISO precoding using the layered virtual SINR framework Randa Zakhour, way in which the multicell MISO precoders may be designed at each BS in a distributed manner Pareto optimal rates for the MISO Interference Channel (IC); its extension to the multicell MISO channel

  7. Find your winning position in the MRO game

    E-Print Network [OSTI]

    Keep them flying Find your winning position in the MRO game Aerospace and Defense IBM Institute currently holds an inventory of about US$44 billion and supports an active global fleet of nearly 17 percent of their total expenditures. (Fuel and labor are other big expenses.) 6 Airlines spend an average

  8. Optimal Distributed Beamforming for MISO Interference Channels

    E-Print Network [OSTI]

    Qiu, Jiaming; Luo, Zhi-Quan; Cui, Shuguang

    2010-01-01T23:59:59.000Z

    We consider the problem of quantifying the Pareto optimal boundary in the achievable rate region over multiple-input single-output (MISO) interference channels, where the problem boils down to solving a sequence of convex feasibility problems after certain transformations. The feasibility problem is solved by two new distributed optimal beamforming algorithms, where the first one is to parallelize the computation based on the method of alternating projections, and the second one is to localize the computation based on the method of cyclic projections. Convergence proofs are established for both algorithms.

  9. Enhanced tumor responses through therapies combining CCNU, MISO and radiation

    SciTech Connect (OSTI)

    Siemann, D.W.; Hill, S.A.

    1984-09-01T23:59:59.000Z

    Studies were performed to determine whether the radiation sensitizer misonidazole (MISO) could enhance the tumor control probability in a treatment strategy combining radiation and the nitrosourea 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU). In initial experiments KHT sarcoma-bearing mice were injected with 1.0 mg/g of MISO simultaneously with a 20 mg/kg dose of CCNU 30-40 min prior to irradiation (1500 rad). With this treatment protocol approximately 60% of the mice were found to be tumor-free 100 days post treatment. By comparison all 2 agent combinations led to 0% cures. To evaluate the relative importance of chemopotentiation versus radiosensitization in the 3 agent protocol, tumors were treated with MISO plus one anti-tumor agent (either radiation of CCNU) and then at times ranging from 0 to 24 hr later exposed to the other agent. When the time between treatments was 0 to 6 hr, a 60 to 80% tumor control rate was achieved for both MISO plus radiation followed by CCNU and MISO plus CCNU followed by radiation. However if the time interval was increased to 18 or 24 hr, the cure rate in the former treatment regimen dropped to 10% while that of the latter remained high at 40%. The data therefore indicate that (1) improved tumor responses may be achieved when MISO is added to a radiation-chemotherapy combination and (2) MISO may be more effective in such a protocol when utilized as a chemopotentiator.

  10. Finite blocklength analysis of the MISO Coherent Block Fading Channel

    E-Print Network [OSTI]

    Collins, Austin Daniel

    2014-01-01T23:59:59.000Z

    The Coherent MISO Block Fading Channel is a wireless communication channel model in which the transmitter has access to multiple antennas while the receiver has access to one. This model is becoming increasingly important ...

  11. MAPP 7.10 -Procedures for Standardized Training in Animal Care & Use I Training Program

    E-Print Network [OSTI]

    Sinnamon, Gordon J.

    MAPP 7.10 - Procedures for Standardized Training in Animal Care & Use I Training Program 1. On behalf of the AUS, the ACVS Research Education Team will: 1.1 Develop appropriate training programs with reference to CCAC requirements; 1.2 Assess the training requirements of all personnel at the University

  12. Online Policies for Opportunistic Virtual MISO Routing in Wireless Ad Hoc Networks

    E-Print Network [OSTI]

    Rossi, Michele

    Online Policies for Opportunistic Virtual MISO Routing in Wireless Ad Hoc Networks Cristiano in virtual multiple input single output (MISO) trans- missions and space-time block codes have been proposed

  13. Spatial Interference Mitigation for Multiple Input Multiple Output Ad Hoc Networks: MISO Gains

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Spatial Interference Mitigation for Multiple Input Multiple Output Ad Hoc Networks: MISO Gains beamforming for a multiple input single output (MISO) ad hoc network to increase the density of successful

  14. Large System Analysis of Zero-Forcing Precoding in MISO Broadcast Channels with Limited

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Large System Analysis of Zero-Forcing Precoding in MISO Broadcast Channels with Limited Feedback in MISO broadcast channels with limited feed- back, transmit correlation and path loss. Our analysis

  15. Virtual MISO Triggers in WiFi-like Networks Oscar Bejarano and Edward W. Knightly

    E-Print Network [OSTI]

    Knightly, Edward W.

    Virtual MISO Triggers in WiFi-like Networks Oscar Bejarano and Edward W. Knightly ECE Department, Rice University, Houston, TX 77005 Technical Report Abstract--Virtual Multiple-Input Single-Output (vMISO) sys- tems distribute multi-antenna diversity capabilities between a sending and a cooperating node. vMISO

  16. Time Reversal with MISO for Ultra-Wideband Communications: Experimental Results (invited paper)

    E-Print Network [OSTI]

    Qiu, Robert Caiming

    TH2B-1 Time Reversal with MISO for Ultra-Wideband Communications: Experimental Results (invited Output (MISO) is enabled by the use of the TR scheme. Two basic problems are investigated experimentally for the first time in electromagnetics. Index Terms -- TR, MISO, UWB, channel reciprocity. I. INTRODUCTION UWB

  17. Weighted Sum Rate Maximization of Correlated MISO Broadcast Channels under Linear Precoding

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Weighted Sum Rate Maximization of Correlated MISO Broadcast Channels under Linear Precoding algorithm proposed by Christensen et al. in large correlated MISO broadcast channels. We propose a novel maximization. I. INTRODUCTION WE consider the multiple-input single-output (MISO) broadcast channel (BC

  18. On Duality in the MISO Interference Channel Francesco Negro, Irfan Ghauri, Dirk T.M. Slock

    E-Print Network [OSTI]

    Gesbert, David

    On Duality in the MISO Interference Channel Francesco Negro, Irfan Ghauri, Dirk T.M. Slock Infineon in a multi-input single- output (MISO) interference channel (IFC) and its dual SIMO with linear transmit (Tx for the IFC. We show that SINR duality under the sum power constraint nevertheless holds in the MISO IFC

  19. Beamforming in MISO Systems: Empirical Results and EVM-based Analysis

    E-Print Network [OSTI]

    1 Beamforming in MISO Systems: Empirical Results and EVM-based Analysis Melissa Duarte, Ashutosh-based study of beamforming Multiple Input Single Output (MISO) systems. We analyze the performance of beamforming MISO systems taking into account implementation complexity and effects of imperfect channel

  20. Asymptotic Analysis of Regularized Zero-Forcing Precoding in MISO Broadcast Channels

    E-Print Network [OSTI]

    Boyer, Edmond

    Asymptotic Analysis of Regularized Zero-Forcing Precoding in MISO Broadcast Channels with Limited analyse the asymptotic sum-rate of regularized zero-forcing (RZF) precoding in MISO broadcast channels equivalent of mfK @zA. III. SYSTEM MODEL Consider the MISO broadcast channel composed of one central

  1. Virtual MISO Triggers in Wi-Fi-like Networks Oscar Bejarano and Edward W. Knightly

    E-Print Network [OSTI]

    Knightly, Edward W.

    Virtual MISO Triggers in Wi-Fi-like Networks Oscar Bejarano and Edward W. Knightly ECE Department-Input Single-Output (vMISO) sys- tems distribute multi-antenna diversity capabilities between a sending and a cooperating node. vMISO has the potential to vastly improve wireless link reliability and bit error rates

  2. COMPRESSIVE INVERSE SCATTERING I. HIGH FREQUENCY SIMO/MISO AND MIMO MEASUREMENTS

    E-Print Network [OSTI]

    Fannjiang, Albert

    COMPRESSIVE INVERSE SCATTERING I. HIGH FREQUENCY SIMO/MISO AND MIMO MEASUREMENTS ALBERT C), multiple-input-single-output (MISO) or multiple-input-multiple-output (MIMO) measurements is analyzed of the data either with the MIMO measurement for the Born scattering or with the SIMO/MISO measurement

  3. Virtual MISO: Experimental Evaluation of MAC to Network-Scale Factors

    E-Print Network [OSTI]

    Virtual MISO: Experimental Evaluation of MAC to Network-Scale Factors Oscar Bejarano and Edward W-Input Single-Output (vMISO) sys- tems distribute multi-antenna diversity capabilities between a sending and a cooperating node. vMISO has been shown to vastly improve wireless link reliability and bit error rates

  4. A Robust RAM-THP Architecture for Downlink Multiuser MISO Transmission with User Scheduling

    E-Print Network [OSTI]

    Gulak, P. Glenn

    A Robust RAM-THP Architecture for Downlink Multiuser MISO Transmission with User Scheduling Saeed-Forcing Tomlinson-Harashima Precoding (ZF-THP) for multi-user trans- mission in a multiple-input-single-output (MU-MISO-THP, zero-forcing, multi- user MISO, precoding, scheduling. I. INTRODUCTION Multiple-Input Multiple

  5. Degrees of Freedom of Time Correlated MISO Broadcast Channel with Delayed CSIT

    E-Print Network [OSTI]

    Gesbert, David

    1 Degrees of Freedom of Time Correlated MISO Broadcast Channel with Delayed CSIT Sheng Yang, Member Abstract We consider the time correlated MISO broadcast channel where the transmitter has imperfect 0, we characterize the optimal degree of freedom region for this more general two-user MISO

  6. Degrees of Freedom of Time Correlated MISO Broadcast Channel with Delayed CSIT

    E-Print Network [OSTI]

    Gesbert, David

    1 Degrees of Freedom of Time Correlated MISO Broadcast Channel with Delayed CSIT Sheng Yang, Member Abstract We consider the time correlated MISO broadcast channel where the transmitter has imperfect characterize the optimal degree of freedom region for this more general two-user MISO broadcast correlated

  7. On the Fundamental Feedback-vs-Performance Tradeoff over the MISO-BC with Imperfect and

    E-Print Network [OSTI]

    Gesbert, David

    On the Fundamental Feedback-vs-Performance Tradeoff over the MISO-BC with Imperfect and Delayed--This work considers the multiuser multiple-input single-output (MISO) broadcast channel (BC), where. Specifically, this work provides a novel DoF region outer bound for the general K- user M ×1 MISO BC

  8. NON-CONVEX UTILITY MAXIMIZATION IN GAUSSIAN MISO BROADCAST AND INTERFERENCE CHANNELS

    E-Print Network [OSTI]

    Simeone, Osvaldo

    NON-CONVEX UTILITY MAXIMIZATION IN GAUSSIAN MISO BROADCAST AND INTERFERENCE CHANNELS M. Rossi, A. M- imization [1] or SINR balancing for the multiple-input single-output (MISO) BC [2], and thus solvable, MISO BC and IC WSRM with general convex power constraint. The proposed BB approach is based

  9. Energy Efficiency Analysis of MISO-OFDM Communication Systems Considering Power and Capacity Constraints

    E-Print Network [OSTI]

    Wang, Cheng-Xiang

    Energy Efficiency Analysis of MISO-OFDM Communication Systems Considering Power and Capacity efficiency of multi-input single-output and orthogonal frequency division multiplex- ing (MISO problem of MISO-OFDM communication systems, the minimum subchannel transmission power is analyzed

  10. Robust MMSE Tomlinson-Harashima Precoder for Multiuser MISO Downlink with Imperfect CSI

    E-Print Network [OSTI]

    Chockalingam, A.

    Robust MMSE Tomlinson-Harashima Precoder for Multiuser MISO Downlink with Imperfect CSI P Abstract--Non-linear precoding for the downlink of a multiuser MISO (multiple-input single-linear precoders in the lit- erature. Keywords ­ Multiuser MISO downlink, multiuser interference, imperfect CSI

  11. LINEAR SPACE-TIME PRECODING FOR RICIAN FADING MISO CHANNELS Mai Vu, Arogyaswami Paulraj

    E-Print Network [OSTI]

    Vu, Mai

    LINEAR SPACE-TIME PRECODING FOR RICIAN FADING MISO CHANNELS Mai Vu, Arogyaswami Paulraj Stanford, Australia Email: r.evans@ee.mu.oz.au ABSTRACT We study a space-time precoding technique for MISO wire- less in practice. In this paper, we study a particular space-time coding scheme with memory for Rician MISO

  12. Joint Power Control and Beamforming Codebook Design for MISO Channels under the Outage

    E-Print Network [OSTI]

    Yu, Wei

    Joint Power Control and Beamforming Codebook Design for MISO Channels under the Outage Criterion and beamforming codebooks for limited-feedback multiple-input single-output (MISO) wireless systems. The problem focuses on optimal design of single-user limited-feedback systems over multiple-input single-output (MISO

  13. COORDINATION ON THE MISO INTERFERENCE CHANNEL USING THE VIRTUAL SINR Randa Zakhour and David Gesbert

    E-Print Network [OSTI]

    Gesbert, David

    COORDINATION ON THE MISO INTERFERENCE CHANNEL USING THE VIRTUAL SINR FRAMEWORK Randa Zakhour antenna users, this corresponds to the so-called MISO IC considered among oth- ers in [1, 2). Assuming each transmitter has multiple antennas and each receiver a single antenna, the setting is the MISO

  14. Experimental Results on Multiple-Input Single-Output (MISO) Time Reversal for UWB

    E-Print Network [OSTI]

    Qiu, Robert Caiming

    Experimental Results on Multiple-Input Single-Output (MISO) Time Reversal for UWB Systems with multiple-input single- output (MISO) antennas over ultra-wideband (UWB) channels. In particular, temporal and spatial focusing as well as array gain are studied based on a (4 × 1) MISO scheme in an office environment

  15. Jamming Countermeasures for Multi-User MISO Broadcast Channels -a DoF perspective

    E-Print Network [OSTI]

    Buehrer, R. Michael

    Jamming Countermeasures for Multi-User MISO Broadcast Channels - a DoF perspective SaiDhiraj Amuru the multi-user multiple-input single-output (MISO) broadcast channel (BC) in the presence of jamming attacks is quantified in terms of the degrees-of-freedom (DoF) of the MISO BC under various assumptions regarding

  16. Efficient Computation of the Pareto Boundary for the MISO Interference Channel with Perfect CSI

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Efficient Computation of the Pareto Boundary for the MISO Interference Channel with Perfect CSI,erik.larsson}@isy.liu.se Abstract--We consider the two-user multiple-input single- output (MISO) interference channel and the rate of the IFC is called a multiple-input single-output (MISO) This work was supported in part by the Swedish

  17. FPGA Based UWB MISO Time-Reversal System Design and Implementation

    E-Print Network [OSTI]

    Qiu, Robert Caiming

    FPGA Based UWB MISO Time-Reversal System Design and Implementation Yu Song, Nan Guo, Zhen Hu and implementation of ultra-wideband (UWB) multiple-input single-output (MISO) time-reversal system are presented. The implementation is based on field programmable gate array (FPGA). The combination of MISO with UWB time

  18. UWB MISO Time Reversal With Energy Detector Receiver Over ISI Channels

    E-Print Network [OSTI]

    Qiu, Robert Caiming

    UWB MISO Time Reversal With Energy Detector Receiver Over ISI Channels Nan Guo, John Q. Zhang investigates a multiple input single output (MISO) time reversal system for ultra-wideband (UWB) communication channel model for antenna array related study. Numerical results suggest that the proposed MISO time

  19. Spatial and Temporal Power Allocation for MISO Systems with Delayed Feedback

    E-Print Network [OSTI]

    Bhashyam, Srikrishna

    Spatial and Temporal Power Allocation for MISO Systems with Delayed Feedback Venkata Sreekanta@ee.iitm.ac.in Abstract-- We determine the minimum outage probabil- ity of multiple-input single-output (MISO) channels control. I. INTRODUCTION The minimum outage probability of multiple-input single-output (MISO) channels

  20. A Cross-Layer Framework for Exploiting Virtual MISO Links in Mobile Ad Hoc Networks

    E-Print Network [OSTI]

    Krishnamurthy, Srikanth

    A Cross-Layer Framework for Exploiting Virtual MISO Links in Mobile Ad Hoc Networks Gentian requiring the deployment of physical antenna arrays. Virtual MISO entails the simultaneous transmission. We present a novel multilayer approach for exploiting virtual MISO links in ad hoc networks

  1. Optimization of Feedback in a MISO Downlink with Energy Harvesting Users

    E-Print Network [OSTI]

    Uysal-Biyikoglu, Elif

    Optimization of Feedback in a MISO Downlink with Energy Harvesting Users Mahdi Shakiba channel states) in order to maximize certain throughput goals. While the MISO chan- nel capacity from to the energy budget of the users. Note that in the Multi Input Single Output (MISO) channel (with m antennas

  2. QoS-Constrained Robust Beamforming in MISO Wiretap Channels with a Helper

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    QoS-Constrained Robust Beamforming in MISO Wiretap Channels with a Helper Jing Huang and A. Lee for multiple-input single-output (MISO) wiretap chan- nels with a helper. The channel state information (CSI]­[8]. In particular, for multiple-input single-output (MISO) wiretap channels, the optimal transmit covariance matrix

  3. Beamforming on the MISO interference channel with multi-user decoding capability

    E-Print Network [OSTI]

    Gesbert, David

    1 Beamforming on the MISO interference channel with multi-user decoding capability K. M. Ho , D,mochaourab}@ifn.et.tu-dresden.de Abstract-- This paper considers the multiple-input- single-output interference channel (MISO-IC) in which the received signal. On the MISO-IC with single user decoding, transmit beamforming vectors are designed

  4. IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS, VOL. 5, 2006 1 Time Reversal With MISO for Ultrawideband

    E-Print Network [OSTI]

    Qiu, Robert Caiming

    IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS, VOL. 5, 2006 1 Time Reversal With MISO applications. UWB multiple input­single output (MISO) is enabled by the use of the TR scheme. Two basic. Index Terms--Channel reciprocity, multiple input­single output (MISO), time reversal (TR), ultrawideband

  5. ON THE USAGE OF ANTENNAS IN MIMO AND MISO INTERFERENCE CHANNELS Mariam Kaynia

    E-Print Network [OSTI]

    Gesbert, David

    ON THE USAGE OF ANTENNAS IN MIMO AND MISO INTERFERENCE CHANNELS Mariam Kaynia , Andrea J. Goldsmith case of a MISO chan- nel is considered, where exact expressions for the ergodic capac- ity of the capacity of a MISO broadcast channel with a random beamformer is derived. However, the impact

  6. BLIND CHANNEL IDENTIFICATION OF MISO SYSTEMS BASED ON THE CP DECOMPOSITION OF CUMULANT TENSORS

    E-Print Network [OSTI]

    BLIND CHANNEL IDENTIFICATION OF MISO SYSTEMS BASED ON THE CP DECOMPOSITION OF CUMULANT TENSORS algorithm for identifying the parameters of MISO sys- tem. 1. INTRODUCTION We consider the following-Input Single-Output (MISO) channel, y[n] is the output signal. Signals and system are assumed to be complex

  7. Coordination on the MISO Interference Channel Using the Virtual SINR Framework

    E-Print Network [OSTI]

    Gesbert, David

    Coordination on the MISO Interference Channel Using the Virtual SINR Framework Randa Zakhour David;Outline Motivation Cooperation in multi-cell/link systems MISO IC System Model and Performance Measures Motivation Cooperation in multi-cell/link systems MISO IC System Model and Performance Measures Virtual SINR

  8. IEEE TRANSACTIONS ON INFORMATION THEORY, VOL. 60, NO. 6, JUNE 2014 3593 Retroactive Antijamming for MISO

    E-Print Network [OSTI]

    Buehrer, R. Michael

    for MISO Broadcast Channels SaiDhiraj Amuru, Student Member, IEEE, Ravi Tandon, Member, IEEE, Richard and increased power consumption. In this paper, we consider the multiple-input single-output (MISO) broadcastF) of the MISO BC under various assumptions regarding the availability of the channel state information (CSIT

  9. Beamforming for the Underlay Cognitive MISO Interference Channel via UL-DL Duality

    E-Print Network [OSTI]

    Gesbert, David

    Beamforming for the Underlay Cognitive MISO Interference Channel via UL-DL Duality Francesco Negro.negro@eurecom.fr, dirk.slock@eurecom.fr Abstract--SINR duality is shown in a multi-input single- output (MISO) downlink for the IFC. We show that SINR duality under the sum power constraint nevertheless holds in the MISO IFC

  10. BEAMFORMING MAXIMIZES THE MISO COMPOUND CAPACITY Ami Wiesel, Yonina C. Eldar and Shlomo Shamai (Shitz)

    E-Print Network [OSTI]

    Eldar, Yonina

    BEAMFORMING MAXIMIZES THE MISO COMPOUND CAPACITY Ami Wiesel, Yonina C. Eldar and Shlomo Shamai for exploiting this multiple in- put single output (MISO) channel are space time coding, and beamforming (BF]. The capacity achieving transmit technique in MISO chan- nels with additive Gaussian noise is signaling using

  11. Closed Loop System with Feedback Control MISO control laws SISO control law

    E-Print Network [OSTI]

    Ben-Yakar, Adela

    Closed Loop System with Feedback Control MISO control laws SISO control law Switching Control demand · Two control modes for wind turbine: MISO & SISO · Proportional Integral (PI) feedback control Modes MISO SISO Inputs Blade Pitch Angle, Generator Torque Blade Pitch Angle Output Power Power

  12. ICI Canceling Space-Frequency Block Code for MISO-OFDM in Fast Fading Channels

    E-Print Network [OSTI]

    Lee, Yong Hoon

    ICI Canceling Space-Frequency Block Code for MISO-OFDM in Fast Fading Channels Jae Yeun Yun, Eui}@ee.kaist.ac.kr Abstract-- An intercarrier interference (ICI) canceling technique for multiple-input single-output (MISO) at the receiver for multiple-input single-output (MISO) systems. The code design is based on the approximated

  13. Distributed Interference Pricing with MISO Changxin Shi, Randall A. Berry, and Michael L. Honig

    E-Print Network [OSTI]

    Honig, Michael L.

    Distributed Interference Pricing with MISO Channels Changxin Shi, Randall A. Berry, and Michael L an interference channel consisting of multi-input, single- output (MISO) wireless links. The objective] can be directly generalized to a MISO network, as shown in Section II. Such an algorithm

  14. Joint Power Control and Beamforming Codebook Design for MISO Channels with Limited Feedback

    E-Print Network [OSTI]

    Yu, Wei

    Joint Power Control and Beamforming Codebook Design for MISO Channels with Limited Feedback Behrouz-input single-output (MISO) wireless systems with a rate-limited feedback link. The problem is cast in the form-output (MISO) channel with channel state information at the receiver (CSIR) and a noiseless delay-free feedback

  15. Weighted Sum Rate Maximization in the Underlay Cognitive MISO Interference Channel

    E-Print Network [OSTI]

    Gesbert, David

    Weighted Sum Rate Maximization in the Underlay Cognitive MISO Interference Channel Laurent Gallo) maximization for a K-user Multiple-Input Single-Output (MISO) cognitive Interference Channel (IFC) with linear studied in a non-cognitive scenario for the MISO inter- ference channel (IFC) in [3], where a distributed

  16. Outage Probability of MISO Broadcast Systems with Noisy Channel Side Information

    E-Print Network [OSTI]

    Lim, Teng Joon

    Outage Probability of MISO Broadcast Systems with Noisy Channel Side Information Alon Shalev output (MISO) systems. However, these schemes generally require perfect channel information) of a linear zero forcing transmitter, operating in a fading MISO broadcast channel. We consider a rectangular

  17. Mean-Variance Optimal Linear Precoders for Random MISO Broadcast Channels

    E-Print Network [OSTI]

    Lim, Teng Joon

    Mean-Variance Optimal Linear Precoders for Random MISO Broadcast Channels Alon Shalev Housfater the problem of designing linear pre- coders for Gaussian multiple input, single output (MISO) broad- cast (BC and constraint functions. I. INTRODUCTION Random MISO BC channels are powerful models for the practical scenario

  18. MISO time reversal and delay spread compression for FWA channels at 5GHz

    E-Print Network [OSTI]

    Papanicolaou, George C.

    MISO time reversal and delay spread compression for FWA channels at 5GHz Persefoni Kyritsi, Member (MISO) can reduce the delay spread of the channel impulse response by a factor of 2-3, depending transmitter instead. The paper is structured as follows. Section II describes the concept of TR in a MISO

  19. Experimental Demonstration of Time-Reversal MISO and MIMO Arrays with IEEE 802.11g

    E-Print Network [OSTI]

    Stancil, Daniel D.

    Experimental Demonstration of Time-Reversal MISO and MIMO Arrays with IEEE 802.11g Devices through-- A practical demonstration of IEEE 802.11g trans- missions using time-reversal antenna arrays in MISO and MIMO with great potential for use in MISO (multiple-input single output) arrays [5, 6]. In this work we present

  20. Blind identification of MISO-FIR channels Carlos Est^ev~ao R. Fernandes

    E-Print Network [OSTI]

    Boyer, Edmond

    Blind identification of MISO-FIR channels Carlos Est^ev~ao R. Fernandes , Pierre Comon , G, vol.90 Abstract In this paper, we address the problem of determining the order of MISO channels to false alarm. Afterwards, we introduce the concept of MISO channel nested detectors based on a deflation

  1. An Opportunistic Virtual MISO (OVM) Protocol for Multi-hop Wireless Networks

    E-Print Network [OSTI]

    Perkins, Dmitri

    1 An Opportunistic Virtual MISO (OVM) Protocol for Multi-hop Wireless Networks Van Nguyen-utilized and performance is not maximized. In this work, we propose the Opportunistic Virtual MISO (OVM) protocol for multi-hop wireless networks. OVM combines virtual MISO (using space- time block codes) and cooperative diversity

  2. 1268 IEEE TRANSACTIONS ON COMMUNICATIONS, VOL. 59, NO. 5, MAY 2011 MISO Capacity with Per-Antenna Power Constraint

    E-Print Network [OSTI]

    Vu, Mai

    1268 IEEE TRANSACTIONS ON COMMUNICATIONS, VOL. 59, NO. 5, MAY 2011 MISO Capacity with Per scheme for a MISO channel with per-antenna power constraint. Two cases of channel state information--Per-antenna power, MISO capacity, MISO wire- less, beamforming. I. INTRODUCTION THE capacity of a MIMO wireless

  3. 50 IEEE COMMUNICATIONS LETTERS, VOL. 18, NO. 1, JANUARY 2014 On Ergodic Secrecy Rate for MISO Wiretap Broadcast Channels with

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    50 IEEE COMMUNICATIONS LETTERS, VOL. 18, NO. 1, JANUARY 2014 On Ergodic Secrecy Rate for MISO-input single-output (MISO) broadcast channel. We consider an extension of the model in [1], where a multiple MODEL AND ASSUMPTIONS We consider a MISO wiretap broadcast channel with M antennas at the BS, K mobile

  4. IEEE TRANSACTIONS ON SIGNAL PROCESSING, VOL. 62, NO. 4, FEBRUARY 15, 2014 993 Adaptive Limited Feedback for MISO Wiretap

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    Feedback for MISO Wiretap Channels With Cooperative Jamming Minyan Pei, A. Lee Swindlehurst, Fellow, IEEE--Cooperative jamming, feedback bits allocation, limited feedback, MISO wiretap channel. I. INTRODUCTION P HYSICAL layer for mul- tiple-input single-output (MISO) wiretap channels, which have Manuscript received May 30, 2013

  5. Stanford University Exploiting Channel Knowledge at the Tx in MISO and MIMO Wireless Exploiting Partial Channel Knowledge at

    E-Print Network [OSTI]

    Paulraj, Arogyaswami

    Stanford University Exploiting Channel Knowledge at the Tx in MISO and MIMO Wireless Exploiting Partial Channel Knowledge at the Transmitter in MISO and MIMO Wireless SPAWC 2003 Rome, Italy June 18 Exploiting Channel Knowledge at the Tx in MISO and MIMO Wireless Outline Introduction · Perfect CSI

  6. SMSE PRECODER DESIGN IN A MULTIUSER MISO SYSTEM WITH LIMITED FEEDBACK Muhammad Nazmul Islam and Raviraj Adve

    E-Print Network [OSTI]

    Adve, Raviraj

    SMSE PRECODER DESIGN IN A MULTIUSER MISO SYSTEM WITH LIMITED FEEDBACK Muhammad Nazmul Islam in the downlink of a multi-user (MU) multiple input single output (MISO) sys- tem with quantized channel state MISO linear transceivers that exist in the limited feedback literature. Second, we show analytically

  7. IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY, VOL. 56, NO. 3, MAY 2007 1197 An Interleave-Division-Multiplexing MISO System

    E-Print Network [OSTI]

    Ping, Li

    -Division-Multiplexing MISO System With Partial CSI at Transmitter Chuxiang Li, Kai Li, Xiaodong Wang, Senior Member, IEEE-division-multiplexing (IDM) multiple-input­ single-output (MISO) system with partial channel state information (CSI the performance of such an IDM-MISO system. In particular, an SNR tracking method is proposed to calculate

  8. BEAMFORMING AND PAPR REDUCTION FOR MISO-OFDM SYSTEMS Jingon Joung, Eui-Rim Jeong, and Yong H. Lee

    E-Print Network [OSTI]

    Lee, Yong Hoon

    BEAMFORMING AND PAPR REDUCTION FOR MISO-OFDM SYSTEMS Jingon Joung, Eui-Rim Jeong, and Yong H. Lee single-output (MISO) orthogonal frequency division multiplex- ing (OFDM) systems with beamforming, peak-to-average power ratio (PAPR), multiple- input single-output (MISO), beamforming. 1. INTRODUCTION

  9. DEGREES OF FREEDOM IN THE MISO BC WITH DELAYED-CSIT AND FINITE COHERENCE TIME: A SIMPLE OPTIMAL SCHEME

    E-Print Network [OSTI]

    Gesbert, David

    DEGREES OF FREEDOM IN THE MISO BC WITH DELAYED-CSIT AND FINITE COHERENCE TIME: A SIMPLE OPTIMAL the multi-input single-output (MISO) Broadcast Channel (BC), the multi-user (MU) downlink in a cell scheme was proposed in [9] for the time cor- related MISO broadcast channel with 2 users. This scheme

  10. A Low-Complexity Precoder for Large Multiuser MISO Systems Saif K. Mohammed, A. Chockalingam, and B. Sundar Rajan

    E-Print Network [OSTI]

    Kumar, Anurag

    A Low-Complexity Precoder for Large Multiuser MISO Systems Saif K. Mohammed, A. Chockalingam, and B--In this paper, we consider the problem of precoding in large multiuser MISO systems, where by `large' we mean i user has one receive antenna. Such large MISO systems will be of immense interest because of the high

  11. 170 IEEE TRANSACTIONS ON SIGNAL PROCESSING, VOL. 61, NO. 1, JANUARY 1, 2013 Competing for Secrecy in the MISO

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    in the MISO Interference Channel S. Ali A. Fakoorian, Member, IEEE, and A. Lee Swindlehurst, Fellow, IEEE Abstract--A secure communication game is considered for the two-user MISO Gaussian interference channel parameters on the NE strategies. Index Terms--Game theory, information theory, interference channel, MISO

  12. On the Degrees of Freedom of time correlated MISO broadcast channel with delayed CSIT

    E-Print Network [OSTI]

    Gesbert, David

    On the Degrees of Freedom of time correlated MISO broadcast channel with delayed CSIT Mari consider the time correlated MISO broadcast channel where the transmitter has partial knowledge estimation. However, many wireless applications must guarantee high-data rate and reliable commu- nication

  13. Beamforming in MISO Systems: Empirical Results and EVM-based Analysis

    E-Print Network [OSTI]

    Duarte, Melissa; Dick, Chris; Rao, Raghu

    2009-01-01T23:59:59.000Z

    We present an analytical, simulation, and experimental-based study of beamforming Multiple Input Single Output (MISO) systems. We analyze the performance of beamforming MISO systems taking into account implementation complexity and effects of imperfect channel estimate, delayed feedback, real Radio Frequency (RF) hardware, and imperfect timing synchronization. Our results show that efficient implementation of codebook-based beamforming MISO systems with good performance is feasible in the presence of channel and implementation-induced imperfections. As part of our study we develop a framework for Average Error Vector Magnitude Squared (AEVMS)-based analysis of beamforming MISO systems which facilitates comparison of analytical, simulation, and experimental results on the same scale. In addition, AEVMS allows fair comparison of experimental results obtained from different wireless testbeds. We derive novel expressions for the AEVMS of beamforming MISO systems and show how the AEVMS relates to important system ...

  14. Robust Precoder for Multiuser MISO Downlink with SINR Constraints

    E-Print Network [OSTI]

    Ubaidulla, P

    2008-01-01T23:59:59.000Z

    In this paper, we consider linear precoding with SINR constraints for the downlink of a multiuser MISO (multiple-input single-output) communication system in the presence of imperfect channel state information (CSI). The base station is equipped with multiple transmit antennas and each user terminal is equipped with a single receive antenna. We propose a robust design of linear precoder which transmits minimum power to provide the required SINR at the user terminals when the true channel state lies in a region of a given size around the channel state available at the transmitter. We show that this design problem can be formulated as a Second Order Cone Program (SOCP) which can be solved efficiently. We compare the performance of the proposed design with some of the robust designs reported in the literature. Simulation results show that the proposed robust design provides better performance with reduced complexity.

