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Sample records for mam links nems

  1. Macroeconomic Activity Module - NEMS Documentation

    Reports and Publications (EIA)

    2016-01-01

    Documents the objectives, analytical approach, and development of the National Energy Modeling System (NEMS) Macroeconomic Activity Module (MAM) used to develop the Annual Energy Outlook for 2016 (AEO2016). The report catalogues and describes the module assumptions, computations, methodology, parameter estimation techniques, and mainframe source code

  2. Macroeconomic Activity Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Documents the objectives, analytical approach, and development of the National Energy Modeling System (NEMS) Macroeconomic Activity Module (MAM) used to develop the Annual Energy Outlook for 2014 (AEO2014). The report catalogues and describes the module assumptions, computations, methodology, parameter estimation techniques, and mainframe source code

  3. Model developer`s appendix to the model documentation report: NEMS macroeconomic activity module

    SciTech Connect (OSTI)

    1994-07-15

    The NEMS Macroeconomic Activity Module (MAM) tested here was used to generate the Annual Energy Outlook 1994 (AEO94). MAM is a response surface model, not a structural model, composed of three submodules: the National Submodule, the Interindustry Submodule, and the Regional Submodule. Contents of this report are as follows: properties of the mathematical solution; NEMS MAM empirical basis; and scenario analysis. Scenario analysis covers: expectations for scenario analysis; historical world oil price scenario; AEO94 high world oil price scenario; AEO94 low world oil price scenario; and immediate increase world oil price scenario.

  4. Integrating Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Provides an overview of the complete National Energy Modeling System (NEMS) model, and includes brief descriptions of the modules with which the Integrating Module interacts. The emphasis and focus, however, is on the structure and function of the Integrating Module of NEMS.

  5. NEMS International Energy Module

    Gasoline and Diesel Fuel Update (EIA)

    EIA NEMS International Energy Module Model Documentation Report vii Mr. G. Daniel Butler U.S. Department of Energy EI-812 1000 Independence Ave., SW Washington, DC 20585 Tel:...

  6. International Energy Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Summarizes the overall structure of the International Energy Model and its interface with other NEMS modules, mathematical specifications of behavioral relationships, and data sources and estimation methods.

  7. Model documentation report: Macroeconomic Activity Module (MAM) of the National Energy Modeling System

    SciTech Connect (OSTI)

    Not Available

    1994-02-07

    This report documents the objectives, analytical approach, and development of the National Energy Modeling System (NEMS) Macroeconomic Activity Module (MAM) used to develop the Annual Energy Outlook for 1994 (AEO94). The report catalogues and describes the module assumptions, computations, methodology, parameter estimation techniques, and mainframe source code. This document serves three purposes. First, it is a reference document providing a detailed description of the NEMS MAM used for the AEO 1994 production runs for model analysts, users, and the public. Second, this report meets the legal requirement of the Energy Information Administration (EIA) to provide adequate documentation in support of its models (Public Law 94-385, section 57.b.2). Third, it facilitates continuity in model development by providing documentation from which energy analysts can undertake model enhancements, data updates, and parameter refinements as future projects.

  8. Model Documentation Report: Macroeconomic Activity Module (MAM) of the National Energy Modeling System

    U.S. Energy Information Administration (EIA) Indexed Site

    Model Documentation Report: Macroeconomic Activity Module (MAM) of the National Energy Modeling System May 2014 Independent Statistics & Analysis www.eia.gov U.S. Department of Energy Washington, DC 20585 U.S. Energy Information Administration | NEMS Macroeconomic Activity Module Documentation Report i This report was prepared by the U.S. Energy Information Administration (EIA), the statistical and analytical agency within the U.S. Department of Energy. By law, EIA's data, analyses, and

  9. Renewable Fuels Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    This report documents the objectives, analytical approach, and design of the National Energy Modeling System (NEMS) Renewable Fuels Module (RFM) as it relates to the production of the Annual Energy Outlook forecasts.

  10. Residential Demand Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Model Documentation - Documents the objectives, analytical approach, and development of the National Energy Modeling System (NEMS) Residential Sector Demand Module. The report catalogues and describes the model assumptions, computational methodology, parameter estimation techniques, and FORTRAN source code.

  11. Industrial Demand Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Documents the objectives, analytical approach, and development of the National Energy Modeling System (NEMS) Industrial Demand Module. The report catalogues and describes model assumptions, computational methodology, parameter estimation techniques, and model source code.

  12. Transportation Sector Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Documents the objectives, analytical approach and development of the National Energy Modeling System (NEMS) Transportation Model (TRAN). The report catalogues and describes the model assumptions, computational methodology, parameter estimation techniques, model source code, and forecast results generated by the model.

  13. National Energy Modeling System (NEMS)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The National Energy Modeling System (NEMS) is a computer-based, energy-economy modeling system of U.S. through 2030. NEMS projects the production, imports, conversion, consumption, and prices of energy, subject to assumptions on macroeconomic and financial factors, world energy markets, resource availability and costs, behavioral and technological choice criteria, cost and performance characteristics of energy technologies, and demographics. NEMS was designed and implemented by the Energy Information Administration (EIA) of the U.S. Department of Energy (DOE). NEMS can be used to analyze the effects of existing and proposed government laws and regulations related to energy production and use; the potential impact of new and advanced energy production, conversion, and consumption technologies; the impact and cost of greenhouse gas control; the impact of increased use of renewable energy sources; and the potential savings from increased efficiency of energy use; and the impact of regulations on the use of alternative or reformulated fuels. NEMS has also been used for a number of special analyses at the request of the Administration, U.S. Congress, other offices of DOE and other government agencies, who specify the scenarios and assumptions for the analysis. Modules allow analyses to be conducted in energy topic areas such as residential demand, industrial demand, electricity market, oil and gas supply, renewable fuels, etc.

  14. NEMS integrating module documentation report

    SciTech Connect (OSTI)

    Not Available

    1993-12-14

    The National Energy Modeling System (NEMS) is a computer modeling system that produces a general equilibrium solution for energy supply and demand in the US energy markets. The model achieves a supply and demand balance in the end-use demand regions, defined as the nine Census Divisions, by solving for the prices of each energy type such that the quantities producers are willing to supply equal the quantities consumers wish to consume. The system reflects market economics, industry structure, and energy policies and regulations that influence market behavior. The NEMS Integrating Module is the central integrating component of a complex modeling system. As such, a thorough understanding of its role in the modeling process can only be achieved by placing it in the proper context with respect to the other modules. To that end, this document provides an overview of the complete NEMS model, and includes brief descriptions of the modules with which the Integrating Module interacts. The emphasis and focus, however, is on the structure and function of the Integrating Module of NEMS.

  15. Commercial Demand Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Documents the objectives, analytical approach and development of the National Energy Modeling System (NEMS) Commercial Sector Demand Module. The report catalogues and describes the model assumptions, computational methodology, parameter estimation techniques, model source code, and forecast results generated through the synthesis and scenario development based on these components.

  16. Coal Market Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Documents the objectives and the conceptual and methodological approach used in the development of the National Energy Modeling System's (NEMS) Coal Market Module (CMM) used to develop the Annual Energy Outlook 2014 (AEO2014). This report catalogues and describes the assumptions, methodology, estimation techniques, and source code of CMM's two submodules. These are the Coal Production Submodule (CPS) and the Coal Distribution Submodule (CDS).

  17. NEMS - National Energy Modeling System: An Overview

    Reports and Publications (EIA)

    2009-01-01

    The National Energy Modeling System: An Overview 2009 a summary description of NEMS and each of its components. NEMS is a computer-based, energy-economy modeling system of energy markets for the midterm period through 2030. The NEMS is used to produce the Annual Energy Outlook.

  18. nem_spread Ver. 5.10

    Energy Science and Technology Software Center (OSTI)

    2009-06-08

    Nem_spread reads it's input command file (default name nem_spread.inp), takes the named ExodusII geometry definition and spreads out the geometry (and optionally results) contained in that file out to a parallel disk system. The decomposition is taken from a scalar Nemesis load balance file generated by the companion utility nem_slice.

  19. NEMS Modeling of Coal Plants

    U.S. Energy Information Administration (EIA) Indexed Site

    NEMS Modeling of Coal Plants Office of Electricity, Coal, Nuclear, and Renewable Analysis Laura Martin June 14, 2016 Washington, DC 2 EMM Structure EFD ECP EFP ELD Laura Martin Washington, DC, June 14, 2016 Electricity Load and Demand Submodule Liquid Fuels Market Module Model inputs for coal plants 3 * Existing coal plants - plant specific inputs - Fixed and variable operating and maintenance costs, annual capital additions - Retrofit costs (capital and O&M) - FGD, DSI, SCR, SNCR, CCS, FF -

  20. Model Documentation Report: Macroeconomic Activity Module (MAM...

    Gasoline and Diesel Fuel Update (EIA)

    Gross State Product The MAM projects regional gross regional product in real per capita terms. The equations are in log form. There is an estimated equation for each of the nine...

  1. NEMS Freight Transportation Module Improvement Study

    U.S. Energy Information Administration (EIA) Indexed Site

    NEMS Freight Transportation Module Improvement Study February 2015 Independent Statistics & Analysis www.eia.gov U.S. Department of Energy Washington, DC 20585 U.S. Energy Information Administration | NEMS Freight Transportation Module Improvement Study i This report was prepared by the U.S. Energy Information Administration (EIA), the statistical and analytical agency within the U.S. Department of Energy. By law, EIA's data, analyses, and forecasts are independent of approval by any other

  2. nem_slice ver. 3.34

    Energy Science and Technology Software Center (OSTI)

    2009-06-08

    Nem_slice reads in a finite element model description of the geometry of a problem from an ExodusII file and generates either a nodal or elemental graph of the problem. It then calls Chaco to load balance the graph and then outputs a NemesisI load-balance file.

  3. Integrated NEMS and optoelectronics for sensor applications.

    SciTech Connect (OSTI)

    Czaplewski, David A.; Serkland, Darwin Keith; Olsson, Roy H., III; Bogart, Gregory R. (Symphony Acoustics, Rio Rancho, NM); Krishnamoorthy, Uma; Warren, Mial E.; Carr, Dustin Wade (Symphony Acoustics, Rio Rancho, NM); Okandan, Murat; Peterson, Kenneth Allen

    2008-01-01

    This work utilized advanced engineering in several fields to find solutions to the challenges presented by the integration of MEMS/NEMS with optoelectronics to realize a compact sensor system, comprised of a microfabricated sensor, VCSEL, and photodiode. By utilizing microfabrication techniques in the realization of the MEMS/NEMS component, the VCSEL and the photodiode, the system would be small in size and require less power than a macro-sized component. The work focused on two technologies, accelerometers and microphones, leveraged from other LDRD programs. The first technology was the nano-g accelerometer using a nanophotonic motion detection system (67023). This accelerometer had measured sensitivity of approximately 10 nano-g. The Integrated NEMS and optoelectronics LDRD supported the nano-g accelerometer LDRD by providing advanced designs for the accelerometers, packaging, and a detection scheme to encapsulate the accelerometer, furthering the testing capabilities beyond bench-top tests. A fully packaged and tested die was never realized, but significant packaging issues were addressed and many resolved. The second technology supported by this work was the ultrasensitive directional microphone arrays for military operations in urban terrain and future combat systems (93518). This application utilized a diffraction-based sensing technique with different optical component placement and a different detection scheme from the nano-g accelerometer. The Integrated NEMS LDRD supported the microphone array LDRD by providing custom designs, VCSELs, and measurement techniques to accelerometers that were fabricated from the same operational principles as the microphones, but contain proof masses for acceleration transduction. These devices were packaged at the end of the work.

  4. NEMS Buildings Sector Working Group Meeting

    U.S. Energy Information Administration (EIA) Indexed Site

    NEMS Buildings Sector Working Group Meeting Erin Boedecker Owen Comstock Behjat Hojjati Kevin Jarzomski David Peterson Steve Wade October 4, 2012 | Washington, D.C. AEO2013 Preliminary Results WORKING GROUP PRESENTATION FOR DISCUSSION PURPOSES DO NOT QUOTE OR CITE AS RESULTS ARE SUBJECT TO CHANGE WORKING GROUP PRESENTATION FOR DISCUSSION PURPOSES DO NOT QUOTE OR CITE AS RESULTS ARE SUBJECT TO CHANGE Overview Buildings Working Group Forrestal 2E-069 | October 4, 2012 2 * Recap of project list

  5. How to obtain the National Energy Modeling System (NEMS)

    Reports and Publications (EIA)

    2013-01-01

    The National Energy Modeling System (NEMS) NEMS is used by the modelers at the U. S. Energy Information Administration (EIA) who understand its structure and programming. NEMS has only been used by a few organizations outside of the EIA, because most people that requested NEMS found out that it was too difficult or rigid to use. NEMS is not typically used for state-level analysis and is poorly suited for application to other countries. However, many do obtain the model simply to use the data in its input files or to examine the source code.

  6. Frequency Stabilization in Nonlinear MEMS and NEMS Oscillators...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Frequency Stabilization in Nonlinear MEMS and NEMS Oscillators Technology available for licensing: a method to create micro- and nanoscale mechanical oscillators with excellent...

  7. Appendix C: Map of NEMS Electricity Market Module Regions

    Gasoline and Diesel Fuel Update (EIA)

    U.S. Energy Information Administration | Analysis of Impacts of a Clean Energy Standard as requested by Chairman Bingaman Appendix C: Map of NEMS Electricity Market Module Regions

  8. National Energy Modeling System (NEMS) | Open Energy Information

    Open Energy Info (EERE)

    Modeling System (NEMS) AgencyCompany Organization: Energy Information Administration Sector: Energy Focus Area: Economic Development Phase: Develop Goals Topics: Policies...

  9. Overview of NEMS-H2, Version 1.0

    Broader source: Energy.gov (indexed) [DOE]

    production and delivery pathways - Integration of NEMS fuel and electricity supply ... International Energy: Gas Oil Electricity Natural Gas Transmission and Distribution Petroleum ...

  10. Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Useful Links BIOSYNC: Structural Biology Synchrotron Users Organization X-ray Anomalous Scattering Going MAD at CHESS Protein Data Bank Protein Data Bank Search International Union of Crystallography American Crystallographic Association Crystallography 101 Teaching Crystallography Periodic Table Periodic Table and X-ray Properties X-ray data booklet Merohedral crystal twinning server Software Links CCP4 MOSFLM HKL Research, Inc. homepage Solve/Resolve The O-files - Useful reference to the O

  11. Energy Information Administration NEMS Petroleum Market Model...

    Gasoline and Diesel Fuel Update (EIA)

    lignite, and premium), sulfur content (compliancelow, medium, high), and mining type (deep, surface, above ground, underground). These curves are linked to 14 coal demand...

  12. NEMS Freight Transportation Module Improvement Study - Energy Information

    U.S. Energy Information Administration (EIA) Indexed Site

    Administration NEMS Freight Transportation Module Improvement Study Release date: February 3, 2015 The U.S. Energy Information Administration (EIA) contracted with IHS Global, Inc. (IHS) to analyze the relationship between the value of industrial output, physical output, and freight movement in the United States for use in updating analytic assumptions and modeling structure within the National Energy Modeling System (NEMS) freight transportation module, including forecasting methodologies

  13. EIA Buildings Analysis of Consumer Behavior in NEMS

    U.S. Energy Information Administration (EIA) Indexed Site

    Buildings Analysis of Consumer Behavior in NEMS Behavioral Economics Experts Meeting July 17, 2013 | Washington, DC David Peterson Buildings Energy Consumption and Efficiency Analysis Overview Behavioral Economics Experts Meeting, Washington DC, July 17, 2013 2 * NEMS Structure * Housing/floorspace and service demand in Residential Demand Module (RDM) and Commercial Demand Module (CDM) * Market share calculation for equipment in RDM and CDM * Price responses / elasticities * Distributed

  14. Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Links: CAMD's SAXS beamline sister page By Derek Dorman General Reference: Glatter and Kratky Small Angle X-ray Scattering Book (subject to the permission letter and terms of use) SAXS Presentation by Jianhua Li SAXS Presentation by John Pople Dr. Brian Grady's Polymer Characterization Group SAXS page Jun, Y., Waychunas, G. "Molecular-Level Investigations of Nucleation Mechanisms and Kinetics of Formation of Environmental Nanoparticles" Poster SAXS Analysis/Simulation: Paul Scherrer

  15. U.S. Regional Demand Forecasts Using NEMS and GIS

    SciTech Connect (OSTI)

    Cohen, Jesse A.; Edwards, Jennifer L.; Marnay, Chris

    2005-07-01

    The National Energy Modeling System (NEMS) is a multi-sector, integrated model of the U.S. energy system put out by the Department of Energy's Energy Information Administration. NEMS is used to produce the annual 20-year forecast of U.S. energy use aggregated to the nine-region census division level. The research objective was to disaggregate this regional energy forecast to the county level for select forecast years, for use in a more detailed and accurate regional analysis of energy usage across the U.S. The process of disaggregation using a geographic information system (GIS) was researched and a model was created utilizing available population forecasts and climate zone data. The model's primary purpose was to generate an energy demand forecast with greater spatial resolution than what is currently produced by NEMS, and to produce a flexible model that can be used repeatedly as an add-on to NEMS in which detailed analysis can be executed exogenously with results fed back into the NEMS data flow. The methods developed were then applied to the study data to obtain residential and commercial electricity demand forecasts. The model was subjected to comparative and statistical testing to assess predictive accuracy. Forecasts using this model were robust and accurate in slow-growing, temperate regions such as the Midwest and Mountain regions. Interestingly, however, the model performed with less accuracy in the Pacific and Northwest regions of the country where population growth was more active. In the future more refined methods will be necessary to improve the accuracy of these forecasts. The disaggregation method was written into a flexible tool within the ArcGIS environment which enables the user to output the results in five year intervals over the period 2000-2025. In addition, the outputs of this tool were used to develop a time-series simulation showing the temporal changes in electricity forecasts in terms of absolute, per capita, and density of demand.

  16. National Energy Modeling System with Hydrogen Model (NEMS-H2...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Modeling System with Hydrogen Model (NEMS-H2) (OnLocation, Inc. 1 ) Objectives Estimate the energy, economic, and environmental impacts of alternative energy policies and different ...

  17. Appendix A - GPRA06 benefits estimates: MARKAL and NEMS model baseline cases

    SciTech Connect (OSTI)

    None, None

    2009-01-18

    NEMS is an integrated energy model of the U.S. energy system developed by the Energy Information Administration (EIA) for forecasting and policy analysis purposes.

  18. Price Responsiveness in the AEO2003 NEMS Residential and Commercial Buildings Sector Models

    Reports and Publications (EIA)

    2003-01-01

    This paper describes the demand responses to changes in energy prices in the Annual Energy Outlook 2003 versions of the Residential and Commercial Demand Modules of the National Energy Modeling System (NEMS). It updates a similar paper completed for the Annual Energy Outlook 1999 version of the NEMS.

  19. LOCA analysis evaluation model with TRAC-PF1/NEM

    SciTech Connect (OSTI)

    Orive Moreno, Raul; Gallego Cabezon, Ines; Garcia Sedano, Pablo

    2004-07-01

    Nowadays regulatory rules and code models development are progressing on the goal of using best-estimate approximations in applications of license. Inside this framework, IBERDROLA is developing a PWR LOCA Analysis Methodology with one double slope, by a side the development of an Evaluation Model (upper-bounding model) that covers with conservative form the different aspects from the PWR LOCA phenomenology and on the other hand, a proposal of CSAU (Code Scaling Applicability and Uncertainty) type evaluation, methodology that strictly covers the 95/95 criterion in the Peak Cladding Temperature. A structured method is established, that basically involves the following steps: 1. Selection of the Large Break LOCA like accident to analyze and of TRAC-PF1/MOD2 V99.1 NEM (PSU version) computer code like analysis tool. 2. Code Assessment, identifying the most remarkable phenomena (PIRT, Phenomena Identification and Ranking Tabulation) and estimation of a possible code deviation (bias) and uncertainties associated to the specific models that control these phenomena (critical flow mass, heat transfer, countercurrent flow, etc...). 3. Evaluation of an overall PCT uncertainty, taking into account code uncertainty, reactor initial conditions, and accident boundary conditions. Uncertainties quantification requires an excellent experiments selection that allows to define a complete evaluation matrix, and the comparison of the simulations results with the experiments measured data, as well as in the relative to the scaling of these phenomena. To simulate these experiments it was necessary to modify the original code, because it was not able to reproduce, in a qualitative way, the expected phenomenology. It can be concluded that there is a good agreement between the TRAC-PF1/NEM results and the experimental data. Once average error ({epsilon}) and standard deviation ({sigma}) for those correlations under study are obtained, these factors could be used to correct in a conservative

  20. Investigation of the effects of soluble boron tracking on coupled CTF / NEM, LWR simulations

    SciTech Connect (OSTI)

    Biery, M.; Avramova, M.; Ivanov, K.

    2013-07-01

    The primary objective of this study is to evaluate the effects of introducing a boron tracking capability to the COBRA-TF / NEM code coupling. The Pennsylvania State University (PSU) versions of COBRA-TF - CTF, and Nodal Expansion Method (NEM) codes are utilized. Previous implementations of the CTF / NEM coupled code had no capability to model soluble boron feedback effects due to boron transport. This study builds upon the validation and qualification efforts of the boron tracking model implementation in CTF by modeling the boron feedback calculated by the CTF boron tracking model in NEM. The core model chosen for this study is the Purdue MOX/UO{sub 2} core model used in the 2007 OECD/NRC code benchmark study. Following the implementation of an explicit online coupling scheme and accompanying k-search routine, the newly coupled CTF / NEM code version with boron tracking is compared to prior results of the non-boron tracking CTF / NEM code version at steady-state hot full power and hot zero power conditions. It was found that the boron tracking model exhibited little influence on the hot zero power result as expected due to a smaller heat flux, which does not significantly change the moderator density and boron concentration as the moderator travels up the axial core length. Meanwhile the boron tracking model had a much greater impact on the hot full power results, predicting the critical inlet boron concentration to be 9.9 ppm below the non-boron tracking result due to greater and more rapid changes in boron concentration corresponding to the reduction in moderator density from being more rapidly heated. (authors)

  1. MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hershey, David M.; Ren, Xuefeng; Melnyk, Ryan A.; Browne, Patrick J.; Ozyamak, Ertan; Jones, Stephanie R.; Chang, Michelle C. Y.; Hurley, James H.; Komeili, Arash

    2016-03-16

    Many living organisms transform inorganic atoms into highly ordered crystalline materials. An elegant example of such biomineralization processes is the production of nano-scale magnetic crystals in magnetotactic bacteria. Previous studies have implicated the involvement of two putative serine proteases, MamE and MamO, during the early stages of magnetite formation in Magnetospirillum magneticum AMB-1. Here, using genetic analysis and X-ray crystallography, we show that MamO has a degenerate active site, rendering it incapable of protease activity. Instead, MamO promotes magnetosome formation through two genetically distinct, noncatalytic activities: activation of MamE-dependent proteolysis of biomineralization factors and direct binding to transition metal ions.more » By solving the structure of the protease domain bound to a metal ion, we identify a surface-exposed di-histidine motif in MamO that contributes to metal binding and show that it is required to initiate biomineralization in vivo. Finally, we find that pseudoproteases are widespread in magnetotactic bacteria and that they have evolved independently in three separate taxa. In conclusion, our results highlight the versatility of protein scaffolds in accommodating new biochemical activities and provide unprecedented insight into the earliest stages of biomineralization.« less

  2. Appendix E: Other NEMS-MP results for the base case and scenarios.

    SciTech Connect (OSTI)

    Plotkin, S. E.; Singh, M. K.; Energy Systems

    2009-12-03

    The NEMS-MP model generates numerous results for each run of a scenario. (This model is the integrated National Energy Modeling System [NEMS] version used for the Multi-Path Transportation Futures Study [MP].) This appendix examines additional findings beyond the primary results reported in the Multi-Path Transportation Futures Study: Vehicle Characterization and Scenario Analyses (Reference 1). These additional results are provided in order to help further illuminate some of the primary results. Specifically discussed in this appendix are: (1) Energy use results for light vehicles (LVs), including details about the underlying total vehicle miles traveled (VMT), the average vehicle fuel economy, and the volumes of the different fuels used; (2) Resource fuels and their use in the production of ethanol, hydrogen (H{sub 2}), and electricity; (3) Ethanol use in the scenarios (i.e., the ethanol consumption in E85 vs. other blends, the percent of travel by flex fuel vehicles on E85, etc.); (4) Relative availability of E85 and H2 stations; (5) Fuel prices; (6) Vehicle prices; and (7) Consumer savings. These results are discussed as follows: (1) The three scenarios (Mixed, (P)HEV & Ethanol, and H2 Success) when assuming vehicle prices developed through literature review; (2) The three scenarios with vehicle prices that incorporate the achievement of the U.S. Department of Energy (DOE) program vehicle cost goals; (3) The three scenarios with 'literature review' vehicle prices, plus vehicle subsidies; and (4) The three scenarios with 'program goals' vehicle prices, plus vehicle subsidies. The four versions or cases of each scenario are referred to as: Literature Review No Subsidies, Program Goals No Subsidies, Literature Review with Subsidies, and Program Goals with Subsidies. Two additional points must be made here. First, none of the results presented for LVs in this section include Class 2B trucks. Results for this class are included occasionally in Reference 1. They

  3. A sensitivity analysis of the treatment of wind energy in the AEO99 version of NEMS

    SciTech Connect (OSTI)

    Osborn, Julie G; Wood, Frances; Richey, Cooper; Sanders, Sandy; Short, Walter; Koomey, Jonathan

    2001-01-01

    Each year, the U.S. Department of Energy's Energy Information Administration (EIA) publishes a forecast of the domestic energy economy in the Annual Energy Outlook (AEO). During the forecast period of the AEO (currently through 2020), renewable energy technologies have typically not achieved significant growth. The contribution of renewable technologies as electric generators becomes more important, however, in scenarios analyzing greenhouse gas emissions reductions or significant technological advancements. We examined the economic assumptions about wind power used for producing forecasts with the National Energy Modeling System (NEMS) to determine their influence on the projected capacity expansion of this technology. This analysis should help illustrate to policymakers what types of issues may affect wind development, and improve the general understanding of the NEMS model itself. Figure 1 illustrates the model structure and factors relevant to wind deployment. We found that NEMS uses various cost multipliers and constraints to represent potential physical and economic limitations to growth in wind capacity, such as resource depletion, costs associated with rapid manufacturing expansion, and grid stability with high levels of capacity from intermittent resources. The model's flexibility allows the user to make alternative assumptions about the magnitude of these factors. While these assumptions have little effect on the Reference Case forecast for the 1999 edition of the AEO, they can make a dramatic difference when wind is more attractive, such as under a carbon permit trading system. With $100/ton carbon permits, the wind capacity projection for 2020 ranges from 15 GW in the unaltered model (AEO99 Reference Case) to 168 GW in the extreme case when all the multipliers and constraints examined in this study are removed. Furthermore, if modifications are made to the model allowing inter-regional transmission of electricity, wind capacity is forecast to reach 214

  4. External Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    External Links External Links This page contains links to web sites and pages having to do with the Federal Energy Technology Network, Department of Energy, and Energy related ...

  5. Science and technology of piezoelectric/diamond heterostructures for monolithically integrated high performance MEMS/NEMS/CMOS devices.

    SciTech Connect (OSTI)

    Auciello, O.; Sumant, A. V.; Hiller, J.; Kabius, B.; Ma, Z.; Srinivasan, S.

    2008-12-01

    This paper describes the fundamental and applied science performed to integrate piezoelectric PbZr{sub x}Ti{sub 1-x}O{sub 3} and AlN films with a novel mechanically robust ultrananocrystalline diamond layer to enable a new generation of low voltage/high-performance piezoactuated hybrid piezoelectric/diamond MEMS/NEMS devices.

  6. A 2D/1D coupling neutron transport method based on the matrix MOC and NEM methods

    SciTech Connect (OSTI)

    Zhang, H.; Zheng, Y.; Wu, H.; Cao, L.

    2013-07-01

    A new 2D/1D coupling method based on the matrix MOC method (MMOC) and nodal expansion method (NEM) is proposed for solving the three-dimensional heterogeneous neutron transport problem. The MMOC method, used for radial two-dimensional calculation, constructs a response matrix between source and flux with only one sweep and then solves the linear system by using the restarted GMRES algorithm instead of the traditional trajectory sweeping process during within-group iteration for angular flux update. Long characteristics are generated by using the customization of commercial software AutoCAD. A one-dimensional diffusion calculation is carried out in the axial direction by employing the NEM method. The 2D and ID solutions are coupled through the transverse leakage items. The 3D CMFD method is used to ensure the global neutron balance and adjust the different convergence properties of the radial and axial solvers. A computational code is developed based on these theories. Two benchmarks are calculated to verify the coupling method and the code. It is observed that the corresponding numerical results agree well with references, which indicates that the new method is capable of solving the 3D heterogeneous neutron transport problem directly. (authors)

  7. Links - SRSCRO

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    links Links Surplus Equipment Bolin Marketing Group | www.bmgsurplus.com Counties of the SRSCRO Region Aiken County | www.aikencounty.net Allendale County | www.allendalecounty.com Barnwell County | www.barnwellcounty.sc.gov Columbia County | www.columbiacountyga.gov Richmond County | www.augustaga.gov Chambers of Commerce Aiken SC | www.aikenchamber.net Augusta, GA | www.augustagausa.com Barnwell, SC | www.barnwellcountychamber.org Columbia County, GA | www.columbiacountychamber.com North

  8. MIDC: Links

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    Links Other Data Collection Activities Baseline Surface Radiation Network (BSRN) Clear Sky Forcast for NREL/SRRL (or other locations) Colorado Dept. of Public Health & Environment: Air Quality Index (AQI) Reporting System Colorado State University: USDA UV-B Monitoring and Research Program European Skynet Radiometers network (ESR) Jefferson County, Colorado: Jeffco Weather Station NOAA: Climate Monitoring & Diagnostics Laboratory (CMDL) NREL OTF: Reference Meteorological and Irradiance

  9. Large-area low-temperature ultrananocrystaline diamond (UNCD) films and integration with CMOS devices for monolithically integrated diamond MEMD/NEMS-CMOS systems.

    SciTech Connect (OSTI)

    Sumant, A.V.; Auciello, O.; Yuan, H.-C; Ma, Z.; Carpick, R. W.; Mancini, D. C.; Univ. of Wisconsin; Univ. of Pennsylvania

    2009-05-01

    Because of exceptional mechanical, chemical, and tribological properties, diamond has a great potential to be used as a material for the development of high-performance MEMS and NEMS such as resonators and switches compatible with harsh environments, which involve mechanical motion and intermittent contact. Integration of such MEMS/NEMS devices with complementary metal oxide semiconductor (CMOS) microelectronics will provide a unique platform for CMOS-driven commercial MEMS/NEMS. The main hurdle to achieve diamond-CMOS integration is the relatively high substrate temperatures (600-800 C) required for depositing conventional diamond thin films, which are well above the CMOS operating thermal budget (400 C). Additionally, a materials integration strategy has to be developed to enable diamond-CMOS integration. Ultrananocrystalline diamond (UNCD), a novel material developed in thin film form at Argonne, is currently the only microwave plasma chemical vapor deposition (MPCVD) grown diamond film that can be grown at 400 C, and still retain exceptional mechanical, chemical, and tribological properties comparable to that of single crystal diamond. We have developed a process based on MPCVD to synthesize UNCD films on up to 200 mm in diameter CMOS wafers, which will open new avenues for the fabrication of monolithically integrated CMOS-driven MEMS/NEMS based on UNCD. UNCD films were grown successfully on individual Si-based CMOS chips and on 200 mm CMOS wafers at 400 C in a MPCVD system, using Ar-rich/CH4 gas mixture. The CMOS devices on the wafers were characterized before and after UNCD deposition. All devices were performing to specifications with very small degradation after UNCD deposition and processing. A threshold voltage degradation in the range of 0.08-0.44V and transconductance degradation in the range of 1.5-9% were observed.

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  4. NEMS Modeling of Coal Plants

    U.S. Energy Information Administration (EIA) Indexed Site

    Liquid Fuels Market Module Model inputs for coal plants 3 * Existing coal plants - plant specific ... FF - Cost to convert to natural gas-fired steam plant - Cost to implement heat ...

  5. MAJOR CONFORMED CONTRACTS LINKS Site/Project Contract Link Idaho

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    MAJOR CONFORMED CONTRACTS LINKS SiteProject Contract Link Idaho Idaho Cleanup Project http:www.id.doe.govdoeidICPContractICPContract.htm Advance Mixed Waste Treatment http:...

  6. Balanced link for dry coal extrusion pumps

    DOE Patents [OSTI]

    Bebejian, Maral

    2013-10-22

    A link which defines a link body that includes a multiple of link plates integral with a link body, the link body disposed at least partially forward of a forward edge of the multiple of link plates.

  7. Nuclear Data Links

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    Links to Other Useful Sites Online Journals Institutions and Programs Related to Nuclear Physics U.S. Nuclear Data Program: All evaluated nuclear data supported by the U.S. Department of Energy. National Nuclear Data Center: Brookhaven National Laboratory; Evaluated Nuclear Structure Data Files (ENSDF), Nuclear Science References (NSR) and other databases. Isotopes Project: (E.O.L. Berkeley National Laboratory) Table of Isotopes, Isotope Explorer, XUNDL, Nuclear Data Dissemination Homepage, and

  8. Page 11, Links

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    11 of 11 Previous Page Links Information for Employees & In-Processing DOE Order 3792.3 - Drug-Free Federal Workplace Testing http://www.archives.gov/federal-register/codification/executive-order/12564.html Flexible Spending Accounts (FSA) https://www.fsafeds.com/fsafeds/index.asp Pay & Pay Scales http://www.opm.gov/a-z-index/ Benefits Facts on Leave Programs http://www.opm.gov/policy-data-oversight/pay-leave/leave-administration/ Health Benefits

  9. CAMD Nanofabrication Links

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    Research :: Publications :: Infrastructure :: Links :: Nanofabrication Facility in News Nano 50TM Awards: The Nano 50TM Awards, presented by Nanotech Briefs magazine, recognize the top 50 technologies, products and innovators that have significantly impacted, or are expected to impact, the state of the art in nanotechnology. "The winners of the Nano 50 awards are the best of the best - the innovative people and technologies that will continue to move nanotechnology to key mainstream

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    Links UW Madison Madison Symmetric Torus Links MST HomeGraduate Student InformationLinksTourControl and Auxiliary SystemsPhysics TopicsDeviceResearch MissionMST People mst logo CPLA Home Directory Publications Links Internal University of Wisconsin Physics Department Research funding includes support from: Department of Energy National Science Foundation Other Reversed Field Pinch Experiments around the world: RFX-mod in Padua, Italy Extrap-T2R in Stockhom, Sweden RELAX at Kyoto Institute of

  15. Beryllium Related Links - Hanford Site

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    Related Links About Us Hanford Cultural Resources Beryllium Program Beryllium Program Points of Contact Beryllium Facilities & Areas Beryllium Program Information Hanford CBDPP Committee Beryllium FAQs Beryllium Related Links Hanford Beryllium Awareness Group (BAG) Program Performance Assessments Beryllium Program Feedback Beryllium Health Advocates Primary Contractors/Employers Medical Testing and Surveillance Facilities General Resources Beryllium Related Links Email Email Page | Print

  16. Multilevel DC link inverter

    DOE Patents [OSTI]

    Su, Gui-Jia

    2003-06-10

    A multilevel DC link inverter and method for improving torque response and current regulation in permanent magnet motors and switched reluctance motors having a low inductance includes a plurality of voltage controlled cells connected in series for applying a resulting dc voltage comprised of one or more incremental dc voltages. The cells are provided with switches for increasing the resulting applied dc voltage as speed and back EMF increase, while limiting the voltage that is applied to the commutation switches to perform PWM or dc voltage stepping functions, so as to limit current ripple in the stator windings below an acceptable level, typically 5%. Several embodiments are disclosed including inverters using IGBT's, inverters using thyristors. All of the inverters are operable in both motoring and regenerating modes.

  17. Protective link for superconducting coil

    DOE Patents [OSTI]

    Umans, Stephen D.

    2009-12-08

    A superconducting coil system includes a superconducting coil and a protective link of superconducting material coupled to the superconducting coil. A rotating machine includes first and second coils and a protective link of superconducting material. The second coil is operable to rotate with respect to the first coil. One of the first and second coils is a superconducting coil. The protective link is coupled to the superconducting coil.

  18. Links | National Nuclear Security Administration

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    Links | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy...

  19. LTS Related Links - Hanford Site

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    Related Links About Us Hanford Cultural Resources LTS Home Page LTS Project Management LTS Transition and Timeline LTS Execution LTS Background LTS Information Management LTS Fact Sheets / Briefings LTS In The News LTS Related Links LTS Contact Us LTS Related Links Email Email Page | Print Print Page | Text Increase Font Size Decrease Font Size Hanford Site Cleanup Completion Framework (DOE/RL 2009-10) (PDF) Hanford Long-Term Stewardship Program Plan (DOE/RL 2010-35) (PDF) DOE-EM LTS Site Legacy

  20. Multiple weak-link SQUID

    SciTech Connect (OSTI)

    Kroger, H.

    1980-09-23

    The disclosed SQUID (Superconducting quantum interference device) comprises two superposed superconductive layers with an insulating layer therebetween. A plurality of holes through the insulating layer filled with superconductive material form weak links between the superconductive layers. One or more control lines superposed with respect to the superconductive layers provide magnetic flux through the area between the weak links to control the zero voltage supercurrent flowing through the weak links from one of the superconductive layers to the other thereby providing the switching function for Josephson superconductive circuits.

  1. E-Link - User Account

    Office of Scientific and Technical Information (OSTI)

    Energy Link (E-LINK) Access Request FOR DOE MAJOR SITE/FACILITY MANAGEMENT CONTRACTOR AND DOE HEADQUARTERS AND FIELD OFFICE PERSONNEL ONLY (Financial Assistance Recipients/Non-Major Site/Facility Management Contractors, go to www.osti.gov/elink-2413/) Major Site/Facility Management Contractors and DOE Headquarters and Field personnel are required to obtain a user name and password to access E-Link submissions and related reports. The process to obtain a user name and password also requires the

  2. Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Related Links Related Links Private, public, and nonprofit organizations around the country offer a wide range of courses and other services to help you either improve your current skills or learn new ones. The sites featured here can help you find courses of specific interest as well as other information about training requirements for certain energy jobs. DOE Related Advanced Manufacturing Office: Training Find training sessions in your area and learn how to save energy in your manufacturing

  3. Alternative Fuels Data Center: Biodiesel Related Links

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Biodiesel Printable Version Share this resource Send a link to Alternative Fuels Data Center: Biodiesel Related Links to someone by E-mail Share Alternative Fuels Data Center: Biodiesel Related Links on Facebook Tweet about Alternative Fuels Data Center: Biodiesel Related Links on Twitter Bookmark Alternative Fuels Data Center: Biodiesel Related Links on Google Bookmark Alternative Fuels Data Center: Biodiesel Related Links on Delicious Rank Alternative Fuels Data Center: Biodiesel Related Links

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    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Ethanol Printable Version Share this resource Send a link to Alternative Fuels Data Center: Ethanol Related Links to someone by E-mail Share Alternative Fuels Data Center: Ethanol Related Links on Facebook Tweet about Alternative Fuels Data Center: Ethanol Related Links on Twitter Bookmark Alternative Fuels Data Center: Ethanol Related Links on Google Bookmark Alternative Fuels Data Center: Ethanol Related Links on Delicious Rank Alternative Fuels Data Center: Ethanol Related Links on Digg Find

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    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Hydrogen Printable Version Share this resource Send a link to Alternative Fuels Data Center: Hydrogen Related Links to someone by E-mail Share Alternative Fuels Data Center: Hydrogen Related Links on Facebook Tweet about Alternative Fuels Data Center: Hydrogen Related Links on Twitter Bookmark Alternative Fuels Data Center: Hydrogen Related Links on Google Bookmark Alternative Fuels Data Center: Hydrogen Related Links on Delicious Rank Alternative Fuels Data Center: Hydrogen Related Links on

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    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Propane Printable Version Share this resource Send a link to Alternative Fuels Data Center: Propane Related Links to someone by E-mail Share Alternative Fuels Data Center: Propane Related Links on Facebook Tweet about Alternative Fuels Data Center: Propane Related Links on Twitter Bookmark Alternative Fuels Data Center: Propane Related Links on Google Bookmark Alternative Fuels Data Center: Propane Related Links on Delicious Rank Alternative Fuels Data Center: Propane Related Links on Digg Find

  7. Alternative Fuels Data Center: Related Links

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Tools Printable Version Share this resource Send a link to Alternative Fuels Data Center: Related Links to someone by E-mail Share Alternative Fuels Data Center: Related Links on Facebook Tweet about Alternative Fuels Data Center: Related Links on Twitter Bookmark Alternative Fuels Data Center: Related Links on Google Bookmark Alternative Fuels Data Center: Related Links on Delicious Rank Alternative Fuels Data Center: Related Links on Digg Find More places to share Alternative Fuels Data

  8. Khovanov homology of graph-links

    SciTech Connect (OSTI)

    Nikonov, Igor M

    2012-08-31

    Graph-links arise as the intersection graphs of turning chord diagrams of links. Speaking informally, graph-links provide a combinatorial description of links up to mutations. Many link invariants can be reformulated in the language of graph-links. Khovanov homology, a well-known and useful knot invariant, is defined for graph-links in this paper (in the case of the ground field of characteristic two). Bibliography: 14 titles.

