Sample records for manager toiyabe nf

  1. 1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011 by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011 Splash Mitigation for comparison & final determination #12;3 Managed by UT-Battelle for the U.S. Department of Energy NF Splash

  2. 1 Managed by UT-Battelle for the U.S. Department of Energy NF-IDS Videoconference 2 Jun 2009

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF-IDS Videoconference 2 Jun 2009 by UT-Battelle for the U.S. Department of Energy NF-IDS Videoconference 2 Jun 2009 Purpose · Compare · Compilation of magnet geometry data #12;3 Managed by UT-Battelle for the U.S. Department of Energy NF

  3. 1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09 Cryostat 2 Front Drain Mercury Vessel Concept Matthew F. Glisson Van Graves #12;2 Managed by UT-Battelle;3 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09 Cross Section

  4. /7 soF'/t,,,,n,re D toPm NT". Using a Co nf=guration Management Tool to CoordInate

    E-Print Network [OSTI]

    Grinter, Rebecca Elizabeth

    for coordination they provide, and their role in supporting a model of work. KEYWORDS: configuration management (CM of coordinating group work. This particular technology, a configuration management (CM) tool, incorporates begins with a description of configuration management, and how it involves coordinating the work

  5. USFS Humboldt-Toiyabe National Forest | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-fTri Global Energy LLC Place: Dallas,UGIURDBCOSO EGS PROJECT | Open

  6. NF Energy Saving Corp | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I Geothermal Pwer PlantMunhall, Pennsylvania: Energy Resources JumpNEF Advisors LLC JumpNF Energy Saving Corp

  7. NF-?B Fans the Flames of Lung Carcinogenesis

    E-Print Network [OSTI]

    Jacks, Tyler E.

    This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-?B and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating ...

  8. Universality of the Nf=2 Running Coupling

    E-Print Network [OSTI]

    K. Murano; S. Aoki; S. Takeda; Y. Taniguchi

    2009-03-06T23:59:59.000Z

    We investigate universality of the Nf=2 running coupling in the Sch\\"odinger functional scheme, by calculating the step scaling function in lattice QCD with the renorm alization group (RG) improved gauge action at both weak(u=0.9796) and strong(u=3.3340) couplings, where u=\\bar{g}^2_SF with \\bar{g}_SF being the running coupling in this scheme. In our main calculations, we use the tree-level value for O(a) improvement coefficients of boundary gauge fields. In addition we employ the 1-loop value for them in order to see how scaling behaviours are affected by them. In the continuum limit, the step scaling function obtained from the RG improved gauge actions agrees with the previous result obtained from the plaquette action within errors at both couplings, though errors of our result are larger. Combined fits using all data with the RG improved action as well as the plaquette action reduce errors in the continuum limit by 2% at the weak coupling and 22% at the strong coupling.

  9. Haploid reporter screens aimed at identification of NF-kappaB regulators

    E-Print Network [OSTI]

    Lee, Clarissa Ci

    2014-01-01T23:59:59.000Z

    Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such ...

  10. Managed by UT-Battelle for the Department of Energy

    E-Print Network [OSTI]

    McDonald, Kirk

    Managed by UT-Battelle for the Department of Energy Neutrino Factory Mercury Containment Concepts V;2 Managed by UT-Battelle for the Department of Energy HPT Workshop, 6 Nov 2008 Outline · Neutrino Factory.14 Dimensions in cm #12;6 Managed by UT-Battelle for the Department of Energy HPT Workshop, 6 Nov 2008 NF Hg Jet

  11. Managed by UT-Battelle for the Department of Energy

    E-Print Network [OSTI]

    McDonald, Kirk

    Managed by UT-Battelle for the Department of Energy Design and Operational Features of a Mercury CERN #12;2 Managed by UT-Battelle for the Department of Energy Contributors · Tom McManamy, Chief Dec 08 #12;3 Managed by UT-Battelle for the Department of Energy NF-IDS Meeting 15 Dec 08 Outline

  12. Porcine arterivirus activates the NF-{kappa}B pathway through I{kappa}B degradation

    SciTech Connect (OSTI)

    Lee, Sang-Myeong [Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States); Kleiboeker, Steven B. [Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States) and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States)]. E-mail: KleiboekerS@Missouri.edu

    2005-11-10T23:59:59.000Z

    Nuclear factor-kappaB (NF-{kappa}B) is a critical regulator of innate and adaptive immune function as well as cell proliferation and survival. The present study demonstrated for the first time that a virus belonging to the Arteriviridae family activates NF-{kappa}B in MARC-145 cells and alveolar macrophages. In porcine reproductive and respiratory syndrome virus (PRRSV)-infected cells, NF-{kappa}B activation was characterized by translocation of NF-{kappa}B from the cytoplasm to the nucleus, increased DNA binding activity, and NF-{kappa}B-regulated gene expression. NF-{kappa}B activation was increased as PRRSV infection progressed and in a viral dose-dependent manner. UV-inactivation of PRRSV significantly reduced the level of NF-{kappa}B activation. Degradation of I{kappa}B protein was detected late in PRRSV infection, and overexpression of the dominant negative form of I{kappa}B{alpha} (I{kappa}B{alpha}DN) significantly suppressed NF-{kappa}B activation induced by PRRSV. However, I{kappa}B{alpha}DN did not affect viral replication and viral cytopathic effect. PRRSV infection induced oxidative stress in cells by generating reactive oxygen species (ROS), and antioxidants inhibited NF-{kappa}B DNA binding activity in PRRSV-infected cells, suggesting ROS as a mechanism by which NF-{kappa}B was activated by PRRSV infection. Moreover, NF-{kappa}B-dependent expression of matrix metalloproteinase (MMP)-2 and MMP-9 was observed in PRRSV-infected cells, an observation which implies that NF-{kappa}B activation is a biologically significant aspect of PRRSV pathogenesis. The results presented here provide a basis for understanding molecular pathways of pathology and immune evasion associated with disease caused by PRRSV.

  13. Smoothing single-crystalline SiC surfaces by reactive ion etching using pure NF{sub 3} and NF{sub 3}/Ar mixture gas plasmas

    SciTech Connect (OSTI)

    Tasaka, Akimasa, E-mail: aki-tasaka-load@yahoo.co.jp [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321, Japan and Department of Applied Chemistry, Graduate School of Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Kotaka, Yuki [Department of Applied Chemistry, Graduate School of Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Oda, Atsushi; Saito, Morihiro [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Tojo, Tetsuro [Toyo Tanso Co, Ltd., 5-7-2 Takeshima, Nishi yodogawa-ku, Osaka 555-0011 (Japan); Inaba, Minoru [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321, Japan and Department of Applied Chemistry, Graduate School of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan)

    2014-09-01T23:59:59.000Z

    In pure NF{sub 3} plasma, the etching rates of four kinds of single-crystalline SiC wafer etched at NF{sub 3} pressure of 2?Pa were the highest and it decreased with an increase in NF{sub 3} pressure. On the other hand, they increased with an increase in radio frequency (RF) power and were the highest at RF power of 200?W. A smooth surface was obtained on the single-crystalline 4H-SiC after reactive ion etching at NF{sub 3}/Ar gas pressure of 2?Pa and addition of Ar to NF{sub 3} plasma increased the smoothness of SiC surface. Scanning electron microscopy observation revealed that the number of pillars decreased with an increase in the Ar-concentration in the NF{sub 3}/Ar mixture gas. The roughness factor (R{sub a}) values were decreased from 51.5?nm to 25.5?nm for the As-cut SiC, from 0.25?nm to 0.20?nm for the Epi-SiC, from 5.0?nm to 0.7?nm for the Si-face mirror-polished SiC, and from 0.20?nm to 0.16?nm for the C-face mirror-polished SiC by adding 60% Ar to the NF{sub 3} gas. Both the R{sub a} values of the Epi- and the C-face mirror-polished wafer surfaces etched using the NF{sub 3}/Ar (40:60) plasma were similar to that treated with mirror polishing, so-called the Catalyst-Referred Etching (CARE) method, with which the lowest roughness of surface was obtained among the chemical mirror polishing methods. Etching duration for smoothing the single-crystalline SiC surface using its treatment was one third of that with the CARE method.

  14. IKK{epsilon} modulates RSV-induced NF-{kappa}B-dependent gene transcription

    SciTech Connect (OSTI)

    Bao Xiaoyong; Indukuri, Hemalatha; Liu Tianshuang; Liao Suiling [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Tian, Bing; Brasier, Allan R. [Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX (United States); Garofalo, Roberto P. [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States); Casola, Antonella, E-mail: ancasola@utmb.ed [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States)

    2010-12-20T23:59:59.000Z

    Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-{kappa}B (NF-{kappa}B). In this study we have investigated the role of the non canonical I{kappa}B kinase (IKK){epsilon} in modulating RSV-induced NF-{kappa}B activation. Our results show that inhibition of IKK{epsilon} activation results in significant impairment of viral-induced NF-{kappa}B-dependent gene expression, through a reduction in NF-{kappa}B transcriptional activity, without changes in nuclear translocation or DNA-binding activity. Absence of IKK{epsilon} results in a significant decrease of RSV-induced NF-{kappa}B phosphorylation on serine 536, a post-translational modification important for RSV-induced NF-{kappa}B-dependent gene expression, known to regulate NF-{kappa}B transcriptional activity without affecting nuclear translocation. This study identifies a novel mechanism by which IKK{epsilon} regulates viral-induced cellular signaling.

  15. Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness

    E-Print Network [OSTI]

    O'Dea, Ellen Louise

    2010-01-01T23:59:59.000Z

    19-26. O'Dea, E. and Hoffmann, A. 2009. NF-kappaB signaling.J.D. , Levchenko, A. , and Hoffmann, A. 2007. A homeostaticS.L. , Cheng, C. , and Hoffmann, A. 2007. A temporal code

  16. Response and Resistance to NF-?B Inhibitors in Mouse Models of Lung Adenocarcinoma

    E-Print Network [OSTI]

    Xue, Wen

    Lung adenocarcinoma is a leading cause of cancer death worldwide. We recently showed that genetic inhibition of the NF-?B pathway affects both the initiation and the maintenance of lung cancer, identifying this pathway as ...

  17. Requirement for NF-?B signalling in a mouse model of lung adenocarcinoma

    E-Print Network [OSTI]

    Meylan, Etienne

    NF-?B transcription factors function as crucial regulators of inflammatory and immune responses as well as of cell survival. They have also been implicated in cellular transformation and tumorigenesis. However, despite ...

  18. A test of first order scaling in Nf=2 QCD

    E-Print Network [OSTI]

    G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

    2007-09-30T23:59:59.000Z

    We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

  19. Sci. Aging Knowl. Environ., Vol. 2004, Issue 34, pp. nf78, 25 August 2004 [DOI: 10.1126/sageke.2004.34.nf78

    E-Print Network [OSTI]

    Seroude, Laurent

    : They scrubbed fly eggs with alcohol, fed the animals irradiated food, and kept them in sterile containers: http://sageke.sciencemag.org/cgi/content/full/2004/34/nf78 Nasty germs in fast-food burgers can kill direction--from fare that included antibiotics to "dirty" food--extended fly life on day 2 but not on day 4

  20. NF-?B1 Inhibits TLR-Induced IFN-? Production in Macrophages Through TPL-2-dependent ERK Activation

    E-Print Network [OSTI]

    Yang, Huei-Ting

    Although NF-?B1 p50/p105 has critical roles in immunity, the mechanism by which NF-?B1 regulates inflammatory responses is unclear. In this study, we analyzed the gene expression profile of LPS-stimulated Nfkb1?/? macrophages ...

  1. XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NF?B activation

    E-Print Network [OSTI]

    Lin, Fang; Ghislat, Ghita; Luo, Shouqing; Renna, Maurizio; Siddiqi, Farah; Rubinsztein, David C.

    2015-02-10T23:59:59.000Z

    ). In both steady state and stimulated conditions with TGF? that activates NF?B through TAK1 (33), nei- ther the overexpression of XIAP nor its knockdown affected the transcriptional activation of the NF?B promoter (Fig. 3B, top). The effect of TGF?...

  2. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07T23:59:59.000Z

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  3. Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1 Machine tools : Safety : Hydraulic presses

    E-Print Network [OSTI]

    Association Française de Normalisation. Paris

    2009-01-01T23:59:59.000Z

    Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1

  4. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt–NF-?B and MAPK signaling pathways

    SciTech Connect (OSTI)

    Omar, Hany A. [Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210 (United States); Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Arafa, El-Shaimaa A. [Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Salama, Samir A. [Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11511 (Egypt); Arab, Hany H. [Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562 (Egypt); Wu, Chieh-Hsi, E-mail: chhswu@mail.cmu.edu.tw [School of Pharmacy, China Medical University, Taichung 40402, Taiwan (China); Weng, Jing-Ru, E-mail: columnster@gmail.com [Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan (China)

    2013-11-01T23:59:59.000Z

    Since the introduction of angiogenesis as a useful target for cancer therapy, few agents have been approved for clinical use due to the rapid development of resistance. This problem can be minimized by simultaneous targeting of multiple angiogenesis signaling pathways, a potential strategy in cancer management known as polypharmacology. The current study aimed at exploring the anti-angiogenic activity of OSU-A9, an indole-3-carbinol-derived pleotropic agent that targets mainly Akt–nuclear factor-kappa B (NF-?B) signaling which regulates many key players of angiogenesis such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Human umbilical vein endothelial cells (HUVECs) were used to study the in vitro anti-angiogenic effect of OSU-A9 on several key steps of angiogenesis. Results showed that OSU-A9 effectively inhibited cell proliferation and induced apoptosis and cell cycle arrest in HUVECs. Besides, OSU-A9 inhibited angiogenesis as evidenced by abrogation of migration/invasion and Matrigel tube formation in HUVECs and attenuation of the in vivo neovascularization in the chicken chorioallantoic membrane assay. Mechanistically, Western blot, RT-PCR and ELISA analyses showed the ability of OSU-A9 to inhibit MMP-2 production and VEGF expression induced by hypoxia or phorbol-12-myristyl-13-acetate. Furthermore, dual inhibition of Akt–NF-?B and mitogen-activated protein kinase (MAPK) signaling, the key regulators of angiogenesis, was observed. Together, the current study highlights evidences for the promising anti-angiogenic activity of OSU-A9, at least in part through the inhibition of Akt–NF-?B and MAPK signaling and their consequent inhibition of VEGF and MMP-2. These findings support OSU-A9's clinical promise as a component of anticancer therapy. - Highlights: • The antiangiogenic activity of OSU-A9 in HUVECs was explored. • OSU-A9 inhibited HUVECs proliferation, migration, invasion and tube formation. • OSU-A9 targeted signaling pathways mediated by Akt-NF-kB, VEGF, and MMP-2. • The anti-angiogenic activity of OSU-A9 supports its clinical promise.

  5. Introduction The NF-B/Rel family of transcription factors is composed of

    E-Print Network [OSTI]

    Arnold, Jonathan

    gene expression exhibited a requirement for the host IKK complex. A detailed kinetic analysis of NF- B expression of anti-apoptotic genes and prevent death of infected cells in order to allow replication in a loss of the anti-apoptotic phenotype and a decrease in pro-survival gene expression (Molestina et al

  6. Single-cell NF-kB dynamics reveal digital activation and analogue information processing

    E-Print Network [OSTI]

    Quake, Stephen R.

    LETTERS Single-cell NF-kB dynamics reveal digital activation and analogue information processing and is a digital process at the single-cell level with fewer cells responding at lower doses. Cells also encode that reproduces both the digital and analogue dynamics as well as most gene expression profiles at all measured

  7. Microstructural Evolution in Two Variants of NF709 at 1023 and 1073 K

    E-Print Network [OSTI]

    Cambridge, University of

    and that could invalidate the extrapolations of short-term creep test data, and to identify any precipitates.K.D.H. BHADESHIA The microstructural state of two grades of the creep-resistant austenitic stainless steels NF709 regarded as one of the best austenitic steels for elevated temperature applications because of its creep

  8. Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface

    SciTech Connect (OSTI)

    Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H. [China Medical University, Shenyang (China)

    2009-07-01T23:59:59.000Z

    To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

  9. Management Plan Management Plan

    E-Print Network [OSTI]

    Plan, Management Plan Page MP­ 1 #12;Management Plan water quality standards, instream flows, privateManagement Plan Management Plan "Management and restoration programs for native salmonids have communities" J. Lichatowich et al. 1998. A Conceptual Foundation for the Management of Native Salmonids

  10. Omentin inhibits TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via ERK/NF-{kappa}B pathway

    SciTech Connect (OSTI)

    Zhong, Xia, E-mail: zhongxia1977@126.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Li, Xiaonan; Liu, Fuli; Tan, Hui [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Shang, Deya, E-mail: wenhuashenghuo1@163.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)

    2012-08-24T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Black-Right-Pointing-Pointer Omentin reduces expression of ICAM-1 and VCAM-1 induced by TNF-{alpha} in HUVECs. Black-Right-Pointing-Pointer Omentin inhibits TNF-{alpha}-induced ERK and NF-{kappa}B activation in HUVECs. Black-Right-Pointing-Pointer Omentin supreeses TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 via ERK/NF-{kappa}B pathway. -- Abstract: In the present study, we investigated whether omentin affected the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in tumor necrosis factor-{alpha} (TNF-{alpha}) induced human umbilical vein endothelial cells (HUVECs). Our data showed that omentin decreased TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 in HUVECs. In addition, omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Further, we found that omentin inhibited TNF-{alpha}-activated signal pathway of nuclear factor-{kappa}B (NF-{kappa}B) by preventing NF-{kappa}B inhibitory protein (I{kappa}B{alpha}) degradation and NF-{kappa}B/DNA binding activity. Omentin pretreatment significantly inhibited TNF-{alpha}-induced ERK activity and ERK phosphorylation in HUVECs. Pretreatment with PD98059 suppressed TNF-{alpha}-induced NF-{kappa}B activity. Omentin, NF-kB inhibitor (BAY11-7082) and ERK inhibitor (PD98059) reduced the up-regulation of ICAM-1 and VCAM-1 induced by TNF-{alpha}. These results suggest that omentin may inhibit TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via blocking ERK/NF-{kappa}B pathway.

  11. $Re(A_0)$, $Re(A_2)$ and RG evolution for $N_f=3$

    E-Print Network [OSTI]

    Choi, K; Choi, Keunsu; Lee, Weonjong

    2005-01-01T23:59:59.000Z

    We present results of $Re (A_0)$ and $Re (A_2)$ calculated using HYP staggered fermions on the lattice of $16^3 \\times 64$ at $\\beta=6.0$. These results are obtained using leading order chiral perturbation in quenched QCD. Buras's original RG evolution matrix develops a removable singularity for $N_f=3$. This subtlety is resolved by finding a finite solution to RG equation and the results are presented.

  12. Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business

    SciTech Connect (OSTI)

    Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

    2011-02-01T23:59:59.000Z

    This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

  13. NF-{kappa}B suppresses HIF-1{alpha} response by competing for P300 binding

    SciTech Connect (OSTI)

    Mendonca, Daniela B.S., E-mail: daniela_mendonca@dentistry.unc.edu [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States); Mendonca, Gustavo [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil) [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States); Aragao, Francisco J.L. [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil) [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Embrapa Recursos Geneticos e Biotecnologia, Laboratorio de Introducao e Expressao de Genes, PqEB W5 Norte, 70770-900 Brasilia, DF (Brazil); Cooper, Lyndon F., E-mail: lyndon_cooper@dentistry.unc.edu [Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States)

    2011-01-28T23:59:59.000Z

    Research highlights: {yields} p65 completely blocked HIF-1{alpha} activity at the HRE on different cell lines. {yields} p65 caused minor changes in HIF-1{alpha} and HIF-1{alpha} target genes mRNA expression. {yields} p65 reduced transcription of VEGF promoter. {yields} p65 competes with HIF-1{alpha} for p300. -- Abstract: Hypoxia has emerged as a key determinant of osteogenesis. HIF-1{alpha} is the transcription factor mediating hypoxia responses that include induction of VEGF and related bone induction. Inflammatory signals antagonize bone repair via the NF-{kappa}B pathway. The present investigation explored the functional relationship of hypoxia (HIF-1{alpha} function) and inflammatory signaling (NF-{kappa}B) in stem like and osteoprogenitor cell lines. The potential interaction between HIF-1{alpha} and NF-{kappa}B signaling was explored by co-transfection studies in hFOB with p65, HIF-1{alpha} and 9x-HRE-luc or HIF-1{alpha} target genes reporter plasmids. Nuclear cross-talk was directly tested using the mammalian Gal4/VP16 two-hybrid, and confirmed by co-immunoprecipitation/western blotting assays. The results show that inflammatory stimulation (TNF-{alpha} treatment) causes a marked inhibition of HIF-1{alpha} function at the HRE in all cell lines studied. Also, co-transfection with p65 expression vector leads to reduced hVEGFp transcription after DFO-induced hypoxia. However, TNF-{alpha} treatment had little effect on HIF-1{alpha} mRNA levels. The functional interaction of Gal4-HIF-1{alpha} and VP16-p300 fusion proteins is effectively blocked by expression of p65 in a dose dependent manner. It was concluded that NF-{kappa}B-mediated inflammatory signaling is able to block HIF-1{alpha} transactivation at HRE-encoding genes by direct competition for p300 binding at the promoter. Inflammation may influence the stem cell niche and tissue regeneration by influencing cellular responses to hypoxia.

  14. IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogen andHypernuclei in Hall CInbydoeCELLIDRMSIDS-NF

  15. FY13 Summary Report on the Augmentation of the Spent Fuel Composition Dataset for Nuclear Forensics: SFCOMPO/NF

    SciTech Connect (OSTI)

    Brady Raap, Michaele C.; Lyons, Jennifer A.; Collins, Brian A.; Livingston, James V.

    2014-03-31T23:59:59.000Z

    This report documents the FY13 efforts to enhance a dataset of spent nuclear fuel isotopic composition data for use in developing intrinsic signatures for nuclear forensics. A review and collection of data from the open literature was performed in FY10. In FY11, the Spent Fuel COMPOsition (SFCOMPO) excel-based dataset for nuclear forensics (NF), SFCOMPO/NF was established and measured data for graphite production reactors, Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs) were added to the dataset and expanded to include a consistent set of data simulated by calculations. A test was performed to determine whether the SFCOMPO/NF dataset will be useful for the analysis and identification of reactor types from isotopic ratios observed in interdicted samples.

  16. ABD56 causes osteoclast apoptosis by inhibiting the NF{kappa}B and ERK pathways

    SciTech Connect (OSTI)

    Idris, Aymen [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Mrak, Emanuela [Bone Metabolic Unit, Scientific Institute H San Raffaele, via Olgettina 60, 20132 Milano (Italy); Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Greig, Iain [Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD (United Kingdom); Guidobono, Francesca [Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Ralston, Stuart H. [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Hof, Rob van 't [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom)], E-mail: rvanthof@staffmail.ed.ac.uk

    2008-06-20T23:59:59.000Z

    We have previously shown that the biphenylcarboxylic acid butanediol ester (ABD56) inhibits osteoclast formation and activity in vitro and in vivo. However, the mechanism of action of this compound is unknown. ABD56 inhibited osteoclast formation and caused osteoclast apoptosis, but had no effects on osteoblasts or macrophages. As the NF{kappa}B and MAPK pathways are essential for osteoclast formation and survival, we studied the effects of ABD56 on these pathways. ABD56 caused phosphorylation of p38, JNK and nuclear translocation of c-jun in osteoclasts. ABD56-induced apoptosis was prevented by the caspase inhibitor zVAD-fmk but was not prevented by the p38- or JNK-inhibitors. ABD56 completely abolished RANKL-induced I{kappa}B and ERK1/2 phosphorylation. Increasing the amount of RANKL partially rescued ABD56-induced apoptosis, indicating that the apoptosis is most probably due to the inhibition of survival signals such as ERK and NF{kappa}B, rather than activation of the p38 or Jnk MAPK pathways.

  17. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-{kappa}B in hepatoma cells

    SciTech Connect (OSTI)

    Zhao, Yu [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China)] [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China); Wang, Wenhui [Department of Interventional Radiography, First Hospital of Lanzhou University, No.1 Donggang West Road, Lanzhou, Gansu Province 730000 (China)] [Department of Interventional Radiography, First Hospital of Lanzhou University, No.1 Donggang West Road, Lanzhou, Gansu Province 730000 (China); Wang, Qi [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)] [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)] [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China); Ye, Lihong, E-mail: yelihong@nankai.edu.cn [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China)] [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China)

    2012-02-24T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer 5-LOX is able to upregulate expression of NF-{kappa}B p65. Black-Right-Pointing-Pointer 5-LOX enhances nuclear translocation of NF-{kappa}B p65 via increasing p-I{kappa}B-{alpha} level. Black-Right-Pointing-Pointer 5-LOX stimulates transcriptional activity of NF-{kappa}B in hepatoma cells. Black-Right-Pointing-Pointer LTB4 activates transcriptional activity of NF-{kappa}B in hepatoma cells. -- Abstract: The issue that lipid metabolism enzyme and its metabolites regulate transcription factors in cancer cell is not fully understood. In this study, we first report that the lipid metabolism enzyme 5-Lipoxygenase (5-LOX) and its metabolite leukotriene B4 (LTB4) are capable of activating nuclear factor-{kappa}B (NF-{kappa}B) in hepatoma cells. We found that the treatment of MK886 (an inhibitor of 5-LOX) or knockdown of 5-LOX was able to downregulate the expression of NF-{kappa}B p65 at the mRNA level and decreased the phosphorylation level of inhibitor {kappa}B{alpha} (I{kappa}B{alpha}) in the cytoplasm of hepatoma HepG2 or H7402 cells, which resulted in the decrease of the level of nuclear NF-{kappa}B p65. These were confirmed by immunofluorescence staining in HepG2 cell. Moreover, the above treatments were able to decrease the transcriptional activity of NF-{kappa}B in the cells. The LTB4, one of metabolites of 5-LOX, is responsible for 5-LOX-activated NF-{kappa}B in a dose-dependent manner. Thus, we conclude that the lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-{kappa}B in hepatoma cells. Our finding provides new insight into the significance of lipid metabolism in activation of transcription factors in cancer.

  18. mm-Wave Op-Amps employing simple-Miller compensation, with OIP3/PDC ratios of 211 (10 dB NF) and 144 (6.0 dB NF) at 2 GHz

    E-Print Network [OSTI]

    Rodwell, Mark J. W.

    mm-Wave Op-Amps employing simple-Miller compensation, with OIP3/PDC ratios of 211 (10 dB NF/PDC ratio at fs = 2-3 GHz, compared to state-of-the-art. We address considerations important 1000 mW power dissipation PDC . This very high ratio of output-referred third-order-intercept power

  19. Modeling green fluorescent protein transcription, translation and modification as a method to obtain NF-kappaB activation profiles

    E-Print Network [OSTI]

    Laible, Allyson Marie

    2009-05-15T23:59:59.000Z

    that fluorescence increases up to 24 hours after an initial delay of approximately four hours. The fluorescence data was also used to develop a model describing significant events leading to NF-?B activation and GFP expression. In addition, a model describing...

  20. TCR and CD28 activate the transcription factor NF- B in T-cells viadistinct adaptor signaling complexes

    E-Print Network [OSTI]

    Thaker, Youg Raj; Schneider, Helga; Rudd, Christopher E.

    2014-10-23T23:59:59.000Z

    of NF-{kappa}B activation in T cells via association of the adapter proteins ADAP and CARMA1. Science 2007;316:754–8. [30] Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, et al. Phosphorylation of the CARMA1 linker...

  1. Enhancement of CD8+ T-cell memory by removal of a vaccinia virus NF-?B inhibitor

    E-Print Network [OSTI]

    Ren, Hongwei; Ferguson, Brian J.; de Motes, Carlos Maluquer; Sumner, Rebecca P.; Harman, Laura; Smith, Geoffrey L.

    2014-11-07T23:59:59.000Z

    induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells. J Virol 2006;80(17):8676-85. 63. Harte MT, Haga IR, Maloney G, et al. The poxvirus protein A52R targets Toll-like receptor signaling complexes...