  15. On Ergodic Secrecy Capacity for Gaussian MISO Wiretap Channels

    E-Print Network [OSTI]

    Li, Jiangyuan

    2010-01-01T23:59:59.000Z

    A Gaussian multiple-input single-output (MISO) wiretap channel model is considered, where there exists a transmitter equipped with multiple antennas, a legitimate receiver and an eavesdropper each equipped with a single antenna. We study the problem of finding the optimal input covariance that achieves ergodic secrecy capacity subject to a power constraint where only statistical information about the eavesdropper channel is available at the transmitter. This is a non-convex optimization problem that is in general difficult to solve. Existing results address the case in which the eavesdropper or/and legitimate channels have independent and identically distributed Gaussian entries with zero-mean and unit-variance, i.e., the channels have trivial covariances. This paper addresses the general case where eavesdropper and legitimate channels have nontrivial covariances. A set of equations describing the optimal input covariance matrix are proposed along with an algorithm to obtain the solution. Based on this framew...

  16. MISO Capacity with Per-Antenna Power Constraint

    E-Print Network [OSTI]

    Vu, Mai

    2010-01-01T23:59:59.000Z

    We establish in closed-form the capacity and the optimal signaling scheme for a MISO channel with per-antenna power constraint. Two cases of channel state information are considered: constant channel known at both the transmitter and receiver, and Rayleigh fading channel known only at the receiver. For the first case, the optimal signaling scheme is beamforming with the phases of the beam weights matched to the phases of the channel coefficients, but the amplitudes independent of the channel coefficients and dependent only on the constrained powers. For the second case, the optimal scheme is to send independent signals from the antennas with the constrained powers. In both cases, the capacity with per-antenna power constraint is usually less than that with sum power constraint.

  17. 1696 IEEE TRANSACTIONS ON SIGNAL PROCESSING, VOL. 60, NO. 4, APRIL 2012 Robust Secure Transmission in MISO Channels

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    in MISO Channels Based on Worst-Case Optimization Jing Huang, Student Member, IEEE, and A. Lee-output (MISO) wiretap channels. Both the cases of direct transmission and cooperative jamming with a helper messages can be reliably transmitted to the receiver and kept perfectly secret from the eavesdropper

  18. Empirical Validation of Energy-Neutral Operation on Wearable Devices by MISO Beamforming of IEEE 802.11ac

    E-Print Network [OSTI]

    Shinozuka, Masanobu

    Empirical Validation of Energy-Neutral Operation on Wearable Devices by MISO Beamforming of IEEE.11ac's multiple input, single output (MISO) structure to focus the transmit power to im- prove environments, and they can act as a reliable source by emit- ting RF power in a controlled manner. Although RF

  19. Retail Demand Response in Southwest Power Pool

    E-Print Network [OSTI]

    Bharvirkar, Ranjit

    2009-01-01T23:59:59.000Z

    IOU IRC ISO LMP LBNL LSE MISO MP MRO MWG M&V NERC OATT PUCrecommended a focus on what MISO refers to as DRR Type IIis consistent with trends in MISO and elsewhere and suggests

  20. An In-situ materials analysis particle probe (MAPP) diagnostic to study particle density control and hydrogenic fuel retention in NSTX

    SciTech Connect (OSTI)

    Allain, Jean Paul [University of Illinois at Urbana-Champaign] (ORCID:000000031348262X)

    2014-09-05T23:59:59.000Z

    A new materials analysis particle probe (MAPP) was designed, constructed and tested to develop understanding of particle control and hydrogenic fuel retention in lithium-based plasma-facing surfaces in NSTX. The novel feature of MAPP is an in-situ tool to probe the divertor NSTX floor during LLD and lithium-coating shots with subsequent transport to a post-exposure in-vacuo surface analysis chamber to measure D retention. In addition, the implications of a lithiated graphite-dominated plasma-surface environment in NSTX on LLD performance, operation and ultimately hydrogenic pumping and particle control capability are investigated in this proposal. MAPP will be an invaluable tool for erosion/redeposition simulation code validation.

  1. Robust Downlink Beamforming in Multiuser MISO Cognitive Radio Networks

    E-Print Network [OSTI]

    Gharavol, Ebrahim A; Mouthaan, Koenraad

    2009-01-01T23:59:59.000Z

    This paper studies the problem of robust downlink beamforming design in a multiuser Multi-Input Single-Output (MISO) Cognitive Radio Network (CR-Net) in which multiple Primary Users (PUs) coexist with multiple Secondary Users (SUs). Unlike conventional designs in CR-Nets, in this paper it is assumed that the Channel State Information (CSI) for all relevant channels is imperfectly known, and the imperfectness of the CSI is modeled using an Euclidean ball-shaped uncertainty set. Our design objective is to minimize the transmit power of the SU-Transmitter (SU-Tx) while simultaneously targeting a lower bound on the received Signal-to-Interference-plus-Noise-Ratio (SINR) for the SU's, and imposing an upper limit on the Interference-Power (IP) at the PUs. The design parameters at the SU-Tx are the beamforming weights, i.e. the precoder matrix. The proposed methodology is based on a worst case design scenario through which the performance metrics of the design are immune to variations in the channels. We propose thr...

  2. A Robust Artificial Noise Aided Transmit Design for Miso Secrecy

    E-Print Network [OSTI]

    Li, Qiang

    2011-01-01T23:59:59.000Z

    This paper considers an artificial noise (AN) aided secrecy rate maximization (SRM) problem for a multi-input single-output (MISO) channel overheard by multiple single-antenna eavesdroppers. We assume that the transmitter has perfect knowledge about the channel to the desired user but imperfect knowledge about the channels to the eavesdroppers. Therefore, the resultant SRM problem is formulated in the way that we maximize the worst-case secrecy rate by jointly designing the signal covariance ${\\bf W}$ and the AN covariance ${\\bf \\Sigma}$. However, such a worst-case SRM problem turns out to be hard to optimize, since it is nonconvex in ${\\bf W}$ and ${\\bf \\Sigma}$ jointly. Moreover, it falls into the class of semi-infinite optimization problems. Through a careful reformulation, we show that the worst-case SRM problem can be handled by performing a one-dimensional line search in which a sequence of semidefinite programs (SDPs) are involved. Moreover, we also show that the optimal ${\\bf W}$ admits a rank-one str...

  3. Hard X-ray observations of Cygnus X-1 with the Miso telescope

    SciTech Connect (OSTI)

    Perotti, F.; Della Ventura, A.; Villa, G.

    1984-01-01T23:59:59.000Z

    The black hole candidate Cygnus X-1 was observed in the hard X-ray - soft gamma-ray energy range by the Miso telescope on two different occasions: in September 1979 and May 1980. Two hard X-ray states of the source have beem measured: in 1979 the observed spectrum confirms the superlow state measured in the same period by the HEAO-3 satellite, while in 1980 the Miso X-ray data are consistent with the so-called low state of Cygnus X-1. In both occasions, no gamma-ray excess has been observed above 200 keV. 9 references.

  4. May 1980 low energy gamma-ray observations with the MISO telescope

    SciTech Connect (OSTI)

    Perotti, F.; Della Ventura, A.; Villa, G.

    1983-01-01T23:59:59.000Z

    During a balloon flight of the MISO telescope on 1980 May 17, the Crab Nebula and the Seyfert galaxy NGC 4151 were studied over the photon energy range 0.03-16 MeV. The photon spectrum of the Crab Nebula was measured up to approximately 2 MeV. No gamma-ray emission from NGC 4151 was detected on this occasion.

  5. Effect in the KHT sarcoma of CCNU and MISO on cell cycle progression evaluated by flow-cytometry

    SciTech Connect (OSTI)

    Hill, S.A.; Bauer, K.D.; Keng, P.C.; Siemann, D.W.

    1984-09-01T23:59:59.000Z

    Previous studies using the KHT sarcoma have shown that misonidazole (MISO) enhances the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by as much as a factor of 2.0. In the present study flow cytometry was used to monitor the changing DNA distributions of cells dissociated from solid tumors at successive times following treatment with CCNU, applied either alone or in combination with 0.5 mg/g MISO. The proportion of cells in late S and the G/sub 2/M phases of the cell cycle increased gradually after CCNU treatment. MISO did not significantly change this block in cell progression, which persisted for at least 48 hr after treatment in all cases. CCNU shows marked carbamoylating activity, which has been associated with inhibition of RNA processing and with the degree of chemopotentiation achieved with MISO. By 24 hr after treatment, CCNU clearly altered the distribution of RNA, but no significant differences could be detected between results obtained from drug and drug plus sensitizer treated groups. These studies demonstrate the effect of CCNU on cell cycle progression in vivo. The addition of MISO did not result in further perturbation of the total tumor population, suggesting that cell cycle redistribution does not play a major role in chemopotentiation by MISO.

  6. Beamforming on the MISO interference channel with multi-user decoding capability

    E-Print Network [OSTI]

    Ho, Z K M; Jorswieck, E; Mochaourab, R

    2011-01-01T23:59:59.000Z

    This paper considers the multiple-input-single-output interference channel (MISO-IC) with interference decoding capability (IDC), so that the interference signal can be decoded and subtracted from the received signal. On the MISO-IC with single user decoding, transmit beamforming vectors are classically designed to reach a compromise between mitigating the generated interference (zero forcing of the interference) or maximizing the energy at the desired user. The particularly intriguing problem arising in the multi-antenna IC with IDC is that transmitters may now have the incentive to amplify the interference generated at the non-intended receivers, in the hope that Rxs have a better chance of decoding the interference and removing it. This notion completely changes the previous paradigm of balancing between maximizing the desired energy and reducing the generated interference, thus opening up a new dimension for the beamforming design strategy. Our contributions proceed by proving that the optimal rank of the...

  7. Outage Rate Regions for the MISO Interference Channel: Definitions and Interpretations

    E-Print Network [OSTI]

    Lindblom, Johannes; Larsson, Erik G

    2011-01-01T23:59:59.000Z

    We consider the slow-fading two-user multiple-input single-output (MISO) interference channel (IC), where the receivers treat the interference as additive Gaussian noise. We study the rate points that can be achieved, allowing a non-zero outage probability. The points which meet the outage probability specification constitute a so-called outage rate region. There exist several definitions of the outage rate regions for the IC, as for the broadcast and the multiple-access channels. We give four definitions for the outage region of the MISO IC. The definitions differ on whether the rates are declared in outage jointly or individually and whether there is instantaneous or statistical channel state information (CSI) at the transmitters. For the statistical CSI scenario, we discuss how to find the outage probabilities in closed form. We provide interpretations of the definitions and compare the corresponding regions via analytical and numerical results.

  8. Degrees of Freedom of Time Correlated MISO Broadcast Channel with Delayed CSIT

    E-Print Network [OSTI]

    Yang, Sheng; Gesbert, David; Yi, Xinping

    2012-01-01T23:59:59.000Z

    We consider the time correlated MISO broadcast channel where the transmitter has imperfect knowledge on the current channel state, in addition to delayed channel state information. By representing the quality of the current channel state information as P^-{\\alpha} for the signal-to-noise ratio P and some constant {\\alpha} \\geq 0, we characterize the optimal degree of freedom region for this more general two-user MISO broadcast correlated channel. The essential ingredients of the proposed scheme lie in the quantization and multicasting of the overheard interferences, while broadcasting new private messages. Our proposed scheme smoothly bridges between the scheme recently proposed by Maddah-Ali and Tse with no current state information and a simple zero-forcing beamforming with perfect current state information.

  9. Evolution of the Midwest ISO

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    -Transmission Owning Members Marketers · Allegheny Energy Supply · American Electric Power Co. · Automated Power Transmission System Operator, Inc. MAPP Fall Conference August 28, 2002 #12;Overview · General Background Information · MISO Today · MISO Evolution #12;General Background Information #12;General Utility Background

  10. Explicit Solution of Worst-Case Secrecy Rate for MISO Wiretap Channels with Spherical Uncertainty

    E-Print Network [OSTI]

    Li, Jiangyuan

    2011-01-01T23:59:59.000Z

    A multiple-input single-output (MISO) wiretap channel model is considered, that includes a multi-antenna transmitter, a single-antenna legitimate receiver and a single-antenna eavesdropper. For the scenario in which spherical uncertainty for both the legitimate and the eavesdropper channels is included, the problem of finding the optimal input covariance that maximizes the worst-case secrecy rate subject to a power constraint, is considered, and an explicit expression for the maximum worst-case secrecy rate is provided.

  11. Hard x-ray observations of Cygnus X-1 with the MISO telescope

    SciTech Connect (OSTI)

    Perotti, F.; Della Ventura, A.; Villa, G.; Bassani, L.; Butler, R.C.

    1986-01-01T23:59:59.000Z

    The results of hard x-ray, soft gamma-ray observations of the galactic black hole candidate, Cyg X-1, taken with the MISO telescope in October 1979 and May 1980 are presented, confirming the superlow state measured during September-October 1979 by the HEAO 3 satellite. The 1980 observation coincides with a low- to high-state transition and is consistent with HEAO 3 observations taken at the same epoch. No gamma-ray counting-rate excess above 200 keV was recorded in either observation. Apart from these two measurements, the observation of the Crab Nebula as an a posteriori calibration source is also described. 15 references.

  12. On the Degrees of Freedom of time correlated MISO broadcast channel with delayed CSIT

    E-Print Network [OSTI]

    Kobayashi, Mari; Gesbert, David; Yi, Xinping

    2012-01-01T23:59:59.000Z

    We consider the time correlated MISO broadcast channel where the transmitter has partial knowledge on the current channel state, in addition to delayed channel state information (CSI). Rather than exploiting only the current CSI, as the zero-forcing precoding, or only the delayed CSI, as the Maddah-Ali-Tse (MAT) scheme, we propose a seamless strategy that takes advantage of both. The achievable degrees of freedom of the proposed scheme is characterized in terms of the quality of the current channel knowledge.

  13. Coordination of Retail Demand Response with Midwest ISO Markets

    E-Print Network [OSTI]

    Bharvirkar, Ranjit

    2008-01-01T23:59:59.000Z

    MISO MP MRO MWDRI M&V NYISO PJM PUC RAP RFC RTO RTP SERC AirRTOs such as New England or PJM. In 2005 MISO became theEdison is a member of PJM). Interruptible (Total = 3398, N =

  14. Full Diversity Codes for MISO Systems Equipped with Linear or ML Detectors

    E-Print Network [OSTI]

    Liu, Jing; Wong, Kon Max

    2008-01-01T23:59:59.000Z

    In this paper, a general criterion for space time block codes (STBC) to achieve full-diversity with a linear receiver is proposed for a wireless communication system having multiple transmitter and single receiver antennas (MISO). Particularly, the STBC with Toeplitz structure satisfies this criterion and therefore, enables full-diversity. Further examination of this Toeplitz STBC reveals the following important properties: a) The symbol transmission rate can be made to approach unity. b) Applying the Toeplitz code to any signalling scheme having nonzero distance between the nearest constellation points results in a non-vanishing determinant. In addition, if QAM is used as the signalling scheme, then for independent MISO flat fading channels, the Toeplitz codes is proved to approach the optimal diversity-vs-multiplexing tradeoff with a ZF receiver when the number of channel uses is large. This is, so far, the first non-orthogonal STBC shown to achieve the optimal tradeoff for such a receiver. On the other han...

  15. Coordinated Beamforming for Multiuser MISO Interference Channel under Rate Outage Constraints

    E-Print Network [OSTI]

    Li, Wei-Chiang; Lin, Che; Chi, Chong-Yung

    2011-01-01T23:59:59.000Z

    This paper studies the coordinated beamforming design problem for the multiple-input single-output (MISO) interference channel, assuming only channel distribution information (CDI) at the transmitters. For a given requirement on the rate outage probability for receivers, we aim to maximize the system utility (e.g., the weighted sum rate, weighted proportional fairness rate, and the weighed harmonic mean rate) subject to the rate outage constraints and individual power constraints. The outage constraints, however, lead to a complicated, nonconvex structure for the considered beamforming design problem and make the optimization problem difficult to handle. While this nonconvex optimization problem can be solved in an exhaustive search manner, this brute-force approach is only feasible when the number of transmitter-receiver pairs is small. For a system with a large number of transmitter-receiver pairs, computationally efficient alternatives are necessary. The focus of this paper is hence on the design of such e...

  16. Robust Secure Transmission in MISO Channels Based on Worst-Case Optimization

    E-Print Network [OSTI]

    Huang, Jing

    2011-01-01T23:59:59.000Z

    This paper studies robust transmission schemes for multiple-input single-output (MISO) wiretap channels. Both the cases of direct transmission and cooperative jamming with a helper are investigated with imperfect channel state information (CSI) for the eavesdropper links. Robust transmit covariance matrices are obtained based on worst-case secrecy rate maximization, under both individual and global power constraints. For the case of an individual power constraint, we show that the non-convex maximin optimization problem can be transformed into a quasiconvex problem that can be efficiently solved with existing methods. For a global power constraint, the joint optimization of the transmit covariance matrices and power allocation between the source and the helper is studied via geometric programming. We also study the robust wiretap transmission problem for the case with a quality-of-service constraint at the legitimate receiver. Numerical results show the advantage of the proposed robust design. In particular, ...

  17. Source Optimization in MISO Relaying with Channel Mean Feedback: A Stochastic Ordering Approach

    E-Print Network [OSTI]

    Ding, Minhua

    2011-01-01T23:59:59.000Z

    This paper investigates the optimum source transmission strategy to maximize the capacity of a multiple-input single-output (MISO) amplify-and-forward relay channel, assuming source-relay channel mean feedback at the source. The challenge here is that relaying introduces a nonconvex structure in the objective function, thereby excluding the possible use of previous methods dealing with mean feedback that generally rely on the concavity of the objective function. A novel method is employed, which divides the feasible set into two subsets and establishes the optimum from one of them by comparison. As such, the optimization is transformed into the comparison of two nonnegative random variables in the Laplace transform order, which is one of the important stochastic orders. It turns out that the optimum transmission strategy is to transmit along the known channel mean and its orthogonal eigenchannels. The condition for rank-one precoding (beamforming) to achieve capacity is also determined. Our results subsume th...

  18. Outage Constrained Robust Transmit Optimization for Multiuser MISO Downlinks: Tractable Approximations by Conic Optimization

    E-Print Network [OSTI]

    Wang, Kun-Yu; Chang, Tsung-Hui; Ma, Wing-Kin; Chi, Chong-Yung

    2011-01-01T23:59:59.000Z

    In this paper we consider a probabilistic signal-to-interference and-noise ratio (SINR) constrained problem for transmit beamforming design in the presence of imperfect channel state information (CSI), under a multiuser multiple-input single-output (MISO) downlink scenario. In particular, we deal with outage-based quality-of-service constraints, where the probability of each user's SINR not satisfying a service requirement must not fall below a given outage probability specification. The study of solution approaches to the probabilistic SINR constrained problem is important because CSI errors are often present in practical systems and they may cause substantial SINR outages if not handled properly. However, a major technical challenge is how to process the probabilistic SINR constraints. To tackle this, we propose a novel relaxation- restriction (RAR) approach, which consists of two key ingredients-semidefinite relaxation (SDR), and analytic tools for conservatively approximating probabilistic constraints. Th...

  19. How to Fully Exploit the Degrees of Freedom in the Downlink of MISO Systems With Opportunistic Beamforming

    E-Print Network [OSTI]

    Xia, Minghua; Kim, Soo-Chang

    2008-01-01T23:59:59.000Z

    The opportunistic beamforming in the downlink of multiple-input single-output (MISO) systems forms $N$ transmit beams, usually, no more than the number of transmit antennas $N_t$. However, the degrees of freedom in this downlink is as large as $N_t^2$. That is, at most $N_t^2$ rather than only $N_t$ users can be simultaneously transmitted and thus the scheduling latency can be significantly reduced. In this paper, we focus on the opportunistic beamforming schemes with $N_tMISO systems over Rayleigh fading channels. We first show how to design the beamforming matrix with maximum number of transmit beams as well as least correlation between any pair of them as possible, through Fourier, Grassmannian, and mutually unbiased bases (MUB) based constructions in practice. Then, we analyze their system throughput by exploiting the asymptotic theory of extreme order statistics. Finally, our simulation results show the Grassmannian-based beamforming achieves the maximum ...

  20. Survival in subpopulations of cells derived from solid KHT sarcomas by centrifugal elutriation following treatment with CCNU and MISO

    SciTech Connect (OSTI)

    Hill, S.A.; Keng, P.C.; Siemann, D.W.

    1984-09-01T23:59:59.000Z

    Misonidazole (MISO) has been shown to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in a number of different animal tumor systems. The authors have investigated the response to therapy of the various subpopulations of cells comprising the KHT sarcoma, to determine whether chemopotentiation occurred as a preferential enhancement of killing in one subpopulation of cells. Twenty-four hr after drug treatment, cells dissociated from solid tumors were separated into homogeneous populations based on cell size by the technique of centrifugal elutriation. Clonogenic cell survival was measured for each elutriated fraction. In vivo treatment with MISO produced no measurable cell-kill across the cell cycle. Those cells in late G/sub 1/ and S phase 24 hr after treatment were most sensitive to CCNU alone. The enhancement of CCNU cytotoxicity by MISO occurred primarily in the early G/sub 1/ and S fractions. These data suggest that chemopotentiation does not occur equally in all tumor cell subpopulations and that some specificity of enhanced cell killing exists.

  1. Ber analysis of iterative turbo encoded miso wireless communication system under implementation of q-ostbc scheme

    E-Print Network [OSTI]

    Kabir, M Hasnat; Zaman, Mustari; Rashed, Md Golam

    2012-01-01T23:59:59.000Z

    In this paper, a comprehensive study has been made to evaluate the performance of a MISO wireless communication system. The 4-by-1 spatially multiplexed Turbo encoded system under investigation incorporates Quasi-orthogonal space-time block coding (Q-STBC) and ML signal detection schemes under QPSK, QAM, 16PSK and 16QAM digital modulations. The simulation results elucidate that a significant improvement of system performance is achieved in QAM modulation. The results are also indicative of noticeable system performance enhancement with increasing number of iterations in Turbo encoding/decoding scheme.

  2. System model Scope of Work Short term power constraint Long term power constraint Imperfect CSIR Prediction Summary Spatial and Temporal Power Allocation for MISO

    E-Print Network [OSTI]

    Bhashyam, Srikrishna

    System model Scope of Work Short term power constraint Long term power constraint Imperfect CSIR Prediction Summary Spatial and Temporal Power Allocation for MISO Systems with Delayed Feedback Srikrishna) feedback #12;System model Scope of Work Short term power constraint Long term power constraint Imperfect

  3. Optimal Use of Current and Outdated Channel State Information - Degrees of Freedom of the MISO BC with Mixed CSIT

    E-Print Network [OSTI]

    Gou, Tiangao

    2012-01-01T23:59:59.000Z

    We consider a multiple-input-single-output (MISO) broadcast channel with mixed channel state information at the transmitter (CSIT) that consists of imperfect current CSIT and perfect outdated CSIT. Recent work by Kobayashi et al. presented a scheme which exploits both imperfect current CSIT and perfect outdated CSIT and achieves higher degrees of freedom (DoF) than possible with only imperfect current CSIT or only outdated CSIT individually. In this work, we further improve the achievable DoF in this setting by incorporating additional private messages, and provide a tight information theoretic DoF outer bound, thereby identifying the DoF optimal use of mixed CSIT. The new result is stronger even in the original setting of only delayed CSIT, because it allows us to remove the restricting assumption of statistically equivalent fading for all users.

  4. A convex approximation approach to Weighted Sum Rate Maximization of Multiuser MISO Interference Channel under outage constraints

    E-Print Network [OSTI]

    Li, Wei-Chiang; Lin, Che; Chi, Chong-Yung

    2010-01-01T23:59:59.000Z

    This paper considers weighted sum rate maximization of multiuser multiple-input single-output interference channel (MISO-IFC) under outage constraints. The outage-constrained weighted sum rate maximization problem is a nonconvex optimization problem and is difficult to solve. While it is possible to optimally deal with this problem in an exhaustive search manner by finding all the Pareto-optimal rate tuples in the (discretized) outage-constrained achievable rate region, this approach, however, suffers from a prohibitive computational complexity and is feasible only when the number of transmitter-receive pairs is small. In this paper, we propose a convex optimization based approximation method for efficiently handling the outage-constrained weighted sum rate maximization problem. The proposed approximation method consists of solving a sequence of convex optimization problems, and thus can be efficiently implemented by interior-point methods. Simulation results show that the proposed method can yield near-optim...

  5. Single-User Beamforming in Large-Scale MISO Systems with Per-Antenna Constant-Envelope Constraints: The Doughnut Channel

    E-Print Network [OSTI]

    Mohammed, Saif Khan

    2011-01-01T23:59:59.000Z

    Large antenna arrays at the base station (BS) has recently been shown to achieve remarkable intra-cell interference suppression at low complexity. However, building large arrays in practice, would require the use of power-efficient RF amplifiers, which generally have poor linearity characteristics and hence would require the use of input signals with a very small peak-to-average power ratio (PAPR). In this paper, we consider the single-user Multiple-Input Single-Output (MISO) downlink channel for the case where the BS antennas are constrained to transmit signals having constant envelope (CE). We show that, with per-antenna CE transmission the effective channel seen by the receiver is a SISO AWGN channel with its input constrained to lie in a doughnut-shaped region. For single-path direct-line-of-sight (DLOS) and general i.i.d. fading channels, analysis of the effective doughnut channel shows that under a per-antenna CE input constraint, i) compared to an average-only total transmit power constrained MISO chan...

  6. MISO_Renewable_template

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment ofLetterEconomyDr. ErnestMID-CAREER RETIREMENT

  7. [MRO] Oligocrystalline Shape Memory Alloys

    E-Print Network [OSTI]

    Chen, Ying

    Copper-based shape memory alloys (SMAs) exhibit excellent shape memory properties in single crystalline form. However, when they are polycrystalline, their shape memory properties are severely compromised by brittle fracture ...

  8. Property:EIA/861/NercMro | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I Geothermal PwerPerkins County, Nebraska:PrecourtOid Jump to: navigation,AltFuelVehicle2 Jump

  9. Nachlass Ruth Alexander -Zeilberger: Mappe IV: Singspiel, verfasst von Ruth Alexander in Mnchen, 1936/37

    E-Print Network [OSTI]

    Zeilberger, Doron

    Kinderheim, als auch einzelne Betreuerin- nen gewürdigt. Tante Gerti zum Beispiel sorgt nicht nur für den

  10. Coordination of Retail Demand Response with Midwest ISO Markets

    E-Print Network [OSTI]

    Bharvirkar, Ranjit

    2008-01-01T23:59:59.000Z

    MISO, 2006) 2: MISO Reliability "Footprint" (Source: ICF,for power. Figure 2: MISO Reliability "Footprint" (Source:resources as part of the MISO reliability planning process.

  11. Beamforming and Rate Allocation in MISO Cognitive Radio Networks

    E-Print Network [OSTI]

    Tajer, Ali; Wang, Xiaodong

    2009-01-01T23:59:59.000Z

    We consider decentralized multi-antenna cognitive radio networks where secondary (cognitive) users are granted simultaneous spectrum access along with license-holding (primary) users. We treat the problem of distributed beamforming and rate allocation for the secondary users such that the minimum weighted secondary rate is maximized. Such an optimization is subject to (1) a limited weighted sum-power budget for the secondary users and (2) guaranteed protection for the primary users in the sense that the interference level imposed on each primary receiver does not exceed a specified level. Based on the decoding method deployed by the secondary receivers, we consider three scenarios for solving this problem. In the first scenario each secondary receiver decodes only its designated transmitter while suppressing the rest as Gaussian interferers (single-user decoding). In the second case each secondary receiver employs the maximum likelihood decoder (MLD) to jointly decode all secondary transmissions, and in the t...

  12. Robust Monotonic Optimization Framework for Multicell MISO Systems

    E-Print Network [OSTI]

    Björnson, Emil; Bengtsson, Mats; Ottersten, Björn

    2011-01-01T23:59:59.000Z

    The performance of multiuser systems is both difficult to measure fairly and to solve optimally. Most resource allocation problems are non-convex, even under simplifying assumptions such as perfect channel knowledge, homogeneous channel properties among users, and simple power constraints. Herein, we establish a general optimization framework that systematically solves these problems to global optimality. The proposed branch-reduce-and-bound (BRB) algorithm handles general multicell downlink systems with single-antenna users, multiantenna transmitters, arbitrary linear power constraints, and robustness to channel uncertainty. The problem of robust optimization with fairness-profile is solved at each iteration, which is a quasi-convex problem and a novel generalization of regular max-min fairness. The BRB algorithm is in general computationally costly, but it shows far better convergence than the previously known outer polyblock approximation algorithm. Our framework is suitable for computing benchmarks in gen...

  13. Linear Beamforming for the Spatially Correlated MISO broadcast channel

    E-Print Network [OSTI]

    Raghavan, Vasanthan; Hanly, Stephen

    2010-01-01T23:59:59.000Z

    A spatially correlated broadcast setting with M antennas at the base station and M users (each with a single antenna) is considered. We assume that the users have perfect channel information about their links and the base station has only statistical information about each user's link. The base station employs a linear beamforming strategy with one spatial eigen-mode allocated to each user. The goal of this work is to understand the structure of the beamforming vectors that maximize the ergodic sum-rate achieved by treating interference as noise. In the M = 2 case, we first fix the beamforming vectors and compute the ergodic sum-rate in closed-form as a function of the channel statistics. We then show that the optimal beamforming vectors are the dominant generalized eigenvectors of the covariance matrices of the two links. It is difficult to obtain intuition on the structure of the optimal beamforming vectors for M > 2 due to the complicated nature of the sum-rate expression. Nevertheless, in the case of asym...

  14. Property:EIA/861/IsoMiso | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to: navigation,PillarPublicationType JumpDOEInvolve JumpallowedAltFuelVehicle Jump

  15. EA-343 Midwest Independent Transmission Operator (MISO) | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197EFindingEA-257-CEA-296-B22

  16. EA-343 Midwest Independent Transmission Operator (MISO) | Department of

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015 Business42.1Energy |Final Site-WideBPAPowerEE US No.SubsidaryShellEnergy

  17. Blackout of 2003: Description and Responses

    E-Print Network [OSTI]

    Operator (MISO), National Electric Reliability Council, New York Times (including transcripts from the MISO

  18. PRESS HARD YOU ARE MAKING MULTIPLE COPIES B. MRO Name, Address, Phone No. and Fax No.

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy ChinaofSchaeferAprilOverviewEfficiencyofHSSPIA - I-ManageMisusePERMIT APPLICATION

  19. Feedback reduction techniques and fairness in multi-user MIMO broadcast channels with random beamforming

    E-Print Network [OSTI]

    Pugh, Matthew Owen

    2011-01-01T23:59:59.000Z

    of transmit beamforming for miso systems with imperfectand temporally correlated miso channels in the presence ofmultiple-input single-output (MISO) chan- nels. The effects

  20. Design and analysis of MIMO systems with practical channel state information assumptions

    E-Print Network [OSTI]

    Zheng, Jun

    2006-01-01T23:59:59.000Z

    Comparison with Optimal MISO CSI-Quantizers . . . . . . 9655 Capacity Analysis of MISO Systems with Finite-Rate CSIAnalysis of MISO CSI Quantizers with Mismatched Codebooks

  1. Large wireless networks : fundamental limits and design issues

    E-Print Network [OSTI]

    Minero, Paolo

    2010-01-01T23:59:59.000Z

    multiple-input single-output (MISO) channels between allnumber of independent MISO channels given by (2.8), rathercapacities of the individual MISO channels between the nodes

  2. Performance analysis of interference suppression techniques for multiple antenna systems

    E-Print Network [OSTI]

    Amihood, Patrick

    2007-01-01T23:59:59.000Z

    Pre-BLAST-DFE Technique for MISO Channels with DecentralizedPrecoding Operating over MISO Frequency Selec- tive Fadingon a Nonlinear Precoder for MISO Channels with Decentralized

  3. Feedback, power control, and beamforming : methods for situational aware wireless networks

    E-Print Network [OSTI]

    Huang, Yichao

    2012-01-01T23:59:59.000Z

    Outage balancing in multiuser MISO networks: network dualityOutage balancing in multiuser MISO networks: network dualitywith partial feedback for MISO downlink transmission using

  4. The Cost of Transmission for Wind Energy: A Review of Transmission Planning Studies

    E-Print Network [OSTI]

    Mills, Andrew D.

    2009-01-01T23:59:59.000Z

    2007. “Inclusion of Wind in the MISO Transmission Expansionhttp://www.jcspstudy.org/ Midwest ISO (MISO). 2007. Midwest+Planning Midwest ISO (MISO). 2003. Midwest Transmission

  5. Topological Interference Management through Index Coding

    E-Print Network [OSTI]

    Jafar, Syed A

    2013-01-01T23:59:59.000Z

    Degrees of freedom of the MISO BC with mixed CSIT,” IEEEof freedom of time correlated MISO broadcast channel withof alternating CSIT for the MISO BC,” IEEE Transactions on

  6. Widely linear equalization for MIMO and SISO communications systems using filter banks

    E-Print Network [OSTI]

    Pun, Ka Shun Carson

    2007-01-01T23:59:59.000Z

    Selective MISO Channel . . . . . . . . . . . . . . . .input-single- output (MISO) channel is not fully addressed.system in a frequency selective MISO channel and the WLE

  7. Exploiting Heterogeneous Channel Coherence Intervals for Blind Interference Alignment

    E-Print Network [OSTI]

    Jafar, Syed Ali

    2011-01-01T23:59:59.000Z

    On the degrees of freedom of MISO broadcast channels withtrend, are listed below. 1. MISO BC with no CSIT for onemultiple input single output (MISO) broadcast channel (BC)

  8. Mifepristone and Misoprostol Administered Simultaneously Versus 24 Hours Apart for Abortion

    E-Print Network [OSTI]

    Creinin, Mitchell David

    2007-01-01T23:59:59.000Z

    mifepristone in combination with miso- prostol administeredA randomized comparison of miso- prostol 6 to 8 hours versusmifepristone 200 mg and vaginal miso- prostol for abortion.