  9. Links

    Broader source: Energy.gov [DOE]

    More Legal Research ResourcesEnergy Law NetLegal Citation Style GuideNuclear Regulatory LegislationOpen CRSPublic Library of LawTreatiesU.S. Code Classification TablesU.S. Congressional Documents...

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  11. ElectraLink | Open Energy Information

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  13. Help:Linked images | Open Energy Information

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    Linked images Redirect page Jump to: navigation, search REDIRECT Manual:Linked images Retrieved from "http:en.openei.orgwindex.php?titleHelp:Linkedimages&oldid58478" ...

  14. BizLink Technology | Open Energy Information

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    BizLink Technology Jump to: navigation, search Name: BizLink Technology Place: Fremont, California Zip: 94538 Sector: Solar Product: California-based manufacturer of solar modules,...

  15. Voluntary Protection Program - Related Links | Department of...

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    - Related Links Voluntary Protection Program - Related Links VPPPA - The Voluntary Protection Programs Participants' Association, a non- profit organization is leading the way in ...

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    FAQ Useful Links Useful Links Detailed campus map with CEFRC summer school buildings highlighted (NEW) Schedule of Events (NEW) Campus Map with CEFRC-specific buildings...

  17. AlumniLink: January 2015

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    Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit IN THIS ISSUE New Science 100 supercomputers later Explosives performance key to stockpile stewardship Software speeds detection of diseases and cancer-treatment targets Alumni spotlight Ni Ni: University of California - Los Angeles Francesco Grilli: Karlsruhe Institute of Technology Funding opportunities Potential partnerships and funding from a variety of sources

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    Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit IN THIS ISSUE New Science Project ATHENA creates surrogate human organ systems Uncovering the mysteries of cosmic explosions Portable MRI could aid wounded soldiers and children in the Third World Where former employees are now Alumni: Zoltán Toroczkai, University of Notre Dame Alumni: Sarah Nurre, University of Arkansas Funding opportunities Potential partnerships

  19. AlumniLink: June 2014

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    Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit IN THIS ISSUE New science Neutrons provide new insights into human cell behavior Physics and biology intersect in breakthroughs Metallic glass could make your next cell phone harder to break Lab researcher works to rearrange the atoms in metals Alumni spotlight Shadi Dayeh: UCSD Former postdoc now an Associate Professor with the Jacobs School of Engineering at the UC

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    Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit IN THIS ISSUE New Science One in five online scholarly articles affected by 'reference rot' Scientists call for antibody 'bar code' system to follow Human Genome Project Los Alamos develops new technique for growing high-efficiency perovskite solar cells Alumni spotlight Mark Jankowski: Minnesota Pollution Control Agency Madalina Furis: University of Vermont Funding

  1. AlumniLink: May 2015

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    Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit IN THIS ISSUE New Science Using magnetic fields to understand high-temperature superconductivity Los Alamos creates bioinformatics tool for metagenome analysis Multi-institutional project to study climate change's effect on tropical forests Where former employees are now Alumni: Claire White, Princeton University Alumni: Chih-Chun Chien, University of California Merced

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    Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit IN THIS ISSUE New Science Climate, Earth system project draws on science powerhouses Three climate change drivers and corresponding questions for project's initial phase Collaboration drives achievement in protein structure research By tracking down how bacterial defense systems work, the scientists can potentially fight infectious diseases and genetic disorders Secure

  3. AlumniLink: September 2014

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    Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit IN THIS ISSUE New science Probing Fukushima with cosmic rays should speed cleanup Could reduce the time required for clean up Scientists uncover combustion mechanism to better predict warming by wildfires Scientists have uncovered key attributes of so-called "brown carbon" from wildfires High-performance computer system installed at Los Alamos National

  4. AlumniLink: September 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit IN THIS ISSUE New science and news Young, Jupiter-like planet discovered Four Los Alamos projects selected as R&D 100 Award finalists Seven federally protected Mexican spotted owl chicks hatch on Lab property Where former employees are now Alumni: Duane Hatch, Belmont University Alumni: Alexia Schulz, MIT Lincoln Laboratory Funding opportunities Potential

  5. Join our highlighted LinkedIn discussion

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    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion What experiences have alumni had in software releases and deployments at different institutions? March 1, 2015 Robert Jilek Robert Jilek Contact Linda Anderman Email alumni LinkedIn Join us for a variety of discussions on the Lab's LinkedIn Alumni page What experiences have alumni had in

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    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion Congratulations to LANL's Claudia Mora for being selected president elect of the Geological Society of America! July 1, 2015 Claudia Mora Claudia Mora Contact Linda Anderman Email alumni LinkedIn Join us for a variety of discussions on the Lab's LinkedIn Alumni page Congratulations to

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    Office of Scientific and Technical Information (OSTI)

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  9. Liquid Fuels Market Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Defines the objectives of the Liquid Fuels Market Model (LFMM), describes its basic approach, and provides detail on how it works. This report is intended as a reference document for model analysts, users, and the public.

  10. Energy Information Administration NEMS Macroeconomic Activity...

    Gasoline and Diesel Fuel Update (EIA)

    of employment by industry is industrial output. Both current and lagged output values enter in the employment specification, reflecting the tendency of firms to hire employees in...

  11. Microsoft Word - MAM2006_013106.doc

    Gasoline and Diesel Fuel Update (EIA)

    of employment by industry is industry output. Both current and lagged output values enter in the employment specification, reflecting the tendency for hiring to lag output...

  12. linked open data | OpenEI Community

    Open Energy Info (EERE)

    linked open data Home Jweers's picture Submitted by Jweers(88) Contributor 10 October, 2012 - 08:20 LOD Workshop Invitation Event linked open data LOD Open Data workshop Update the...

  13. Link Force Holdings Ltd | Open Energy Information

    Open Energy Info (EERE)

    search Name: Link Force Holdings Ltd Place: China Product: China-based energy saving LED street light maker. References: Link Force Holdings Ltd1 This article is a stub. You...

  14. Tunable Thermal Link - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tunable Thermal Link Lawrence Berkeley National Laboratory Contact LBL About This Technology Technology Marketing SummaryThermal links are incorporated into everything from frying pans to internal combustion engine spark plugs and heat sinks on integrated circuit boards. Typically, the link's thermal resistance is fixed and cannot be tuned after manufacture. While the ability to tune electrical resistors is widespread, virtually no tunable thermal resistance link exists, which has held back the

  15. Track with overlapping links for dry coal extrusion pumps

    DOE Patents [OSTI]

    Saunders, Timothy; Brady, John D

    2014-01-21

    A chain for a particulate material extrusion pump includes a plurality of links, each of the plurality of links having a link body and a link ledge, wherein each link ledge of the plurality of links at least partially overlaps the link body of an adjacent one of the plurality of links.

  16. E-print Network Website Policies and Important Links -- Energy...

    Office of Scientific and Technical Information (OSTI)

    Website Policies Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  17. 2015 Aser links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Aser links 2015 Aser links Annual Site Environmental Reports (ASER); Sites; contacts; email 2015 ASER links (94.62 KB) More Documents & Publications DOE Annual Site Environmental Reports (ASER) 2010 Annual Site Environmental Report (ASER) Supplement 2011 Annual Site Environmental Report (ASER) Supplement

  18. Join our highlighted LinkedIn discussion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion Do you use social media when at conferences? November 1, 2014 Robert Jilek Robert Jilek Contact Linda Anderman Email alumni LinkedIn Join us for a variety of discussions on the Lab's LinkedIn Alumni page Do you use social media when at conferences? We are fascinated by this question and

  19. Join our highlighted LinkedIn discussion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion Top science stories of 2014 from Los Alamos National Lab January 1, 2015 Robert Jilek Robert Jilek Contact Linda Anderman Email alumni LinkedIn Join us for a variety of discussions on the Lab's LinkedIn Alumni page Top science stories of 2014 from Los Alamos National Lab What was your

  20. Adjustable link for kinematic mounting systems

    DOE Patents [OSTI]

    Hale, L.C.

    1997-07-01

    An adjustable link for kinematic mounting systems is disclosed. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two. 3 figs.

  1. Adjustable link for kinematic mounting systems

    DOE Patents [OSTI]

    Hale, Layton C.

    1997-01-01

    An adjustable link for kinematic mounting systems. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two.

  2. DOE - NNSA/NFO -- FRMAC Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Home > National Security > Homeland Security > FRMAC > Links NNSA/NFO Language Options U.S. DOE/NNSA - Nevada Field Office FRMAC Links Instructions: Click the -/+ next to the Category name to collapse or expand the listings collapse Category: Assets Atmospheric Release Advisory Capability Radiological Emergency Assistance Center/Training Site (REAC/TS) collapse Category: Federal Agency Links Emergency Operations Training Academy Environmental Protection Agency (EPA) Federal

  3. Fuel Cells Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fuel Cells » Fuel Cells Related Links Fuel Cells Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded fuel cell activities, research plans and roadmaps, partnerships, and additional related links. DOE-Funded Fuel Cell Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters and presentations from the

  4. Hydrogen Delivery Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery » Hydrogen Delivery Related Links Hydrogen Delivery Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded hydrogen delivery activities, research plans and roadmaps, models and tools, and additional related links. DOE-Funded Hydrogen Delivery Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters

  5. Hydrogen Production Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Production Related Links Hydrogen Production Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded hydrogen production activities, research plans and roadmaps, models and tools, and additional related links. DOE-Funded Hydrogen Production Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters and

  6. Hydrogen Storage Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Related Links Hydrogen Storage Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded hydrogen storage activities, research plans and roadmaps, models and tools, and additional related links. DOE-Funded Hydrogen Storage Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters and presentations from the latest

  7. Join our highlighted LinkedIn discussion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion Descartes Labs is using deep learning technology developed at LANL to help us better understand our world May 1, 2015 The site offers a variety of Los Alamos-developed biosurveillance tools that can be used for decision support in disease surveillance. The site offers a variety of Los

  8. Related Links | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Association for Computing Machinery External link Computing Research Association External link International Exascale Software Project External link Last modified: 352016 7:59:23

  9. OSTIblog Articles in the reference linking Topic | OSTI, US Dept...

    Office of Scientific and Technical Information (OSTI)

    reference linking Topic OSTI and Reference Linking by Daphne Evans 13 May, 2008 in Technology OSTI actively supports the practice of Reference Linking. Also referred to as citation ...

  10. Linked Energy Data | OpenEI

    Open Energy Info (EERE)

    traditional web provides interlinked documents that are designed for humans to read, the web of Linked Data provides interlinked data that is designed to be processed by software...

  11. WaikatoLink Limited | Open Energy Information

    Open Energy Info (EERE)

    Limited Jump to: navigation, search Name: WaikatoLink Limited Place: New Zealand Sector: Services Product: General Financial & Legal Services ( Individual Angel network )...

  12. Property:Incentive/Auth7Link | Open Energy Information

    Open Energy Info (EERE)

    Auth7Link Jump to: navigation, search Property Name IncentiveAuth7Link Property Type URL Description Url link to authority. Pages using the property "IncentiveAuth7Link" Showing...

  13. Property:Incentive/Auth9Link | Open Energy Information

    Open Energy Info (EERE)

    Auth9Link Jump to: navigation, search Property Name IncentiveAuth9Link Property Type URL Description Url link to authority. Pages using the property "IncentiveAuth9Link" Showing...

  14. Property:Incentive/Auth11Link | Open Energy Information

    Open Energy Info (EERE)

    1Link Jump to: navigation, search Property Name IncentiveAuth11Link Property Type URL Description Url link to authority Pages using the property "IncentiveAuth11Link" Showing 20...

  15. Jonathan Link, Columbia NuCosmo '02

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7-19, 2002 Jonathan Link, Columbia NuCosmo '02 Jonathan Link Columbia University Workshop on Neutrino News from the Lab and the Cosmos October 17-19, 2002 October 17-19, 2002 Jonathan Link, Columbia NuCosmo '02 Outline 1. The LSND Experiment a. The experimental setup b. Results c. Ramifications 2. MiniBooNE a. The BooNE Collaboration b. The beam line and expected neutrino flux c. The MiniBooNE detector d. Expected backgrounds and systematics e. First neutrino events, and cosmic rays f.

  16. Jonathan Link, Columbia KEK Topical Conference

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    -22, 2001 Jonathan Link, Columbia KEK Topical Conference Short Baseline Neutrino Oscillations and MiniBooNE Jonathan Link Columbia University The 5 th KEK Topical Conference - Frontiers in Flavor Physics November 20-22, 2001 November 20-22, 2001 Jonathan Link, Columbia KEK Topical Conference Outline 1. Background on Short Baseline Neutrino Oscillations * A little neutrino physics * The LSND oscillation result 2. About MiniBooNE 3. Status of MiniBooNE. Some of you may have noticed that I'll be

  17. EEO Links | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Links DOE Office of Civil Rights Department Of Justice Civil Rights Division Department of Veterans Affairs Equal Employment Opportunity Commission Office of Personnel Management U.S. Merit Systems Protection Board U.S. Office of Special Counsel

  18. OpenEI Community - linked open data

    Open Energy Info (EERE)

    linked-open-data-workshop-washington-dc

  19. Highly cross-linked nanoporous polymers

    DOE Patents [OSTI]

    Steckle, Jr., Warren P.; Apen, Paul G.; Mitchell, Michael A.

    1998-01-01

    Condensation polymerization followed by a supercritical extraction step can be used to obtain highly cross-linked nanoporous polymers with high surface area, controlled pore sizes and rigid structural integrity. The invention polymers are useful for applications requiring separation membranes.

  20. Highly cross-linked nanoporous polymers

    DOE Patents [OSTI]

    Steckle, Jr., Warren P.; Apen, Paul G.; Mitchell, Michael A.

    1997-01-01

    Condensation polymerization followed by a supercritical extraction step can be used to obtain highly cross-linked nanoporous polymers with high surface area, controlled pore sizes and rigid structural integrity. The invention polymers are useful for applications requiring separation membranes.

  1. Related Links | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Related Links NNSA and Other Related Links DOE/NNSA Phonebook Freedom of Information Act Department of Energy DOE Directives DOE Jobs Online Defense Nuclear Facilities Safety Board DOE Pulse Publication DOE Office of Health, Safety and Security USA.Gov Los Alamos County Los Alamos National Laboratory LANL Phonebook National Nuclear Security Administration NNSA Service Center - Albuquerque NNSA Nevada Field Office New Mexico Environmental Department - LANL Sandia National Laboratories Waste

  2. Environmental Justice Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Links Environmental Justice Links Public Information Center DOE Library U.S. Department of Health and Human Services (HHS), National Health Information Center U.S. Department of Health and Human Services (HHS), Office of Minority Health Resource Center U.S. Department of Housing and Urban Development Online Library U.S. Department of Interior Library U.S. Department of Labor Library U.S. Department of Transportation (DOT) Library U.S. Environmental Protection Agency Library Services for the

  3. Guiding Documents and Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Guiding Documents and Links Guiding Documents and Links Federal Executive Order 13653, Preparing the United States for the Impacts of Climate Change Executive Order 13693, Planning for Federal Sustainability in the Next Decade DOE DOE Orders DOE Order 430.1B - Real Property and Asset Management DOE Order 436.1 - Departmental Sustainability DOE Policy 450.4A - Integrated Safety Management Policy 2014 DOE Strategic Sustainability Performance Plan LM Documents EMS Description LM Environmental

  4. Thermochemical Conversion Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Conversion » Thermochemical Conversion Related Links Thermochemical Conversion Related Links Further reading about current Bioenergy Technologies Office R&D in the Thermochemical Platform can be found in this website's Information Resources section. Some key publications are: Biomass Conversion: From Feedstocks to Final Products (July 2016) Thermochemical Conversion 2009 Peer Review Design Case Summary: Production of Gasoline and Diesel from Biomass via Fast Pyrolysis, Hydrotreating, and

  5. Feedstock Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Research & Development » Feedstocks » Feedstock Related Links Feedstock Related Links There are a variety of other resources available for information on biomass feedstocks. We have organized some of those resources into the following categories: Other DOE Offices and Federal Agencies Department of Energy (DOE) Office of Science Biological and Environmental Research (BER) Biofuels Mission Focus DOE Office of Science BER Bioenergy Research Centers U.S. Department of Agriculture (USDA) 2007

  6. Links for Scientists and Researchers | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Links for Scientists and Researchers Below you will find links commonly used by scientists, users and others who conduct research at Jefferson Lab. Experimental Areas Hall A Hall B Hall C Hall D Other Work Areas Physics Division Work Planning Requirements Physics Division Work Governance Area Access for Students Training requirements for experimental areas Nuclear Physics Program Physics Home Page Experiment Schedule Three-Year Accelerator Schedule Program Advisory Committee (PAC) Experiment

  7. Archived Links: International EERE | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Archived Links: International EERE Archived Links: International EERE Below you may view and download the archived Success Stories / Fact Sheets from International EERE: Accelerating the Clean Energy Transition in South Africa (May 28, 2015) Fact Sheet: Accelerating the Deployment of Energy Efficiency & Renewable Energy in South Africa (May 27, 2015) Sustainable Energy for Remote Indonesian Grids Explores Opportunities in Stakeholder Workshop (October 15, 2014) Mapping Opportunities for U.S.

  8. Emerging semantics to link phenotype and environment

    SciTech Connect (OSTI)

    Thessen, Anne E.; Bunker, Daniel E.; Buttigieg, Pier Luigi; Cooper, Laurel D.; Dahdul, Wasila M.; Domisch, Sami; Franz, Nico M.; Jaiswal, Pankaj; Lawrence-Dill, Carolyn J.; Midford, Peter E.; Mungall, Christopher J.; Ramirez, Martin J.; Specht, Chelsea D.; Vogt, Lars; Vos, Rutger Aldo; Walls, Ramona L.; White, Jeffrey W.; Zhang, Guanyang; Deans, Andrew R.; Huala, Eva; Lewis, Suzanna E.; Mabee, Paula M.

    2015-12-14

    Understanding the interplay between environmental conditions and phenotypes is a fundamental goal of biology. Unfortunately, data that include observations on phenotype and environment are highly heterogeneous and thus difficult to find and integrate. One approach that is likely to improve the status quo involves the use of ontologies to standardize and link data about phenotypes and environments. Specifying and linking data through ontologies will allow researchers to increase the scope and flexibility of large-scale analyses aided by modern computing methods. Investments in this area would advance diverse fields such as ecology, phylogenetics, and conservation biology. While several biological ontologies are well-developed, using them to link phenotypes and environments is rare because of gaps in ontological coverage and limits to interoperability among ontologies and disciplines. Lastly, in this manuscript, we present (1) use cases from diverse disciplines to illustrate questions that could be answered more efficiently using a robust linkage between phenotypes and environments, (2) two proof-of-concept analyses that show the value of linking phenotypes to environments in fishes and amphibians, and (3) two proposed example data models for linking phenotypes and environments using the extensible observation ontology (OBOE) and the Biological Collections Ontology (BCO); these provide a starting point for the development of a data model linking phenotypes and environments.

  9. Emerging semantics to link phenotype and environment

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Thessen, Anne E.; Bunker, Daniel E.; Buttigieg, Pier Luigi; Cooper, Laurel D.; Dahdul, Wasila M.; Domisch, Sami; Franz, Nico M.; Jaiswal, Pankaj; Lawrence-Dill, Carolyn J.; Midford, Peter E.; et al

    2015-12-14

    Understanding the interplay between environmental conditions and phenotypes is a fundamental goal of biology. Unfortunately, data that include observations on phenotype and environment are highly heterogeneous and thus difficult to find and integrate. One approach that is likely to improve the status quo involves the use of ontologies to standardize and link data about phenotypes and environments. Specifying and linking data through ontologies will allow researchers to increase the scope and flexibility of large-scale analyses aided by modern computing methods. Investments in this area would advance diverse fields such as ecology, phylogenetics, and conservation biology. While several biological ontologies aremore » well-developed, using them to link phenotypes and environments is rare because of gaps in ontological coverage and limits to interoperability among ontologies and disciplines. Lastly, in this manuscript, we present (1) use cases from diverse disciplines to illustrate questions that could be answered more efficiently using a robust linkage between phenotypes and environments, (2) two proof-of-concept analyses that show the value of linking phenotypes to environments in fishes and amphibians, and (3) two proposed example data models for linking phenotypes and environments using the extensible observation ontology (OBOE) and the Biological Collections Ontology (BCO); these provide a starting point for the development of a data model linking phenotypes and environments.« less

  10. Links - Plasma Couette Experiment - Cary Forest Group - UW Plasma Physics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Links UW Madison Plasma Couette Experiment Links PCX HomeResearch MissionPhysics TopicsDeviceDiagnosticsContacts LinksPCX People CPLA Home Directory Publications Links University of Wisconsin Physics Department Department of Energy National Science Foundation No links yet

  11. Hawaii Noise Forms and Links Webpage | Open Energy Information

    Open Energy Info (EERE)

    and Links Webpage Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Hawaii Noise Forms and Links Webpage Abstract This webpage contains links to...

  12. Property:Incentive/Auth6Link | Open Energy Information

    Open Energy Info (EERE)

    Auth6Link Jump to: navigation, search Property Name IncentiveAuth6Link Property Type URL Pages using the property "IncentiveAuth6Link" Showing 25 pages using this property....

  13. OpenEI and Linked Open Data

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    OpenEI and Linked Open Data OpenEI: Open Energy Information + LOD: Linked Open Data Kate Young Jon Weers April 25, 2013 2 Open Energy Information http://en.openei.org * 1,239,000+ visitors from 200+ countries * Over 840 datasets * Creation of over 56,000 content pages * Upload of over 7,500 images and files * More than 620,000 contributor actions * Over 939,000 unique visitors * More than 5,000 registered users * Over 8,000 Twitter followers * More than 600 Facebook likes * Over 19 million RDF

  14. Alternative Fuels Data Center: Idle Reduction Related Links

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Conserve Fuel Printable Version Share this resource Send a link to Alternative Fuels Data Center: Idle Reduction Related Links to someone by E-mail Share Alternative Fuels Data Center: Idle Reduction Related Links on Facebook Tweet about Alternative Fuels Data Center: Idle Reduction Related Links on Twitter Bookmark Alternative Fuels Data Center: Idle Reduction Related Links on Google Bookmark Alternative Fuels Data Center: Idle Reduction Related Links on Delicious Rank Alternative Fuels Data

  15. Alternative Fuels Data Center: Natural Gas Related Links

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Natural Gas Printable Version Share this resource Send a link to Alternative Fuels Data Center: Natural Gas Related Links to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Related Links on Facebook Tweet about Alternative Fuels Data Center: Natural Gas Related Links on Twitter Bookmark Alternative Fuels Data Center: Natural Gas Related Links on Google Bookmark Alternative Fuels Data Center: Natural Gas Related Links on Delicious Rank Alternative Fuels Data Center: Natural Gas

  16. Links - Madison Dynamo Experiment - Cary Forest Group - UW Plasma Physics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Links UW Madison Madison Dynamo Experiment Links MDE HomeLinksNewsBackgroundPublicationsPresentationsContactsMDE People CPLA Home Directory Publications Links University of Wisconsin Physics Department Department of Energy National Science Foundation Local Links Plasma Physics in the UW Physics Department The Department of Physics University of Wisconsin - Madison Dynamo Links Riga Dynamo Experiment Karlsruhe Dynamo Experiment The Von-Karman Sodium Experiment Grenoble Geodynamo Experiment

  17. Linking Legacies: Connecting the Cold War Nuclear Weapons Production...

    Office of Environmental Management (EM)

    Linking Legacies: Connecting the Cold War Nuclear Weapons Production Processes to Their Environmental Consequences Linking Legacies: Connecting the Cold War Nuclear Weapons ...

  18. MicroLink Devices Inc | Open Energy Information

    Open Energy Info (EERE)

    search Name: MicroLink Devices, Inc. Place: Niles, Illinois Product: MicroLink Devices is a semiconductor manufacturer and system integrator that provides the latest...

  19. ECOWAS Clean Energy Gateway-Links | Open Energy Information

    Open Energy Info (EERE)

    ECOWAS Clean Energy Gateway-Links Jump to: navigation, search Economic Community of West African States (ECOWAS) Clean Energy Gateway Home | About | News | Links | Help | Countries...

  20. Draft New England Clean Power Link Project Environmental Impact...

    Broader source: Energy.gov (indexed) [DOE]

    December 2, 2014 VTNFDATAprojects57666.00 NE Clean Power LinkGISProjectNRMaps... December 2, 2014 VTNFDATAprojects57666.00 NE Clean Power LinkGISProjectNRMaps...

  1. Linking Advanced Visualization and MATLAB for the Analysis of...

    Office of Scientific and Technical Information (OSTI)

    Linking Advanced Visualization and MATLAB for the Analysis of 3D Gene Expression Data Citation Details In-Document Search Title: Linking Advanced Visualization and MATLAB for the ...

  2. High PID Resistant Cross-Linked Encapsulnt Based on Polyolefin...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PID Resistant Cross-Linked Encapsulnt Based on Polyolefin SOLAR ASCE High PID Resistant Cross-Linked Encapsulnt Based on Polyolefin SOLAR ASCE Presented at the PV Module ...

  3. Other Links | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Other Links Project Assessment (OPA) OPA Home About Project Management SC Projects Other Links SC Federal Project Directors (FPD) and FPD Resources Contact Information Project ...

  4. Cross-linked structure of network evolution

    SciTech Connect (OSTI)

    Bassett, Danielle S.; Wymbs, Nicholas F.; Grafton, Scott T.; Porter, Mason A.; Mucha, Peter J.

    2014-03-15

    We study the temporal co-variation of network co-evolution via the cross-link structure of networks, for which we take advantage of the formalism of hypergraphs to map cross-link structures back to network nodes. We investigate two sets of temporal network data in detail. In a network of coupled nonlinear oscillators, hyperedges that consist of network edges with temporally co-varying weights uncover the driving co-evolution patterns of edge weight dynamics both within and between oscillator communities. In the human brain, networks that represent temporal changes in brain activity during learning exhibit early co-evolution that then settles down with practice. Subsequent decreases in hyperedge size are consistent with emergence of an autonomous subgraph whose dynamics no longer depends on other parts of the network. Our results on real and synthetic networks give a poignant demonstration of the ability of cross-link structure to uncover unexpected co-evolution attributes in both real and synthetic dynamical systems. This, in turn, illustrates the utility of analyzing cross-links for investigating the structure of temporal networks.

  5. Linked-View Parallel Coordinate Plot Renderer

    Energy Science and Technology Software Center (OSTI)

    2011-06-28

    This software allows multiple linked views for interactive querying via map-based data selection, bar chart analytic overlays, and high dynamic range (HDR) line renderings. The major component of the visualization package is a parallel coordinate renderer with binning, curved layouts, shader-based rendering, and other techniques to allow interactive visualization of multidimensional data.

  6. Thiazolothiazole-linked porous organic polymers

    SciTech Connect (OSTI)

    Zhu, Xiang; Tian, Chengcheng; Jin, Tian; Wang, Jitong; Mahurin, Shannon Mark; Mei, Wenwen; Xiong, Yan; Hu, Jun; Feng, Xinliang; Liu, Honglai; Dai, Sheng

    2014-10-07

    In this study, thiazolothiazole-linked porous organic polymers have been synthesized from a facile catalyst-free condensation reaction between aldehydes and dithiooxamide under solvothermal conditions. The resultant porous frameworks exhibit a highly selective uptake of CO2 over N2 under ambient conditions.

  7. Thiazolothiazole-linked porous organic polymers

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zhu, Xiang; Tian, Chengcheng; Jin, Tian; Wang, Jitong; Mahurin, Shannon Mark; Mei, Wenwen; Xiong, Yan; Hu, Jun; Feng, Xinliang; Liu, Honglai; et al

    2014-10-07

    In this study, thiazolothiazole-linked porous organic polymers have been synthesized from a facile catalyst-free condensation reaction between aldehydes and dithiooxamide under solvothermal conditions. The resultant porous frameworks exhibit a highly selective uptake of CO2 over N2 under ambient conditions.

  8. Highly cross-linked nanoporous polymers

    DOE Patents [OSTI]

    Steckle, W.P. Jr.; Apen, P.G.; Mitchell, M.A.

    1998-01-20

    Condensation polymerization followed by a supercritical extraction step can be used to obtain highly cross-linked nanoporous polymers with high surface area, controlled pore sizes and rigid structural integrity. The invention polymers are useful for applications requiring separation membranes. 1 fig.

  9. Link failure detection in a parallel computer

    DOE Patents [OSTI]

    Archer, Charles J.; Blocksome, Michael A.; Megerian, Mark G.; Smith, Brian E.

    2010-11-09

    Methods, apparatus, and products are disclosed for link failure detection in a parallel computer including compute nodes connected in a rectangular mesh network, each pair of adjacent compute nodes in the rectangular mesh network connected together using a pair of links, that includes: assigning each compute node to either a first group or a second group such that adjacent compute nodes in the rectangular mesh network are assigned to different groups; sending, by each of the compute nodes assigned to the first group, a first test message to each adjacent compute node assigned to the second group; determining, by each of the compute nodes assigned to the second group, whether the first test message was received from each adjacent compute node assigned to the first group; and notifying a user, by each of the compute nodes assigned to the second group, whether the first test message was received.

  10. Related Links | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Related Links NNSA Lab Directed Research and Development (LDRD) Lab Directed Research and Development Collaborations DOE Adanced Scientific Computing Research DTRA (Defense Threat Reduction Agency) NAS (National Academy of Sciences) NSF (National Science Foundation) DOD (Department of Defense) NASA Exascale Activities NNSA Exascale Environment Planning Workshop ASCR Co-Design Centers Supercomputing Top 500 List ASC at Supercomputing Conference General Information ASC at the Labs How ASC Supports

  11. Links | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Links NNSA HQ National Nuclear Security Administration Advanced Simulation & Computing NNSA Graduate Program NNSA Small Business Program Office of Defense Nuclear Nonproliferation Field Offices NNSA Albuquerque Complex Kansas City Field Office Livermore Field Office Los Alamos Field Office Naval Reactors Idaho Branch Office Nevada Field Office Sandia Field Office DOE Oak Ridge Sites Oak Ridge Office Oak Ridge National Laboratory UCOR Oak Ridge Institute for Science and Education Oak Ridge

  12. Linking Legacies F2002-00544

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Linking Legacies F2002-00544 Fizeau. This 11-kiloton atmospheric nuclear explosion, code-named "Fizeau," was one of 210 atmospheric nuclear tests conducted by the United States. Of the 1,054 nuclear tests explosions conducted by the U.S., 904 were detonated at the Nevada Test Site. All U.S. nuclear explosions since 1962 have been underground. Event Fizeau, Operation Plumbbob, Yucca Flat, Nevada Test Site, Neuada. 9:45 A.M., September 14, 1957. Barrels of transuranic waste sit on a

  13. Compiling and Linking | Argonne Leadership Computing Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cooley Policies Documentation Feedback Please provide feedback to help guide us as we continue to build documentation for our new computing resource. [Feedback Form] Compiling and Linking Compilers and MPI GNU compilers are installed and are available in your default environment. Intel compilers (intel-cc and intel-fc) are installed in /soft/apps. The current version is 11.0; add the key "+intel-11.0" to your .softenvrc file to use them. Multiple MPI versions are available, controlled

  14. External Links | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    External Links Budget Budget Home About Budget by Program GAO Audit Reports External Links Contact Information Budget U.S. Department of Energy SC-41/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3541 F: (301) 903-9524 More Information » External Links Print Text Size: A A A FeedbackShare Page Office of Management and Budget (OMB) External link OMB Budget Documents External link CFO Budget Office U.S. Senate External link U.S. House of Representatives External

  15. Widget:LinkedInCompany | Open Energy Information

    Open Energy Info (EERE)

    allows you to add LinkedIn company widget to your wiki page. For example For nameGoogle: Widget:LinkedInCompany | nameGoogle Retrieved from "http:en.openei.orgw...

  16. Nippon Yusen KK NYK Link | Open Energy Information

    Open Energy Info (EERE)

    Link Jump to: navigation, search Name: Nippon Yusen KK (NYK Link) Place: Tokyo, Tokyo, Japan Zip: 100-0005 Sector: Solar Product: Logistics and shipping company moving to use...

  17. Texas River Authority Website Links | Open Energy Information

    Open Energy Info (EERE)

    Legal Document- OtherOther: Texas River Authority Website LinksLegal Abstract The Texas Parks and Wildlife Department provides information on and links to each of the 23 river...

  18. A New Link Between Human and Bacterial Signaling Machinery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A New Link Between Human and Bacterial Signaling Machinery A New Link Between Human and Bacterial Signaling Machinery Print Tuesday, 19 August 2014 10:34 The human immune system...

  19. Template:FilePreviewDirectLink | Open Energy Information

    Open Energy Info (EERE)

    link to the actual asset instead of the file page about the asset. Parameters file - e.g. "LEDSGPslides.pdf" Usage Link to an OpenEI page (standard functionality)....

  20. LAC Regional Platform Workshop Links | Open Energy Information

    Open Energy Info (EERE)

    Announcement Agenda Participant Package Accommodations Location & Transportation Insurance & Visas Participants Presentations Outcomes Report Links Contact Us One Page Event...

  1. Conservation Standards Enforcement: Useful Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Useful Links Conservation Standards Enforcement: Useful Links This page provides a variety of links to help manufacturers fulfill their compliance obligations under the energy conservation standards program for consumer products and industrial equipment. Under the applicable law (42 U.S.C. 6291-6317), an importer is a manufacturer; therefore, any material you read in the links below that references a "manufacturer" also applies to an importer. Certification Compliance Management System

  2. NICS report links VOCs to respiratory problems

    SciTech Connect (OSTI)

    Kirschner, E.

    1992-04-22

    Children who live near the chemical plants of Kanawha Valley, WV, suffer more acute and chronic respiratory aliments than those farther away, says a Harvard University School of Public Health report. In the $1-million, five-year study commissioned by the National Institute for Chemical Studies (NICS:Charleston, WV) and funded by the Environmental Protection Agency, proximity to chemical plants that emit volatile organic compounds (VOCs) was linked to higher incidence of asthma, acute eye irritation, shortness of breath, and chronic cough. The researchers say they adjusted for most other factors, such as parental smoking and petroleum. {open_quotes}The research hypothesis was whether children in the valley had more symptoms,{close_quotes} says NICS president Paul Hill. {open_quotes}Yes, there is a difference.{close_quotes} The study showed that some ailments were up to 28% more prevalent in children in the valley than in other Kanawha County children.

  3. Link error from craype/2.5.0

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Link error from craype/2.5.0 Link error from craype/2.5.0 January 13, 2016 by Woo-Sun Yang If you build a code using a file called 'configure' with craype/2.5.0, Cray build-tools assumes that you want to use the 'native' link mode (e.g., gcc defaults to dynamic linking), by adding '-Wl,-rpath=/opt/intel/composer_xe_2015/compiler/lib/intel64 -lintlc'. This creates a link error: /usr/bin/ld: cannot find -lintlc A temporary work around is to swap the default craype (2.5.0) with an older or newer

  4. Frequency Stabilization in Non-linear MEMS and NEMS Oscillators...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    allows creating micro and nano mechanical oscillators with excellent frequency stability. ... A team of Argonne scientists has developed a method to make the micronano oscillators ...

  5. Availability of the National Energy Modeling System (NEMS) Archive

    Gasoline and Diesel Fuel Update (EIA)

    19 Table 6 Created on: 8/27/2016 11:18:10 AM Table 6. Gross withdrawals of natural gas in selected states and the Federal Gulf of Mexico, 2011-2016 (million cubic feet) Year and Month Alaska Arkansas California Colorado Kansas Louisiana Montana New Mexico North Dakota Ohio 2011 Total 3,162,922 1,076,757 279,130 1,649,306 309,952 3,040,523 79,506 1,287,682 157,025 78,858 2012 Total 3,164,791 1,146,168 246,822 1,709,376 296,299 2,955,437 66,954 1,276,296 258,568 84,482 2013 Total 3,215,358

  6. Natural Gas Transmission and Distribution Module - NEMS Documentation

    Reports and Publications (EIA)

    2014-01-01

    Documents the archived version of the Natural Gas Transmission and Distribution Model that was used to produce the natural gas forecasts used in support of the Annual Energy Outlook 2014.

  7. Modeling Distributed Electricity Generation in the NEMS Buildings Models

    Reports and Publications (EIA)

    2011-01-01

    This paper presents the modeling methodology, projected market penetration, and impact of distributed generation with respect to offsetting future electricity needs and carbon dioxide emissions in the residential and commercial buildings sector in the Annual Energy Outlook 2000 (AEO2000) reference case.

  8. Analysis and Representation of Miscellaneous Electric Loads in NEMS -

    U.S. Energy Information Administration (EIA) Indexed Site

    Energy Information Administration Analysis & Projections Glossary › FAQS › Overview Projection Data Monthly short-term forecasts to 2016 Annual projections to 2040 International projections All projections reports Analysis & Projections Major Topics Most popular Annual Energy Outlook related Congressional & other requests International Energy Outlook related Presentations Recurring Short-Term Outlook Related Special outlooks Testimony All reports Browse by Tag Alphabetical

  9. U.S. Energy Information Administration NEMS Residential Demand...

    Gasoline and Diesel Fuel Update (EIA)

    Geothermal Heat Pump Natural Gas Heat Pump Variables: HSYSSHR 200678,eg,b,r Benchmarking Data from Short-Term Energy Outlook Definition: Housing unit energy consumption by...

  10. Frequency stabilization in nonlinear MEMS and NEMS oscillators

    DOE Patents [OSTI]

    Lopez, Omar Daniel; Antonio, Dario

    2014-09-16

    An illustrative system includes an amplifier operably connected to a phase shifter. The amplifier is configured to amplify a voltage from an oscillator. The phase shifter is operably connected to a driving amplitude control, wherein the phase shifter is configured to phase shift the amplified voltage and is configured to set an amplitude of the phase shifted voltage. The oscillator is operably connected to the driving amplitude control. The phase shifted voltage drives the oscillator. The oscillator is at an internal resonance condition, based at least on the amplitude of the phase shifted voltage, that stabilizes frequency oscillations in the oscillator.

