National Library of Energy BETA

Sample records for manager coconino nf

  1. EA-1863: Vegetation Management on the Glen Canyon-Pinnacle Peak Transmission Lines Spanning the Coconino National Forest, Coconino County, Arizona

    Broader source: Energy.gov [DOE]

    DOE’s Western Area Power Administration is preparing this EA to evaluate the environmental impacts of updating the vegetation management and right-of-way maintenance program for Western’s Glen Canyon to Pinnacle Peak 345-kV transmission lines, which cross the Coconino National Forest, Coconino County, Arizona.

  2. EIS-0427: Grapevine Canyon Wind Project, Coconino County, Arizona

    Broader source: Energy.gov [DOE]

    This EIS evaluates the environmental impacts of a proposed wind energy generation project in Coconino County, Arizona, on privately owned ranch lands and trust lands administered by the Arizona State Land Department. The proposed project includes a new transmission tie-line that would cross lands administered by Coconino National Forest and interconnect with DOE’s Western Area Power Administration’s existing Glen Canyon-Pinnacle Peak transmission lines.

  3. 1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011 for comparison & final determination #12;3 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Neutrino Factory Mercury Pool Splash Mitigation V.B. Graves IDS Videoconference July 12, 2011 #12;2 Managed

  4. 1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09;3 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09 Cross Section to flow out the front of the cryostat #12;4 Managed by UT-Battelle for the U.S. Department of Energy NF

  5. Publication Date 4/1/2015 FEDERAL RECREATION AREA/SITE PHONE CITY STATE WEBSITE ANNUAL SENIOR ACCESS

    E-Print Network [OSTI]

    /coconino/contact/index.shtml YES YES YES Coconino NF - Peaks & Mormon Lake District 928-526-0866 Flagstaff

  6. Fossil vertebrate footprints in the Coconino Sandstone (Permian) of northern Arizona: Evidence for underwater origin

    SciTech Connect (OSTI)

    Brand, L.R.; Thu Tang (Loma Linda Univ., CA (United States))

    1991-12-01

    Numerous fossil vertebrate trackways in the Coconino Sandstone of northern Arizona exhibit several features that imply that these trackways were not made in subaerial conditions. Some trackways begin or end abruptly on undisturbed bedding planes, and in other trackways the individual prints are oriented in a different direction from that of the trackway. These features indicate buoyancy of the animals in water. The animals were swimming in the water part of the time and at other times walking on the substrate, and they were sometimes orienting upslope on the surface of the underwater dunes, while being drifted sideways by lateral currents. Observations on salamander locomotion in a sedimentation tank with flowing water support this model.

  7. TNAP, a Novel Repressor of NF-B-inducing Kinase, Suppresses NF-B Activation*

    E-Print Network [OSTI]

    Hu, Wen-Hui

    responses, oncogenesis, apoptosis, and neuronal signaling (1­5). To date two principal pathways for NF- B

  8. Correction to NF 3 , the greenhouse gas missing from Kyoto

    E-Print Network [OSTI]

    Prather, Michael J; Hsu, Juno

    2010-01-01

    J. Hsu (2008), NF 3 , the greenhouse gas missing from Kyoto,Correction to “NF 3 , the greenhouse gas missing from Kyoto”2010), Correction to “NF 3 , the greenhouse gas missing from

  9. NF kappa B expression and matrix metalloproteinase activity in hypertension

    E-Print Network [OSTI]

    Wu, Kwan-I

    2009-01-01

    without PDTC treatment by gelatin gel zymography. Chapter 2Labeling of NF-?B………………………………14 Gelatin Gel ZymographyPDTC treatment measured by gelatin zymography…………………34

  10. Erratum: NF3, the greenhouse gas missing from Kyoto (Geophysical Research Letters (2010) 37 (L11807))

    E-Print Network [OSTI]

    Prather, MJ; Hsu, J

    2010-01-01

    J. Hsu (2008), NF 3 , the greenhouse gas missing from Kyoto,Correction to “NF 3 , the greenhouse gas missing from Kyoto”2010), Correction to “NF 3 , the greenhouse gas missing from

  11. Cloning and expression of equine NF-kB2 

    E-Print Network [OSTI]

    Mirhosseini, Negin

    2009-05-15

    ........................ 51 xi LIST OF TABLES Page Table 1 Primers to generate full length NF-?B2... of the interaction between EIAV S2 and equine NF-?B in the yeast two hybrid system........................... 43 Table 7 Primers and probes for quantitative PCR.......................................... 48 1 CHAPTER I INTRODUCTION 1 Equine Infectious...

  12. EA-2008: Colorado River Storage Project Programmatic Operations and Maintenance Project; Coconino, Maricopa, Navajo, and Yavapai Counties (Arizona) and San Juan County (Utah)

    Broader source: Energy.gov [DOE]

    Western Area Power Administration is preparing an EA that assesses the potential environmental impacts of Western’s programmatic operations and management (O&M) process and an integrated vegetation management (IVM) program on the Colorado River Storage Project System. O&M activities would consist of aerial and ground patrols, regular and preventive maintenance, inspections and repairs, and road repair. The IVM program would remove vegetation to protect facilities from fire, control the spread of noxious weeds to protect environmental quality, establish and maintain stable, low-growing plant communities in the ROW, and activities for public and worker safety around transmission lines and other facilities.

  13. DOE/EA-2008: Colorado River Storage Project Programmatic Operations and Maintenance Project; Coconino, Maricopa, Navajo, and Yavapai Counties (Arizona) and San Juan County (Utah)

    Broader source: Energy.gov [DOE]

    Western Area Power Administration is preparing an EA that assesses the potential environmental impacts of Western’s programmatic operations and management (O&M) process and an integrated vegetation management (IVM) program on the Colorado River Storage Project System. O&M activities would consist of aerial and ground patrols, regular and preventive maintenance, inspections and repairs, and road repair. The IVM program would remove vegetation to protect facilities from fire, control the spread of noxious weeds to protect environmental quality, establish and maintain stable, low-growing plant communities in the ROW, and activities for public and worker safety around transmission lines and other facilities.

  14. Effects of water chemistry on NF/RO membrane structure and performance

    E-Print Network [OSTI]

    Mo, Yibing

    2013-01-01

    potable water and seawater desalination. NF/RO are effectivemembranes under seawater conditions, Desalination, 247 (

  15. NF 3 , the greenhouse gas missing from Kyoto

    E-Print Network [OSTI]

    Prather, Michael J; Hsu, Juno

    2008-01-01

    of high-GWP, long-lived, greenhouse gases like NF 3 shouldbe included in the national greenhouse gas inventories onceto expand the list of greenhouse gases for the second

  16. NF-?B Fans the Flames of Lung Carcinogenesis

    E-Print Network [OSTI]

    Jacks, Tyler E.

    This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-?B and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating ...

  17. Mercury Chamber NF-IDS Meeting

    E-Print Network [OSTI]

    McDonald, Kirk

    windows (upstream and downstream) ­ Shell cooling? #12;4 Managed by UT-Battelle for the U.S. Department Upstream View Downstream View #12;6 Managed by UT-Battelle for the U.S. Department of Energy Mercury Isometrics Downstream Beam Window Drainage Notch Overflow & Maintenance Drains Nozzle, Beam Pipe, Vents

  18. Haploid reporter screens aimed at identification of NF-kappaB regulators

    E-Print Network [OSTI]

    Lee, Clarissa Ci

    2014-01-01

    Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such ...

  19. management

    National Nuclear Security Administration (NNSA)

    5%2A en Management and Budget http:www.nnsa.energy.govaboutusouroperationsmanagementandbudget

  20. Finite density phase transition of QCD with $N_f=4$ and $N_f=2$ using canonical ensemble method

    E-Print Network [OSTI]

    Anyi Li; Andrei Alexandru; Keh-Fei Liu; Xiangfei Meng

    2010-10-01

    In a progress toward searching for the QCD critical point, we study the finite density phase transition of $N_f = 4$ and 2 lattice QCD at finite temperature with the canonical ensemble approach. We develop a winding number expansion method to accurately project out the particle number from the fermion determinant which greatly extends the applicable range of baryon number sectors to make the study feasible. Our lattice simulation was carried out with the clover fermions and improved gauge action. For a given temperature, we calculate the baryon chemical potential from the canonical approach to look for the mixed phase as a signal for the first order phase transition. In the case of $N_f=4$, we observe an "S-shape" structure in the chemical potential-density plane due to the surface tension of the mixed phase in a finite volume which is a signal for the first order phase transition. We use the Maxwell construction to determine the phase boundaries for three temperatures below $T_c$. The intersecting point of the two extrapolated boundaries turns out to be at the expected first order transition point at $T_c$ with $\\mu = 0$. This serves as a check for our method of identifying the critical point. We also studied the $N_f =2$ case, but do not see a signal of the mixed phase for temperature as low as 0.83 $T_c$.

  1. Managed by UT-Battelle for the Department of Energy

    E-Print Network [OSTI]

    McDonald, Kirk

    Managed by UT-Battelle for the Department of Energy Design and Operational Features of a Mercury CERN #12;2 Managed by UT-Battelle for the Department of Energy Contributors · Tom McManamy, Chief Dec 08 #12;3 Managed by UT-Battelle for the Department of Energy NF-IDS Meeting 15 Dec 08 Outline

  2. Managed by UT-Battelle for the Department of Energy

    E-Print Network [OSTI]

    McDonald, Kirk

    Managed by UT-Battelle for the Department of Energy Neutrino Factory Mercury Containment Concepts V;2 Managed by UT-Battelle for the Department of Energy HPT Workshop, 6 Nov 2008 Outline · Neutrino Factory.14 Dimensions in cm #12;6 Managed by UT-Battelle for the Department of Energy HPT Workshop, 6 Nov 2008 NF Hg Jet

  3. Response and Resistance to NF-?B Inhibitors in Mouse Models of Lung Adenocarcinoma

    E-Print Network [OSTI]

    Xue, Wen

    Lung adenocarcinoma is a leading cause of cancer death worldwide. We recently showed that genetic inhibition of the NF-?B pathway affects both the initiation and the maintenance of lung cancer, identifying this pathway as ...

  4. Requirement for NF-?B signalling in a mouse model of lung adenocarcinoma

    E-Print Network [OSTI]

    Meylan, Etienne

    NF-?B transcription factors function as crucial regulators of inflammatory and immune responses as well as of cell survival. They have also been implicated in cellular transformation and tumorigenesis. However, despite ...

  5. Interleukin-6 upregulates paraoxonase 1 gene expression via an AKT/NF-?B-dependent pathway

    SciTech Connect (OSTI)

    Cheng, Chi-Chih [Department of Research, Taichung Veterans General Hospital, Taichung, Taiwan (China)] [Department of Research, Taichung Veterans General Hospital, Taichung, Taiwan (China); Hsueh, Chi-Mei [Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan (China)] [Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan (China); Chen, Chiu-Yuan [Graduate Institute of Natural Healing Sciences, Nanhua University, Chiayi, Taiwan (China)] [Graduate Institute of Natural Healing Sciences, Nanhua University, Chiayi, Taiwan (China); Chen, Tzu-Hsiu, E-mail: hsiu@mail.chna.edu.tw [Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan (China)] [Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan (China); Hsu, Shih-Lan, E-mail: h2326@vghtc.gov.tw [Department of Research, Taichung Veterans General Hospital, Taichung, Taiwan (China) [Department of Research, Taichung Veterans General Hospital, Taichung, Taiwan (China); Department of Applied Chemistry, National Chi Nan University, Puli, Nantou, Taiwan (China)

    2013-07-19

    Highlights: •IL-6 could induce PON1 gene expression. •IL-6 increased NF-?B protein expression and NF-?B-p50 and -p65 subunits nuclear translocation. •IL-6-induced PON1 up-regulation was through an AKT/NF-?B pathway. -- Abstract: The aim of this study is to investigate the relationship between paraoxonase 1 (PON1) and atherosclerosis-related inflammation. In this study, human hepatoma HepG2 cell line was used as a hepatocyte model to examine the effects of the pro-inflammatory cytokines on PON1 expression. The results showed that IL-6, but not TNF-? and IL-1?, significantly increased both the function and protein level of PON1; data from real-time RT-PCR analysis revealed that the IL-6-induced PON1 expression occurred at the transcriptional level. Increase of I?B kinase activity and I?B phosphorylation, and reduction of I?B protein level were also observed in IL-6-treated HepG2 cells compared with untreated culture. This event was accompanied by increase of NF-?B-p50 and -p65 nuclear translocation. Moreover, treatment with IL-6 augmented the DNA binding activity of NF-?B. Furthermore, pharmacological inhibition of NF-?B activation by PDTC and BAY 11-7082, markedly suppressed the IL-6-mediated PON1 expression. In addition, IL-6 increased the levels of phosphorylated protein kinase B (PKB, AKT). An AKT inhibitor LY294002 effectively suppressed IKK/I?B/NF-?B signaling and PON1 gene expression induced by IL-6. Our findings demonstrate that IL-6 upregulates PON1 gene expression through an AKT/NF-?B signaling axis in human hepatocyte-derived HepG2 cell line.

  6. A test of first order scaling in Nf=2 QCD

    E-Print Network [OSTI]

    G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

    2007-09-30

    We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

  7. Development of NF3 Deposit Removal Technology for the Portsmouth Gaseous Diffusion Plant

    SciTech Connect (OSTI)

    Scheele, R.D.; McNamara, B.K.; Rapko, B.M.; Edwards, M.K.; Kozelisky, A.E.; Daniel, R.C. [Battelle Pacific Northwest Division, PO Box 999, Battelle Blvd, Richland, Washington 99352 (United States); McSweeney, T.I.; Maharas, S.J.; Weaver, P.J.; Iwamasa, K.J. [Battelle Columbus Operations, 505 King Avenue, Columbus, Ohio 43201 (United States); Kefgen, R.B. [WASTREN, Inc., 1864 Shyville Road, Piketon, Ohio 45661 (United States)

    2006-07-01

    This paper summarizes the Battelle, Stoller, and WASTREN (BSW) team's efforts, to date, in support of the United States Department of Energy's plans to remove uranium and technetium deposits before decommissioning the Portsmouth Gaseous Diffusion Plant. The BSW team investigated nitrogen trifluoride (NF{sub 3}) as a safer yet effective alternative gaseous treatment to the chlorine trifluoride (ClF{sub 3})-elemental fluorine (F{sub 2}) treatment currently used to remove uranium and technetium deposits from the uranium enrichment cascade. Both ClF{sub 3} and F{sub 2} are highly reactive, toxic, and hazardous gases, while NF{sub 3}, although toxic [1], is no more harmful than moth balls [2]. BSW's laboratory thermo-analytical and laboratory-scale prototype studies with NF{sub 3} established that thermal NF{sub 3} can effectively remove likely and potential uranium (UO{sub 2}F{sub 2} and UF{sub 4}) and technetium deposits (a surrogate deposit material, TcO{sub 2}, and pertechnetates) by conversion to volatile compounds. Our engineering evaluations suggest that NF{sub 3}'s effectiveness could be enhanced by combining with a lesser concentration of ClF{sub 3}. BSW's and other's studies indicate compatibility with Portsmouth materials of construction (aluminum, copper, and nickel). (authors)

  8. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  9. CARD6 Is a Modulator of NF-B Activation by Nod1-and Cardiak-mediated Pathways*

    E-Print Network [OSTI]

    CARD6 Is a Modulator of NF- B Activation by Nod1- and Cardiak-mediated Pathways* Received specific binding of this CARD6-encoding protein to Nod1 (CARD4), Cardiak (Rip2/Rick), NAC (NALP1/DEFCAP implicated in NF- B and caspase-1 activation but not to other CARD family proteins. Cardiak and Nod1 (but

  10. NF-?B1 Inhibits TLR-Induced IFN-? Production in Macrophages Through TPL-2-dependent ERK Activation

    E-Print Network [OSTI]

    Yang, Huei-Ting

    Although NF-?B1 p50/p105 has critical roles in immunity, the mechanism by which NF-?B1 regulates inflammatory responses is unclear. In this study, we analyzed the gene expression profile of LPS-stimulated Nfkb1?/? macrophages ...

  11. Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB

    E-Print Network [OSTI]

    Nguyen, Hung Nhat

    2011-01-01

    The nuclear factor-kappa B (NF-kappaB) family of transcription factors play a pivotal role in the inflammatory and immune responses, as well as cell growth and survival. Since its discovery 25 years ago, NF-kappaB has ...

  12. VALIDATION OF EAF-2010 (N,G) AND (N,F) REACTIONS 1. INTEGRAL ACTIVATION DATA BASE FOR (N,G) AND (N,F) REACTIONS

    E-Print Network [OSTI]

    VALIDATION OF EAF-2010 (N,G) AND (N,F) REACTIONS 1. INTEGRAL ACTIVATION DATA BASE FOR (N,G) AND (N IRRAGIAMENTO SIC A FNG, supplied by M Pillon used at FNG for integral exps [175 group Vitamin-E weighting Pillon used at FNG for integral exps [175 group Vitamin-E weighting]. UKAEA-FUS-547 7 fng_tung.asc 175

  13. Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1 Machine tools : Safety : Hydraulic presses

    E-Print Network [OSTI]

    Association Française de Normalisation. Paris

    2009-01-01

    Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1

  14. Microstructural Evolution in Two Variants of NF709 at 1023 and 1073 K

    E-Print Network [OSTI]

    Cambridge, University of

    and that could invalidate the extrapolations of short-term creep test data, and to identify any precipitates.K.D.H. BHADESHIA The microstructural state of two grades of the creep-resistant austenitic stainless steels NF709 regarded as one of the best austenitic steels for elevated temperature applications because of its creep

  15. Coconino County, Arizona: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePower Ventures Jump to: navigation, searchClover HillCobalt

  16. Purinergic signaling is required for fluid shear stress-induced NF-{kappa}B translocation in osteoblasts

    SciTech Connect (OSTI)

    Genetos, Damian C., E-mail: dgenetos@ucdavis.edu [Department of Anatomy, Cell Biology, and Physiology, School of Veterinary Medicine, University of California, Davis, CA (United States); Karin, Norman J. [Cell Biology and Biochemistry, Pacific Northwest National Laboratory, Richland, WA (United States)] [Cell Biology and Biochemistry, Pacific Northwest National Laboratory, Richland, WA (United States); Geist, Derik J. [Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN (United States)] [Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN (United States); Donahue, Henry J. [Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Pennsylvania State College of Medicine, Hershey, PA (United States)] [Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Pennsylvania State College of Medicine, Hershey, PA (United States); Duncan, Randall L. [Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN (United States)] [Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN (United States)

    2011-04-01

    Fluid shear stress regulates gene expression in osteoblasts, in part by activation of the transcription factor NF-{kappa}B. We examined whether this process was under the control of purinoceptor activation. MC3T3-E1 osteoblasts under static conditions expressed the NF-{kappa}B inhibitory protein I{kappa}B{alpha} and exhibited cytosolic localization of NF-{kappa}B. Under fluid shear stress, I{kappa}B{alpha} levels decreased, and concomitant nuclear localization of NF-{kappa}B was observed. Cells exposed to fluid shear stress in ATP-depleted medium exhibited no significant reduction in I{kappa}B{alpha}, and NF-{kappa}B remained within the cytosol. Similar results were found using oxidized ATP or Brilliant Blue G, P2X{sub 7} receptor antagonists, indicating that the P2X{sub 7} receptor is responsible for fluid shear-stress-induced I{kappa}B{alpha} degradation and nuclear accumulation of NF-{kappa}B. Pharmacologic blockage of the P2Y6 receptor also prevented shear-induced I{kappa}B{alpha} degradation. These phenomena involved neither ERK1/2 signaling nor autocrine activation by P2X{sub 7}-generated lysophosphatidic acid. Our results suggest that fluid shear stress regulates NF-{kappa}B activity through the P2Y{sub 6} and P2X{sub 7} receptor.

  17. Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface

    SciTech Connect (OSTI)

    Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H.

    2009-07-01

    To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

  18. Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB

    E-Print Network [OSTI]

    Dai, Yao; Jeffrey, Tang; Wenhua, Xiaojie; Meng, Yang; Burstein, Ezra; Lawrence, Theodore S.; Xu, Liang

    2010-12-10

    Background Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC) with constitutive NF-?B activation. ...

  19. Linear noise approximation of noise-induced oscillation in NF-?B signaling network

    E-Print Network [OSTI]

    Jaewook Joo

    2010-10-08

    NF-{\\kappa}B, one of key regulators of inflammation, apoptosis, and differentiation, was found to have noisy oscillatory shuttling between the nucleus and the cytoplasm in single cells when cells are stimulated by cytokine TNF{\\alpha}. We present the analytical analysis which uncovers the underlying physical mechanisms of this spectacular noise-induced transition in biological networks. Starting with the master equation describing both signaling and transcription events in NF-{\\kappa}B signaling network, we derived the macroscopic and the Fokker-Planck equations by using van Kampen's sysem size expansion. Using the noise-induced oscillatory signatures present in the power spectrum, we constructed the two-dimensional phase diagram where the noise-induced oscillation emerges in the dynamically stable parameter space.

  20. Omentin inhibits TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via ERK/NF-{kappa}B pathway

    SciTech Connect (OSTI)

    Zhong, Xia, E-mail: zhongxia1977@126.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Li, Xiaonan; Liu, Fuli; Tan, Hui [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Shang, Deya, E-mail: wenhuashenghuo1@163.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)

    2012-08-24

    Highlights: Black-Right-Pointing-Pointer Omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Black-Right-Pointing-Pointer Omentin reduces expression of ICAM-1 and VCAM-1 induced by TNF-{alpha} in HUVECs. Black-Right-Pointing-Pointer Omentin inhibits TNF-{alpha}-induced ERK and NF-{kappa}B activation in HUVECs. Black-Right-Pointing-Pointer Omentin supreeses TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 via ERK/NF-{kappa}B pathway. -- Abstract: In the present study, we investigated whether omentin affected the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in tumor necrosis factor-{alpha} (TNF-{alpha}) induced human umbilical vein endothelial cells (HUVECs). Our data showed that omentin decreased TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 in HUVECs. In addition, omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Further, we found that omentin inhibited TNF-{alpha}-activated signal pathway of nuclear factor-{kappa}B (NF-{kappa}B) by preventing NF-{kappa}B inhibitory protein (I{kappa}B{alpha}) degradation and NF-{kappa}B/DNA binding activity. Omentin pretreatment significantly inhibited TNF-{alpha}-induced ERK activity and ERK phosphorylation in HUVECs. Pretreatment with PD98059 suppressed TNF-{alpha}-induced NF-{kappa}B activity. Omentin, NF-kB inhibitor (BAY11-7082) and ERK inhibitor (PD98059) reduced the up-regulation of ICAM-1 and VCAM-1 induced by TNF-{alpha}. These results suggest that omentin may inhibit TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via blocking ERK/NF-{kappa}B pathway.

  1. Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business

    SciTech Connect (OSTI)

    Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

    2011-02-01

    This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

  2. MC/NF TARGET SHIELDING STUDIES. NICHOLAS SOUCHLAS (10/29/2010)

    E-Print Network [OSTI]

    McDonald, Kirk

    MC/NF TARGET SHIELDING STUDIES. NICHOLAS SOUCHLAS (10/29/2010) 1 #12;Energy deposition from MARS, MARS+MCNP codes. STANDARD (STUDY II) GEOMETRY. STANDARD SHIELDING (80%WC+20% H2O). 4MW proton beamW to 50 kW in total power. 4 24 GeV 8 GeV #12;OFF/ON SHIELDING, DIFFERENT NEUTRON ENERGY CUTOFFS. 5 #12

  3. IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHussein KhalilResearch &ENERGYWhoCELL WALLS4,IDRMSIDS-NF

  4. Network Management Network Management

    E-Print Network [OSTI]

    Giaccone, Paolo

    Network Management Pag. 1 Network Management Network management and QoS provisioning - 1Andrea of this license visit: http://creativecommons.org/licenses/by-nc- /3 0/ Network management and QoS provisioning ­ Chapter 9, Network Management, of the book Jim Kurose, Keith Ross, Computer Networking, A Top Down

  5. Management Plan Management Plan

    E-Print Network [OSTI]

    Management Plan Management Plan "Management and restoration programs for native salmonids have communities" J. Lichatowich et al. 1998. A Conceptual Foundation for the Management of Native Salmonids in the Deschutes River. The Management Plan consists of five elements described in the Council's program: 1

  6. FY13 Summary Report on the Augmentation of the Spent Fuel Composition Dataset for Nuclear Forensics: SFCOMPO/NF

    SciTech Connect (OSTI)

    Brady Raap, Michaele C.; Lyons, Jennifer A.; Collins, Brian A.; Livingston, James V.

    2014-03-31

    This report documents the FY13 efforts to enhance a dataset of spent nuclear fuel isotopic composition data for use in developing intrinsic signatures for nuclear forensics. A review and collection of data from the open literature was performed in FY10. In FY11, the Spent Fuel COMPOsition (SFCOMPO) excel-based dataset for nuclear forensics (NF), SFCOMPO/NF was established and measured data for graphite production reactors, Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs) were added to the dataset and expanded to include a consistent set of data simulated by calculations. A test was performed to determine whether the SFCOMPO/NF dataset will be useful for the analysis and identification of reactor types from isotopic ratios observed in interdicted samples.

  7. ABD56 causes osteoclast apoptosis by inhibiting the NF{kappa}B and ERK pathways

    SciTech Connect (OSTI)

    Idris, Aymen [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Mrak, Emanuela [Bone Metabolic Unit, Scientific Institute H San Raffaele, via Olgettina 60, 20132 Milano (Italy); Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Greig, Iain [Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD (United Kingdom); Guidobono, Francesca [Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Ralston, Stuart H. [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Hof, Rob van 't [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom)], E-mail: rvanthof@staffmail.ed.ac.uk

    2008-06-20

    We have previously shown that the biphenylcarboxylic acid butanediol ester (ABD56) inhibits osteoclast formation and activity in vitro and in vivo. However, the mechanism of action of this compound is unknown. ABD56 inhibited osteoclast formation and caused osteoclast apoptosis, but had no effects on osteoblasts or macrophages. As the NF{kappa}B and MAPK pathways are essential for osteoclast formation and survival, we studied the effects of ABD56 on these pathways. ABD56 caused phosphorylation of p38, JNK and nuclear translocation of c-jun in osteoclasts. ABD56-induced apoptosis was prevented by the caspase inhibitor zVAD-fmk but was not prevented by the p38- or JNK-inhibitors. ABD56 completely abolished RANKL-induced I{kappa}B and ERK1/2 phosphorylation. Increasing the amount of RANKL partially rescued ABD56-induced apoptosis, indicating that the apoptosis is most probably due to the inhibition of survival signals such as ERK and NF{kappa}B, rather than activation of the p38 or Jnk MAPK pathways.

  8. 5) Management 5) Management

    E-Print Network [OSTI]

    Nowak, Robert S.