  9. A CRITICAL REVIEW OF WIND TRANSMISSION COST ESTIMATES FROM MAJOR TRANSMISSION PLANNING EFFORTS

    E-Print Network [OSTI]

    Mills, Andrew; Wiser, Ryan; Porter, Kevin

    2007-01-01T23:59:59.000Z

    Report.pdf Midwest ISO (MISO). 2003. Midwest TransmissionConference September 2007 MISO. 2007. Midwest Transmission2006 SDG&E Midwest ISO (MISO) ISO/RTO February 2007 MISO '06

  10. NAGOYA UNIVERSITY GLOBAL 30 INTERNATIONAL PROGRAMSPrinted in March 2014 Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan

    E-Print Network [OSTI]

    Takahashi, Ryo

    include miso-nikomi-udon (Nagoya-style udon noodles with miso soup) and miso-katsu (fried pork cutlets with rich red miso sauce). Nagoya cuisine is also well known for a variety of chicken dishes

  11. RNA Splicing Regulation in Drosophila melanogaster

    E-Print Network [OSTI]

    Brooks, Angela Norie

    2011-01-01T23:59:59.000Z

    Another method called MISO (Katz et al. 2010) performs thisand then quantified, while MISO requires an a priori set of

  12. The potential impacts of a competitive wholesale market in the midwest: A preliminary examination of centralized dispatch

    E-Print Network [OSTI]

    Lesieutre, Bernard C.; Bartholomew, Emily; Eto, Joseph H.; Hale, Douglas; Luong, Thanh

    2004-01-01T23:59:59.000Z

    states and three NERC reliability regions. MISO is the firstmulti-reliability-region operation. Membership in the MISO-

  13. A Review of Recent RTO Benefit-Cost Studies: Toward More Comprehensive Assessments of FERC Electricity Restructuring Policies

    E-Print Network [OSTI]

    Eto, Joseph H.; Lesieutre, Bernard C.

    2005-01-01T23:59:59.000Z

    initiated by the MISO reliability coordinator have rankedreliability coordinators. In addition, the severity of the TLRs called by MISO

  14. Degrees-of-Freedom Region of the MISO Broadcast Channel with General Mixed-CSIT

    E-Print Network [OSTI]

    Chen, Jinyuan

    2012-01-01T23:59:59.000Z

    In the setting of the two-user broadcast channel, recent work by Maddah-Ali and Tse has shown that knowledge of prior channel state information at the transmitter (CSIT) can be useful, even in the absence of any knowledge of current CSIT. Very recent work by Kobayashi et al., Yang et al., and Gou and Jafar, extended this to the case where, instead of no current CSIT knowledge, the transmitter has partial knowledge, and where under a symmetry assumption, the quality of this knowledge is identical for the different users' channels. Motivated by the fact that in multiuser settings, the quality of CSIT feedback may vary across different links, we here generalize the above results to the natural setting where the current CSIT quality varies for different users' channels. For this setting we derive the optimal degrees-of-freedom (DoF) region, and provide novel multi-phase broadcast schemes that achieve this optimal region. Finally this generalization incorporates and generalizes the corresponding result in Maleki e...

  15. Optimal and Robust Transmit Designs for MISO Channel Secrecy by Semidefinite Programming

    E-Print Network [OSTI]

    Li, Qiang

    2010-01-01T23:59:59.000Z

    In recent years there has been growing interest in study of multi-antenna transmit designs for providing secure communication over the physical layer. This paper considers the scenario of an intended multi-input single-output channel overheard by multiple multi-antenna eavesdroppers. Specifically, we address the transmit covariance optimization for secrecy-rate maximization (SRM) of that scenario. The challenge of this problem is that it is a nonconvex optimization problem. This paper shows that the SRM problem can actually be solved in a convex and tractable fashion, by recasting the SRM problem as a semidefinite program (SDP). The SRM problem we solve is under the premise of perfect channel state information (CSI). This paper also deals with the imperfect CSI case. We consider a worst-case robust SRM formulation under spherical CSI uncertainties, and we develop an optimal solution to it, again via SDP. Moreover, our analysis reveals that transmit beamforming is generally the optimal transmit strategy for SR...

  16. Non-Convex Utility Maximization in Gaussian MISO Broadcast and Interference Channels

    E-Print Network [OSTI]

    Rossi, M; Simeone, O; Haimovich, A M

    2011-01-01T23:59:59.000Z

    Utility (e.g., sum-rate) maximization for multiantenna broadcast and interference channels (with one antenna at the receivers) is known to be in general a non-convex problem, if one limits the scope to linear (beamforming) strategies at transmitter and receivers. In this paper, it is shown that, under some standard assumptions, most notably that the utility function is decreasing with the interference levels at the receivers, a global optimal solution can be found with reduced complexity via a suitably designed Branch-and-Bound method. Although infeasible for real-time implementation, this procedure enables a non-heuristic and systematic assessment of suboptimal techniques. A suboptimal strategy is then proposed that, when applied to sum-rate maximization, reduces to the well-known distributed pricing techniques. Finally, numerical results are provided that compare global optimal solutions with suboptimal (pricing) techniques for sum-rate maximization problems, leading to insight into issues such as the robus...

  17. The generation fleet in MISO is being affected by time, fuel...

    Office of Environmental Management (EM)

    Power Plan 111(b) & (d) Nature of Regulation Mercury and Air Toxics Standards Cross State Air Pollution Rule and Cooling Water Regulations (316(b)) New air quality standards Coal...

  18. Microsoft PowerPoint - MISO-SPP Market Impacts HydPwrConf 2014

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHighand RetrievalsFinalModule8.ppt MicrosoftDOE'sR.G. VanInChanging Energy

  19. EVLA Memo No. 39 Wayne Koski

    E-Print Network [OSTI]

    Groppi, Christopher

    -Inputs. The same is true for the Master-Input-Slave-Output (MISO) in that the Master-Input must connect to all the daisy chain method would best be avoided. MIB MOSI MISO SCLK SLAVE #1-A MOSI MISO SCLK SLAVE #1-B MOSI MISO SCLK SLAVE #1-C MOSI MISO SCLK SLAVE #2 MOSI MISO SCLK SLAVE #3 MOSI MISO SCLK SS* SS* SS* SS* SS

  20. EIS-0465: Pepco Holdings, Inc. Mid-Atlantic Power Path (MAPP) Project, Prince George's, Calvert, and Wicomico Counties, Maryland, and Sussex County, Delaware

    Broader source: Energy.gov [DOE]

    Pepco Holdings, Inc., cancelled its proposed Phase II of the Mid-Atlantic Power Pathway transmission line project and DOE cancelled preparation of an EIS on the potential environmental impacts of a proposed federal loan guarantee for the project.

  1. Maximizing the throughput of large ad hoc wireless networks

    E-Print Network [OSTI]

    Hua, Y; Huang, Y; Garcia-Luna-Aceves, J J

    2006-01-01T23:59:59.000Z

    multi-input, single-output (MISO) protocol. During eachthe maximum throughput of the MISO protocol, in bits-meters/s/ Hz/node, is C MISO = (n ? 1) A log 2 1 + 2n P T ? h

  2. The Necessity of Relay Selection

    E-Print Network [OSTI]

    Koyuncu, Erdem; Jafarkhani, Hamid

    2010-01-01T23:59:59.000Z

    multiple-input single-output (MISO) systems [16]–[19], itsfeedback beamforming in MISO systems, in which any set ofExample 3 (Comparison with MISO Systems). One of the most

  3. Transmit beamforming for multiple antenna systems with imperfect feedback

    E-Print Network [OSTI]

    Isukapalli, Yogananda R.

    2009-01-01T23:59:59.000Z

    a transmit beamforming MISO system with imperfect feedback.error proba- bility of a MISO transmit beamforming system,”of finite rate feedback MISO systems in the presence of es-

  4. Taking ramen seriously : food, labor, and everyday life in modern Japan

    E-Print Network [OSTI]

    Solt, George Sekine

    2009-01-01T23:59:59.000Z

    received small rations of miso, soy sauce, salt, cookingthat bread does not fit with miso soup, grilled fish, andpot, which I would eat with miso soup and salted cucumbers

  5. Factory Girl Literature: Sexuality, Violence, and Representation in Industrializing Korea

    E-Print Network [OSTI]

    Barraclough, Ruth

    2012-01-01T23:59:59.000Z

    suk shares a desk with Miso, who keeps a copy of a book byjealously what it is about, Miso responds that she has noMind your own business” Miso responds, who cannot explain

  6. 2011 Wind Technologies Market Report

    E-Print Network [OSTI]

    Bolinger, Mark

    2013-01-01T23:59:59.000Z

    WindLogics Inc. (2006) [MN-MISO (2006)]; EnerNex et al. (IPP ISO ISO-NE ITC kW kWh MISO MW MWh NERC NREL NYISO OEMIndependent System Operator (MISO), New York ISO (NYISO),

  7. 2009 Wind Technologies Market Report

    E-Print Network [OSTI]

    Wiser, Ryan

    2010-01-01T23:59:59.000Z

    Texas, May 24, 2010. MISO. 2010. Dispatchable Intermittentand Windlogics Inc. (2006) [MN-MISO]; Puget Sound Energy (ITC kW kWh LADWP LIBOR MISO American Wind Energy Association

  8. Spectrally efficient underwater acoustic communications : channel characterization and design aspects for OFDM

    E-Print Network [OSTI]

    Radoševi?, Andreja

    2012-01-01T23:59:59.000Z

    input single-output (MISO) and the MIMO setting with a rank-assess the ergodic capacity of MISO and MIMO UWA channels byfor two cases: an N t × 1 MISO system and a 2 × 2 MIMO

  9. Cooperative Multiplexing in Wireless Relay Networks

    E-Print Network [OSTI]

    Nagpal, Vinayak

    2012-01-01T23:59:59.000Z

    Input Multiple Output MISO Multiple Input Single Output MLno cooperation”) and 2×1 MISO (“unlimited cooperation”)Fig 2.6 achieves the 2 × 1 MISO bound for multiplexing gains

  10. Coordination of Retail Demand Response with Midwest ISO Markets

    E-Print Network [OSTI]

    Bharvirkar, Ranjit

    2008-01-01T23:59:59.000Z

    ER08-___-000," December 31. MISO, 2007b, M T E P 06 - TheMidwest ISO Transmission Expansion Plan, February. MISO,2007c, "MISO Press Release," U R L : http://

  11. Block-oriented nonlinear system identification using semidenite programming

    E-Print Network [OSTI]

    Han, Younghee

    2012-01-01T23:59:59.000Z

    identification method for MISO Wiener-Hammerstein model.multi-input single-output (MISO) case. More recent work canmulti-input single-output (MISO) case. More recent work can

  12. Correlation-based beamforming for multi-user MIMO channels

    E-Print Network [OSTI]

    Anderson, Adam L.

    2008-01-01T23:59:59.000Z

    W. Cheng and R. Murch, “MU-MISO transmission with limitedis found in [42] for the MISO channel or in [28] for theoutperforms DPC in the MISO broadcast channel. A similar

  13. Power Scheduling for Multi-Hop Wireless Networks

    E-Print Network [OSTI]

    Yu, Yuan

    2009-01-01T23:59:59.000Z

    an achievable sum rate for this MISO-BC relay net- work byBC relay network and MISO-BC relay network are investigatedreceiver. We will skip the MISO case since it is similar to

  14. Advanced Non-Krylov Subspace Model Order Reduction Techniques for Interconnect Circuits

    E-Print Network [OSTI]

    Yan, Boyuan

    2009-01-01T23:59:59.000Z

    decoupled into a number of MISO circuits based on the input-partitioned into many MISO systems and the traditionalcan be performed on these MISO systems. The new reduction

  15. Demand Response in U.S. Electricity Markets: Empirical Evidence

    E-Print Network [OSTI]

    Cappers, Peter

    2009-01-01T23:59:59.000Z

    Independent System Operator (MISO) and Southwest PowerTo help inform the debate at MISO and SPP concerning how tosettled using the EIS market. MISO administers a day-ahead

  16. Performance of Non-Gaussian Distribution Based Communication and Compressed Sensing Systems /

    E-Print Network [OSTI]

    Kwon, Hwan Joon

    2013-01-01T23:59:59.000Z

    by relating it to a MISO MAC communi- cation problem. Weof the |T |-sender Gaussian MISO MAC Y T = b X X w (j?1)b+iprobability distribution P. The MISO codeword index cho- sen

  17. Retrospective Interference Alignment

    E-Print Network [OSTI]

    Maleki, Hamed; Jafar, Syed A; Shamai, Shlomo

    2010-01-01T23:59:59.000Z

    On the degrees of freedom of miso broadcast channels withthe X channel [17, 16] and the MISO BC [5], the interferencea DoF perspective. While the 2 user MISO BC setting easily

  18. 2010 Wind Technologies Market Report

    E-Print Network [OSTI]

    Wiser, Ryan

    2012-01-01T23:59:59.000Z

    WindLogics Inc. (2006) [MN-MISO (2006)]; EnerNex et al. (IPP ISO ISO-NE ITC kW kWh MISO MW MWh NERC NREL NYISO OEMIndependent System Operator (MISO), New York ISO (NYISO),

  19. Performance analysis of multi-antenna OFDM systems with phase noise and imperfect channel estimation

    E-Print Network [OSTI]

    Jalloh, Mohamed

    2009-01-01T23:59:59.000Z

    136 6 Performance Analysis of MISO-OFDM with Phase Noise andMANet MBWA MC MIMO Mbps MMSE MISO MRC MS MSH Media Accessand also exist in SIMO and MISO channels. Multiplexing gain,

  20. Channel estimation and feedback for multiple antenna communication

    E-Print Network [OSTI]

    Murthy, Chandra Ramabhadra

    2006-01-01T23:59:59.000Z

    Schematic representation of a MISO system with beamformingcapacity of the correlated MISO channel with Q-EGT for di?Outage probability of the MISO channel with quantized EGT (t

  1. 2008 WIND TECHNOLOGIES MARKET REPORT

    E-Print Network [OSTI]

    Bolinger, Mark

    2010-01-01T23:59:59.000Z

    multi-year)* Xcel-PSCo MN-MISO** Puget Sound Energy Arizonaand Windlogics Inc. (2006) [MN-MISO]; Puget Sound Energy (2008 at 2006 Gas Prices MN-MISO Pacificorp-2004 Pacificorp-

  2. MHP: Master-Handoff Protocol for Fast and Energy-Efficient Data Transfer over SPI in Wireless Sensing Systems

    E-Print Network [OSTI]

    Yoo, Seung-mok

    2012-01-01T23:59:59.000Z

    and master in slave out (MISO). The master is responsibleto the master through the MISO line. The granularity of anCo-S has two serial the MISO pin should be set to output. On

  3. Degrees of Freedom of the Interference Channel with a Cognitive Helper

    E-Print Network [OSTI]

    Wang, Chenwei; Sezgin, Aydin

    2012-01-01T23:59:59.000Z

    For example, for the K-user SIMO/MISO Gaussian interferencewhich are identical to the MISO setting [1], i.e. , channelcan be seen as a special MISO interference channel where

  4. Interference suppression in spread-spectrum networks

    E-Print Network [OSTI]

    Sui, Haichang

    2007-01-01T23:59:59.000Z

    G. Proakis, “Analysis of a MISO pre- BLAST-DFE technique forpre-BLAST-DFE technique for MISO channels with decentralized

  5. SmartCast - Novel Textile Sensors for Embedded Pressure Sensing of Orthopedic Casts

    E-Print Network [OSTI]

    Danilovic, Andrew

    2013-01-01T23:59:59.000Z

    interface GROUND //pinMode(SPI_MISO_PIN, OUTPUT); //DO NOTTO //digitalWrite(SPI_MISO_PIN, LOW); pinMode(hardwareSS,

  6. 2010 Wind Technologies Market Report

    E-Print Network [OSTI]

    Wiser, Ryan

    2012-01-01T23:59:59.000Z

    kilowatt-hour Midwest Independent System Operator megawattPJM), Midwest Independent System Operator (MISO), New Yorkin 2009. The Midwest Independent System Operator (MISO) (net

  7. The potential impacts of a competitive wholesale market in the midwest: A preliminary examination of centralized dispatch

    E-Print Network [OSTI]

    Lesieutre, Bernard C.; Bartholomew, Emily; Eto, Joseph H.; Hale, Douglas; Luong, Thanh

    2004-01-01T23:59:59.000Z

    Company Midwest Independent System Operator Minnesota Power2005, the Midwest Independent System Operator (MISO) will2005, the Midwest Independent System Operator (MISO) will

  8. Coordination of Retail Demand Response with Midwest ISO Markets

    E-Print Network [OSTI]

    Bharvirkar, Ranjit

    2008-01-01T23:59:59.000Z

    Serving Entity Midwest Independent System Operator Marketin the Midwest Independent System Operator (MISO) region and2007). The Midwest Independent System Operator (MISO) called

  9. MISO Market Performance: An AgentMISO Market Performance: An Agent--Based Computational TestBased Computational Test--BedBed HongyanHongyan LiLiaa, andand LeighLeigh TesfatsionTesfatsionbb

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    managed via Locational Marginal Pricing (LMP) determined by ISO via bid/offer-based OPF. In April 2003 Companies (GenCos) & Load-Serving Entities (LSEs) located at various transmission buses Grid Congestion LMP Average LI (Lerner Index) With learning Fig.5 Average LMP and LI Levels as Demand-Bid Price

  10. On the Optimality of Beamforming for Multi-User MISO Interference Channels with Single-User Detection

    E-Print Network [OSTI]

    Shang, Xiaohu; Poor, H Vincent

    2009-01-01T23:59:59.000Z

    For a multi-user interference channel with multi-antenna transmitters and single-antenna receivers, by restricting each receiver to a single-user detector, computing the largest achievable rate region amounts to solving a family of non-convex optimization problems. Recognizing the intrinsic connection between the signal power at the intended receiver and the interference power at the unintended receiver, the original family of non-convex optimization problems is converted into a new family of convex optimization problems. It is shown that, for such interference channels with each receiver implementing single-user detection, transmitter beamforming can achieve all boundary points of the achievable rate region.

  11. Multi-User MISO Interference Channels with Single-User Detection: Optimality of Beamforming and the Achievable Rate Region

    E-Print Network [OSTI]

    Shang, Xiaohu; Poor, H Vincent

    2009-01-01T23:59:59.000Z

    For a multi-user interference channel with multi-antenna transmitters and single-antenna receivers, by restricting each transmitter to Gaussian input and each receiver to a single-user detector, computing the largest achievable rate region amounts to solving a family of non-convex optimization problems. Recognizing the intrinsic connection between the signal power at the intended receiver and the interference power at the unintended receiver, the original family of non-convex optimization problems is converted into a new family of convex optimization problems. It is shown that, for such interference channels with each receiver implementing single-user detection, transmitter beamforming can achieve all boundary points of the achievable rate region.

  12. NET DEGREES OF FREEDOM OF RECENT SCHEMES FOR THE MISO BC WITH DELAYED CSIT AND FINITE COHERENCE TIME

    E-Print Network [OSTI]

    Gesbert, David

    DoF that this scheme can be expected to yield in a realistic system by taking into account the cost Ericsson, Symantec, SAP, Monaco Telecom. Part of this work has been performed in the framework of the FP7 project ICT-317669 METIS, which is partly funded by the European Union. The authors would like

  13. NetDoFs of the MISO Broadcast Channel with Delayed CSIT Feedback for Finite Rate of

    E-Print Network [OSTI]

    Gesbert, David

    the main limiting factor in multi- user wireless communication systems. Tx side or Rx side zero-forcing (ZF by its industrial members: ORANGE, BMW Group, Swisscom, SFR, ST Microelectronics, Symantec, SAP, Monaco by the EU FP7 project METIS. delay is less than the channel coherence time. It was generally believed

  14. The generation fleet in MISO is being affected by time, fuel prices and multiple phases of environmental regulations

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23,EnergyChicopeeTechnology PerformanceDepartmentfor Improving Short September 8,

  15. doi:10.1006/jsco.2000.0374 Available online at http://www.idealibrary.com on

    E-Print Network [OSTI]

    Kallen, Wilberd

    j=1 b j+miso , b j+miso . diso i diso i = i j=1(b j , b j ) for i miso. ei element of standard matrix. miso the number of zero rows with which A starts presently. µij bi = b i + i-1 j=1 µi,jb j . n

  16. Multiagentov systmy Dr. Andrej Lcny

    E-Print Network [OSTI]

    Lucny, Andrej

    táto najlepsie pozdáva #12;Agent ­ klasifikácia poda voby (Chcem (Lúbi Miso ja )) Deliberatívny agent alebo KSA, ktoré volajú výpoctové procedúry Miso #12;Agent ­ klasifikácia poda voby Cisto reaktívny casu · deliberatívnymi postupmi upravujeme cinnos reaktívnych zloziek (Chcem (Lúbi Miso ja )) Miso #12

  17. A Review of Recent RTO Benefit-Cost Studies: Toward More Comprehensive Assessments of FERC Electricity Restructuring Policies

    E-Print Network [OSTI]

    Eto, Joseph H.; Lesieutre, Bernard C.

    2005-01-01T23:59:59.000Z

    Sponsored by Midwest Independent System Operator (MISO) CRA.price million Midwest Independent System Operator megawatt

  18. A Survey of Utility Experience with Real Time Pricing

    E-Print Network [OSTI]

    Barbose, Galen; Goldman, Charles; Neenan, Bernie

    2004-01-01T23:59:59.000Z

    probability Midwest Independent System Operator marginalopening of the Midwest Independent System Operator’s (MISO)

  19. 2008 WIND TECHNOLOGIES MARKET REPORT

    E-Print Network [OSTI]

    Bolinger, Mark

    2010-01-01T23:59:59.000Z

    Laboratory Midwest Independent System Operator NorthInterconnection, Midwest Independent System Operator (MISO),

  20. Real Time Pricing as a Default or Optional Service for C&I Customers: A Comparative Analysis of Eight Case Studies

    E-Print Network [OSTI]

    Barbose, Galen; Goldman, Charles; Bharvirkar, Ranjit; Hopper, Nicole; Ting, Michael; Neenan, Bernie

    2005-01-01T23:59:59.000Z

    Commission Midwest Independent System Operator megawattOPUC 2005). The Midwest Independent System Operator (MISO)

  1. [MRO] Search for resonant diboson production in the WW/WZ???jj decay channels with the ATLAS detector at ?s=7??TeV

    E-Print Network [OSTI]

    Taylor, Frank E.

    A search for resonant diboson production using a data sample corresponding to 4.7??fb[superscript -1] of integrated luminosity collected by the ATLAS experiment at the Large Hadron Collider in pp collisions at ?s=7??TeV ...

  2. K-NET busK-NET busK-NET busK-NET bus The K-Net bus is based on the SPI bus but it allows to addressing many different turrets

    E-Print Network [OSTI]

    Napp, Nils

    (standard SPI signal) Clock - MOSI (standard SPI signal) Master Out Slave In - MISO (standard SPI signal_COM MOSI MISO CLK PAI MASTER /F7 /CS_COM MOSI MISO CLK PAI SLAVE #0 /F7 /CS_COM MOSI MISO CLK PAI SLAVE #1 /F7 /CS_COM MOSI MISO CLK PAI SLAVE #2 All slave turrets are in IDLE state and are waiting

  3. Recent blackouts in US and continental Europe: is liberalisation to blame?

    E-Print Network [OSTI]

    Bialek, Janusz

    2004-06-16T23:59:59.000Z

    —but it did affect Midwest Independent System Operator (MISO) performance as reliability coordinator, even though PJM is the reliability coordinator for the DPL line. One of MISO’s primary system condition evaluation tools, its state estimator, was unable... an effective state estimator, MISO was unable to perform contingency analyses of generation and line losses within its reliability zone. Therefore, through 15:34 EDT MISO could not determine that with Eastlake 5 down, other transmission lines would overload...

  4. Computational Needs for the Next Generation Electric Grid Proceedings

    E-Print Network [OSTI]

    Birman, Kenneth

    2012-01-01T23:59:59.000Z

    Ott, “Unit commitment in PJM”, Technical Conference on Unit The long? term planning at PJM and MISO in terms of wind as two  exceptions.  In the Midwest, PJM and MISO, and in 

  5. 2012 Wind Technologies Market Report

    E-Print Network [OSTI]

    Wiser, Ryan

    2014-01-01T23:59:59.000Z

    MISO Transmission Expansion Plan 2012 megawatt megawatt-hour North American Electric ReliabilityMISO), New York ISO (NYISO), ISO-New England (ISO-NE), California ISO (CAISO), Electric Reliability

  6. Networks, deregulation, and risk : the politics of critical infrastructure protection

    E-Print Network [OSTI]

    Ellis, Ryan Nelson

    2011-01-01T23:59:59.000Z

    MISO) PJM Interconnection, key players in the outage, the Task Force found multiple violations of NERC’s voluntary reliability

  7. 2009 Wind Technologies Market Report

    E-Print Network [OSTI]

    Wiser, Ryan

    2010-01-01T23:59:59.000Z

    Offered Rate Midwest Independent System Operator MMS MNDOCInterconnection, Midwest Independent System Operator (MISO),2009. Midwest Independent Transmission System Operator, Inc.

  8. Energy Efficient Computing with the Low Power, Energy Aware Processing (LEAP) Architecture

    E-Print Network [OSTI]

    McIntire, Dustin Hale

    2012-01-01T23:59:59.000Z

    V17BUS -V17BUS SPI_CS_N SPI_MISO SEL_CLK SEL_LATCH CLKTIM-CS_N SPI_MOSI SPI_ CLK SPI_MISO RJ1 MHOLE4 RN9 SEL_LATCH 1RJ45_95622 MOLEX SPI_MISO 100K 5% CHIP_RES_ARRAY_EXB38V

  9. Inferior-Colliculus Responses to Amplitude-Modulated and Unmodulated Acoustic Tones and Cochlear-Implant Pulse Trains

    E-Print Network [OSTI]

    Schoenecker, Matthew Charles

    2010-01-01T23:59:59.000Z

    SCK_SEL); cbi(DDRB, PIN_MISO); //set MOSI as output //set CSselect to one //set MISO as input cbi(DDRD, PIN_INT1); //setCS 3 PIN_SCK 2 PIN_MOSI 0 PIN_MISO 1 PIN_SCK_SEL 4 sbi(port,

  10. Synchronization at low SNR in MIMO communications

    E-Print Network [OSTI]

    Amde, Manish

    2010-01-01T23:59:59.000Z

    for 1×1 SISO, 1×2 SIMO, 2×1 MISO and 2×2 MIMO pilot-based× 1 SIMO, 1 × 2 SIMO, 2 × 1 MISO and 2 × 2 MIMO systems. Wecode. The SIMO and MISO performances are identical, since

  11. 2010 Wind Technologies Market Report

    E-Print Network [OSTI]

    Wiser, Ryan

    2012-01-01T23:59:59.000Z

    and reliability assessments. Midwest Independent Transmission System Operator (MISO):MISO), New York ISO (NYISO), ISO-New England (ISO-NE), California ISO (CAISO), Electric Reliabilityreliability-based transmission issue and one economic transmission issue and provides economic benefits across multiple pricing zones within MISO (

  12. INTRODUCTION NIH NIDDK U01 DK082342-01

    E-Print Network [OSTI]

    Apkarian, A. Vania

    , MAPP Data Coordinating Core, University of Pennsylvania, Philadelphia, PA METHODS · Diffusion. · White matter mean diffusivity in a tract stretching between the corona radiata and superior longitudinal

  13. Misonidazole neurotoxicity in mice decreased by administration with pyridoxine

    SciTech Connect (OSTI)

    Eifel, P.J.; Brown, D.M.; Lee, W.W.; Brown, J.M.

    1983-10-01T23:59:59.000Z

    A series of toxicological and pharmacological experiments was performed to test the hypothesis that alterations of pyridoxine (Vitamin B/sub 6/) metabolism may play an important role in the development of misonidazole (MISO) neurotoxicity. The formation of a Schiff's base between the final reduction product of MISO, 2-amino MISO (NH/sub 2/-MISO), and pyridoxal-HCl in ethanol was demonstrated. Mice receiving daily intraperitoneal injections of MISO suffered significantly less toxicity (as determined by survival, weight gain and neurological tests) when large doses of pyridoxine-HCl (PYR) were delivered concomitantly, and consequently were able to tolerate administration of more than twice as many MISO injections. PYR did not alter the pharmacokinetics of MISO, either when given simultaneously or when given by multiple repeated daily injections prior to MISO. The administration of PYR also did not alter the radiosensitization by MISO in an in vivo-in vitro cloning assay with the EMT6 tumor in BALB/c mice. If depletion or altered metabolism of pyridoxine by reduced metabolites is also responsible for the neurotoxic effects of nitroimidazoles in humans, then concomitant administration of pyridoxine (in doses greater than the molar quantity of NH/sub 2/-MISO formed) should inhibit the development of such symptoms and allow administration of larger doses of MISO than are currently clinically employable.

  14. Microsoft PowerPoint - Till.ppt

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Kentucky Utilities (E.ON)* TVA Big Rivers Electric Coop Ameren* AECI Batesville Balancing Authority NPCC MRO RFC SPP SERC FRCC Central TVA & CPPP - Central to the Eastern...

  15. Life-Cycle Water Impacts of U.S. Transportation Fuels

    E-Print Network [OSTI]

    Scown, Corinne Donahue

    2010-01-01T23:59:59.000Z

    and Sustainability: U.S. Electricity Consumption for Watervaries widely. Electricity consumption in the MRO and HICCNERC region, so all electricity consumption is assigned the

  16. China’s Military Representatives: Striving Toward Professional Contracting and Procurement

    E-Print Network [OSTI]

    Puska, Susan M; McReynolds, Joe; Geary, Debra

    2011-01-01T23:59:59.000Z

    di- rection. Military representative reform could raise2011 China’s Military Representatives: Striving Towardreforms is the Military Representative Office (MRO) system

  17. Receptor binding characteristics of tritiated misoprostol free acid in enriched canine parietal cells

    SciTech Connect (OSTI)

    Tsai, B.S.; Kessler, L.K.; Conway, R.G.; Schoenhard, G.; Stolzenbach, J.; Collins, P.; Kramer, S.; Butchko, G.M.; Bauer, R.F.

    1986-03-01T23:59:59.000Z

    Misoprostol (MISO) is a synthetic prostaglandin (PG) E/sub 1/ methyl ester with gastric antisecretory and mucosal protective properties. MISO is rapidly de-esterified to misoprostol free acid (MISO-FA) in enriched (65-80%) canine parietal cell preparations. Both forms appear to possess equivalent antisecretory potency and (/sup 3/H) MISO-FA is stable in these preparations. (/sup 3/H) MISO-FA binding was reversible and saturable with a maximal number of binding sites estimated at 8138 +/- 1893 per cell. The scatchard plot was linear, indicating a single, high affinity receptor population with a dissociation constant of 11 +/- 2.6 x 10/sup -9/ M. Unlabeled MISO-FA and MISO were equally potent inhibitors (IC/sub 50/, approx. 10/sup -8/M) of (/sup 3/H) MISO-FA binding. At 10/sup -5/ M, the dinor and tetranor ..beta..-oxidation metabolites of MISO were weak binding inhibitors. Strict stereospecific binding was shown by MISO stereoisomers, and the 11R, 16S isomer was most active. Both PGE/sub 1/ and 16,16 dimethyl PGE/sub 2/ were potent binding inhibitors, but PGF/sub 1/..cap alpha.. (10/sup -6/ M) and Hoe 892 (10/sup -5/ M), a stable PGI/sub 2/ analog, were weak inhibitors. Neither histamine or cimetidine competed for binding sites. These data indicate the presence of stereospecific E-type prostaglandin receptors in enriched canine parietal cell preparations.

  18. High dose misonidazole with dexamethasone rescue: a possible approach to circumvent neurotoxicity

    SciTech Connect (OSTI)

    Urtasun, R.C.; Tanasichuk, H.; Fulton, D.; Agboola, O.; Turner, A.R.; Koziol, D.; Raleigh, J.

    1982-03-01T23:59:59.000Z

    With a view of modifying misonidazole (MISO) neurotoxicity, we initiated a randomized clinical study to assess a possible drug interaction and toxicity protection when dexamethasone (DXM) is administered concomitantly with MISO. The ongoing study consists of: 1. Pharamacokinetic evaluation; 2. Assessment of toxicity. Fourteen patients undergoing radiation therapy for different types of malignant neoplasia (excluding brain tumors) have been randomized to receive either MISO alone, or DXM one week prior and during treatment with MISO. Five of seven patients receiving MISO alone developed peripheral neuropathies while only one out of 7 patients that received MISO with DXM coverage developed a transient and mild neuropathy. Pharmacokinetic evaluation of MISO in plasma and urine of those patients receiving DXM has shown no evidence of drug interaction. It is postulated that the mechanism of action of DXM is at the nerve cell membrane level, restoring and stabilizing cell surface properties. In future studies we will investigate the use of DXM with increasing doses of MISO above the recommended maximum dose of 12 gm/m/sup 2/, hoping to achieve a higher tumor tissue level of MISO while avoiding unacceptable toxicity. The effect of Allopurinol on the plasma kinetics of MISO was studied in four additional patients, observing also no evidence of drug interaction.

  19. Metabolism and excretion of (/sup 3/H)misonidazole by hypoxic rate liver

    SciTech Connect (OSTI)

    Smith, B.R.; Born, J.L.

