National Library of Energy BETA

Sample records for maintaining essential functions

  1. Office of Legal Counsel U.S. Department of Justice **1 *290 MAINTAINING ESSENTIAL SERVICES IN THE DISTRICT OF COLUMBIA IN THE EVENT

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 U.S. Op. Off. Legal Counsel 290, 1988 WL 391023 (O.L.C.) Office of Legal Counsel U.S. Department of Justice **1 *290 MAINTAINING ESSENTIAL SERVICES IN THE DISTRICT OF COLUMBIA IN THE EVENT APPROPRIATIONS CEASE December 15, 1988 When the District of Columbia is otherwise prohibited by law from spending its appropriation, the District's Mayor is authorized under the Anti-Deficiency Act to expend moneys necessary to maintain government services bearing a reasonable relationship to the safety of

  2. Essential Systems Functionality Inspection Criteria, Approach, and Lines of Inquiry, October 16, 2008 (HSS CRAD 64-11 Rev. 2)

    Broader source: Energy.gov [DOE]

    The Essential Systems Functionality (ESF) inspection will evaluate the effectiveness of programs and processes for engineering design and safety basis, construction and installation, configuration management, surveillance testing, maintenance, operations, cognizant system engineer (CSE) and safety system oversight (SSO), and feedback and improvement of selected safety systems. This review will evaluate the effectiveness in maintaining the functionality of these safety systems. The ESF review will be performed in the context of integrated safety management (ISM), although the inspection criteria, activities and lines of inquiry are organized by ESF functional areas rather than ISM principles and core functions.

  3. 8-Oxoguanine DNA glycosylase 1 (ogg1) maintains the function of cardiac progenitor cells during heart formation in zebrafish

    SciTech Connect (OSTI)

    Yan, Lifeng; Zhou, Yong; Yu, Shanhe; Ji, Guixiang; Liu, Wei; Gu, Aihua

    2013-11-15

    Genomic damage may devastate the potential of progenitor cells and consequently impair early organogenesis. We found that ogg1, a key enzyme initiating the base-excision repair, was enriched in the embryonic heart in zebrafish. So far, little is known about DNA repair in cardiogenesis. Here, we addressed the critical role of ogg1 in cardiogenesis for the first time. ogg1 mainly expressed in the anterior lateral plate mesoderm (ALPM), the primary heart tube, and subsequently the embryonic myocardium by in situ hybridisation. Loss of ogg1 resulted in severe cardiac morphogenesis and functional abnormalities, including the short heart length, arrhythmia, decreased cardiomyocytes and nkx2.5{sup +} cardiac progenitor cells. Moreover, the increased apoptosis and repressed proliferation of progenitor cells caused by ogg1 deficiency might contribute to the heart phenotype. The microarray analysis showed that the expression of genes involved in embryonic heart tube morphogenesis and heart structure were significantly changed due to the lack of ogg1. Among those, foxh1 is an important partner of ogg1 in the cardiac development in response to DNA damage. Our work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish. These findings may be helpful for understanding the aetiology of congenital cardiac deficits. - Highlights: A key DNA repair enzyme ogg1 is expressed in the embryonic heart in zebrafish. We found that ogg1 is essential for normal cardiac morphogenesis in zebrafish. The production of embryonic cardiomyocytes requires appropriate ogg1 expression. Ogg1 critically regulated proliferation of cardiac progenitor cells in zebrafish. foxh1 is a partner of ogg1 in the cardiac development in response to DNA damage.

  4. Maintaining STAR - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Getting Started Maintaining STAR VPP CampaignPosters VPP Tools VPP Presentations VPP Awareness VPP Communications VPP Conferences Maintaining STAR Email Email Page | Print Print...

  5. Maintaining System Air Quality

    Office of Energy Efficiency and Renewable Energy (EERE)

    This tip sheet discusses how to maintain air quality in compressed air systems through proper use of equipment.

  6. Installing and Maintaining a Home Solar Electric System | Department...

    Energy Savers [EERE]

    Making sure your home solar electric or photovoltaic (PV) system is sized, sited, installed, and maintained correctly is essential for maximizing its energy performance. When...

  7. Cardiolipin Deficiency in Rhodobacter sphaeroides Alters the Lipid Profile of Membranes and of Crystallized Cytochrome Oxidase, but Structure and Function Are Maintained

    SciTech Connect (OSTI)

    Zhang, Xi; Tamot, Banita; Hiser, Carrie; Reid, Gavin E.; Benning, Christoph; Ferguson-Miller, Shelagh

    2012-05-08

    Many recent studies highlight the importance of lipids in membrane proteins, including in the formation of well-ordered crystals. To examine the effect of changes in one lipid, cardiolipin, on the lipid profile and the production, function, and crystallization of an intrinsic membrane protein, cytochrome c oxidase, we mutated the cardiolipin synthase (cls) gene of Rhodobacter sphaeroides, causing a >90% reduction in cardiolipin content in vivo and selective changes in the abundances of other lipids. Under these conditions, a fully native cytochrome c oxidase (CcO) was produced, as indicated by its activity, spectral properties, and crystal characteristics. Analysis by MALDI tandem mass spectrometry (MS/MS) revealed that the cardiolipin level in CcO crystals, as in the membranes, was greatly decreased. Lipid species present in the crystals were directly analyzed for the first time using MS/MS, documenting their identities and fatty acid chain composition. The fatty acid content of cardiolipin in R. sphaeroides CcO (predominantly 18:1) differs from that in mammalian CcO (18:2). In contrast to the cardiolipin dependence of mammalian CcO activity, major depletion of cardiolipin in R. sphaeroides did not impact any aspect of CcO structure or behavior, suggesting a greater tolerance of interchange of cardiolipin with other lipids in this bacterial system.

  8. Maintaining gas cooling equipment

    SciTech Connect (OSTI)

    Rector, J.D.

    1997-05-01

    An often overlooked key to satisfactory operation and longevity of any mechanical device is proper operation and maintenance in accordance with the manufacturer`s written instructions. Absorption chillers, although they use a different technology than the more familiar vapor compression cycle to produce chilled water, operate successfully in a variety of applications if operated and maintained properly. Maintenance procedures may be more frequent than those required for vapor compression chillers, but they are also typically less complex. The goal of this article is to describe the basic operation of an absorption chiller to provide an understanding of the relatively simple tasks required to keep the machine operating at maximum efficiency for its design life and beyond. A good starting point is definitions. Gas cooling equipment is generally defined as alternative energy, non-electric cooling products. This includes absorption chillers, engine-drive chillers and packaged desiccant units, among others. Natural gas combustion drives the equipment.

  9. Tank farms essential drawing plan

    SciTech Connect (OSTI)

    Domnoske-Rauch, L.A.

    1998-08-04

    The purpose of this document is to define criteria for selecting Essential Drawings, Support Drawings, and Controlled Print File (CPF) drawings and documents for facilities that are part of East and West Tank Farms. Also, the drawings and documents that meet the criteria are compiled separate listings. The Essential Drawing list and the Support Drawing list establish a priority for updating technical baseline drawings. The CPF drawings, denoted by an asterisk (*), defined the drawings and documents that Operations is required to maintain per the TWRS Administration Manual. The Routing Boards in Buildings 272-WA and 272-AW are not part of the CPF.

  10. Maintain Pumping Systems Effectively | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Maintain Pumping Systems Effectively Maintain Pumping Systems Effectively This tip sheet offers preventive and predictive actions to effectively maintain pumping systems. PUMPING ...

  11. Maintaining the Stockpile | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Maintaining the Stockpile NNSA Hosts NPT Parties at Los Alamos and Sandia National Laboratories WASHINGTON D.C. - On March 25-27, 2015, the National Nuclear Security Administration (NNSA) hosted representatives from 11 States Parties to the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) and one representative from the United Nations Office for Disarmament Affairs. The... Flight Test of Weapons System Body by Navy Successful Third Flight Demonstrated Dynamics and Functional Performance

  12. Policy Memorandum #9 - Establishing and Maintaining Competitive...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    9 - Establishing and Maintaining Competitive Level Codes Policy Memorandum 9 - Establishing and Maintaining Competitive Level Codes PDF icon Policy Memorandum 9 - Establishing...

  13. Hydroelectric redevelopment maintains heritage values

    SciTech Connect (OSTI)

    Bulkovshteyn, L.; Chidiac, M.; Hall, W.

    1995-12-31

    The Seymour GS is an 80 year old generating station on the historic Trent-Severn Waterway in Ontario, Canada. The rehabilitation at Seymour was approved by Provincial and Federal authorities on condition that the original appearance of the building be maintained. The capacity of the Generating Station (GS) is being uprated from 3.15 MW to 5.7 MW, by replacing five vertical double runner Francis units with five horizontal Kaplan turbines. The replacement of vertical Francis units with horizontal Kaplan units, necessitated an extensive and innovative demolition approach for the substructure modification. The new turbines required a powerhouse base slab 3.5 m below the grade of the original slab. This required removal of the existing slabs and foundation rock along with most of the interior powerhouse walls. The type of modification and demolition were carefully chosen to accommodate a very tight schedule dictated by the requirement of the Federal Department of Fisheries and Oceans (DFO), where in-water work is restricted to certain months of the year.

  14. SPONAP Grant Writing Essentials

    Broader source: Energy.gov [DOE]

    HUD's Southern Plains Office of Native American Programs in collaboration with the Seminole Tribe of Florida Native Learning Center invites you to attend the Grant Writing Essentials training...

  15. Maintaining the Stockpile | National Nuclear Security Administration |

    National Nuclear Security Administration (NNSA)

    (NNSA) Maintaining the Stockpile NNSA ensures the Nation sustains a safe, secure, and effective nuclear deterrent through the application of science, technology, engineering, and manufacturing. To deal with the changing face of nuclear deterrence and more-widely dispersed nuclear knowledge, NNSA also ensures the United States maintains excellence in nuclear science and technology that is second to none. Within the Nuclear Security Enterprise, the central mission which includes maintaining

  16. Recommendation 220: Recommendation Regarding Maintaining Funding...

    Energy Savers [EERE]

    Regarding Maintaining Funding for Cleanup The Environmental Management Site-Specific Advisory Board recommends that DOE make every effort possible, including addressing...

  17. Maintaining System Air Quality | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Maintaining System Air Quality (August 2004) More Documents & Publications Remove Condensate with Minimal Air Loss Engineer End Uses for Maximum Efficiency Stabilizing System...

  18. Encapsulation method for maintaining biodecontamination activity

    DOE Patents [OSTI]

    Rogers, Robert D.; Hamilton, Melinda A.; Nelson, Lee O.; Benson, Jennifer; Green, Martin J.; Milner, Timothy N.

    2006-04-11

    A method for maintaining the viability and subsequent activity of microorganisms utilized in a variety of environments to promote biodecontamination of surfaces. One application involves the decontamination of concrete surfaces. Encapsulation of microbial influenced degradation (MID) microorganisms has shown that MID activity is effectively maintained under passive conditions, that is, without manual addition of moisture or nutrients, for an extended period of time.

  19. Encapsulation method for maintaining biodecontamination activity

    DOE Patents [OSTI]

    Rogers, Robert D.; Hamilton, Melinda A.; Nelson, Lee O.; Benson, Jennifer; Green, Martin J.; Milner, Timothy N.

    2002-01-01

    A method for maintaining the viability and subsequent activity of microorganisms utilized in a variety of environments to promote biodecontamination of surfaces. One application involves the decontamination of concrete surfaces. Encapsulation of microbial influenced degradation (MID) microorganisms has shown that MID activity is effectively maintained under passive conditions, that is, without manual addition of moisture or nutrients, for an extended period of time.

  20. Energy Literacy Essential Principle #1

    SciTech Connect (OSTI)

    2014-12-02

    Energy Literacy Essential Principle #1: Energy is a physical quantity that follows precise natural laws.

  1. Energy Literacy Essential Principle #5

    SciTech Connect (OSTI)

    2015-03-11

    Energy Literacy Essential Principle #5: Energy decisions are influenced by economic, political, environmental, and social factors.

  2. Energy Literacy Essential Principle #3

    SciTech Connect (OSTI)

    2014-12-02

    Energy Literacy Essential Principle #3: Biological processes depend on energy flow through the Earth system.

  3. Maintaining ideal body weight counseling sessions

    SciTech Connect (OSTI)

    Brammer, S.H.

    1980-10-09

    The purpose of this program is to provide employees with the motivation, knowledge and skills necessary to maintain ideal body weight throughout life. The target audience for this program, which is conducted in an industrial setting, is the employee 40 years of age or younger who is at or near his/her ideal body weight.

  4. Energy Literacy Essential Principle #7

    SciTech Connect (OSTI)

    2015-03-11

    Energy Literacy Essential Principle #7: The quality of life of individuals and societies is affected by energy choices.

  5. Energy Literacy Essential Principle #2

    SciTech Connect (OSTI)

    2014-12-02

    Energy Literacy Essential Principle #2: Physical processes on Earth are the result of energy flow through the Earth system.

  6. Energy Literacy Essential Principle #6

    SciTech Connect (OSTI)

    2015-03-12

    Energy Literacy Essential Principle #6: The amount of energy used by human society depends on many factors.

  7. Energy Literacy Essential Principle #4

    SciTech Connect (OSTI)

    2014-12-02

    Energy Literacy Essential Principle #4: Various sources of energy can be used to power human activities, and often this energy must be transferred from source to destination.

  8. Peru struggles to maintain crude production

    SciTech Connect (OSTI)

    Not Available

    1991-01-14

    Revival of Peru's moribund oil and gas industry in the 1990s hinges on whether the new administration of President Alberto Fujimori is successful in attracting foreign investment in Peru. Fujimori's success would mean Peru pushing ahead into stepped up exploration and major development projects, such as the huge Camisea gas/condensate field discovered 2 years ago. His failure could mean Peru continuing to fall further behind in its already lagging low oil production. Huge sums of money will be needed. Peru also needs to succeed in its efforts to become creditworthy again for international agencies, foreign governments, and commercial banks. Meanwhile, Petroleos del Peru SA (Petroperu), the state oil company, will have to transfer an increasing share of its operations to private investors. But the company is likely to try to hold onto producing fields, even though it is unable to maintain full output.

  9. Establishing & Maintaining a Strategic Partnership with the Chief...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Establishing & Maintaining a Strategic Partnership with the Chief Financial Officer Establishing & Maintaining a Strategic Partnership with the Chief Financial Officer Neal Elliot ...

  10. Methods for identifying an essential gene in a prokaryotic microorganism

    DOE Patents [OSTI]

    Shizuya, Hiroaki

    2006-01-31

    Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being transformed by artificial means and is capable of undergoing DNA recombination. This system offers an enhanced means of identifying essential function genes in diploid pathogens, such as gram-negative and gram-positive bacteria.

  11. Fibroblasts maintained in 3 dimensions show a better differentiation state and higher sensitivity to estrogens

    SciTech Connect (OSTI)

    Montani, Claudia; Steimberg, Nathalie; Boniotti, Jennifer; Biasiotto, Giorgio; Zanella, Isabella; Diafera, Giuseppe; Biunno, Ida; Caimi, Luigi; Mazzoleni, Giovanna; Di Lorenzo, Diego

    2014-11-01

    Cell differentiation and response to hormonal signals were studied in a 3D environment on an in-house generated mouse fibroblast cell line expressing a reporter gene under the control of estrogen responsive sequences (EREs). 3D cell culture conditions were obtained in a Rotary Cell Culture System; (RCCS™), a microgravity based bioreactor that promotes the aggregation of cells into multicellular spheroids (MCS). In this bioreactor the cells maintained a better differentiated phenotype and more closely resembled in vivo tissue. The RCCS™ cultured fibroblasts showed higher expression of genes regulating cell assembly, differentiation and hormonal functions. Microarray analysis showed that genes related to cell cycle, proliferation, cytoskeleton, migration, adhesion and motility were all down-regulated in 3D as compared to 2D conditions, as well as oncogene expression and inflammatory cytokines. Controlled remodeling of ECM, which is an essential aspect of cell organization, homeostasis and tissue was affected by the culture method as assessed by immunolocalization of β-tubulin. Markers of cell organization, homeostasis and tissue repair, metalloproteinase 2 (MMP2) and its physiological inhibitor (TIMP4) changed expression in association with the relative formation of cell aggregates. The fibroblasts cultured in the RCCS™ maintain a better responsiveness to estrogens, measured as expression of ERα and regulation of an ERE-dependent reporter and of the endogenous target genes CBP, Rarb, MMP1 and Dbp. Our data highlight the interest of this 3D culture model for its potential application in the field of cell response to hormonal signals and the pharmaco-toxicological analyses of chemicals and natural molecules endowed of estrogenic potential. - Highlights: • We here characterized the first cell line derived from an estrogen reporter mouse. • In the RCCS cells express an immortalized behavior but not a transformed phenotype. • The RCCS provides a system for

  12. Maintaining urban gas systems demands special technologies

    SciTech Connect (OSTI)

    Anglero, T.F. )

    1994-04-01

    Brooklyn Union Gas Co. has been providing gas to 50% of the population of New York City for the last 100 years. The company has constructed an elaborate gas distribution network that includes a gas main under nearly every city street in a service territory that includes Brooklyn, Staten Island and parts of Queens. Conventional ways of pipeline construction and maintenance are inadequate in today's environment of heightened competition, increased regulations and, most importantly, demanding customer expectations of quality service. As a result, Brooklyn Union Gas must use special construction and maintenance methods in its operations, and in particular trenchless technologies. Over the past 10 years the company has paid close attention to developing a variety of trenchless techniques. Like many gas distribution companies providing service in densely populated urban areas, Brooklyn Union must operate and maintain its gas distribution network in a challenging environment of increasing governmental regulation and escalating field construction costs. Technological innovation is not a luxury, but instead a necessity to achieve corporate growth, regulatory compliance and greater customer satisfaction. Trenchless technologies offset rising pipe installation costs and provide benefits both to the customer and the company. Of special value to Brooklyn Union is the development of systems that renovate old metal pipes by lining. Such techniques are described.

  13. Heavy Vehicle Essential Power Systems Workshop

    SciTech Connect (OSTI)

    Susan Rogers

    2001-12-12

    Essential power is a crosscutting technology area that addresses the efficient and practical management of electrical and thermal requirements on trucks. Essential Power Systems: any function on the truck, that is not currently involved in moving the truck, and requires electrical or mechanical energy; Truck Lights; Hotel Loads (HVAC, computers, appliances, lighting, entertainment systems); Pumps, starter, compressor, fans, trailer refrigeration; Engine and fuel heating; and Operation of power lifts and pumps for bulk fluid transfer. Transition from ''belt and gear driven'' to auxiliary power generation of electricity - ''Truck Electrification'' 42 volts, DC and/ or AC; All electrically driven auxiliaries; Power on demand - manage electrical loads; Benefits include: increased fuel efficiency, reduced emission both when truck is idling and moving down the road.

  14. Y-12 Construction maintains 'superb' safety performance | Y-12...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Construction maintains ... Y-12 Construction maintains 'superb' safety performance Posted: March 6, 2013 - 6:03pm Tom Morris, B&W Y-12 vice president of projects, presents ...

  15. Establishing & Maintaining a Strategic Partnership with the Chief Financial

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Officer | Department of Energy Establishing & Maintaining a Strategic Partnership with the Chief Financial Officer Establishing & Maintaining a Strategic Partnership with the Chief Financial Officer Neal Elliot of the American Council for an Energy-Efficient Economy shares insights on how to establish and maintain a partnership with the Chief Financial Officer on this presentation. Establishing & Maintaining a Strategic Partnership with the Chief Financial Officer (August 9,

  16. Energy Literacy: Essential Principles and Fundamental Concepts...

    Energy Savers [EERE]

    Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy...

  17. Energy Literacy: Essential Principles and Fundamental Concepts...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy ...

  18. Policy Memorandum #9 - Establishing and Maintaining Competitive Level Codes

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy 9 - Establishing and Maintaining Competitive Level Codes Policy Memorandum #9 - Establishing and Maintaining Competitive Level Codes Policy Memorandum #9 - Establishing and Maintaining Competitive Level Codes.pdf (166.34 KB) More Documents & Publications POLICY GUIDANCE MEMORANDUM #32A Schedule A Appointments of Persons with Disabilities and Appointments for Disabled Veterans POLICY GUIDANCE MEMORANDUM #28 Requirements for Non-Competitive Reassignments into

  19. Recommendation 220: Recommendation Regarding Maintaining Funding for Cleanup

    Broader source: Energy.gov [DOE]

    The Environmental Management Site-Specific Advisory Board recommends that funding for cleanup at DOE sites should be maintained as a top priority.

  20. Operating and Maintaining Your Heat Pump | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Changing filters regularly is an important part of maintaining a heat pump system. | Photo courtesy of iStockphotoBanksPhotos Changing filters regularly is an important part...

  1. Idaho Application for Permit to Construct Modify or Maintain...

    Open Energy Info (EERE)

    Construct Modify or Maintain an Injection Well - Form 42-39-1 Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Idaho...

  2. RRC - Supplemental Application Information for Permit to Maintain...

    Open Energy Info (EERE)

    Supplemental Application Information for Permit to Maintain and Use a Commercial Oil and Gas Waste Disposal Pit Jump to: navigation, search OpenEI Reference LibraryAdd to library...

  3. Y-12 Construction maintains 'superb' safety performance | Y-12 National

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Security Complex Construction maintains ... Y-12 Construction maintains 'superb' safety performance Posted: March 6, 2013 - 6:03pm Tom Morris, B&W Y-12 vice president of projects, presents Construction's safety awards to Monica Lewis, Y-12 craft safety lead representative, and Kevin Adkisson, Knoxville Building and Construction Trades Council president. At a recent celebration, B&W Y-12's Direct-Hire Construction team was honored for two major safety achievements: more than one

  4. Method and apparatus for maintaining equilibrium in a helical axis stellarator

    DOE Patents [OSTI]

    Reiman, A.; Boozer, A.

    1984-10-31

    Apparatus for maintaining three-dimensional MHD equilibrium in a plasma contained in a helical axis stellarator includes a resonant coil system, having a configuration such that current therethrough generates a magnetic field cancelling the resonant magnetic field produced by currents driven by the plasma pressure on any given flux surface resonating with the rotational transform of another flux surface in the plasma. Current through the resonant coil system is adjusted as a function of plasma beta.

  5. Method and apparatus for maintaining equilibrium in a helical axis stellarator

    DOE Patents [OSTI]

    Reiman, Allan; Boozer, Allen

    1987-01-01

    Apparatus for maintaining three-dimensional MHD equilibrium in a plasma contained in a helical axis stellerator includes a resonant coil system, having a configuration such that current therethrough generates a magnetic field cancelling the resonant magnetic field produced by currents driven by the plasma pressure on any given flux surface resonating with the rotational transform of another flux surface in the plasma. Current through the resonant coil system is adjusted as a function of plasma beta.

  6. Proposed EPA Rules Will Cut Carbon Pollution While Maintaining Reliability

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy Proposed EPA Rules Will Cut Carbon Pollution While Maintaining Reliability Proposed EPA Rules Will Cut Carbon Pollution While Maintaining Reliability June 3, 2014 - 4:20pm Addthis Photo via iStock by Getty Images. Photo via iStock by Getty Images. Melanie A. Kenderdine Melanie A. Kenderdine Director of the Office of Energy Policy and Systems Analysis Learn More Watch a video that explains how EPA's Clean Power Plan works. See the projected public health benefits of the

  7. Installing and Maintaining a Small Wind Electric System | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Small Wind Electric System Installing and Maintaining a Small Wind Electric System Installing and Maintaining a Small Wind Electric System If you went through the planning steps to evaluate whether a small wind electric system will work at your location, you will already have a general idea about: The amount of wind at your site The zoning requirements and covenants in your area The economics, payback, and incentives of installing a wind system at your site. Now, it is time to look at

  8. Essential Innovations Technology Corp | Open Energy Information

    Open Energy Info (EERE)

    Technology Corp Jump to: navigation, search Name: Essential Innovations Technology Corp Place: Bellingham,, Washington State Zip: 98225 Sector: Geothermal energy, Services Product:...

  9. Weatherization Guidance on Maintaining Privacy of Recipients of Services

    Broader source: Energy.gov [DOE]

    U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Weatherization Assistance Program Notice 10-08 dealing with requirements of weatherization service providers to maintain the privacy of low-income residents receiving energy efficiency services in their homes.

  10. LED Essentials - Technology, Applications, Advantages, Disadvantages |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Information Resources » Webcasts » LED Essentials - Technology, Applications, Advantages, Disadvantages LED Essentials - Technology, Applications, Advantages, Disadvantages On October 11, 2007, Kevin Dowling, VP of Innovation for Philips Solid-State Lighting Solutions, presented a broad introduction to LED technology, and discussed the technology status, advantages and disadvantages, current applications, future potential, and evolving path of LED technology from

  11. A RAM (Reliability, Availability and Maintainability) analysis of the proposed Tinker AFB Jet Fuel Storage Tank Facility. [Reliability, Availability, and Maintainability

    SciTech Connect (OSTI)

    Wright, R.E.; Sattison, M.B.

    1987-08-01

    The purpose of this study is to determine the Reliability, Availability and Maintainability (RAM) at the 30% design phase of a Jet Fuel Storage Tank Facility that is to be installed at the Tinker Air Force Base, Tulsa, Oklahoma. The Jet Fuel Storage Tank Facility was divided into four subsystems: Fuel Storage and Pipeline Transfer Pumps; Truck Unloading and Loading; Fire Protection (foam and water supply systems); and Electric Power. The RAM analysis was performed on four functions of these subsystems: transferring fuel from the two new 55K barrel storage tanks to the existing fuel pipeline system; transferring fuel from the two 55K barrel storage tanks to the aircraft refueler trucks; transferring fuel from the road transport trucks to the aircraft refueler trucks; and fire protection. A fault tree analysis was performed on each functional system. The quantification was performed for several mission times.

  12. Compact, maintainable 80-KeV neutral beam module

    DOE Patents [OSTI]

    Fink, Joel H.; Molvik, Arthur W.

    1980-01-01

    A compact, maintainable 80-keV arc chamber, extractor module for a neutral beam system immersed in a vacuum of <10.sup.-2 Torr, incorporating a nested 60-keV gradient shield located midway between the high voltage ion source and surrounding grounded frame. The shield reduces breakdown or arcing path length without increasing the voltage gradient, tends to keep electric fields normal to conducting surfaces rather than skewed and reduces the peak electric field around irregularities on the 80-keV electrodes. The arc chamber or ion source is mounted separately from the extractor or ion accelerator to reduce misalignment of the accelerator and to permit separate maintenance to be performed on these systems. The separate mounting of the ion source provides for maintaining same without removing the ion accelerator.

  13. Research Highlight: Virtual Oscillator Control Maintains Grid Operations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with High Inverter Penetrations | Energy Systems Integration | NREL Research Highlight: Virtual Oscillator Control Maintains Grid Operations with High Inverter Penetrations June 21, 2016 Today's power grids rely on massive generators rotating at the correct speed to produce power at a certain frequency: 60 cycles per second in the United States. These generators give inertia to the entire power grid, which enables it to absorb disturbances with minimal deviations in frequency. Under such

  14. Research Highlight: Virtual Oscillator Control Maintains Grid Operations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with High Inverter Penetrations | Grid Modernization | NREL Research Highlight: Virtual Oscillator Control Maintains Grid Operations with High Inverter Penetrations June 21, 2016 Today's power grids rely on massive generators rotating at the correct speed to produce power at a certain frequency: 60 cycles per second in the United States. These generators give inertia to the entire power grid, which enables it to absorb disturbances with minimal deviations in frequency. Under such

  15. Installing and Maintaining a Home Solar Electric System | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Home Solar Electric System Installing and Maintaining a Home Solar Electric System When choosing a contractor, ask about their work record, experience, and licenses, and get more than one bid for the installation of your PV system. | Photo courtesy of Dennis Schroeder, NREL. When choosing a contractor, ask about their work record, experience, and licenses, and get more than one bid for the installation of your PV system. | Photo courtesy of Dennis Schroeder, NREL. Making sure your

  16. Energy Literacy: Essential Principle #1 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1 Energy Literacy: Essential Principle #1 Addthis Essential Principle #1 - Energy is a physical quantity that follows precise natural laws

  17. Energy Literacy: Essential Principle #3 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    3 Energy Literacy: Essential Principle #3 Addthis Essential Principle #3 - Biological processes depend on energy flow through

  18. Oscillatory nonhmic current drive for maintaining a plasma current

    DOE Patents [OSTI]

    Fisch, Nathaniel J.

    1986-01-01

    Apparatus and method of the invention maintain a plasma current with an oscillatory nonohmic current drive. Each cycle of operation has a generation period in which current driving energy is applied to the plasma, and a relaxation period in which current driving energy is removed. Plasma parameters, such as plasma temperature or plasma average ionic charge state, are modified during the generation period so as to oscillate plasma resistivity in synchronism with the application of current driving energy. The invention improves overall current drive efficiencies.

  19. Oscillatory nonohomic current drive for maintaining a plasma current

    DOE Patents [OSTI]

    Fisch, N.J.

    1984-01-01

    Apparatus and methods are described for maintaining a plasma current with an oscillatory nonohmic current drive. Each cycle of operation has a generation period in which current driving energy is applied to the plasma, and a relaxation period in which current driving energy is removed. Plasma parameters, such as plasma temperature or plasma average ionic charge state, are modified during the generation period so as to oscillate plasma resistivity in synchronism with the application of current driving energy. The invention improves overall current drive efficiencies.

  20. Application of systems engineering techniques (reliability, availability, maintainability, and dollars) to the Gas Centrifuge Enrichment Plant

    SciTech Connect (OSTI)

    Boylan, J.G.; DeLozier, R.C.

    1982-01-01

    The systems engineering function for the Gas Centrifuge Enrichment Plant (GCEP) covers system requirements definition, analyses, verification, technical reviews, and other system efforts necessary to assure good balance of performance, safety, cost, and scheduling. The systems engineering function will support the design, installation, start-up, and operational phases of GCEP. The principal objectives of the systems engineering function are to: assure that the system requirements of the GCEP process are adequately specified and documented and that due consideration and emphasis are given to all aspects of the project; provide system analyses of the designs as they progress to assure that system requirements are met and that GCEP interfaces are compatible; assist in the definition of programs for the necessary and sufficient verification of GCEP systems; and integrate reliability, maintainability, logistics, safety, producibility, and other related specialties into a total system effort. This paper addresses the GCEP reliability, availability, maintainability, and dollars (RAM dollars) analyses which are the primary systems engineering tools for the development and implementation of trade-off studies. These studies are basic to reaching cost-effective project decisions. The steps necessary to achieve optimum cost-effective design are shown.

  1. Guide to Operating and Maintaining EnergySmart Schools

    SciTech Connect (OSTI)

    2010-01-01

    Through a commitment to high performance, school districts are discovering that smart energy choices can create lasting benefits for students, communities, and the environment. For example, an energy efficient school district with 4,000 students can save as much as $160,000 a year in energy costs. Over 10 years, those savings can reach $1.6 million, translating into the ability to hire more teachers, purchase more textbooks and computers, or invest in additional high performance facilities. Beyond these bottomline benefits, schools can better foster student health, decrease absenteeism, and serve as centers of community life. The U.S. Department of Energy's EnergySmart Schools Program promotes a 30 percent improvement in existing school energy use. It also encourages the building of new schools that exceed code (ASHRAE 90.11999) by 50 percent or more. The program provides resources like this Guide to Operating and Maintaining EnergySmart Schools to assist school decisionmakers in planning, financing, operating, and maintaining energy efficient, high performance schools. It also offers education and training for building industry professionals. Operations and maintenance refer to all scheduled and unscheduled actions for preventing equipment failure or decline with the goal of increasing efficiency, reliability, and safety. A preventative maintenance program is the organized and planned performance of maintenance activities in order to prevent system or production problems or failures from occurring. In contrast, deferred maintenance or reactive maintenance (also called diagnostic or corrective maintenance) is conducted to address an existing problem. This guide is a primary resource for developing and implementing a districtor schoolwide operations and maintenance (O&M) program that focuses on energy efficiency. The EnergySmart Schools Solutions companion CD contains additional supporting information for design, renovation, and retrofit projects. The objective of

  2. Study on eliminating fire dampers to maintain process confinement

    SciTech Connect (OSTI)

    Walling, R.C.; Patel, J.B.; Strunk, A.J.

    1991-12-31

    The DOE General Design Criteria for the Defense Waste Processing Facility (DWPF) at the Westinghouse Savannah River Site (WSRS) requires the NFPA National Fire Codes to be incorporated into the design and simultaneously maintain process confinement integrity to prevent the release of radioactivity. Although the NFPA Standard for the Installation of Air Conditioning and Ventilation Systems, NFPA 90, requires fire dampers (FD) in HVAC duct penetrations of two hour rated fire barriers, closure of fire dampers at DWPF may compromise the integrity of the process confinement system. This leads to the need for an overall risk assessment to determine the value of 39 fire dampers that are identified later in the study as capable of a confinement system upset.

  3. Study on eliminating fire dampers to maintain process confinement

    SciTech Connect (OSTI)

    Walling, R.C.; Patel, J.B.; Strunk, A.J.

    1991-01-01

    The DOE General Design Criteria for the Defense Waste Processing Facility (DWPF) at the Westinghouse Savannah River Site (WSRS) requires the NFPA National Fire Codes to be incorporated into the design and simultaneously maintain process confinement integrity to prevent the release of radioactivity. Although the NFPA Standard for the Installation of Air Conditioning and Ventilation Systems, NFPA 90, requires fire dampers (FD) in HVAC duct penetrations of two hour rated fire barriers, closure of fire dampers at DWPF may compromise the integrity of the process confinement system. This leads to the need for an overall risk assessment to determine the value of 39 fire dampers that are identified later in the study as capable of a confinement system upset.

  4. Ecuador to withdraw from OPEC; group to maintain present flow

    SciTech Connect (OSTI)

    Not Available

    1992-09-28

    This paper reports that the Organization of Petroleum Exporting Countries, which has agreed to maintain its present combined production of 24.2 million b/d of oil in the fourth quarter, will soon see the first pullout of a member. The 13 member group will shrink to 12, probably in November, when Ecuador withdraws. Ecuador President Sixto Duran Ballen issued notice of the pullout Sept. 17, a little more than 1 month after he took office. Ecuador, strapped for cash, wants to save OPEC membership dues reported to be $2-3 million/year. It plans to remain an associate member, although it wasn't immediately clear what that means. No other countries are regarded as associate members.

  5. Reliability and Maintainability Data for Liquid Metal Cooling Systems

    SciTech Connect (OSTI)

    Cadwallader, Lee Charles

    2015-05-01

    One of the coolants of interest for future fusion breeding blankets is lead-lithium. As a liquid metal it offers the advantages of high temperature operation for good station efficiency, low pressure, and moderate flow rate. This coolant is also under examination for use in test blanket modules to be used in the ITER international project. To perform reliability, availability, maintainability and inspectability (RAMI) assessment as well as probabilistic safety assessment (PSA) of lead-lithium cooling systems, component failure rate data are needed to quantify the system models. RAMI assessment also requires repair time data and inspection time data. This paper presents a new survey of the data sets that are available at present to support RAMI and PSA quantification. Recommendations are given for the best data values to use when quantifying system models.

  6. Can Canister Containment Be Maintained After Accidental Drop Events?

    SciTech Connect (OSTI)

    D. K. Morton; S. D. Snow; T. E. Rahl; R. K. Blandford; T. J. Hill

    2006-05-01

    The National Spent Nuclear Fuel Program (NSNFP) has pursued a number of structural testing projects that are intended to provide data that can be used to substantiate the position that U. S. Department of Energy (DOE) spent nuclear fuel (SNF) canisters, made from austenitic stainless steels, can maintain containment after an accidental drop event and that plastic finite element methods can be used to accurately predict the structural response of canister configurations not specifically tested. In particular, drop tests of full-scale canisters and material impact testing at varying strain rates reflecting accidental drop conditions have been completed or are in progress. This paper provides insights to conclusions achieved to date and what efforts are planned to fully address the pertinent issues necessary to demonstrate the safety of DOE SNF canisters subjected to accidental drop events.

  7. Virtual Oscillator Control Maintains Grid Operations with High...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Result VOC has been demonstrated in a microgrid using several small inverters. In ... NREL has demonstrated VOC on a small microgrid, but to make sure VOC would function ...

  8. World tanker industry maintains momentum from Persian Gulf war

    SciTech Connect (OSTI)

    Not Available

    1991-06-10

    The world tanker industry has managed to maintain the momentum generated during the Persian Gulf War. Freight rates for large vessels have regained the high levels seen during the first 2 months of this year, while the expected postwar decline in use of tankers has not materialized. The health of the tanker industry is linked closely with the volume of long haul crude oil from the Middle East, a spot charter from the gulf to Europe, an owner would only break even on the cost of building and operating a new tanker to the highest environmental standards. Owners currently can expect spot rates of about $40,000/day, excellent by the standards of the late 1980s and early 1990s but still below the level needed to justify new buildings. And there are many in the industry who think $40,000/day will be just a happy memory later in the year. Owners are facing pressure for major changes in the industry. Governments and the public want better operating standards and new environmentally sound tankers to reduce the risk of oil spills. At the same time, the industry has to learn to live with repercussion in the 1990 Oil Pollution Act in the U.S., which has opened the way for unlimited liability against tanker owners involved in spills off the U.S. The search also is on for improved profits to make investments required by the changing world of seaborne oil transportation.

  9. Energizing the "K-Gray" Community: Energy Literacy Essential...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energizing the "K-Gray" Community: Energy Literacy Essential Principles and Fundamental Concepts Energizing the "K-Gray" Community: Energy Literacy Essential Principles and ...

  10. Energy Literacy: Essential Principle #2 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 Energy Literacy: Essential Principle #2 Addthis Essential Principle #2 - Physical processes on Earth are the result of energy flow through

  11. Energy Assurance: Essential Energy Technologies for Climate Protection...

    Office of Scientific and Technical Information (OSTI)

    Energy Assurance: Essential Energy Technologies for Climate Protection and Energy Security Citation Details In-Document Search Title: Energy Assurance: Essential Energy ...

  12. Text-Alternative Version: LED Essentials- Technology, Applications, Advantages, Disadvantages

    Broader source: Energy.gov [DOE]

    Below is the text-alternative version of the LED Essentials - Technology, Applications, Advantages, Disadvantages webcast.

  13. Method for maintaining a cutting blade centered in a kerf

    DOE Patents [OSTI]

    Blaedel, Kenneth L.; Davis, Pete J.; Landram, Charles S.

    2002-01-01

    A saw having a self-pumped hydrodynamic blade guide or bearing for retaining the saw blade in a centered position in the saw kerf (width of cut made by the saw). The hydrodynamic blade guide or bearing utilizes pockets or grooves incorporated into the sides of the blade. The saw kerf in the workpiece provides the guide or bearing stator surface. Both sides of the blade entrain cutting fluid as the blade enters the kerf in the workpiece, and the trapped fluid provides pressure between the blade and the workpiece as an inverse function of the gap between the blade surface and the workpiece surface. If the blade wanders from the center of the kerf, then one gap will increase and one gap will decrease and the consequent pressure difference between the two sides of the blade will cause the blade to re-center itself in the kerf. Saws using the hydrodynamic blade guide or bearing have particular application in slicing slabs from boules of single crystal materials, for example, as well as for cutting other difficult to saw materials such as ceramics, glass, and brittle composite materials.

  14. PHMC Year 2000: Status reporting for mission essential Year 2000 projects. Revision 0, Volume 3

    SciTech Connect (OSTI)

    Layfield, K.A.

    1998-09-02

    The PHMC Year 2000 status reporting process is designed to encompass the reporting requirements of the Office of Management and Budget (OMB), DOE HQ, RL and the PHMC for mission essential Year 2000 projects. Status reporting is required for all Year 2000 projects. The Year 2000 project list will be maintained current as Year 2000 projects are modified, added or deleted. Reporting is required until a Year 2000 project has completed compliance assurance. Some projects will be identified as DOE HQ reportable. These are projects determined to be the most critical and due the attention of DOE HQ.