    5) Management c) Control #12;5) Management c) Control Prioritizing control ­ From Hiebert in Luken & Thieret (1997) · Types of information utilized Ecological impacts #12;5) Management c) Control impacts Economic impacts #12;5) Management c) Control Prioritizing control ­ From Hiebert in Luken

  9. Network Management Network Management

    E-Print Network [OSTI]

    Giaccone, Paolo

    Network Management Pag. 1 Network Management Andrea Bianco Telecommunication Network Group Network management and QoS provisioning - 1Andrea Bianco ­ TNG group - Politecnico di Torino Telecommunication management and QoS provisioning - 2Andrea Bianco ­ TNG group - Politecnico di Torino Stanford, California

  10. Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after

    E-Print Network [OSTI]

    Freger, Viatcheslav "Slava"

    2005-01-01

    to hot 20% sulfuric acid solutions for various times. Swelling and morphological changes measured Nanofiltration (NF) membranes represent a class of mem- branes with capabilities to selectively separate low- sulfone, which support an ultra-thin selective layer a few tens to a few hundred of nanometers thick

  11. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-{kappa}B-mediated survival signaling

    SciTech Connect (OSTI)

    Leskinen, Markus J. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Heikkilae, Hanna M. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Speer, Mei Y. [Bioengineering Department, University of Washington, Seattle, WA 98195 (United States); Hakala, Jukka K. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Laine, Mika [Department of Medicine, Helsinki University Central Hospital and Minerva Institute for Medical Research, Helsinki (Finland); Kovanen, Petri T. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Lindstedt, Ken A. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland)]. E-mail: ken.lindstedt@wri.fi

    2006-05-01

    Chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (SMCs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and Akt dephosphorylation, which are necessary for cell adhesion and survival. However, the molecular mechanisms of chymase-mediated apoptosis downstream of Akt have remained elusive. Here, we show by means of RT-PCR, Western blotting, EMSA, immunocytochemistry and confocal microscopy, that chymase induces SMC apoptosis by disrupting NF-{kappa}B-mediated survival signaling. Following chymase treatment, the translocation of active NF-{kappa}B/p65 to the nucleus was partly abolished and the amount of nuclear p65 was reduced. Pretreatment of SMCs with chymase also inhibited LPS- and IL-1{beta}-induced nuclear translocation of p65. The chymase-induced degradation of p65 was mediated by active caspases. Loss of NF-{kappa}B-mediated transactivation resulted in downregulation of bcl-2 mRNA and protein expression, leading to mitochondrial swelling and release of cytochrome c. The apoptotic process involved activation of both caspase 9 and caspase 8. The results reveal that, by disrupting the NF-{kappa}B-mediated survival-signaling pathway, activated chymase-secreting mast cells can mediate apoptosis of cultured arterial SMCs. Since activated mast cells colocalize with apoptotic SMCs in vulnerable areas of human atherosclerotic plaques, they may participate in the weakening and rupture of atherosclerotic plaques.

  12. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kB pathways

    E-Print Network [OSTI]

    Abecasis, Goncalo

    Genome-wide scan reveals association of psoriasis with IL-23 and NF-kB pathways Rajan P Nair1 Abecasis4,20, for the Collaborative Association Study of Psoriasis18 Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped

  13. Modeling green fluorescent protein transcription, translation and modification as a method to obtain NF-kappaB activation profiles 

    E-Print Network [OSTI]

    Laible, Allyson Marie

    2009-05-15

    that fluorescence increases up to 24 hours after an initial delay of approximately four hours. The fluorescence data was also used to develop a model describing significant events leading to NF-?B activation and GFP expression. In addition, a model describing...

  14. Decreasing NF-?B Expression Enhances Odontoblastic Differentiation and Collagen Expression in Dental Pulp Stem Cells Exposed to Inflammatory Cytokines 

    E-Print Network [OSTI]

    Hozhabri, Neda S. T.; Benson, M. Douglas; Vu, Michael D.; Patel, Rinkesh H.; Martinez, Rebecca M.; Nakhaie, Fatemeh N.; Kim, Harry K. W.; Varanasi, Venu G.

    2015-01-28

    Decreasing NF-?B Expression Enhances Odontoblastic Differentiation and Collagen Expression in Dental Pulp Stem Cells Exposed to Inflammatory Cytokines Neda S. T. Hozhabri1, M. Douglas Benson1, Michael D. Vu1, Rinkesh H. Patel1, Rebecca M. Martinez1, Fatemeh N...

  15. Ascorbic acid suppresses endotoxemia and NF-?B signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

    SciTech Connect (OSTI)

    Abhilash, P.A.; Harikrishnan, R.; Indira, M.

    2014-01-15

    Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-?B activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKK? and the protein expressions of phospho-I?B?, NF-?B, TNF-?, TGF-?{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers ?-SMA, ?{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-?B activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKK?, which decreased the activation of NF-?B and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: • Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. • Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. • Ascorbic acid reduces endotoxemia, NF-?B activation and proinflammatory cytokines. • AA's action is by inhibition of SIBO, IKK? and alteration of intestinal permeability. • This might have led to suppression of HSCs activation and liver fibrosis.

  16. Thermal Reactions of Uranium Metal, UO2, U3O8, UF4, and UO2F2 with NF3 to Produce UF6

    SciTech Connect (OSTI)

    McNamara, Bruce K.; Scheele, Randall D.; Kozelisky, Anne E.; Edwards, Matthew K.

    2009-11-01

    he objective of this paper is to demonstrate that NF3 fluorinates uranium metal, UO2, UF4, UO3, U3O8, and UO2F2•2H2O to produce the volatile UF6 at temperatures between 100 and 500?C. Thermogravimetric reaction profiles are described that reflect changes in the uranium oxidation state and discrete chemical speciation. Differences in the onset temperatures for each system indicate that NF3-substrate interactions are important for the temperature at which NF3 reacts: U metal > UO3 > UO2 > UO2F2 > UF4 and in fact may indicate different fluorination mechanisms for these various substrates. These studies demonstrate that NF3 is a potential replacement fluorinating agent in the existing nuclear fuel cycle and in oft-proposed actinide volatility reprocessing.

  17. TCR and CD28 activate the transcription factor NF- B in T-cells viadistinct adaptor signaling complexes

    E-Print Network [OSTI]

    Thaker, Youg Raj; Schneider, Helga; Rudd, Christopher E.

    2014-10-23

    Article history: Received 19 A Received in re Accepted 15 O Available onlin Keywords: Adaptors ADAP VAV-1 GRB-2 NF-?B ed fo nd CD ng T- n wit ?B in F-?B p?/? m Over-expression of ADAP or its binding partner SKAP1 failed to enhance anti-CD28... to CD28 addition, Tu can deliver complexes co-operate Rac-1 and m Despite ponents of T-cells have various kno 170F) mice that the TC the NF-?B p that the CD ent signalin 2. Materia 2.1. Mice an DO11.10 (kindly pro School of M Dr. Erik Pe housed und...

  18. Nmero Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias

    E-Print Network [OSTI]

    Baia, Margarida

    Sheet1 Page 1 Número Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias 53515 Jorge Branco 55774 João 70100 Catarina Ferreira 70146 Mariana Castro 70364 Nuno Gaspar 70524 António Grego 10 2 5 70934 João.2 2 15 78167 Afonso Sarmento 13.8 8.3 7.6 2 12 78175 Carlos Martins 14.3 12.6 11 2 14 78183 Ana

  19. Etching of UO{sub 2} in NF{sub 3} RF Plasma Glow Discharge

    SciTech Connect (OSTI)

    John M. Veilleux

    1999-08-01

    A series of room temperature, low pressure (10.8 to 40 Pa), low power (25 to 210 W) RF plasma glow discharge experiments with UO{sub 2} were conducted to demonstrate that plasma treatment is a viable method for decontaminating UO{sub 2} from stainless steel substrates. Experiments were conducted using NF{sub 3} gas to decontaminate depleted uranium dioxide from stainless-steel substrates. Depleted UO{sub 2} samples each containing 129.4 Bq were prepared from 100 microliter solutions of uranyl nitrate hexahydrate solution. The amorphous UO{sub 2} in the samples had a relatively low density of 4.8 gm/cm{sub 3}. Counting of the depleted UO{sub 2} on the substrate following plasma immersion was performed using liquid scintillation counting with alpha/beta discrimination due to the presence of confounding beta emitting daughter products, {sup 234}Th and {sup 234}Pa. The alpha emission peak from each sample was integrated using a gaussian and first order polynomial fit to improve quantification. The uncertainties in the experimental measurement of the etched material were estimated at about {+-} 2%. Results demonstrated that UO{sub 2} can be completely removed from stainless-steel substrates after several minutes processing at under 200 W. At 180 W and 32.7 Pa gas pressure, over 99% of all UO{sub 2} in the samples was removed in just 17 minutes. The initial etch rate in the experiments ranged from 0.2 to 7.4 {micro}m/min. Etching increased with the plasma absorbed power and feed gas pressure in the range of 10.8 to 40 Pa. A different pressure effect on UO{sub 2} etching was also noted below 50 W in which etching increased up to a maximum pressure, {approximately}23 Pa, then decreased with further increases in pressure.

  20. A (P)HMC algorithm for N_f = 2 + 1 + 1 flavours of twisted mass fermions

    E-Print Network [OSTI]

    T. Chiarappa; R. Frezzotti; C. Urbach

    2005-09-27

    We present a detailed design of a (P)HMC simulation algorithm for N_f = 2 + 1 + 1 maximally twisted Wilson quark flavours. The algorithm retains even/odd and mass-shift preconditionings combined with multiple Molecular Dynamics time scales for both the light mass degenerate, u and d, quarks and the heavy mass non-degenerate, s and c, quarks. Various non-standard aspects of the algorithm are discussed, among which those connected to the use of a polynomial approximation for the inverse (square root of the squared) Dirac matrix in the s and c quark sector.

  1. Hadron-Hadron Interactions from $N_f=2+1+1$ Lattice QCD: isospin-2 $??$ scattering length

    E-Print Network [OSTI]

    C. Helmes; C. Jost; B. Knippschild; C. Liu; J. Liu; L. Liu; C. Urbach; M. Ueding; Z. Wang; M. Werner

    2015-06-01

    We present results for the $I=2$ $\\pi\\pi$ scattering length using $N_f=2+1+1$ twisted mass lattice QCD for three values of the lattice spacing and a range of pion mass values. Due to the use of Laplacian Heaviside smearing our statistical errors are reduced compared to previous lattice studies. A detailed investigation of systematic effects such as discretisation effects, volume effects, and pollution of excited and thermal states is performed. After extrapolation to the physical point using chiral perturbation theory at NLO we obtain $M_\\pi a_0=-0.0442(2)_\\mathrm{stat}(^{+4}_{-0})_\\mathrm{sys}$.

  2. Determination of c_sw in N_f=3+1 Lattice QCD with massive Wilson fermions

    E-Print Network [OSTI]

    Patrick Fritzsch; Rainer Sommer; Felix Stollenwerk; Ulli Wolff

    2015-01-27

    We develop a strategy for the non-perturbative determination of the O(a)-improvement coefficient c_sw for Wilson fermions with massive sea quarks. The improvement condition is defined via the PCAC relation in the Schr\\"odinger functional. It is imposed along a line of constant physics designed to be close to the correct mass of the charm quark. The numerical work uses the tree-level improved L\\"uscher-Weisz gauge action in N_f=3+1 Lattice QCD.

  3. Angiotensin II modulates interleukin-1{beta}-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-{kappa}B crosstalk

    SciTech Connect (OSTI)

    Xu, Shanqin [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Zhi, Hui [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)] [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States); Hou, Xiuyun [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Jiang, Bingbing, E-mail: bjiang1@rics.bwh.harvard.edu [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States) [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)

    2011-07-08

    Highlights: {yields} We examine how angiotensin II modulates ERK-NF-{kappa}B crosstalk and gene expression. {yields} Angiotensin II suppresses IL-1{beta}-induced prolonged ERK and NF-{kappa}B activation. {yields} ERK-RSK1 signaling is required for IL-1{beta}-induced prolonged NF-{kappa}B activation. {yields} Angiotensin II modulates NF-{kappa}B responsive genes via regulating ERK-NF-{kappa}B crosstalk. {yields} ERK-NF-{kappa}B crosstalk is a novel mechanism regulating inflammatory gene expression. -- Abstract: Angiotensin II is implicated in cardiovascular diseases, which is associated with a role in increasing vascular inflammation. The present study investigated how angiotensin II modulates vascular inflammatory signaling and expression of inducible nitric oxide synthase (iNOS) and vascular cell adhesion molecule (VCAM)-1. In cultured rat aortic vascular smooth muscle cells (VSMCs), angiotensin II suppressed interleukin-1{beta}-induced prolonged phosphorylation of extracellular signal-regulated kinase (ERK) and ribosomal S6 kinase (RSK)-1, and nuclear translocation of nuclear factor (NF)-{kappa}B, leading to decreased iNOS but enhanced VCAM-1 expression, associated with an up-regulation of mitogen-activated protein kinase phosphatase-1 expression. Knock-down of RSK1 selectively down regulated interleukin-1{beta}-induced iNOS expression without influencing VCAM-1 expression. In vivo experiments showed that interleukin-1{beta}, iNOS, and VCAM-1 expression were detectable in the aortic arches of both wild-type and apolipoprotein E-deficient (ApoE{sup -/-}) mice. VCAM-1 and iNOS expression were higher in ApoE{sup -/-} than in wild type mouse aortic arches. Angiotensin II infusion (3.2 mg/kg/day, for 6 days, via subcutaneous osmotic pump) in ApoE{sup -/-} mice enhanced endothelial and adventitial VCAM-1 and iNOS expression, but reduced medial smooth muscle iNOS expression associated with reduced phosphorylation of ERK and RSK-1. These results indicate that angiotensin II can differentially modulate inflammatory gene expression in aortic smooth muscle cells through influencing ERK-NF-{kappa}B crosstalk, which may contribute to angiotensin II-induced inflammatory disorders related to cardiovascular diseases.

  4. Conference Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-11-03

    To establish requirements and responsibilities with respect to managing conferences sponsored by the Department of Energy (DOE) or by DOE management and operating contractors and other contractors who perform work at DOE-owned or -leased facilities, including management and integration contractors and environmental restoration management contractors (when using funds that will be reimbursed by DOE). Cancels DOE N 110.3.

  5. Apolipoprotein E inhibits osteoclast differentiation via regulation of c-Fos, NFATc1 and NF-?B

    SciTech Connect (OSTI)

    Kim, Woo-Shin; Kim, Hyung Joon; Lee, Zang Hee [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of); Lee, Youngkyun [Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu 700-422 (Korea, Republic of); Kim, Hong-Hee, E-mail: hhbkim@snu.ac.kr [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of)

    2013-02-15

    Apolipoprotein E (ApoE) plays a major role in the transport and metabolism of lipid. Other functions of ApoE include modulation of innate and adaptive immune responses. The expression of ApoE in osteoblasts and its relevance with bone formation have also been reported. However, the effect of ApoE on osteoclasts has not yet been examined. Here, we investigated the role of ApoE in osteoclast differentiation using bone marrow-derived macrophages (BMMs) and RAW264.7 cells. We found a down-regulation of ApoE gene expression during osteoclastic differentiation of those cells. Overexpression of ApoE in BMMs and RAW264.7 cells significantly blocked the induction of c-Fos and nuclear factor of activated T cell c1 (NFATc1), transcription factors critical for expression of osteoclast marker genes, by receptor activator of nuclear factor ?B ligand (RANKL), the osteoclast differentiation factor. ApoE inhibited osteoclast differentiation, as measured by decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells (MNCs). In addition, ApoE reduced the expression of dendritic cell-specific transmembrane protein (DC-STAMP) and ATPase, H{sup +} transporting, lysosomal 38 kDa, V0 subunit d2 (ATP6v0d2), genes involved in cell–cell fusion during osteoclastogenesis. Knock-down of ApoE using a specific siRNA promoted the RANKL-mediated induction of osteoclast differentiation. While ApoE did not affect the activation of ERK, JNK, and p38 MAPK signaling pathways by RANKL, the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were reduced by ApoE overexpression. These findings suggest that ApoE plays an inhibitory role in osteoclast differentiation via the suppression of RANKL-dependent activation of NF-?B and induction of c-Fos and NFATc1. - Highlights: ? Apolipoprotein E (ApoE) significantly inhibited osteoclast differentiation and activation of NF-?B. ? ApoE decreased the induction of osteoclast marker genes such as c-Fos, NFATc1, TRAP, DC-STAMP and Cathepsin K. ? ApoE reduced number of TRAP-positive multinuclear cells. ? Exogenous ApoE inhibits osteoclast formation by reduction of crucial factor of osteoclast differentiation. ? knock-down of ApoE promoted the RANKL-mediated induction of osteoclast differentiation.

  6. Differential Effects of ?-catenin and NF-?B Interplay in the Regulation of Cell Proliferation, Inflammation and Tumorigenesis in Response to Bacterial Infection

    E-Print Network [OSTI]

    Chandrakesan, Parthasarathy; Jakkula, Laxmi Uma Maheswar Rao; Ahmed, Ishfaq; Roy, Badal; Anant, Shrikant; Umar, Shahid

    2013-11-21

    Both ?-catenin and NF-?B have been implicated in our laboratory as candidate factors in driving proliferation in an in vivo model of Citrobacter rodentium (CR)-induced colonic crypt hyper-proliferation and hyperplasia. Herein, we test the hypothesis...

  7. GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF-B ACTIVATION AND NITRIC OXIDE PRODUCTION*

    E-Print Network [OSTI]

    Nicchitta, Chris

    GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF- B signaling and ni- tric oxide production, as well as the MAP kinase p38, JNK, and ERK signaling cascades a marked increase in ERK phosphorylation at protein concentrations as low as 2 g/ml. These results

  8. Energy Management in Microgrids: Algorithms and System

    E-Print Network [OSTI]

    Shi, Wenbo

    2015-01-01

    Energy Management . . . . . . . . . . . . . . . . . . . . .Distributed Energy Management . . . . . . . . . . . . . . .Energy Management . . . . . . . . . . . . . . . . . . . . .

  9. Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-?B-mediated matrix metalloproteinase-9 expression

    SciTech Connect (OSTI)

    Kao, Shang-Jyh [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China) [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); School of Respiratory Therapy, Taipei Medical University, Taipei Taiwan (China); Su, Jen-Liang [Graduate Institute of Cancer Biology, College of Medicine, China Medical University, Taichung, Taiwan (China) [Graduate Institute of Cancer Biology, College of Medicine, China Medical University, Taichung, Taiwan (China); Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan (China); Department of Biotechnology, Asia University, Taichung, Taiwan (China); Chen, Chi-Kuan [Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China)] [Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China); Yu, Ming-Chih; Bai, Kuan-Jen; Chang, Jer-Hua [Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan (China)] [Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan (China); Bien, Mauo-Ying [School of Respiratory Therapy, Taipei Medical University, Taipei Taiwan (China) [School of Respiratory Therapy, Taipei Medical University, Taipei Taiwan (China); Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan (China); Yang, Shun-Fa [Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan (China) [Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan (China); Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan (China); Chien, Ming-Hsien, E-mail: mhchien1976@gmail.com [Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan (China)] [Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan (China)

    2012-05-15

    The induction of matrix metalloproteinase (MMP)-9 is particularly important for the invasiveness of various cancer cells. Osthole, a natural coumarin derivative extracted from traditional Chinese medicines, is known to inhibit the proliferation of a variety of tumor cells, but the effect of osthole on the invasiveness of tumor cells is largely unknown. This study determines whether and by what mechanism osthole inhibits invasion in CL1-5 human lung adenocarcinoma cells. Herein, we found that osthole effectively inhibited the migratory and invasive abilities of CL1-5 cells. A zymographic assay showed that osthole inhibited the proteolytic activity of MMP-9 in CL1-5 cells. Inhibition of migration, invasion, and MMP2 and/or MMP-9 proteolytic activities was also observed in other lung adenocarcinoma cell lines (H1299 and A549). We further found that osthole inhibited MMP-9 expression at the messenger RNA and protein levels. Moreover, a chromatin immunoprecipitation assay showed that osthole inhibited the transcriptional activity of MMP-9 by suppressing the DNA binding activity of nuclear factor (NF)-?B in the MMP-9 promoter. Using reporter assays with point-mutated promoter constructs further confirmed that the inhibitory effect of osthole requires an NF-?B binding site on the MMP-9 promoter. Western blot and immunofluorescence assays demonstrated that osthole inhibited NF-?B activity by inhibiting I?B-? degradation and NF-?B p65 nuclear translocation. In conclusion, we demonstrated that osthole inhibits NF-?B-mediated MMP-9 expression, resulting in suppression of lung cancer cell invasion and migration, and osthole might be a potential agent for preventing the invasion and metastasis of lung cancer. -- Highlights: ? Osthole treatment inhibits lung adenocarcinoma cells migration and invasion. ? Osthole reduces the expression and proteolytic activity of MMP-9. ? Osthole inhibits MMP-9 transcription via suppression of NF-?B binding activity. ? Osthole inhibits I?B? degradation and NF-?B nucleus translocation. ? Osthole suppresses EMT by repressing vimentin and inducing E-cadherin expression.

  10. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

    SciTech Connect (OSTI)

    Verhaak, Roel GW; Hoadley, Katherine A; Purdom, Elizabeth; Wang, Victoria; Qi, Yuan; Wilkerson, Matthew D; Miller, C Ryan; Ding, Li; Golub, Todd; Mesirov, Jill P; Alexe, Gabriele; Lawrence, Michael; O'Kelly, Michael; Tamayo, Pablo; Weir, Barbara A; Gabriel, Stacey; Winckler, Wendy; Gupta, Supriya; Jakkula, Lakshmi; Feiler, Heidi S; Hodgson, J Graeme; James, C David; Sarkaria, Jann N; Brennan, Cameron; Kahn, Ari; Spellman, Paul T; Wilson, Richard K; Speed, Terence P; Gray, Joe W; Meyerson, Matthew; Getz, Gad; Perou, Charles M; Hayes, D Neil; Network, The Cancer Genome Atlas Research

    2009-09-03

    The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.

  11. Simulating QCD at the Physical Point with $N_f=2$ Wilson Twisted Mass Fermions at Maximal Twist

    E-Print Network [OSTI]

    ETM Collaboration; A. Abdel-Rehim; C. Alexandrou; F. Burger; M. Constantinou; P. Dimopoulos; R. Frezzotti; K. Hadjiyiannakou; K. Jansen; C. Kallidonis; B. Kostrzewa; G. Koutsou; M. Mangin-Brinet; M. Petschlies; G. Pientka; G. C. Rossi; C. Urbach; U. Wenger

    2015-07-17

    We present simulations of QCD using Nf=2 dynamical Wilson twisted mass lattice QCD with physical value of the pion mass and at one value of the lattice spacing. Such simulations at ~0.09 fm became possible by adding the clover term to the action. While O(a) improvement is still guaranteed by Wilson twisted mass fermions at maximal twist, the introduction of the clover term reduces cutoff effects related to isospin symmetry breaking. We give results for a set of phenomenologically interesting observables like pseudo-scalar masses and decay constants, quark masses and the anomalous magnetic moments of leptons. We mostly find remarkably good agreement with phenomenology, even though we cannot take the continuum and thermodynamic limits.

  12. Update on a short-distance D^0-meson mixing calculation with $N_f=2+1$ flavors

    E-Print Network [OSTI]

    C. C. Chang; C. Bernard; C. M. Bouchard; A. X. El-Khadra; E. D. Freeland; E. Gámiz; A. S. Kronfeld; J. Laiho; R. S. Van de Water

    2014-12-13

    We present an update on our calculation of the short-distance $D^0$-meson mixing hadronic matrix elements. The analysis is performed on the MILC collaboration's $N_f=2+1$ asqtad configurations. We use asqtad light valence quarks and the Sheikoleslami-Wohlert action with the Fermilab interpretation for the valence charm quark. SU(3), partially quenched, rooted, staggered heavy-meson chiral perturbation theory is used to extrapolate to the chiral-continuum limit. Systematic errors arising from the chiral-continuum extrapolation, heavy-quark discretization, and quark-mass uncertainties are folded into the statistical errors from the chiral-continuum fits with methods of Bayesian inference. A preliminary error budget for all five operators is presented.

  13. Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-{kappa}B pathway, and MMP-9 expression

    SciTech Connect (OSTI)

    Kang, Myoung Hee [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Oh, Sang Cheul [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Lee, Hyun Joo [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kang, Han Na; Kim, Jung Lim [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kim, Jun Suk [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Yoo, Young A., E-mail: ydanbi@korea.ac.kr [Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)

    2011-07-15

    Bone morphogenetic proteins (BMPs) have been implicated in tumorigenesis and metastatic progression in various types of cancer cells, but the role and cellular mechanism in the invasive phenotype of gastric cancer cells is not known. Herein, we determined the roles of phosphoinositide 3-kinase (PI3K)/AKT, extracellular signal-regulated protein kinase (ERK), nuclear factor (NF)-{kappa}B, and matrix metalloproteinase (MMP) expression in BMP-2-mediated metastatic function in gastric cancer. We found that stimulation of BMP-2 in gastric cancer cells enhanced the phosphorylation of AKT and ERK. Accompanying activation of AKT and ERK kinase, BMP-2 also enhanced phosphorylation/degradation of I{kappa}B{alpha} and the nuclear translocation/activation of NF-{kappa}B. Interestingly, blockade of PI3K/AKT and ERK signaling using LY294002 and PD98059, respectively, significantly inhibited BMP-2-induced motility and invasiveness in association with the activation of NF-{kappa}B. Furthermore, BMP-2-induced MMP-9 expression and enzymatic activity was also significantly blocked by treatment with PI3K/AKT, ERK, or NF-{kappa}B inhibitors. Immunohistochemistry staining of 178 gastric tumor biopsies indicated that expression of BMP-2 and MMP-9 had a significant positive correlation with lymph node metastasis and a poor prognosis. These results indicate that the BMP-2 signaling pathway enhances tumor metastasis in gastric cancer by sequential activation of the PI3K/AKT or MAPK pathway followed by the induction of NF-{kappa}B and MMP-9 activity, indicating that BMP-2 has the potential to be a therapeutic molecular target to decrease metastasis.

  14. Nuclear NF-?B Expression Correlates With Outcome Among Patients With Head and Neck Squamous Cell Carcinoma Treated With Primary Chemoradiation Therapy

    SciTech Connect (OSTI)

    Balermpas, Panagiotis [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Michel, Yvonne [Senckenberg Institute of Pathology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Senckenberg Institute of Pathology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Wagenblast, Jens [Department of Otorhinolaryngology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Otorhinolaryngology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Seitz, Oliver [Department of Maxillofacial Surgery, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Maxillofacial Surgery, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Sipek, Florian; Rödel, Franz; Rödel, Claus [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Fokas, Emmanouil, E-mail: emmanouil.fokas@kgu.de [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)

    2013-07-15

    Background: To examine whether nuclear NF-?B expression correlates with outcome in patients with head and neck squamous cell carcinoma (HNSCC) treated with primary chemoradiation therapy (CRT). Methods and Materials: Between 2007 and 2010, 101 patients with locally advanced primary HNSCC were treated with definitive simultaneous CRT. Pretreatment biopsy specimens were analyzed for NF-?B p65 (RelA) nuclear immunoreactivity. A sample was assigned to be positive with more than 5% positive nuclear expression. The predictive relevance of NF-?B and clinicopathologic factors for overall survival (OS), progression-free survival (PFS), local progression-free survival (LPFS), and metastasis-free survival (DMFS) was examined by univariate and multivariate analysis. Results: No significant differences between the groups were observed with regard to age, sex, total radiation dose, fractionation mode, total chemotherapy applied, T stage or grading. Patients with p65 nuclear positive biopsy specimens showed significantly a higher rate of lymph node metastasis (cN2c or cN3 status, P=.034). Within a mean follow-up time of 25 months (range, 2.33-62.96 months) OS, PFS, and DMFS were significantly poorer in the p65 nuclear positive group (P=.008, P=.027, and P=.008, respectively). These correlations remained significant in multivariate analysis. Conclusion: NF-?B/p65 nuclear expression is associated with increased lymphatic and hematogenous tumor dissemination and decreased survival in HNSCC patients treated with primary CRT. Our results may foster further investigation of a predictive relevance of NF-?B/p65 and its role as a suitable target for a molecular-based targeted therapy in HNSCC cancer.