    1984-08-01T23:59:59.000Z

    This investigation was initiated to determine if misonidazole's biological activity is related to hypoxia-dependent, reductive biotransformation to form reactive metabolites. This study was facilitated by the synthesis of (/sup 3/H)misonidazole and by use of the isolated perfused rat liver as a model system for hypoxic tissue. Reductive metabolism of MISO by perfused livers was enhanced by hypoxic conditions. Formation of a MISO-derived glutathione conjugate (MISO-GSH) and covalent binding of MISO-derived radioactivity to tissue protein was also enhanced by hypoxia. Depletion of hepatic GSH with diethyl maleate increased the extent of covalent binding to protein under both aerobic and hypoxic conditions, and greatly diminished the formation of MISO-GSH. These results support the hypothesis that hypoxic conditions facilitate reductive metabolism of MISO to an alkylating agent, and that GSH plays an intervening role in the alkylation reaction.

  20. Stable reduction product of misonidazole

    SciTech Connect (OSTI)

    Panicucci, R.; McClelland, R.A.; Rauth, A.M.

    1986-07-01T23:59:59.000Z

    The predominant stable product (greater than 80%) of the anaerobic radiation chemical reduction (pH 7, formate, N/sub 2/O) of misonidazole (MISO) has been identified as the cyclic guanidinium ion MISO-DDI, a 4,5-dihydro-4,5-dihydroxyimidazolium ion. This cation was prepared as its sulfate salt by the reaction of glyoxal and the appropriate N-substituted guanidinium sulfate. Its formation during MISO reduction was established by NMR spectral comparison and by derivatization as glyoxal bis-oxime, which was formed in 86% yield in fully reduced systems. The toxicity of pure MISO-DDI X sulfate was examined in vivo (C/sub 3/H mice) and in vitro (CHO cells). This product is less toxic than the parent MISO and free glyoxal. A reactive, short-lived, intermediate is suggested as the agent responsible for the toxicity of MISO under hypoxic conditions.

  1. Azomycin riboside: a new radiosensitizer

    SciTech Connect (OSTI)

    Pedersen, J.E.; Barron, G.; Chapman, J.D.

    1982-03-01T23:59:59.000Z

    Azomycin riboside (2-nitro-1-..beta..-D-ribofuranosylimidazole) (AR), a nucleoside analogue with the base component replaced by a 2-nitroimidazole was studied to determine its potential as a radiosensitizer. In vitro evidence showed that AR is as good as or slightly better than misonidazole (MISO) as a hypoxic cell radiosensitizer. AR was also found to kill hypoxic cells directly and this cytotoxicity was at least as great as MISO cytotoxicity. However, when tumor regrowth delay was used to assess in vivo radiosensitization, AR was found to be inferior to MISO while the LD50 host toxicity assay indicated that AR might be nearly as toxic as MISO. Unless AR proves to be less toxic than MISO or can be selectively distributed with nucleoside transport inhibitors, these preliminary observations have not shown any advantage of AR over MISO as a potential clinically useful radiosensitizer.

  2. Inhibition of X-ray-induced potentially lethal damage (PLD) repair in aerobic plateau-phase Chinese hamster cells by misonidazole

    SciTech Connect (OSTI)

    Brown, D.M.

    1984-01-01T23:59:59.000Z

    The effect of the 2-nitroimidazole radiosensitizer misonidazole (MISO) and the hydrophilic analog SR-2508 on the repair of X-ray-induced potentially lethal damage (PLD) was studied in plateau-phase Chinese Hamster ovary (HA-1) cells. It was found that although MISO does not radiosensitize aerobic cells, it inhibits the repair of PLD. However, under hypoxic conditions, MISO has no effect on PLD repair. The major portion of the inhibition of PLD repair in aerobic cells requires the presence of MISO only during irradiation; little or no additional inhibition occurs when MISO is present during the postirradiation repair period. Also, treatment of aerobic cells with 5 mM MISO for either 5 or 30 min prior to irradiation is equally inhibitory. This suggests that the presence of MISO in some way modifies the initial lesion under aerobic conditions since it does not increase cell killing as determined by immediate plating but inhibits subsequent repair. The inhibition is concentration dependent; 0.5 mM MISO inhibits PLD repair by one-half while 5-10 mM totally inhibits the repair measured 6 hr postirradiation. This phenomenon suggests that radiosensitization of tissue in vivo by MISO and other 2-nitroimidazoles may not be unequivocal proof of the presence of hypoxic cells.

  3. NAESB Business Practice Subcommittee (BPS) ATC Project

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    thus far * 10114 NAESB BPS ATC Project Kick Off * 107 - 10814 NAESB BPS Meeting (MISO - Carmel, IN) * 1028 - 102914 NAESB BPS Meeting (PJM - Valley Forge, PA) Future...

  4. Data:9cbd1d7d-e255-47ce-8bbb-b832b38331af | Open Energy Information

    Open Energy Info (EERE)

    Indiana Gas & Elec Co Effective date: 20110503 End date if known: Rate name: DR - Miso Demand Response Rider Sector: Description: AVAILABILITY This Rider shall be available...

  5. Coordination of Retail Demand Response with Midwest ISO Markets

    E-Print Network [OSTI]

    Bharvirkar, Ranjit

    2008-01-01T23:59:59.000Z

    Robinson, Michael, 2008, "Demand Response in Midwest ISOPresentation at MISO Demand Response Working Group Meeting,Coordination of Retail Demand Response with Midwest ISO

  6. 2008 WIND TECHNOLOGIES MARKET REPORT

    E-Print Network [OSTI]

    Bolinger, Mark

    2010-01-01T23:59:59.000Z

    Demonstration Program. Puget Sound Energy. 2007. 2007Bellevue, Washington: Puget Sound Energy. Shiu, H. , M.year)* Xcel-PSCo MN-MISO** Puget Sound Energy Arizona Pub.

  7. 2009 Wind Technologies Market Report

    E-Print Network [OSTI]

    Wiser, Ryan

    2010-01-01T23:59:59.000Z

    Portland General Electric. Puget Sound Energy. 2007. 2007Bellevue, Washington: Puget Sound Energy. SCE. 2010.Inc. (2006) [MN-MISO]; Puget Sound Energy (2007) [Puget

  8. Energy Factors, Leasing Structure and the Market Price of Office Buildings in the U.S.

    E-Print Network [OSTI]

    Jaffee, Dwight; Stanton, Richard; Wallace, Nancy

    2012-01-01T23:59:59.000Z

    York (several hubs), Ontario, PJM, MISO, ERCOT South, Intocontract delivering into the PJM Western hub. Assuming thatpeak real-time prices posted by PJM Interconnection, LLC, on

  9. Energy Factors, Leasing Structure and the Market Price of Office Buildings in the U.S.

    E-Print Network [OSTI]

    Jaffee, Dwight M.; Stanton, Richard; Wallace, Nancy E.

    2010-01-01T23:59:59.000Z

    York (several hubs), Ontario, PJM, MISO, ERCOT South, Intocontract delivering into the PJM Western hub. Assuming thatpeak real-time prices posted by PJM Interconnection, LLC, on

  10. NAESB Business Practice Subcommittee (BPS) ATC Project

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    By Phone * 10114 NAESB BPS ATC Project Kick Off * 107 - 10814 NAESB BPS - MISO (Carmel, IN) * 112515 - NAESB BPS Conference Call * 12215 - NAESB BPS Conference...

  11. Control of a benchmark structure using GA-optimized fuzzy logic control 

    E-Print Network [OSTI]

    Shook, David Adam

    2009-05-15T23:59:59.000Z

    . 15. FLC Sketch of MIMO Case............................................................................... 26 Fig. 16. Rendering of MISO (a) and MIMO (b) Structures............................................ 27 Fig. 17. (a) Initial Random... Floor: El Centro 100 gal...................... 77 Fig. 60. FFT of Acceleration Responses for 3 rd Floor: Sinusoidal Excitation................ 77 Fig. 61. Pareto Fronts Resulting from MISO GA Optimization..................................... 79...

  12. IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS, VOL. 25, NO. 2, FEBRUARY 2007 1 On Broadcasting with Cooperative Diversity in

    E-Print Network [OSTI]

    Krishnamurthy, Srikanth

    to as a Virtual MISO (multiple-input single-output) link. In contrast, if an omni-directional transmitter-output) link. The terms cooperative diversity, virtual antenna arrays or virtual MISO links are used interchangeably in this paper. achieved transmission range, (ii) the achievable data rate, or (iii) reliability

  13. A Novel Preamble Design for OFDM Transmission Parameter Signalling

    E-Print Network [OSTI]

    Chen, Sheng

    - input single-output (SISO) and multiple-input single-output (MISO) transmission modes are supported. Quick and reliable detection of the transmission parameters is critical for the receiver to perform), including the FFT size and SISO/MISO mode [5]. In the time domain, a novel cyclic extension structure

  14. ON THE IMPACT OF MULTI-ANTENNA RF TRANSCEIVERS' AMPLITUDE AND PHASE MISMATCHES ON TRANSMIT MRC

    E-Print Network [OSTI]

    Langendoen, Koen

    both spatial diversity and array gain in downlink Multiple-Input Single-Output (MISO) links a faster and more reliable charac- terization as well as provides insight into the relative importance-Output (MISO) downlink scenarios, where the multiple-antenna basestation would optimally weigh the trans- mit

  15. Diversity Routing for Multi-hop Wireless Networks with Cooperative Transmissions

    E-Print Network [OSTI]

    Sivakumar, Raghupathy

    in multi-hop wireless networks to achieve virtual MISO (multiple input single output) links. Specifically reliability or error rate performance at the receiver is improved since the probability of all of them being (MISO), or a Single Input Multiple Output (SIMO), or a Multiple Input Multiple Output (MIMO) system

  16. Reduced Rank Space-Time Equalization Erik Lindskog Claes Tidestav

    E-Print Network [OSTI]

    of the advance operator . Multiple-input-single-output (MISO) filters will be represented as polynomial row. Further, the complex conjugate transpose of a filter (MISO or SIMO) is defined as ¦R¦S ˇ¤Ł TVURWTX of the noise cannot be reliably esti- mated [3], we will consider the noise to

  17. Power Efficient Broadcasting with Cooperative Diversity in Ad hoc Networks

    E-Print Network [OSTI]

    Krishnamurthy, Srikanth

    - munications can help combat interference and fading and hence, significantly improve the reliability-Output (MISO) system, a Single-Input Multi-Output (SIMO) system or a Multi-Input Multi- Output (MIMO) system exploits the broadcast nature of the wireless channel to emulate a MISO system. Nodes par- ticipating

  18. Synchronization in Cooperative Networks: Estimation of Multiple Carrier Frequency Offsets

    E-Print Network [OSTI]

    Blostein, Steven D.

    and reliability when assuming perfect synchronization [2]. Moreover, even though many coop- erative space coding synchronization is key to future deployments of cooperative networks. Multiple-input-single-output (MISO) systems methods for MISO systems include [5]­[7]. In [5], a maximum-likelihood estimator (MLE) for CFO estimation

  19. Tranceiver Design using Linear Precoding in a Multiuser MIMO System with Limited

    E-Print Network [OSTI]

    Adve, Raviraj

    (MU) multiple input single output (MISO) and multiple input multiple output (MIMO) Page 1 of 23 IET increase system reliability as well as the spectral efficiency of multiuser systems. However, limitations caused by interference and channel fading remain a concern in MU MISO and MU MIMO systems. These can

  20. Effect of nitroimidazoles on the oxygen consumption rate and respiratory control ratio of beef heart mitochondria

    SciTech Connect (OSTI)

    Chao, C.F.; Ting, L.; Subjeck, J.R.; Johnson, R.J.

    1984-08-01T23:59:59.000Z

    The neurotoxic effect of the nitroimidazole radiosensitizers misonidazole (MISO) and desmethylmisonidazole (DMM) has seriously compromised their clinical effectiveness. The authors compare here the effect of MISO and DMM on oxygen consumption in purified beef heart mitochondria. MISO has been found to significantly increase the oxygen consumption rate and decrease the respiratory control ratio in isolated mitochondria when incubated in the presence of the NAD+ dependent substrate, ..beta..-hydroxybutyrate. DMM has a similar but less pronounced effect than MISO on these respiratory parameters. When mitochondria were incubated in the presence of these radiosensitizers for 8, 15, 30, 45, and 60 minutes, the oxygen consumption rate was decreased when succinate, a FAD dependent substrate, was added following the incubation. This decrease, which is both time and dosage dependent, is equivalent for MISO and DMM.

  1. CHRONICLE 46, No.5, December 2011 He Kupu Whakamahara

    E-Print Network [OSTI]

    Hickman, Mark

    recognition for his work. Dr Mark Quigley (Geological Sciences) has been presented with the New Zealand of Science and Innovation, Dr Wayne Mapp, at a ceremony held in Wellington recently. Dr Quigley, a senior

  2. Regional measurements of /sup 14/Cmisonidazole distribution and blood flow in subcutaneous RT-9 experimental tumors

    SciTech Connect (OSTI)

    Blasberg, R.; Horowitz, M.; Strong, J.; Molnar, P.; Patlak, C.; Owens, E.; Fenstermacher, J.

    1985-04-01T23:59:59.000Z

    Regional (/sup 14/C)misonidazole-derived radioactivity (MISO*) was measured by quantitative autoradiography in s.c. RT-9 experimental tumors 0.5, 2, and 4 h after an i.v. bolus (25 mg) and constant infusion (10 mg/h) in rats. Misonidazole (MISO) concentration in plasma, tumor, and other tissues was also measured by high-pressure liquid chromatography. The distribution of MISO* in the tumors always resulted in a characteristic pattern with high peripheral and low central values. The high-activity regions in the tumor rim achieved tissue: plasma MISO* activity ratios of 0.97 and 2.2 by 0.5 and 4 h, respectively; for central tumor regions, this ratio was 0.20 and 0.32 for the same periods, respectively. The limited distribution of MISO* to central tumor regions could be correlated to low values of blood flow (measured with (/sup 131/I)iodoantipyrine) and to diffusion from peripheral tumor regions. Low blood flow in the central regions of these tumors will significantly limit the distribution of MISO and other drugs to viable-appearing cells in these areas and could account in part for the failures of chemotherapy in certain solid tumors. Pharmacokinetic modeling indicates that 1 to 9 h may be necessary for MISO concentrations in some tumor regions to reach 50% of that in plasma.

  3. Response of an experimental mammary carcinoma to fractionated x-irradiation with misonidazole and microwave hyperthermia

    SciTech Connect (OSTI)

    Goldfeder, A.; Brown, D.M.

    1984-08-01T23:59:59.000Z

    X/Gf mice bearing the MT2 mammary adenocarcinoma were subjected to 4000 rad of x rays given either as a single dose, or five daily fractions of 800 rad. Additional experimental groups were treated with either short term localized microwave hyperthermia (LMH), or the hypoxic cell radiosensitizer misonidazole (MISO), or both hyperthermia plus MISO with x rays. The combined use of MISO plus 42.5/sup 0/C with x rays was superior to the other treatment regimens as assessed by tumor regrowth delay and mean survival time. However, for the five fraction schedule, the addition of MISO plus hyperthermia was not as effective as observed for the single dose treatment. This may be attributed to reoxygenation of the hypoxic tumor cells between treatment fractions. MISO retention in tumor tissue under ambient and hyperthermic conditions was studied. The application of heat locally to the tumors caused a significant increase in MISO tumor concentration. However, after four x ray fractions the influence on MISO concentration by hyperthermia in the tumors could not be demonstrated.

  4. Tissue distribution of sup 14 C- and sup 3 H-labelled misonidazole in the tumor-bearing mouse

    SciTech Connect (OSTI)

    Cobb, L.M.; Nolan, J.; Butler, S. (MRC Radiobiology Unit, Didcot, Oxon (England))

    1990-02-01T23:59:59.000Z

    The retention of labelled misonidazole (MISO) was measured in a range of normal tissues in the mouse 24 hr after the intravenous injection of ({sup 14}C)MISO (ring labelled) and ({sup 3}H)-MISO (side-arm labelled). For ({sup 14}C)MISO the 24 hr tissue retention, in order of the highest to the lowest levels (excluding pathways of excretion), was esophageal epithelium, liver, foot pad, eyelid, lung, subcutaneous lung tumor (A110), esophageal wall, uterus, eye ball, blood, salivary gland, spleen, voluntary muscle, pancreas, inguinal fat. It was assumed that the {sup 14}C represented MISO metabolite(s) bound to macromolecules. An approximately similar pattern was observed for ({sup 3}H)MISO, but a higher percentage of the injected activity per gram of tissue was retained, probably due to the presence of tritiated water in the tissues. It has generally been assumed that significant levels of MISO binding are restricted to hypoxic tissues, for example tumors, but the present results show that significant levels of binding can also occur in apparently normoxic tissues. The explanation is put forward that this binding may be due to local high levels of nitroreductase capacity.

  5. Effect of prolonged high dose misonidazole on tumor response to radiation

    SciTech Connect (OSTI)

    McNally, N.J.; de Ronde, J.; Hinchliffe, M.

    1984-08-01T23:59:59.000Z

    WHFIB and SA F tumors were exposed to misonidazole (MISO) concentrations of 2.5 mM or more for up to 4 hours (SA F) or 6 hours (WHFIB). There was no increase in the MISO enhancement ratio (SER) in the SA F for a 4 hour exposure to MISO relative to that following a single injection. In the WHFIB tumor, the ER increased from 2.2 for a single MISO injection to 2.5 for a 4 hour contact with MISO for tumor growth delay, and from 2.1 to 2.3 for a cloning assay. Prolonged contact with MISO was toxic and reduced the body temperature by 4 to 5/sup 0/C. For WHFIB cells in vitro, when the contact time (in hypoxia) with 2.5 mM MISO was increased from 0.5 to 2.5 hours, the ER increased from 2.1 to 2.9 at 37/sup 0/C and from 1.9 to 2.5 at 33/sup 0/C.

  6. Life-Cycle Water Impacts of U.S. Transportation Fuels

    E-Print Network [OSTI]

    Scown, Corinne Donahue

    2010-01-01T23:59:59.000Z

    Drinking Water: Methyl Tertiary Butyl Ether (MTBE).http://www.epa.gov/mtbe/water.htm (11/30/10), Chiu, Y. W. ;LCFS LCI LP LPG MED MRO MSF MTBE MWD MWDOC NAICS NERC NETL

  7. 01 June 2006HME-HS Strategy and Architecture1 Aurora Industry DayAurora Industry Day

    E-Print Network [OSTI]

    CEV-1 Sub orbital space tourism Test flight Clipper HOPE Test flight of reusable vehicle ·Data relay Last update: 20 April 2006 2025202020152012201020082006 MRO Phoenix #12;01 June 2006HME

  8. PRE-STUDY COMMENTS OF IOWA UTILITIES BOARD ON DOE 2012 ELECTRIC...

    Broader source: Energy.gov (indexed) [DOE]

    should be considered in the DOE study. There are two utilities in Iowa that own transmission lines - MidAmerican, and ITC Midwest LLC (ITCM). MISO has operational control of...

  9. Comparative distribution of misonidazole and its amine metabolite in female Swiss Webster mice

    SciTech Connect (OSTI)

    Born, J.L.; Hadley, W.M.

    1985-06-01T23:59:59.000Z

    The distribution of misonidazole and its terminal reduction product 1-(2-amino-1-imidazolyl)-3-methoxy-2-propanol (misoamine) were compared in female Swiss Webster mice to determine if either misonidazole or misoamine is distributed to peripheral nerves. Female Swiss Webster mice received a 100 mg/kg (5 ..mu..Ci/..mu..mole) i.p. dose of either /sup 3/H-misonidazole or /sup 3/H-miso-amine and the distribution of radioactivity was determined in various tissues including sciatic nerves and other myelinated nerves. Misonidazole produced higher initial tissue concentrations of radioactivity than did miso-amine. The relative tissue concentrations of radioactivity produced by misonidazole or miso-amine were similar, although not identical, 48 hours after administration of the drugs. Both sciatic and other myelinated nerves were found to retain radioactivity following the administration of either misonidazole or miso-amine.

  10. Effect of vitamin B/sub 6/ on the neurotoxicity and pharmacology of desmethylmisonidazole and misonidazole: clinical and laboratory studies

    SciTech Connect (OSTI)

    Coleman, C.N.; Hirst, V.K.; Brown, D.M.; Halsey, J.

    1984-08-01T23:59:59.000Z

    The clinical usefulness of misonidazole (MISO) and desmethylmisonidazole (DMM) is severely limited by neurotoxicity. Based on theoretical considerations and on laboratory data suggesting that pyridoxine (PN) decreased MISO toxicity in mice. The authors attempted to ameliorate the clinical neuropathy of DMM using oral PN. Pharmacokinetic analysis suggested interaction of PN and DMM but no protection against neuropathy was observed. Serial experiments with C3H and BALB/c mice were done using various forms of vitamin B/sub 6/ (PN, pyridoxal, pyridoxal phosphate) administered orally and i.p. No consistent protection was observed. Dexamethasone did not alter MISO toxicity in mice, contrary to the clinical findings. They conclude that vitamin B/sub 6/ is not useful in preventing clinical neurotoxicity of MISO or DMM.

  11. Midwest Independent System Operator (Multiple States)

    Broader source: Energy.gov [DOE]

    Midwest Independent Transmission System Operator (MISO) is a Regional Transmission Organization, which administers wholesale electricity markets in all or parts of 11 U.S. states and the Canadian...

  12. SMALL PLATES TODAY'S SOUP 5

    E-Print Network [OSTI]

    Martin, Jeff

    baba ganoush EGG SALAD 9 Nature's Farm Smart Eggs · lettuce · Bothwell cheddar · celery · onions #12 back ribs house miso chili glaze fresh slaw rice CHICKEN 19 chicken breast mashed potatoes

  13. Decision Models for Bulk Energy Transportation

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    : · MISO (St. Paul/Carmel ­ Dale Osborn/Paul Gribik) · PJM (Philadelphia - Ott/Ford) · Iowa utility board dissemination on their website: · www.pjm.org is probably the very best for information · www

  14. Mass Market Demand Response and Variable Generation Integration Issues: A Scoping Study

    E-Print Network [OSTI]

    Cappers, Peter

    2012-01-01T23:59:59.000Z

    Analysis. Presentation given to PJM Interconnection Markete.g. , ISO-NE, NYISO, PJM, MISO, ERCOT, and CAISO). Co-also elect to participate in PJM’s day-ahead and/or real-

  15. Field Testing of Automated Demand Response for Integration of Renewable Resources in California's Ancillary Services Market for Regulation Products

    E-Print Network [OSTI]

    Kiliccote, Sila

    2013-01-01T23:59:59.000Z

    of the Market Report: New York ISO. 2010. PJM, State of theMarket Report for PJM: Ancillary Service Markets. 2010Maryland Interconnection (PJM) and Midwest ISO (MISO) all

  16. Renewable Portfolio Standards in the United States - A Status Report with Data Through 2007

    E-Print Network [OSTI]

    Wiser, Ryan

    2008-01-01T23:59:59.000Z

    LSE MISO M-RETS MSW MW MWh PJM POU PRC PSC PUC PV REC RPSelectric service provider PJM Generation Attributes Trackingwaste megawatt megawatt-hour PJM Interconnection publicly

  17. DECODE-AND-FORWARD RELAY BEAMFORMING FOR SECRECY WITH IMPERFECT CSI AND MULTIPLE EAVESDROPPERS

    E-Print Network [OSTI]

    Chockalingam, A.

    the eavesdropper gets no information while the intended receiver gets the information reliably. Wyner's work perfect knowledge of channel state information (CSI); SISO [4], [5], SIMO [6], MISO [7]- [9], and MIMO [10

  18. SUBMITTED TO IEEE TRANS. WIRELESS COMMNS., NOV. 2009 1 An Orthogonal Relay Protocol with Improved

    E-Print Network [OSTI]

    Adve, Raviraj

    the reliability of data transmission over wireless fading channels. In orthogonal relay protocols the source for the half-duplex relay channel is same as that of an equivalent multiple-input single-output (MISO) channel

  19. Cooperative Multiplexing in the Multiple Antenna Half Duplex Relay Channel

    E-Print Network [OSTI]

    Nikolic, Borivoje

    to improve the reliability and throughput of wireless commu- nication. While recent work has shown that relay MISO DMT bound has recently been shown [5] to be achievable. In this paper we study the DMT

  20. Energy-Efficient Clustering/Routing for Cooperative MIMO Operation in Sensor Networks

    E-Print Network [OSTI]

    Krunz, Marwan M.

    . The transmission mode can be one of four transmit/receive configurations: 1 × 1 (SISO), 2 × 1 (MISO), 1 × 2 (SIMO research. Diversity gain can be used to improve link reliability (i.e., lower the BER), extend the comm

  1. IOWA STATE UNIVERSITY Department of Economics

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    : namely, CAISO, ERCOT, ISO-NE, MISO, NYISO, PJM, and SPP. Over the years, however, a variety definitions omit many services important for ensuring the efficient and reliable operation of power systems

  2. 912 IEEE COMMUNICATIONS LETTERS, VOL. 17, NO. 5, MAY 2013 Decode-and-Forward Relay Beamforming for

    E-Print Network [OSTI]

    Chockalingam, A.

    security through physical layer mechanisms, where the intended receiver gets the information reliably while powers has been reported for multiple-input single-output (MISO) channels. It has been further shown

  3. Decentralized Power Control with Two-way Training for Multiple Access

    E-Print Network [OSTI]

    Bhashyam, Srikrishna

    to a single receiver, multiple antenna systems have been employed to increase reliability or the supported and nearly a two-fold improvement at all multiplexing gains. The MISO (Multiple Input Single Output) model

  4. Space-Time Block Coding for Frequency-Selective and Time-Varying Channels

    E-Print Network [OSTI]

    Langendoen, Koen

    such as channel capacity and reliability [2]. Space-time block coding (STBC) [3], [4] has been introduced for a multiple-input single-output (MISO) system with 2 transmit antennas and 1 receive antenna

  5. Linear Processing for the Downlink in Multiuser MIMO Systems with Multiple Data Streams

    E-Print Network [OSTI]

    Adve, Raviraj

    the reliability and data rate of a transmission. More recently, researchers have investigated using downlink problem with individual SINR constraints in a multiple-input single-output (MISO) system, i

  6. Statistically Adaptive Spatial Multiplexing for Time-varying Correlated MIMO Channels

    E-Print Network [OSTI]

    Sayeed, Akbar M.

    decreases according to the order MIMO>{MISO, SIMO}>SISO and decreases for fewer antennas in each case. Index and reliability of wireless communication links and are often referred to as multiple-input multiple- output (MIMO

  7. Software Implementation of Spatial Interweave Cognitive Radio Communication using

    E-Print Network [OSTI]

    Gesbert, David

    for a CR system in which a multiple-input single-output (MISO) secondary link, wants to opportunistically with antenna coupling effects, it is possible to find reliable calibration parameters. The same authors

  8. Deploy IBM DB2 pureScale feature on IBM Power Benefit from the shared disk architecture of DB2 pureScale

    E-Print Network [OSTI]

    of DB2 pureScale Skill Level: Intermediate Miso Cilimdzic (cilimdzi@ca.ibm.com) DB2 Performance Manager Tivoli® System Automation for Multiplatforms (Tivoli SA MP) software · IBM Reliable Scalable Clustering

  9. DOI:01.IJCOM.02.03. ACEEE Int. J. on Communication, Vol. 02, No. 03, Nov2011

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    improves reliability and transmission rates achievable in wireless systems [1­6], the improvement comes-varying optimal antenna subset. Early work on antenna selection focused on selection in MISO/SIMO systems

  10. Oscar Bejarano Department of Electrical and Computer Engineering

    E-Print Network [OSTI]

    -antennaResearch Interests systems exploiting Multi-User Beamforming and virtual MISO techniques. Ph.D., Electrical portable and reliable wiring systems for testing areas · Developed product testing computer programs

  11. BEAMFORMING MAXIMIZES THE RANK ONE RICEAN MIMO COMPOUND CAPACITY Ami Wiesel, Yonina C. Eldar and Shlomo Shamai (Shitz)

    E-Print Network [OSTI]

    Eldar, Yonina

    The use of multiple transmit and receive antennas is known to improve the capacity and reliability output (MISO) channel was considered. In this work, the structure of the The authors were supported

  12. Bit-Interleaved Coded Multiple Beamforming with Imperfect CSIT

    E-Print Network [OSTI]

    Ayanoglu, Ender

    systems, with an increase in reliability and spectral efficiency [3], [4], [5]. While the advantages beamforming in a multi-input single-output (MISO) setting where they designed codebooks via the generalized

  13. Maximizing Sum Rate and Minimizing MSE on Multiuser Downlink: Optimality, Fast Algorithms

    E-Print Network [OSTI]

    Chiang, Mung

    -Input-Single-Output (MISO) channel, where the transmitter (at the base station) is equipped with an antenna array and each, e.g., increasing the total throughput (sum rates) or the total reliability in the system. Joint

  14. Cooperative Network Coding Next Generation Technology for Today's Warfighter

    E-Print Network [OSTI]

    Haas, Zygmunt J.

    Communications to produce superior network reliability and provide inherent security features, while improving it towards the next cluster. 3.Nodes, in cluster 2 through K, receive the combination packets and act as MISO

  15. On Stochastic Feedback Control for Multi-antenna Beamforming: Formulation and Low-Complexity

    E-Print Network [OSTI]

    Liang, Ben

    for transmit beam- forming in multiple-input-single-output (MISO) systems, and design practical implementation and reliability over a wireless link in a slow fading environ- ment [1]. The actual beamforming gain achieved

  16. 2003 4th IEEE Workshop on Signal Processing Advances in Wireless Communications

    E-Print Network [OSTI]

    Vázquez, Gregori

    will include multiple antenna to increase the link capacity or reliability [l]. In these systems, spatial-output (MISO) communication system. Specifically, we consider that the transmitted signal is space-time coded

  17. IEEE TRANSACTIONS ON SIGNAL PROCESSING, VOL. 60, NO. 10, OCTOBER 2012 1 Max-Min SINR Coordinated Multipoint Downlink

    E-Print Network [OSTI]

    Tan, Chee Wei

    , we study the multiple-input-single-output (MISO) transmit beamforming and power control problem. We links to enhance the reliability of the links between mobile users and the serving base station

  18. 1 GEP problem development 1.1 Simple GEP statement

    E-Print Network [OSTI]

    McCalley, James D.

    is used to identify the percentage of a windfarm's capacity which should be identified for reliability, MISO was using 13.3% capacity credit for wind [1]. Capacity credits for solar are generally higher

  19. Unquantized and Uncoded Channel State Information Feedback in Multiple Antenna Multiuser Systems

    E-Print Network [OSTI]

    Mandayam, Narayan

    channels, auto re- gressive process, MMSE receiver, spatial pre-filtering, MISO systems. This work theoretic sense) for it to be reliable? Are there ways to mitigate the delay (which is theoretically

  20. 802.11 with Multiple Antennas for Dummies Daniel Halperin

    E-Print Network [OSTI]

    Wetherall, David

    . It is responsible for superior performance, reliability and range. In this tu- torial, we provide a brief that uses one transmit antenna and one receive antenna. SIMO and MISO systems also exist, as we will see

  1. IEEE TRANSACTIONS ON SIGNAL PROCESSING, VOL. 59, NO. 10, OCTOBER 2011 5013 Solutions for the MIMO Gaussian Wiretap Channel

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    the general MIMO case, and is not restricted to SISO or MISO scenarios. Index Terms--Cooperative jamming capacity, which quantifies the maximum rate at which a transmitter can reliably send a secret message

  2. On-Line Fault Diagnosis of Dynamic Systems via Robust Parameter Identification Gerard Blocha

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    of faults, their isolation and their identification is presented. The systems considered are MISO systems the individual reliability of the different pieces of equipment, and by developing systematic preventive mainte

  3. Dirty Paper Coding Versus Linear GSVD-Based Precoding in MIMO Broadcast Channel with

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    the maximum rate at which a transmitter can reliably send a secret message to the receiver, without-output (MISO) Gaussian case, and [4] considered the general MIMO Gaussian case. It was shown in [4] that, under

  4. MIMO Time Reversal Communications Hee-Chun Song

    E-Print Network [OSTI]

    Zhou, Shengli

    Keywords: Time reversal mirror, MIMO 1. INTRODUCTION Reliable, high data rate acoustic communications correspond to the downlink (from the base station to a user, MISO) and the uplink (from a user to a base

  5. IEEE TRANSACTIONS ON SIGNAL PROCESSING, VOL. 59, NO. 12, DECEMBER 2011 6127 Maximizing Sum Rate and Minimizing MSE on

    E-Print Network [OSTI]

    Tan, Chee Wei

    . INTRODUCTION WE consider multiuser downlink transmission on a mul- tiple-input-single-output (MISO) channel Object Identifier 10.1109/TSP.2011.2165065 rates) or the total reliability in the system. Joint

  6. IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS, VOL. 31, NO. 9, SEPTEMBER 2013 1701 On the Optimality of Linear Precoding for

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    the maximum rate at which a transmitter can reliably send a secret message to a receiver, without were established. Further work in [3] studied the multiple-input single-output (MISO) Gaussian case

  7. 3196 IEEE TRANSACTIONS ON COMMUNICATIONS, VOL. 58, NO. 11, NOVEMBER 2010 Space Shift Keying (SSK) Modulation with Partial

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    information for optimal receiver design. This latter result highlights the importance of accurate and reliable Terms--Spatial modulation (SM), space shift keying (SSK) modulation, multiple-input-single-output (MISO

  8. Performance of Closed Form and Iterative MU-MIMO Precoders for Different Broadcast

    E-Print Network [OSTI]

    Gesbert, David

    in improving both reliability and capacity of the system. Some theoretical analysis of the capacity, and Hassibi) algorithm proposed in [12] as it is an iterative algorithm for MU-MISO sumrate maximization based

  9. Efficient Feedback Signaling using Multi-Channel Selection Diversity

    E-Print Network [OSTI]

    Gesbert, David

    -input multiple-output (MIMO) systems have been one of key techniques to achieve high rate and high reliability for the multiple-input single-output (MISO) BC is obtained by applying the Costa precoding at the transmitter

  10. 1186 IEEE TRANSACTIONS ON INFORMATION THEORY, VOL. 54, NO. 3, MARCH 2008 DiversityMultiplexing Tradeoff and Outage

    E-Print Network [OSTI]

    Lee, Yong Hoon

    is derived. The DMT and outage performance are also analyzed for Rician mul- tiple-input­single-output (MISO- icantly improve link reliability by transmit diversity such as space­time coding [4], [5]. However

  11. Application for Presidential Permit OE Docket No. PP-230-4 Internation...

    Broader source: Energy.gov (indexed) [DOE]

    to NISO from MISO and IESO 10-13-11.pdf More Documents & Publications Application for Presidential permit OE Docket No. PP-230-4 International Transmission Company: Comments...