  11. Microwaves and particle accelerators: a fundamental link

    SciTech Connect (OSTI)

    Chattopadhyay, Swapan

    2011-07-01

    John Cockcroft's splitting of the atom and Ernest Lawrence's invention of the cyclotron in the first half of the twentieth century ushered in the grand era of ever higher energy particle accelerators to probe deeper into matter. It also forged a link, bonding scientific discovery with technological innovation that continues today in the twenty first century. The development of radar and high power vacuum electronics, especially microwave power tubes like the magnetrons and the klystrons in the pre-second world war era, was instrumental in the rapid development of circular and linear charged particle accelerators in the second half of the twentieth century. We had harnessed the powerful microwave radio-frequency sources from few tens of MHz to up to 90 GHz spanning L-band to W-band frequencies. Simultaneously in the second half of the twentieth century, lasers began to offer very first opportunities of controlling charged particles at smaller resolutions on the scale of wavelengths of visible light. We also witnessed in this period the emergence of the photon and neutron sciences driven by accelerators built-by-design producing tailored and ultra-bright pulses of bright photons and neutrons to probe structure and function of matter from aggregate to individual molecular and atomic scales in unexplored territories in material and life sciences. As we enter the twenty first century, the race for ever higher energies, brightness and luminosity to probe atto-metric and atto-second domains of the ultra-small structures and ultra-fast processes continues. These developments depend crucially on yet further advancements in the production and control of high power and high frequency microwaves and light sources, often intricately coupled in their operation to the high energy beams themselves. We give a glimpse of the recent developments and innovations in the electromagnetic production and control of charged particle beams in the service of science and society. (author)

  12. Fusion Links | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fusion Links Fusion Energy Sciences (FES) FES Home About Research Fusion Institutions Fusion Links International Activities Facilities Science Highlights Benefits of FES Funding Opportunities Fusion Energy Sciences Advisory Committee (FESAC) Community Resources Contact Information Fusion Energy Sciences U.S. Department of Energy SC-24/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-4941 F: (301) 903-8584 E: Email Us More Information » Research Fusion Links Print

  13. Radiation Effects Research Foundation Links Past and Future | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Effects Research Foundation Links Past and Future Radiation Effects Research Foundation Links Past and Future August 2009 This document provides historical information about the Radiation Effects Research Foundation and its core research activities. Radiation Effects Research Foundation Links Past and Future (195.71 KB) More Documents & Publications Report of the Blue Ribbon Panel on the Review of the Radiation Effects Research Foundation Commemoration of the 60th Annniversary of

  14. Exploring the Business Link Opportunity: Transmission & Clean Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Development in the West | Department of Energy Exploring the Business Link Opportunity: Transmission & Clean Energy Development in the West Exploring the Business Link Opportunity: Transmission & Clean Energy Development in the West February 7-8, 2012 Image of a speaker at the forum. Denver, Colorado Sheraton Denver Downtown Hotel The Tribal Leader Energy Forum, "Exploring the Business Link Opportunity: Transmission & Clean Energy Development in the West, " co-sponsored

  15. Fuel Cell Technologies Manufacturing Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Manufacturing » Fuel Cell Technologies Manufacturing Related Links Fuel Cell Technologies Manufacturing Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded fuel cell technologies manufacturing activities, other EERE and federal manufacturing activities and initiatives, research plans and roadmaps, workshops, and additional related links. DOE-Funded Fuel Cell Technologies Manufacturing Activities Each year, hydrogen and fuel cell projects funded by

  16. Employment at EERE Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    » Employment at EERE Related Links Employment at EERE Related Links If you are considering employment with the U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE), and even if you already are an EERE employee, you may find the following links helpful: Veterans' Employment Resources The American's Veteran site includes information to help you understand veterans' preference, how federal jobs are filled, and unique veteran appointing authorities designed to

  17. Compiling and Linking FAQ | Argonne Leadership Computing Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Overview of How to Compile and Link Example Program and Makefile for BG/Q How to Manage Threading bgclang Compiler Compiling and Linking FAQ Queueing & Running Jobs Data Transfer Debugging & Profiling Performance Tools & APIs Software & Libraries IBM References Cooley Policies Documentation Feedback Please provide feedback to help guide us as we continue to build documentation for our new computing resource. [Feedback Form] Compiling and Linking FAQ Contents Where do I find

  18. California/Transmission/Agency Links | Open Energy Information

    Open Energy Info (EERE)

    State Agency Links California Department of Fish and Wildlife California Office of Historic Preservation California Department of Transportation California Department of...

  19. Idaho/Transmission/Agency Links | Open Energy Information

    Open Energy Info (EERE)

    State Agency Links Idaho Department of Fish and Game Idaho State Historical Society Idaho Department of Environmental Quality Idaho Transportation Department Idaho Department of...

  20. Final Progress Report for Linking Ion Solvation and Lithium Battery

    Office of Scientific and Technical Information (OSTI)

    for Linking Ion Solvation and Lithium Battery Electrolyte Properties Henderson, Wesley 25 ENERGY STORAGE battery, electrolyte, solvation, ionic association battery, electrolyte,...

  1. LEDS Collaboration in Action Workshop Links | Open Energy Information

    Open Energy Info (EERE)

    LEDS Collaboration in Action Workshop Links Jump to: navigation, search Low Emission Development Strategies Global Partnership Advancing climate-resilient, low-emission development...

  2. Final New England Clean Power Link Project Environmental Impact...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (http:wamcfilesstylesdefaultpublic201410new-england-clean-power-link- ... Response Document Department of Energy October 2015 i Table of Contents 1 ...

  3. WAFER TEST CAVITY -Linking Surface Microstructure to RF Performance...

    Office of Scientific and Technical Information (OSTI)

    WAFER TEST CAVITY -Linking Surface Microstructure to RF Performance: a 'Short--Sample Test Facility' for characterizing superconducting materials for SRF cavities. Citation Details ...

  4. AEC Experiment Establishes Computer Link Between California and...

    Office of Scientific and Technical Information (OSTI)

    in Paris could search a computer in California and display the resulting bibliographic ... AEC EXPERIMENT ESTABLISHES COMPUTER LINK BETWEEN CALIFORNIA AND PARIS The feasibility of a ...

  5. Other EEOICP Links and Previous Federal Register Notices | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Health (NIOSH), Office of Compensation Analysis and Support (OCAS) NIOSH performs dose ... Linking Legacies - the story of the creation and development of the U.S. nuclear ...

  6. An Allosteric Interaction Links USP7 to Deubiquitination and...

    Office of Scientific and Technical Information (OSTI)

    Title: An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1 Authors: Zhang, Zhi-Min ; Rothbart, Scott B. ; Allison, David F. ; Cai, Qian ; ...

  7. EIS-0503: New England Clean Power Link, Vermont | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Power Company substation in Cavendish, VT. EIS-0503: New England Clean Power Link, Vermont Public Comment Opportunities No public comment opportunities available at this time. ...

  8. Linking Network Microstructure to Macroscopic Properties of Siloxane...

    Office of Scientific and Technical Information (OSTI)

    Title: Linking Network Microstructure to Macroscopic Properties of Siloxane Elastomers Using Combined Nuclear Magnetic Resonance and Mesoscale Computational Modeling Authors: Mayer...

  9. Linking Network Microstructure to Macroscopic Properties of Siloxane

    Office of Scientific and Technical Information (OSTI)

    Elastomers Using Combined Nuclear Magnetic Resonance and Mesoscale Computational Modeling (Journal Article) | SciTech Connect Journal Article: Linking Network Microstructure to Macroscopic Properties of Siloxane Elastomers Using Combined Nuclear Magnetic Resonance and Mesoscale Computational Modeling Citation Details In-Document Search Title: Linking Network Microstructure to Macroscopic Properties of Siloxane Elastomers Using Combined Nuclear Magnetic Resonance and Mesoscale Computational

  10. Enzyme linked immunoassay with stabilized polymer saccharide enzyme conjugates

    DOE Patents [OSTI]

    Callstrom, M.R.; Bednarski, M.D.; Gruber, P.R.

    1997-11-25

    An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate comprises the enzyme which is linked to the polymer at multiple points through saccharide linker groups. 19 figs.

  11. Enzyme linked immunoassay with stabilized polymer saccharide enzyme conjugates

    DOE Patents [OSTI]

    Callstrom, Matthew R. (Columbus, OH); Bednarski, Mark D. (Berkeley, CA); Gruber, Patrick R. (St. Paul, MN)

    1997-01-01

    An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate comprises the enzyme which is linked to the polymer at multiple points through saccharide linker groups.

  12. Recent content in Linked Open Data Workshop in Washington, D...

    Open Energy Info (EERE)

    Recent content in Linked Open Data Workshop in Washington, D.C. Home Name Post date sort icon Type Detailed Planning Kicks Off Jweers 27 Sep 2012 - 06:53 Blog entry Notes from the...

  13. Reference Linking at the DOE Office of Scientific and Technical...

    Office of Scientific and Technical Information (OSTI)

    Reference Linking at the DOE Office of Scientific and Technical Information The usefulness of electronic R&D reports, such as those accessed via the DOE Information Bridge, is ...

  14. Mach-Zehnder Fiber-Optic Links for ICF Diagnostics

    SciTech Connect (OSTI)

    Miller, E. K., Hermann, H. W.

    2012-11-01

    This article describes the operation and evolution of Mach-Zehnder links for single-point detectors in inertial confinement fusion experimental facilities, based on the Gamma Reaction History (GRH) diagnostic at the National Ignition Facility.

  15. Property:Incentive/Auth5Link | Open Energy Information

    Open Energy Info (EERE)

    "IncentiveAuth5Link" Showing 25 pages using this property. (previous 25) (next 25) A Alternative Energy Portfolio Standard (Pennsylvania) + http:www.puc.state.pa.usPcDocs...

  16. Widget:ExternalLinkButton | Open Energy Information

    Open Energy Info (EERE)

    with spaces (i.e.- btn-primary) style - add style elements, cannot change button color with this (optional) Examples Default Button Visit FWA Widget:ExternalLinkButton |...

  17. Mechanism of DNA interstrand cross-link processing by repair...

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Search Results Journal Article: Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1 Citation Details In-Document Search Title: Mechanism of ...

  18. Giant magnetic effects and oscillations in antiferromagnetic Josephson weak links

    SciTech Connect (OSTI)

    Gorkov, L.; Kresin, Vladimir

    2001-04-01

    Josephson junctions with an antiferromagnetic metal as a link are described. The junction can be switched off by a relatively small magnetic field. The amplitude of the current oscillates as a function of the field.

  19. Overview of How to Compile and Link | Argonne Leadership Computing...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    code for the BGQ system is too complex to cover in this document. What follows is a brief summary. All compile and link procedures are performed on login nodes with a ...

  20. IDENTIFYING GENES CONTROLLING FERULATE CROSS-LINKING FORMATION...

    Office of Scientific and Technical Information (OSTI)

    of cross-linking and in turn impact biomass utility for forage and biofuel production. ... gene in the cell wall of maize or other biofuel crops, aiming to improve their ...

  1. Reference Links | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Print Text Size: A A A FeedbackShare Page FOIA, 5 U.S.C. Sec. 552, As Amended by Public Law No. 104-231, 110 Stat. 2422 External link DOE Implementing Regulations, 10 CFR 1004 ...

  2. OpenEI and Linked Open Data | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    OpenEI and Linked Open Data OpenEI and Linked Open Data OpenEI presentation by Jon Weers and Kate Young at the Geothermal Technologies Office 2013 Annual Peer Review in Colorado. openei_peerreview2013.pdf (4.95 MB) More Documents & Publications Web Coordinator Meetings - October 2014 Fueling Innovation and Adoption by Sharing Data on the DOE Geothermal Data Repository National Geothermal Data System (NGDS) Fact Sheet

  3. Linking Legacies: Connecting the Cold War Nuclear Weapons Production

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Processes to Their Environmental Consequences | Department of Energy Linking Legacies: Connecting the Cold War Nuclear Weapons Production Processes to Their Environmental Consequences Linking Legacies: Connecting the Cold War Nuclear Weapons Production Processes to Their Environmental Consequences This report described each step in the cycle of nuclear weapons production and defined for the first time a planned disposition path for all waste streams generated prior to 1992 as a result of

  4. Welcome to the First Issue of AlumniLink

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Welcome to the Cultural Resources Newsletter Welcome to the Cultural Resources Newsletter Welcome to the Cultural Resources Newsletter (446.29 KB) More Documents & Publications Secretary Directs FPO to Prepare Strategic Plan Strategic Plan Submitted to the Secretary Microsoft Word - August06.doc

    Welcome to the First Issue of AlumniLink Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Welcome to the First Issue

  5. Final Progress Report for Linking Ion Solvation and Lithium Battery

    Office of Scientific and Technical Information (OSTI)

    Electrolyte Properties (Technical Report) | SciTech Connect Progress Report for Linking Ion Solvation and Lithium Battery Electrolyte Properties Citation Details In-Document Search Title: Final Progress Report for Linking Ion Solvation and Lithium Battery Electrolyte Properties The research objective of this proposal was to provide a detailed analysis of how solvent and anion structure govern the solvation state of Li+ cations in solvent-LiX mixtures and how this, in turn, dictates the

  6. IDENTIFYING GENES CONTROLLING FERULATE CROSS-LINKING FORMATION IN GRASS

    Office of Scientific and Technical Information (OSTI)

    CELL WALLS (Technical Report) | SciTech Connect IDENTIFYING GENES CONTROLLING FERULATE CROSS-LINKING FORMATION IN GRASS CELL WALLS Citation Details In-Document Search Title: IDENTIFYING GENES CONTROLLING FERULATE CROSS-LINKING FORMATION IN GRASS CELL WALLS DESCRIPTION/ABSTRACT This proposal focuses on cell wall feruloylation and our long term goal is to identify and isolate novel genes controlling feruloylation and to characterize the phenotype of mutants in this pathway, with a spotlight on

  7. Uniform Methods Project Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Project Related Links Uniform Methods Project Related Links The websites and publications listed below provide supporting information for the Uniform Methods Project and for evaluation, measurement, and verification (EM&V) of energy efficiency programs. Glossaries of EM&V Terms Federal EM&V Resources International Resources Related Standards Glossaries of EM&V Terms The following glossaries provide definitions of technical language and EM&V terms. Appendix A: Glossary of

  8. EIA - Natural Gas Pipeline Network - Regional Overview and Links

    U.S. Energy Information Administration (EIA) Indexed Site

    Overview and Links About U.S. Natural Gas Pipelines - Transporting Natural Gas based on data through 2007/2008 with selected updates Regional Overviews and Links to Pipeline Companies Through a series of interconnecting interstate and intrastate pipelines the transportation of natural gas from one location to another within the United States has become a relatively seamless operation. While intrastate pipeline systems often transports natural gas from production areas directly to consumers in

  9. Reference Links | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reference Links Integrated Support Center (ISC) ISC Home About Services Freedom of Information Act (FOIA) Privacy Act Compilation of Systems of Records Energy Employees Occupational Illness Compensation Program Act (EEOICPA) How to Submit a Privacy Act Request Reference Links NEPA Documents Contact Information Integrated Support Center Roxanne Purucker U.S. Department of Energy 9800 S. Cass Avenue Argonne, IL 60439 P: (630) 252-2110 Kenneth Tarcza U.S. Department of Energy 200 Administration

  10. CT Scan of Earth Links Mantle Plumes with Volcanic Hotspots

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CT Scan of Earth Links Mantle Plumes with Volcanic Hotspots CT Scan of Earth Links Mantle Plumes with Volcanic Hotspots Simulations Run at NERSC Show How Seismic Waves Travel Through Mantle September 2, 2015 Robert Sanders, rlsanders@berkeley.edu, (510) 643-6998 NERSC PI: Barbara Romanowicz Lead Institution: University of California, Berkeley Project Title: Imaging and Calibration of Mantle Structure at Global and Regional Scales Using Full-Waveform Seismic Tomography NERSC Resources Used:

  11. Montana Coalbed Methane Production (Billion Cubic Feet)

    Gasoline and Diesel Fuel Update (EIA)

    Model Documentation Report: Macroeconomic Activity Module (MAM) of the National Energy Modeling System May 2014 Independent Statistics & Analysis www.eia.gov U.S. Department of Energy Washington, DC 20585 U.S. Energy Information Administration | NEMS Macroeconomic Activity Module Documentation Report i This report was prepared by the U.S. Energy Information Administration (EIA), the statistical and analytical agency within the U.S. Department of Energy. By law, EIA's data, analyses, and

  12. The versatile link, a common project for super-LHC

    SciTech Connect (OSTI)

    Amaral, Luis; Dris, Stefanos; Gerardin, Alexandre; Huffman, Todd; Issever, Cigdem; Pacheco, Alberto Jimenez; Jones, Mark; Kwan, Simon; Lee, Shih-Chang; Lian, Zhijun; Liu, Tiankuan; /CERN /Oxford U. /Fermilab /Taipei, Computing Ctr. /Southern Methodist U.

    2009-07-01

    Radiation tolerant, high speed optoelectronic data transmission links are fundamental building blocks in today's large scale High Energy Physics (HEP) detectors, as exemplified by the four experiments currently under commissioning at the Large Hadron Collider (LHC), see for example. New experiments or upgrades will impose even more stringent demands on these systems from the point of view of performance and radiation tolerance. This can already be seen from the developments underway for the Super Large Hadron Collider (SLHC) project, a proposed upgrade to the LHC aiming at increasing the luminosity of the machine by factor of 10 to 10{sup 35} cm{sup -2}s{sup -1}, and thus providing a better chance to see rare processes and improving statistically marginal measurements. In the past, specific data transmission links have been independently developed by each LHC experiment for data acquisition (DAQ), detector control as well as trigger and timing distribution (TTC). This was justified by the different types of applications being targeted as well as by technological limitations preventing one single solution from fitting all requirements. However with today's maturity of optoelectronic and CMOS technologies it is possible to envisage the development of a general purpose optical link which can cover most transmission applications: a Versatile Link. Such an approach has the clear advantage of concentrating the development effort on one single project targeting an optical link whose final functionality will only result from the topology and configuration settings adopted.

  13. Linked Open Data Workshop in Washington, D.C. | OpenEI Community

    Open Energy Info (EERE)

    Linked Open Data Workshop in Washington, D.C. Home > Linked Open Data Workshop in Washington, D.C. > Posts by term > Linked Open Data Workshop in Washington, D.C. Content Group...

  14. New England Clean Power Link Project Environmental Impact Statement

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    FINAL NEW ENGLAND CLEAN POWER LINK PROJECT ENVIRONMENTAL IMPACT STATEMENT DOE/EIS-0503 SUMMARY U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY COOPERATING AGENCIES U.S. ENVIRONMENTAL PROTECTION AGENCY U.S. ARMY CORPS OF ENGINEERS U.S. COAST GUARD OCTOBER 2015 This Page Intentionally Left Blank Final New England Clean Power Link EIS U.S. Department of Energy October 2015 i COVER SHEET RESPONSIBLE FEDERAL AGENCY U.S. Department of Energy (DOE), Office of

  15. New England Clean Power Link Project Final Environmental Impact Statement

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Credits 1. TDI-NE (http://wamc/files/styles/default/public/201410/new-england-clean-power-link-map-ctsy- tdi-new-england.jpg" alt="">) 2. NECPL exit from Lake Champlain (Benson, Vermont) courtesy of TDI-NE 3. Lake Bomoseen, Fair Haven, Vermont courtesy of TDI-NE 4. TDI-NE 2014a 1 3 2 4 FINAL NEW ENGLAND CLEAN POWER LINK PROJECT ENVIRONMENTAL IMPACT STATEMENT DOE/EIS-0503 VOLUME II: APPENDICES U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY

  16. Useful Links for Small Businesses | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Useful Links for Small Businesses Useful Links for Small Businesses Business USA A product of collective thoughts and inputs from the following agencies who have pledged their commitment to making this site a one-stop shop for everything related to business in the USA. Electronic Subcontracting Reporting System (eSRS) This is the official site for the electronic Subcontracting Reporting System (eSRS). The use of eSRS promises to create higher visibility and introduce a more transparency into the

  17. Fault isolation through no-overhead link level CRC

    DOE Patents [OSTI]

    Chen, Dong; Coteus, Paul W.; Gara, Alan G.

    2007-04-24

    A fault isolation technique for checking the accuracy of data packets transmitted between nodes of a parallel processor. An independent crc is kept of all data sent from one processor to another, and received from one processor to another. At the end of each checkpoint, the crcs are compared. If they do not match, there was an error. The crcs may be cleared and restarted at each checkpoint. In the preferred embodiment, the basic functionality is to calculate a CRC of all packet data that has been successfully transmitted across a given link. This CRC is done on both ends of the link, thereby allowing an independent check on all data believed to have been correctly transmitted. Preferably, all links have this CRC coverage, and the CRC used in this link level check is different from that used in the packet transfer protocol. This independent check, if successfully passed, virtually eliminates the possibility that any data errors were missed during the previous transfer period.

  18. Adding Links in Energy.gov Content Management System | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy.gov Content Management System » Adding Links in Energy.gov Content Management System Adding Links in Energy.gov Content Management System For Office of Energy Efficiency and Renewable Energy (EERE) websites, to add a link in the Energy.gov Drupal content management system (CMS), follow these steps: Edit the page (also called a node) that you want to add a link to. Select the text you want to link. Click the "Link" button. Then: If you are linking to a page on Energy.gov, select

  19. Laser Safety Method For Duplex Open Loop Parallel Optical Link

    DOE Patents [OSTI]

    Baumgartner, Steven John; Hedin, Daniel Scott; Paschal, Matthew James

    2003-12-02

    A method and apparatus are provided to ensure that laser optical power does not exceed a "safe" level in an open loop parallel optical link in the event that a fiber optic ribbon cable is broken or otherwise severed. A duplex parallel optical link includes a transmitter and receiver pair and a fiber optic ribbon that includes a designated number of channels that cannot be split. The duplex transceiver includes a corresponding transmitter and receiver that are physically attached to each other and cannot be detached therefrom, so as to ensure safe, laser optical power in the event that the fiber optic ribbon cable is broken or severed. Safe optical power is ensured by redundant current and voltage safety checks.

  20. Real time markerless motion tracking using linked kinematic chains

    DOE Patents [OSTI]

    Luck, Jason P.; Small, Daniel E.

    2007-08-14

    A markerless method is described for tracking the motion of subjects in a three dimensional environment using a model based on linked kinematic chains. The invention is suitable for tracking robotic, animal or human subjects in real-time using a single computer with inexpensive video equipment, and does not require the use of markers or specialized clothing. A simple model of rigid linked segments is constructed of the subject and tracked using three dimensional volumetric data collected by a multiple camera video imaging system. A physics based method is then used to compute forces to align the model with subsequent volumetric data sets in real-time. The method is able to handle occlusion of segments and accommodates joint limits, velocity constraints, and collision constraints and provides for error recovery. The method further provides for elimination of singularities in Jacobian based calculations, which has been problematic in alternative methods.

  1. Exploring Competing Kinetic Processes in Quantum Dots Linked to Electrode

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Surfaces | MIT-Harvard Center for Excitonics Competing Kinetic Processes in Quantum Dots Linked to Electrode Surfaces March 14, 2012 at 2:30pm/4-349 Mark Hybertsen Brookhaven National Laboratory, Columbia University Mark_Hybertsen001_000 Abstract: Exploiting the unique properties of nanostructured chromophores for light harvesting applications relies on the balance between competing kinetic processes including energy transfer, carrier relaxation and carrier tunneling. In the first part of

  2. Privacy Act Links to Related Sites | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration | (NNSA) Links to Related Sites The Privacy Act of 1974 (Title 5, United States Code, Section 552a). The Federal Register is the official daily publication for Rules, Proposed Rules, and Notices of Federal agencies and organizations, as well as Executive Orders and other Presidential Documents. The Privacy Act Issuances Compilation contains descriptions of Federal agency systems of records maintained on individuals and rules agencies follow to assist individuals who request

  3. References & Links | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    References & Links 48CFR Chapter 9, Acquisition Regulation (DEAR) Department of Energy Acquisition Requirements (DEAR) DOE Order 470.4B, Safeguards and Security Program DOE Order 472.2, Personnel Security DOE Order 206.2 DOE Order 470.4B Executive Order 10865 Executive Order 12968 Federal Acquisition Regulation (FAR) Federal Bureau of Investigations FIPS PUB 201-2, Personal Identity Verification (PIV) of Federal Employees and Contractors Intelligence Reform and Terrorism Prevention Act of

  4. Links | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Links NNSA HQ National Nuclear Security Administration Advanced Simulation & Computing NNSA Graduate Program NNSA Small Business Program Office of Defense Nuclear Nonproliferation Field Offices NNSA Albuquerque Complex Kansas City Field Office Livermore Field Office Los Alamos Field Office Naval Reactors Idaho Branch Office Nevada Field Office Sandia Field Office DOE Oak Ridge Sites Oak Ridge Office Oak Ridge National Laboratory UCOR Oak Ridge Institute for Science and Education Oak Ridge

  5. GLAMM: Genome-Linked Application for Metabolic Maps

    SciTech Connect (OSTI)

    Bates, John; Chivian, Dylan; Arkin, Adam

    2011-05-29

    The Genome-Linked Application for Metabolic Maps (GLAMM) is a unified web interface for visualizing metabolic networks, reconstructing metabolic networks from annotated genome data, visualizing experimental data in the context of metabolic networks, and investigating the construction of novel, transgenic pathways. This simple, user-friendly interface is tightly integrated with the comparative genomics tools of MicrobesOnline. GLAMM is available for free to the scientific community at glamm.lbl.gov.

  6. BRCA1-linked marker in postmenopausal breast cancer families

    SciTech Connect (OSTI)

    Folsom, A.R.; Chen, P.L.; Sellers, T.A.

    1994-09-01

    A majority of breast and ovarian cancer families and half of the early-onset breast cancer families are linked to markers on 17q (BRCA1). While linkage has been demonstrated in families with premenopausal disease, few studies have tested these markers in families with postmenopausal breast cancer. In the Iowa Women`s Health Study, a population-based study of over 42,000 women, an association of waist-to-hip ratio (WHR) with the risk of postmenopausal breast cancer was found predominantly in women with a positive family history -- this interaction was associated with a 3.2-fold elevated risk. This effect was even more pronounced when the definition of family history included breast and ovarian cancer, known to be linked to 17q markers. We evaluated evidence for linkage with D17S579, a BRCA-1-linked marker, in 13 families in which the index case had postmenopausal breast cancer. Genotyping for alleles at D17S579 was performed on 84 blood samples. Linkage analysis assumed that the breast cancer trait had an autosomal dominant mode of inheritance with a penetrance of 80%. For the 13 families studied, the maximum lod score was 0.29 at a theta of 0.27. There was significant evidence against tight linkage of breast cancer with D17S579 (theta<0.4). Heterogeneity analysis suggested evidence for the presence of both linked and unlinked families. Partitioning informative families on WHR of the index case suggested heterogeneity. These data suggest that, in a subset of families identified by a postmenopausal breast cancer proband, risk of breast cancer may be mediated by BRCA1, with heterogeneity defined by WHR.

  7. Wideband precision analog telemetry link using digital techniques

    SciTech Connect (OSTI)

    Hearn, W.E.

    1982-10-01

    A highly linear Wideband Analog Fiber Optic Link is described which samples at a 1 MHz rate with 10-bit accuracy and transmits and receives by means of a high speed PDM code. Aliasing and sampling effects are fully suppressed and a nearly Gaussian pulse response is attained with a 2 ..mu..sec risetime. Analog signals are recovered with very low distortion and d.c. drift and a S/N ratio of better than 52 db.

  8. New Guide Helps Industry Link with Department of Energy Labs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Guide Helps Industry Link with Department of Energy Labs For more information contact: George Douglas, 303-275-4096 email: George Douglas Golden, Colo., May. 4, 2001 - Working with U. S. Department of Energy (DOE) laboratories became easier with the recent release of the guide, Doing Business with the Laboratories of the Laboratory Coordinating Council. The guide explains how the DOE's Laboratory Coordinating Council gives U.S. industry access to a "virtual" laboratory that can be

  9. OSTIblog Articles in the reference linking Topic | OSTI, US Dept of Energy

    Office of Scientific and Technical Information (OSTI)

    Office of Scientific and Technical Information reference linking Topic OSTI and Reference Linking by Daphne Evans 13 May, 2008 in Technology OSTI actively supports the practice of Reference Linking. Also referred to as citation linking, reference linking adds value to technical reports and journal articles by hyperlinking the references at the end of the document. Authors frequently cite numerous supporting reports and articles. However, locating these cited works can be difficult. If these

  10. Optical analog data link with simple self-test feature

    DOE Patents [OSTI]

    Witkover, R.L.

    1984-02-01

    A communications circuit for optically transmitting analog data signals free of excessive ripple, while having rapid response time. The invention is further characterized by being adapted to provide an immediate indication of the failure of the optical transmission link of the circuit. Commerically available voltage to frequency converter chips are used in conjunction with suitable wiring arrays and in combination with readily available indicator means for constructing the communication circuit of the invention. A V/F converter in the communications circuit is coupled to an offset adjustment means to cause the converter to continuously produce a string of output voltage pulses having a frequency of about 1Khz responsive to the input analog signal to the converter being zero. The continuous presence of the 1Khz frequency on the optical transmission link is monitored at the receiving end of the communication circuit and the indicator means is connected to immediately provide an easily detected indication of a failure of the optical transmission link to transmit the 1Khz frequency pulses.

  11. Characterization of Gigabit Ethernet Over Highly Turbulent Optical Wireless Links

    SciTech Connect (OSTI)

    Johnson, G W; Cornish, J P; Wilburn, J W; Young, R A; Ruggiero, A J

    2002-07-01

    We report on the performance characterization and issues associated with using Gigabit Ethernet (GigE) over a highly turbulent (C{sub n}{sup 2} > 10{sup -12}) 1.3 km air-optic lasercom links. Commercial GigE hardware is a cost-effective and scalable physical layer standard that can be applied to air-optic communications. We demonstrate a simple GigE hardware interface to a singlemode fiber-coupled, 1550 nm, WDM air-optic transceiver. TCPAP serves as a robust and universal foundation protocol that has some tolerance of data loss due to atmospheric fading. Challenges include establishing and maintaining a connection with acceptable throughput under poor propagation conditions. The most useful link performance diagnostic is shown to be scintillation index, where a value of 0.2 is the maximum permissible for adequate GigE throughput. Maximum GigE throughput observed was 49.7% of that obtained with a fiber jumper when scintillation index is 0.1. Shortcomings in conventional measurements such as bit error rate are apparent. Prospects for forward mor correction and other link enhancements will be discussed.

  12. Optical analog data link with simple self-test feature

    DOE Patents [OSTI]

    Witkover, Richard L.

    1986-01-01

    A communications circuit for optically transmitting analog data signals free of excessive ripple, while having rapid response time. The invention is further characterized by being adapted to provide an immediate indication of the failure of the optical transmission link of the circuit. Commercially available voltage to frequency converter chips are used in conjunction with suitable wiring arrays and in combination with readily available indicator means for constructing the communication circuit of the invention. A V/F converter in the communications circuit is coupled to an offset adjustment means to cause the converter to continuously produce a string of output voltage pulses having a frequency of about 1 Khz responsive to the input analog signal to the converter being zero. The continuous presence of the 1 Khz frequency on the optical transmission link is monitored at the receiving end of the communication circuit and the indicator means is connected to immediately provide an easily detected indication of a failure of the optical transmission link to transmit the 1 Khz frequency pulses.

  13. Parallel optics technology assessment for the versatile link project

    SciTech Connect (OSTI)

    Chramowicz, J.; Kwan, S.; Rivera, R.; Prosser, A.; /Fermilab

    2011-01-01

    This poster describes the assessment of commercially available and prototype parallel optics modules for possible use as back end components for the Versatile Link common project. The assessment covers SNAP12 transmitter and receiver modules as well as optical engine technologies in dense packaging options. Tests were performed using vendor evaluation boards (SNAP12) as well as custom evaluation boards (optical engines). The measurements obtained were used to compare the performance of these components with single channel SFP+ components operating at a transmission wavelength of 850 nm over multimode fibers.

  14. Duality linking standard and tachyon scalar field cosmologies

    SciTech Connect (OSTI)

    Avelino, P. P.; Bazeia, D.; Losano, L.; Oliveira, J. C. R. E.; Pavan, A. B.

    2010-09-15

    In this work we investigate the duality linking standard and tachyon scalar field homogeneous and isotropic cosmologies in N+1 dimensions. We determine the transformation between standard and tachyon scalar fields and between their associated potentials, corresponding to the same background evolution. We show that, in general, the duality is broken at a perturbative level, when deviations from a homogeneous and isotropic background are taken into account. However, we find that for slow-rolling fields the duality is still preserved at a linear level. We illustrate our results with specific examples of cosmological relevance, where the correspondence between scalar and tachyon scalar field models can be calculated explicitly.

  15. DOE and Fusion Links | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOE and Fusion Links United States Department of Energy U.S. Department of Energy Office of Science Office of Fusion Energy Sciences U.S. D.O.E. Princeton Site Office Map showing U.S. Fusion Program Participants U.S. D.O.E. Science Laboratories U.S. D.O.E. User Facilities U.S. D.O.E. Funding Opportunities Other Fusion Research Sites United States Sites General Atomics (GA) MIT Plasma Science and Fusion Center U.S. ITER National Ignition Facility (NIF) American Fusion News International Sites

  16. Techniques in teaching statistics : linking research production and research use.

    SciTech Connect (OSTI)

    Martinez-Moyano, I .; Smith, A.

    2012-01-01

    In the spirit of closing the 'research-practice gap,' the authors extend evidence-based principles to statistics instruction in social science graduate education. The authors employ a Delphi method to survey experienced statistics instructors to identify teaching techniques to overcome the challenges inherent in teaching statistics to students enrolled in practitioner-oriented master's degree programs. Among the teaching techniques identi?ed as essential are using real-life examples, requiring data collection exercises, and emphasizing interpretation rather than results. Building on existing research, preliminary interviews, and the ?ndings from the study, the authors develop a model describing antecedents to the strength of the link between research and practice.

  17. Photo of the Week: Mapping the Link between Invasive Plants and...

    Office of Environmental Management (EM)

    Mapping the Link between Invasive Plants and Wildfire in the Mojave Desert Photo of the Week: Mapping the Link between Invasive Plants and Wildfire in the Mojave Desert August 21, ...

  18. Linked Open Data Workshop in Washington, D.C. | OpenEI Community

    Open Energy Info (EERE)

    Home > Linked Open Data Workshop in Washington, D.C. > Posts by term Content Group Activity By term Q & A Feeds Event (2) linked open data (2) LOD (2) notes (1) Open Data (2)...

  19. Linking the micro and macro: L-H transition dynamics and threshold...

    Office of Scientific and Technical Information (OSTI)

    Linking the micro and macro: L-H transition dynamics and threshold physics Citation Details In-Document Search Title: Linking the micro and macro: L-H transition dynamics and ...

  20. Link to the Utilities by Zip Code File | OpenEI Community

    Open Energy Info (EERE)

    Link to the Utilities by Zip Code File Home > Groups > Utility Rate I am trying to access the link to the utility by zip code csv file from the following side bar on the utility...

  1. DOE Wind Energy R&D is Linked to Innovations Within and Outside...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Wind Energy R&D is Linked to Innovations Within and Outside Wind Power Industry, Study Finds DOE Wind Energy R&D is Linked to Innovations Within and Outside Wind Power Industry, ...

  2. Find Us Links | OSTI, US Dept of Energy, Office of Scientific...

    Office of Scientific and Technical Information (OSTI)

    Find Us Links OSTI Facebook OSTI Twitter OSTI Google+ (Link will open in a new window) Subscribe to the Newsletter Issue issue-3-january-february-2013 Go to full ...

  3. Cross-linked comb-shaped anion exchange membranes with high base stability

    SciTech Connect (OSTI)

    Li, NW; Wang, LZ; Hickner, M

    2014-01-01

    A unique one-step cross-linking strategy that connects quaternary ammonium centers using Grubbs II-catalyzed olefin metathesis was developed. The cross-linked anion exchange membranes showed swelling ratios of less than 10% and hydroxide conductivities of 18 to 40 mS cm(- 1). Cross-linking improved the membranes' stability to hydroxide degradation compared to their non-cross-linked analogues.

  4. Topics: Uncovering the physics of magnetic self-organization and links to

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    astrophysics - MST - UW Plasma Physics Uncovering the physics of magnetic self-organization and links to astrophysics UW Madison Madison Symmetric Torus Topics: Uncovering the physics of magnetic self-organization and links to astrophysics MST HomeGraduate Student InformationLinksTourControl and Auxiliary SystemsPhysics TopicsDeviceResearch MissionMST People mst logo CPLA Home Directory Publications Links Internal University of Wisconsin Physics Department Research funding includes support

  5. Coding Links on Websites Outside of the Energy.gov Drupal Environment

    Broader source: Energy.gov [DOE]

    If you're coding links for a website outside of the Energy.gov environment, follow these guidelines. This includes explanations of how to code links, how to add the "external website" pop-up, how to create "back to top" links, and how to code skipped navigation.

  6. Linked supramolecular building blocks for enhanced cluster formation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    McLellan, Ross; Palacios, Maria A.; Beavers, Christine M.; Teat, Simon J.; Piligkos, Stergios; Brechin, Euan K.; Dalgarno, Scott J.

    2015-01-09

    Methylene-bridged calix[4]arenes have emerged as extremely versatile ligand supports in the formation of new polymetallic clusters possessing fascinating magnetic properties. Metal ion binding rules established for this building block allow one to partially rationalise the complex assembly process. The ability to covalently link calix[4]arenes at the methylene bridge provides significantly improved control over the introduction of different metal centres to resulting cluster motifs. Clusters assembled from bis-calix[4]arenes and transition metal ions or 3d-4f combinations display characteristic features of the analogous calix[4]arene supported clusters, thereby demonstrating an enhanced and rational approach towards the targeted synthesis of complex and challenging structures.

  7. Query optimization for graph analytics on linked data using SPARQL

    SciTech Connect (OSTI)

    Hong, Seokyong; Lee, Sangkeun; Lim, Seung -Hwan; Sukumar, Sreenivas R.; Vatsavai, Ranga Raju

    2015-07-01

    Triplestores that support query languages such as SPARQL are emerging as the preferred and scalable solution to represent data and meta-data as massive heterogeneous graphs using Semantic Web standards. With increasing adoption, the desire to conduct graph-theoretic mining and exploratory analysis has also increased. Addressing that desire, this paper presents a solution that is the marriage of Graph Theory and the Semantic Web. We present software that can analyze Linked Data using graph operations such as counting triangles, finding eccentricity, testing connectedness, and computing PageRank directly on triple stores via the SPARQL interface. We describe the process of optimizing performance of the SPARQL-based implementation of such popular graph algorithms by reducing the space-overhead, simplifying iterative complexity and removing redundant computations by understanding query plans. Our optimized approach shows significant performance gains on triplestores hosted on stand-alone workstations as well as hardware-optimized scalable supercomputers such as the Cray XMT.

  8. Linked supramolecular building blocks for enhanced cluster formation

    SciTech Connect (OSTI)

    McLellan, Ross; Palacios, Maria A.; Beavers, Christine M.; Teat, Simon J.; Piligkos, Stergios; Brechin, Euan K.; Dalgarno, Scott J.

    2015-01-09

    Methylene-bridged calix[4]arenes have emerged as extremely versatile ligand supports in the formation of new polymetallic clusters possessing fascinating magnetic properties. Metal ion binding rules established for this building block allow one to partially rationalise the complex assembly process. The ability to covalently link calix[4]arenes at the methylene bridge provides significantly improved control over the introduction of different metal centres to resulting cluster motifs. Clusters assembled from bis-calix[4]arenes and transition metal ions or 3d-4f combinations display characteristic features of the analogous calix[4]arene supported clusters, thereby demonstrating an enhanced and rational approach towards the targeted synthesis of complex and challenging structures.