  15. Lecturer, Management Lally School of Management

    E-Print Network [OSTI]

    Salama, Khaled

    Lecturer, Management Lally School of Management Rensselaer Polytechnic Institute The enterprise management and organization area of The Lally School of Management at Rensselaer Polytechnic Institute degree equivalent in management, strategy, organization behavior, or an appropriate related field

  16. project management

    National Nuclear Security Administration (NNSA)

    3%2A en Project Management and Systems Support http:www.nnsa.energy.govaboutusouroperationsapmprojectmanagementandsystemssupport

  17. Position Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1992-06-23

    The order prescribes the policies, responsibilities, and procedures for position management within (DOE). Canceled by DOE N 1321.140. Cancels DOE 3510.1

  18. Inhibition of inflammatory mediators contributes to the anti-inflammatory activity of KYKZL-1 via MAPK and NF-?B pathway

    SciTech Connect (OSTI)

    Xu, Guang-Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Department of Pharmacology, University of Michigan, Ann Arbor (United States); Du, Yi-Fang; Cheng, Jing; Huan, Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Chen, Shi-Cui [Jinhu Food and Drug Administration, Jiangsu (China); Wei, Shao-Hua [College of Chemistry and Materials Science, Nanjing Normal University, Nanjing (China); Gong, Zhu-Nan, E-mail: biopharmacology@126.com [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Cai, Jie; Qiu, Ting; Wu, Hao; Sun, Ting [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Ao, Gui-Zhen [Department of Medicinal Chemistry, School of Pharmacy, Soochow University, Jiangsu (China)

    2013-10-01

    KYKZL-1, a newly synthesized compound with COX/5-LOX dual inhibition, was subjected to the anti-inflammatory activity test focusing on its modulation of inflammatory mediators as well as intracellular MAPK and NF-?B signaling pathways. In acute ear edema model, pretreatment with KYKZL-1 (p.o.) dose-dependently inhibited the xylene-induced ear edema in mice with a higher inhibition than diclofenac. In a three-day TPA-induced inflammation, KYKZL-1 also showed significant anti-inflammatory activity with inhibition ranging between 20% and 64%. In gastric lesion test, KYKZL-1 elicited markedly fewer stomach lesions with a low index of ulcer as compared to diclofenac in rats. In further studies, KYKZL-1 was found to significantly inhibit the production of NO, PGE{sub 2}, LTB{sub 4} in LPS challenged RAW264.7, which is parallel to its attenuation of the expression of iNOS, COX-2, 5-LOX mRNAs or proteins and inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. Taken together, our data indicate that KYKZL-1 comprises dual inhibition of COX and 5-LOX and exerts an obvious anti-inflammatory activity with an enhanced gastric safety profile via simultaneous inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. - Highlights: • KYKZL-1 is designed to exhibit COX/5-LOX dual inhibition. • KYKZL-1 inhibits NO, PGE{sub 2} and LTB{sub 4} and iNOS, COX-2 and 5-LOX mRNAs and MAPKs. • KYKZL-1 inhibits phosphorylation of MAPKs. • KYKZL-1 inactivates NF-?B pathway.

  19. D O M A I NF A L L 2 0 0 4 55555 How a Top Secret Satellite and Fast-Thinking

    E-Print Network [OSTI]

    D O M A I NF A L L 2 0 0 4 55555 How a Top Secret Satellite and Fast-Thinking Navy and Air Force man in the Navy who had worked directly with the top secret Corona Air Force spy satellite, knew what the weather at the Pacific Ocean splashdown site. "When I arrived in Hawaii, I still had my top secret

  20. Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-{kappa}B translocation and ROS production in synoviocytes

    SciTech Connect (OSTI)

    Hu, Fen; Yang, Shuang; Zhao, Dan; Zhu, Shuyan; Wang, Yuxiang; Li, Junying

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Moderate extracellular acidification regulates intracellular Ca{sup 2+} mobilization. Black-Right-Pointing-Pointer Moderate acidification activates NF-{kappa}B nuclear translocation in synoviocytes. Black-Right-Pointing-Pointer Moderate acidification depresses the ROS production induced by capsaicin. Black-Right-Pointing-Pointer Moderate acidification inhibits capsaicin-caused synoviocyte death. -- Abstract: We previously show the expression of transient receptor potential vanilloid 1 (TRPV1) in primary synoviocytes from collagen-induced arthritis (CIA) rats. Capsaicin and lowered extracellular pH from 7.4 to 5.5 induce cell death through TRPV1-mediated Ca{sup 2+} entry and reactive oxygen species (ROS) production. However, under the pathological condition in rheumatoid arthritis, the synovial fluid is acidified to a moderate level (about pH 6.8). In the present study, we examined the effects of pH 6.8 on the TRPV1-mediated cell death. Our finding is different or even opposite from what was observed at pH 5.5. We found that the moderate extracellular acidification (from pH 7.4 to 6.8) inhibited the capsaicin-induced Ca{sup 2+} entry through attenuating the activity of TRPV1. In the mean time, it triggered a phospholipse C (PLC)-related Ca{sup 2+} release from intracellular stores. The nuclear translocation of NF-{kappa}B was found at pH 6.8, and this also depends on PLC activation. Moreover, the capsaicin-evoked massive ROS production and cell death were depressed at pH 6.8, both of which are dependent on the activation of PLC and NF-{kappa}B. Taken together, these results suggested that the moderate extracellular acidification inhibited the capsaicin-induced synoviocyte death through regulating Ca{sup 2+} mobilization, activating NF-{kappa}B nuclear translocation and depressing ROS production.

  1. ROS and NF-{kappa}B are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes

    SciTech Connect (OSTI)

    Ye Shefang Wu Yihui; Hou Zhenqing; Zhang Qiqing

    2009-02-06

    Carbon nanotubes (CNTs) have potential applications in biosensors, tissue engineering, and biomedical devices because of their unique physico-chemical, electronic and mechanical properties. However, there is limited literature data available concerning the biological properties and toxicity of CNTs. This study aimed to assess the toxicity exhibited by multi-walled CNTs (MWCNTs) and to elucidate possible molecular mechanisms underlying the biological effects of MWCNTs in A549 cells. Exposing A549 cells to MWCNTs led to cell death, changes in cell size and complexity, reactive oxygen species (ROS) production, interleukin-8 (IL-8) gene expression and nuclear factor (NF)-{kappa}B activation. Treatment of A549 cells with antioxidants prior to adding MWCNTs decreased ROS production and abrogated expression of IL-8 mRNA. Pretreatment of A549 cells with NF-{kappa}B inhibitors suppressed MWCNTs-induced IL-8 mRNA expression. These results indicate that MWCNTs are able to induce expression of IL-8 in A549 cells, at least in part, mediated by oxidative stress and NF-{kappa}B activation.

  2. Broken Valence Chiral Symmetry and Chiral Polarization of Dirac Spectrum in N$_f$=12 QCD at Small Quark Mass

    E-Print Network [OSTI]

    Andrei Alexandru; Ivan Horváth

    2014-12-04

    The validity of recently proposed equivalence between valence spontaneous chiral symmetry breaking (vSChSB) and chiral polarization of low energy Dirac spectrum (ChP) in SU(3) gauge theory, is examined for the case of twelve mass-degenerate fundamental quark flavors. We find that the vSChSB-ChP correspondence holds for regularized systems studied. Moreover, our results suggest that vSChSB occurs in two qualitatively different circumstances: there is a quark mass $m_c$ such that for $m > m_c$ the mode condensing Dirac spectrum exhibits standard monotonically increasing density, while for $m_{ch} < m < m_c$ the peak around zero separates from the bulk of the spectrum, with density showing a pronounced depletion at intermediate scales. Valence chiral symmetry restoration may occur at yet smaller masses $m < m_{ch}$, but this has not yet been seen by overlap valence probe, leaving the $m_{ch}=0$ possibility open. The latter option could place massless N$_f$=12 theory outside of conformal window. Anomalous behavior of overlap Dirac spectrum for $m_{ch} < m < m_c$ is qualitatively similar to one observed previously in zero and few-flavor theories as an effect of thermal agitation.

  3. Enterprise Risk Management Program

    E-Print Network [OSTI]

    Hayden, Nancy J.

    Enterprise Risk Management Program DRAFT Introduction to Enterprise Risk Management at UVM 1 #12;Enterprise Risk Management Program DRAFT What is Enterprise Risk Management? Enterprise risk management governance, and accountability · Facilitates effective management of the uncertainty and associated risks

  4. Constrained marine resource management

    E-Print Network [OSTI]

    Murray, Jason Hastings

    2007-01-01

    areas as a risk management tool A. Introduction . . . . .1. Effort management without Technologicalwith Technological Progress Under Effort Management F.

  5. Conference Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-01-25

    The Order establishes requirements and responsibilities for managing conferences sponsored or co-sponsored by the Department of Energy, including the National Nuclear Security Administration. Cancels DOE O 110.3. Canceled by DOE N 251.97.

  6. Involvement of a chromatin modifier in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury: Probably an indirect action via the regulation of NF?B/FasL circuitry

    SciTech Connect (OSTI)

    Chen, Shiwei [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China)] [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China); Dong, Yushu [Department of Neurosurgery, 463rd Hospital of PLA, Shenyang 110042 (China)] [Department of Neurosurgery, 463rd Hospital of PLA, Shenyang 110042 (China); Xu, Chun; Jiang, Liming; Chen, Yongjie; Jiang, Cheng [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China)] [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China); Hou, Wugang, E-mail: gangwuhou@163.com [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 (China)] [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 (China); Li, Wei, E-mail: liweipepeyato@163.com [Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xi’an 710032 (China)] [Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xi’an 710032 (China)

    2013-11-01

    Highlights: •MTA1 expression is upregulated in SCs upon MEHP treatment. •Knockdown of MTA1 in SCs impairs the MEHP-induced NF?B signaling activation. •Knockdown of MTA1 inhibits recruitment of NF?B onto FasL promoter in MEHP-treated SCs. -- Abstract: The Fas/FasL signaling pathway, controlled by nuclear factor-?B (NF?B) at the transcriptional level, is critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell (SC) injury, but the exact regulation mechanism remain unknown. Here, we discovered that expression level of Metastasis associated protein 1 (MTA1), a component of the Mi-2/nucleosome remodeling and deacetylase complex, was upregulated in SCs during the early recovery after MEHP exposure. This expression change was in line with the dynamic changes in germ cell apoptosis in response to MEHP treatment. Furthermore, a knockdown of MTA1 by RNAi in SCs was found to impair the MEHP-induced early activation of NF?B pathway and abolish the recruitment of NF?B onto FasL promoter, which consequently diminished the MEHP-triggered FasL induction. Considering that Fas/FasL is a well characterized apoptosis initiating signaling during SCs injury, our results point to a potential “switch on” effect of MTA1, which may govern the activation of NF?B/FasL cascade in MEHP-insulted SCs. Overall, the MTA1/NF?B/FasL circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after SCs injury.

  7. Rosiglitazone attenuates NF-{kappa}B-dependent ICAM-1 and TNF-{alpha} production caused by homocysteine via inhibiting ERK{sub 1/2}/p38MAPK activation

    SciTech Connect (OSTI)

    Bai, Yong-Ping [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Liu, Yu-Hui [Department of Pharmacology, College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006 (China); Chen, Jia [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Song, Tao [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); You, Yu [Department of Digestive Medicine, Xiangya Second Hospital, Central South University, Changsha, Hunan 410078 (China); Tang, Zhen-Yan [Department of Urologic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Li, Yuan-Jian [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); Zhang, Guo-Gang [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China)]. E-mail: xyzgg2006@sina.com

    2007-08-17

    Previous studies demonstrated an important interaction between nuclear factor-kappaB (NF-{kappa}B) activation and homocysteine (Hcy)-induced cytokines expression in endothelial cells and vascular smooth muscle cells. However, the underlying mechanism remains illusive. In this study, we investigated the effects of Hcy on NF-{kappa}B-mediated sICAM-1, TNF-{alpha} production and the possible involvement of ERK{sub 1/2}/p38MAPK pathway. The effects of rosiglitazone intervention were also examined. Our results show that Hcy increased the levels of sICAM-1 and TNF-{alpha} in cultured human umbilical vein endothelial cells (HUVECs) in a time- and concentration-dependent manner. This effect was significantly depressed by rosiglitazone and different inhibitors (PDTC, NF-{kappa}B inhibitor; PD98059, MEK inhibitor; SB203580, p38MAPK specific inhibitor; and staurosporine, PKC inhibitor). Next, we investigated the effect of Hcy on ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B activity in HUVECs. The results show that Hcy activated both ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B-DNA-binding activity. These effects were markedly inhibited by rosiglitazone as well as other inhibitors (SB203580, PD98059, and PDTC). Further, the pretreatment of staurosporine abrogated ERK{sub 1/2}/p38MAPK phosphorylation, suggesting that Hcy-induced ERK{sub 1/2}/p38MAPK activation is associated with PKC activity. Our results provide evidence that Hcy-induced NF-{kappa}B activation was mediated by activation of ERK{sub 1/2}/p38MAPK pathway involving PKC activity. Rosiglitazone reduces the NF-{kappa}B-mediated sICAM-1 and TNF-{alpha} production induced by Hcy via inhibition of ERK{sub 1/2}/p38MAPK pa0011thw.

  8. Time Management Managing Time and Tasks

    E-Print Network [OSTI]

    Kunkle, Tom

    Time Management Managing Time and Tasks What is time management? Time can't be managed ­ but you can manage the amount of time you use each day for fun, work, rest, and time spent with others. Why is time management important? You have responsibilities to yourself, to your family and friends, to your

  9. Palouse Subbasin Management Plan 3. Management Plan

    E-Print Network [OSTI]

    Palouse Subbasin Management Plan 3. Management Plan FINAL DRAFT ~ May 2004 Project Lead: Palouse-Rock Lake Conservation District Trevor Cook, Project Manager PO Box 438 St. John WA 99171 (509) 648;Palouse Subbasin Plan: MANAGEMENT PLAN Management Plan: Page 3 - 1 3. Management Plan 3.1 Background

  10. Managing the Management: CORBAbased Instrumentation of Management Systems

    E-Print Network [OSTI]

    Managing the Management: CORBA­based Instrumentation of Management Systems A. Keller Munich Network Management Team Department of Computer Science, TU MË? unchen Arcisstr. 21, D­80333 Munich, Germany akeller@ieee.org Proceedings of the Sixth IFIP/IEEE International Symposium on Integrated Network Management (IM'99), Boston

  11. Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-?B and MAPK pathways

    SciTech Connect (OSTI)

    Zeng, Ke-Wu [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Li, Jun [Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China); Dong, Xin; Wang, Ying-Hong; Ma, Zhi-Zhong; Jiang, Yong; Jin, Hong-Wei [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Tu, Peng-Fei, E-mail: pengfeitu@vip.163.com [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China)

    2013-11-15

    Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiovascular diseases. Therefore, AR inhibition seems to be a useful strategy for anti-inflammation therapy. In the central nervous system (CNS), microglial over-activation is considered to be a central event in neuroinflammation. However, the effects of AR inhibition in CNS inflammation and its underlying mechanism of action remain unknown. In the present study, we found that FMHM (a naturally derived AR inhibitor from the roots of Polygala tricornis Gagnep.) showed potent anti-neuroinflammatory effects in vivo and in vitro by inhibiting microglial activation and expression of inflammatory mediators. Mechanistic studies showed that FMHM suppressed the activity of AR-dependent phospholipase C/protein kinase C signaling, which further resulted in downstream inactivation of the I?B kinase/I?B/nuclear factor-kappa B (NF-?B) inflammatory pathway. Therefore, AR inhibition-dependent NF-?B inactivation negatively regulated the transcription and expression of various inflammatory genes. AR inhibition by FMHM exerted neuroprotective effects in lipopolysaccharide-induced neuron–microglia co-cultures. These findings suggested that AR is a potential target for neuroinflammation inhibition and that FMHM could be an effective agent for treating or preventing neuroinflammatory diseases. - Highlights: • FMHM is a natural-derived aldose reductase (AR) inhibitor. • FMHM inhibits various neuroinflammatory mediator productions in vitro and in vivo. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent NF-?B pathway. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent MAPK pathway. • FMHM protects neurons against inflammatory injury in microglia-neuron co-cultures.

  12. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NF?B pathways

    SciTech Connect (OSTI)

    Das, Joydeep; Ghosh, Jyotirmoy; Roy, Anandita; Sil, Parames C.

    2012-04-01

    Mangiferin, a xanthone glucoside, is well known to exhibit antioxidant, antiviral, antitumor, anti-inflammatory and gene-regulatory effects. In the present study, we isolated mangiferin from the bark of Mangifera indica and assessed its beneficial role in galactosamine (GAL) induced hepatic pathophysiology. GAL (400 mg/kg body weight) exposed hepatotoxic rats showed elevation in the activities of serum ALP, ALT, levels of triglycerides, total cholesterol, lipid-peroxidation and reduction in the levels of serum total proteins, albumin and cellular GSH. Besides, GAL exposure (5 mM) in hepatocytes induced apoptosis and necrosis, increased ROS and NO production. Signal transduction studies showed that GAL exposure significantly increased the nuclear translocation of NF?B and elevated iNOS protein expression. The same exposure also elevated TNF-?, IFN-?, IL-1?, IL-6, IL-12, IL-18 and decreased IL-10 mRNA expressions. Furthermore, GAL also decreased the protein expression of Nrf2, NADPH:quinine oxidoreductase-1, heme oxygenase-1 and GST?. However, mangiferin administration in GAL intoxicated rats or coincubation of hepatocytes with mangiferin significantly altered all these GAL-induced adverse effects. In conclusion, the hepatoprotective role of mangiferin was due to induction of antioxidant defense via the Nrf2 pathway and reduction of inflammation via NF?B inhibition. Highlights: ?Galactosamine induces hepatocytes death via oxidative and nitrosative stress. ?Mangiferin exerts hepatoprotective effect/antioxidant defense via Nrf2 pathway. ?Mangiferin exerts anti-inflammatory responses by inhibiting NF-?B. ?Mangiferin suppresses galactosamine-induced repression of IL-10 mRNA.

  13. Hadron-Hadron Interactions from $N_f=2+1+1$ Lattice QCD: isospin-2 $\\pi\\pi$ scattering length

    E-Print Network [OSTI]

    Helmes, C; Knippschild, B; Liu, C; Liu, J; Liu, L; Urbach, C; Ueding, M; Wang, Z; Werner, M

    2015-01-01

    We present results for the $I=2$ $\\pi\\pi$ scattering length using $N_f=2+1+1$ twisted mass lattice QCD for three values of the lattice spacing and a range of pion mass values. Due to the use of Laplacian Heaviside smearing our statistical errors are reduced compared to previous lattice studies. A detailed investigation of systematic effects such as discretisation effects, volume effects, and pollution of excited and thermal states is performed. After extrapolation to the physical point using chiral perturbation theory at NLO we obtain $M_\\pi a_0=-0.0442(2)_\\mathrm{stat}(^{+4}_{-0})_\\mathrm{sys}$.

  14. Waste Management Quality Assurance Plan

    E-Print Network [OSTI]

    Waste Management Group

    2006-01-01

    management assessments. Management assessment results mustbe documented. WMG management must take prompt action tolegal advice to Laboratory management, periodically conducts

  15. Management'': Sunderraman

    E-Print Network [OSTI]

    Brass, Stefan

    INFSCI 2710 ``Database Management'': B. Oracle SQL*Plus B­1 Appendix B: Oracle SQL*Plus I have used: Oracle/SQL Tutorial, 1999. http://www.db.cs.ucdavis.edu/teaching/sqltutorial/ . Stefan Brass: Skript zur Vorlesung Informationssysteme (in German), UniversitË? at Hildesheim, 1996/97. . SQL*Plus User's Guide

  16. Risk Management Policy Category: Strategic Management

    E-Print Network [OSTI]

    1 Risk Management Policy Category: Strategic Management 1. PURPOSE To support the University will be encouraged to speak openly and honestly. (iii) Managers will monitor risk and will disclose risks identified's risk appetite. 2.3. Risk management standards 2.3.1 The University's risk management framework

  17. Privacy Management Plan 1 Privacy Management Plan

    E-Print Network [OSTI]

    University of Technology, Sydney

    Privacy Management Plan 1 Privacy Management Plan Abstract The Privacy Management Plan outlines how Impact Assessment Tool (.docm) (staff only) Records Management Vice-Chancellor's Directive Handling Management Plan 2 Legislation Privacy and Personal Information Protection Act 1998 (NSW) (PPIPIA) Health

  18. Environmental Engineering and Management

    E-Print Network [OSTI]

    Mirza, Umar Karim

    2001-01-01

    Review: Environmental Engineering and Management By J.M.H. Power (Eds. ). Environmental Engineering and Management.Conference on Environmental Engineering and Management,

  19. Environmental Management System Plan

    E-Print Network [OSTI]

    Fox, Robert

    2009-01-01

    OIA/OCA/assurance-sys/IA/index.html Management Program, R-3 • Environmental Management System Plan References 30.targets, and Environmental Management Programs 6. Structure

  20. ORISE: Emergency Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Management Emergency Management Effective emergency management relies on thorough integration of preparedness plans at all levels of government. The Oak Ridge Institute for Science...

  1. Presented by FACILITIES MANAGEMENT

    E-Print Network [OSTI]

    Meyers, Steven D.

    Presented by FACILITIES MANAGEMENT TRANSFORMING USF'S TAMPA CAMPUS SUMMER 2011 #12; WELCOME Facili:es Management #12; Facili:es Management #12; NEW CONSTRUCTION Facili

  2. Stargate: Energy Management Techniques

    E-Print Network [OSTI]

    Vijay Raghunathan; Mani Srivastava; Trevor Pering; Roy Want

    2004-01-01

    Stargate: Energy Management Techniques Vijay Raghunathan,Platform specific energy management is crucial for longSolution: System level energy management techniques and

  3. Environmental Management System Plan

    E-Print Network [OSTI]

    Fox, Robert

    2009-01-01

    430.2B mandates an energy management program that considersSTAR® or Federal Energy Management Programs, and USDA-Environmental, Energy, and Transportation Management (

  4. Environmental Management System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Management System Environmental Management System An Environmental Management System is a systematic method for assessing mission activities, determining the environmental impacts...

  5. Environmental Management System Plan

    E-Print Network [OSTI]

    Fox, Robert

    2009-01-01

    Management Program, R-3 • Environmental Management SystemEnvironmental policy 3. Environmental aspects 4. Legal andObjectives, targets, and Environmental Management Programs

  6. NF_Eder_2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines light on771/6/14 Contact: Janet Lambert4 FLCNETL-ORD4NEVIS-NEWS MEDIAmail3

  7. TGF-{beta}1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-{kappa}B/IL-6/MMP-2

    SciTech Connect (OSTI)

    Binker, Marcelo G.; CBRHC Research Center, Buenos Aires ; Binker-Cosen, Andres A.; Gaisano, Herbert Y.; Cosen, Rodica H. de; Cosen-Binker, Laura I.

    2011-02-04

    Research highlights: {yields} Rac1 mediates TGF-{beta}1-induced SW1990 invasion through MMP-2 secretion and activation. {yields} NADPH-generated ROS act downstream of Rac1 in TGF-{beta}1-challenged SW1990 cells. {yields} TGF-{beta}1-stimulated ROS activate NF-{kappa}B in SW1990 cells. {yields} NF{kappa}B-induced IL-6 release is required for secretion and activation of MMP-2 in SW1990 cells. -- Abstract: Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-{beta}1) has been shown to increase both secretion of MMP-2 and invasion by several pancreatic cancer cell types. In the present study, we investigated the signaling pathway involved in TGF-{beta}1-promoted MMP-2 secretion and invasion by human pancreatic cancer cells SW1990. Using specific inhibitors, we found that stimulation of these tumor cells with TGF-{beta}1 induced secretion and activation of the collagenase MMP-2, which was required for TGF-{beta}1-stimulated invasion. Our results also indicate that signaling events involved in TGF-{beta}1-enhanced SW1990 invasiveness comprehend activation of Rac1 followed by generation of reactive oxygen species through nicotinamide adenine dinucleotide phosphate-oxidase, activation of nuclear factor-kappa beta, release of interleukin-6, and secretion and activation of MMP-2.

  8. Managing Critical Management Improvement Initiatives

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-10-01

    Provides requirements and responsibilities for planning, executing and assessing critical management improvement initiatives within DOE. DOE N 251.59, dated 9/27/2004, extends this Notice until 10/01/2005. Archived 11-8-10. Does not cancel other directives.

  9. MUSHROOM WASTE MANAGEMENT PROJECT LIQUID WASTE MANAGEMENT

    E-Print Network [OSTI]

    #12;MUSHROOM WASTE MANAGEMENT PROJECT LIQUID WASTE MANAGEMENT PHASE I: AUDIT OF CURRENT PRACTICE The Mushroom Waste Management Project (MWMP) was initiated by Environment Canada, the BC Ministry of solid and liquid wastes generated at mushroom producing facilities. Environmental guidelines

  10. Stormwater Management 

    E-Print Network [OSTI]

    Jaber, Fouad

    2008-10-23

    ), nitrogen (fertilizer), pesticides, oil and grease, concrete truck washout, and construction chemicals. Who Applies for Permits? Managers should designate an employee to be responsible for applying for the proper construction permits. The USEPA has labeled... of flowing water. When materials impervious to water, such as pavement and concrete, cover the ground or when soils are compacted, runoff increases. Differences between areas with natural ground cover (before urban development) and those with impervious...

  11. Environmental Management

    SciTech Connect (OSTI)

    2014-11-12

    Another key aspect of the NNSS mission is Environmental Management program, which addresses the environmental legacy from historic nuclear weapons related activities while also ensuring the health and safety of present day workers, the public, and the environment as current and future missions are completed. The Area 5 Radioactive Waste Management site receives low-level and mixed low-level waste from some 28 different generators from across the DOE complex in support of the legacy clean-up DOE Environmental Management project. Without this capability, the DOE would not be able to complete the clean up and proper disposition of these wastes. The program includes environmental protection, compliance, and monitoring of the air, water, plants, animals, and cultural resources at the NNSS. Investigation and implementation of appropriate corrective actions to address the contaminated ground water facilities and soils resulting from historic nuclear testing activities, the demolition of abandoned nuclear facilities, as well as installation of ground water wells to identify and monitor the extent of ground water contamination.

  12. Environmental Management

    ScienceCinema (OSTI)

    None

    2015-01-07

    Another key aspect of the NNSS mission is Environmental Management program, which addresses the environmental legacy from historic nuclear weapons related activities while also ensuring the health and safety of present day workers, the public, and the environment as current and future missions are completed. The Area 5 Radioactive Waste Management site receives low-level and mixed low-level waste from some 28 different generators from across the DOE complex in support of the legacy clean-up DOE Environmental Management project. Without this capability, the DOE would not be able to complete the clean up and proper disposition of these wastes. The program includes environmental protection, compliance, and monitoring of the air, water, plants, animals, and cultural resources at the NNSS. Investigation and implementation of appropriate corrective actions to address the contaminated ground water facilities and soils resulting from historic nuclear testing activities, the demolition of abandoned nuclear facilities, as well as installation of ground water wells to identify and monitor the extent of ground water contamination.

  13. Environmental Management Waste Management Facility (EMWMF) at...

    Office of Environmental Management (EM)

    Technical Review Report: Oak Ridge Reservation Review of the Environmental Management Waste Management Facility (EMWMF) at Oak Ridge By Craig H. Benson, PhD, PE; William H....

  14. Best Management Practice #1: Water Management Planning

    Office of Energy Efficiency and Renewable Energy (EERE)

    A successful water management program starts with developing a comprehensive water management plan. This plan should be included within existing facility operating plans.

  15. Environmental and managing

    E-Print Network [OSTI]

    Virginia Tech

    Environmental Education Assessing and managing visitor experiences and impacts Managing natural. A conservation worker Use your communications and management skills in an environmental organization, a government agen- cy, or in cooperative extension to enhance the environmental management. A nature guide

  16. PROJECT MANAGEMENT Professional Organizations

    E-Print Network [OSTI]

    Acton, Scott

    PROJECT MANAGEMENT Professional Organizations: Association of Collegiate Computing Services) Project Management Institute (PMI) Events & Training: UVA Local Support Partners (LSP) program training Project Management Institute webinars Project Management Institute events Scrum Alliance events Learning

  17. PROJECT MANAGEMENT Professional Organizations

    E-Print Network [OSTI]

    Acton, Scott

    PROJECT MANAGEMENT Professional Organizations: Project Management Institute International Association of Project and Program Management (IAPPM) Events & Training: UVa Center for Leadership Excellence classes SkillSoft classes PMO Symposium through PMI Project Management Institute (PMI) webinars American

  18. DEACTIVATION MANAGEMENT

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirley Ann Jackson About UsEnergyofSoftware Engineering Institute | DepartmentAugust8,,MANAGEMENT The

  19. Management Overview

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousandReport)Price (Dollars perManagement Council Emilio Bunel

  20. Management Overview

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousandReport)Price (Dollars perManagement Council Emilio

  1. Risk Management, Mar 2012 Risk Management

    E-Print Network [OSTI]

    Risk Management, Mar 2012 Risk Management Conditions of Volunteer Service (Please send completed form to the Office of Risk Management) riskmanagement@uoregon.edu Fax: 541-346-7008 As a volunteer Tort Claims Act, ORS 30.260-300, and Oregon Department of Administrative Services Risk Management

  2. Risk Management Procedures Category: Strategic Management

    E-Print Network [OSTI]

    1 Risk Management Procedures Category: Strategic Management 1. LEGISLATION/ENTERPRISE AGREEMENT/POLICY SUPPORTED Risk Management Policy Tertiary Education Quality Standards Agency Act 2011 (TEQSA Act 2011) 2 (a) Advise the Vice-Chancellor on the effective management of the University's risk profile

  3. Emergency Management Guide EMERGENCY MANAGEMENT GUIDE

    E-Print Network [OSTI]

    Dahlquist, Kam D.