  2. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-{kappa}B-mediated survival signaling

    SciTech Connect (OSTI)

    Leskinen, Markus J. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Heikkilae, Hanna M. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Speer, Mei Y. [Bioengineering Department, University of Washington, Seattle, WA 98195 (United States); Hakala, Jukka K. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Laine, Mika [Department of Medicine, Helsinki University Central Hospital and Minerva Institute for Medical Research, Helsinki (Finland); Kovanen, Petri T. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Lindstedt, Ken A. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland)]. E-mail: ken.lindstedt@wri.fi

    2006-05-01T23:59:59.000Z

    Chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (SMCs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and Akt dephosphorylation, which are necessary for cell adhesion and survival. However, the molecular mechanisms of chymase-mediated apoptosis downstream of Akt have remained elusive. Here, we show by means of RT-PCR, Western blotting, EMSA, immunocytochemistry and confocal microscopy, that chymase induces SMC apoptosis by disrupting NF-{kappa}B-mediated survival signaling. Following chymase treatment, the translocation of active NF-{kappa}B/p65 to the nucleus was partly abolished and the amount of nuclear p65 was reduced. Pretreatment of SMCs with chymase also inhibited LPS- and IL-1{beta}-induced nuclear translocation of p65. The chymase-induced degradation of p65 was mediated by active caspases. Loss of NF-{kappa}B-mediated transactivation resulted in downregulation of bcl-2 mRNA and protein expression, leading to mitochondrial swelling and release of cytochrome c. The apoptotic process involved activation of both caspase 9 and caspase 8. The results reveal that, by disrupting the NF-{kappa}B-mediated survival-signaling pathway, activated chymase-secreting mast cells can mediate apoptosis of cultured arterial SMCs. Since activated mast cells colocalize with apoptotic SMCs in vulnerable areas of human atherosclerotic plaques, they may participate in the weakening and rupture of atherosclerotic plaques.

  3. Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after

    E-Print Network [OSTI]

    Freger, Viatcheslav "Slava"

    2005-01-01T23:59:59.000Z

    to hot 20% sulfuric acid solutions for various times. Swelling and morphological changes measured Nanofiltration (NF) membranes represent a class of mem- branes with capabilities to selectively separate low- sulfone, which support an ultra-thin selective layer a few tens to a few hundred of nanometers thick

  4. D-Dbar Mixing in the Standard Model and Beyond from Nf=2 Twisted Mass QCD

    E-Print Network [OSTI]

    N. Carrasco; M. Ciuchini; P. Dimopoulos; R. Frezzotti; V. Gimenez; V. Lubicz; G. C. Rossi; F. Sanfilippo; L. Silvestrini; S. Simula; C. Tarantino

    2014-06-13T23:59:59.000Z

    We present the first unquenched lattice QCD results for the bag parameters controlling the short distance contribution to D meson oscillations in the Standard Model and beyond. We have used the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 dynamical quarks, at four lattice spacings and light meson masses in the range 280-500 MeV. Renormalization is carried out non-perturbatively with the RI-MOM method. The bag-parameter results have been used to constrain New Physics effects in D-Dbar mixing, to put a lower bound to the generic New Physics scale and to constrain off-diagonal squark mass terms for TeV-scale Supersymmetry.

  5. Kaon semileptonic vector form factor with $N_f=2+1+1$ Twisted Mass fermions

    E-Print Network [OSTI]

    Nuria Carrasco; Paolo Lami; Vittorio Lubicz; Eleonora Picca; Lorenzo Riggio; Silvano Simula; Cecilia Tarantino

    2014-10-27T23:59:59.000Z

    We investigate the vector form factor relevant for the $K_{\\ell 3}$ semileptonic decay using maximally twisted-mass fermions with 4 dynamical flavours ($N_f=2+1+1$). Our simulations feature pion masses ranging from $210$ MeV to approximately $450$ MeV and lattice spacing values as small as $0.06$fm. Our main result for the vector form factor at zero 4-momentum transfer is $f_+(0)=0.9683(65)$ where the uncertainty is both statistical and systematic. By combining our result with the experimental value of $f_+(0)|V_{us}|$ we obtain $|V_{us}|=0.2234(16)$, which satisfies the unitarity constraint of the Standard Model at the permille level.

  6. Ascorbic acid suppresses endotoxemia and NF-?B signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

    SciTech Connect (OSTI)

    Abhilash, P.A.; Harikrishnan, R.; Indira, M., E-mail: indiramadambath@gmail.com

    2014-01-15T23:59:59.000Z

    Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-?B activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKK? and the protein expressions of phospho-I?B?, NF-?B, TNF-?, TGF-?{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers ?-SMA, ?{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-?B activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKK?, which decreased the activation of NF-?B and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: • Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. • Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. • Ascorbic acid reduces endotoxemia, NF-?B activation and proinflammatory cytokines. • AA's action is by inhibition of SIBO, IKK? and alteration of intestinal permeability. • This might have led to suppression of HSCs activation and liver fibrosis.

  7. Network Management Network Management

    E-Print Network [OSTI]

    that pertain to the operation, administration, maintenance, and provisioning of networked systems · Operation deals with keeping the network up (and the service provided by the network) · Administration involvesNetwork Management Pag. 1 Network Management Andrea Bianco Telecommunication Network Group Network

  8. NF-kB activity-dependent P-selectin involved in ox-LDL-induced foam cell formation in U937 cell

    SciTech Connect (OSTI)

    Wang, Yi, E-mail: wangyi2004a@126.com [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China); Wang, Xiang; Sun, Minghui; Zhang, Zhenyu; Cao, Heng; Chen, Xiaoqing [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)

    2011-08-05T23:59:59.000Z

    Highlights: {yields} Ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. {yields} Ox-LDL induced expression of P-selectin through degradation of IkBa and augment of NF-kB activity and protein level during macrophage-derived foam cell formation. {yields} P-selectin and NF-kB may be identified as pivotal regulators of ox-LDL-induced foam cell formation. {yields} Therapy based on the inhibition of P-selectin and NF-kB may complement conventional treatments to prevent atherosclerosis. -- Abstract: Oxidized low-density lipoprotein (ox-LDL) plays a critical role in regulation of atherosclerosis. However, little is known about the role of Nuclear factor kB (NF-kB) activity-dependent P-selectin in ox-LDL-induced foam cell formation during atherosclerosis. In this study, we first investigated ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. Treatment of U937 cells with ox-LDL increased lipid accumulation as well as intracellular cholesterol content. Next, a comparative analysis of gene expression profiling using cDNA microarray and Real-time-PCR indicated that ox-LDL exposure induced, in three treated groups, an extremely marked increase in the mRNA level of P-selectin. Protein levels of P-selectin and its upstream regulators IkBa and NF-kB showed that NF-kB pathway is involved in the ox-LDL-induced foam cell formation. Finally, overexpression of NF-kB significantly accelerated, whereas, inhibition of NF-kB with siRNA remarkably attenuated ox-LDL-induced macrophage-derived foam cell formation. It was concluded that the activity of NF-kB is augmented during macrophage-derived foam cell formation. Activation of NF-kB increased, whereas, inhibition of NF-kB decreased ox-LDL-induced P-selectin expression and lipid accumulation in macrophages, suggesting ox-LDL induced expression of P-selectin through degradation of IkBa and activation of NF-kB in the regulation of foam cell formation.

  9. Thermal Reactions of Uranium Metal, UO2, U3O8, UF4, and UO2F2 with NF3 to Produce UF6

    SciTech Connect (OSTI)

    McNamara, Bruce K.; Scheele, Randall D.; Kozelisky, Anne E.; Edwards, Matthew K.

    2009-11-01T23:59:59.000Z

    he objective of this paper is to demonstrate that NF3 fluorinates uranium metal, UO2, UF4, UO3, U3O8, and UO2F2•2H2O to produce the volatile UF6 at temperatures between 100 and 500?C. Thermogravimetric reaction profiles are described that reflect changes in the uranium oxidation state and discrete chemical speciation. Differences in the onset temperatures for each system indicate that NF3-substrate interactions are important for the temperature at which NF3 reacts: U metal > UO3 > UO2 > UO2F2 > UF4 and in fact may indicate different fluorination mechanisms for these various substrates. These studies demonstrate that NF3 is a potential replacement fluorinating agent in the existing nuclear fuel cycle and in oft-proposed actinide volatility reprocessing.

  10. Nmero Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias

    E-Print Network [OSTI]

    Baia, Margarida

    Sheet1 Page 1 Número Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias 53515 Jorge Branco 55774 João 70100 Catarina Ferreira 70146 Mariana Castro 70364 Nuno Gaspar 70524 António Grego 10 2 5 70934 João.2 2 15 78167 Afonso Sarmento 13.8 8.3 7.6 2 12 78175 Carlos Martins 14.3 12.6 11 2 14 78183 Ana

  11. Sulforaphane protects against cytokine- and streptozotocin-induced {beta}-cell damage by suppressing the NF-{kappa}B pathway

    SciTech Connect (OSTI)

    Song, Mi-Young; Kim, Eun-Kyung [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Moon, Woo-Sung [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Park, Jin-Woo [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Kim, Hyung-Jin; So, Hong-Seob; Park, Raekil [Vestibulocochlear System Research Center, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of); Kwon, Kang-Beom [Department of Physiology, School of Oriental Medicine, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of); Vestibulocochlear System Research Center, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of)], E-mail: desson@wonkwang.ac.kr; Park, Byung-Hyun [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of)], E-mail: bhpark@chonbuk.ac.kr

    2009-02-15T23:59:59.000Z

    Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes. Treatment of RINm5F insulinoma cells with SFN increases Nrf2 nuclear translocation and expression of phase 2 enzymes. In this study, we investigated whether the activation of Nrf2 by SFN treatment or ectopic overexpression of Nrf2 inhibited cytokine-induced {beta}-cell damage. Treatment of RIN cells with IL-1{beta} and IFN-{gamma} induced {beta}-cell damage through a NF-{kappa}B-dependent signaling pathway. Activation of Nrf2 by treatment with SFN and induction of Nrf2 overexpression by transfection with Nrf2 prevented cytokine toxicity. The mechanism by which Nrf2 activation inhibited NF-{kappa}B-dependent cell death signals appeared to involve the reduction of oxidative stress, as demonstrated by the inhibition of cytokine-induced H{sub 2}O{sub 2} production. The protective effect of SFN was further demonstrated by the restoration of normal insulin secreting responses to glucose in cytokine-treated rat pancreatic islets. Furthermore, pretreatment with SFN blocked the development of type 1 diabetes in streptozotocin-treated mice.

  12. SUBCONTRACT MANAGEMENT

    Energy Savers [EERE]

    0-1 CHAPTER 10 SUBCONTRACT MANAGEMENT (Revised October 19, 2011) WHAT ARE THE BASIC PRINCIPLES AND OBJECTIVES OF SUBCONTRACT MANAGEMENT? 1. To ensure contractors establish,...

  13. Hospitality Management Hospitality Management

    E-Print Network [OSTI]

    McConnell, Terry

    of the Department of Hospitality Management and to the recorder in the College of Human Ecology. Required HPM 114 Food Safety and Quality Assurance 2 AND HPM 115 Food Science I 3 AND HPM 216 Restaurant and Food Service Operations 4 OR NSD 225 Nutrition in Health 3 12 credits needed: HPM 300 Selected Topics: Advanced

  14. Conference Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-11-03T23:59:59.000Z

    To establish requirements and responsibilities with respect to managing conferences sponsored by the Department of Energy (DOE) or by DOE management and operating contractors and other contractors who perform work at DOE-owned or -leased facilities, including management and integration contractors and environmental restoration management contractors (when using funds that will be reimbursed by DOE). Cancels DOE N 110.3.

  15. Etching of UO{sub 2} in NF{sub 3} RF Plasma Glow Discharge

    SciTech Connect (OSTI)

    John M. Veilleux

    1999-08-01T23:59:59.000Z

    A series of room temperature, low pressure (10.8 to 40 Pa), low power (25 to 210 W) RF plasma glow discharge experiments with UO{sub 2} were conducted to demonstrate that plasma treatment is a viable method for decontaminating UO{sub 2} from stainless steel substrates. Experiments were conducted using NF{sub 3} gas to decontaminate depleted uranium dioxide from stainless-steel substrates. Depleted UO{sub 2} samples each containing 129.4 Bq were prepared from 100 microliter solutions of uranyl nitrate hexahydrate solution. The amorphous UO{sub 2} in the samples had a relatively low density of 4.8 gm/cm{sub 3}. Counting of the depleted UO{sub 2} on the substrate following plasma immersion was performed using liquid scintillation counting with alpha/beta discrimination due to the presence of confounding beta emitting daughter products, {sup 234}Th and {sup 234}Pa. The alpha emission peak from each sample was integrated using a gaussian and first order polynomial fit to improve quantification. The uncertainties in the experimental measurement of the etched material were estimated at about {+-} 2%. Results demonstrated that UO{sub 2} can be completely removed from stainless-steel substrates after several minutes processing at under 200 W. At 180 W and 32.7 Pa gas pressure, over 99% of all UO{sub 2} in the samples was removed in just 17 minutes. The initial etch rate in the experiments ranged from 0.2 to 7.4 {micro}m/min. Etching increased with the plasma absorbed power and feed gas pressure in the range of 10.8 to 40 Pa. A different pressure effect on UO{sub 2} etching was also noted below 50 W in which etching increased up to a maximum pressure, {approximately}23 Pa, then decreased with further increases in pressure.

  16. Renormalization of local quark-bilinear operators for Nf=3 flavors of SLiNC fermions

    E-Print Network [OSTI]

    M. Constantinou; R. Horsley; H. Panagopoulos; H. Perlt; P. E. L. Rakow; G. Schierholz; A. Schiller; J. M. Zanotti

    2014-08-26T23:59:59.000Z

    The renormalization factors of local quark-bilinear operators are computed non-perturbatively for $N_f=3$ flavors of SLiNC fermions, with emphasis on the various procedures for the chiral and continuum extrapolations. The simulations are performed at a lattice spacing $a=0.074$ fm, and for five values of the pion mass in the range of 290-465 MeV, allowing a safe and stable chiral extrapolation. Emphasis is given in the subtraction of the well-known pion pole which affects the renormalization factor of the pseudoscalar current. We also compute the inverse propagator and the Green's functions of the local bilinears to one loop in perturbation theory. We investigate lattice artifacts by computing them perturbatively to second order as well as to all orders in the lattice spacing. The renormalization conditions are defined in the RI$'$-MOM scheme, for both the perturbative and non-perturbative results. The renormalization factors, obtained at different values of the renormalization scale, are translated to the ${\\bar{\\rm MS}}$ scheme and are evolved perturbatively to 2 GeV. Any residual dependence on the initial renormalization scale is eliminated by an extrapolation to the continuum limit. We also study the various sources of systematic errors. Particular care is taken in correcting the non-perturbative estimates by subtracting lattice artifacts computed to one loop perturbation theory using the same action. We test two different methods, by subtracting either the ${\\cal O}(g^2\\,a^2)$ contributions, or the complete (all orders in $a$) one-loop lattice artifacts.

  17. Determination of c_sw in N_f=3+1 Lattice QCD with massive Wilson fermions

    E-Print Network [OSTI]

    Patrick Fritzsch; Rainer Sommer; Felix Stollenwerk; Ulli Wolff

    2015-01-27T23:59:59.000Z

    We develop a strategy for the non-perturbative determination of the O(a)-improvement coefficient c_sw for Wilson fermions with massive sea quarks. The improvement condition is defined via the PCAC relation in the Schr\\"odinger functional. It is imposed along a line of constant physics designed to be close to the correct mass of the charm quark. The numerical work uses the tree-level improved L\\"uscher-Weisz gauge action in N_f=3+1 Lattice QCD.

  18. A (P)HMC algorithm for N_f = 2 + 1 + 1 flavours of twisted mass fermions

    E-Print Network [OSTI]

    T. Chiarappa; R. Frezzotti; C. Urbach

    2005-09-27T23:59:59.000Z

    We present a detailed design of a (P)HMC simulation algorithm for N_f = 2 + 1 + 1 maximally twisted Wilson quark flavours. The algorithm retains even/odd and mass-shift preconditionings combined with multiple Molecular Dynamics time scales for both the light mass degenerate, u and d, quarks and the heavy mass non-degenerate, s and c, quarks. Various non-standard aspects of the algorithm are discussed, among which those connected to the use of a polynomial approximation for the inverse (square root of the squared) Dirac matrix in the s and c quark sector.

  19. Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB

    E-Print Network [OSTI]

    Dai, Yao; Jeffrey, Tang; Wenhua, Xiaojie; Meng, Yang; Burstein, Ezra; Lawrence, Theodore S.; Xu, Liang

    2010-12-10T23:59:59.000Z

    Apoptotic Proteins and NF-kappaB. PLoS ONE 5(12): e14153. doi:10.1371/journal.pone.0014153 Editor: Gen Sheng Wu, Wayne State University, United States of America Received July 10, 2010; Accepted November 10, 2010; Published December 10, 2010 Copyright: #2... through a University of Michigan Cancer Center Support Grant [5 P30 CA46592]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared...

  20. Project Management Plan Resident Management System (RMS)

    E-Print Network [OSTI]

    US Army Corps of Engineers

    1 Project Management Plan Resident Management System (RMS) And Quality Control System (QCS Resident Management System.........................................................................................................3 Project Management Plan - Purpose

  1. NF-{kappa}B signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells

    SciTech Connect (OSTI)

    Sakuma, Yuji, E-mail: ysakuma@gancen.asahi.yokohama.jp [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)] [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan); Yamazaki, Yukiko; Nakamura, Yoshiyasu; Yoshihara, Mitsuyo; Matsukuma, Shoichi; Koizume, Shiro; Miyagi, Yohei [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)] [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)

    2012-07-13T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer EGFR-mutant cells in 3D culture resist EGFR inhibition compared with suspended cells. Black-Right-Pointing-Pointer Degradation of I{kappa}B and activation of NF-{kappa}B are observed in 3D-cultured cells. Black-Right-Pointing-Pointer Inhibiting NF-{kappa}B enhances the efficacy of the EGFR inhibitor in 3D-cultured cells. -- Abstract: Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma cells in suspension undergo apoptosis to a greater extent than adherent cells in a monolayer when EGFR autophosphorylation is inhibited by EGFR tyrosine kinase inhibitors (TKIs). This suggests that cell adhesion to a culture dish may activate an anti-apoptotic signaling pathway other than the EGFR pathway. Since the microenvironment of cells cultured in a monolayer are substantially different to that of cells existing in three-dimension (3D) in vivo, we assessed whether two EGFR-mutant lung adenocarcinoma cell lines, HCC827 and H1975, were more resistant to EGFR TKI-induced apoptosis when cultured in a 3D extracellular matrix (ECM) as compared with in suspension. The ECM-adherent EGFR-mutant cells in 3D were significantly less sensitive to treatment with WZ4002, an EGFR TKI, than the suspended cells. Further, a marked degradation of I{kappa}B{alpha}, the inhibitor of nuclear factor (NF)-{kappa}B, was observed only in the 3D-cultured cells, leading to an increase in the activation of NF-{kappa}B. Moreover, the inhibition of NF-{kappa}B with pharmacological inhibitors enhanced EGFR TKI-induced apoptosis in 3D-cultured EGFR-mutant cells. These results suggest that inhibition of NF-{kappa}B signaling would render ECM-adherent EGFR-mutant lung adenocarcinoma cells in vivo more susceptible to EGFR TKI-induced cell death.

  2. Determination of the running coupling constant $?_s$ for Nf=2+1 QCD with the Schroedinger functional scheme

    E-Print Network [OSTI]

    Yusuke Taniguchi; for the PACS-CS collaboration

    2009-10-27T23:59:59.000Z

    We present an evaluation of the running coupling constant and the quark mass renormalization factor for $N_f=2+1$ QCD. The Schr\\"odinger functional scheme is used as the intermediate scheme to carry out non-perturbative running from the low energy region, where physical input is introduced, to deep in the high energy perturbative region, where conversion to the ${\\ovl{\\rm MS}}$ scheme is safely performed. For numerical simulations we adopted Iwasaki gauge action and non-perturbatively improved Wilson fermion action with the clover term. Seven renormalization scales are used to cover from low to high energy region and three lattice spacings to take the continuum limit at each scale. Physical inputs are introduced from the previous $N_f=2+1$ simulation of the CP-PACS/JL-QCD collaboration, which covered the up-down quark mass range heavier than $m_\\pi\\sim 500$ MeV, and that of PACS-CS collaboration for much lighter quark masses down to $m_\\pi=155$ MeV.

  3. Angiotensin II modulates interleukin-1{beta}-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-{kappa}B crosstalk

    SciTech Connect (OSTI)

    Xu, Shanqin [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Zhi, Hui [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)] [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States); Hou, Xiuyun [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Jiang, Bingbing, E-mail: bjiang1@rics.bwh.harvard.edu [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States) [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)

    2011-07-08T23:59:59.000Z

    Highlights: {yields} We examine how angiotensin II modulates ERK-NF-{kappa}B crosstalk and gene expression. {yields} Angiotensin II suppresses IL-1{beta}-induced prolonged ERK and NF-{kappa}B activation. {yields} ERK-RSK1 signaling is required for IL-1{beta}-induced prolonged NF-{kappa}B activation. {yields} Angiotensin II modulates NF-{kappa}B responsive genes via regulating ERK-NF-{kappa}B crosstalk. {yields} ERK-NF-{kappa}B crosstalk is a novel mechanism regulating inflammatory gene expression. -- Abstract: Angiotensin II is implicated in cardiovascular diseases, which is associated with a role in increasing vascular inflammation. The present study investigated how angiotensin II modulates vascular inflammatory signaling and expression of inducible nitric oxide synthase (iNOS) and vascular cell adhesion molecule (VCAM)-1. In cultured rat aortic vascular smooth muscle cells (VSMCs), angiotensin II suppressed interleukin-1{beta}-induced prolonged phosphorylation of extracellular signal-regulated kinase (ERK) and ribosomal S6 kinase (RSK)-1, and nuclear translocation of nuclear factor (NF)-{kappa}B, leading to decreased iNOS but enhanced VCAM-1 expression, associated with an up-regulation of mitogen-activated protein kinase phosphatase-1 expression. Knock-down of RSK1 selectively down regulated interleukin-1{beta}-induced iNOS expression without influencing VCAM-1 expression. In vivo experiments showed that interleukin-1{beta}, iNOS, and VCAM-1 expression were detectable in the aortic arches of both wild-type and apolipoprotein E-deficient (ApoE{sup -/-}) mice. VCAM-1 and iNOS expression were higher in ApoE{sup -/-} than in wild type mouse aortic arches. Angiotensin II infusion (3.2 mg/kg/day, for 6 days, via subcutaneous osmotic pump) in ApoE{sup -/-} mice enhanced endothelial and adventitial VCAM-1 and iNOS expression, but reduced medial smooth muscle iNOS expression associated with reduced phosphorylation of ERK and RSK-1. These results indicate that angiotensin II can differentially modulate inflammatory gene expression in aortic smooth muscle cells through influencing ERK-NF-{kappa}B crosstalk, which may contribute to angiotensin II-induced inflammatory disorders related to cardiovascular diseases.

  4. Apolipoprotein E inhibits osteoclast differentiation via regulation of c-Fos, NFATc1 and NF-?B

    SciTech Connect (OSTI)

    Kim, Woo-Shin; Kim, Hyung Joon; Lee, Zang Hee [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of); Lee, Youngkyun [Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu 700-422 (Korea, Republic of); Kim, Hong-Hee, E-mail: hhbkim@snu.ac.kr [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of)

    2013-02-15T23:59:59.000Z

    Apolipoprotein E (ApoE) plays a major role in the transport and metabolism of lipid. Other functions of ApoE include modulation of innate and adaptive immune responses. The expression of ApoE in osteoblasts and its relevance with bone formation have also been reported. However, the effect of ApoE on osteoclasts has not yet been examined. Here, we investigated the role of ApoE in osteoclast differentiation using bone marrow-derived macrophages (BMMs) and RAW264.7 cells. We found a down-regulation of ApoE gene expression during osteoclastic differentiation of those cells. Overexpression of ApoE in BMMs and RAW264.7 cells significantly blocked the induction of c-Fos and nuclear factor of activated T cell c1 (NFATc1), transcription factors critical for expression of osteoclast marker genes, by receptor activator of nuclear factor ?B ligand (RANKL), the osteoclast differentiation factor. ApoE inhibited osteoclast differentiation, as measured by decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells (MNCs). In addition, ApoE reduced the expression of dendritic cell-specific transmembrane protein (DC-STAMP) and ATPase, H{sup +} transporting, lysosomal 38 kDa, V0 subunit d2 (ATP6v0d2), genes involved in cell–cell fusion during osteoclastogenesis. Knock-down of ApoE using a specific siRNA promoted the RANKL-mediated induction of osteoclast differentiation. While ApoE did not affect the activation of ERK, JNK, and p38 MAPK signaling pathways by RANKL, the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were reduced by ApoE overexpression. These findings suggest that ApoE plays an inhibitory role in osteoclast differentiation via the suppression of RANKL-dependent activation of NF-?B and induction of c-Fos and NFATc1. - Highlights: ? Apolipoprotein E (ApoE) significantly inhibited osteoclast differentiation and activation of NF-?B. ? ApoE decreased the induction of osteoclast marker genes such as c-Fos, NFATc1, TRAP, DC-STAMP and Cathepsin K. ? ApoE reduced number of TRAP-positive multinuclear cells. ? Exogenous ApoE inhibits osteoclast formation by reduction of crucial factor of osteoclast differentiation. ? knock-down of ApoE promoted the RANKL-mediated induction of osteoclast differentiation.

  5. GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF-B ACTIVATION AND NITRIC OXIDE PRODUCTION*

    E-Print Network [OSTI]

    Nicchitta, Chris

    GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF- B signaling and ni- tric oxide production, as well as the MAP kinase p38, JNK, and ERK signaling cascades a marked increase in ERK phosphorylation at protein concentrations as low as 2 g/ml. These results

  6. Differential Effects of ?-catenin and NF-?B Interplay in the Regulation of Cell Proliferation, Inflammation and Tumorigenesis in Response to Bacterial Infection

    E-Print Network [OSTI]

    Chandrakesan, Parthasarathy; Jakkula, Laxmi Uma Maheswar Rao; Ahmed, Ishfaq; Roy, Badal; Anant, Shrikant; Umar, Shahid

    2013-11-21T23:59:59.000Z

    Both ?-catenin and NF-?B have been implicated in our laboratory as candidate factors in driving proliferation in an in vivo model of Citrobacter rodentium (CR)-induced colonic crypt hyper-proliferation and hyperplasia. Herein, we test the hypothesis...

  7. Position Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1992-06-23T23:59:59.000Z

    The order prescribes the policies, responsibilities, and procedures for position management within (DOE). Canceled by DOE N 1321.140. Cancels DOE 3510.1

  8. Management Analyst

    Broader source: Energy.gov [DOE]

    The Wind and Water Power Technologies Office (WWPTO) manages efforts to improve performance, lower costs, and accelerate deployment of wind and water power technologies, which can play a...

  9. Quality Management

    Broader source: Energy.gov [DOE]

    The Office of Quality Management, within the Office of Health, Safety and Security develops policies and procedures to ensure the classification and control of information is effective and...

  10. Spontaneous transition of core radial electric field driven by magnetic islands in the H-1NF heliac

    SciTech Connect (OSTI)

    Kumar, S. T. A. [University of Wisconsin, Madison; Blackwell, B. D. [Australian National University, Canberra, Australia; Howard, J. [Australian National University, Canberra, Australia; Harris, J. H. [Oak Ridge National Laboratory (ORNL)

    2011-01-01T23:59:59.000Z

    This paper reports an experimental observation of spontaneous transition of the core radial electric field to a large positive value (E(r) similar to 5 kV m(-1)), with a strong electric-field shear (similar to 700 kV m(-2)) in a low temperature (T(e) similar to 10 eV) radio frequency generated argon plasma in the H-1NF heliac stellarator. The transition, which seems to be driven by a spontaneous excitation of m = 2 magnetic islands near the core, is associated with a localized increase in the plasma density and excitation of coherent low frequency (similar to 3 kHz) oscillations possibly due to unstable E(r) shear driven modes. Evidence suggests development of the core electron-root scenario, which previously has been observed only at high temperature electron cyclotron heated plasmas.

  11. Absolute frequency measurements of 85Rb nF7/2 Rydberg states using purely optical detection

    E-Print Network [OSTI]

    L. A. M. Johnson; H. O. Majeed; B. Sanguinetti; Th. Becker; B. T. H. Varcoe

    2010-02-16T23:59:59.000Z

    A three-step laser excitation scheme is used to make absolute frequency measurements of highly excited nF7/2 Rydberg states in 85Rb for principal quantum numbers n=33-100. This work demonstrates the first absolute frequency measurements of rubidium Rydberg levels using a purely optical detection scheme. The Rydberg states are excited in a heated Rb vapour cell and Doppler free signals are detected via purely optical means. All of the frequency measurements are made using a wavemeter which is calibrated against a GPS disciplined self-referenced optical frequency comb. We find that the measured levels have a very high frequency stability, and are especially robust to electric fields. The apparatus has allowed measurements of the states to an accuracy of 8.0MHz. The new measurements are analysed by extracting the modified Rydberg-Ritz series parameters.