  9. Linking strain anisotropy and plasticity in copper metallization

    SciTech Connect (OSTI)

    Murray, Conal E. Jordan-Sweet, Jean; Priyadarshini, Deepika; Nguyen, Son

    2015-05-04

    The elastic anisotropy of copper leads to significant variation in the x-ray elastic constants (XEC), which link diffraction-based strain measurements to stress. An accurate depiction of the mechanical response in copper thin films requires a determination of an appropriate grain interaction model that lies between Voigt and Reuss limits. It is shown that the associated XEC weighting fraction, x*, between these limits provides a metric by which strain anisotropy can be quantified. Experimental values of x*, as determined by a linear regression scheme of diffraction data collected from multiple reflections, reveal the degree of strain anisotropy and its dependence on plastic deformation induced during in-situ and ex-situ thermal treatments.

  10. X-linked inheritance in neuronal migration disorders (NMD)

    SciTech Connect (OSTI)

    Andermann, E.; Dubeau, F.; Tampieri, D.

    1994-09-01

    With the advent of MRI imaging, an increasing number of NMD have been identified in patients with epilepsy. Although most cases have been sporadic, families with these disorders have now been reported in several types of NMD. Furthermore, subcortical bank heterotopia (SBH) or {open_quotes}double cortex syndrome{close_quotes} and periventricular nodular heterotopia (PNH) have a marked female predominance. Two females with SBH, mild mental retardation and seizures had sons with lissencephaly, severe retardation and seizures, and daughters with SBH. X-linked lissencephaly has been observed in several other families, and one girl with lissencephaly was found to have a de novo X-autosomal translocation with a breakpoint in chromosome Xq22. We have studied three families with two or more generations affected by PNH in females, a high frequency of spontaneous abortions and abnormal sex ratios in sibships. The clinical manifestations include seizures and normal intelligence. Three other families with PNH in females have been reported in the literature. Bilateral perisylvian polymicrogyria has been reported in monozygotic twins and in siblings, and we have studied a brother and sister with an affected maternal uncle. These findings suggest sex-linked dominant inheritance with male lethality or severe expression in males. The three disorders described above may represent different mutations of a single gene or mutations in two or more genes on the X-chromosome. At least one gene is probably located in chromosome band Xq22. Genetic linkage studies in families with NMD as well as a search for candidate genes such as adhesion molecules known to map on the X-chromosome should lead to the identification of the gene(s) responsible for these disorders.

  11. Energy harvesting from vibration with cross-linked polypropylene piezoelectrets

    SciTech Connect (OSTI)

    Zhang, Xiaoqing; Wu, Liming; Sessler, Gerhard M.

    2015-07-15

    Piezoelectret films are prepared by modification of the microstructure of polypropylene foam sheets cross-linked by electronic irradiation (IXPP), followed by proper corona charging. Young’s modulus, relative permittivity, and electromechanical coupling coefficient of the fabricated films, determined by dielectric resonance spectra, are about 0.7 MPa, 1.6, and 0.08, respectively. Dynamic piezoelectric d{sub 33} coefficients up to 650 pC/N at 200 Hz are achieved. The figure of merit (FOM, d{sub 33} ⋅ g{sub 33}) for a more typical d{sub 33} value of 400 pC/N is about 11.2 GPa{sup −1}. Vibration-based energy harvesting with one-layer and two-layer stacks of these films is investigated at various frequencies and load resistances. At an optimum load resistance of 9 MΩ and a resonance frequency of 800 Hz, a maximum output power of 120 μW, referred to the acceleration g due to gravity, is obtained for an energy harvester consisting of a one-layer IXPP film with an area of 3.14 cm{sup 2} and a seismic mass of 33.7 g. The output power can be further improved by using two-layer stacks of IXPP films in electric series. IXPP energy harvesters could be used to energize low-power electronic devices, such as wireless sensors and LED lights.

  12. Heterogeneity analysis in 40 X-linked retinitis pigmentosa families

    SciTech Connect (OSTI)

    Teague, P.W.; Aldred, M.A.; Dempster, M.; Harrison, C.; Carothers, A.D.; Hardwick, L.J.; Evans, H.J.; Wright, A.F.; Strain, L.; Brock, D.J.H. )

    1994-07-01

    Analysis of genetic heterogeneity in 40 kindreds with X-linked retinitis pigmentosa (XLRP), with 20 polymorphic markers, showed that significant heterogeneity is present (P=.001) and that 56% of kindreds are of RP3 type and that 26% are of RP2 type. The location of the RP3 locus was found to be 0.4 cM distal to OTC in the Xp21.1 region, and that of the RP2 locus was 6.5 cM proximal to DXS7 in Xp11.2-p11.3. Bayesian probabilities of linkage to RP2, RP3, or to neither locus were calculated. This showed that 20 of 40 kindreds could be assigned to one or the other locus, with a probability >.70 (14 kindreds with RP3 and 6 kindreds with RP2 disease). A further three kindreds were found to be unlinked to either locus, with a probability >.8. The remaining 17 kindreds could not be classified unambiguously. This highlights the difficulty of classifying families in the presence of genetic heterogeneity, where two loci are separated by an estimated 16 cM. 34 refs., 1 fig., 4 tabs.

  13. Cross-linking of polytetrafluoroethylene during room-temperature irradiation

    SciTech Connect (OSTI)

    Pugmire, David L; Wetteland, Chris J; Duncan, Wanda S; Lakis, Rollin E; Schwartz, Daniel S

    2008-01-01

    Exposure of polytetrafluoroethylene (PTFE) to {alpha}-radiation was investigated to detennine the physical and chemical effects, as well as to compare and contrast the damage mechanisms with other radiation types ({beta}, {gamma}, or thermal neutron). A number of techniques were used to investigate the chemical and physical changes in PTFE after exposure to {alpha}-radiation. These techniques include: Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and fluorescence spectroscopy. Similar to other radiation types at low doses, the primary damage mechanism for the exposure of PTFE to {alpha}-radiation appears to be chain scission. Increased doses result in a change-over of the damage mechanism to cross-linking. This result is not observed for any radiation type other than {alpha} when irradiation is performed at room temperature. Finally, at high doses, PTFE undergoes mass-loss (via smallfluorocarbon species evolution) and defluorination. The amount and type of damage versus sample depth was also investigated. Other types of radiation yield damage at depths on the order of mm to cm into PTFE due to low linear energy transfer (LET) and the correspondingly large penetration depths. By contrast, the {alpha}-radiation employed in this study was shown to only induce damage to a depth of approximately 26 {mu}m, except at very high doses.

  14. Microsoft Word - GNEP Website Glossary 2006-02-03_no_links.doc | Department

    Office of Environmental Management (EM)

    of Energy GNEP Website Glossary 2006-02-03_no_links.doc Microsoft Word - GNEP Website Glossary 2006-02-03_no_links.doc Microsoft Word - GNEP Website Glossary 2006-02-03_no_links.doc (29.63 KB) More Documents & Publications GNEP Glossary Generation-IV Roadmap Report of the Fuel Cycle Crosscut Group DOE-HDBK-1113-2008

  15. L-Aspartate Links for Stable Sodium Metal-Organic Frameworks...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    L-Aspartate Links for Stable Sodium Metal-Organic Frameworks Previous Next List Siman, Peter; ... linker with flexible carboxylate groups to enhance framework stability. ...

  16. DOE Wind Energy R&D is Linked to Innovations Within and Outside Wind Power

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Industry, Study Finds | Department of Energy Wind Energy R&D is Linked to Innovations Within and Outside Wind Power Industry, Study Finds DOE Wind Energy R&D is Linked to Innovations Within and Outside Wind Power Industry, Study Finds DOE Wind Energy R&D is Linked to Innovations Within and Outside Wind Power Industry, Study Finds, an EERE Retrospective Study Brief, September 2009. Advances in today's commercial wind energy generation are extensively linked to the Department of

  17. High Conductivity Single-ion Cross-linked Polymers for Lithium...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Conductivity Single-ion Cross-linked Polymers for Lithium Batteries and Fuel Cells ... for use as membranes in lithium batteries, fuel cells, and electrochromic windows. ...

  18. Non-Cross-Linked Gel Polymer Electrolytes for Lithium Ion Batteries...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Non-Cross-Linked Gel Polymer Electrolytes for Lithium Ion Batteries Lawrence Berkeley ... have invented nanostructured gel polymer electrolytes for lithium ion batteries. ...

  19. Final Report: DOE Project: DE-SC-0005399 Linking the uncertainty...

    Office of Scientific and Technical Information (OSTI)

    Linking the uncertainty of low frequency variability in tropical forcing in regional climate change Citation Details In-Document Search Title: Final Report: DOE Project:...

  20. Duke University Writes About Physics Link Between JLab Father-Daughter

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (Duke Physics News) | Jefferson Lab Duke University Writes About Physics Link Between JLab Father-Daughter (Duke Physics News) External Link: http://news.phy.duke.edu/2012/08/duke-physics-is-a-family-tradition-for-chip-and... By jlab_admin on Mon, 2012-08-0

  1. The cce/8.3.0 C++ compiler may run into a linking error on Edison

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The cce8.3.0 C++ compiler may run into a linking error on Edison The cce8.3.0 C++ compiler may run into a linking error on Edison July 1, 2014 You may run into the following...

  2. Missing links in the root-soil organic matter continuum

    SciTech Connect (OSTI)

    O'Brien, Sarah L.; Iversen, Colleen M

    2009-01-01

    The soil environment remains one of the most complex and poorly understood research frontiers in ecology. Soil organic matter (SOM), which spans a continuum from fresh detritus to highly processed, mineral-associated organic matter, is the foundation of sustainable terrestrial ecosystems. Heterogeneous SOM pools are fueled by inputs from living and dead plants, driven by the activity of micro- and mesofauna, and are shaped by a multitude of abiotic factors. The specialization required to measure unseen processes that occur on a wide range of spatial and temporal scales has led to the partitioning of soil ecology research across several disciplines. In the organized oral session 'Missing links in the root-soil organic matter continuum' at the annual Ecological Society of America meeting in Albuquerque, NM, USA, we joined the call for greater communication and collaboration among ecologists who work at the root-soil interface (e.g. Coleman, 2008). Our goal was to bridge the gap between scientific disciplines and to synthesize disconnected pieces of knowledge from root-centric and soil-centric studies into an integrated understanding of belowground ecosystem processes. We focused this report around three compelling themes that arose from the session: (1) the influence of the rhizosphere on SOM cycling, (2) the role of soil heterotrophs in driving the transformation of root detritus to SOM, and (3) the controlling influence of the soil environment on SOM dynamics. We conclude with a discussion of new approaches for gathering data to bridge gaps in the root-SOM continuum and to inform the next generation of ecosystem models. Although leaf litter has often been considered to be the main source of organic inputs to soil, Ann Russell synthesized a convincing body of work demonstrating that roots, rather than surface residues, control the accumulation of SOM in a variety of ecosystems. Living roots, which are chemically diverse and highly dynamic, also influence a wide

  3. Applications of Laminar Weak-Link Mechanisms for Ultraprecision Synchrotron Radiation Instruments

    SciTech Connect (OSTI)

    Shu, D.; Toellner, T. S.; Alp, E. E.; Maser, J.; Ilavsky, J.; Shastri, S. D.; Lee, P. L.; Narayanan, S.; Long, G. G. [Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439 (United States)

    2007-01-19

    Unlike traditional kinematic flexure mechanisms, laminar overconstrained weak-link mechanisms provide much higher structure stiffness and stability. Using a laminar structure configured and manufactured by chemical etching and lithography techniques, we are able to design and build linear and rotary weak-link mechanisms with ultrahigh positioning sensitivity and stability for synchrotron radiation applications. Applications of laminar rotary weak-link mechanism include: high-energy-resolution monochromators for inelastic x-ray scattering and x-ray analyzers for ultra-small-angle scattering and powder-diffraction experiments. Applications of laminar linear weak-link mechanism include high-stiffness piezo-driven stages with subnanometer resolution for an x-ray microscope. In this paper, we summarize the recent designs and applications of the laminar weak-link mechanisms at the Advanced Photon Source.

  4. EIA - Natural Gas Pipeline System - Links to U.S. Natural Gas Pipeline

    U.S. Energy Information Administration (EIA) Indexed Site

    Systems Links About U.S. Natural Gas Pipelines - Transporting Natural Gas based on data through 2007/2008 with selected updates Links to U.S. Natural Gas Pipeline Information - The links below will either direct the user to a narrative describing the system, a pipeline system map, a FERC prescribed "Informational Postings" page, or a FERC Tariff Sheet. Pipeline Name Type of System Regions of Operations Acadian Gas Pipeline System Intrastate Southwest Algonquin Gas Transmission Co

  5. Embedded calibration system for the DIII-D Langmuir probe analog fiber optic links

    SciTech Connect (OSTI)

    Watkins, J. G. [Sandia National Laboratories, Livermore, California (United States); Rajpal, R.; Mandaliya, H. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat (India); Watkins, M.; Boivin, R. L. [General Atomics, San Diego, California (United States)

    2012-10-15

    This paper describes a generally applicable technique for simultaneously measuring offset and gain of 64 analog fiber optic data links used for the DIII-D fixed Langmuir probes by embedding a reference voltage waveform in the optical transmitted signal before every tokamak shot. The calibrated data channels allow calibration of the power supply control fiber optic links as well. The array of fiber optic links and the embedded calibration system described here makes possible the use of superior modern data acquisition electronics in the control room.

  6. Appendix A: GPRA08 benefits estimates: NEMS and MARKAL Model Baseline Cases

    SciTech Connect (OSTI)

    None, None

    2009-01-18

    Document summarizes the results of the benefits analysis of EERE’s programs, as described in the FY 2008 Budget Request. EERE estimates benefits for its overall portfolio and nine Research, Development, Demonstration, and Deployment (RD3) programs.

  7. OPM'S ONLINE COURSE: "LINKING AND DEVELOPING MEASURABLE SES RESULTS-FOCUSED PERFORMANCE REQUIREMENTS

    Broader source: Energy.gov [DOE]

    OPM is pleased to share an online course developed for senior executives entitled, “Linking and Developing Measurable SES Results-Focused Performance Requirements http://www.hru.gov/course_catalog...

  8. OPM's Online Course: "Linking and Developing Measurable SES Results-Focused Performance Requirements

    Broader source: Energy.gov [DOE]

    OPM is pleased to share an online course developed for senior executives entitled, “Linking and Developing Measurable SES Results-Focused Performance Requirements http://www.hru.gov/course_catalog...

  9. Linked Open Data Workshop in Washington, D.C. | OpenEI Community

    Open Energy Info (EERE)

    Linked Open Data Workshop in Washington, D.C. Home > Features > Groups Content Group Activity By term Q & A Feeds Content type Blog entry Discussion Document Event Poll...

  10. Linked Open Data Workshop in Washington, D.C. - Q & A | OpenEI...

    Open Energy Info (EERE)

    - Q & A Home > Linked Open Data Workshop in Washington, D.C. Content Group Activity By term Q & A Feeds No questions have been added to this group yet....

  11. Linked Open Data Workshop in Washington, D.C. | OpenEI Community

    Open Energy Info (EERE)

    Groups > Groups > Linked Open Data Workshop in Washington, D.C. Content Group Activity By term Q & A Feeds There are no feeds from external sites for this group. Groups Menu You...

  12. Cross-linking proteins with bimetallic tetracarboxylate compounds of transition metals

    DOE Patents [OSTI]

    Kostic, Nenad M.; Chen, Jian

    1991-03-05

    Stable cross-linked complexes of transition-metal tetracarboxylates and proteins are formed. The preferred transition-metal is rhodium. The protein may be collagen or an enzyme such as a proteolytic enzyme.

  13. Cross-Linked Conjugated Polymer Fibrils: Robust Nanowires from Functional Polythiophene Diblock Copolymers

    SciTech Connect (OSTI)

    Hammer, Brenton A. G.; Bokel, Felicia A.; Hayward, Ryan C.; Emrick, Todd

    2011-09-27

    A series of poly(3-hexyl thiophene) (P3HT)-based diblock copolymers were prepared and examined in solution for their assembly into fibrils, and post-assembly cross-linking into robust nanowire structures. P3HT-b-poly(3-methanol thiophene) (P3MT), and P3HT-b-poly(3-aminopropyloxymethyl thiophene) (P3AmT) diblock copolymers were synthesized using Grignard metathesis (GRIM) polymerization. Fibrils formed from solution assembly of these copolymers are thus decorated with hydroxyl and amine functionality, and cross-linking is achieved by reaction of diisocyanates with the hydroxyl and amine groups. A variety of cross-linked structures, characterized by transmission electron microscopy (TEM), were produced by this method, including dense fibrillar sheets, fibril bundles, or predominately individual fibrils, depending on the chosen reaction conditions. In solution, the cross-linked fibrils maintained their characteristic vibronic structure in solvents that would normally disrupt (dissolve) the structures.

  14. The Office of Health, Safety and Security link to the VPPPA

    Broader source: Energy.gov [DOE]

    Need to know which sites are current DOE-VPP or OSHA VPP Sites? The link, below, will take you to a Voluntary Protection Programs Participant's Association web page where you may search for current VPP sites by state.

  15. Effect of cross-link density on carbon dioxide separation in polydimethylsiloxane-norbornene membranes

    SciTech Connect (OSTI)

    Hong, Tao; Niu, Zhenbin; Hu, Xunxiang; Gmernicki, Kevin; Cheng, Shiwang; Fan, Fei; Johnson, J. Casey; Hong, Eunice; Mahurin, Shannon; Jiang, De -en; Long, Brian; Mays, Jimmy; Sokolov, Alexei; Saito, Tomonori

    2015-01-01

    The development of high performance materials for CO2 separation and capture will significantly contribute to a solution for climate change. In this work, (bicycloheptenyl) ethyl terminated polydimethylsiloxane (PDMSPNB) membranes with varied cross-link densities were synthesized via ring-opening metathesis polymerization. The developed polymer membranes show higher permeability and better selectivity than those of conventional cross-linked PDMS membrane. The achieved performance (CO2 permeability ~ 6800 Barrer and CO2/N2 selectivity ~ 14) is very promising for practical applications. The key to achieving this high performance is the use of an in-situ cross-linking method of the difunctional PDMS macromonomers, which provides lightly cross-linked membranes. By combining positron annihilation lifetime spectroscopy, broadband dielectric spectroscopy and gas solubility measurements, we have elucidated the key parameters necessary for achieving their excellent performance.

  16. Effect of cross-link density on carbon dioxide separation in polydimtheylsiloxane-norbornene membranes

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hong, Tao; Niu, Zhenbin; Hu, Xunxiang; Gmernicki, Kevin R.; Cheng, Shiwang; Fan, Fei; Johnson, Joseph C.; Hong, Eunice K.; Mahurin, Shannon Mark; Jiang, De-en; et al

    2015-01-01

    Here, the development of high-performance materials for carbon dioxide separation and capture will significantly contribute to a solution for climate change. Herein, (bicycloheptenyl)ethylterminated polydimethylsiloxane (PDMSPNB) membranes with varied cross-link densities were synthesized via ring-opening metathesis polymerization. The developed polymer membranes show higher permeability and better selectivity than those of conventional cross-linked PDMS membrane. The achieved performance (CO2 permeability ≈ 6800 Barrer; CO2/N2 selectivity ≈ 14) is very promising for practical applications. The key to achieving this high performance is the use of an in situ cross-linking method for difunctional PDMS macromonomers, which provides lightly cross-linked membranes. By combining positron annihilationmore » lifetime spectroscopy, broadband dielectric spectroscopy, and gas solubility measurements, key parameters necessary for achieving excellent performance have been elucidated.« less

  17. Effect of cross-link density on carbon dioxide separation in polydimethylsiloxane-norbornene membranes

    SciTech Connect (OSTI)

    Hong, Tao; Niu, Zhenbin; Hu, Xunxiang; Gmernicki, Kevin; Cheng, Shiwang; Fan, Fei; Johnson, J. Casey; Hong, Eunice; Mahurin, Shannon; Jiang, De -en; Long, Brian; Mays, Jimmy; Sokolov, Alexei; Saito, Tomonori

    2015-11-02

    The development of high performance materials for CO2 separation and capture will significantly contribute to a solution for climate change. In this work, (bicycloheptenyl) ethyl terminated polydimethylsiloxane (PDMSPNB) membranes with varied cross-link densities were synthesized via ring-opening metathesis polymerization. The developed polymer membranes show higher permeability and better selectivity than those of conventional cross-linked PDMS membrane. The achieved performance (CO2 permeability ~ 6800 Barrer and CO2/N2 selectivity ~ 14) is very promising for practical applications. The key to achieving this high performance is the use of an in-situ cross-linking method of the difunctional PDMS macromonomers, which provides lightly cross-linked membranes. By combining positron annihilation lifetime spectroscopy, broadband dielectric spectroscopy and gas solubility measurements, we have elucidated the key parameters necessary for achieving their excellent performance.

  18. Effect of cross-link density on carbon dioxide separation in polydimethylsiloxane-norbornene membranes

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hong, Tao; Niu, Zhenbin; Hu, Xunxiang; Gmernicki, Kevin; Cheng, Shiwang; Fan, Fei; Johnson, J. Casey; Hong, Eunice; Mahurin, Shannon; Jiang, De -en; et al

    2015-01-01

    The development of high performance materials for CO2 separation and capture will significantly contribute to a solution for climate change. In this work, (bicycloheptenyl) ethyl terminated polydimethylsiloxane (PDMSPNB) membranes with varied cross-link densities were synthesized via ring-opening metathesis polymerization. The developed polymer membranes show higher permeability and better selectivity than those of conventional cross-linked PDMS membrane. The achieved performance (CO2 permeability ~ 6800 Barrer and CO2/N2 selectivity ~ 14) is very promising for practical applications. The key to achieving this high performance is the use of an in-situ cross-linking method of the difunctional PDMS macromonomers, which provides lightly cross-linked membranes.more » By combining positron annihilation lifetime spectroscopy, broadband dielectric spectroscopy and gas solubility measurements, we have elucidated the key parameters necessary for achieving their excellent performance.« less

  19. Cross-linking proteins with bimetallic tetracarboxylate compounds of transition metals

    DOE Patents [OSTI]

    Kostic, N.M.; Chen, J.

    1991-03-05

    Stable cross-linked complexes of transition-metal tetracarboxylates and proteins are formed. The preferred transition-metal is rhodium. The protein may be collagen or an enzyme such as a proteolytic enzyme. No Drawings

  20. International Energy Module

    Gasoline and Diesel Fuel Update (EIA)

    self-contained units which are linked by an integrating mechanism. The NEMS International Energy Module (IEM) computes world oil prices, provides a set of crude oil and refined...

  1. LINKS NYC Showcases Promising Technologies from DOE's Labs to the Private

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Sector and Investor Community | Department of Energy LINKS NYC Showcases Promising Technologies from DOE's Labs to the Private Sector and Investor Community LINKS NYC Showcases Promising Technologies from DOE's Labs to the Private Sector and Investor Community June 29, 2016 - 4:37pm Addthis Blog post by the Clean Energy Investment Center, June 29, 2016. The Department of Energy's (DOE)'s Clean Energy Investment Center (CEIC) held a second successful Laboratory-Investor Knowledge Series

  2. Modification of Lignin by Protein Cross-linking to Facilitate Production of

    Office of Scientific and Technical Information (OSTI)

    Biofuels From Poplar (Technical Report) | SciTech Connect Modification of Lignin by Protein Cross-linking to Facilitate Production of Biofuels From Poplar Citation Details In-Document Search Title: Modification of Lignin by Protein Cross-linking to Facilitate Production of Biofuels From Poplar The limited supply of fossil fuels and the associated environmental issues associated with their utilization has resulted in much effort put forth to promote renewable resources of energy. Switching to

  3. Linking instantaneous rate of injection to X-ray needle lift measurements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for a direct-acting piezoelectric injector | Argonne National Laboratory Linking instantaneous rate of injection to X-ray needle lift measurements for a direct-acting piezoelectric injector Title Linking instantaneous rate of injection to X-ray needle lift measurements for a direct-acting piezoelectric injector Publication Type Journal Article Year of Publication 2016 Authors Viera, JP, Payri, R, Swantek, A, Duke, D, Sovis, N, Kastengren, A, Powell, CF Journal Energy Conversion and

  4. EERE Success Story-Ford-Dow Partnership Is Linked to Carbon Fiber

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Research at ORNL | Department of Energy Ford-Dow Partnership Is Linked to Carbon Fiber Research at ORNL EERE Success Story-Ford-Dow Partnership Is Linked to Carbon Fiber Research at ORNL May 16, 2013 - 12:00am Addthis EERE provided funding to Dow Chemical, Ford Motor Company, and ORNL to demonstrate a novel polymer fiber material and production process technology. These funds support EERE's strategy of investing in emerging technologies that create high-quality, domestic manufacturing jobs

  5. Links - Center for Plasma in the Laboratory and Astrophysics - UW Madison

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Department Links UW Madison Center for Plasma in the Laboratory and Astrophysics Links CPLA Home - Experiments Madison Symmetric Torus Madsion Dynamo Experiment Rotating Wall Machine Plasma-Couette Experiment Madison Plasma Dynamo Experiment - Theory Groups MHD Turbulence Transport in Fusion Devices Plasma Astrophysics RFP Theory - Multi-Institutional Centers Center for Magnetic Self Organization Center for Theory and Computation Center for Momentum Transport and Flow Organization

  6. Related Links

    Office of Energy Efficiency and Renewable Energy (EERE)

    Since there are an abundance of bioenergy-related websites, we have organized them into the following categories to facilitate your search:

  7. Cool Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Los Alamos National Laboratory Homepage A list of Los Alamos ... LANL Community Programs Office STEM education programs What kind of science are we doing at Los Alamos ...

  8. Relevant Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Institiute(AMRI), UNO Area Hotels Chase Suite Hotel Baton Rouge Extended Stay America Holiday Inn South Baton Rouge Marriott Residence Inns Wyndham Garden Gulf Coast...

  9. Related Links

    Broader source: Energy.gov [DOE]

    The Advanced Manufacturing Office (AMO) aligns its activities with recommendations from the President and his advisors, while drawing insights from industrial experts and research institutions. Learn more about national priorities for manufacturing from these influential reports.

  10. Resources & Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Project (PNWSGDP) Bonneville Power Administration (BPA) Wind Power CAISO Smart Grid Roadmap EPRI Cost & Benefit report for Smart Grid CERA: Smart Grid: Closing the Gap Between...

  11. Related Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    laser beams onto a fusion target about the size of a pencil eraser. NIF became operational in March 2009. NIF is the size of a sports stadium-three football fields could fit inside...

  12. MSDS Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MSDS on the internet The Office of Occupational and Environmental Safety maintains a file of Material Safety Data Sheets (MSDS) sheets for LSU. Each laboratory or other location...

  13. Training Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Software Policies User Surveys NERSC Users Group Help Staff Blogs Request Repository Mailing List Need Help? Out-of-hours Status and Password help Call operations: 1-800-66-NERSC, ...

  14. HELPFUL LINKS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science.gov Communications Page Defense Finance and Accounting Agency (DFAS) FBI Headquarters Freedom of Information Act (FOIA) Home Page Nuclear Regulatory Commission (NRC) ...

  15. Protecting a HVDC link against accidental isolation from its receiving AC system

    SciTech Connect (OSTI)

    Whitehouse, R.S. )

    1993-07-01

    When an HVdc scheme is isolated from its receiving ac system, the inverter may continue to operate, generating its own ac bus voltages; this is defined here as islanding. If islanding is allowed to continue unrestricted, then main circuit components may in some conditions be damaged and it is therefore necessary to provide a suitable protection system. This paper outlines the protection scheme developed for the McNeill Back-to-Back HVdc link in Alberta, Canada, to prevent damage due to islanding while still permitting the link to automatically restart on reclosure of the isolating breaker. Oscillograms showing the protection in operation on both the GEC ALSTHOM HVdc simulator and during tests carried out as part of the commissioning of the McNeill HV dc link are included.

  16. Remote facility sharing with ATM networks [PC based ATM Link Delay Simulator (LDS)]. Final report

    SciTech Connect (OSTI)

    Kung, H. T.

    2001-06-01

    The ATM Link Delay Simulator (LDS) adds propagation delay to the ATM link on which it is installed, to allow control of link propagation delay in network protocol experiments simulating an adjustable piece of optical fiber. Our LDS simulates a delay of between 1.5 and 500 milliseconds and is built with commodity PC hardware, only the ATM network interface card is not generally available. Our implementation is special in that it preserves the exact spacing of ATM data cells a feature that requires sustained high performance. Our implementation shows that applications demanding sustained high performance are possible on commodity PC hardware. This illustrates the promise that PC hardware has for adaptability to demanding specialized testing of high speed network.

  17. Tuning of cross-linking and mechanical properties of laser-deposited poly (methyl methacrylate) films

    SciTech Connect (OSTI)

    Sueske, Erik; Scharf, Thorsten; Krebs, Hans-Ulrich; Panchenko, Elena; Junkers, Thomas; Egorov, Mark; Buback, Michael; Kijewski, Harald

    2005-03-15

    The chemical composition, amount of cross-linking and its influence on the mechanical properties of poly(methyl methacrylate) (PMMA) thin films produced by pulsed laser deposition (PLD) at a wavelength of 248 nm under ultrahigh vacuum were investigated by infrared spectroscopy, scanning electron microscopy, size-exclusion chromatography, thermogravimetric analysis, and nanoindentation experiments. The films consist of two components, one fraction with a molecular weight well below that of the target material and a second fraction, which is cross-linked. Compared to bulk material, the Young's modulus of the film is increased. The amount of cross-linking in the film can be tuned by the applied laser fluence leading to changes of the mechanical properties.

  18. Local intelligent electronic device (IED) rendering templates over limited bandwidth communication link to manage remote IED

    DOE Patents [OSTI]

    Bradetich, Ryan; Dearien, Jason A; Grussling, Barry Jakob; Remaley, Gavin

    2013-11-05

    The present disclosure provides systems and methods for remote device management. According to various embodiments, a local intelligent electronic device (IED) may be in communication with a remote IED via a limited bandwidth communication link, such as a serial link. The limited bandwidth communication link may not support traditional remote management interfaces. According to one embodiment, a local IED may present an operator with a management interface for a remote IED by rendering locally stored templates. The local IED may render the locally stored templates using sparse data obtained from the remote IED. According to various embodiments, the management interface may be a web client interface and/or an HTML interface. The bandwidth required to present a remote management interface may be significantly reduced by rendering locally stored templates rather than requesting an entire management interface from the remote IED. According to various embodiments, an IED may comprise an encryption transceiver.

  19. Los Alamos lab director to link science education, national security in

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TEDxABQ talk Lab director to link science education, national security in talk Los Alamos lab director to link science education, national security in TEDxABQ talk McMillan will describe the events that led to his career in science and share suggestions on how non-scientists can inspire young people to STEM careers and scientific literacy. September 5, 2013 Los Alamos National Laboratory Director Charlie McMillan Los Alamos National Laboratory Director Charlie McMillan Contact Fred deSousa

  20. High PID Resistant Cross-Linked Encapsulnt Based on Polyolefin SOLAR ASCE |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy PID Resistant Cross-Linked Encapsulnt Based on Polyolefin SOLAR ASCE High PID Resistant Cross-Linked Encapsulnt Based on Polyolefin SOLAR ASCE Presented at the PV Module Reliability Workshop, February 26 - 27 2013, Golden, Colorado pvmrw13_ps4_mitsui_zenkoh.pdf (690.22 KB) More Documents & Publications Acceleration Factors for Damp-Heat and HAST with High Voltage Stress Agenda for the PV Module Reliability Workshop, February 26 - 27 2013, Golden, Colorado Hail Impact

  1. Photo of the Week: Mapping the Link between Invasive Plants and Wildfire in

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Mojave Desert | Department of Energy Mapping the Link between Invasive Plants and Wildfire in the Mojave Desert Photo of the Week: Mapping the Link between Invasive Plants and Wildfire in the Mojave Desert August 21, 2013 - 4:03pm Addthis Scientists at Pacific Northwest National Laboratory (PNNL) are using predictive tools to understand ecological changes driven by frequent fires due to invasive plant species in California’s Mojave Desert. In collaboration with the U.S. Geological

  2. Compiling with -ipo produces "unresolved" warning messages at link time on

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cray systems Compiling with -ipo produces "unresolved" warning messages at link time on Cray systems Compiling with -ipo produces "unresolved" warning messages at link time on Cray systems November 18, 2013 by Mike Stewart, NERSC USG Status: Reported to the darshan developers. Updated June 12, 2015 by Scott French, NERSC USG Updated March 9, 2016 by Jialin Liu, NERSC DAS This bug affects our Cray systems Edison and Cori, and is still present as of March 2016. When a code

  3. Faculty Links - Links - Cyclotron Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Faculty Websites Dr. Rainer Fries Dr. Carl Gagliardi Dr. Dan Melconian Dr. Saskia Mioduszewski Dr. Ralf Rapp Dr. Robert Tribble Dr. Dave Youngblood

  4. Hybrid Multidimensional Relational and Link Analytical Knowledge Discovery for Law Enforcement

    SciTech Connect (OSTI)

    Joslyn, Cliff A.; Gillen, David S.; Burke, John S.; Critchlow, Terence J.; Damante, Matt; Fernandes, Robert

    2008-08-01

    The challenges facing the Department of Homeland Security (DHS) require not only multi-dimensional, but also multi-scale data analysis. In particular, the ability to seamlessly move from summary information, such as trends, into detailed analysis of individual entities, while critical for law enforcement, typically requires manually transferring information among multiple tools. Such time-consuming and error prone processes significantly hamper the analysts' ability to quickly explore data and identify threats. As part of a DHS Science and Technology effort, we have been developing and deploying for Immigration and Customs Enforcement the CubeLink system integrating information between relational data cubes and link analytical semantic graphs. In this paper we describe CubeLink in terms of the underlying components, their integration, and the formal mapping from multidimensional data analysis into link analysis. In so doing, we provide a formal basis for one particular form of automatic schema-ontology mapping from OLAP data cubes to semantic graphs databases, and point the way towards future ``intelligent'' OLAP data cubes equipped with meta-data about their dimensional typing.

  5. Cross-Linked Nanoporous Materials from Reactive and Multifunctional Block Polymers

    SciTech Connect (OSTI)

    Seo, Myungeun; Amendt, Mark A.; Hillmyer, Marc A.

    2012-10-10

    Polylactide-b-poly(styrene-co-2-hydroxyethylmethacrylate) (PLA-b-P(S-co-HEMA)) and polylactide-b-poly(styrene-co-2-hydroxyethylacrylate) (PLA-b-P(S-co-HEA)) were synthesized by combination of ring-opening polymerization and reversible addition-fragmentation chain transfer polymerization. {sup 1}H nuclear magnetic resonance spectroscopy and size exclusion chromatography data indicated that the polymerizations were controlled and that hydroxyl groups were successfully incorporated into the block polymers. The polymers were reacted with 4,4{prime}-methylenebis(phenyl isocyanate) (MDI) to form the corresponding cross-linked materials. The materials were annealed at 150 C to complete the coupling reaction. Robust nanoporous materials were obtained from the cross-linked polymers by treatment with aqueous base to hydrolyze the PLA phase. Small-angle X-ray scattering study combined with scanning electron microscopy showed that MDI-cross-linked PLA-b-P(S-co-HEMA)/PLA-b-P(S-co-HEA) can adopt lamellar, hexagonally perforated lamellar, and hexagonally packed cylindrical morphologies after annealing. In particular, the HPL morphology was found to evolve from lamellae due to increase in volume fraction of PS phase as MDI reacted with hydroxyl groups. The reaction also kinetically trapped the morphology by cross-linking. Bicontinuous morphologies were also observed when dibutyltin dilaurate was added to accelerate reaction between the polymer and MDI.

  6. Study of fibreoptic communication links with the optical regeneration of signals

    SciTech Connect (OSTI)

    Shtyrina, O V; Fedoruk, Mikhail P; Turitsyn, Sergei K

    2005-02-28

    Wavelength-division-multiplexing fibreoptic communication links with optical 2R regenerators based on a saturable absorber are mathematically simulated. The results of optimisation of specific configurations of symmetric lines are presented, and it is shown that the transmission distance in systems with the periodic optical regeneration of signals considerably exceeds that in systems without optical regenerators. (fibreoptic communication. waveguides)

  7. Temperature dependence of creep compliance of highly cross-linked epoxy: A molecular simulation study

    SciTech Connect (OSTI)

    Khabaz, Fardin Khare, Ketan S. Khare, Rajesh

    2014-05-15

    We have used molecular dynamics (MD) simulations to study the effect of temperature on the creep compliance of neat cross-linked epoxy. Experimental studies of mechanical behavior of cross-linked epoxy in literature commonly report creep compliance values, whereas molecular simulations of these systems have primarily focused on the Youngs modulus. In this work, in order to obtain a more direct comparison between experiments and simulations, atomistically detailed models of the cross-linked epoxy are used to study their creep compliance as a function of temperature using MD simulations. The creep tests are performed by applying a constant tensile stress and monitoring the resulting strain in the system. Our results show that simulated values of creep compliance increase with an increase in both time and temperature. We believe that such calculations of the creep compliance, along with the use of time temperature superposition, hold great promise in connecting the molecular insight obtained from molecular simulation at small length- and time-scales with the experimental behavior of such materials. To the best of our knowledge, this work is the first reported effort that investigates the creep compliance behavior of cross-linked epoxy using MD simulations.

  8. Variable Delay Element For Jitter Control In High Speed Data Links

    DOE Patents [OSTI]

    Livolsi, Robert R.

    2002-06-11

    A circuit and method for decreasing the amount of jitter present at the receiver input of high speed data links which uses a driver circuit for input from a high speed data link which comprises a logic circuit having a first section (1) which provides data latches, a second section (2) which provides a circuit generates a pre-destorted output and for compensating for level dependent jitter having an OR function element and a NOR function element each of which is coupled to two inputs and to a variable delay element as an input which provides a bi-modal delay for pulse width pre-distortion, a third section (3) which provides a muxing circuit, and a forth section (4) for clock distribution in the driver circuit. A fifth section is used for logic testing the driver circuit.

  9. Wire like link for cycle reproducible and cycle accurate hardware accelerator

    DOE Patents [OSTI]

    Asaad, Sameh; Kapur, Mohit; Parker, Benjamin D

    2015-04-07

    First and second field programmable gate arrays are provided which implement first and second blocks of a circuit design to be simulated. The field programmable gate arrays are operated at a first clock frequency and a wire like link is provided to send a plurality of signals between them. The wire like link includes a serializer, on the first field programmable gate array, to serialize the plurality of signals; a deserializer on the second field programmable gate array, to deserialize the plurality of signals; and a connection between the serializer and the deserializer. The serializer and the deserializer are operated at a second clock frequency, greater than the first clock frequency, and the second clock frequency is selected such that latency of transmission and reception of the plurality of signals is less than the period corresponding to the first clock frequency.

  10. A Linked-Cell Domain Decomposition Method for Molecular Dynamics Simulation on a Scalable Multiprocessor

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yang, L. H.; Brooks III, E. D.; Belak, J.

    1992-01-01

    A molecular dynamics algorithm for performing large-scale simulations using the Parallel C Preprocessor (PCP) programming paradigm on the BBN TC2000, a massively parallel computer, is discussed. The algorithm uses a linked-cell data structure to obtain the near neighbors of each atom as time evoles. Each processor is assigned to a geometric domain containing many subcells and the storage for that domain is private to the processor. Within this scheme, the interdomain (i.e., interprocessor) communication is minimized.