    Emergency Management Guide #12;EMERGENCY MANAGEMENT GUIDE TABLE OF CONTENTS EXECUTIVE SUMMARY 2 Emergency Management Guide provides guidance to the LMU community to prevent, plan for and respond to events, property, financial condition and reputation of the University. The LMU Emer- gency Management Guide

  4. 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-{kappa}B and ERK/MAPK

    SciTech Connect (OSTI)

    Chen Zhihua [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Na, Hye-Kyung [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Hurh, Yeon-Jin [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Surh, Young-Joon [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of)]. E-mail: surh@plaza.snu.ac.kr

    2005-10-01

    Catechol estrogens, the hydroxylated metabolites of 17{beta}-estradiol (E{sub 2}), have been considered to be implicated in estrogen-induced carcinogenesis. 4-Hydroxyestradiol (4-OHE{sub 2}), an oxidized metabolite of E{sub 2} formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-OHE{sub 2} undergoes 2-electron oxidation to quinone via semiquinone, and during this process, reactive oxygen species (ROS) can be generated to cause DNA damage and cell death. In the present study, 4-OHE{sub 2} was found to elicit cytotoxicity in cultured human mammary epithelial (MCF-10A) cells, which was blocked by the antioxidant trolox. MCF-10A cells treated with 4-OHE{sub 2} exhibited increased intracellular ROS accumulation and 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, and underwent apoptosis as determined by poly(ADP-ribose)polymerase cleavage and disruption of mitochondrial transmembrane potential. The redox-sensitive transcription factor nuclear factor {kappa}B (NF-{kappa}B) was transiently activated by 4-OHE{sub 2} treatment. Cotreatment of MCF-10A cells with the NF-{kappa}B inhibitor, L-1-tosylamido-2-phenylethyl chloromethyl ketone, exacerbated 4-OHE{sub 2}-induced cell death. 4-OHE{sub 2} also caused transient activation of extracellular signal-regulated protein kinases (ERK) involved in transmitting cell survival or death signals. A pharmacological inhibitor of ERK aggravated the 4-OHE{sub 2}-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death.

  5. 8 Management Plan Introduction

    E-Print Network [OSTI]

    312 8 Management Plan Introduction The management plan integrates the vision for the Lower Mid and populations which form the bulk of the management plan is derived from that input. The scope of the management and inventory are designed and may be used to guide restoration and management actions by many parties under

  6. Virginia Commonwealth University Facilities Management

    E-Print Network [OSTI]

    Hammack, Richard

    .3 Solid Waste Management 14 018.4 Pest Management Plan 14 Facilities Management Construction & Design Virginia Commonwealth University Facilities Management Construction & Design Construction Management (804) 6285199 VCU Construction & Inspection Management jghosh

  7. Project Manager's Guide to Managing Impact and Process Evaluation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Project Manager's Guide to Managing Impact and Process Evaluation Studies Project Manager's Guide to Managing Impact and Process Evaluation Studies This report provides a...

  8. DOE Jobs Online (Hiring Manager), Office of Human Capitol Management...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and...

  9. DRAFT Fifteenmile Management Plan 5. Fifteenmile Subbasin Management Plan

    E-Print Network [OSTI]

    DRAFT Fifteenmile Management Plan 5. Fifteenmile Subbasin Management Plan DRAFT May 25 2004 Group 5. FIFTEENMILE SUBBASIN MANAGEMENT PLAN Management Plans

  10. Decision support for disaster management

    E-Print Network [OSTI]

    Rolland, Erik; Patterson, Raymond A.; Ward, Keith; Dodin, Bajis

    2010-01-01

    of the disaster management organizations. Therefore, thishybrid meta-heuristics. Keywords Disaster management . Meta-heuristics . Project management . Scheduling . Decision

  11. Essays on University Technology Management

    E-Print Network [OSTI]

    Drivas, Kyriakos

    2011-01-01

    of university technology management and their implicationson University Technology Management by Kyriakos Drivas Aon University Technology Management by Kyriakos Drivas

  12. Summary - Environmental Management Waste Management Facility...

    Office of Environmental Management (EM)

    Oak Ridge, TN EM Project: EM Waste Management Facility ETR Report Date: February 2008 ETR-11 United States Department of Energy Office of Environmental Management (DOE-EM) External...

  13. Run manager module for CORAL laboratory management

    E-Print Network [OSTI]

    Klann, Jeffrey G

    2004-01-01

    This thesis describes a new module, the Run Manager (RM), for Stanford Nanofabrication Facility's Common Object Representation for Advanced Laboratories (CORAL). CORAL is the lab manager with which MIT's Microsystems ...

  14. BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PL LDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN

    E-Print Network [OSTI]

    Florida, University of

    BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PL LDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN BUILDING A R RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN BUILDIN T PLAN BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEM

  15. Fleet Management | Department of Energy

    Energy Savers [EERE]

    Property Fleet Management Fleet Management Fleet management includes commercial and agency owned motor vehicles such as cars, vans, trucks, and buses. Fleet (vehicle) management...

  16. Enterprise Risk Management Program

    E-Print Network [OSTI]

    Hayden, Nancy J.

    Enterprise Risk Management Program Guide to Risk Assessment & Response August 16, 2012 #12; i ...........26 List of Figures Figure 1: The Risk Management Process.......................................................................................................12 #12; 1 Overview The risk management process--of identifying, analyzing, evaluating

  17. Classroom Management Study through

    E-Print Network [OSTI]

    Douches, David S.

    Classroom Management Study through Michigan State Extension What is the Incredible Years Teacher Classroom Management (IYTCM) Program? This program is an evidence-based interven4on focused on improving teachers' skills in using classroom management

  18. Managing Web Data Managing Web Data

    E-Print Network [OSTI]

    Davulcu, Hasan

    Managing Web Data Dan Suciu AT&T Labs Managing Web Data Sigmod, 1999 Dan Suciu AT&T Labs 1 #12;How the Web is Today HTML documents all intended for human consumption many are generated automatically by applications Managing Web Data Sigmod, 1999 Dan Suciu AT&T Labs 2 #12;Paradigm Shift on the Web applications

  19. Supply Management Specialist

    Broader source: Energy.gov [DOE]

    This position is located in the Logistics Management organization (NSL), Supply Chain Services (NS), Chief Administrative Office (N). NSL manages the warehousing of materials; the investment...

  20. Contract/Project Management

    Office of Environmental Management (EM)

    Contract and Project Management Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2011 Target FY 2011 Actual & Forecast FY 2011...

  1. Contract/Project Management

    Office of Environmental Management (EM)

    and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2011 Target FY 2011 Forecast FY 2011 Pre- &...

  2. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Contract and Project Management Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2010 Target FY 2010 Actual FY 2010 Pre- &...

  3. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    Contract and Project Management Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2010 Target FY 2010 Forecast FY 2010 Pre- &...

  4. Contract/Project Management

    Energy Savers [EERE]

    and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Performance Metric FY 2012 Target FY 2012 Forecast FY 2012 Pre- & Post-CAP...

  5. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Performance Metric FY 2012 Target FY 2012 Final FY 2012 Pre- & Post-CAP Final...

  6. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    2 nd Quarter Overall Contract and Project Management Performance Metrics and Targets ContractProject Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1....

  7. Contract/Project Management

    Office of Environmental Management (EM)

    1 st Quarter Overall Contract and Project Management Performance Metrics and Targets ContractProject Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1....

  8. Contract/Project Management

    Office of Environmental Management (EM)

    3 rd Quarter Overall Contract and Project Management Performance Metrics and Targets ContractProject Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1....

  9. Management of Nuclear Materials

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-08-17

    To establish requirements for the lifecycle management of DOE owned and/or managed accountable nuclear materials. Cancels DOE O 5660.1B.

  10. Digital Data Management Plans

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Digital Data Management Plans Digital Data Management Plans Investigating the field of high energy physics through experiments that strengthen our fundamental understanding of...

  11. Contract/Project Management

    Energy Savers [EERE]

    Third Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Performance Metric FY 2012 Target FY 2012 Forecast...

  12. Risk Management Policy 1 Risk Management Policy (December, 2014)

    E-Print Network [OSTI]

    Wapstra, Erik

    Risk Management Policy 1 Risk Management Policy (December, 2014) Risk Management Policy Responsible Governance Level Principle No. 2 - Risk Management Responsible Organisational Unit Audit & Risk CONTENTS 1 ........................................................................................................2 3.1 Effective Risk Management

  13. PERFORMANCE MANAGEMENT TIP SHEET Performance Management for New Employees

    E-Print Network [OSTI]

    PERFORMANCE MANAGEMENT TIP SHEET Performance Management for New Employees NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION UNITED STATES DEPARTMENT OF COMMERCE Workforce Management Office Ready to Perform Management at NOAA Performance Management is the process used to communicate expectations, evaluate employee

  14. Business, management and finance

    E-Print Network [OSTI]

    Sussex, University of

    Business, management and finance Essentials Taught degrees Masters in Business Administration (MBA and Finance MSc in Managing Innovation and Projects MSc in Technology and Innovation Management Research 156-157 MBA You will have at least three years' management experience in a professional work

  15. 6 Management Plan Introduction

    E-Print Network [OSTI]

    147 6 Management Plan Introduction The management plan integrates the vision for the White Salmon for restoration of fish and wildlife habitat and populations which form the bulk of the management plan is derived from that input. The scope of the management plan is somewhat narrower than the scope of the assessment

  16. Chemical Management Contacts

    Broader source: Energy.gov [DOE]

    Contacts for additional information on Chemical Management and brief description on Energy Facility Contractors Group

  17. Benchmarking Corporate Energy Management 

    E-Print Network [OSTI]

    Norland, D. L.

    2001-01-01

    CORPORATE ENERGY MANAGEMENT Dr. Douglas L. Norland Director of Research and Industrial Programs Alliance to Save Energy Washington, DC ABSTRACT There is growing interest among energy managers in finding out how their company's energy management... procedures and perfonnance compare to that of other companies. Energy management involves everything from setting goals and targets to implementing best maintenance practices. This paper, however, discusses benchmarking energy management practices...

  18. Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-{kappa}B pathway: New lessons from endotoxin and ribotoxic deoxynivalenol

    SciTech Connect (OSTI)

    Moon, Yuseok [Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan, 602-739 (Korea, Republic of)], E-mail: moon@pusan.ac.kr; Yang, Hyun; Park, Seung-Hwan [Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan, 602-739 (Korea, Republic of)

    2008-08-15

    Mucosal epithelium senses external toxic insults and transmits the danger signals into the epithelial cells in order to activate a broad range of inflammatory responses. However, pre-exposure to the commensal endotoxins can induce inflammatory tolerance and maintain the homeostasis without excessive immune responses. We recently reported that ribotoxin deoxynivalenol (DON) and its derivatives elicited the pro-inflammatory response as the mucosal insults in human epithelial cells. Taking the knowledge into consideration, we tested the hypothesis that endotoxin pre-exposure can attenuate ribotoxin-induced epithelial interleukin-8 (IL-8) production via a tolerance mechanism. Pre-exposure to endotoxin repressed IL-8 release and its gene expression. However, inflammatory tolerance was not mediated by the attenuated NF-{kappa}B activation which has been generally recognized as the major mediator of LPS-mediated toll-like receptor (TLR) signaling pathway. Instead, pre-exposure to endotoxin was observed to trigger the delayed induction of peroxisome proliferator-activated receptor gamma (PPAR-{gamma}) which contributed to the diminished IL-8 production in the human epithelial cells. Moreover, endogenous PPAR-{gamma} agonist suppressed toxicant-mediated interleukin-8 production and IL-8 mRNA stability. Taken together, endotoxin induced hypo-production of pro-inflammatory cytokine IL-8 in the human epithelial cells, which was associated with the delayed activation of PPAR-{gamma} expression by pre-existing endotoxin.

  19. Energy Management in Microgrids: Algorithms and System

    E-Print Network [OSTI]

    Shi, Wenbo

    2015-01-01

    Energy Management . . . . . . . . . . . . . . . . . . . . .116 Energy Scheduling . . . . . .Distributed Energy Management . . . . . . . . . . . . . . .

  20. The Waste Management Quality Assurance Implementing Management Plan (QAIMP)

    E-Print Network [OSTI]

    Albert editor, R.

    2009-01-01

    III I II QUALITY ASSURANCE IMPLEMENTING MANAGEMENT PLAN I III SECTION 1 - MANAGEMENT Criterion 1 - Program II II WM-AND SAFETY DIVISION Waste Management Quality Assurance

  1. The Waste Management Quality Assurance Implementing Management Plan (QAIMP)

    E-Print Network [OSTI]

    Albert editor, R.

    2009-01-01

    AND SAFETY DIVISION Waste Management Quality AssuranceII I RECORD I WM-QAIMP Waste Management Quality Assurancefor hazardous waste management that have leadership

  2. Fusing Integration Test Management with Change Management

    E-Print Network [OSTI]

    Perry, Dewayne E.

    - 1 - Infuse: Fusing Integration Test Management with Change Management Gail E. Kaiser* Dewayne E, NJ 07974 Murray Hill, NJ 07974 Infuse is an experimental software development environment focusing the change set into the baseline. We have previously described how Infuse enforces static consistency at each

  3. Research Data Management - Data Management Plans

    E-Print Network [OSTI]

    Collins, Anna

    2012-01-01

    -Graduate Teaching Materials for Research Data Management Adapted by Anna Collins (2012) from modules created by Lindsay Lloyd-Smith (2011) for post-graduate training in Archaeology It makes use of training materials produced by the UK Data Archive on Managing...

  4. Energy Management in Microgrids: Algorithms and System

    E-Print Network [OSTI]

    Shi, Wenbo

    2015-01-01

    Optimal Energy Management in Microgrids . . . . . . . . . .Management in Microgrids . . . . . . . . . . . . . . . .Hatziargyriou, and A. Dimeas, “Microgrids management,” IEEE

  5. Management of Nuclear Materials

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-08-17

    To establish requirements for the lifecycle management of DOE owned and/or managed accountable nuclear materials. Admin Chg 1 dated 4-10-2014, supersedes DOE O 410.2.

  6. Risk Management Guide

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-01-18

    This Guide provides non-mandatory risk management approaches for implementing the requirements of DOE O 413.3B, Program and Project Management for the Acquisition of Capital Assets. Supersedes DOE G 413.3-7.

  7. Enabling better water management

    E-Print Network [OSTI]

    Greenslade, Diana

    CASE STUDY Enabling better water management Seasonal Streamflow Forecast Service influencing water decisions Water management decisions made with confidence Using the Bureau's streamflow forecasting, ACTEW Water confidently removed temporary water restrictions after the millennium drought. Millennium drought

  8. ENVIRONMENTAL MANAGEMENT Environmental Policy

    E-Print Network [OSTI]

    Haase, Markus

    ENVIRONMENTAL MANAGEMENT Environmental Policy February 2013 The University of Leeds is responsible to reflect best environmental practice, implement an environmental management system to pursue sustainability and continuous improvement and seek innovative ways of meeting environmental objectives. These include: To meet

  9. Information Technology Project Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-03

    The Order provides program and project management direction for the acquisition and management of IT projects, investments, and initiatives. Cancels DOE G 200.1-1. Admin Chg 1 approved 1-16-2013.

  10. Management Associate I

    Broader source: Energy.gov [DOE]

    A successful candidate in this position will serve as an analyst and advisor to an organization's manager and other managers within the organization within BPA. The position serves as a point of...

  11. Management Excellence by Sandra Waisley

    Office of Environmental Management (EM)

    Roadmap Goal 7 Achieve Excellence in Management and Leadership, www.em.doe.gov safety performance cleanup closure E M Environmental Management 1 Achieve Excellence in Management...

  12. Energy manager design for microgrids

    E-Print Network [OSTI]

    Firestone, Ryan; Marnay, Chris

    2005-01-01

    Energy Manager Design for Microgrids Hillier, F. , and G.Energy Manager Design for Microgrids Appendix A: Smart*DER:Manager Design for Microgrids Prepared for the California

  13. Waste Management Quality Assurance Plan

    E-Print Network [OSTI]

    Waste Management Group

    2006-01-01

    LBNL/PUB-5352, Revision 6 Waste Management QualityAssurance Plan Waste Management Group Environment, HealthRev. 6 WM QA Plan Waste Management Quality Assurance Plan

  14. Waste Management Quality Assurance Plan

    E-Print Network [OSTI]

    Waste Management Group

    2006-01-01

    Waste Management group organization chart. Revised to updatecurrent practices. New organization chart, roles, andManagement Group organization chart. EH&S Waste Management

  15. Wildlife Management Areas (Florida)

    Broader source: Energy.gov [DOE]

    Certain sites in Florida are designated as wildlife management areas, and construction and development is heavily restricted in these areas.

  16. Conservation and drought management 

    E-Print Network [OSTI]

    Finch, Calvin

    2012-01-01

    Column by Dr. Calvin Finch, Water Conservation and Technology Center director Conservation and Drought Management WAT E R CONSERVATION & TECHNOLOGY CENTER Securing Our Water Future Water conservation and drought management are related..., but they are not the same. Water conservation is a long-term e?ort to reduce the amount of water it takes to manufacture goods, manage households and care for landscapes. Drought management is water-use rules initiated to deal with reduced water supply or increased...

  17. Toward Strategic Watershed Management

    E-Print Network [OSTI]

    Toward Strategic Watershed Management: Lessons from the Boone River Watershed Program Evaluation Resources Ecology and Management June, 2013 #12;2 Introduction Water quality is a growing problem throughout management on private and working lands. The Iowa Soybean Association (ISA) began work in the Boone River

  18. NJIT STRATEGIC ENROLLMENT MANAGEMENT

    E-Print Network [OSTI]

    NJIT STRATEGIC ENROLLMENT MANAGEMENT PLAN: FIRST STAGE YEARS 2015 TO 2020 #12;1 NJIT STRATEGIC ENROLLMENT MANAGEMENT PLAN: FIRST STAGE YEARS 2015 TO 2020 SEM AT NJIT 2015-2020 2015-2020 "Strategic addressing all aspects of the institutions mission. " - A Practical Guide to Strategic Enrollment Management

  19. Risk Management Strategy Introduction

    E-Print Network [OSTI]

    Edinburgh, University of

    Risk Management Strategy Introduction 1. The risk of adverse consequences is inherent in all activity. Dynamic enterprise will inevitably create new risks. Risk management is about ensuring that all significant relevant risks are understood and prioritised as part of normal management

  20. February 2002 RISK MANAGEMENT

    E-Print Network [OSTI]

    February 2002 RISK MANAGEMENT GUIDANCE FOR INFORMATION TECHNOLOGY SYSTEMS By Joan S. Hash, Computer is the ability to iden tify and protect critical information assets. A sound risk management pro gram-30, Risk Management Guide For Information Technology Systems, by Gary Stoneburner, Alice Goguen, and Alexis

  1. Business, management and finance

    E-Print Network [OSTI]

    Sussex, University of

    Business, management and finance Essentials Taught degrees Masters in Business Administration (MBA) MSc in Banking and Finance MSc in Corporate and Financial Risk Management MSc in Financial Mathematics in International Accounting and Corporate Governance MSc in International Finance MSc in International Management

  2. Financial Management Oversight

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-08-31

    The Order defines requirements for effective financial management and adherence to DOE and applicable external financial management requirements and sets forth standards for ensuring the integrity and responsiveness of financial management and the accuracy and reliability of DOEs financial statements. Supersedes DOE O 2200.13.

  3. HAZARDOUS WASTE MANAGEMENT REFERENCE

    E-Print Network [OSTI]

    Winfree, Erik

    HAZARDOUS WASTE MANAGEMENT REFERENCE GUIDE Prepared by Environment, Health and Safety Office@caltech.edu http://safety.caltech.edu #12;Hazardous Waste Management Reference Guide Page 2 of 36 TABLE OF CONTENTS Satellite Accumulation Area 9 Waste Accumulation Facility 10 HAZARDOUS WASTE CONTAINER MANAGEMENT Labeling

  4. MAINTENANCE MANAGEMENT PROFESSIONAL (MMP)

    E-Print Network [OSTI]

    Saskatchewan, University of

    MAINTENANCE MANAGEMENT PROFESSIONAL (MMP) CERTIFICATE PROGRAM & Distance Education Ron and Jane for Continuing & Distance Education Module 1--Maintenance Management Skills and Techniques latest developments and trendsModule 1 introduces the basic concepts of physical asset management and the in effective

  5. Manage Your Time 

    E-Print Network [OSTI]

    White, Lynn

    2000-06-27

    People view time in different ways, but we all could do a better job of managing our time. This publication explains three different time management tools: the 24-hour time log and chart; a self-assessment of thinking styles and time management...

  6. University of Manchester Researchers Into Management Researchers into Management

    E-Print Network [OSTI]

    Higham, Nicholas J.

    University of Manchester ­ Researchers Into Management ! ! ! ! Researchers into Management ! ! Institute of Leadership and Management Candidate Guide and Unit Requirements ! !1 Version Updated December 2013 ! Institute of Leadership & Management Candidate Guide & Unit Requirements for Level 5 Award

  7. DOE - Office of Legacy Management -- Fernald Environmental Management...

    Office of Legacy Management (LM)

    Fernald Environmental Management Project - 027 FUSRAP Considered Sites Site: Fernald Environmental Management Project (027) Designated Name: Alternate Name: Location: Evaluation...

  8. Radioactive Waste Management Basis

    SciTech Connect (OSTI)

    Perkins, B K

    2009-06-03

    The purpose of this Radioactive Waste Management Basis is to describe the systematic approach for planning, executing, and evaluating the management of radioactive waste at LLNL. The implementation of this document will ensure that waste management activities at LLNL are conducted in compliance with the requirements of DOE Order 435.1, Radioactive Waste Management, and the Implementation Guide for DOE Manual 435.1-1, Radioactive Waste Management Manual. Technical justification is provided where methods for meeting the requirements of DOE Order 435.1 deviate from the DOE Manual 435.1-1 and Implementation Guide.

  9. Christopher J. Martin BUSINESS MANAGEMENT

    E-Print Network [OSTI]

    Pittendrigh, Barry

    Christopher J. Martin DIRECTOR BUSINESS MANAGEMENT Joanna M. Hutchins ADMINISTRATIVE ASSISTANT BUSINESS MANAGEMENT BUSINESS PROCESS MANAGEMENTCLUSTER MANAGERS & DIRECTORS OF FINANCIAL AFFAIRSFREEHAFER OPERATIONS #12;Christopher J. Martin DIRECTOR BUSINESS MANAGEMENT *Andrew J. Bean PHARMACY *Kristi L. Mickle

  10. A Manager's Approach to Energy Cost Management 

    E-Print Network [OSTI]

    Spencer, R. J.

    1985-01-01

    A major responsibility of management is the control and containment of operating costs. Energy costs are a major portion of the industrial budget. GM has developed a 3 phase approach to energy conservation. Phase I -Administrative Controls...

  11. Managing a Process Safety Management inspection

    SciTech Connect (OSTI)

    Mulvey, N.P. [AcuTech Consulting, Inc., Princeton, NJ (United States)

    1995-12-31

    The Occupational Safety and Health Administration (OSHA) Process Safety Management (PSM) regulations (29 CFR {section} 1910.119) have been in effect for almost three years. State level risk management programs, in New Jersey, California, and Delaware have been in effect for over six years. More recently, Nevada and Louisiana have enacted process safety management programs. These regulations have had a significant impact on all phases of plant operations, including preliminary design, construction, startup, and operations. Through proper planning and the commitment of resources, many facilities are beginning to realize the benefits of well developed PSM programs. This paper will discuss in greater detail some of these benefits, and in particular, the subject of governmental inspections of facilities for process safety management programs.

  12. Energy Management Working Group: Accelerating Energy Management 

    E-Print Network [OSTI]

    Scheihing, P.

    2014-01-01

    of energy management systems (EnMS) in the industrial and commercial building sectors. EnMS can help organizations potentially conserve 10%-40% of their energy use by institutionalizing the policies, procedures and tools to systematically track, analyze...

  13. Army Regulation 2550 Information Management: Records

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Army Regulation 25­50 Information Management: Records Management Preparing and Managing Information Management: Records Management Preparing and Managing Correspondence *Army Regulation 25. This regulation on the prepa- ration and management of Army corre- spondence has been revised. This revision

  14. Strategies for Successful Energy Management

    Broader source: Energy.gov [DOE]

    This presentation, given through the DOE's Technical Assitance Program (TAP), provides information on energy management for the portfolio manager initiative

  15. Master of Science in Engineering and Technology Management Engineering Management Concentration Management of Technology Concentration

    E-Print Network [OSTI]

    Selmic, Sandra

    Master of Science in Engineering and Technology Management Engineering Management Concentration Management of Technology Concentration Core Courses 21 Core Courses 6 FINC 577 Finance and Accounting for Non Management INEN 505 Manufacturing and Operations Analysis INEN 507 Engineering Administration Quantitative

  16. Dietary turmeric modulates DMBA-induced p21{sup ras}, MAP kinases and AP-1/NF-{kappa}B pathway to alter cellular responses during hamster buccal pouch carcinogenesis

    SciTech Connect (OSTI)

    Garg, Rachana; Ingle, Arvind; Maru, Girish

    2008-11-01

    The chemopreventive efficacy of turmeric has been established in experimental systems. However, its mechanism(s) of action are not fully elucidated in vivo. The present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis at 2, 4, 6, 10 and 12 weeks. Dietary turmeric (1%) led to decrease in DMBA-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modulatory effects on oncogene products and various cellular responses during HBP tumorigenesis. DMBA-induced expression of ras oncogene product, p21 and downstream target, the mitogen-activated protein kinases were significantly decreased by turmeric during HBP carcinogenesis. Turmeric also diminished the DMBA-induced mRNA expression of proto-oncogenes (c-jun, c-fos) and NF-{kappa}B, leading to decreased protein levels and in further attenuation of DMBA-induced AP-1/NF-{kappa}B DNA-binding in the buccal pouch nuclear extracts. Besides, buccal pouch of hamsters receiving turmeric diet showed significant alterations in DMBA-induced effects: (a) decrease in cell proliferation (diminished PCNA and Bcl2 expression), (b) enhanced apoptosis (increased expression of Bax, caspase-3 and apoptotic index), (c) decrease in inflammation (levels of Cox-2, the downstream target of AP-1/NF-{kappa}B, and PGE2) and (d) aberrant expression of differentiation markers, the cytokeratins (1, 5, 8, and 18). Together, the protective effects of dietary turmeric converge on augmenting apoptosis of the initiated cells and decreasing cell proliferation in DMBA-treated animals, which in turn, is reflected in decreased tumor burden, multiplicity and enhanced latency period. Some of these biomarkers are likely to be helpful in monitoring clinical trials and evaluating drug effect measurements.