  12. Magnetic susceptibility and equation of state of N_f = 2+1 QCD with physical quark masses

    E-Print Network [OSTI]

    Claudio Bonati; Massimo D'Elia; Marco Mariti; Francesco Negro; Francesco Sanfilippo

    2014-05-13T23:59:59.000Z

    We determine the free energy of strongly interacting matter as a function of an applied constant and uniform magnetic field. We consider N_f = 2+1 QCD with physical quark masses, discretized on a lattice by stout improved staggered fermions and a tree level improved Symanzik pure gauge action, and explore three different lattice spacings. For magnetic fields of the order of those produced in non-central heavy ion collisions (eB ~ 0.1 GeV^2) strongly interacting matter behaves like a medium with a linear response, and is paramagnetic both above and below the deconfinement transition, with a susceptibility which steeply rises in the deconfined phase. We compute the equation of state, showing that the relative increase in the pressure due to the magnetic field gets larger around the transition, and of the order of 10 % for eB ~ 0.1 GeV^2.

  13. Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-{kappa}B pathway, and MMP-9 expression

    SciTech Connect (OSTI)

    Kang, Myoung Hee [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Oh, Sang Cheul [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Lee, Hyun Joo [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kang, Han Na; Kim, Jung Lim [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kim, Jun Suk [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Yoo, Young A., E-mail: ydanbi@korea.ac.kr [Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)

    2011-07-15T23:59:59.000Z

    Bone morphogenetic proteins (BMPs) have been implicated in tumorigenesis and metastatic progression in various types of cancer cells, but the role and cellular mechanism in the invasive phenotype of gastric cancer cells is not known. Herein, we determined the roles of phosphoinositide 3-kinase (PI3K)/AKT, extracellular signal-regulated protein kinase (ERK), nuclear factor (NF)-{kappa}B, and matrix metalloproteinase (MMP) expression in BMP-2-mediated metastatic function in gastric cancer. We found that stimulation of BMP-2 in gastric cancer cells enhanced the phosphorylation of AKT and ERK. Accompanying activation of AKT and ERK kinase, BMP-2 also enhanced phosphorylation/degradation of I{kappa}B{alpha} and the nuclear translocation/activation of NF-{kappa}B. Interestingly, blockade of PI3K/AKT and ERK signaling using LY294002 and PD98059, respectively, significantly inhibited BMP-2-induced motility and invasiveness in association with the activation of NF-{kappa}B. Furthermore, BMP-2-induced MMP-9 expression and enzymatic activity was also significantly blocked by treatment with PI3K/AKT, ERK, or NF-{kappa}B inhibitors. Immunohistochemistry staining of 178 gastric tumor biopsies indicated that expression of BMP-2 and MMP-9 had a significant positive correlation with lymph node metastasis and a poor prognosis. These results indicate that the BMP-2 signaling pathway enhances tumor metastasis in gastric cancer by sequential activation of the PI3K/AKT or MAPK pathway followed by the induction of NF-{kappa}B and MMP-9 activity, indicating that BMP-2 has the potential to be a therapeutic molecular target to decrease metastasis.

  14. Enterprise Risk Management Program

    E-Print Network [OSTI]

    Hayden, Nancy J.

    Enterprise Risk Management Program DRAFT Introduction to Enterprise Risk Management at UVM 1 #12;Enterprise Risk Management Program DRAFT What is Enterprise Risk Management? Enterprise risk management governance, and accountability · Facilitates effective management of the uncertainty and associated risks

  15. Conference Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-01-25T23:59:59.000Z

    The Order establishes requirements and responsibilities for managing conferences sponsored or co-sponsored by the Department of Energy, including the National Nuclear Security Administration. Cancels DOE O 110.3. Canceled by DOE N 251.97.

  16. Project Manager

    Broader source: Energy.gov [DOE]

    A successful candidate in this position will serve as a project manager in the Fuel Cell Technologies Office in the DOE-EERE Office of Transportation responsible for a wide variety of highly...

  17. Management Analyst

    Broader source: Energy.gov [DOE]

    The incumbent in this position will serve as a Management Analyst in the Strategy Execution group of the Corporate Strategy organization (SE). The Strategy Execution group develops and coordinates...

  18. Managing Solutions

    E-Print Network [OSTI]

    Baker, Emily

    2007-01-01T23:59:59.000Z

    , and Texas Water --------------------------------------------- Project Managers Cecilia Wagner, Kevin Wagner, Danielle Supercinski, Dr. Bill Fox and Lucas Gregory work to link university researchers and Extension specialists to appropriate funding agen... Irrigators Network. Kevin Wagner, who joined TWRI in 2005 from TSSWCB, has spent several years working with environmental issues. He is currently pursuing his doctorate evaluating best management practices for reducing bacterial runoff from cattle wastes...

  19. Business Management Analyst Business Manager Director of Communication Contracts Manager

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    · Business Management Analyst · Business Manager · Director of Communication · Contracts Manager of Sales · President/Owner · Instructor of Business · Senior Buyer · North American Sales Manager · Talent graduation. You will have the skills & knowledge to manage and grow a successful business. You will be able

  20. Inhibition of inflammatory mediators contributes to the anti-inflammatory activity of KYKZL-1 via MAPK and NF-?B pathway

    SciTech Connect (OSTI)

    Xu, Guang-Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Department of Pharmacology, University of Michigan, Ann Arbor (United States); Du, Yi-Fang; Cheng, Jing; Huan, Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Chen, Shi-Cui [Jinhu Food and Drug Administration, Jiangsu (China); Wei, Shao-Hua [College of Chemistry and Materials Science, Nanjing Normal University, Nanjing (China); Gong, Zhu-Nan, E-mail: biopharmacology@126.com [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Cai, Jie; Qiu, Ting; Wu, Hao; Sun, Ting [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Ao, Gui-Zhen [Department of Medicinal Chemistry, School of Pharmacy, Soochow University, Jiangsu (China)

    2013-10-01T23:59:59.000Z

    KYKZL-1, a newly synthesized compound with COX/5-LOX dual inhibition, was subjected to the anti-inflammatory activity test focusing on its modulation of inflammatory mediators as well as intracellular MAPK and NF-?B signaling pathways. In acute ear edema model, pretreatment with KYKZL-1 (p.o.) dose-dependently inhibited the xylene-induced ear edema in mice with a higher inhibition than diclofenac. In a three-day TPA-induced inflammation, KYKZL-1 also showed significant anti-inflammatory activity with inhibition ranging between 20% and 64%. In gastric lesion test, KYKZL-1 elicited markedly fewer stomach lesions with a low index of ulcer as compared to diclofenac in rats. In further studies, KYKZL-1 was found to significantly inhibit the production of NO, PGE{sub 2}, LTB{sub 4} in LPS challenged RAW264.7, which is parallel to its attenuation of the expression of iNOS, COX-2, 5-LOX mRNAs or proteins and inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. Taken together, our data indicate that KYKZL-1 comprises dual inhibition of COX and 5-LOX and exerts an obvious anti-inflammatory activity with an enhanced gastric safety profile via simultaneous inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. - Highlights: • KYKZL-1 is designed to exhibit COX/5-LOX dual inhibition. • KYKZL-1 inhibits NO, PGE{sub 2} and LTB{sub 4} and iNOS, COX-2 and 5-LOX mRNAs and MAPKs. • KYKZL-1 inhibits phosphorylation of MAPKs. • KYKZL-1 inactivates NF-?B pathway.

  1. Carbachol ameliorates lipopolysaccharide-induced intestinal epithelial tight junction damage by down-regulating NF-{kappa}{beta} and myosin light-chain kinase pathways

    SciTech Connect (OSTI)

    Zhang, Ying [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China); Li, Jianguo, E-mail: 2010lijianguo@sina.cn [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)

    2012-11-16T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Carbachol reduced the lipopolysaccharide-induced intestinal barrier breakdown. Black-Right-Pointing-Pointer Carbachol ameliorated the lipopolysaccharide-induced ileal tight junction damage. Black-Right-Pointing-Pointer Carbachol prevented the LPS-induced NF-{kappa}{beta} and myosin light-chain kinase activation. Black-Right-Pointing-Pointer Carbachol exerted its beneficial effects in an {alpha}7 nicotinic receptor-dependent manner. -- Abstract: Carbachol is a cholinergic agonist that protects the intestines after trauma or burn injury. The present study determines the beneficial effects of carbachol and the mechanisms by which it ameliorates the lipopolysaccharide (LPS)-induced intestinal barrier breakdown. Rats were injected intraperitoneally with 10 mg/kg LPS. Results showed that the gut barrier permeability was reduced, the ultrastructural disruption of tight junctions (TJs) was prevented, the redistribution of zonula occludens-1 and claudin-2 proteins was partially reversed, and the nuclear factor-kappa beta (NF-{kappa}{beta}) and myosin light-chain kinase (MLCK) activation in the intestinal epithelium were suppressed after carbachol administration in LPS-exposed rats. Pretreatment with the {alpha}7 nicotinic acetylcholine receptor ({alpha}7nAchR) antagonist {alpha}-bungarotoxin blocked the protective action of carbachol. These results suggested that carbachol treatment can protect LPS-induced intestinal barrier dysfunction. Carbachol exerts its beneficial effect on the amelioration of the TJ damage by inhibiting the NF-{kappa}{beta} and MLCK pathways in an {alpha}7nAchR-dependent manner.

  2. Broken Valence Chiral Symmetry and Chiral Polarization of Dirac Spectrum in N$_f$=12 QCD at Small Quark Mass

    E-Print Network [OSTI]

    Andrei Alexandru; Ivan Horváth

    2014-12-04T23:59:59.000Z

    The validity of recently proposed equivalence between valence spontaneous chiral symmetry breaking (vSChSB) and chiral polarization of low energy Dirac spectrum (ChP) in SU(3) gauge theory, is examined for the case of twelve mass-degenerate fundamental quark flavors. We find that the vSChSB-ChP correspondence holds for regularized systems studied. Moreover, our results suggest that vSChSB occurs in two qualitatively different circumstances: there is a quark mass $m_c$ such that for $m > m_c$ the mode condensing Dirac spectrum exhibits standard monotonically increasing density, while for $m_{ch} < m < m_c$ the peak around zero separates from the bulk of the spectrum, with density showing a pronounced depletion at intermediate scales. Valence chiral symmetry restoration may occur at yet smaller masses $m < m_{ch}$, but this has not yet been seen by overlap valence probe, leaving the $m_{ch}=0$ possibility open. The latter option could place massless N$_f$=12 theory outside of conformal window. Anomalous behavior of overlap Dirac spectrum for $m_{ch} < m < m_c$ is qualitatively similar to one observed previously in zero and few-flavor theories as an effect of thermal agitation.

  3. Up, down, strange and charm quark masses with Nf = 2+1+1 twisted mass lattice QCD

    E-Print Network [OSTI]

    N. Carrasco; A. Deuzeman; P. Dimopoulos; R. Frezzotti; V. Gimenez; G. Herdoiza; P. Lami; V. Lubicz; D. Palao; E. Picca; S. Recker; L. Riggio; G. C. Rossi; F. Sanfilippo; L. Scorzato; S. Simula; C. Tarantino; C. Urbach; U. Wenger

    2014-08-21T23:59:59.000Z

    We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210 - 450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI-MOM method. The results for the quark masses converted to the bar{MS} scheme are: mud(2 GeV) = 3.70(17) MeV, ms(2 GeV) = 99.6(4.3) MeV and mc(mc) = 1.348(46) GeV. We obtain also the quark mass ratios ms/mud = 26.66(32) and mc/ms = 11.62(16). By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate mu/md = 0.470(56), leading to mu = 2.36(24) MeV and md = 5.03(26) MeV.

  4. Risk Management Policy Category: Strategic Management

    E-Print Network [OSTI]

    1 Risk Management Policy Category: Strategic Management 1. PURPOSE To support the University will be encouraged to speak openly and honestly. (iii) Managers will monitor risk and will disclose risks identified's risk appetite. 2.3. Risk management standards 2.3.1 The University's risk management framework

  5. Environmental Management System Plan

    E-Print Network [OSTI]

    Fox, Robert

    2009-01-01T23:59:59.000Z

    Management Program, R-3 • Environmental Management SystemEnvironmental policy 3. Environmental aspects 4. Legal andObjectives, targets, and Environmental Management Programs

  6. Data Management Policy | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Data Management Policy Data Management Policy The data management resource information and data release policies below are provided to help researchers understand the data...

  7. NERSC Data Management Policies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Data Management Policies NERSC Data Management Policies Introduction NERSC provides its users with the means to store, manage, and share their research data products. In addition...

  8. Riparian Area. . . . . . . . . . . . . . . . . . . . Management Handbook

    E-Print Network [OSTI]

    Balasundaram, Balabhaskar "Baski"

    ..............................................................................................................19 Bruce Hoagland, Oklahoma Biological Survey and the University of Oklahoma Forest Management Riparian Area. . . . . . . . . . . . . . . . . . . . Management Handbook E-952 Oklahoma Cooperative . . . . . . . . . . . . . Oklahoma Conservation Commission Management Handbook #12

  9. Office of Legacy Management FY 2009 Energy Management Data Report...

    Office of Environmental Management (EM)

    Office of Legacy Management FY 2009 Energy Management Data Report Office of Legacy Management FY 2009 Energy Management Data Report FY 2009 Energy Management Performance Summary...

  10. MUSHROOM WASTE MANAGEMENT PROJECT LIQUID WASTE MANAGEMENT

    E-Print Network [OSTI]

    of solid and liquid wastes generated at mushroom producing facilities. Environmental guidelines#12;MUSHROOM WASTE MANAGEMENT PROJECT LIQUID WASTE MANAGEMENT PHASE I: AUDIT OF CURRENT PRACTICE The Mushroom Waste Management Project (MWMP) was initiated by Environment Canada, the BC Ministry

  11. MATERIALS MANAGEMENT MATERIALS MANAGEMENT -INVENTORY CONTROL

    E-Print Network [OSTI]

    Oliver, Douglas L.

    MATERIALS MANAGEMENT MATERIALS MANAGEMENT - INVENTORY CONTROL Record of Property Transferred from ______ ___________________________________ 2. DEAN (If Applies) ______ ___________________________________ 5. UNIVERSITY DIRECTOR OF MATERIALS MANAGEMENT ______ ___________________________________ 3. HOSPITAL DIRECTOR (If Applies) ______ IF YOU NEED

  12. Managing Critical Management Improvement Initiatives

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-10-01T23:59:59.000Z

    Provides requirements and responsibilities for planning, executing and assessing critical management improvement initiatives within DOE. DOE N 251.59, dated 9/27/2004, extends this Notice until 10/01/2005. Archived 11-8-10. Does not cancel other directives.

  13. Rosiglitazone attenuates NF-{kappa}B-dependent ICAM-1 and TNF-{alpha} production caused by homocysteine via inhibiting ERK{sub 1/2}/p38MAPK activation

    SciTech Connect (OSTI)

    Bai, Yong-Ping [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Liu, Yu-Hui [Department of Pharmacology, College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006 (China); Chen, Jia [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Song, Tao [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); You, Yu [Department of Digestive Medicine, Xiangya Second Hospital, Central South University, Changsha, Hunan 410078 (China); Tang, Zhen-Yan [Department of Urologic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Li, Yuan-Jian [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); Zhang, Guo-Gang [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China)]. E-mail: xyzgg2006@sina.com

    2007-08-17T23:59:59.000Z

    Previous studies demonstrated an important interaction between nuclear factor-kappaB (NF-{kappa}B) activation and homocysteine (Hcy)-induced cytokines expression in endothelial cells and vascular smooth muscle cells. However, the underlying mechanism remains illusive. In this study, we investigated the effects of Hcy on NF-{kappa}B-mediated sICAM-1, TNF-{alpha} production and the possible involvement of ERK{sub 1/2}/p38MAPK pathway. The effects of rosiglitazone intervention were also examined. Our results show that Hcy increased the levels of sICAM-1 and TNF-{alpha} in cultured human umbilical vein endothelial cells (HUVECs) in a time- and concentration-dependent manner. This effect was significantly depressed by rosiglitazone and different inhibitors (PDTC, NF-{kappa}B inhibitor; PD98059, MEK inhibitor; SB203580, p38MAPK specific inhibitor; and staurosporine, PKC inhibitor). Next, we investigated the effect of Hcy on ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B activity in HUVECs. The results show that Hcy activated both ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B-DNA-binding activity. These effects were markedly inhibited by rosiglitazone as well as other inhibitors (SB203580, PD98059, and PDTC). Further, the pretreatment of staurosporine abrogated ERK{sub 1/2}/p38MAPK phosphorylation, suggesting that Hcy-induced ERK{sub 1/2}/p38MAPK activation is associated with PKC activity. Our results provide evidence that Hcy-induced NF-{kappa}B activation was mediated by activation of ERK{sub 1/2}/p38MAPK pathway involving PKC activity. Rosiglitazone reduces the NF-{kappa}B-mediated sICAM-1 and TNF-{alpha} production induced by Hcy via inhibition of ERK{sub 1/2}/p38MAPK pa0011thw.

  14. Best Management Practice #1: Water Management Planning

    Broader source: Energy.gov [DOE]

    A successful water management program starts with developing a comprehensive water management plan. This plan should be included within existing facility operating plans.

  15. Environmental Management Waste Management Facility (EMWMF) at...

    Office of Environmental Management (EM)

    Technical Review Report: Oak Ridge Reservation Review of the Environmental Management Waste Management Facility (EMWMF) at Oak Ridge By Craig H. Benson, PhD, PE; William H....

  16. Stormwater Management 

    E-Print Network [OSTI]

    Jaber, Fouad

    2008-10-23T23:59:59.000Z

    . Stormwater also may wash bacteria and other pathogens into swimming areas, creating health hazards that often close beaches. Stormwater may carry debris, such as plastic bags, six-pack rings, and cigarette butts, into water bodies; such debris can choke... the development and implementation of best management practices (BMPs) and achievement of measurable goals at levels sufficient to satisfy each of six minimum control measures and an optional seventh control measure: 1. Public education and outreach...

  17. Environmental Management

    ScienceCinema (OSTI)

    None

    2015-01-07T23:59:59.000Z

    Another key aspect of the NNSS mission is Environmental Management program, which addresses the environmental legacy from historic nuclear weapons related activities while also ensuring the health and safety of present day workers, the public, and the environment as current and future missions are completed. The Area 5 Radioactive Waste Management site receives low-level and mixed low-level waste from some 28 different generators from across the DOE complex in support of the legacy clean-up DOE Environmental Management project. Without this capability, the DOE would not be able to complete the clean up and proper disposition of these wastes. The program includes environmental protection, compliance, and monitoring of the air, water, plants, animals, and cultural resources at the NNSS. Investigation and implementation of appropriate corrective actions to address the contaminated ground water facilities and soils resulting from historic nuclear testing activities, the demolition of abandoned nuclear facilities, as well as installation of ground water wells to identify and monitor the extent of ground water contamination.

  18. Environmental Management

    SciTech Connect (OSTI)

    None

    2014-11-12T23:59:59.000Z

    Another key aspect of the NNSS mission is Environmental Management program, which addresses the environmental legacy from historic nuclear weapons related activities while also ensuring the health and safety of present day workers, the public, and the environment as current and future missions are completed. The Area 5 Radioactive Waste Management site receives low-level and mixed low-level waste from some 28 different generators from across the DOE complex in support of the legacy clean-up DOE Environmental Management project. Without this capability, the DOE would not be able to complete the clean up and proper disposition of these wastes. The program includes environmental protection, compliance, and monitoring of the air, water, plants, animals, and cultural resources at the NNSS. Investigation and implementation of appropriate corrective actions to address the contaminated ground water facilities and soils resulting from historic nuclear testing activities, the demolition of abandoned nuclear facilities, as well as installation of ground water wells to identify and monitor the extent of ground water contamination.

  19. Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-?B and MAPK pathways

    SciTech Connect (OSTI)

    Zeng, Ke-Wu [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Li, Jun [Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China); Dong, Xin; Wang, Ying-Hong; Ma, Zhi-Zhong; Jiang, Yong; Jin, Hong-Wei [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Tu, Peng-Fei, E-mail: pengfeitu@vip.163.com [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China)

    2013-11-15T23:59:59.000Z

    Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiovascular diseases. Therefore, AR inhibition seems to be a useful strategy for anti-inflammation therapy. In the central nervous system (CNS), microglial over-activation is considered to be a central event in neuroinflammation. However, the effects of AR inhibition in CNS inflammation and its underlying mechanism of action remain unknown. In the present study, we found that FMHM (a naturally derived AR inhibitor from the roots of Polygala tricornis Gagnep.) showed potent anti-neuroinflammatory effects in vivo and in vitro by inhibiting microglial activation and expression of inflammatory mediators. Mechanistic studies showed that FMHM suppressed the activity of AR-dependent phospholipase C/protein kinase C signaling, which further resulted in downstream inactivation of the I?B kinase/I?B/nuclear factor-kappa B (NF-?B) inflammatory pathway. Therefore, AR inhibition-dependent NF-?B inactivation negatively regulated the transcription and expression of various inflammatory genes. AR inhibition by FMHM exerted neuroprotective effects in lipopolysaccharide-induced neuron–microglia co-cultures. These findings suggested that AR is a potential target for neuroinflammation inhibition and that FMHM could be an effective agent for treating or preventing neuroinflammatory diseases. - Highlights: • FMHM is a natural-derived aldose reductase (AR) inhibitor. • FMHM inhibits various neuroinflammatory mediator productions in vitro and in vivo. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent NF-?B pathway. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent MAPK pathway. • FMHM protects neurons against inflammatory injury in microglia-neuron co-cultures.

  20. Impaired NFAT and NF?B activation are involved in suppression of CD40 ligand expression by ?{sup 9}-tetrahydrocannabinol in human CD4{sup +} T cells

    SciTech Connect (OSTI)

    Ngaotepprutaram, Thitirat [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Kaplan, Barbara L.F. [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Neuroscience Program, Michigan State University (United States); Kaminski, Norbert E., E-mail: kamins11@msu.edu [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States)

    2013-11-15T23:59:59.000Z

    We have previously reported that ?{sup 9}-tetrahydrocannabinol (?{sup 9}-THC), the main psychoactive cannabinoid in marijuana, suppresses CD40 ligand (CD40L) expression by activated mouse CD4{sup +} T cells. CD40L is involved in pathogenesis of many autoimmune and inflammatory diseases. In the present study, we investigated the molecular mechanism of ?{sup 9}-THC-mediated suppression of CD40L expression using peripheral blood human T cells. Pretreatment with ?{sup 9}-THC attenuated CD40L expression in human CD4{sup +} T cells activated by anti-CD3/CD28 at both the protein and mRNA level, as determined by flow cytometry and quantitative real-time PCR, respectively. Electrophoretic mobility shift assays revealed that ?{sup 9}-THC suppressed the DNA-binding activity of both NFAT and NF?B to their respective response elements within the CD40L promoter. An assessment of the effect of ?{sup 9}-THC on proximal T cell-receptor (TCR) signaling induced by anti-CD3/CD28 showed significant impairment in the rise of intracellular calcium, but no significant effect on the phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?. Collectively, these findings identify perturbation of the calcium-NFAT and NF?B signaling cascade as a key mechanistic event by which ?{sup 9}-THC suppresses human T cell function. - Highlights: • ?{sup 9}-THC attenuated CD40L expression in activated human CD4+ T cells. • ?{sup 9}-THC suppressed DNA-binding activity of NFAT and NF?B. • ?{sup 9}-THC impaired elevation of intracellular Ca2+. • ?{sup 9}-THC did not affect phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?.

  1. Risk Management, Mar 2012 Risk Management

    E-Print Network [OSTI]

    Risk Management, Mar 2012 Risk Management Conditions of Volunteer Service (Please send completed form to the Office of Risk Management) riskmanagement@uoregon.edu Fax: 541-346-7008 As a volunteer Tort Claims Act, ORS 30.260-300, and Oregon Department of Administrative Services Risk Management

  2. Risk Management Procedures Category: Strategic Management

    E-Print Network [OSTI]

    1 Risk Management Procedures Category: Strategic Management 1. LEGISLATION/ENTERPRISE AGREEMENT/POLICY SUPPORTED Risk Management Policy Tertiary Education Quality Standards Agency Act 2011 (TEQSA Act 2011) 2 (a) Advise the Vice-Chancellor on the effective management of the University's risk profile

  3. Landscape Management Systems The Visual Management System

    E-Print Network [OSTI]

    Standiford, Richard B.

    Landscape Management Systems The Visual Management System of the Forest Service, USDA1 Warren R presentation on how the Visual Management System (VMS) functions. 1/ Presented at the National Conference Manual 2380, Landscape Management, USDA. INTRODUCTION The American people are concerned about the quality

  4. Management 301 Management and Organizational Behavior

    E-Print Network [OSTI]

    Young, Paul Thomas

    Management 301 Management and Organizational Behavior Section 003 Fall 2013 (8/20-12/3) College approaches management as that process of reaching organizational goals by working with and through people. Course Objectives 1. To understand management and organizational behavior (ob) concepts associated

  5. Data Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisitingContract Management Fermi SitePARTOfficeOctoberDaniel WoodID Service FirstData

  6. Data Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisitingContract Management Fermi SitePARTOfficeOctoberDaniel WoodID Service

  7. Data Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisitingContract Management Fermi SitePARTOfficeOctoberDaniel WoodID ServiceData

  8. SUBCONTRACT MANAGEMENT

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin ofEnergy atLLC - FE DKT. 10-160-LNG - ORDERSTATE0-1 CHAPTER 10 SUBCONTRACT MANAGEMENT

  9. Management Overview

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |IsLove Your Home and It'll LoveMail andAbout UsManagement

  10. The NSVZ beta-function and the Schwinger-Dyson equations for N=1 SQED with N_f flavors, regularized by higher derivatives

    E-Print Network [OSTI]

    K. V. Stepanyantz

    2014-06-08T23:59:59.000Z

    The effective diagram technique based on the Schwinger-Dyson equations is constructed for N=1 SQED with N_f flavors, regularized by higher derivatives. Using these effective diagrams, it is possible to derive the exact NSVZ relation between the beta-function and the anomalous dimension of the matter superfields exactly in all loops, if the renormalization group functions are defined in terms of the bare coupling constant. In particular, we verify that all integrals which give the beta-function defined in terms of the bare coupling constant are integrals of double total derivatives and prove some identities relating Green functions.

  11. NF_Eder_2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Saleshttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gif Directorate1, Issue 23 NETL NEVIS- 97NEWS RELEASE For3

  12. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-{kappa}B activation and the JAK/STAT pathway

    SciTech Connect (OSTI)

    Lv, Na; Kim, Eun-Kyung; Song, Mi-Young [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Choi, Ha-Na; Moon, Woo Sung [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Park, Sung-Joo [Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of)] [Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Jin-Woo [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Kwon, Kang-Beom, E-mail: desson@wonkwang.ac.kr [Department of Physiology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of)] [Department of Physiology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Byung-Hyun, E-mail: bhpark@chonbuk.ac.kr [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)

    2009-07-15T23:59:59.000Z

    JANEX-1/WHI-P131, a selective Janus kinase 3 (JAK3) inhibitor, has been shown to delay the onset of diabetes in the NOD mouse model. However, the molecular mechanism by which JANEX-1 protects pancreatic {beta}-cells is unknown. In the current study, we investigated the role of JANEX-1 on interleukin (IL)-1{beta} and interferon (IFN)-{gamma}-induced {beta}-cell damage using isolated islets. JANEX-1-pretreated islets showed resistance to cytokine toxicity, namely suppressed nitric oxide (NO) production, reduced inducible form of NO synthase (iNOS) expression, and decreased islet destruction. The molecular mechanism by which JANEX-1 inhibits iNOS expression was mediated through suppression of the nuclear factor {kappa}B (NF-{kappa}B) and JAK/signal transducer and activator of transcription (STAT) pathways. Islets treated with the cytokines downregulated the protein levels of suppressor of cytokine signaling (SOCS)-1 and SOCS-3, but pretreatment with JANEX-1 attenuated these decreases. Additionally, islets from JAK3{sup -/-} mice were more resistant to cytokine toxicity than islets from control mice. These results demonstrate that JANEX-1 protects {beta}-cells from cytokine toxicity through suppression of the NF-{kappa}B and JAK/STAT pathways and upregulation of SOCS proteins, suggesting that JANEX-1 may be used to preserve functional {beta}-cell mass.