  11. OSTIblog Articles in the E-Link Topic | OSTI, US Dept of Energy Office of

    Office of Scientific and Technical Information (OSTI)

    Scientific and Technical Information Link Topic DOE OSTI Implements Re-organization: Sticking to Our Knitting While Meeting New Challenges by Brian Hitson 08 Apr, 2015 in The Department of Energy (DOE) Office of Scientific and Technical Information (OSTI), a unit of the Office of Science, recently completed a restructuring to fulfill agency-wide responsibilities to collect, preserve, and disseminate scientific and technical information (STI) emanating from DOE research and development

  12. Largest Reduction of Solar Energy in 24 Years Recorded at PSEL Linked to El

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Niño Largest Reduction of Solar Energy in 24 Years Recorded at PSEL Linked to El Niño - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery

  13. Characterization of intact N- and O-linked glycopeptides using higher energy collisional dissociation

    SciTech Connect (OSTI)

    Cao, Li; Tolic, Nikola; Qu, Yi; Meng, Da; Zhao, Rui; Zhang, Qibin; Moore, Ronald J.; Zink, Erika M.; Lipton, Mary S.; Pasa-Tolic, Ljiljana; Wu, Si

    2014-01-15

    Simultaneous elucidation of the glycan structure and the glycosylation site are needed to reveal the biological function of protein glycosylation. In this study, we employed a recent type of fragmentation termed higher energy collisional dissociation (HCD) to examine fragmentation patterns of intact glycopeptides generated from a mixture of standard glycosylated proteins. The normalized collisional energy (NCE) value for HCD was varied from 30% to 60% to evaluate the optimal conditions for the fragmentation of peptide backbones and glycoconjugates. Our results indicated that HCD with lower NCE valuespreferentially fragmented the sugar chains attached to the peptides to generate a ladder of neutral loss of monosaccharides, thus enabling the putative glycan structure characterization. Also, detection of the oxonium ions enabled unambiguous differentiation of glycopeptides from non-glycopeptides. On the contrary, HCD with higher NCE values preferentially fragmented the peptide backbone and thus provided information needed for confident peptide identification. We evaluated the HCD approach with alternating NCE parameters for confident characterization of intact N-linked and O-linked glycopeptides in a single liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. In addition, we applied a novel data analysis pipeline, so-called GlycoFinder, to form a basis for automated data analysis. Overall, 38 unique intact glycopeptides corresponding to eight glycosylation sites (including six N-linked and two O-linked sites) were confidently identified from a standard protein mixture. This approach provided concurrent characterization of both, the peptide and the glycan, thus enabling comprehensive structural characterization of glycoproteins in a single LC-MS/MS analysis.

  14. Natural Gas Processing: The Crucial Link Between Natural Gas Production and Its Transportation to Market

    U.S. Energy Information Administration (EIA) Indexed Site

    Processing: The Crucial Link Between Natural Gas Production and Its Transportation to Market Energy Information Administration, Office of Oil and Gas, January 2006 1 The natural gas product fed into the mainline gas transportation system in the United States must meet specific quality measures in order for the pipeline grid to operate properly. Consequently, natural gas produced at the wellhead, which in most cases contains contaminants 1 and natural gas liquids, 2 must be processed, i.e.,

  15. Switchable photoconductivity of quantum dot films using cross-linking ligands with light-sensitive structures.

    SciTech Connect (OSTI)

    Lilly, G. Daniel; Whalley, Adam C.; Grunder, Sergio; Valente, Cory; Frederick, Matthew T.; Stoddart, J. Fraser; Weiss, Emily A.

    2011-01-01

    This paper describes the use of a diarylethylene (DAE) ligand, which adopts structures that are sensitive to the wavelength of light, to cross-link films of CdSe quantum dots (QDs) within electrical junctions with photoswitchable conductivity. These QD-DAE films are deposited on indium-tin-oxide/poly(3,4-ethylenedioxy-thiophene):poly(styrenesulfonate) (ITO/PEDOT:PSS) electrodes and have eutectic Ga-In top-contacts. The photocurrent density of the cross-linked QD films is enhanced by a factor of 6.5 (averaged over all applied voltages) when the DAE ligand is switched from its open, non-conductive form (by illumination with 500650 nm light) to its closed, conductive form (by illumination with 300400 nm light). This enhancement is accomplished by changing the inter-particle electronic coupling, not the inter-particle distance. Identical QD films cross-linked with dibenzenedithiol ligands have a photoconductivity that is insensitive to the wavelength of light.

  16. Improving Power System Modeling. A Tool to Link Capacity Expansion and Production Cost Models

    SciTech Connect (OSTI)

    Diakov, Victor; Cole, Wesley; Sullivan, Patrick; Brinkman, Gregory; Margolis, Robert

    2015-11-01

    Capacity expansion models (CEM) provide a high-level long-term view at the prospects of the evolving power system. In simulating the possibilities of long-term capacity expansion, it is important to maintain the viability of power system operation in the short-term (daily, hourly and sub-hourly) scales. Production-cost models (PCM) simulate routine power system operation on these shorter time scales using detailed load, transmission and generation fleet data by minimizing production costs and following reliability requirements. When based on CEM 'predictions' about generating unit retirements and buildup, PCM provide more detailed simulation for the short-term system operation and, consequently, may confirm the validity of capacity expansion predictions. Further, production cost model simulations of a system that is based on capacity expansion model solution are 'evolutionary' sound: the generator mix is the result of logical sequence of unit retirement and buildup resulting from policy and incentives. The above has motivated us to bridge CEM with PCM by building a capacity expansion - to - production cost model Linking Tool (CEPCoLT). The Linking Tool is built to onset capacity expansion model prescriptions onto production cost model inputs. NREL's ReEDS and Energy Examplar's PLEXOS are the capacity expansion and the production cost models, respectively. Via the Linking Tool, PLEXOS provides details of operation for the regionally-defined ReEDS scenarios.

  17. Zero-length Cross-linking in Solid State as an Approach for Analysis of Protein -Protein Interactions

    SciTech Connect (OSTI)

    Elshafey, Ahmed; Tolic, Nikola; Young, Malin M.; Sale, Kenneth L.; Smith, Richard D.; Kery, Vladimir

    2006-03-01

    Analyzing the architecture of protein complexes is a difficult task. Chemical cross-linking is often used in combination with mass spectrometric analysis to elucidate the interaction interfaces between proteins. We have developed a new approach for the analysis of interacting interfaces in protein complexes based on cross-linking in the solid state. Protein complexes are freeze-dried under vacuum and cross-links are introduced in the solid phase by dehydrating the protein in a non-water solvent, thus, creating peptide bonds between amino and carboxyl groups of the interacting peptides. Cross-linked proteins are digested into peptides with trypsin in both H216O and H218O and then readily distinguished in mass spectra by characteristic 8 atomic mass unit (amu) shifts reflecting incorporation of two 18O atoms into each C-terminus of proteolytic peptides. Computer analysis of mass spectrometry (MS) and MS/MS data is used to identify the cross-linked peptides.We demonstrated our method by cross-linking homooligomeric protein complexes alone or in a mixture of many other proteins. Cross-linking in the solid state was shown to be specific and reproducible. Glutathione-S-transferase (GST) from Schistosoma japonicum was studied in more detail. Twenty-seven unique intra-molecular and two inter-molecular cross-linked peptides were identified using tryptic mapping followed by LTQ-MS analysis. Identified cross-links were predominantly of amide origin, but six esters and thioesters were also found. Identified cross-linked peptides were validated by computational (visualization of cross-links in the three-dimensional [3D] structure of GST) and experimental (MS/MS) analyses. Most of the identified cross-links matched interacting peptides in the native 3D structure of GST indicating that the structure of GST and its oligomeric complex remained primarily intact after freeze drying. The pattern of oligomeric GST obtained in solid state was the same as that obtained in solution by Ru

  18. Acid–base bifunctional shell cross-linked micelle nanoreactor for one-pot tandem reaction

    SciTech Connect (OSTI)

    Lee, Li -Chen; Lu, Jie; Weck, Marcus; Jones, Christopher W.

    2015-12-29

    Shell cross-linked micelles (SCMs) containing acid sites in the shell and base sites in the core are prepared from amphiphilic poly(2-oxazoline) triblock copolymers. The materials are utilized as two-chamber nanoreactors for a prototypical acid-base bifunctional tandem deacetalization-nitroaldol reaction. Furthermore, the acid and base sites are localized in different regions of the micelle, allowing the two steps in the reaction sequence to largely proceed in separate compartments, akin to the compartmentalization that occurs in biological systems.

  19. Enhanced visible and near-infrared capabilities of the JET mirror-linked divertor spectroscopy system

    SciTech Connect (OSTI)

    Lomanowski, B. A. Sharples, R. M.; Meigs, A. G.; Conway, N. J.; Zastrow, K.-D.; Heesterman, P.; Kinna, D. [EURATOM Collaboration: JET-EFDA Team

    2014-11-15

    The mirror-linked divertor spectroscopy diagnostic on JET has been upgraded with a new visible and near-infrared grating and filtered spectroscopy system. New capabilities include extended near-infrared coverage up to 1875 nm, capturing the hydrogen Paschen series, as well as a 2 kHz frame rate filtered imaging camera system for fast measurements of impurity (Be II) and deuterium D?, D?, D? line emission in the outer divertor. The expanded system provides unique capabilities for studying spatially resolved divertor plasma dynamics at near-ELM resolved timescales as well as a test bed for feasibility assessment of near-infrared spectroscopy.

  20. Acidbase bifunctional shell cross-linked micelle nanoreactor for one-pot tandem reaction

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lee, Li -Chen; Lu, Jie; Weck, Marcus; Jones, Christopher W.

    2015-12-29

    Shell cross-linked micelles (SCMs) containing acid sites in the shell and base sites in the core are prepared from amphiphilic poly(2-oxazoline) triblock copolymers. The materials are utilized as two-chamber nanoreactors for a prototypical acid-base bifunctional tandem deacetalization-nitroaldol reaction. Furthermore, the acid and base sites are localized in different regions of the micelle, allowing the two steps in the reaction sequence to largely proceed in separate compartments, akin to the compartmentalization that occurs in biological systems.

  1. Linking environmental justice and sustainable development for the 21st century

    SciTech Connect (OSTI)

    Goldman, B.A.

    1995-12-01

    This presentation proposes proposes that environmental justice and sustainable development represent the most significant challenges facing environmental professionals during the next 20 years. It will explore the linkages and tensions between these two emerging fields of research and application, as well as their implications for the environmental professions. Questions addressed will include: (1) What is the conceptual link between these ideas? (2) If cost-benefit analysis, taking, and unfunded mandates are the Republican Congress`s top environmental priorities, what do these issues mean from the perspectives of environmental justice and sustainability? (3) What do the justice and sustainability perspectives imply for the future direction of environmental research and advocacy?

  2. Vapor Sensing Using Conjugated Molecule-Linked Au Nanoparticles in a Silica Matrix

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dirk, Shawn M.; Howell, Stephen W.; Price, B. Katherine; Fan, Hongyou; Washburn, Cody; Wheeler, David R.; Tour, James M.; Whiting, Joshua; Simonson, R. Joseph

    2009-01-01

    Cross-linkedmore » assemblies of nanoparticles are of great value as chemiresistor-type sensors. Herein, we report a simple method to fabricate a chemiresistor-type sensor that minimizes the swelling transduction mechanism while optimizing the change in dielectric response. Sensors prepared with this methodology showed enhanced chemoselectivity for phosphonates which are useful surrogates for chemical weapons. Chemoselective sensors were fabricated using an aqueous solution of gold nanoparticles that were then cross-linked in the presence of the silica precursor, tetraethyl orthosilicate with the α -, ω -dithiolate (which is derived from the in situ deprotection of 1,4-di(Phenylethynyl- 4 ′ , 4 ″ -diacetylthio)-benzene ( 1 ) with wet triethylamine). The cross-linked nanoparticles and silica matrix were drop coated onto interdigitated electrodes having 8  μ m spacing. Samples were exposed to a series of analytes including dimethyl methylphosphonate (DMMP), octane, and toluene. A limit of detection was obtained for each analyte. Sensors assembled in this fashion were more sensitive to dimethyl methylphosphonate than to octane by a factor of 1000.« less

  3. Adaptation of the control equipment to permit 3-terminal operation of the HVDC link between Sardinia, Corsica and mainland Italy

    SciTech Connect (OSTI)

    Mazzoldi, F.; Taisne, J.P.; Martin, C.J.B.; Rowe, B.A.

    1989-04-01

    After more than 20 years service as a conventional 2-terminal HVdc link, the Sardinia-Mainland Italy hvdc link (200MW, 200kV) is now operating as a three-terminal system. The original control equipment has been modified to allow the introduction of a tapping station on the line for 3-terminal operation. The adaptations to the control equipment, including the means to ensure that the convertors are operated within their capabilities, are explained.

  4. Contribution of N-linked glycans on HSV-2 gB to cell–cell fusion and viral entry

    SciTech Connect (OSTI)

    Luo, Sukun; Hu, Kai; He, Siyi; Wang, Ping; Zhang, Mudan; Huang, Xin; Du, Tao; Zheng, Chunfu; Liu, Yalan; Hu, Qinxue

    2015-09-15

    HSV-2 is the major cause of genital herpes and its infection increases the risk of HIV-1 acquisition and transmission. HSV-2 glycoprotein B together with glycoproteins D, H and L are indispensable for viral entry, of which gB, as a class III fusogen, plays an essential role. HSV-2 gB has seven potential N-linked glycosylation (N-CHO) sites, but their significance has yet to be determined. For the first time, we systematically analyzed the contributions of N-linked glycans on gB to cell–cell fusion and viral entry. Our results demonstrated that, of the seven potential N-CHO sites on gB, mutation at N390, N483 or N668 decreased cell–cell fusion and viral entry, while mutation at N133 mainly affected protein expression and the production of infectious virus particles by blocking the transport of gB from the endoplasmic reticulum to Golgi. Our findings highlight the significance of N-linked glycans on HSV-2 gB expression and function. - Highlights: • N-linked glycan at N133 is important for gB intracellular trafficking and maturation. • N-linked glycans at N390, N483 and N668 on gB are necessary for optimal cell–cell fusion. • N-linked glycans at N390, N483 and N668 on gB are necessary for optimal viral entry.

  5. Thermoreversible Changes in Aligned and Cross-Linked Block Copolymer Melts Studied by Two Color Depolarized Light Scattering

    SciTech Connect (OSTI)

    Wilbur, Jeffrey D.; Gomez, Enrique D.; Ellsworth, Mark W.; Garetz, Bruce A.; Balsara, Nitash P.

    2012-09-04

    A procedure for creating samples that can be repeatedly cycled between weakly aligned and strongly aligned states is described. Poly(styrene-b-isoprene) block copolymer samples were first shear-aligned and then cross-linked using a high energy electron beam. Samples with more than 1.0 cross-links per chain on average showed almost complete recovery of their initial alignment state even after 20 cycles of heating above the order–disorder transition temperature of the un-cross-linked block copolymer. Samples with 1.1 cross-links per chain, which showed over 90% loss of alignment on heating and almost 100% recovery of alignment on cooling, provided the best example of a reversible aligned-to-unaligned transition. Samples with lower cross-linking densities exhibited irreversible loss of alignment upon heating, while those with higher cross-linking densities exhibited less than 90% loss of alignment upon heating. Alignment was quantified by a technique that we call two color depolarized light scattering (TCDLS), an extension of the traditional depolarized light scattering experiment used to determine the state of order in block copolymers. Qualitative confirmation of our interpretation of TCDLS data was obtained by small-angle X-ray scattering and transmission electron microscopy.

  6. Impute DC link (IDCL) cell based power converters and control thereof

    DOE Patents [OSTI]

    Divan, Deepakraj M.; Prasai, Anish; Hernendez, Jorge; Moghe, Rohit; Iyer, Amrit; Kandula, Rajendra Prasad

    2016-04-26

    Power flow controllers based on Imputed DC Link (IDCL) cells are provided. The IDCL cell is a self-contained power electronic building block (PEBB). The IDCL cell may be stacked in series and parallel to achieve power flow control at higher voltage and current levels. Each IDCL cell may comprise a gate drive, a voltage sharing module, and a thermal management component in order to facilitate easy integration of the cell into a variety of applications. By providing direct AC conversion, the IDCL cell based AC/AC converters reduce device count, eliminate the use of electrolytic capacitors that have life and reliability issues, and improve system efficiency compared with similarly rated back-to-back inverter system.

  7. Linking morphology with activity through the lifetime of pretreated PtNi nanostructured thin film catalysts

    SciTech Connect (OSTI)

    Cullen, David A.; Lopez-Haro, Miguel; Bayle-Guillemaud, Pascale; Debe, Mark; Steinbach, Andrew J.; Guetaz, L.

    2015-04-10

    In this study, the nanoscale morphology of highly active Pt3Ni7 nanostructured thin film fuel cell catalysts is linked with catalyst surface area and activity following catalyst pretreatments, conditioning and potential cycling. The significant role of fuel cell conditioning on the structure and composition of these extended surface catalysts is demonstrated by high resolution imaging, elemental mapping and tomography. The dissolution of Ni during fuel cell conditioning leads to highly complex, porous structures which were visualized in 3D by electron tomography. Quantification of the rendered surfaces following catalyst pretreatment, conditioning, and cycling shows the important role pore structure plays in surface area, activity, and durability.

  8. Linking morphology with activity through the lifetime of pretreated PtNi nanostructured thin film catalysts

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cullen, David A.; Lopez-Haro, Miguel; Bayle-Guillemaud, Pascale; Debe, Mark; Steinbach, Andrew J.; Guetaz, L.

    2015-04-10

    In this study, the nanoscale morphology of highly active Pt3Ni7 nanostructured thin film fuel cell catalysts is linked with catalyst surface area and activity following catalyst pretreatments, conditioning and potential cycling. The significant role of fuel cell conditioning on the structure and composition of these extended surface catalysts is demonstrated by high resolution imaging, elemental mapping and tomography. The dissolution of Ni during fuel cell conditioning leads to highly complex, porous structures which were visualized in 3D by electron tomography. Quantification of the rendered surfaces following catalyst pretreatment, conditioning, and cycling shows the important role pore structure plays in surfacemore » area, activity, and durability.« less

  9. Synthesis and characterization of tunable coumarin- linked glasses as new class of organic/inorganic phosphors

    SciTech Connect (OSTI)

    Luridiana, Alberto; Pretta, Gianluca; Secci, Francesco; Frongia, Angelo; Chiriu, Daniele; Carbonaro, Carlo Maria; Corpino, Riccardo; Ricci, Pier Carlo

    2014-10-21

    It is well known that stilbene with a trans conformation is highly fluorescent. From the viewpoint of molecular structure, coumarins bear a carbon-carbon double bond which is fixed as trans conformation as in trans-stilbene through a lactone structure. This can help to avoid the trans-cis transformation of the double bond under ultraviolet (UV) irradiation as observed in stilbene compounds and results in strong fluorescence and high fluorescence quantum yield and photostability in most of coumarin derivatives. Herein we report some preliminary results about the synthesis and spectroscopic characterization of tunable coumarins and the development of a new linkage protocol for the obtainment of monolayer coumarin-covalently linked glasses. The resulting organic/inorganic coumarin/silica based Self-Assembled Monolayer (SMA) film is proposed as new phosphors for the substituting of critical raw materials, like rare earths, in photonics applications.

  10. Linking home energy rating systems with energy efficiency financing: Progress on national and state programs

    SciTech Connect (OSTI)

    Farhar, B.C.; Collins, N.E.; Walsh, R.W.

    1996-10-01

    In 1991 and early 1992, the U.S. Department of Energy (DOE), in cooperation with the U.S. Department of Housing and Urban Development (HUD), established a National Collaborative on Home Energy Rating Systems (HERS) and Energy Efficient Mortgages (EEMs). The Collaborative's purpose was to involve stakeholders at a national policy level to develop a plan leading the nation toward a voluntary system linking HERS with EEMs. The National Renewable Energy Laboratory (NREL) coordinated the National Collaborative's meetings for DOE. Composed of representatives from 25 stakeholder organizations, the Collaborative, after some 14 meetings, reached consensus on two documents, both published by NREL in mg 1992: A National Program for Energy-Efficient Mortgages and Home Energy Rating Systems: A Blueprint for Action and Going National with HERS and EEMs: Issues and Impacts, The Collected Papers of the National Collaborative.

  11. Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Miquel, Sylvie; Leclerc, Marion; Martin, Rebeca; Chain, Florian; Lenoir, Marion; Raguideau, Sébastien; Hudault, Sylvie; Bridonneau, Chantal; Northen, Trent; Bowen, Benjamin; et al

    2015-04-21

    Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified on the basis of human clinical data. The mechanisms underlying its beneficial effects are still unknown. Gnotobiotic mice harboring F. prausnitzii (A2-165) and Escherichia coli (K-12 JM105) were subjected to 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute colitis. The inflammatory colitis scores and a gas chromatography-time of flight (GC/TOF) mass spectrometry-based metabolomic profile were monitored in blood, ileum, cecum, colon, and feces in gnotobiotic mice. The potential anti-inflammatory metabolites were tested in vitro. We obtained stable E. coli and F. prausnitzii-diassociated mice in which E. coli primed the gastrointestinal tract (GIT), allowing a durable andmore » stable establishment of F. prausnitzii. The disease activity index, histological scores, myeloperoxidase (MPO) activity, and serum cytokine levels were significantly lower in the presence of F. prausnitzii after TNBS challenge. The protective effect of F. prausnitzii against colitis was correlated to its implantation level and was linked to overrepresented metabolites along the GIT and in serum. Among 983 metabolites in GIT samples and serum, 279 were assigned to known chemical reactions. Some of them, belonging to the ammonia (α-ketoglutarate), osmoprotective (raffinose), and phenolic (including anti-inflammatory shikimic and salicylic acids) pathways, were associated with a protective effect of F. prausnitzii, and the functional link was established in vitro for salicylic acid. We show for the first time that F. prausnitzii is a highly active commensal bacterium involved in reduction of colitis through in vivo modulation of metabolites along the GIT and in the peripheral blood.« less

  12. Appendix A: GPRA07 benefits estimates: NEMS-GPRA07 and MARKAL-GPRA07 baseline cases

    SciTech Connect (OSTI)

    None, None

    2009-01-18

    This document summarizes the results of the benefits analysis of EERE’s programs, as described in the FY 2007 Budget Request.

  13. F{sub o}F{sub 1}-ATPase activity regulated by external links on {beta} subunits

    SciTech Connect (OSTI)

    Cheng, Jie; Zhang, Xiao-ai; Graduate School of the Chinese Academy of Sciences, Beijing 100049 ; Shu, Yao-Gen; Yue, Jia-Chang

    2010-01-01

    F{sub o}F{sub 1}-ATPase activity is regulated by external links on {beta} subunits with different molecular weight. It is inhibited when anti-{beta} subunit antibody, streptavidin and H9 antibody link on the {beta} subunits successively, but is activated when virus was binded. Western blotting indicated that the employed anti-{beta} antibody target was on the non-catalytic site of the {beta} subunit. Furthermore, an ESR study of spin-labeled ATP (SL-ATP) showed that the affinity of ATP to the holoenzyme increases with increasing external links on the {beta} subunits. This simple regulation method may have great potential in the design of rapid, free labeled, sensitive and selective biosensors.

  14. Cross-Linking and Mass Spectrometry Methodologies to Facilitate Structural Biology: Finding a Path through the Maze

    SciTech Connect (OSTI)

    Merkley, Eric D.; Cort, John R.; Adkins, Joshua N.

    2013-09-01

    Multiprotein complexes, rather than individual proteins, make up a large part of the biological macromolecular machinery of a cell. Understanding the structure and organization of these complexes is critical to understanding cellular function. Chemical cross-linking coupled with mass spectrometry is emerging as a complementary technique to traditional structural biology methods and can provide low-resolution structural information for a multitude of purposes, such as distance constraints in computational modeling of protein complexes. In this review, we discuss the experimental considerations for successful application of chemical cross-linking-mass spectrometry in biological studies and highlight three examples of such studies from the recent literature. These examples (as well as many others) illustrate the utility of a chemical cross-linking-mass spectrometry approach in facilitating structural analysis of large and challenging complexes.

  15. THE FUELING DIAGRAM: LINKING GALAXY MOLECULAR-TO-ATOMIC GAS RATIOS TO INTERACTIONS AND ACCRETION

    SciTech Connect (OSTI)

    Stark, David V.; Kannappan, Sheila J.; Eckert, Kathleen D.; Wei, Lisa H.; Baker, Andrew J.; Leroy, Adam K.; Vogel, Stuart N.

    2013-05-20

    To assess how external factors such as local interactions and fresh gas accretion influence the global interstellar medium of galaxies, we analyze the relationship between recent enhancements of central star formation and total molecular-to-atomic (H{sub 2}/H I) gas ratios, using a broad sample of field galaxies spanning early-to-late type morphologies, stellar masses of 10{sup 7.2}-10{sup 11.2} M{sub Sun }, and diverse stages of evolution. We find that galaxies occupy several loci in a ''fueling diagram'' that plots H{sub 2}/H I ratio versus mass-corrected blue-centeredness, a metric tracing the degree to which galaxies have bluer centers than the average galaxy at their stellar mass. Spiral galaxies of all stellar masses show a positive correlation between H{sub 2}/H I ratio and mass-corrected blue-centeredness. When combined with previous results linking mass-corrected blue-centeredness to external perturbations, this correlation suggests a systematic link between local galaxy interactions and molecular gas inflow/replenishment. Intriguingly, E/S0 galaxies show a more complex picture: some follow the same correlation, some are quenched, and a distinct population of blue-sequence E/S0 galaxies (with masses below key scales associated with transitions in gas richness) defines a separate loop in the fueling diagram. This population appears to be composed of low-mass merger remnants currently in late- or post-starburst states, in which the burst first consumes the H{sub 2} while the galaxy center keeps getting bluer, then exhausts the H{sub 2}, at which point the burst population reddens as it ages. Multiple lines of evidence suggest connected evolutionary sequences in the fueling diagram. In particular, tracking total gas-to-stellar mass ratios within the fueling diagram provides evidence of fresh gas accretion onto low-mass E/S0s emerging from their central starburst episodes. Drawing on a comprehensive literature search, we suggest that virtually all galaxies

  16. Arrested rearrangement of TCR V[beta] genes in thymocytes from children with x-linked severe combined immunodeficiency disease

    SciTech Connect (OSTI)

    Sleasman, J.W.; Harville, T.O.; White, G.B.; Barrett, D.J. ); George, J.F. ); Goodenow, M.M. Univ. of Alabama, Birmingham, AL )

    1994-07-01

    Human X-linked severe combined immunodeficiency disease (SCID) is an immunodeficiency disorder in which T cell development is arrested in the thymic cortex. B lymphocytes in children with X-linked SCID seem to differentiate normally. X-linked SCID is associated with a mutation in the gene that encodes the IL-2R [gamma]-chain. Because TCR-[beta] gene recombination is a pivotal initial event in T lymphocyte onteogeny within the thymus, the authors hypothesized that a failure to express normal IL-2R[gamma] could lead to impaired TCR-[beta] gene recombination in early thymic development. PCR was used to determine the status of TCR-[beta] gene-segment rearrangements in thymic DNA that had been obtained from children with X-linked SCID. The initial step in TCR-[beta] gene rearrangement, that of D[beta] to J[beta] recombination, was readily detected in all thymus samples from children with X-linked SCID; in contrast, V[beta] to DJ[beta] gene rearrangements were undetectable in the same samples. Both D[beta] to J[beta] and V[beta] to DJ[beta] TCR genes were rearranged in the thymic tissues obtained from immunologically normal children. The authors conclude that TCR[beta]-chain gene rearrangement is arrested in children with X-linked SCID. The results suggest a causative relationship between the failure of TCR [beta]-chain gene arrangements to proceed beyond DJ[beta] rearrangements and the production of a nonfunctional IL-2R [gamma]-chain. 45 refs., 3 figs.

  17. Link between hopping models and percolation scaling laws for charge transport in mixtures of small molecules

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ha, Dong -Gwang; Kim, Jang -Joo; Baldo, Marc A.

    2016-04-29

    Mixed host compositions that combine charge transport materials with luminescent dyes offer superior control over exciton formation and charge transport in organic light emitting devices (OLEDs). Two approaches are typically used to optimize the fraction of charge transport materials in a mixed host composition: either an empirical percolative model, or a hopping transport model. We show that these two commonly-employed models are linked by an analytic expression which relates the localization length to the percolation threshold and critical exponent. The relation is confirmed both numerically and experimentally through measurements of the relative conductivity of Tris(4-carbazoyl-9-ylphenyl) amine (TCTA) :1,3-bis(3,5-dipyrid-3-yl-phenyl) benzene (BmPyPb)more » mixtures with different concentrations, where the TCTA plays a role as hole conductor and the BmPyPb as hole insulator. Furthermore, the analytic relation may allow the rational design of mixed layers of small molecules for high-performance OLEDs.« less

  18. Investigating methods of supporting dynamically linked executables on high performance computing platforms.

    SciTech Connect (OSTI)

    Kelly, Suzanne Marie; Laros, James H., III; Pedretti, Kevin Thomas Tauke; Levenhagen, Michael J.

    2009-09-01

    Shared libraries have become ubiquitous and are used to achieve great resource efficiencies on many platforms. The same properties that enable efficiencies on time-shared computers and convenience on small clusters prove to be great obstacles to scalability on large clusters and High Performance Computing platforms. In addition, Light Weight operating systems such as Catamount have historically not supported the use of shared libraries specifically because they hinder scalability. In this report we will outline the methods of supporting shared libraries on High Performance Computing platforms using Light Weight kernels that we investigated. The considerations necessary to evaluate utility in this area are many and sometimes conflicting. While our initial path forward has been determined based on this evaluation we consider this effort ongoing and remain prepared to re-evaluate any technology that might provide a scalable solution. This report is an evaluation of a range of possible methods of supporting dynamically linked executables on capability class1 High Performance Computing platforms. Efforts are ongoing and extensive testing at scale is necessary to evaluate performance. While performance is a critical driving factor, supporting whatever method is used in a production environment is an equally important and challenging task.

  19. A lock-free priority queue design based on multi-dimensional linked lists

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dechev, Damian; Zhang, Deli

    2015-04-03

    The throughput of concurrent priority queues is pivotal to multiprocessor applications such as discrete event simulation, best-first search and task scheduling. Existing lock-free priority queues are mostly based on skiplists, which probabilistically create shortcuts in an ordered list for fast insertion of elements. The use of skiplists eliminates the need of global rebalancing in balanced search trees and ensures logarithmic sequential search time on average, but the worst-case performance is linear with respect to the input size. In this paper, we propose a quiescently consistent lock-free priority queue based on a multi-dimensional list that guarantees worst-case search time of O(logN)more » for key universe of size N. The novel multi-dimensional list (MDList) is composed of nodes that contain multiple links to child nodes arranged by their dimensionality. The insertion operation works by first injectively mapping the scalar key to a high-dimensional vector, then uniquely locating the target position by using the vector as coordinates. Nodes in MDList are ordered by their coordinate prefixes and the ordering property of the data structure is readily maintained during insertion without rebalancing nor randomization. Furthermore, in our experimental evaluation using a micro-benchmark, our priority queue achieves an average of 50% speedup over the state of the art approaches under high concurrency.« less

  20. A lock-free priority queue design based on multi-dimensional linked lists

    SciTech Connect (OSTI)

    Dechev, Damian; Zhang, Deli

    2015-04-03

    The throughput of concurrent priority queues is pivotal to multiprocessor applications such as discrete event simulation, best-first search and task scheduling. Existing lock-free priority queues are mostly based on skiplists, which probabilistically create shortcuts in an ordered list for fast insertion of elements. The use of skiplists eliminates the need of global rebalancing in balanced search trees and ensures logarithmic sequential search time on average, but the worst-case performance is linear with respect to the input size. In this paper, we propose a quiescently consistent lock-free priority queue based on a multi-dimensional list that guarantees worst-case search time of O(logN) for key universe of size N. The novel multi-dimensional list (MDList) is composed of nodes that contain multiple links to child nodes arranged by their dimensionality. The insertion operation works by first injectively mapping the scalar key to a high-dimensional vector, then uniquely locating the target position by using the vector as coordinates. Nodes in MDList are ordered by their coordinate prefixes and the ordering property of the data structure is readily maintained during insertion without rebalancing nor randomization. Furthermore, in our experimental evaluation using a micro-benchmark, our priority queue achieves an average of 50% speedup over the state of the art approaches under high concurrency.

  1. Linking atomistic and mesoscale simulations of nanocrystalline materials : quantitative validation for the case of grain growth.

    SciTech Connect (OSTI)

    Moldovan, D.; Wolf, D.; Phillpot, S. R.; Materials Science Division; Louisiana State Univ.

    2003-11-01

    Using grain growth in nanocrystalline palladium as a simple case study, we demonstrate how a novel mesoscale approach for simulating microstructural evolution in polycrystalline materials can be validated directly against atomic-level simulations of the same system. We first describe molecular dynamics simulations of grain growth in a columnar model microstructure. The atomic-level insights into the grain-growth mechanism gained from these simulations, particularly in the role of grain rotations, are captured theoretically for incorporation into the mesoscale approach, in which the objects evolving in space and time are the grain boundaries and grain junctions rather than the atoms. With all the input parameters to the mesoscale being physically well defined and obtained directly from the atomic-level simulations, the mesoscale simulations are fully prescribed. We find that the morphology of the mesoscale system evolves in an almost identical manner with that of the molecular dynamics simulation, demonstrating that the length- and time-scale linking has been performed correctly. When applied to systems containing large numbers of grains, the now validated mesoscale simulation approach allows the growth topology and long-time growth kinetics to be determined. As an outlook, we describe how the effects of applied stress can be incorporated.

  2. Melamine/formaldehyde cross-linking of polymers for profile control

    SciTech Connect (OSTI)

    Mitchell, T.O.

    1988-11-29

    This patent describes a process for closing pores in a more permeable zone of a hydrocarbonaceous fluid bearing formation to obtain improved sweep efficiency prior to a waterflood oil recovery operation wherein the process comprises injecting into the formation of a gelable composition comprising: (a) water; (b) 0.2 to 5.0 wt. percent of a cross-linkable polymer having at least one functional group selected from a member of the group consisting of an amine, an amide, a hydroxyl, or a thiol group; and (c) 0.1 to 5.0 wt. percent of a methylol containing aminoplast resin which cross links with the polymer, thereby forming a gel of a size and strength sufficient to close pores in one or more permeable zones of the formation, the resin having amine and aldehyde in a critical mole ratio of from about 1:6 to about 1:30 respectively, which ratios are sufficient to form substantially improved stable gels for utilization in a subterranean formation during the recovery of hydrocarbonaceous fluids.

  3. Localizing multiple X chromosome-linked retinitis pigmentosa loci using multilocus homogeneity tests

    SciTech Connect (OSTI)

    Ott, J.; Terwilliger, J.D. ); Bhattacharya, S. ); Chen, J.D.; Denton, J.; Donald, J. ); Dubay, C.; Litt, M.; Weleber, R.G. ); Farrar, G.J.; Humphries, P. ); Fishman, G.A.; Wong, F. ); Frey, D.; Maechler, M. )

    1990-01-01

    Multilocus linkage analysis of 62 family pedigrees with X chromosome-linked retinitis pigmentosa (XLRP) was undertaken to determine the presence of possible multiple disease loci and to reliability estimate their map location. Multilocus homogeneity tests furnish convincing evidence for the presence of two XLRP loci, the likelihood ratio being 6.4 {times} 10{sup 9}:1 in a favor of two versus a single XLRP locus and gave accurate estimates for their map location. In 60-75% of the families, location of an XLRP gene was estimated at 1 centimorgan distal to OTC, and in 25-40% of the families, an XLRP locus was located halfway between DXS14 (p58-1) and DXZ1 (Xcen), with an estimated recombination fraction of 25% between the two XLRP loci. There is also good evidence for third XLRP locus, midway between DXS28 (C7) and DXS164 (pERT87), supported by a likelihood ratio of 293:1 for three versus two XLRP loci.

  4. Towards isolation of the gene for X-linked retinitis pigmentosa (RP3)

    SciTech Connect (OSTI)

    Dry, K.L.; Aldred, M.A.; Hardwick, L.J.

    1994-09-01

    Until recently the region of interest containing the gene for X-linked retinitis pigmentosa (RP3) was thought to lie between CYBB (Xp21.1) and the proximal end of the deletion in patient BB (JBBprox). This region was thought to span 100-150 kb. Here we present new mapping data to show that the distance between the 5{prime} (most proximal) end of CYBB and JBBprox is only 50 kb. Recently Roux et al. (1994) have described the isolation of a gene within this region but this showed no disease-associated changes. Further evidence from mapping the deletion in patient NF (who suffered from McLead`s syndrome and CGD but not RP) and from linkage analysis of our RP3 families with a new dinucleotide repeat suggests that the gene must extend proximally from JBBprox. In order to extend the region of search we have constructed a YAC contig spanning 800 kb to OTC. We are continuing our search for the RP3 gene using a variety of strategies including exon trapping and cDNA enrichment as well as direct screening of cDNA libraries with subclones from this region.

  5. Final Progress Report for Linking Ion Solvation and Lithium Battery Electrolyte Properties

    SciTech Connect (OSTI)

    Henderson, Wesley

    2014-08-29

    The research objective of this proposal was to provide a detailed analysis of how solvent and anion structure govern the solvation state of Li+ cations in solvent-LiX mixtures and how this, in turn, dictates the electrolyte physicochemical and electrochemical properties which govern (in part) battery performance. Lithium battery electrolytes remain a poorly understood and hardly studied topic relative to the research devoted to battery electrodes. This is due to the fact that it is the electrodes which determine the energy (capacity) of the battery. The electrolyte, however, plays a crucial role in the practical energy density, power, low and/or high temperature performance, lifetime, safety, etc. which is achievable. The development within this project of a "looking glass" into the molecular interactions (i.e., solution structure) in bulk electrolytes through a synergistic experimental approach involving three research thrusts complements work by other researchers to optimize multi-solvent electrolytes and efforts to understand/control the electrode-electrolyte interfaces, thereby enabling the rational design of electrolytes for a wide variety of battery chemistries and applications (electrolytes-on-demand). The three research thrusts pursued include: (1) conduction of an in-depth analysis of the thermal phase behavior of diverse solvent-LiX mixtures, (2) exploration of the ionic association/solvate formation behavior of select LiX salts with a wide variety of solvents, and (3) linking structure to properties-determination of electrolyte physicochemical and electrochemical properties for comparison with the ionic association and phase behavior.

  6. Application of Radial Basis Functional Link Networks to Exploration for Proterozoic Mineral Deposits in Central Iran

    SciTech Connect (OSTI)

    Behnia, Pouran [Geological Survey of Iran, Geomatics Department (Iran, Islamic Republic of)], E-mail: pouranb@yahoo.com

    2007-06-15

    The metallogeny of Central Iran is characterized mainly by the presence of several iron, apatite, and uranium deposits of Proterozoic age. Radial Basis Function Link Networks (RBFLN) were used as a data-driven method for GIS-based predictive mapping of Proterozoic mineralization in this area. To generate the input data for RBFLN, the evidential maps comprising stratigraphic, structural, geophysical, and geochemical data were used. Fifty-eight deposits and 58 'nondeposits' were used to train the network. The operations for the application of neural networks employed in this study involve both multiclass and binary representation of evidential maps. Running RBFLN on different input data showed that an increase in the number of evidential maps and classes leads to a larger classification sum of squared error (SSE). As a whole, an increase in the number of iterations resulted in the improvement of training SSE. The results of applying RBFLN showed that a successful classification depends on the existence of spatially well distributed deposits and nondeposits throughout the study area.