  17. Activation of ROS/NF-{kappa}B and Ca{sup 2+}/CaM kinase II are necessary for VCAM-1 induction in IL-1{beta}-treated human tracheal smooth muscle cells

    SciTech Connect (OSTI)

    Luo, S.-F. [Department of Internal Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Chang, C.-C.; Lee, I-T. [Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Lee, C.-W. [Department of Nursing, Division of Basic Medical Sciences, Chang Gung Institute of Technology, Chia-Yi, Taiwan (China); Lin, W.-N. [Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Lin, C.-C. [Department of Anesthetics, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Yang, C.-M. [Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China)], E-mail: chuenmao@mail.cgu.edu.tw

    2009-05-15

    Histone acetylation regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) plays a critical role in the expression of inflammatory genes, such as vascular cell adhesion molecule-1 (VCAM-1). Oxidative processes have been shown to induce VCAM-1 expression. Here, we investigated the mechanisms underlying IL-1{beta}-induced VCAM-1 expression in human tracheal smooth muscle cells (HTSMCs). Our results showed that IL-1{beta} enhanced HTSMCs-monocyte adhesion through up-regulation of VCAM-1, which was inhibited by pretreatment with selective inhibitors of PKC{alpha} (Goe6976), c-Src (PP1), NADPH oxidase [diphenylene iodonium (DPI) and apocynin (APO)], intracellular calcium chelator (BAPTA/AM), PI-PLC (U73122), CaM (calmidazolium chloride), CaM kinase II (KN62), p300 (garcinol), NF-{kappa}B (Bay11-7082), HDAC (trichostatin A), and ROS scavenger [N-acetyl-L-cysteine (NAC)] or transfection with siRNAs of MyD88, PKC{alpha}, Src, p47{sup phox}, p300, and HDAC4. Moreover, IL-1{beta} stimulated NF-{kappa}B and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKC{alpha}/c-Src/ROS and PI-PLC/Ca{sup 2+}/CaM pathways, respectively. Activation of NF-{kappa}B and CaMKII may eventually lead to the acetylation of histone residues and phosphorylation of histone deacetylases. These findings suggested that IL-1{beta} induced VCAM-1 expression via these multiple signaling pathways in HTSMCs. Blockade of these pathways may reduce monocyte adhesion via VCAM-1 suppression and attenuation of the inflammatory responses in airway diseases.

  18. Nutrient Management TrainingNutrient Management Training for Technical Service Providersfor Technical Service Providers

    E-Print Network [OSTI]

    Nutrient Management TrainingNutrient Management Training for Technical Service Providersfor Management Planning Technical Guidance.Management Planning Technical Guidance. Manure and Wastewater Handling Nutrient ManagementNutrient Management ­­ Record KeepingRecord Keeping ­­ Feed ManagementFeed Management

  19. Weed Management Costs, Weed Best Management Practices, and The Roundup Ready Weed Management Program

    E-Print Network [OSTI]

    Mitchell, Paul D.

    Weed Management Costs, Weed Best Management Practices, and The Roundup Ready® Weed Management-commercial purposes by any means, provide that this copyright notice appears on all such copies. #12;1 Weed Management Costs, Weed Best Management Practices, and The Roundup Ready® Weed Management Program T.M. Hurley

  20. Managing Increased Charging Demand

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Managing Increased Charging Demand Carrie Giles ICF International, Supporting the Workplace Charging Challenge Workplace Charging Challenge Do you already own an EV? Are you...

  1. Efficient Water Use & Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Water Use Goal 4: Efficient Water Use & Management Aware of the arid climate of northern New Mexico, water reduction and conservation remains a primary concern at LANL. Energy...

  2. Hazardous Waste Management (Indiana)

    Broader source: Energy.gov [DOE]

    The state supports the implementation of source reduction, recycling, and other alternative solid waste management practices over incineration and land disposal. The Department of Environmental...

  3. Solid Waste Management (Indiana)

    Broader source: Energy.gov [DOE]

    The state supports the implementation of source reduction, recycling, and other alternative solid waste management practices over incineration and land disposal. The Indiana Department of...

  4. Radioactive Waste Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1984-02-06

    To establish policies and guidelines by which the Department of Energy (DOE) manages tis radioactive waste, waste byproducts, and radioactively contaminated surplus facilities.

  5. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2005-11-02

    The Order establishes policy and assigns roles and responsibilities for the Department of Energy (DOE) Emergency Management System. Supersedes DOE O 151.1B.

  6. Enterprise Risk Management Framework

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Framework The Enterprise Risk Management (ERM) framework includes four steps: identify the risks, determine the probability and impact of each one, identify controls that are...

  7. Parallel integrated thermal management

    DOE Patents [OSTI]

    Bennion, Kevin; Thornton, Matthew

    2014-08-19

    Embodiments discussed herein are directed to managing the heat content of two vehicle subsystems through a single coolant loop having parallel branches for each subsystem.

  8. Logistics Management Specialist

    Broader source: Energy.gov [DOE]

    The Deputy Assistant Secretary for the Office of Petroleum Reserves (OPR) manages the Strategic Petroleum Reserve (SPR) and is responsible for establishing policies, goals, and priorities for the...

  9. Chemical Industry Corrosion Management

    SciTech Connect (OSTI)

    2003-02-01

    Improved Corrosion Management Could Provide Significant Cost and Energy Savings for the Chemical Industry. In the chemical industry, corrosion is often responsible for significant shutdown and maintenance costs.

  10. Energy, Data Management, Reporting

    Broader source: Energy.gov (indexed) [DOE]

    Electric Sustainability Services 2014 4 - - How are you currently managing your energy data? Is your energy data collected manually, and stored in a spreadsheet? Is...

  11. Industrial Property Management Specialist

    Broader source: Energy.gov [DOE]

    A successful candidate in this position will administer the property management program and establish policies, regulations and procedures. Verify that sound internal processes and good business...

  12. Information Technology Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2013-11-21

    This revised Order is needed to clarify the roles and responsibilities, policies, and procedures for effectively managing IT investments to ensure mission success.

  13. Acquisition Career Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-05-14

    The order sets forth requirements and responsibilities for the Department of Energy (DOE) Acquisition Career Management Program. Supersedes DOE O 361.1B.

  14. Change Control Management Guide

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-29

    The Guide provides a suggested approach and uniform guidance for managing project and contract changes through applying the requirements of DOE O 413.3B. No cancellation.

  15. Records Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-02-03

    The Order sets forth requirements and responsibilities for implementing and maintaining a cost-effective records management program throughout the Department of Energy.

  16. Records Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-26

    The Order sets forth requirements and responsibilities for establishing and maintaining a program for the efficient and economical management of records and information assets.

  17. Dreissenid Mussel Prevention, Management...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Management, Research, Coordination, and Outreach for the Columbia River Basin A Roadmap to Make Strategic Investments in Federal Columbia River Power System and Technology...

  18. Dreissenid Mussel Prevention, Management, ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Management, Research, Coordination, and Outreach for the Columbia River Basin A Roadmap to Make Strategic Investments in Federal Columbia River Power System and Technology...

  19. Management Control Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2002-04-18

    To establish requirements and responsibilities for the Department of Energy Management Control Program. Cancels DOE O 413.1. Canceled by DOE O 413.1B.

  20. International Commitments Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-11-18

    This Order establishes a process to manage the Department's International Commitments under the administrative direction of the Office of Policy and International Affairs. No cancellation.

  1. Energy Management Systems 

    E-Print Network [OSTI]

    Ferland, K.

    2007-01-01

    This presentation will address results from a pilot project with 10 chemical plants on energy management systems and the development of an energy efficiency plant certification program....

  2. Advisory Committee Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-10-22

    The Manual provides detailed DOE requirements, responsibilities, processes, and procedures for the establishment, operation, and management of advisory committees. Supersedes DOE M 510.1-1.

  3. Site Office Manager, Princeton

    Broader source: Energy.gov [DOE]

    A successful candidate in this position will serve as the Princeton Site Office (PSO) Manager by providing overall executive leadership to the PSO.

  4. Financial Management Committee

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    will present actual revenue and REP expense running under budget. For BPA management reports, Gross Sales and Purchase Power are shown separated from the power bookout...

  5. Financial Management Committee

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    present actual revenue and REP expense running under rate case estimates. For BPA management reports, Gross Sales and Purchase Power are shown separated from the power bookout...

  6. Management's Discussion & Analysis Profile

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and...

  7. Management's Discussion & Analysis Profile

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in conformity with generally accepted accounting principles (GAAP) requires management to make estimates and assumptions that affect the reported amounts of assets and...

  8. Project Management Practices

    Broader source: Energy.gov (indexed) [DOE]

    Version) See Figure 3-3. 19. Administrative Controls 1. Provisions relating to organization and management, procedures, recordkeeping, assessment, and reporting necessary to...

  9. Constrained marine resource management

    E-Print Network [OSTI]

    Murray, Jason Hastings

    2007-01-01

    III Marine protected areas as a risk management tool A.Fishery Populations and Marine Ecosystmes,” Fisheries, 1999,11–25. Neubert, Michael G. , “Marine reserves and optimal

  10. Grants Management Specialist

    Broader source: Energy.gov [DOE]

    The Office of Science manages fundamental research programs in basic energy sciences, biological and environmental sciences, and computational science. In addition, the Office of Science is the...

  11. Page 1 of 2 Risk Management March 2012 Risk Management

    E-Print Network [OSTI]

    Page 1 of 2 Risk Management March 2012 Risk Management Supervisor's Vehicle Incident Report (Complete all sections of this form and return within 24 hours of incident to the Office of Risk Management Risk Management March 2012 Risk Management Unsafe Conditions or Actions (describe all contributing

  12. Evolution and Evaluation of the Active Management Area Management Plans

    E-Print Network [OSTI]

    Fay, Noah

    of the Fourth Management Plans. This evaluation provides a foundation for change in the approach and contentEvolution and Evaluation of the Active Management Area Management Plans FINAL January 2008 Sharon B and Evaluation of the Active Management Area Management Plans Table of Contents Executive Summary i Introduction

  13. HIERARCHICAL MANAGEMENT OF BATTLEFIELD NETWORKS WITH THE SHAMAN MANAGEMENT SYSTEM

    E-Print Network [OSTI]

    Sethi, Adarshpal

    HIERARCHICAL MANAGEMENT OF BATTLEFIELD NETWORKS WITH THE SHAMAN MANAGEMENT SYSTEM Adarshpal S Architecture for MANagement) is a novel management framework developed at the University of Delaware as a part of the research in network management sponsored by the ATIRP Consortium. SHAMAN extends the traditional flat SNMP

  14. Certificate in Arts Management The Certificate in Arts Management

    E-Print Network [OSTI]

    Certificate in Arts Management The Certificate in Arts Management is designed for those students interested in pursuing future careers in the management of arts organizations. It is also suitable for majors.uwindsor.ca/arts/certificate Training includes courses in marketing, management, fund-raising, publicity, board and volunteer management

  15. The REMOTE SENSlNf

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal Gas &SCE-SessionsSouth DakotaRobbins and700, 1. .&. ' , c 1afr -.:2yL: a,;. -:-1 / .'

  16. Energy Management Webinar Series

    Broader source: Energy.gov [DOE]

    Boost your knowledge on how to implement an energy management system through this four-part webinar series from the Superior Energy Performance program. Each webinar introduces various elements of the ISO 50001 energy management standard—based on the Plan-Do-Check-Act approach—and the associated steps of DOE's eGuide for ISO 50001 software tool.

  17. Risk Management Guide

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-09-16

    This Guide provides a framework for identifying and managing key technical, schedule, and cost risks through applying the requirements of DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, dated 7-28-06. Canceled by DOE G 413.3-7A, dated 1-12-11. Does not cancel other directives.

  18. Comprehensive Irrigation Management 

    E-Print Network [OSTI]

    Cook, K.

    2011-01-01

    ? Disconnect with conservation investments & sustainable water savings ? High turnover rates among property managers and landscape contractors ? Economic pressures on operating expense to maintain system integrity Result: Devalued service with zero... consumption ? Soil characteristics ? Environmental conditions ? Landscape cultural practices ? Irrigation system performance Comprehensive Irrigation Management ? Restoration of antiquated irrigation systems ? Implementation of new control...

  19. Management of severe accidents

    SciTech Connect (OSTI)

    Jankowski, M.W.

    1988-01-01

    The definition and the multidimensionality aspects of accident management have been reviewed. The suggested elements in the development of a programme for severe accident management have been identified and discussed. The strategies concentrate on the two tiered approaches. Operative management utilizes the plant's equipment and operators capabilities. The recovery management concentrates on preserving the containment, or delaying its failure, inhibiting the release, and on strategies once there has been a release. The inspiration for this paper was an excellent overview report on perspectives on managing severe accidents in commercial nuclear power plants and extending plant operating procedures into the severe accident regime; and by the most recent publication of the International Nuclear Safety Advisory Group (INSAG) considering the question of risk reduction and source term reduction through accident prevention, management and mitigation. The latter document concludes that active development of accident management measures by plant personnel can lead to very large reductions in source terms and risk, and goes further in considering and formulating the key issue: The most fruitful path to follow in reducing risk even further is through the planning of accident management.

  20. Information Collection Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-10-11

    This Order sets forth DOE requirements and responsibilities for implementing the information collection management provisions of the Paperwork Reduction Act of 1995 and the Office of Management and Budgets implementing regulation Controlling Paperwork Burdens on the Public, as contained in 5 CFR 1320. No cancellation.

  1. COURSE OUTLINE Management 3313

    E-Print Network [OSTI]

    COURSE OUTLINE Management 3313 Developing Leadership Skills Online Syllabus Faculty: Andrew L Classroom): http://oc.okstate.edu Administrative contact: CEPD Distance Learning Office, 108 Gundersen, cepd, the focus will be on self- management and interpersonal concepts as opposed to organizational leadership

  2. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-11-01

    To establish policy and to assign and describe roles and responsibilities for the Department of Energy (DOE) Emergency Management System. The Emergency Management System provides the framework for development, coordination, control, and direction of all emergency planning, preparedness, readiness assurance, response, and recovery actions. Canceled by DOE O 151.1B. Cancels DOE O 151.1.

  3. EMERGENCY MANAGEMENT Effective Date

    E-Print Network [OSTI]

    Fernandez, Eduardo

    SUBJECT: EMERGENCY MANAGEMENT Effective Date: 4-7-14 Policy Number: 1.14 Supersedes: Policy 4 assets and ensure continued operations during and after all manner of emergencies, whether natural or man- made, by implementing appropriate emergency management policies, plans, and procedures designed

  4. Responsive classroom management 

    E-Print Network [OSTI]

    Stough, Laura

    2008-01-01

    stream_source_info Responsive classroom management.pdf.txt stream_content_type text/plain stream_size 9 Content-Encoding ISO-8859-1 stream_name Responsive classroom management.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  5. Salinity Management Desalination Technology

    E-Print Network [OSTI]

    Scott, Christopher

    Salinity Management and Desalination Technology for Brackish Water Resources in the Arid West.S. Bureau of Reclamation August, 2008 #12;Salinity Management and Desalination Technology for Brackish Water a practical roadmap forward for achieving sustainable, viable desalination of inland, moderate salinity waters

  6. Better Buildings Neighborhood Program Grant Recipient Management...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Grant Recipient Management Handbook Better Buildings Neighborhood Program Grant Recipient Management Handbook Better Buildings Neighborhood Program Grant Recipient Management...

  7. Energy Management in Microgrids: Algorithms and System

    E-Print Network [OSTI]

    Shi, Wenbo

    2015-01-01

    Energy Management System . . . . . . . . .An energy management system. . . . . . . . . . . . . .D. Saez, “A microgrid energy management system based on the

  8. CONTACTS FOR INFORMATION MANAGEMENT: Forms, Privacy & Records...

    Energy Savers [EERE]

    CONTACTS FOR INFORMATION MANAGEMENT: Forms, Privacy & Records CONTACTS FOR INFORMATION MANAGEMENT: Forms, Privacy & Records Maria Levesque, Director Records & Privacy Management...

  9. Environmental Management Advisory Board Subcommittees | Department...

    Energy Savers [EERE]

    Communication & Engagement EMAB Environmental Management Advisory Board Subcommittees Environmental Management Advisory Board Subcommittees ACQUISITION AND PROJECT MANAGEMENT...

  10. Project Management Career Development Program | Department of...

    Office of Environmental Management (EM)

    You are here Home Operational Management Certifications and Professional Development Project Management Career Development Program Project Management Career Development...

  11. Line Management Perspective: Office of Environmental Management (EM)

    Broader source: Energy.gov [DOE]

    Slide Presentation by Matthew Moury, Deputy Assistant Secretary for Safety, Security and Quality Programs, Office of Environmental Management. EFCOG Integrated Safety Management Work Planning and Control.

  12. Management Not Available 12 MANAGEMENT OF RADIOACTIVE AND NON...

    Office of Scientific and Technical Information (OSTI)

    87 Oak Ridge model conference: Proceedings: Volume I, Part 3, Waste Management Not Available 12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE WASTES FROM NUCLEAR FACILITIES; 11...

  13. Identity and Access Management: Access Management Survey 1 Access Management Survey Questions

    E-Print Network [OSTI]

    Maroncelli, Mark

    Identity and Access Management: Access Management Survey 1 Access Management Survey Questions The Identity and Access Management (IAM) Technical Architect Group (TAG) was formed by Kevin Morooney, the vice assistance with defining the requirements for Access Management, as outlined in Strategic Recommendations 4

  14. Risk Management Process Overview | Department of Energy

    Energy Savers [EERE]

    Risk Management Process Overview Risk Management Process Overview figure depicting three tier risk management process The cybersecurity risk management process explained in the...

  15. Copenhagen Waste Management and Incineration

    E-Print Network [OSTI]

    Columbia University

    Copenhagen Waste Management and Incineration Florence, April 24 2009 Julie B. Svendsen 24 20092 Presentation · General introduction to Copenhagen Waste Management System · National incentives · Waste Management plan 2012 · Incineration plants #12;Florence, April 24 20093 Copenhagen Waste

  16. Collection Management Policy Mission Statement

    E-Print Network [OSTI]

    Abrahams, I. David

    Collection Management Policy Mission Statement: To provide an efficient and effective service care, document supply, stock management, and logistical planning and relegation of the Library Management Policy ..................................3 2. Acquisition of Content

  17. October 2006 LOG MANAGEMENT: USING

    E-Print Network [OSTI]

    to Computer Security Log Management NIST's Information Technology Laboratory recently issued SpecialOctober 2006 LOG MANAGEMENT: USING COMPUTER AND NETWORK RECORDS TO IMPROVE INFORMATION SECURITY LOG MANAGEMENT: USING COMPUTER AND NETWORK RECORDS TO IMPROVE INFORMATION SECURITY Shirley Radack, Editor

  18. Nuclear materials management overview

    SciTech Connect (OSTI)

    DiGiallonardo, D.A. )

    1988-01-01

    The true goal of Nuclear Materials MANAGEMENT (NMM) is the strategical and economical management of all nuclear materials. Nuclear Materials Management's role involves near-term and long-term planning, reporting, forecasting, and reviewing of inventories. This function is administrative in nature. it is a growing area in need of future definition, direction, and development. Improvements are required in program structure, the way residues and wastes are determined, how ''what is and what if'' questions are handled, and in overall decision-making methods.

  19. Nuclear materials management overview

    SciTech Connect (OSTI)

    DiGiallonardo, D.A.

    1988-01-01

    The true goal of Nuclear Materials Management (NMM) is the strategical and economical management of all nuclear materials. Nuclear Materials Management's role involves near-term and long-term planning, reporting, forecasting, and reviewing of inventories. This function is administrative in nature. It is a growing area in need of future definition, direction, and development. Improvements are required in program structure, the way residues and wastes are determined, how /open quotes/What is and what if/close quotes/ questions are handled, and in overall decision-making methods. 2 refs.

  20. Radioactive Waste Management Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    This Manual further describes the requirements and establishes specific responsibilities for implementing DOE O 435.1, Radioactive Waste Management, for the management of DOE high-level waste, transuranic waste, low-level waste, and the radioactive component of mixed waste. The purpose of the Manual is to catalog those procedural requirements and existing practices that ensure that all DOE elements and contractors continue to manage DOE's radioactive waste in a manner that is protective of worker and public health and safety, and the environment. Does not cancel other directives.

  1. Secure Transportation Management

    SciTech Connect (OSTI)

    Gibbs, P. W.

    2014-10-15

    Secure Transport Management Course (STMC) course provides managers with information related to procedures and equipment used to successfully transport special nuclear material. This workshop outlines these procedures and reinforces the information presented with the aid of numerous practical examples. The course focuses on understanding the regulatory framework for secure transportation of special nuclear materials, identifying the insider and outsider threat(s) to secure transportation, organization of a secure transportation unit, management and supervision of secure transportation units, equipment and facilities required, training and qualification needed.

  2. Management Principles | Department of Energy

    Energy Savers [EERE]

    Management Principles Management Principles managementprinciples-S-2Poneman---2009-12-02.pdf More Documents & Publications Diversity and Inclusion Strategic Plan 2012 - 2015...

  3. Research Data Management: Tools & Services

    E-Print Network [OSTI]

    Tsang, Daniel C

    2013-01-01

    Research Data Management Tools & Services Daniel C.Data Librarian, UCI Libraries Research Data Management Manyand provide stewardship for research data generated by

  4. Office of Information Management

    Broader source: Energy.gov [DOE]

    The Office of Information Management provides a broad range of information technology services in support of the Associate Under Secretary for the Office of Environment, Health, Safety and Security (AU).

  5. Construction work process management 

    E-Print Network [OSTI]

    Soares, Jorge Barbosa

    1994-01-01

    for organizationand project-level work processes. Data to support the analysis were collected through a mailed questionnaire sent to construction executives and managers who were asked to provide information on organizational and project work processes, respectively....

  6. Strategic Energy Management

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy (DOE) SEE Action Network and Weatherization and Intergovernmental Program Technical Assistance Program sponsored this webinar about strategic management in the public sector on November 7, 2012.

  7. Brush Management Methods 

    E-Print Network [OSTI]

    Welch, Tommy G.

    2000-07-14

    . Brush plants such as mesquite may be useful for wood furniture, firewood and charcoal briquets. Brush has both positive and negative charac- teristics. Thus, brush should be managed to meet the established ranch objectives. Brush control methods are used...

  8. Managing Soybean Insects 

    E-Print Network [OSTI]

    Gouge, Dawn H.; Knutson, Allen E.; Cronholm, Gregory B.; Patrick, Carl D.; Way, M. O.

    1999-07-29

    , or if the field is very large, sample more areas to increase 3 Managing Soybean Insects Dawn H. Gouge, Michael O. Way, Allen Knutson, Greg Cronholm and Carl Patrick* *Assistant Professor and Extension Entomologist; Associate Professor, Texas Agricultural...

  9. Keloids: Pathophysiology and management

    E-Print Network [OSTI]

    Robles, David T; Moore, Erin; Draznin, Michelle; Berg, Daniel

    2007-01-01

    low- or high-dose rate brachytherapy [ 52 ]. Post-excisionalhigh dose rate brachytherapy (Ir-192) in the management ofkeloids by high-dose-rate brachytherapy: A seven-year study.

  10. Stage Gate Management Guide

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 nd Edition. 1993, New York:Addison-Wesley Publishing Co. 2 Eidt, C.M., jr. and R.W. Cohen, 'Reinventing' Industrial Basic Research. Research Technology Management, 1997: p....

  11. Transportation Management Workshop: Proceedings

    SciTech Connect (OSTI)

    Not Available

    1993-10-01

    This report is a compilation of discussions presented at the Transportation Management Workshop held in Gaithersburg, Maryland. Topics include waste packaging, personnel training, robotics, transportation routing, certification, containers, and waste classification.

  12. Lawn Water Management 

    E-Print Network [OSTI]

    McAfee, James

    2006-06-26

    Water is a limited resource in Texas. This booklet explains how homeowners can establish a water management program for a home lawn that both maintains a healthy sod and also conserves water. The publication discusses soil types, grass varieties...

  13. Hazardous Waste Management (Delaware)

    Broader source: Energy.gov [DOE]

    The act authorizes the Delaware Department of Natural Resources and Environment Control (DNREC) to regulate hazardous waste and create a program to manage sources of hazardous waste. The act...

  14. Solid Waste Management (Kansas)

    Broader source: Energy.gov [DOE]

    This act aims to establish and maintain a cooperative state and local program of planning and technical and financial assistance for comprehensive solid waste management. No person shall construct,...

  15. Management of Nuclear Materials

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1994-05-26

    To establish requirements and procedures for the management of nuclear materials within the Department of Energy (DOE). Cancels DOE 5660.1A. Canceled by DOE O 410.2.

  16. managing the stockpile

    National Nuclear Security Administration (NNSA)

    managed by the National Nuclear Security Administration within the U. S. Department of Energy.

    OST is responsible for the safe and secure transport in the contiguous United...

  17. risk management annual report

    E-Print Network [OSTI]

    Frantz, Kyle J.

    ____________________________________________________________________ 2 The ERM Process______________________________________________________________________ 28 The ERM Process in 2014 and Beyond and mitigating the risks that threaten its mission, the Office of Enterprise Risk Management (ERM) was tasked

  18. Corporate Energy Management Process 

    E-Print Network [OSTI]

    Geiger, T.

    2013-01-01

    Guideline 2000 Geismar Cogeneration ? AOG Fuel Utilization 2001 Freeport Cogeneration Project 2002 Portsmouth Site Energy Team 2003 Freeport ISBL Energy Audits 2004 Energy Management Group (EM) 2004 Geismar Flare Best Practice 2005 Site Energy...

  19. OPERATIONS MANAGEMENT Spring 2008

    E-Print Network [OSTI]

    Almor, Amit

    performance, and various programs (TQM, Reengineering, Lean, Six-Sigma) that can be used for analyzing management in market launches, promotions, or auditing assignments; Six-Sigma in accounts receivables process

  20. Strategic Energy Management

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy (DOE) See Action Network and Weatherization and Intergovernmental Program Technical Assistance Program sponsored this webinar about strategic management in the public sector on November 7, 2012.

  1. Project Management Lessons Learned

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-08-05

    The guide supports DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, and aids the federal project directors and integrated project teams in the execution of projects.

  2. Headquarters Personal Property Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-10-25

    To establish procedures for managing Government personal property owned or leased by the Department of Energy and in the custody of DOE Headquarters employees, including those in the National Nuclear Security Administration. Cancels DOE HQ O 580.1A

  3. Information Technology Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-12-23

    The Order identifies the objectives, components, and responsibilities for implementing processes to ensure the effective management of information and information systems within the Department. Supersedes DOE O 200.1.

  4. "Managing Department Climate Change"

    E-Print Network [OSTI]

    Sheridan, Jennifer

    "Managing Department Climate Change" #12;Presenters · Ronda Callister Professor, Department Department Climate? · Assesment is essential for determining strategies for initiating change · In a research climate · Each panelist will describe an intervention designed to improve department climate ­ Ronda

  5. Facilities Management Services Policy

    E-Print Network [OSTI]

    , central heating and chilled water plants, buildings HVAC, plumbing and electrical and emergency back/exterior finishes (e.g., signage, paint, floor coverings) x Distribution and Mail Services x Fleet Management x

  6. Financial Management Committee

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to the COUs is reflected through a reduction in the Gross Sales amount. For BPA management reports, Gross Sales and Purchase Power are shown separated from the power bookout...

  7. Financial Management Committee

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    is reflected through a reduction in the Gross Sales amount. FY 2012 FY 2011 For BPA management reports, Gross Sales and Purchase Power are shown separated from the power bookout...

  8. Implementing Motor Management 

    E-Print Network [OSTI]

    Colip, R. L.

    2002-01-01

    PRESIDENT-SALES, BALDOR ELECTRlC COMPANY, FORT SMITH, ARKANSAS IMPLEMENTING MOTOR MANAGEMENT ABSTRACT Electric motors account for sixty five percent of industrial energy consumed today. There are many opportunities to conserve electricity by using more...

  9. Human Resource Management Delegation

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-06-28

    The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

  10. Island Wide Management Corporation

    Office of Legacy Management (LM)

    9 1986 Island Wide Management Corporation 3000 Marcus Avenue Lake Success, New York 11042 Dear Sir or Madam: I am sending you this letter and the enclosed information as you have...

  11. Configuration Change Management

    E-Print Network [OSTI]

    Yoder, Nathaniel

    2012-05-11

    shown that if a company does not continue to innovate, whether it is products or services, it will not be able to remain successful. This philosophy is extremely important with design engineering companies. If managed correctly, change can be a...

  12. Radioactive Waste Management Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    This Manual further describes the requirements and establishes specific responsibilities for implementing DOE O 435.1, Radioactive Waste Management, for the management of DOE high-level waste, transuranic waste, low-level waste, and the radioactive component of mixed waste. Change 1 dated 6/19/01 removes the requirement that Headquarters is to be notified and the Office of Environment, Safety and Health consulted for exemptions for use of non-DOE treatment facilities. Certified 1-9-07.