  12. 2011 Wind Technologies Market Report

    E-Print Network [OSTI]

    Bolinger, Mark

    2013-01-01T23:59:59.000Z

    kilowatt-hour Midwest Independent System Operator megawattPJM), Midwest Independent System Operator (MISO), New YorkN/A (NSP) Midwest Independent System Operator N/A N/A (

  13. Midwest Transmission Workshop II Summary

    SciTech Connect (OSTI)

    Kevin Bryan

    2002-12-05T23:59:59.000Z

    OAK-B135 After introductions of all participants, Abby Arnold, RESOLVE, reviewed the purpose of the meeting and the agenda. The purpose of the workshop was to share the results of the Midwest Independent System Operator (MISO) scenario development for wind and other fuel sources and the corresponding implications for transmission throughout the MISO control area. The workshop agenda is included in Attachment A.

  14. Synthesis of [F-18] fluoroetanidazole for hypoxia imaging evaluation

    SciTech Connect (OSTI)

    Lim, J.L.; Berridge, M.S. [Case Western Reserve Univ., Cleveland, OH (United States)]|[Univ. Hospitals of Cleveland, OH (United States)

    1994-05-01T23:59:59.000Z

    Recently there has been an increased interest in new imaging markers for hypoxia. Among them misonidazole (MISO) derivatives based on the 2-nitro-imidazole ring have received considerable attention. Previous studies have shown that MISO was metabolically trapped in living hypoxic cells. Its fluorinated derivative, FMISO, when labeled with F-18 and used for PET represented a promising means of detection of hypoxia in tumors and in ischemic heart and brain.

  15. EE6170 Intro. to Wireless & Cellular Communications Problem Set 5 March 30, 2012

    E-Print Network [OSTI]

    Bhashyam, Srikrishna

    capacity at 0 dB and 10 dB SNR for an outage probability 0.1. 4. (T & V 5.15) Consider the MISO channel is zero mean and has a covariance matrix Kx . Argue that the maximum achievable reliable rate of com}U. 5. (T & V 5.16) Above problem shows that for the i.i.d. Rayleigh slow fading MISO channel, one can

  16. Depletion of glutathione in vivo as a method of improving the therapeutic ratio of misonidazole and SR 2508. [BSO; DEM

    SciTech Connect (OSTI)

    Yu, N.Y.; Brown, J.M.

    1984-08-01T23:59:59.000Z

    Depletion of intracellular glutathione (GSH) can enhance misonidazole (MISO) radiosensitizing efficacy both in vivo and in vitro. However, such treatments may also enhance the systemic toxicity in animals. The purpose of the present study was to test various ways of depleting GSH levels in a variety of experimental mouse tumors, to measure the improvement in the efficacy of MISO and its less toxic analog SR 2508 by this depletion, and to determine the effect of daily GSH depletion on the toxicity MISO and SR 2508. GSH levels were measured daily for 5 days in tumors, livers and brains of mice injected daily with buthionine sulfoximine (BSO), with or without diethylmaleate (DEM). Daily doses of BSO depleted tumor levels of GSH to 20 to 40% of controls by 6 hr after each injection. Injection of DEM 6 hr after BSO further enhanced the depletion. Administration of MISO or SR 2508 at the time of maximum GSH depletion enhanced the MISO efficacy by factors of 2.6 to 8 for depletion to 8% of controls by BSO + DEM, but no enhancement of SR 2508 was seen with tumors at 20% GSH levels achieved with BSO alone in the preliminary experiment. The chronic toxicity of MISO was enhanced not at all or by a factor of up to 2 for BSO and BSO + DEM respectively.

  17. Development progress of the Materials Analysis and Particle Probe

    SciTech Connect (OSTI)

    Lucia, M., E-mail: mlucia@pppl.gov; Kaita, R.; Majeski, R.; Boyle, D. P.; Schmitt, J. C.; Onge, D. A. St. [Princeton Plasma Physics Laboratory (PPPL), Princeton, New Jersey 08543 (United States); Bedoya, F.; Allain, J. P. [Department of Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana-Champaign (UIUC), Urbana, Illinois 61801 (United States)

    2014-11-15T23:59:59.000Z

    The Materials Analysis and Particle Probe (MAPP) is a compact in vacuo surface science diagnostic, designed to provide in situ surface characterization of plasma facing components in a tokamak environment. MAPP has been implemented for operation on the Lithium Tokamak Experiment at Princeton Plasma Physics Laboratory (PPPL), where all control and analysis systems are currently under development for full remote operation. Control systems include vacuum management, instrument power, and translational/rotational probe drive. Analysis systems include onboard Langmuir probes and all components required for x-ray photoelectron spectroscopy, low-energy ion scattering spectroscopy, direct recoil spectroscopy, and thermal desorption spectroscopy surface analysis techniques.

  18. Partial hypoxia as a cause of radioresistance in a human tumor xenograft: its influence illustrated by the sensitizing effect of misonidazole and hyperbaric oxygen

    SciTech Connect (OSTI)

    Reynaud-Bougnoux, A.; Lespinasse, F.; Malaise, E.P.; Guichard, M.

    1986-08-01T23:59:59.000Z

    While previous studies with three human tumor xenografts suggest that contact-resistance plays a major role in the response of these tumors to radiation, it remains possible that partial hypoxia may provide an alternate explanation. The present study was carried out to check this possibility by investigating the influence of misonidazole (MISO) and hyperbaric oxygen (HBO) on both the initial and distal components of the survival curves of HRT18 tumor cells. The effect of a challenge dose of radiation on the initial radioresistance of this tumor was also studied. To assess the effects of MISO and HBO, tumor cell survival was determined by excision assay in two groups of tumor-bearing mice, one given MISO (1 mg/g body weight, i.p.) 45 min before irradiation and the other exposed to HBO (3.5 bars). MISO treatment caused greater sensitization than HBO. The enhancement ratios at the 5.10(-1) level were 1.7 (MISO) and 1.7 (HBO); at the 10(-1) level, they were 1.6 (MISO) and 1.4 (HBO); while at 10(-2), they were 1.6 (MISO) and 1.4 (HBO). These two sensitizing effects favor the hypothesis that solid tumors contain a compartment of partially hypoxic cells. To study the effect of a challenge radiation dose on initial radioresistance, tumors were given a challenge dose of 8 Gy, followed 24-48 hr later by doses ranging from 2-12 Gy. The challenge dose did not modify the shape of the survival curve.

  19. Hypoxic cell radiosensitizers: expectations and progress in drug development

    SciTech Connect (OSTI)

    Coleman, C.N.

    1985-02-01T23:59:59.000Z

    When misonidazole (MISO) was introduced into clinical trials there were great expectations that the cure rate of many tumors would be dramatically increased. The lack of efficacy of MISO discouraged further studies with hypoxic cell sensitizers. In recent years superior sensitizers SR 2508 and RO-03-8799 have been introduced into the clinic. SR 2508 is less neurotoxic than MISO, allowing more than three times the total amount of drug to be administered. Furthermore, based on the analysis of a patient's plasma pharmacokinetic profile, neurotoxicity may be largely avoidable. RO-03-8799 is superior in that it produces a higher sensitizer enhancement ratio than MISO for the same administered dose. Unlike with MISO and SR 2508, the dose of RO-03-8799 that can be administered is limited by acute toxicity with no cumulative toxicity having yet been encountered. Study design has improved and the expected clinical benefit from sensitizers has been clarified. Sensitizers, like particle radiation therapy and hyperthemia will, if successful, effect the rate of local tumor control, but cannot improve the cure rate of patients with preexisting metastatic disease. Taking into account the need to optimize reoxygenation, the various reasons for tumor radioresistance other than hypoxia, and the lower oxygen and sensitizer enhancement ratios at 200 cGy per fraction, it is likely that sensitizers will provide some clinical benefit for patients with selected tumor types.

  20. Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers

    SciTech Connect (OSTI)

    Shibamoto, Y.; Nishimoto, S.; Shimokawa, K.; Hisanaga, Y.; Zhou, L.; Wang, J.; Sasai, K.; Takahashi, M.; Abe, M.; Kagiya, T.

    1989-04-01T23:59:59.000Z

    Types of 2-nitroimidazoles and 3-nitro-1,2,4-triazoles bearing one or two fluorine atoms on their side chains were synthesized to evaluate their physicochemical properties, radiosensitizing effects, and toxicity. The reduction potential of the compounds containing one fluorine was similar to that of misonidazole (MISO), whereas that of the difluorinated compounds was slightly higher. Both mono- and difluorinated compounds had an in vitro sensitizing activity comparable to or slightly higher than that of MISO. The fluorinated 3-nitrotriazoles were almost as efficient as the 2-nitroimidazoles with the same substituent. In vivo, some of the compounds were up to twice more efficient than MISO, whereas others were as efficient as MISO. Toxicity in terms of LD50/7 in mice was quite variable depending on the side-chain structure; the amide derivatives were less toxic than MISO, whereas the alcohol and ether derivatives were more toxic. In view of the radiosensitizing effect and toxicity in vivo, at least one compound, KU-2285 (a 2-nitroimidazole with an N1-substituent of: CH2CF2CONHCH2CH2OH) has been found to be as useful a hypoxic cell sensitizer as SR-2508.

  1. Pharmacokinetics and toxicology of continuously infused nitroimidazoles

    SciTech Connect (OSTI)

    Eifel, P.J.; Brown, J.M.

    1984-08-01T23:59:59.000Z

    The pharmacokinetics and toxicology of misonidazole (MISO) and SR-2508 given by continuous intraperitoneal infusion were studied in female C/sub 3/H mice. The survival (time to death) of animals receiving continuous infusions of SR-2508 and MISO was compared and related to plasma concentration, rate of infusion and total amount of drug delivered. Brain and plasma concentrations were determined by HPLC. For SR-2508, plasma concentration was directly proportional to the infusion rate. However, as the infusion rate of MISO was doubled, the plasma concentration of MISO increased approximately 6-fold, reflecting a substantial increase in the apparent half-life. The brain/plasma concentration ratio in animals infused for up to 6 days with SR-2508 remained constant, at approximately 0.09. At plasma concentrations of 0.08-1.5 mM, animals receiving SR-2508 survived approximately 3 times as long as animals exposed to a comparable plasma concentration of MISO. Even at the lowest infusion rates employed in this study, the survival of mice receiving SR-2508 was much shorter than would have been predicted if the toxicity of these two drugs were solely related to the integral brain exposure. The low brain/plasma concentration ratio of SR-2508 was maintained throughout long continuous exposures.

  2. Initial pharmacology and toxicology of intravenous desmethylmisonidazole

    SciTech Connect (OSTI)

    Coleman, C.N. (Stanford Univ., CA); Wasserman, T.H.; Phillips, T.L.; Strong, J.M.; Urtasun, R.C.; Schwade, J.G.; Johnson, R.J.; Zagars, G.

    1982-03-01T23:59:59.000Z

    Since January 1981, 52 patients have entered the Radiaton Therapy Oncology Group Phase I trial with intravenous (i.v.) desmethylmisonidazole (DMM). DMM is less lipophilic than misonidazole (MISO) and theoretically will be less neurotoxic due to lower penetration into neural tissue and more rapid elimination. The drug is administered intravenously to achieve the maximum drug concentration in tumor for a given dose. The protocol slowly escalates the total dose of drug administered. At this time the planned dose on the three week schedule is 1 g/m/sup 2/ twice weekly to a total dose of 17.5g/m/sup 2/. The preliminary plasma pharmacokinetic data demonstrates high peak plasma levels within five minutes of the end of the drug infusion. Compared to MISO the percent of DMM excreted in the urine is increased, 63% vs 10%, and the elimination half-life is decreased: DMM, i.v. 5.3h; MISO, i.v. 9.3h; MISO, oral 10 to 13h. Neurotoxicity has been observed in approximately 30% of patients given a cumulative dose of >11g/m/sup 2/. This is in comparison to a 50% incidence in RTOG Phase 1 study with oral MISO at doses of 12g/m/sup 2/. There is not sufficient data to evaluate the relationship between neurotoxicity and drug exposure. Further patient accrual on this study is required to better define the properties of DMN.

  3. Effects of glutathione depletion by buthionine sulfoximine on radiosensitization by oxygen and misonidazole in vitro

    SciTech Connect (OSTI)

    Shrieve, D.C.; Denekamp, J.; Minchinton, A.I.

    1985-06-01T23:59:59.000Z

    Buthionine sulfoximine (BSO) has been used to deplete glutathione (GSH) in V79-379A cells in vitro, and the effect on the efficiency of oxygen and misonidazole (MISO) as radiosensitizers has been determined. Treatment with 50 or 500 ..mu..M BSO caused a rapid decline in GSH content to less than 5% of control values after 10 hr of exposure. Removal of BSO resulted in a rapid regeneration of GSH after 50 ..mu..M BSO, but little regeneration was observed over the subsequent 10-hr period after 500 ..mu..M. Cells irradiated in monolayer on glass had an oxygen enhancement ratio (OER) of 3.1. After 10-14 hr pretreatment with 50 ..mu..M BSO, washed cells were radiosensitized by GSH depletion at all oxygen tensions tested. The OER was reduced to 2.6, due to greater radiosensitization of hypoxic cells than aerated ones by GSH depletion. In similar experiments performed with MISO, an enhancement ratio of 2.0 could be achieved with 0.2 mM MISO in anoxic BSO-pretreated cells, compared to 2.7 mM MISO in non-BSO-treated cells. These apparent increases in radiosensitizer efficiency in GSH-depleted cells could be explained on the basis of radiosensitization of hypoxic cells by GSH depletion alone. These results are consistent with hypoxic cell radiosensitization by GSH depletion and by MISO or oxygen acting by separate mechanisms.

  4. In vivo radiosensitizing effect of nitroimidazole derivative KIN-804

    SciTech Connect (OSTI)

    Tada, Takuhito (Osaka-Prefectural Habikino Hospital, Habikino-City (Japan) Osaka City Univ. Medical School (Japan)); Nakajima, Toshifumi; Onoyama, Yasuto (Osaka City Univ. Medical School (Japan)); Murayama, Chieko; Mori, Yomoyuki (Tokai Univ. School of Medicine (Japan)); Nagasawa, Hideko (Keio Univ., Tokyo (Japan)); Hori, Hitoshi (Tokushima Univ. (Japan)); Inayama, Seiichi (Keio Univ., Tokyo (Japan) Tokushima Univ. (Japan))

    1994-06-15T23:59:59.000Z

    In vivo characteristics of 2-nitroimidazole-1-methylacetohydroxamate (KIN-804), which is a newly developed hypoxic cell radiosensitizer, are presented. The toxicity, pharmacokinetics, and radiosensitizing effect of KIN-804 were studied by in vivo experiments using C3H/He mice bearing the SCCVII tumor. Results were compared with misonidazole (MISO). LD[sub 50]7 of KIN-804 and MISO were 3200 mg/kg and 2000 mg/kg, respectively. The peak concentration of KIN-804 in the tumor occurred 20 min after intraperitoneal injection and reached about 62% of the maximum concentration in the blood. The concentrations in brain and sciatic nerve were very low and clearance from sciatic nerve was rapid. Enhancement ratios of KIN-804 calculated using the growth delay method were 1.22, 1.50, and 1.71 at doses of 50, 100, and 200 mg/kg, respectively, compared with 1.36 for MISO at a dose of 100 mg/kg. In the TCD[sub 50] assay, enhancement ratios at a dose of 200 mg/kg were 1.69 for KIN-804 and 1.52 for MISO, respectively. KIN-804 is a promising radiosensitizer since it shows less toxicity and higher radiosensitizing activity than MISO. 10 refs., 5 figs.

  5. Misonidazole combined with hyperfractionation in the management of malignant glioma

    SciTech Connect (OSTI)

    Fulton, D.S.; Urtasun, R.C.; Shin, K.H.; Geggie, P.H.S.; Thomas, H.; Muller, P.J.; Moody, J.; Tanasichuk, H.; Mielke, B.; Johnson, E.

    1984-09-01T23:59:59.000Z

    Multiple daily fractionated radiation therapy (MDF) may be more effective than conventionally fractionated radiation therapy (CF) in the treatment of malignant glioma. The hypoxic cell sensitizer misonidazole (MISO) could be more effective when employed with small fractions of radiation every 4 hours to take advantage of the long half-life of the drug. To evaluate MDF and MDF in combination with MISO, a randomized prospective trial was initiated. Between January 1981, and December 1982, patients with histologically verified astrocytoma with anaplastic foci or glioblastoma multiforme were randomized to CF, MDF and MDF in combination with MISO. In January 1983, the CF arm was dropped and a high dose MDF arm added. CCNU chemotherapy was given at the time of tumor progression. Median survival was 29 weeks for CF, 45 weeks for MDF and 50 weeks for MDF plus MISO. Survival was significantly improved for patients treated with MDF compared to patients treated with CF. The addition of MISO to MDF did not result in further improvement in survival. Acute toxicity was acceptable.

  6. Potentiation of melphalan activity in the KHT sarcoma by the radiosensitizer RSU 1069

    SciTech Connect (OSTI)

    Siemann, D.W.; Maddison, K.; Wolf, K.

    1984-09-01T23:59:59.000Z

    The radiation sensitizer misonidazole (MISO) has been shown to potentiate the cytotoxic action of a variety of anti-cancer agents. Even larger enhancement ratios than those observed with MISO have been found with certain other nitroimidazoles. One agent reported to be particularly effective in combination with the chemotherapeutic agent melphalan is the sensitizer RSU 1069. The present studies therefore were designed to evaluate the effect of combining these two agents in the treatment of intramuscularly growing KHT sarcomas. Tumor response was assessed using an in vivo to in vitro clonogenic cell survival assay. When given at times ranging from 60 min before to 30 min after melphalan exposure, RSU 1069 was found to increase the tumoricidal activity of the chemotherapeutic agent. Complete dose response curves combining RSU 1069 and a range of melphalan doses then were determined. For comparison the effects of combining MISO or benznidazole (BENZO) with melphalan also were evaluated. When combined with melphalan, doses of RSU 1069, BENZO and MISO were found to yield dose modifying factors of 1.6, 1.5, and 1.4, respectively. These results indicate that potentiation of melphalan activity occurs at RSU 1069 doses which are approximately 10-fold lower than those of MISO, making this sensitizer as effective a potentiator of melphalan as so far tested in the KHT sarcoma.

  7. The potential impacts of a competitive wholesale market in the midwest: A preliminary examination of centralized dispatch

    SciTech Connect (OSTI)

    Lesieutre, Bernard C.; Bartholomew, Emily; Eto, Joseph H.; Hale, Douglas; Luong, Thanh

    2004-07-01T23:59:59.000Z

    In March 2005, the Midwest Independent System Operator (MISO) will begin operating the first-ever wholesale market for electricity in the central and upper Midwestern portion of the United States. Region-wide, centralized, security-constrained, bid-based dispatch will replace the current system of decentralized dispatch by individual utilities and control areas. This report focuses on how the operation of generators may change under centralized dispatch. We analyze a stylized example of these changes by comparing a base case dispatch based on a ''snapshot'' taken from MISO's state estimator for an actual, historical dispatch (4 p.m., July 7, 2003) to a hypothetical, centralized dispatch that seeks to minimize the total system cost of production, using estimated cost data collected by the EIA. Based on these changes in dispatch, we calculate locational marginal prices, which in turn reveals the location of congestion within MISO's footprint, as well as the distribution of congestion revenues. We also consider two sensitivity scenarios that examine (1) the effect of changes in MISO membership (2003 vs. 2004 membership lists), and (2) different load and electrical data, based on a snapshot from a different date and time (1 p.m., Feb. 18, 2004). Although our analysis offers important insights into how the MISO market could operate when it opens, we do not address the question of the total benefits or costs of creating a wholesale market in the Midwest.

  8. Composite Interfaces, Vol. 12, No. 1-2, pp. 125140 (2005) Also available online -www.vsppub.com

    E-Print Network [OSTI]

    with Fourier transform infrared (FTIR) spectroscopy. After it was heated at 180 C for 5 min, the `activated-extracted remains with infrared (IR). It was reported To whom correspondence should be addressed. E-mail: johnzlu a hydrolyzed form to an anhydride form by heating. MAPP-treated wood fiber was extracted with toluene for 24 h

  9. EIS-0300: Minnesota Agri-Power Project: Biomass for Rural Development, Granite Falls, Minnesota

    Broader source: Energy.gov [DOE]

    This EIS analyzes DOE and the Minnesota Environmental Quality Boards' [MEQB, a Minnesota State agency] decision to support a proposal by the Minnesota Valley Alfalfa Producers (MnVAP) to construct and operate a 75–103 megawatt biomass fueled gasifier and electric generating facility, known as the Minnesota Agri-Power Plant (MAPP), and associated transmission lines and alfalfa processing facilities.

  10. RADIO CONTROL ADC0 (RSSI)

    E-Print Network [OSTI]

    5 5 4 4 3 3 2 2 1 1 D D C C B B A A RADIO CONTROL PCLK PDATA PALE RADIO DATA SPI_SCK SPI_MOSI SPI_MISO[0..7] PALE RF_DETECT US_OUT_EN SPI_MISO I2C_CLK I2C_DATA US_DETECT AC+ US_OUT SCK RSTN UART_RXD0/SS PB1/SCK PB2/MOSI PB3/MISO PB4/OC0 PB5/OC1A PB6/OC1B PB7/OC1C PC0/A8 PC1/A9 PC2/A10 PC3/A11 PC4/A12

  11. Binding of misonidazole to V79 spheroids and fragments of Dunning rat prostatic and human colon carcinomas in vitro: diffusion of oxygen and reactive metabolites

    SciTech Connect (OSTI)

    Franko, A.J.; Koch, C.J.

    1984-08-01T23:59:59.000Z

    Differences were noted previously in the binding of /sup 14/C-Misonidazole (MISO) to V79 and EMT6 spheroids when incubated at low oxygen levels. Further data reported here indicate that the K/sub m/ for the inhibition of binding by oxygen is lower in V79 than EMT6 spheroids, so that part of the non-uniformity of binding to V79 spheroids can be explained by diffusion of small amounts of oxygen through the entire rim of viable cells. Diffusion of reactive metabolites of MISO out of the spheroid previously was considered an unlikely explanation. Further evidence to support this interpretation is presented here. Patterns of binding of /sup 3/H-MISO to Dunning and human colon carcinomas are presented which are consistent with the interpretation that most of the reactive metabolites are confined to the cell in which they are produced.

  12. Clinical trials of radiosensitizers: what should we expect

    SciTech Connect (OSTI)

    Brown, J.M.

    1984-03-01T23:59:59.000Z

    The lack of positive results from the clinical trials undertaken so far with misonidazole (MISO) are widely considered as disappointing. This is leading to a growing sentiment that hypoxic cells may not be a significant limitation to local control of human tumors. To examine whether this is a reasonable conclusion, the relevant in vitro and in vivo data have been summarized so that predictions of the extent of radiosensitization of the hypoxic cells can be made from a knowledge of the clinically achievable levels of MISO. The in vitro and in vivo data with radiosensitizers suggest that only a small effect, if any, is likely to be demonstrated in the clinical trials with MISO, even for those tumors the control of which is limited by hypoxic cells. Thus the question of whether hypoxic cells may or may not limit the local control of tumors by radiotherapy has not been addressed adequately by the presently available radiosensitizing drugs.

  13. KIH-802: 2-nitroimidazole-1-acetohydroxamate as a hypoxic cell radiosensitizer

    SciTech Connect (OSTI)

    Hori, H.; Murayama, C.; Mori, T.; Shibamoto, Y.; Abe, M.; Onoyama, Y.; Inayama, S.

    1989-04-01T23:59:59.000Z

    We have identified potassium 2-nitroimidazole-1-acetohydroxamate (KIH-802) as a hypoxic cell radiosensitizer potentially superior to Miso. The water-soluble acetohydroxamates of 2-nitroimidazole (KIH-802; free acid 801) and 4-nitroimidazole (KIH-852) were designed, synthesized, and evaluated by in vitro and in vivo screening against EMT6 cells. Enhancement ratios of KIH-802 and 801 were 1.92 and 1.68, respectively, compared with 1.58 for MISO all at 1 mM. These acetohydroxamates are also expected to be more effective in vitro than SR-2508 based on our previous experiments. In vivo ERs of KIH-802, 801, and 852 were 1.75, 1.50, and 1.35, respectively, compared with 1.57 for MISO all at the same dose of 200 mg/kg. The data clearly show that the addition of an acetohydroxamic acid moiety to the 2-nitroimidazole skeleton can enhance radiosensitizing ability.

  14. Radical irradiation and misonidazole for T2 grade III and T3 bladder cancer: 2 year follow-up

    SciTech Connect (OSTI)

    Abratt, R.P.; Barnes, D.R.; Hammond, J.A.; Sarembok, L.A.; Tucker, R.D.; Williams, A.M.

    1984-09-01T23:59:59.000Z

    Patients with T2 grade III and T3 bladder cancer were treated in a Phase II trial of radical irradiation plus Misonidazole (MISO). Twenty-two patients were treated and the results compared with historical controls. The cystoscopic complete tumor response between 6 and 12 months post therapy were 73 and 43%, respectively. The patient two year survival was 81 and 51%, respectively, and the patient 2 year survival with bladder preservation was 61 and 48%, respectively - 4 patients in the MISO study having undergone salvage cystectomy. Complications that may be radiation related in the MISO study are would sepsis after salvage cystectomy in 2 patients, rectal stenosis requiriing colostomy 16 months after salvage cystecomy in 1 patient and the development of a contracted bladder in 1 patient with a history of prior extensive endoscopic therapy. No misonidazole neurotoxicity seen. These findings are being further evaluated in a prospective radomized trial.

  15. Eighth annual Juan del Regato lecture. Chemical modifiers of radiosensitivity--theory and reality: a review

    SciTech Connect (OSTI)

    Fowler, J.F.

    1985-04-01T23:59:59.000Z

    In this review the poor clinical gains from hyperbaric oxygen (HBO) and misonidazole (MISO) are discussed critically. The biggest factor reducing clinical gains is almost certainly reoxygenation. Other possible reasons include vasoconstrictive self-limitation of HBO and neurotoxicity of MISO, so that the radiosensitization of any hypoxic cells in human tumors was not adequate. Nevertheless, there have been some positive clinical results, so that hypoxic cells can sometimes be a problem in some tumors, especially those of the head and neck, even after multiple fraction radiotherapy. While hypoxic cell radioresistance is obviously only one form of radioresistance it is a large factor of resistance when hypoxic cells are present. Current developments are briefly reviewed: the new clinical sensitizers Ro-03-8799 and SR-2508 which should be 3 to 10 times more efficient than MISO if viable hypoxic cells are present; and methods of measuring which human tumors might have significant numbers of hypoxic viable cells. 77 references.

  16. Misonidazole with dexamethasone rescue: an escalating dose toxicity study

    SciTech Connect (OSTI)

    Tanasichuk, H.; Urtasun, R.C.; Fulton, D.S.; Raleigh, J.

    1984-09-01T23:59:59.000Z

    Neurotoxicity induced by misonidazole (MISO) and desmethylmisonidazole (DMM) has become the dose limiting factor in clinical work. In 1981, the authors reported a preliminary study suggestive that Dexamethasone (DEXA) does have a protective effect against peripheral neuropathies (PN) resulting from toxicity of misonidazole. The authors are presently investigating the use of DEXA, with escalating doses of MISO in an attempt to modify its neurotoxicity. To date, 16 patients have been registered to receive total doses of MISO given in 9 equally divided doses over 3 weeks. DEXA is given 3 days prior to the first dose and continues for the duration of therapy. All patients receive palliative radiation. No toxicity was seen at the total dose of 13.5 gm/M/sub 2/. One grade I PN occurred in the first four patients receiving 15.5 gm/M/sub 2/. Six additional patients were entered at this dose level and no further incidence of PN was observed.

  17. Identification of a hypoxic population of bone marrow cells

    SciTech Connect (OSTI)

    Allalunis, M.J.; Chapman, J.D.; Turner, A.R.

    1983-02-01T23:59:59.000Z

    A technique using collagenase has been devised to release and separate, with reproducibility, hematopoietic cells (HC) from various microenvironments of mouse femurs. HC were assayed by an in vitro gel culture technique used traditionally to score granulocyte-macrophage precursor cells (CFU-C). CFU-C which resided in the medullary cavity and endosteal regions were sensitive to ionizing radiation and resistant to misonidazole (MISO) cytotoxicity. CFU-C which resided within the compact bone were resistant to ionizing radiation and sensitive to the cytotoxic action of MISO. These results suggest that HC which reside in the bone are hypoxic and retain clonogenic potential. When animals were exposed to various treatments with MISO followed by myelotoxic doses of cyclophosphamide (CTX) or total body irradiation (TBI), the LD/sub 50/ of both agents was significantly reduced. This result suggests that a hypoxic component of HC could be important in the regenerative process within the marrow after such myelotoxic trauma.

  18. Combination of /sup 60/Co. gamma. -radiation, misonidazole, and maltose tetrapalmitate in the treatment of Dunning prostatic tumor in the rat

    SciTech Connect (OSTI)

    Pageau, R.; Nigam, V.N.; Fisher, G.J.; Brailovsky, C.A.; Fathi, M.A.; Corcos, J.; Tahan, T.W.; Elhilali, M.M.

    1985-08-01T23:59:59.000Z

    Maltose tetrapalmitate (MTP), a synthetic nontoxic immunoadjuvant, the radiosensitizer misonidazole (MISO), and /sup 60/Co ..gamma..-radiation, alone or in combination, were used in the management of Dunning prostatic tumor in the rat. Nine groups of 10 rats each were used to assess the efficacy of various therapeutic modalities. Tumor growth rates and animal survival times were determined for each group. Radiation was more effective when combined with MTP, but the adjuvant must be present when radiation is given for synergism to occur. MISO was as effective as MTP when used with radiation, but combining them cancels out their individual effects. In a clinical situation it would be advantageous to use separately the synergisms existing between MISO and radiation on the one hand and MTP and radiation on the other hand.

  19. Non-linear system identification in flow-induced vibration

    SciTech Connect (OSTI)

    Spanos, P.D.; Zeldin, B.A. [Rice Univ., Houston, TX (United States); Lu, R. [Hudson Engineering Corp., Houston, TX (United States)

    1996-12-31T23:59:59.000Z

    The paper introduces a method of identification of non-linear systems encountered in marine engineering applications. The non-linearity is accounted for by a combination of linear subsystems and known zero-memory non-linear transformations; an equivalent linear multi-input-single-output (MISO) system is developed for the identification problem. The unknown transfer functions of the MISO system are identified by assembling a system of linear equations in the frequency domain. This system is solved by performing the Cholesky decomposition of a related matrix. It is shown that the proposed identification method can be interpreted as a {open_quotes}Gram-Schmidt{close_quotes} type of orthogonal decomposition of the input-output quantities of the equivalent MISO system. A numerical example involving the identification of unknown parameters of flow (ocean wave) induced forces on offshore structures elucidates the applicability of the proposed method.

  20. In vivo potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by the radiation sensitizer benznidazole

    SciTech Connect (OSTI)

    Siemann, D.W.; Morrissey, S.; Wolf, K.

    1983-03-01T23:59:59.000Z

    Recent studies in mouse tumor systems have indicated a potential therapeutic advantage in combining the radiosensitizer misonidazole (MISO) with cancer chemotherapy drugs. One agent the antitumor activity of which has been enhanced to a greater extent than its hematological or gastrointestinal toxicities is the nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU). Recently, sensitizers more lipophylic than MISO have been reported to give greater tumor response enhancement when combined with CCNU. The present studies compared the potential therapeutic benefit of combining MISO (partition coefficient, 0.43) or benznidazole (BENZO) (partition coefficient, 8.5) in KHT sarcoma or RIF-1 tumor-bearing C3H mice. Both sensitizers were administered i.p. and given either 30 min before (BENZO) or simultaneously with (MISO) the chemotherapeutic agent. Survival of clonogenic tumor cells assessed 22 to 24 hr after treatment or in situ tumor growth delay were used as assays of tumor response. Normal tissue toxicity was determined using the drug dose yielding 50% animal lethality in 30 days end point. When combined with CCNU, doses of MISO (5.0 mmol/kg) or BENZO (0.3 mmol/kg) were found to yield approximately equivalent increases in both the tumor effect (enhancement ratio, approximately 1.8 to 2.0) and normal tissue toxicity (enhancement ratio approximately 1.3 to 1.4). Both sensitizers therefore led to a therapeutic benefit. However, although a approximately 10-fold lower dose of the more lipophylic sensitizer BENZO proved to be as effective as MISO at enhancing the tumoricidal effects of CCNU, this dose reduction did not result in a greater therapeutic gain for BENZO.