  7. THE NONLINEAR AND NONLOCAL LINK BETWEEN MACROSCOPIC ALFVNIC AND MICROSCOPIC ELECTROSTATIC SCALES IN THE SOLAR WIND

    SciTech Connect (OSTI)

    Valentini, F.; Vecchio, A.; Donato, S.; Carbone, V.; Veltri, P.; Briand, C.; Bougeret, J.

    2014-06-10

    The local heating of the solar-wind gas during its expansion represents one of the most intriguing problems in space plasma physics and is at present the subject of a relevant scientific effort. The possible mechanisms that could account for local heat production in the interplanetary medium are most likely related to the turbulent character of the solar-wind plasma. Nowadays, many observational and numerical analyses are devoted to the identification of fluctuation channels along which energy is carried from large to short wavelengths during the development of the turbulent cascade; these fluctuation channels establish the link between macroscopic and microscopic scales. In this Letter, by means of a quantitative comparison between in situ measurements in the solar wind from the STEREO spacecraft and numerical results from kinetic simulations, we identify an electrostatic channel of fluctuations that develops along the turbulent cascade in a direction parallel to the ambient magnetic field. This channel appears to be efficient in transferring the energy from large Alfvnic to short electrostatic acoustic-like scales up to a range of wavelengths where it can finally be turned into heat, even when the electron to proton temperature ratio is of the order of unity.

  8. Linking legacies: Connecting the Cold War nuclear weapons production processes to their environmental consequences

    SciTech Connect (OSTI)

    1997-01-01

    In the aftermath of the Cold War, the US has begun addressing the environmental consequences of five decades of nuclear weapons production. In support of this effort, the National Defense Authorization Act for Fiscal Year 1995 directed the Department of Energy (DOE) to describe the waste streams generated during each step in the production of nuclear weapons. Accordingly, this report responds to this mandate, and it is the Department`s first comprehensive analysis of the sources of waste and contamination generated by the production of nuclear weapons. The report also contains information on the missions and functions of nuclear weapons facilities, on the inventories of waste and materials remaining at these facilities, as well as on the extent and characteristics of contamination in and around these facilities. This analysis unites specific environmental impacts of nuclear weapons production with particular production processes. The Department used historical records to connect nuclear weapons production processes with emerging data on waste and contamination. In this way, two of the Department`s legacies--nuclear weapons manufacturing and environmental management--have become systematically linked. The goal of this report is to provide Congress, DOE program managers, non-governmental analysts, and the public with an explicit picture of the environmental results of each step in the nuclear weapons production and disposition cycle.

  9. Linking the spin evolution of massive black holes to galaxy kinematics

    SciTech Connect (OSTI)

    Sesana, A.; Barausse, E.; Dotti, M.; Rossi, E. M. E-mail: barausse@iap.fr E-mail: emr@strw.leidenuniv.nl

    2014-10-20

    We present the results of a semianalytical model that evolves the masses and spins of massive black holes together with the properties of their host galaxies across the cosmic history. As a consistency check, our model broadly reproduces a number of observations, e.g., the cosmic star formation history; the black hole mass, luminosity, and galaxy mass functions at low redshift; the black hole-bulge mass relation; and the morphological distribution at low redshift. For the first time in a semianalytical investigation, we relax the simplifying assumptions of perfect coherency or perfect isotropy of the gas fueling the black holes. The dynamics of gas is instead linked to the morphological properties of the host galaxies, resulting in different spin distributions for black holes hosted in different galaxy types. We compare our results with the observed sample of spin measurements obtained through broad K? iron line fitting. The observational data disfavor both accretion along a fixed direction and isotropic fueling. Conversely, when the properties of the accretion flow are anchored to the kinematics of the host galaxy, we obtain a good match between theoretical expectations and observations. A mixture of coherent accretion and phases of activity in which the gas dynamics is similar to that of the stars in bulges (i.e., with a significant velocity dispersion superimposed to a net rotation) best describes the data, adding further evidence in support of the coevolution of massive black holes and their hosts.

  10. MARKAL-MACRO: A linked model for energy-economy analysis

    SciTech Connect (OSTI)

    Manne, A.S.; Wene, C.O.

    1992-02-01

    MARKAL-MACRO is an experiment in model linkage for energy and economy analysis. This new tool is intended as an improvement over existing methods for energy strategy assessment. It is designed specifically for estimating the costs and analyzing the technologies proposed for reducing environmental risks such as global climate change or regional air pollution. The greenhouse gas debate illustrates the usefulness of linked energy-economy models. A central issue is the coupling between economic growth, the level of energy demands, and the development of an energy system to supply these demands. The debate is often connected with alternative modeling approaches. The competing philosophies may be labeled ``top-down macroeconomic`` and ``bottom-up engineering`` perspectives. MARKAL is a systems engineering (physical process) analysis built on the concept of a Reference Energy System (RES). MARKAL is solved by means of dynamic linear programming. In most applications, the end use demands are fixed, and an economically efficient solution is obtained by minimizing the present value of energy system`s costs throughout the planning horizon. MACRO is a macroeconomic model with an aggregated view of long-term economic growth. The basis input factors of production are capital, labor and individual forms of energy. MACRO is solved by nonlinear optimization.

  11. MARKAL-MACRO: A linked model for energy-economy analysis

    SciTech Connect (OSTI)

    Manne, A.S. ); Wene, C.O. Chalmers Univ. of Tech., Goeteborg )

    1992-02-01

    MARKAL-MACRO is an experiment in model linkage for energy and economy analysis. This new tool is intended as an improvement over existing methods for energy strategy assessment. It is designed specifically for estimating the costs and analyzing the technologies proposed for reducing environmental risks such as global climate change or regional air pollution. The greenhouse gas debate illustrates the usefulness of linked energy-economy models. A central issue is the coupling between economic growth, the level of energy demands, and the development of an energy system to supply these demands. The debate is often connected with alternative modeling approaches. The competing philosophies may be labeled top-down macroeconomic'' and bottom-up engineering'' perspectives. MARKAL is a systems engineering (physical process) analysis built on the concept of a Reference Energy System (RES). MARKAL is solved by means of dynamic linear programming. In most applications, the end use demands are fixed, and an economically efficient solution is obtained by minimizing the present value of energy system's costs throughout the planning horizon. MACRO is a macroeconomic model with an aggregated view of long-term economic growth. The basis input factors of production are capital, labor and individual forms of energy. MACRO is solved by nonlinear optimization.

  12. Mapping N-linked Glycosylation Sites in the Secretome and Whole Cells of Aspergillus niger Using Hydrazide Chemistry and Mass Spectrometry

    SciTech Connect (OSTI)

    Wang, Lu; Aryal, Uma K.; Dai, Ziyu; Mason, Alisa C.; Monroe, Matthew E.; Tian, Zhixin; Zhou, Jianying; Su, Dian; Weitz, Karl K.; Liu, Tao; Camp, David G.; Smith, Richard D.; Baker, Scott E.; Qian, Weijun

    2012-01-01

    Protein glycosylation is known to play an essential role in both cellular functions and the secretory pathways; however, little information is available on the dynamics of glycosylated N-linked glycosites of fungi. Herein we present the first extensive mapping of glycosylated N-linked glycosites in industrial strain Aspergillus niger by applying an optimized solid phase enrichment of glycopeptide protocol using hydrazide modified magnetic beads. The enrichment protocol was initially optimized using mouse plasma and A. niger secretome samples, which was then applied to profile N-linked glycosites from both the secretome and whole cell lysates of A. niger. A total of 847 unique N-linked glycosites and 330 N-linked glycoproteins were confidently identified by LC-MS/MS. Based on gene ontology analysis, the identified N-linked glycoproteins in the whole cell lysate were primarily localized in the plasma membrane, endoplasmic reticulum, golgi apparatus, lysosome, and storage vacuoles. The identified N-linked glycoproteins are involved in a wide range of biological processes including gene regulation and signal transduction, protein folding and assembly, protein modification and carbohydrate metabolism. The extensive coverage of glycosylated N-linked glycosites along with identification of partial N-linked glycosylation in those enzymes involving in different biochemical pathways provide useful information for functional studies of N-linked glycosylation and their biotechnological applications in A. niger.

  13. Query and Visualization of extremely large network datasets over the web using Quadtree based KML Regional Network Links

    SciTech Connect (OSTI)

    Dadi, Upendra; Liu, Cheng; Vatsavai, Raju

    2009-01-01

    Geographic data sets are often very large in size. Interactive visualization of such data at all scales is not easy because of the limited resolution of the monitors and inability of visualization applications to handle the volume of data. This is especially true for large vector datasets. The end user s experience is frequently unsatisfactory when exploring such data over the web using a naive application. Network bandwidth is another contributing factor to the low performance. In this paper, a Quadtree based technique to visualize extremely large spatial network datasets over the web is described. It involves using custom developed algorithms leveraging a PostGIS database as the data source and Google Earth as the visualization client. This methodology supports both point and range queries along with non-spatial queries. This methodology is demonstrated using a network dataset consisting of several million links. The methodology is based on using some of the powerful features of KML (Keyhole Markup Language). Keyhole Markup Language (KML) is an Open Geospatial Consortium (OGC) standard for displaying geospatial data on Earth browsers. One of the features of KML is the notion of Network Links. Using network links, a wide range of geospatial data sources such as geodatabases, static files and geospatial data services can be simultaneously accessed and visualized seamlessly. Using the network links combined with Level of Detail principle, view based rendering and intelligent server and client-side caching, scalability in visualizing extremely large spatial datasets can be achieved.

  14. Interstaple Dithiol Cross-Linking in Au(25)(SR)(18) Nanomolecules: A Combined Mass Spectrometric and Computational Study

    SciTech Connect (OSTI)

    Jiang, Deen; Dass, Amala; Tschumper, Gregory; Mattern, Daniell; Van Dornshuld, Eric; Kota, Rajesh; Jupally, Vijay

    2011-01-01

    A systematic study of cross-linking chemistry of the Au{sub 25}(SR){sub 18} nanomolecule by dithiols of varying chain length, HS-(CH2)n-SH where n = 2, 3, 4, 5, and 6, is presented here. Monothiolated Au{sub 25} has six [RSAuSRAuSR] staple motifs on its surface, and MALDI mass spectrometry data of the ligand exchanged clusters show that propane (C3) and butane (C4) dithiols have ideal chain lengths for interstaple cross-linking and that up to six C3 or C4 dithiols can be facilely exchanged onto the cluster surface. Propanedithiol predominately exchanges with two monothiols at a time, making cross-linking bridges, while butanedithiol can exchange with either one or two monothiols at a time. The extent of cross-linking can be controlled by the Au{sub 25}(SR){sub 18} to dithiol ratio, the reaction time of ligand exchange, or the addition of a hydrophobic tail to the dithiol. MALDI MS suggests that during ethane (C2) dithiol exchange, two ethanedithiols become connected by a disulfide bond; this result is supported by density functional theory (DFT) prediction of the optimal chain length for the intrastaple coupling. Both optical absorption spectroscopy and DFT computations show that the electronic structure of the Au{sub 25} nanomolecule retains its main features after exchange of up to eight monothiol ligands.

  15. Linking the micro and macro: L-H transition dynamics and threshold physics

    SciTech Connect (OSTI)

    Malkov, M. A. Diamond, P. H.; Miki, K.; Rice, J. E.; Tynan, G. R.

    2015-03-15

    The links between the microscopic dynamics and macroscopic threshold physics of the L → H transition are elucidated. Emphasis is placed on understanding the physics of power threshold scalings, and especially on understanding the minimum in the power threshold as a function of density P{sub thr} (n). By extending a numerical 1D model to evolve both electron and ion temperatures, including collisional coupling, we find that the decrease in P{sub thr} (n) along the low-density branch is due to the combination of an increase in collisional electron-to-ion energy transfer and an increase in the heating fraction coupled to the ions. Both processes strengthen the edge diamagnetic electric field needed to lock in the mean electric field shear for the L→H transition. The increase in P{sub thr} (n) along the high-density branch is due to the increase with ion collisionality of damping of turbulence-driven shear flows. Turbulence driven shear flows are needed to trigger the transition by extracting energy from the turbulence. Thus, we identify the critical transition physics components of the separatrix ion heat flux and the zonal flow excitation. The model reveals a power threshold minimum in density scans as a crossover between the threshold decrease supported by an increase in heat fraction received by ions (directly or indirectly, from electrons) and a threshold increase, supported by the rise in shear flow damping. The electron/ion heating mix emerges as important to the transition, in that it, together with electron-ion coupling, regulates the edge diamagnetic electric field shear. The importance of possible collisionless electron-ion heat transfer processes is explained.

  16. Accommodation of GDP-Linked Sugars in the Active Site of GDP-Perosamine Synthase

    SciTech Connect (OSTI)

    Cook, Paul D.; Carney, Amanda E.; Holden, Hazel M.

    2009-01-12

    Perosamine (4-amino-4,6-dideoxy-d-mannose), or its N-acetylated form, is one of several dideoxy sugars found in the O-antigens of such infamous Gram-negative bacteria as Vibrio cholerae O1 and Escherichia coli O157:H7. It is added to the bacterial O-antigen via a nucleotide-linked version, namely GDP-perosamine. Three enzymes are required for the biosynthesis of GDP-perosamine starting from mannose 1-phosphate. The focus of this investigation is GDP-perosamine synthase from Caulobacter crescentus, which catalyzes the final step in GDP-perosamine synthesis, the conversion of GDP-4-keto-6-deoxymannose to GDP-perosamine. The enzyme is PLP-dependent and belongs to the aspartate aminotransferase superfamily. It contains the typically conserved active site lysine residue, which forms a Schiff base with the PLP cofactor. Two crystal structures were determined for this investigation: a site-directed mutant protein (K186A) complexed with GDP-perosamine and the wild-type enzyme complexed with an unnatural ligand, GDP-3-deoxyperosamine. These structures, determined to 1.6 and 1.7 {angstrom} resolution, respectively, revealed the manner in which products, and presumably substrates, are accommodated within the active site pocket of GDP-perosamine synthase. Additional kinetic analyses using both the natural and unnatural substrates revealed that the K{sub m} for the unnatural substrate was unperturbed relative to that of the natural substrate, but the k{sub cat} was lowered by a factor of approximately 200. Taken together, these studies shed light on why GDP-perosamine synthase functions as an aminotransferase whereas another very similar PLP-dependent enzyme, GDP-4-keto-6-deoxy-d-mannose 3-dehydratase or ColD, catalyzes a dehydration reaction using the same substrate.

  17. Statistical recoupling: A new way to break the link between electric-utility sales and revenues

    SciTech Connect (OSTI)

    Hirst, E.

    1993-09-01

    In 1991, US electric utilities spent almost $1.8 billion on demand-side management (DSM) programs. These programs cut peak demands 5% and reduced electricity sales 1% that year. Utility projections suggest that these reductions will increase to 9% and 3%, respectively, by the year 2001. However, utility DSM efforts vary enormously across the country, concentrated in a few states along the east and west coasts and the upper midwest. To some extent, this concentration is a function of regulatory reforms that remove disincentives to utility shareholders for investments in DSM programs. A key component of these reforms is recovery of the net lost revenues caused by utility DSM programs. These lost revenues occur between rate cases when a utility encourages its customers to improve energy efficiency and cut demand. The reduction in sales means that the utility has less revenue to cover its fixed costs. This report describes a new method, statistical recoupling (SR), that addresses this net-lost-revenue problem. Like other decoupling approaches, SR breaks the link between electric-utility revenues and sales. Unlike other approaches, SR minimizes changes from traditional regulation. In particular, the risks of revenue swings associated with year-to-year changes in weather and the economy remain with the utility under SR. Statistical recoupling uses statistical models, based on historical data, that explain retail electricity sales as functions of the number of utility customers, winter and summer weather, the condition of the local economy, electricity price, and perhaps a few other key variables. These models, along with the actual values of the explanatory variables, are then used to estimate ``allowed`` electricity sales and revenues in future years.

  18. Molecular genetics of X-linked retinitis pigmentosa: Progress towards cloning the RP3 gene

    SciTech Connect (OSTI)

    Fujita, R.; Yan, D.; McHenry, C.

    1994-09-01

    Our goal is to identify the X-linked retinitis pigmentosa (XLRP) gene RP3. The location of RP3 is genetically delimited to a region of 1 Mb, distal to DXS140, CYBB and tctex-1-like gene and proximal to the gene OTC. It is currently thought that RP3 is within 40 kb of the proximal deletion breakpoint of a patient BB. However, a more proximal location of the gene, closer to OTC, is not ruled out. We initiated the isolation of the genomic region between DXS140 to OTC in YACs. One of the clones from DXS140 region (55B) is 460 kb and spans about 200 kb at each side of BB patient`s proximal breakpoint. It contains CYBB, tctex-1-like genes and two additional CpG islands. The 55B clone has been covered by cosmid and phage subclones. Another YAC clone from the OTC region (OTCC) spans about 1 Mb and contains at least 5 CpG islands. In situ hybridization performed with OTCC showed its location in Xp21; however, several derivative cosmids map to chromosome 7, indicating that it is a chimeric YAC. No overlap is evident between 55B and OTCC. We have isolated the YAC end-sequences and isolation of clones to close the gap is in progress. Cosmids are being used for screening eye tissue cDNA libraries, mainly from retina. Screening is done by hybridization to replica filters or by cDNA enrichment methods. Several cDNA clones have been isolated and are being characterized. Exon-amplification is also being used with the cosmids and phages. Genetic analysis is being performed to determine RP3 patients from clinically indistinguishable RP2, located in Xp11.23-p11.4, and to reduce the genetic distance of current flanking markers. For this we are analyzing a number of XLRP families with established markers in the region and with new microsatellites.

  19. Chemosensitivity of primary human fibroblasts with defective unhooking of DNA interstrand cross-links

    SciTech Connect (OSTI)

    Clingen, Peter H. . E-mail: p.clingen@ucl.ac.uk; Arlett, Colin F.; Hartley, John A.; Parris, Christopher N.

    2007-02-15

    Xeroderma pigmentosum (XP) is characterised by defects in nucleotide excision repair, ultraviolet (UV) radiation sensitivity and increased skin carcinoma. Compared to other complementation groups, XP-F patients show relatively mild cutaneous symptoms. DNA interstrand cross-linking agents are a highly cytotoxic class of DNA damage induced by common cancer chemotherapeutics such as cisplatin and nitrogen mustards. Although the XPF-ERCC1 structure-specific endonuclease is required for the repair of ICLs cellular sensitivity of primary human XP-F cells has not been established. In clonogenic survival assays, primary fibroblasts from XP-F patients were moderately sensitive to both UVC and HN2 compared to normal cells (2- to 3-fold and 3- to 5-fold, respectively). XP-A fibroblasts were considerably more sensitive to UVC (10- to 12-fold) but not sensitive to HN2. The sensitivity of XP-F fibroblasts to HN2 correlated with the defective incision or 'unhooking' step of ICL repair. Using the comet assay, XP-F cells exhibited only 20% residual unhooking activity over 24 h. Over the same time, normal and XP-A cells unhooked greater than 95% and 62% of ICLs, respectively. After HN2 treatment, ICL-associated DNA double-strand breaks (DSBs) are detected by pulse field gel electrophoresis in dividing cells. Induction and repair of DNA DSBs was normal in XP-F fibroblasts. These findings demonstrate that in primary human fibroblasts, XPF is required for the unhooking of ICLs and not for the induction or repair of ICL-associated DNA DSBs induced by HN2. In terms of cancer chemotherapy, people with mild DNA repair defects affecting ICL repair may be more prevalent in the general population than expected. Since cellular sensitivity of primary human fibroblasts usually reflects clinical sensitivity such patients with cancer would be at risk of increased toxicity.

  20. LINKING Lyα AND LOW-IONIZATION TRANSITIONS AT LOW OPTICAL DEPTH

    SciTech Connect (OSTI)

    Jaskot, A. E.; Oey, M. S.

    2014-08-20

    We suggest that low optical depth in the Lyman continuum (LyC) may relate the Lyα emission, C II and Si II absorption, and C II* and Si II* emission seen in high-redshift galaxies. We base this analysis on Hubble Space Telescope Cosmic Origins Spectrograph spectra of four Green Pea (GP) galaxies, which may be analogs of z > 2 Lyα emitters (LAEs). In the two GPs with the strongest Lyα emission, the Lyα line profiles show reduced signs of resonant scattering. Instead, the Lyα profiles resemble the Hα line profiles of evolved star ejecta, suggesting that the Lyα emission originates from a low column density and similar outflow geometry. The weak C II absorption and presence of non-resonant C II* emission in these GPs support this interpretation and imply a low LyC optical depth along the line of sight. In two additional GPs, weak Lyα emission and strong C II absorption suggest a higher optical depth. These two GPs differ in their Lyα profile shapes and C II* emission strengths, however, indicating different inclinations of the outflows to our line of sight. With these four GPs as examples, we explain the observed trends linking Lyα, C II, and C II* in stacked LAE spectra, in the context of optical depth and geometric effects. Specifically, in some galaxies with strong Lyα emission, a low LyC optical depth may allow Lyα to escape with reduced scattering. Furthermore, C II absorption, C II* emission, and Lyα profile shape can reveal the optical depth, constrain the orientation of neutral outflows in LAEs, and identify candidate LyC emitters.

  1. Linkage analysis and physical mapping near the gene for x-linked agammaglobulinemia at Xq22

    SciTech Connect (OSTI)

    Parolini, O.; Lassiter, G.L.; Henry, M.J.; Conley, M.E. St. Jude Children's Research Hospital, Memphis, TN ); Hejtmancik, J.F. ); Allen, R.C.; Belmont, J.W. ); Barker, D.F. )

    1993-02-01

    The gene for x-linked agammaglobulinemia (XLA) has been mapped to Xq22. No recombinations have been reported between the gene and the prob p212 at DXS178; however, this probe is informative in only 30-40% of women and the reported flanking markers, DXS3 and DXS94, and 10-15 cM apart. To identify additional probes that might be useful in genetic counseling, we examined 11 polymorphisms that have been mapped to the Xq21.3-q22 region in 13 families with XLA. In addition, pulsed-field gel electrophoresis and yeast artificial chromosomes (YACs) were used to further characterize the segman of DNA within which the gene for SLA must lie. The results demonstrated that DXS366 and DXS442, which share a 430-kb pulsed-field fragment, could replace DXS3 as proximal flanking markers. Probes at DXS178 and DXS265 identified the same 145-kb pulsed-field fragment, and both loci were contained within a 200-kb YAC identified with the probe p212. A highly polymorphic CA repeat (DCS178CA) was isolated from one end of this YAC and used in linkage analysis. Probes at DXS101 and DXS328 shared several pulsed-field fragments, the smallest of which was 250 kb. No recombinations were seen between XLA and the DXS178-DXS265-DXS178CA complex, DXS101, DXS328, DXS87, or the gene for proteolipid protein (PLP). Key crossovers, when combined with the linkage data from families with Alport syndrome, suggested the following order of loci: cen-DXS3-DXS366-DXS442-(PLP, DXS101, DXS328, DXS178-DXS265-DXS178CA complex, XL)-(DXS87, DXS94)-DXS327-(DXS350, DXS362)-tel. Our studies also limit the segment of DNA within which the XLA gene must lie to the 3- to 4-cM distance between DCS442 and DXS94 and they identify and orient polymorphisms that can be used in genetic counseling not only for XLA but also for Pelizaeus-Merzbacher disease (PLP deficiency), Alport syndrome (COL4A5 deficiency), and Fabry disease ([alpha]-galactosidase A difficiency). 31 refs., 5 figs., 2 tabs.

  2. GRB 090227B: THE MISSING LINK BETWEEN THE GENUINE SHORT AND LONG GAMMA-RAY BURSTS

    SciTech Connect (OSTI)

    Muccino, M.; Ruffini, R.; Bianco, C. L.; Izzo, L.; Penacchioni, A. V. [Dip. di Fisica and ICRA, Sapienza Universita di Roma, Piazzale Aldo Moro 5, I-00185 Rome (Italy)] [Dip. di Fisica and ICRA, Sapienza Universita di Roma, Piazzale Aldo Moro 5, I-00185 Rome (Italy)

    2013-02-15

    The time-resolved spectral analysis of GRB 090227B, made possible by the Fermi-GBM data, allows us to identify in this source the missing link between the genuine short and long gamma-ray bursts (GRBs). Within the Fireshell model of the GRBs we predict genuine short GRBs: bursts with the same inner engine of the long bursts but endowed with a severely low value of the baryon load, B {approx}< 5 Multiplication-Sign 10{sup -5}. A first energetically predominant emission occurs at the transparency of the e {sup +} e {sup -} plasma, the Proper-GRB (P-GRB), followed by a softer emission, the extended afterglow. The typical separation between the two emissions is expected to be of the order of 10{sup -3}-10{sup -2} s. We identify the P-GRB of GRB 090227B in the first 96 ms of emission, where a thermal component with the temperature kT = (517 {+-} 28) keV and a flux comparable with the non-thermal part of the spectrum is observed. This non-thermal component as well as the subsequent emission, where there is no evidence for a thermal spectrum, is identified with the extended afterglow. We deduce a theoretical cosmological redshift z = 1.61 {+-} 0.14. We then derive the total energy E{sup tot}{sub e{sup +}e{sup -}}= (2.83{+-}0.15) Multiplication-Sign 10{sup 53} erg, the baryon load B = (4.13 {+-} 0.05) Multiplication-Sign 10{sup -5}, the Lorentz {Gamma} factor at transparency {Gamma}{sub tr} = (1.44 {+-} 0.01) Multiplication-Sign 10{sup 4}, and the intrinsic duration {Delta}t' {approx} 0.35 s. We also determine the average density of the circumburst medium (CBM), (n {sub CBM}) = (1.90 {+-} 0.20) Multiplication-Sign 10{sup -5} particles cm{sup -3}. There is no evidence of beaming in the system. In view of the energetics and of the baryon load of the source, as well as of the low interstellar medium and of the intrinsic timescale of the signal, we identify the GRB progenitor as a binary neutron star. From the recent progress in the theory of neutron stars, we obtain masses of

  3. Automated Demand Response: The Missing Link in the Electricity Value Chain

    SciTech Connect (OSTI)

    McKane, Aimee; Rhyne, Ivin; Piette, Mary Ann; Thompson, Lisa; Lekov, Alex

    2008-08-01

    In 2006, the Public Interest Energy Research Program (PIER) Demand Response Research Center (DRRC) at Lawrence Berkeley National Laboratory initiated research into Automated Demand Response (OpenADR) applications in California industry. The goal is to improve electric grid reliability and lower electricity use during periods of peak demand. The purpose of this research is to begin to define the relationship among a portfolio of actions that industrial facilities can undertake relative to their electricity use. This 'electricity value chain' defines energy management and demand response (DR) at six levels of service, distinguished by the magnitude, type, and rapidity of response. One element in the electricity supply chain is OpenADR, an open-standards based communications system to send signals to customers to allow them to manage their electric demand in response to supply conditions, such as prices or reliability, through a set of standard, open communications. Initial DRRC research suggests that industrial facilities that have undertaken energy efficiency measures are probably more, not less, likely to initiate other actions within this value chain such as daily load management and demand response. Moreover, OpenADR appears to afford some facilities the opportunity to develop the supporting control structure and to 'demo' potential reductions in energy use that can later be applied to either more effective load management or a permanent reduction in use via energy efficiency. Under the right conditions, some types of industrial facilities can shift or shed loads, without any, or minimal disruption to operations, to protect their energy supply reliability and to take advantage of financial incentives. In 2007 and 2008, 35 industrial facilities agreed to implement OpenADR, representing a total capacity of nearly 40 MW. This paper describes how integrated or centralized demand management and system-level network controls are linked to OpenADR systems. Case studies

  4. Automated Demand Response: The Missing Link in the Electricity Value Chain

    SciTech Connect (OSTI)

    McKane, Aimee; Rhyne, Ivin; Lekov, Alex; Thompson, Lisa; Piette, MaryAnn

    2009-08-01

    In 2006, the Public Interest Energy Research Program (PIER) Demand Response Research Center (DRRC) at Lawrence Berkeley National Laboratory initiated research into Automated Demand Response (OpenADR) applications in California industry. The goal is to improve electric grid reliability and lower electricity use during periods of peak demand. The purpose of this research is to begin to define the relationship among a portfolio of actions that industrial facilities can undertake relative to their electricity use. This ?electricity value chain? defines energy management and demand response (DR) at six levels of service, distinguished by the magnitude, type, and rapidity of response. One element in the electricity supply chain is OpenADR, an open-standards based communications system to send signals to customers to allow them to manage their electric demand in response to supply conditions, such as prices or reliability, through a set of standard, open communications. Initial DRRC research suggests that industrial facilities that have undertaken energy efficiency measures are probably more, not less, likely to initiate other actions within this value chain such as daily load management and demand response. Moreover, OpenADR appears to afford some facilities the opportunity to develop the supporting control structure and to"demo" potential reductions in energy use that can later be applied to either more effective load management or a permanent reduction in use via energy efficiency. Under the right conditions, some types of industrial facilities can shift or shed loads, without any, or minimal disruption to operations, to protect their energy supply reliability and to take advantage of financial incentives.1 In 2007 and 2008, 35 industrial facilities agreed to implement OpenADR, representing a total capacity of nearly 40 MW. This paper describes how integrated or centralized demand management and system-level network controls are linked to OpenADR systems. Case studies

  5. Synthesis and reactions of Cp-linked phosphine complexes of rhodium

    SciTech Connect (OSTI)

    Lefort, L.; Crane, T.W.; Farwell, M.D.; Baruch, D.M.; Kaeuper, J.A.; Lachicotte, R.J.; Jones, W.D.

    1998-08-31

    The linked Cp ligand [C{sub 5}H{sub 4}SiMe{sub 2}CH{sub 2}PPh{sub 2}]{sup {minus}} has been used to synthesize several rhodium derivatives. Reaction with [RhClL{sub 2}]{sub 2} where L = C{sub 2}H{sub 4}, C{sub 8}H{sub 14}, or CO, gives ({eta}{sup 5}:{eta}{sup 1}-C{sub 5}H{sub 4}SiMe{sub 2}-CH{sub 2}PPh{sub 2})Rh(L) complexes, which have been characterized by single-crystal X-ray diffraction. Reaction of the ethylene complex with CO or PMe{sub 3} gives the carbonyl- and phosphine-substituted derivatives, respectively. Irradiation of the ethylene complex in the presence of hydrogen gives a new binuclear polyhydride, also structurally characterized, in which the chelating ligand spans the two metal centers. Reaction of the ethylene complex with iodine leads to the formation of the diiodide ({eta}{sup 5}:{eta}{sup 1}-C{sub 5}H{sub 4}SiMe{sub 2}CH{sub 2}PPh{sub 2})RhI{sub 2}, which in turn can be converted to the dihydride ({eta}{sup 5}:{eta}{sup 1}-C{sub 5}H{sub 4}SiMe{sub 2}CH{sub 2}PPh{sub 2})RhH{sub 2} by reaction with NaAl(OCH{sub 2}CH{sub 2}OCH{sub 3}){sub 2}H{sub 2}. The reactivity of the dihydride toward C-H bond activation has been investigated. While benzene does not give a stable oxidative addition adduct, pentafluorobenzene yields ({eta}{sup 5}:{eta}{sup 1}-C{sub 5}H{sub 4}SiMe{sub 2}CH{sub 2}PPh{sub 2})Rh(C{sub 6}F{sub 5})H, which was structurally characterized as its chloro derivative. Reaction of the dihydride with C{sub 6}F{sub 6} gives the {eta}{sup 2} complex ({eta}{sup 5}:{eta}{sup 1}-C{sub 5}H{sub 4}SiMe{sub 2}CH{sub 2}PPh{sub 2})Rh({eta}{sup 2}-C{sub 6}F{sub 6}), also structurally characterized.

  6. Multi-omic data integration links Deleted in Breast Cancer 1 (DBC1) Degradation to Chromatin Remodeling in Inflammatory Response

    SciTech Connect (OSTI)

    Nakayasu, Ernesto S.; Brown, Roslyn N.; Ansong, Charles; Sydor, Michael A.; Imtiaz, Sayed; Mihai, Cosmin; Sontag, Ryan L.; Hixson, Kim K.; Monroe, Matthew E.; Sobreira, Tiago; Orr, Galya; Petyuk, Vladislav A.; Yang, Feng; Smith, Richard D.; Adkins, Joshua N.

    2013-08-12

    Ubiquitination is a common protein post-translational modification that regulates many key cellular functions. Here we investigated the dynamics of ubiquitinated proteins after an inflammatory stimulation of RAW264.7 macrophage-like cells with bacterial lipopolysaccharide. We demonstrate that levels of global ubiquitination, and K48 and K63 polyubiquitination change after lipopolysaccharide stimulation. A quantitative proteomic analysis identified 1199 ubiquitinated proteins, 78 of which had significantly changed ubiquitination levels after lipopolysaccharide stimulation. We next identified a subset of proteins that were targeted for degradation after lipopolysaccharide stimulation, by integrating the ubiquitinome data with global proteomics and transcriptomics results. Using cellular assays and western blot analyses we biochemically validated DBC1, a histone deacetylase inhibitor not previously linked to inflammation, as a degradation substrate, which is targeted via an orchestrated mechanism utilizing caspases and the proteasome. The degradation of DBC1 releases histone deacetylase activity, linking lipopolysaccharide activation to chromatin remodeling in caspase- and proteasome-mediated signaling.

  7. Familial site-specific Ovarian cancer is linked to BRCA1 on 17q12-21

    SciTech Connect (OSTI)

    Steichen-Gersdorf, E.; Gallion, H.H.; Ponder, M.A.; Pye, C.; Mazoyer, S.; Smith, S.A.; Ponder, B.A.J.; Ford, D.; Easton, D.F.; Girodet, C.

    1994-11-01

    In a study of nine families with {open_quotes}site-specific{close_quotes} ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age <50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32-1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46-1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive. 17 refs., 3 figs., 1 tab.

  8. Weak links and critical current anisotropy in melt-textured HTSC ceramics studied by magneto-optical express control

    SciTech Connect (OSTI)

    Belyaeva, A.I.; Eremenko, V.V.; Nastenko, V.A.

    1997-06-01

    YBa{sub 2}Cu{sub 3}O{sub 7{minus}x} ceramics were prepared by the modified melt textured process on the polycrystalline substrate of the YBaCuO{sub 5} composition. Magneto-optical technique with the ferrogarnet films as sensor was used for visualization of magnetic flux distribution and their evaluation under remagnetization of specimens. The pictures of weak links visualized by the magneto-optical technique were correlated with the sample macro- and microstructure, studied by X-ray topography electron (SEM) and polarization fight microscopy. The role of different details of the structural peculiarities of the specimens in the weak links formation was analyzed and the problem of critical current anisotropy was reviewed. The weak links behavior under the magnetic field variation was studied in the details. The pinning centers, weak links, its dependence upon the (211) concentration, the particle size as well as its role in J{sub c} value formation were discussed. Experimental values of the critical current density varied from 2 10{sup 4} up to (5{divided_by}8) 10{sup 5} A cm{sup {minus}2} for the regions of specimen with the different structures. The authors report the first real time direct magneto-optic images of the isotropic magnetic flux distribution in the area of the sample which initially was substrate 211. The principal possibility of their modified method for obtaining highly textured isotropic Y-Ba-Cu-O ceramics capable of carrying current density up to 10{sup 6} A cm{sup {minus}2} was discussed.

  9. The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43

    SciTech Connect (OSTI)

    Rivedal, Edgar Leithe, Edward

    2008-11-01

    Benzene is used at large volumes in many different human activities. Hematotoxicity and cancer-causation as a result of benzene exposure was recognized many years ago, but the mechanisms involved remain unclear. Aberrant regulation of gap junction intercellular communication (GJIC) has been linked to both cancer induction and interference with normal hematopoietic development. We have previously suggested that inhibition of GJIC may play a role in benzene toxicity since benzene metabolites were found to block GJIC, the ring-opened trans,trans-muconaldehyde (MUC) being the most potent metabolite. In the present work we have studied the molecular mechanisms underlying the MUC-induced inhibition of gap junctional communication. We show that MUC induces cross-linking of the gap junction protein connexin43 and that this is likely to be responsible for the induced inhibition of GJIC, as well as the loss of connexin43 observed in Western blots. We also show that glutaraldehyde possesses similar effects as MUC, and we compare the effects to that of formaldehyde. The fact that glutaraldehyde and formaldehyde have been associated with induction of leukemia as well as disturbance of hematopoiesis, strengthens the possible link between the effect of MUC on gap junctions, and the toxic effects of benzene.

  10. Science for Energy Technology: Strengthening the Link Between Basic Research and Industry

    SciTech Connect (OSTI)

    2010-04-01

    The nation faces two severe challenges that will determine our prosperity for decades to come: assuring clean, secure, and sustainable energy to power our world, and establishing a new foundation for enduring economic and jobs growth. These challenges are linked: the global demand for clean sustainable energy is an unprecedented economic opportunity for creating jobs and exporting energy technology to the developing and developed world. But achieving the tremendous potential of clean energy technology is not easy. In contrast to traditional fossil fuel-based technologies, clean energy technologies are in their infancy, operating far below their potential, with many scientific and technological challenges to overcome. Industry is ultimately the agent for commercializing clean energy technology and for reestablishing the foundation for our economic and jobs growth. For industry to succeed in these challenges, it must overcome many roadblocks and continuously innovate new generations of renewable, sustainable, and low-carbon energy technologies such as solar energy, carbon sequestration, nuclear energy, electricity delivery and efficiency, solid state lighting, batteries and biofuels. The roadblocks to higher performing clean energy technology are not just challenges of engineering design but are also limited by scientific understanding.Innovation relies on contributions from basic research to bridge major gaps in our understanding of the phenomena that limit efficiency, performance, or lifetime of the materials or chemistries of these sustainable energy technologies. Thus, efforts aimed at understanding the scientific issues behind performance limitations can have a real and immediate impact on cost, reliability, and performance of technology, and ultimately a transformative impact on our economy. With its broad research base and unique scientific user facilities, the DOE Office of Basic Energy Sciences (BES) is ideally positioned to address these needs. BES has laid

  11. Expedited Synthesis of Fluorine-18 Labeled Phenols. A Missing Link in PET Radiochemistry

    SciTech Connect (OSTI)

    Katzenellenbogen, John A.; Zhou, Dong

    2015-03-26

    Fluorine-18 (F-18) is arguably the most valuable radionuclide for positron emission tomographic (PET) imaging. However, while there are many methods for labeling small molecules with F-18 at aliphatic positions and on electron-deficient aromatic rings, there are essentially no reliable and practical methods to label electron-rich aromatic rings such as phenols, with F-18 at high specific activity. This is disappointing because fluorine-labeled phenols are found in many drugs; there are also many interesting plant metabolites and hormones that contain either phenols or other electron-rich aromatic systems such as indoles whose metabolism, transport, and distribution would be interesting to study if they could readily be labeled with F-18. Most approaches to label phenols with F-18 involve the labeling of electron-poor precursor arenes by nucleophilic aromatic substitution, followed by subsequent conversion to phenols by oxidation or other multi-step sequences that are often inefficient and time consuming. Thus, the lack of good methods for labeling phenols and other electron-rich aromatics with F-18 at high specific activity represents a significant methodological gap in F-18 radiochemistry that can be considered a “Missing Link in PET Radiochemistry”. The objective of this research project was to develop and optimize a series of unusual synthetic transformations that will enable phenols (and other electron-rich aromatic systems) to be labeled with F-18 at high specific activity, rapidly, reliably, and conveniently, thereby bridging this gap. Through the studies conducted with support of this project, we have substantially advanced synthetic methodology for the preparation of fluorophenols. Our progress is presented in detail in the sections below, and much has been published or presented publication; other components are being prepared for publication. In essence, we have developed a completely new method to prepare o-fluorophenols from non-aromatic precursors

  12. Bridging the Divide: Linking Genomics to Ecosystem Responses to Climate Change: Final Report

    SciTech Connect (OSTI)

    Smith, Melinda D.