  13. Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-?B in 4-nitroquinoline 1-oxide-induced murine oral cancer model

    SciTech Connect (OSTI)

    Liu, Yu-Ching [Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan (China) [Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan (China); Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan (China); Ho, Heng-Chien; Lee, Miau-Rong [Department of Biochemistry, China Medical University, Taichung 404, Taiwan (China)] [Department of Biochemistry, China Medical University, Taichung 404, Taiwan (China); Lai, Kuang-Chi [Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan (China) [Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan (China); School of Medicine, China Medical University, Taichung 404, Taiwan (China); Yeh, Chung-Min; Lin, Yueh-Min [Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan (China)] [Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan (China); Ho, Tin-Yun [School of Chinese Medicine, China Medical University, Taichung 404, Taiwan (China)] [School of Chinese Medicine, China Medical University, Taichung 404, Taiwan (China); Hsiang, Chien-Yun, E-mail: cyhsiang@mail.cmu.edu.tw [Department of Microbiology, China Medical University, Taichung 404, Taiwan (China)] [Department of Microbiology, China Medical University, Taichung 404, Taiwan (China); Chung, Jing-Gung, E-mail: jgchung@mail.cmu.edu.tw [Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan (China) [Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan (China); Department of Biotechnology, Asia University, Taichung 413, Taiwan (China)

    2012-07-15T23:59:59.000Z

    The purpose of this study was to identify the genes induced early in murine oral carcinogenesis. Murine tongue tumors induced by the carcinogen, 4-nitroquinoline 1-oxide (4-NQO), and paired non-tumor tissues were subjected to microarray analysis. Hierarchical clustering of upregulated genes in the tumor tissues revealed an association of induced genes with inflammation. Cytokines/cytokine receptors induced early were subsequently identified, clearly indicating their involvement in oral carcinogenesis. Hierarchical clustering also showed that cytokine-mediated inflammation was possibly linked with Mapk6. Cox2 exhibited the greatest extent (9–18 fold) of induction in the microarray data, and its early induction was observed in a 2 h painting experiment by RT-PCR. MetaCore analysis showed that overexpressed Cox2 may interact with p53 and transcriptionally inhibit expression of several downstream genes. A painting experiment in transgenic mice also demonstrated that NF-?B activates early independently of Cox2 induction. MetaCore analysis revealed the most striking metabolic alterations in tumor tissues, especially in lipid metabolism resulting from the reduction of Ppar? and Rxrg. Reduced expression of Mapk12 was noted, and MetaCore analysis established its relationship with decreased efficiency of Ppar? phosphorylation. In conclusion, in addition to cytokines/cytokine receptors, the early induction of Cox2 and NF-?B activation is involved in murine oral carcinogenesis.

  14. High-loop perturbative renormalization constants for Lattice QCD (III): three-loop quark currents for Iwasaki gauge action and n_f=4 Wilson fermions

    E-Print Network [OSTI]

    M. Brambilla; F. Di Renzo; M. Hasegawa

    2014-06-23T23:59:59.000Z

    This is the third of a series of papers on three-loop computation of renormalization constants for Lattice QCD. Our main point of interest are results for the regularization defined by Iwasaki gauge action and n_f=4 Wilson fermions. Our results for quark bilinears renormalized according to the RI'-MOM scheme can be compared to non-perturbative results. The latter are available for Twisted Mass QCD: being defined in the chiral limit, renormalization constants must be the same. We also address more general problems. In particular, we discuss a few methodological issues connected to summing the perturbative series such as the effectiveness of Boosted Perturbation Theory and the disentanglement of irrelevant and finite volume contributions. Discussing these issues we consider ont only the new results of this paper, but also those for the regularization defined by tree-level Symanzik improved gauge action and n_f=2 Wilson fermions, which we presented in a recent paper of ours. We finally comment to which extent the techniques we put at work in the NSPT context can provide a fresher look into the lattice version of the RI'-MOM scheme.

  15. BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PL LDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN

    E-Print Network [OSTI]

    Florida, University of

    BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PL LDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN BUILDING A R RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN BUILDIN T PLAN BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEM

  16. Enterprise Risk Management Program

    E-Print Network [OSTI]

    Hayden, Nancy J.

    Enterprise Risk Management Program Guide to Risk Assessment & Response August 16, 2012 #12; i ...........26 List of Figures Figure 1: The Risk Management Process.......................................................................................................12 #12; 1 Overview The risk management process--of identifying, analyzing, evaluating

  17. IT Project Manager

    Broader source: Energy.gov [DOE]

    This position is located in the IT Project Management Office (JP). A successful candidate in this position will serve as an IT Program Manager and technical expert responsible for directly managing...

  18. environmental management radiation protection

    E-Print Network [OSTI]

    Entekhabi, Dara

    EHS environmental management biosafety radiation protection industrial hygiene safety Working: Biosafety, Environmental Management, Industrial Hygiene, Radiation Protection and Safety. Each specialized Management Program, Industrial Hygiene, Radiation Protection Program, and the Safety Program. (http

  19. Functional Facilities Management Energy Management Structure

    E-Print Network [OSTI]

    Gulliver, Robert

    Functional Facilities Management Energy Management Structure Jerome Malmquist Director Erick Van Controls Systems Jeff Davis Assistant Director, Facilities Engineering & Energy Efficiency Gene Husted Principal Engineer / Commissioning Emily Robin-Abbott St. Paul Energy Engineer & Technicians Supervisor Dan

  20. Energy Management Working Group: Accelerating Energy Management

    E-Print Network [OSTI]

    Scheihing, P.

    2014-01-01T23:59:59.000Z

    for Standardization (ISO) published the ISO 50001 energy management standard in 2011. ISO 50001 provides industrial companies with guidelines for integrating energy efficiency into their management practices— including fine-tuning production processes... efficiency. GSEP’s Energy Management Working Group (EMWG) advocates the increased adoption of EnMS or ISO 50001 in industry and commercial buildings. It goal is to accelerate the adoption and use of energy management systems in industrial facilities...

  1. Load Management for Industry

    E-Print Network [OSTI]

    Konsevick, W. J., Jr.

    1982-01-01T23:59:59.000Z

    customer management programs exist. EPRI Report (EM-1606) loads to beneficially alter a'utility's load curve. (Page 1-2) list them as: Load management alternatives are covered. 1. Direct or voluntary control of customer Load management methods can... and Electric Power Research Institute (EPRI) Report energy management programs. (EM-1606) states that "the objective of load manage ment is to alter the real or apparent pattern of Our load management program was designed electricity use in order to...

  2. Managing Web Data Managing Web Data

    E-Print Network [OSTI]

    Davulcu, Hasan

    Managing Web Data Dan Suciu AT&T Labs Managing Web Data Sigmod, 1999 Dan Suciu AT&T Labs 1 #12;How the Web is Today HTML documents all intended for human consumption many are generated automatically by applications Managing Web Data Sigmod, 1999 Dan Suciu AT&T Labs 2 #12;Paradigm Shift on the Web applications

  3. MATERIALS MANAGEMENT MATERIALS MANAGEMENT -INVENTORY CONTROL

    E-Print Network [OSTI]

    Oliver, Douglas L.

    MATERIALS MANAGEMENT MATERIALS MANAGEMENT - INVENTORY CONTROL NOTICE OF DESIGNATED DEPARTMENTAL OF MATERIALS MANAGEMENT ______ FURTHER INSTRUCTIONS 1. Include a copy of any relevant documents. 2. Item MATERIALS COORDINATOR ­ IC-8 Mail, Fax or PDF the entire package to: MC 2010 Fax: 679-4240 REFERENCE # DMC

  4. Physics Department Management Review

    E-Print Network [OSTI]

    Homes, Christopher C.

    ESSH Committee and Work Planning Security Cyber Security Accident and Incident Management was distributed to the ESSH Committee, Group Leaders, Group Safety Coordinators, and Line Management #12;Areas

  5. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    by FY12. 95% Line Item 85% Cleanup 97% Line Item 85% Cleanup EVM represents Earned Value Management. FY2011 Second Quarter Overall Contract and Project Management Improvement...

  6. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    by FY12. 95% Line Item 85% Cleanup 100% Line Item 88% Cleanup EVM represents Earned Value Management. FY2011 Fourth Quarter Overall Contract and Project Management Improvement...

  7. Contract/Project Management

    Energy Savers [EERE]

    by FY12. 95% Line Item 85% Cleanup 100% Line Item 88% Cleanup EVM represents Earned Value Management. FY2011 First Quarter Overall Contract and Project Management Performance...

  8. Contract/Project Management

    Energy Savers [EERE]

    by FY12. 95% Line Item 85% Cleanup 97% Line Item 89% Cleanup EVM represents Earned Value Management. FY2011 Third Quarter Overall Contract and Project Management Improvement...

  9. Management of Nuclear Materials

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-08-17T23:59:59.000Z

    To establish requirements for the lifecycle management of DOE owned and/or managed accountable nuclear materials. Cancels DOE O 5660.1B.

  10. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    3 rd Quarter Overall Contract and Project Management Performance Metrics and Targets ContractProject Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1....

  11. Target Cost Management Strategy

    E-Print Network [OSTI]

    Okano, Hiroshi

    1996-01-01T23:59:59.000Z

    Target cost management (TCM) is an innovation of Japanese management accounting system and by common sense has been considered with great interest by practitioners. Nowadays, TCM related

  12. A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-?B and Nrf2-Keap1 signaling pathways

    SciTech Connect (OSTI)

    Gan, Fei-Fei; Ling, Hui; Ang, Xiaohui; Reddy, Shridhivya A.; Lee, Stephanie S-H.; Yang, Hong; Tan, Sock-Hoon [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore); Hayes, John D. [Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland (United Kingdom); Chui, Wai-Keung [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore); Chew, Eng-Hui, E-mail: phaceh@nus.edu.sg [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore)

    2013-11-01T23:59:59.000Z

    Natural compounds containing vanilloid and Michael acceptor moieties appear to possess anti-cancer and chemopreventive properties. The ginger constituent shogaol represents one such compound. In this study, the anti-cancer potential of a synthetic novel shogaol analog 3-phenyl-3-shogaol (3-Ph-3-SG) was assessed by evaluating its effects on signaling pathways. At non-toxic concentrations, 3-Ph-3-SG suppressed cancer cell invasion in MDA-MB-231 and MCF-7 breast carcinoma cells through inhibition of PMA-activated MMP-9 expression. At similar concentrations, 3-Ph-3-SG reduced expression of the inflammatory mediators nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and prostanglandin-E{sub 2} (PGE{sub 2}) in RAW 264.7 macrophage-like cells. Inhibition of cancer cell invasion and inflammation by 3-Ph-3-SG were mediated through suppression of the nuclear factor-kappaB (NF-?B) signaling pathway. The 3-Ph-3-SG also demonstrated cytoprotective effects by inducing the antioxidant response element (ARE)-driven genes NAD(P)H quinone oxidoreductase-1 (NQO1) and heme oxygenase-1 (HO-1). Cytoprotection by 3-Ph-3-SG was achieved at least partly through modification of cysteine residues in the E3 ubiquitin ligase substrate adaptor Kelch-like ECH-associated protein 1 (Keap1), which resulted in accumulation of transcription factor NF-E2 p45-related factor 2 (Nrf2). The activities of 3-Ph-3-SG were comparable to those of 6-shogaol, the most abundant naturally-occurring shogaol, and stronger than those of 4-hydroxyl-null deshydroxy-3-phenyl-3-shogaol, which attested the importance of the 4-hydroxy substituent in the vanilloid moiety for bioactivity. In summary, 3-Ph-3-SG is shown to possess activities that modulate stress-associated pathways relevant to multiple steps in carcinogenesis. Therefore, it warrants further investigation of this compound as a promising candidate for use in chemotherapeutic and chemopreventive strategies. - Highlights: • Novel shogaol 3-phenyl-3-shogaol suppressed cancer cell invasion and inflammation. • Anti-invasive and anti-inflammatory effects were NF-?B-dependent. • 3-Phenyl-3-shogaol induced ARE-driven genes to achieve cytoprotection. • Cytoprotective effects were brought about by modification of cysteines in Keap1. • Chemopreventive activities of 3-phenyl-3-shogaol and 6-shogaol were comparable.

  13. Microtrenching-free two-step reactive ion etching of 4H-SiC using NF{sub 3}/HBr/O{sub 2} and Cl{sub 2}/O{sub 2}

    SciTech Connect (OSTI)

    Tseng, Yuan-Hung, E-mail: yhtseng.ee99g@nctu.edu.tw; Tsui, Bing-Yue [Department of Electronics Engineering, National Chiao Tung University, No. 1001, Daxue Rd., East Dist., Hsinchu City 30010, Taiwan (China)

    2014-05-15T23:59:59.000Z

    In this paper, the authors performed a reactive ion etch of a 4H-SiC substrate with a gas mixture of NF{sub 3}, HBr, and O{sub 2}, resulting in a microtrenching-free etch. The etch rate was 107.8?nm/min, and the selectivity over the oxide hard mask was ?3.85. Cross-sectional scanning electron microscopy showed no microtrenching compared with etches using plasmas of NF{sub 3}, NF{sub 3}/HBr, and NF{sub 3}/O{sub 2}. Analyzing a variety of HBr/O{sub 2} mixing ratios, the authors discuss the additive effect of each gas and their respective potential mechanisms for alleviating microtrenching. To increase the radius of gyration of the bottom corners, they introduced a second etch step with Cl{sub 2}/O{sub 2} plasma. Fabricating simple metal-oxide-semiconductor capacitors on the two-step etched surface, the authors found that the electrical characteristics of the etched sample were nearly the same as the nonetched sample.

  14. Best Environmental Management Practices

    E-Print Network [OSTI]

    Best Environmental Management Practices Farm Animal Production Comprehensive Nutrient Management with regulatory guidelines by addressing items such as manure management, field crop nutrients, and storm water What is a CNMP? A Comprehensive Nutrient Management Plan (CNMP) is a total planning tool that details

  15. Environmental Best Management Practices

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    Environmental Best Management Practices for Virginia's Golf Courses Prepared by Virginia Golf Course Superintendents Association #12;#12;EnvironmEntal BEst managEmEnt PracticEs for virginia's golf III I am pleased to endorse the Environmental Best Management Practices for Virginia's Golf Courses

  16. Sport Management Academic Offerings

    E-Print Network [OSTI]

    Mather, Patrick T.

    production and programming of events; marketing and public relations; technological operations management including (but not limited to) digital advertising, media law, new media business, operations managementSport Management Academic Offerings M.S. In Sport Venue And Event Management GRADUATE Chad Mc

  17. Chemical Management Contacts

    Broader source: Energy.gov [DOE]

    Contacts for additional information on Chemical Management and brief description on Energy Facility Contractors Group

  18. Relation between two-point Green functions of ${\\cal N}=1$ SQED with $N_f$ flavors, regularized by higher derivatives, in the three-loop approximation

    E-Print Network [OSTI]

    A. E. Kazantsev; K. V. Stepanyantz

    2014-10-05T23:59:59.000Z

    We verify the identity which relates the two-point Green functions of ${\\cal N}=1$ SQED with $N_f$ flavors, regularized by higher derivatives, by explicit calculations in the three-loop approximation. This identity explains why in the limit of the vanishing external momentum the two-point Green function of the gauge superfield is given by integrals of double total derivatives in the momentum space. It also allows to derive the NSVZ $\\beta$-function exactly in all loops if the renormalization group functions are defined in terms of the bare coupling constant. In order to verify the considered identity we use it for constructing integrals giving the three-loop $\\beta$-function starting from the two-point Green functions of the matter superfields in the two-loop approximation. Then we demonstrate that the results for these integrals coincide with the sums of the corresponding three-loop supergraphs.

  19. Information resource management concepts for records managers

    SciTech Connect (OSTI)

    Seesing, P.R.

    1992-10-01T23:59:59.000Z

    Information Resource Management (ERM) is the label given to the various approaches used to foster greater accountability for the use of computing resources. It is a corporate philosophy that treats information as it would its other resources. There is a reorientation from simply expenditures to considering the value of the data stored on that hardware. Accountability for computing resources is expanding beyond just the data processing (DP) or management information systems (MIS) manager to include senior organization management and user management. Management`s goal for office automation is being refocused from saving money to improving productivity. A model developed by Richard Nolan (1982) illustrates the basic evolution of computer use in organizations. Computer Era: (1) Initiation (computer acquisition), (2) Contagion (intense system development), (3) Control (proliferation of management controls). Data Resource Era: (4) Integration (user service orientation), (5) Data Administration (corporate value of information), (6) Maturity (strategic approach to information technology). The first three stages mark the growth of traditional data processing and management information systems departments. The development of the IRM philosophy in an organization involves the restructuring of the DP organization and new management techniques. The three stages of the Data Resource Era represent the evolution of IRM. This paper examines each of them in greater detail.

  20. 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-{kappa}B and ERK/MAPK

    SciTech Connect (OSTI)

    Chen Zhihua [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Na, Hye-Kyung [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Hurh, Yeon-Jin [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Surh, Young-Joon [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of)]. E-mail: surh@plaza.snu.ac.kr

    2005-10-01T23:59:59.000Z

    Catechol estrogens, the hydroxylated metabolites of 17{beta}-estradiol (E{sub 2}), have been considered to be implicated in estrogen-induced carcinogenesis. 4-Hydroxyestradiol (4-OHE{sub 2}), an oxidized metabolite of E{sub 2} formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-OHE{sub 2} undergoes 2-electron oxidation to quinone via semiquinone, and during this process, reactive oxygen species (ROS) can be generated to cause DNA damage and cell death. In the present study, 4-OHE{sub 2} was found to elicit cytotoxicity in cultured human mammary epithelial (MCF-10A) cells, which was blocked by the antioxidant trolox. MCF-10A cells treated with 4-OHE{sub 2} exhibited increased intracellular ROS accumulation and 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, and underwent apoptosis as determined by poly(ADP-ribose)polymerase cleavage and disruption of mitochondrial transmembrane potential. The redox-sensitive transcription factor nuclear factor {kappa}B (NF-{kappa}B) was transiently activated by 4-OHE{sub 2} treatment. Cotreatment of MCF-10A cells with the NF-{kappa}B inhibitor, L-1-tosylamido-2-phenylethyl chloromethyl ketone, exacerbated 4-OHE{sub 2}-induced cell death. 4-OHE{sub 2} also caused transient activation of extracellular signal-regulated protein kinases (ERK) involved in transmitting cell survival or death signals. A pharmacological inhibitor of ERK aggravated the 4-OHE{sub 2}-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death.

  1. Management and Program Analyst (Operations Manager)

    Broader source: Energy.gov [DOE]

    A successful candidate in this position will serve as a Management and Program Analyst in the Office of Strategic Programs in the DOE-EERE.

  2. Information resource management concepts for records managers

    SciTech Connect (OSTI)

    Seesing, P.R.

    1992-10-01T23:59:59.000Z

    Information Resource Management (ERM) is the label given to the various approaches used to foster greater accountability for the use of computing resources. It is a corporate philosophy that treats information as it would its other resources. There is a reorientation from simply expenditures to considering the value of the data stored on that hardware. Accountability for computing resources is expanding beyond just the data processing (DP) or management information systems (MIS) manager to include senior organization management and user management. Management's goal for office automation is being refocused from saving money to improving productivity. A model developed by Richard Nolan (1982) illustrates the basic evolution of computer use in organizations. Computer Era: (1) Initiation (computer acquisition), (2) Contagion (intense system development), (3) Control (proliferation of management controls). Data Resource Era: (4) Integration (user service orientation), (5) Data Administration (corporate value of information), (6) Maturity (strategic approach to information technology). The first three stages mark the growth of traditional data processing and management information systems departments. The development of the IRM philosophy in an organization involves the restructuring of the DP organization and new management techniques. The three stages of the Data Resource Era represent the evolution of IRM. This paper examines each of them in greater detail.

  3. The Waste Management Quality Assurance Implementing Management Plan (QAIMP)

    E-Print Network [OSTI]

    Albert editor, R.

    2009-01-01T23:59:59.000Z

    DIVISION Waste Management Quality Assurance ImplementingI I IMPLEMENTING MANAGEMENT QUALITY PLAN ASSURANCE I lilillI WM-QAIMP Waste Management Quality Assurance Implementing

  4. Fusing Integration Test Management with Change Management

    E-Print Network [OSTI]

    Perry, Dewayne E.

    - 1 - Infuse: Fusing Integration Test Management with Change Management Gail E. Kaiser* Dewayne E, NJ 07974 Murray Hill, NJ 07974 Infuse is an experimental software development environment focusing the change set into the baseline. We have previously described how Infuse enforces static consistency at each

  5. Waste Management Quality Assurance Plan

    E-Print Network [OSTI]

    Waste Management Group

    2006-01-01T23:59:59.000Z

    Revision 6 Waste Management Quality Assurance Plan Waste6 WM QA Plan Waste Management Quality Assurance Plan LBNL/4 Management Quality Assurance

  6. Ground Water Management Act (Virginia)

    Broader source: Energy.gov [DOE]

    Under the Ground Water Management Act of 1992, Virginia manages ground water through a program regulating the withdrawals in certain areas called Ground Water Management Areas (GWMA). Currently,...

  7. Business, management and finance

    E-Print Network [OSTI]

    Sussex, University of

    Business, management and finance Essentials Taught degrees Masters in Business Administration (MBA) MSc in Banking and Finance MSc in Corporate and Financial Risk Management MSc in Financial Mathematics MSc in International Accounting and Corporate Governance MSc in International Finance MSc

  8. Information Technology Project Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-03T23:59:59.000Z

    The Order provides program and project management direction for the acquisition and management of IT projects, investments, and initiatives. Cancels DOE G 200.1-1. Admin Chg 1, dated 1-16-2013, cancels DOE O 415.1.

  9. Portfolio Manager Overview

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Portfolio Manager 3 | TAP Webcast eere.energy.gov What is Portfolio Manager? Free, web-based tool for benchmarking existing buildings Measure and track the energy use of...

  10. Risk Management Guide

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-01-18T23:59:59.000Z

    This Guide provides non-mandatory risk management approaches for implementing the requirements of DOE O 413.3B, Program and Project Management for the Acquisition of Capital Assets. Cancels DOE G 413.3-7.

  11. ENVIRONMENTAL MANAGEMENT Environmental Policy

    E-Print Network [OSTI]

    Haase, Markus

    ENVIRONMENTAL MANAGEMENT Environmental Policy February 2013 The University of Leeds is responsible to reflect best environmental practice, implement an environmental management system to pursue sustainability and continuous improvement and seek innovative ways of meeting environmental objectives. These include: To meet

  12. Information Technology Project Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-03T23:59:59.000Z

    The Order provides program and project management direction for the acquisition and management of IT projects, investments, and initiatives. Cancels DOE G 200.1-1. Admin Chg 1 approved 1-16-2013.

  13. Computerized Maintenance Management Systems

    Broader source: Energy.gov [DOE]

    Computerized maintenance management systems (CMMS) are a type of management software that perform functions in support of operations and maintenance (O&M) programs. The software automates most of the logistical functions performed by O&M staff.

  14. Management of Nuclear Materials

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-08-17T23:59:59.000Z

    To establish requirements for the lifecycle management of DOE owned and/or managed accountable nuclear materials. Cancels DOE O 410.2. Admin Chg 1 dated 4-10-2014, cancels DOE O 410.2.

  15. Personalized diabetes management

    E-Print Network [OSTI]

    O'Hair, Allison Kelly

    2013-01-01T23:59:59.000Z

    In this thesis, we present a system to make personalized lifestyle and health decisions for diabetes management, as well as for general health and diet management. In particular, we address the following components of the ...

  16. Coastal Management Act (Georgia)

    Broader source: Energy.gov [DOE]

    The Coastal Management Act provides enabling authority for the State to prepare and administer a coastal management program. The Act does not establish new regulations or laws; it is designed to...

  17. Wildlife Management Areas (Florida)

    Broader source: Energy.gov [DOE]

    Certain sites in Florida are designated as wildlife management areas, and construction and development is heavily restricted in these areas.

  18. Benchmarking Corporate Energy Management

    E-Print Network [OSTI]

    Norland, D. L.

    BENCHMARKING CORPORATE ENERGY MANAGEMENT Dr. Douglas L. Norland Director of Research and Industrial Programs Alliance to Save Energy Washington, DC ABSTRACT There is growing interest among energy managers in finding out how their company...'s energy management procedures and perfonnance compare to that of other companies. Energy management involves everything from setting goals and targets to implementing best maintenance practices. This paper, however, discusses benchmarking energy...

  19. Workforce Management Office (WFMO) Functional Statements WORKFORCE MANAGEMENT OFFICE

    E-Print Network [OSTI]

    , and destruction. BMD oversees WFMO's personal property management, Freedom of Information Act responses, Entry, organizing, and administering comprehensive human resources management programs in collaboration wMay 2014 Workforce Management Office (WFMO) ­ Functional Statements WORKFORCE MANAGEMENT OFFICE

  20. Business, management and finance

    E-Print Network [OSTI]

    Sussex, University of

    Business, management and finance Essentials Taught degrees Masters in Business Administration (MBA) MSc in Banking and Finance MSc in Corporate and Financial Risk Management MSc in Financial Mathematics in International Accounting and Corporate Governance MSc in International Finance MSc in International Management

  1. Risk Management Strategy Introduction

    E-Print Network [OSTI]

    Edinburgh, University of

    Risk Management Strategy Introduction 1. The risk of adverse consequences is inherent in all activity. Dynamic enterprise will inevitably create new risks. Risk management is about ensuring that all significant relevant risks are understood and prioritised as part of normal management

  2. Forest Resources and Management

    E-Print Network [OSTI]

    Forest Resources and Management Centre for The Centre for Forest Resources and Management aims the forest resource. Our aim is that British forests ­ from their creation to maturity and regeneration-energy development, forest resource forecasting, genetic improvement, woodland regeneration and creation, management

  3. Environmental Management at

    E-Print Network [OSTI]

    : ANUgreen for the HotRot Organic Recycling Project Sustainable Transport Category Winner: LEAD Development Themes: 1. Community Engagement 2. Energy and Greenhouse Management 3. Water Management 4. Recycling and Waste Management 5. Transport 6. Pollution Prevention and Environmental Risk 7. Biodiversity The Future

  4. Medical Management Treatment Manual

    E-Print Network [OSTI]

    Bezrukov, Sergey M.

    Medical Management Treatment Manual: A Clinical Guide for Researchers and Clinicians) This manual is an adaptation of: Medical Management Treatment Manual: A Clinical Research Guide for Medically, Maryland #12;Message to the Users of this Medical Management (MM) Manual from the Editors Background

  5. FRESH THINKING FOR MANAGEMENT

    E-Print Network [OSTI]

    Yang, Eui-Hyeok

    FOR TECHNOLOGY MANAGEMENT Technology Acceptance in Organizations: What Can We Do to Improve it? by Patricia in organizations is thus an important topic in both management research and management practice. Technology choice of a mobile phone. In organizations, there are two steps in technology adoption. First

  6. Records Management Administration & Finance

    E-Print Network [OSTI]

    Wu, Shin-Tson

    SUBJECT: Records Management Administration & Finance Number: 4010 Effective Date: 02 applies to the retention and disposal of public records. The university records management liaison officer for Administration and Finance,will provide liaison and assistance in allphases of the records management process

  7. Database Management Certificate Program

    E-Print Network [OSTI]

    Rose, Michael R.

    Database Management Certificate Program DATABASE TECHNOLOGIES 13 Today, organizations in every to obtain general data analysis and management skills or apply both Oracle and Microsoft SQL Server database capabilities of relational databases in conjunction with the new "Big Data" management frameworks for data

  8. Financial Management Oversight

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-08-31T23:59:59.000Z

    The Order defines requirements for effective financial management and adherence to DOE and applicable external financial management requirements and sets forth standards for ensuring the integrity and responsiveness of financial management and the accuracy and reliability of DOEs financial statements. Cancels DOE O 2200.13.

  9. Risk & QualityRisk & Quality ManagementManagement

    E-Print Network [OSTI]

    liability."" [Balsaono RR, Brown[Balsaono RR, Brown MK, Risk ManagementMK, Risk Management inin Legal

  10. CAMPUS BLUEPRINT ENROLLMENT MANAGEMENT COUNCIL'S

    E-Print Network [OSTI]

    Powers, Robert

    CAMPUS BLUEPRINT ENROLLMENT MANAGEMENT COUNCIL'S STRATEGIC ENROLLMENT MANAGEMENT PLAN 2012'S ENROLLMENT MANAGEMENT COUNCIL'S STRATEGIC ENROLLMENT MANAGEMENT PLAN 2012-2017 Report Outline Building a Big: Student Recruitment Initiatives Sharing Our Story of Quality Improving the Academic Profile and Student

  11. CSREES Nutrient Management Working Meeting

    E-Print Network [OSTI]

    planning process ­ Nutrient management training ­ P-Indexes and tools developed ­ Educational materials #12Welcome CSREES Nutrient Management Working Meeting May 4 and 5, 2004 Atlanta, GA #12;University Objectives · Information Sharing Among States ­ Nutrient management regulations ­ Nutrient management

  12. Radioactive Waste Management Basis

    SciTech Connect (OSTI)

    Perkins, B K

    2009-06-03T23:59:59.000Z

    The purpose of this Radioactive Waste Management Basis is to describe the systematic approach for planning, executing, and evaluating the management of radioactive waste at LLNL. The implementation of this document will ensure that waste management activities at LLNL are conducted in compliance with the requirements of DOE Order 435.1, Radioactive Waste Management, and the Implementation Guide for DOE Manual 435.1-1, Radioactive Waste Management Manual. Technical justification is provided where methods for meeting the requirements of DOE Order 435.1 deviate from the DOE Manual 435.1-1 and Implementation Guide.