  1. RADIO CONTROL CRICKET V2.0

    E-Print Network [OSTI]

    5 5 4 4 3 3 2 2 1 1 D D C C B B A A PCLK PDATA PALE RADIO DATA SPI_SCK SPI_MOSI SPI_MISO CHP_SCK PCLK PDATA PALE ADC0 SPI_MISO CHP_OUT RF_DETECT AVCC AVCC VCC VCC AVCC VCC AVCC VCC VCC VCC J9 HDR 2 X AVCC AVCC AVCC AVCC RF_IN RF_OUT L1 L2 CHP_OUT R_BIAS XOSC1 XOSC2 DIO DCLK PCLK PDATA PALE RSSI C18 R13

  2. Radiosensitizing activity of 1-alkyl-3-nitropyrrolo-(2,3-b)-pyridine derivative

    SciTech Connect (OSTI)

    Jin, Y.Z.; Stratford, I.J.

    1989-02-01T23:59:59.000Z

    Radiosensitization characteristics of a newly synthesized N-(3,N'-morpholinpropyl)-2-(3-nitropyrrolo-(2,3-b)-pyridine -1-yl) ethanoic acid amide and the chemical basis of the action were studied. Partition coefficient, redox potentials for the one electron reduction of the compound were determined. This was confirmed by studies on the radiosensitization effect and cytotoxicity of the compound tested in vitro using Chinese hamster V79 cells. The results show that the sensitizing efficiency for this compound is C1.6 at a concentration of 0.5 mmol dm-3, which is similar to MISO. Its toxicity was not lower than that of MISO or metronidazole.

  3. Broad-band contemporaneous study of the Seyfert galaxy NGC 4151

    SciTech Connect (OSTI)

    Bassani, I.; Butler, R.C.; Di Cocco, G.; Della Ventura, A.; Perotti, F.

    1986-12-01T23:59:59.000Z

    The Seyfert galaxy NGC 4151 was observed on May 18, 1980 at hard X-ray/low gamma ray energies with the MISO telescope. The only excess detected was at the 3.5 sigma level in the X-ray energy range 35-105 keV. Concurrent UV, IR, optical and soft X-ray observations performed from January-May 1980 are used in conjunction with the MISO data to estimate the radiation characteristics of NGC 4151 and to define limits to models for the central powerhouse of the object, one of the most luminous in the sky. 39 references.

  4. The pharmacokinetics in mice and dogs of nitroimidazole radiosensitizers and chemosensitizers more lipophilic than misonidazole

    SciTech Connect (OSTI)

    White, R.; Workman, P.; Owen, L.

    1982-03-01T23:59:59.000Z

    The pharmacokinetic properties of nitroimidazole radiosensitizers and chemosensitizers more lipophilic than misonidazole (MISO) were examined. In dogs, 2 analogues showed comparable peak plasma concentrations with considerable shorter half-lives (t1/2) and reduced areas under curves (AUC). Benznidazole (R0 07-1051) had a much longer t1/2, a higher AUC, and somewhat higher peak concentrations. In mice tumor/plasma, brain/plasma, and tumor/brain ratios were generally similar to MISO, as was penetration of brain and peripheral nerve by benznidazole in dogs. Selection of lipophilic analogues with appropriate pharmacokinetic properties may facilitate accommodation of the potentially different requirements for improved radiosensitization or chemosensitization.

  5. Effects of radiosensitizers on intermediary metabolism in vivo

    SciTech Connect (OSTI)

    Tamulevicius, P.; Streffer, C.; Blanke, G.; Luscher, G.

    1984-08-01T23:59:59.000Z

    In the liver, MISO has little effect on glycolytic intermediates but both the lactate and G3P contents are significantly decreased shortly after administration, whereas the level of ketone-bodies is raised. The changes in hepatic metabolite levels following treatment with SR-2508 are less marked. However, in an adenocarcinoma, both the lactate and ketone-body concentrations are enhanced with MISO. The redox equilibria states are shifted not to the oxidized metabolites in the liver but instead to the reduced metabolites in tumor. These effects may have relevance for the radiotherapy in tumors.

  6. NEXT ASSEMBLY DWG. TYPE SOCORRO, NEW MEXICO 87801

    E-Print Network [OSTI]

    Groppi, Christopher

    11 12 13 14 15 16 17 18 19 20 21 22 23 24 J7 PWR IN -6.5 BIN +6.5 BIN +16.5 BIN -16.5 BIN MOSI MISO MOSI SCLK +5_A+5_A -5_A-5_A MFM- MFM+CFM+ CFM- MISO MOSI SCLK AGCV PWR MCoarseV CCoarseV MFMV CFMV DDSCS2 DDSCS3 M52+ M52- CSMONADC CSMONTEMP CSPROM WP CSAGCDAC FS EOC AGCV PWR AIN10 Master In Slave Out

  7. Correlation between medium-range order structure and glass-forming ability for Al-based metallic glasses

    SciTech Connect (OSTI)

    Wu, N. C. [College of Material and Metallurgy, Northeastern University, Shenyang 110004 (China); Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Yan, M. [Queensland Centre for Advanced Materials Processing and Manufacturing (AMPAM), School of Mechanical and Mining Engineering, The University of Queensland, Brisbane (Australia); Zuo, L. [College of Material and Metallurgy, Northeastern University, Shenyang 110004 (China); Wang, J. Q., E-mail: jqwang@imr.ac.cn [Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China)

    2014-01-28T23:59:59.000Z

    To clarify the correlation of medium-range order (MRO) structure with glass forming ability (GFA) of Al-based metallic glasses, Al{sub 86}Ni{sub 14-a}Y{sub a} (a?=?2?9 at.?%) metallic glasses were analyzed by x-ray diffraction in detail and further verified by synchrotron high-energy x-ray diffraction. The prepeak that reflects the MRO structural evolution was found to be much sensitive to alloy composition. We have proposed an icosahedral supercluster MRO structure model in Al-TM (transition metal)-RE (rare earth metal) system, which consists of 12 RE(TM)-centered clusters on the vertex of icosahedral supercluster, one RE(TM)-centered clusters in the center, and TM(RE) atoms located at RE(TM)-centered cluster tetrahedral interstices in the icosahedral supercluster. It was indicated that the MRO structural stability mainly depends on the interaction of efficient dense packing and electrochemical potential equalization principle. The Al{sub 86}Ni{sub 9}Y(La){sub 5} alloys present good GFA due to the combination of the two structural factors.

  8. None of this work has been peer-reviewed Description of ongoing Mars work led by Edwin Kite (kite@berkeley.edu), listed from most mature to least

    E-Print Network [OSTI]

    Kite, Edwin

    @berkeley.edu), listed from most mature to least mature. Overall approach is to use MRO data to divide the Early Mars atmosphere, and that most water vapor is cold-trapped as precipitation source. Thus. Snowmelt and sedimentary rocks ­ thick early atmosphere not required? The recently published MOC- NA

  9. The mechanisms of cytotoxicity and chemosensitization by misonidazole and other nitroimidazoles

    SciTech Connect (OSTI)

    Brown, J.M.

    1982-03-01T23:59:59.000Z

    This paper attempts to review and interpret the various aspects of the interaction of the electron-affinic drug misonidazole (MISO) with cells in vitro and tumors in vivo. Specifically three topics are covered: (1) The preferential toxicity of MISO to hypoxic cells; (2) The sensitization of cell in vitro in chemotherapeutic agents by hypoxic pretreatment with MISO (the preincubation effect); (3) The chemosensitization of tumors in vivo by MISO. It is concluded that hypoxic cell cytotoxicity is not a result of the binding of nitroreduction products to the cellular target molecule (or molecules), but is a result of abstraction of H atoms by neutral radicals produced during nitroreduction. However, binding does occur, and this depletes intracellular glutathione which is capable both of inactivating these toxic radicals and repairing the target lesion. The preincubation effect-at least for bifunctional alkylating agents-is postulated to be a result of a combination of depletion of intracellular glutathione (which can intercept the alkylating agent), and increase in DNA interstand cross-links. Finally, it is concluded that chemosensitization of tumors in vivo is a combination of the in vitro preincubation effect for the hypoxic cells, and an inhibition of repair of the chemotherapeutic agent damage to aerated, plateau-phase-like cells in the tumor. The former required nitroreduction, the latter does not.

  10. Keynote address: cellular reduction of nitroimidazole drugs: potential for selective chemotherapy and diagnosis of hypoxic cells

    SciTech Connect (OSTI)

    Chapman, J.D.; Lee, J.; Meeker, B.E.

    1989-04-01T23:59:59.000Z

    Nitroimidazole drugs were initially developed as selective radiosensitizers of hypoxic cells and, consequently, as adjuvants to improve the local control probabilities of current radiotherapies. Misonidazole (MISO), the prototype radiosensitizing drug, was found in Phase I clinical studies to cause dose-limiting neurotoxicities (mainly peripheral neuropathies). MISO was also found to be cytotoxic in the absence of radiation and to covalently bind to cellular molecules, both processes demonstrating rates much higher in hypoxic compared with oxygenated cells. It is likely that neurotoxicity, cellular cytotoxicity and adduct formation results from reactions between reduction intermediates of MISO and cellular target molecules. Spin-offs from radiosensitizer research include the synthesis and characterization of more potent hypoxic cytotoxins and the exploitation of sensitizer-adducts as probes for measuring cellular and tissue oxygen levels. Current developments in hypoxic cell cytotoxin and hypoxic cell marker research are reviewed with specific examples from studies which characterize the cellular reduction of TF-MISO, (1-(2-nitro-1-imidazolyl)-3(2,2,2-trifluoroethoxy)-2-propanol). 45 references.

  11. Pharmacokinetic interaction of BCNU and misonidazole in humans

    SciTech Connect (OSTI)

    Urtasum, R.C.; Tanasichuk, H.; Fulton, D.; Raleigh, J.; Rabin, H.R.; Turner, R.; Koziol, D.; Agboola, O.

    1982-03-01T23:59:59.000Z

    Although considerable laboratory in vitro and in vivo evidence is now available suggesting that misonidazole (MISO) enhances chemotherapy tumor responses, experience with human tumors is limited. Further, the mechanism of this enhancement is not defintely known. One possible mechanism is that MISO alters the pharmacokinetics of the chemotherapeutic agent, vice versa or both. We studied a group of patients with recurrent malignant gliomas, following radiotherapy. After proven recurrence, they were treated with i.v. BCNU in combination with oral MISO in an 8 week cycle. Our aims were: 1. To obtain a second remission; 2. To assess the toxicity of this combination; 3. To assess the plasma pharmacokinetics of each drug alone and in combination. Six patients entered the protocol. Four of six patients obtained either a partial or subpartial response. Prolonged moderate myelosuppression was observed in 2/6 patients after 3 cycles; 2/6 patients experienced seizures after the first cycle of chemotherapy for the first time in the course of their disease. The plasma pharmacokinetic data indicates no evidence of a MISO-BCNU drug interaction.

  12. Changes in misonidazole binding with hypoxic fraction in mouse tumors

    SciTech Connect (OSTI)

    Hirst, D.G.; Hazlehurst, J.L.; Brown, J.M.

    1985-07-01T23:59:59.000Z

    Binding of misonidazole (MISO) or a derivative to hypoxic cells in tumors has been proposed as a method for identifying tumors, and measuring their level of hypoxia. The author has recently shown that the hypoxic fraction of tumor cells can be altered over a wide range in vivo by acutely changing the hematocrit of the host animal by transfusion. The present study is aimed to investigate the changes in binding by /sup 14/C MISO that accompanied this procedure. Tumor bearing mice were injected with /sup 14/C MISO, irradiated with a single dose of X rays (20 Gy) and their tumor excised and bisected. One half of each tumor was used to determine cell survival in vitro, the other was used for /sup 14/C scintillation counting. As previously described, tumor cell survival was dramatically increased in acutely anemic mice and this was accompanied by an increase in /sup 14/C MISO binding to the tumors. The relationship between clonogenic cell survival and binding was found to be linear on a log-log plot for each of the tumor lines studied, but the slopes of the lines were different in different tumor lines and generally steeper than the value of 1.0 expected for a 1:1 correspondence between cells binding radioactivity and radiobiological resistance.

  13. Effect of nitroimidazoles on glucose utilization and lactate accumulation in mouse brain

    SciTech Connect (OSTI)

    Chao, C.F. (Roswell Park Memorial Inst., Buffalo, NY); Subjeck, J.R.; Brody, H.; Shen, J.; Johnson, R.J.R.

    1984-01-01T23:59:59.000Z

    The radiation sensitizers misonidazole (MISO) and desmethylmisonidazole (DMM) can produce central and peripheral neuropathy in patients and laboratory animals. Nitroimidazoles can also interfere with glycolysis in vitro under aerobic and anaerobic conditions. In the present work, the authors studied the effect of MISO or DMM on lactate production and glucose utilization in mouse brain. It is observed that these compounds result in a 25% inhibition of lactate production in brain slices relative to the control at a 10 mM level. Additionally, MISO (1.0 mg/g/day) or DMM (1.4 mg/g/day) were administered daily (oral) for 1, 4, 7, or 14 days to examine the effect of these two drugs on the regional glucose utilization in C3Hf mouse brain. Five microcuries of 2-deoxy(/sup 14/C)glucose was given following the last drug dose and autoradiographs of serial brain sections were made and analyzed by a densitometer. Following a single dose of either MISO or DMM, no significant differences in glucose uptake were observed when compared with controls. However, following 4, 7, and 14 doses the rate of glucose utilization was significantly reduced in the intoxicated animals. Larger reductions were measured in specific regions including the posterior colliculus, cochlear nuclei, vestibular nuclei, and pons with increasing effects observed at later stages. These results share a degree of correspondence with the regional brain pathology produced by these nitroimidazoles.

  14. Derivation of Locational Marginal Prices for Restructured Wholesale Power Markets

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    Derivation of Locational Marginal Prices for Restructured Wholesale Power Markets Haifeng Liu restructured wholesale power markets, the detailed derivation of LMPs as actually used in industry practice Operator (MISO). Keywords: Locational marginal pricing, wholesale power market, AC optimal power flow, DC

  15. Leigh Tesfatsion Professor of Econ, Math, and Electrical & Computer Engineering

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    2012 AMES Wholesale Power Market Test Bed #12;2 Presentation Outline Wholesale power market design Commission (FERC) proposed a wholesale electric power market design for common adoption throughout U.S. Over), Midwest/Manitoba (MISO), & Southwest (SPP) #12;4 FERC Wholesale Power Market Design Adopters to Date http

  16. Integrated Retail and Wholesale (IRW) Power System Operations with Smart-Grid Functionality

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    Integrated Retail and Wholesale (IRW) Power System Operations with Smart-Grid Functionality Leigh of the Integrated Retail/Wholesale (IRW) project at Iowa State University · IRW Test Bed development · Integration-NE, MISO, XM, RTE, MEC IRW Project: Integrated Retail/Wholesale Power System Operation with Smart

  17. Risk Aware Robust Decision Making in Power Systems with Renewable Resources 

    E-Print Network [OSTI]

    Thatte, Anupam Ajit

    2014-10-29T23:59:59.000Z

    Dispatch ISO Independent System Operator LMP Locational Marginal Price LORP Lack of Ramp Probability LP Linear Programming LSE Load Serving Entity MAE Mean Absolute Error MISO Midcontinent Independent System Operator MPC Model Predictive Control NERC North... . . . . . . . . . . . . . . . 30 3.2 Nordpool market timeline . . . . . . . . . . . . . . . . . . . . . . . . 38 3.3 Electricity prices for scenario A . . . . . . . . . . . . . . . . . . . . . 40 3.4 Results of deterministic optimization scenario A . . . . . . . . . . . . 40 3...

  18. MIDWEST ISO UPDATE Sherman Elliott

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    power congestion through locational marginal pricing (LMP) energy market Long term regional transmission minutes · Manage congestion via Locational Marginal Pricing (LMP), Transmission Loading Relief (TLR reserve margin #12;9 MISO Market Operations Locational Marginal Pricing (LMP) based upon Security

  19. Division of Economics and Business Working Paper Series

    E-Print Network [OSTI]

    data of wind generation and emissions from plants in ERCOT (Texas), CAISO (California), and MISO (UpperDivision of Economics and Business Working Paper Series Emissions savings from wind power generation: Evidence from Texas, California and the Upper Midwest Daniel T. Kaffine Brannin J. McBee Jozef

  20. Can Imperfect Delayed CSIT be as Useful as Perfect Delayed CSIT? DoF Analysis and

    E-Print Network [OSTI]

    Gesbert, David

    reliability, the work here considers the general problem of communicating, over the aforementioned broadcast-output (MISO) BC, where a two-antenna transmitter communicates information to two single-antenna receivers to limitations in the capacity and reliability of the feedback channel. The distinction between the quality

  1. IEEE TRANSACTIONS ON INFORMATION THEORY, VOL. 54, NO. 3, MARCH 2008 1073 A Quasi-Random Approach to SpaceTime Codes

    E-Print Network [OSTI]

    Ping, Li

    can be used to significantly increase the reliability and spectrum efficiency of wireless approach so as to ensure reliability, such as in the vertical Bell Laboratories layered space­time (V antennas. The BLAST architectures are less effective in multiple-input­single-output (MISO) environments

  2. Throughput analysis for MIMO systems in the high SNR regime Narayan Prasad and Mahesh K. Varanasi

    E-Print Network [OSTI]

    Varanasi, Mahesh K.

    . The throughputs of MISO and SIMO fading channels are extensively analyzed and it is shown that asymptoti- cally [1, 2] and is defined as the maximum rate that can be transmitted reliably over all channel realiza rate which can be reliably transmitted This work was supported in part by NSF Grant CCF-0431170

  3. Brandon Heller A number of recent advances in the physical layer are enabling wireless communications devices to reach ever-greater speeds. These

    E-Print Network [OSTI]

    Jain, Raj

    -Division Multiplexing (OFDM) 3. Multi-Antenna Techniques 3.1 Multiple Input Single Output (MISO) 3.2 Multiple Input range, better bit rates, greater battery life, and increased reliability. Upcoming standards bit-error rates. Section 4 describes options for more reliably encoding data. Section five discusses

  4. IEEE TRANSACTIONS ON COMMUNICATIONS, VOL. 58, NO. 12, DECEMBER 2010 3621 On the Diversity-Multiplexing Tradeoff of

    E-Print Network [OSTI]

    Motani, Mehul

    the multiple-input single-output (MISO) upper bound. The analysis also demonstrates that, with a careful choice signal-to-noise (SNR) regime. It is a tool to characterize the tradeoff between the reliability and the number of degrees of freedom of a communication system. Reliability is measured by diversity gain, dened

  5. Going Space Diverse Renato Lo Cigno

    E-Print Network [OSTI]

    Lo Cigno, Renato Antonio

    the diversity to increase throughput, only to improve reliability locigno@disi.unitn.it 7 #12;SISO, MISO, SIMO "explored" space diversity techniques either to improve reliability or to increase throughput (more later) n flows can be used to n Increase throughput n Increase data reliability n 802.11n allows up to 4 antennas

  6. On the Compound MIMO Broadcast Channels with Confidential Messages

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , the Gaussian MIMO-BCC and the ergodic fading multi-input single-output (MISO)-BCC without a common message. We. However, many wireless applications must guarantee secure and reliable communication in the presence the realization of the channel state. The transmitter needs to send all messages reliably while keeping each

  7. Preface page xv Acknowledgements xviii

    E-Print Network [OSTI]

    Tse, David

    -achieving AWGN channel codes 170 Summary 5.1 Reliable rate of communication and capacity 171 5.2 Resources multiple output (SIMO) channel 179 5.3.2 Multiple input single output (MISO) channel 179 5.3.3 Frequency

  8. Going Space Diverse Renato Lo Cigno

    E-Print Network [OSTI]

    Lo Cigno, Renato Antonio

    to increase throughput, only to improve reliability locigno@disi.unitn.it 7 SISO, MISO, SIMO, MIMO locigno" space diversity techniques either to improve reliability or to increase throughput (more later) n Make can be used to n Increase throughput n Increase data reliability n 802.11n allows up to 4 antennas n

  9. Diversity-Multiplexing Tradeoff in Multiple-Antenna Relay Systems

    E-Print Network [OSTI]

    Erkip, Elza

    performances. I. INTRODUCTION Fading in the wireless channel decreases communication reliability. Multiple be- tween reliability and spatial multiplexing in MIMO systems, called the diversity literature mostly focuses on diversity gains, which shows that multi-input single-output (MISO) or single

  10. Going Space Diverse Renato Lo Cigno

    E-Print Network [OSTI]

    Lo Cigno, Renato Antonio

    to increase throughput, only to improve reliability locigno@disi.unitn.it 7 #12;SISO, MISO, SIMO, MIMO locigno" space diversity techniques either to improve reliability or to increase throughput (more later) n Make flows can be used to n Increase throughput n Increase data reliability n 802.11n allows up to 4 antennas

  11. The effect of short-term soy isoflavone supplementation on mRNA in localized prostate cancer

    E-Print Network [OSTI]

    Rubin, Jessica D.

    2013-08-31T23:59:59.000Z

    matters as the reliability of data can be compromised by the source (e.g. cell lines or human tissue) and quality of mRNA (17,18). Although “omics” research continues to... steamed, roasted, or processed into different soy-­?based products, ranging from more traditional soy foods (e.g. tofu, miso, tempeh, and soy milk) to “second generation” soy...

  12. A Reliable method for Blind Channel Identification using Burst Data

    E-Print Network [OSTI]

    Raphaeli, Dan

    1 A Reliable method for Blind Channel Identification using Burst Data Dan Raphaeli, Senior Member Output (MISO) FIR channels with nonminimum phase. The approach is based on mini- mizing a cost function of identification success when consider- ing statistical channels, its ability to obtain reliable channel estimates

  13. Outage Efficient Strategies for Network MIMO with Partial CSIT

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ) beamforming in a distributed manner, which creates K parallel MISO channels. Based on the statistical reliability to individual users. I. INTRODUCTION Recently, network MIMO (where neighboring BSs are con- nected of a multi-cell downlink system for B = K = 3 and M = 3. Assuming a reliable (possibly wired) backbone link

  14. IEEE COMMUNICATIONS LETTERS, VOL. 16, NO. 12, DECEMBER 2012 1913 A Reduced Overhead OFDM Relay System with

    E-Print Network [OSTI]

    Minn, Hlaing

    [8]­[12]. For multiple-input single- output (MISO) systems, TMRC-BF is an effective diversity scheme com- bines the channel gains and enhances transmission reliability. However, relay clustering combined system. TMRC-BF is used at the relays in order to improve reliability while relay clustering is employed

  15. IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, VOL. , NO. , 2008 1 MIMO-OFDMA Measurements; Reception, Testing,

    E-Print Network [OSTI]

    Arslan, Hüseyin

    of descriptive instructions to conduct reliable measurements. Second, the in- creased hardware cost due of single input multiple output (SIMO) and MISO systems as a result of operating on a number of parallel are considered suitable candidates for 4G [6], [7]. Reliable MIMO implementation in WiMAX systems as well

  16. 2013 UEC Tokyo. Real-time Mobile Food

    E-Print Network [OSTI]

    Yanai, Keiji

    . miso soup 3. Egg sunny-side up 4. Sirloin cutlet 5. Salmom meuniere 6. Fried fish 7. Boiled fish 8 · Real-time image recognition · Estimation of the more reliable direction 3 key features of the system the result ­ The window with the maximum score Estimation of the more reliable direction 1 result #12; 2013

  17. Decentralized Charging Control for Large Populations of Plug-in Electric Vehicles

    E-Print Network [OSTI]

    Hiskens, Ian A.

    aggregate non-PEV base demand for the region managed by the Midwest Independent System Operator (MISO are rational and weakly coupled via their operation costs. At an established Nash equilibrium, each of the PEV establishes a sufficient condition under which the system converges to the unique Nash equilibrium

  18. Transmission Design at the National Level: Benefits, Risks and Possible Paths Forward

    E-Print Network [OSTI]

    Independent Transmission System Operator (MISO) #12;ii Executive Summary Today all areas of the contiguous U Initiative White Paper Power Systems Engineering Research Center Empowering Minds to Engineer the Future Electric Energy System #12;Transmission Design at the National Level: Benefits, Risks and Possible Paths

  19. On multiple-antenna communications: signal detection, error exponent and and quality of service

    E-Print Network [OSTI]

    Li, Qiang

    2009-05-15T23:59:59.000Z

    . . . . . . . . . . . . . . . . . . . . . . . . . . . 90 VII QUALITY-OF-SERVICE FOR A BUFFERED TRANSMIS- SION OVER FADING CHANNEL . . . . . . . . . . . . . . . . 93 A. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . 93 B. Problem Statement . . . . . . . . . . . . . . . . . . . . . . 96 C...) . . . . . . . . . . . . . 106 a. Asymptotic Analysis . . . . . . . . . . . . . . . . 106 b. Example . . . . . . . . . . . . . . . . . . . . . . . 107 2. SIMO/MISO Antennas System . . . . . . . . . . . . . 111 E. Distortion Exponent of MIMO Block Fading Channel . . . 112 1. MIMO...

  20. On multiple-antenna communications: signal detection, error exponent and and quality of service

    E-Print Network [OSTI]

    Li, Qiang

    2008-10-10T23:59:59.000Z

    . . . . . . . . . . . . . . . . . . . . . . . . . . . 90 VII QUALITY-OF-SERVICE FOR A BUFFERED TRANSMIS- SION OVER FADING CHANNEL . . . . . . . . . . . . . . . . 93 A. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . 93 B. Problem Statement . . . . . . . . . . . . . . . . . . . . . . 96 C...) . . . . . . . . . . . . . 106 a. Asymptotic Analysis . . . . . . . . . . . . . . . . 106 b. Example . . . . . . . . . . . . . . . . . . . . . . . 107 2. SIMO/MISO Antennas System . . . . . . . . . . . . . 111 E. Distortion Exponent of MIMO Block Fading Channel . . . 112 1. MIMO...

  1. Growth control of the eukaryote cell: A systems biology study in yeast

    E-Print Network [OSTI]

    Castrillo, Juan I; Zeef, Leo A; Hoyle, David C; Zhang, Nianshu; Hayes, Andrew; Gardner, David C J; Cornell, Michael J; Petty, June; Hakes, Luke; Wardleworth, Leanne; Rash, Bharat; Brown, Marie; Dunn, Warwick B; Broadhurst, David; O'Donoghue, Kerry; Hester, Svenja S; Dunkley, Tom P J; Hart, Sarah; Swainston, Neil; Li, Peter; Gaskell, Simon J; Paton, Norman W; Lilley, Kathryn S; Kell, Douglas B; Oliver, Stephen G

    2007-04-30T23:59:59.000Z

    -line. At appropriate intervals, culture samples were collected for determination of biomass concentration. Biomass levels were monitored both spectrophotometrically at a wavelength of 600 nm, and by dry weight. Dry weight measurements were determined as described... , corresponding to the biological process: tRNA aminoacylation for protein translation (GO tool: GenMAPP). Colour code as in Fig. S17. Fig. S20. Storage vacuole. Groups of genes significantly up-regulated and down-regulated corresponding to the cellular...

  2. Geometria Differenziale. a.a. 2007-08. Prof. P. Piazza

    E-Print Network [OSTI]

    Piazza, Paolo

    delle funzioni v = ±r sin u, u [0, 2] Calcolare l'area della regione R := (Q) e verificare che Area parametrizzazione (u, v) (u, v, uv) e base di arrivo la base canonica di R. Determinare il vettore tangente wP TP) Utilizzare (i) e (ii) per determinare le due mappe OW Hom(V0, W) , OW Hom(V0, W) una inversa dell

  3. The Murchison Widefield Array Correlator

    E-Print Network [OSTI]

    Ord, S M; Emrich, D; Pallot, D; Wayth, R B; Clark, M A; Tremblay, S E; Arcus, W; Barnes, D; Bell, M; Bernardi, G; Bhat, N D R; Bowman, J D; Briggs, F; Bunton, J D; Cappallo, R J; Corey, B E; Deshpande, A A; deSouza, L; Ewell-Wice, A; Feng, L; Goeke, R; Greenhill, L J; Hazelton, B J; Herne, D; Hewitt, J N; Hindson, L; Hurley-Walker, H; Jacobs, D; Johnston-Hollitt, M; Kaplan, D L; Kasper, J C; Kincaid, B B; Koenig, R; Kratzenberg, E; Kudryavtseva, N; Lenc, E; Lonsdale, C J; Lynch, M J; McKinley, B; McWhirter, S R; Mitchell, D A; Morales, M F; Morgan, E; Oberoi, D; Offringa, A; Pathikulangara, J; Pindor, B; Prabu, T; Procopio, P; Remillard, R A; Riding, J; Rogers, A E E; Roshi, A; Salah, J E; Sault, R J; Shankar, N Udaya; Srivani, K S; Stevens, J; Subrahmanyan, R; Tingay, S J; Waterson, M; Webster, R L; Whitney, A R; Williams, A; Williams, C L; Wyithe, J S B

    2015-01-01T23:59:59.000Z

    The Murchison Widefield Array (MWA) is a Square Kilometre Array (SKA) Precursor. The telescope is located at the Murchison Radio--astronomy Observatory (MRO) in Western Australia (WA). The MWA consists of 4096 dipoles arranged into 128 dual polarisation aperture arrays forming a connected element interferometer that cross-correlates signals from all 256 inputs. A hybrid approach to the correlation task is employed, with some processing stages being performed by bespoke hardware, based on Field Programmable Gate Arrays (FPGAs), and others by Graphics Processing Units (GPUs) housed in general purpose rack mounted servers. The correlation capability required is approximately 8 TFLOPS (Tera FLoating point Operations Per Second). The MWA has commenced operations and the correlator is generating 8.3 TB/day of correlation products, that are subsequently transferred 700 km from the MRO to Perth (WA) in real-time for storage and offline processing. In this paper we outline the correlator design, signal path, and proce...

  4. Correlation of atomic packing with the boson peak in amorphous alloys

    SciTech Connect (OSTI)

    Yang, W. M. [State Key Laboratory for Geomechanics and Deep Underground Engineering, School of Mechanics and Civil Engineering, School of Sciences, China University of Mining and Technology, Xuzhou 221116 (China); Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201 (China); School of Materials Science and Engineering, Southeast University, Nanjing 211189 (China); Liu, H. S., E-mail: liuhaishun@126.com, E-mail: blshen@seu.edu.cn, E-mail: runweili@nimte.ac.cn, E-mail: jiangjz@zju.edu.cn; Zhao, Y. C. [State Key Laboratory for Geomechanics and Deep Underground Engineering, School of Mechanics and Civil Engineering, School of Sciences, China University of Mining and Technology, Xuzhou 221116 (China); Liu, X. J. [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Chen, G. X.; Man, Q. K.; Chang, C. T.; Li, R. W., E-mail: liuhaishun@126.com, E-mail: blshen@seu.edu.cn, E-mail: runweili@nimte.ac.cn, E-mail: jiangjz@zju.edu.cn [Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201 (China); Dun, C. C. [Department of Physics, Wake Forest University, Winston-Salem, North Carolina 27109 (United States); Shen, B. L., E-mail: liuhaishun@126.com, E-mail: blshen@seu.edu.cn, E-mail: runweili@nimte.ac.cn, E-mail: jiangjz@zju.edu.cn [School of Materials Science and Engineering, Southeast University, Nanjing 211189 (China); Inoue, A. [Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201 (China); WPI Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577 (Japan); and others

    2014-09-28T23:59:59.000Z

    Boson peaks (BP) have been observed from phonon specific heats in 10 studied amorphous alloys. Two Einstein-type vibration modes were proposed in this work and all data can be fitted well. By measuring and analyzing local atomic structures of studied amorphous alloys and 56 reported amorphous alloys, it is found that (a) the BP originates from local harmonic vibration modes associated with the lengths of short-range order (SRO) and medium-range order (MRO) in amorphous alloys, and (b) the atomic packing in amorphous alloys follows a universal scaling law, i.e., the ratios of SRO and MRO lengths to solvent atomic diameter are 3 and 7, respectively, which exact match with length ratios of BP vibration frequencies to Debye frequency for the studied amorphous alloys. This finding provides a new perspective for atomic packing in amorphous materials, and has significant implications for quantitative description of the local atomic orders and understanding the structure-property relationship.

  5. Nitroimidazoles as modifiers of nitrosourea pharmacokinetics

    SciTech Connect (OSTI)

    Lee, F.Y.F.; Workman, P.

    1984-09-01T23:59:59.000Z

    The effect of a number of nitroimidazole sensitizers of varying lipophilicity has been studied on the pharmacokinetics of CCNU in mice. It was found that the effectiveness of these compounds in producing pharmacokinetic effects correlated directly with their lipophilicity. The effects of MISO on the pharmacokinetics of 4 nitrosoureas of differing lipophilicity were also investigated. The plasma clearances of CCNU, BCNU and MeCCNU (high lipophilicity) were slowed by MISO whereas that of chlorozotocin (Chlz) (low lipophilicity) was unaffected. Thus, it seems that for a pharmacokinetic interaction to occur between a nitroimidazole and a nitrosourea, both the modifier and the cytotoxic agent must have a requisite degree of lipophilicity. As the same requirement appears to hold for enhancement of tumor response, these data provide further evidence that pharmacokinetic modification plays a major role in chemosensitization.