  13. The Watershed Management Approach 

    E-Print Network [OSTI]

    Persyn, Russell A.; Griffin, Molly; Williams, Amy T.; Wolfe, Clint

    2008-08-11

    coordinated environmental management framework that focuses public and private efforts on a watershed?s highest- priority problems. In the past, such an approach was used more commonly in polluted watersheds or those with limited water supplies, but it also... network helps Texans meet their water needs. However, Texas surface water quality varies because of both natural processes and hu- man activities. The state of Texas also monitors and manages the Gulf of Mexico. Planning Determine the watershed planning...

  14. Lithium battery management system

    DOE Patents [OSTI]

    Dougherty, Thomas J. (Waukesha, WI)

    2012-05-08

    Provided is a system for managing a lithium battery system having a plurality of cells. The battery system comprises a variable-resistance element electrically connected to a cell and located proximate a portion of the cell; and a device for determining, utilizing the variable-resistance element, whether the temperature of the cell has exceeded a predetermined threshold. A method of managing the temperature of a lithium battery system is also included.

  15. TWRS safety management plan

    SciTech Connect (OSTI)

    Popielarczyk, R.S., Westinghouse Hanford

    1996-08-01

    The Tank Waste Remediation System (TWRS) Safety Management Program Plan for development, implementation and maintenance of the tank farm authorization basis is described. The plan includes activities and procedures for: (a) Updating the current Interim Safety Basis, (b) Development,implementation and maintenance of a Basis for Interim Operations, (c) Development, implementation and maintenance of the Final Safety Analyses Report, (d) Development and implementation of a TWRS information Management System for monitoring the authorization basis.

  16. Poisonous Plant Management

    E-Print Network [OSTI]

    McGinty, Allan

    1985-01-01

    range specialist, The Texas A&M University System . 2 DIAGNOSING POISONOOS PLANT PROBLEMS Accurate diagnosis of poisonous plant problems can be extremely difficult. Many cases of livestock poisoning by plants have been improperly diagnosed... Agricultural Extension Service ~-P~,IJ& H~iN!/ P~,IJ&--------------- poisonous Plant ___ Management_ ..... Texas Agricultural Extension Service. The Texas A&M University System. College Station, Texas POISONO(]S PLANT MANAGEMENT Allan McGinty* Poisonous...

  17. Change Management within Project Management: An Integrated Structured

    E-Print Network [OSTI]

    Lano, Kevin Charles

    Change Management within Project Management: An Integrated Structured Business Process Approach from a current state to a desired future state. The success of change and project management can is usually only 8% to 15% of the overall project effort (Gottesdiener, 2001). #12;Generic Change Management

  18. Annex 2 Risk Management Guidance and Template SPO Project Management

    E-Print Network [OSTI]

    1 Annex 2 ­ Risk Management Guidance and Template SPO Project Management Guidance on Risk Management Introduction Risk is any action or event that affects a project's ability to achieve its on cost, schedule and technical performance. However, with appropriate procedures, risks can be managed

  19. Mountain Caribou in Managed Forests: Recommendations for Managers

    E-Print Network [OSTI]

    Northern British Columbia, University of

    by the program. Financial support for the production of the second edition of Mountain Caribou in managed forestsMountain Caribou in Managed Forests: Recommendations for Managers Second Edition Susan K. Stevenson, Lands and Parks. #12;iv ACKNOWLEDGEMENTS The first edition of this report, Mountain Caribou in managed

  20. Workforce Management Office (WFMO) Functional Statements WORKFORCE MANAGEMENT OFFICE

    E-Print Network [OSTI]

    May 2014 Workforce Management Office (WFMO) ­ Functional Statements WORKFORCE MANAGEMENT OFFICE The Workforce Management Office (WFMO) is the servicing Human Resource Organization for NOAA and is the principal contact point with the Department of Commerce (DOC) Office of Human Resources Management. WFMO

  1. Faculty Search Announcement Strategic Management

    E-Print Network [OSTI]

    Frantz, Kyle J.

    Faculty Search Announcement Strategic Management Department of Managerial Sciences Robinson College and nominations for multiple tenure track faculty positions at multiple ranks in the area of Strategic Management and teaching interests that represent the different facets of Management including Strategic Management

  2. Risk Management Policy and Procedures

    E-Print Network [OSTI]

    Paxton, Anthony T.

    Risk Management Policy and Procedures #12;Risk Management Policy and Procedures Queen's University Belfast Updated January 2014 1. PURPOSE OF THIS DOCUMENT 1.1 This Risk Management Policy (the policy explains the University's underlying approach to risk management, documents the roles and responsibilities

  3. SUPPLY CHAIN MANAGER CHICAGO, IL

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    or an MBA with emphasis on operations management. Additional training that includes SIX SIGMA, LEAN, CPIM

  4. Service management solutions White paper

    E-Print Network [OSTI]

    an end-to-end service perspective. · Service management platform is built on IBM Tivoli Change to help align operations with business context and enable customers to manage change. Tivoli CCMDBService management solutions White paper Netcool + Tivoli: delivering service management innovation

  5. December 2010 FACILITIES & PROPERTY MANAGEMENT

    E-Print Network [OSTI]

    change with carbon management being the key issue for many organisations. The HE sector must play itsDecember 2010 FACILITIES & PROPERTY MANAGEMENT CARBON MANAGEMENT AND SUSTAINABILITY ACTIVITIES REPORT 2009/10 #12;Contents Page · Introduction 1 · Carbon and Energy Management 3 · Waste and Recycling

  6. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT ANNUAL REPORT January 2008 OFFICE OF UNIVERSITY RISK MANAGEMENT CP-320 714-278-7346 #12;2006 ­ 2007 Risk Management Annual Report Page 2 I. Executive Summary A. Program Cost One method to assess the effectiveness of the University's risk management

  7. Eighth Annual Risk Management Conference

    E-Print Network [OSTI]

    Chaudhuri, Sanjay

    Eighth Annual Risk Management Conference Risk Management Amidst Global Rebalancing 10 ­ 11 July 2014, Singapore The Risk Management Institute (RMI) at the National University of Singapore invites submissions for its 8th annual conference on risk management in Singapore on 10 and 11 July 2014. We

  8. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT ANNUAL REPORT November 2006 OFFICE OF UNIVERSITY RISK MANAGEMENT LH-806C 714-278-7346 #12;2005 ­ 2006 Risk Management Annual Report Page 2 I. Executive Summary A. Program Cost One method to assess the effectiveness of the University's risk management

  9. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT ANNUAL REPORT November 2005 OFFICE OF UNIVERSITY RISK MANAGEMENT LH-806C 714-278-7346 #12;2004 ­ 2005 Risk Management Annual Report Page 2 I. Introduction The Office of University Risk Management provides resources, advice and training that allow

  10. Information Security Office Risk Management

    E-Print Network [OSTI]

    Alpay, S. Pamir

    Information Security Office Risk Management Exception Template #12;Risk Management Exception or Approved) 6/01/2013 CISO Jason Pufahl, CISO Approved 6/01/2013 RMAC Risk Management Advisory Council Reviewed #12;Risk Management Exception Template 2 | P a g e Please check one of the following: Requester

  11. Management Systems Engineering Spring 2013

    E-Print Network [OSTI]

    Sobek II, Durward K.

    ) orientation, and be focused on the modern management paradigm surrounding lean manufacturing and related

  12. By Peter Sandborn Strategic Management

    E-Print Network [OSTI]

    Sandborn, Peter

    By Peter Sandborn Strategic Management of DMSMS in Systems DSP JOURNAL April/June 200824 #12;dsp and management support. However, the majority of the existing offerings focus on reactive and, to a lesser degree, proactive management of DMSMS issues associated with electronic parts. Effective long-term management

  13. Management of ancient wood pasture

    E-Print Network [OSTI]

    Guidance Management of ancient wood pasture Summary Ancient wood pasture is recognised. This guidance note provides an introduction to the restoration and management of ancient wood pastures in Scotland. It is aimed at land managers, their advisers and agency staff involved in land management

  14. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 1999 prepared by: Data Management Group Joint Program APPENDIX A: DATA REQUESTS ..................................... 11 #12;Data Management Group 1999 Annual Report Page 1 of 14 INTRODUCTION The Data Management Group is a research project located at the Joint

  15. Energy Management Issued: June 2010

    E-Print Network [OSTI]

    Energy Management Policy Issued: June 2010 Revised: Responsible Administrative Unit: Finance.0 BACKGROUND AND PURPOSE The Engineering and Energy Management division of the Department of Facilities Management at the Colorado School of Mines ("Mines" or "the school") has developed an Energy Management

  16. Project Management Plan Chinese Food

    E-Print Network [OSTI]

    Igusa, Kiyoshi

    impact of this project? · Data management: How do we collect, preserve and sort all of the files? Which special equipment, facilities needed or wanted? According to http://project-management-knowledge.com/ weProject Management Plan Chinese Food According to NSF, the basic elements of a project management

  17. Emergency Management Concepts, Existing Guidance, and Changes

    Broader source: Energy.gov [DOE]

    Presenter: David Freshwater, Emergency Management Specialist, Office of Emergency Management, National Nuclear Security Administration

  18. Best Practices in Industrial Data Management

    Broader source: Energy.gov (indexed) [DOE]

    or otherwise restricted information. Industrial Data Management What is energy data management? Monitoring Recording Analyzing Reporting ...

  19. Understanding and managing corporate agency problems

    E-Print Network [OSTI]

    Vojtech, Cindy M.

    2011-01-01

    Preceding Management Buyout Offers,” Journal of Accountingofferings, or management buyouts (Teoh, Wong and Rao, 1998b;

  20. Automating Personalized Battery Management on Smartphones

    E-Print Network [OSTI]

    Falaki, Mohamamd Hossein

    2012-01-01

    3 Automating Battery Management . . . . . . .122 Battery Goal Setting UI . . . . . . . . . . . . . . .Power and Battery Management . . . . . . . . . . . . . . .

  1. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-{kappa}B translocation

    SciTech Connect (OSTI)

    Jawan, Bruno [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Kao, Y.-H. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Goto, Shigeru [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Surgery, Iwao Hospital, 3059-1 Kawakami, Yufuin, Oita 879-5102 (Japan); Pan, M.-C. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Lin, Y.-C.; Hsu, L.-W.; Nakano, Toshiaki; Lai, C.-Y.; Sun, C.-K.; Cheng, Y.-F. [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Tai, M.-H. [Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Department of Medical Research and Education, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan (China)] (and others)

    2008-06-15

    Propofol (PPF), a widely used intravenous anesthetic for induction and maintenance of anesthesia during surgeries, was found to possess suppressive effect on host immunity. This study aimed at investigating whether PPF plays a modulatory role in the lipopolysaccharide (LPS)-induced inflammatory cytokine expression in a cell line of rat hepatocytes. Morphological observation and viability assay showed that PPF exhibits no cytotoxicity at concentrations up to 300 {mu}M after 48 h incubation. Pretreatment with 100 {mu}M PPF for 24 h prior to LPS stimulation was performed to investigate the modulatory effect on LPS-induced inflammatory gene production. The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-{alpha}, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression. Western blotting analysis showed that PPF pretreatment potentiated the LPS-induced TLR-4 downregulation. Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes. In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and I{kappa}B{alpha}, as well as the nuclear translocation of NF-{kappa}B primed by LPS. Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-{kappa}B nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway. In conclusion, PPF as an anesthetic may clinically benefit those patients who are vulnerable to sepsis by alleviating sepsis-related inflammatory response in livers.

  2. Personnel / Human Resource Management MGTK 302 Online

    E-Print Network [OSTI]

    Diestel, Geoff

    competencies: Strategic Human Resource Management: Knowledge of strategic management concepts (strategyPersonnel / Human Resource Management MGTK 302 Online Fall 2014 YOUR INSTRUCTOR Name: Ms. Amanda of human resource management; relationship between personnel management and organizations' emerging role

  3. Certified records manager exam

    SciTech Connect (OSTI)

    Not Available

    1990-01-01

    The Institute of Certified Records Managers (ICRM) is a non-profit, certifying organization of professional records managers and administrators. ICRM members are experienced in information requirements, records and information systems, and the related office systems and technologies. All members have met certification requirements and have received the Certified Records Manager (CRM) designation. As the field of information and records management moves toward standardization, and as the application of new technologies and technicalities complicate the measurement and demonstration of professional competence, the need for a means of identifying persons who have basic competency increases. The ICRM is providing such a means by testing and certifying basic knowledge. More and more job announcements are requiring this evidence of competency. Unfortunately, as an organization, NIRMA has a relatively small number of CRMs. The goal of the ICRM Development Group is two-fold; (1) to encourage NIRMA members to obtain their certification by providing basic information and support and; (2) to develop the Nuclear Specialist test module which will demonstrate that bearers have demonstrated expertise in nuclear records management as well as basic competencies. This report covers the examination process.

  4. FACULTY OF MANAGEMENT The University of Lethbridge's Faculty of Management offers five undergraduate Certificate programs in

    E-Print Network [OSTI]

    Seldin, Jonathan P.

    in Organizations Management 4390 - Leading Organizational Change Management 4901 - Applied Consulting One ofFACULTY OF MANAGEMENT The University of Lethbridge's Faculty of Management offers five undergraduate Certificate programs in · Finance · General Management · Human Resource Management and Labour

  5. Property Management Major Bachelor of Science in Apparel, Housing, and Resource Management

    E-Print Network [OSTI]

    Zallen, Richard

    Property Management Major Bachelor of Science in Apparel, Housing, and Resource Management College Management Major + AHRM 2664 (2675) Introduction to Residential Property Management + AHRM 2674 (2676) Multifamily Property Management and Operations + AHRM 3634 Managing Affordable and Specialized Housing

  6. Oil field management system

    DOE Patents [OSTI]

    Fincke, James R.

    2003-09-23

    Oil field management systems and methods for managing operation of one or more wells producing a high void fraction multiphase flow. The system includes a differential pressure flow meter which samples pressure readings at various points of interest throughout the system and uses pressure differentials derived from the pressure readings to determine gas and liquid phase mass flow rates of the high void fraction multiphase flow. One or both of the gas and liquid phase mass flow rates are then compared with predetermined criteria. In the event such mass flow rates satisfy the predetermined criteria, a well control system implements a correlating adjustment action respecting the multiphase flow. In this way, various parameters regarding the high void fraction multiphase flow are used as control inputs to the well control system and thus facilitate management of well operations.

  7. Storage resource manager

    SciTech Connect (OSTI)

    Perelmutov, T.; Bakken, J.; Petravick, D.; /Fermilab

    2004-12-01

    Storage Resource Managers (SRMs) are middleware components whose function is to provide dynamic space allocation and file management on shared storage components on the Grid[1,2]. SRMs support protocol negotiation and reliable replication mechanism. The SRM standard supports independent SRM implementations, allowing for a uniform access to heterogeneous storage elements. SRMs allow site-specific policies at each location. Resource Reservations made through SRMs have limited lifetimes and allow for automatic collection of unused resources thus preventing clogging of storage systems with ''orphan'' files. At Fermilab, data handling systems use the SRM management interface to the dCache Distributed Disk Cache [5,6] and the Enstore Tape Storage System [15] as key components to satisfy current and future user requests [4]. The SAM project offers the SRM interface for its internal caches as well.

  8. Computer memory management system

    DOE Patents [OSTI]

    Kirk, III, Whitson John (Greenwood, MO)

    2002-01-01

    A computer memory management system utilizing a memory structure system of "intelligent" pointers in which information related to the use status of the memory structure is designed into the pointer. Through this pointer system, The present invention provides essentially automatic memory management (often referred to as garbage collection) by allowing relationships between objects to have definite memory management behavior by use of coding protocol which describes when relationships should be maintained and when the relationships should be broken. In one aspect, the present invention system allows automatic breaking of strong links to facilitate object garbage collection, coupled with relationship adjectives which define deletion of associated objects. In another aspect, The present invention includes simple-to-use infinite undo/redo functionality in that it has the capability, through a simple function call, to undo all of the changes made to a data model since the previous `valid state` was noted.

  9. Sustainable Energy Management Programs 

    E-Print Network [OSTI]

    Hanner, S.

    2014-01-01

    stream_source_info ESL-KT-14-11-45.pdf.txt stream_content_type text/plain stream_size 4632 Content-Encoding UTF-8 stream_name ESL-KT-14-11-45.pdf.txt Content-Type text/plain; charset=UTF-8 Sustainable Energy Management... Existing Conditions • Develop Plan • Implement and Monitor Program ESL-KT-14-11-45 CATEE 2014: Clean Air Through Efficiency Conference, Dallas, Texas Nov. 18-20 Sustainable Programs Feature – District Commitment – Qualified Energy Manager – Facility...

  10. Radioactive Waste Management Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    This Manual further describes the requirements and establishes specific responsibilities for implementing DOE O 435.1, Radioactive Waste Management, for the management of DOE high-level waste, transuranic waste, low-level waste, and the radioactive component of mixed waste. Change 1 dated 6/19/01 removes the requirement that Headquarters is to be notified and the Office of Environment, Safety and Health consulted for exemptions for use of non-DOE treatment facilities. Certified 1-9-07. Admin Chg 2, dated 6-8-11, supersedes DOE M 435.1-1 Chg 1.

  11. Environmental Management System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansasCommunitiesof Energy Services » Program Management »Management

  12. Management | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousandReport)Price (Dollars perManagement CouncilManagement Directors

  13. NS&T MANAGEMENT OBSERVATIONS

    SciTech Connect (OSTI)

    Gianotto, David

    2014-06-01

    The INL Management Observation Program (MOP) is designed to improve managers and supervisors understanding of work being performed by employees and the barriers impacting their success. The MOP also increases workers understanding of managements’ expectations as they relate to safety, security, quality, and work performance. Management observations (observations) are designed to improve the relationship and trust between employees and managers through increased engagement and interactions between managers and researchers in the field. As part of continuous improvement, NS&T management took initiative to focus on the participation and quality of observations in FY 14. This quarterly report is intended to (a) summarize the participation and quality of management’s observations, (b) assess observations for commonalities or trends related to facility or process barriers impacting research, and (c) provide feedback and make recommendations for improvements NS&T’s MOP.

  14. NS&T Management Observations

    SciTech Connect (OSTI)

    Gianotto, David

    2014-09-01

    The INL Management Observation Program (MOP) is designed to improve managers and supervisors understanding of work being performed by employees and the barriers impacting their success. The MOP also increases workers understanding of managements’ expectations as they relate to safety, security, quality, and work performance. Management observations (observations) are designed to improve the relationship and trust between employees and managers through increased engagement and interactions between managers and researchers in the field. As part of continuous improvement, NS&T management took initiative to focus on the participation and quality of observations in FY 14. This quarterly report is intended to (a) summarize the participation and quality of management’s observations, (b) assess observations for commonalities or trends related to facility or process barriers impacting research, and (c) provide feedback and make recommendations for improvements NS&T’s MOP.

  15. Radioactive Waste Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    The objective of this Order is to ensure that all Department of Energy (DOE) radioactive waste is managed in a manner that is protective of worker and public health and safety and the environment. Supersedes DOE O 5820.2A. Chg 1 dated 8-28-01. Certified 1-9-07.

  16. Best Environmental Management Practices

    E-Print Network [OSTI]

    protection 3. Aesthetics Acceptable ways for managing mortality include: 1. Rendering 2. Composting 3, and composting methods recycle the nutrients. The other methods, in essence, waste the nutrients. Rendering by rendering plant vehicles and personnel. Composting Composting is the controlled aerobic biological

  17. Managing environmental information

    SciTech Connect (OSTI)

    Solyst, J. [Chemical Manufacturers Association, Arlington, VA (United States)

    1998-12-31

    The public`s right to know about environmental policy has moved to the forefront with the technological advances in recent years. Congress has not kept pace with these developments having twice considered and twice rejected legislation that is necessary in this field. Congress should provide leadership to the Environmental Protection Agency (EPA) for a broad strategy to improve information resources and management.

  18. Forest Resources and Management

    E-Print Network [OSTI]

    the forest resource. Our aim is that British forests ­ from their creation to maturity and regeneration and harvesting, and the physical properties of stands, trees and timber. Scope of our work Our research focuses expertise in forecasting forest growth is now applied to carbon assessment and management. We also work

  19. Hazardous Waste Management Training

    E-Print Network [OSTI]

    Dai, Pengcheng

    Hazardous Waste Management Training Persons (including faculty, staff and students) working with hazardous materials should receive annual training that addresses storage, use, and disposal of hazardous before handling hazardous waste. Departments are re- quired to keep records of training for as long

  20. Electrical Demand Management 

    E-Print Network [OSTI]

    Fetters, J. L.; Teets, S. J.

    1983-01-01

    The Demand Management Plan set forth in this paper has proven to be a viable action to reduce a 3 million per year electric bill at the Columbus Works location of Western Electric. Measures are outlined which have reduced the peak demand 5% below...

  1. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-10-29

    To establish policy and to assign and describe roles and responsibilities for the Department of Energy (DOE) Emergency Management System. (This is an administrative change to DOE O 151.1A). Canceled by DOE O 151.1C. Cancels DOE O 151.1A.

  2. Integrated Safety Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-04-25

    The order ensures that DOE/NNSA, systematically integrates safety into management and work practices at all levels, so that missions are accomplished efficiently while protecting the workers, the public, and the environment. Supersedes DOE M 450.4-1 and DOE M 411.1-1C

  3. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-08-21

    The Order establishes policy and assigns and describes roles and responsibilities for the DOE Emergency Management System. Cancels DOE 5500.1B, DOE 5500.2B, DOE 5500.3A, DOE 5500.4A, 5500.5A,5500.7B, 5500.8A, 5500.9A, DOE 5500.10

  4. Rice Insect Management

    E-Print Network [OSTI]

    Drees, Bastiaan M.

    1983-01-01

    8-1445 rexas Agricultural Extension Service, The Texas A&M University System Zerle L. Carpenter, Director, College Station, Texas Table of Contents Page Introduction .......................?...... Insect Management Practices.... . . . . . . . . . . . . . . . . . . . . . . . . . . .. 7 Other Insect Pests of Texas Rice. . . . . . . . . . . . . . 8 Texas Rice Production Practices. . . . . . . . . . . . . .. 9 1983 Rice Insect Control Suggestions .......... \\0 Acknowledgment This publication has been prepared to assist...

  5. Load Management Made Simple 

    E-Print Network [OSTI]

    Schneider, K.

    1985-01-01

    Company have moved to a demand side or load management mode which seeks to influence customers to change electric usage patterns to more efficiently use available generating capacity. Since 1970, the TUEC system peak demand has more than doubled from about...

  6. Purge water management system

    DOE Patents [OSTI]

    Cardoso-Neto, J.E.; Williams, D.W.

    1995-01-01

    A purge water management system is described for effectively eliminating the production of purge water when obtaining a groundwater sample from a monitoring well. In its preferred embodiment, the purge water management system comprises an expandable container, a transportation system, and a return system. The purge water management system is connected to a wellhead sampling configuration, typically permanently installed at the well site. A pump, positioned with the monitoring well, pumps groundwater through the transportation system into the expandable container, which expands in direct proportion with volume of groundwater introduced, usually three or four well volumes, yet prevents the groundwater from coming into contact with the oxygen in the air. After this quantity of groundwater has been removed from the well, a sample is taken from a sampling port, after which the groundwater in the expandable container can be returned to the monitoring well through the return system. The purge water management system prevents the purge water from coming in contact with the outside environment, especially oxygen, which might cause the constituents of the groundwater to oxidize. Therefore, by introducing the purge water back into the monitoring well, the necessity of dealing with the purge water as a hazardous waste under the Resource Conservation and Recovery Act is eliminated.

  7. Position Management and Classification

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-04-01

    The order establishes departmental requirements and responsibilities for classifying positions using the general schedule (GS) and federal wage system (FWS) standards and to develop and administer a sound position management and classification program. Supersedes DOE O 325.2, dated 4-1-15.

  8. Position Management and Classification

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-04-01

    The order establishes departmental requirements and responsibilities for classifying positions using general schedule (GS) and federal wage system (FWS) standards and for developing and administering a sound position management and classification program within the Department. Cancels Chapter VII of DOE O 320.1. Canceled by DOE O 325.2 Chg 1 (Admin Chg), 9-1-15.

  9. Integrated Safety Management Policy

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-04-25

    The policy establishes DOE's expectation for safety, including integrated safety management that will enable the Department’s mission goals to be accomplished efficiently while ensuring safe operations at all departmental facilities and activities. Supersedes DOE P 450.4, DOE P 411.1, DOE P 441.1, DOE P 450.2A, and DOE P 450.7

  10. ENGINEERING MANAGEMENT AND LEADERSHIP

    E-Print Network [OSTI]

    Eagar, Thomas W.

    ENGINEERING MANAGEMENT AND LEADERSHIP Where did we come from? Where are we going? How do we get · If it works but no one knows why, it's ENGINEERING #12;The scientist explains that which exists; The engineer creates that which never was. Theodore von Karman #12;Engineer - Noun (from French "to contrive

  11. Office of Quality Management

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Office of Quality Management develops and interprets Government-wide policies and procedures and conducts training to ensure the accurate identification of information and documents that must be classified or controlled under statute or Executive order to protect the national security and controlled unclassified Official Use Only information for the effective operation of the Government.

  12. OFFICE FOR EMERGENCY MANAGEMENT

    Office of Legacy Management (LM)

    OFFICE FOR EMERGENCY MANAGEMENT 155OP STREETNW. WiSHINGTON. D.C. ' , iQns 25,19&L At-t :. I' .' at l530 P Btmat, IO&, XtwMn&m, 0. 6., at 9130 A.Jb Sa 1 llmbemupoftbaaomlttaal8f...

  13. Purge water management system

    DOE Patents [OSTI]

    Cardoso-Neto, Joao E. (North Augusta, SC); Williams, Daniel W. (Aiken, SC)

    1996-01-01

    A purge water management system for effectively eliminating the production of purge water when obtaining a groundwater sample from a monitoring well. In its preferred embodiment, the purge water management system comprises an expandable container, a transportation system, and a return system. The purge water management system is connected to a wellhead sampling configuration, typically permanently installed at the well site. A pump, positioned with the monitoring well, pumps groundwater through the transportation system into the expandable container, which expands in direct proportion with volume of groundwater introduced, usually three or four well volumes, yet prevents the groundwater from coming into contact with the oxygen in the air. After this quantity of groundwater has been removed from the well, a sample is taken from a sampling port, after which the groundwater in the expandable container can be returned to the monitoring well through the return system. The purge water management system prevents the purge water from coming in contact with the outside environment, especially oxygen, which might cause the constituents of the groundwater to oxidize. Therefore, by introducing the purge water back into the monitoring well, the necessity of dealing with the purge water as a hazardous waste under the Resource Conservation and Recovery Act is eliminated.

  14. Mobile Technology Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2014-05-15

    The order establishes requirements, assigns responsibilities, and provides guidance for federal mobile technology management and employee use of both government furnished and personally-owned mobile devices within DOE and NNSA. Establishes requirements for use of User Agreements to govern mobile devices used for official duties. Does not cancel other directives.

  15. Managing America's solid waste

    SciTech Connect (OSTI)

    Phillips, J. A.

    1998-09-15

    This report presents an historical overview of the federal role in municipal solid waste management from 1965 to approximately 1995. Attention is focuses on the federal role in safeguarding public health, protecting the environment, and wisely using material and energy resources. It is hoped that this report will provide important background for future municipal solid waste research and development initiatives.

  16. Radioactive Waste Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    The objective of this Order is to ensure that all Department of Energy (DOE) radioactive waste is managed in a manner that is protective of worker and public health and safety and the environment. Cancels DOE O 5820.2A

  17. Managing projects utilizing self-managed teams and managerial toolkits

    E-Print Network [OSTI]

    Mathur, Praveen, S. M. Massachusetts Institute of Technology

    2009-01-01

    Project Management is an essential function in most software companies today. With increasing complexity and inter connectivity between software projects, it is not surprising that managing such large scale development ...