  13. Army Regulation 2550 Information Management: Records

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Army Regulation 25­50 Information Management: Records Management Preparing and Managing Information Management: Records Management Preparing and Managing Correspondence *Army Regulation 25. This regulation on the prepa- ration and management of Army corre- spondence has been revised. This revision

  14. Strategies for Successful Energy Management

    Broader source: Energy.gov [DOE]

    This presentation, given through the DOE's Technical Assitance Program (TAP), provides information on energy management for the portfolio manager initiative

  15. A Manager's Approach to Energy Cost Management

    E-Print Network [OSTI]

    Spencer, R. J.

    A major responsibility of management is the control and containment of operating costs. Energy costs are a major portion of the industrial budget. GM has developed a 3 phase approach to energy conservation. Phase I -Administrative Controls...

  16. Energy Management Working Group: Accelerating Energy Management 

    E-Print Network [OSTI]

    Scheihing, P.

    2014-01-01T23:59:59.000Z

    Countries participating in the Global Superior Energy Performance (GSEP) Energy Management Working Group (EMWG) are leveraging their resources and taking collective action to strengthen national and international efforts to facilitate the adoption...

  17. Rangeland Drought Management for Texans: Livestock Management

    E-Print Network [OSTI]

    Carpenter, Bruce B.; Hart, Charles R.

    2001-04-24T23:59:59.000Z

    Livestock producers need to create flexible plans for dealing with drought. This publication explains the steps that should be included in such a plan, including taking a forage inventory, using stocker animals, establishing a livestock management...

  18. Nutrient Management TrainingNutrient Management Training for Technical Service Providersfor Technical Service Providers

    E-Print Network [OSTI]

    Nutrient ManagementNutrient Management ­­ Record KeepingRecord Keeping ­­ Feed ManagementFeed ManagementNutrient Management TrainingNutrient Management Training for Technical Service Providersfor Management Planning Technical Guidance.Management Planning Technical Guidance. Manure and Wastewater Handling

  19. Nature of Roberge-Weiss transition end points for heavy quarks in $N_f=2$ lattice QCD with Wilson fermions

    E-Print Network [OSTI]

    Liang-Kai Wu; Xiang-Fei Meng

    2014-10-26T23:59:59.000Z

    The phase structure of QCD with imaginary chemical potential provides information on the phase diagram of QCD with real chemical potential. With imaginary chemical potential $i\\mu_I=i\\pi T$, previous studies show that the Roberge-Weiss (RW) transition end points are triple points at both large and small quark masses, and second order transition points at intermediate quark masses. The triple and second order end points are separated by two tricritical ones. We present simulations with $ N_f=2 $ Wilson fermions to investigate the nature of RW transition end points. The simulations are carried out at 8 values of the hopping parameter $\\kappa$ ranging from 0.020 to 0.140 on different lattice volumes. The Binder cumulant, susceptibility and reweighted distribution of the imaginary part of Polyakov loop are employed to determine the nature of RW transition end points. The simulations show that the two tricritical points are within the range $0.070-0.080$ and $0.120-0.140$, respectively.

  20. Measurement of the F2n/F2p and d/u Ratios in Deep Inelastic Electron Scattering off 3H and 3He

    E-Print Network [OSTI]

    G. G. Petratos; I. R. Afnan; F. Bissey; J. Gomez; A. T. Katramatou; W. Melnitchouk; A. W. Thomas

    2000-10-19T23:59:59.000Z

    We discuss a possible measurement of the ratio of the nucleon structure functions, F2n/F2p, and the ratio of the up to down quark distributions, u/d, at large x, by performing deep inelastic electron scattering from the 3H and 3He mirror nuclei with the 11 GeV upgraded beam of Jefferson Lab. The measurement is expected to be almost free of nuclear effects, which introduce a significant uncertainty in the extraction of these two ratios from deep inelastic scattering off the proton and deuteron. The results are expected to test perturbative and non-perturbative mechanisms of spin-flavor symmetry breaking in the nucleon, and constrain the structure function parameterizations needed for the interpretation of high energy e-p, p-p and p-pbar collider data. The precision of the expected data can also allow for testing competing parameterizations of the nuclear EMC effect and provide valuable constraints on models of its dynamical origin.

  1. Lattice NRQCD study of S- and P-wave bottomonium states in a thermal medium with $N_f=2+1$ light flavors

    E-Print Network [OSTI]

    Seyong Kim; Peter Petreczky; Alexander Rothkopf

    2014-09-12T23:59:59.000Z

    We investigate the properties of S-and P-wave bottomonium states in the vicinity of the deconfinement transition temperature. The light degrees of freedom are represented by dynamical lattice QCD configurations of the HotQCD collaboration with $N_f = 2 + 1$ flavors. Bottomonium correlators are obtained from bottom quark propagators, computed in Non-Relativistic QCD (NRQCD) under the background of these gauge field configurations. The spectral functions for the $^3S_1$ ($\\Upsilon$) and $^3P_1$ ($\\chi_{b1}$) channel are extracted from the Euclidean time correlators using a novel Bayesian approach in the temperature region $140 {\\rm MeV} \\le T \\le 249 {\\rm MeV}$ and the results are contrasted to those from the standard Maximum Entropy Method. We find that the new Bayesian approach is far superior to the Maximum Entropy Method and enables us to study reliably the first peak in the spectral functions even under the limitations present in the finite temperature setup. We find that $\\chi_{b1}$ survives up to $T=249 {\\rm MeV}$, the highest temperature considered in our study and put stringent constraints on the size of the medium modification of $\\Upsilon$ and $\\chi_{b1}$ states.

  2. Identity and Access Management: Access Management Survey 1 Access Management Survey Questions

    E-Print Network [OSTI]

    Maroncelli, Mark

    Identity and Access Management: Access Management Survey 1 Access Management Survey Questions has developed a survey to solicit your input for Access Management. Please take a moment to complete be submitted by Friday May 14, 2010. #12;Identity and Access Management: Access Management Survey 2 Group

  3. Sustainable Energy Management Programs

    E-Print Network [OSTI]

    Hanner, S.

    2014-01-01T23:59:59.000Z

    Sustainable Energy Management Programs Steve Hanner Allen ISD/TEMA . ESL-KT-14-11-45 CATEE 2014: Clean Air Through Efficiency Conference, Dallas, Texas Nov. 18-20 Starting an Energy Management Program • Recognize need, Elicit District Commitment... • Appoint Energy Manager • Analyze Existing Conditions • Develop Plan • Implement and Monitor Program ESL-KT-14-11-45 CATEE 2014: Clean Air Through Efficiency Conference, Dallas, Texas Nov. 18-20 Sustainable Programs Feature – District Commitment...

  4. Poultry Pest Management

    E-Print Network [OSTI]

    Tomberlin, Jeffery K.; Drees, Bastiaan M.

    2007-05-18T23:59:59.000Z

    sanitation program of manure manage- ment, water management and weed mowing. Keep the manure dry because wet manure pro- motes fl y breeding and inhibits benefi cial insect breeding. Other benefi cials in poultry manure include mites and beetles..., according to Pest Management Recommendations for Poultry, a publication by Cornell University and Penn State Cooperative Extension. Mites and beetles are major preda- tors in caged-layer operations. The macrochelid mite, Macrochelis muscaedo- mesticae...

  5. Corporate Energy Management Process

    E-Print Network [OSTI]

    Geiger, T.

    2013-01-01T23:59:59.000Z

    . May 21-24, 2013 Corporate Energy Management Process 2 ?Brief introduction to BASF ? BASF Corporate Energy Management ? Management Support ? Goals ? Continuous Improvement ? Best Practices ? Recognition ?Summary ESL-IE-13-05-25 Proceedings...-value products ? Intelligent, sustainable system solutions ? 2012 Sales: ?72.1 Billion ? Employees: 110,000 Company overview BASF ? The Chemical Company ESL-IE-13-05-25 Proceedings of the Thrity-Fifth Industrial Energy Technology Conference New Orleans, LA...

  6. Change Control Management Guide

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-29T23:59:59.000Z

    The Guide provides a suggested approach and uniform guidance for managing project and contract changes through applying the requirements of DOE O 413.3B. No cancellation.

  7. Advisory Committee Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-10-22T23:59:59.000Z

    The Manual provides detailed DOE requirements, responsibilities, processes, and procedures for the establishment, operation, and management of advisory committees. Cancels DOE M 510.1-1.

  8. Records Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-02-03T23:59:59.000Z

    The Order sets forth requirements and responsibilities for implementing and maintaining a cost-effective records management program throughout the Department of Energy.

  9. Records Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-26T23:59:59.000Z

    The Order sets forth requirements and responsibilities for establishing and maintaining a program for the efficient and economical management of records and information assets.

  10. Total Light Management

    Broader source: Energy.gov [DOE]

    Presentation covers total light management, and is given at the Spring 2010 Federal Utility Partnership Working Group (FUPWG) meeting in Providence, Rhode Island.

  11. Enterprise Risk Management Framework

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Framework The Enterprise Risk Management (ERM) framework includes four steps: identify the risks, determine the probability and impact of each one, identify controls that are...

  12. Maintenance and Veg Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Vegetation Management on Forest Service Lands in Colorado, Nebraska and Utah Draft Environmental Impact Statement, DOEEIS-0442Project Description Western Area Power...

  13. About CRSP Management Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    assist customers in saving their valuable electrical resources by actively promoting energy management and conservation programs and helping them determine their future energy...

  14. Hydro Capital Asset Manager

    Broader source: Energy.gov [DOE]

    This position is located in Federal Hydro Projects, Generation Asset Management, Power Services. Additional vacancies may be filled through this vacancy announcement or if they become available.

  15. Energy, Data Management, Reporting

    Broader source: Energy.gov (indexed) [DOE]

    Design the Strategy | Deliver Efficiency | Sustain Results Energy, Data Management, Reporting This presentation does not contain any proprietary, confidential, or otherwise...

  16. Information Technology Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2013-11-21T23:59:59.000Z

    This revised Order is needed to clarify the roles and responsibilities, policies, and procedures for effectively managing IT investments to ensure mission success.

  17. Radioactive Waste Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1984-02-06T23:59:59.000Z

    To establish policies and guidelines by which the Department of Energy (DOE) manages tis radioactive waste, waste byproducts, and radioactively contaminated surplus facilities.

  18. International Commitments Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-11-18T23:59:59.000Z

    This Order establishes a process to manage the Department's International Commitments under the administrative direction of the Office of Policy and International Affairs. No cancellation.

  19. Project Management Practices

    Office of Environmental Management (EM)

    and applies it as the foundational, best case probability of occurrence. 2. 2. As applied to forecasting, planning, estimating in management: anchoring is a starting point,...

  20. Management Control Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2002-04-18T23:59:59.000Z

    To establish requirements and responsibilities for the Department of Energy Management Control Program. Cancels DOE O 413.1. Canceled by DOE O 413.1B.

  1. Water Management Act (Massachusetts)

    Broader source: Energy.gov [DOE]

    This Act regulates and registers water withdrawals in the Commonwealth of Massachusetts to enable effective planning and management of water use and conservation. The Act establishes a Water...

  2. Hazardous Wastes Management (Alabama)

    Broader source: Energy.gov [DOE]

    This legislation gives regulatory authority to the Department of Environmental Management to monitor commercial sites for hazardous wastes; fees on waste received at such sites; hearings and...

  3. Hazardous Waste Management (Indiana)

    Broader source: Energy.gov [DOE]

    The state supports the implementation of source reduction, recycling, and other alternative solid waste management practices over incineration and land disposal. The Department of Environmental...

  4. Solid Waste Management (Indiana)

    Broader source: Energy.gov [DOE]

    The state supports the implementation of source reduction, recycling, and other alternative solid waste management practices over incineration and land disposal. The Indiana Department of...

  5. Energy Management Systems

    E-Print Network [OSTI]

    Ferland, K.

    2007-01-01T23:59:59.000Z

    This presentation will address results from a pilot project with 10 chemical plants on energy management systems and the development of an energy efficiency plant certification program....

  6. Efficient Water Use & Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Water Use Goal 4: Efficient Water Use & Management Aware of the arid climate of northern New Mexico, water reduction and conservation remains a primary concern at LANL. Energy...

  7. Legacy Management Specific Training

    Broader source: Energy.gov [DOE]

    The following courses are specific to Legacy Management Employees, for more information about the courses below or to register for any of these courses please contact Chequita Johnson.

  8. Groundwater Management Areas (Texas)

    Broader source: Energy.gov [DOE]

    This legislation authorizes the Texas Commission on Environmental Quality and the Texas Water Development Board to establish Groundwater Management Areas to provide for the conservation,...

  9. Stormwater Management (North Carolina)

    Broader source: Energy.gov [DOE]

    The rules in this Section set forth the requirements for application and issuance of permits for stormwater management systems. These requirements to control pollutants associated with stormwater...

  10. Acquisition Career Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-05-14T23:59:59.000Z

    The order sets forth requirements and responsibilities for the Department of Energy (DOE) Acquisition Career Management Program. Cancels DOE O 361.1B.

  11. ISSUES MANAGEMENT PROGRAM MANUAL

    E-Print Network [OSTI]

    Gravois, Melanie

    2007-01-01T23:59:59.000Z

    LBNL/PUB-5519 (1), Rev. 032 ISSUES MANAGEMENT PROGRAM MANUAL LBNL/PUB-5519 (1), Rev.Berkeley National Laboratory LBNL/PUB-5519 (1), Rev. 0

  12. Site Office Manager, Princeton

    Broader source: Energy.gov [DOE]

    A successful candidate in this position will serve as the Princeton Site Office (PSO) Manager by providing overall executive leadership to the PSO.

  13. ORISE: Emergency Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    provided direction and experienced leadership to the Federal Bureau of Investigation's (FBI) Crisis Management Unit to establish a standardized exercise program for the FBI that...

  14. Parallel integrated thermal management

    DOE Patents [OSTI]

    Bennion, Kevin; Thornton, Matthew

    2014-08-19T23:59:59.000Z

    Embodiments discussed herein are directed to managing the heat content of two vehicle subsystems through a single coolant loop having parallel branches for each subsystem.

  15. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2005-11-02T23:59:59.000Z

    The Order establishes policy and assigns roles and responsibilities for the Department of Energy (DOE) Emergency Management System. Cancels DOE O 151.1B.

  16. Management and Performance NASA'S APPROACH TO PERFORMANCE MANAGEMENT

    E-Print Network [OSTI]

    Waliser, Duane E.

    TO PERFORMANCE MANAGEMENT conduct the Agency's day-to-day work. Figure 1 depicts NASA's organizational structureManagement and Performance NASA'S APPROACH TO PERFORMANCE MANAGEMENT NASA's FY 2015 Management as an organization and NASA's approach to performance management, strategic planning, and performance reporting

  17. Graph Databases for Large-Scale Healthcare Systems: A Framework for Efficient Data Management and Data Services

    SciTech Connect (OSTI)

    Park, Yubin [University of Texas at Austin] [University of Texas at Austin; Shankar, Mallikarjun [ORNL] [ORNL; Park, Byung H [ORNL] [ORNL; Ghosh, Dr. Joydeep [University of Texas at Austin] [University of Texas at Austin

    2014-01-01T23:59:59.000Z

    Designing a database system for both efficient data management and data services has been one of the enduring challenges in the healthcare domain. In many healthcare systems, data services and data management are often viewed as two orthogonal tasks; data services refer to retrieval and analytic queries such as search, joins, statistical data extraction, and simple data mining algorithms, while data management refers to building error-tolerant and non-redundant database systems. The gap between service and management has resulted in rigid database systems and schemas that do not support effective analytics. We compose a rich graph structure from an abstracted healthcare RDBMS to illustrate how we can fill this gap in practice. We show how a healthcare graph can be automatically constructed from a normalized relational database using the proposed 3NF Equivalent Graph (3EG) transformation.We discuss a set of real world graph queries such as finding self-referrals, shared providers, and collaborative filtering, and evaluate their performance over a relational database and its 3EG-transformed graph. Experimental results show that the graph representation serves as multiple de-normalized tables, thus reducing complexity in a database and enhancing data accessibility of users. Based on this finding, we propose an ensemble framework of databases for healthcare applications.

  18. Information Records Information Management (RIM)

    E-Print Network [OSTI]

    Alpay, S. Pamir

    10/2012 Records & Information Management (RIM) Records Information Management (RIM) encompasses all, and properly manage all records from creation to disposition. Record Management Strategies Lock your offices, and properly destroy when the record retention period is met. Establish a plan for how to manage and protect

  19. Information Collection Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-10-11T23:59:59.000Z

    This Order sets forth DOE requirements and responsibilities for implementing the information collection management provisions of the Paperwork Reduction Act of 1995 and the Office of Management and Budgets implementing regulation Controlling Paperwork Burdens on the Public, as contained in 5 CFR 1320. No cancellation.

  20. Risk Management Guide

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-09-16T23:59:59.000Z

    This Guide provides a framework for identifying and managing key technical, schedule, and cost risks through applying the requirements of DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, dated 7-28-06. Canceled by DOE G 413.3-7A, dated 1-12-11. Does not cancel other directives.

  1. BUILDING MANAGEMENT & RESTRICTED ACCESS

    E-Print Network [OSTI]

    Johnston, Daniel

    BUILDING MANAGEMENT & RESTRICTED ACCESS Plan Annex 2014 VIII #12;#12;#12;The University of Texas at Austiniv #12;Building Management & Restricted Access Plan Annex v CONTENTS RECORD OF CHANGES .......................................................................................................15 J. BUILDING SECURITY OPERATIONS RESTRICTED ACCESS PROCEDURES FOR BUILDINGS ON ELECTRONIC ACCESS

  2. Forest management certification

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    to the Montreal Process, certification systems lay out a set of criteria for sustainable management. Consumers. Each captures unique aspects of forestry and natural- resources management, offers indoor and outdoor.va.nrcs.usda.gov NRCS's natural resources conservation programs help people reduce soil erosion, enhance water supplies

  3. HAZARDOUS WASTE MANAGEMENT REFERENCE

    E-Print Network [OSTI]

    Faraon, Andrei

    Principal Investigators 7 Laboratory Personnel 8 EH&S Personnel 8 HAZARDOUS WASTE ACCUMULATION AREAS 9 Satellite Accumulation Area 9 Waste Accumulation Facility 10 HAZARDOUS WASTE CONTAINER MANAGEMENT LabelingHAZARDOUS WASTE MANAGEMENT REFERENCE GUIDE Prepared by Environment, Health and Safety Office

  4. Managing Soybean Insects.

    E-Print Network [OSTI]

    Drees, Bastiaan M.; Way, Michael O.

    1988-01-01T23:59:59.000Z

    defoliating beetles, grasshq>pers or pod-feeding stink bugs. Use of products containing Bacillus thuringiensis re quires a different approach to insect pest management. It is rather slow acting, is much more effective on smaller worms, and performs much... TABLE OF CONTENTS Page Pest ManageDlent Principles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Variety Selection...

  5. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-11-01T23:59:59.000Z

    To establish policy and to assign and describe roles and responsibilities for the Department of Energy (DOE) Emergency Management System. The Emergency Management System provides the framework for development, coordination, control, and direction of all emergency planning, preparedness, readiness assurance, response, and recovery actions. Canceled by DOE O 151.1B. Cancels DOE O 151.1.

  6. Hazardous Waste Management Training

    E-Print Network [OSTI]

    Dai, Pengcheng

    records. The initial training of Hazardous Waste Management and Waste Minimization is done in a classHazardous Waste Management Training Persons (including faculty, staff and students) working before handling hazardous waste. Departments are re- quired to keep records of training for as long

  7. Energy Management Webinar Series

    Broader source: Energy.gov [DOE]

    Boost your knowledge on how to implement an energy management system through this four-part webinar series from the Superior Energy Performance program. Each webinar introduces various elements of the ISO 50001 energy management standard—based on the Plan-Do-Check-Act approach—and the associated steps of DOE's eGuide for ISO 50001 software tool.

  8. OPERATIONS MANAGEMENT Spring 2008

    E-Print Network [OSTI]

    Almor, Amit

    the operations and supply chain strategy. This survey course in operations management introduces students1 MGSC 395 OPERATIONS MANAGEMENT Spring 2008 Course Syllabus Instructor: Professor Anand Nair Class MATERIALS Required Text Books Textbook: Krajewski, Lee, Ritzman, Larry, and Malhotra, Manoj. Operations

  9. Leptonic decay constants fK, fD and fDs with Nf = 2+1+1 twisted-mass lattice QCD

    E-Print Network [OSTI]

    N. Carrasco; P. Dimopoulos; R. Frezzotti; P. Lami; V. Lubicz; F. Nazzaro; E. Picca; L. Riggio; G. C. Rossi; F. Sanfilippo; S. Simula; C. Tarantino

    2015-02-25T23:59:59.000Z

    We present a lattice QCD calculation of the pseudoscalar decay constants fK, fD and fDs performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their values in the real world. The simulations are based on a unitary setup for the two light mass-degenerate quarks and on a mixed action approach for the strange and charm quarks. We use data simulated at three different values of the lattice spacing in the range 0.06 - 0.09 fm and at pion masses in the range 210 - 450 MeV. Our main results are: fK+ / fpi+ = 1.184 (16), fK+ = 154.4 (2.0) MeV, which incorporate the leading strong isospin breaking correction due to the up- and down-quark mass difference, and fK = 155.0 (1.9) MeV, fD = 207.4 (3.8) MeV, fDs = 247.2 (4.1) MeV, fDs / fD = 1.192 (22) and (fDs / fD) / (fK / fpi) = 1.003 (14) obtained in the isospin symmetric limit of QCD. Combined with the experimental measurements of the leptonic decay rates of kaon, pion, D- and Ds-mesons our results lead to the following determination of the CKM matrix elements: |Vus| = 0.2269 (29), |Vcd| = 0.2221 (67) and |Vcs| = 1.014 (24). Using the latest value of |Vud| from superallowed nuclear beta decays the unitarity of the first row of the CKM matrix is fulfilled at the permille level.

  10. DRAFT Fifteenmile Management Plan 5. Fifteenmile Subbasin Management Plan

    E-Print Network [OSTI]

    DRAFT Fifteenmile Management Plan 5. Fifteenmile Subbasin Management Plan DRAFT May 25 2004 Group 5. FIFTEENMILE SUBBASIN MANAGEMENT PLAN............................................... 38 5.5.2. Consistency with the Clean Water Act, Total Maximum Daily Loads and Existing Water Quality

  11. PIA - Environmental Management Consolidated Business Center ...

    Office of Environmental Management (EM)

    Management Consolidated Business Center (EMCBC) PIA - Environmental Management Consolidated Business Center (EMCBC) PIA - Environmental Management Consolidated Business Center...

  12. LRRB Pavement Management Systems Pavement Management Systems

    E-Print Network [OSTI]

    Minnesota, University of

    Survey: who is using what · Details about specific software/use · Case studies #12;Report (continued) Key Outcome ­ Matrix #12;Report (continued) Key Outcome ­ Case Studies (15 agencies) § Various levels of use Pavement Management Systems Workshop outline 1. Overview 2. Benefits 3. Elements 4. Case Studies 5

  13. Line Management Perspective: Office of Environmental Management (EM)

    Broader source: Energy.gov [DOE]

    Slide Presentation by Matthew Moury, Deputy Assistant Secretary for Safety, Security and Quality Programs, Office of Environmental Management. EFCOG Integrated Safety Management Work Planning and Control.

  14. Weed Management Costs, Weed Best Management Practices, and The Roundup Ready Weed Management Program

    E-Print Network [OSTI]

    Mitchell, Paul D.

    substantially increase weed management costs and so discourage adoption. This paper uses survey results: glyphosate, resistance management, BMP adoption, telephone survey, herbicide #12;2 INTRODUCTION Roundup ReadyWeed Management Costs, Weed Best Management Practices, and The Roundup Ready® Weed Management

  15. Fleet Management | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Fleet management includes commercial and agency owned motor vehicles such as cars, vans, trucks, and buses. Fleet (vehicle) management at the headquarters level includes a range of...

  16. Georgia Hazardous Waste Management Act

    Broader source: Energy.gov [DOE]

    The Georgia Hazardous Waste Management Act (HWMA) describes a comprehensive, Statewide program to manage hazardous wastes through regulating hazardous waste generation, transportation, storage,...

  17. An Identity and Certificate Manager

    E-Print Network [OSTI]

    Wu, Brian C

    2007-01-01T23:59:59.000Z

    We have designed and implemented a software library, called Identity and Certificate Manager (ICM), for managing, using, and exchanging application-level usernames, users' digital certificates, and cryptographic ...

  18. Fleet Management | Department of Energy

    Energy Savers [EERE]

    DOE Fleet Management Contact your Fleet manager for access to these systems Federal Automotive Statistical Tool (FAST): Supports EPAct of 1992 requirements , the Energy...

  19. Asset management solutions To support your agency's mission

    E-Print Network [OSTI]

    readiness and accountability, including work management, inventory management, service management, contract and service management functions. Work management Inventory management Procurement management ServiceAsset management solutions To support your agency's mission IBM Maximo® Asset Management

  20. Secure Transportation Management

    SciTech Connect (OSTI)

    Gibbs, P. W. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-10-15T23:59:59.000Z

    Secure Transport Management Course (STMC) course provides managers with information related to procedures and equipment used to successfully transport special nuclear material. This workshop outlines these procedures and reinforces the information presented with the aid of numerous practical examples. The course focuses on understanding the regulatory framework for secure transportation of special nuclear materials, identifying the insider and outsider threat(s) to secure transportation, organization of a secure transportation unit, management and supervision of secure transportation units, equipment and facilities required, training and qualification needed.

  1. Radioactive Waste Management Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09T23:59:59.000Z

    This Manual further describes the requirements and establishes specific responsibilities for implementing DOE O 435.1, Radioactive Waste Management, for the management of DOE high-level waste, transuranic waste, low-level waste, and the radioactive component of mixed waste. The purpose of the Manual is to catalog those procedural requirements and existing practices that ensure that all DOE elements and contractors continue to manage DOE's radioactive waste in a manner that is protective of worker and public health and safety, and the environment. Does not cancel other directives.

  2. Conservation and drought management 

    E-Print Network [OSTI]

    Finch, Calvin

    2012-01-01T23:59:59.000Z

    management are related, but they are not the same. Water conservation is a long-term e#27;ort to reduce the amount of water it takes to manufacture goods, manage households and care for landscapes. Drought management is water-use rules initiated to deal... using less water comes only if people caring for the landscape choose to use the right amount of water at the right time to take advantage of the plants? capabilities. Water purveyors can conserve water with good maintenance and leak repair...

  3. Information Technology Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-12-23T23:59:59.000Z

    The Order identifies the objectives, components, and responsibilities for implementing processes to ensure the effective management of information and information systems within the Department. Cancels DOE O 200.1.

  4. Management of Nuclear Materials

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1994-05-26T23:59:59.000Z

    To establish requirements and procedures for the management of nuclear materials within the Department of Energy (DOE). Cancels DOE 5660.1A. Canceled by DOE O 410.2.

  5. Resources for Fleet Managers

    Broader source: Energy.gov [DOE]

    Fleet managers will benefit from the lower fuel costs, more reliable fuel prices, and lower emissions that come from using alternative fuels and advanced technologies made possible through the work...

  6. APS Building Managers

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Building Managers BUILDING CONTACT 400,401,402,411,412,413,415,420,431-436,438 Steven Downey 450 Glenn Kailus 382 Joe Gagliano 378 Ed Theres 314 Ed Russell...

  7. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    EVM Systems: Post CD-3, (greater than 20 million). 95%* 94% EVM represents Earned Value Management. Certified FPD's at CD-1: Projects have certified FPDs no later than CD-1....

  8. Contract/Project Management

    Energy Savers [EERE]

    EVM Systems: Post CD-3, (greater than 20 million). 95%* 98% EVM represents Earned Value Management. Certified FPD's at CD-1: Projects have certified FPDs no later than CD-1....

  9. Contract/Project Management

    Office of Environmental Management (EM)

    EVM Systems: Post CD-3, (greater than 20 million). 95%* 100% EVM represents Earned Value Management. Certified FPD's at CD-1: Projects have certified FPDs no later than CD-1....

  10. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EVM Systems: Post CD-3, (greater than 20 million). 95%* 96% EVM represents Earned Value Management. Certified FPD's at CD-1: Projects have certified FPDs no later than CD-1....

  11. Project Management Lessons Learned

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-08-05T23:59:59.000Z

    The guide supports DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, and aids the federal project directors and integrated project teams in the execution of projects.

  12. Human Resource Management Delegation

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-06-28T23:59:59.000Z

    The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

  13. Load Management Made Simple

    E-Print Network [OSTI]

    Schneider, K.