  15. Energy Literacy: Essential Principle #4 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    4 Energy Literacy: Essential Principle #4 Addthis Essential Principle #4 - Various sources of energy can be used to power human activities, and often this energy must be transferred from source to destination

  16. Essential Body of Knowledge (EBK) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Services » Training » Cybersecurity Training Warehouse » DOE Training & Education » Essential Body of Knowledge (EBK) Essential Body of Knowledge (EBK) Train12.jpg The OCIO has developed a DOE-specific Essential Body of Knowledge (EBK) using DOE cybersecurity policy, industry best practices and lessons learned, and comprehensive internal needs assessments to identify fundamental cybersecurity roles and associated responsibilities. Core competencies, as identified and documented in the

  17. Interim Stabilization Equipment Essential and Support Drawing Plan

    SciTech Connect (OSTI)

    KOCH, M.R.

    1999-10-22

    The purpose of this document is to list the Interim Stabilization equipment drawings that are classified as Essential or Support drawings. Essential Drawings: Those drawings identified by the facility staff as necessary to directly support the safe operation of the facility or equipment. Support Drawings: Those drawings identified by the facility staff that further describe the design details of structures, systems or components shown on essential drawings.

  18. Energy Literacy: Essential Principles and Fundamental Concepts for Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Education | Department of Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education News and Updates Check out our new Energy Literacy video series! The Energy Literacy Framework is also available in Spanish: Conocimiento de Energía. What is Energy Literacy? Energy Literacy is an understanding of the

  19. Energy Literacy Social Studies Guide - Essential Principle 4...

    Broader source: Energy.gov (indexed) [DOE]

    Summary Discussion points related to Essential Principle 4: Various sources of energy can be used to power human activities, and often this energy must be transferred from source ...

  20. Essential Body of Knowledge (EBK) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Documents & Publications Essential Body of Knowledge (EBK) DOE CYBER SECURITY EBK: CORE COMPETENCY TRAINING REQUIREMENTS: CA DOE CYBER SECURITY EBK: MINIMUM CORE COMPETENCY ...

  1. Energy Literacy Social Studies Guide - Essential Principle 3...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Summary Discussion points related to Essential Principle 3: Biological processes depend on energy flow through the Earth system. Curriculum Social Studies Time Required 3-4 class ...

  2. Energy Literacy Social Studies Guide - Essential Principle 2...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Summary Discussion points related to Essential Principle 2: Physical processes on Earth are the result of energy flow through the Earth system. Curriculum Social Studies Time ...

  3. Essential Innovations Ekistics Town Planning Jiangsu Sifang Culture...

    Open Energy Info (EERE)

    Geothermal energy Product: Announced in October 2006, this is a JV between Essential Innovation of Canada, Ekistics Town Planning also of Canada, and Jiangsu Sifang Culture...

  4. Energy Literacy Social Studies Guide - Essential Principle 7...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    impact the environment? Summary Discussion points related to Essential Principle 7: The quality of life of individuals and societies is affected by energy choices. Curriculum...

  5. On the analysis and comparison of conformer-specific essential...

    Office of Scientific and Technical Information (OSTI)

    Essential dynamics subspaces associated to conformational transitions can also be analyzed. As a test case, we study the glutaminase interacting protein (GIP), composed of a single ...

  6. Energy Literacy Social Studies Guide - Essential Principle 5...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    5 Energy Literacy Social Studies Guide - Essential Principle 5 Below is information about ... Energy decisions are influenced by economic, political, environmental, and social factors. ...

  7. Energy Literacy Social Studies Guide - Essential Principle 1...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1 Energy Literacy Social Studies Guide - Essential Principle 1 Below is information about ... follows precise natural laws. Curriculum Social Studies Time Required 3-4 class periods ...

  8. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kiser, Philip D.; Zhang, Jianye; Badiee, Mohsen; Li, Qingjiang; Shi, Wuxian; Sui, Xuewu; Golczak, Marcin; Tochtrop, Gregory P.; Palczewski, Krzysztof

    2015-04-20

    Visual function in vertebrates is dependent on the membrane-bound retinoid isomerase RPE65, an essential component of the retinoid cycle pathway that regenerates 11-cis-retinal for rod and cone opsins. The mechanism by which RPE65 catalyzes stereoselective retinoid isomerization has remained elusive because of uncertainty about how retinoids bind to its active site. Here we present crystal structures of RPE65 in complex with retinoid-mimetic compounds, one of which is in clinical trials for the treatment of age-related macular degeneration. The structures reveal the active site retinoid-binding cavity located near the membrane-interacting surface of the enzyme as well as an Fe-bound palmitate ligandmore » positioned in an adjacent pocket. With the geometry of the RPE65–substrate complex clarified, we delineate a mechanism of catalysis that reconciles the extensive biochemical and structural research on this enzyme. Finally, these data provide molecular foundations for understanding a key process in vision and pharmacological inhibition of RPE65 with small molecules.« less

  9. Wave-function functionals

    SciTech Connect (OSTI)

    Pan Xiaoyin; Slamet, Marlina; Sahni, Viraht

    2010-04-15

    We extend our prior work on the construction of variational wave functions {psi} that are functionals of functions {chi}:{psi}={psi}[{chi}] rather than simply being functions. In this manner, the space of variations is expanded over those of traditional variational wave functions. In this article we perform the constrained search over the functions {chi} chosen such that the functional {psi}[{chi}] satisfies simultaneously the constraints of normalization and the exact expectation value of an arbitrary single- or two-particle Hermitian operator, while also leading to a rigorous upper bound to the energy. As such the wave function functional is accurate not only in the region of space in which the principal contributions to the energy arise but also in the other region of the space represented by the Hermitian operator. To demonstrate the efficacy of these ideas, we apply such a constrained search to the ground state of the negative ion of atomic hydrogen H{sup -}, the helium atom He, and its positive ions Li{sup +} and Be{sup 2+}. The operators W whose expectations are obtained exactly are the sum of the single-particle operators W={Sigma}{sub i}r{sub i}{sup n},n=-2,-1,1,2, W={Sigma}{sub i{delta}}(r{sub i}), W=-(1/2){Sigma}{sub i{nabla}i}{sup 2}, and the two-particle operators W={Sigma}{sub n}u{sup n},n=-2,-1,1,2, where u=|r{sub i}-r{sub j}|. Comparisons with the method of Lagrangian multipliers and of other constructions of wave-function functionals are made. Finally, we present further insights into the construction of wave-function functionals by studying a previously proposed construction of functionals {psi}[{chi}] that lead to the exact expectation of arbitrary Hermitian operators. We discover that analogous to the solutions of the Schroedinger equation, there exist {psi}[{chi}] that are unphysical in that they lead to singular values for the expectations. We also explain the origin of the singularity.

  10. DOE-TSPP-7-2013, Maintaining DOE Technical Standards | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7-2013, Maintaining DOE Technical Standards DOE-TSPP-7-2013, Maintaining DOE Technical Standards Technical Standards Program Procedures (TSPP) - September 16, 2013 This Procedure provides guidance for the routine maintenance of the Department of Energy (DOE) Technical Standards. This Procedure applies to all DOE Headquarters and field organizations, management and operating contractors, and laboratories (hereafter referred to collectively as Technical Standards Program (TSP) participants)

  11. Maintaining molten salt electrolyte concentration in aluminum-producing electrolytic cell

    DOE Patents [OSTI]

    Barnett, Robert J.; Mezner, Michael B.; Bradford, Donald R

    2005-01-04

    A method of maintaining molten salt concentration in a low temperature electrolytic cell used for production of aluminum from alumina dissolved in a molten salt electrolyte contained in a cell free of frozen crust wherein volatile material is vented from the cell and contacted and captured on alumina being added to the cell. The captured volatile material is returned with alumina to cell to maintain the concentration of the molten salt.

  12. Remote sensing-based characterization of plant functional type...

    Office of Scientific and Technical Information (OSTI)

    Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral...

  13. Remote sensing-based characterization of plant functional type

    Office of Scientific and Technical Information (OSTI)

    Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral...

  14. Energy Literacy Social Studies Guide - Essential Principle 6...

    Broader source: Energy.gov (indexed) [DOE]

    Summary Discussion points related to Essential Principle 6: The amount of energy used by human society depends on many factors. Curriculum Social Studies Time Required 3-4 class ...

  15. The Need for Essential Consumer Protections: Smart metering proposals...

    Energy Savers [EERE]

    August 2010 The Need for Essential Consumer Protections: Smart metering proposals and the move to time-based pricing. August 2010 There is widespread consensus that the U.S. ...

  16. The Need for Essential Consumer Protections: Smart Metering Proposals...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Metering Proposals and the Move to Time-Based Pricing The Need for Essential Consumer Protections: Smart Metering Proposals and the Move to Time-Based Pricing There is a widespread ...

  17. Energy Literacy Social Studies Guide – Essential Principle 7

    K-12 Energy Lesson Plans and Activities Web site (EERE)

    A guide for social studies educators using the Energy Literacy framework and videos. Includes discussion points related to Essential Principle 7: "The quality of life of individuals and societies is affected by energy choices."

  18. Combined Heat and Power (CHP): Essential for a Cost Effective...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for a Cost Effective Clean Energy Standard, April 2011 Combined Heat and Power (CHP): Essential for a Cost Effective Clean Energy Standard, April 2011 In March 2011, a federal ...

  19. Energy Literacy Social Studies Guide – Essential Principle 6

    K-12 Energy Lesson Plans and Activities Web site (EERE)

    A guide for social studies educators using the Energy Literacy framework and videos. Includes discussion points related to Essential Principle 6: "The amount of energy used by human society depends on many factors."

  20. Energy Literacy Social Studies Guide - Essential Principle 2 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 2 Energy Literacy Social Studies Guide - Essential Principle 2 Below is information about the student activity/lesson plan from your search. Grades 9-12 Subject How has water shaped human settlement? Summary Discussion points related to Essential Principle 2: Physical processes on Earth are the result of energy flow through the Earth system. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson Plans/Activity

  1. Energy Literacy Social Studies Guide - Essential Principle 5 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 5 Energy Literacy Social Studies Guide - Essential Principle 5 Below is information about the student activity/lesson plan from your search. Grades 9-12 Subject Should the U.S. Government subsidize specific energy initiatives? Summary Discussion points related to Essential Principle 5: Energy decisions are influenced by economic, political, environmental, and social factors. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson

  2. Energy Department Helps Rhode Island Schools Teach Energy Essentials |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Rhode Island Schools Teach Energy Essentials Energy Department Helps Rhode Island Schools Teach Energy Essentials September 21, 2015 - 4:17pm Addthis Students participating in the NEED Project at Scituate High and Calcutt Middle Schools planted 14 trees in Central Falls, Rhode Island. Students participating in the NEED Project at Scituate High and Calcutt Middle Schools planted 14 trees in Central Falls, Rhode Island. Calcutt Middle School students in Rhode Island played

  3. EERE Success Story-Rhode Island Schools Teach Energy Essentials |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Rhode Island Schools Teach Energy Essentials EERE Success Story-Rhode Island Schools Teach Energy Essentials December 10, 2015 - 11:24am Addthis Students participating in the NEED Project at Scituate High and Calcutt Middle Schools planted 14 trees in Central Falls, Rhode Island. Photo Courtesy | Rhode Island Public Schools Students participating in the NEED Project at Scituate High and Calcutt Middle Schools planted 14 trees in Central Falls, Rhode Island. Photo

  4. Wide Bandgap Semiconductors: Essential to Our Technology Future |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Wide Bandgap Semiconductors: Essential to Our Technology Future Wide Bandgap Semiconductors: Essential to Our Technology Future January 15, 2014 - 8:00am Addthis Learn how wide bandgap semiconductors could impact clean energy technology and our daily lives. | Video by Sarah Gerrity and Matty Greene, Energy Department. Dr. Ernest Moniz Dr. Ernest Moniz Secretary of Energy What are the key facts? North Carolina State University will lead the Energy Department's new

  5. Recommendations to the NRC on human engineering guidelines for nuclear power plant maintainability

    SciTech Connect (OSTI)

    Badalamente, R.V.; Fecht, B.A.; Blahnik, D.E.; Eklund, J.D.; Hartley, C.S.

    1986-03-01

    This document contains human engineering guidelines which can enhance the maintainability of nuclear power plants. The guidelines have been derived from general human engineering design principles, criteria, and data. The guidelines may be applied to existing plants as well as to plants under construction. They apply to nuclear power plant systems, equipment and facilities, as well as to maintenance tools and equipment. The guidelines are grouped into seven categories: accessibility and workspace, physical environment, loads and forces, maintenance facilities, maintenance tools and equipment, operating equipment design, and information needs. Each chapter of the document details specific maintainability problems encountered at nuclear power plants, the safety impact of these problems, and the specific maintainability design guidelines whose application can serve to avoid these problems in new or existing plants.

  6. Systems and methods for maintaining multiple objects within a camera field-of-view

    DOE Patents [OSTI]

    Gans, Nicholas R.; Dixon, Warren

    2016-03-15

    In one embodiment, a system and method for maintaining objects within a camera field of view include identifying constraints to be enforced, each constraint relating to an attribute of the viewed objects, identifying a priority rank for the constraints such that more important constraints have a higher priority that less important constraints, and determining the set of solutions that satisfy the constraints relative to the order of their priority rank such that solutions that satisfy lower ranking constraints are only considered viable if they also satisfy any higher ranking constraints, each solution providing an indication as to how to control the camera to maintain the objects within the camera field of view.

  7. Thermal element for maintaining minimum lamp wall temperature in fluorescent fixtures

    DOE Patents [OSTI]

    Siminovitch, Michael J.

    1992-01-01

    In a lighting fixture including a lamp and a housing, an improvement is disclosed for maintaining a lamp envelope area at a cooler, reduced temperature relative to the enclosed housing ambient. The improvement comprises a thermal element in thermal communication with the housing extending to and springably urging thermal communication with a predetermined area of the lamp envelope surface.

  8. Thermal element for maintaining minimum lamp wall temperature in fluorescent fixtures

    DOE Patents [OSTI]

    Siminovitch, M.J.

    1992-11-10

    In a lighting fixture including a lamp and a housing, an improvement is disclosed for maintaining a lamp envelope area at a cooler, reduced temperature relative to the enclosed housing ambient. The improvement comprises a thermal element in thermal communication with the housing extending to and springably urging thermal communication with a predetermined area of the lamp envelope surface. 12 figs.

  9. Method and apparatus for maintaining the pH in zinc-bromine battery systems

    DOE Patents [OSTI]

    Grimes, Patrick G.

    1985-09-10

    A method and apparatus for maintaining the pH level in a zinc-bromine battery features reacting decomposition hydrogen with bromine in the presence of a catalyst. The catalyst encourages the formation of hydrogen and bromine ions. The decomposition hydrogen is therefore consumed, alloying the pH of the system to remain substantially at a given value.

  10. EM Completes Project to Maintain Water Quality of Spent Nuclear Fuel Basin at Idaho Site

    Broader source: Energy.gov [DOE]

    IDAHO FALLS, Idaho – EM and its main cleanup contractor at DOE’s Idaho Site recently reached a major project milestone necessary to maintain water quality and continued, safe operations within the site’s spent nuclear fuel storage basin.

  11. Healthy and Affordable Housing: Practical Recommendations for Building, Renovating and Maintaining Housing: Read This Before You Move In

    SciTech Connect (OSTI)

    2001-09-06

    This document provides advice for healthy and affordable housing: practical recommendations for building, renovating, and maintaining housing.

  12. Reduced expression of Autographa californica nucleopolyhedrovirus ORF34, an essential gene, enhances heterologous gene expression

    SciTech Connect (OSTI)

    Salem, Tamer Z.; Department of Microbial Molecular Biology, AGERI, Agricultural Research Center, Giza 12619; Division of Biomedical Sciences, Zewail University, Zewail City of Science and Technology, Giza 12588 ; Zhang, Fengrui; Thiem, Suzanne M.

    2013-01-20

    Autographa californica multiple nucleopolyhedrovirus ORF34 is part of a transcriptional unit that includes ORF32, encoding a viral fibroblast growth factor (FGF) and ORF33. We identified ORF34 as a candidate for deletion to improve protein expression in the baculovirus expression system based on enhanced reporter gene expression in an RNAi screen of virus genes. However, ORF34 was shown to be an essential gene. To explore ORF34 function, deletion (KO34) and rescue bacmids were constructed and characterized. Infection did not spread from primary KO34 transfected cells and supernatants from KO34 transfected cells could not infect fresh Sf21 cells whereas the supernatant from the rescue bacmids transfection could recover the infection. In addition, budded viruses were not observed in KO34 transfected cells by electron microscopy, nor were viral proteins detected from the transfection supernatants by western blots. These demonstrate that ORF34 is an essential gene with a possible role in infectious virus production.

  13. Energy Literacy Social Studies Guide - Essential Principle 3 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 3 Energy Literacy Social Studies Guide - Essential Principle 3 Below is information about the student activity/lesson plan from your search. Grades 9-12 Subject Where does our food come from? Summary Discussion points related to Essential Principle 3: Biological processes depend on energy flow through the Earth system. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson Plans/Activity EL3_SocStudiesGuides_AGI.pdf (113.67 KB) More

  14. Energy Literacy Social Studies Guide - Essential Principle 1 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 1 Energy Literacy Social Studies Guide - Essential Principle 1 Below is information about the student activity/lesson plan from your search. Grades 9-12 Subject How should the United States deal with nuclear waste? Summary Discussion points related to Essential Principle 1: Energy is a physical quantity that follows precise natural laws. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson Plans/Activity EL1_SocStudiesGuides_AGI.pdf

  15. Methods and devices for maintaining a resonant wavelength of a photonic microresonator

    DOE Patents [OSTI]

    Jones, Adam; Zortman, William A.

    2015-07-14

    A photonic microresonator incorporates a localized heater element within a section of an optical bus waveguide that is in proximity to the resonator structure. The application of an adjustable control voltage to the heater element provides a localized change in the refractive index value of the bus waveguide, compensating for temperature-induced wavelength drift and maintaining a stabilized value of the microresonator's resonant wavelength.

  16. Energy Literacy Social Studies Guide – Essential Principle 4

    K-12 Energy Lesson Plans and Activities Web site (EERE)

    A guide for social studies educators using the Energy Literacy framework and videos. Includes discussion points related to Essential Principle 4: "Various sources of energy can be used to power human activities, and often this energy must be transferred from source to destination."

  17. Apparatus and method for maintaining low temperatures about an object at a remote location

    DOE Patents [OSTI]

    Steyert, Jr., William A.; Overton, Jr., William C.

    1982-01-01

    The disclosure is directed to an apparatus and method for maintaining a body at cryogenic temperatures at a remote location such as down a borehole for an extended period of time. A housing contains a body comprising a material having a high specific heat at cryogenic temperatures such as between about 2 and 15 K. The body contains an orifice for containing an instrument or instruments operable at superconducting temperatures. The apparatus is precooled at the surface and lowered into a borehole to a desired depth, such as 2 to 3 miles. The instruments are operated, and the apparatus withdrawn, the material of the body maintaining the very low temperatures at which the instrument(s) operate for a sufficient period of time at the remote or downhole location. The material may comprise a rare earth compound, such as Gd.sub.2 O.sub.3, Gd.sub.2 Se.sub.3, Gd.sub.2 O.sub.2 S or GdAlO.sub.3. Monoclinic and C-phase gadolinium oxides work well. A low temperature is maintainable at a remote location for several hours.

  18. Apparatus and method for maintaining low temperatures about an object at a remote location. [Patent application

    DOE Patents [OSTI]

    Steyert, W.A. Jr.; Overton, W.C. Jr.

    1980-10-29

    The disclosure is directed to an apparatus and method for maintaining a body at cryogenic temperatures at a remote location such as down a borehole for an extended period of time. A housing contains a body comprising a material having a high specific heat at cryogenic temperatures such as between about 2 and 15 K. The body contains an orifice for containing an instrument or instruments operable at superconducting temperatures. The apparatus is precooled at the surface and lowered into a borehole to a desired depth, such as 2 to 3 miles. The instruments are operated, and the apparatus withdrawn, the material of the body maintaining the very low temperatures at which the instrument(s) operate for a sufficient period of time at the remote or downhole location. The material may comprise a rare earth compound, such as Gd/sub 2/O/sub 3/, Gd/sub 2/Se/sub 3/, Gd/sub 2/O/sub 2/S or GdAlO/sub 3/. Monoclinic and C-phase gadolinium oxides work well. A low temperature is maintainable at a remote location for several hours.

  19. Long-Term Surveillance and Maintenance Records: Maintaining Access to the Knowledge - 13122

    SciTech Connect (OSTI)

    Montgomery, John; Gueretta, Jeanie; McKinney, Ruth; Anglim, Cliff

    2013-07-01

    The U.S. Department of Energy (DOE) Office of Legacy Management (LM) is an integral part of DOE's strategy to ensure that legacy liabilities of former nuclear weapons production sites are properly managed following the completion of environmental cleanup activities. In the area of environmental legacy management, records management is crucial to the protection of health, environmental, and legal interests of the Department and the public. LM is responsible for maintaining long-term surveillance and maintenance (LTS and M) records in performance of its mission. Maintaining access to the knowledge contained in these record collections is one of LM's primary responsibilities. To fulfill this responsibility, LM established a consolidated records management facility, the LM Business Center (LMBC), to house physical media records and electronic records. A new electronic record keeping system (ERKS) was needed to replace an obsolete system while helping to ensure LM is able to meet ongoing responsibilities to maintain access to knowledge and control the life cycle management of records. (authors)

  20. Functional nucleic acid probes and uses thereof

    DOE Patents [OSTI]

    Nilsen-Hamilton, Marit

    2006-10-03

    The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least one functional nucleic acid, at least one regulating nucleic acid, and at least one attenuator. The functional nucleic acid is maintained in an inactive state by the attenuator and activated by the regulating nucleic acid only in the presence of a regulating nucleic acid target. In its activated state the functional nucleic acid can bind to its target to carry out a desired function, such as generating a signal, cleaving a nucleic acid, or catalyzing a reaction.

  1. The reticulons: Guardians of the structure and function of the endoplasmic reticulum

    SciTech Connect (OSTI)

    Di Sano, Federica; Bernardoni, Paolo; Piacentini, Mauro; National Institute for Infectious Diseases, IRCCS 'L. Spallanzani', Via Portuense, 00149 Rome

    2012-07-01

    The endoplasmic reticulum (ER) consists of the nuclear envelope and a peripheral network of tubules and membrane sheets. The tubules are shaped by a specific class of curvature stabilizing proteins, the reticulons and DP1; however it is still unclear how the sheets are assembled. The ER is the cellular compartment responsible for secretory and membrane protein synthesis. The reducing conditions of ER lead to the intra/inter-chain formation of new disulphide bonds into polypeptides during protein folding assessed by enzymatic or spontaneous reactions. Moreover, ER represents the main intracellular calcium storage site and it plays an important role in calcium signaling that impacts many cellular processes. Accordingly, the maintenance of ER function represents an essential condition for the cell, and ER morphology constitutes an important prerogative of it. Furthermore, it is well known that ER undergoes prominent shape transitions during events such as cell division and differentiation. Thus, maintaining the correct ER structure is an essential feature for cellular physiology. Now, it is known that proper ER-associated proteins play a fundamental role in ER tubules formation. Among these ER-shaping proteins are the reticulons (RTN), which are acquiring a relevant position. In fact, beyond the structural role of reticulons, in very recent years new and deeper functional implications of these proteins are emerging in relation to their involvement in several cellular processes.

  2. The Need for Essential Consumer Protections: Smart Metering Proposals and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Move to Time-Based Pricing | Department of Energy Metering Proposals and the Move to Time-Based Pricing The Need for Essential Consumer Protections: Smart Metering Proposals and the Move to Time-Based Pricing There is a widespread consensus that the U.S. distribution and transmission systems for vital electricity service need to be modernized and upgraded to handle not only load growth, but the integration of renewable resources and the potential for a significant increase in

  3. Location of the essential spectrum in curved quantum layers

    SciTech Connect (OSTI)

    Krejčiřík, David; Lu, Zhiqin

    2014-08-15

    We consider the Dirichlet Laplacian in tubular neighbourhoods of complete non-compact Riemannian manifolds immersed in the Euclidean space. We show that the essential spectrum coincides with the spectrum of a planar tube provided that the second fundamental form of the manifold vanishes at infinity and the transport of the cross-section along the manifold is asymptotically parallel. For low dimensions and codimension, the result applies to the location of propagating states in nanostructures under physically natural conditions.

  4. Hanford Site guide for preparing and maintaining generator group pollution prevention program documentation

    SciTech Connect (OSTI)

    PLACE, B.G.

    1998-11-16

    This document provides guidance to generator groups for preparing and maintaining documentation of Pollution Prevention Waste Minimization (P2/WMin) Program activities. The guidance is one of a hierarchical series that includes the Hanford Site Waste Minimization and Pollution Prevention Awareness Program Plan (DOE-RL, 1998a) and Prime contractor implementation plans describing programs required by Resource Conservation and Recovery Act of 1976 (RCRA) 3002(b) and 3005(h) (RCRA and EPA, 1994). Documentation guidance for the following five P2/WMin elements are discussed: Fiscal Year (FY) Goals; Budget and Staffing; Waste Minimization (WMin) Assessments (WMAs); Quarterly Pollution Prevention (P2) Reporting WMin Certification.

  5. Human factors design guidelines for maintainability of Department of Energy nuclear facilities

    SciTech Connect (OSTI)

    Bongarra, J.P. Jr.; VanCott, H.P.; Pain, R.F.; Peterson, L.R.; Wallace, R.I.

    1985-06-18

    Intent of these guidelines is to provide design and design review teams of DOE nuclear facilities with human factors principles to enhance the design and aid in the inspection of DOE nuclear facilities, systems, and equipment. These guidelines are concerned with design features of DOE nuclear facilities which can potentially affect preventive and corrective maintenance of systems within DOE nuclear facilities. Maintenance includes inspecting, checking, troubleshooting, adjusting, replacing, repairing, and servicing activities. Other factors which influence maintainability such as repair and maintenance suport facilities, maintenance information, and various aspects of the environment are also addressed.

  6. Three-phase uninterruptible power supply maintaining reserve energy sources in idling condition with unbalanced loads

    SciTech Connect (OSTI)

    Boettcher, C.W.; Hamilton, B.H.; Zweig, W.L.

    1980-12-09

    A control arrangement for a three-phase, uninterruptible power supply generates timing signals to drive the static switches of inverters located in each phase. This control arrangement precisely controls the phase differences of the inverter signals with relation to each other so that while the overall three-phase power supplied by the inverters is nulled, power circulation through the inverters compensates for unbalanced output loads thereby maintaining balanced phase angles between the output voltage and a balanced input impedance at the input of the power supply.

  7. NEPA and the Clean Air Act: Complementary approaches to maintaining air quality

    SciTech Connect (OSTI)

    Miller, R.L.; McCold, L.N.

    1991-01-01

    The National Environmental Policy Act (NEPA) of 1969 was established to prevent or eliminate damage to the environmental and biosphere from federal actions and stimulate the public health and welfare. An intertwined focus of NEPA has been to create and maintain conditions under which people and nature can exist in productive harmony. Meanwhile, the Clean Air Act (CAA) and amendments are the basis for regulating emission of air pollutants and otherwise maintaining or enhancing air quality to protect public health and welfare throughout the United States. Because the CAA is to comprehensive, a frequently asked question concerns the usefulness of NEPA from an air quality perspective: What can NEPA accomplish for federal actions that is not already accomplished by the CAA This paper contends that NEPA plays an important role in identifying and informing federal decision-makers of potential air quality impacts of federal actions. NEPA encompasses a broader scope and provides an independent analysis of CAA requirements for federal actions. NEPA ensures that spectrum of potential environmental effects is examined, rather than air quality alone. In some cases, NEPA analyses involve evaluating trade-offs of beneficial and adverse effects among different environmental media, such as air emissions vs solid waste. NEPA air quality analyses sometimes encompass potential concerns that are beyond those required for compliance with the CAA. Also, the environmental consequences of alternative actions are assessed to assist federal decision-makers in selecting a preferred alternative. Finally, proposed federal programs are evaluated under NEPA for their potential effects. 8 refs.

  8. Functional Materials

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Functional Materials Researchers in NETL's Functional Materials Development competency work to discover and develop advanced functional materials and component processing technologies to meet technology performance requirements and enable scale-up for proof-of-concept studies. Research includes separations materials and electrochemical and magnetic materials, specifically: Separations Materials Synthesis, purification, and basic characterization of organic substances, including polymers and

  9. The Need for Essential Consumer Protections: Smart metering proposals and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the move to time-based pricing. August 2010 | Department of Energy metering proposals and the move to time-based pricing. August 2010 The Need for Essential Consumer Protections: Smart metering proposals and the move to time-based pricing. August 2010 There is widespread consensus that the U.S. distribution and transmission systems for vital electricity service need to be modernized and upgraded. This modernization has been recently promoted under the rubric of the Smart Grid. The Smart Grid

  10. On the essential spectrum of certain non-commutative oscillators

    SciTech Connect (OSTI)

    Parmeggiani, Alberto Venni, Alberto

    2013-12-15

    We show here that the spectrum of the family of non-commutative harmonic oscillators Q{sub (α,β)}{sup w}(x,D) for α,β∈R{sub +} in the range αβ = 1 is [0, +∞) and is entirely essential spectrum. The previous existing results concern the case αβ > 1 (case in which Q{sub (α,β)}{sup w}(x,D) is globally elliptic with a discrete spectrum whose qualitative properties are being extensively studied), and ours therefore extend the picture to the range of parameters αβ ⩾ 1.

  11. Hanford Site Guide for Preparing and Maintaining Generator Group Pollution Prevention Program Documentation

    SciTech Connect (OSTI)

    PLACE, B.G.

    2001-11-01

    This document provides guidance to generator groups for preparing and maintaining documentation of Pollution Prevention/Waste Minimization (P2/WMin) hogram activities. The guidance is one of a hierarchical series that includes the ''Hanford Site Waste Minimization and Pollution Prevention Awareness Program Plan'' (DOE-RL, 2001) and Prime Contractor implementation plans describing programs required by ''Resource Conservation and Recovery Act of 1976'' (RCRA) 3002(b) and 3005(h) (RCRA and EPA, 1994) and Department of Energy Acquisition Regulations (DEAR) (48 CFR 970.5204-2 and 48 CFR 970.5204-78). Documentation guidance for the following five P2/WMin elements is discussed: (1) Fiscal Year (FY) Goals; (2) Budget and Staffing; (3) Waste Minimization (WMin) Assessments (WMAs); (4) Pollution Prevention (P2) Reporting; and (5) WMin Certification.

  12. Apparatus for maintaining alignment of a shrinking weld joint in an electron-beam welding operation

    DOE Patents [OSTI]

    Trent, Jett B.; Murphy, Jimmy L.

    1981-01-01

    The present invention is directed to an apparatus for automatically maintaining a shrinking weld joint in alignment with an electron beam during an electron-beam multipass-welding operation. The apparatus utilizes a biasing device for continually urging a workpiece-supporting face plate away from a carriage mounted base that rotatably supports the face plate. The extent of displacement of the face plate away from the base is indicative of the shrinkage occuring in the weld joint area. This displacement is measured and is used to move the base on the carriage a distance equal to one-half the displacement for aligning the weld joint with the electron beam during each welding pass.

  13. Apparatus for maintaining aligment of a shrinking weld joint in an electron-beam welding operation

    DOE Patents [OSTI]

    Trent, J.B.; Murphy, J.L.

    1980-01-03

    The invention is directed to an apparatus for automatically maintaining a shrinking weld joint in alignement with an electron beam during an electron-beam multipass-welding operation. The apparatus utilizes a bias means for continually urging a workpiece-supporting face plate away from a carriage mounted base that rotatably supports the face plate. The extent of displacement of the face plate away from the base in indicative of the shrinkage occuring in the weld joint area. This displacement is measured and is used to move the base on the carriage a distance equal to one-half the displacement for aligning the weld joint with the electron beam during each welding pass.

  14. Hanford Site Guide for Preparing and Maintaining Generator Group Pollution Prevention Program Documentation

    SciTech Connect (OSTI)

    PLACE, B.G.

    2000-11-01

    This document provides guidance to generator groups for preparing and maintaining documentation of Pollution Prevention/Waste Minimization (P2/WMin) Program activities. The guidance is one of a hierarchical series that includes the Hanford Site Waste Minimization and Pollution Prevention Awareness Program Plan (DOE-RL, 2000) and Prime Contractor implementation plans describing programs required by Resource Conservation and Recovery Act of 1976 (RCRA) 3002(b) and 3005(h) (RCRA and EPA, 1994) and Department of Energy Acquisition Regulations (DEAR) (48 CFR 970.5204-2 and 48 CFR 970.5204-78). Documentation guidance for the following five P2/WMin elements is discussed: Fiscal Year (FY) Goals; Budget and Staffing; Pollution Prevention (P2) Reporting; WMin Certification; and Waste Minimization (WMin) Assessments (WMAs).

  15. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration

    SciTech Connect (OSTI)

    Simarro, Maria; Gimenez-Cassina, Alfredo; Kedersha, Nancy; Lazaro, Jean-Bernard; Adelmant, Guillaume O.; Marto, Jarrod A.; Rhee, Kirsten; Tisdale, Sarah; Danial, Nika; Benarafa, Charaf; Orduna, Anonio; Anderson, Paul

    2010-10-22

    Research highlights: {yields} Five members of the FAST kinase domain-containing proteins are localized to mitochondria in mammalian cells. {yields} The FASTKD3 interactome includes proteins involved in various aspects of mitochondrial metabolism. {yields} Targeted knockdown of FASTKD3 significantly reduces basal and maximal mitochondrial oxygen consumption. -- Abstract: Fas-activated serine/threonine phosphoprotein (FAST) is the founding member of the FAST kinase domain-containing protein (FASTKD) family that includes FASTKD1-5. FAST is a sensor of mitochondrial stress that modulates protein translation to promote the survival of cells exposed to adverse conditions. Mutations in FASTKD2 have been linked to a mitochondrial encephalomyopathy that is associated with reduced cytochrome c oxidase activity, an essential component of the mitochondrial electron transport chain. We have confirmed the mitochondrial localization of FASTKD2 and shown that all FASTKD family members are found in mitochondria. Although human and mouse FASTKD1-5 genes are expressed ubiquitously, some of them are most abundantly expressed in mitochondria-enriched tissues. We have found that RNA interference-mediated knockdown of FASTKD3 severely blunts basal and stress-induced mitochondrial oxygen consumption without disrupting the assembly of respiratory chain complexes. Tandem affinity purification reveals that FASTKD3 interacts with components of mitochondrial respiratory and translation machineries. Our results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration.

  16. Histone demethylase JMJD5 is essential for embryonic development

    SciTech Connect (OSTI)

    Oh, Sangphil; Janknecht, Ralf

    2012-03-30

    Highlights: Black-Right-Pointing-Pointer Histone demethylase JMJD5 is essential for embryogenesis. Black-Right-Pointing-Pointer Transcription of tumor suppressor p53 is upregulated in JMJD5 knockout embryos. Black-Right-Pointing-Pointer JMJD5 may antagonize p53-dependent growth inhibition and apoptosis. Black-Right-Pointing-Pointer JMJD5 is overexpressed in leukemias and breast cancer. -- Abstract: Histone lysine methylation is pivotal in regulating chromatin structure and thus profoundly affects the transcriptome. JMJD5 (jumonji C domain-containing 5) is a histone demethylase that specifically removes methyl moieties from dimethylated lysine 36 on histone H3 and exerts a pro-proliferative effect on breast cancer cells. Here, we generated JMJD5 knockout mice in order to study the physiological significance of this enzyme. Whereas heterozygous knockout mice displayed no overt phenotype, homozygous JMJD5 knockouts died around day 10 of embryonal development. JMJD5{sup -/-} embryos showed delayed development already at E8.5 and were actively resorbed at E10.5. While strong JMJD5 expression was observed only in the yolk sac at E8.5, JMJD5 was robustly expressed in E10.5 embryos at several sites, including the heart and eye. Lack of JMJD5 resulted in transcriptional upregulation of the tumor suppressor p53. Concurrently, the cell cycle inhibitor p21 and the pro-apoptotic molecule Noxa, both of which are prominent p53 target genes, became strongly upregulated in JMJD5{sup -/-} embryos. Collectively, our data indicate that JMJD5 is essential during embryonal development and a repressor of p53 expression. The latter suggests that JMJD5 has oncogenic activity and accordingly JMJD5 is upregulated in leukemias and breast cancer.

  17. Current practices for maintaining occupational exposures ALARA at low-level waste disposal sites

    SciTech Connect (OSTI)

    Hadlock, D.E.; Herrington, W.N.; Hooker, C.D.; Murphy, D.W.; Gilchrist, R.L.

    1983-12-01

    The United States Nuclear Regulatory Commission contracted with Pacific Northwest Laboratory (PNL) to provide technical assistance in establishing operational guidelines, with respect to radiation control programs and methods of minimizing occupational radiation exposure, at Low-Level Waste (LLW) disposal sites. The PNL, through site visits, evaluated operations at LLW disposal sites to determine the adequacy of current practices in maintaining occupational exposures as low as is reasonably achievable (ALARA). The data sought included the specifics of: ALARA programs, training programs, external exposure control, internal exposure control, respiratory protection, surveillance, radioactive waste management, facilities and equipment, and external dose analysis. The results of the study indicated the following: The Radiation Protection and ALARA programs at the three commercial LLW disposal sites were observed to be adequate in scope and content compared to similar programs at other types of nuclear facilities. However, it should be noted that there were many areas that could be improved upon to help ensure the health and safety of occupationally exposed individuals.

  18. Low-drag electrical-contact arrangement for maintaining continuity between horizontally movable members

    DOE Patents [OSTI]

    Brown, R.J.; Gerth, H.L.; Robinson, S.C.

    1981-01-23

    This invention is a low-drag electrical contact arrangement for establishing continuity between upper and lower spaced members which are subject to relative horizontal movement. In one aspect, the invention comprises an electrical commutating arrangement which includes a horizontally disposed linear electrical commutator. A horizontally movable electrically conductive pedestal is positioned below the commutator and defines a clearance therewith. The pedestal is formed with a cavity confronting the commutator. In the cavity is a bead of electrical conductive liquid, the bead being characterized by an upwardly convex meniscus portion which extends across the clearance and contacts the commutator. The surface tension of the bead is sufficient to maintain the bead intact when the commutator and pedestal are displaced horizontally at speeds from zero to at least twelve inches a minute. This arrangement provides a significant advance in highly precise machining processes, such as diamond-turning, where precision is limited by the drag imposed by conventional commutators of the carbon-brush type.

  19. Low-drag electrical contact arrangement for maintaining continuity between horizontally movable members

    DOE Patents [OSTI]

    Brown, R. Jack; Gerth, Howard L.; Robinson, Samuel C.

    1982-01-01

    This invention is a low-drag electrical contact arrangement for establishing continuity between upper and lower spaced members which are subject to relative horizontal movement. In one aspect, the invention comprises an electrical commutating arrangement which includes a horizontally disposed linear electrical commutator. A horizontally movable electrically conductive pedestal is positioned below the commutator and defines a clearance therewith. The pedestal is formed with a cavity confronting the commutator. In the cavity is a bead of electrical conductive liquid, the bead being characterized by an upwardly convex meniscus portion which extends across the clearance and contacts the commutator. The surface tension of the bead is sufficient to maintain the bead intact when the commutator and pedestal are displaced horizontally at speeds from zero to at least twelve inches a minute. This arrangement provides a significant advance in highly precise machining processes, such as diamond-turning, where precision is limited by the drag imposed by conventional commutators of the carbon-brush type.

  20. Maintaining safety class electrical and electronic equipment in the absence of support from original suppliers

    SciTech Connect (OSTI)

    Gantt, D.A.