  18. Configuration Management for Open Source Software

    E-Print Network [OSTI]

    Bendix, Lars

    , configuration selection, workspace management, concurrency control, change management and release management. In this position paper, we do not present our full study, but just the change management task, which is where OSS configuration management differs mostly from CSD configuration management. Change management processes compared

  19. Privacy Management at UC Information and Records Management

    E-Print Network [OSTI]

    Hickman, Mark

    or criminal records. See a full list of the types of information collected about individuals at UC in SectionPrivacy. Privacy Management at UC Information and Records Management (IRM) www Records Management 3 1. Introduction Information that staff or contractors create and collect at UC needs

  20. Intellectual Property Management and Markets Intellectual Property Management and Markets

    E-Print Network [OSTI]

    Intellectual Property Management and Markets Intellectual Property Management and Markets Program are becoming cen- tral to the modern economy. IIT's Master of Intellectual Property Management and Markets exploitation. Graduates of this program will be equipped to take a strategic or leadership role leveraging

  1. Nutrient Management Module No. 13 Regulation and Management

    E-Print Network [OSTI]

    Lawrence, Rick L.

    , as seen in Table 1. Additional manure characteristics can be found in NRCS's Agricultural Waste Management and swine manure contain about as much N as commercial fertilizer applied to cropland each year (DEQ, 1996Nutrient Management Module No. 13 Manure and Biosolids: Regulation and Management by Clain Jones

  2. Waste Management & Research290 Waste Manage Res 2002: 20: 290301

    E-Print Network [OSTI]

    Florida, University of

    Waste Management & Research290 Waste Manage Res 2002: 20: 290­301 Printed in UK ­ all rights reserved Copyright © ISWA 2002 Waste Management & Research ISSN 0734­242X Introduction Chromated copper of sorting technologies for CCA treated wood waste Monika Blassino Helena Solo-Gabriele University of Miami

  3. Project Management Plan Project Title: Natural Resources Management

    E-Print Network [OSTI]

    US Army Corps of Engineers

    DEFINITION. The NRM Gateway is a knowledge management resource, designed to serve the needs of the NRMP; · Preserve institutional knowledge; · Develop practical and agency-approved webpages that provide usefulProject Management Plan Project Title: Natural Resources Management (NRM) Gateway Website

  4. Earned Value Management System (EVMS)

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-05-06

    The Guide supports the Departments initiatives to improve program, project, and contract management through the implementation and surveillance of contractors earned value management systems. Canceled by DOE G 413.3-10A.

  5. Oklahoma Industrial Energy Management Program 

    E-Print Network [OSTI]

    Estes, C. B.; Turner, W. C.

    1980-01-01

    this, the Oklahoma Department of Energy designed a program to acquaint Oklahoma industry with the potential savings available through energy management and some basic techniques. The program is, entitled "Oklahoma Industrial Energy Management Program...

  6. Where do firms manage earnings?

    E-Print Network [OSTI]

    Dyreng, Scott D.

    Despite decades of research on how, why, and when companies manage earnings, there is a paucity of evidence about the geographic location of earnings management within multinational firms. In this study, we examine where ...

  7. Emergency Animal Management during Disasters 

    E-Print Network [OSTI]

    Dement, Angela

    2006-10-23

    This publication explains how communities and counties can incorporate animal issues into their emergency management plans. It explains what local plans should include, what role county Extension agents can play, and how animal management plans can...

  8. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 2000 prepared by: Data Management Group Joint Program PROCESSING ...................................................2 Text Based Data Retrieval System `drs'.................................2 Internet Browser Data Retrieval System (iDRS).....................3 Complex Data Requests

  9. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    iv Data Management Group Annual Report 2003 City of Hamilton City of Toronto GO Transit Regional of York Toronto Transit Commission The Data Management Group is a research program located ........................................................................................................ 3 Text-based Data Retrieval System `drs

  10. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 2001 prepared by: Data Management Group Joint Program..............................................................................2 Text Based Data Retrieval System `drs' ..........................................................2 Internet Browser Data Retrieval System (iDRS)..............................................3 Complex Data

  11. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 2002 prepared by: Data Management Group Joint Program Based Data Retrieval System `drs' ............................................... 3 Internet Browser Data Retrieval System (iDRS) .................................. 4 Complex Data Requests

  12. Environmental Management (EM) Cleanup Projects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-09-24

    The guide supports DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, and provides guidance on environmental management cleanup projects. Canceled by DOE N 251.105.

  13. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09

  14. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09.

  15. Departmental Cyber Security Management Policy

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-05-08

    The Departmental Cyber Security Management (DCSM) Policy was developed to further clarify and support the elements of the Integrated Safeguards and Security Management (ISSM) Policy regarding cyber security. Certified 9-23-10. No cancellation.

  16. ENERGY STAR Portfolio Manager 201

    Office of Energy Efficiency and Renewable Energy (EERE)

    Continue to learn about EPA’s new ENERGY STAR Portfolio Manager tool, with a deeper dive into more advanced functionalities such as: managing and tracking changes to your property uses over time;...

  17. ENERGY STAR Portfolio Manager 101

    Office of Energy Efficiency and Renewable Energy (EERE)

    Join us as we introduce and demonstrate the core functionality of EPA’s ENERGY STAR Portfolio Manager tool. Attendees will learn how to: navigate Portfolio Manager; add a property and enter details...

  18. Essays on Competitive Strategy and Innovation Management

    E-Print Network [OSTI]

    Wang, Richard Dick

    2010-01-01

    Competitive Position. Strategic Management Journal, 21(7):Strategic Balance. Strategic Management Journal, 20(2): 147–Automobile Industry. Strategic Management Journal, 23: 307-

  19. Managing Knowledge Workers in Global Value Chains

    E-Print Network [OSTI]

    Brown, Clair; Linden, Greg

    2010-01-01

    Strategic Alliances. ” Strategic Management Journal, v.12,Overseas Knowledge. ” Strategic Management Journal, 22(4):Performance. ” Strategic Management Journal, 28(13): 1319–

  20. Robust Maintenance Policies in Asset Management

    E-Print Network [OSTI]

    Kuhn, Kenneth D.; Madanat, Samer M.

    2005-01-01

    Repair Policies in Asset Management Under Uncertain FacilityMAINTENANCE POLICIES IN ASSET MANAGEMENT Kenneth D. KuhnBerkeley, USA ABSTRACT Asset management systems help public

  1. EIS-0200: Waste Management Programmatic Environmental Impact...

    Office of Environmental Management (EM)

    00: Waste Management Programmatic Environmental Impact Statement for Managing Treatment, Storage, and Disposal of Radioactive and Hazardous Waste EIS-0200: Waste Management...

  2. Performance Feedback to Improve Classroom Management Practices

    E-Print Network [OSTI]

    Garcia, Melissa

    2015-01-01

    Implementation of a classroom management program with urbanof evidence-based classroom management strategies throughbased practices in classroom management: Considerations for

  3. DOE Challenge Home Recommended Quality Management Provisions...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Recommended Quality Management Provisions DOE Challenge Home Recommended Quality Management Provisions DOE Challenge Home Recommended Quality Management Provisions. qm6-14-13.pdf...

  4. IT Project Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Management IT Project Management Qualification, Engineering and Quality Assurance The purpose of the Department of Energy (DOE) IT Project Management, Engineering, and Quality...

  5. Does Management Matter? Evidence from India

    E-Print Network [OSTI]

    Bloom, Nicholas; Eifert, Benn; Mahajan, Aprajit; McKenzie, David; Roberts, John

    2012-01-01

    DOES MANAGEMENT MATTER? EVIDENCE FROM INDIA Nicholas Bloomis whether differences in management practices across firmsTo investigate this, we ran a management field experiment on

  6. Performance Feedback to Improve Classroom Management Practices

    E-Print Network [OSTI]

    Garcia, Melissa

    2015-01-01

    teachers in behavior management: The PBISplus coachingand implementation of behavior management interventions inImplementation of a classroom management program with urban

  7. Pest Management For Grain Storage and Fumigation

    E-Print Network [OSTI]

    Dyer, Bill

    Pest Management For Grain Storage and Fumigation Seed Treatment -Pest Control- Grain Storage & Seed MANAGEMENT FOR GRAIN STORAGE AND FUMIGATION Introduction .................................................................................................................................................................. 12 Resistance Management Issues

  8. Federal Energy Management Program Report Template | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Federal Energy Management Program Report Template Federal Energy Management Program Report Template Template to create reports for the Federal Energy Management Program (FEMP)...

  9. Interagency Energy Management Task Force Members

    Broader source: Energy.gov [DOE]

    The Interagency Energy Management Task Force is led by the Federal Energy Management Program director. Members include energy and sustainability managers from federal agencies.

  10. Sandia Energy - Bureau of Land Management

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bureau of Land Management Home Climate & Earth Systems Sustainable Subsurface Energy Development Program Leadership Bureau of Land Management Bureau of Land ManagementMaelyn...

  11. 5) Management ii) Mechanical methods

    E-Print Network [OSTI]

    Nowak, Robert S.

    5) Management c) Control ii) Mechanical methods = manually or mechanically damaging plants #12;5) Management c) Control ii) Mechanical methods Advantages · Generally much less public opposition #12;5) Management c) Control ii) Mechanical methods Advantages · Generally much less public opposition · Works well

  12. Quantitative Risk Management Rudiger Frey

    E-Print Network [OSTI]

    Frey, Rüdiger

    Lecture Quantitative Risk Management R¨udiger Frey Universit¨at Leipzig Wintersemester 2010 risk management C. Introduction to Portfolio Credit Derivatives c 2010 (Frey) 1 #12;A. Introduction of counterparties. Measuring and management of credit risk is of high importance for financial institutions

  13. Algorithmic Aspects of Risk Management

    E-Print Network [OSTI]

    Gehani, Ashish

    Algorithmic Aspects of Risk Management Ashish Gehani1 , Lee Zaniewski2 , and K. Subramani2 1 SRI International 2 West Virginia University Abstract. Risk analysis has been used to manage the security of sys configuration. This allows risk management to occur in real time and reduces the window of exposure to attack

  14. Therisk management-risk assessmentinterface

    E-Print Network [OSTI]

    Short, Daniel

    Therisk management- risk assessmentinterface Lastin afve-pan seies oncancernskassessmznt Paul.Evenso,Fuly sat- isfactorysolutioDsto the risk manage- menlDr.blemsof cancerafributableto industrialy relardE Dislc.,Jr. Hoqston,Tet:nO24 Everyonpracticesrisk management daily to rcduccrisksof nl3ny khds

  15. Regional Summary Pacific Management Context

    E-Print Network [OSTI]

    . Bocaccio, Pacific ocean perch, cowcod, and darkblotched and widow rockfish are currently in rebuildingRegional Summary Pacific Management Context The Pacific Region includes California, Oregon, and Washington. Federal fisheries in this region are managed by the Pacific Fishery Management Council (PFMC

  16. UCI Equipment Management Peter's Exchange

    E-Print Network [OSTI]

    Wood, Marcelo A.

    the Asset Retirement Global document available in KFS under KFS Capital Asset Management (as the EIMR formUCI Equipment Management Peter's Exchange (UCI Surplus Sales) SURPLUS PICK-UP REQUEST Department) Phone: (949) 824-6111, 6447, 6519, 6100 Fax this form to (949) 824-4115, or e-mail Equipment-Management

  17. Key Management in Historical Context

    E-Print Network [OSTI]

    ;Rolling Keys Why change keys? --- cryptoperiod (intrinsic to cryptosystem) --- management issuesKey Management in Historical Context Whitfield Diffie Internet Corporation for Assigned Names to become the security or insecurity of the message. #12;Key management systems both reflect and shape

  18. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT AND ENVIRONMENTAL HEALTH & INSTRUCTIONAL SAFETY 2009 ANNUAL REPORTS #12;2009 Annual Report Page 2 RISK MANAGEMENT I. Program Cost One method to assess the effectiveness of the University's risk management program is to compare the annual cost

  19. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT 2003-04 ANNUAL REPORT OFFICE OF UNIVERSITY RISK MANAGEMENT #12;2 I. Introduction "Of course you have to go out on a limb sometimes, that's where the best outcome in a changing environment, is the essence of risk management.3 This Report was developed

  20. CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT

    E-Print Network [OSTI]

    de Lijser, Peter

    CALIFORNIA STATE UNIVERSITY, FULLERTON RISK MANAGEMENT 2010 ANNUAL REPORT #12;2010 Annual Report Page 2 I. Program Cost One method to assess the effectiveness of the University's risk management,538 $ 197,196 TOTAL Risk Management Costs $ 4,675,390 $ 4,541,975 $ 3,764,749 $ 3,703,959 $ 4

  1. Professional Certificate in Risk Management

    E-Print Network [OSTI]

    Carleton University

    Professional Certificate in Risk Management 2010 Program 3 Part-time Courses CRM01: Essentials of Risk Management ­ Next Session Fall 2010 CRM02: Risk Control ­ Jan. 12 - April 26, 2010 CRM03: Risk to apply for the Canadian Risk Management (CRM) designation. #12;Professional Certificate in Risk

  2. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 1997 #12;Data Management Group Annual Report 1997 A co-operative project that is jointly funded by members of the Toronto Area Transportation Planning Data Collection: (416) 978-3941 #12;Data Management Group 1997 Annual Report Table of Contents 1 INTRODUCTION

  3. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 2004 City of Hamilton City of Toronto GO Transit Regional of York Toronto Transit Commission The Data Management Group is a research program located of the funding partners: Ministry of Transportation, Ontario #12;SUMMARY The Data Management Group (DMG

  4. InterplanetarySupply Chain Management &

    E-Print Network [OSTI]

    de Weck, Olivier L.

    InterplanetarySupply Chain Management & LogisticsArchitectures 2005-2007 MIT JPL USA PSI InterplanetarySupply Chain Management & LogisticsArchitectures 2005-2007 MIT JPL USA PSI Logistics Lessons Learned in NASA Space Flight Interplanetary Supply Chain Management & Logistics Architectures William A

  5. Waste Management Coordinating Lead Authors

    E-Print Network [OSTI]

    Columbia University

    10 Waste Management Coordinating Lead Authors: Jean Bogner (USA) Lead Authors: Mohammed Abdelrafie Ahmed, C. Diaz, A. Faaij, Q. Gao, S. Hashimoto, K. Mareckova, R. Pipatti, T. Zhang, Waste Management University Press, Cambridge, United Kingdom and New York, NY, USA. #12;586 Waste Management Chapter 10 Table

  6. Data Management Group Annual Report

    E-Print Network [OSTI]

    Toronto, University of

    Data Management Group Annual Report 2000 prepared by: Data Management Group Joint Program ...........................................18 #12;i SUMMARY The Data Management Group (DMG), in cooperation with the funding agencies, has. In addition, there were 26 complex requests for data that required a customized computer program. Eight

  7. RESOLVING EQUIVOCALITY IN ECOSYSTEM MANAGEMENT

    E-Print Network [OSTI]

    RESOLVING EQUIVOCALITY IN ECOSYSTEM MANAGEMENT by LARRY DENNIS STURM WOLFE Bachelor of Science OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in the School of Resource and Environmental Management of Philosophy Title of Dissertation: Resolving Equivocality in Ecosystem Management Examining Committee: Chair

  8. Engineering Management Postgraduate MSc Program

    E-Print Network [OSTI]

    Arnold, Anton

    Engineering Management Postgraduate MSc Program Master of Science (MSc) 3 semesters, part-time engineering.tuwien.ac.at Vienna University of Technology M ScEngine ering Manag em ent 20Years #12;Engineering Management Your key to the top engineering league This part-time MSc Program is tailor-made for the demands

  9. NUSTAR User Guide Checklist Management

    E-Print Network [OSTI]

    Fleming, Andrew J.

    NUSTAR User Guide Checklist Management Page 1 of 3 Updated : 26/11/2012 Checklist Management Trigger: If a student has a checklist on their record that is associated with a restriction. Pathway: Campus Community>Checklists>Checklists Management - Person 1. Insert the student number or other

  10. Weed Management in Organic Crops

    E-Print Network [OSTI]

    Guiltinan, Mark

    Weed Management in Organic Crops Research Results Update Bill Curran Penn State University #12;Weed management tactics for organic production · Crop rotation · Cover crops - dead mulches and green manures · Primary and secondary tillage · Irrigation and drainage · Crop residue management · Planting date

  11. Energy Management and Conservation Plan

    E-Print Network [OSTI]

    Energy Management and Conservation Plan December 2005 #12;Texas Transportation Institute December 2005 Energy Management and Conservation Plan Page 2 of 24 Table of Contents Section One: Executive: Reporting Progress #12;Texas Transportation Institute December 2005 Energy Management and Conservation Plan

  12. Pharmaceutical Waste Management Under Uncertainty

    E-Print Network [OSTI]

    Linninger, Andreas A.

    Pharmaceutical Waste Management Under Uncertainty Andreas A. Linninger and Aninda Chakraborty of their benefits and costs constitutes a formidable task. Designing plant-wide waste management policies assuming this article addresses the problem of finding optimal waste management policies for entire manufacturing sites

  13. Southern Region Watershed Management Project

    E-Print Network [OSTI]

    and technology transfer programs. #12;Southern Region Watershed Management Project September 15, 2000 and networking both internally and with other regional water resources management programs, promoted technology1 Southern Region Watershed Management Project September 15, 2000 to September 14, 2005 Terminal

  14. Environmental Management System Plan

    SciTech Connect (OSTI)

    Fox, Robert; Thorson, Patrick; Horst, Blair; Speros, John; Rothermich, Nancy; Hatayama, Howard

    2009-03-24

    Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management establishes the policy that Federal agencies conduct their environmental, transportation, and energy-related activities in a manner that is environmentally, economically and fiscally sound, integrated, continually improving, efficient, and sustainable. The Department of Energy (DOE) has approved DOE Order 450.1A, Environmental Protection Program and DOE Order 430.2B, Departmental Energy, Renewable Energy and Transportation Management as the means of achieving the provisions of this Executive Order. DOE Order 450.1A mandates the development of Environmental Management Systems (EMS) to implement sustainable environmental stewardship practices that: (1) Protect the air, water, land, and other natural and cultural resources potentially impacted by facility operations; (2) Meet or exceed applicable environmental, public health, and resource protection laws and regulations; and (3) Implement cost-effective business practices. In addition, the DOE Order 450.1A mandates that the EMS must be integrated with a facility's Integrated Safety Management System (ISMS) established pursuant to DOE P 450.4, 'Safety Management System Policy'. DOE Order 430.2B mandates an energy management program that considers energy use and renewable energy, water, new and renovated buildings, and vehicle fleet activities. The Order incorporates the provisions of the Energy Policy Act of 2005 and Energy Independence and Security Act of 2007. The Order also includes the DOE's Transformational Energy Action Management initiative, which assures compliance is achieved through an Executable Plan that is prepared and updated annually by Lawrence Berkeley National Laboratory (LBNL, Berkeley Lab, or the Laboratory) and then approved by the DOE Berkeley Site Office. At the time of this revision to the EMS plan, the 'FY2009 LBNL Sustainability Executable Plan' represented the most current Executable Plan. These DOE Orders and associated policies establish goals and sustainable stewardship practices that are protective of environmental, natural, and cultural resources, and take a life cycle approach that considers aspects such as: (1) Acquisition and use of environmentally preferable products; (2) Electronics stewardship; (3) Energy conservation, energy efficiency, and renewable energy; (4) Pollution prevention, with emphasis on toxic and hazardous chemical and material reduction; (5) Procurement of efficient energy and water consuming materials and equipment; (6) Recycling and reuse; (7) Sustainable and high-performance building design; (8) Transportation and fleet management; and (9) Water conservation. LBNL's approach to sustainable environmental stewardship required under Order 450.1A poses the challenge of implementing its EMS in a compliance-based, performance-based, and cost-effective manner. In other words, the EMS must deliver real and tangible business value at a minimal cost. The purpose of this plan is to describe Berkeley Lab's approach for achieving such an EMS, including an overview of the roles and responsibilities of key Laboratory parties. This approach begins with a broad-based environmental policy consistent with that stated in Chapter 11 of the LBNL Health and Safety Manual (PUB-3000). This policy states that Berkeley Lab is committed to the following: (1) Complying with applicable environmental, public health, and resource conservation laws and regulations. (2) Preventing pollution, minimizing waste, and conserving natural resources. (3) Correcting environmental hazards and cleaning up existing environmental problems, and (4) Continually improving the Laboratory's environmental performance while maintaining operational capability and sustaining the overall mission of the Laboratory. A continual cycle of planning, implementing, evaluating, and improving processes will be performed to achieve goals, objectives, and targets that will help LBNL carry out this policy. Each year, environmental aspects will be identified and their impacts to the environm

  15. Master of Science in Engineering and Technology Management Engineering Management Concentration Management of Technology Concentration

    E-Print Network [OSTI]

    Selmic, Sandra

    514 Statistical Analysis for Six Sigma INEN 502 Operations Research Methods for Six Sigma INEN 502 Operations Research Methods INEN 518 Project Management MGMT 470 Personnel Management ENGR 566 Six Sigma and Quality

  16. Mesquite Ecology and Management 

    E-Print Network [OSTI]

    Lyons, Robert K.; Rector, Barron S.

    2009-05-12

    term, incorporating follow-up treat- ments to maintain mesquite densities at a level that meets landowner goals. Density considerations Mesquite may be managed by both broadcast and indi- vidual plant treatment methods. For thick stands (more than... 400 trees per acre), the preferred method is usually a broadcast method such as aerial spraying. However, an- other treatment option might be mechanical control? grubbing, chaining, and root plowing (for more informa- tion on these methods, see...

  17. Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1995-09-25

    The order establishes policy, and assigns and describes roles and responsibilities for the DOE Emergency Management System. DOE 5500.1B Chg 1; DOE 5500.2B Chg 1; DOE 5500.3A Chg 1; DOE 5500.4A; DOE 5500.5A; DOE 5500.7B; DOE 5500.8A; DOE 5500.9A, and DOE 5500.10A Chg 1. Canceled by DOE O 151.1A.

  18. Conditional data watchpoint management

    DOE Patents [OSTI]

    Burdick, Dean Joseph (Austin, TX); Vaidyanathan, Basu (Austin, TX)

    2010-08-24

    A method, system and computer program product for managing a conditional data watchpoint in a set of instructions being traced is shown in accordance with illustrative embodiments. In one particular embodiment, the method comprises initializing a conditional data watchpoint and determining the watchpoint has been encountered. Upon that determination, examining a current instruction context associated with the encountered watchpoint prior to completion of the current instruction execution, further determining a first action responsive to a positive context examination; otherwise, determining a second action.

  19. Accident management information needs

    SciTech Connect (OSTI)

    Hanson, D.J.; Ward, L.W.; Nelson, W.R.; Meyer, O.R. (EG and G Idaho, Inc., Idaho Falls, ID (USA))

    1990-04-01

    In support of the US Nuclear Regulatory Commission (NRC) Accident Management Research Program, a methodology has been developed for identifying the plant information needs necessary for personnel involved in the management of an accident to diagnose that an accident is in progress, select and implement strategies to prevent or mitigate the accident, and monitor the effectiveness of these strategies. This report describes the methodology and presents an application of this methodology to a Pressurized Water Reactor (PWR) with a large dry containment. A risk-important severe accident sequence for a PWR is used to examine the capability of the existing measurements to supply the necessary information. The method includes an assessment of the effects of the sequence on the measurement availability including the effects of environmental conditions. The information needs and capabilities identified using this approach are also intended to form the basis for more comprehensive information needs assessment performed during the analyses and development of specific strategies for use in accident management prevention and mitigation. 3 refs., 16 figs., 7 tabs.

  20. Life Cycle Asset Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1998-10-14

    (The following directives are deleted or consolidated into this Order and shall be phased out as noted in Paragraph 2: DOE 1332.1A; DOE 4010.1A; DOE 4300.1C; DOE 4320.1B; DOE 4320.2A; DOE 4330.4B; DOE 4330.5; DOE 4540.1C; DOE 4700.1). This Order supersedes specific project management provisions within DOE O 430.1A, LIFE CYCLE ASSET MANAGEMENT. The specific paragraphs canceled by this Order are 6e(7); 7a(3); 7b(11) and (14); 7c(4),(6),(7),(11), and (16); 7d(4) and (8); 7e(3),(10), and (17); Attachment 1, Definitions (item 30 - Line Item Project, item 42 - Project, item 48 - Strategic System); and Attachment 2, Contractor Requirements Document (paragraph 1d regarding a project management system). The remainder of DOE O 430.1A remains in effect. Cancels DOE O 430.1. Canceled by DOE O 413.3.

  1. Environmental management activities

    SciTech Connect (OSTI)

    1997-07-01

    The Office of Environmental Management (EM) has been delegated the responsibility for the Department of Energy`s (DOE`s) cleanup of the nuclear weapons complex. The nature and magnitude of the waste management and environmental remediation problem requires the identification of technologies and scientific expertise from domestic and foreign sources. Within the United States, operational DOE facilities, as well as the decontamination and decommissioning of inactive facilities, have produced significant amounts of radioactive, hazardous, and mixed wastes. In order to ensure worker safety and the protection of the public, DOE must: (1) assess, remediate, and monitor sites and facilities; (2) store, treat, and dispose of wastes from past and current operations; and (3) develop and implement innovative technologies for environmental restoration and waste management. The EM directive necessitates looking beyond domestic capabilities to technological solutions found outside US borders. Following the collapse of the Soviet regime, formerly restricted elite Soviet scientific expertise became available to the West. EM has established a cooperative technology development program with Russian scientific institutes that meets domestic cleanup objectives by: (1) identifying and accessing Russian EM-related technologies, thereby leveraging investments and providing cost-savings; (2) improving access to technical information, scientific expertise, and technologies applicable to EM needs; and (3) increasing US private sector opportunities in Russian in EM-related areas.

  2. Astronomical Data Management

    E-Print Network [OSTI]

    Ray Norris; Heinz Andernach; Guenther Eichhorn; Francoise Genova; Elizabeth Griffin; Robert Hanisch; Ajit Kembhavi; Robert Kennicutt; Anita Richards

    2006-11-01

    We present a summary of the major contributions to the Special Session on Data Management held at the IAU General Assembly in Prague in 2006. While recent years have seen enormous improvements in access to astronomical data, and the Virtual Observatory aims to provide astronomers with seamless access to on-line resources, more attention needs to be paid to ensuring the quality and completeness of those resources. For example, data produced by telescopes are not always made available to the astronomical community, and new instruments are sometimes designed and built with insufficient planning for data management, while older but valuable legacy data often remain undigitised. Data and results published in journals do not always appear in the data centres, and astronomers in developing countries sometimes have inadequate access to on-line resources. To address these issues, an 'Astronomers Data Manifesto' has been formulated with the aim of initiating a discussion that will lead to the development of a 'code of best practice' in astronomical data management.

  3. Effective risk management

    SciTech Connect (OSTI)

    Ball, C.J. [Corpfinance International Ltd., Toronto (Canada)

    1997-01-01

    Most independent power financial proposals contain one or more elements of a non-recourse nature. Traditionally, this means prospective lenders will not have a substantial corporate credit or state guarantee standing behind a project loan, which forces attention to be focused on a single asset as the security and debt repayment source. While this major risk remains present, if properly understood, uncertainty can be mitigated and managed, including financial and development hazards inherent in hydropower projects. The specific risk points that a project developer or sponsor must satisfy from the lender`s purposes are numerous. However, they can be grouped primarily into seven key risk areas: project profile, site securing, power sales agreements, government agreements, in-service management, construction and insurance. While a developer strives for a minimum internal rate of return of at least 20 percent, the lender`s expectations are much more modest. Often, developers need to place themselves in the proverbial shoes of the other entity, namely the independent lender, whose only attraction may be some interest, fee income and placement of capital in a safe investment which provides a return in an orderly and uninterrupted manner. Only then is it possible to objectively view and effectively manage the risks mentioned earlier.

  4. Evaluating next-generation environmental policy tools : adaptive management in the Bureau of Land Management

    E-Print Network [OSTI]

    Brandenburg, Peter (Peter J.)

    2005-01-01

    The U.S. Bureau of Land Management (BLM) has begun to embrace the concept adaptive management as an alternative to traditional natural resource planning and management models. Adaptive management may provide BLM managers ...