  6. Lethal or protective effects of prolonged treatment with hypoxic cell sensitizers

    SciTech Connect (OSTI)

    Edgren, M.R. [Karolinska Inst., Stockholm (Sweden). Dept. of Medical Radiation Physics

    1995-12-31T23:59:59.000Z

    AK-2123 [N-(2-methoxyethyl)-2-(3-nitro-1-triazolyl)acetamide] is a hypoxic cell radiosensitizer which is currently being tested in several oncology clinics and which has a lower toxicity than misonidazole (MISO) in vivo. The positive experiences reported recently certainly warrant further clinical evaluations. The experimental observations reported so far need further experimental studies to clarify the sensitization mechanism, especially as recent intratumoral strategies used in the clinical administration of the sensitizers can result in a large local concentration of the drug that may persist for a prolonged period of time between and after radiation exposures. Model experiments in vitro using V79 cells were performed with AK-2123 under these conditions. Misonidazole (MISO) and metronidazole (METRO), well known hypoxic cell radiosensitizers, were used for comparison of the effects. Clonogenic survival and induction and repair of DNA damage were used as end-points.

  7. Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers

    SciTech Connect (OSTI)

    Stratford, I.J.

    1982-03-01T23:59:59.000Z

    Some of the mechanisms by which drugs can potentiate the radiation response of tumors and cells in culture are discussed. Emphasis is placed on the action of nitroaromatic and heterocyclic compounds as hypoxic cell radiosensitizers, and some potential successors to misonidazole (MISO) are described. These include desmethylmisonidazole and SR 2508, selected because of their low toxicity in experimental systems. Groups of compounds, more efficient sensitizers than would be predicted from electron affinity correlations, have been examined and the use of Ro-03-8799 or RSU 1047 is proposed. Finally, ortho-substituted nitroimidazoles and electron-affinic compounds with alkylating groups are described. The latter group, in particular, holds promise for the development of compounds much superior to MISO.

  8. SR-2508 plus buthionine sulfoximine or SR-2508 alone: effects on the radiation response and the glutathione content of a human tumor xenograft

    SciTech Connect (OSTI)

    Lespinasse, F.; Biscay, P.; Malaise, E.P.; Guichard, M.

    1987-04-01T23:59:59.000Z

    This study determined the radiosensitivity of the human tumor xenograft HT29 and its glutathione (GSH) and cysteine (CYS) contents after treatment with both buthionine sulfoximine (BSO) and SR-2508 or SR-2508 alone. Tumor radiosensitivity was assessed by the in vitro colony assay and thiol content was measured by high-performance liquid chromatography. The radiosensitizing effect of SR-2508 is dose dependent and increases when higher doses of radiation are given. SR-2508 given alone does not modify GSH and CYS content; however, when given with BSO, the GSH level is significantly reduced, yet radiosensitivity of the HT29 tumor is only slightly increased. These results have been compared to our previously observed results of HT29 treatment with misonidazole (MISO), BSO, or MISO + BSO.

  9. Radiation dose fractionation studies with hypoxic cell radiosensitizers using a murine tumor. [X-ray; mice

    SciTech Connect (OSTI)

    Hill, R.P.

    1982-03-01T23:59:59.000Z

    The ability of five nitroimidazoles, metronidazole (MET), misonidazole (MISO), desmethymisonidazole (DMM), SR 2508 and SR 2555, to sensitize the KHT sarcoma to radiation treatment has been compared for drug doses in the range 0-1.5 g/Kg. Single radiation doses or two different daily fractionation schedules (4 fractions of 5 Gy each or 7 fraction of 3 Gy each) were used; the tumor cell survival was determined using either an in vivo or in vitro colony assay. Each radiation (100 kVp X rays at 11 Gy/min) treatment was given locally, 60-70 min (MET) or 30-40 min (other drugs) after either intraperitoneal (MET, MISO, DMM) or intraveous (SR 2508, SR 2555) injection of the drugs; these times have been shown to be optimum for this tumor. For the single doses and both fractionation schedules the tumor cell survival, following the irradiation treatment, declined as the drug dose increased in the range 0 to 0.75 g/Kg for all the drugs, but above this dose level a plateau was reached and the amount of sensitization remained essentially constant. In this plateau region the reduction in survival achieved was similar for single doses and 5 Gy fraction but was less for 3 Gy fractions, indicating that sensitization was smaller for the smaller dose fractions. For the 4 x 5 Gy fractionation schedule the plateau level of survival was lowest for MISO, DMM and SR 2508, slightly higher for SR 2555 and much higher for MET. For the 3 Gy fractions SR 2508 appeared slightly less effective than MISO and DMM.

  10. Clinical perspectives for the use of new hypoxic cell sensitizers

    SciTech Connect (OSTI)

    Brown, J.M.

    1982-09-01T23:59:59.000Z

    Experience with high pressure oxygen in combination with radiotherapy has shown that, for some tumors at least, the presence of hypoxic cells is a limiting factor in the ability to cure these tumors even with conventional daily fractionation. This suggests that hypoxic cell radiosensitizers, of which misonidazole (MISO) is the prototype drug, may play a role in improving the cure-rate of some tumors when combined with daily fractionation. Even for those tumors for which no improvement is seen when combined with daily fractionation, it is likely that there will be an important role for these sensitizers by using them in combination with regimens of only a few dose fractions. Because of the limiting side effects of neuropathy, a less toxic radiosensitizer than MISO is required to gain the full clinical benefit of these drugs. A possible way of achieving this is to reduce the lipid solubility (lipophilicity) of the compounds while still retaining their electron-affinity. This reduces the concentration of drug in the neural tissues (brain, peripheral nerves) without affecting the tumor concentration. However, if the lipophilicity is too low, the drugs are unable to enter the hypoxic cells and hence lose their radiosensitivity efficiency. It would appear that a lipophilicity given by an octanol:water partition coefficient of approximately 0.04 is optimum (cf. MISO = 0.43) with the 2-nitroimidazole amide SR-2508 the best in this series. Tumor levels of this drug of at least 7-8 times those obtained with MISO should be attainable clinically for no increase in neurotoxicity. Another property of electron-affinic sensitizers shows clinical promise. This is their ability to preferentially sensitize tumors compared to normal tissues to the cytotoxic action of several chemotherapeutic agents.

  11. Radiosensitizing effect of misonidazole in combination with an inhibitor of glutathione synthesis in murine tumors

    SciTech Connect (OSTI)

    Ono, K.; Komuro, C.; Nishidai, T.; Shibamoto, Y.; Tsutsui, K.; Takahashi, M.; Abe, M.

    1986-09-01T23:59:59.000Z

    The radiosensitizing effects of misonidazole (MISO) in combination with D,L-buthionine-S, R-sulfoximine (BSO), an inhibitor of glutathione (GSH) biosynthesis, were studied in NFSa tumors of C/sub 3/H/He mice. The radiation response of tumors was assayed by the tumor growth delay time. The GSH contents in tissues were assayed by high performance liquid chromatography (HPLC). GSH content in the tumors decreased to the minimum level (45% of the control), and then gradually recovered to 75% of the control, respectively, 12 and 24 hr after the intraperitoneal injection of 5 mmole/kg BSO. On the other hand, the maximum non-protein sulfhydryl (NPSH) depletion (29% of the control) in the liver of tumor bearing mice was achieved 6 hr after the administration of the same dose of BSO, but fully recovered 24 hr later. When 5 mmole/kg BSO was injected repeatedly 4 times at an interval of 6 hr, GSH content in the tumors decreased to 19% of the control 24 hr after the first injection of BSO. The radiosensitizing effect of 0.5 mmole/kg MISO was markedly increased by this BSO treatment. The enhancement ratio (ER) of this combined treatment was 1.93. On the other hand, ERs of 1.44 and 1.16 were obtained for MISO (0.5 mmole/kg) and for 4 injections of BSO (5 mmole/kg) in combination with radiation, respectively. Although a considerable increase in the radiosensitizing efficiency of MISO in vivo by the treatment with BSO was found without any notable side effects of the combination, more studies on toxicities are needed to get a definite conclusion on the clinical applicability of the combination.

  12. Effect of tumor size on S-2-(3-aminopropylamino)ethylphosphorothioic acid and misonidazole alteration of tumor response to cyclophosphamide

    SciTech Connect (OSTI)

    Milas, L.; Ito, H.; Hunter, N.

    1983-07-01T23:59:59.000Z

    The influence of tumor size on the ability of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) or misonidazole (MISO) to alter cyclophosphamide (CY) antitumor activity was investigated, using a chemically induced fibrosarcoma (FSA) and a spontaneous fibrosarcoma (NFSA) in C3Hf/Kam mice. Tumors were of two sizes at the time of treatment, 8-mm leg tumors and 4-day-old micrometastases in the lung. The antitumor activity of CY and its modification were assessed by growth delay of leg tumors and the reduction in the number of lung metastases. Both measures of tumor response were more pronounced as the dose of CY increased, and FSA was more sensitive to CY than was NFSA. WR-2721 (400 mg/kg), given 30 min before treatment with CY, reduced the effectiveness of CY on both FSA and NFSA. This reduction in effectiveness of CY was only minimal for leg tumors (dose-modifying factors were 1.1 for FSA and 1.03 for NFSA) but remarkable for lung micrometastases (dose-modifying factors were 1.81 for FSA and 1.55 for NFSA). Protection increased with the increase in the dose of WR-2721 and was also dependent on the time of injection relative to CY. The greatest protection occurred when WR-2721 was given within 30 min before to 15 min after CY. Tumor size had the opposite effect on MISO from that on WR-2721. MISO (1 mg/g) enhanced the effect of CY more effectively for leg tumors than for lung micrometastases: dose-modifying factors were 1.74 for FSA and 2.21 for NFSA growing in the leg and 1.27 for FSA and 1.11 for NFSA lung micrometastases. Therefore, tumor size appears to be a very important factor in determining the extent of WR-2721- and MISO-induced modification of CY antitumor effect.

  13. Recovery of signals measured by inaccurate sensors

    E-Print Network [OSTI]

    Xiao, Lijin

    2001-01-01T23:59:59.000Z

    . [26] F. Natterer, "EAicient evaluation of oversampled functions, " Journal of Computation and Applied Mathematics, vol. 14, pp. 303-309, 1986. 51 [27] L. Rutkowski, "Identification of MISO nonlinear regression in the presence of a wide class.... Lindner, G. A. Zvonar, W. T. Baumann and P. L. Delos, "Nonlinearity effects of a model domain optical fiber sensor in a vibration suppression control loop for a flexible structure, " Journal of Vibration, Acoustics, Stress, and Reliability in Design...

  14. Joint source channel coding for non-ergodic channels: the distortion signal-to-noise ratio (SNR) exponent perspective

    E-Print Network [OSTI]

    Bhattad, Kapil

    2008-10-10T23:59:59.000Z

    . . . . . . . . . . . . . . . . . . . . . . . 72 F. Performance Analysis . . . . . . . . . . . . . . . . . . . . . 73 1. SISO / SIMO / MISO . . . . . . . . . . . . . . . . . . 77 2. The General MIMO Channel . . . . . . . . . . . . . . 79 3. Block Fading SISO Channel / Parallel SISO Channels 86 4... the mutual information between U and V. The second part, channel coding, is to send the bit stream B reliably over the channel. This is possible if and only if the channel coding rate Rc (bits per channel use) is less than the capacity of the channel...

  15. Iodoazomycin riboside (1-(5'-iodo-5'-deoxyribofuranosyl)-2-nitroimidazole), a hypoxic cell marker. I. Synthesis and in vitro characterization

    SciTech Connect (OSTI)

    Jette, D.C.; Wiebe, L.I.; Flanagan, R.J.; Lee, J.; Chapman, J.D.

    1986-02-01T23:59:59.000Z

    Misonidazole (MISO), a selective radiosensitizer of hypoxic cells, forms adducts with cellular biomolecules with rates which are 30-50 X higher under hypoxic as compared to aerobic conditions of incubation. This technique of sensitizer adduct formation was proposed as a possible means of measuring the hypoxic fraction of solid tumors by noninvasive procedures. Iodoazomycin riboside (5'-IAZR) and 5'-(125I)AZR were synthesized and chemically characterized. Measurements of in vitro cytotoxicity and radiosensitizing ability with EMT-6 tumor cells in vitro indicated that 5'-IAZR is approximately 3 X more toxic and effective than is azomycin riboside (AZR) and approximately 10 X more toxic and effective than is MISO. 5'-(125I)AZR was shown to selectively bind to hypoxic EMT-6 cells at rates which were 2.5-3 X faster than those of MISO. The absolute rates of binding of 5'-IAZR to hypoxic cells at concentrations of 10-100 microM are the highest observed in this laboratory for any hypoxic cell radiosensitizer tested to date. These data suggest that 5'-IAZR, when labeled with an appropriate radioisotope (e.g., 131I), might be a useful marker for hypoxic cells in solid tumors amenable to noninvasive detection. Additional studies with animal tumor models appear to be warranted.

  16. Is Misonidazole neurotoxicity altered by the use of phenytoin and/or dexamethasone in RTOG 79-18 and RTOG 79-16

    SciTech Connect (OSTI)

    Nelson, D.F.; Gillespie, B.W.; Diener, M.D.; Davis, D.R.; Wasserman, T.; Phillips, T.L.; Stetz, J.

    1984-09-01T23:59:59.000Z

    An analysis of Misonidazole (MISO) neurotoxicity in RTOG 79-16 and RTOG 79-18 was undertaken to evaluate the incidence of neurotoxicity relative to dexamethasone dose and phenytoin use. Practically all patients were on dexamethasone, and 240 out of 550 were on phenytoin for seizures. CNS toxicity and ototoxicity rates were no different between treatment groups with overall rates of 2.7 and 1.1%, respectively. Phenytoin did not significantly alter CNS and peripheral neuropathy (PN) toxicity rates. All ototoxicities occurred in patients not on phenytoin. There was no correlation between dexamethasone dose and incidence of neurotoxicity within each study. However, the incidence of (PN) for the combined studies was 6.4% (35/550) which is lower than 18.9% (85/449) for non-brain Phase III protocols where patients are rarely, if ever, on dexamethasone or other corticosteroids. Four hour and 24 hour plasma MISO levels, and 24 hour/4 hour MISO ratios did not correlate with toxicity.

  17. Radiosensitization by a new nucleoside analogue: 1-(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl-2-nitroimidazole (RP-170)

    SciTech Connect (OSTI)

    Murayama, C.; Suzuki, A.; Suzuki, T.; Miyata, Y.; Sakaguchi, M.; Tanabe, Y.; Tanaka, N.; Mori, T. (Tokai Univ. (Japan))

    1989-09-01T23:59:59.000Z

    A new potent hypoxic cell sensitizer, a 2-nitroimidazole nucleoside analogue having methoxyglycerol as a sugar moiety at the N-1 position of the imidazole ring (RP-170), has been synthesized. Its radiosensitizing activities in vitro and in vivo were investigated and compared with those of misonidazole (MISO) and etanidazole (SR-2508). As might be expected from the almost identical electron affinities of the three compounds, they were equally effective against hypoxic EMT6 cells in vitro. The in vivo-in vitro excision analysis showed that RP-170 was also as effective as MISO and etanidazole to radiosensitize solid tumor cells in vivo. An intraperitoneal administration of 200 mg/kg of RP-170 and an intravenous administration of the same dose of etanidazole showed an equal sensitizer-enhancement ratio of 1.51 to solid EMT6/KU tumors. Its effectiveness was also demonstrated by growth delay assay using solid SCCVII tumors. As predicted from the low partition coefficient, RP-170 and etanidazole showed apparently lower toxicity in vivo than MISO; their LD50/14 were 4.3, 4.8, and 1.8 g/kg in our experiment, respectively. Moreover, RP-170 showed fast clearance from serum in mice (t1/2 = 10.24 min) and poor penetration into neural tissues. Although RP-170 does not show any advantages over etanidazole in terms of sensitization or toxicity, RP-170 might be preferable under certain circumstances because it can be given orally.

  18. In vitro and in vivo radiosensitization by 2-nitroimidazoles more electron-affinic than misonidazole

    SciTech Connect (OSTI)

    Brown, D.M. (Stanford Univ., CA); Yu, N.Y.; Brown, J.M.; Lee, W.W.

    1982-03-01T23:59:59.000Z

    A series of 5-substituted-methyl-2 nitroimidazoles, more electron-affinic than misonidazole (MISO), has been studied as potential hypoxic cell radiosensitizers. In vitro radiosensitization studies of these compounds showed equivalent or greater radiosensitization than MISO, while LD/sub 50/ studies of the compounds found them to be, in general, more toxic to Balb/c mice than MISO. Radiosensitization experiments in vivo with compounds SR-2537, SR-2515 and SR-2553 of acceptable toxicity were not able to sensitize the EMT6 tumor to x-irradiation after a single intraperitoneal injection. However, moderate sensitization was achieved when SR-2537 was administered i.v. Rapid metabolism of these more electron-affinic compounds was suggested as a possible case of the poor sensitization. However, when multiple i.v. injections of SR-2537 were given to maintain a constant drug level in the tumor, radiosensitization by this compound did not improve, suggesting that intact drug was either not reaching or was not penetrating the hypoxic cells.

  19. Liquid Lithium Divertor and Scrape-Off-Layer Interactions on the National Spherical Torus Experiment: 2010 ? 2013 Progress Report

    SciTech Connect (OSTI)

    None

    2013-08-27T23:59:59.000Z

    The implementation of the liquid Lithium Divertor (LLD) in NSTX presented a unique opportunity in plasma-material interactions studies. A high density Langmuir Probe (HDLP) array utilizing a dense pack of triple Langmuir probes was built at PPPL and the electronics designed and built by UIUC. It was shown that the HDLP array could be used to characterize the modification of the EEDF during lithium experiments on NSTX as well as characterize the transient particle loads during lithium experiments as a means to study ELMs. With NSTX being upgraded and a new divertor being installed, the HDLP array will not be used in NSTX-U. However UIUC is currently helping to develop two new systems for depositing lithium into NSTX-U, a Liquid Lithium Pellet Dripper (LLPD) for use with the granular injector for ELM mitigation and control studies as well as an Upward-Facing Lithium Evaporator (U-LITER) based on a flash evaporation system using an electron beam. Currently UIUC has Daniel Andruczyk Stationed at PPPL and is developing these systems as well as being involved in preparing the Materials Analysis Particle Probe (MAPP) for use in LTX and NSTX-U. To date the MAPP preparations have been completed. New sample holders were designed by UIUC?s Research Engineer at PPPL and manufactured at PPPL and installed. MAPP is currently being used on LTX to do calibration and initial studies. The LLPD has demonstrated that it can produce pellets. There is still some adjustments needed to control the frequency and particle size. Equipment for the U-LITER has arrived and initial test are being made of the electron beam and design of the U-LITER in progress. It is expected to have these ready for the first run campaign of NSTX-U.

  20. The Annotated Mina, Volume One

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    .G. Wodehouse books. Alert Harkers have also seen a resemblance to E. F. Benson’s Lucia and Mapp; this was unintentional on my part. 4 There have been many instances within fandom of well-known fans attempting to persuade or encourage their ‘friends...’ to send them money or buy them gifts. Examples include Cousin Jean asking for money to take a year off and write fanfiction, and efforts to buy Cassie Clare (the former Cassie Claire) an iPod. Embitca. ‘Can’t We Just Buy You an iPod?’ Fandom Wank 10...

  1. Coordination of Retail Demand Response with Midwest ISO Markets

    SciTech Connect (OSTI)

    Bharvirkar, Ranjit; Bharvirkar, Ranjit; Goldman, Charles; Heffner, Grayson; Sedano, Richard

    2008-05-27T23:59:59.000Z

    The Organization of Midwest ISO States (OMS) launched the Midwest Demand Resource Initiative (MWDRI) in 2007 to identify barriers to deploying demand response (DR) resources in the Midwest Independent System Operator (MISO) region and develop policies to overcome them. The MWDRI stakeholders decided that a useful initial activity would be to develop more detailed information on existing retail DR programs and dynamic pricing tariffs, program rules, and utility operating practices. This additional detail could then be used to assess any"seams issues" affecting coordination and integration of retail DR resources with MISO's wholesale markets. Working with state regulatory agencies, we conducted a detailed survey of existing DR programs, dynamic pricing tariffs, and their features in MISO states. Utilities were asked to provide information on advance notice requirements to customers, operational triggers used to call events (e.g. system emergencies, market conditions, local emergencies), use of these DR resources to meet planning reserves requirements, DR resource availability (e.g., seasonal, annual), participant incentive structures, and monitoring and verification (M&V) protocols. This report describes the results of this comprehensive survey and discusses policy implications for integrating legacy retail DR programs and dynamic pricing tariffs into organized wholesale markets. Survey responses from 37 MISO members and 4 non-members provided information on 141 DR programs and dynamic pricing tariffs with a peak load reduction potential of 4,727 MW of retail DR resource. Major findings of this study area:- About 72percent of available DR is from interruptible rate tariffs offered to large commercial and industrial customers, while direct load control (DLC) programs account for ~;;18percent. Almost 90percent of the DR resources included in this survey are provided by investor-owned utilities. - Approximately, 90percent of the DR resources are available with less than two hours advance notice and over 1,900 MW can be dispatched on less than thirty minutes notice. These legacy DR programs are increasingly used by utilities for economic in addition to reliability purposes, with over two-thirds (68percent) of these programs callable based on market conditions. - Approximately 60percent of DLC programs and 30percent of interruptible rate programs called ten or more DR events in 2006. Despite the high frequency of DR events, customer complaints remained low. The use of economic criteria to trigger DR events and the flexibility to trigger a large number of events suggests that DR resources can help improve the efficiency of MISO wholesale markets. - Most legacy DR programs offered a reservation payment ($/kW) for participation; incentive payment levels averaged about $5/kW-month for interruptible rate tariffs and $6/kW-month for DLC programs. Few programs offered incentive payments that were explicitly linked to actual load reductions during events and at least 27 DR programs do not have penalties for non-performance. - Measurement and verification (M&V) protocols to estimate load impacts vary significantly across MISO states. Almost half of the DR programs have not been evaluated in recent times and thus performance data for DR events is not available. For many DLC programs, M&V protocols may need to be enhancedin order to allow participation in MISO's proposed EDR schedule. System operators and planners will need to develop more accurate estimates of the load reduced capability and actual performance.

  2. Plant maintenance and outage management issue, 2005

    SciTech Connect (OSTI)

    Agnihotri, Newal (ed.)

    2005-01-15T23:59:59.000Z

    The focus of the January-February issue is on plant maintenance and outage managment. Major articles/reports in this issue include: Dawn of a new era, by Joe Colvin, Nuclear Energy Institute (NEI); Plant profile: Beloyarsk NPP, Russia, by Nikolai Oshkanov, Beloyarsk NPP, Russia; Improving economic performance, by R. Spiegelberg-Planner, John De Mella, and Marius Condu, IAEA; A model for improving performance, by Pet Karns, MRO Software; ASME codes and standards, by Shannon Burke, ASME International; and, Refurbishment programs, by Craig S. Irish, Nuclear Logistics, Inc.

  3. Summary o

    Office of Legacy Management (LM)

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  4. Summary of Weldon Spring Site Focus Area

    Office of Legacy Management (LM)

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  5. Surface Corrective Action Investigation Report for the Gnome-Coach Site, New Mexico

    Office of Legacy Management (LM)

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  6. T

    Office of Legacy Management (LM)

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  7. T

    Office of Legacy Management (LM)

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  8. T

    Office of Legacy Management (LM)

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  9. T

    Office of Legacy Management (LM)

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  10. T D

    Office of Legacy Management (LM)

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  11. T H E A E R O S P A C E C O R P O R A T I O N

    Office of Legacy Management (LM)

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  12. TABLE OF CONTENTS

    Office of Legacy Management (LM)

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  13. THE AEROSPACE CORPORATION

    Office of Legacy Management (LM)

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  14. THE AEROSPACE CORPORATION

    Office of Legacy Management (LM)

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  15. THE AEROSPACE CORPORATION ,'

    Office of Legacy Management (LM)

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  16. THE AEROSPACE CORPORATION 1

    Office of Legacy Management (LM)

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  17. TID-4500, UC-4 C

    Office of Legacy Management (LM)

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  18. TITLE

    Office of Legacy Management (LM)

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  19. TITLE

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA groupTuba City, Arizona, DisposalFourthN V O'1 ~(3JlpV ProjectDear Mr.o l

  20. TITLE

    Office of Legacy Management (LM)

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  1. TITLE

    Office of Legacy Management (LM)

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  2. TITLE

    Office of Legacy Management (LM)

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  3. TITLE

    Office of Legacy Management (LM)

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  4. TITLE

    Office of Legacy Management (LM)

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  5. TITLE

    Office of Legacy Management (LM)

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  6. TITLE

    Office of Legacy Management (LM)

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  7. TITLE

    Office of Legacy Management (LM)

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  8. TITLE

    Office of Legacy Management (LM)

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  9. TITLE

    Office of Legacy Management (LM)

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  10. TITLE

    Office of Legacy Management (LM)

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  11. TITLE

    Office of Legacy Management (LM)

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  12. TITLE

    Office of Legacy Management (LM)

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  13. TITLE

    Office of Legacy Management (LM)

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  14. TITLE

    Office of Legacy Management (LM)

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  15. TITLE

    Office of Legacy Management (LM)

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  16. TITLE

    Office of Legacy Management (LM)

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  17. TITLE

    Office of Legacy Management (LM)

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  18. TITLE

    Office of Legacy Management (LM)

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  19. TITLE

    Office of Legacy Management (LM)

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  20. TITLE

    Office of Legacy Management (LM)

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  1. TITLE

    Office of Legacy Management (LM)

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  2. TITLE

    Office of Legacy Management (LM)

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  3. TITLE

    Office of Legacy Management (LM)

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  4. TITLE

    Office of Legacy Management (LM)

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  5. TITLE

    Office of Legacy Management (LM)

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  6. Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice

    SciTech Connect (OSTI)

    Kanclerz, A.; Chapman, J.D.

    1988-02-01T23:59:59.000Z

    The effect of treatments with the hypoxic cell radiosensitizers misonidazole (MISO), SR-2508, RSU-1069, and with the radioprotector WR-2721 on spontaneously disseminated Lewis lung carcinoma (LLC) and B16 melanoma (B16M) was investigated. Tumors were implanted into the tails of C57BL mice and were surgically removed after reaching volumes of approximately 40 mm3. This technique results in the induction of metastatic disease in lungs and at other anatomical sites and allows the independent treatment of disseminated tumor cells. The radiosensitizers and the radioprotector were administered 24 hr after surgery and animals were killed 14 and 30 days after removal of LLC and B16M, respectively. The time to death from spontaneous metastases was also measured. Both single treatments with large doses of MISO (1.0 g/kg) and fractionated therapy with smaller doses (0.5 g/kg on 5 consecutive days) promoted the formation of metastases to the lungs, lymph nodes and other organs. The survival times of MISO treated animals did not differ from control animals but manifestation of metastatic disease in the lungs and other organs occurred at earlier times. Administration of equitoxic doses of SR-2508 (3.0 g/kg) and RSU-1069 (0.1 g/kg) also promoted metastases formation. Mice treated with these radiosensitizers developed more metastases in the lungs and at other sites. Treatment with a single dose of WR-2721 (0.4 g/kg) promoted lung metastases but exerted a suppressive effect on lymph node tumors. When the radioprotector was given in fractionated schedules in three different doses (0.05 g/kg, 0.1 g/kg and 0.2 g/kg for 10 consecutive days) a slight enhancement of lung metastases and suppression of extrapulmonary metastases was observed.

  7. Nutritive value of hydrolyzed feather meal

    E-Print Network [OSTI]

    McCasland, William Edward

    1965-01-01T23:59:59.000Z

    al. 1955) indicates that pepsin digestibility, while furnishing valuable information regarding the nutritive value of some samples, may not always be reliable as a guide to feeding quality. Therefore, it was decided to determine if proteolytic... to sapplenenc Lhc hyarolyz . I f" lb. rs tn crcer to promote growth. I foe miso ac io compo at Ion;;r tf e I . ' theta, as previously shot!n, indicated that t he Feathers w re low in rsethrontne Lysins ?hi rid inc, and slightly Iow in t. yrosine ano phenyl...

  8. Autoradiographic study of tritium-labeled misonidazole in the mouse

    SciTech Connect (OSTI)

    Cobb, L.M.; Nolan, J.

    1989-04-01T23:59:59.000Z

    The localization of tritiated misonidazole metabolites in a number of normal tissues in the mouse is reported from autoradiography. The labeled misonidazole was injected at 750 or 75 mg/kg body weight (Rel. Sp. Act. 74 and 740 MBq/mg respectively). The grain count ratio, parenchyma:stroma, for selected tissues was: liver (centrilobular zone) 13; meibomian gland (acini) 68, (duct) 116; esophagus (keratinized layer) 61; enamel organ 17. It is concluded that there are a number of tissues which will accumulate MISO metabolites although they may not all be hypoxic.

  9. J319.xls

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy ChinaofSchaeferApril 1, 1999 InspectionVolunteers from the FederalMISO Project Number J319

  10. JULY 2015 POSTINGS | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy ChinaofSchaeferApril 1, 1999 InspectionVolunteers from the FederalMISO Project8,18,MayJuly

  11. Radiosensitization in vitro and in vivo by 3-nitrotriazoles

    SciTech Connect (OSTI)

    Shibamoto, Y.; Sakano, K.; Kimura, R.; Nishidai, T.; Nishimoto, S.; Ono, K.; Kagiya, T.; Abe, M.

    1986-07-01T23:59:59.000Z

    A series of 3-nitro-1,2,4-triazole derivatives bearing various types of side chain (R) at the N1-position (AK-2000 series) were synthesized and their radiosensitizing effect and toxicity in vitro and in vivo were investigated, in comparison with those of Misonidazole (MISO), SR-2508, and RSU-1069. Of the fifteen 3-nitrotriazoles tested, all had sensitizing effects in vitro on hypoxic V79 cells. Also, all but one had definite effects on solid EMT6/KU and SCCVII tumors in vivo. For many of the triazole compounds, the degree of radiosensitization in vitro and in vivo appeared identical. However, they were generally less efficient, both in vitro and in vivo, than the corresponding 2-nitroimidazoles, whereas their aerobic cytotoxicity and toxicity to mice (LD50/7) were comparable to those of the 2-nitroimidazoles. Considering the sensitizing effect and toxicity, AK-2123 (R = CH/sub 2/CONHC/sub 2/H/sub 4/OCH/sub 3/) may be as useful as MISO, but none of the triazoles have been proved to be superior to SR-2508.

  12. Evaluation of nitroimidazole hypoxic cell radiosensitizers in a human tumor cell line high in intracellular glutathione

    SciTech Connect (OSTI)

    DeGraff, W.G.; Russo, A.; Gamson, J.; Mitchell, J.B.

    1989-04-01T23:59:59.000Z

    Five nitroimidazole hypoxic cell radiosensitizers were evaluated in a human lung adenocarcinoma cell line (A549) whose GSH level was 8-fold higher than Chinese hamster V79 cells. One millimolar concentrations of Misonidazole (MISO), SR-2508, RSU-1164, RSU-1172, and Ro-03-8799 sensitized hypoxic A549 cells to radiation, with Ro-03-8799 giving the highest sensitizer enhancement ration (SER) (2.3). However, MISO, SR-2508 and Ro-03-8799 were less effective in this cell line than in V79 cells, presumably due to higher GSH content of the A549 cells. Increased hypoxic radiosensitization was seen with 0.1 mM Ro-03-8799 after GSH depletion by BSO as compared to 0.1 mM Ro-03-8799 alone (SER-1.8 vs 1.3). The combination of GSH depletion and 0.1 mM Ro-03-8799 was considerably more toxic than 0.1 mM or 1.0 mM Ro-03-8799 alone. This sensitivity was much greater than has been observed for SR-2508. These data show that Ro-03-8799 was the most efficient hypoxic cell radiosensitizer in a human tumor cell line considerably higher in GSH than the rodent cell lines often used in hypoxic radiosensitization studies. Thus, Ro-03-8799 may be a more effective hypoxic cell sensitizer in human tumors that are high in GSH.

  13. Factors associated with the preincubation effect of hypoxic cell sensitizers in vitro and their possible implications in chemosensitization

    SciTech Connect (OSTI)

    Roizin-Towle, L.; Biaglow, J.E.; Meltzer, H.L.; Varnes, M.E.

    1984-06-01T23:59:59.000Z

    The enhancement of melphalan toxicity was observed by preincubation of V-79-379A cells in spinner culture with multiple doses of misonidazole (miso) or SR-2508 under hypoxic conditions. Chemosensitization was shown to be a function of sensitizer concentration and duration of exposure to the alkylating agent. Cells preincubated with miso not only had lower levels of nonprotein thiols, but also were shown to have altered levels of intracellular calcium and a lower threshold to oxidative stress as measured by toxicity to cysteamine or H/sub 2/O/sub 2/. Preincubated cells, hypoxic cells, and cells receiving moderate hyperthermia (42.5/sup 0/C for 3 hr) all showed increased sensitivity to either cysteamine or H/sub 2/O/sub 2/. The increased killing of preincubated cells by cysteamine was shown to be similar to that of H/sub 2/O/sub 2/, and the dramatic reduction of cysteamine toxicity by catalase indicated H/sub 2/O/sub 2/ was the major reaction associated with this effect. These results indicate that preincubated cells exhibit a variety of biological effects that may significantly influence their response to further treatment with drugs or radiation, especially where peroxidative and free radical mechanisms are involved.