    2014-03-15

    soil moisture) under a more variable precipitation regime, rather than reduced population numbers (A. gerardii tiller densities did not differ between altered and ambient treatments; p = 0.505) or a priori differences in genotype richness (Avolio et al.2013a). This ecological sorting of genotypes, which accounts for 40% of all sampled individuals in the altered plots, is an important legacy of the press chronic climate changes in the RaMPs experiment. Objective 2 In May 2010, we established the Climate Extremes Experiment at the Konza Prairie Biological Station. For the experiment, a gradient of temperatures, ranging from ambient to extreme, were imposed in 2010 and 2011 as a mid-season heat wave under well-watered or severe drought conditions. This study allowed us for the first time to examine species-specific thresholds of responses to climate extremes and assess how these phenotypic responses may impact selection of particular genotypes, with the ultimate goal of linking alterations in individual performance and genetic diversity to ecosystem structure and functioning. We found that tallgrass prairie was resistant to heat waves, but it was not resistant to extreme drought, which reduced aboveground net primary productivity (ANPP) below the lowest level measured in this grassland in almost thirty years (Hoover et al. in press(a)). This extreme reduction in ecosystem function was a consequence of reduced productivity of both C4 grasses and C3 forbs. This reduction in biomass of the C4 grasses (Andropogon gerardii and Sorghastrum nutans) was, in part, due to significant reductions in photosynthesis, leaf water potential and productivity with drought in the dominant grasses species, with S. nutans was more sensitive than A. gerardii to drought (Hoover et al. in press(b)). However, the dominant forb was negatively impacted by the drought more than the dominant grasses, and this led to a reordering of species abundances within the plant community. Although this change in

  13. IL-2R{gamma} gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease

    SciTech Connect (OSTI)

    Henthorn, P.S.; Fimiani, V.M.; Patterson, D.F.

    1994-09-01

    X-linked severe combined immunodeficiency (SCID) is characterized by profound defects in cellular and humoral immunity and, in humans, is associated with mutations in the gene for the {gamma} chain of the IL-2 receptor (IL-2R{gamma}). We have examined this gene in a colony of dogs established from a single X-linked SCID carrier female. Affected dogs have a 4-bp deletion in the first exon of the IL-2R{gamma} gene, which precludes the production of a functional protein, demonstrating that the canine disease is a true homologue of human X-linked SCID. 37 refs., 3 figs.

  14. Reliable, Efficient and Cost-Effective Electric Power Converter for Small Wind Turbines Based on AC-link Technology

    SciTech Connect (OSTI)

    Darren Hammell; Mark Holveck; DOE Project Officer - Keith Bennett

    2006-08-01

    Grid-tied inverter power electronics have been an Achilles heel of the small wind industry, providing opportunity for new technologies to provide lower costs, greater efficiency, and improved reliability. The small wind turbine market is also moving towards the 50-100kW size range. The unique AC-link power conversion technology provides efficiency, reliability, and power quality advantages over existing technologies, and Princeton Power will adapt prototype designs used for industrial asynchronous motor control to a 50kW small wind turbine design.

  15. An Integrated Approach Linking Process to Structural Modeling With Microstructural Characterization for Injections-Molded Long-Fiber Thermoplastics

    SciTech Connect (OSTI)

    Nguyen, Ba Nghiep; Bapanapalli, Satish K.; Smith, Mark T.; Kunc, Vlastimil; Frame, Barbara; Norris, Robert E.; Phelps, Jay; Tucker III, Charles L.; Jin, Xiaoshi; Wang, Jin

    2008-09-01

    The objective of our work is to enable the optimum design of lightweight automotive structural components using injection-molded long fiber thermoplastics (LFTs). To this end, an integrated approach that links process modeling to structural analysis with experimental microstructural characterization and validation is developed. First, process models for LFTs are developed and implemented into processing codes (e.g. ORIENT, Moldflow) to predict the microstructure of the as-formed composite (i.e. fiber length and orientation distributions). In parallel, characterization and testing methods are developed to obtain necessary microstructural data to validate process modeling predictions. Second, the predicted LFT composite microstructure is imported into a structural finite element analysis by ABAQUS to determine the response of the as-formed composite to given boundary conditions. At this stage, constitutive models accounting for the composite microstructure are developed to predict various types of behaviors (i.e. thermoelastic, viscoelastic, elastic-plastic, damage, fatigue, and impact) of LFTs. Experimental methods are also developed to determine material parameters and to validate constitutive models. Such a process-linked-structural modeling approach allows an LFT composite structure to be designed with confidence through numerical simulations. Some recent results of our collaborative research will be illustrated to show the usefulness and applications of this integrated approach.

  16. Performance of MicroLink Cells Developed Under Navy STTR: Cooperative Research and Development Final Report, CRADA Number CRD-11-426

    SciTech Connect (OSTI)

    Emery, K.

    2013-06-01

    Evaluate MicroLink cells as a function of temperature and spectral irradiance following the teams' standard procedures. These measurements will include the standard procedures for evaluating multijunction cells including quantum efficiency measurements and current versus voltage measurements.

  17. Application for Presidential Permit OE Docket No. PP-400 TDI-NE- New England Clean Power Link Project: Motion to Intervene of The Northeast Power Coordinating Council, Inc.

    Broader source: Energy.gov [DOE]

    Northeast Power Coordinating Council, Inc. (NPCC) submits its Motion to Intervene the New England Clean Power Link Project pursuant to Rules 212 and 214 of the Rules of Practice and Procedures of...

  18. X-linked borderline mental retardation with prominent behavioral disturbance: Phenotype, genetic localization, and evidence for disturbed monoamine metabolism

    SciTech Connect (OSTI)

    Brunner, H.G.; Nelen, M.R.; Zandvoort, P. van; Abeling, N.G.G.M.; Gennip, A.H. van; Ropers, H.H.; Oost, B.A. van ); Wolters, E.C.; Kuiper, M.A. )

    1993-06-01

    The authors have identified a large Dutch kindred with a new form of X-linked nondysmorphic mild mental retardation. All affected males in this family show very characteristic abnormal behavior, in particular aggressive and sometimes violent behavior. Other types of impulsive behavior include arson, attempted rape, and exhibitionism. Attempted suicide has been reported in a single case. The locus for this disorder could be assigned to the Xp11-21 interval between DXS7 and DXS77 by linkage analysis using markers spanning the X chromosome. A maximal multipoint lod score of 3.69 was obtained at the monoamine oxidase type A (MAOA) monoamine metabolism. These data are compatible with a primary defect in the structural gene for MAOA and/or monoamine oxidase type B (MAOB). Normal platelet MAOB activity suggests that the unusual behavior pattern in this family may be caused by isolated MAOA deficiency. 34 refs., 4 figs., 4 tabs.

  19. Kinetics of sorption of Cu(II)-ethylenediaminetetraacetic acid chelated anions on cross-linked, polyaminated chitosan beads

    SciTech Connect (OSTI)

    Juang, R.S.; Ju, C.Y.

    1998-08-01

    Rates of sorption of Cu(II)-ethylenediaminetetraacetic acid (EDTA) chelated anions from aqueous solutions on cross-linked, poly(ethylenimine) (PEI)-modified chitosan beads were measured in a batch stirred vessel. All experiments were carried out in an equimolar solution of Cu(II) and EDTA (0.47--3.15 mol/m{sup 3}). It was shown that the rates of sorption increased with an increase in the initial concentration of Cu(II), pH, and temperature but decreased with an increase in the molecular weight of PEI introduced in the beads. The widely used homogeneous diffusion model based on Fick`s law and the shrinking core model cannot describe the sorption process. On the contrary, the kinetic data were well fit by the Elovich equation. The apparent activation energies evaluated (3.5--8.4 kcal/mol at pH 3) indicated the combined film and particle diffusion mechanism.

  20. Toxic Substances Control Act (TSCA) chemical substances inventory: PMN number to EPA accession number link (for microcomputers). Data file

    SciTech Connect (OSTI)

    1995-11-01

    The PMN Number to EPA Accession Number Link Diskette provides a cross-reference of these numbers for commenced PMNs on the confidential portion of the TSCA Master Inventory File. Neither this cross-reference nor the additional information included is TSCA Confidential Business Information. Provided on the diskette for each confidential commenced PMN are the PMN Case Number, EPA Accession Number, Generic Name, and EPA special flags. The sequence of the file is in ascending PMN Case Number order with `P` case numbers sorted first, followed by `Y` case numbers. For more detailed information on the confidential portion of the TSCA Inventory, including generic names, users can consult the introductory material of the printed TSCA Inventory: 1985 Edition and its 1990 Supplement. New versions of this file may be issued in the future. No search software is provided with this DOS formatted diskette.

  1. Toxic Substances Control Act (TSCA) chemical substances inventory: PMN number to EPA accession number link (for microcomputers). Data file

    SciTech Connect (OSTI)

    Not Available

    1994-05-01

    The PMN Number to EPA Accession Number Link Diskette provides a cross-reference of these numbers for commenced PMNs on the confidential portion of the Toxic Substances Control Act (TSCA) Master Inventory File. Neither this cross-reference nor the additional information included is TSCA Confidential Business Information. Provided on the diskette for each confidential commenced PMN are the PMN Case Number, EPA Accession Number, Generic Name, and EPA special flags. For more detailed information on the confidential portion of the TSCA Inventory, including generic names, users can consult the introductory material of the printed TSCA Inventory: 1985 Edition and its 1990 Supplement. New versions of this file may be issued in the future.

  2. Is the surface oxygen exchange rate linked to bulk ion diffusivity in mixed conducting Ruddlesden–Popper phases?

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Tomkiewicz, Alex C.; Tamimi, Mazin A.; Huq, Ashfia; McIntosh, Steven

    2015-03-02

    There is a possible link between oxygen surface exchange rate and bulk oxygen anion diffusivity in mixed ionic and electronic conducting oxides; it is a topic of great interest and debate. While a large body of experimental evidence and theoretical analyses support a link, observed differences between bulk and surface composition of these materials are hard to reconcile with this observation. This is further compounded by potential problems with simultaneous measurement of both parameters. Here we utilize separate techniques, in situ neutron diffraction and pulsed isotopic surface exchange, to examine bulk ion mobility and surface oxygen exchange rates of threemore » Ruddlesden-Popper phases, general form An-1A2'BnO3n+1, An-1A2'BnX3n+1; LaSrCo0.5Fe0.5O4-δ (n = 1), La0.3Sr2.7CoFeO7-δ (n = 2) and LaSr3Co1.5Fe1.5O10-δ (n = 3). These measurements are complemented by surface composition determination via high sensitivity-low energy ion scattering. We observe a correlation between bulk ion mobility and surface exchange rate between materials. The surface exchange rates vary by more than one order of magnitude with high anion mobility in the bulk of an oxygen vacancy-rich n = 2 Ruddlesden-Popper material correlating with rapid oxygen exchange. Furthermore this is in contrast with the similar surface exchange rates which we may expect due to similar surface compositions across all three samples. This paper conclude that experimental limitations lead to inherent convolution of surface and bulk rates, and that surface exchange steps are not likely to be rate limiting in oxygen incorporation.« less

  3. Novel mutations in the connexin 32 gene associated with X-linked Charcot-Marie-Tooth disease

    SciTech Connect (OSTI)

    Tan, C.; Ainsworth, P. |

    1994-09-01

    Charcot-Marie-Tooth disease is a pathologically and genetically hetergenous group of disorders that cause a progressive neuropathy, defined pathologically by degeneration of the myelin (CMT 1) of the axon (CMT 2) of the peripheral nerves. An X-linked type of the demyelinating form of this disorder (CMT X) has recently been linked to mutations in the connexin 32 (Cx32) gene, which codes for a 284 amino acid gap junction protein found in myelinated peripheral nerve. To date some 7 different mutations in this gene have been identified as being responsible for CMT X. The majority of these predict nonconservative amino acid substitutions, while one is a frameshift mutation which predicts a premature stop at codon 21. We report the results of molecular studies on three further local CMT X kindreds. The Cx32 gene was amplified by PCR in three overlapping fragments 300-450 bp in length using leukocyte-derived DNA as template. These were either sequenced directly using a deaza dGTP sequencing protocol, or were cloned and sequenced using a TA vector. In two of the kindreds the affected members carried a point mutation which was predicted to effect a non-conservative amino acid change within the first transmembrane domain. Both of these mutations caused a restriction site alteration (the loss of an Nla III and the creation of a Pvu II, respectively), and the former mutation was observed to segregate with the clinicial phenotype in affected family members. Affected members of the third kindred, which was a very large multigenerational family that had been extensively studied previously, were shown to carry a point mutation predicted to cause a premature truncation of the Cx32 gene product in the intracellular carboxy terminus. This mutation obliterated an Rsa I site which allowed a rapid screen of several other family members.

  4. Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii

    SciTech Connect (OSTI)

    Miquel, Sylvie; Leclerc, Marion; Martin, Rebeca; Chain, Florian; Lenoir, Marion; Raguideau, Sébastien; Hudault, Sylvie; Bridonneau, Chantal; Northen, Trent; Bowen, Benjamin; Bermúdez-Humarán, Luis G.; Sokol, Harry; Thomas, Muriel; Langella, Philippe

    2015-04-21

    Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified on the basis of human clinical data. The mechanisms underlying its beneficial effects are still unknown. Gnotobiotic mice harboring F. prausnitzii (A2-165) and Escherichia coli (K-12 JM105) were subjected to 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute colitis. The inflammatory colitis scores and a gas chromatography-time of flight (GC/TOF) mass spectrometry-based metabolomic profile were monitored in blood, ileum, cecum, colon, and feces in gnotobiotic mice. The potential anti-inflammatory metabolites were tested in vitro. We obtained stable E. coli and F. prausnitzii-diassociated mice in which E. coli primed the gastrointestinal tract (GIT), allowing a durable and stable establishment of F. prausnitzii. The disease activity index, histological scores, myeloperoxidase (MPO) activity, and serum cytokine levels were significantly lower in the presence of F. prausnitzii after TNBS challenge. The protective effect of F. prausnitzii against colitis was correlated to its implantation level and was linked to overrepresented metabolites along the GIT and in serum. Among 983 metabolites in GIT samples and serum, 279 were assigned to known chemical reactions. Some of them, belonging to the ammonia (α-ketoglutarate), osmoprotective (raffinose), and phenolic (including anti-inflammatory shikimic and salicylic acids) pathways, were associated with a protective effect of F. prausnitzii, and the functional link was established in vitro for salicylic acid. We show for the first time that F. prausnitzii is a highly active commensal bacterium involved in reduction of colitis through in vivo modulation of metabolites along the GIT and in the peripheral blood.

  5. Bisfuel links - Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - talk at the Science for our Nation's Energy Future Summit, May 26, 2011 http:... Chu - Keynote Address at the Science for our Nation's Energy Future Summit, May 25, 2011

  6. Tunable thermal link

    DOE Patents [OSTI]

    Chang, Chih-Wei; Majumdar, Arunava; Zettl, Alexander K.

    2014-07-15

    Disclosed is a device whereby the thermal conductance of a multiwalled nanostructure such as a multiwalled carbon nanotube (MWCNT) can be controllably and reversibly tuned by sliding one or more outer shells with respect to the inner core. As one example, the thermal conductance of an MWCNT dropped to 15% of the original value after extending the length of the MWCNT by 190 nm. The thermal conductivity returned when the tube was contracted. The device may comprise numbers of multiwalled nanotubes or other graphitic layers connected to a heat source and a heat drain and various means for tuning the overall thermal conductance for applications in structure heat management, heat flow in nanoscale or microscale devices and thermal logic devices.

  7. A-Z Link

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Use or Search the A-Z Index (this page) 2. Use search.lbl.gov powered by Google. 3. Use DS The Directory of both People and Organizations Frequently Requested from the A-Z Index...

  8. astro_links.dvi

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    February 12, 2006 Abstract. Heavy ion experiments provide important data to test astrophysical models. The high density equation of state can be probed in HI collisions and applied to the hot protoneutron star formed in core collapse supernovae. The Parity Radius Experiment (PREX) aims to accurately measure the neutron radius of 208 Pb with parity violating electron scattering. This determines the pressure of neutron rich matter and the density dependence of the symmetry energy. Competition

  9. Helpful Links - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Repository (PIR) FOIA Administrative and Legal Contacts at Federal Agencies Agency contact list for offices other than the Department of Energy. Share on Last Updated 09172015 ...

  10. News Links | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brad Tippens, Dept. of Energy (March 16, 2011, A Message from Dr. Timothy Hallman, DOE) Jefferson Lab: Laser gun to eventually shoot down missiles (February 21, 2011, Daily Press) ...

  11. Weak-link capacitor

    DOE Patents [OSTI]

    Dirk, Shawn M.; Johnson, Ross S.; Wheeler, David R.; Bogart, Gregory R.

    2011-06-07

    A process for making a dielectric material where a precursor polymer selected from poly(phenylene vinylene) polyacetylene, poly(p-phenylene), poly(thienylene vinylene), poly(1,4-naphthylene vinylene), and poly(p-pyridine vinylene) is energized said by exposure by radiation or increase in temperature to a level sufficient to eliminate said leaving groups contained within the precursor polymer, thereby transforming the dielectric material into a conductive polymer. The leaving group in the precursor polymer can be a chloride, a bromide, an iodide, a fluoride, an ester, an xanthate, a nitrile, an amine, a nitro group, a carbonate, a dithiocarbamate, a sulfonium group, an oxonium group, an iodonium group, a pyridinium group, an ammonium group, a borate group, a borane group, a sulphinyl group, or a sulfonyl group.

  12. Weak-link capacitor

    DOE Patents [OSTI]

    Dirk, Shawn M.; Johnson, Ross S.; Wheeler, David R.; Bogart, Gregory R.

    2013-04-23

    A process for making a dielectric material where a precursor polymer selected from poly(phenylene vinylene)polyacetylene, poly(p-phenylene), poly(thienylene vinylene), poly(1,4-naphthylene vinylene), and poly(p-pyridine vinylene) is energized said by exposure by radiation or increase in temperature to a level sufficient to eliminate said leaving groups contained within the precursor polymer, thereby transforming the dielectric material into a conductive polymer. The leaving group in the precursor polymer can be a chloride, a bromide, an iodide, a fluoride, an ester, an xanthate, a nitrile, an amine, a nitro group, a carbonate, a dithiocarbamate, a sulfonium group, an oxonium group, an iodonium group, a pyridinium group, an ammonium group, a borate group, a borane group, a sulphinyl group, or a sulfonyl group.

  13. Link Alpha A

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    a A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z ABPDU (Advanced Biofuels Process Demonstration Unit) Accelerator Technology and Applied Physics Division (ATAP) Accident Report (Motor Vehicle) Accident Statistics Accident Statistics Archive Accommodations: Motels, Hotels and Housing for Visitors and Guests Accounts (new computer accounts) Accounts Payable (Disbursements)(processes payments and maintains records) Activity

  14. Link Alpha B

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  15. Link Alpha C

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  16. Link Alpha D

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  17. Link Alpha E

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    e A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Early Career Research Program Earth And Environmental Sciences Area eBuy (Firefox Recommended Browser) Ecology Department (EESA) Economic Impact Study ECR Ion Sources Educational Programs at the Lab EH&S Safety Training Electric Vehicle Charging Electrical Equipment Safety Program (EESP) Electrical Safety Manual Electrical Safety Program (PUB-3000 Chapter 8) Electrical

  18. Link Alpha F

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    f A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Facilities Division Facilities Lockshop Facilities Project Status Facilities Safety and Hazardous Waste Facilities Work Request Center Family Member Eligibility Verification Project FAQ on Computing Topics Financial Compliance Financial Management System (FMS 8.8 - FY14 and Prior) Financial Management System (FMS 9.2 - FY15+) Financial Management System (FMS) Help &

  19. Link Alpha G

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    g A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Gate Pass and Visitor Request Form (accessible only from onsite hosts) visitorpass.lbl.gov Gcal (Google Calendar) Gender Transition Guidelines, Workplace General Accounting Genome: DOE Joint Genome Institute Genomics: Visualization Tool for Alignments (VISTA) Geochemistry Department (EESA) Geophysics Department (EESA) GERT - General Employee Radiological Training (English)

  20. Link Alpha H

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    h A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Hands-on Universe (HOU) Program Harassment Prevention and Harassment Complaint Process HARP Hazard Management System (HMS) Hazardous Waste Requisition Health Services at the Lab (or call x6266) Heat Island Research Group Helios - harnessing the sun for a secure, sustainable, and prosperous future Help Desk (or call x4357) High Performance Computing Research Department Hire

  1. Link Alpha I

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    i A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Image Library Project Images - Release for Non-commercial Use Imaging and Distributed Computing Group (Home of the Whole Frog Project) Immigration Services Implicit Bias Improper Governmental Activities Reporting Incident Notification/Contact x6999 Indoor Air Quality Scientific Findings Resource Bank Indoor Air Quality, Inside Information Industrial Energy Analysis Industry

  2. Link Alpha J

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    j A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z JBEI: Joint BioEnergy Institute JCAP: Joint Center for Artificial Photosynthesis JDEM: The Joint Dark Energy Mission JGI: Joint Genome Institute Job Descriptions Job Hazards Analysis (JHA Help Center) Job Hazards Analysis (JHA Login page) Job Opening Request Jobs

  3. Link Alpha K

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    k A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Key Plans: Building Floor Plans Key Request: Facilities Lock Shop

  4. Link Alpha L

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    l A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z LabAlert - LabAlert Emergency Alerting Service Laboratory Counsel Laboratory Directed Research & Development Program (LDRD) Laboratory Property Review (LPR) Laboratory Support Services Lactation / Nursing Moms Lactation Accommodation Program Laser Ablation: Advanced Laser Technologies Lab Laser Management System (Laser Inventory) Laser Safety Web Page Lasers, Optical

  5. Link Alpha M

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    m A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Macintosh User Group (LBNL-MUG) Mail Services (Facilities Dep't.) Malware/Virus Protection and Prevention Mammary: Human Mammary Epithelial Cell (HMEC) Map: Berkeley Lab Global Talent Map Map: Lab Shuttle Bus Map Maps: Berkeley Lab Interactive Site Map Maps: Berkeley Lab Printable Site Map Massage Material Safety Data Sheets (Safety Data Sheets, SDS) Material Transfer

  6. Link Alpha N

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    n A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z National Health Survey NERSC: National Energy Research Scientific Computing Center Network Research Group New Employee Briefing New Employee Orientation & Training New Hire Request News Center News Releases: Subscribe to Lab News Email list Nobel Laureates Nondisclosure Agreements Notaries Public Nuclear Science Division (NSD) Nuclear Science: Relativistic Nuclear

  7. Link Alpha O

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    o A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Occurrence Reporting Off-site Storage Office of Contractor Assurance (OCA) Office of Institutional Assurance and Integrity (OIAI) Office of Planning and Strategic Development Office of Sponsored Projects and Industry Partnerships (OSPIP) - see OSPIP / IPO / OCFO Transition Office of the Chief Financial Officer (OCFO) Ombudsman - Technology Transfer / Innovation and

  8. Links - Cyclotron Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Faculty Websites Research Groups TAMU Websites On-Line Journals

  9. CAMD Nanofabrication Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Infrastructure :: News :: Related sites National Nanotechnology Initiative Nano Technology Industries Advanced Materials Research Institute Institute of Physics Max-Planck Institute for Kohlenforschung The institute of nanotechnology Nanotechnology Now Nanotechnology - Education Nanojournals Chancellor's Distinguished Lectureship Series

  10. Link Alpha Q

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    q A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Qualified Electrical Worker (QEW) Qualified Electrical Worker (QEW) Support Quality Assurance Quickbase (Electrical Safety Database)

  11. Link Alpha R

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    r A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Radiation Protection Group (EH&S) Radiation Safety Committee Charter Radiation Safety Committee Members Receiving Recovery Act (American Recovery and Reinvestment Act) Recruitment Recycling (Waste Minimization) Reflective X-Ray Optics Renewable Energy Report Coordination Report Submission and Search Reporting Portal (Cognos) (FY15+) Reporting Portal (Cognos) Help &

  12. Link Alpha S

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    s A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Safety Advisory Committee Safety and Hazardous Waste (Facilities Division) Safety Awards Safety Concerns Safety Culture Improvement Safety Data Sheets (SDS) Safety Walkthrough Management Salary Ranges Salvage (Waste Minimization) Scientific Cluster Support Scientific Networking Division Scientific Programs Seaborg: Glenn Seaborg's Life & Contributions Search lab-wide web

  13. Link Alpha T

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    t A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Tax Services Technical Area Designation Technology Transfer Department (Innovation and Partnerships Office) Technology Transfer Ombudsman Telecommuting Telemetry Database Telephone Service Center Termination Termination Notification System (TNS) Today at Berkeley Lab Tours of Berkeley Lab for the Public Traffic Safety Training (Berkeley Lab Training) Transit Passes

  14. Link Alpha U

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    u A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Unconscious Bias University/Hill Operations Center (Biosciences

  15. Link Alpha W

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    w A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z WageWorks Commuter Benefits for Lab Employees Walkthrough (Safety Management) Warehouse: see Off-site Storage Waste (Recycling and Composting) Waste Guide Waste Management Waste Minimization (Hazardous Waste) Weather Conditions at LBNL Web Job Order (WJO) Whistleblower Online Reporting Whistleblower Policy Windchill (Windchill Account Required, contact cad@lbl.gov) Windows

  16. Link Alpha Y

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    y A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Year End Close

  17. Link Alpha Z

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    z A B C D E F G H I J K L M N O P Q R S T U V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Zimride Zip + 4 (Zip codes for Berkeley Lab)

  18. Link Alpha V

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    v A B C D E F G H I J K L M N O P Q R S T V W Y Z Filter by alpha... A B C D E F G H I J K L M N O P Q R S T U V W Y Z Vacation Policy Vanpool Commuting Program for Employees...

  19. WIPP - Related Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    National Safety Council - Understanding Radiation NM Governor NMSU - Carlsbad Quality New Mexico TCC Support Website WERC Western Governor's Association Yucca Mountain Project

  20. Link Alpha P

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Particle Adventure: A Tour of the Atom & Tools for Discovery Particle Data Group (PDG) Password Reset Patent Group Payroll Department (CFO) PDSF: Parallel Distributed Systems ...

  1. Bisfuel links - EFRC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EFRC http://science.energy.gov/bes/efrc/centers/cbisfp/" target="_blank">BISFUEL page on the EFRC website http://www.energyfrontier.us/newsletter" target="_blank">Current issue of EFRC Newsletter http://science.energy.gov/bes/efrc/" target="_blank">DOE Energy Frontier Research Centers http://www.energyfrontier.us/sites/all/themes/basic/files/EFRC_Forum_Poster_Abstracts_web.pdf" target="_blank">EFRC 2011 Forum Poster

  2. Bisfuel links - Photosynthesis tag

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Photosynthesis tag http://biofuels.asu.edu/biomimetic.shtml" target="_blank">Artificial Photosynthesis http://bioenergy.asu.edu/photosyn/photoweb/" target="_blank">Photosynthesis online http://bioenergy.asu.edu/photosyn/references.html" target="_blank">Photosynthesis Reference sources http://bioenergy.asu.edu/photosyn/education/learn.html" target="_blank">What is photosynthesis?

  3. Bisfuel links - Professional organizations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Professional organizations http://portal.acs.org/portal/acs/corg/content" target="_blank">American Chemical Society

  4. Bisfuel links - Research centers

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research centers http://bioenergy.asu.edu/" target="_blank">Center for Bioenergy and Photosynthesis

  5. Bisfuel links - Seminars

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Seminars http://chemistry.asu.edu/seminar/seminar.asp" target="_blank">ASU Department of Chemistry Seminar http://bioenergy.asu.edu/seminars.html" target="_blank">Joint seminar series of the Center of Bioenergy and Photosynthesis and EFRC

  6. Bisfuel links - Video

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Video http://www.energyfrontier.us/content/agenda" target="_blank">EFRC 2011 Summit and Forum Materials (presentations and videos) http://www.energyfrontier.us/video-contest" target="_blank">EFRC video contest

  7. E-Link - Forms

    Office of Scientific and Technical Information (OSTI)

    If you have a Financial Assistance Agreement (e.g., a grant) or contract with the Department of Energy and have been asked to provide a final scientific and technical report, the accepted manuscript of a journal article, or other STI product, these are your submission options. For awards made on or after October 1, 2014, submission to DOE of accepted manuscripts is being required (see DOE STIP Public Access FAQs). Even if not specifically required under your award, you may submit an accepted

  8. Method and apparatus for routing data in an inter-nodal communications lattice of a massively parallel computer system by dynamic global mapping of contended links

    DOE Patents [OSTI]

    Archer, Charles Jens; Musselman, Roy Glenn; Peters, Amanda; Pinnow, Kurt Walter; Swartz, Brent Allen; Wallenfelt, Brian Paul

    2011-10-04

    A massively parallel nodal computer system periodically collects and broadcasts usage data for an internal communications network. A node sending data over the network makes a global routing determination using the network usage data. Preferably, network usage data comprises an N-bit usage value for each output buffer associated with a network link. An optimum routing is determined by summing the N-bit values associated with each link through which a data packet must pass, and comparing the sums associated with different possible routes.

  9. Electrical power inverter having a phase modulated, twin-inverter, high frequency link and an energy storage module

    DOE Patents [OSTI]

    Pitel, I.J.

    1987-02-03

    The present invention provides an electrical power inverter method and apparatus, which includes a high frequency link, for converting DC power into AC power. Generally stated, the apparatus includes a first high frequency module which produces an AC voltage at a first output frequency, and a second high frequency inverter module which produces an AC voltage at a second output frequency that is substantially the same as the first output frequency. The second AC voltage is out of phase with the first AC voltage by a selected angular phase displacement. A mixer mixes the first and second output voltages to produce a high frequency carrier which has a selected base frequency impressed on the sidebands thereof. A rectifier rectifies the carrier, and a filter filters the rectified carrier. An output inverter inverts the filtered carrier to produce an AC line voltage at the selected base frequency. A phase modulator adjusts the relative angular phase displacement between the outputs of the first and second high frequency modules to control the base frequency and magnitude of the AC line voltage. 19 figs.

  10. Cdc42p and Rho1p are sequentially activated and mechanistically linked to vacuole membrane fusion

    SciTech Connect (OSTI)

    Logan, Michael R.; Jones, Lynden; Eitzen, Gary

    2010-03-26

    Small monomeric GTPases act as molecular switches, regulating many biological functions via activation of membrane localized signaling cascades. Activation of their switch function is controlled by GTP binding and hydrolysis. Two Rho GTPases, Cdc42p and Rho1p, are localized to the yeast vacuole where they regulate membrane fusion. Here, we define a method to directly examine vacuole membrane Cdc42p and Rho1p activation based on their affinity to probes derived from effectors. Cdc42p and Rho1p showed unique temporal activation which aligned with distinct subreactions of in vitro vacuole fusion. Cdc42p was rapidly activated in an ATP-independent manner while Rho1p activation was kinetically slower and required ATP. Inhibitors that are known to block vacuole membrane fusion were examined for their effect on Cdc42p and Rho1p activation. Rdi1p, which inhibits the dissociation of GDP from Rho proteins, blocked both Cdc42p and Rho1p activation. Ligands of PI(4,5)P{sub 2} specifically inhibited Rho1p activation while pre-incubation with U73122, which targets Plc1p function, increased Rho1p activation. These results define unique activation mechanisms for Cdc42p and Rho1p, which may be linked to the vacuole membrane fusion mechanism.

  11. A Prospective Quasi-Randomized Comparison of Intraoperatively Built Custom-Linked Seeds Versus Loose Seeds for Prostate Brachytherapy

    SciTech Connect (OSTI)

    Ishiyama, Hiromichi; Satoh, Takefumi; Kawakami, Shogo; Tsumura, Hideyasu; Komori, Shouko; Tabata, Ken-ichi; Sekiguchi, Akane; Takahashi, Ryo; Soda, Itaru; Takenaka, Kouji; Iwamura, Masatsugu; Hayakawa, Kazushige

    2014-09-01

    Purpose: To compare dosimetric parameters, seed migration rates, operation times, and acute toxicities of intraoperatively built custom-linked (IBCL) seeds with those of loose seeds for prostate brachytherapy. Methods and Materials: Participants were 140 patients with low or intermediate prostate cancer prospectively allocated to an IBCL seed group (n=74) or a loose seed group (n=66), using quasirandomization (allocated by week of the month). All patients underwent prostate brachytherapy using an interactive plan technique. Computed tomography and plain radiography were performed the next day and 1month after brachytherapy. The primary endpoint was detection of a 5% difference in dose to 90% of prostate volume on postimplant computed tomography 1month after treatment. Seed migration was defined as a seed position >1cm from the cluster of other seeds on radiography. A seed dropped into the seminal vesicle was also defined as a migrated seed. Results: Dosimetric parameters including the primary endpoint did not differ significantly between groups, but seed migration rate was significantly lower in the IBCL seed group (0%) than in the loose seed group (55%; P<.001). Mean operation time was slightly but significantly longer in the IBCL seed group (57min) than in the loose seed group (50min; P<.001). No significant differences in acute toxicities were seen between groups (median follow-up, 9months). Conclusions: This prospective quasirandomized control trial showed no dosimetric differences between IBCL seed and loose seed groups. However, a strong trend toward decreased postimplant seed migration was shown in the IBCL seed group.

  12. Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization

    SciTech Connect (OSTI)

    Novak, Petr; Jensen, Taylor J.; Garbe, James C.; Stampfer, Martha R.; Futscher, Bernard W.

    2009-04-20

    The timing and progression of DNA methylation changes during carcinogenesis are not completely understood. To develop a timeline of aberrant DNA methylation events during malignant transformation, we analyzed genome-wide DNA methylation patterns in an isogenic human mammary epithelial cell (HMEC) culture model of transformation. To acquire immortality and malignancy, the cultured finite lifespan HMEC must overcome two distinct proliferation barriers. The first barrier, stasis, is mediated by the retinoblastoma protein and can be overcome by loss of p16(INK4A) expression. HMEC that escape stasis and continue to proliferate become genomically unstable before encountering a second more stringent proliferation barrier, telomere dysfunction due to telomere attrition. Rare cells that acquire telomerase expression may escape this barrier, become immortal, and develop further malignant properties. Our analysis of HMEC transitioning from finite lifespan to malignantly transformed showed that aberrant DNA methylation changes occur in a stepwise fashion early in the transformation process. The first aberrant DNA methylation step coincides with overcoming stasis, and results in few to hundreds of changes, depending on how stasis was overcome. A second step coincides with immortalization and results in hundreds of additional DNA methylation changes regardless of the immortalization pathway. A majority of these DNA methylation changes are also found in malignant breast cancer cells. These results show that large-scale epigenetic remodeling occurs in the earliest steps of mammary carcinogenesis, temporally links DNA methylation changes and overcoming cellular proliferation barriers, and provides a bank of potential epigenetic biomarkers that mayprove useful in breast cancer risk assessment.

  13. Characteristics of oligosaccharides from rat parotid (RP) N-linked glycoproteins (GP) after. beta. -adrenoreceptor (. beta. -AR) stimulation

    SciTech Connect (OSTI)

    Baum, B.J.; Yeh, C.K.; Kousvelari, E.E.

    1987-05-01

    The authors have shown that ..beta..-AR stimulation of RP cells leads to marked enhancement of N-linked glycosylation in 4 secretory GP (Mrapprox.220Kd, HMW;approx.32-38Kd, MMW;approx.17Kd, LMW). To characterize oligosaccharides in GP, cells were incubated 60 min +/- isoproterenol (ISO) and analyzed 2 ways. First, cell extracts were subjected to SDS-PAGE and Western blotting with peroxidase-conjugated Con A or wheat germ agglutinin (WGA). Second, double-labeled (/sup 3/H) man//sup 14/C leu) extracts were chromatographed on G200 followed by analysis of GP on Con A-Sepharose. HMW from control (CON) and ISO cells were Endo H insensitive, Endo F sensitive, altered by incubation with deoxynojirimycin (dNM), and bound both Con A and WGA conjugates. Similar findings were observed with LMW while MMW were sensitive to Endo H and Endo F, unaffected by dNM, bound Con A (strongly) and WGA (weakly). MMW and LMW were primarily eluted from Con A-Sepharose with 0.5M ..cap alpha..-methyl mannoside (..cap alpha..-MM) while HMW were eluted sequentially with 10 mM ..cap alpha..-methyl glucoside and ..cap alpha..-MM. HMW, MMW, and LMW had approx.4 fold higher /sup 3/H//sup 14/C ratios after ISO. These results suggest HMW and LMW likely contain biantennary complex and hybrid oligosaccharides while MMW contain only high mannose oligosaccharide types.

  14. Direct link between neutrinoless double beta decay and leptogenesis in a seesaw model with S{sub 4} symmetry

    SciTech Connect (OSTI)

    Ahn, Y. H. [Institute of Physics, Academia Sinica, Taipei 115, Taiwan (China); Kang, Sin Kyu [School of Liberal Arts, Seoul National Univ. of Technology, Seoul 139-743 (Korea, Republic of); Kim, C. S. [Department of Physics and IPAP, Yonsei University, Seoul 120-749 (Korea, Republic of); Nguyen, T. Phong [Department of Physics and IPAP, Yonsei University, Seoul 120-749 (Korea, Republic of); Department of Physics, Cantho University, Cantho (Viet Nam)

    2010-11-01

    We study how leptogenesis can be implemented in a seesaw model with S{sub 4} flavor symmetry, which leads to the neutrino tribimaximal mixing matrix and degenerate right-handed (RH) neutrino spectrum. Introducing a tiny soft S{sub 4} symmetry breaking term in the RH neutrino mass matrix, we show that the flavored resonant leptogenesis can be successfully realized, which can lower the seesaw scale much so, as to make it possible to probe in colliders. Even though such a tiny soft breaking term is essential for leptogenesis, it does not significantly affect the low-energy observables. We also investigate how the effective light neutrino mass || associated with neutrinoless double beta decay can be predicted along with the neutrino mass hierarchies by imposing experimental data of low-energy observables. We find a direct link between leptogenesis and neutrinoless double beta decay characterized by || through a high energy CP phase {phi}, which is correlated with low-energy Majorana CP phases. It is shown that our predictions of || for some fixed parameters of high energy physics can be constrained by the current observation of baryon asymmetry.

  15. On linking an Earth system model to the equilibrium carbon representation of an economically optimizing land use model

    SciTech Connect (OSTI)

    Bond-Lamberty, Benjamin; Calvin, Katherine V.; Jones, Andrew D.; Mao, Jiafu; Patel, Pralit L.; Shi, Xiaoying; Thomson, Allison M.; Thornton, Peter E.; Zhou, Yuyu

    2014-01-01

    Human activities are significantly altering biogeochemical cycles at the global scale, posing a significant problem for earth system models (ESMs), which may incorporate static land-use change inputs but do not actively simulate policy or economic forces. One option to address this problem is a to couple an ESM with an economically oriented integrated assessment model. Here we have implemented and tested a coupling mechanism between the carbon cycles of an ESM (CLM) and an integrated assessment (GCAM) model, examining the best proxy variables to share between the models, and quantifying our ability to distinguish climate- and land-use-driven flux changes. CLMs net primary production and heterotrophic respiration outputs were found to be the most robust proxy variables by which to manipulate GCAMs assumptions of long-term ecosystem steady state carbon, with short-term forest production strongly correlated with long-term biomass changes in climate-change model runs. By leveraging the fact that carbon-cycle effects of anthropogenic land-use change are short-term and spatially limited relative to widely distributed climate effects, we were able to distinguish these effects successfully in the model coupling, passing only the latter to GCAM. By allowing climate effects from a full earth system model to dynamically modulate the economic and policy decisions of an integrated assessment model, this work provides a foundation for linking these models in a robust and flexible framework capable of examining two-way interactions between human and earth system processes.