  5. MANAGEMENT CERTIFICATE FOR WOMEN (MCW) A Professional Certificate in Management Fundamentals & Skills

    E-Print Network [OSTI]

    Kranakis, Evangelos

    MANAGEMENT CERTIFICATE FOR WOMEN (MCW) A Professional Certificate in Management Fundamentals & Skills This program recognizes that women have different learning and management styles than do in management and responds to their learning styles by addressing personal management skills development

  6. Employee Motivation in Energy Management Programs 

    E-Print Network [OSTI]

    Hogeland, A. W.

    1982-01-01

    Effective management of energy requires the same degree of manager/employee motivation as other management responsibilities. Basically the same factors cause managers and employees to be motivated and effective. In this discussion, we will review...

  7. Supply Chain Management Faculty Brian Fugate

    E-Print Network [OSTI]

    of Operations Management, International Journal of Physical Distribution and Logistics Management, International conferences and has published in Journal of Operations Management, Journal of Business Logistics significant industry experience including positions in quality assurance and supply chain management. Dan

  8. School of Resource and Environmental Management

    E-Print Network [OSTI]

    of the concept of sustainable development requires competent stewardship and management of resources management, protected areas management, environmental impact assessment, and climate change. EachSchool of Resource and Environmental Management SIMON FRASER UNIVERSITY Sessional Instructor

  9. School of Resource and Environmental Management

    E-Print Network [OSTI]

    School of Resource and Environmental Management SIMON FRASER UNIVERSITY Sessional Instructor Position ­ Spring 2016 REM 471: Forest Ecosystem Management Applications are invited for one-term sessional Ecosystem Management. Course description: Forest ecosystem management is a complex, multi

  10. innovation.asu.edu air transportation management

    E-Print Network [OSTI]

    innovation.asu.edu air transportation management aeronautical management technology the polytechnic school #12;undergraduate degree program B.S., aeronautical management technology, concentration in air in Aeronautical Management Technology, provides students with a strong foundation of aviation concepts, including

  11. AVLIS production plant waste management plan

    SciTech Connect (OSTI)

    Not Available

    1984-11-15

    Following the executive summary, this document contains the following: (1) waste management facilities design objectives; (2) AVLIS production plant wastes; (3) waste management design criteria; (4) waste management plan description; and (5) waste management plan implementation. 17 figures, 18 tables.

  12. DOE Releases Electricity Subsector Cybersecurity Risk Management...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Releases Electricity Subsector Cybersecurity Risk Management Process (RMP) Guideline DOE Releases Electricity Subsector Cybersecurity Risk Management Process (RMP) Guideline May...

  13. EM Hosts Contract Performance and Management Workshop

    Broader source: Energy.gov [DOE]

    WASHINGTON, D.C. – EM hosted the Environmental Management Contract Performance and Management Workshop at DOE headquarters Wednesday.

  14. Risk Management in Biopharmaceutical Supply Chains

    E-Print Network [OSTI]

    Ma, Yao

    2011-01-01

    Supply Chain Risk Managementof Recent Work on Supply Chain Risk Management . . . . .M. , Supply chain risk management: Outlining an agenda for

  15. Building International Emergency Management Systems | National...

    National Nuclear Security Administration (NNSA)

    Building International Emergency Management Systems | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing...

  16. Miamisburg Environmental Management Project Archived Soil & Groundwate...

    Office of Environmental Management (EM)

    Miamisburg Environmental Management Project Archived Soil & Groundwater Master Reports Miamisburg Environmental Management Project Archived Soil & Groundwater Master Reports...

  17. Fernald Environmental Management Project Archived Soil & Groundwater...

    Office of Environmental Management (EM)

    Fernald Environmental Management Project Archived Soil & Groundwater Master Reports Fernald Environmental Management Project Archived Soil & Groundwater Master Reports Fernald...

  18. DOE Challenge Home Recommended Quality Management Provisions

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Recommended Quality Management Provisions RECOMMENDED QUALITY MANAGEMENT PROVISIONS QM Provision Builder Documentation & Verification Requirements RaterVerifier Requirements QM...

  19. Material Management and Minimization | National Nuclear Security...

    National Nuclear Security Administration (NNSA)

    Management and Minimization | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation Powering...

  20. Consequence Management | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Consequence Management | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation Powering the...

  1. Waste shipment engineering data management plan

    SciTech Connect (OSTI)

    Marquez, D.L.

    1995-05-01

    This plan documents current data management practices and future data management improvements for TWRS Waste Shipment Engineering.

  2. GARS ESH Management Review GARS Research Operations

    E-Print Network [OSTI]

    Ohta, Shigemi

    on the presentation content Senior Managers shall comment on the need for change or improvement. #12;GARS FY13 ESHGARS ESH Management Review GARS Research Operations December 11, 2013 #12;GARS FY13 ESH Management Review ­ Slide 2 Management Review Scope Senior Management shall review the EMS and OSH Management

  3. FACULTY OF MANAGEMENT Minor: Social Responsibility

    E-Print Network [OSTI]

    Seldin, Jonathan P.

    in Canada Management 4390 - Leading Organizational Change Management 4580 - Environmental Management One ofFACULTY OF MANAGEMENT Minor: Social Responsibility A minor in Social Responsibility is available as an adjunct to all majors in the Bachelor of Management degree, Post-Diploma Bachelor of Management degree

  4. Storage management solutions Buyer's guide: purchasing criteria

    E-Print Network [OSTI]

    levels, reflect best practices and deliver measurable business results. #12;22 Manage changes to your: · Change process management · Incident management · Configuration management · Compliance management #12 a formal change management process. Take control of unexpected incidents While most businesses use a mix

  5. Engineering Radio resource management for OFDMA systems under practical

    E-Print Network [OSTI]

    Martin, Ralph R.

    in the construction industry / Bin Chen. Ph.D. 2009 NF nanofiltration membrane characterization / Ahmed Saleh Al verification / Neil Pearson. M.Phil. 2008 #12; Design and optimisation of joints in a carbon fibre bicycle reservoir 'A' / Hussain Al-Hassani. M.Res. 2008 Chemical Engineering Tensile properties of polymeric

  6. Stage Management & Technology 

    E-Print Network [OSTI]

    O'Brien, Madison D

    2013-02-04

    , this information is usually e-mailed out in addition to being posted in hardcopy form. The prompt book, often known as the bible of the show, is a crucial tool. It contains all the information a stage manager, substitute, or assistant would need to know... for editing documents, but they are good for quick reference. Importing documents to these e-reader applications also has to be done over iTunes or for Kindle over amazon.com or iTunes. A document that is attached to an e-mail can be opened and saved in i...

  7. Environmental management system.

    SciTech Connect (OSTI)

    Salinas, Stephanie A.

    2010-08-01

    The purpose of the Sandia National Laboratories/New Mexico (SNL/NM) Environmental Management System (EMS) is identification of environmental consequences from SNL/NM activities, products, and/or services to develop objectives and measurable targets for mitigation of any potential impacts to the environment. This Source Document discusses the annual EMS process for analysis of environmental aspects and impacts and also provides the fiscal year (FY) 2010 analysis. Further information on the EMS structure, processes, and procedures are described within the programmatic EMS Manual (PG470222).

  8. Measuring Process Safety Management

    SciTech Connect (OSTI)

    Sweeney, J.C. (ARCO Chemical Co., Newtown Square, PA (United States))

    1992-04-01

    Many companies are developing and implementing Process Safety Management (PSM) systems. Various PSM models, including those by the Center for Chemical Process Safety (CCPS), the American Petroleum Institute (API), the Chemical Manufacturers Association (CMA) and OSHA have emerged to guide the design, development and installation of these systems. These models represent distillations of the practices, methods and procedures successfully used by those who believed that a strong correlation exists between sound PSM practices and achieving reductions in the frequency and severity of process incidents. This paper describes the progress of CCPS research toward developing a PSM performance measurement model. It also provides a vision for future CCPS research to define effectiveness indices.

  9. Real Property Asset Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-09-24

    The directive establishes an integrated corporate-level, performance based approach to the life-cycle management of our real property assets. It links real property asset planning, programming, budgeting and evaluation to the Department's multi-faceted missions. Successful implementation of this order will enable the Department to carry out our stewardship responsibilities, and will ensure that our facilities and infrastructure are properly sized and in a condition to meet our mission requirements today and in the future. Chg 1, dated 2-8-08. Chg 2, dated 4-25-11

  10. Real Property Asset Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-09-24

    The directive establishes an integrated corporate-level, performance based approach to the life-cycle management of our real property assets. It links real property asset planning, programming, budgeting and evaluation to the Department's multi-faceted missions. Successful implementation of this order will enable the Department to carry out our stewardship responsibilities, and will ensure that our facilities and infrastructure are properly sized and in a condition to meet our mission requirements today and in the future. Cancels: DOE O 430.1A. Chg 1, dated 2-8-08. Chg 2, dated 4-25-11

  11. Information Management Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    Provides a framework for managing information, information resources, and information technology investment, which supports the operating elements of the Department in the accomplishment of its missions and functions in both an efficient and effective manner and in accordance with Departmental policy. Cancels: DOE 1324.5B, DOE 5900.1A, DOE 1130.8A, DOE 1330.1D, DOE 1410.2, DOE 1450.3A, DOE 1700.1, DOE 1800.1A, DOE 5300.1C

  12. Plutonium Vulnerability Management Plan

    SciTech Connect (OSTI)

    1995-03-01

    This Plutonium Vulnerability Management Plan describes the Department of Energy`s response to the vulnerabilities identified in the Plutonium Working Group Report which are a result of the cessation of nuclear weapons production. The responses contained in this document are only part of an overall, coordinated approach designed to enable the Department to accelerate conversion of all nuclear materials, including plutonium, to forms suitable for safe, interim storage. The overall actions being taken are discussed in detail in the Department`s Implementation Plan in response to the Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1. This is included as Attachment B.

  13. Power management system

    DOE Patents [OSTI]

    Algrain, Marcelo C. (Peoria, IL); Johnson, Kris W. (Washington, IL); Akasam, Sivaprasad (Peoria, IL); Hoff, Brian D. (East Peoria, IL)

    2007-10-02

    A method of managing power resources for an electrical system of a vehicle may include identifying enabled power sources from among a plurality of power sources in electrical communication with the electrical system and calculating a threshold power value for the enabled power sources. A total power load placed on the electrical system by one or more power consumers may be measured. If the total power load exceeds the threshold power value, then a determination may be made as to whether one or more additional power sources is available from among the plurality of power sources. At least one of the one or more additional power sources may be enabled, if available.

  14. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergy comparingDeep Vadose ZonePerformanceManagement

  15. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergy comparingDeep Vadose Management Performance

  16. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergy comparingDeep Vadose Management Performance

  17. Contract/Project Management

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergy comparingDeep Vadose Management Performance

  18. NERSC Data Management Policies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJessework usesof Energy Moving ForwardAchievementScienceData Management

  19. Management Rachana Ananthakrishnan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousandReport)Price (Dollars perManagement Council EmilioGlobus for

  20. Wildlife management assistance report

    SciTech Connect (OSTI)

    Caudell, M.B.

    1992-05-01

    Thirty-four days were spent administering hunts on Crackerneck Wildlife Management Area with 1773 people participating. Biological data was collected on 76 deer, eight wild turkeys, 33 feral hogs, 58 ducks of two species, 75 gray squirrels, 4 raccoons, 9 bobwhites, and 484 fish of 9 species. Serving as a Coordinating Land User for the SRS Site Use Committee entailed evaluating 81 land use proposals with regard to effects on wildlife populations. The antlerless deer quota program continued in the district with 129 landowners in Aiken, Barnwell, and Orangeburg Counties being approved for antlerless harvest which required field investigations, acreage verification at tax offices, and personal correspondence. Bait sites for turkey trapping were maintained on the SRS for two months. Wildlife census work was conducted on wild turkey, bobwhite, mourning dove, furbearers, fox squirrels, and bald eagles on the SRS and in Aiken and Barnwell Counties. Three wetlands in Aiken County were evaluated for suitability with regard to wood duck boxes. Two wetland environmental review notices for the SRS were evaluated. Additional work on Wildlife Management Area land included reposting 50 miles of boundary in Aiken and Lexington County and removing signs form several tracts lost from the program. Future recommendations for the turkey and regulations brochures were submitted and WMA maps covering Aiken and Lexington Counties were updated.

  1. (Managing the global environment)

    SciTech Connect (OSTI)

    Rayner, S.F.

    1989-10-03

    The conference was stimulated by concern that policy makers increasingly have to make environmental management decisions in the absence of solidly established scientific consensus about ecological processes and the consequences of human actions. Often, as in the case of climate change, some decisions may have to be made in the absence of information that is desirable but may not be available for years to come, if ever. Six topics were identified as running throughout the Congress. These were: the epistemology and history of the sciences or disciplines concerned with the environment, including the scientific basis of rationality and modes of dealing with uncertainty and complexity; the social, economic, and institutional conditions for the production of knowledge bearing on the environment, including the politics of research and the improvement of scientific data; the structuring and institutionalization of expert assessments on national and international levels, including the global distribution of expertise; the means of establishing scientific information, the role of the media in transmitting and processing knowledge about the environment, and the organization of public environmental debate; and decision making and management under conditions of uncertainty; and, finally the relationship between science and ethics. 13 refs.

  2. Cryptographic Key Management System

    SciTech Connect (OSTI)

    No, author

    2014-02-21

    This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene#12;ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

  3. Training Management Information System

    SciTech Connect (OSTI)

    Rackley, M.P.

    1989-01-01

    The Training Management Information System (TMIS) is an integrated information system for all training related activities. TMIS is at the leading edge of training information systems used in the nuclear industry. The database contains all the necessary records to confirm the department's adherence to accreditation criteria and houses all test questions, student records and information needed to evaluate the training process. The key to the TMIS system is that the impact of any change (i.e., procedure change, new equipment, safety incident in the commercial nuclear industry, etc.) can be tracked throughout the training process. This ensures the best training can be performed that meets the needs of the employees. TMIS is comprised of six functional areas: Job and Task Analysis, Training Materials Design and Development, Exam Management, Student Records/Scheduling, Evaluation, and Commitment Tracking. The system consists of a VAX 6320 Cluster with IBM and MacIntosh computers tied into an ethernet with the VAX. Other peripherals are also tied into the system: Exam Generation Stations to include mark sense readers for test grading, Production PC's for Desk-Top Publishing of Training Material, and PC Image Workstations. 5 figs.

  4. Shopping for outage management systems

    SciTech Connect (OSTI)

    Chou, Y.C.; Konneker, L.K.; Watkins, T.R.

    1995-12-31

    Customer service is becoming increasingly important to electric utilities. Outage management is an important part of customer service. Good outage management means quickly responding to outages and keeping customers informed about outages. Each outage equals lost customer satisfaction and lost revenue. Outage management is increasingly important because of new competition among utilities for customers, pressure from regulators, and internal pressure to cut costs. The market has several existing software products for outage management. How does a utility judge whether these products satisfy their specific needs? Technology is changing rapidly to support outage management. Which technology is proven and cost-effective? The purpose of this paper is to outline the procedure for evaluating outage management systems, and to discuss the key features to look for. It also gives our opinion of the features that represent state of the art. This paper will not discuss specific products or list vendors names.

  5. FLUOR HANFORD SAFETY MANAGEMENT PROGRAMS

    SciTech Connect (OSTI)

    GARVIN, L J; JENSEN, M A

    2004-04-13

    This document summarizes safety management programs used within the scope of the ''Project Hanford Management Contract''. The document has been developed to meet the format and content requirements of DOE-STD-3009-94, ''Preparation Guide for US. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses''. This document provides summary descriptions of Fluor Hanford safety management programs, which Fluor Hanford nuclear facilities may reference and incorporate into their safety basis when producing facility- or activity-specific documented safety analyses (DSA). Facility- or activity-specific DSAs will identify any variances to the safety management programs described in this document and any specific attributes of these safety management programs that are important for controlling potentially hazardous conditions. In addition, facility- or activity-specific DSAs may identify unique additions to the safety management programs that are needed to control potentially hazardous conditions.

  6. Human factors in waste management

    SciTech Connect (OSTI)

    Moray, N.

    1994-10-01

    This article examines the role of human factors in radioactive waste management. Although few problems and ergonomics are special to radioactive waste management, some problems are unique especially with long term storage. The entire sociotechnical system must be looked at in order to see where improvement can take place because operator errors, as seen in Chernobyl and Bhopal, are ultimately the result of management errors.

  7. Accident management for severe accidents

    SciTech Connect (OSTI)

    Bari, R.A.; Pratt, W.T.; Lehner, J.; Leonard, M.; Disalvo, R.; Sheron, B.

    1988-01-01

    The management of severe accidents in light water reactors is receiving much attention in several countries. The reduction of risk by measures and/or actions that would affect the behavior of a severe accident is discussed. The research program that is being conducted by the US Nuclear Regulatory Commission focuses on both in-vessel accident management and containment and release accident management. The key issues and approaches taken in this program are summarized. 6 refs.

  8. NISTIR 8023 Risk Management for

    E-Print Network [OSTI]

    with replication devices. Keywords 3D printers; 3D scanners; copiers; countermeasures; exploits; mitigation; multifunction devices; printers; replication devices; risk; risk assessment; risk management; scanners; security

  9. Thermal Management of Solar Cells

    E-Print Network [OSTI]

    Saadah, Mohammed Ahmed

    2013-01-01

    cell. The solar cell’s power conversion efficiency, ? is theEfficiency ..5 Thermal Managements of SolarTemperature on Efficiency Photons incident on a solar cell

  10. Section 10: Risk Management Concepts

    E-Print Network [OSTI]

    2014-12-04

    Dec 2, 2014 ... In this lesson we will discuss some concepts from risk management and insurance. We will go over the basic definitions and discuss some ...

  11. FAQS Reference Guide – Construction Management

    Broader source: Energy.gov [DOE]

    This reference guide addresses the competency statements in the March 2004 edition of DOE-STD-1180-2004, Construction Management Functional Area Qualification Standard.

  12. Portfolio Manager Space Type Discussion

    Broader source: Energy.gov [DOE]

    This presentation, given through the DOE's Technical Assistance Program (TAP), provides a discussion about space/type in regards to the Portfolio Manager Initiative.

  13. Site Manager Pantex Site Office

    National Nuclear Security Administration (NNSA)

    workforce. These re- ports serve the purpose of assisting management in workforce planning aligned to our strategic goals. Additionally, the reports help us analyze our...

  14. Analysis of Cluster Management Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Analysis of Configuration Management Tools Computer System, Cluster, and Networking Summer Institute Team: Evan Leeseberg, James Kang, Katherine Nystrom Mentors: Kevin Tegtmeier,...

  15. Hazardous Waste Management (New Mexico)

    Broader source: Energy.gov [DOE]

    The New Mexico Environment Department's Hazardous Waste Bureau is responsible for the management of hazardous waste in the state. The Bureau enforces the rules established by the Environmental...

  16. Solid Waste Management (North Carolina)

    Broader source: Energy.gov [DOE]

    The Solid Waste Program regulates safe management of solid waste through guidance, technical assistance, regulations, permitting, environmental monitoring, compliance evaluation and enforcement....

  17. Solid Waste Management (South Dakota)

    Broader source: Energy.gov [DOE]

    This statute contains provisions for solid waste management systems, groundwater monitoring, liability for pollution, permitting, inspections, and provisions for waste reduction and recycling...

  18. FAQS Reference Guide – Emergency Management

    Office of Energy Efficiency and Renewable Energy (EERE)

    This reference guide addresses the competency statements in the January 2004 edition of DOE-STD-1177-2004, Emergency Management Functional Area Qualification Standard.

  19. Thermal Management of Solar Cells

    E-Print Network [OSTI]

    Saadah, Mohammed Ahmed

    2013-01-01

    phonon transmission and interface thermal conductance acrossF. Miao, et al. , "Superior Thermal Conductivity of Single-Advanced Materials for Thermal Management of Electronic

  20. Managers spur productivity gains. [USA

    SciTech Connect (OSTI)

    Brezovec, D.

    1981-12-01

    Output per worker hour grows at U.S. coal mines as management gears training programs and operating practices to fight falling productivity.

  1. Scientific and Technical Information Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-10-14

    The Order establishes requirements and responsibilities for managing DOE's scientific and technical information. Cancels DOE O 241.1. Canceled by DOE O 241.1B.

  2. COURSE SYLLABUS ENVIRONMENTAL NUTRIENT MANAGEMENT

    E-Print Network [OSTI]

    Ma, Lena

    1 COURSE SYLLABUS ENVIRONMENTAL NUTRIENT MANAGEMENT SWS 4116 / 5115 3 Credits 2102 McCarty Hall. UNIVERSITY POLICIES A. STUDENTS REQUIRING SPECIAL ASSISTANCE: Students requesting classroom accommodations

  3. Portfolio Manager Space Type Discussion

    Broader source: Energy.gov [DOE]

    This presentation, given through the DOE's Technical Assitance Program (TAP), provides a discussion about space/type in regards to the Portfolio Manager Initiative.

  4. GE Energy Management Ancillary Services

    E-Print Network [OSTI]

    GE Energy Management Ancillary Services Definitions and Capability Study Part 2, Tasks 3-4, Final Online Wind Plants & Frequency Responsive Load Reserves

  5. Government Personal Property Asset Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1998-05-11

    Establishes procedures for managing Government personal property owned or leased by and in the custody of Department of Energy (DOE) Headquarters employees. Cancels HQ 1400.1.

  6. ISO 50001 Energy Management Standard

    SciTech Connect (OSTI)

    2013-08-12

    This powerful standard from the International Organization for Standardization (ISO) provides an internationally recognized framework for organizations to voluntarily implement an energy management system.

  7. Earned Value Management System (EVMS)

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-03-13

    This Guide provides approaches for implementing the Earned Value Management System (EVMS) requirements of DOE O 413.3B. Supersedes DOE G 413.3-10.

  8. Growth management and sustainable transport: Do growth management policies promote transit use? 

    E-Print Network [OSTI]

    Deal, Brian; Kim, Jae H; Chackraborty, Arnab

    2009-01-01

    4). Figure 4. Sustainable Growth Management and TransportIntegration Growth Management and Sustainable Transport2004. Do state growth management regulations reduce sprawl?

  9. Evaluating Ocean Management Systems to Facilitate the Development of Ecosystem-Based Management

    E-Print Network [OSTI]

    Young, Oran R

    2009-01-01

    ENV-02 Evaluating Ocean Management Systems to Facilitate theof Ecosystem-Based Management Preparer Information: Juliaof Environmental Science & Management young@bren.ucsb.edu

  10. The Landscape Manage-ment System (LMS) is a

    E-Print Network [OSTI]

    Brown, Sally

    to unanticipated and vexing natural resource manage- ment problems that impact rural communities is right down our technology to unanticipated and vexing natural resource management problems that impact rural communities) to test the applicability of LMS to DNR planning needs. Partly through this proc- ess, community leaders

  11. Kodiak Area Management Reports, 19242010 Kodiak Area Management Reports, 19242010

    E-Print Network [OSTI]

    367 Kodiak Area Management Reports, 1924­2010 APPENDIX 4 Kodiak Area Management Reports, 1924­2010 1924: Fred R. Lucas. Report of Kodiak-Afognak Fish- eries District to August 31, 1924. U.S. Bureau of Fisheries, Afognak, AK (5 September 1924). 8 p. 1924: Fred R. Lucas. Report of Kodiak-Afognak Dis- trict

  12. Information Technology and Management Department of Information Technology and Management

    E-Print Network [OSTI]

    in the information technology and cyber security fields. The Information Technology and Management degrees apply- riculum to give cyber security and forensics practitioners a thorough grounding in legal issues Forensics and Security Certificate Programs Advanced Software Development Cyber Security Management Cyber

  13. Archives & Records Management Bulletin UW-Madison Records Management Program

    E-Print Network [OSTI]

    Sheridan, Jennifer

    , maintain, dispose of, and preserve university records. This bulletin outlines records management, management, and distribution of information are at the heart of what the University is all about. Knowledge, examine critically, preserve and transmit the knowledge, wisdom and values that will help ensure

  14. Computerized training management system

    DOE Patents [OSTI]

    Rice, Harold B. (Franklin Furnace, OH); McNair, Robert C. (East Setauket, NY); White, Kenneth (Shirley, NY); Maugeri, Terry (Wading River, NY)

    1998-08-04

    A Computerized Training Management System (CTMS) for providing a procedurally defined process that is employed to develop accreditable performance based training programs for job classifications that are sensitive to documented regulations and technical information. CTMS is a database that links information needed to maintain a five-phase approach to training-analysis, design, development, implementation, and evaluation independent of training program design. CTMS is designed using R-Base.RTM., an-SQL compliant software platform. Information is logically entered and linked in CTMS. Each task is linked directly to a performance objective, which, in turn, is linked directly to a learning objective; then, each enabling objective is linked to its respective test items. In addition, tasks, performance objectives, enabling objectives, and test items are linked to their associated reference documents. CTMS keeps all information up to date since it automatically sorts, files and links all data; CTMS includes key word and reference document searches.

  15. Computerized training management system

    DOE Patents [OSTI]

    Rice, H.B.; McNair, R.C.; White, K.; Maugeri, T.

    1998-08-04

    A Computerized Training Management System (CTMS) is disclosed for providing a procedurally defined process that is employed to develop accreditable performance based training programs for job classifications that are sensitive to documented regulations and technical information. CTMS is a database that links information needed to maintain a five-phase approach to training-analysis, design, development, implementation, and evaluation independent of training program design. CTMS is designed using R-Base{trademark}, an-SQL compliant software platform. Information is logically entered and linked in CTMS. Each task is linked directly to a performance objective, which, in turn, is linked directly to a learning objective; then, each enabling objective is linked to its respective test items. In addition, tasks, performance objectives, enabling objectives, and test items are linked to their associated reference documents. CTMS keeps all information up to date since it automatically sorts, files and links all data; CTMS includes key word and reference document searches. 18 figs.

  16. Technical Management for Buildings

    E-Print Network [OSTI]

    Vairo, Antonio

    1999-01-01

    This paper is a presentation of an 'instrument' for the optimization of the functionality and conservation of tertiary buildings. This technique has several different names: Building Automation Systems (BAS), Central Control and Monitoring System (CCMS) in English, and Gestion Technique du Bâtiment' (GTB) or Gestion Technique Centralisée (GTC) in French. With this technique it is possible to manage all the functions of a building, it is a modern instrument that introduces the concept of 'automation' in the operation of buildings using computerized procedures, earlier reserved for industrial processes. The system is structured with different automation levels with a distributed intelligence, each level characterized by a communication system (Fieldbus for the lowest and Ethernet for the highest level). In order to apply the BAS to CERN buildings it is necessary to evaluate the advantages, the CERN requirements and the integration with the several existing control and automation systems.

  17. Master of Science in Engineering and Technology Management Engineering Management Concentration Management of Technology Concentration

    E-Print Network [OSTI]

    Selmic, Sandra

    ELEN 527 Optical Communication Systems INEN 516 Production Planning Production Planning and Sequencing Control MGMT 510 Contemporary Management ENTR 501 Technology Transfer

  18. Strategic Plan Information Resources Management

    E-Print Network [OSTI]

    Rock, Chris

    Resources Management Organizations, Policies, and Practices 12 Priorities 12 Planning 12 Quality AssuranceStrategic Plan for Information Resources Management For the Fiscal Years 2003-2007 Period by Texas Operations 14 Standards 15 Organization 15 Computer Networks 15 2 #12;Introduction & Summary Committed

  19. ENERGY MANAGEMENT OPERATIONAL PROCEDURE MANUAL

    E-Print Network [OSTI]

    Harman, Neal.A.

    ENERGY MANAGEMENT OPERATIONAL PROCEDURE MANUAL Swansea University Estates Services Singleton Park Swansea SA2 8PP Tel 01792 295819 Fax 01792 295820 #12;Swansea University Energy Management Operational Procedural Manual Estates Services April 2008 rev 1 Created on 4/15/2008 4:23:00 PM - 2 - Contents 1. Energy

  20. FOREST INVENTORY Managing Forest Ecosystems

    E-Print Network [OSTI]

    #12;FOREST INVENTORY #12;Managing Forest Ecosystems Volume 10 Series Editors: Klaus von Gadow Georg Superior de Agronomía, Lisbon, Portugal Aims & Scope: Well-managed forests and woodlands are a renewable resource, producing essential raw material with minimum waste and energy use. Rich in habitat and species