    1985-01-01T23:59:59.000Z

    Up until the 1970's electric utilities were basically in a supply side management mode, in which plants were built to serve whatever demand customers required. However in the last 10- 15 years, many utilities, including Texas Utilities Electric...

  14. Manager, Carlsbad Field Office

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy (DOE), Office of Environmental Management (EM), Carlsbad Field Office (CBFO) is seeking a highly experienced and motivated executive-minded individual to fill its...

  15. Office of Information Management

    Broader source: Energy.gov [DOE]

    The Office of Information Management provides a broad range of information technology services in support of the Associate Under Secretary for the Office of Environment, Health, Safety and Security (AU).

  16. Lawn Water Management 

    E-Print Network [OSTI]

    McAfee, James

    2006-06-26T23:59:59.000Z

    Water is a limited resource in Texas. This booklet explains how homeowners can establish a water management program for a home lawn that both maintains a healthy sod and also conserves water. The publication discusses soil types, grass varieties...

  17. Hazardous Waste Management (Arkansas)

    Broader source: Energy.gov [DOE]

    The Hazardous Waste Program is carried out by the Arkansas Department of Environmental Quality which administers its' program under the Hazardous Waste management Act (Arkansas Code Annotated 8-7...

  18. Hazardous Waste Management (Delaware)

    Broader source: Energy.gov [DOE]

    The act authorizes the Delaware Department of Natural Resources and Environment Control (DNREC) to regulate hazardous waste and create a program to manage sources of hazardous waste. The act...

  19. Solid Waste Management (Kansas)

    Broader source: Energy.gov [DOE]

    This act aims to establish and maintain a cooperative state and local program of planning and technical and financial assistance for comprehensive solid waste management. No person shall construct,...

  20. Lawn Water Management

    E-Print Network [OSTI]

    McAfee, James

    2006-06-26T23:59:59.000Z

    Water is a limited resource in Texas. This booklet explains how homeowners can establish a water management program for a home lawn that both maintains a healthy sod and also conserves water. The publication discusses soil types, grass varieties...

  1. Headquarters Personal Property Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-10-25T23:59:59.000Z

    To establish procedures for managing Government personal property owned or leased by the Department of Energy and in the custody of DOE Headquarters employees, including those in the National Nuclear Security Administration. Cancels DOE HQ O 580.1A

  2. "Managing Department Climate Change"

    E-Print Network [OSTI]

    Sheridan, Jennifer

    "Managing Department Climate Change" #12;Presenters · Ronda Callister Professor, Department Department Climate? · Assesment is essential for determining strategies for initiating change · In a research climate · Each panelist will describe an intervention designed to improve department climate ­ Ronda

  3. Groundwater Protection Management Program

    SciTech Connect (OSTI)

    Wells, D.G.

    1999-10-20T23:59:59.000Z

    This document will be a useful reference for those engaged in groundwater protection and management. This document presents a great deal of detail while still addressing the larger issues.

  4. Transportation Management Workshop: Proceedings

    SciTech Connect (OSTI)

    Not Available

    1993-10-01T23:59:59.000Z

    This report is a compilation of discussions presented at the Transportation Management Workshop held in Gaithersburg, Maryland. Topics include waste packaging, personnel training, robotics, transportation routing, certification, containers, and waste classification.

  5. Facility Manager Primary Purpose

    E-Print Network [OSTI]

    Saskatchewan, University of

    for required goods or services to achieve maximum value for money; b. managing supplier/contractor performance, including employee qualifications, training and developing staff, performance evaluation, and related areas

  6. Streamside Management Zones (Montana)

    Broader source: Energy.gov [DOE]

    This chapter sets streamside management zones as encompassing a strip at least 50 feet wide on each side of a stream, lake, or other body of water, measured from the ordinary high-water mark, and...

  7. Strategic Energy Management

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy (DOE) See Action Network and Weatherization and Intergovernmental Program Technical Assistance Program sponsored this webinar about strategic management in the public sector on November 7, 2012.

  8. Towards CORBAbased Enterprise Management: Managing CORBAbased Systems with SNMP Platforms

    E-Print Network [OSTI]

    of different management architectures. The aim of the work described in this paper con­ sists in helping1 Towards CORBA­based Enterprise Management: Managing CORBA­based Systems with SNMP Platforms, CA, USA, November 1998 Abstract--- Apart from the well established OSI/TMN and Internet management

  9. Annex 2 Risk Management Guidance and Template SPO Project Management

    E-Print Network [OSTI]

    1 Annex 2 ­ Risk Management Guidance and Template SPO Project Management Guidance on Risk Management Introduction Risk is any action or event that affects a project's ability to achieve its on cost, schedule and technical performance. However, with appropriate procedures, risks can be managed

  10. Information Technology and Management Department of Information Technology and Management

    E-Print Network [OSTI]

    Heller, Barbara

    Information Technology and Management Department of Information Technology and Management Daniel F Chicago, IL 60616 appliedtech.iit.edu/information-technology-and- management Dean and Chair: C. Robert in the information technology and cyber security fields. The Information Technology and Management degrees apply

  11. Archives & Records Management Bulletin UW-Madison Records Management Program

    E-Print Network [OSTI]

    Sheridan, Jennifer

    1 Archives & Records Management Bulletin UW-Madison Records Management Program A Periodical Responsibilities and University Records Information technology has effectively made all of us records managers. The Campus Records Review Group and University Records Management Program are concerned and would like

  12. Evolution and Evaluation of the Active Management Area Management Plans

    E-Print Network [OSTI]

    Fay, Noah

    Evolution and Evaluation of the Active Management Area Management Plans FINAL January 2008 Sharon B with a grant from the Arizona Water Institute and by the Arizona Department of Water Resources #12;Evolution 1 Methodology 2 Management Plan Purpose and Intent 4 Evolution and Evaluation of the Management Plan

  13. Radioactive Waste Management Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09T23:59:59.000Z

    This Manual further describes the requirements and establishes specific responsibilities for implementing DOE O 435.1, Radioactive Waste Management, for the management of DOE high-level waste, transuranic waste, low-level waste, and the radioactive component of mixed waste. Change 1 dated 6/19/01 removes the requirement that Headquarters is to be notified and the Office of Environment, Safety and Health consulted for exemptions for use of non-DOE treatment facilities. Certified 1-9-07.

  14. Lithium battery management system

    DOE Patents [OSTI]

    Dougherty, Thomas J. (Waukesha, WI)

    2012-05-08T23:59:59.000Z

    Provided is a system for managing a lithium battery system having a plurality of cells. The battery system comprises a variable-resistance element electrically connected to a cell and located proximate a portion of the cell; and a device for determining, utilizing the variable-resistance element, whether the temperature of the cell has exceeded a predetermined threshold. A method of managing the temperature of a lithium battery system is also included.

  15. Feed Feeds: Managing Feeds Using Feeds

    E-Print Network [OSTI]

    Wilde, Erik; Pesenson, Igor

    2008-01-01T23:59:59.000Z

    standards can be used to manage feed metadata, making feed management available through an established API.

  16. Project Management Plan Chinese Food

    E-Print Network [OSTI]

    Igusa, Kiyoshi

    impact of this project? · Data management: How do we collect, preserve and sort all of the files? Which special equipment, facilities needed or wanted? According to http://project-management-knowledge.com/ weProject Management Plan Chinese Food According to NSF, the basic elements of a project management

  17. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT ANNUAL REPORT January 2008 OFFICE OF UNIVERSITY RISK MANAGEMENT CP-320 714-278-7346 #12;2006 ­ 2007 Risk Management Annual Report Page 2 I. Executive Summary A. Program Cost One method to assess the effectiveness of the University's risk management

  18. Eighth Annual Risk Management Conference

    E-Print Network [OSTI]

    Chaudhuri, Sanjay

    Eighth Annual Risk Management Conference Risk Management Amidst Global Rebalancing 10 ­ 11 July 2014, Singapore The Risk Management Institute (RMI) at the National University of Singapore invites submissions for its 8th annual conference on risk management in Singapore on 10 and 11 July 2014. We

  19. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT ANNUAL REPORT November 2006 OFFICE OF UNIVERSITY RISK MANAGEMENT LH-806C 714-278-7346 #12;2005 ­ 2006 Risk Management Annual Report Page 2 I. Executive Summary A. Program Cost One method to assess the effectiveness of the University's risk management

  20. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT ANNUAL REPORT November 2005 OFFICE OF UNIVERSITY RISK MANAGEMENT LH-806C 714-278-7346 #12;2004 ­ 2005 Risk Management Annual Report Page 2 I. Introduction The Office of University Risk Management provides resources, advice and training that allow

  1. Assistant Director, Prospect Management Description

    E-Print Network [OSTI]

    Portman, Douglas

    and to the Prospect Management Data Wranglers to assist their efforts in improving the quality of Prospect Management Management · Enter and monitor prospect assignments and new prospect records requests. · Monitor data quality of all functions and systems related to prospect management, including software applications, industry

  2. Energy Management Issued: June 2010

    E-Print Network [OSTI]

    Energy Management Policy Issued: June 2010 Revised: Responsible Administrative Unit: Finance.0 BACKGROUND AND PURPOSE The Engineering and Energy Management division of the Department of Facilities Management at the Colorado School of Mines ("Mines" or "the school") has developed an Energy Management

  3. Information & Records Management Process Manual

    E-Print Network [OSTI]

    Hickman, Mark

    several significant failures to manage information in the public sector in New Zealand, which the Official Information, Privacy, Copyright and Public Records Acts. How you manage UC informationInformation & Records Management Process Manual 2013Information and Records Management #12;Contents

  4. PRINCIPLES OF ARCHIVES & RECORDS MANAGEMENT

    E-Print Network [OSTI]

    New Mexico, University of

    PRINCIPLES OF ARCHIVES & RECORDS MANAGEMENT Archives and records management is based upon." The basic unit used in all discussions of records management and all records retention and disposi- tion of a record series is known as "appraisal," the second basic principle of records management. Appraisal

  5. RECYCLING AND GENERAL WASTE MANAGEMENT OPERATIONAL PROCEDURE

    E-Print Network [OSTI]

    Harman, Neal.A.

    RECYCLING AND GENERAL WASTE MANAGEMENT OPERATIONAL PROCEDURE Swansea University Estates Services.6.1/1 Recycling & General Waste Management Department: Estates & Facilities Management Site: Swansea University recycling and waste management facilities in Swansea university To ensure that Waste Management Objectives

  6. The REMOTE SENSlNf

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling7 AugustAFRICAN3uj: ;;IDEC. i' , i Department_''1

  7. UNC Charlotte Government Property Management Plan 1 Government Property Management Plan

    E-Print Network [OSTI]

    Howitt, Ivan

    . MANAGEMENT AND ACQUISITION Under the University's property management system, the Materials ManagementUNC Charlotte Government Property Management Plan 1 Government Property Management Plan Initially approved: 21 October 2011 Updated: August 24, 2012 SCOPE This Government Property Management Plan applies

  8. Certified records manager exam

    SciTech Connect (OSTI)

    Not Available

    1990-01-01T23:59:59.000Z

    The Institute of Certified Records Managers (ICRM) is a non-profit, certifying organization of professional records managers and administrators. ICRM members are experienced in information requirements, records and information systems, and the related office systems and technologies. All members have met certification requirements and have received the Certified Records Manager (CRM) designation. As the field of information and records management moves toward standardization, and as the application of new technologies and technicalities complicate the measurement and demonstration of professional competence, the need for a means of identifying persons who have basic competency increases. The ICRM is providing such a means by testing and certifying basic knowledge. More and more job announcements are requiring this evidence of competency. Unfortunately, as an organization, NIRMA has a relatively small number of CRMs. The goal of the ICRM Development Group is two-fold; (1) to encourage NIRMA members to obtain their certification by providing basic information and support and; (2) to develop the Nuclear Specialist test module which will demonstrate that bearers have demonstrated expertise in nuclear records management as well as basic competencies. This report covers the examination process.

  9. Oil field management system

    DOE Patents [OSTI]

    Fincke, James R.

    2003-09-23T23:59:59.000Z

    Oil field management systems and methods for managing operation of one or more wells producing a high void fraction multiphase flow. The system includes a differential pressure flow meter which samples pressure readings at various points of interest throughout the system and uses pressure differentials derived from the pressure readings to determine gas and liquid phase mass flow rates of the high void fraction multiphase flow. One or both of the gas and liquid phase mass flow rates are then compared with predetermined criteria. In the event such mass flow rates satisfy the predetermined criteria, a well control system implements a correlating adjustment action respecting the multiphase flow. In this way, various parameters regarding the high void fraction multiphase flow are used as control inputs to the well control system and thus facilitate management of well operations.

  10. Uranium Mill Tailings Management

    SciTech Connect (OSTI)

    Nelson, J.D.

    1982-01-01T23:59:59.000Z

    This book presents the papers given at the Fifth Symposium on Uranium Mill Tailings Management. Advances made with regard to uranium mill tailings management, environmental effects, regulations, and reclamation are reviewed. Topics considered include tailings management and design (e.g., the Uranium Mill Tailings Remedial Action Project, environmental standards for uranium mill tailings disposal), surface stabilization (e.g., the long-term stability of tailings, long-term rock durability), radiological aspects (e.g. the radioactive composition of airborne particulates), contaminant migration (e.g., chemical transport beneath a uranium mill tailings pile, the interaction of acidic leachate with soils), radon control and covers (e.g., radon emanation characteristics, designing surface covers for inactive uranium mill tailings), and seepage and liners (e.g., hydrologic observations, liner requirements).

  11. Computer memory management system

    DOE Patents [OSTI]

    Kirk, III, Whitson John (Greenwood, MO)

    2002-01-01T23:59:59.000Z

    A computer memory management system utilizing a memory structure system of "intelligent" pointers in which information related to the use status of the memory structure is designed into the pointer. Through this pointer system, The present invention provides essentially automatic memory management (often referred to as garbage collection) by allowing relationships between objects to have definite memory management behavior by use of coding protocol which describes when relationships should be maintained and when the relationships should be broken. In one aspect, the present invention system allows automatic breaking of strong links to facilitate object garbage collection, coupled with relationship adjectives which define deletion of associated objects. In another aspect, The present invention includes simple-to-use infinite undo/redo functionality in that it has the capability, through a simple function call, to undo all of the changes made to a data model since the previous `valid state` was noted.

  12. Radioactive Waste Management Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09T23:59:59.000Z

    This Manual further describes the requirements and establishes specific responsibilities for implementing DOE O 435.1, Radioactive Waste Management, for the management of DOE high-level waste, transuranic waste, low-level waste, and the radioactive component of mixed waste. Change 1 dated 6/19/01 removes the requirement that Headquarters is to be notified and the Office of Environment, Safety and Health consulted for exemptions for use of non-DOE treatment facilities. Certified 1-9-07. Admin Chg 2, dated 6-8-11, cancels DOE M 435.1-1 Chg 1.

  13. Earned Value Management

    E-Print Network [OSTI]

    Ferguson, J

    2002-01-01T23:59:59.000Z

    Earned Value Management is a methodology used to measure and communicate the real physical progress of a project and show its true cost situation. This tool was developed by the US Department of Defense in 1967 and later used successfully for monitoring DOE projects, in particular the US LHC accelerator project. A clear distinction must be made between an earned value management system and other tools under consideration or already existing at CERN which permit accurate predictions of the amount and date of future payments or a detailed follow up of contracts.

  14. Manage Your Time 

    E-Print Network [OSTI]

    White, Lynn

    2000-06-27T23:59:59.000Z

    , you expect unused time to come around again, so that when the same opportunities appear you will be wiser about how to use it. Consider how your cultural background af_fects the w ay you plan and manage time. W *Both cited in Bauer, J. It?s Time.... Effective time management means decid- ing which activity should be done from all the possibilities available, and then doing it. It is a matter of setting priorities. Deciding which jobs are most important and working on those may be better than doing less...

  15. NS&T MANAGEMENT OBSERVATIONS

    SciTech Connect (OSTI)

    Gianotto, David

    2014-06-01T23:59:59.000Z

    The INL Management Observation Program (MOP) is designed to improve managers and supervisors understanding of work being performed by employees and the barriers impacting their success. The MOP also increases workers understanding of managements’ expectations as they relate to safety, security, quality, and work performance. Management observations (observations) are designed to improve the relationship and trust between employees and managers through increased engagement and interactions between managers and researchers in the field. As part of continuous improvement, NS&T management took initiative to focus on the participation and quality of observations in FY 14. This quarterly report is intended to (a) summarize the participation and quality of management’s observations, (b) assess observations for commonalities or trends related to facility or process barriers impacting research, and (c) provide feedback and make recommendations for improvements NS&T’s MOP.

  16. Managing projects utilizing self-managed teams and managerial toolkits

    E-Print Network [OSTI]

    Mathur, Praveen, S. M. Massachusetts Institute of Technology

    2009-01-01T23:59:59.000Z

    Project Management is an essential function in most software companies today. With increasing complexity and inter connectivity between software projects, it is not surprising that managing such large scale development ...

  17. BEST PAPER PROCEEDING ACADEMY OF MANAGEMENT Technology and Innovation Management

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    BEST PAPER PROCEEDING ACADEMY OF MANAGEMENT Technology and Innovation Management Philadelphia, 6 FOURCADE ESCP-EAP, Paris ABSTRACT How firms combine incremental and radical innovation? The ambidextrous exploring new businesses and technologies (Dougherty, 1992 ; Leonard-Barton, 1992). Several organizational

  18. Integrated Safety Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-04-25T23:59:59.000Z

    The order ensures that DOE/NNSA, systematically integrates safety into management and work practices at all levels, so that missions are accomplished efficiently while protecting the workers, the public, and the environment. Cancels DOE M 450.4-1 and DOE M 411.1-1C

  19. Gas Cylinders: Proper Management

    E-Print Network [OSTI]

    Boyer, Elizabeth W.

    Compressed Gas Cylinders: Proper Management And Use Published by the Office of Environment, Health;1 Introduction University of California, Berkeley (UC Berkeley) departments that use compressed gas cylinders (MSDS) and your department's Job Safety Analyses (JSAs). Talk to your gas supplier about hands

  20. Integrated Safety Management Policy

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-04-25T23:59:59.000Z

    The policy establishes DOE's expectation for safety, including integrated safety management that will enable the Department’s mission goals to be accomplished efficiently while ensuring safe operations at all departmental facilities and activities. Cancels DOE P 411.1, DOE P 441.1, DOE P 450.2A, DOE P 450.4, and DOE P 450.7

  1. Comprehensive Irrigation Management 

    E-Print Network [OSTI]

    Cook, K.

    2011-01-01T23:59:59.000Z

    ? Commoditized relationships ? Disconnect with conservation investments & sustainable water savings ? High turnover rates among property managers and landscape contractors ? Economic pressures on operating expense to maintain system integrity Result... for conserving water ? Irrigation manufactures disputed claims regarding documentable savings ? Irrigation professionals blamed for excessive application ? Regulatory agencies not accountable ? Water utilities imposing restrictions & blaming landscapes...

  2. Facilities Management Field Services

    E-Print Network [OSTI]

    Hickman, Mark

    Facilities Management Field Services FieldStationsAnnualReport2006 #12;Cover Photo by Dr Mark Jermy coast #12; Introduction A very wet Steve Weaver emerges from the river. Ah, field work! The Government broadband, at least there is now an alternative to the telephone line. Electrical power spikes (and outages

  3. Position Management and Classification

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-04-01T23:59:59.000Z

    The order establishes departmental requirements and responsibilities for classifying positions using general schedule (GS) and federal wage system (FWS) standards and for developing and administering a sound position management and classification program within the Department. Cancels Chapter VII of DOE O 320.1.

  4. Purge water management system

    DOE Patents [OSTI]

    Cardoso-Neto, Joao E. (North Augusta, SC); Williams, Daniel W. (Aiken, SC)

    1996-01-01T23:59:59.000Z

    A purge water management system for effectively eliminating the production of purge water when obtaining a groundwater sample from a monitoring well. In its preferred embodiment, the purge water management system comprises an expandable container, a transportation system, and a return system. The purge water management system is connected to a wellhead sampling configuration, typically permanently installed at the well site. A pump, positioned with the monitoring well, pumps groundwater through the transportation system into the expandable container, which expands in direct proportion with volume of groundwater introduced, usually three or four well volumes, yet prevents the groundwater from coming into contact with the oxygen in the air. After this quantity of groundwater has been removed from the well, a sample is taken from a sampling port, after which the groundwater in the expandable container can be returned to the monitoring well through the return system. The purge water management system prevents the purge water from coming in contact with the outside environment, especially oxygen, which might cause the constituents of the groundwater to oxidize. Therefore, by introducing the purge water back into the monitoring well, the necessity of dealing with the purge water as a hazardous waste under the Resource Conservation and Recovery Act is eliminated.

  5. ENGINEERING MANAGEMENT AND LEADERSHIP

    E-Print Network [OSTI]

    Eagar, Thomas W.

    ENGINEERING MANAGEMENT AND LEADERSHIP Where did we come from? Where are we going? How do we get · If it works but no one knows why, it's ENGINEERING #12;The scientist explains that which exists; The engineer creates that which never was. Theodore von Karman #12;Engineer - Noun (from French "to contrive

  6. Radioactive Waste Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09T23:59:59.000Z

    The objective of this Order is to ensure that all Department of Energy (DOE) radioactive waste is managed in a manner that is protective of worker and public health and safety and the environment. Cancels DOE O 5820.2A. Chg 1 dated 8-28-01. Certified 1-9-07.

  7. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-10-29T23:59:59.000Z

    To establish policy and to assign and describe roles and responsibilities for the Department of Energy (DOE) Emergency Management System. (This is an administrative change to DOE O 151.1A). Canceled by DOE O 151.1C. Cancels DOE O 151.1A.

  8. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-08-21T23:59:59.000Z

    The Order establishes policy and assigns and describes roles and responsibilities for the DOE Emergency Management System. Cancels DOE 5500.1B, DOE 5500.2B, DOE 5500.3A, DOE 5500.4A, 5500.5A,5500.7B, 5500.8A, 5500.9A, DOE 5500.10

  9. Best Environmental Management Practices

    E-Print Network [OSTI]

    protection 3. Aesthetics Acceptable ways for managing mortality include: 1. Rendering 2. Composting 3, and composting methods recycle the nutrients. The other methods, in essence, waste the nutrients. Rendering by rendering plant vehicles and personnel. Composting Composting is the controlled aerobic biological

  10. Computing & Communications PROFILE MANAGEMENT

    E-Print Network [OSTI]

    Warkentin, Ian G.

    Computing & Communications PROFILE MANAGEMENT What is a profile? If you use a SWGC computing account, a profile will be created for you. A profile is a special file which is used to store your are provided with a default profile which is the same for all users. Any changes you then make to your working

  11. Radioactive Waste Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09T23:59:59.000Z

    The objective of this Order is to ensure that all Department of Energy (DOE) radioactive waste is managed in a manner that is protective of worker and public health and safety and the environment. Cancels DOE O 5820.2A

  12. Office of Quality Management

    Broader source: Energy.gov [DOE]

    The Office of Quality Management develops and interprets Government-wide policies and procedures and conducts training to ensure the accurate identification of information and documents that must be classified or controlled under statute or Executive order to protect the national security and controlled unclassified Official Use Only information for the effective operation of the Government.

  13. Managing environmental information

    SciTech Connect (OSTI)

    Solyst, J. [Chemical Manufacturers Association, Arlington, VA (United States)

    1998-12-31T23:59:59.000Z

    The public`s right to know about environmental policy has moved to the forefront with the technological advances in recent years. Congress has not kept pace with these developments having twice considered and twice rejected legislation that is necessary in this field. Congress should provide leadership to the Environmental Protection Agency (EPA) for a broad strategy to improve information resources and management.

  14. Purge water management system

    DOE Patents [OSTI]

    Cardoso-Neto, J.E.; Williams, D.W.

    1995-01-01T23:59:59.000Z

    A purge water management system is described for effectively eliminating the production of purge water when obtaining a groundwater sample from a monitoring well. In its preferred embodiment, the purge water management system comprises an expandable container, a transportation system, and a return system. The purge water management system is connected to a wellhead sampling configuration, typically permanently installed at the well site. A pump, positioned with the monitoring well, pumps groundwater through the transportation system into the expandable container, which expands in direct proportion with volume of groundwater introduced, usually three or four well volumes, yet prevents the groundwater from coming into contact with the oxygen in the air. After this quantity of groundwater has been removed from the well, a sample is taken from a sampling port, after which the groundwater in the expandable container can be returned to the monitoring well through the return system. The purge water management system prevents the purge water from coming in contact with the outside environment, especially oxygen, which might cause the constituents of the groundwater to oxidize. Therefore, by introducing the purge water back into the monitoring well, the necessity of dealing with the purge water as a hazardous waste under the Resource Conservation and Recovery Act is eliminated.

  15. Mobile Technology Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2014-05-15T23:59:59.000Z

    The order establishes requirements, assigns responsibilities, and provides guidance for federal mobile technology management and employee use of both government furnished and personally-owned mobile devices within DOE and NNSA. Establishes requirements for use of User Agreements to govern mobile devices used for official duties. Does not cancel other directives.

  16. A bank management audit

    E-Print Network [OSTI]

    Kennemer, Hoyt Granville

    1957-01-01T23:59:59.000Z

    . Bogle Letbetter for their assistance in the preparation of this thesis. Special acknowledgement is also extended to the exec- utives of the Blank Eational Bank foz their time and. co- operation in deueloplnp answers to the questions contained..., ~ ~ ~ 49 X EXECUTIVE EVALUATION w ~ ~ ~ ~ ~ ~ ~ ~ ~ 52 XI CCNCLUSION ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ BIBLIOGRAPHY ~ o APPENDIX ~ ~ ~ ~ 1 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ e ~ ~ ~ ~ 6) LIST OP CHAHTS Chart I, Organisation Chart of the Bank Manage- ment...

  17. Potassium & Potassium Management

    E-Print Network [OSTI]

    Balser, Teri C.

    Potassium & Potassium Management Carrie Laboski Department of Soil Science UW- Madison #12;Havlin Not irrigated #12;Environmental Factors Affecting K Availability to a Plant Soil moisture Low soil moisture moisture will increase K diffusion Increase soil moisture from 10 to 28 % can increase toatl K transport

  18. BSBA IN MANAGEMENT -HUMAN RESOURCE MANAGEMENT SPECIALIZATION ASSESSMENT PLAN

    E-Print Network [OSTI]

    Gallo, Linda C.

    BSBA IN MANAGEMENT - HUMAN RESOURCE MANAGEMENT SPECIALIZATION ASSESSMENT PLAN (REV. 7 in Human Resource Management (HRM), the goal is to provide a foundation of all areas of human resources countries. · Content Delivered in: MGT 350, MGT 405, & MGT 357. · Assessment Method: Culminating exam

  19. Project Management Plan Project Title: Natural Resources Management

    E-Print Network [OSTI]

    US Army Corps of Engineers

    DEFINITION. The NRM Gateway is a knowledge management resource, designed to serve the needs of the NRMP; · Preserve institutional knowledge; · Develop practical and agency-approved webpages that provide usefulProject Management Plan Project Title: Natural Resources Management (NRM) Gateway Website

  20. Information Technology and Management Information Technology and Management

    E-Print Network [OSTI]

    Heller, Barbara

    Information Technology and Management Information Technology and Management IIT School of Applied Technology Daniel F. and Ada L. Rice Campus 201 E. Loop Road Wheaton, IL 60187 www.iit.edu/applied tech/ Dean Technology & Management program is to educate and inform students to prepare them to assume technical

  1. Nutrient Management Module No. 13 Regulation and Management

    E-Print Network [OSTI]

    Lawrence, Rick L.

    Nutrient Management Module No. 13 Manure and Biosolids: Regulation and Management by Clain Jones is the thirteenth in a series of Extension materials designed to provide Extension agents, Certified Crop Advisers (CCAs), consultants, and producers with pertinent information on nutrient management issues. To make

  2. 4-Poster Tick Management and White-tailed Deer Management

    E-Print Network [OSTI]

    Homes, Christopher C.

    the methodologies for Integrated Wildlife Damage Management approach #12;Environmental Assessment Purpose and NeedUpdate on: 4-Poster Tick Management and White-tailed Deer Management Tim Green Environmental been on hold until present #12;Environmental Assessment Current Status: · Adopting two existing EAs - U

  3. Automated Transportation Management System (ATMS) | Department...

    Broader source: Energy.gov (indexed) [DOE]

    of Energy's (DOE's) Automated Transportation Management System is an integrated web-based logistics management system allowing users to manage inbound and outbound freight...

  4. Risk Management Process Overview | Department of Energy

    Office of Environmental Management (EM)

    risk management process The cybersecurity risk management process explained in the Electricity Sector Cybersecurity Risk Management Process (RMP) Guideline has two primary...