    1991-05-01

    In the absence of a large market for nuclear-qualified equipment, many manufactures no longer provide the level of support necessary to maintain equipment, which they originally manufactured to nuclear qualification standards. As a result, the nuclear facility operator either must purchase commercial grade items and perform necessary conditioning and dedication, or purchase replacement equipment from a limited number of manufacturers of nuclear-qualified equipment. Westinghouse Hanford Company, in operating the Fast Flux Test Facility (FFTF), is using both of these approaches. Instrumentation power supplies and signal conditioners used in the FFTF Reactor Shutdown System of the Plant Protection System (PPS) are standard commercial devices that were qualified for PPS use through tests performed for the original system supplier. The US Department of Energy (DOE) Order 5700.6B mandates that all DOE facilities have a quality assurance program conforming to an appropriate national standard and recommends Quality Assurance Program Requirements for Nuclear Facilities, American National Standards Institute/American Society of Mechanical Engineers (ANSI/ASME) NQA-1, as the standard to implement for reactor facilities. Following the requirements of ANSI/ASME NQA-1 and the guidance in Electric Power Research Institute (EPRI) Report NP-5652, safety system parts can be purchased either as qualified items or as commercial grade items. This document discusses the process of procuring qualified replacement parts. 6 refs., 1 tab.

  1. Vehicle Technologies Office 2013 Merit Review: A System for Automatically Maintaining Pressure in a Commercial Truck Tire

    Broader source: Energy.gov [DOE]

    A presentation given by PPG during the 2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting on a system for automatically maintaining tire pressure in commercial truck tires.

  2. A rationale for maintaining the double containment requirement for plutonium shipments

    SciTech Connect (OSTI)

    Channell, James K.; Anastas, George

    2003-12-31

    Current U.S. Nuclear Regulatory Commission (NRC) transportation regulations (10 CFR 71.63 (b)) require that all shipments containing more than 20 curies of plutonium must be transported in packages that provide double containment. On April 30, 2002 the NRC issued a proposed rule that would eliminate 71.63(b) and the double containment requirement. NRCs reasons for proposing elimination of 71.63(b) are: (1) compatibility with International Atomic Energy Agency Transportation Safety Standards (which do not have the requirement); (2) the current rule is inconsistent with the A1/A2 system since it applies only to plutonium; (3) double containment causes a heavier package and results in higher transportation costs; (4) the separate inner containment results in additional radiation exposure; and (5) while there would be additional protection from a separate inner container in an accident; this type of approach is not risk informed nor performance based. The Environmental Evaluation Group (EEG) has been a proponent of the double containment requirement for the Waste Isolation Pilot Plant (WIPP) shipments for twenty years. This requirement affects shipments to WIPP much more than any other current or planned shipping campaign because reactor fuel elements, metal or metal alloy, and vitrified high-level waste are exempt from 71.63(b). EEG submitted comments on the Proposed Rule on July 26, 2002 (Appendix C). This report is an update and expansion of the July 26, 2002 comments. Actual WIPP experience with shipments in the double contained TRUPACT-II package is used to respond to NRC arguments for deletion of 71.63(b) and offers a rationale for maintaining the current requirement.

  3. Quantification of Libby Reservoir Levels Needed to Maintain or Enhance Reservoir Fisheries, 1985 Annual Report.

    SciTech Connect (OSTI)

    Chisholm, Ian

    1985-01-01

    The goal was to quantify seasonal water levels needed to maintain or enhance the reservoir fishery in Libby. This report summarizes data collected from July 1984 through July 1985, and, where appropriate, presents data collected since 1983. The Canada, Rexford, and Tenmile areas of the reservoir are differentially affected by drawdown. Relative changes in water volume and surface area are greatest in the Canada area and smallest in the Tenmile area. Reservoir morphology and hydraulics probably play a major role in fish distribution through their influence on water temperature. Greatest areas of habitat with optimum water temperature for Salmo spp. and kokanee occurred during the spring and fall months. Dissolved oxygen, pH and conductivity levels were not limiting during any sampling period. Habitat enhancement work was largely unsuccessful. Littoral zone vegetation plantings did not survive well, primarily the result of extreme water level fluctuations. Relative abundances of fish species varied seasonally within and between the three areas. Water temperature is thought to be the major influence in fish distribution patterns. Other factors, such as food availability and turbidity, may mitigate its influence. Sampling since 1975 illustrates a continued increase in kokanee numbers and a dramatic decline in redside shiners. Salmo spp., bull trout, and burbot abundances are relatively low while peamouth and coarsescale sucker numbers remain high. A thermal dynamics model and a trophic level components model will be used to quantify the impact of reservoir operation on the reservoir habitat, primary production, secondary production and fish populations. Particulate carbon will be used to track energy flow through trophic levels. A growth-driven population dynamics simulation model that will estimate the impacts of reservoir operation on fish population dynamics is also being considered.

  4. Definition and means of maintaining the ventilation system confinement portion of the PFP safety envelope

    SciTech Connect (OSTI)

    Dick, J.D.; Grover, G.A.; O`Brien, P.M., Fluor Daniel Hanford

    1997-03-05

    The Plutonium Finishing Plant Heating Ventilation and Cooling system provides for the confinement of radioactive releases to the environment and provides for the confinement of radioactive contamination within designated zones inside the facility. This document identifies the components and procedures necessary to ensure the HVAC system provides these functions. Appendices E through J provide a snapshot of non-safety class HVAC equipment and need not be updated when the remainder of the document and Appendices A through D are updated.

  5. Safety Management Functions, Responsibilities, and Authorities

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-05-22

    This Manual provides the responsibilities of Headquarters and field element offices required by DOE P 411.1, Safety Management Functions, Responsibilities and Authorities Policy, dated 1-28-97. It also contains detailed requirements to supplement the policy's direction for each DOE organization having safety management functions to establish and maintain separate documentation of their responsibilities and authorities. Cancels DOE M 411.1-1A. Canceled by DOE M 411.1-1C.

  6. Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice

    SciTech Connect (OSTI)

    Zhang, Pengpeng; Shan, Tizhong; Liang, Xinrong; Deng, Changyan; Kuang, Shihuan

    2014-09-12

    Highlights: mTOR is a critical regulator of many biological processes yet its function in heart is not well understood. MCK-Cre/Mtor{sup flox/flox} mice were established to delete Mtor in cardiomyocytes. The mTOR-mKO mice developed normally but die prematurely within 5 weeks after birth due to heart disease. The mTOR-mKO mice had dilated myocardium and increased cell death. mTOR-mKO hearts had reduced expression of metabolic genes and activation of mTOR target proteins. - Abstract: Mammalian target of rapamycin (mTOR) is a critical regulator of protein synthesis, cell proliferation and energy metabolism. As constitutive knockout of Mtor leads to embryonic lethality, the in vivo function of mTOR in perinatal development and postnatal growth of heart is not well defined. In this study, we established a muscle-specific mTOR conditional knockout mouse model (mTOR-mKO) by crossing MCK-Cre and Mtor{sup flox/flox} mice. Although the mTOR-mKO mice survived embryonic and perinatal development, they exhibited severe postnatal growth retardation, cardiac muscle pathology and premature death. At the cellular level, the cardiac muscle of mTOR-mKO mice had fewer cardiomyocytes due to apoptosis and necrosis, leading to dilated cardiomyopathy. At the molecular level, the cardiac muscle of mTOR-mKO mice expressed lower levels of fatty acid oxidation and glycolysis related genes compared to the WT littermates. In addition, the mTOR-mKO cardiac muscle had reduced Myh6 but elevated Myh7 expression, indicating cardiac muscle degeneration. Furthermore, deletion of Mtor dramatically decreased the phosphorylation of S6 and AKT, two key targets downstream of mTORC1 and mTORC2 mediating the normal function of mTOR. These results demonstrate that mTOR is essential for cardiomyocyte survival and cardiac muscle function.

  7. Elementary Functions

    Energy Science and Technology Software Center (OSTI)

    1986-05-01

    The ALTERNATIVE LIBRARY is a library of elementary functions prepared for use with the standard FORTRAN compiler under 4.2 BSD UNIX as an alternative to the standard system library. The library offers improved accuracy as well as additional capabilities. It includes routines ASIN, ACOS, COSH, EXP, LOG, LOG10, POW, SIN, COS, SINH, TAN, and TANH. These alternative routines have slightly modified domains and slightly different responses to invalid arguments. Four routines, not part of themore » standard library, are provided: ADX(X,N), a double-precision function that returns the double-precision argument X scaled by 2 raised to the Nth power; INTXP(X), an integer function that returns as a signed integer the exponent of the double-precision argument X; SETXP(X,N), a double-precision function that returns the double-precision argument X with its exponent replaced by N; and DCOTAN(X), a double-precision function that returns the cotangent of the double-precision argument X, where X is given in radians.« less

  8. Receptor expression is essential for proliferation induced by dimerized Jak kinases

    SciTech Connect (OSTI)

    Fujii, Hodaka

    2008-06-13

    Two members of Jak kinases, Jak1 and Jak3, are associated with the cytoplasmic domains of the interleukin-2 (IL-2) receptor (IL-2R) {beta} chain (IL-2R{beta}) and the common cytokine receptor {gamma} chain ({gamma}c), respectively, and accumulating evidence indicates their functional importance in IL-2 signaling. Here, I showed that coumermycin-induced chemical heterodimerization of Jak1 and Jak3 but not homodimerization of Jak1 or Jak3 induces cell proliferation of an IL-2R-reconstituted cell line. In this regard, expression of IL-2R{beta} was essential for cell proliferation by chemical heterodimerization of Jak1 and Jak3, indicating that dimerized Jak1 and Jak3 induce heterodimerization of IL-2R{beta} and {gamma}c, which may activate receptor-bound signaling molecules. Previous reports using chemical dimerization suggest that dimerization of Jak kinases is sufficient to induce cell proliferation. The present study indicates that re-evaluation of this conclusion is necessary and that interpretation of functional analysis of signaling molecules using chemical dimerizers needs more careful assessment.

  9. Process for functionalizing alkanes

    DOE Patents [OSTI]

    Bergman, Robert G.; Janowicz, Andrew H.; Periana-Pillai, Roy A.

    1985-01-01

    Process for functionalizing saturated hydrocarbons selectively in the terminal position comprising: (a) reacting said saturated hydrocarbons of the formula: RH where: H represents a hydrogen atom, and R represents a saturated hydrocarbon radical, with a metal complex of the formula: CpRhPMe.sub.3 H.sub.2 where: Cp represents a pentamethylated cyclopentadienyl radical, Rh represents a rhodium atom, P represents a phosphorous atom, Me represents a methyl group, H represents a hydrogen atom, in the presence of ultraviolet radiation at a temperature maintained at about -60.degree. to -17.degree. C. to form a hydridoalkyl complex of the formula: CpRhPMe.sub.3 RH (b) reacting said hydridoalkyl complex with a haloform of the formula: CHX.sub.3 where: X represents a bromine, iodine or chlorine atom, at a temperature in the range of about -60.degree. to -17.degree. C. to form the corresponding haloalkyl complex of step (a) having the formula: CpRhPMe.sub.3 RX; and, (c) reacting said haloalkyl complex formed in (b) with halogen (X.sub.2) at a temperature in the range of about -60.degree. to 25.degree. C. (i.e. ambient) to form a functional haloalkyl compound.

  10. Maintaining low exhaust emissions with turbocharged gas engines using a feedback air-fuel ratio control system

    SciTech Connect (OSTI)

    Eckard, D.W.; Serve, J.V.

    1987-10-01

    Maintaining low exhaust emissions on a turbocharged, natural gas engine through the speed and load range requires precise control of the air-fuel ratio. Changes in ambient conditions or fuel heating value will cause the air-fuel ratio to change substantially. By combining air-gas pressure with preturbine temperature control, the air-fuel ratio can be maintained regardless of changes in the ambient conditions or the fuel's heating value. Design conditions and operating results are presented for an air-fuel controller for a turbocharged engine.

  11. Definition and means of maintaining the emergency notification and evacuation system portion of the Plutonium Finishing Plant safety envelope

    SciTech Connect (OSTI)

    White, W.F.

    1997-04-21

    The Emergency Evacuation and Notification System provides information to the PFP Building Emergency Director to assist in determining appropriate emergency response, notifies personnel of the required response, and assists in their response. The report identifies the equipment in the Safety Envelope (SE) for this System and the Administrative, Maintenance, and Surveillance Procedures used to maintain the SE Equipment.

  12. Load requirements for maintaining structural integrity of Hanford single-shell tanks during waste feed delivery and retrieval activities

    SciTech Connect (OSTI)

    JULYK, L.J.

    1999-09-22

    This document provides structural load requirements and their basis for maintaining the structural integrity of the Hanford Single-Shell Tanks during waste feed delivery and retrieval activities. The requirements are based on a review of previous requirements and their basis documents as well as load histories with particular emphasis on the proposed lead transfer feed tanks for the privatized vitrification plant.

  13. Function Sequencer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    mFUSE: Function Sequencer for MATLAB Help Manual LANL/UCSD Engineering Institute LA-CC-10-033 LA-UR 10-01264 c Copyright 2010, Los Alamos National Security, LLC All rights reserved. July 29, 2010 LA-CC-10-033 LA-UR 10-01264 Contents I What is mFUSE? 4 1 Features . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2 Version Numbers . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3 About This Manual . . . . . . . . . . . . . . . . . . . . . . . . 6 4 Author Information . . . . .

  14. The actin family protein ARP6 contributes to the structure and the function of the nucleolus

    SciTech Connect (OSTI)

    Kitamura, Hiroshi; Matsumori, Haruka; Kalendova, Alzbeta; Hozak, Pavel; Goldberg, Ilya G.; Nakao, Mitsuyoshi; Saitoh, Noriko; Harata, Masahiko

    2015-08-21

    The actin family members, consisting of actin and actin-related proteins (ARPs), are essential components of chromatin remodeling complexes. ARP6, one of the nuclear ARPs, is part of the Snf-2-related CREB-binding protein activator protein (SRCAP) chromatin remodeling complex, which promotes the deposition of the histone variant H2A.Z into the chromatin. In this study, we showed that ARP6 influences the structure and the function of the nucleolus. ARP6 is localized in the central region of the nucleolus, and its knockdown induced a morphological change in the nucleolus. We also found that in the presence of high concentrations of glucose ARP6 contributed to the maintenance of active ribosomal DNA (rDNA) transcription by placing H2A.Z into the chromatin. In contrast, under starvation, ARP6 was required for cell survival through the repression of rDNA transcription independently of H2A.Z. These findings reveal novel pleiotropic roles for the actin family in nuclear organization and metabolic homeostasis. - Highlights: • ARP6, an actin related protein, is important for nucleolar function and structure. • A population of ARP6 is localized in the center of nucleolus. • Depletion of ARP6 resulted in aberrant shape of the nucleolus. • ARP6 maintains the active rDNA transcription under high glucose. • ARP6 is required for the repression of rDNA transcription under starvation.

  15. Trichodesmium genome maintains abundant, widespread noncoding DNA in situ, despite oligotrophic lifestyle

    SciTech Connect (OSTI)

    Walworth, Nathan G.; Pfreundt, Ulrike; Nelson, William C.; Mincer, Tracy; Heidelberg, John F.; Fu, Feixue; Waterbury, John B.; Glavina del Rio, T.; Goodwin, Lynne A.; Kyrpides, Nikos; Land, Miriam L.; Woyke, Tanja; Hutchins, David A.; Hess, Wolfgang R.; Webb, Eric A.

    2015-04-07

    Understanding the evolution of the free-living, cyanobacterial, diazotroph Trichodesmium is of great importance due to its critical role in oceanic biogeochemistry and primary production. Unlike the other >150 available genomes of free-living cyanobacteria, only 63.8% of the Trichodesmium erythraeum (strain IMS101) genome is predicted to encode protein, which is 20-25% less than the average for other cyanobacteria and non-pathogenic, free-living bacteria. We use distinctive isolates and metagenomic data to show that low coding density observed in IMS101 is a common feature of the Trichodesmium genus both in culture and in situ. Transcriptome analysis indicates that 86% of the non-coding space is expressed, although the function of these transcripts is unclear. The density of noncoding, possible regulatory elements predicted in Trichodesmium, when normalized per intergenic kilobase, was comparable and two fold higher than that found in the gene dense genomes of the sympatric cyanobacterial genera Synechococcus and Prochlorococcus, respectively. Conserved Trichodesmium ncRNA secondary structures were predicted between most culture and metagenomic sequences lending support to the structural conservation. Conservation of these intergenic regions in spatiotemporally separated Trichodesmium populations suggests possible genus-wide selection for their maintenance. These large intergenic spacers may have developed during intervals of strong genetic drift caused by periodic blooms of a subset of genotypes, which may have reduced effective population size. Our data suggest that transposition of selfish DNA, low effective population size, and high fidelity replication allowed the unusual inflation of noncoding sequence observed in Trichodesmium despite its oligotrophic lifestyle.

  16. Integrated Project Teams - An Essential Element of Project Management during Project Planning and Execution - 12155

    SciTech Connect (OSTI)

    Burritt, James G.; Berkey, Edgar

    2012-07-01

    Managing complex projects requires a capable, effective project manager to be in place, who is assisted by a team of competent assistants in various relevant disciplines. This team of assistants is known as the Integrated Project Team (IPT). he IPT is composed of a multidisciplinary group of people who are collectively responsible for delivering a defined project outcome and who plan, execute, and implement over the entire life-cycle of a project, which can be a facility being constructed or a system being acquired. An ideal IPT includes empowered representatives from all functional areas involved with a project-such as engineering design, technology, manufacturing, test and evaluation, contracts, legal, logistics, and especially, the customer. Effective IPTs are an essential element of scope, cost, and schedule control for any complex, large construction project, whether funded by DOE or another organization. By recently assessing a number of major, on-going DOE waste management projects, the characteristics of high performing IPTs have been defined as well as the reasons for potential IPT failure. Project managers should use IPTs to plan and execute projects, but the IPTs must be properly constituted and the members capable and empowered. For them to be effective, the project manager must select the right team, and provide them with the training and guidance for them to be effective. IPT members must treat their IPT assignment as a primary duty, not some ancillary function. All team members must have an understanding of the factors associated with successful IPTs, and the reasons that some IPTs fail. Integrated Project Teams should be used by both government and industry. (authors)

  17. A Godunov-like point-centered essentially Lagrangian hydrodynamic approach

    SciTech Connect (OSTI)

    Morgan, Nathaniel R.; Waltz, Jacob I.; Burton, Donald E.; Charest, Marc R.; Canfield, Thomas R.; Wohlbier, John G.

    2014-10-28

    We present an essentially Lagrangian hydrodynamic scheme suitable for modeling complex compressible flows on tetrahedron meshes. The scheme reduces to a purely Lagrangian approach when the flow is linear or if the mesh size is equal to zero; as a result, we use the term essentially Lagrangian for the proposed approach. The motivation for developing a hydrodynamic method for tetrahedron meshes is because tetrahedron meshes have some advantages over other mesh topologies. Notable advantages include reduced complexity in generating conformal meshes, reduced complexity in mesh reconnection, and preserving tetrahedron cells with automatic mesh refinement. A challenge, however, is tetrahedron meshes do not correctly deform with a lower order (i.e. piecewise constant) staggered-grid hydrodynamic scheme (SGH) or with a cell-centered hydrodynamic (CCH) scheme. The SGH and CCH approaches calculate the strain via the tetrahedron, which can cause artificial stiffness on large deformation problems. To resolve the stiffness problem, we adopt the point-centered hydrodynamic approach (PCH) and calculate the evolution of the flow via an integration path around the node. The PCH approach stores the conserved variables (mass, momentum, and total energy) at the node. The evolution equations for momentum and total energy are discretized using an edge-based finite element (FE) approach with linear basis functions. A multidirectional Riemann-like problem is introduced at the center of the tetrahedron to account for discontinuities in the flow such as a shock. Conservation is enforced at each tetrahedron center. The multidimensional Riemann-like problem used here is based on Lagrangian CCH work [8, 19, 37, 38, 44] and recent Lagrangian SGH work [33-35, 39, 45]. In addition, an approximate 1D Riemann problem is solved on each face of the nodal control volume to advect mass, momentum, and total energy. The 1D Riemann problem produces fluxes [18] that remove a volume error in the PCH

  18. A Godunov-like point-centered essentially Lagrangian hydrodynamic approach

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Morgan, Nathaniel R.; Waltz, Jacob I.; Burton, Donald E.; Charest, Marc R.; Canfield, Thomas R.; Wohlbier, John G.

    2014-10-28

    We present an essentially Lagrangian hydrodynamic scheme suitable for modeling complex compressible flows on tetrahedron meshes. The scheme reduces to a purely Lagrangian approach when the flow is linear or if the mesh size is equal to zero; as a result, we use the term essentially Lagrangian for the proposed approach. The motivation for developing a hydrodynamic method for tetrahedron meshes is because tetrahedron meshes have some advantages over other mesh topologies. Notable advantages include reduced complexity in generating conformal meshes, reduced complexity in mesh reconnection, and preserving tetrahedron cells with automatic mesh refinement. A challenge, however, is tetrahedron meshesmore » do not correctly deform with a lower order (i.e. piecewise constant) staggered-grid hydrodynamic scheme (SGH) or with a cell-centered hydrodynamic (CCH) scheme. The SGH and CCH approaches calculate the strain via the tetrahedron, which can cause artificial stiffness on large deformation problems. To resolve the stiffness problem, we adopt the point-centered hydrodynamic approach (PCH) and calculate the evolution of the flow via an integration path around the node. The PCH approach stores the conserved variables (mass, momentum, and total energy) at the node. The evolution equations for momentum and total energy are discretized using an edge-based finite element (FE) approach with linear basis functions. A multidirectional Riemann-like problem is introduced at the center of the tetrahedron to account for discontinuities in the flow such as a shock. Conservation is enforced at each tetrahedron center. The multidimensional Riemann-like problem used here is based on Lagrangian CCH work [8, 19, 37, 38, 44] and recent Lagrangian SGH work [33-35, 39, 45]. In addition, an approximate 1D Riemann problem is solved on each face of the nodal control volume to advect mass, momentum, and total energy. The 1D Riemann problem produces fluxes [18] that remove a volume error in the PCH

  19. Maintaining Your Air Conditioner

    Broader source: Energy.gov [DOE]

    Regular maintenance extends the life of your air conditioner and helps it run as efficiently as possible.

  20. Maintaining the Stockpile

    National Nuclear Security Administration (NNSA)

    %2A en Albuquerque Complex http:nnsa.energy.govaboutusourlocationsnnsa-complex

    Page...

  1. Maintaining the Stockpile

    National Nuclear Security Administration (NNSA)

    stockpilestewardshipdefensesciencedsfacilitieslansce" target"blank">Los Alamos Neutron Science Center (LANSCE), Los Alamos National Laboratory

  2. Apparatus for adjusting and maintaining the humidity of gas at a constant value within a closed system

    DOE Patents [OSTI]

    Abernathy, Bethel R.; Walters, Ronald R.

    1986-01-01

    The humidity of a gas within a closed system is maintained at constant level by providing a saturated salt solution within a lower chamber in communication with an upper chamber conjointly defined by upper and lower container sections in sealing contact with each other to establish a closed container. A partition wall separates the salt solution from the test region in the upper chamber. A tube extending through the partition plate allows humidified gas to pass from the lower to the upper chamber. A glass wool plug or membranous material within the tube prevents migration of salt into the test region.

  3. Apparatus for adjusting and maintaining the humidity of gas at a constant value within a closed system

    DOE Patents [OSTI]

    Abernathy, B.R.; Walters, R.R.

    1985-08-05

    The humidity of a gas within a closed system is maintained at constant level by providing a saturated salt solution within a lower chamber in communication with an upper chamber conjointly defined by upper and lower container sections in sealing contact with each other to establish a closed container. A partition wall separates the salt solution from the test region in the upper chamber. A tube extending through the partition plate allows humidified gas to pass from the lower to the upper chamber. A glass wool plug or membranous material within the tube prevents migration of salt into the test region.

  4. The Importance of Establishing and Maintaining Continuity of Knowledge during 21st Century Nuclear Fuel Cycle Activities

    SciTech Connect (OSTI)

    Pickett, Chris A; Rowe, Nathan C; Younkin, James R; Wishard, Bernard; Bean, Robert; Blair, Dianna; Lawson, Ray; Weeks, George; Tolk, Keith

    2012-01-01

    During this century, the entire nuclear fuel cycle will expand and become increasingly more global, taxing both the resources and capabilities of the International Atomic Energy Agency (IAEA) to maintain an effective Continuity of Knowledge (CoK) and its ability to provide timely detection of diversion. Uranium that currently is mined and milled in one country will be converted, enriched, and fabricated into fuel for reactors in an expanding set of new countries. This expansion will make it harder to guarantee that regional activities stay regional and that diversion detection is timely unless new and sustainable tools are developed to improve inspector effectiveness. To deal with this emerging reality, the IAEA must increase its use of unattended monitoring and employ new tools and methods that enhance CoK during all phases of the fuel cycle. This approach will help provide useful information to aid in detecting undeclared activities and create opportunities for timely and appropriate responses to events well before they enter phases of greater concern (e.g., enrichment). The systems that maintain CoK of safeguarded assets rely on containment and surveillance (C/S) technologies. The 21st century fuel cycle will require increased use of these technologies and systems, plus greater implementation of unattended systems that can securely collect data when inspectors are not present.

  5. A STUDY OF FISCHER 344 RATS EXPOSED TO SILICA DUST AT CONCENTRATIONS OF 0, 2, 10 OR 20 MG/M3, THEN MAINTAINED FOR SIX MONTHS PRIOR TO ASSESSMENT.

    SciTech Connect (OSTI)

    KUTZMAN,R.S.

    1984-11-01

    The major objective of this study was to relate the results of a series of functional tests to the compositional and structural alterations in the rat lung induced by subchronic exposure to silica dust. To induce a fibrotic lesion, Fischer-344 rats were exposed to either 0, 2, 10, or 20 mg Si0{sub 2}/m{sup 3} for 6 hours/day, 5 days/week for six months and then maintained in an animal room, equipped with a laminar flow unit, for six months prior to assessment of the end points.

  6. Advanced Inverter Functions to Support High Levels of Distributed Solar: Policy and Regulatory Considerations (Brochure)

    SciTech Connect (OSTI)

    Not Available

    2014-11-01

    This paper explains how advanced inverter functions (sometimes called 'smart inverters') contribute to the integration of high levels of solar PV generation onto the electrical grid and covers the contributions of advanced functions to maintaining grid stability. Policy and regulatory considerations associated with the deployment of advanced inverter functions are also introduced.

  7. Vermont Land Use: Essentials of Local Land Use Planning and Regulation...

    Open Energy Info (EERE)

    Use: Essentials of Local Land Use Planning and Regulation Jump to: navigation, search OpenEI Reference LibraryAdd to library PermittingRegulatory Guidance - GuideHandbook:...

  8. Combined Heat and Power (CHP): Essential for a Cost Effective Clean Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Standard, April 2011 | Department of Energy : Essential for a Cost Effective Clean Energy Standard, April 2011 Combined Heat and Power (CHP): Essential for a Cost Effective Clean Energy Standard, April 2011 In March 2011, a federal Clean Energy Standard (CES) was put forth as an approach to advancing a new national energy policy. This white paper discusses the CES concept. chp_clean_energy_std.pdf (973.28 KB) More Documents & Publications The International CHP/DHC Collaborative -

  9. Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system

    SciTech Connect (OSTI)

    Lountos, George T.; Tropea, Joseph E.; Waugh, David S.

    2012-09-17

    The Yersinia pestis YscD protein is an essential component of the type III secretion system. YscD consists of an N-terminal cytoplasmic domain (residues 1-121), a transmembrane linker (122-142) and a large periplasmic domain (143-419). Both the cytoplasmic and the periplasmic domains are required for the assembly of the type III secretion system. Here, the structure of the YscD cytoplasmic domain solved by SAD phasing is presented. Although the three-dimensional structure is similar to those of forkhead-associated (FHA) domains, comparison with the structures of canonical FHA domains revealed that the cytoplasmic domain of YscD lacks the conserved residues that are required for binding phosphothreonine and is therefore unlikely to function as a true FHA domain.

  10. Twin-tailed fail-over for fileservers maintaining full performance in the presence of a failure

    DOE Patents [OSTI]

    Coteus, Paul W.; Gara, Alan G.; Giampapa, Mark E.; Heidelberger, Philip; Steinmacher-Burow, Burkhard D.

    2008-02-12

    A method for maintaining full performance of a file system in the presence of a failure is provided. The file system having N storage devices, where N is an integer greater than zero and N primary file servers where each file server is operatively connected to a corresponding storage device for accessing files therein. The file system further having a secondary file server operatively connected to at least one of the N storage devices. The method including: switching the connection of one of the N storage devices to the secondary file server upon a failure of one of the N primary file servers; and switching the connections of one or more of the remaining storage devices to a primary file server other than the failed file server as necessary so as to prevent a loss in performance and to provide each storage device with an operating file server.

  11. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Print Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is a process critical to the life and death of a cell. Membrane transport proteins-functioning either as

  12. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Print Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is a process critical to the life and death of a cell. Membrane transport proteins-functioning either as

  13. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Print Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is a process critical to the life and death of a cell. Membrane transport proteins-functioning either as

  14. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Structures for Three Membrane Transport Proteins Yield Functional Insights Print Wednesday, 27 January 2010 00:00 Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is

  15. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Print Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is a process critical to the life and death of a cell. Membrane transport proteins-functioning either as

  16. Maintaining a Technology-Neutral Approach to Hydrogen Production Process Development through Conceptual Design of the Next Generation Nuclear Plant

    SciTech Connect (OSTI)

    Michael W. Patterson

    2008-05-01

    . For integration purposes, an analysis comparing the design, cost and schedule impact of maintaining a technology neutral approach through conceptual design or making an early hydrogen process technology selection was performed. Early selection does not specifically eliminate a technology, but rather selects the first hydrogen technology for demonstration. A systems-engineering approach was taken to define decision-making criteria for selecting a hydrogen technology. The relative technical, cost and schedule risks of each approach were analyzed and risk mitigation strategies were recommended, including provisions to maintain close collaboration with the NHI. The results of these analyses are presented here.

  17. Year 2 Report: Protein Function Prediction Platform

    SciTech Connect (OSTI)

    Zhou, C E

    2012-04-27

    Upon completion of our second year of development in a 3-year development cycle, we have completed a prototype protein structure-function annotation and function prediction system: Protein Function Prediction (PFP) platform (v.0.5). We have met our milestones for Years 1 and 2 and are positioned to continue development in completion of our original statement of work, or a reasonable modification thereof, in service to DTRA Programs involved in diagnostics and medical countermeasures research and development. The PFP platform is a multi-scale computational modeling system for protein structure-function annotation and function prediction. As of this writing, PFP is the only existing fully automated, high-throughput, multi-scale modeling, whole-proteome annotation platform, and represents a significant advance in the field of genome annotation (Fig. 1). PFP modules perform protein functional annotations at the sequence, systems biology, protein structure, and atomistic levels of biological complexity (Fig. 2). Because these approaches provide orthogonal means of characterizing proteins and suggesting protein function, PFP processing maximizes the protein functional information that can currently be gained by computational means. Comprehensive annotation of pathogen genomes is essential for bio-defense applications in pathogen characterization, threat assessment, and medical countermeasure design and development in that it can short-cut the time and effort required to select and characterize protein biomarkers.

  18. Maintaining a Critical Spectra within Monteburns for a Gas-Cooled Reactor Array by Way of Control Rod Manipulation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adigun, Babatunde John; Fensin, Michael Lorne; Galloway, Jack D.; Trellue, Holly Renee

    2016-06-07

    Our burnup study examined the effect of a predicted critical control rod position on the nuclide predictability of several axial and radial locations within a 4×4 graphite moderated gas cooled reactor fuel cluster geometry. To achieve this, a control rod position estimator (CRPE) tool was developed within the framework of the linkage code Monteburns between the transport code MCNP and depletion code CINDER90, and four methodologies were proposed within the tool for maintaining criticality. Two of the proposed methods used an inverse multiplication approach - where the amount of fissile material in a set configuration is slowly altered until criticalitymore » is attained - in estimating the critical control rod position. Another method carried out several MCNP criticality calculations at different control rod positions, then used a linear fit to estimate the critical rod position. The final method used a second-order polynomial fit of several MCNP criticality calculations at different control rod positions to guess the critical rod position. The results showed that consistency in prediction of power densities as well as uranium and plutonium isotopics was mutual among methods within the CRPE tool that predicted critical position consistently well. Finall, while the CRPE tool is currently limited to manipulating a single control rod, future work could be geared toward implementing additional criticality search methodologies along with additional features.« less

  19. Wave-function functionals for the density

    SciTech Connect (OSTI)

    Slamet, Marlina; Pan Xiaoyin; Sahni, Viraht

    2011-11-15

    We extend the idea of the constrained-search variational method for the construction of wave-function functionals {psi}[{chi}] of functions {chi}. The search is constrained to those functions {chi} such that {psi}[{chi}] reproduces the density {rho}(r) while simultaneously leading to an upper bound to the energy. The functionals are thereby normalized and automatically satisfy the electron-nucleus coalescence condition. The functionals {psi}[{chi}] are also constructed to satisfy the electron-electron coalescence condition. The method is applied to the ground state of the helium atom to construct functionals {psi}[{chi}] that reproduce the density as given by the Kinoshita correlated wave function. The expectation of single-particle operators W={Sigma}{sub i}r{sub i}{sup n}, n=-2,-1,1,2, W={Sigma}{sub i}{delta}(r{sub i}) are exact, as must be the case. The expectations of the kinetic energy operator W=-(1/2){Sigma}{sub i}{nabla}{sub i}{sup 2}, the two-particle operators W={Sigma}{sub n}u{sup n}, n=-2,-1,1,2, where u=|r{sub i}-r{sub j}|, and the energy are accurate. We note that the construction of such functionals {psi}[{chi}] is an application of the Levy-Lieb constrained-search definition of density functional theory. It is thereby possible to rigorously determine which functional {psi}[{chi}] is closer to the true wave function.

  20. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Extracting the Eliashberg Function Print Wednesday, 23 February 2005 00:00 A multitude of important chemical, physical, and biological phenomena...

  1. Integrated in silico analyses of regulatory and metabolic networks of Synechococcus sp. PCC 7002 reveal relationships between gene centrality and essentiality

    SciTech Connect (OSTI)

    Song, Hyun-Seob; McClure, Ryan S.; Bernstein, Hans C.; Overall, Christopher C.; Hill, Eric A.; Beliaev, Alex S.

    2015-03-27

    Cyanobacteria dynamically relay environmental inputs to intracellular adaptations through a coordinated adjustment of photosynthetic efficiency and carbon processing rates. The output of such adaptations is reflected through changes in transcriptional patterns and metabolic flux distributions that ultimately define growth strategy. To address interrelationships between metabolism and regulation, we performed integrative analyses of metabolic and gene co-expression networks in a model cyanobacterium, Synechococcus sp. PCC 7002. Centrality analyses using the gene co-expression network identified a set of key genes, which were defined here as ‘topologically important.’ Parallel in silico gene knock-out simulations, using the genome-scale metabolic network, classified what we termed as ‘functionally important’ genes, deletion of which affected growth or metabolism. A strong positive correlation was observed between topologically and functionally important genes. Functionally important genes exhibited variable levels of topological centrality; however, the majority of topologically central genes were found to be functionally essential for growth. Subsequent functional enrichment analysis revealed that both functionally and topologically important genes in Synechococcus sp. PCC 7002 are predominantly associated with translation and energy metabolism, two cellular processes critical for growth. This research demonstrates how synergistic network-level analyses can be used for reconciliation of metabolic and gene expression data to uncover fundamental biological principles.

  2. Integrated in silico analyses of regulatory and metabolic networks of Synechococcus sp. PCC 7002 reveal relationships between gene centrality and essentiality

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Song, Hyun-Seob; McClure, Ryan S.; Bernstein, Hans C.; Overall, Christopher C.; Hill, Eric A.; Beliaev, Alex S.

    2015-03-27

    Cyanobacteria dynamically relay environmental inputs to intracellular adaptations through a coordinated adjustment of photosynthetic efficiency and carbon processing rates. The output of such adaptations is reflected through changes in transcriptional patterns and metabolic flux distributions that ultimately define growth strategy. To address interrelationships between metabolism and regulation, we performed integrative analyses of metabolic and gene co-expression networks in a model cyanobacterium, Synechococcus sp. PCC 7002. Centrality analyses using the gene co-expression network identified a set of key genes, which were defined here as ‘topologically important.’ Parallel in silico gene knock-out simulations, using the genome-scale metabolic network, classified what we termedmore » as ‘functionally important’ genes, deletion of which affected growth or metabolism. A strong positive correlation was observed between topologically and functionally important genes. Functionally important genes exhibited variable levels of topological centrality; however, the majority of topologically central genes were found to be functionally essential for growth. Subsequent functional enrichment analysis revealed that both functionally and topologically important genes in Synechococcus sp. PCC 7002 are predominantly associated with translation and energy metabolism, two cellular processes critical for growth. This research demonstrates how synergistic network-level analyses can be used for reconciliation of metabolic and gene expression data to uncover fundamental biological principles.« less

  3. Truck Essential Power Systems Efficiency Improvements for Medium-Duty Trucks

    SciTech Connect (OSTI)

    Larry Slone; Jeffery Birkel

    2007-12-31

    With a variety of hybrid vehicles available in the passenger car market, electric technologies and components of that scale are becoming readily available. Commercial vehicle segments have lagged behind passenger car markets, leaving opportunities for component and system development. Escalating fuel prices impact all markets and provide motivation for OEMs, suppliers, customers, and end-users to seek new techniques and technologies to deliver reduced fuel consumption. The research presented here specifically targets the medium-duty (MD), Class 4-7, truck market with technologies aimed at reducing fuel consumption. These technologies could facilitate not only idle, but also parasitic load reductions. The development efforts here build upon the success of the More Electric Truck (MET) demonstration program at Caterpillar Inc. Employing a variety of electric accessories, the MET demonstrated the improvement seen with such technologies on a Class 8 truck. The Truck Essential Power Systems Efficiency Improvements for Medium-Duty Trucks (TEPS) team scaled the concepts and successes of MET to a MD chassis. The team designed an integrated starter/generator (ISG) package and energy storage system (ESS), explored ways to replace belt and gear-driven accessory systems, and developed supervisory control algorithms to direct the usage of the generated electricity and system behavior on the vehicle. All of these systems needed to fit within the footprint of a MD vehicle and be compatible with the existing conventional systems to the largest extent possible. The overall goal of this effort was to demonstrate a reduction in fuel consumption across the drive cycle, including during idle periods, through truck electrification. Furthermore, the team sought to evaluate the benefits of charging the energy storage system during vehicle braking. The vehicle features an array of electric accessories facilitating on-demand, variable actuation. Removal of these accessories from the belt or

  4. Transportation Organization and Functions

    Broader source: Energy.gov [DOE]

    Office of Packaging and Transportation list of organizations and functions, with a list of acronyms.

  5. DOE Office of Indian Energy Professional Course: Tribal Renewable Energy Project Development and Financing Essentials Text Version

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Professional Courses: Tribal Renewable Energy Project Development and Financing Essentials (text version) Below is the text version of the Webinar titled "DOE Office of Indian Energy Professional Course: Tribal Renewable Energy Development and Financing Essentials." Slide 1 Sara Farrar-Nagy: Hello. I'm Sara Farrar-Nagy with the National Renewable Energy Laboratory. Welcome to today's webinar on tribal renewable energy project development and financing essentials sponsored by the U.S.