  14. Clinical trials with cyclophosphamide and misonidazole combination for maintaining treatment after radiation therapy of lung carcinoma

    SciTech Connect (OSTI)

    Busutti, L.; Breccia, A.; Stagni, G.; Gattavecchia

    1984-09-01T23:59:59.000Z

    Fifteen patients with inoperable non oat cell lung carcinoma, who had already been treated with telecobalt therapy in the mediastinum-hilar region, were treated with continuing therapy with misonidazole (MISO) and cyclophosphamide (Cy). MISO was administered in single doses of 1000 mg/m/sup 2/ and 500 mg/m/sup 2/, orally. Cy was administered in single doses of 500 mg/m/sup 2/ and 250 mg/m/sup 2/, i.v. This treatment was given every 4 weeks. All patients (15/15) suffered from hyporexia, nausea and vomiting within 48 hours from administration; furthermore, 2 patients had hemoragic cystitis, 2 had peripheral neurotoxicity, 3 had fever, and 2 had serious nervous depression. Leukopenia occurred in all patients immediately after drug administration, although it was not present in any patient by the time of the next administration. This clinical trial was concluded in December 1981. The follow-up at 18 months shows 7/15 cases of relapse. Eight of 15 patients are alive with progression of disease from 8 to 18 months.

  15. Cataclysmic Variables from SDSS I. The First Results

    E-Print Network [OSTI]

    Szkody, P; Agüeros, M A; Covarrubias, R; Bentz, M; Hawley, S; Margon, B; Voges, W; Henden, A A; Knapp, G R; Vanden Berk, Daniel E; Rest, A; Miknaitis, G; Magnier, E; Brinkmann, J; Csabai, I; Harvanek, M J; Hindsley, R; Hennessy, G S; Ivezic, Z; Kleinman, S J; Lamb, D Q; Long, D; Newman, P R; Neilsen, E H; Nichol, R C; Nitta, A; Schneider, D P; Snedden, S A; York, D G

    2002-01-01T23:59:59.000Z

    The commissioning year of the Sloan Digital Sky Survey has demonstrated that many cataclysmic variables have been missed in previous surveys with brighter limits. We report the identification of 22 cataclysmic variables, of which 19 are new discoveries and 3 are known systems (SW UMa, BH Lyn and Vir4). A compendium of positions, colors and characteristics of these systems obtained from the SDSS photometry and spectroscopy is presented along with data obtained during follow-up studies with the Apache Point Observatory (APO) and Manastash Ridge Observatory (MRO) telescopes. We have determined orbital periods for 3 of the new systems: two show dwarf nova outbursts, and the third is a likely magnetic system with eclipses of its region of line emission. Based on these results, we expect the completed survey to locate at least 400 new CVs. Most of these will be faint systems with low accretion rates that will provide new constraints on binary evolution models.

  16. Application of black-box models to HVAC systems for fault detection

    SciTech Connect (OSTI)

    Peitsman, H.C. [TNO Building and Construction Research, Delft (Netherlands). Dept. of Indoor Environment, Building Physics and Systems; Bakker, V.E. [Univ. of Twente, Enschede (Netherlands). Dept. of Computer Science

    1996-11-01T23:59:59.000Z

    This paper describes the application of black-box models for fault detection and diagnosis (FDD) in heating, ventilating, and air-conditioning (HVAC) systems. In this study, multiple-input/single-output (MISO) ARX models and artificial neural network (ANN) models are used. The ARX models are examined for different processes and subprocesses and compared with each other. Two types of models are established--system models and component models. In the case of system models, the HVAC system as a whole is regarded as a black box instead of as a collection of component models. With the component model type, the components of the HVAC system are regarded as separate black boxes.

  17. Fault detection in an air-handling unit using residual and recursive parameter identification methods

    SciTech Connect (OSTI)

    Lee, W.Y. [Korea Inst. of Energy Research, Taejon (Korea, Republic of); Park, C.; Kelly, G.E. [National Inst. of Standards and Technology, Gaithersburg, MD (United States)

    1996-11-01T23:59:59.000Z

    A scheme for detecting faults in an air-handling unit using residual and parameter identification methods is presented. Faults can be detected by comparing the normal or expected operating condition data with the abnormal, measured data using residuals. Faults can also be detected by examining unmeasurable parameter changes in a model of a controlled system using a system parameter identification technique. In this study, autoregressive moving average with exogenous input (ARMAX) and autoregressive with exogenous input (ARX) models with both single-input/single-output (SISO) and multi-input/single-output (MISO) structures are examined. Model parameters are determined using the Kalman filter recursive identification method. This approach is tested using experimental data from a laboratory`s variable-air-volume (VAV) air-handling unit operated with and without faults.

  18. Using Channel Output Feedback to Increase Throughput in Hybrid-ARQ

    E-Print Network [OSTI]

    Agrawal, Mayur; Love, David J; Balakrishnan, Venkataramanan

    2011-01-01T23:59:59.000Z

    Since its inclusion in the High Speed Downlink Packet Access (HSPDA) standard, the hybrid-ARQ protocol has become very popular in packet transmission schemes. Hybrid-ARQ combines the normal automatic repeat request (ARQ) method with error correction codes to increase reliability and throughput. The use of rate-compatible punctured turbo codes has been shown to work well for block fading channels. In this paper, we look at improving upon this performance using feedback information from the receiver; in particular, using a turbo code in conjunction with a proposed linear feedback code for the Rayleigh fading channels. The new hybrid-ARQ scheme is extended to various different multiple-antenna scenarios (MIMO/MISO/SISO) with varying amounts of feedback information. Simulations are given to illustrate gains in throughput.

  19. Interaction of nitroimidazole sensitizers with drug metabolizing enzymes--spectral and kinetic studies

    SciTech Connect (OSTI)

    Lee, F.Y.; Workman, P.

    1986-08-01T23:59:59.000Z

    We have investigated the effect of a range of 2-nitroimidazoles on CCNU metabolism, using an in vitro mouse liver microsomal preparation. CCNU is hydroxylated to at least 5 monohydroxylated metabolites. For the major metabolite, cis-4-hydroxy CCNU, values of Km and Vmax were 0.026 mM and 1.92 nmol/min/mg protein, respectively. MISO and other 2-nitroimidazoles inhibited the hydroxylation of CCNU in a dose-dependent manner and their potencies as inhibitors were governed by their lipophilicities. In order of increasing potency I50 values were 15.5, 6.4, 5.8, 1.4, 0.4, and 0.37 mM for SR 2508, Ro 03-8799, MISO, Ro 07-1902, Ro 07-1127, and BENZO, respectively. Chemosensitization potency correlated well with the extent of inhibition at achieved plasma concentrations in mice, suggesting a causal relationship between enzyme inhibition and chemosensitization. All the nitroimidazoles exhibited type II optical difference spectra with phenobarbitone-induced mouse liver microsomes. However, with increasing lipophilicity of the nitroimidazole both the wavelength at maximum absorbance (lambda max) and the isosbestic point of the type II spectrum were shifted to longer wavelengths, suggesting that a type I binding component may become more significant. Our previous work has shown that changes in CCNU pharmacokinetics contribute to chemosensitization by nitroimidazoles in mice, and that altered pharmacokinetics also occur in man. The present results provide strong evidence that the mechanism involves binding to liver microsomal cytochrome P-450, leading to inhibition of CCNU metabolism.

  20. Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice

    SciTech Connect (OSTI)

    Iwai, Hiroyuki; Matsuno, Etsuko (Daikin Industries, Ltd., Settsu (Japan)); Sasai, Keisuke; Abe, Mitsuyuki; Shibamoto, Yuta (Kyoto Univ. (Japan))

    1994-06-15T23:59:59.000Z

    In a clinical trial in which a 2-nitroimidazole radiosensitizer was administered repeatedly, the dose-limiting toxicity was found to be peripheral neuropathy. In the present study, the in vivo radiosensitizing activity of KU-2285 in combination with radiation dose fractionation, and the pharmacokinetics of cumulative dosing of KU-2285 in the peripheral nerves were examined. The ability of three nitroimidazoles, misonidazole (MISO), etanidazole (SR-2508) and KU-2285, to sensitize SCCVII tumors to radiation treatment has been compared for drug doses in the range 0-200 mg/kg. Single radiation doses or two different fractionation schedules (6 Gy/fractions [times] three fractions/48 h or 5 Gy/fractions [times] five fractions/48 h) were used; the tumor cell survival was determined using an in vivo/in vitro colony assay. The pharmacokinetics in the sciatic nerves were undertaken, when KU-2285 or etanidazole were injected at a dose of 200 mg/kg intravenously one, two, three, or four times at 2-h intervals. At less than 100 mg/kg, KU-2285 sensitized SCCVII tumors more than MISO and SR-2508 by fractionated irradiation. Evaluation of pharmacokinetics in the peripheral nerves showed that the apparent biological half-life of SR-2508 increased with the increases in the number of administrations, whereas that of KU-2285 became shorter. Since most clinical radiotherapy is given in small multiple fractions, KU-2285 appears to be a hypoxic cell radiosensitizer that could be useful in such regimens, and that poses no risk of chronic peripheral neurotoxicity. 12 refs., 5 figs., 1 tab.

  1. Addressing the challenges of plasma-surface interactions in NSTX-U*

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kaita, Robert; Abrams, Tyler; Jaworski, Michael; Lucia, Matthew; Nichols, Jacob H.; Skinner, Charles H.; Stotler, Daren; Allain, Jean Paul; Bedoya, Felipe

    2015-04-01T23:59:59.000Z

    The importance of conditioning plasma-facing components (PFCs) has long been recognized as a critical element in obtaining high-performance plasmas in magnetic confinement devices. Lithium coatings, for example, have been used for decades for conditioning PFCs. Since the initial studies on the Tokamak Fusion Test Reactor, experiments on devices with different aspect ratios and magnetic geometries like the National Spherical Torus Experiment (NSTX) continue to show the relationship between lithium PFCs and good confinement and stability. While such results are promising, their empirical nature do not reflect the detailed relationship between PFCs and the dynamic conditions that occur in the tokamakmore »environment. A first step developing an understanding such complexity will be taken in the upgrade to NSTX (NSTX-U) that is nearing completion. New measurement capabilities include the Materials Analysis and Particle Probe (MAPP) for in situ surface analysis of samples exposed to tokamak plasmas. The OEDGE suite of codes, for example, will provide a new way to model the underlying mechanisms for such material migration in NSTX-U. This will lead to a better understanding of how plasma-facing surfaces evolve during a shot, and how the composition of the plasma facing surface influences the discharge performance we observe. This paper will provide an overview of these capabilities, and highlight their importance for NSTX-U plans to transition from carbon to high-Z PFCs.« less

  2. Addressing the challenges of plasma-surface interactions in NSTX-U*

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kaita, Robert [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Abrams, Tyler [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Jaworski, Michael [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Lucia, Matthew [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Nichols, Jacob H. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Skinner, Charles H. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Stotler, Daren [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Allain, Jean Paul [University of Illinois, Urbana, IL (United States); Bedoya, Felipe [University of Illinois, Urbana, IL (United States)

    2015-04-01T23:59:59.000Z

    The importance of conditioning plasma-facing components (PFCs) has long been recognized as a critical element in obtaining high-performance plasmas in magnetic confinement devices. Lithium coatings, for example, have been used for decades for conditioning PFCs. Since the initial studies on the Tokamak Fusion Test Reactor, experiments on devices with different aspect ratios and magnetic geometries like the National Spherical Torus Experiment (NSTX) continue to show the relationship between lithium PFCs and good confinement and stability. While such results are promising, their empirical nature do not reflect the detailed relationship between PFCs and the dynamic conditions that occur in the tokamak environment. A first step developing an understanding such complexity will be taken in the upgrade to NSTX (NSTX-U) that is nearing completion. New measurement capabilities include the Materials Analysis and Particle Probe (MAPP) for in situ surface analysis of samples exposed to tokamak plasmas. The OEDGE suite of codes, for example, will provide a new way to model the underlying mechanisms for such material migration in NSTX-U. This will lead to a better understanding of how plasma-facing surfaces evolve during a shot, and how the composition of the plasma facing surface influences the discharge performance we observe. This paper will provide an overview of these capabilities, and highlight their importance for NSTX-U plans to transition from carbon to high-Z PFCs.

  3. Advanced Communication and Control Solutions of Distributed Energy Resources (DER)

    SciTech Connect (OSTI)

    Asgeirsson, Haukur; Seguin, Richard; Sherding, Cameron; de Bruet, Andre, G.; Broadwater, Robert; Dilek, Murat

    2007-01-10T23:59:59.000Z

    This report covers work performed in Phase II of a two phase project whose objective was to demonstrate the aggregation of multiple Distributed Energy Resources (DERs) and to offer them into the energy market. The Phase I work (DE-FC36-03CH11161) created an integrated, but distributed, system and procedures to monitor and control multiple DERs from numerous manufacturers connected to the electric distribution system. Procedures were created which protect the distribution network and personnel that may be working on the network. Using the web as the communication medium for control and monitoring of the DERs, the integration of information and security was accomplished through the use of industry standard protocols such as secure SSL,VPN and ICCP. The primary objective of Phase II was to develop the procedures for marketing the power of the Phase I aggregated DERs in the energy market, increase the number of DER units, and implement the marketing procedures (interface with ISOs) for the DER generated power. The team partnered with the Midwest Independent System Operator (MISO), the local ISO, to address the energy market and demonstrate the economic dispatch of DERs in response to market signals. The selection of standards-based communication technologies offers the ability of the system to be deployed and integrated with other utilities’ resources. With the use of a data historian technology to facilitate the aggregation, the developed algorithms and procedures can be verified, audited, and modified. The team has demonstrated monitoring and control of multiple DERs as outlined in phase I report including procedures to perform these operations in a secure and safe manner. In Phase II, additional DER units were added. We also expanded on our phase I work to enhance communication security and to develop the market model of having DERs, both customer and utility owned, participate in the energy market. We are proposing a two-part DER energy market model--a utility need business model and an independent energy aggregator-business model. The approach of developing two group models of DER energy participation in the market is unique. The Detroit Edison (DECo, Utility)-led team includes: DTE Energy Technologies (Dtech, DER provider), Electrical Distribution Design (EDD, Virginia Tech company supporting EPRI’s Distribution Engineering Workstation, DEW), Systems Integration Specialists Company (SISCO, economic scheduling and real-time protocol integrator), and OSIsoft (PI software system for managing real-time information). This team is focused on developing the application engineering, including software systems necessary for DER’s integration, control and sale into the market place. Phase II Highlights Installed and tested an ICCP link with SSL (security) between DECo, the utility, and DTE Energy Technologies (DTECH), the aggregator, making DER data available to the utility for both monitoring and control. Installed and tested PI process book with circuit & DER operational models for DECo SOC/ROC operator’s use for monitoring of both utility circuit and customer DER parameters. The PI Process Book models also included DER control for the DECo SOC/ROC operators, which was tested and demonstrated control. The DER Tagging and Operating Procedures were developed, which allowed that control to be done in a safe manner, were modified for required MOC/MISO notification procedures. The Distribution Engineering Workstation (DEW) was modified to include temperature normalized load research statistics, using a 30 hour day-ahead weather feed. This allowed day-ahead forecasting of the customer load profile and the entire circuit to determine overload and low voltage problems. This forecast at the point of common coupling was passed to DTech DR SOC for use in their economic dispatch algorithm. Standard Work Instructions were developed for DER notification, sale, and operation into the MISO market. A software mechanism consisting of a suite of new and revised functionality was developed that integrated with the local ISO such that offe

  4. A Digital-Receiver for the Murchison Widefield Array

    E-Print Network [OSTI]

    Prabu, Thiagaraj; Roshi, D Anish; Kamini, P A; Madhavi, S; Emrich, David; Crosse, Brian; Williams, Andrew J; Waterson, Mark; Deshpande, Avinash A; Shankar, N Udaya; Subrahmanyan, Ravi; Briggs, Frank H; Goeke, Robert F; Tingay, Steven J; Johnston-Hollitt, Melanie; R, Gopalakrishna M; Morgan, Edward H; Pathikulangara, Joseph; Bunton, John D; Hampson, Grant; Williams, Christopher; Ord, Stephen M; Wayth, Randall B; Kumar, Deepak; Morales, Miguel F; deSouza, Ludi; Kratzenberg, Eric; Pallot, D; McWhirter, Russell; Hazelton, Bryna J; Arcus, Wayne; Barnes, David G; Bernardi, Gianni; Booler, T; Bowman, Judd D; Cappallo, Roger J; Corey, Brian E; Greenhill, Lincoln J; Herne, David; Hewitt, Jacqueline N; Kaplan, David L; Kasper, Justin C; Kincaid, Barton B; Koenig, Ronald; Lonsdale, Colin J; Lynch, Mervyn J; Mitchell, Daniel A; Oberoi, Divya; Remillard, Ronald A; Rogers, Alan E; Salah, Joseph E; Sault, Robert J; Stevens, Jamie B; Tremblay, S E; Webster, Rachel L; Whitney, Alan R; Wyithe, Stuart B

    2015-01-01T23:59:59.000Z

    An FPGA-based digital-receiver has been developed for a low-frequency imaging radio interferometer, the Murchison Widefield Array (MWA). The MWA, located at the Murchison Radio-astronomy Observatory (MRO) in Western Australia, consists of 128 dual-polarized aperture-array elements (tiles) operating between 80 and 300\\,MHz, with a total processed bandwidth of 30.72 MHz for each polarization. Radio-frequency signals from the tiles are amplified and band limited using analog signal conditioning units; sampled and channelized by digital-receivers. The signals from eight tiles are processed by a single digital-receiver, thus requiring 16 digital-receivers for the MWA. The main function of the digital-receivers is to digitize the broad-band signals from each tile, channelize them to form the sky-band, and transport it through optical fibers to a centrally located correlator for further processing. The digital-receiver firmware also implements functions to measure the signal power, perform power equalization across ...

  5. Cut-off free finite zero-point vacuum energy and the cosmological missing mass problem

    E-Print Network [OSTI]

    N. Kumar

    1999-04-22T23:59:59.000Z

    As the mass-energy is universally self-gravitating, the gravitational binding energy must be subtracted self-consistently from its bare mass value so as to give the physical gravitational mass. Such a self-consistent gravitational self-energy correction can be made non-perturbatively by the use of a gravitational `charging' technique, where we calculate the incremental change $dm$ of the physical mass of the cosmological object, of size $r_o$ due to the accretion of a bare mass $dM$, corresponding to the gravitational coupling-in of the successive zero-point vacuum modes, i.e., of the Casimir energy, whose bare value $\\Sigma_{\\bf k} \\hbar ck$ is infinite. Integrating the `charging' equation, $dm = dM - (3\\alpha/5)Gm\\Delta M/r_o c^2$, we get a gravitational mass for the cosmological object that remains finite even in the limit of the infinite zero-point vacuum energy, i.e., without any ultraviolet cut-off imposed. Here $\\alpha$ is a geometrical factor of order unity. Also, setting $r_o = c/H$, the Hubble length, we get the corresponding cosmological density parameter $\\Omega \\simeq 1$, without any adjustable parameter. The cosmological significance of this finite and unique contribution of the otherwise infinite zero-point vacuum energy to the density parameter can hardly be overstated.

  6. DURABLE GLASS FOR THOUSANDS OF YEARS

    SciTech Connect (OSTI)

    Jantzen, C.

    2009-12-04T23:59:59.000Z

    The durability of natural glasses on geological time scales and ancient glasses for thousands of years is well documented. The necessity to predict the durability of high level nuclear waste (HLW) glasses on extended time scales has led to various thermodynamic and kinetic approaches. Advances in the measurement of medium range order (MRO) in glasses has led to the understanding that the molecular structure of a glass, and thus the glass composition, controls the glass durability by establishing the distribution of ion exchange sites, hydrolysis sites, and the access of water to those sites. During the early stages of glass dissolution, a 'gel' layer resembling a membrane forms through which ions exchange between the glass and the leachant. The hydrated gel layer exhibits acid/base properties which are manifested as the pH dependence of the thickness and nature of the gel layer. The gel layer ages into clay or zeolite minerals by Ostwald ripening. Zeolite mineral assemblages (higher pH and Al{sup 3+} rich glasses) may cause the dissolution rate to increase which is undesirable for long-term performance of glass in the environment. Thermodynamic and structural approaches to the prediction of glass durability are compared versus Ostwald ripening.

  7. DEVELOPMENT OF GLASS MATRICES FOR HLW RADIOACTIVE WASTES

    SciTech Connect (OSTI)

    Jantzen, C.

    2010-03-18T23:59:59.000Z

    Vitrification is currently the most widely used technology for the treatment of high level radioactive wastes (HLW) throughout the world. Most of the nations that have generated HLW are immobilizing in either borosilicate glass or phosphate glass. One of the primary reasons that glass has become the most widely used immobilization media is the relative simplicity of the vitrification process, e.g. melt waste plus glass forming frit additives and cast. A second reason that glass has become widely used for HLW is that the short range order (SRO) and medium range order (MRO) found in glass atomistically bonds the radionuclides and governs the melt properties such as viscosity, resistivity, sulphate solubility. The molecular structure of glass controls contaminant/radionuclide release by establishing the distribution of ion exchange sites, hydrolysis sites, and the access of water to those sites. The molecular structure is flexible and hence accounts for the flexibility of glass formulations to waste variability. Nuclear waste glasses melt between 1050-1150 C which minimizes the volatility of radioactive components such as Tc{sup 99}, Cs{sup 137}, and I{sup 129}. Nuclear waste glasses have good long term stability including irradiation resistance. Process control models based on the molecular structure of glass have been mechanistically derived and have been demonstrated to be accurate enough to control the world's largest HLW Joule heated ceramic melter in the US since 1996 at 95% confidence.

  8. Short run effects of a price on carbon dioxide emissions from U.S. electric generators

    SciTech Connect (OSTI)

    Adam Newcomer; Seth A. Blumsack; Jay Apt; Lester B. Lave; M. Granger Morgan [Carnegie Mellon University, Pittsburgh, PA (United States). Carnegie Mellon Electricity Industry Center

    2008-05-01T23:59:59.000Z

    The price of delivered electricity will rise if generators have to pay for carbon dioxide emissions through an implicit or explicit mechanism. There are two main effects that a substantial price on CO{sub 2} emissions would have in the short run (before the generation fleet changes significantly). First, consumers would react to increased price by buying less, described by their price elasticity of demand. Second, a price on CO{sub 2} emissions would change the order in which existing generators are economically dispatched, depending on their carbon dioxide emissions and marginal fuel prices. Both the price increase and dispatch changes depend on the mix of generation technologies and fuels in the region available for dispatch, although the consumer response to higher prices is the dominant effect. We estimate that the instantaneous imposition of a price of $35 per metric ton on CO{sub 2} emissions would lead to a 10% reduction in CO{sub 2} emissions in PJM and MISO at a price elasticity of -0.1. Reductions in ERCOT would be about one-third as large. Thus, a price on CO{sub 2} emissions that has been shown in earlier work to stimulate investment in new generation technology also provides significant CO{sub 2} reductions before new technology is deployed at large scale. 39 refs., 4 figs., 2 tabs.

  9. The prostaglandin E{sub 1} analog, misoprostol, a normal tissue protector, does not protect four murine tumors in vivo from radiation injury

    SciTech Connect (OSTI)

    Hanson, W.R.; Zhen, W.; Geng, L. [Loyola Univ. Chicago and Hines Veterans Administration Medical Centers, Hines, IL (United States)] [and others

    1995-06-01T23:59:59.000Z

    The clinical development of radioprotectors, such as misoprostol, to protect normal tissue during cancer treatment must proceed with the assurance that tumors are not protected similarly or significantly. To provide data on this critical question, radiation-induced growth delay with or without the presence of misoprostol was measured in four murine tumors grown in the flanks of mice: the Lewis lung carcinoma, M-5076 ovarian sarcoma, FSA and NFSA. The effect of misoprostol on the tumor control dose (TCD{sub 50}) of radiation was measured in FSA-bearing mice with or without prior treatment with the nonsteroidal anti-inflammatory agent, indomethacin. Misoprostol did not influence the in vivo growth of any of the four tumors, nor did it protect any of the tumors from radiation-induced growth delay. Likewise, there was no increase in the radiation TCD{sub 50} to treat the FSA in vivo in control or indomethacin-treated tumor-bearing mice. To measure any possible influence of tumor burden on the protective effect of miso-prostol on normal tissue in mice, the protective effect of misoprostol on the survival of intestinal clonogenic cells was measured in M-5076-bearing mice and found to be the same as in non-tumor-bearing mice. These data suggest that misoprostol protects normal tissue in mice without protecting at least four experimental murine tumors. The data support the contention that misoprostol can achieve therapeutic gain by protecting normal tissues without protecting tumors. 44 refs., 5 figs., 1 tab.

  10. RTO Briefing

    SciTech Connect (OSTI)

    Steve Wiese

    2003-11-01T23:59:59.000Z

    OAK-B135 Transmission Updates The summary of this report is: (1) Small generators are not happy with FERC's Small Generator Interconnection NOPR, saying the proposed rule ignores much of the consensus developed between small generators and transmission owners during the ANOPR process. California wind generators seek clarification that repowering an existing facility or changing contract terms would not trigger a reevaluation of the interconnection. (2) The choices of former Alliance companies about which RTO to join, MISO or PJM, and whether they can obtain approval from states to do so, has created such a tangle that FERC held two days of hearings at the end of September on the issues and options for resolving them. But in addition to some constructive input, the hearings produced even more uncertainty, with transmission companies announcing their need to reassess their own RTO commitments depending on the decisions of others. (3) In the West, the Seams Steering Group--Western Interconnection (SSG-WI) completed a west-wide transmission study with a renewable energy scenario, the California ISO received FERC's approval on its market redesign proposal, and RTO West worked toward finalizing high-level consensus documents describing Day 1 implementation of the proposed RTO. (4) In Texas, ERCOT began $157 million in upgrades to the transmission system around McCamey--increasing capacity in and out of the area enough to handle existing wind projects there.

  11. Importance of tumor affinity of nitroazoles in hypoxic radiosensitization

    SciTech Connect (OSTI)

    Kagiya, T.; Nishimoto, S.; Shibamoto, Y.; Wang, J.; Zhou, L.; He, Y.L.; Sasai, K.; Takahashi, M.; Abe, M.

    1989-04-01T23:59:59.000Z

    In vitro and in vivo sensitizing activities of a variety of nitroazole derivatives including misonidazole (MISO), SR-2508, and RSU-1069 were correlated by the aid of pharmacokinetic measurements of the drug uptake in animal solid tumors. The sensitizer enhancement ratio in vivo (SERvivo) on solid tumors increased linearly with the square root of administrated dose (Ds). The specific activity (A) in vivo of nitroazoles was evaluated from the square-root empirical relationship, SERvivo = 1.00 + A D1/2S. The intratumor concentration of nitroazoles at a given time t after administration was in proportion to the DS, in which the proportional constant was defined as the tumor-affinity factor FT,t. The absolute molar activity alpha M defined by A(M/FT,t)1/2, where M is the molecular weight of nitroazoles, showed a linear relationship with the SER in vitro (SERvitro) at 1 mM of sensitizers. The sensitizer dose required to achieve an SERvivo of 1.5 (DS,1.5) decreased and thus the overall sensitizing efficiency on animal solid tumors increased as the FT,t became greater.

  12. Modeling and identification of parallel nonlinear systems: Structural classification and parameter estimation methods

    SciTech Connect (OSTI)

    Chen, H.W. (Los Alamos National Lab., NM (United States). Biophysics Group M715)

    1995-01-01T23:59:59.000Z

    Structural classification and parameter estimation (SCPE) methods are used for studying single-input single-output (SISO) parallel linear-nonlinear-linear (LNL), linear-nonlinear (LN), and nonlinear-linear (NL) system models from input-output (I-O) measurements. The uniqueness of the I-O mappings (see the definition of the I-O mapping in Section 3-A) of some model structures is discussed. The uniqueness of the I-O mappings (see the definition of the I-O mapping in Section 3-A) of some model structures is discussed. The uniqueness of I-O mappings of different models tells them in what conditions different model structures can be differentiated from one another. Parameter uniqueness of the I-O mapping of a given structural model is also discussed, which tells the authors in what conditions a given model's parameters can be uniquely estimated from I-O measurements. These methods are then generalized so that they can be used to study single-input multi-output (SIMO), multi-input single-output (MISO), as well as multi-input multi-output (MIMO) nonlinear system models. Parameter estimation of the two-input single-output nonlinear system model (denoted as the 2f-structure in 2 cited references), which was left unsolved previously, can now be obtained using the newly derived algorithms. Applications of SCPE methods for modeling visual cortical neurons, system fault detection, modeling and identification of communication networks, biological systems, and natural and artificial neural networks are also discussed. The feasibility of these methods is demonstrated using simulated examples. SCPE methods presented in this paper can be further developed to study more complicated block-structures models, and will therefore have future potential for modeling and identifying highly complex multi-input multi-output nonlinear systems.

  13. Regulatory Policy and Markets for Energy Storage in North America

    SciTech Connect (OSTI)

    Kintner-Meyer, Michael CW

    2014-05-14T23:59:59.000Z

    The last 5 years have been one of the most exciting times for the energy storage industry. We have seen significant advancements in the regulatory process to make accommodations for valuing and monetizing energy storage for what it provides to the grid. The most impactful regulatory decision for the energy storage industry has come from California, where the California Public Utilities Commission issued a decision that mandates procurement requirements of 1.325 GW for energy storage to 3 investor-own utilities in 4 stages: in 2014, 2016, 2018, and 2020. Furthermore, at the Federal level, FERC’s Order 755, requires the transmission operators to develop pay for performance tariffs for ancillary services. This has had direct impact on the market design of US competitive wholesale markets and the monetization of fast responding grid assets. While this order is technology neutral, it clearly plays into the fast-responding capability of energy storage technologies. Today PJM, CAISO, MISO, NYISO, and NE-ISO have implemented Order 755 and offer new tariff for regulation services based on pay-for-performance principles. Furthermore, FERC Order 784, issued in July 2013 requires transmission providers to consider speed and accuracy in determining the requirements for ancillary services. In November 2013, FERC issued Order 972, which revises the small generator interconnection agreement which declares energy storage as a power source. This order puts energy storage on par with existing generators. This paper will discuss the implementation of FERC’s Pay for Performance Regulation order at all ISOs in the U.S. under FERC regulatory authority (this excludes ERCOT). Also discussed will be the market impacts and overall impacts on the NERC regulation performance indexes. The paper will end with a discussion on the California and Ontario, Canada procurement mandates and the opportunity that it may present to the energy storage industry.

  14. Wind Energy Forecasting: A Collaboration of the National Center for Atmospheric Research (NCAR) and Xcel Energy

    SciTech Connect (OSTI)

    Parks, K.; Wan, Y. H.; Wiener, G.; Liu, Y.

    2011-10-01T23:59:59.000Z

    The focus of this report is the wind forecasting system developed during this contract period with results of performance through the end of 2010. The report is intentionally high-level, with technical details disseminated at various conferences and academic papers. At the end of 2010, Xcel Energy managed the output of 3372 megawatts of installed wind energy. The wind plants span three operating companies1, serving customers in eight states2, and three market structures3. The great majority of the wind energy is contracted through power purchase agreements (PPAs). The remainder is utility owned, Qualifying Facilities (QF), distributed resources (i.e., 'behind the meter'), or merchant entities within Xcel Energy's Balancing Authority footprints. Regardless of the contractual or ownership arrangements, the output of the wind energy is balanced by Xcel Energy's generation resources that include fossil, nuclear, and hydro based facilities that are owned or contracted via PPAs. These facilities are committed and dispatched or bid into day-ahead and real-time markets by Xcel Energy's Commercial Operations department. Wind energy complicates the short and long-term planning goals of least-cost, reliable operations. Due to the uncertainty of wind energy production, inherent suboptimal commitment and dispatch associated with imperfect wind forecasts drives up costs. For example, a gas combined cycle unit may be turned on, or committed, in anticipation of low winds. The reality is winds stayed high, forcing this unit and others to run, or be dispatched, to sub-optimal loading positions. In addition, commitment decisions are frequently irreversible due to minimum up and down time constraints. That is, a dispatcher lives with inefficient decisions made in prior periods. In general, uncertainty contributes to conservative operations - committing more units and keeping them on longer than may have been necessary for purposes of maintaining reliability. The downside is costs are higher. In organized electricity markets, units that are committed for reliability reasons are paid their offer price even when prevailing market prices are lower. Often, these uplift charges are allocated to market participants that caused the inefficient dispatch in the first place. Thus, wind energy facilities are burdened with their share of costs proportional to their forecast errors. For Xcel Energy, wind energy uncertainty costs manifest depending on specific market structures. In the Public Service of Colorado (PSCo), inefficient commitment and dispatch caused by wind uncertainty increases fuel costs. Wind resources participating in the Midwest Independent System Operator (MISO) footprint make substantial payments in the real-time markets to true-up their day-ahead positions and are additionally burdened with deviation charges called a Revenue Sufficiency Guarantee (RSG) to cover out of market costs associated with operations. Southwest Public Service (SPS) wind plants cause both commitment inefficiencies and are charged Southwest Power Pool (SPP) imbalance payments due to wind uncertainty and variability. Wind energy forecasting helps mitigate these costs. Wind integration studies for the PSCo and Northern States Power (NSP) operating companies have projected increasing costs as more wind is installed on the system due to forecast error. It follows that reducing forecast error would reduce these costs. This is echoed by large scale studies in neighboring regions and states that have recommended adoption of state-of-the-art wind forecasting tools in day-ahead and real-time planning and operations. Further, Xcel Energy concluded reduction of the normalized mean absolute error by one percent would have reduced costs in 2008 by over $1 million annually in PSCo alone. The value of reducing forecast error prompted Xcel Energy to make substantial investments in wind energy forecasting research and development.