  5. Interagency Energy Management Task Force Members

    Broader source: Energy.gov [DOE]

    The Interagency Energy Management Task Force is led by the Federal Energy Management Program director. Members include energy and sustainability managers from federal agencies.

  6. DOE Challenge Home Recommended Quality Management Provisions...

    Broader source: Energy.gov (indexed) [DOE]

    Recommended Quality Management Provisions DOE Challenge Home Recommended Quality Management Provisions DOE Challenge Home Recommended Quality Management Provisions. qm6-14-13.pdf...

  7. California cotton growers utilize integrated pest management

    E-Print Network [OSTI]

    Brodt, Sonja; Goodell, Peter B.; Krebill-Prather, Rose L.; Vargas, Ron N.

    2007-01-01T23:59:59.000Z

    a comprehensive survey of pest management decision-makingfor overall health. Surveys of pest management prac- ticespest management advice was almost universal among the survey

  8. Does Management Matter? Evidence from India

    E-Print Network [OSTI]

    Bloom, Nicholas; Eifert, Benn; Mahajan, Aprajit; McKenzie, David; Roberts, John

    2012-01-01T23:59:59.000Z

    a detailed ground- based management survey of every textileoutput markets. A2) Management survey in 2011 In 2011 weUS Census 2011 Management and Organization Survey http://

  9. Operations and Maintenance Program Management

    Broader source: Energy.gov [DOE]

    Effective management is critical to any operations and maintenance (O&M) program. The management function should bind the distinct parts of the O&M program into a cohesive entity.

  10. Waste Management | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Cleanup Waste Management Waste Management July 15, 2014 Energy Expos Students work in groups to create hands-on exhibits about the energy sources that power the nation, ways to...

  11. Environmental Management (EM) Cleanup Projects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-09-24T23:59:59.000Z

    The guide supports DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, and provides guidance on environmental management cleanup projects. Canceled by DOE N 251.105.

  12. Operations and Maintenance Management Support

    Broader source: Energy.gov [DOE]

    Federal operations and maintenance (O&M) programs must gain full support from management to succeed. Management understanding and buying into the program elevates O&M importance and allows...

  13. ENERGY STAR Portfolio Manager 101

    Office of Energy Efficiency and Renewable Energy (EERE)

    Join us as we introduce and demonstrate the core functionality of EPA’s ENERGY STAR Portfolio Manager tool. Attendees will learn how to: navigate Portfolio Manager; add a property and enter details...

  14. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 2001 prepared by: Data Management Group Joint Program..............................................................................2 Text Based Data Retrieval System `drs' ..........................................................2 Internet Browser Data Retrieval System (iDRS)..............................................3 Complex Data

  15. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 1999 prepared by: Data Management Group Joint Program................................................................. 1 INFORMATION PROCESSING ............................................. 2 Text Based Data Retrieval System `drs' ........................ 2 Internet Browser Data Retrieval System (iDRS) ............ 3

  16. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    iv Data Management Group Annual Report 2003 City of Hamilton City of Toronto GO Transit Regional of York Toronto Transit Commission The Data Management Group is a research program located ........................................................................................................ 3 Text-based Data Retrieval System `drs

  17. Departmental Cyber Security Management Policy

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-05-08T23:59:59.000Z

    The Departmental Cyber Security Management (DCSM) Policy was developed to further clarify and support the elements of the Integrated Safeguards and Security Management (ISSM) Policy regarding cyber security. Certified 9-23-10. No cancellation.

  18. Emergency Animal Management during Disasters

    E-Print Network [OSTI]

    Dement, Angela

    2006-10-23T23:59:59.000Z

    This publication explains how communities and counties can incorporate animal issues into their emergency management plans. It explains what local plans should include, what role county Extension agents can play, and how animal management plans can...

  19. Associate Vice President Facilities Management

    E-Print Network [OSTI]

    Milchberg, Howard

    Operations & Energy Services Jack Baker Executive Director Building & Landscape Maintenance Harry Teabout III Safety HVAC Systems HVAC Systems Administration/ Signs & Graphics Administration/ Signs & Graphics Piped-Campus Facilities Director Department of Engineering & Energy VACANT Energy Management Energy Management Engineering

  20. Solid Waste Management Program (Missouri)

    Broader source: Energy.gov [DOE]

    The Solid Waste Management Program in the Department of Natural Resources regulates the management of solid waste in the state of Missouri. A permit is required prior to the construction or...

  1. Southern Region Watershed Management Project

    E-Print Network [OSTI]

    Coordinators and the organization, management and activities of the Southern Region Water Quality Planning1 Southern Region Watershed Management Project September 15, 2000 to September 14, 2005 Terminal responding to water quality and conservation issues with educational assistance, technology development

  2. ENERGY STAR Portfolio Manager 201

    Office of Energy Efficiency and Renewable Energy (EERE)

    Continue to learn about EPA’s new ENERGY STAR Portfolio Manager tool, with a deeper dive into more advanced functionalities such as: managing and tracking changes to your property uses over time;...

  3. Earned Value Management System (EVMS)

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-05-06T23:59:59.000Z

    The Guide supports the Departments initiatives to improve program, project, and contract management through the implementation and surveillance of contractors earned value management systems. Canceled by DOE G 413.3-10A.

  4. Enforcement Project Management Handbook. Directive

    SciTech Connect (OSTI)

    Not Available

    1991-01-01T23:59:59.000Z

    The handbook has been prepared as a basic reference and training manual to assist RPMs (Remedial Project Managers) and OSCs (On-Scene Coordinators) in planning, negotiating, and managing various enforcement actions.

  5. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30T23:59:59.000Z

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09

  6. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30T23:59:59.000Z

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09.

  7. Where do firms manage earnings?

    E-Print Network [OSTI]

    Dyreng, Scott D.

    Despite decades of research on how, why, and when companies manage earnings, there is a paucity of evidence about the geographic location of earnings management within multinational firms. In this study, we examine where ...

  8. Quality assurance and data management

    SciTech Connect (OSTI)

    Lockrem, L.L.

    1998-01-12T23:59:59.000Z

    This report contains graphs and tables relating to quality assurance and data management for environmental quality at Hanford Reservation.

  9. Information Security Office Risk Management

    E-Print Network [OSTI]

    Alpay, S. Pamir

    or Approved) 6/01/2013 CISO Jason Pufahl, CISO Approved 6/01/2013 RMAC Risk Management Advisory Council

  10. Natural Resource Management Plan Update

    E-Print Network [OSTI]

    Homes, Christopher C.

    wood industry, some farming in area of Solar Farm 3 #12;History of Natural Resource Management Formal

  11. GOVERNING COUNCIL Asbestos Management Policy

    E-Print Network [OSTI]

    Boonstra, Rudy

    : · The University will establish an Asbestos Management Program which will outline a comprehensive system to actively manage and stringently control all asbestos-containing materials in University buildings, and allGOVERNING COUNCIL Asbestos Management Policy June 23, 2011 To request an official copy

  12. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 2000 prepared by: Data Management Group Joint Program the operation of the EMME/2 simu- lation package on the Data Management Group's computer system. During the year computing resource at the DMG. A major challenge in 2000 was to maintain this service while operating out

  13. Work Experience Guidance for Managers

    E-Print Network [OSTI]

    Work Experience Guidance for Managers When approached with a request for work experience, managers. Any queries regarding CRB checks should be directed to your designated HR Manager. When a work any work, paid or unpaid: Before 7am or after 7pm For more than two hours on a school day or Sunday

  14. Flexible Work Arrangements Manager Guidelines

    E-Print Network [OSTI]

    Jones, Michelle

    Flexible Work Arrangements Manager Guidelines The Ohio State University Office of Human Resources Page 1 of 2 Flexible Work Arrangement ­ Manager Assessment Issued 07/15/10 When you receive a proposal your manager to review for a decision. Remember that granting a flexible work arrangement may help

  15. COMPARING FOREST MANAGEMENT PRACTICES UNDER

    E-Print Network [OSTI]

    COMPARING FOREST MANAGEMENT PRACTICES UNDER COMMUNITY-BASED AND CONVENTIONAL TENURES IN BRITISH OF MASTER OF RESOURCE MANAGEMENT In the School of Resource and Environmental Management © David Mealiea 2011 of Canada, this work may be reproduced, without authorization, under the conditions for Fair Dealing

  16. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT AND ENVIRONMENTAL HEALTH & INSTRUCTIONAL SAFETY 2009 ANNUAL REPORTS #12;2009 Annual Report Page 2 RISK MANAGEMENT I. Program Cost One method to assess the effectiveness of the University's risk management program is to compare the annual cost

  17. Algorithmic Aspects of Risk Management

    E-Print Network [OSTI]

    Stehr, Mark-Oliver

    Algorithmic Aspects of Risk Management Ashish Gehani1 , Lee Zaniewski2 , and K. Subramani2 1 SRI International 2 West Virginia University Abstract. Risk analysis has been used to manage the security of sys configuration. This allows risk management to occur in real time and reduces the window of exposure to attack

  18. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT 2003-04 ANNUAL REPORT OFFICE OF UNIVERSITY RISK MANAGEMENT #12;2 I. Introduction "Of course you have to go out on a limb sometimes, that's where the best outcome in a changing environment, is the essence of risk management.3 This Report was developed

  19. Quantitative Risk Management Rudiger Frey

    E-Print Network [OSTI]

    Frey, Rüdiger

    Lecture Quantitative Risk Management R¨udiger Frey Universit¨at Leipzig Wintersemester 2010 risk management C. Introduction to Portfolio Credit Derivatives c 2010 (Frey) 1 #12;A. Introduction of counterparties. Measuring and management of credit risk is of high importance for financial institutions

  20. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT 2010 ANNUAL REPORT #12;2010 Annual Report Page 2 I. Program Cost One method to assess the effectiveness of the University's risk management,538 $ 197,196 TOTAL Risk Management Costs $ 4,675,390 $ 4,541,975 $ 3,764,749 $ 3,703,959 $ 4

  1. Professional Certificate in Risk Management

    E-Print Network [OSTI]

    Carleton University

    Professional Certificate in Risk Management 2010 Program 3 Part-time Courses CRM01: Essentials of Risk Management ­ Next Session Fall 2010 CRM02: Risk Control ­ Jan. 12 - April 26, 2010 CRM03: Risk to apply for the Canadian Risk Management (CRM) designation. #12;Professional Certificate in Risk

  2. Regional Summary Pacific Management Context

    E-Print Network [OSTI]

    . Bocaccio, Pacific ocean perch, cowcod, and darkblotched and widow rockfish are currently in rebuildingRegional Summary Pacific Management Context The Pacific Region includes California, Oregon, and Washington. Federal fisheries in this region are managed by the Pacific Fishery Management Council (PFMC

  3. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 2004 City of Hamilton City of Toronto GO Transit Regional of York Toronto Transit Commission The Data Management Group is a research program located of the funding partners: Ministry of Transportation, Ontario #12;SUMMARY The Data Management Group (DMG

  4. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 1997 #12;Data Management Group Annual Report 1997 A co-operative project that is jointly funded by members of the Toronto Area Transportation Planning Data Collection: (416) 978-3941 #12;Data Management Group 1997 Annual Report Table of Contents 1 INTRODUCTION

  5. Managing and Archiving Research Documents

    E-Print Network [OSTI]

    Johannesson, Henrik

    Managing and Archiving Research Documents Summary of "Hantering och arkivering av Documents ­ A Handbook for the Research Activity at the University of Gothenburg) #12;Managing and Archiving a method to manage and archive research documents1 . A project group of approximately 20 researchers formed

  6. Computerized dairy records management systems

    E-Print Network [OSTI]

    Acosta, Alejandro E. Gonzalez

    1992-01-01T23:59:59.000Z

    . . . . . . 1. 3. Management Tools. . . . . . . . . . . . . . . . . . . . . . 1. 3. 1. Record Keeping History. . . . . . . . . . . . . . . . . . . . . . . . . . . 3 . . . . . . . 3 . . . . . 3 . . . . . . . 4 4 . . . . . . . 5 1. 3. 2. Hand-Kept v. s.... Computerized Records. . . . . . . . . . . 6 1. 3. 3. Direct Access to Records by Telephone. . . . . . . . . 6 II. HEIFER MANAGEMENT. 2. 1. Dairy Replacements. . 2. 2. Heifers Breeding Management . . . . . . . . . . . 7 . . . . . . . 7 . . . . . . . 8...

  7. Hierarchical Adaptive Dynamic Power Management

    E-Print Network [OSTI]

    Chen, Yuanzhu Peter

    Hierarchical Adaptive Dynamic Power Management Zhiyuan Ren, Member, IEEE, Bruce H. Krogh, Fellow, IEEE, and Radu Marculescu, Member, IEEE Abstract--Dynamic power management aims at extending battery management strategies can lead to poor performance or unnecessary power consumption when there are wide

  8. QUALITY MANAGEMENT AGENDA General Agenda

    E-Print Network [OSTI]

    1 QUALITY MANAGEMENT AGENDA General Agenda A week before study commences, the following matters a meeting for the following purposes: 1. Read the report that is related to quality management for the previous term. 2. Conduct a general review of the procedures of quality management and reinforcement

  9. Decision Support and Risk Management

    E-Print Network [OSTI]

    and emergency management officials during the planning, incident management preparedness, and response phasesDecision Support and Risk Management CVMDM: Community Vaccination and Mass Dispensing Model What and the performance of prophylaxis supply logistics and PODs. Decision and Information Sciences Division Decision

  10. Energy Management and Conservation Plan

    E-Print Network [OSTI]

    Energy Management and Conservation Plan December 2005 #12;Texas Transportation Institute December 2005 Energy Management and Conservation Plan Page 2 of 24 Table of Contents Section One: Executive: Reporting Progress #12;Texas Transportation Institute December 2005 Energy Management and Conservation Plan

  11. ENERGY MANAGEMENT OPERATIONAL PROCEDURE MANUAL

    E-Print Network [OSTI]

    Harman, Neal.A.

    ENERGY MANAGEMENT OPERATIONAL PROCEDURE MANUAL Swansea University Estates Services Singleton Park Swansea SA2 8PP Tel 01792 295819 Fax 01792 295820 #12;Swansea University Energy Management Operational ......................................................................................11 #12;Swansea University Energy Management Operational Procedural Manual Estates Services April 2008

  12. Implementing Nutrient Management Practices in

    E-Print Network [OSTI]

    Balser, Teri C.

    /Implementation Efforts Nutrient and Pest Management Program (NPM) Certified Crop Adviser (CCA) Training Local Nutrient Assurance Team #12;Nutrient & Pest Management (NPM) Program What we do · Promote agricultural management conservation staff. · Over 400 participants to date Presented by: UWEX, NPM, DATCP, NRCS Financial support

  13. MANAGEMENT CONTROL SYSTEM IN PUBLIC

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    essential aspect of the public management device: compliance with legal rules. Gradually, a new objective of the budgetary system. Thus, public organizations need to create new tools to manage their activities or use, despite the number of reforms adopted in the name of New Public Management, numerous authors also noted

  14. Student Employment Record Management Guide

    E-Print Network [OSTI]

    Alpay, S. Pamir

    Student Employment Record Management Guide Need more space? The answer could be easier than you these records management standards is not always an intuitive task. Please take advantage of your resources and we will help you to make sure records management turns into something that runs in the background

  15. Vehicle Management Driver Safety Program

    E-Print Network [OSTI]

    Machel, Hans

    Vehicle Management and Driver Safety Program Manual Facilities & Operations / Finance & Administration Version 2 April 2012 #12;© 2012 University of Alberta. #12;The Vehicle Management and Driver of employment. Driver Acknowledgement I have received the University of Alberta, Vehicle Management and Driver

  16. A 17025:2005A 17025:2005 Management SystemManagement System

    E-Print Network [OSTI]

    A 17025:2005A 17025:2005 Management SystemManagement System Made SimpleMade Simple What to think about when reviewingWhat to think about when reviewing the Management Systemthe Management System #12 role does top management play?le does top management play? Technical Manager/Quality Manager

  17. Environmental Management System Plan

    SciTech Connect (OSTI)

    Fox, Robert; Thorson, Patrick; Horst, Blair; Speros, John; Rothermich, Nancy; Hatayama, Howard

    2009-03-24T23:59:59.000Z

    Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management establishes the policy that Federal agencies conduct their environmental, transportation, and energy-related activities in a manner that is environmentally, economically and fiscally sound, integrated, continually improving, efficient, and sustainable. The Department of Energy (DOE) has approved DOE Order 450.1A, Environmental Protection Program and DOE Order 430.2B, Departmental Energy, Renewable Energy and Transportation Management as the means of achieving the provisions of this Executive Order. DOE Order 450.1A mandates the development of Environmental Management Systems (EMS) to implement sustainable environmental stewardship practices that: (1) Protect the air, water, land, and other natural and cultural resources potentially impacted by facility operations; (2) Meet or exceed applicable environmental, public health, and resource protection laws and regulations; and (3) Implement cost-effective business practices. In addition, the DOE Order 450.1A mandates that the EMS must be integrated with a facility's Integrated Safety Management System (ISMS) established pursuant to DOE P 450.4, 'Safety Management System Policy'. DOE Order 430.2B mandates an energy management program that considers energy use and renewable energy, water, new and renovated buildings, and vehicle fleet activities. The Order incorporates the provisions of the Energy Policy Act of 2005 and Energy Independence and Security Act of 2007. The Order also includes the DOE's Transformational Energy Action Management initiative, which assures compliance is achieved through an Executable Plan that is prepared and updated annually by Lawrence Berkeley National Laboratory (LBNL, Berkeley Lab, or the Laboratory) and then approved by the DOE Berkeley Site Office. At the time of this revision to the EMS plan, the 'FY2009 LBNL Sustainability Executable Plan' represented the most current Executable Plan. These DOE Orders and associated policies establish goals and sustainable stewardship practices that are protective of environmental, natural, and cultural resources, and take a life cycle approach that considers aspects such as: (1) Acquisition and use of environmentally preferable products; (2) Electronics stewardship; (3) Energy conservation, energy efficiency, and renewable energy; (4) Pollution prevention, with emphasis on toxic and hazardous chemical and material reduction; (5) Procurement of efficient energy and water consuming materials and equipment; (6) Recycling and reuse; (7) Sustainable and high-performance building design; (8) Transportation and fleet management; and (9) Water conservation. LBNL's approach to sustainable environmental stewardship required under Order 450.1A poses the challenge of implementing its EMS in a compliance-based, performance-based, and cost-effective manner. In other words, the EMS must deliver real and tangible business value at a minimal cost. The purpose of this plan is to describe Berkeley Lab's approach for achieving such an EMS, including an overview of the roles and responsibilities of key Laboratory parties. This approach begins with a broad-based environmental policy consistent with that stated in Chapter 11 of the LBNL Health and Safety Manual (PUB-3000). This policy states that Berkeley Lab is committed to the following: (1) Complying with applicable environmental, public health, and resource conservation laws and regulations. (2) Preventing pollution, minimizing waste, and conserving natural resources. (3) Correcting environmental hazards and cleaning up existing environmental problems, and (4) Continually improving the Laboratory's environmental performance while maintaining operational capability and sustaining the overall mission of the Laboratory. A continual cycle of planning, implementing, evaluating, and improving processes will be performed to achieve goals, objectives, and targets that will help LBNL carry out this policy. Each year, environmental aspects will be identified and their impacts to the environm

  18. Evaluating next-generation environmental policy tools : adaptive management in the Bureau of Land Management

    E-Print Network [OSTI]

    Brandenburg, Peter (Peter J.)

    2005-01-01T23:59:59.000Z

    The U.S. Bureau of Land Management (BLM) has begun to embrace the concept adaptive management as an alternative to traditional natural resource planning and management models. Adaptive management may provide BLM managers ...

  19. Best Management Practices for Aquatic Vegetation Management Principal Investigator: Joseph E. Morris

    E-Print Network [OSTI]

    Koford, Rolf R.

    . Develop educational materials related to aquatic plant identification and their specific managementBest Management Practices for Aquatic Vegetation Management Principal Investigator: Joseph E vegetation management with the ultimate goal of producing the best management practices protocol in Iowa

  20. Power System load management

    SciTech Connect (OSTI)

    Rudenko, Yu.N.; Semenov, V.A.; Sovalov, S.A.; Syutkin, B.D.

    1984-01-01T23:59:59.000Z

    The variation in demand nonuniformity is analyzed for the Unified Electric Power System of the USSR and certain interconnected power systems; the conditions for handling such nonuniformity with utilization of generating equipment having differing flexibility capabilities are also considered. On this basis approaches and techniques for acting on user loads, load management, in order to assure a balance between generated and consumed power are considered.

  1. Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1995-09-25T23:59:59.000Z

    The order establishes policy, and assigns and describes roles and responsibilities for the DOE Emergency Management System. DOE 5500.1B Chg 1; DOE 5500.2B Chg 1; DOE 5500.3A Chg 1; DOE 5500.4A; DOE 5500.5A; DOE 5500.7B; DOE 5500.8A; DOE 5500.9A, and DOE 5500.10A Chg 1. Canceled by DOE O 151.1A.

  2. Comprehensive Irrigation Management

    E-Print Network [OSTI]

    Cook, K.

    2011-01-01T23:59:59.000Z

    The other irrigation ? Optimizing water consumption in urban landscapes Kenneth Cook President, Intelligent Irrigation Banyan Water Water risk ? increasing rapidly in the US 2 Sustainable property management 3 ? ?Green? ? Audubon Cert..., COO ? Improve efficiencies and use in urban landscapes ? Make efficiency changes in the landscape early on ? too important for all stakeholders to get to point of no water availability for irrigation ? Real estate values affected by as much...

  3. Caged Layer Management.

    E-Print Network [OSTI]

    Cawley, W. O.; Quisenberry, J. H.; Allen, W. S.

    1966-01-01T23:59:59.000Z

    so flies and odors will not annoy them. 5. Allow adjacent acreage for future expansion. Kind of Bird In egg production, the most important capital investment is the bird. For maximum return, she must meet exacting specifications. The most im.... But without ra si: ~perlative management and careful attention to etails, these lowered costs will be more than offset y increased mortality, reduced production, more irty and broken eggs and a greater fly problem. .esearch at Texas A&M University has...

  4. Conditional data watchpoint management

    DOE Patents [OSTI]

    Burdick, Dean Joseph (Austin, TX); Vaidyanathan, Basu (Austin, TX)

    2010-08-24T23:59:59.000Z

    A method, system and computer program product for managing a conditional data watchpoint in a set of instructions being traced is shown in accordance with illustrative embodiments. In one particular embodiment, the method comprises initializing a conditional data watchpoint and determining the watchpoint has been encountered. Upon that determination, examining a current instruction context associated with the encountered watchpoint prior to completion of the current instruction execution, further determining a first action responsive to a positive context examination; otherwise, determining a second action.

  5. Operations Task Management (OTM)

    SciTech Connect (OSTI)

    Miller, C.B.; Duck, C.H.

    1985-10-01T23:59:59.000Z

    This paper reviews the steps taken by management at Ashland Oil to reduce expenses, including an analysis of every aspect of the refinery. It was determined that the areas most adaptable to improvement were the maintenance department, storerooms, the laboratory and energy utilization. The authors focus, however, on the difficulties met in implementing an effective cost control program in the operations area, detailing the reasons why and examining the system ultimately installed in this area.

  6. Steam System Data Management

    E-Print Network [OSTI]

    Roberts, D.

    2013-01-01T23:59:59.000Z

    Steam System Data Management What Does It Include Safety In Motion Wal?Tech?Valve,?Inc. 251?438?2203 The Real Genius Behind Technology Is People ESL-IE-13-05-35 Proceedings of the Thrity-Fifth Industrial Energy Technology Conference New... ? Fabrication Training (Six Year Training) ? Welding Certifications ?Retired From Chevron After 25 Years ? Established A Steam System Program ? Planner For Routine Maintenance Work ? Planner For Steam System Improvements ? Wal-Tech Valve, Inc. ? Purchased...

  7. Conservation and drought management

    E-Print Network [OSTI]

    Finch, Calvin

    2012-01-01T23:59:59.000Z

    conservation technologies are high e#19;ciency toilets, showerheads, washing machines and water heaters. Behavioral changes include turning the water o#27; except when rinsing while shaving and brushing teeth and pu#26;ing full loads in dishwashers...Fall 2012 tx H2O 5 Column by Dr. Calvin Finch, Water Conservation and Technology Center director Conservation and Drought Management WAT E R CONSERVATION & TECHNOLOGY CENTER Securing Our Water Future Water conservation and drought...

  8. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-{kappa}B translocation

    SciTech Connect (OSTI)

    Jawan, Bruno [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Kao, Y.-H. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Goto, Shigeru [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Surgery, Iwao Hospital, 3059-1 Kawakami, Yufuin, Oita 879-5102 (Japan); Pan, M.-C. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Lin, Y.-C.; Hsu, L.-W.; Nakano, Toshiaki; Lai, C.-Y.; Sun, C.-K.; Cheng, Y.-F. [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Tai, M.-H. [Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Department of Medical Research and Education, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan (China)] (and others)

    2008-06-15T23:59:59.000Z

    Propofol (PPF), a widely used intravenous anesthetic for induction and maintenance of anesthesia during surgeries, was found to possess suppressive effect on host immunity. This study aimed at investigating whether PPF plays a modulatory role in the lipopolysaccharide (LPS)-induced inflammatory cytokine expression in a cell line of rat hepatocytes. Morphological observation and viability assay showed that PPF exhibits no cytotoxicity at concentrations up to 300 {mu}M after 48 h incubation. Pretreatment with 100 {mu}M PPF for 24 h prior to LPS stimulation was performed to investigate the modulatory effect on LPS-induced inflammatory gene production. The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-{alpha}, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression. Western blotting analysis showed that PPF pretreatment potentiated the LPS-induced TLR-4 downregulation. Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes. In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and I{kappa}B{alpha}, as well as the nuclear translocation of NF-{kappa}B primed by LPS. Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-{kappa}B nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway. In conclusion, PPF as an anesthetic may clinically benefit those patients who are vulnerable to sepsis by alleviating sepsis-related inflammatory response in livers.

  9. D-Saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-?B and PKC signaling

    SciTech Connect (OSTI)

    Bhattacharya, Semantee [Department of Life Sciences and Biotechnology, Jadavpur University, 188, Raja S C Mullick Road, Kolkata 700 032 (India); Manna, Prasenjit [Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700054 (India); Gachhui, Ratan [Department of Life Sciences and Biotechnology, Jadavpur University, 188, Raja S C Mullick Road, Kolkata 700 032 (India); Sil, Parames C., E-mail: parames@bosemain.boseinst.ac.in [Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700054 (India)

    2013-02-15T23:59:59.000Z

    Increasing evidence suggests that oxidative stress is involved in the pathogenesis of diabetic nephropathy (DN) and this can be attenuated by antioxidants. D-Saccharic acid 1,4-lactone (DSL) is known for its detoxifying and antioxidant properties. Our early investigation showed that DSL can ameliorate alloxan (ALX) induced diabetes mellitus and oxidative stress in rats by inhibiting pancreatic ?-cell apoptosis. In the present study we, therefore, investigated the protective role of DSL against renal injury in ALX induced diabetic rats. ALX exposure (at a dose of 120 mg/kg body weight, i. p., once) elevated the blood glucose level, serum markers related to renal injury, the production of reactive oxygen species (ROS), and disturbed the intra-cellular antioxidant machineries. Oral administration of DSL (80 mg/kg body weight) restored all these alterations close to normal. In addition, DSL could also normalize the aldose reductase activity which was found to increase in the diabetic rats. Investigating the mechanism of its protective activity, we observed the activation of different isoforms of PKC along with the accumulation of matrix proteins like collagen and fibronectin. The diabetic rats also showed nuclear translocation of NF-?B and increase in the concentration of inflammatory cytokines in the renal tissue. The activation of mitochondria dependent apoptotic pathway was observed in the diabetic rat kidneys. However, treatment of diabetic rats with DSL counteracted all these changes. These findings, for the first time, demonstrated that DSL could ameliorate renal dysfunction in diabetic rats by suppressing the oxidative stress related signalling pathways. - Highlights: ? Sustained hyperglycemia and oxidative stress lead to diabetic renal injury. ? D-saccharic acid 1,4-lactone prevents renal damage in alloxan-induced diabetes. ? It restores intra-cellular antioxidant machineries and kidney apoptosis. ? DSL reduces hyperglycemia-mediated oxidative stress via NF-kB and PKC signaling. ? DSL may act as a beneficial agent in hyperglycemia induced renal disorder.

  10. Employee Motivation in Energy Management Programs

    E-Print Network [OSTI]

    Hogeland, A. W.

    1982-01-01T23:59:59.000Z

    Effective management of energy requires the same degree of manager/employee motivation as other management responsibilities. Basically the same factors cause managers and employees to be motivated and effective. In this discussion, we will review...