  6. Essential Role in Modern Science William E. Johnston, ESnet Adviser and Senior Scientist

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Evolution of Research and Education Networks and their Essential Role in Modern Science William E. Johnston, ESnet Adviser and Senior Scientist Chin Guok, Evangelos Chaniotakis, Kevin Oberman, Eli Dart, Joe Metzger and Mike O'Conner, Core Engineering, Brian Tierney, Advanced Development, Mike Helm and Dhiva Muruganantham, Federated Trust Steve Cotter, Department Head wej@es.net, this talk is available at www.es.net Energy Sciences Network Lawrence Berkeley National Laboratory Networking for the

  7. Teaming/Subcontracting Essential to Small Business Success Presented by: Tiki Dixon

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Teaming/Subcontracting Essential to Small Business Success Presented by: Tiki Dixon Vice President, Tetra Tech Dating Opportunities with Large Business * Blind date * Caught my eye * Formal introduction Right time, right place 2 Building a Relationship with Large Business * Talking to the right person * Expectations of the relationship * Focusing on core company capabilities * Investing in the relationship Where are we going? 3 Engagement to Each Other * Building on a trusting relationship *

  8. DOE Office of Indian Energy Tribal Renewable Energy Project Development and Financing Essentials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Renewable Energy Project Development and Financing Essentials Introduction The U.S. Department of Energy (DOE) Office of Indian Energy Policy and Programs is responsible for assisting Tribes with energy planning and development, infrastructure, energy costs, and electrification of Indian lands and homes. As part of this commitment and on behalf of DOE, the Office of Indian Energy is leading education and capacity building efforts in Indian Country. 2 About the Speaker Elizabeth Doris * Senior

  9. The Evolution of Research and Education Networks and their Essential Role in

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be published in: "Trends in High Performance & Large Scale Computing" Lucio Grandinetti and Gerhard Joubert editors, IOS Press publisher The Evolution of Research and Education Networks and their Essential Role in Modern Science William JOHNSTON, Evangelos CHANIOTAKIS, Eli DART, Chin GUOK, Joe METZGER, Brian TIERNEY ESnet, Lawrence Berkeley National Laboratory † Abstract. ESnet - the Energy Sciences Network - has the mission of enabling the aspects of the US Department of

  10. Design criteria document, Fire Protection Task, K Basin Essential Systems Recovery, Project W-405

    SciTech Connect (OSTI)

    Johnson, B.H.

    1994-12-14

    The K Basin were constructed in the early 1950`s with a 20 year design life. The K Basins are currently in their third design life and are serving as a near term storage facility for irradiated N Reactor fuel until an interim fuel storage solution can be implemented. In April 1994, Project W-405, K Basin Essential Systems Recovery, was established to address (among other things) the immediate fire protection needs of the 100K Area. A Fire Barrier Evaluation was performed for the wall between the active and inactive areas of the 105KE and 105KW buildings. This evaluation concludes that the wall is capable of being upgraded to provide an equivalent level of fire resistance as a qualified barrier having a fire resistance rating of 2 hours. The Fire Protection Task is one of four separate Tasks included within the scope of Project W405, K Basin Essential systems Recovery. The other three Tasks are the Water Distribution System Task, the Electrical System Task, and the Maintenance Shop/Support Facility Task. The purpose of Project W-405`s Fire Protection Task is to correct Life Safety Code (NFPA 101) non-compliances and to provide fire protection features in Buildings 105KE, 105KW and 190KE that are essential for assuring the safe operation and storage of spent nuclear fuel at the 100K Area Facilities` Irradiated Fuel Storage Basins (K Basins).

  11. Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ji, Quanjiang; Chen, Peter J.; Qin, Guangrong; Deng, Xin; Hao, Ziyang; Wawrzak, Zdzislaw; Yeo, Won -Sik; Quang, Jenny Winjing; Cho, Hoonsik; Luo, Guan -Zheng; et al

    2016-03-18

    Most low GC Gram-positive bacteria possess an essential walKR two-component system (TCS) for signal transduction involved in regulating cell wall homoeostasis. Despite the well-established intracellular regulatory mechanism, the role of this TCS in extracellular signal recognition and factors that modulate the activity of this TCS remain largely unknown. Here we identify the extracellular receptor of the kinase ‘WalK’ (erWalK) as a key hub for bridging extracellular signal input and intracellular kinase activity modulation in Staphylococcus aureus. Characterization of the crystal structure of erWalK revealed a canonical Per-Arnt-Sim (PAS) domain for signal sensing. Single amino-acid mutation of potential signal-transduction residues resultedmore » in severely impaired function of WalKR. A small molecule derived from structure-based virtual screening against erWalK is capable of selectively activating the walKR TCS. Lastly, the molecular level characterization of erWalK will not only facilitate exploration of natural signal(s) but also provide a template for rational design of erWalK inhibitors.« less

  12. Functionalized boron nitride nanotubes

    DOE Patents [OSTI]

    Sainsbury, Toby; Ikuno, Takashi; Zettl, Alexander K

    2014-04-22

    A plasma treatment has been used to modify the surface of BNNTs. In one example, the surface of the BNNT has been modified using ammonia plasma to include amine functional groups. Amine functionalization allows BNNTs to be soluble in chloroform, which had not been possible previously. Further functionalization of amine-functionalized BNNTs with thiol-terminated organic molecules has also been demonstrated. Gold nanoparticles have been self-assembled at the surface of both amine- and thiol-functionalized boron nitride Nanotubes (BNNTs) in solution. This approach constitutes a basis for the preparation of highly functionalized BNNTs and for their utilization as nanoscale templates for assembly and integration with other nanoscale materials.

  13. Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Altman, Robin; Ly, Sonny; Hilt, Silvia; Petrlova, Jitka; Maezawa, Izumi; Kálai, Tamás; Hideg, Kálmán; Jin, Lee-Way; Laurence, Ted A.; Voss, John C.

    2015-12-01

    Alzheimer’s disease is characterized by the presence of extracellular plaques comprised of amyloid beta (Aβ) peptides. Soluble oligomers of the Aβ peptide underlie a cascade of neuronal loss and dysfunction associated with Alzheimer's disease. Single particle analyses of Aβ oligomers in solution by fluorescence correlation spectroscopy (FCS) were used to provide real-time descriptions of how spin-labeled fluorenes (SLFs; bi-functional small molecules that block the toxicity of Aβ) prevent and disrupt oligomeric assemblies of Aβ in solution. The FCS results, combined with electron paramagnetic resonance spectroscopy and circular dichroism spectroscopy, demonstrate SLFs can inhibit the growth of Aβ oligomers and disruptmore » existing oligomers while retaining Aβ in a largely disordered state. Furthermore, while the ability of SLF to block Aβ toxicity correlates with a reduction in oligomer size, our results suggest the conformation of Aβ within the oligomer determines the toxicity of the species. Attenuation of Aβ toxicity, which has been associated primarily with the soluble oligomeric form, can be achieved through redistribution of the peptides into smaller oligomers and arrest of the fractional increase in beta secondary structure.« less

  14. Portable Special Function Routines

    Energy Science and Technology Software Center (OSTI)

    1992-02-27

    SPECFUN is a collection of transportable FORTRAN subroutines and accompanying test drivers to evaluate certain special functions.

  15. STRUCTURAL STUDIES on SINGLE PARTICLES and BIOMOLECULES

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Univ., Portland, OR Pulmonary surfactant lowers surface tension in the alveoli of the lungs, preventing alveolar collapse and maintaining bronchial functionality. Two essential...

  16. Defect occurrence, detection, location and characterization; essential variables of the LBB concept application to primary piping

    SciTech Connect (OSTI)

    Crutzen, S.; Koble, T.D.; Lemaitre, P.

    1997-04-01

    Applications of the Leak Before Break (LBB) concept involve the knowledge of flaw presence and characteristics. In Service Inspection is given the responsibility of detecting flaws of a determined importance to locate them precisely and to classify them in broad families. Often LBB concepts application imply the knowledge of flaw characteristics such as through wall depth; length at the inner diameter (ID) or outer diameter (OD) surface; orientation or tilt and skew angles; branching; surface roughness; opening or width; crack tip aspect. Besides detection and characterization, LBB evaluations consider important the fact that a crack could be in the weld material or in the base material or in the heat affected zone. Cracks in tee junctions, in homogenous simple welds and in elbows are not considered in the same way. Essential variables of a flaw or defect are illustrated, and examples of flaws found in primary piping as reported by plant operators or service vendors are given. If such flaw variables are important in the applications of LBB concepts, essential is then the knowledge of the performance achievable by NDE techniques, during an ISI, in detecting such flaws, in locating them and in correctly evaluating their characteristics.

  17. Crystal Structure and Functional Analysis Identify Evolutionary Secret of

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SerRS in Vascular Development | Stanford Synchrotron Radiation Lightsource Crystal Structure and Functional Analysis Identify Evolutionary Secret of SerRS in Vascular Development Wednesday, July 31, 2013 Aminoacyl-tRNA synthetases (aaRS) have been essential enzymes for protein synthesis throughout evolution. As the tree of life was ascended, tRNA synthetases added new domains, which are generally dispensable for aminoacylation, in a progressive and accretive manner. The acquisitions were

  18. A Library of Basic System Functions

    Energy Science and Technology Software Center (OSTI)

    1995-06-01

    BASELIB is a support library for developing high-level library software. Its design is adaptable to other applications (utility routines, compilers, loaders, large application systems, etc.). BASELIB functions perform commonly-used system and I/O requests available in LTSS operating systems. BASELIB routines are machine dependent; they are closely tied to the machine and operating system for which they were programmed. However, an attempt was made to maintain compatibility and consistency across machines at the BASELIB calling levelmore » to provide a common base for moving large software systems across machines. It allows the programmer to structure higher level software in a machine independent fashion. Miscellaneous routines are included to perform character and string manipulation, number conversion, and output-file name generation.« less

  19. A Library of Basic System Functions

    Energy Science and Technology Software Center (OSTI)

    1995-06-01

    BASELIB is a support library for developing high-level library software. Its design is adaptable to other applications (utility routines, compilers, loaders, large application systems, etc.). BASELIB functions perform commonly-used system and I/O requests available in LTSS operating systems. BASELIB routines are machine-dependent; they are closely tied to the machine and operating system for which they were programmed. However, an attempt was made to maintain compatibility and consistency across machines at the BASELIB calling level tomore » provide a common base for moving large software systems across machines. It allows the programmer to structure higher-level software in a machine- independent fashion. Miscellaneous routines are included to perform character and string manipulation, number conversion, and output-file name generation.« less

  20. Stearoyl-CoA desaturase is an essential enzyme for the parasitic protist Trypanosoma brucei

    SciTech Connect (OSTI)

    Alloatti, Andres; Gupta, Shreedhara; Gualdron-Lopez, Melisa; Nguewa, Paul A.; Altabe, Silvia G.; Deumer, Gladys; Wallemacq, Pierre; Michels, Paul A.M.; Uttaro, Antonio D.

    2011-08-26

    Highlights: {yields} Inhibiting {Delta}9 desaturase drastically changes T. brucei's fatty-acid composition. {yields} Isoxyl specifically inhibits the {Delta}9 desaturase causing a growth arrest. {yields} RNA interference of desaturase expression causes a similar effect. {yields} Feeding T. brucei-infected mice with Isoxyl decreases the parasitemia. {yields} 70% of Isoxyl-treated mice survived the trypanosome infection. -- Abstract: Trypanosoma brucei, the etiologic agent of sleeping sickness, is exposed to important changes in nutrients and temperature during its life cycle. To adapt to these changes, the fluidity of its membranes plays a crucial role. This fluidity, mediated by the fatty-acid composition, is regulated by enzymes named desaturases. We have previously shown that the oleoyl desaturase is essential for Trypanosoma cruzi and T. brucei. In this work, we present experimental support for the relevance of stearoyl-CoA desaturase (SCD) for T. brucei's survival, in both its insect or procyclic-form (PCF) and bloodstream-form (BSF) stages. We evaluated this essentiality in two different ways: by generating a SCD knocked-down parasite line using RNA interference, and by chemical inhibition of the enzyme with two compounds, Isoxyl and a thiastearate with the sulfur atom at position 10 (10-TS). The effective concentration for 50% growth inhibition (EC{sub 50}) of PCF was 1.0 {+-} 0.2 {mu}M for Isoxyl and 5 {+-} 2 {mu}M for 10-TS, whereas BSF appeared more susceptible with EC{sub 50} values 0.10 {+-} 0.03 {mu}M (Isoxyl) and 1.0 {+-} 0.6 {mu}M (10-TS). RNA interference showed to be deleterious for both stages of the parasite. In addition, T. brucei-infected mice were fed with Isoxyl, causing a reduction of the parasitemia and an increase of the rodents' survival.

  1. Functionalized expanded porphyrins

    DOE Patents [OSTI]

    Sessler, Jonathan L; Pantos, Patricia J

    2013-11-12

    Disclosed are functionalized expanded porphyrins that can be used as spectrometric sensors for high-valent actinide cations. The disclosed functionalized expanded porphyrins have the advantage over unfunctionalized systems in that they can be immobilized via covalent attachment to a solid support comprising an inorganic or organic polymer or other common substrates. Substrates comprising the disclosed functionalized expanded porphyrins are also disclosed. Further, disclosed are methods of making the disclosed compounds (immobilized and free), methods of using them as sensors to detect high valent actinides, devices that comprise the disclosed compounds, and kits.

  2. Parametric Hazard Function Estimation.

    Energy Science and Technology Software Center (OSTI)

    1999-09-13

    Version 00 Phaze performs statistical inference calculations on a hazard function (also called a failure rate or intensity function) based on reported failure times of components that are repaired and restored to service. Three parametric models are allowed: the exponential, linear, and Weibull hazard models. The inference includes estimation (maximum likelihood estimators and confidence regions) of the parameters and of the hazard function itself, testing of hypotheses such as increasing failure rate, and checking ofmore » the model assumptions.« less

  3. Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences

    SciTech Connect (OSTI)

    Fox Iii, David N.; Le Trong, Isolde; Rajagopal, Ponni; Brzovic, Peter S.; Stenkamp, Ronald E.; Klevit, Rachel E.

    2008-07-25

    BARD1 is the constitutive nuclear partner to the breast and ovarian cancer specific tumor suppressor BRCA1. Together, they form a heterodimeric complex responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control.

  4. Maintainable substrate carrier for electroplating

    DOE Patents [OSTI]

    Chen, Chen-An; Abas, Emmanuel Chua; Divino, Edmundo Anida; Ermita, Jake Randal G.; Capulong, Jose Francisco S.; Castillo, Arnold Villamor; Ma; Diana Xiaobing

    2012-07-17

    One embodiment relates to a substrate carrier for use in electroplating a plurality of substrates. The carrier includes a non-conductive carrier body on which the substrates are placed and conductive lines embedded within the carrier body. A plurality of conductive clip attachment parts are attached in a permanent manner to the conductive lines embedded within the carrier body. A plurality of contact clips are attached in a removable manner to the clip attachment parts. The contact clips hold the substrates in place and conductively connecting the substrates with the conductive lines. Other embodiments, aspects and features are also disclosed.

  5. Maintaining a competitive geothermal industry

    SciTech Connect (OSTI)

    Zodiaco, V.P.

    1996-04-10

    I come to this geothermal business with over 30 years of experience in the power generation industry. I have earned my spurs (so to speak) in the electric utility, nuclear power, coal and the gas-fired cogeneration power businesses. I have been employed by Oxbow Power for the past seven years and for the past 18 months I have been based in Reno and responsible for the operation, maintenance and management of Oxbow`s domestic power projects which include three geothermal and two gas-fired facilities. The Oxbow Power Group (consisting principally of Oxbow Power Corporation, Oxbow Geothermal Corporation, Oxbow Power of Beowawe, Oxbow Power International and Oxbow Power Services, Inc.) is based in West Palm Beach, Florida, and has regional offices in Reno, Hong Kong and Manila to support on-line geothermal projects in Nevada, other domestic power projects and a geothermal plant under construction in the Philippines. Oxbow Power employs approximately 30 professionals in the development and management of power projects and over 100 supervisors and technicians in the operation and maintenance of power facilities. Current ownership in independent power projects total 340 MW in the United States and 47 MW under construction in the Philippines. Oxbow is currently negotiating additional projects in several Asian and Central American countries.

  6. Center for Functional Nanomaterials

    ScienceCinema (OSTI)

    BNL

    2009-09-01

    Staff from Brookhaven's new Center for Functional Nanomaterials (CFN) describe how this advanced facility will focus on the development and understanding of nanoscale materials. The CFN provides state-of-the-art capabilities for the fabrication and study of nanoscale materials, with an emphasis on atomic-level tailoring to achieve desired properties and functions. The overarching scientific theme of the CFN is the development and understanding of nanoscale materials that address the Nation's challenges in energy security.

  7. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Extracting the Eliashberg Function Print Wednesday, 23 February 2005 00:00 A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these

  8. Structure function monitor

    DOE Patents [OSTI]

    McGraw, John T.; Zimmer, Peter C.; Ackermann, Mark R.

    2012-01-24

    Methods and apparatus for a structure function monitor provide for generation of parameters characterizing a refractive medium. In an embodiment, a structure function monitor acquires images of a pupil plane and an image plane and, from these images, retrieves the phase over an aperture, unwraps the retrieved phase, and analyzes the unwrapped retrieved phase. In an embodiment, analysis yields atmospheric parameters measured at spatial scales from zero to the diameter of a telescope used to collect light from a source.

  9. Aging assessment of essential HVAC chillers used in nuclear power plants. Phase 1, Volume 1

    SciTech Connect (OSTI)

    Blahnik, D.E.; Klein, R.F.

    1993-09-01

    The Pacific Northwest Laboratory conducted a Phase I aging assessment of chillers used in the essential safety air-conditioning systems of nuclear power plants. Centrifugal chillers in the 75- to 750-ton refrigeration capacity range are the predominant type used. The chillers used, and air-conditioning systems served, vary in design from plant-to-plant. It is crucial to keep chiller internals very clean and to prevent the leakage of water, air, and other contaminants into the refrigerant containment system. Periodic operation on a weekly or monthly basis is necessary to remove moisture and noncondensable gases that gradually build up inside the chiller. This is especially desirable if a chiller is required to operate only as an emergency standby unit. The primary stressors and aging mechanisms that affect chillers include vibration, excessive temperatures and pressures, thermal cycling, chemical attack, and poor quality cooling water. Aging is accelerated by moisture, non-condensable gases (e.g., air), dirt, and other contamination within the refrigerant containment system, excessive start/stop cycling, and operating below the rated capacity. Aging is also accelerated by corrosion and fouling of the condenser and evaporator tubes. The principal cause of chiller failures is lack of adequate monitoring. Lack of performing scheduled maintenance and human errors also contribute to failures.

  10. Two Translation Products of Yersinia yscQ Assemble To Form a Complex Essential to Type III Secretion

    SciTech Connect (OSTI)

    Bzymek, Krzysztof P.; Hamaoka, Brent Y.; Ghosh, Partho

    2012-07-11

    The bacterial flagellar C-ring is composed of two essential proteins, FliM and FliN. The smaller protein, FliN, is similar to the C-terminus of the larger protein, FliM, both being composed of SpoA domains. While bacterial type III secretion (T3S) systems encode many proteins in common with the flagellum, they mostly have a single protein in place of FliM and FliN. This protein resembles FliM at its N-terminus and is as large as FliM but is more like FliN at its C-terminal SpoA domain. We have discovered that a FliN-sized cognate indeed exists in the Yersinia T3S system to accompany the FliM-sized cognate. The FliN-sized cognate, YscQ-C, is the product of an internal translation initiation site within the locus encoding the FliM-sized cognate YscQ. Both intact YscQ and YscQ-C were found to be required for T3S, indicating that the internal translation initiation site, which is conserved in some but not all YscQ orthologs, is crucial for function. The crystal structure of YscQ-C revealed a SpoA domain that forms a highly intertwined, domain-swapped homodimer, similar to those observed in FliN and the YscQ ortholog HrcQ{sub B}. A single YscQ-C homodimer associated reversibly with a single molecule of intact YscQ, indicating conformational differences between the SpoA domains of intact YscQ and YscQ-C. A 'snap-back' mechanism suggested by the structure can account for this. The 1:2 YscQ-YscQ-C complex is a close mimic of the 1:4 FliM-FliN complex and the likely building block of the putative Yersinia T3S system C-ring.

  11. Algal functional annotation tool

    SciTech Connect (OSTI)

    Lopez, D.; Casero, D.; Cokus, S. J.; Merchant, S. S.; Pellegrini, M.

    2012-07-01

    The Algal Functional Annotation Tool is a web-based comprehensive analysis suite integrating annotation data from several pathway, ontology, and protein family databases. The current version provides annotation for the model alga Chlamydomonas reinhardtii, and in the future will include additional genomes. The site allows users to interpret large gene lists by identifying associated functional terms, and their enrichment. Additionally, expression data for several experimental conditions were compiled and analyzed to provide an expression-based enrichment search. A tool to search for functionally-related genes based on gene expression across these conditions is also provided. Other features include dynamic visualization of genes on KEGG pathway maps and batch gene identifier conversion.

  12. Adaptive multiconfigurational wave functions

    SciTech Connect (OSTI)

    Evangelista, Francesco A.

    2014-03-28

    A method is suggested to build simple multiconfigurational wave functions specified uniquely by an energy cutoff ?. These are constructed from a model space containing determinants with energy relative to that of the most stable determinant no greater than ?. The resulting ?-CI wave function is adaptive, being able to represent both single-reference and multireference electronic states. We also consider a more compact wave function parameterization (?+SD-CI), which is based on a small ?-CI reference and adds a selection of all the singly and doubly excited determinants generated from it. We report two heuristic algorithms to build ?-CI wave functions. The first is based on an approximate prescreening of the full configuration interaction space, while the second performs a breadth-first search coupled with pruning. The ?-CI and ?+SD-CI approaches are used to compute the dissociation curve of N{sub 2} and the potential energy curves for the first three singlet states of C{sub 2}. Special attention is paid to the issue of energy discontinuities caused by changes in the size of the ?-CI wave function along the potential energy curve. This problem is shown to be solvable by smoothing the matrix elements of the Hamiltonian. Our last example, involving the Cu{sub 2}O{sub 2}{sup 2+} core, illustrates an alternative use of the ?-CI method: as a tool to both estimate the multireference character of a wave function and to create a compact model space to be used in subsequent high-level multireference coupled cluster computations.

  13. Algal functional annotation tool

    SciTech Connect (OSTI)

    2012-07-12

    Abstract BACKGROUND: Progress in genome sequencing is proceeding at an exponential pace, and several new algal genomes are becoming available every year. One of the challenges facing the community is the association of protein sequences encoded in the genomes with biological function. While most genome assembly projects generate annotations for predicted protein sequences, they are usually limited and integrate functional terms from a limited number of databases. Another challenge is the use of annotations to interpret large lists of 'interesting' genes generated by genome-scale datasets. Previously, these gene lists had to be analyzed across several independent biological databases, often on a gene-by-gene basis. In contrast, several annotation databases, such as DAVID, integrate data from multiple functional databases and reveal underlying biological themes of large gene lists. While several such databases have been constructed for animals, none is currently available for the study of algae. Due to renewed interest in algae as potential sources of biofuels and the emergence of multiple algal genome sequences, a significant need has arisen for such a database to process the growing compendiums of algal genomic data. DESCRIPTION: The Algal Functional Annotation Tool is a web-based comprehensive analysis suite integrating annotation data from several pathway, ontology, and protein family databases. The current version provides annotation for the model alga Chlamydomonas reinhardtii, and in the future will include additional genomes. The site allows users to interpret large gene lists by identifying associated functional terms, and their enrichment. Additionally, expression data for several experimental conditions were compiled and analyzed to provide an expression-based enrichment search. A tool to search for functionally-related genes based on gene expression across these conditions is also provided. Other features include dynamic visualization of genes on KEGG

  14. Algal functional annotation tool

    Energy Science and Technology Software Center (OSTI)

    2012-07-12

    Abstract BACKGROUND: Progress in genome sequencing is proceeding at an exponential pace, and several new algal genomes are becoming available every year. One of the challenges facing the community is the association of protein sequences encoded in the genomes with biological function. While most genome assembly projects generate annotations for predicted protein sequences, they are usually limited and integrate functional terms from a limited number of databases. Another challenge is the use of annotations tomore » interpret large lists of 'interesting' genes generated by genome-scale datasets. Previously, these gene lists had to be analyzed across several independent biological databases, often on a gene-by-gene basis. In contrast, several annotation databases, such as DAVID, integrate data from multiple functional databases and reveal underlying biological themes of large gene lists. While several such databases have been constructed for animals, none is currently available for the study of algae. Due to renewed interest in algae as potential sources of biofuels and the emergence of multiple algal genome sequences, a significant need has arisen for such a database to process the growing compendiums of algal genomic data. DESCRIPTION: The Algal Functional Annotation Tool is a web-based comprehensive analysis suite integrating annotation data from several pathway, ontology, and protein family databases. The current version provides annotation for the model alga Chlamydomonas reinhardtii, and in the future will include additional genomes. The site allows users to interpret large gene lists by identifying associated functional terms, and their enrichment. Additionally, expression data for several experimental conditions were compiled and analyzed to provide an expression-based enrichment search. A tool to search for functionally-related genes based on gene expression across these conditions is also provided. Other features include dynamic visualization of genes on

  15. GADRAS Detector Response Function.

    SciTech Connect (OSTI)

    Mitchell, Dean J.; Harding, Lee; Thoreson, Gregory G; Horne, Steven M.

    2014-11-01

    The Gamma Detector Response and Analysis Software (GADRAS) applies a Detector Response Function (DRF) to compute the output of gamma-ray and neutron detectors when they are exposed to radiation sources. The DRF is fundamental to the ability to perform forward calculations (i.e., computation of the response of a detector to a known source), as well as the ability to analyze spectra to deduce the types and quantities of radioactive material to which the detectors are exposed. This document describes how gamma-ray spectra are computed and the significance of response function parameters that define characteristics of particular detectors.

  16. Aging assessment of essential HVAC chillers used in nuclear power plants

    SciTech Connect (OSTI)

    Blahnik, D.E.; Camp, T.W.

    1996-09-01

    The Pacific Northwest Laboratory conducted a comprehensive aging assessment of chillers used in the essential safety air-conditioning systems in nuclear power plants (NPPs). The chillers used, and air-conditioning systems served, vary in design from plant to plant. The review of operating experience indicated that chillers experience aging degradation and failures. The primary aging factors of concern for chillers include vibration, excessive temperatures and pressures, thermal cycling, chemical attack, and poor quality cooling water. The evaluation of Licensee Event Reports (LERs) indicated that about 38% of the failures were primarily related to aging, 55% were partially aging related, and 7% of the failures were unassignable. About 25% of the failures were primarily caused by human, design, procedure, and other errors. The large number of errors is probably directly related to the complexity of chillers and their interfacing systems. Nearly all of the LERs were the result of entering plant Technical Specification Limiting Condition for Operation (LCO) that initiated remedial actions like plant shutdown procedures. The trend for chiller-related LERs has stabilized at about 0.13 LERs per plant year since 1988. Carefully following the vendor procedures and monitoring the equipment can help to minimize and/or eliminate most of the premature failures. Recording equipment performance can be useful for trending analysis. Periodic operation for a few hours on a weekly or monthly basis is useful to remove moisture and non-condensable gases that gradually build up inside the chiller. Chiller pressurization kits are available that will help minimize the amount of moisture and air ingress to low-pressure chillers during standby periods. The assessment of service life condition monitoring of chillers indicated there are many simple to sophisticated methods available that can help in chiller surveillance and monitoring.

  17. Process for functionalizing alkanes

    DOE Patents [OSTI]

    Bergman, R.G.; Janowicz, A.H.; Periana, R.A.

    1988-05-24

    Process for functionalizing saturated hydrocarbons comprises: (a) reacting said saturated hydrocarbons of the formula: R[sub 1]H wherein H represents a hydrogen atom; and R[sub 1] represents a saturated hydrocarbon radical, with a metal complex of the formula: CpRh[P(R[sub 2])[sub 3

  18. Repetition frequency scaling of an all-polarization maintaining erbium-doped mode-locked fiber laser based on carbon nanotubes saturable absorber

    SciTech Connect (OSTI)

    Sotor, J. Sobon, G.; Abramski, K. M.; Jagiello, J.; Lipinska, L.

    2015-04-07

    We demonstrate an all-polarization maintaining (PM), mode-locked erbium (Er)-doped fiber laser based on a carbon nanotubes (CNT) saturable absorber (SA). The laser resonator was maximally simplified by using only one passive hybrid component and a pair of fiber connectors with deposited CNTs. The repetition frequency (F{sub rep}) of such a cost-effective and self-starting mode-locked laser was scaled from 54.3 MHz to 358.6 MHz. The highest F{sub rep} was obtained when the total cavity length was shortened to 57 cm. The laser allows ultrashort pulse generation with the duration ranging from 240 fs to 550 fs. Because the laser components were based on PM fibers the laser was immune to the external perturbations and generated laniary polarized light with the degree of polarization (DOP) of 98.7%.

  19. Resizing the conformal window: A {beta}-function ansatz

    SciTech Connect (OSTI)

    Antipin, O.; Tuominen, K.

    2010-04-01

    We propose an ansatz for the nonperturbative beta-function of a generic nonsupersymmetric Yang-Mills theory with or without fermions in an arbitrary representation of the gauge group. While our construction is similar to the recently proposed Ryttov-Sannino all-order beta-function, the essential difference is that it allows for the existence of an unstable ultraviolet fixed point in addition to the predicted Banks-Zaks-like infrared stable fixed point. Our beta-function preserves all of the tested features with respect to the nonsupersymmetric Yang-Mills theories. We predict the conformal window identifying the lower end of it as a merger of the infrared and ultraviolet fixed points.

  20. Process for functionalizing alkanes

    DOE Patents [OSTI]

    Bergman, R.G.; Janowicz, A.H.; Periana-Pillai, R.A.

    1984-06-12

    Process for functionalizing saturated hydrocarbons selectively in the terminal position comprises: (a) reacting said saturated hydrocarbons with a metal complex CpRhPMe/sub 3/H/sub 2/ in the presence of ultraviolet radiation at -60/sup 0/ to -17/sup 0/C to form a hydridoalkyl complex CpRhPMe/sub 3/RH; (b) reacting said hydridoalkyl complex with a haloform CHX/sub 3/ at -60/sup 0/ to -17/sup 0/C to form the corresponding haloalkyl complex of step (a) CpRhPMe/sub 3/RX; and (c) reacting said haloalkyl complex with halogen -60 to 25/sup 0/C to form a functional haloalkyl compound.

  1. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  2. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  3. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  4. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  5. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  6. Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Burstein, David; Sun, Christine L.; Brown, Christopher T.; Sharon, Itai; Anantharaman, Karthik; Probst, Alexander J.; Thomas, Brian C.; Banfield, Jillian F.

    2016-02-03

    Here, current understanding of microorganism–virus interactions, which shape the evolution and functioning of Earth’s ecosystems, is based primarily on cultivated organisms. Here we investigate thousands of viral and microbial genomes recovered using a cultivation independent approach to study the frequency, variety and taxonomic distribution of viral defence mechanisms. CRISPR-Cas systems that confer microorganisms with immunity to viruses are present in only 10% of 1,724 sampled microorganisms, compared with previous reports of 40% occurrence in bacteria and 81% in archaea. We attribute this large difference to the lack of CRISPR-Cas systems across major bacterial lineages that have no cultivated representatives. Wemore » correlate absence of CRISPR-Cas with lack of nucleotide biosynthesis capacity and a symbiotic lifestyle. Restriction systems are well represented in these lineages and might provide both non-specific viral defence and access to nucleotides.« less

  7. Development and Clinical Implementation of a Universal Bolus to Maintain Spot Size During Delivery of Base of Skull Pencil Beam Scanning Proton Therapy

    SciTech Connect (OSTI)

    Both, Stefan; Shen, Jiajian; Kirk, Maura; Lin, Liyong; Tang, Shikui; Alonso-Basanta, Michelle; Lustig, Robert; Lin, Haibo; Deville, Curtiland; Hill-Kayser, Christine; Tochner, Zelig; McDonough, James

    2014-09-01

    Purpose: To report on a universal bolus (UB) designed to replace the range shifter (RS); the UB allows the treatment of shallow tumors while keeping the pencil beam scanning (PBS) spot size small. Methods and Materials: Ten patients with brain cancers treated from 2010 to 2011 were planned using the PBS technique with bolus and the RS. In-air spot sizes of the pencil beam were measured and compared for 4 conditions (open field, with RS, and with UB at 2- and 8-cm air gap) in isocentric geometry. The UB was applied in our clinic to treat brain tumors, and the plans with UB were compared with the plans with RS. Results: A UB of 5.5 cm water equivalent thickness was found to meet the needs of the majority of patients. By using the UB, the PBS spot sizes are similar with the open beam (P>.1). The heterogeneity index was found to be approximately 10% lower for the UB plans than for the RS plans. The coverage for plans with UB is more conformal than for plans with RS; the largest increase in sparing is usually for peripheral organs at risk. Conclusions: The integrity of the physical properties of the PBS beam can be maintained using a UB that allows for highly conformal PBS treatment design, even in a simple geometry of the fixed beam line when noncoplanar beams are used.

  8. Policy Flash 2013-40 Acquisition Guide Chapter 43.3 Maintaining Alignment of Project Management with Contract Management of Non-Management and Operating (M&O) Cost Reimburstment Contracts

    Broader source: Energy.gov [DOE]

    Attached is Policy Flash 2013-40 Acquisition Guide Chapter 43.3 Maintaining Alignment of Project Management with Contract Management of Non-Management and Operating (M&O) Cost Reimbursement...

  9. Process for functionalizing alkanes

    DOE Patents [OSTI]

    Bergman, Robert G.; Janowicz, Andrew H.; Periana, Roy A.

    1988-01-01

    Process for functionalizing saturated hydrocarbons comprising: (a) reacting said saturated hydrocarbons of the formula: R.sub.1 H wherein H represents a hydrogen atom; and R.sub.1 represents a saturated hydrocarbon radical, with a metal complex of the formula: CpRh[P(R.sub.2).sub.3 ]H.sub.2 wherein Cp represents a cyclopentadienyl or alkylcyclopentadienyl radical; Rh represents a rhodium atom; P represents a phosphorus atom; R.sub.2 represents a hydrocarbon radical; H represents a hydrogen atom, in the presence of ultraviolet radiation to form a hydridoalkyl complex of the formula: CpRh[P(R.sub.2).sub.3 ](R.sub.1)H (b) reacting said hydridoalkyl complex with an organic halogenating agent such as a tetrahalomethane or a haloform of the formulas: CX'X''X'''X'''' or CHX'X''X''' wherein X', X'', X'", X"" represent halogens selected from bromine, iodine or chlorine atom, at a temperature in the range of about -60.degree. to -17.degree. C. to form the corresponding haloalkyl complex of step (a) having the formula: CpRhPMe.sub.3 RX; and, (c) reacting said haloalkyl complex formed in (b) with halogen (X.sub.2) at a temperature in the range of about -60.degree. to 25.degree. C. (i.e., ambient) to form a functional haloalkyl compound.

  10. Adapting ORAP to wind plants : industry value and functional requirements.

    SciTech Connect (OSTI)

    Not Available

    2010-08-01

    Strategic Power Systems (SPS) was contracted by Sandia National Laboratories to assess the feasibility of adapting their ORAP (Operational Reliability Analysis Program) tool for deployment to the wind industry. ORAP for Wind is proposed for use as the primary data source for the CREW (Continuous Reliability Enhancement for Wind) database which will be maintained by Sandia to enable reliability analysis of US wind fleet operations. The report primarily addresses the functional requirements of the wind-based system. The SPS ORAP reliability monitoring system has been used successfully for over twenty years to collect RAM (Reliability, Availability, Maintainability) and operations data for benchmarking and analysis of gas and steam turbine performance. This report documents the requirements to adapt the ORAP system for the wind industry. It specifies which existing ORAP design features should be retained, as well as key new requirements for wind. The latter includes alignment with existing and emerging wind industry standards (IEEE 762, ISO 3977 and IEC 61400). There is also a comprehensive list of thirty critical-to-quality (CTQ) functional requirements which must be considered and addressed to establish the optimum design for wind.

  11. Next Generation Nuclear Plant Resilient Control System Functional Analysis

    SciTech Connect (OSTI)

    Lynne M. Stevens

    2010-07-01

    Control Systems and their associated instrumentation must meet reliability, availability, maintainability, and resiliency criteria in order for high temperature gas-cooled reactors (HTGRs) to be economically competitive. Research, perhaps requiring several years, may be needed to develop control systems to support plant availability and resiliency. This report functionally analyzes the gaps between traditional and resilient control systems as applicable to HTGRs, which includes the Next Generation Nuclear Plant; defines resilient controls; assesses the current state of both traditional and resilient control systems; and documents the functional gaps existing between these two controls approaches as applicable to HTGRs. This report supports the development of an overall strategy for applying resilient controls to HTGRs by showing that control systems with adequate levels of resilience perform at higher levels, respond more quickly to disturbances, increase operational efficiency, and increase public protection.

  12. The N-terminal leucine-zipper motif in PTRF/cavin-1 is essential and sufficient for its caveolae-association

    SciTech Connect (OSTI)

    Wei, Zhuang; Zou, Xinle; Wang, Hongzhong; Lei, Jigang; Wu, Yuan; Liao, Kan

    2015-01-16

    Highlight: • The N-terminal leucine-zipper motif in PTRF/cavin-1 determines caveolar association. • Different cellular localization of PTRF/cavin-1 influences its serine 389 and 391 phosphorylation state. • PTRF/cavin-1 regulates cell motility via its caveolar association. - Abstract: PTRF/cavin-1 is a protein of two lives. Its reported functions in ribosomal RNA synthesis and in caveolae formation happen in two different cellular locations: nucleus vs. plasma membrane. Here, we identified that the N-terminal leucine-zipper motif in PTRF/cavin-1 was essential for the protein to be associated with caveolae in plasma membrane. It could counteract the effect of nuclear localization sequence in the molecule (AA 235–251). Deletion of this leucine-zipper motif from PTRF/cavin-1 caused the mutant to be exclusively localized in nuclei. The fusion of this leucine-zipper motif with histone 2A, which is a nuclear protein, could induce the fusion protein to be exported from nucleus. Cell migration was greatly inhibited in PTRF/cavin-1{sup −/−} mouse embryonic fibroblasts (MEFs). The inhibited cell motility could only be rescued by exogenous cavin-1 but not the leucine-zipper motif deleted cavin-1 mutant. Plasma membrane dynamics is an important factor in cell motility control. Our results suggested that the membrane dynamics in cell migration is affected by caveolae associated PTRF/cavin-1.

  13. Process management using component thermal-hydraulic function classes

    DOE Patents [OSTI]

    Morman, J.A.; Wei, T.Y.C.; Reifman, J.

    1999-07-27

    A process management expert system where following malfunctioning of a component, such as a pump, for determining system realignment procedures such as for by-passing the malfunctioning component with on-line speeds to maintain operation of the process at full or partial capacity or to provide safe shut down of the system while isolating the malfunctioning component. The expert system uses thermal-hydraulic function classes at the component level for analyzing unanticipated as well as anticipated component malfunctions to provide recommended sequences of operator actions. Each component is classified according to its thermal-hydraulic function, and the generic and component-specific characteristics for that function. Using the diagnosis of the malfunctioning component and its thermal hydraulic class, the expert system analysis is carried out using generic thermal-hydraulic first principles. One aspect of the invention employs a qualitative physics-based forward search directed primarily downstream from the malfunctioning component in combination with a subsequent backward search directed primarily upstream from the serviced component. Generic classes of components are defined in the knowledge base according to the three thermal-hydraulic functions of mass, momentum and energy transfer and are used to determine possible realignment of component configurations in response to thermal-hydraulic function imbalance caused by the malfunctioning component. Each realignment to a new configuration produces the accompanying sequence of recommended operator actions. All possible new configurations are examined and a prioritized list of acceptable solutions is produced. 5 figs.