  16. Strengthening the link between project planning and environmental impact assessment : the assembled chemical weapons assessment dialogue process.

    SciTech Connect (OSTI)

    Goldberg, M. S.; Environmental Assessment

    2003-01-01

    An approach to stakeholder involvement known as the Dialogue process has been an integral part of the US Department of Defense Assembled Chemical Weapons Assessment (ACWA) Program from its inception. It has provided a means of soliciting stakeholder input before key decisions are made. The projects developed under the ACWA Program are characterized as major federal actions and therefore also must meet the requirements of the National Environmental Policy Act (NEPA). One of these is the requirement for public participation in the environmental impact assessment process. This case study describes the ACWA Dialogue and NEPA processes, and examines their relationship in the implementation of the ACWA Program. The examination suggests that involving the public at the beginning of a program through a Dialogue-like process can introduce environmental considerations early in the project development process and contribute to the development of a more informed public. These factors improve the overall efficacy of public participation, strengthening the link between project development and environmental assessment in a manner consistent with the original intent of NEPA.

  17. Electrical power inverter having a phase modulated, twin-inverter, high frequency link and an energy storage module

    DOE Patents [OSTI]

    Pitel, Ira J.

    1987-02-03

    The present invention provides an electrical power inverter method and apparatus, which includes a high frequency link, for converting DC power into AC power. Generally stated, the apparatus includes a first high frequency module which produces an AC voltage at a first output frequency, and a second high frequency inverter module which produces an AC voltage at a second output frequency that is substantially the same as the first output frequency. The second AC voltage is out of phase with the first AC voltage by a selected angular phase displacement. A mixer mixes the first and second output voltages to produce a high frequency carrier which has a selected base frequency impressed on the sidebands thereof. A rectifier rectifies the carrier, and a filter filters the rectified carrier. An output inverter inverts the filtered carrier to produce an AC line voltage at the selected base frequency. A phase modulator adjusts the relative angular phase displacement between the outputs of the first and second high frequency modules to control the base frequency and magnitude of the AC line voltage.

  18. New wholesale power market design using linked forward markets : a study for the DOE energy storage systems program.

    SciTech Connect (OSTI)

    Silva Monroy, Cesar Augusto; Loose, Verne William; Ellison, James F.; Elliott, Ryan Thomas; Byrne, Raymond Harry; Guttromson, Ross; Tesfatsion, Leigh S.

    2013-04-01

    This report proposes a reformulation of U.S. ISO/RTO-managed wholesale electric power mar- kets for improved reliability and e ciency of system operations. Current markets do not specify or compensate primary frequency response. They also unnecessarily limit the participation of new technologies in reserve markets and o er insu cient economic inducements for new capacity invest- ment. In the proposed market reformulation, energy products are represented as physically-covered rm contracts and reserve products as physically-covered call option contracts. Trading of these products is supported by a backbone of linked ISO/RTO-managed forward markets with planning horizons ranging from multiple years to minutes ahead. A principal advantage of this reformulation is that reserve needs can be speci ed in detail, and resources can o er the services for which they are best suited, without being forced to conform to rigid reserve product de nitions. This should improve the business case for electric energy storage and other emerging technologies to provide reserve. In addition, the facilitation of price discovery should help to ensure e cient energy/reserve procurement and adequate levels of new capacity investment.

  19. Assumption to the Annual Energy Outlook 2014 - Macroeconomic...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    in this module. A detailed description of the MAM is provided in the EIA publication, Model Documentation Report: Macroeconomic Activity Module (MAM) of the National Energy...

  20. Open Issues

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    October 2010 Resolved - Compiler Warning Message October 17, 2010 by Katie Antypas Description > ftn parHelloWorld.F90 /opt/cray/mpt/5.1.0/xt/gemini/mpich2-pgi/lib/libmpich.a(tcp_init.o): In function `MPID_nem_tcp_get_business_card': tcp_init.c:(.text+0x674): warning: Using 'gethostbyname' in statically linked applications requires at runtime the shared libraries from the glibc version used for linking

  1. Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: Linking systems biology with vaccine development

    SciTech Connect (OSTI)

    Adams, Leslie G.; Khare, Sangeeta; Lawhon, Sara D.; Rossetti, Carlos A.; Lewin, Harris A.; Lipton, Mary S.; Turse, Joshua E.; Wylie, Dennis C.; Bai, Yu; Drake, Kenneth L.

    2011-09-22

    The aim of research on infectious diseases is their prevention, and brucellosis and salmonellosis as such are classic examples of worldwide zoonoses for application of a systems biology approach for enhanced rational vaccine development. When used optimally, vaccines prevent disease manifestations, reduce transmission of disease, decrease the need for pharmaceutical intervention, and improve the health and welfare of animals, as well as indirectly protecting against zoonotic diseases of people. Advances in the last decade or so using comprehensive systems biology approaches linking genomics, proteomics, bioinformatics, and biotechnology with immunology, pathogenesis and vaccine formulation and delivery are expected to enable enhanced approaches to vaccine development. The goal of this paper is to evaluate the role of computational systems biology analysis of host:pathogen interactions (the interactome) as a tool for enhanced rational design of vaccines. Systems biology is bringing a new, more robust approach to veterinary vaccine design based upon a deeper understanding of the host pathogen interactions and its impact on the host's molecular network of the immune system. A computational systems biology method was utilized to create interactome models of the host responses to Brucella melitensis (BMEL), Mycobacterium avium paratuberculosis (MAP), Salmonella enterica Typhimurium (STM), and a Salmonella mutant (isogenic *sipA, sopABDE2) and linked to the basis for rational development of vaccines for brucellosis and salmonellosis as reviewed by Adams et al. and Ficht et al. [1,2]. A bovine ligated ileal loop biological model was established to capture the host gene expression response at multiple time points post infection. New methods based on Dynamic Bayesian Network (DBN) machine learning were employed to conduct a comparative pathogenicity analysis of 219 signaling and metabolic pathways and 1620 gene ontology (GO) categories that defined the host's biosignatures

  2. A recombination outside the BB deletion refines the location of the X-linked retinitis pigmentosa locus RP3

    SciTech Connect (OSTI)

    Fujita, R.; Bingham, E.; Forsythe, P.; McHenry, C.

    1996-07-01

    Genetic loci for X-linked retinitis pigmentosa (XLRP) have been mapped between Xp11.22 and Xp22.13 (RP2, RP3, RP6, and RP15). The RP3 gene, which is responsible for the predominant form of XLRP in most Caucasian populations, has been localized to Xp21.1 by linkage analysis and the map positions of chromosomal deletions associated with the disease. Previous linkage studies have suggested that RP3 is flanked by the markers DXS1110 (distal) and OTC (proximal). Patient BB was though to have RP because of a lesion at the RP3 locus, in addition to chronic granulomatous disease, Duchenne muscular dystrophy (DMD), mild mental retardation, and the McLeod phenotype. This patient carried a deletion extending {approximately}3 Mb from DMD in Xp21.3 to Xp21.1, with the proximal breakpoint located {approximately}40 kb centromeric to DXS1110. The RP3 gene, therefore, is believed to reside between DXS1110 and the proximal breakpoint of the BB deletion. In order to refine the location of RP3 and to ascertain patients with RP3, we have been analyzing several XLRP families for linkage to Xp markers. Linkage analysis in an American family of 27 individuals demonstrates segregation of XLRP with markers in Xp21.1, consistent with the RP3 subtype. One affected male shows a recombination event proximal to DXS1110. Additional markers within the DXS1110-OTC interval show that the crossover is between two novel polymorphic markers, DXS8349 and M6, both of which are present in BB DNA and lie centromeric to the proximal breakpoint. This recombination places the XLRP mutation in this family outside the BB deletion and redefines the location of RP3. 22 refs., 3 figs., 2 tabs.

  3. Radio-optical reference frame link using the U.S. Naval observatory astrograph and deep CCD imaging

    SciTech Connect (OSTI)

    Zacharias, N.; Zacharias, M. I.

    2014-05-01

    Between 1997 and 2004 several observing runs were conducted, mainly with the CTIO 0.9 m, to image International Celestial Reference Frame (ICRF) counterparts (mostly QSOs) in order to determine accurate optical positions. Contemporary to these deep CCD images, the same fields were observed with the U.S. Naval Observatory astrograph in the same bandpass. They provide accurate positions on the Hipparcos/Tycho-2 system for stars in the 10-16 mag range used as reference stars for the deep CCD imaging data. Here we present final optical position results of 413 sources based on reference stars obtained by dedicated astrograph observations that were reduced following two different procedures. These optical positions are compared to radio very long baseline interferometry positions. The current optical system is not perfectly aligned to the ICRF radio system with rigid body rotation angles of 3-5 mas (= 3σ level) found between them for all three axes. Furthermore, statistically, the optical-radio position differences are found to exceed the total, combined, known errors in the observations. Systematic errors in the optical reference star positions and physical offsets between the centers of optical and radio emissions are both identified as likely causes. A detrimental, astrophysical, random noise component is postulated to be on about the 10 mas level. If confirmed by future observations, this could severely limit the Gaia to ICRF reference frame alignment accuracy to an error of about 0.5 mas per coordinate axis with the current number of sources envisioned to provide the link. A list of 36 ICRF sources without the detection of an optical counterpart to a limiting magnitude of about R = 22 is provided as well.

  4. Multi-Path Transportation Futures Study: Vehicle Characterization and Scenario Analyses. Appendix E. Other NEMS-MP Results or the Base Case and Scenarios

    SciTech Connect (OSTI)

    Plotkin, Steve; Singh, Margaret; Patterson, Phil; Ward, Jake; Wood, Frances; Kydes, Niko; Holte, John; Moore, Jim; Miller, Grant; Das, Sujit; Greene, David

    2009-07-22

    This appendix examines additional findings beyond the primary results reported in the report for Phase 2 of the Multi-Path Transportation Futures Study.

  5. SPINE: SParse eIgengene NEtwork linking gene expression clusters in Dehalococcoides mccartyi to perturbations in experimental conditions

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mansfeldt, Cresten B.; Logsdon, Benjamin A.; Debs, Garrett E.; Richardson, Ruth E.; Mande, Shekhar C.

    2015-02-25

    We present a statistical model designed to identify the effect of experimental perturbations on the aggregate behavior of the transcriptome expressed by the bacterium Dehalococcoides mccartyi strain 195. Strains of Dehalococcoides are used in sub-surface bioremediation applications because they organohalorespire tetrachloroethene and trichloroethene (common chlorinated solvents that contaminate the environment) to non-toxic ethene. However, the biochemical mechanism of this process remains incompletely described. Additionally, the response of Dehalococcoides to stress-inducing conditions that may be encountered at field-sites is not well understood. The constructed statistical model captured the aggregate behavior of gene expression phenotypes by modeling the distinct eigengenes of 100more » transcript clusters, determining stable relationships among these clusters of gene transcripts with a sparse network-inference algorithm, and directly modeling the effect of changes in experimental conditions by constructing networks conditioned on the experimental state. Based on the model predictions, we discovered new response mechanisms for DMC, notably when the bacterium is exposed to solvent toxicity. The network identified a cluster containing thirteen gene transcripts directly connected to the solvent toxicity condition. Transcripts in this cluster include an iron-dependent regulator (DET0096-97) and a methylglyoxal synthase (DET0137). To validate these predictions, additional experiments were performed. Continuously fed cultures were exposed to saturating levels of tetrachloethene, thereby causing solvent toxicity, and transcripts that were predicted to be linked to solvent toxicity were monitored by quantitative reverse-transcription polymerase chain reaction. Twelve hours after being shocked with saturating levels of tetrachloroethene, the control transcripts (encoding for a key hydrogenase and the 16S rRNA) did not significantly change. By contrast, transcripts

  6. X-linked Alport syndrome: An SSCP-based mutation survey over all 51 exons of the COL4A5 gene

    SciTech Connect (OSTI)

    Renieri, A.; Bruttini, M.; Galli, L.; Ballabio, A.; De Marchi, M.

    1996-06-01

    The COL4A5 gene encodes the {alpha}5 (type IV) collagen chain and is defective in X-linked Alport syndrome (AS). Here, we report the first systematic analysis of all 51 exons of COL4A5 gene in a series of 201 Italian AS patients. We have previously reported nine major rearrangements, as well as 18 small mutations identified in the same patient series by SSCP analysis of several exons. After systematic analysis of all 51 exons of COL4A5, we have now identified 30 different mutations: 10 glycine substitutions in the triple helical domain of the protein, 9 frameshift mutations, 4 in-frame deletions, 1 start codon, 1 nonsense, and 5 splice-site mutations. These mutations were either unique or found in two unrelated families, thus excluding the presence of a common mutation in the coding part of the gene. Overall, mutations were detected in only 45% of individuals with a certain or likely diagnosis of X-linked AS. This finding suggests that mutations in noncoding segments of COL4A5 account for a high number of X-linked AS cases. An alternative hypothesis is the presence of locus heterogeneity, even within the X-linked form of the disease. A genotype/phenotype comparison enabled us to better substantiate a significant correlation between the degree of predicted disruption of the {alpha}5 chain and the severity of phenotype in affected male individuals. Our study has significant implications in the diagnosis and follow-up of AS patients. 44 refs., 3 figs., 4 tabs.

  7. On the nature of volume-phase transitions in photo-cross-linked poly(cyclopropylacrylamide) and poly(N-vinylisobutyramide) coatings

    SciTech Connect (OSTI)

    Patra, Leena; Messman, Jamie M; Toomey, Ryan G

    2013-01-01

    Ellipsometry in an inverted configuration was used to characterize the temperature-dependent swelling of thin (100 nm) coatings of photo-cross-linked poly(cyclopropylacrylamide), or poly(CPAAm), and poly(vinylisobutyramide), or poly(NVIBAm). Both polymers contained 3 mole % of methacroylaminobenzophenone (MnBP) as the photo-cross-linking unit. Poly(CPAAm-co-MnBP) showed a continuous, 2nd order deswelling transition between 10 and 70 oC with no hysteresis. Poly(NVIBAm), on the other hand showed a discontinuous, 1st order deswelling transition at 45 oC with a hysteresis in the swelling curve. The differences in the swelling transitions can be interpreted within the context of the cloud-point measurements of the uncross-linked polymers. Whereas poly(NVIBAm-co-MnBP) has a significant off-zero critical point (>10 wt% polymer) at 36oC, poly(CPAAm-co-MnBP) has a critical point at zero concentration and 23 oC. Concurrent measurements of the infrared vibrations of the amide groups in both polymers further revealed that the amide group in poly(CPAAm-co-MnBP) maintains a constant hydrogen-bonding environment throughout the volume-phase transition. Poly(NVIBAm-co-MnBP), on the other hand, has a concentration dependent hydrogen bonding environment around the carbonyl group, which is consistent with an off-zero concentration in the cloud point curve.

  8. Development of a New Class of Low Cost, High Frequency Link Direct DC to AC Converters for Solid Oxide Fuel Cells (SOFC)

    SciTech Connect (OSTI)

    Prasad Enjeti; J.W. Howze

    2003-12-01

    This project proposes to design and develop a new class of power converters (direct DC to AC) to drastically improve performance and optimize the cost, size, weight and volume of the DC to AC converter in SOFC systems. The proposed topologies employ a high frequency link; direct DC to AC conversion approach. The direct DC to AC conversion approach is more efficient and operates without an intermediate dc-link stage. The absence of the dc-link, results in the elimination of bulky, aluminum electrolytic capacitors, which in turn leads to a reduction in the cost, volume, size and weight of the power electronic converter. The feasibility of two direct DC to AC converter topologies and their suitability to meet SECA objectives will be investigated. Laboratory proto-type converters (3-5kW) will be designed and tested in Phase-1. A detailed design trade-off study along with the test results will be available in the form of a report for the evaluation of SECA Industrial partners. This project proposes to develop a new and innovative power converter technology suitable for Solid Oxide Fuel Cell (SOFC) power systems in accordance with SECA objectives. The proposed fuel cell inverter (FCI) employs state of the art power electronic devices configured in two unique topologies to achieve direct conversion of DC power (24-48V) available from a SOFC to AC power (120/240V, 60Hz) suitable for utility interface and powering stand alone loads. The primary objective is to realize cost effective fuel cell converter, which operates under a wide input voltage range, and output load swings with high efficiency and improved reliability.

  9. Toxic Substances Control Act (TSCA)-PMN file: ASCII text data. TSCA chemical substances inventory: PMN number to EPA accession number link, August 1996 (for microcomputers). Data file

    SciTech Connect (OSTI)

    1996-08-01

    The PMN Number to EPA Accession Number Link Diskette provides a cross-reference of these numbers for commenced PMNs on the confidential portion of the TSCA Master Inventory File. Neither this cross-reference nor the additional information included is TSCA Confidential Business Information. Provided on the diskette for each confidential commenced PMN are the PMN Case Number, EPA Accession Number, Generic Name, and EPA special flags. The sequence of the file is in ascending PMN case Number order with `P` case numbers sorted first, followed by `Y` case numbers.

  10. Self-replenishing ability of cross-linked low surface energy polymer films investigated by a complementary experimental-simulation approach

    SciTech Connect (OSTI)

    Esteves, A. C. C. E-mail: g.dewith@tue.nl; Lyakhova, K.; Riel, J. M. van; With, G. de E-mail: g.dewith@tue.nl; Ven, L. G. J. van der; Benthem, R. A. T. M. van

    2014-03-28

    Nowadays, many self-healing strategies are available for recovering mechanical damage of bulk polymeric materials. The recovery of surface-dependent functionalities on polymer films is, however, equally important and has been less investigated. In this work we study the ability of low surface energy cross-linked poly(ester urethane) networks containing perfluorinated dangling chains to self-replenish their surface, after being submitted to repeated surface damage. For this purpose we used a combined experimental-simulation approach. Experimentally, the cross-linked films were intentionally damaged by cryo-microtoming to remove top layers and create new surfaces which were characterized by water Contact Angle measurements and X-Ray Photoelectron Spectroscopy. The same systems were simultaneously represented by a Dissipative Particles Dynamics simulation method, where the damage was modeled by removing the top film layers in the simulation box and replacing it by new “air” beads. The influence of different experimental parameters, such as the concentration of the low surface energy component and the molecular mobility span of the dangling chains, on the surface recovery is discussed. The combined approach reveals important details of the self-replenishing ability of damaged polymer films such as the occurrence of multiple-healing events, the self-replenishing efficiency, and the minimum “healing agent” concentration for a maximum recovery.

  11. Effects of oxygen stoichiometry on the scaling behaviors of YBa{sub 2}Cu{sub 3}O{sub x} grain boundary weak-links

    SciTech Connect (OSTI)

    Wu, K.H.; Fu, C.M.; Jeng, W.J.

    1994-12-31

    The effects of oxygen stoichiometry on the transport properties of the pulsed laser deposited YBa{sub 2}Cu{sub 3}O{sub x} bicrystalline grain boundary weak-link junctions were studied. It is found that not only the cross boundary resistive transition foot structure can be manipulated repeatedly with oxygen annealling processes but the junction behaviors are also altered in accordance. In the fully oxygenated state i.e. with x=7.0 in YBa{sub 2}Cu{sub 3}O{sub x} stoichiometry, the junction critical current exhibits a power of 2 scaling behavior with temperature. In contrast, when annealed in the conditions of oxygen-deficient state (e.g. with x=6.9 in YBa{sub 2}Cu{sub 3}O{sub x} stoichiometry) the junction critical current switches to a linear temperature dependence behavior. The results are tentatively attributed to the modification of the structure in the boundary area upon oxygen annealing, which, in turn, will affect the effective dimension of the geometrically constrained weak-link bridges. The detailed discussion on the responsible physical mechanisms as well as the implications of the present results on device applications will be given.

  12. Localization to Xq22 and clinical update of a family with X-linked recessive mental retardation with progression sensorineural deafness, progressive tapeto-retinal degeneration and dystonia

    SciTech Connect (OSTI)

    Tranebjaerg, L.; Schwartz, C.; Huggins, K.; Barker, D.; Stevenson, R.; Arena, J.F.; Gedde-Dahl, T.; Mikkelsen, M.; Mellgren, S.; Anderson, K. ||||

    1994-07-15

    In a reinvestigation of a six-generation Norwegian family, originally reported with non-syndromic X-linked recessive deafness by Mohr and Mageroy, we have demonstrated several syndromic manifestations. The 10 clinically characterized affected males range in age from 14-61 years, and show progressive mental deterioration and visual disability. Ophthalmological and electrophysiological studies showed myopia, decreased visual acuity, combined cone-rod dystrophy as well as central areolar dystrophy by means of ERG. Brain CT-scans showed cortical and central atrophy without predilection to specific areas. Linkage analysis, using X-chromosomal RFLPs and CA-repeats, yielded a maximum LOD score of 4.37 with linkage to DXS17. DXS17 is localized to Xq22. One recombinant with COL4A5 (deficient in Alport syndrome) was observed. Results from the studies of this family will be important in reclassification of non-syndromic X-linked deafness since the family now represents syndromic deafness and XLMR with a specific phenotype.

  13. Notice of Availability (NOA) for the Draft Environmental Impact Statement (EIS) and Announcement of Public Hearings for the Proposed New England Clean Power Link (NECPL) Transmission Line: Federal Register Notice, Volume 80, No. 113- Jun. 12, 2015

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy (DOE) announces the availability of the “Draft Environmental Impact Statement for the New England Clean Power Link Transmission Line Project” (DOE/EIS-0503) for public review and comment.

  14. U.S. Energy Information Administration (EIA)

    Gasoline and Diesel Fuel Update (EIA)

    Policy Analysts This page features the most requested EIA reports and features for policy analysts. If you can't find what you're looking for, please contact the EIA Information Center. Featured Links Responses to Congressional and other requests Congressional testimony Analysis papers from Annual Energy Outlook Financial data and analysis Environmental data and analysis National Energy Modeling System (NEMS) documentation Energy in Brief Maps Featured Reports Annual Energy Outlook International

  15. U.S. ITER | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Policy Analysts This page features the most requested EIA reports and features for policy analysts. If you can't find what you're looking for, please contact the EIA Information Center. Featured Links Responses to Congressional and other requests Congressional testimony Analysis papers from Annual Energy Outlook Financial data and analysis Environmental data and analysis National Energy Modeling System (NEMS) documentation Energy in Brief Maps Featured Reports Annual Energy Outlook International

  16. Advanced Diagnostics and Life Estimation of Extruded Dielectric Cable: Nonproprietary Results Related to Cross-Linked Polyethylene and Ethylene Propylene Rubber Insulated Shielded Cables

    SciTech Connect (OSTI)

    G. Toman

    2006-03-31

    This report describes research on accelerated aging and diagnostic testing of cross-linked polyethylene (XLPE) insulation and an earlier test program on ethylene propylene rubber (EPR) cables. The XLPE research subjected cable specimens to accelerated cable life tests (ACLTs) and assessed the specimens with six nondestructive electrical tests and two destructive tests. The EPR program subjected EPR insulation to a similar accelerated aging protocol but focused on breakdown voltage to assess aging. Objectives ? To correlate advanced diagnostic test data with time-to-failure data as a means of determining the value of each diagnostic test for cable condition assessment and future life predictions (XLPE program) ? To perform accelerated aging tests of EPR insulated cables under various controlled conditions of temperature and voltage stress in a wet environment (EPR program) ? To ascertain the relative influence of temperature and voltage stress on aging (EPR program)

  17. Enriching regulatory networks by bootstrap learning using optimised GO-based gene similarity and gene links mined from PubMed abstracts

    SciTech Connect (OSTI)

    Taylor, Ronald C.; Sanfilippo, Antonio P.; McDermott, Jason E.; Baddeley, Robert L.; Riensche, Roderick M.; Jensen, Russell S.; Verhagen, Marc; Pustejovsky, James

    2011-02-18

    Transcriptional regulatory networks are being determined using “reverse engineering” methods that infer connections based on correlations in gene state. Corroboration of such networks through independent means such as evidence from the biomedical literature is desirable. Here, we explore a novel approach, a bootstrapping version of our previous Cross-Ontological Analytic method (XOA) that can be used for semi-automated annotation and verification of inferred regulatory connections, as well as for discovery of additional functional relationships between the genes. First, we use our annotation and network expansion method on a biological network learned entirely from the literature. We show how new relevant links between genes can be iteratively derived using a gene similarity measure based on the Gene Ontology that is optimized on the input network at each iteration. Second, we apply our method to annotation, verification, and expansion of a set of regulatory connections found by the Context Likelihood of Relatedness algorithm.

  18. Sandia`s network for Supercomputing `94: Linking the Los Alamos, Lawrence Livermore, and Sandia National Laboratories using switched multimegabit data service

    SciTech Connect (OSTI)

    Vahle, M.O.; Gossage, S.A.; Brenkosh, J.P.

    1995-01-01

    Supercomputing `94, a high-performance computing and communications conference, was held November 14th through 18th, 1994 in Washington DC. For the past four years, Sandia National Laboratories has used this conference to showcase and focus its communications and networking endeavors. At the 1994 conference, Sandia built a Switched Multimegabit Data Service (SMDS) network running at 44.736 megabits per second linking its private SMDS network between its facilities in Albuquerque, New Mexico and Livermore, California to the convention center in Washington, D.C. For the show, the network was also extended from Sandia, New Mexico to Los Alamos National Laboratory and from Sandia, California to Lawrence Livermore National Laboratory. This paper documents and describes this network and how it was used at the conference.

  19. Toxic Substances Control Act (TSCA) chemical substances inventory: PMN number to EPA accession number link, February 1996 (for microcomputers). Data file

    SciTech Connect (OSTI)

    1996-02-01

    The PMN Number to EPA Accession Number Link Diskette provides a cross-reference of these numbers for commenced PMNs on the confidential portion of the TSCA Master Inventory File. Neither this cross-reference nor the additional information included is TSCA Confidential Business Information. Provided on the diskette for each confidential commenced PMN are the PMN Case Number, EPA Accession Number, Generic Name, an EPA special flags. The sequence of the file is in ascending PMN case Number order with `P` case numbers sorted first, followed by `Y` case numbers. For more detailed information on the confidential portion of the TSCA Inventory, including generic names, users can consult the introductory material of the printed TSCA Inventory: 1985 Edition (PB87-129409) and its 1990 Supplement (PB91-159665 and PB91-145458). New versions of this file may be issued in the future. No search software is provided with this DOS formatted diskette.

  20. Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternative Conformation of NADPH that may be Linked to Trimethoprim Resistance

    SciTech Connect (OSTI)

    Frey, K.; Liu, J; Lombardo, M; Bolstad, D; Wright, D; Anderson, A

    2009-01-01

    Both hospital- and community-acquired Staphylococcus aureus infections have become major health concerns in terms of morbidity, suffering and cost. Trimethoprim-sulfamethoxazole (TMP-SMZ) is an alternative treatment for methicillin-resistant S. aureus (MRSA) infections. However, TMP-resistant strains have arisen with point mutations in dihydrofolate reductase (DHFR), the target for TMP. A single point mutation, F98Y, has been shown biochemically to confer the majority of this resistance to TMP. Using a structure-based approach, we have designed a series of novel propargyl-linked DHFR inhibitors that are active against several trimethoprim-resistant enzymes. We screened this series against wild-type and mutant (F98Y) S. aureus DHFR and found that several are active against both enzymes and specifically that the meta-biphenyl class of these inhibitors is the most potent. In order to understand the structural basis of this potency, we determined eight high-resolution crystal structures: four each of the wild-type and mutant DHFR enzymes bound to various propargyl-linked DHFR inhibitors. In addition to explaining the structure-activity relationships, several of the structures reveal a novel conformation for the cofactor, NADPH. In this new conformation that is predominantly associated with the mutant enzyme, the nicotinamide ring is displaced from its conserved location and three water molecules complete a network of hydrogen bonds between the nicotinamide ring and the protein. In this new position, NADPH has reduced interactions with the inhibitor. An equilibrium between the two conformations of NADPH, implied by their occupancies in the eight crystal structures, is influenced both by the ligand and the F98Y mutation. The mutation induced equilibrium between two NADPH-binding conformations may contribute to decrease TMP binding and thus may be responsible for TMP resistance.

  1. A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b

    SciTech Connect (OSTI)

    Sano, Hiroyuki; Peck, Grantley R.; Blachon, Stephanie; Lienhard, Gustav E.

    2015-09-25

    Insulin increases glucose transport in fat and muscle cells by stimulating the exocytosis of specialized vesicles containing the glucose transporter GLUT4. This process, which is referred to as GLUT4 translocation, increases the amount of GLUT4 at the cell surface. Previous studies have provided evidence that insulin signaling increases the amount of Rab10-GTP in the GLUT4 vesicles and that GLUT4 translocation requires the exocyst, a complex that functions in the tethering of vesicles to the plasma membrane, leading to exocytosis. In the present study we show that Rab10 in its GTP form binds to Exoc6 and Exoc6b, which are the two highly homologous isotypes of an exocyst subunit, that both isotypes are found in 3T3-L1 adipocytes, and that knockdown of Exoc6, Exoc6b, or both inhibits GLUT4 translocation in 3T3-L1 adipocytes. These results suggest that the association of Rab10-GTP with Exoc6/6b is a molecular link between insulin signaling and the exocytic machinery in GLUT4 translocation. - Highlights: • Insulin stimulates the fusion of vesicles containing GLUT4 with the plasma membrane. • This requires vesicular Rab10-GTP and the exocyst plasma membrane tethering complex. • We find that Rab10-GTP associates with the Exoc6 subunit of the exocyst. • We find that knockdown of Exoc6 inhibits fusion of GLUT4 vesicles with the membrane. • The interaction of Rab10-GTP with Exoc6 potentially links signaling to exocytosis.

  2. Model documentation: Natural gas transmission and distribution model of the National Energy Modeling System. Volume 1

    SciTech Connect (OSTI)

    1995-02-17

    The Natural Gas Transmission and Distribution Model (NGTDM) is the component of the National Energy Modeling System (NEMS) that is used to represent the domestic natural gas transmission and distribution system. NEMS was developed in the Office of integrated Analysis and Forecasting of the Energy information Administration (EIA). NEMS is the third in a series of computer-based, midterm energy modeling systems used since 1974 by the EIA and its predecessor, the Federal Energy Administration, to analyze domestic energy-economy markets and develop projections. The NGTDM is the model within the NEMS that represents the transmission, distribution, and pricing of natural gas. The model also includes representations of the end-use demand for natural gas, the production of domestic natural gas, and the availability of natural gas traded on the international market based on information received from other NEMS models. The NGTDM determines the flow of natural gas in an aggregate, domestic pipeline network, connecting domestic and foreign supply regions with 12 demand regions. The methodology employed allows the analysis of impacts of regional capacity constraints in the interstate natural gas pipeline network and the identification of pipeline capacity expansion requirements. There is an explicit representation of core and noncore markets for natural gas transmission and distribution services, and the key components of pipeline tariffs are represented in a pricing algorithm. Natural gas pricing and flow patterns are derived by obtaining a market equilibrium across the three main elements of the natural gas market: the supply element, the demand element, and the transmission and distribution network that links them. The NGTDM consists of four modules: the Annual Flow Module, the Capacity F-expansion Module, the Pipeline Tariff Module, and the Distributor Tariff Module. A model abstract is provided in Appendix A.

  3. Bisfuel links - Solar energy news

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Solar energy news http:asulightworks.com" target"blank">ASU Lightworks http:www.sciencedaily.comnewsmatterenergysolarenergy" target"blank">ScienceDaily: Solar Energy ...

  4. TAMU Websites - Links - Cyclotron Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TAMU Websites Texas A&M University College of Science Department of Chemistry Department of Physics and Astronomy...

  5. NREL: Energy Analysis - Related Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Department of Energy's Federal Energy Management Program (FEMP) team at the National ... FEMP also can assist you in selecting renewable energy and distributed power technologies ...

  6. Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Information about marine and hydrokinetic resources, government activities and research, water power associations and organizations, learning activities, and homeowner resources ...

  7. astro_links2.dvi

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    April 6, 2006 Abstract. Heavy ion experiments provide important data to test astrophysical models. The high density equation of state can be probed in HI collisions and applied to the hot protoneutron star formed in core collapse supernovae. The Parity Radius Experiment (PREX) aims to accurately measure the neutron radius of 208 Pb with parity violating electron scattering. This determines the pressure of neutron rich matter and the density dependence of the symmetry energy. Competition between

  8. Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The Case for a National Manufacturing Strategy, The Information Technology and Innovation Foundation, April 2011. Legislative and Executive Guidance P.L. 109-58, "Energy Policy Act ...

  9. Biosafety Links | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Animal and Plant Health Inspection Service (APHIS) Forms Infectious Agents ... Security Emergency Management Issues Special Interest Group Mesothelioma Group NIH Office of ...

  10. Biomass energies: resources, links, constraints

    SciTech Connect (OSTI)

    Smil, V.

    1983-01-01

    This book presents information on the following topics: radiation and photosynthesis; primary production and biomass; resources; wood for energy; silviculture; requirements and effects; crop residues; residues for energy conversion; sugar crops and grain; cassava; fuel crops; aquatic plants; freshwater plants; ocean algae; animal wastes; Chinese biogas generation; and ecodisasters.

  11. EIA - Related Links for Transportation

    U.S. Energy Information Administration (EIA) Indexed Site

    information about American society, political processes, official U.S. policies and culture. U.S. Department of the Treasury IRS and Treasury Provide Guidance to Hybrid...

  12. Department of Energy Idaho - Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ICP Idaho Completion Project INL Idaho National Laboratory Citizen's Advisory Board (CAB) Higher Education - INRA State & Local National Environmental Policy Act (NEPA) Office...

  13. RADRELAY RADIOLOGICAL DATA LINK DEVICE

    SciTech Connect (OSTI)

    Harpring, L; Frank Heckendorn, F

    2007-11-06

    The RadRelay effort developed small, field appropriate, portable prototype devices that allow radiological spectra to be downloaded from field radiological detectors, like the identiFINDER-U, and transmitted to land based experts. This communications capability was designed for the U. S. Coast Guard (USCG) but is also applicable to the Customs and Border Protection (CBP) personnel working in remote locations. USCG Level II personnel currently use the identiFINDER-U Hand-Held Radioisotope ID Devices (HHRIID) to detect radiological materials during specific boarding operations. These devices will detect not only radiological emissions but will also evaluate those emissions against a table of known radiological spectra. The RadRelay has been developed to significantly improve the functionality of HHRIID, by providing the capability to download radiological spectra and then transmit them using satellite or cell phone technology. This remote wireless data transfer reduces the current lengthy delay often encountered between the shipboard detection of unknown radiological material and the evaluation of that data by technical and command personnel. That delay is reduced from hours to minutes and allows the field located personnel to remain on station during the inspection and evaluation process.

  14. Related Links | Department of Energy

    Office of Environmental Management (EM)

    Coordinating Collaborative Utility Wind Integration Group Bats and Wind Energy Cooperative American Wind Wildlife Institute International British Wind Energy Association Canadian ...

  15. Bisfuel links - Arizona State University

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Arizona State University http://chemistry.asu.edu/" target="_blank">ASU Department of Chemistry and Biochemistry http://sustainability.asu.edu/index.php" target="_blank">ASU Global Institute of Sustainability http://asulightworks.com/" target="_blank">ASU Lightworks http://sols.asu.edu/" target="_blank">ASU School of Life Sciences http://www.biodesign.asu.edu/" target="_blank">Biodesign Institute

  16. Bisfuel links - Department of Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Department of Energy http://science.energy.gov/" target="_blank">Department of Energy Office of Science http://science.energy.gov/bes/efrc/" target="_blank">DOE Energy Frontier Research Centers http://science.energy.gov/bes/efrc/research/grand-challenges/" target="_blank">Grand challenges of the DOE and EFRC http://www.energyfrontier.us/sites/all/themes/frontiers/pdfs/Dehmer_Presentation.pdf" target="_blank">Pat Dehmer -

  17. Identification of a distinct type IV collagen. alpha. chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome

    SciTech Connect (OSTI)

    Hostikka, S.L.; Hoeyhtyae, M.; Tryggvason, K. ); Eddy, R.L.; Byers, M.G.; Shows, T.B. )

    1990-02-01

    The authors have identified and extensively characterized a type IV collagen {alpha} chain, referred to as {alpha}5(IV). Four overlapping cDNA clones isolated contain an open reading frame for 543 amino acid residues of the carboxyl-terminal end of a collagenous domain, a 229-residue carboxyl-terminal noncollagenous domain, and 1201 base pairs coding for a 3{prime} untranslated region. The collagenous Gly-Xaa-Yaa repeat sequence has five imperfections that coincide with those in the corresponding region of the {alpha}1(IV) chain. The noncollagenous domain has 12 conserved cysteine residues and 83% and 63% sequence identity with the noncollagenous domains of the {alpha}1(IV) and {alpha}2(IV) chains, respectively. The {alpha}5(IV) chain has less sequence identity with the putative bovine {alpha}3(IV) and {alpha}4(IV) chains. Antiserum against an {alpha}5(IV) synthetic peptide stained a polypeptide chain of about 185 kDa by immunoblot analysis and immunolocalization of the chain in human kidney was almost completely restricted to the glomerulus. The gene was assigned to the Xq22 locus by somatic cell hybrids and in situ hybridization. This may be identical or close to the locus of the X chromosome-linked Alport syndrome that is believed to be a type IV collagen disease.

  18. 2009 PowerPoint Template Presentation Title Style 1

    U.S. Energy Information Administration (EIA) Indexed Site

    RPS Scenarios NEMS NESSIE NEMS Inputs * Energy System Characteristics * Fuel Cost Models * ...limitations (esp. biomass) * Energy storage, gas backup or integration issues? * ...

  19. Assumptions to Annual Energy Outlook - Energy Information Administrati...

    Gasoline and Diesel Fuel Update (EIA)

    also are evaluated for convergence. Each NEMS component represents the effects and costs of legislation and environmental regulations that affect that sector. NEMS accounts...

  20. SPINE: SParse eIgengene NEtwork linking gene expression clusters in Dehalococcoides mccartyi to perturbations in experimental conditions

    SciTech Connect (OSTI)

    Mansfeldt, Cresten B.; Logsdon, Benjamin A.; Debs, Garrett E.; Richardson, Ruth E.; Mande, Shekhar C.

    2015-02-25

    We present a statistical model designed to identify the effect of experimental perturbations on the aggregate behavior of the transcriptome expressed by the bacterium Dehalococcoides mccartyi strain 195. Strains of Dehalococcoides are used in sub-surface bioremediation applications because they organohalorespire tetrachloroethene and trichloroethene (common chlorinated solvents that contaminate the environment) to non-toxic ethene. However, the biochemical mechanism of this process remains incompletely described. Additionally, the response of Dehalococcoides to stress-inducing conditions that may be encountered at field-sites is not well understood. The constructed statistical model captured the aggregate behavior of gene expression phenotypes by modeling the distinct eigengenes of 100 transcript clusters, determining stable relationships among these clusters of gene transcripts with a sparse network-inference algorithm, and directly modeling the effect of changes in experimental conditions by constructing networks conditioned on the experimental state. Based on the model predictions, we discovered new response mechanisms for DMC, notably when the bacterium is exposed to solvent toxicity. The network identified a cluster containing thirteen gene transcripts directly connected to the solvent toxicity condition. Transcripts in this cluster include an iron-dependent regulator (DET0096-97) and a methylglyoxal synthase (DET0137). To validate these predictions, additional experiments were performed. Continuously fed cultures were exposed to saturating levels of tetrachloethene, thereby causing solvent toxicity, and transcripts that were predicted to be linked to solvent toxicity were monitored by quantitative reverse-transcription polymerase chain reaction. Twelve hours after being shocked with saturating levels of tetrachloroethene, the control transcripts (encoding for a key hydrogenase and the 16S rRNA) did not significantly change. By contrast