  11. Department of Environmental Health & Safety Emergency Management

    E-Print Network [OSTI]

    O'Toole, Alice J.

    Management Fire & Life Safety Industrial Hygiene Laboratory Safety Occupational & General Safety Management Environmental Management Fire & Life Safety Industrial Hygiene Laboratory Safety Occupational Values A Note from the Director Environmental Management Fire & Life Safety Lab Safety & Industrial

  12. AVLIS production plant waste management plan

    SciTech Connect (OSTI)

    Not Available

    1984-11-15T23:59:59.000Z

    Following the executive summary, this document contains the following: (1) waste management facilities design objectives; (2) AVLIS production plant wastes; (3) waste management design criteria; (4) waste management plan description; and (5) waste management plan implementation. 17 figures, 18 tables.

  13. Life Cycle Asset Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1998-10-14T23:59:59.000Z

    (The following directives are deleted or consolidated into this Order and shall be phased out as noted in Paragraph 2: DOE 1332.1A; DOE 4010.1A; DOE 4300.1C; DOE 4320.1B; DOE 4320.2A; DOE 4330.4B; DOE 4330.5; DOE 4540.1C; DOE 4700.1). This Order supersedes specific project management provisions within DOE O 430.1A, LIFE CYCLE ASSET MANAGEMENT. The specific paragraphs canceled by this Order are 6e(7); 7a(3); 7b(11) and (14); 7c(4),(6),(7),(11), and (16); 7d(4) and (8); 7e(3),(10), and (17); Attachment 1, Definitions (item 30 - Line Item Project, item 42 - Project, item 48 - Strategic System); and Attachment 2, Contractor Requirements Document (paragraph 1d regarding a project management system). The remainder of DOE O 430.1A remains in effect. Cancels DOE O 430.1. Canceled by DOE O 413.3.

  14. LEGACY MANAGEMENT REQUIRES INFORMATION

    SciTech Connect (OSTI)

    CONNELL, C.W.; HILDEBRAND, R.D.

    2006-12-14T23:59:59.000Z

    ''Legacy Management Requires Information'' describes the goal(s) of the US Department of Energy's Office of Legacy Management (LM) relative to maintaining critical records and the way those goals are being addressed at Hanford. The paper discusses the current practices for document control, as well as the use of modern databases for both storing and accessing the data to support cleanup decisions. In addition to the information goals of LM, the Hanford Federal Facility Agreement and Consent Order, known as the ''Tri-Party Agreement'' (TPA) is one of the main drivers in documentation and data management. The TPA, which specifies discrete milestones for cleaning up the Hanford Site, is a legally binding agreement among the US Department of Energy (DOE), the Washington State Department of Ecology (Ecology), and the US Environmental Protection Agency (EPA). The TPA requires that DOE provide the lead regulatory agency with the results of analytical laboratory and non-laboratory tests/readings to help guide them in making decisions. The Agreement also calls for each signatory to preserve--for at least ten years after the Agreement has ended--all of the records in its or its contractors, possession related to sampling, analysis, investigations, and monitoring conducted. The tools used at Hanford to meet TPA requirements are also the tools that can satisfy the needs of LM.

  15. Environmental management activities

    SciTech Connect (OSTI)

    NONE

    1997-07-01T23:59:59.000Z

    The Office of Environmental Management (EM) has been delegated the responsibility for the Department of Energy`s (DOE`s) cleanup of the nuclear weapons complex. The nature and magnitude of the waste management and environmental remediation problem requires the identification of technologies and scientific expertise from domestic and foreign sources. Within the United States, operational DOE facilities, as well as the decontamination and decommissioning of inactive facilities, have produced significant amounts of radioactive, hazardous, and mixed wastes. In order to ensure worker safety and the protection of the public, DOE must: (1) assess, remediate, and monitor sites and facilities; (2) store, treat, and dispose of wastes from past and current operations; and (3) develop and implement innovative technologies for environmental restoration and waste management. The EM directive necessitates looking beyond domestic capabilities to technological solutions found outside US borders. Following the collapse of the Soviet regime, formerly restricted elite Soviet scientific expertise became available to the West. EM has established a cooperative technology development program with Russian scientific institutes that meets domestic cleanup objectives by: (1) identifying and accessing Russian EM-related technologies, thereby leveraging investments and providing cost-savings; (2) improving access to technical information, scientific expertise, and technologies applicable to EM needs; and (3) increasing US private sector opportunities in Russian in EM-related areas.

  16. Risk Management in Biopharmaceutical Supply Chains

    E-Print Network [OSTI]

    Ma, Yao

    2011-01-01T23:59:59.000Z

    Supply Chain Risk Managementof Recent Work on Supply Chain Risk Management . . . . .M. , Supply chain risk management: Outlining an agenda for

  17. Business Opportunities Session Office of Environmental Management...

    Broader source: Energy.gov (indexed) [DOE]

    Business Opportunities Session Office of Environmental Management Business Opportunities Session Office of Environmental Management Environmental Clean up Business Opportunities...

  18. Fernald Environmental Management Project Archived Soil & Groundwater...

    Office of Environmental Management (EM)

    Fernald Environmental Management Project Archived Soil & Groundwater Master Reports Fernald Environmental Management Project Archived Soil & Groundwater Master Reports Fernald...

  19. Miamisburg Environmental Management Project Archived Soil & Groundwate...

    Office of Environmental Management (EM)

    Miamisburg Environmental Management Project Archived Soil & Groundwater Master Reports Miamisburg Environmental Management Project Archived Soil & Groundwater Master Reports...

  20. Independent Oversight Focused Safety Management Evaluation, Idaho...

    Office of Environmental Management (EM)

    Focused Safety Management Evaluation, Idaho National Engineering and Environmental Laboratory - January 2001 Independent Oversight Focused Safety Management Evaluation, Idaho...

  1. The Value of Information in Inventory Management

    E-Print Network [OSTI]

    2007-05-24T23:59:59.000Z

    Inventory management traditionally assumes the precise knowledge of the ... stage inventory management in a robust optimization framework; the precise ...

  2. Electronic Records Management Software Applications Design Criteria...

    Energy Savers [EERE]

    Electronic Records Management Software Applications Design Criteria Standard Electronic Records Management Software Applications Design Criteria Standard This Standard is reissued...

  3. CONTACTS FOR INFORMATION MANAGEMENT: Forms, Information Collection...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CONTACTS FOR INFORMATION MANAGEMENT: Forms, Information Collection, Privacy & Records CONTACTS FOR INFORMATION MANAGEMENT: Forms, Information Collection, Privacy & Records Troy...

  4. Training for Records and Information Management

    Broader source: Energy.gov [DOE]

    Records Management Training:  NARA Records Management Training   NARA Targeted Assistance NARA Brochures Training Presentation:  Information Collection Requests/PRA (pdf)  

  5. Better Buildings Neighborhood Program Grant Recipient Management...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Better Buildings Neighborhood Program Grant Recipient Management Handbook Better Buildings Neighborhood Program Grant Recipient Management Handbook Better Buildings Neighborhood...

  6. Building International Emergency Management Systems | National...

    National Nuclear Security Administration (NNSA)

    Building International Emergency Management Systems | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing...

  7. GARS ESH Management Review GARS Research Operations

    E-Print Network [OSTI]

    Ohta, Shigemi

    Assessment March 2013 No Findings Records Management April 2013 Lab Level OFI ­ identification & inventoryGARS ESH Management Review GARS Research Operations December 11, 2013 #12;GARS FY13 ESH Management Review ­ Slide 2 Management Review Scope Senior Management shall review the EMS and OSH Management

  8. Arteriovenous Malformation Management

    SciTech Connect (OSTI)

    Yakes, Wayne F. [Interventional Radiology and Interventional Neuroradiology, Radiology Imaging Associates, P.C., Colorado NeurologicalInstitute, Swedish Medical Center, 501 E. Hampden Avenue, Englewood, CO 80110 (United States); Rossi, Plinio [Department of Radiology, Universita Degli Studi Di Roma, 'La Sapienza', 00161 Rome (Italy); Odink, Henk [Department of Radiology, De Wever Hospital, Henri Dunanstrat 5, 6419 PC Heerlen (Netherlands)

    1996-11-15T23:59:59.000Z

    Arteriovenous malformations (AVM) are rare vascular lesions that can present with a myriad of clinical presentations. In our institutions, initial workup consists of a clinical exam, color Doppler imaging, and magnetic resonance imaging. After the initial noninvasive workup, arteriography, at times closed system venography, and ethanol endovascular repair of the AVM is performed under general anesthesia. Depending on the size of the lesion, additional Swan-Ganz line and arterial line monitoring are performed. Patients are usually observed overnight and uneventfully discharged the following day if no complication occurs. Patients are followed at periodic intervals despite cure of their lesion. Long-term follow-up is essential in AVM management.

  9. Depleted uranium management alternatives

    SciTech Connect (OSTI)

    Hertzler, T.J.; Nishimoto, D.D.

    1994-08-01T23:59:59.000Z

    This report evaluates two management alternatives for Department of Energy depleted uranium: continued storage as uranium hexafluoride, and conversion to uranium metal and fabrication to shielding for spent nuclear fuel containers. The results will be used to compare the costs with other alternatives, such as disposal. Cost estimates for the continued storage alternative are based on a life-cycle of 27 years through the year 2020. Cost estimates for the recycle alternative are based on existing conversion process costs and Capital costs for fabricating the containers. Additionally, the recycle alternative accounts for costs associated with intermediate product resale and secondary waste disposal for materials generated during the conversion process.

  10. Real Property Asset Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-09-24T23:59:59.000Z

    The directive establishes an integrated corporate-level, performance based approach to the life-cycle management of our real property assets. It links real property asset planning, programming, budgeting and evaluation to the Department's multi-faceted missions. Successful implementation of this order will enable the Department to carry out our stewardship responsibilities, and will ensure that our facilities and infrastructure are properly sized and in a condition to meet our mission requirements today and in the future. Chg 1, dated 2-8-08. Chg 2, dated 4-25-11

  11. Real Property Asset Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-09-24T23:59:59.000Z

    The directive establishes an integrated corporate-level, performance based approach to the life-cycle management of our real property assets. It links real property asset planning, programming, budgeting and evaluation to the Department's multi-faceted missions. Successful implementation of this order will enable the Department to carry out our stewardship responsibilities, and will ensure that our facilities and infrastructure are properly sized and in a condition to meet our mission requirements today and in the future. Cancels: DOE O 430.1A. Chg 1, dated 2-8-08. Chg 2, dated 4-25-11

  12. Information Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30T23:59:59.000Z

    Provides a framework for managing information, information resources, and information technology investment, which supports the operating elements of the Department in the accomplishment of its missions and functions in both an efficient and effective manner and in accordance with Departmental policy. Cancels: DOE 1324.5B, DOE 5900.1A, DOE 1130.8A, DOE 1330.1D, DOE 1410.2, DOE 1450.3A, DOE 1700.1, DOE 1800.1A, DOE 5300.1C

  13. Power management system

    DOE Patents [OSTI]

    Algrain, Marcelo C. (Peoria, IL); Johnson, Kris W. (Washington, IL); Akasam, Sivaprasad (Peoria, IL); Hoff, Brian D. (East Peoria, IL)

    2007-10-02T23:59:59.000Z

    A method of managing power resources for an electrical system of a vehicle may include identifying enabled power sources from among a plurality of power sources in electrical communication with the electrical system and calculating a threshold power value for the enabled power sources. A total power load placed on the electrical system by one or more power consumers may be measured. If the total power load exceeds the threshold power value, then a determination may be made as to whether one or more additional power sources is available from among the plurality of power sources. At least one of the one or more additional power sources may be enabled, if available.

  14. Environmental management system.

    SciTech Connect (OSTI)

    Salinas, Stephanie A.

    2010-08-01T23:59:59.000Z

    The purpose of the Sandia National Laboratories/New Mexico (SNL/NM) Environmental Management System (EMS) is identification of environmental consequences from SNL/NM activities, products, and/or services to develop objectives and measurable targets for mitigation of any potential impacts to the environment. This Source Document discusses the annual EMS process for analysis of environmental aspects and impacts and also provides the fiscal year (FY) 2010 analysis. Further information on the EMS structure, processes, and procedures are described within the programmatic EMS Manual (PG470222).

  15. Responsive classroom management 

    E-Print Network [OSTI]

    Stough, Laura

    2008-01-01T23:59:59.000Z

    , plus Arlcne. 5- rng, three 1!'nies a clay, and occa;iona! nighttime Thorazine, v;as not at all effective, Navane (thiothixene hydroch!oricle) is a psychotropic agent of the thioxanther;e series which is el'fective in the management of man festarions... for the incr ugement of 1iie manifestatiors ot psychotic disci der' (Pl?sician' Desi& F(efr rence, )976). There was soi, question as to whether she was c tuolly takiiig the rnedicntions. A month prior to her tou~th hospitali-. ation, she become very delusior...

  16. Office of Personnel Management

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2:Introduction toManagementOPAM PolicyOf EnvironmentalGuide, July 29,Office0 -

  17. Plutonium Vulnerability Management Plan

    SciTech Connect (OSTI)

    NONE

    1995-03-01T23:59:59.000Z

    This Plutonium Vulnerability Management Plan describes the Department of Energy`s response to the vulnerabilities identified in the Plutonium Working Group Report which are a result of the cessation of nuclear weapons production. The responses contained in this document are only part of an overall, coordinated approach designed to enable the Department to accelerate conversion of all nuclear materials, including plutonium, to forms suitable for safe, interim storage. The overall actions being taken are discussed in detail in the Department`s Implementation Plan in response to the Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1. This is included as Attachment B.

  18. Risk Management RM

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSAR -DepartmentRetail DemandEnergyRisk Management Review

  19. Integrated Safety Management Policy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613 122Commercial602 1,39732on ArmedManufacturing | DepartmentINTEGRATED SAFETY MANAGEMENT

  20. Land Management - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your Home asLCLSLaboratoryRowland to receiveLand Management About

  1. Asset Management Strategies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041cloth DocumentationProductsAlternativeOperational Management »EnergyHubs |B -

  2. ORISE: Peer Review Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated CodesTransparencyDOENurse Triage Lines Support ORISEMaking aManagement Man

  3. Managing Increased Charging Demand

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment ofLetterEconomyDr.Energy University Managing Increased Charging

  4. EFRC Management Reference Document

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisitingContract ManagementDiscovering HowAnaDynamic SwitchingE xProcess |EEOEFRC EFRC

  5. Project management plan for Contract Management Information System (CONTRACT)

    SciTech Connect (OSTI)

    Severud, K.J.

    1995-01-27T23:59:59.000Z

    The office of the Vice President of A/E Construction for ICF Kaiser has requested that OSHA compliance statistics be made available to management for companies subcontracting to the ICF Kaiser Company. In addition, a need to better manage contract administrative data for the Contracts Administration and the Construction Management Projects organizations has been identified. The Contract Management Information System is being developed to achieve these objectives. This document provides a Project Management Plan for development of the Contract Management Administration System (CONTRACT) by Design Services DAD/CAE Support. The Project Management Plan describes the project work breakdown structure, safety and quality considerations, with associated cost, schedule and project management information. The CONTRACT System is intended to aid the ICF Kaiser divisions with tracking of A/E subcontractor information to include general contract administration information used by the Contracts Administration organization, contract and safety performance data used by the Construction Management Projects and office of the organization and Vice President of A/E Construction.

  6. Robust Investment Management with Uncertainty in Fund Managers ...

    E-Print Network [OSTI]

    2014-12-12T23:59:59.000Z

    set of fund managers, whose asset class allocations are not precisely known to the ... Institutional investors, such as pension funds, university endowments and ...

  7. FLUOR HANFORD SAFETY MANAGEMENT PROGRAMS

    SciTech Connect (OSTI)

    GARVIN, L J; JENSEN, M A

    2004-04-13T23:59:59.000Z

    This document summarizes safety management programs used within the scope of the ''Project Hanford Management Contract''. The document has been developed to meet the format and content requirements of DOE-STD-3009-94, ''Preparation Guide for US. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses''. This document provides summary descriptions of Fluor Hanford safety management programs, which Fluor Hanford nuclear facilities may reference and incorporate into their safety basis when producing facility- or activity-specific documented safety analyses (DSA). Facility- or activity-specific DSAs will identify any variances to the safety management programs described in this document and any specific attributes of these safety management programs that are important for controlling potentially hazardous conditions. In addition, facility- or activity-specific DSAs may identify unique additions to the safety management programs that are needed to control potentially hazardous conditions.

  8. Training Management Information System

    SciTech Connect (OSTI)

    Rackley, M.P.

    1989-01-01T23:59:59.000Z

    The Training Management Information System (TMIS) is an integrated information system for all training related activities. TMIS is at the leading edge of training information systems used in the nuclear industry. The database contains all the necessary records to confirm the department's adherence to accreditation criteria and houses all test questions, student records and information needed to evaluate the training process. The key to the TMIS system is that the impact of any change (i.e., procedure change, new equipment, safety incident in the commercial nuclear industry, etc.) can be tracked throughout the training process. This ensures the best training can be performed that meets the needs of the employees. TMIS is comprised of six functional areas: Job and Task Analysis, Training Materials Design and Development, Exam Management, Student Records/Scheduling, Evaluation, and Commitment Tracking. The system consists of a VAX 6320 Cluster with IBM and MacIntosh computers tied into an ethernet with the VAX. Other peripherals are also tied into the system: Exam Generation Stations to include mark sense readers for test grading, Production PC's for Desk-Top Publishing of Training Material, and PC Image Workstations. 5 figs.

  9. ISSUES MANAGEMENT PROGRAM MANUAL

    SciTech Connect (OSTI)

    Gravois, Melanie

    2007-06-27T23:59:59.000Z

    The Lawrence Berkeley National Laboratory (LBNL) Issues Management Program encompasses the continuous monitoring of work programs, performance and safety to promptly identify issues to determine their risk and significance, their causes, and to identify and effectively implement corrective actions to ensure successful resolution and prevent the same or similar problems from occurring. This document describes the LBNL Issues Management Program and prescribes the process for issues identification, tracking, resolution, closure, validation, and effectiveness of corrective actions. Issues that are governed by this program include program and performance deficiencies or nonconformances that may be identified through employee discovery, internal or external oversight assessment findings, suggested process improvements and associated actions that require formal corrective action. Issues may also be identified in and/or may result in Root Cause Analysis (RCA) reports, Price Anderson Amendment Act (PAAA) reports, Occurrence Reporting and Processing System (ORPS) reports, Accident Investigation reports, assessment reports, and External Oversight reports. The scope of these issues may include issues of both high and low significance as well as adverse conditions that meet the reporting requirements of the University of California (UC) Assurance Plan for LBNL or other reporting entities (e.g., U.S. Environmental Protection Agency, U.S. Department of Energy). Issues that are found as a result of a walk-around or workspace inspection that can be immediately corrected or fixed are exempt from the requirements of this document.

  10. Cryptographic Key Management System

    SciTech Connect (OSTI)

    No, author

    2014-02-21T23:59:59.000Z

    This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene#12;ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

  11. Energy Management Curriculum Starter Kit

    SciTech Connect (OSTI)

    Turner, W.C.

    1987-02-01T23:59:59.000Z

    The Energy Management Curriculum Starter Kit was designed to help engineering educators develop and teach energy management courses. Montana State University and Oklahoma State University courses are embodied in the model curriculum given. The curricula offered at many other universities throughout the United States are also presented. The kit was designed specifically to train engineering students to be good energy managers. Courses at both the undergraduate and postgraduate level are presented.

  12. Energy Management Without a Staff

    E-Print Network [OSTI]

    Dornbos, D. L. Sr.

    Energj Management Without a Staff David L. Dornbos, Sr. Manager, Facilities and "Energy Engineering Dept. Steelcase Inc. Grand Rapids, Michigan Our area assigned and central engineers are encouraged to design each project with energy... successful energy projects because of system and personnel familiarity and ownership. Our organization provides communication to all involved; management, production, maintenance and plant engineering (area and central) staff. The central specialists...

  13. Scientific and Technical Information Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-10-14T23:59:59.000Z

    The Order establishes requirements and responsibilities for managing DOE's scientific and technical information. Cancels DOE O 241.1. Canceled by DOE O 241.1B.

  14. Government Personal Property Asset Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1998-05-11T23:59:59.000Z

    Establishes procedures for managing Government personal property owned or leased by and in the custody of Department of Energy (DOE) Headquarters employees. Cancels HQ 1400.1.

  15. Earned Value Management System (EVMS)

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-03-13T23:59:59.000Z

    This Guide provides approaches for implementing the Earned Value Management System (EVMS) requirements of DOE O 413.3B. Cancels DOE G 413.3-10.

  16. Hazardous Waste Management (New Mexico)

    Broader source: Energy.gov [DOE]

    The New Mexico Environment Department's Hazardous Waste Bureau is responsible for the management of hazardous waste in the state. The Bureau enforces the rules established by the Environmental...

  17. FAQS Reference Guide – Emergency Management

    Broader source: Energy.gov [DOE]

    This reference guide addresses the competency statements in the January 2004 edition of DOE-STD-1177-2004, Emergency Management Functional Area Qualification Standard.

  18. OFFICE OF PROCUREMENT & ASSISTANCE MANAGEMENT

    Energy Savers [EERE]

    & ASSISTANCE MANAGEMENT INHERENTLY GOVERNMENTAL AND COMMERCIAL ACTIVITIES (IGCA) INVENTORY GUIDANCE 2012 Name Date Tel E-Mail Created by: Jeff Davis March 28, 2012...

  19. Solid Waste Management (South Dakota)

    Broader source: Energy.gov [DOE]

    This statute contains provisions for solid waste management systems, groundwater monitoring, liability for pollution, permitting, inspections, and provisions for waste reduction and recycling...

  20. Infor mation Management Governance Council

    Broader source: Energy.gov (indexed) [DOE]

    * Overseeing the development and management of the DOE cyber security strategy, architecture, and program. * Assuring that the DOE cyber security program is aligned with DOE...

  1. FAQS Reference Guide – Construction Management

    Broader source: Energy.gov [DOE]

    This reference guide addresses the competency statements in the March 2004 edition of DOE-STD-1180-2004, Construction Management Functional Area Qualification Standard.

  2. Section 10: Risk Management Concepts

    E-Print Network [OSTI]

    2014-12-04T23:59:59.000Z

    Dec 2, 2014 ... In this lesson we will discuss some concepts from risk management and insurance. We will go over the basic definitions and discuss some ...

  3. Active Technical Standards Managers List

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    TECHNICAL STANDARDS PROGRAM ASSIGNMENT TELEPHONEFAXEMAIL NAME DOE FACILITYADDRESS LOC CODE AU-30 Jeff D. Feit DOE Technical Standards Program, Manager U.S. Department of Energy...

  4. Optimization Online - Robust Production Management

    E-Print Network [OSTI]

    Vincent Guigues

    2011-02-23T23:59:59.000Z

    Feb 23, 2011 ... Abstract: The problem of production management can often be cast in the form ... We then give the quality of robust solutions obtained by using ...

  5. FACULTY OF SCIENCE FACULTY MANAGER

    E-Print Network [OSTI]

    Bristol, University of

    Foster, Ali Prescott, Meagan Puzacke Admin Assistant Anona Williams Senior Executive Assistant Emily Academic Administrator Indaka Weerasekera Student Administration Manager Karen Spencer UG Student

  6. Sandia National Laboratories: thermal management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    management 2013 Inverter Reliability Workshop On May 31, 2013, in Hosted by Sandia National Laboratories and the Electric Power Research Institute (EPRI) Inverter reliability...

  7. Stormwater Management Rules (New Jersey)

    Broader source: Energy.gov [DOE]

    This chapter establishes general requirements for stormwater management plans and stormwater control ordinances as well as content requirements and procedures for the adoption and implementation of...

  8. Solid Waste Management (North Carolina)

    Broader source: Energy.gov [DOE]

    The Solid Waste Program regulates safe management of solid waste through guidance, technical assistance, regulations, permitting, environmental monitoring, compliance evaluation and enforcement....

  9. LANSCE | Lujan Center | Data Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lujan Center Data Management Lujan Neutron Scattering Center Logo The Lujan Center within LANSCE utilizes a pulsed source and has a complement of 15 instruments. It maintains a...

  10. Page 1 of 2 Risk Management March 2012 Risk Management

    E-Print Network [OSTI]

    Page 1 of 2 Risk Management March 2012 Risk Management Supervisor's Vehicle Incident Report-Employee Volunteer Drivers License No. State of Issue UO Certification Date UO Driver Training Date Vehicle Information: License No. Make Model Year UO Vehicle # Motorpool Outside Rental Personal Vehicle Incident

  11. Integrating Knowledge Management and Human Resources via Skill Management

    E-Print Network [OSTI]

    Appelrath, Hans-Jürgen

    Integrating Knowledge Management and Human Resources via Skill Management Norbert Gronau. The human resources department can look for certain skills and compare the skills of an employee [Kreitmeier et al. 2000]. The company is able to save costs that otherwise apply to placing adverts for job

  12. Automated transportation management system (ATMS) software project management plan (SPMP)

    SciTech Connect (OSTI)

    Weidert, R.S., Westinghouse Hanford

    1996-05-20T23:59:59.000Z

    The Automated Transportation Management System (ATMS) Software Project Management plan (SPMP) is the lead planning document governing the life cycle of the ATMS and its integration into the Transportation Information Network (TIN). This SPMP defines the project tasks, deliverables, and high level schedules involved in developing the client/server ATMS software.

  13. Inconsistency Management in Software Engineering 1 INCONSISTENCY MANAGEMENT IN SOFTWARE

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    in the construction industry / Bin Chen. Ph.D. 2009 NF nanofiltration membrane characterization / Ahmed Saleh Al verification / Neil Pearson. M.Phil. 2008 #12; Design and optimisation of joints in a carbon fibre bicycle reservoir 'A' / Hussain Al-Hassani. M.Res. 2008 Chemical Engineering Tensile properties of polymeric

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    DOE Patents [OSTI]

    Rice, H.B.; McNair, R.C.; White, K.; Maugeri, T.

    1998-08-04T23:59:59.000Z

    A Computerized Training Management System (CTMS) is disclosed for providing a procedurally defined process that is employed to develop accreditable performance based training programs for job classifications that are sensitive to documented regulations and technical information. CTMS is a database that links information needed to maintain a five-phase approach to training-analysis, design, development, implementation, and evaluation independent of training program design. CTMS is designed using R-Base{trademark}, an-SQL compliant software platform. Information is logically entered and linked in CTMS. Each task is linked directly to a performance objective, which, in turn, is linked directly to a learning objective; then, each enabling objective is linked to its respective test items. In addition, tasks, performance objectives, enabling objectives, and test items are linked to their associated reference documents. CTMS keeps all information up to date since it automatically sorts, files and links all data; CTMS includes key word and reference document searches. 18 figs.

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    Rice, Harold B. (Franklin Furnace, OH); McNair, Robert C. (East Setauket, NY); White, Kenneth (Shirley, NY); Maugeri, Terry (Wading River, NY)

    1998-08-04T23:59:59.000Z

    A Computerized Training Management System (CTMS) for providing a procedurally defined process that is employed to develop accreditable performance based training programs for job classifications that are sensitive to documented regulations and technical information. CTMS is a database that links information needed to maintain a five-phase approach to training-analysis, design, development, implementation, and evaluation independent of training program design. CTMS is designed using R-Base.RTM., an-SQL compliant software platform. Information is logically entered and linked in CTMS. Each task is linked directly to a performance objective, which, in turn, is linked directly to a learning objective; then, each enabling objective is linked to its respective test items. In addition, tasks, performance objectives, enabling objectives, and test items are linked to their associated reference documents. CTMS keeps all information up to date since it automatically sorts, files and links all data; CTMS includes key word and reference document searches.

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    SciTech Connect (OSTI)

    Asante-Duah, D.K.

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    This book summarizes the generic principles of contaminated site management. The book walks the reader through contaminated site identification, risk assessment and the evaluation of remediation alternatives. The book is divided into two major sections, problem diagnosis and development of site restoration. In problem diagnosis, the general principles of site investigation are discussed, including the objectives and differences between tier 1,2, and 3 investigations. The principles of data collection and analysis are presented. A small quantitative discussion of statistical analysis is presented but in keeping with the objectives of the text is not sufficient comprehensive or detailed to provide much of a guide for the practitioner. Chapters on contaminant fate and transport processes and risk assessment help the reader understand the role of these issues in site investigation and remedial planning. A chapter is also included on elements of a site characterization activity, which summarizes some of the key considerations in conducting a site investigation.

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    This article is a brief discussion of management changes at the Westinghouse Hanford Corporation. A. LeMar Trego has relieved Thomas Anderson as president of WHC. This was in response to recent shortcomings in Westinghouse`s management of the environmental restoration and their failure to receive a $10M performance bonus.

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