  14. Process management using component thermal-hydraulic function classes

    DOE Patents [OSTI]

    Morman, James A.; Wei, Thomas Y. C.; Reifman, Jaques

    1999-01-01

    A process management expert system where following malfunctioning of a component, such as a pump, for determining system realignment procedures such as for by-passing the malfunctioning component with on-line speeds to maintain operation of the process at full or partial capacity or to provide safe shut down of the system while isolating the malfunctioning component. The expert system uses thermal-hydraulic function classes at the component level for analyzing unanticipated as well as anticipated component malfunctions to provide recommended sequences of operator actions. Each component is classified according to its thermal-hydraulic function, and the generic and component-specific characteristics for that function. Using the diagnosis of the malfunctioning component and its thermal hydraulic class, the expert system analysis is carried out using generic thermal-hydraulic first principles. One aspect of the invention employs a qualitative physics-based forward search directed primarily downstream from the malfunctioning component in combination with a subsequent backward search directed primarily upstream from the serviced component. Generic classes of components are defined in the knowledge base according to the three thermal-hydraulic functions of mass, momentum and energy transfer and are used to determine possible realignment of component configurations in response to thermal-hydraulic function imbalance caused by the malfunctioning component. Each realignment to a new configuration produces the accompanying sequence of recommended operator actions. All possible new configurations are examined and a prioritized list of acceptable solutions is produced.

  15. Structure-Assisted Functional Anchor Implantation in Robust Metal-Organic Frameworks with Ultra large Pores

    SciTech Connect (OSTI)

    Park, J; Feng, DW; Zhou, HC

    2015-02-04

    A facile functionalization assisted by the structural attributes of PCN-333 has been studied while maintaining the integrity of the parent MOF including ultralarge pores, chemical robustness, and crystallinity. Herein we thoroughly analyzed ligand exchange phenomena in PCN-333 and demonstrate that the extent of exchange can be tailored by varying the exchange conditions as potential applications may require. Through this method a variety of functional groups are incorporated into PCN-333. To further show the capabilities of this system introduction of a BODIPY fluorophore as a secondary functionality was performed to the functionalized framework via a click reaction. We anticipate the PCN-333 with functional anchor can serve as a stable platform for further chemistry to be explored in future applications

  16. Structure-Assisted Functional Anchor Implantation in Robust Metal–Organic Frameworks with Ultralarge Pores

    SciTech Connect (OSTI)

    Park, Jihye; Feng, Dawei; Zhou, Hong-Cai

    2015-02-04

    A facile functionalization assisted by the structural attributes of PCN-333 has been studied while maintaining the integrity of the parent MOF including ultralarge pores, chemical robustness, and crystallinity. Herein we thoroughly analyzed ligand exchange phenomena in PCN-333 and demonstrate that the extent of exchange can be tailored by varying the exchange conditions as potential applications may require. Through this method a variety of functional groups are incorporated into PCN-333. To further show the capabilities of this system introduction of a BODIPY fluorophore as a secondary functionality was performed to the functionalized framework via a click reaction. We anticipate the PCN-333 with functional anchor can serve as a stable platform for further chemistry to be explored in future applications.

  17. Computing Legacy Software Behavior to Understand Functionality and Security Properties: An IBM/370 Demonstration

    SciTech Connect (OSTI)

    Linger, Richard C; Pleszkoch, Mark G; Prowell, Stacy J; Sayre, Kirk D; Ankrum, Scott

    2013-01-01

    Organizations maintaining mainframe legacy software can benefit from code modernization and incorporation of security capabilities to address the current threat environment. Oak Ridge National Laboratory is developing the Hyperion system to compute the behavior of software as a means to gain understanding of software functionality and security properties. Computation of functionality is critical to revealing security attributes, which are in fact specialized functional behaviors of software. Oak Ridge is collaborating with MITRE Corporation to conduct a demonstration project to compute behavior of legacy IBM Assembly Language code for a federal agency. The ultimate goal is to understand functionality and security vulnerabilities as a basis for code modernization. This paper reports on the first phase, to define functional semantics for IBM Assembly instructions and conduct behavior computation experiments.

  18. FFTF Plant transition function analysis report

    SciTech Connect (OSTI)

    Lund, D.P.; FFTF Working Group

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and function hierarchy charts that describe what needs to be performed to deactivate FFTF.

  19. Methods of making functionalized nanorods

    DOE Patents [OSTI]

    Gur, Ilan; Milliron, Delia; Alivisatos, A. Paul; Liu, Haitao

    2012-01-10

    A process for forming functionalized nanorods. The process includes providing a substrate, modifying the substrate by depositing a self-assembled monolayer of a bi-functional molecule on the substrate, wherein the monolayer is chosen such that one side of the bi-functional molecule binds to the substrate surface and the other side shows an independent affinity for binding to a nanocrystal surface, so as to form a modified substrate. The process further includes contacting the modified substrate with a solution containing nanocrystal colloids, forming a bound monolayer of nanocrystals on the substrate surface, depositing a polymer layer over the monolayer of nanocrystals to partially cover the monolayer of nanocrystals, so as to leave a layer of exposed nanocrystals, functionalizing the exposed nanocrystals, to form functionalized nanocrystals, and then releasing the functionalized nanocrystals from the substrate.

  20. Functional Accountability | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    The Office of the Chief Human Capital Officer exercises functional accountability over human resources authorities and human capital programs. This ensures the Department's ...

  1. Dual function conducting polymer diodes

    DOE Patents [OSTI]

    Heeger, Alan J.; Yu, Gang

    1996-01-01

    Dual function diodes based on conjugated organic polymer active layers are disclosed. When positively biased the diodes function as light emitters. When negatively biased they are highly efficient photodiodes. Methods of preparation and use of these diodes in displays and input/output devices are also disclosed.

  2. Multi-functional composite structures

    DOE Patents [OSTI]

    Mulligan, Anthony C.; Halloran, John; Popovich, Dragan; Rigali, Mark J.; Sutaria, Manish P.; Vaidyanathan, K. Ranji; Fulcher, Michael L.; Knittel, Kenneth L.

    2010-04-27

    Fibrous monolith processing techniques to fabricate multifunctional structures capable of performing more than one discrete function such as structures capable of bearing structural loads and mechanical stresses in service and also capable of performing at least one additional non-structural function.

  3. Multi-functional composite structures

    DOE Patents [OSTI]

    Mulligan, Anthony C.; Halloran, John; Popovich, Dragan; Rigali, Mark J.; Sutaria, Manish P.; Vaidyanathan, K. Ranji; Fulcher, Michael L.; Knittel, Kenneth L.

    2004-10-19

    Fibrous monolith processing techniques to fabricate multifunctional structures capable of performing more than one discrete function such as structures capable of bearing structural loads and mechanical stresses in service and also capable of performing at least one additional non-structural function.

  4. High-Level Functional and Operational Requirements for the Advanced Fuel Cycle Facilty

    SciTech Connect (OSTI)

    Charles Park

    2006-12-01

    High-Level Functional & Operational Requirements for the AFCF -This document describes the principal functional and operational requirements for the proposed Advanced Fuel Cycle Facility (AFCF). The AFCF is intended to be the world's foremost facility for nuclear fuel cycle research, technology development, and demonstration. The facility will also support the near-term mission to develop and demonstrate technology in support of fuel cycle needs identified by industry, and the long-term mission to retain and retain U.S. leadership in fuel cycle operations. The AFCF is essential to demonstrate a more proliferation-resistant fuel cycle and make long-term improvements in fuel cycle effectiveness, performance and economy.

  5. Comparative proteome approach demonstrates that platelet-derived growth factor C and D efficiently induce proliferation while maintaining multipotency of hMSCs

    SciTech Connect (OSTI)

    Sotoca, Ana M.; Roelofs-Hendriks, Jose; Boeren, Sjef; Kraan, Peter M. van der; Vervoort, Jacques; Zoelen, Everardus J.J. van; Piek, Ester

    2013-10-15

    This is the first study that comprehensively describes the effects of the platelet-derived growth factor (PDGF) isoforms C and D during in vitro expansion of human mesenchymal stem cells (hMSCs). Our results show that PDGFs can enhance proliferation of hMSCs without affecting their multipotency. It is of great value to culture and expand hMSCs in a safe and effective manner without losing their multipotency for manipulation and further development of cell-based therapies. Moreover, differential effects of PDGF isoforms have been observed on lineage-specific differentiation induced by BMP2 and Vitamin D3. Based on label-free LC-based quantitative proteomics approach we have furthermore identified specific pathways induced by PDGFs during the proliferation process, showing the importance of bioinformatics tools to study cell function. - Highlights: • PDGFs (C and D) significantly increased the number of multipotent undifferentiated hMSCs. • Enhanced proliferation did not impair the ability to undergo lineage-specific differentiation. • Proteomic analysis confirmed the overall signatures of the ‘intact’ cells.

  6. Sustainable Energy Solutions Task 2.0: Wind Turbine Reliability and Maintainability Enhancement through System-wide Structure Health Monitoring and Modifications to Rotating Components

    SciTech Connect (OSTI)

    Janet M Twomey, PhD

    2010-04-30

    EXECUTIVE SUMARRY An evaluation of nondestructive structural health monitoring methods was completed with over 132 documents, 37 specifically about wind turbines, summarized into a technology matrix. This matrix lists the technology, what can be monitored with this technology, and gives a short summary of the key aspects of the technology and its application. Passive and active acoustic emission equipment from Physical Acoustics Corp. and Acellent Technologies have been evaluated and selected for use in experimental state loading and fatigue tests of composite wind turbine blade materials. Acoustic Emission (AE) and Active Ultrasonic Testing (AUT), were applied to composite coupons with both simulated and actual damage. The results found that, while composites are more complicated in nature, compared to metallic structures, an artificial neural network analysis could still be used to determine damage. For the AE system, the failure mode could be determined (i.e. fiber breakage, delamination, etc.). The Acellent system has been evaluated to work well with composite materials. A test-rig for reliability testing of the rotating components was constructed. The research on the types of bearings used in the wind turbines indicated that in most of the designs, the main bearings utilized to support the shaft are cylindrical roller bearings. The accelerated degradation testing of a population of bearings was performed. Vibration and acoustic emission data was collected and analyzed in order to identify a representative degradation signal for each bearing to identify the initiation of the degradation process in the bearings. Afterwards, the RMS of the vibration signal from degradation initiation up to the end of the useful life of the bearing was selected to predict the remaining useful life of the bearing. This step included fitting Autoregressive Moving Average (ARMA) models to the degradation signals and approximating the probability distribution function (PDF) of

  7. Automatic computation of transfer functions

    DOE Patents [OSTI]

    Atcitty, Stanley; Watson, Luke Dale

    2015-04-14

    Technologies pertaining to the automatic computation of transfer functions for a physical system are described herein. The physical system is one of an electrical system, a mechanical system, an electromechanical system, an electrochemical system, or an electromagnetic system. A netlist in the form of a matrix comprises data that is indicative of elements in the physical system, values for the elements in the physical system, and structure of the physical system. Transfer functions for the physical system are computed based upon the netlist.

  8. Functionalized magnetic nanoparticle analyte sensor

    DOE Patents [OSTI]

    Yantasee, Wassana; Warner, Maryin G; Warner, Cynthia L; Addleman, Raymond S; Fryxell, Glen E; Timchalk, Charles; Toloczko, Mychailo B

    2014-03-25

    A method and system for simply and efficiently determining quantities of a preselected material in a particular solution by the placement of at least one superparamagnetic nanoparticle having a specified functionalized organic material connected thereto into a particular sample solution, wherein preselected analytes attach to the functionalized organic groups, these superparamagnetic nanoparticles are then collected at a collection site and analyzed for the presence of a particular analyte.

  9. Precision linear ramp function generator

    DOE Patents [OSTI]

    Jatko, W.B.; McNeilly, D.R.; Thacker, L.H.

    1984-08-01

    A ramp function generator is provided which produces a precise linear ramp function which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

  10. Recovery of essential nutrients from municipal solid waste – Impact of waste management infrastructure and governance aspects

    SciTech Connect (OSTI)

    Zabaleta, Imanol; Rodic, Ljiljana

    2015-10-15

    Every year 120–140 million tonnes of bio-waste are generated in Europe, most of which is landfilled, incinerated or stabilized and used as covering material in landfill operation. None of these practices enables the recovery of essential nutrients such as phosphorus (P) and nitrogen (N), which are in great demand for agricultural production. Recovery of these nutrients is a matter of international concern considering the non-renewable nature of P sources and the energy intensive production process required for the synthesis of N fertilizers. The objective of this research is to understand the relation between the municipal solid waste management (MSWM) system, both its the physical components and governance aspects, and the recovery of nutrients in Vitoria-Gasteiz (Basque Country) as a benchmark for European medium-size cities. The analysis shows that the existing physical infrastructure and facilities for bio-waste have high potential for nutrient recovery, 49% for N and 83% for P contained in bio-waste. However, governance aspects of the MSWM system such as legislation and user inclusivity play an important role and decrease the actual nutrient recovery to 3.4% and 7.4% for N and P respectively.

  11. Identification of fuel cycle simulator functionalities for analysis of transition to a new fuel cycle

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Brown, Nicholas R.; Carlsen, Brett W.; Dixon, Brent W.; Feng, Bo; Greenberg, Harris R.; Hays, Ross D.; Passerini, Stefano; Todosow, Michael; Worrall, Andrew

    2016-06-09

    Dynamic fuel cycle simulation tools are intended to model holistic transient nuclear fuel cycle scenarios. As with all simulation tools, fuel cycle simulators require verification through unit tests, benchmark cases, and integral tests. Model validation is a vital aspect as well. Although compara-tive studies have been performed, there is no comprehensive unit test and benchmark library for fuel cycle simulator tools. The objective of this paper is to identify the must test functionalities of a fuel cycle simulator tool within the context of specific problems of interest to the Fuel Cycle Options Campaign within the U.S. Department of Energy smore » Office of Nuclear Energy. The approach in this paper identifies the features needed to cover the range of promising fuel cycle options identified in the DOE-NE Fuel Cycle Evaluation and Screening (E&S) and categorizes these features to facilitate prioritization. Features were categorized as essential functions, integrating features, and exemplary capabilities. One objective of this paper is to propose a library of unit tests applicable to each of the essential functions. Another underlying motivation for this paper is to encourage an international dialog on the functionalities and standard test methods for fuel cycle simulator tools.« less

  12. High throughput reproducible cantilever functionalization

    DOE Patents [OSTI]

    Evans, Barbara R; Lee, Ida

    2014-01-21

    A method for functionalizing cantilevers is provided that includes providing a holder having a plurality of channels each having a width for accepting a cantilever probe and a plurality of probes. A plurality of cantilever probes are fastened to the plurality of channels of the holder by the spring clips. The wells of a well plate are filled with a functionalization solution, wherein adjacent wells in the well plate are separated by a dimension that is substantially equal to a dimension separating adjacent channels of the plurality of channels. Each cantilever probe that is fastened within the plurality of channels of the holder is applied to the functionalization solution that is contained in the wells of the well plate.

  13. High throughout reproducible cantilever functionalization

    DOE Patents [OSTI]

    Evans, Barbara R; Lee, Ida

    2014-11-25

    A method for functionalizing cantilevers is provided that includes providing a holder having a plurality of channels each having a width for accepting a cantilever probe and a plurality of probes. A plurality of cantilever probes are fastened to the plurality of channels of the holder by the spring clips. The wells of a well plate are filled with a functionalization solution, wherein adjacent wells in the well plate are separated by a dimension that is substantially equal to a dimension separating adjacent channels of the plurality of channels. Each cantilever probe that is fastened within the plurality of channels of the holder is applied to the functionalization solution that is contained in the wells of the well plate.

  14. Phenomenological Relativistic Energy Density Functionals

    SciTech Connect (OSTI)

    Lalazissis, G. A.; Kartzikos, S.; Niksic, T.; Paar, N.; Vretenar, D.; Ring, P.

    2009-08-26

    The framework of relativistic nuclear energy density functionals is applied to the description of a variety of nuclear structure phenomena, not only in spherical and deformed nuclei along the valley of beta-stability, but also in exotic systems with extreme isospin values and close to the particle drip-lines. Dynamical aspects of exotic nuclear structure is explored using the fully consistent quasiparticle random-phase approximation based on the relativistic Hartree-Bogoliubov model. Recent applications of energy density functionals with explicit density dependence of the meson-nucleon couplings are presented.

  15. Project X functional requirements specification

    SciTech Connect (OSTI)

    Holmes, S.D.; Henderson, S.D.; Kephart, R.; Kerby, J.; Kourbanis, I.; Lebedev, V.; Mishra, S.; Nagaitsev, S.; Solyak, N.; Tschirhart, R.; /Fermilab

    2012-05-01

    Project X is a multi-megawatt proton facility being developed to support a world-leading program in Intensity Frontier physics at Fermilab. The facility is designed to support programs in elementary particle and nuclear physics, with possible applications to nuclear energy research. A Functional Requirements Specification has been developed in order to establish performance criteria for the Project X complex in support of these multiple missions, and to assure that the facility is designed with sufficient upgrade capability to provide U.S. leadership for many decades to come. This paper will briefly review the previously described Functional Requirements, and then discuss their recent evolution.

  16. Poly(ethylene oxide) functionalization

    DOE Patents [OSTI]

    Pratt, Russell Clayton

    2014-04-08

    A simple procedure is provided by which the hydroxyl termini of poly(ethylene oxide) can be appended with functional groups to a useful extent by reaction and precipitation. The polymer is dissolved in warmed toluene, treated with an excess of organic base and somewhat less of an excess of a reactive acylating reagent, reacted for several hours, then precipitated in isopropanol so that the product can be isolated as a solid, and salt byproducts are washed away. This procedure enables functionalization of the polymer while not requiring laborious purification steps such as solvent-solvent extraction or dialysis to remove undesirable side products.

  17. Energy spectra and wave function of trigonometric Rosen-Morse potential as an effective quantum chromodynamics potential in D-dimensions

    SciTech Connect (OSTI)

    Deta, U. A.; Suparmi,; Cari,; Husein, A. S.; Yuliani, H.; Khaled, I. K. A.; Luqman, H.; Supriyanto

    2014-09-30

    The Energy Spectra and Wave Function of Schrodinger equation in D-Dimensions for trigonometric Rosen-Morse potential were investigated analytically using Nikiforov-Uvarov method. This potential captures the essential traits of the quark-gluon dynamics of Quantum Chromodynamics. The approximate energy spectra are given in the close form and the corresponding approximate wave function for arbitrary l-state (l ? 0) in D-dimensions are formulated in the form of differential polynomials. The wave function of this potential unnormalizable for general case. The wave function of this potential unnormalizable for general case. The existence of extra dimensions (centrifugal factor) and this potential increase the energy spectra of system.

  18. Physical unclonable functions: A primer

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bauer, Todd; Hamlet, Jason

    2014-11-01

    Physical unclonable functions (PUFs) make use of the measurable intrinsic randomness of physical systems to establish signatures for those systems. Thus, PUFs provide a means to generate unique keys that don't need to be stored in nonvolatile memory, and they offer exciting opportunities for new authentication and supply chain security technologies.

  19. Functional Insights from Structural Genomics

    SciTech Connect (OSTI)

    Forouhar,F.; Kuzin, A.; Seetharaman, J.; Lee, I.; Zhou, W.; Abashidze, M.; Chen, Y.; Montelione, G.; Tong, L.; et al

    2007-01-01

    Structural genomics efforts have produced structural information, either directly or by modeling, for thousands of proteins over the past few years. While many of these proteins have known functions, a large percentage of them have not been characterized at the functional level. The structural information has provided valuable functional insights on some of these proteins, through careful structural analyses, serendipity, and structure-guided functional screening. Some of the success stories based on structures solved at the Northeast Structural Genomics Consortium (NESG) are reported here. These include a novel methyl salicylate esterase with important role in plant innate immunity, a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel methyltransferase or AdoMet binding protein (A. fulgidus AF{_}0241), an ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B. melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP{_}1951), and a 12-stranded {beta}-barrel with a novel fold (V. parahaemolyticus VPA1032).

  20. The time dependent propensity function for acceleration of spatial stochastic simulation of reactiondiffusion systems

    SciTech Connect (OSTI)

    Fu, Jin; Wu, Sheng; Li, Hong; Petzold, Linda R.

    2014-10-01

    The inhomogeneous stochastic simulation algorithm (ISSA) is a fundamental method for spatial stochastic simulation. However, when diffusion events occur more frequently than reaction events, simulating the diffusion events by ISSA is quite costly. To reduce this cost, we propose to use the time dependent propensity function in each step. In this way we can avoid simulating individual diffusion events, and use the time interval between two adjacent reaction events as the simulation stepsize. We demonstrate that the new algorithm can achieve orders of magnitude efficiency gains over widely-used exact algorithms, scales well with increasing grid resolution, and maintains a high level of accuracy.

  1. Functional Stability of a Mixed Microbial Consortium Producing PHA From Waste Carbon Sources

    SciTech Connect (OSTI)

    David N. Thompson; Erik R. Coats; William A. Smith; Frank J. Loge; Michael P. Wolcott

    2006-04-01

    Polyhydroxyalkanoates (PHAs) represent an environmentally-effective alternative to synthetic thermoplastics; however, current production practices are not sustainable. In this study, PHA production was accomplished in sequencing batch bioreactors utilizing real wastewaters and mixed microbial consortia from municipal activated sludge as inoculum. Polymer production reached 85%, 53%, and 10% of the cell dry weight from methanol-enriched pulp-and-paper mill foul condensate, fermented municipal primary solids, and biodiesel wastewater, respectively. Employing denaturing gradient gel electrophoresis of 16S-rDNA from PCR-amplified DNA extracts, distinctly different communities were observed between and within wastewaters following enrichment. Most importantly, functional stability was maintained despite differing and contrasting microbial populations.

  2. Authenticating concealed private data while maintaining concealment

    DOE Patents [OSTI]

    Thomas, Edward V.; Draelos, Timothy J.

    2007-06-26

    A method of and system for authenticating concealed and statistically varying multi-dimensional data comprising: acquiring an initial measurement of an item, wherein the initial measurement is subject to measurement error; applying a transformation to the initial measurement to generate reference template data; acquiring a subsequent measurement of an item, wherein the subsequent measurement is subject to measurement error; applying the transformation to the subsequent measurement; and calculating a Euclidean distance metric between the transformed measurements; wherein the calculated Euclidean distance metric is identical to a Euclidean distance metric between the measurement prior to transformation.

  3. Maintaining System Air Quality; Industrial Technologies Program...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 * August 2004 Industrial Technologies Program Suggested Actions * Review compressed air applica- tions and determine the required level of air quality for each. * Review the ...

  4. Maintaining Your Air Conditioner | Department of Energy

    Office of Environmental Management (EM)

    filters is a critical maintenance task. | Photo courtesy of iStockphotofiremanYU. Replacing or cleaning air conditioner filters is a critical maintenance task. | Photo ...

  5. Maintaining the Stockpile | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    wave produced by the impact passes through the plutonium, and diagnostic Los Alamos Neutron Science Center LANSCE provides the scientific community with intense sources of...

  6. A tool for maintaining good combustion

    SciTech Connect (OSTI)

    Lang, B.

    1996-05-01

    There is a long list of {open_quotes}tools{close_quotes} used by waste-to-energy control room operators to keep the plant operating in accord with regulations. In many plants, the list includes a camera to view inside the furnace. And now, more plants are finding cameras can be useful in several locations within the furnace environment.

  7. Maintaining the Stockpile | National Nuclear Security Administration...

    National Nuclear Security Administration (NNSA)

    This will allow NNSA to meet today's military and national security requirements. Each ... of national policy, strategy, military, nuclear deterrence, and technology requirements. ...

  8. Maintain Pumping Systems Effectively; Industrial Technologies...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    It can also pick up system problems such as malfunctioning control valves that cause flow rate disturbances. Tracking the signature over time is more valuable than a single ...

  9. TRIDAC host computer functional specification

    SciTech Connect (OSTI)

    Hilbert, S.M.; Hunter, S.L.

    1983-08-23

    The purpose of this document is to outline the baseline functional requirements for the Triton Data Acquisition and Control (TRIDAC) Host Computer Subsystem. The requirements presented in this document are based upon systems that currently support both the SIS and the Uranium Separator Technology Groups in the AVLIS Program at the Lawrence Livermore National Laboratory and upon the specific demands associated with the extended safe operation of the SIS Triton Facility.

  10. Precision linear ramp function generator

    DOE Patents [OSTI]

    Jatko, W. Bruce (Knoxville, TN); McNeilly, David R. (Maryville, TN); Thacker, Louis H. (Knoxville, TN)

    1986-01-01

    A ramp function generator is provided which produces a precise linear ramp unction which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

  11. Semiclassical propagation of Wigner functions

    SciTech Connect (OSTI)

    Dittrich, T.; Gomez, E. A.; Pachon, L. A.

    2010-06-07

    We present a comprehensive study of semiclassical phase-space propagation in the Wigner representation, emphasizing numerical applications, in particular as an initial-value representation. Two semiclassical approximation schemes are discussed. The propagator of the Wigner function based on van Vleck's approximation replaces the Liouville propagator by a quantum spot with an oscillatory pattern reflecting the interference between pairs of classical trajectories. Employing phase-space path integration instead, caustics in the quantum spot are resolved in terms of Airy functions. We apply both to two benchmark models of nonlinear molecular potentials, the Morse oscillator and the quartic double well, to test them in standard tasks such as computing autocorrelation functions and propagating coherent states. The performance of semiclassical Wigner propagation is very good even in the presence of marked quantum effects, e.g., in coherent tunneling and in propagating Schroedinger cat states, and of classical chaos in four-dimensional phase space. We suggest options for an effective numerical implementation of our method and for integrating it in Monte-Carlo-Metropolis algorithms suitable for high-dimensional systems.

  12. Faraday dispersion functions of galaxies

    SciTech Connect (OSTI)

    Ideguchi, Shinsuke; Tashiro, Yuichi; Takahashi, Keitaro; Akahori, Takuya; Ryu, Dongsu E-mail: 136d8008@st.kumamoto-u.ac.jp E-mail: akahori@physics.usyd.edu.au

    2014-09-01

    The Faraday dispersion function (FDF), which can be derived from an observed polarization spectrum by Faraday rotation measure synthesis, is a profile of polarized emissions as a function of Faraday depth. We study intrinsic FDFs along sight lines through face-on Milky Way like galaxies by means of a sophisticated galactic model incorporating three-dimensional MHD turbulence, and investigate how much information the FDF intrinsically contains. Since the FDF reflects distributions of thermal and cosmic-ray electrons as well as magnetic fields, it has been expected that the FDF could be a new probe to examine internal structures of galaxies. We, however, find that an intrinsic FDF along a sight line through a galaxy is very complicated, depending significantly on actual configurations of turbulence. We perform 800 realizations of turbulence and find no universal shape of the FDF even if we fix the global parameters of the model. We calculate the probability distribution functions of the standard deviation, skewness, and kurtosis of FDFs and compare them for models with different global parameters. Our models predict that the presence of vertical magnetic fields and the large-scale height of cosmic-ray electrons tend to make the standard deviation relatively large. In contrast, the differences in skewness and kurtosis are relatively less significant.

  13. Window taper functions for subaperture processing. (Technical...

    Office of Scientific and Technical Information (OSTI)

    Window taper functions for subaperture processing. Citation Details In-Document Search Title: Window taper functions for subaperture processing. You are accessing a document ...

  14. Window taper functions for subaperture processing. (Technical...

    Office of Scientific and Technical Information (OSTI)

    Window taper functions for subaperture processing. Citation Details In-Document Search Title: Window taper functions for subaperture processing. It is well known that the spectrum ...

  15. Functional Design Engineering Inc | Open Energy Information

    Open Energy Info (EERE)

    Functional Design Engineering Inc Jump to: navigation, search Name: Functional Design Engineering Inc Region: United States Sector: Marine and Hydrokinetic Website:...

  16. Power Function Review (pbl/rates)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    PFR Public Comments Firstgov Power Function Review (PFR) Summary: This area of the Power Services web site provides information related to the Power Function Review (PFR). The PFR...

  17. Design Principles for Materials with Magnetic Functionality ...

    Office of Scientific and Technical Information (OSTI)

    Design Principles for Materials with Magnetic Functionality Citation Details In-Document Search Title: Design Principles for Materials with Magnetic Functionality This report ...

  18. Building a Universal Nuclear Energy Density Functional

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Building a Universal Nuclear Energy Density Functional Building a Universal Nuclear Energy Density Functional VaryMatrix.png Collaboration with mathematicians and computational...

  19. Tiny plastic lung mimics human pulmonary function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tiny plastic lung mimics human pulmonary function Tiny plastic lung mimics human pulmonary function Scientists are developing a miniature, tissue-engineered artificial lung that ...

  20. FUNCTION GENERATOR FOR ANALOGUE COMPUTERS

    DOE Patents [OSTI]

    Skramstad, H.K.; Wright, J.H.; Taback, L.

    1961-12-12

    An improved analogue computer is designed which can be used to determine the final ground position of radioactive fallout particles in an atomic cloud. The computer determines the fallout pattern on the basis of known wind velocity and direction at various altitudes, and intensity of radioactivity in the mushroom cloud as a function of particle size and initial height in the cloud. The output is then displayed on a cathode-ray tube so that the average or total luminance of the tube screen at any point represents the intensity of radioactive fallout at the geographical location represented by that point. (AEC)

  1. US Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1988-01-01

    This document provides functional organization charts for all NRC Offices and Regions, and their components.

  2. US Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1986-11-30

    Functional organization charts for the NRC Commission Offices, Divisions, and Branches are presented.

  3. Brownian dynamics without Green's functions

    SciTech Connect (OSTI)

    Delong, Steven; Donev, Aleksandar; Usabiaga, Florencio Balboa; Delgado-Buscalioni, Rafael; Griffith, Boyce E.; Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York 10016

    2014-04-07

    We develop a Fluctuating Immersed Boundary (FIB) method for performing Brownian dynamics simulations of confined particle suspensions. Unlike traditional methods which employ analytical Green's functions for Stokes flow in the confined geometry, the FIB method uses a fluctuating finite-volume Stokes solver to generate the action of the response functions on the fly. Importantly, we demonstrate that both the deterministic terms necessary to capture the hydrodynamic interactions among the suspended particles, as well as the stochastic terms necessary to generate the hydrodynamically correlated Brownian motion, can be generated by solving the steady Stokes equations numerically only once per time step. This is accomplished by including a stochastic contribution to the stress tensor in the fluid equations consistent with fluctuating hydrodynamics. We develop novel temporal integrators that account for the multiplicative nature of the noise in the equations of Brownian dynamics and the strong dependence of the mobility on the configuration for confined systems. Notably, we propose a random finite difference approach to approximating the stochastic drift proportional to the divergence of the configuration-dependent mobility matrix. Through comparisons with analytical and existing computational results, we numerically demonstrate the ability of the FIB method to accurately capture both the static (equilibrium) and dynamic properties of interacting particles in flow.

  4. Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: Essential roles of CYP2A5 and target-tissue metabolic activation

    SciTech Connect (OSTI)

    Xie Fang; Zhou Xin; Behr, Melissa; Fang Cheng; Horii, Yuichi; Gu Jun; Kannan, Kurunthachalam; Ding Xinxin

    2010-11-15

    The herbicide 2,6-dichlorobenzonitril (DCBN) is a potent and tissue-specific toxicant to the olfactory mucosa (OM). The toxicity of DCBN is mediated by cytochrome P450 (P450)-catalyzed bioactivation; however, it is not known whether target-tissue metabolic activation is essential for toxicity. CYP2A5, expressed abundantly in both liver and OM, was previously found to be one of the P450 enzymes active in DCBN bioactivation in vitro. The aims of this study were to determine the role of CYP2A5 in DCBN toxicity in vivo, by comparing the extents of DCBN toxicity between Cyp2a5-null and wild-type (WT) mice, and to determine whether hepatic microsomal P450 enzymes (including CYP2A5) are essential for the DCBN toxicity, by comparing the extents of DCBN toxicity between liver-Cpr-null (LCN) mice, which have little P450 activity in hepatocytes, and WT mice. We show that the loss of CYP2A5 expression did not alter systemic clearance of DCBN (at 25 mg/kg); but it did inhibit DCBN-induced non-protein thiol depletion and cytotoxicity in the OM. Thus, CYP2A5 plays an essential role in mediating DCBN toxicity in the OM. In contrast to the results seen in the Cyp2a5-null mice, the rates of systemic DCBN clearance were substantially reduced, while the extents of DCBN-induced nasal toxicity were increased, rather than decreased, in the LCN mice, compared to WT mice. Therefore, hepatic P450 enzymes, although essential for DCBN clearance, are not necessary for DCBN-induced OM toxicity. Our findings form the basis for a mechanism-based approach to assessing the potential risks of DCBN nasal toxicity in humans.

  5. Alkane functionalization at ([mu]-Oxo)diiron(III) centers

    SciTech Connect (OSTI)

    Leising, R.A.; Kim, J.; Perez, M.A.; Que, L. Jr. )

    1993-10-20

    The reactivity of ([mu]-oxo)diferric complexes with [sup t]BuOOH (TBHP) for the functionalization of alkanes in CH[sub 3]CN has been investigated as part of our efforts to model dinuclear sites in nonheme iron enzymes. [Fe[sub 2](TPA)[sub 2]O(OAc)](CIO[sub 4])[sub 3] (1) (TPA = tris(2-pyridylmethyl)amine, OAc = acetate) is an efficient catalyst for cyclohexane oxidation, affording cyclohexanol (A, 9 equiv), cyclohexanone (K, 11 equiv), and (tert-butylperoxy)cyclohexane (P, 16 equiv) in 0.25 h at ambient temperature and pressure under an argon atmosphere. The catalyst is remarkably robust, as indicated by the [sup 1]H NMR and UV-vis spectra of the reaction mixture during the catalytic reaction and by its ability to maintain its turnover efficiency with subsequent additions of oxidant. The catalytic mechanism for TBHP utilization was explored by observing the effects of varying the tripodal ligands on the ([mu]-oxo)([mu]-carboxylato)diferric catalysts and varying the bridge on Fe[sub 2]O(TPA)[sub 2] catalysts. The (A + K)/P ratio increased as the ligands became more electron donating. Solvent also played an important role in determining the partitioning of products between A + K and P, with benzonitrile favoring hydroxylated products at the expense of P and pyridine having the opposite effect. 49 refs., 2 figs., 3 tabs.

  6. Structures and Functions of Oligosaccharins

    SciTech Connect (OSTI)

    Albersheim, Peter

    1995-12-01

    We have made considerable progress during the 2.5 year funding period just ending in our studies of the structures and functions of oligosaccharide signal molecules (oligosaccharins). We have emphasized studies of the enzymes that solubilize, process, and degrade oligosaccharins and of the proteins that inhibit those enzymes. We have been especially interested in elucidating how oligosaccharins and their processing enzymes participate in determining the outcome of challenges to plants by pathogenic microbes. We have studied, to a lesser extent, the roles of oligosaccharins in plant growth and development. Abstracts of papers describing results acquired with support from this grant that have been published, submitted, or in preparation are presented to summarize the progress made during the last two and one half years. The report highlights the most important contributions made in our oiigosaccharin research during this time period, and the corresponding abstract is referenced. Results of work in progress are described primarily in conjunction with our application for continued support.

  7. Tn-seq of Caulobacter crescentus under uranium stress reveals genes essential for detoxification and stress tolerance

    SciTech Connect (OSTI)

    Yung, Mimi C.; Park, Dan M.; Overton, K. Wesley; Blow, Matthew J.; Hoover, Cindi A.; Smit, John R.; Murray, Sean R.; Ricci, Dante P.; Christen, Beat; Bowman, Grant R.; Jiao, Yongqin

    2015-07-20

    Ubiquitous aquatic bacterium Caulobacter crescentus is highly resistant to uranium (U) and facilitates U biomineralization and thus holds promise as an agent of U bioremediation. In order to gain an understanding of how C. crescentus tolerates U, we employed transposon (Tn) mutagenesis paired with deep sequencing (Tn-seq) in a global screen for genomic elements required for U resistance. Of the 3,879 annotated genes in the C. crescentus genome, 37 were found to be specifically associated with fitness under U stress, 15 of which were subsequently tested through mutational analysis. Systematic deletion analysis revealed that mutants lacking outer membrane transporters (rsaFa and rsaFb), a stress-responsive transcription factor (cztR), or a ppGpp synthetase/hydrolase (spoT) exhibited a significantly lower survival rate under U stress. RsaFa and RsaFb, which are homologues of TolC in Escherichia coli, have previously been shown to mediate S-layer export. Transcriptional analysis revealed upregulation of rsaFa and rsaFb by 4- and 10-fold, respectively, in the presence of U. We additionally show that rsaFa mutants accumulated higher levels of U than the wild type, with no significant increase in oxidative stress levels. These results suggest a function for RsaFa and RsaFb in U efflux and/or maintenance of membrane integrity during U stress. In addition, we present data implicating CztR and SpoT in resistance to U stress. Together, our findings reveal novel gene targets that are key to understanding the molecular mechanisms of U resistance in C. crescentus.

  8. Tn-seq of Caulobacter crescentus under uranium stress reveals genes essential for detoxification and stress tolerance

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yung, Mimi C.; Park, Dan M.; Overton, K. Wesley; Blow, Matthew J.; Hoover, Cindi A.; Smit, John R.; Murray, Sean R.; Ricci, Dante P.; Christen, Beat; Bowman, Grant R.; et al

    2015-07-20

    Ubiquitous aquatic bacterium Caulobacter crescentus is highly resistant to uranium (U) and facilitates U biomineralization and thus holds promise as an agent of U bioremediation. In order to gain an understanding of how C. crescentus tolerates U, we employed transposon (Tn) mutagenesis paired with deep sequencing (Tn-seq) in a global screen for genomic elements required for U resistance. Of the 3,879 annotated genes in the C. crescentus genome, 37 were found to be specifically associated with fitness under U stress, 15 of which were subsequently tested through mutational analysis. Systematic deletion analysis revealed that mutants lacking outer membrane transporters (rsaFamore » and rsaFb), a stress-responsive transcription factor (cztR), or a ppGpp synthetase/hydrolase (spoT) exhibited a significantly lower survival rate under U stress. RsaFa and RsaFb, which are homologues of TolC in Escherichia coli, have previously been shown to mediate S-layer export. Transcriptional analysis revealed upregulation of rsaFa and rsaFb by 4- and 10-fold, respectively, in the presence of U. We additionally show that rsaFa mutants accumulated higher levels of U than the wild type, with no significant increase in oxidative stress levels. These results suggest a function for RsaFa and RsaFb in U efflux and/or maintenance of membrane integrity during U stress. In addition, we present data implicating CztR and SpoT in resistance to U stress. Together, our findings reveal novel gene targets that are key to understanding the molecular mechanisms of U resistance in C. crescentus.« less

  9. Hsp100/ClpB Chaperone Function and Mechanism

    SciTech Connect (OSTI)

    Vierling, Elizabeth

    2015-01-27

    The supported research investigated the mechanism of action of a unique class of molecular chaperones in higher plants, the Hsp100/ClpB proteins, with the ultimate goal of defining how these chaperones influence plant growth, development, stress tolerance and productivity. Molecular chaperones are essential effectors of cellular “protein quality control”, which comprises processes that ensure the proper folding, localization, activation and turnover of proteins. Hsp100/ClpB proteins are required for temperature acclimation in plants, optimal seed yield, and proper chloroplast development. The model plant Arabidopsis thaliana and genetic and molecular approaches were used to investigate two of the three members of the Hsp100/ClpB proteins in plants, cytosolic AtHsp101 and chloroplast-localized AtClpB-p. Investigating the chaperone activity of the Hsp100/ClpB proteins addresses DOE goals in that this activity impacts how “plants generate and assemble components” as well as “allowing for their self repair”. Additionally, Hsp100/ClpB protein function in plants is directly required for optimal “utilization of biological energy” and is involved in “mechanisms that control the architecture of energy transduction systems”.

  10. Predicting Stability Constants for Uranyl Complexes Using Density Functional Theory

    SciTech Connect (OSTI)

    Vukovic, Sinisa; Hay, Benjamin P.; Bryantsev, Vyacheslav S.

    2015-04-02

    The ability to predict the equilibrium constants for the formation of 1:1 uranyl:ligand complexes (log K1 values) provides the essential foundation for the rational design of ligands with enhanced uranyl affinity and selectivity. We also use density functional theory (B3LYP) and the IEFPCM continuum solvation model to compute aqueous stability constants for UO22+ complexes with 18 donor ligands. Theoretical calculations permit reasonably good estimates of relative binding strengths, while the absolute log K1 values are significantly overestimated. Accurate predictions of the absolute log K1 values (root mean square deviation from experiment < 1.0 for log K1 values ranging from 0 to 16.8) can be obtained by fitting the experimental data for two groups of mono and divalent negative oxygen donor ligands. The utility of correlations is demonstrated for amidoxime and imide dioxime ligands, providing a useful means of screening for new ligands with strong chelate capability to uranyl.

  11. Predicting Stability Constants for Uranyl Complexes Using Density Functional Theory

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Vukovic, Sinisa; Hay, Benjamin P.; Bryantsev, Vyacheslav S.

    2015-04-02

    The ability to predict the equilibrium constants for the formation of 1:1 uranyl:ligand complexes (log K1 values) provides the essential foundation for the rational design of ligands with enhanced uranyl affinity and selectivity. We also use density functional theory (B3LYP) and the IEFPCM continuum solvation model to compute aqueous stability constants for UO22+ complexes with 18 donor ligands. Theoretical calculations permit reasonably good estimates of relative binding strengths, while the absolute log K1 values are significantly overestimated. Accurate predictions of the absolute log K1 values (root mean square deviation from experiment < 1.0 for log K1 values ranging from 0more » to 16.8) can be obtained by fitting the experimental data for two groups of mono and divalent negative oxygen donor ligands. The utility of correlations is demonstrated for amidoxime and imide dioxime ligands, providing a useful means of screening for new ligands with strong chelate capability to uranyl.« less

  12. Ecological function and resilience: Neglected criteria for environmental impact assessment and ecological risk analysis

    SciTech Connect (OSTI)

    Cairns, J. Jr.; Niederlehner, B.R. . Univ. Center for Environmental and Hazardous Materials Studies)

    1993-01-01

    The importance of establishing methods for determining ecological function and resilience transcends scientific interest; these methods are important to sustained societal use of ecosystems and long-term productivity. Essential services that ecosystems provide to human society include water purification, oxygen production, carbon storage, climate regulation, and production of food, wood, and medicinal drugs. Although man is dependent upon these services, human understanding of the dynamics of ecosystem function is limited. Man can detect gross impairment of ecosystem function or resilience after the fact. However, protecting ecosystem health necessitates detecting adverse trends in ecological function, rather than reacting when the system collapses. The information to date is inadequate for predicting subtle changes or incremental trends. Once ecosystems are damaged and therefore providing diminished services, it is important to determine when they will be restored to an approximation of their predisturbance condition. For those ecosystems unlikely to recover on their own, management techniques may enhance recovery processes. Information about response of ecosystem function to human actions and relative resilience of alternative ecosystems can facilitate decision-making under the National Environmental Policy Act (NEPA).

  13. Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

    SciTech Connect (OSTI)

    Premkumar, Lakshmanane, E-mail: p.lakshmanane@imb.uq.edu.au; Heras, Begoa; Duprez, Wilko; Walden, Patricia; Halili, Maria; Kurth, Fabian; Fairlie, David P.; Martin, Jennifer L., E-mail: p.lakshmanane@imb.uq.edu.au [University of Queensland, St Lucia, QLD 4067 (Australia)

    2013-10-01

    The gene product of M. tuberculosis Rv2969c is shown to be a disulfide oxidase enzyme that has a canonical DsbA-like fold with novel structural and functional characteristics. The bacterial disulfide machinery is an attractive molecular target for developing new antibacterials because it is required for the production of multiple virulence factors. The archetypal disulfide oxidase proteins in Escherichia coli (Ec) are DsbA and DsbB, which together form a functional unit: DsbA introduces disulfides into folding proteins and DsbB reoxidizes DsbA to maintain it in the active form. In Mycobacterium tuberculosis (Mtb), no DsbB homologue is encoded but a functionally similar but structurally divergent protein, MtbVKOR, has been identified. Here, the Mtb protein Rv2969c is investigated and it is shown that it is the DsbA-like partner protein of MtbVKOR. It is found that it has the characteristic redox features of a DsbA-like protein: a highly acidic catalytic cysteine, a highly oxidizing potential and a destabilizing active-site disulfide bond. Rv2969c also has peptide-oxidizing activity and recognizes peptide segments derived from the periplasmic loops of MtbVKOR. Unlike the archetypal EcDsbA enzyme, Rv2969c has little or no activity in disulfide-reducing and disulfide-isomerase assays. The crystal structure of Rv2969c reveals a canonical DsbA fold comprising a thioredoxin domain with an embedded helical domain. However, Rv2969c diverges considerably from other DsbAs, including having an additional C-terminal helix (H8) that may restrain the mobility of the catalytic helix H1. The enzyme is also characterized by a very shallow hydrophobic binding surface and a negative electrostatic surface potential surrounding the catalytic cysteine. The structure of Rv2969c was also used to model the structure of a paralogous DsbA-like domain of the Ser/Thr protein kinase PknE. Together, these results show that Rv2969c is a DsbA-like protein with unique properties and a limited

  14. US Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1990-08-15

    Functional organization charts for the US Nuclear Regulatory Commission offices, divisions, and branches are presented in this document.

  15. US Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1990-04-01

    Functional organization charts for the US Nuclear Regulatory Commission offices, divisions, and branches are presented in this document.

  16. Functional Area Qualification Standard Reference Guides

    Broader source: Energy.gov [DOE]

    The reference guides have been developed to address the competency statements in DOE Functional Area Qualification Standard.

  17. Fire Protection Engineering Functional Area Qualification Standard

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    FIRE PROTECTION ENGINEERING FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical ... by applied engineering fundamentals, research, fire hazard ...

  18. Property:Distributed Generation Function | Open Energy Information

    Open Energy Info (EERE)

    Function Jump to: navigation, search Property Name Distributed Generation Function Property Type Page Description A description of the function(s) for which the Distributed...

  19. Polarized structure functions in nuclear matter

    SciTech Connect (OSTI)

    Tehrani, S. Atashbar; Khorramian, A. N.; Monfared, S. Taheri; Arbabifar, F.

    2011-10-24

    We present a comprehensive analysis of the structure functions for the polarized nuclei {sup 3}He, and focus on the polarized distribution functions and light-cone momentum distributions of protons and neutrons. We demonstrate that the first moment of the {sup 3}He structure function can provide an incisive test of the Bjorken sum rule.

  20. A description of the location and structure of the essential spectrum of a model operator in a subspace of a Fock space

    SciTech Connect (OSTI)

    Yodgorov, G R; Ismail, F; Muminov, Z I

    2014-12-31

    We consider a certain model operator acting in a subspace of a fermionic Fock space. We obtain an analogue of Faddeev's equation. We describe the location of the essential spectrum of the operator under consideration and show that the essential spectrum consists of the union of at most four segments. Bibliography: 19 titles.

  1. Characterizing quasiconvex functions in terms of the Kronrod's tree of a function

    SciTech Connect (OSTI)

    Vorob'ev, A. I.

    2014-06-01

    As an application of Kronrod's construction of the tree of a function to convex analysis, a characterization of quasiconvex functions is obtained. Namely, a function is quasiconvex if and only if the associated function defined on the tree of the original function is quasiconvex. A new proof of one of the existence lemmas in Kronrod's construction of the tree of a function (the original proof of which turned out to be incorrect) is given. Bibliography: 4 titles. (paper)

  2. Holography of gravitational action functionals

    SciTech Connect (OSTI)

    Mukhopadhyay, Ayan; Padmanabhan, T.

    2006-12-15

    Einstein-Hilbert (EH) action can be separated into a bulk and a surface term, with a specific ('holographic') relationship between the two, so that either can be used to extract information about the other. The surface term can also be interpreted as the entropy of the horizon in a wide class of spacetimes. Since EH action is likely to just the first term in the derivative expansion of an effective theory, it is interesting to ask whether these features continue to hold for more general gravitational actions. We provide a comprehensive analysis of Lagrangians of the form {radical}(-g)L={radical}(-g)Q{sub a}{sup bcd}R{sup a}{sub bcd}, in which Q{sub a}{sup bcd} is a tensor with the symmetries of the curvature tensor, made from metric and curvature tensor and satisfies the condition {nabla}{sub c}Q{sub a}{sup bcd}=0, and show that they share these features. The Lanczos-Lovelock Lagrangians are a subset of these in which Q{sub a}{sup bcd} is a homogeneous function of the curvature tensor. They are all holographic, in a specific sense of the term, and--in all these cases--the surface term can be interpreted as the horizon entropy. The thermodynamics route to gravity, in which the field equations are interpreted as TdS=dE+pdV, seems to have a greater degree of validity than the field equations of Einstein gravity itself. The results suggest that the holographic feature of EH action could also serve as a new symmetry principle in constraining the semiclassical corrections to Einstein gravity. The implications are discussed.

  3. Functionalized lignin, rubber containing functionalized lignin and products containing such rubber composition

    DOE Patents [OSTI]

    Benko, David Andrew; Hahn, Bruce Raymond; Cohen, Martin Paul; Dirk, Shawn Matthew; Cicotte, Kirsten Nicole

    2014-03-04

    The invention relates to functionalized lignin, rubber compositions which contain functionalized lignin and to products which have at least one component comprised of such rubber composition.

  4. Function point count adjustment by means of scaling touched function points

    SciTech Connect (OSTI)

    Bell, M.

    1997-11-01

    This report contains viewgraphs on the use of scaling touched function points to adjust function point analysis in determine the usefullness, productivity, and quality of software.

  5. Osteocalcin protects pancreatic beta cell function and survival under high glucose conditions

    SciTech Connect (OSTI)

    Kover, Karen; Yan, Yun; Tong, Pei Ying; Watkins, Dara; Li, Xiaoyu; Tasch, James; Hager, Melissa; Clements, Mark; Moore, Wayne V.

    2015-06-19

    Diabetes is characterized by progressive beta cell dysfunction and loss due in part to oxidative stress that occurs from gluco/lipotoxicity. Treatments that directly protect beta cell function and survival in the diabetic milieu are of particular interest. A growing body of evidence suggests that osteocalcin, an abundant non-collagenous protein of bone, supports beta cell function and proliferation. Based on previous gene expression data by microarray, we hypothesized that osteocalcin protects beta cells from glucose-induced oxidative stress. To test our hypothesis we cultured isolated rat islets and INS-1E cells in the presence of normal, high, or high glucose ± osteocalcin for up to 72 h. Oxidative stress and viability/mitochondrial function were measured by H{sub 2}O{sub 2} assay and Alamar Blue assay, respectively. Caspase 3/7 activity was also measured as a marker of apoptosis. A functional test, glucose stimulated insulin release, was conducted and expression of genes/protein was measured by qRT-PCR/western blot/ELISA. Osteocalcin treatment significantly reduced high glucose-induced H{sub 2}O{sub 2} levels while maintaining viability/mitochondrial function. Osteocalcin also significantly improved glucose stimulated insulin secretion and insulin content in rat islets after 48 h of high glucose exposure compared to untreated islets. As expected sustained high glucose down-regulated gene/protein expression of INS1 and BCL2 while increasing TXNIP expression. Interestingly, osteocalcin treatment reversed the effects of high glucose on gene/protein expression. We conclude that osteocalcin can protect beta cells from the negative effects of glucose-induced oxidative stress, in part, by reducing TXNIP expression, thereby preserving beta cell function and survival. - Highlights: • Osteocalcin reduces glucose-induced oxidative stress in beta cells. • Osteocalcin preserves beta cell function and survival under stress conditions. • Osteocalcin reduces glucose

  6. Functional Encyclopedia of Bacteria and Archaea

    SciTech Connect (OSTI)

    Blow, M. J.; Deutschbauer, A. M.; Hoover, C. A.; Lamson, J.; Lamson, J.; Price, M. N.; Waters, J.; Wetmore, K. M.; Bristow, J.; Arkin, A. P.

    2013-03-20

    Bacteria and Archaea exhibit a huge diversity of metabolic capabilities with fundamental importance in the environment, and potential applications in biotechnology. However, the genetic bases of these capabilities remain unclear due largely to an absence of technologies that link DNA sequence to molecular function. To address this challenge, we are developing a pipeline for high throughput annotation of gene function using mutagenesis, growth assays and DNA sequencing. By applying this pipeline to annotate gene function in 50 diverse microbes we hope to discover thousands of new gene functions and produce a proof of principle `Functional Encyclopedia of Bacteria and Archaea?.

  7. Functionalized active-nucleus complex sensor

    DOE Patents [OSTI]

    Pines, Alexander; Wemmer, David E.; Spence, Megan; Rubin, Seth

    2003-11-25

    A functionalized active-nucleus complex sensor that selectively associates with one or more target species, and a method for assaying and screening for one or a plurality of target species utilizing one or a plurality of functionalized active-nucleus complexes with at least two of the functionalized active-nucleus complexes having an attraction affinity to different corresponding target species. The functionalized active-nucleus complex has an active-nucleus and a targeting carrier. The method involves functionalizing an active-nucleus, for each functionalized active-nucleus complex, by incorporating the active-nucleus into a macromolucular or molecular complex that is capable of binding one of the target species and then bringing the macromolecular or molecular complexes into contact with the target species and detecting the occurrence of or change in a nuclear magnetic resonance signal from each of the active-nuclei in each of the functionalized active-nucleus complexes.

  8. Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis

    SciTech Connect (OSTI)

    Harrison, Anthony J.; Ramsay, Rochelle J.; Baker, Edward N.; Lott, J. Shaun

    2005-01-01

    MbtI, the putative isochorismate synthase essential for siderophore biosynthesis in M. tuberculosis, has been crystallized. Diffraction data have been collected to 1.8 resolution. Mycobacterium tuberculosis, the causative agent of tuberculosis, depends on the secretion of salicylate-based siderophores called mycobactins for the acquisition of extracellular iron, which is essential for the growth and virulence of the bacterium. The protein MbtI is thought to be the isochorismate synthase enzyme responsible for the conversion of chorismate to isochorismate, the first step in the salicylate production required for mycobactin biosynthesis. MbtI has been overexpressed in Escherichia coli, purified and crystallized. The crystals diffract to a maximum resolution of 1.8 . They belong to space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 51.8, b = 163.4, c = 194.9 , consistent with the presence of either two, three or four molecules in the asymmetric unit.

  9. The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt

    SciTech Connect (OSTI)

    Clements, Craig S.; Kjer-Nielsen, Lars; Kostenko, Lyudmila; McCluskey, James; Rossjohn, Jamie

    2006-01-01

    X-ray diffraction data were collected to 1.9 from crystals of HLA-G. Cobalt ions were found to be essential for the production of diffracting crystals. HLA-G is a nonclassical class I major histocompatibility complex (MHC) molecule that is primarily expressed at the foetalmaternal interface. Although the role of HLA-G has not been fully elucidated, current evidence suggests it protects the foetus from the maternal immune response. In this report, HLA-G (44 kDa) is characterized by expression in Escherichia coli. The inclusion bodies were refolded in complex with a peptide derived from histone H2A (RIIPRHLQL), purified and subsequently crystallized. Correct refolding was determined using two conformation-dependent antibodies. Cobalt ions were shown to be an essential ingredient for obtaining diffraction-quality crystals. The crystals, which diffracted to 1.9 resolution, belonged to space group P3{sub 2}2{sub 1}, with unit-cell parameters a = b = 77.15, c = 151.72 .

  10. CTA/CNS Functions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    CTA/CNS Functions CTA/CNS Functions CTA/CNS Functions The Secretary established the mission of the Chief Technical Authority (CTA) and supporting Chief of Nuclear Safety (CNS) in 2005 to provide independent analysis, advice, and recommendations to DOE senior management, program offices, field offices, and contractors on the health of the oversight and practices associated with the nuclear facility safety. Beginning in 2011, the Deputy Secretary also delegated EM CTA responsibilities to the CNS.

  11. Accurate evaluation of pionium wave functions

    SciTech Connect (OSTI)

    Suebka, P.; Yan, Y.

    2004-09-01

    A suitable numerical approach based on Sturmian functions is employed to solve the pionium problem for both local and nonlocal potentials. The approach accounts for both the short-ranged strong interaction and the long-ranged Coulomb force and provides accurately the wave function and binding energy of pionium. It is found that the ground-state pionium wave function in realistic pion-pion strong interactions might be considerably different from the hydrogen-like one at a small distance.

  12. The integrated Earth System Model Version 1: formulation and functionality

    SciTech Connect (OSTI)

    Collins, William D.; Craig, Anthony P.; Truesdale, John E.; Di Vittorio, Alan; Jones, Andrew D.; Bond-Lamberty, Benjamin; Calvin, Katherine V.; Edmonds, James A.; Kim, Son H.; Thomson, Allison M.; Patel, Pralit L.; Zhou, Yuyu; Mao, Jiafu; Shi, Xiaoying; Thornton, Peter E.; Chini, Louise M.; Hurtt, George C.

    2015-07-23

    The integrated Earth System Model (iESM) has been developed as a new tool for pro- jecting the joint human/climate system. The iESM is based upon coupling an Integrated Assessment Model (IAM) and an Earth System Model (ESM) into a common modeling in- frastructure. IAMs are the primary tool for describing the human–Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species, land use and land cover change, and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. The iESM project integrates the economic and human dimension modeling of an IAM and a fully coupled ESM within a sin- gle simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore- omitted feedbacks between natural and societal drivers, we can improve scientific under- standing of the human–Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper de- scribes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.

  13. The integrated Earth system model version 1: formulation and functionality

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Collins, W. D.; Craig, A. P.; Truesdale, J. E.; Di Vittorio, A. V.; Jones, A. D.; Bond-Lamberty, B.; Calvin, K. V.; Edmonds, J. A.; Kim, S. H.; Thomson, A. M.; et al

    2015-07-23

    The integrated Earth system model (iESM) has been developed as a new tool for projecting the joint human/climate system. The iESM is based upon coupling an integrated assessment model (IAM) and an Earth system model (ESM) into a common modeling infrastructure. IAMs are the primary tool for describing the human–Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species (SLS), land use and land cover change (LULCC), and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. Themore » iESM project integrates the economic and human-dimension modeling of an IAM and a fully coupled ESM within a single simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore-omitted feedbacks between natural and societal drivers, we can improve scientific understanding of the human–Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper describes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.« less

  14. Crystal Structure and Functional Analysis Identify Evolutionary...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    domains are considered to be markers for tRNA synthetase-associated functions beyond translation (1). Although their appearance correlates with the increase of biological...

  15. Building a Universal Nuclear Energy Density Functional

    SciTech Connect (OSTI)

    Bertulani, Carlos A.

    2014-09-10

    This grant had two components: Density functional theory and pairing and Nuclear reactions. This final report summarizes the activities for this SciDAC-2 project.

  16. Functionalized mesoporous materials for adsorption and release...

    Office of Scientific and Technical Information (OSTI)

    Citation Details In-Document Search Title: Functionalized ... This work reports comparative studies of the adsorption and ... OSTI Identifier: 21370463 Resource Type: Journal Article ...

  17. Poly(ethyleneoxide) functionalization through alkylation (Patent...

    Office of Scientific and Technical Information (OSTI)

    A new and efficient method of functionalizing high molecular weight polymers through alkylation using a metal amide base is described. This novel procedure can also be used to ...

  18. Functionalized High Performance Polymer Membranes for Separation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Functionalized High Performance Polymer Membranes for Separation of Carbon Dioxide and Methane Previous Next List Natalia Blinova and Frantisek Svec, J. Mater. Chem. A, 2, 600-604...

  19. Functionalized Polyacrylamide Monolith for Rapid Bacteria Pathogen...

    Office of Scientific and Technical Information (OSTI)

    for Rapid Bacteria Pathogen Detection in Human Blood. Citation Details In-Document Search Title: Functionalized Polyacrylamide Monolith for Rapid Bacteria Pathogen ...

  20. Dual Functional Cathode Additives for Battery Technologies -...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Return to Search Dual Functional Cathode Additives for Battery Technologies Brookhaven ... activation of the cell of a lithium battery having a primary metal sulfide additive ...

  1. Contrasting soil microbial community functional structures in...

    Office of Scientific and Technical Information (OSTI)

    Contrasting soil microbial community functional structures in two major landscapes of the Tibetan alpine meadow Prev Next Title: Contrasting soil microbial community...

  2. Design Principles for Materials with Magnetic Functionality

    SciTech Connect (OSTI)

    Thompson, Joe David

    2015-11-05

    This report describes the processes involved with refining and testing design principles of high density, magnetic materials and while observing their magnetic functionality.

  3. Universal Nuclear Energy Density Functional (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Country of Publication: United States Language: English Subject: 73 NUCLEAR PHYSICS AND RADIATION PHYSICS Nuclear structure; nuclear energy density functional Word Cloud ...

  4. Emergency Support Function #12; Energy Annex

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Consequently, energy supply and transportation problems can ... Emergency Support Function 12 - Energy Annex ESF 12-2 ESF ... into ESF 12 planning and decisionmaking processes. ...

  5. Methods of electrophoretic deposition for functionally graded...

    Office of Scientific and Technical Information (OSTI)

    Methods of electrophoretic deposition for functionally graded porous nanostructures and ... and depositing the material onto surfaces of the particles of the impurity to form ...

  6. Quality Assurance Functional Area Qualification Standard - DOE...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    establishes common functional area competency requirements for DOE personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical QA...

  7. Quality Assurance Functional Area Qualification Standard - DOE...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    common functional area competency requirements for all DOE QA personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical...

  8. Guidance on Inherently Governmental Functions | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    Federal law prohibits contractors from performing "inherently governmental functions." This guidance is designed to provide the basic rules applicable to the Department....

  9. Perturbation kernels for generalized seismological data functionals...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Authors: Chen, Po., Jordan, T.H., Lee, E. In seismic waveform analysis and inversion, data ... The generalized seismological data functionals (GSDF) of Gee & Jordan quantify waveform ...

  10. Contrasting soil microbial community functional structures in...

    Office of Scientific and Technical Information (OSTI)

    two major landscapes of the Tibetan alpine meadow Prev Next Title: Contrasting soil microbial community functional structures in two major landscapes of the Tibetan alpine...

  11. Safety Software Quality Assurance Functional Area Qualification...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    72-2011, Safety Software Quality Assurance Functional Area Qualification Standard by Diane Johnson This SSQA FAQS identifies the minimum technical competency requirements for DOE...

  12. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    nanosheets for novel functions. The substitution of oil in place of air creates a raft of new opportunities for the engineering and production of peptoid nanosheets. For...

  13. Uncertainty Quantification for Nuclear Density Functional Theory...

    Office of Scientific and Technical Information (OSTI)

    Uncertainty Quantification for Nuclear Density Functional Theory and Information Content of New Measurements Citation Details In-Document Search This content will become publicly...

  14. Beyond simple exponential correlation functions and equilibrium...

    Office of Scientific and Technical Information (OSTI)

    and equilibrium dynamics in x-ray photon correlation spectroscopy Citation Details In-Document Search Title: Beyond simple exponential correlation functions and equilibrium ...

  15. Critical function and success path summary display

    DOE Patents [OSTI]

    Scarola, Kenneth; Jamison, David S.; Manazir, Richard M.; Rescorl, Robert L.; Harmon, Daryl L.

    1995-01-01

    The content of and hierarchical access to three levels of display pages containing information on critical function monitoring and success path monitoring.

  16. POLICY GUIDANCE MEMORANDUM #25 Functional Accountability | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Policy Statement reiterating that the Human Resources Directors (HRDs) are accountable to the Chief Human Capital Officer (CHCO) on matters pertaining to Functional Accountability. ...

  17. Cross-Linked Conjugated Polymer Fibrils: Robust Nanowires from Functional Polythiophene Diblock Copolymers

    SciTech Connect (OSTI)

    Hammer, Brenton A. G.; Bokel, Felicia A.; Hayward, Ryan C.; Emrick, Todd

    2011-09-27

    A series of poly(3-hexyl thiophene) (P3HT)-based diblock copolymers were prepared and examined in solution for their assembly into fibrils, and post-assembly cross-linking into robust nanowire structures. P3HT-b-poly(3-methanol thiophene) (P3MT), and P3HT-b-poly(3-aminopropyloxymethyl thiophene) (P3AmT) diblock copolymers were synthesized using Grignard metathesis (GRIM) polymerization. Fibrils formed from solution assembly of these copolymers are thus decorated with hydroxyl and amine functionality, and cross-linking is achieved by reaction of diisocyanates with the hydroxyl and amine groups. A variety of cross-linked structures, characterized by transmission electron microscopy (TEM), were produced by this method, including dense fibrillar sheets, fibril bundles, or predominately individual fibrils, depending on the chosen reaction conditions. In solution, the cross-linked fibrils maintained their characteristic vibronic structure in solvents that would normally disrupt (dissolve) the structures.

  18. Computational design of intrinsic molecular rectifiers based on asymmetric functionalization of N-phenylbenzamide

    SciTech Connect (OSTI)

    Ding, Wendu; Koepf, Matthieu; Koenigsmann, Christopher; Batra, Arunabh; Venkataraman, Latha; Negre, Christian F. A.; Brudvig, Gary W.; Crabtree, Robert H.; Schmuttenmaer, Charles A.; Batista, Victor S.

    2015-11-03

    Here, we report a systematic computational search of molecular frameworks for intrinsic rectification of electron transport. The screening of molecular rectifiers includes 52 molecules and conformers spanning over 9 series of structural motifs. N-Phenylbenzamide is found to be a promising framework with both suitable conductance and rectification properties. A targeted screening performed on 30 additional derivatives and conformers of N-phenylbenzamide yielded enhanced rectification based on asymmetric functionalization. We demonstrate that electron-donating substituent groups that maintain an asymmetric distribution of charge in the dominant transport channel (e.g., HOMO) enhance rectification by raising the channel closer to the Fermi level. These findings are particularly valuable for the design of molecular assemblies that could ensure directionality of electron transport in a wide range of applications, from molecular electronics to catalytic reactions.

  19. Computational design of intrinsic molecular rectifiers based on asymmetric functionalization of N-phenylbenzamide

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ding, Wendu; Koepf, Matthieu; Koenigsmann, Christopher; Batra, Arunabh; Venkataraman, Latha; Negre, Christian F. A.; Brudvig, Gary W.; Crabtree, Robert H.; Schmuttenmaer, Charles A.; Batista, Victor S.

    2015-11-03

    Here, we report a systematic computational search of molecular frameworks for intrinsic rectification of electron transport. The screening of molecular rectifiers includes 52 molecules and conformers spanning over 9 series of structural motifs. N-Phenylbenzamide is found to be a promising framework with both suitable conductance and rectification properties. A targeted screening performed on 30 additional derivatives and conformers of N-phenylbenzamide yielded enhanced rectification based on asymmetric functionalization. We demonstrate that electron-donating substituent groups that maintain an asymmetric distribution of charge in the dominant transport channel (e.g., HOMO) enhance rectification by raising the channel closer to the Fermi level. These findingsmore » are particularly valuable for the design of molecular assemblies that could ensure directionality of electron transport in a wide range of applications, from molecular electronics to catalytic reactions.« less

  20. Rendering graphene supports hydrophilic with non-covalent aromatic functionalization for transmission electron microscopy

    SciTech Connect (OSTI)

    Pantelic, Radosav S., E-mail: pantelic@imbb.forth.gr [National Cancer Institute, 50 South Drive, Building 50, Room 4306, Bethesda, Maryland 20892 (United States); Fu, Wangyang; Schoenenberger, Christian [Department of Physics, University of Basel, Klingelbergstrasse 82, Basel CH-4056 (Switzerland); Stahlberg, Henning [Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, Mattenstrasse 26, WRO-1058, Basel CH-4058 (Switzerland)

    2014-03-31

    Amorphous carbon films have been routinely used to enhance the preparation of frozen-hydrated samples for transmission electron microscopy (TEM), either in retaining protein concentration, providing mechanical stability or dissipating sample charge. However, strong background signal from the amorphous carbon support obstructs that of the sample, and the insulating properties of thin amorphous carbon films preclude any efficiency in dispersing charge. Graphene addresses the limitations of amorphous carbon. Graphene is a crystalline material with virtually no phase or amplitude contrast and unparalleled, high electrical carrier mobility. However, the hydrophobic properties of graphene have prevented its routine application in Cryo-TEM. This Letter reports a method for rendering graphene TEM supports hydrophilica convenient approach maintaining graphene's structural and electrical properties based on non-covalent, aromatic functionalization.

  1. Design review plan for Multi-Function Waste Tank Facility (Project W-236A)

    SciTech Connect (OSTI)

    Renfro, G.G.

    1994-12-20

    This plan describes how the Multi-Function Waste Tank Facility (MWTF) Project conducts reviews of design media; describes actions required by Project participants; and provides the methodology to ensure that the design is complete, meets the technical baseline of the Project, is operable and maintainable, and is constructable. Project W-236A is an integrated project wherein the relationship between the operating contractor and architect-engineer is somewhat different than that of a conventional project. Working together, Westinghouse Hanford Company (WHC) and ICF Karser Hanford (ICF KH) have developed a relationship whereby ICF KH performs extensive design reviews and design verification. WHC actively participates in over-the-shoulder reviews during design development, performs a final review of the completed design, and conducts a formal design review of the Safety Class I, ASME boiler and Pressure Vessel Code items in accordance with WHC-CM-6-1, Standard Engineering Practices.

  2. Functional design criteria for FY 1993-2000 groundwater monitoring wells

    SciTech Connect (OSTI)

    Williams, B.A.

    1996-01-01

    The purpose of this revision is to update the Line Item Project, 93-L-GFW-152 Functional Design Criteria (FDC) to reflect changes approved in change control M-24-91-6, Engineering Change Notices (ECNs), and expand the scope to include subsurface investigations along with the borehole drilling. This revision improves the ability and effectiveness of maintaining RCRA and Operational groundwater compliance by combining borehole and well drilling with subsurface data gathering objectives. The total projected number of wells to be installed under this project has decreased from 200 and the scope has been broadened to include additional subsurface investigation activities that usually occur simultaneously with most traditional borehole drilling and monitoring well installations. This includes borehole hydrogeologic characterization activities, and vadose monitoring. These activities are required under RCRA 40 CFR 264 and 265 and WAC 173-303 for site characterization, groundwater and vadose assessment and well placement.

  3. Eta Structure Function via Photo-production

    SciTech Connect (OSTI)

    Ghahramany, N.; Ghanaatian, M.; Bazrafshan, A.

    2008-04-21

    By using isobar model and the latest data, the structure function of Eta particle is calculated in the process of photo-production. This calculation is carried out for photon energy range of 0.750-3 GeV. The variations of the structure function are given in terms of scattering angle for different incoming photon energy.

  4. Network architecture functional description and design

    SciTech Connect (OSTI)

    Stans, L.; Bencoe, M.; Brown, D.; Kelly, S.; Pierson, L.; Schaldach, C.

    1989-05-25

    This report provides a top level functional description and design for the development and implementation of the central network to support the next generation of SNL, Albuquerque supercomputer in a UNIX{reg sign} environment. It describes the network functions and provides an architecture and topology.

  5. Quality Assurance Functional Area Qualification Standard

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2013-12-02

    The Quality Assurance (QA) Functional Area Qualification Standard (FAQS) establishes common functional area competency requirements for all DOE QA personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical activities that could impact the safe operation of DOE’s defense nuclear facilities.

  6. Quality Assurance Functional Area Qualification Standard

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2002-04-22

    Replaced by DOE-1150-2013 This QA Functional Area Qualification Standard establishes common functional area competency requirements for DOE personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical QA activities impacting the safe operation of defense nuclear facilities.

  7. Oligomer functionalized nanotubes and composites formed therewith

    DOE Patents [OSTI]

    Zettl, Alexander K; Sainsbury, Toby; Frechet, Jean M.J.

    2014-03-18

    Disclosed herein is a sequential functionalization methodology for the covalent modification of nanotubes with between one and four repeat units of a polymer. Covalent attachment of oligomer units to the surface of nanotubes results in oligomer units forming an organic sheath around the nanotubes, polymer-functionalized-nanotubes (P-NTs). P-NTs possess chemical functionality identical to that of the functionalizing polymer, and thus provide nanoscale scaffolds which may be readily dispersed within a monomer solution and participate in the polymerization reaction to form a polymer-nanotube/polymer composite. Formation of polymer in the presence of P-NTs leads to a uniform dispersion of nanotubes within the polymer matrix, in contrast to aggregated masses of nanotubes in the case of pristine-NTs. The covalent attachment of oligomeric units to the surface of nanotubes represents the formation of a functional nanoscale building block which can be readily dispersed and integrated within the polymer to form a novel composite material.

  8. Low work function, stable thin films

    DOE Patents [OSTI]

    Dinh, Long N.; McLean, II, William; Balooch, Mehdi; Fehring, Jr., Edward J.; Schildbach, Marcus A.

    2000-01-01

    Generation of low work function, stable compound thin films by laser ablation. Compound thin films with low work function can be synthesized by simultaneously laser ablating silicon, for example, and thermal evaporating an alkali metal into an oxygen environment. For example, the compound thin film may be composed of Si/Cs/O. The work functions of the thin films can be varied by changing the silicon/alkali metal/oxygen ratio. Low work functions of the compound thin films deposited on silicon substrates were confirmed by ultraviolet photoelectron spectroscopy (UPS). The compound thin films are stable up to 500.degree. C. as measured by x-ray photoelectron spectroscopy (XPS). Tests have established that for certain chemical compositions and annealing temperatures of the compound thin films, negative electron affinity (NEA) was detected. The low work function, stable compound thin films can be utilized in solar cells, field emission flat panel displays, electron guns, and cold cathode electron guns.

  9. Density functional theory for carbon dioxide crystal

    SciTech Connect (OSTI)

    Chang, Yiwen; Mi, Jianguo Zhong, Chongli

    2014-05-28

    We present a density functional approach to describe the solid?liquid phase transition, interfacial and crystal structure, and properties of polyatomic CO{sub 2}. Unlike previous phase field crystal model or density functional theory, which are derived from the second order direct correlation function, the present density functional approach is based on the fundamental measure theory for hard-sphere repulsion in solid. More importantly, the contributions of enthalpic interactions due to the dispersive attractions and of entropic interactions arising from the molecular architecture are integrated in the density functional model. Using the theoretical model, the predicted liquid and solid densities of CO{sub 2} at equilibrium triple point are in good agreement with the experimental values. Based on the structure of crystal-liquid interfaces in different planes, the corresponding interfacial tensions are predicted. Their respective accuracies need to be tested.

  10. Supervisory Essentials: Strategies for Success!

    Broader source: Energy.gov [DOE]

    Couse Description:  This course is designed to assist new first-line supervisors in developing the competencies they need to achieve their primary responsibilities, some of which include:...

  11. Structure-Assisted Functional Anchor Implantation in Robust Metal...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structure-Assisted Functional Anchor Implantation in Robust Metal-Organic Frameworks with ... functionality was performed to the functionalized framework via a click reaction. ...

  12. Functional electrolyte for lithium-ion batteries (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    Data Explorer Search Results Functional electrolyte for lithium-ion batteries Title: Functional electrolyte for lithium-ion batteries Functional electrolyte solvents include ...

  13. Weak measurement and Bohmian conditional wave functions

    SciTech Connect (OSTI)

    Norsen, Travis; Struyve, Ward

    2014-11-15

    It was recently pointed out and demonstrated experimentally by Lundeen etal. that the wave function of a particle (more precisely, the wave function possessed by each member of an ensemble of identically-prepared particles) can be directly measured using weak measurement. Here it is shown that if this same technique is applied, with appropriate post-selection, to one particle from a perhaps entangled multi-particle system, the result is precisely the so-called conditional wave function of Bohmian mechanics. Thus, a plausibly operationalist method for defining the wave function of a quantum mechanical sub-system corresponds to the natural definition of a sub-system wave function which Bohmian mechanics uniquely makes possible. Similarly, a weak-measurement-based procedure for directly measuring a sub-systems density matrix should yield, under appropriate circumstances, the Bohmian conditional density matrix as opposed to the standard reduced density matrix. Experimental arrangements to demonstrate this behaviorand also thereby reveal the non-local dependence of sub-system state functions on distant interventionsare suggested and discussed. - Highlights: We study a direct measurement protocol for wave functions and density matrices. Weakly measured states of entangled particles correspond to Bohmian conditional states. Novel method of observing quantum non-locality is proposed.

  14. All-SiC Inductively Coupled Charger with Integrated Plug-in and Boost Functionalities for PEV Applications

    SciTech Connect (OSTI)

    Chinthavali, Madhu Sudhan; Campbell, Steven L; Tolbert, Leon M

    2016-01-01

    So far, vehicular power electronics integration is limited to the integration of on-board battery chargers (OBC) into the traction drive system and sometimes to the accessory dc/dc converters in plug-in electric vehicles (PEV). These integration approaches do not provide isolation from the grid although it is an important feature that is required for user interface systems that have grid connections. This is therefore a major limitation that needs to be addressed along with the integrated functionality. Furthermore, there is no previous study that proposes the integration of wireless charger with the other on-board components. This study features a unique way of combining the wired and wireless charging functionalities with vehicle side boost converter integration and maintaining the isolation to provide the best solution to the plug-in electric vehicle users. The new topology is additionally compared with commercially available OBC systems from manufacturers.

  15. Proton structure functions at small x

    SciTech Connect (OSTI)

    Hentschinski, Martin

    2015-01-01

    Proton structure functions are measured in electron-proton collision through inelastic scattering of virtual photons with virtuality Q on protons; x denotes the momentum fraction carried by the struck parton. Proton structure functions are currently described with excellent accuracy in terms of scale dependent parton distribution functions, defined in terms of collinear factorization and DGLAP evolution in Q. With decreasing x however, parton densities increase and are ultimately expected to saturate. In this regime DGLAP evolution will finally break down and non-linear evolution equations w.r.t x are expected to take over. In the first part of the talk we present recent result on an implementation of physical DGLAP evolution. Unlike the conventional description in terms of parton distribution functions, the former describes directly the Q dependence of the measured structure functions. It is therefore physical insensitive to factorization scheme and scale ambiguities. It therefore provides a more stringent test of DGLAP evolution and eases the manifestation of (non-linear) small x effects. It however requires a precise measurement of both structure functions F2 and FL, which will be only possible at future facilities, such as an Electron Ion Collider. In the second part we present a recent analysis of the small x region of the combined HERA data on the structure function F2. We demonstrate that (linear) next-to-leading order BFKL evolution describes the effective Pomeron intercept, determined from the combined HERA data, once a resummation of collinear enhanced terms is included and the renormalization scale is fixed using the BLM optimal scale setting procedure. We also provide a detailed description of the Q and x dependence of the full structure functions F2 in the small x region, as measured at HERA. As a result, predictions for the structure function FL are found to be in agreement with the existing HERA

  16. Proton structure functions at small x

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hentschinski, Martin

    2015-01-01

    Proton structure functions are measured in electron-proton collision through inelastic scattering of virtual photons with virtuality Q on protons; x denotes the momentum fraction carried by the struck parton. Proton structure functions are currently described with excellent accuracy in terms of scale dependent parton distribution functions, defined in terms of collinear factorization and DGLAP evolution in Q. With decreasing x however, parton densities increase and are ultimately expected to saturate. In this regime DGLAP evolution will finally break down and non-linear evolution equations w.r.t x are expected to take over. In the first part of the talk we present recentmore » result on an implementation of physical DGLAP evolution. Unlike the conventional description in terms of parton distribution functions, the former describes directly the Q dependence of the measured structure functions. It is therefore physical insensitive to factorization scheme and scale ambiguities. It therefore provides a more stringent test of DGLAP evolution and eases the manifestation of (non-linear) small x effects. It however requires a precise measurement of both structure functions F2 and FL, which will be only possible at future facilities, such as an Electron Ion Collider. In the second part we present a recent analysis of the small x region of the combined HERA data on the structure function F2. We demonstrate that (linear) next-to-leading order BFKL evolution describes the effective Pomeron intercept, determined from the combined HERA data, once a resummation of collinear enhanced terms is included and the renormalization scale is fixed using the BLM optimal scale setting procedure. We also provide a detailed description of the Q and x dependence of the full structure functions F2 in the small x region, as measured at HERA. As a result, predictions for the structure function FL are found to be in agreement with the existing HERA data.« less

  17. Surface-functionalized mesoporous carbon materials

    DOE Patents [OSTI]

    Dai, Sheng; Gorka, Joanna; Mayes, Richard T.

    2016-02-02

    A functionalized mesoporous carbon composition comprising a mesoporous carbon scaffold having mesopores in which polyvinyl polymer grafts are covalently attached, wherein said mesopores have a size of at least 2 nm and up to 50 nm. Also described is a method for producing the functionalized mesoporous composition, wherein a reaction medium comprising a precursor mesoporous carbon, vinyl monomer, initiator, and solvent is subjected to sonication of sufficient power to result in grafting and polymerization of the vinyl monomer into mesopores of the precursor mesoporous carbon. Also described are methods for using the functionalized mesoporous carbon, particularly in extracting metal ions from metal-containing solutions.

  18. Loop expansion in a functional space

    SciTech Connect (OSTI)

    Kroger, H.; Labelle, P.

    1989-07-15

    As an alternative to the loop expansion of the effective potential, wesuggest a functional expansion of the generating functional for an/ital n/-point Euclidean Green's function. The formulation of the scheme isindependent of the space-time dimension of the model. The scheme yieldsstandard perturbation theory in the regime of a small coupling constant andallows to extract information on the regime of strong coupling. As an explicitexample we consider the scalar /Phi//sup 4/ model and computecontributions up to the four-loop level.

  19. Analytic cubic and quartic force fields using density-functional theory

    SciTech Connect (OSTI)

    Ringholm, Magnus; Gao, Bin; Thorvaldsen, Andreas J.; Ruud, Kenneth; Jonsson, Dan; High Performance Computing Group, University of Tromsø—The Arctic University of Norway, 9037 Tromsø ; Bast, Radovan; Ekström, Ulf; Helgaker, Trygve

    2014-01-21

    We present the first analytic implementation of cubic and quartic force constants at the level of Kohn–Sham density-functional theory. The implementation is based on an open-ended formalism for the evaluation of energy derivatives in an atomic-orbital basis. The implementation relies on the availability of open-ended codes for evaluation of one- and two-electron integrals differentiated with respect to nuclear displacements as well as automatic differentiation of the exchange–correlation kernels. We use generalized second-order vibrational perturbation theory to calculate the fundamental frequencies of methane, ethane, benzene, and aniline, comparing B3LYP, BLYP, and Hartree–Fock results. The Hartree–Fock anharmonic corrections agree well with the B3LYP corrections when calculated at the B3LYP geometry and from B3LYP normal coordinates, suggesting that the inclusion of electron correlation is not essential for the reliable calculation of cubic and quartic force constants.

  20. First Measurement of the {rho} Spectral Function in High-Energy Nuclear Collisions

    SciTech Connect (OSTI)

    Arnaldi, R.; Colla, A.; Cortese, P.; Ferretti, A.; Oppedisano, C.; Scomparin, E.; Averbeck, R.; Drees, A.; Banicz, K.; Specht, H.J.; Castor, J.; Devaux, A.; Fargeix, J.; Force, P.; Manso, F.; Chaurand, B.; Cicalo, C.; De Falco, A.; Floris, M.; Masoni, A.

    2006-04-28

    We report on a precision measurement of low-mass muon pairs in 158 AGeV indium-indium collisions at the CERN SPS. A significant excess of pairs is observed above the yield expected from neutral meson decays. The unprecedented sample size of 360 000 dimuons and the good mass resolution of about 2% allow us to isolate the excess by subtraction of the decay sources. The shape of the resulting mass spectrum is consistent with a dominant contribution from {pi}{sup +}{pi}{sup -}{yields}{rho}{yields}{mu}{sup +}{mu}{sup -} annihilation. The associated space-time averaged {rho} spectral function shows a strong broadening, but essentially no shift in mass. This may rule out theoretical models linking hadron masses directly to the chiral condensate.

  1. Clinical Validation of 4-Dimensional Computed Tomography Ventilation With Pulmonary Function Test Data

    SciTech Connect (OSTI)

    Brennan, Douglas; Schubert, Leah; Diot, Quentin; Castillo, Richard; Castillo, Edward; Guerrero, Thomas; Martel, Mary K.; Linderman, Derek; Gaspar, Laurie E.; Miften, Moyed; Kavanagh, Brian D.; Vinogradskiy, Yevgeniy

    2015-06-01

    Purpose: A new form of functional imaging has been proposed in the form of 4-dimensional computed tomography (4DCT) ventilation. Because 4DCTs are acquired as part of routine care for lung cancer patients, calculating ventilation maps from 4DCTs provides spatial lung function information without added dosimetric or monetary cost to the patient. Before 4DCT-ventilation is implemented it needs to be clinically validated. Pulmonary function tests (PFTs) provide a clinically established way of evaluating lung function. The purpose of our work was to perform a clinical validation by comparing 4DCT-ventilation metrics with PFT data. Methods and Materials: Ninety-eight lung cancer patients with pretreatment 4DCT and PFT data were included in the study. Pulmonary function test metrics used to diagnose obstructive lung disease were recorded: forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity. Four-dimensional CT data sets and spatial registration were used to compute 4DCT-ventilation images using a density change–based and a Jacobian-based model. The ventilation maps were reduced to single metrics intended to reflect the degree of ventilation obstruction. Specifically, we computed the coefficient of variation (SD/mean), ventilation V20 (volume of lung ≤20% ventilation), and correlated the ventilation metrics with PFT data. Regression analysis was used to determine whether 4DCT ventilation data could predict for normal versus abnormal lung function using PFT thresholds. Results: Correlation coefficients comparing 4DCT-ventilation with PFT data ranged from 0.63 to 0.72, with the best agreement between FEV1 and coefficient of variation. Four-dimensional CT ventilation metrics were able to significantly delineate between clinically normal versus abnormal PFT results. Conclusions: Validation of 4DCT ventilation with clinically relevant metrics is essential. We demonstrate good global agreement between PFTs and 4DCT-ventilation, indicating that 4DCT

  2. Dipole rescattering and the nuclear structure function

    SciTech Connect (OSTI)

    Carvalho, F.; Goncalves, V. P.; Navarra, F. S.; Oliveira, E. G.

    2013-03-25

    In the framework of the dipole model, we study the effects of the dipole multiple scatterings in a nuclear target and compute the nuclear structure function. We compare different unitarization schemes and confront our results with the E665 data.

  3. Physicochemically functional ultrathin films by interfacial polymerization

    DOE Patents [OSTI]

    Lonsdale, Harold K.; Babcock, Walter C.; Friensen, Dwayne T.; Smith, Kelly L.; Johnson, Bruce M.; Wamser, Carl C.

    1990-01-01

    Interfacially-polymerized ultrathin films containing physicochemically functional groups are disclosed, both with and without supports. Various applications are disclsoed, including membrane electrodes, selective membranes and sorbents, biocompatible materials, targeted drug delivery, and narrow band optical absorbers.

  4. Physicochemically functional ultrathin films by interfacial polymerization

    DOE Patents [OSTI]

    Lonsdale, H.K.; Babcock, W.C.; Friensen, D.T.; Smith, K.L.; Johnson, B.M.; Wamser, C.C.

    1990-08-14

    Interfacially-polymerized ultrathin films containing physicochemically functional groups are disclosed, both with and without supports. Various applications are disclosed, including membrane electrodes, selective membranes and sorbents, biocompatible materials, targeted drug delivery, and narrow band optical absorbers. 3 figs.

  5. Crystallization and functionality of inorganic materials

    SciTech Connect (OSTI)

    Xue, Dongfeng, E-mail: dongfeng@ciac.jl.cn [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China) [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); School of Chemical Engineering, Dalian University of Technology, Dalian 116024 (China); Li, Keyan [School of Chemical Engineering, Dalian University of Technology, Dalian 116024 (China)] [School of Chemical Engineering, Dalian University of Technology, Dalian 116024 (China); Liu, Jun [Key Laboratory of Low Dimensional Materials and Application Technology, Ministry of Education, Faculty of Materials, Optoelectronics and Physics, Xiangtan University, 411105 (China)] [Key Laboratory of Low Dimensional Materials and Application Technology, Ministry of Education, Faculty of Materials, Optoelectronics and Physics, Xiangtan University, 411105 (China); Sun, Congting; Chen, Kunfeng [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China) [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); School of Chemical Engineering, Dalian University of Technology, Dalian 116024 (China)

    2012-10-15

    In this article, we briefly summarized our recent work on the studies of crystallization and functionality of inorganic materials. On the basis of the chemical bonding theory of single crystal growth, we can quantitatively simulate Cu{sub 2}O crystallization processes in solution system. We also kinetically controlled Cu{sub 2}O crystallization process in the reduction solution route. Lithium ion battery and supercapacitor performances of some oxides such as Co{sub 3}O{sub 4} and MnO{sub 2} were shown to elucidate the important effect of crystallization on functionality of inorganic materials. This work encourages us to create novel functionalities through the study of crystallization of inorganic materials, which warrants more chances in the field of functional materials.

  6. Parallel 3D Fast Fourier Transform Functions

    Energy Science and Technology Software Center (OSTI)

    2008-12-19

    BigFFT is a scalable implementation of a three dimensional Fast Fourier Transform operation. Functions are included for forward and backward real-to-complex 3D transforms.

  7. Sequential Linker Installation: Precise Placement of Functional...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    developed to construct multivariate MOFs with functional groups precisely positioned. PCN-700, a Zr-MOF with eight-connected Zr6O4(OH)8(H2O)4 clusters, has been judiciously...

  8. MDF Form and Function (Text Version)

    Broader source: Energy.gov [DOE]

    This is a text version of the Manufacturing Demonstration Facilities (MDF) Form and Function video, originally presented on March 12, 2012 at the MDF Workshop held in Chicago, Illinois.

  9. Safety Management Functions, Responsibilities, and Authorities Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1997-10-08

    This Manual defines safety management functions, responsibilities, and authorities for DOE senior management with responsibilities for line, support, oversight, and enforcement actions. Canceled by DOE M 411.1-1A. Does not cancel other directives.

  10. Emergency Support Function #12; Energy Annex

    Broader source: Energy.gov [DOE]

    Emergency Support Function (ESF) #12 – Energy is intended to facilitate the restoration of damaged energy systems and components when activated by the Secretary of Homeland Security for incidents...

  11. Critical Assessment of Function Annotation Meeting, 2011

    SciTech Connect (OSTI)

    Friedberg, Iddo

    2015-01-21

    The Critical Assessment of Function Annotation meeting was held July 14-15, 2011 at the Austria Conference Center in Vienna, Austria. There were 73 registered delegates at the meeting. We thank the DOE for this award. It helped us organize and support a scientific meeting AFP 2011 as a special interest group (SIG) meeting associated with the ISMB 2011 conference. The conference was held in Vienna, Austria, in July 2011. The AFP SIG was held on July 15-16, 2011 (immediately preceding the conference). The meeting consisted of two components, the first being a series of talks (invited and contributed) and discussion sections dedicated to protein function research, with an emphasis on the theory and practice of computational methods utilized in functional annotation. The second component provided a large-scale assessment of computational methods through participation in the Critical Assessment of Functional Annotation (CAFA).

  12. Subtask 5: Functional nanostructured transparent electrode materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5: Functional nanostructured transparent electrode materials All papers by year Subtask 1 Subtask 2 Subtask 3 Subtask 4 Subtask 5 Jeon, K.-W. and Seo, D.-K. (2014) Concomitant...

  13. Safety Management Functions, Responsibilities, and Authorities Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-12-31

    This Manual defines safety management functions, responsibilities, and authorities for DOE senior management with responsibilities for line, support, oversight, and enforcement actions. Cancels DOE M 411.1-1B. Canceled by DOE O 450.2.

  14. 6.20 Mapping Human Brain Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 612011 6.20 Mapping Human Brain Function Many mysteries of the human brain have been unraveled by positron emission tomography (PET), an imaging tool used worldwide to diagnose ...

  15. Structural and functional studies of conserved nucleotide-binding protein LptB in lipopolysaccharide transport

    SciTech Connect (OSTI)

    Wang, Zhongshan; Xiang, Quanju; Zhu, Xiaofeng; Dong, Haohao; He, Chuan; Wang, Haiyan; Zhang, Yizheng; Wang, Wenjian; Dong, Changjiang

    2014-09-26

    Highlights: • Determination of the structure of the wild-type LptB in complex with ATP and Mg{sup 2+}. • Demonstrated that ATP binding residues are essential for LptB’s ATPase activity and LPS transport. • Dimerization is required for the LptB’s function and LPS transport. • Revealed relationship between activity of the LptB and the vitality of E. coli cells. - Abstract: Lipopolysaccharide (LPS) is the main component of the outer membrane of Gram-negative bacteria, which plays an essential role in protecting the bacteria from harsh conditions and antibiotics. LPS molecules are transported from the inner membrane to the outer membrane by seven LPS transport proteins. LptB is vital in hydrolyzing ATP to provide energy for LPS transport, however this mechanism is not very clear. Here we report wild-type LptB crystal structure in complex with ATP and Mg{sup 2+}, which reveals that its structure is conserved with other nucleotide-binding proteins (NBD). Structural, functional and electron microscopic studies demonstrated that the ATP binding residues, including K42 and T43, are crucial for LptB’s ATPase activity, LPS transport and the vitality of Escherichia coli cells with the exceptions of H195A and Q85A; the H195A mutation does not lower its ATPase activity but impairs LPS transport, and Q85A does not alter ATPase activity but causes cell death. Our data also suggest that two protomers of LptB have to work together for ATP hydrolysis and LPS transport. These results have significant impacts in understanding the LPS transport mechanism and developing new antibiotics.

  16. Structure functions and intrinsic quark orbital motion

    SciTech Connect (OSTI)

    Zavada, Petr

    2007-06-13

    Covariant version of the quark model is studied. It is shown how the polarized and unpolarized structure functions depend on the quark intrinsic motion. The important role of the quark orbital momentum, by which the intrinsic motion is generated, appears as a direct consequence of the covariant description. At the same time, the procedure for obtaining 3D quark momentum distribution from the structure functions is suggested.

  17. Density-dependent covariant energy density functionals

    SciTech Connect (OSTI)

    Lalazissis, G. A.

    2012-10-20

    Relativistic nuclear energy density functionals are applied to the description of a variety of nuclear structure phenomena at and away fromstability line. Isoscalar monopole, isovector dipole and isoscalar quadrupole giant resonances are calculated using fully self-consistent relativistic quasiparticle randomphase approximation, based on the relativistic Hartree-Bogoliubovmodel. The impact of pairing correlations on the fission barriers in heavy and superheavy nuclei is examined. The role of pion in constructing desnity functionals is also investigated.

  18. Translocator Protein Structure and Function | Stanford Synchrotron

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radiation Lightsource Translocator Protein Structure and Function Monday, November 30, 2015 Translocator protein (TSPO) is an ancient conserved protein whose functions in bacteria and higher eukaryotes are yet to be clearly defined in spite of more than 30 years of study. In mitochondria, it was first recognized as an outer membrane protein that binds benzodiazepine drugs, but distinct from the central nervous system site, the GABAA receptor(1). Originally called the peripheral

  19. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Peptoid Nanosheets Offer a Diversity of Functionalities Print Wednesday, 29 April 2015 00:00 Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to

  20. Extraction of Transversity and Collins Functions

    SciTech Connect (OSTI)

    Anselmino, Mauro; Boglione, Mariaelena; D'Alesio, Umberto; Melis, Stefano; Murgia, Francesco; Prokudin, Alexei

    2014-01-01

    We present a global re-analysis of recent experimental data on azimuthal asymmetries in semi-inclusive deep inelastic scattering, from the HERMES and COMPASS Collaborations, and in e{sup +}e{sup -} --> h_1h_2X processes, from the Belle Collaboration. The transversity distribution and the Collins functions are extracted simultaneously, in a revised analysis which also takes into account a new parameterization of the unknown functions.

  1. The geometry of electron wave functions

    SciTech Connect (OSTI)

    Aminov, Yurii A

    2013-02-28

    To each wave function we assign a codimension-two submanifold in Euclidean space. We study the case of the wave function of a single electron in the hydrogen atom or other hydrogen-type atoms with quantum numbers n, l, m in detail. We prove theorems describing the behaviour of the scalar and sectional curvature of the constructed submanifold, depending on the quantum numbers. We also consider the external geometry of the submanifold. Bibliography: 9 titles.

  2. Electroweak fragmentation functions for dark matter annihilation

    SciTech Connect (OSTI)

    Cavasonza, Leila Ali; Krämer, Michael; Pellen, Mathieu

    2015-02-18

    Electroweak corrections can play a crucial role in dark matter annihilation. The emission of gauge bosons, in particular, leads to a secondary flux consisting of all Standard Model particles, and may be described by electroweak fragmentation functions. To assess the quality of the fragmentation function approximation to electroweak radiation in dark matter annihilation, we have calculated the flux of secondary particles from gauge-boson emission in models with Majorana fermion and vector dark matter, respectively. For both models, we have compared cross sections and energy spectra of positrons and antiprotons after propagation through the galactic halo in the fragmentation function approximation and in the full calculation. Fragmentation functions fail to describe the particle fluxes in the case of Majorana fermion annihilation into light fermions: the helicity suppression of the lowest-order cross section in such models cannot be lifted by the leading logarithmic contributions included in the fragmentation function approach. However, for other classes of models like vector dark matter, where the lowest-order cross section is not suppressed, electroweak fragmentation functions provide a simple, model-independent and accurate description of secondary particle fluxes.

  3. When Function Follows Form: Plastic Solar Cells | ANSER Center...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    When Function Follows Form: Plastic Solar Cells Home > Research > ANSER Research Highlights > When Function Follows Form: Plastic Solar Cells...

  4. Essential roles of protein-solvent many-body correlation in solvent-entropy effect on protein folding and denaturation: Comparison between hard-sphere solvent and water

    SciTech Connect (OSTI)

    Oshima, Hiraku; Kinoshita, Masahiro

    2015-04-14

    In earlier works, we showed that the entropic effect originating from the translational displacement of water molecules plays the pivotal role in protein folding and denaturation. The two different solvent models, hard-sphere solvent and model water, were employed in theoretical methods wherein the entropic effect was treated as an essential factor. However, there were similarities and differences in the results obtained from the two solvent models. In the present work, to unveil the physical origins of the similarities and differences, we simultaneously consider structural transition, cold denaturation, and pressure denaturation for the same protein by employing the two solvent models and considering three different thermodynamic states for each solvent model. The solvent-entropy change upon protein folding/unfolding is decomposed into the protein-solvent pair (PA) and many-body (MB) correlation components using the integral equation theories. Each component is further decomposed into the excluded-volume (EV) and solvent-accessible surface (SAS) terms by applying the morphometric approach. The four physically insightful constituents, (PA, EV), (PA, SAS), (MB, EV), and (MB, SAS), are thus obtained. Moreover, (MB, SAS) is discussed by dividing it into two factors. This all-inclusive investigation leads to the following results: (1) the protein-water many-body correlation always plays critical roles in a variety of folding/unfolding processes; (2) the hard-sphere solvent model fails when it does not correctly reproduce the protein-water many-body correlation; (3) the hard-sphere solvent model becomes problematic when the dependence of the many-body correlation on the solvent number density and temperature is essential: it is not quite suited to studies on cold and pressure denaturating of a protein; (4) when the temperature and solvent number density are limited to the ambient values, the hard-sphere solvent model is usually successful; and (5) even at the ambient

  5. Functionalization of polymer powders for SLS-processes using an atmospheric plasma jet in a fluidized bed reactor

    SciTech Connect (OSTI)

    Sachs, Marius; Schmitt, Adeliene; Schmidt, Jochen; Peukert, Wolfgang; Wirth, Karl-Ernst

    2015-05-22

    Recently additive manufacturing processes such as selective laser sintering (SLS) of polymers have gained more importance for industrial applications [1]. Tailor-made modification of polymers is essential in order to make these processes more efficient and to cover the industrial demands. The so far used polymer materials show weak performance regarding the mechanical stability of processed parts. To overcome this limitation, a new route to functionalize the surface of commercially available polymer particles (PA12; PE-HD; PP) using an atmospheric plasma jet in combination with a fluidized bed reactor has been investigated. Consequently, an improvement of adhesion and wettability [2] of the polymer surface without restraining the bulk properties of the powder is achieved. The atmospheric plasma jet process can provide reactive species at moderate temperatures which are suitable for polymer material. The functionalization of the polymer powders improves the quality of the devices build in a SLS-process.

  6. Coulomb wave functions in momentum space

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Eremenko, V; Upadhyay, N. J.; Thompson, I J; Elster, Charlotte; Nunes, F. M.; Arbanas, Goran; Escher, J.E.; Hlophe, L.

    2015-01-01

    An algorithm to calculate non-relativistic partial-wave Coulomb functions in momentum space is presented. The arguments are the Sommerfeld parameter eta, the angular momentum l, the asymptotic momentum q and the 'running' momentum p, where both momenta are real. Since the partial-wave Coulomb functions exhibit singular behavior when p -> q, different representations of the Legendre functions of the 2nd kind need to be implemented in computing the functions for the values of p close to the singularity and far away from it. The code for the momentum-space Coulomb wave functions is applicable for values of vertical bar eta vertical barmore » in the range of 10(-1) to 10, and thus is particularly suited for momentum space calculations of nuclear reactions. Program Summary Program title: libcwfn Catalogue identifier: AEUQ_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEUQ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 864503 No. of bytes in distributed program, including test data, etc.: 7178021 Distribution format: tar.gz Programming language: Fortran 90, Fortran 77, Python, make (GNU Make dialect), GNU Bash shell interpreter (available as /bin/bash). Computer: Apple Powermac (Intel Xeon), ASUS K53U (AMD E-350 (Dual Core)), DELL Precision T3500 (Intel Xeon), NERSC Carver (Intel Nehalem Quad Core). Operating system: Linux, Windows (using Cygwin). RAM: less than 512 Mbytes Classification: 17.8, 17.13, 17.16. Nature of problem: The calculation of partial wave Coulomb functions with integer land all other arguments real. Solution method: Computing the value of the function using explicit formulae and algorithms. Running time: Less than 10(-3) s. (C) 2014 Elsevier B.V. All rights reserved.« less

  7. Coulomb wave functions in momentum space

    SciTech Connect (OSTI)

    Eremenko, V; Upadhyay, N. J.; Thompson, I J; Elster, Charlotte; Nunes, F. M.; Arbanas, Goran; Escher, J.E.; Hlophe, L.

    2015-01-01

    An algorithm to calculate non-relativistic partial-wave Coulomb functions in momentum space is presented. The arguments are the Sommerfeld parameter eta, the angular momentum l, the asymptotic momentum q and the 'running' momentum p, where both momenta are real. Since the partial-wave Coulomb functions exhibit singular behavior when p -> q, different representations of the Legendre functions of the 2nd kind need to be implemented in computing the functions for the values of p close to the singularity and far away from it. The code for the momentum-space Coulomb wave functions is applicable for values of vertical bar eta vertical bar in the range of 10(-1) to 10, and thus is particularly suited for momentum space calculations of nuclear reactions. Program Summary Program title: libcwfn Catalogue identifier: AEUQ_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEUQ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 864503 No. of bytes in distributed program, including test data, etc.: 7178021 Distribution format: tar.gz Programming language: Fortran 90, Fortran 77, Python, make (GNU Make dialect), GNU Bash shell interpreter (available as /bin/bash). Computer: Apple Powermac (Intel Xeon), ASUS K53U (AMD E-350 (Dual Core)), DELL Precision T3500 (Intel Xeon), NERSC Carver (Intel Nehalem Quad Core). Operating system: Linux, Windows (using Cygwin). RAM: less than 512 Mbytes Classification: 17.8, 17.13, 17.16. Nature of problem: The calculation of partial wave Coulomb functions with integer land all other arguments real. Solution method: Computing the value of the function using explicit formulae and algorithms. Running time: Less than 10(-3) s. (C) 2014 Elsevier B.V. All rights reserved.

  8. Identification of amino-acid residues in the V protein of peste des petits ruminants essential for interference and suppression of STAT-mediated interferon signaling

    SciTech Connect (OSTI)

    Ma, Xusheng; Yang, Xing; Nian, Xiaofeng; Zhang, Zhidong; Dou, Yongxi; Zhang, Xuehu; Luo, Xuenong; Su, Junhong; Zhu, Qiyun; Cai, Xuepeng

    2015-09-15

    Peste des petits ruminants virus (PPRV) causes a fatal disease in small ruminants. V protein of PPRV plays a pivotal role in interfering with host innate immunity by blocking IFNs signaling through interacting with STAT1 and STAT2. In the present study, the results demonstrated that PPRV V protein blocks IFN actions in a dose dependent manner and restrains the translocation of STAT1/2 proteins. We speculate that the translocation inhibition might be caused by the interfering of the downstream of STAT protein. Mutagenesis defines that Cys cluster and Trp motif of PPRV V protein are essential for STAT-mediated IFN signaling. These findings give a new sight for the further studies to understand the delicate mechanism of PPRV to escape the IFN signaling. - Highlights: • PPRV V protein inhibits type I IFN production and blocks its activation. • PPRV V protein negatively regulates activation of ISRE and GAS promoter. • PPRV V protein inhibits nuclear translocation of STAT protein by non-degradation. • PNT and VCT domain of PPRV V protein inhibit IFN transduction. • PPRV V protein binds with STAT protein via some conserved motifs.

  9. HTGR Industrial Application Functional and Operational Requirements

    SciTech Connect (OSTI)

    L. E. Demick

    2010-08-01

    This document specifies the functional and performance requirements to be used in the development of the conceptual design of a high temperature gas-cooled reactor (HTGR) based plant supplying energy to a typical industrial facility. These requirements were developed from collaboration with industry and HTGR suppliers over the preceding three years to identify the energy needs of industrial processes for which the HTGR technology is technically and economically viable. The functional and performance requirements specified herein are an effective representation of the industrial sector energy needs and an effective basis for developing a conceptual design of the plant that will serve the broadest range of industrial applications.

  10. Method of making low work function component

    DOE Patents [OSTI]

    Robinson, Vance; Weaver, Stanton Earl; Michael, Joseph Darryl

    2011-11-15

    A method for fabricating a component is disclosed. The method includes: providing a member having an effective work function of an initial value, disposing a sacrificial layer on a surface of the member, disposing a first agent within the member to obtain a predetermined concentration of the agent at said surface of the member, annealing the member, and removing the sacrificial layer to expose said surface of the member, wherein said surface has a post-process effective work function that is different from the initial value.

  11. Optically transparent and environmentally durable superhydrophobic coating based on functionalized SiO2 nanoparticles

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Schaeffer, Daniel A.; Polizos, Georgios; Smith, D. Barton; Lee, Dominic F.; Hunter, Scott R.; Datskos, Panos G.

    2015-01-09

    Optical surfaces such as mirrors and windows that are exposed to outdoor environmental conditions are susceptible to dust buildup and water condensation. The application of transparent superhydrophobic coatings on optical surfaces can improve outdoor performance via a self-cleaning effect similar to the Lotus effect. The contact angle (CA) of water droplets on a typical hydrophobic flat surface varies from 100° to 120°. Adding roughness or microtexture to a hydrophobic surface leads to an enhancement of hydrophobicity and the CA can be increased to a value in the range of 16≥0° to 175°. This result is remarkable because such behavior cannotmore » be explained using surface chemistry alone. When surface features are on the order of 100 nm or smaller, surfaces exhibit superhydrophobic behavior and maintain their optical transparency. In this work we discuss our results on transparent superhydrophobic coatings that can be applied across large surface areas. We have used functionalized silica nanoparticles to coat various optical elements and have measured the contact angle and optical transmission between 190 to 1100 nm on these elements. The functionalized silica nanoparticles were dissolved in a solution of the solvents isopropyl alcohol and 4-chlorobenzotrifluoride (PCBTF) and a proprietary ceramic binder (Cerakote ). Finally, this solution was spin-coated onto a variety of test glass substrates, and following a curing period of about 30 minutes, these coatings exhibited superhydrophobic behavior with a static CA ≥160°.« less

  12. Long-range corrected density functional theory with accelerated Hartree-Fock exchange integration using a two-Gaussian operator [LC-ωPBE(2Gau)

    SciTech Connect (OSTI)

    Song, Jong-Won; Hirao, Kimihiko

    2015-10-14

    Since the advent of hybrid functional in 1993, it has become a main quantum chemical tool for the calculation of energies and properties of molecular systems. Following the introduction of long-range corrected hybrid scheme for density functional theory a decade later, the applicability of the hybrid functional has been further amplified due to the resulting increased performance on orbital energy, excitation energy, non-linear optical property, barrier height, and so on. Nevertheless, the high cost associated with the evaluation of Hartree-Fock (HF) exchange integrals remains a bottleneck for the broader and more active applications of hybrid functionals to large molecular and periodic systems. Here, we propose a very simple yet efficient method for the computation of long-range corrected hybrid scheme. It uses a modified two-Gaussian attenuating operator instead of the error function for the long-range HF exchange integral. As a result, the two-Gaussian HF operator, which mimics the shape of the error function operator, reduces computational time dramatically (e.g., about 14 times acceleration in C diamond calculation using periodic boundary condition) and enables lower scaling with system size, while maintaining the improved features of the long-range corrected density functional theory.

  13. PrP{sup C} displays an essential protective role from oxidative stress in an astrocyte cell line derived from PrP{sup C} knockout mice

    SciTech Connect (OSTI)

    Bertuchi, Fernanda R.; Bourgeon, Dominique M.G.; Landemberger, Michele C.; Martins, Vilma R.; Cerchiaro, Giselle

    2012-02-03

    Highlights: Black-Right-Pointing-Pointer PrP{sup C} in solution acts as a radical scavenger. Black-Right-Pointing-Pointer PrP{sup C} reduces hydrogen peroxide toxicity in astrocytes. Black-Right-Pointing-Pointer Increase in ROS disrupted the cell cycle in the PrP{sup C}-knockout astrocytes. Black-Right-Pointing-Pointer PrP{sup C} prevents the cell death independently of an SOD-like activity. -- Abstract: The PrP{sup C} protein, which is especially present in the cellular membrane of nervous system cells, has been extensively studied for its controversial antioxidant activity. In this study, we elucidated the free radical scavenger activity of purified murine PrP{sup C} in solution and its participation as a cell protector in astrocytes that were subjected to treatment with an oxidant. In vitro and using an EPR spin-trapping technique, we observed that PrP{sup C} decreased the oxidation of the DMPO trap in a Fenton reaction system (Cu{sup 2+}/ascorbate/H{sub 2}O{sub 2}), which was demonstrated by approximately 70% less DMPO/OH{sup {center_dot}}. In cultured PrP{sup C}-knockout astrocytes from mice, the absence of PrP{sup C} caused an increase in intracellular ROS (reactive oxygen species) generation during the first 3 h of H{sub 2}O{sub 2} treatment. This rapid increase in ROS disrupted the cell cycle in the PrP{sup C}-knockout astrocytes, which increased the population of cells in the sub-G1 phase when compared with cultured wild-type astrocytes. We conclude that PrP{sup C} in solution acts as a radical scavenger, and in astrocytes, it is essential for protection from oxidative stress caused by an external chemical agent, which is a likely condition in human neurodegenerative CNS disorders and pathological conditions such as ischemia.

  14. Photon structure function at small x

    SciTech Connect (OSTI)

    Gluck, M.; Reya, E.; Schienbein, I.

    2001-07-01

    It is shown that recent small-x measurements of the photon structure function F{sub 2}{sup {gamma}}(x,Q{sup 2}) by the CERN LEP OPAL Collaboration are consistent with parameter-free QCD predictions at all presently accessible values of Q{sup 2}.

  15. Aviation Safety Officer, Functional Area Qualification Standard

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2010-01-20

    The Aviation Safety Officer FAQS establishes common functional area competency requirements for all DOE aviation safety personnel who provide assistance, or direction, guidance, oversight, or evaluation of contractor technical activities that could impact the safe operation of DOE’s facilities.

  16. Safety Management Functions, Responsibilities, and Authorities Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-10-18

    This Manual is a mechanism for implementing the Department's guiding principles established in DOE P 450.4 and the safety management functions outlined in DOE P 411.1 Cancels DOE M 411.1-1. Canceled by DOE M 411.1-1B.

  17. Liquid Observation Well (LOW) Functional Design

    SciTech Connect (OSTI)

    Paul, B.

    1995-01-04

    This document presents the Functional Design Criteria for installing Liquid Observation Wells (LOWS) into single-shell tanks containing either ferrocyanide or organic waste. The LOWs will be designed to accommodate the deployment of gamma, neutron, and electromagnetic induction probes and to interface with the existing tank structure and environment.

  18. Poly(ethyleneoxide) functionalization through alkylation

    DOE Patents [OSTI]

    Sivanandan, Kulandaivelu; Eitouni, Hany Basam; Li, Yan; Pratt, Russell Clayton

    2015-04-21

    A new and efficient method of functionalizing high molecular weight polymers through alkylation using a metal amide base is described. This novel procedure can also be used to synthesize polymer-based macro-initiators containing radical initiating groups at the chain-ends for synthesis of block copolymers.

  19. Functional Area Qualification Standard Job Task Analyses

    Broader source: Energy.gov [DOE]

    FAQS Job Task Analyses are performed on the Function Area Qualification Standards. The FAQS Job Task Analyses consists of: Developing a comprehensive list of tasks that define the job such as the duties and responsibilities which include determining their levels of importance and frequency. Identifying and evaluating competencies. Last step is evaluating linkage between job tasks and competencies.

  20. Aviation Manager Functional Area Qualification Standard

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-12-09

    The Aviation Manager FAQS establishes common functional area competency requirements for all DOE Aviation Manager personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical activities that could impact the safe operation of DOE’s defense nuclear facilities.

  1. Controlling Atomic Layer Deposition of TiO2 in Aerogels through Surface Functionalization

    SciTech Connect (OSTI)

    Ghosal, S; Baumann, T F; King, J S; Kucheyev, S; Wang, Y; Worsley, M A; Biener, J; Bent, S F; Hamza, A V

    2009-03-09

    } (n = 1-3)) has been shown to deactivate the substrate towards ZrO{sub 2}, HfO{sub 2}, ZnO, and TiO{sub 2} ALD processes (12-16). A possible mechanism for the deactivation effect is the blocking of surface functional groups, such as hydroxyl (OH) moieties, which serve as chemisorption sites for the ALD precursors and hence are essential for nucleating the deposition process. Henceforth, we shall refer to these surface functional groups as nucleation sites for the ALD process.

  2. Measurement of the neutron F2 structure function via spectator tagging with CLAS

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Baillie, N.; Tkachenko, S.; Zhang, J.; Bosted, P.; Bültmann, S.; Christy, M. E.; Fenker, H.; Griffioen, K. A.; Keppel, C. E.; Kuhn, S. E.; et al

    2012-04-01

    We report on the first measurement of the F2 structure function of the neutron from semi-inclusive scattering of electrons from deuterium, with low-momentum protons detected in the backward hemisphere. Restricting the momentum of the spectator protons to ≈< 100 MeV and their angles to ≈> 100 degrees relative to the momentum transfer allows an interpretation of the process in terms of scattering from nearly on-shell neutrons. The F2n data collected cover the nucleon resonance and deep-inelastic regions over a wide range of x for 0.65 < Q2 < 4.52 GeV2, with uncertainties from nuclear corrections estimated to be less thanmore » a few percent. These measurements provide the first determination of the neutron to proton structure function ratio F2n/F2p at 0.2 ≈< x ≈< 0.8, essentially free of nuclear corrections.« less

  3. Structure-function analysis of human protein Ero1-L{alpha}

    SciTech Connect (OSTI)

    Chu, Yanyan [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China)] [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); Yang, Charles; Chen, Xianjun; Zheng, Wenyun [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China) [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); Yang, Yi, E-mail: yiyang@ecust.edu.cn [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China) [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); Tang, Yun, E-mail: ytang234@ecust.edu.cn [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China)] [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China)

    2009-11-27

    Human Ero1-L{alpha} catalyzes the formation of disulfide bond and hence plays an essential role in protein folding. Understanding the mechanism of disulfide bond formation in mammals is important because of the involvement of protein misfolding in conditions such as diabetes, arthritis, cancer, and aging. However, the crystal structure of the enzyme is not available yet, which seriously hinders the understanding of biological function of Ero1-L{alpha}. Based on the crystal structure of yeast Ero1p, a rational three-dimensional structural model of Ero1-L{alpha} was built and the characteristics of the enzyme were hence investigated. The characteristic similarities and differences between Ero1-L{alpha} and Ero1p were compared on the basis of computational and experimental results, providing the first insight into the structure-function relationships of the enzymes. Both calculation and experiment got the concordant conclusion that FAD binds more tightly with Ero1-L{alpha} than Ero1p. In addition, the probable electron transfer pathway was proposed on the basis of the structural models.

  4. Remote sensing-based characterization of plant functional type distributions at the Barrow Environmental Observatory

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kumar, Jitendra; Hoffman, Forrest M.

    2014-03-18

    Arctic ecosystems have been observed to be warming faster than the global average and are predicted to experience accelerated changes in climate due to global warming. Arctic vegetation is particularly sensitive to warming conditions and likely to exhibit shifts in species composition, phenology and productivity under changing climate. Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral characteristics which can be harnessed to discriminate plant types and develop quantitative vegetation indices. We have combined high resolution multi-spectral remote sensing from the WorldView 2 satellite with LIDAR-derived digital elevation models to characterize the tundra landscape on the North Slope of Alaska. Classification of landscape using spectral and topographic characteristics yields spatial regions with expectedly similar vegetation characteristics. A field campaign was conducted during peak growing season to collect vegetation harvests from a number of 1m x 1m plots in the study region, which were then analyzed for distribution of vegetation types in the plots. Statistical relationships were developed between spectral and topographic characteristics and vegetation type distributions at the vegetation plots. These derived relationships were employed to statistically upscale the vegetation distributions for the landscape based on spectral characteristics. Vegetation distributions developed are being used to provide Plant Functional Type (PFT) maps for use in the Community Land Model (CLM).

  5. Remote sensing-based characterization, 2-m, Plant Functional Type Distributions, Barrow Environmental Observatory, 2010

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Zachary Langford; Forrest Hoffman; Jitendra Kumar

    Arctic ecosystems have been observed to be warming faster than the global average and are predicted to experience accelerated changes in climate due to global warming. Arctic vegetation is particularly sensitive to warming conditions and likely to exhibit shifts in species composition, phenology and productivity under changing climate. Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral characteristics which can be harnessed to discriminate plant types and develop quantitative vegetation indices. We have combined high resolution multi-spectral remote sensing from the WorldView 2 satellite with LIDAR-derived digital elevation models to characterize the tundra landscape on the North Slope of Alaska. Classification of landscape using spectral and topographic characteristics yields spatial regions with expectedly similar vegetation characteristics. A field campaign was conducted during peak growing season to collect vegetation harvests from a number of 1m x 1m plots in the study region, which were then analyzed for distribution of vegetation types in the plots. Statistical relationships were developed between spectral and topographic characteristics and vegetation type distributions at the vegetation plots. These derived relationships were employed to statistically upscale the vegetation distributions for the landscape based on spectral characteristics. Vegetation distributions developed are being used to provide Plant Functional Type (PFT) maps for use in the Community Land Model (CLM).

  6. Remote sensing-based characterization of plant functional type distributions at the Barrow Environmental Observatory

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kumar, Jitendra; Hoffman, Forrest M.

    Arctic ecosystems have been observed to be warming faster than the global average and are predicted to experience accelerated changes in climate due to global warming. Arctic vegetation is particularly sensitive to warming conditions and likely to exhibit shifts in species composition, phenology and productivity under changing climate. Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral characteristics which can be harnessed to discriminate plant types and develop quantitative vegetation indices. We have combined high resolution multi-spectral remote sensing from the WorldView 2 satellite with LIDAR-derived digital elevation models to characterize the tundra landscape on the North Slope of Alaska. Classification of landscape using spectral and topographic characteristics yields spatial regions with expectedly similar vegetation characteristics. A field campaign was conducted during peak growing season to collect vegetation harvests from a number of 1m x 1m plots in the study region, which were then analyzed for distribution of vegetation types in the plots. Statistical relationships were developed between spectral and topographic characteristics and vegetation type distributions at the vegetation plots. These derived relationships were employed to statistically upscale the vegetation distributions for the landscape based on spectral characteristics. Vegetation distributions developed are being used to provide Plant Functional Type (PFT) maps for use in the Community Land Model (CLM).

  7. Nonperturbative QCD Coupling and its $$\\beta$$-function from Light-Front Holography

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Brodskey, Stanley J.; de Teramond, Guy; Deur, Alexandre P.

    2010-05-28

    The light-front holographic mapping of classical gravity in AdS space, modified by a positive-sign dilaton background, leads to a non-perturbative effective couplingmore » $$\\alpha_s^{AdS}(Q^2)$$. It agrees with hadron physics data extracted from different observables, such as the effective charge defined by the Bjorken sum rule, as well as with the predictions of models with built-in confinement and lattice simulations. It also displays a transition from perturbative to nonperturbative conformal regimes at a momentum scale $$ \\sim 1$$ GeV. The resulting $$\\beta$$-function appears to capture the essential characteristics of the full $$\\beta$$-function of QCD, thus giving further support to the application of the gauge/gravity duality to the confining dynamics of strongly coupled QCD. Commensurate scale relations relate observables to each other without scheme or scale ambiguity. In this paper we extrapolate these relations to the nonperturbative domain, thus extending the range of predictions based on $$\\alpha_s^{AdS}(Q^2)$$.« less

  8. Measurement of the neutron F2 structure function via spectator tagging with CLAS

    SciTech Connect (OSTI)

    Baillie, N.; Tkachenko, S.; Zhang, J.; Bosted, P.; Bltmann, S.; Christy, M. E.; Fenker, H.; Griffioen, K. A.; Keppel, C. E.; Kuhn, S. E.; Melnitchouk, W.; Tvaskis, V.; Adhikari, K. P.; Adikaram, D.; Aghasyan, M.; Amaryan, M. J.; Anghinolfi, M.; Arrington, J.; Avakian, H.; Baghdasaryan, H.; Battaglieri, M.; Biselli, A. S.; Branford, D.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Cole, P. L.; Contalbrigo, M.; Crede, V.; DAngelo, A.; Daniel, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Deur, A.; Dey, B.; Djalali, C.; Dodge, G.; Domingo, J.; Doughty, D.; Dupre, R.; Dutta, D.; Ent, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Fradi, A.; Gabrielyan, M. Y.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Graham, L.; Guegan, B.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Heddle, D.; Hicks, K.; Holtrop, M.; Hungerford, E.; Hyde, C. E.; Ilieva, Y.; Ireland, D. G.; Ispiryan, M.; Isupov, E. L.; Jawalkar, S. S.; Jo, H. S.; Kalantarians, N.; Khandaker, M.; Khetarpal, P.; Kim, A.; Kim, W.; King, P. M.; Klein, A.; Klein, F. J.; Klimenko, A.; Kubarovsky, V.; Kuleshov, S. V.; Kvaltine, N. D.; Livingston, K.; Lu, H. Y.; MacGregor, I. J. D.; Mao, Y.; Markov, N.; McKinnon, B.; Mineeva, T.; Morrison, B.; Moutarde, H.; Munevar, E.; Nadel-Turonski, P.; Ni, A.; Niccolai, S.; Niculescu, I.; Niculescu, G.; Osipenko, M.; Ostrovidov, A. I.; Pappalardo, L.; Park, K.; Park, S.; Pasyuk, E.; Anefalos Pereira, S.; Pisano, S.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Prok, Y.; Protopopescu, D.; Raue, B. A.; Ricco, G.; Rimal, D.; Ripani, M.; Rosner, G.; Rossi, P.; Sabati, F.; Saini, M. S.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seder, E.; Sharabian, Y. G.; Sober, D. I.; Sokhan, D.; Stepanyan, S.; Stepanyan, S. S.; Stoler, P.; Strauch, S.; Taiuti, M.; Tang, W.; Ungaro, M.; Vineyard, M. F.; Voutier, E.; Watts, D. P.; Weinstein, L. B.; Weygand, D. P.; Wood, M. H.; Zana, L.; Zhao, B.

    2012-04-01

    We report on the first measurement of the F2 structure function of the neutron from semi-inclusive scattering of electrons from deuterium, with low-momentum protons detected in the backward hemisphere. Restricting the momentum of the spectator protons to ?< 100 MeV and their angles to ?> 100 degrees relative to the momentum transfer allows an interpretation of the process in terms of scattering from nearly on-shell neutrons. The F2n data collected cover the nucleon resonance and deep-inelastic regions over a wide range of x for 0.65 < Q2 < 4.52 GeV2, with uncertainties from nuclear corrections estimated to be less than a few percent. These measurements provide the first determination of the neutron to proton structure function ratio F2n/F2p at 0.2 ?< x ?< 0.8, essentially free of nuclear corrections.

  9. Remote sensing-based characterization, 2-m, Plant Functional Type Distributions, Barrow Environmental Observatory, 2010

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Zachary Langford; Forrest Hoffman; Jitendra Kumar

    2014-01-01

    Arctic ecosystems have been observed to be warming faster than the global average and are predicted to experience accelerated changes in climate due to global warming. Arctic vegetation is particularly sensitive to warming conditions and likely to exhibit shifts in species composition, phenology and productivity under changing climate. Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral characteristics which can be harnessed to discriminate plant types and develop quantitative vegetation indices. We have combined high resolution multi-spectral remote sensing from the WorldView 2 satellite with LIDAR-derived digital elevation models to characterize the tundra landscape on the North Slope of Alaska. Classification of landscape using spectral and topographic characteristics yields spatial regions with expectedly similar vegetation characteristics. A field campaign was conducted during peak growing season to collect vegetation harvests from a number of 1m x 1m plots in the study region, which were then analyzed for distribution of vegetation types in the plots. Statistical relationships were developed between spectral and topographic characteristics and vegetation type distributions at the vegetation plots. These derived relationships were employed to statistically upscale the vegetation distributions for the landscape based on spectral characteristics. Vegetation distributions developed are being used to provide Plant Functional Type (PFT) maps for use in the Community Land Model (CLM).

  10. Sexual Function After Stereotactic Body Radiotherapy for Prostate Cancer: Results of a Prospective Clinical Trial

    SciTech Connect (OSTI)

    Wiegner, Ellen A. [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA (United States); King, Christopher R., E-mail: crking@stanford.ed [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA (United States)

    2010-10-01

    Purpose: To study the sexual quality of life for prostate cancer patients after stereotactic body radiotherapy (SBRT). Methods and Materials: Using the Expanded Prostate Cancer Index Composite (EPIC)-validated quality-of-life questionnaire, the sexual function of 32 consecutive patients who received prostate SBRT in a prospective Phase II clinical trial were analyzed at baseline, and at median times of 4, 12, 20, and 50 months after treatment. SBRT consisted of 36.25 Gy in five fractions of 7.25 Gy using the Cyberknife. No androgen deprivation therapy was given. The use of erectile dysfunction (ED) medications was monitored. A comprehensive literature review for radiotherapy-alone modalities based on patient self-reported questionnaires served as historical comparison. Results: Median age at treatment was 67.5 years, and median follow-up was 35.5 months (minimum 12 months). The mean EPIC sexual domain summary score, sexual function score, and sexual bother score decreased by 45%, 49%, and 25% respectively at 50 months follow-up. These differences reached clinical relevance by 20 months after treatment. Baseline ED rate was 38% and increased to 71% after treatment (p = 0.024). Use of ED medications was 3% at baseline and progressed to 25%. For patients aged <70 years at follow-up, 60% maintained satisfactory erectile function after treatment compared with only 12% aged {>=}70 years (p = 0.008). Penile bulb dose was not associated with ED. Conclusions: The rates of ED after treatment appear comparable to those reported for other modalities of radiotherapy. Given the modest size of this study and the uncertainties in the physiology of radiotherapy-related ED, these results merit further investigations.

  11. Multiple soft limits of cosmological correlation functions

    SciTech Connect (OSTI)

    Joyce, Austin; Khoury, Justin; Simonovi?, Marko E-mail: jkhoury@sas.upenn.edu

    2015-01-01

    We derive novel identities satisfied by inflationary correlation functions in the limit where two external momenta are taken to be small. We derive these statements in two ways: using background-wave arguments and as Ward identities following from the fixed-time path integral. Interestingly, these identities allow us to constrain some of the O(q{sup 2}) components of the soft limit, in contrast to their single-soft analogues. We provide several nontrivial checks of our identities both in the context of resonant non-Gaussianities and in small sound speed models. Additionally, we extend the relation at lowest order in external momenta to arbitrarily many soft legs, and comment on the many-soft extension at higher orders in the soft momentum. Finally, we consider how higher soft limits lead to identities satisfied by correlation functions in large-scale structure.

  12. Arterial endothelial function measurement method and apparatus

    DOE Patents [OSTI]

    Maltz, Jonathan S; Budinger, Thomas F

    2014-03-04

    A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.

  13. Infrared photoemitting diode having reduced work function

    DOE Patents [OSTI]

    Hirschfeld, T.B.

    1982-05-06

    In electro-optical detectors which include as elements a photoemitting photocathode and anode, a photoemitting diode is fabricated which lowers the diode's work function, thus reducing the cooling requirement typically needed for this type of device. The work function is reduced by sandwiching between the photocathode and anode a liquid meidum of the formula NR/sub 3/ and having an electron affinity for the electrons of the photocathode, which liquid medium permits free electrons leaving the photocathode to remain as stable solvated species in the liquid medium. Thus, highly light-absorbent, and therefore thin, metallic layers can be used for detection, thereby reducing dark current at a given temperature, with a consequent reduction in cooling requirements at constant detector performance.

  14. Infrared photoemitting diode having reduced work function

    DOE Patents [OSTI]

    Hirschfeld, Tomas B.

    1984-01-01

    In electro-optical detectors which include as elements a photoemitting photocathode and anode, a photoemitting diode is fabricated which lowers the diode's work function, thus reducing the cooling requirement typically needed for this type of device. The work function is reduced by sandwiching between the photocathode and anode a liquid medium of the formula NR.sub.3 and having an electron affinity for the electrons of the photocathode, which liquid medium permits free electrons leaving the photocathode to remain as stable solvated species in the liquid medium. Thus, highly light-absorbent, and therefore thin, metallic layers can be used for detection, thereby reducing dark current at a given temperature, with a consequent reduction in cooling requirements at constant detector performance.

  15. Bidirectional reflection functions from surface bump maps

    SciTech Connect (OSTI)

    Cabral, B.; Max, N.; Springmeyer, R.

    1987-04-29

    The Torrance-Sparrow model for calculating bidirectional reflection functions contains a geometrical attenuation factor to account for shadowing and occlusions in a hypothetical distribution of grooves on a rough surface. Using an efficient table-based method for determining the shadows and occlusions, we calculate the geometric attenuation factor for surfaces defined by a specific table of bump heights. Diffuse and glossy specular reflection of the environment can be handled in a unified manner by using an integral of the bidirectional reflection function times the environmental illumination, over the hemisphere of solid angle above a surface. We present a method of estimating the integral, by expanding the bidirectional reflection coefficient in spherical harmonics, and show how the coefficients in this expansion can be determined efficiently by reorganizing our geometric attenuation calculation.

  16. Radiation Protection Functional Area Qualification Standard

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    MEASUREMENT SENSITIVE DOE-STD-1174-2013 November 2013 DOE STANDARD RADIATION PROTECTION FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. DOE-STD-1174-2013 This document is available on the Department of Energy Technical Standards Program Website at http://www.hss.energy.gov/nuclearsafety/techstds/ ii ii

  17. dual-function | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Novel Dual Functional Membrane for Controlling Carbon Dioxide Emissions from Fossil Fueled Power Plants Project No.: FG26-04NT42120 Microstructure of the composite membrane Overview of the microstructure of the composite membrane comprising of: (1) a commericially available tubular or hollow fiber ceramic support; (2) a mesoporous surfactant-templated silica sub-layer with pore size 15-50 Å; and (3) a Microporous aminosilicate gas separation membrane layer with pore size 4-10 Å. This completed

  18. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Print Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to artificial enzymes. Because peptoids are highly designable polymers, nanosheets provide a

  19. The Full Function Test Explosive Generator

    SciTech Connect (OSTI)

    Reisman, D B; Javedani, J B; Griffith, L V; Ellsworth, G F; Kuklo, R M; Goerz, D A; White, A D; Tallerico, L J; Gidding, D A; Murphy, M J; Chase, J B

    2009-12-13

    We have conducted three tests of a new pulsed power device called the Full Function Test (FFT). These tests represented the culmination of an effort to establish a high energy pulsed power capability based on high explosive pulsed power (HEPP) technology. This involved an extensive computational modeling, engineering, fabrication, and fielding effort. The experiments were highly successful and a new US record for magnetic energy was obtained.

  20. Functionalizing Nanotubes for Biomedical Applications - Donghui Zhang,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chemistry Department Functionalizing Nanotubes for Biomedical Applications Donghui Zhang, LSU Chemistry Department Carbon nanotubes (CNT) are one dimensional nano-structures with novel materials properties (e.g., high mechanical strength, thermal and electrical conductivity). Strategies that enable orientational or spatial control of CNT will facilitate their integration with existing technologies where their novel properties can be optimally utilized. In this project, Dr. Donhui Zhang, LSU

  1. Functional electrolyte for lithium-ion batteries

    DOE Patents [OSTI]

    Zhang, Lu; Zhang, Zhengcheng; Amine, Khalil

    2015-04-14

    Functional electrolyte solvents include compounds having at least one aromatic ring with 2, 3, 4 or 5 substituents, at least one of which is a substituted or unsubstituted methoxy group, at least one of which is a tert-butyl group and at least one of which is a substituted or unsubstituted polyether or poly(ethylene oxide) (PEO) group bonded through oxygen to the aromatic ring, are provided.

  2. Nuclear Safety Specialist Functional Area Qualification Standard

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    83-2007 November 2007 DOE STANDARD NUCLEAR SAFETY SPECIALIST FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. DOE-STD-1183-2007 ii This document is available on the Department of Energy Technical Standards Program Web Site at http://www.hss.energy.gov/nuclearsafety/techstds/ DOE-STD-1183-2007 iv INTENTIONALLY BLANK

  3. Occupational Safety Functional Area Qualification Standard

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    11 July 2011 DOE STANDARD OCCUPATIONAL SAFETY FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. NOT MEASUREMENT SENSITIVE DOE-STD-1160-2011 ii This document is available on the Department of Energy Technical Standards Program website at http://www.hss.energy.gov/nuclearsafety/ns/techstds/ DOE-STD-1160-2011 iv

  4. Quality Assurance Functional Area Qualification Standard

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    NOT MEASUREMENT SENSITIVE DOE-STD-1150-2013 December 2013 DOE STANDARD QUALITY ASSURANCE FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A: Approved for public release; distribution is unlimited. DOE-STD-1150-2013 This document is available on the Department of Energy Technical Standards Program Website at http://www.hss.energy.gov/nuclearsafety/ns/techstds/ ii

  5. Functional Area Criteria & Review Approach Documents

    Broader source: Energy.gov [DOE]

    CRADS provided on this page are provided as examples of functional area Objectives and Criteria used to evaluate how requirements are meet. They are only examples and should not be utilized as is. In accordance with DOE Standard 3006-2010, CRADs should be developed by team members to reflect the specifics of the proposed review (i.e., breadth and depth) as defined in the approved Plan of Action.

  6. Redshift distortions of galaxy correlation functions

    SciTech Connect (OSTI)

    Fry, J.N. Florida Univ., Gainesville, FL . Dept. of Physics); Gaztanaga, E. Oxford Univ. . Dept. of Physics)

    1993-05-12

    To examine how peculiar velocities can affect the 2-, 3-, and 4-point correlation functions, we evaluate volume-average correlations for configurations that emphasize and minimize distortions for four different volume-limited samples from each of the CfA, SSRS, and IRAS redshift catalogs. We present the results as the correlation length r[sub 0] and power index [gamma] of the 2-point correlation, [anti [Xi

  7. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Print Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to artificial enzymes. Because peptoids are highly designable polymers, nanosheets provide a

  8. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Print Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to artificial enzymes. Because peptoids are highly designable polymers, nanosheets provide a

  9. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Print Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to artificial enzymes. Because peptoids are highly designable polymers, nanosheets provide a

  10. Industrial Hygiene Functional Area Qualification Standard

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    38-2007 November 2007 DOE STANDARD INDUSTRIAL HYGIENE FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. DOE-STD-1138-2007 ii This document is available on the Department of Energy Technical Standards Program Web Site at http://www.hss.energy.gov/nuclearsafety/techstds/ DOE-STD-1138-2007 iv INTENTIONALLY BLANK

  11. Instrumentation and Control Functional Area Qualification Standard

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    NOT MEASUREMENT SENSITIVE DOE-STD-1162-2013 June 2013 DOE STANDARD INSTRUMENTATION AND CONTROL FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A: Approved for public release; distribution is unlimited. DOE-STD-1162-2013 This document is available on the Department of Energy Technical Standards Program website at http://www.hss.energy.gov/nuclearsafety/ns/techstds/ ii

  12. The structure and function of presynaptic endosomes

    SciTech Connect (OSTI)

    Jähne, Sebastian; Rizzoli, Silvio O.; Helm, Martin S.

    2015-07-15

    The function of endosomes and of endosome-like structures in the presynaptic compartment is still controversial. This is in part due to the absence of a consensus on definitions and markers for these compartments. Synaptic endosomes are sometimes seen as stable organelles, permanently present in the synapse. Alternatively, they are seen as short-lived intermediates in synaptic vesicle recycling, arising from the endocytosis of large vesicles from the plasma membrane, or from homotypic fusion of small vesicles. In addition, the potential function of the endosome is largely unknown in the synapse. Some groups have proposed that the endosome is involved in the sorting of synaptic vesicle proteins, albeit others have produced data that deny this possibility. In this review, we present the existing evidence for synaptic endosomes, we discuss their potential functions, and we highlight frequent technical pitfalls in the analysis of this elusive compartment. We also sketch a roadmap to definitely determine the role of synaptic endosomes for the synaptic vesicle cycle. Finally, we propose a common definition of synaptic endosome-like structures.

  13. Development of a functionalized Xenon biosensor

    SciTech Connect (OSTI)

    Spence, Megan M.; Ruiz, E. Janette; Rubin, Seth M.; Lowery, Thomas J.; Winssinger, Nicolas; Schultz, Peter G.; Wemmer, David E.; Pines, Alexander

    2004-03-25

    NMR-based biosensors that utilize laser-polarized xenon offer potential advantages beyond current sensing technologies. These advantages include the capacity to simultaneously detect multiple analytes, the applicability to in vivo spectroscopy and imaging, and the possibility of remote amplified detection. Here we present a detailed NMR characterization of the binding of a biotin-derivatized caged-xenon sensor to avidin. Binding of functionalized xenon to avidin leads to a change in the chemical shift of the encapsulated xenon in addition to a broadening of the resonance, both of which serve as NMR markers of ligand-target interaction. A control experiment in which the biotin-binding site of avidin was blocked with native biotin showed no such spectral changes, confirming that only specific binding, rather than nonspecific contact, between avidin and functionalized xenon leads to the effects on the xenon NMR spectrum. The exchange rate of xenon (between solution and cage) and the xenon spin-lattice relaxation rate were not changed significantly upon binding. We describe two methods for enhancing the signal from functionalized xenon by exploiting the laser-polarized xenon magnetization reservoir. We also show that the xenon chemical shifts are distinct for xenon encapsulated in different diastereomeric cage molecules. This demonstrates the potential for tuning the encapsulated xenon chemical shift, which is a key requirement for being able to multiplex the biosensor.

  14. Maximum entropy models of ecosystem functioning

    SciTech Connect (OSTI)

    Bertram, Jason

    2014-12-05

    Using organism-level traits to deduce community-level relationships is a fundamental problem in theoretical ecology. This problem parallels the physical one of using particle properties to deduce macroscopic thermodynamic laws, which was successfully achieved with the development of statistical physics. Drawing on this parallel, theoretical ecologists from Lotka onwards have attempted to construct statistical mechanistic theories of ecosystem functioning. Jaynes’ broader interpretation of statistical mechanics, which hinges on the entropy maximisation algorithm (MaxEnt), is of central importance here because the classical foundations of statistical physics do not have clear ecological analogues (e.g. phase space, dynamical invariants). However, models based on the information theoretic interpretation of MaxEnt are difficult to interpret ecologically. Here I give a broad discussion of statistical mechanical models of ecosystem functioning and the application of MaxEnt in these models. Emphasising the sample frequency interpretation of MaxEnt, I show that MaxEnt can be used to construct models of ecosystem functioning which are statistical mechanical in the traditional sense using a savanna plant ecology model as an example.

  15. Combined photonics and MEMs function demonstration

    SciTech Connect (OSTI)

    Blum, O.; Warren, M.E.; Hou, H.Q.; Choquette, K.D.; Rogers, M.S.; Sniegowski, J.J. [Sandia National Labs., Albuquerque, NM (United States); Carson, R.F. [Microoptical Devices, Inc., Albuquerque, NM (United States)

    1998-01-01

    The authors have recently demonstrated two prototypes where photonics and microelectromechanical system (MEMs) technologies have been integrated to show proof-of-principle functionality for weapon surety functions. These activities are part of a program which is exploring the miniaturization of electromechanical components for making weapon systems safer. Such miniaturization can lead to a low-cost, small, high-performance ``systems-on-a-chip``, and have many applications ranging from advanced military systems to large-volume commercial markets like automobiles, rf or land-based communications networks and equipment, or commercial electronics. One of the key challenges in realization of the microsystem is integration of several technologies including digital electronics; analog and rf electronics, optoelectronics (light emitting and detecting devices and circuits), sensors and actuators, and advanced packaging technologies. In this work the authors describe efforts in integrating MEMs and photonic functions and the fabrication constraints on both system components. Here, they discuss two examples of integration of MEMs and a photonic device. In the first instance, a MEMs locking device pin is driven by a voltage generated by photovoltaic cells connected in series, which are driven by a laser. In the second case, a VCSEL emitting at 1.06 {micro}m is packaged together with a metallized MEMs shutter. By appropriate alignment to the opening in the shutter, the VCSEL is turned on and off by the movement of the Si chopper wheel.

  16. Functional and Structural Characterization of Human V3-Specific...

    Office of Scientific and Technical Information (OSTI)

    Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 ... Title: Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody ...

  17. Structure and function of lysosomal ;#8203;phospholipase A2 and...

    Office of Scientific and Technical Information (OSTI)

    function of lysosomal ;8203;phospholipase A2 and ;8203;lecithin:cholesterol acyltransferase Citation Details In-Document Search Title: Structure and function of lysosomal...

  18. Density Functional Theory Approach to Nuclear Fission (Conference...

    Office of Scientific and Technical Information (OSTI)

    Density Functional Theory Approach to Nuclear Fission Citation Details In-Document Search Title: Density Functional Theory Approach to Nuclear Fission You are accessing a document ...

  19. Density Functional Theory Study of Surface Carbonate Formation...

    Office of Scientific and Technical Information (OSTI)

    Density Functional Theory Study of Surface Carbonate Formation on BaO(001) Citation Details In-Document Search Title: Density Functional Theory Study of Surface Carbonate Formation ...

  20. De novo design of functional proteins: Toward artificial hydrogenases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    De novo design of functional proteins: Toward artificial hydrogenases Authors: Faiella, M., Roy, A., Sommer, D., Ghirlanda, G. Title: De novo design of functional proteins: Toward ...

  1. SECURITY CORE FUNCTION AND DEFINITION REPORT | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    SECURITY CORE FUNCTION AND DEFINITION REPORT SECURITY CORE FUNCTION AND DEFINITION REPORT The first phase of the Lemnos Interoperable Security Program shall lay the foundation for ...

  2. ALS Capabilities Reveal Multiple Functions of Ebola Virus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reveal Multiple Functions of Ebola Virus Print A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its function....

  3. Error Analysis in Nuclear Density Functional Theory (Journal...

    Office of Scientific and Technical Information (OSTI)

    Error Analysis in Nuclear Density Functional Theory Citation Details In-Document Search Title: Error Analysis in Nuclear Density Functional Theory Authors: Schunck, N ; McDonnell,...

  4. Error Analysis in Nuclear Density Functional Theory (Journal...

    Office of Scientific and Technical Information (OSTI)

    Error Analysis in Nuclear Density Functional Theory Citation Details In-Document Search Title: Error Analysis in Nuclear Density Functional Theory You are accessing a document...

  5. Deep Bed Adsorption Testing using Silver-Functionalized Aerogel...

    Office of Scientific and Technical Information (OSTI)

    Deep Bed Adsorption Testing using Silver-Functionalized Aerogel Citation Details In-Document Search Title: Deep Bed Adsorption Testing using Silver-Functionalized Aerogel Nuclear ...

  6. Pairing Nambu-Goldstone Modes within Nuclear Density Functional...

    Office of Scientific and Technical Information (OSTI)

    Pairing Nambu-Goldstone Modes within Nuclear Density Functional Theory Citation Details ... Title: Pairing Nambu-Goldstone Modes within Nuclear Density Functional Theory Authors: ...

  7. Emergency Support Function #12; Energy Annex - Support Agencies...

    Energy Savers [EERE]

    Annex - Support Agencies Emergency Support Function 12; Energy Annex - Support Agencies Emergency Support Function 12 - Energy Annex - Support Agencies and their related...

  8. Structures for Three Membrane Transport Proteins Yield Functional...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Structures for Three Membrane Transport Proteins Yield Functional Insights Print Wednesday, 27 January ...

  9. Accuracy of density functionals for molecular electronics: The...

    Office of Scientific and Technical Information (OSTI)

    Accuracy of density functionals for molecular electronics: The Anderson junction Title: Accuracy of density functionals for molecular electronics: The Anderson junction Authors: ...

  10. From Protein Structure to Function: Ring Cycle for Dilating and...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    From Protein Structure to Function: Ring Cycle for Dilating and Constricting the Nuclear Pore From Protein Structure to Function: Ring Cycle for Dilating and Constricting the...

  11. Green's function multiple-scattering theory with a truncated...

    Office of Scientific and Technical Information (OSTI)

    Green's function multiple-scattering theory with a truncated basis set: An augmented-KKR formalism Prev Next Title: Green's function multiple-scattering theory with a ...

  12. Measurement of brachial artery endothelial function using a standard...

    Office of Scientific and Technical Information (OSTI)

    Measurement of brachial artery endothelial function using a standard blood pressure cuff ... artery endothelial function using a standard blood pressure cuff Authors: Maltz, ...

  13. Probability Density Function Method for Langevin Equations with...

    Office of Scientific and Technical Information (OSTI)

    Probability Density Function Method for Langevin Equations with Colored Noise Citation Details In-Document Search Title: Probability Density Function Method for Langevin Equations ...

  14. Internal compiler error for function pointer with identically...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Internal compiler error for function pointer with identically named arguments Internal compiler error for function pointer with identically named arguments June 9, 2015 by Scott...

  15. Catalyst functionalized buffer sorbent pebbles for rapid separation...

    Office of Scientific and Technical Information (OSTI)

    Catalyst functionalized buffer sorbent pebbles for rapid separation of carbon dioxide from gas mixtures Title: Catalyst functionalized buffer sorbent pebbles for rapid separation ...

  16. Research Update: Towards designed functionalities in oxide-based...

    Office of Scientific and Technical Information (OSTI)

    Research Update: Towards designed functionalities in oxide-based electronic materials Citation Details In-Document Search Title: Research Update: Towards designed functionalities...

  17. Smisc - A collection of miscellaneous functions

    SciTech Connect (OSTI)

    Landon Sego, PNNL

    2015-08-31

    A collection of functions for statistical computing and data manipulation. These include routines for rapidly aggregating heterogeneous matrices, manipulating file names, loading R objects, sourcing multiple R files, formatting datetimes, multi-core parallel computing, stream editing, specialized plotting, etc. • Smisc-package A collection of miscellaneous functions allMissing Identifies missing rows or columns in a data frame or matrix as.numericSilent Silent wrapper for coercing a vector to numeric comboList Produces all possible combinations of a set of linear model predictors cumMax Computes the maximum of the vector up to the current index cumsumNA Computes the cummulative sum of a vector without propogating NAs d2binom Probability functions for the sum of two independent binomials dataIn A flexible way to import data into R. dbb The Beta-Binomial Distribution df2list Row-wise conversion of a data frame to a list dfplapply Parallelized single row processing of a data frame dframeEquiv Examines the equivalence of two dataframes or matrices dkbinom Probability functions for the sum of k independent binomials factor2character Converts all factor variables in a dataframe to character variables findDepMat Identify linearly dependent rows or columns in a matrix formatDT Converts date or datetime strings into alternate formats getExtension Filename manipulations: remove the extension or path, extract the extension or path getPath Filename manipulations: remove the extension or path, extract the extension or path grabLast Filename manipulations: remove the extension or path, extract the extension or path ifelse1 Non-vectorized version of ifelse integ Simple numerical integration routine interactionPlot Two-way Interaction Plot with Error Bar linearMap Linear mapping of a numerical vector or scalar list2df Convert a list to a data frame loadObject Loads and returns the object(s) in an ".Rdata" file more Display the contents of a file to the R terminal movAvg2

  18. Smisc - A collection of miscellaneous functions

    Energy Science and Technology Software Center (OSTI)

    2015-08-31

    A collection of functions for statistical computing and data manipulation. These include routines for rapidly aggregating heterogeneous matrices, manipulating file names, loading R objects, sourcing multiple R files, formatting datetimes, multi-core parallel computing, stream editing, specialized plotting, etc. • Smisc-package A collection of miscellaneous functions allMissing Identifies missing rows or columns in a data frame or matrix as.numericSilent Silent wrapper for coercing a vector to numeric comboList Produces all possible combinations of a set ofmore » linear model predictors cumMax Computes the maximum of the vector up to the current index cumsumNA Computes the cummulative sum of a vector without propogating NAs d2binom Probability functions for the sum of two independent binomials dataIn A flexible way to import data into R. dbb The Beta-Binomial Distribution df2list Row-wise conversion of a data frame to a list dfplapply Parallelized single row processing of a data frame dframeEquiv Examines the equivalence of two dataframes or matrices dkbinom Probability functions for the sum of k independent binomials factor2character Converts all factor variables in a dataframe to character variables findDepMat Identify linearly dependent rows or columns in a matrix formatDT Converts date or datetime strings into alternate formats getExtension Filename manipulations: remove the extension or path, extract the extension or path getPath Filename manipulations: remove the extension or path, extract the extension or path grabLast Filename manipulations: remove the extension or path, extract the extension or path ifelse1 Non-vectorized version of ifelse integ Simple numerical integration routine interactionPlot Two-way Interaction Plot with Error Bar linearMap Linear mapping of a numerical vector or scalar list2df Convert a list to a data frame loadObject Loads and returns the object(s) in an ".Rdata" file more Display the contents of a file to the R terminal movAvg2

  19. The problem of the universal density functional and the density matrix functional theory

    SciTech Connect (OSTI)

    Bobrov, V. B. Trigger, S. A.

    2013-04-15

    The analysis in this paper shows that the Hohenberg-Kohn theorem is the constellation of two statements: (i) the mathematically rigorous Hohenberg-Kohn lemma, which demonstrates that the same ground-state density cannot correspond to two different potentials of an external field, and (ii) the hypothesis of the existence of the universal density functional. Based on the obtained explicit expression for the nonrel-ativistic particle energy in a local external field, we prove that the energy of the system of more than two non-interacting electrons cannot be a functional of the inhomogeneous density. This result is generalized to the system of interacting electrons. It means that the Hohenberg-Kohn lemma cannot provide justification of the universal density functional for fermions. At the same time, statements of the density functional theory remain valid when considering any number of noninteracting ground-state bosons due to the Bose condensation effect. In the framework of the density matrix functional theory, the hypothesis of the existence of the universal density matrix functional corresponds to the cases of noninteracting particles and to interaction in the Hartree-Fock approximation.

  20. Acidity of the amidoxime functional group in aqueous solution. A combined experimental and computational study

    SciTech Connect (OSTI)

    Mehio, Nada; Lashely, Mark A.; Nugent, Joseph W.; Tucker, Lyndsay; Correia, Bruna; Do-Thanh, Chi-Linh; Dai, Sheng; Hancock, Robert D.; Bryantsev, Vyacheslav S.

    2015-01-26

    Poly(acrylamidoxime) adsorbents are often invoked in discussions of mining uranium from seawater. It has been demonstrated repeatedly in the literature that the success of these materials is due to the amidoxime functional group. While the amidoxime-uranyl chelation mode has been established, a number of essential binding constants remain unclear. This is largely due to the wide range of conflicting pKa values that have been reported for the amidoxime functional group in the literature. To resolve this existing controversy we investigated the pKa values of the amidoxime functional group using a combination of experimental and computational methods. Experimentally, we used spectroscopic titrations to measure the pKa values of representative amidoximes, acetamidoxime and benzamidoxime. Computationally, we report on the performance of several protocols for predicting the pKa values of aqueous oxoacids. Calculations carried out at the MP2 or M06-2X levels of theory combined with solvent effects calculated using the SMD model provide the best overall performance with a mean absolute error of 0.33 pKa units and 0.35 pKa units, respectively, and a root mean square deviation of 0.46 pKa units and 0.45 pKa units, respectively. Finally, we employ our two best methods to predict the pKa values of promising, uncharacterized amidoxime ligands. Hence, our study provides a convenient means for screening suitable amidoxime monomers for future generations of poly(acrylamidoxime) adsorbents used to mine uranium from seawater.

  1. Acidity of the amidoxime functional group in aqueous solution. A combined experimental and computational study

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mehio, Nada; Lashely, Mark A.; Nugent, Joseph W.; Tucker, Lyndsay; Correia, Bruna; Do-Thanh, Chi-Linh; Dai, Sheng; Hancock, Robert D.; Bryantsev, Vyacheslav S.

    2015-01-01

    Poly(acrylamidoxime) adsorbents are often invoked in discussions of mining uranium from seawater. It has been demonstrated repeatedly in the literature that the success of these materials is due to the amidoxime functional group. While the amidoxime-uranyl chelation mode has been established, a number of essential binding constants remain unclear. This is largely due to the wide range of conflicting pKa values that have been reported for the amidoxime functional group in the literature. To resolve this existing controversy we investigated the pKa values of the amidoxime functional group using a combination of experimental and computational methods. Experimentally, we used spectroscopicmore » titrations to measure the pKa values of representative amidoximes, acetamidoxime and benzamidoxime. Computationally, we report on the performance of several protocols for predicting the pKa values of aqueous oxoacids. Calculations carried out at the MP2 or M06-2X levels of theory combined with solvent effects calculated using the SMD model provide the best overall performance with a mean absolute error of 0.33 pKa units and 0.35 pKa units, respectively, and a root mean square deviation of 0.46 pKa units and 0.45 pKa units, respectively. Finally, we employ our two best methods to predict the pKa values of promising, uncharacterized amidoxime ligands. Hence, our study provides a convenient means for screening suitable amidoxime monomers for future generations of poly(acrylamidoxime) adsorbents used to mine uranium from seawater.« less

  2. Effects of in vitro nickel exposure on the macrophage-mediated immune functions of rainbow trout (Oncorhynchus mykiss)

    SciTech Connect (OSTI)

    Bowser, D.H.; Frenkel, K.; Zelikoff, J.T. )

    1994-03-01

    Nickel is occurs naturally in the geophysical environment. It has become a common byproduct of industrialization. Nickel is released into the atmosphere and coal-burning power plants and trash incinerators, and is also discharged into waste water by industries which convert scrap or new nickel into alloys. The effluent that spreads to streams, rivers, and lakes may disrupt the integrity of the aquatic environment. Excess nickel contamination is hazardous to aquatic ecosystems due to its existence and bioaccumulation. While the adverse health effects associated with nickel exposure have been extensively examined in mammalian systems, very little is known concerning nickel's effects on aquatic organisms. Although trace amounts of nickel are necessary for maintaining the metabolic homeostasis of some vertebrate species, larger amounts of nickel have been shown to be toxic. In addition to being both genotoxic and carcinogenic, nickel modulates immunological functions in a variety of mammalian species. The toxic effects of nickel on the numbers, activity, and ultrastructure of macrophages (M[o]) have been well-studied. A number of other toxic metals such as copper, manganese, and cadmium modulate the immune responses of fish. To appraise the immunomodulating potential of nickel on fish, and to begin to establish baseline parameters of altered immune function as potential biomarkers of in vivo nickel exposure, elicited peritoneal macrophages from rainbow trout (Oncorhynchus mykiss) were treated in vitro with increasing concentrations of nickel sulfate (NiSO[sub 4]). Following exposure, M[o] activities important for maintaining host immunocompetence were evaluated and these include; mobility (random and stimulus-directed), production of reactive oxygen intermediates (ROI), acid phosphatase activity, and phagocytosis. 20 refs., 3 figs.

  3. The circular velocity function of group galaxies

    SciTech Connect (OSTI)

    Abramson, Louis E.; Williams, Rik J.; Benson, Andrew J.; Kollmeier, Juna A.; Mulchaey, John S.

    2014-09-20

    A robust prediction of ΛCDM cosmology is the halo circular velocity function (CVF), a dynamical cousin of the halo mass function. The correspondence between theoretical and observed CVFs is uncertain, however: cluster galaxies are reported to exhibit a power-law CVF consistent with N-body simulations, but that of the field is distinctly Schechter-like, flattened compared to ΛCDM expectations at circular velocities v {sub c} ≲ 200 km s{sup –1}. Groups offer a powerful probe of the role environment plays in this discrepancy as they bridge the field and clusters. Here, we construct the CVF for a large, mass- and multiplicity-complete sample of group galaxies from the Sloan Digital Sky Survey. Using independent photometric v {sub c} estimators, we find no transition from field to ΛCDM-shaped CVF above v {sub c} = 50 km s{sup –1} as a function of group halo mass. All groups with 12.4 ≲ log M {sub halo}/M {sub ☉} ≲ 15.1 (Local Group analogs to rich clusters) display similar Schechter-like CVFs marginally suppressed at low v {sub c} compared to that of the field. Conversely, some agreement with N-body results emerges for samples saturated with late-type galaxies, with isolated late-types displaying a CVF similar in shape to ΛCDM predictions. We conclude that the flattening of the low-v {sub c} slope in groups is due to their depressed late-type fractions—environment affecting the CVF only to the extent that it correlates with this quantity—and that previous cluster analyses may suffer from interloper contamination. These results serve as useful benchmarks for cosmological simulations of galaxy formation.

  4. Patterned functional carbon fibers from polyethylene

    SciTech Connect (OSTI)

    Hunt, Marcus A; Saito, Tomonori; Brown, Rebecca H; Kumbhar, Amar S; Naskar, Amit K

    2012-01-01

    Patterned, continuous carbon fibers with controlled surface geometry were produced from a novel melt-processible carbon precursor. This portends the use of a unique technique to produce such technologically innovative fibers in large volume for important applications. The novelties of this technique include ease of designing and fabricating fibers with customized surface contour, the ability to manipulate filament diameter from submicron scale to a couple of orders of magnitude larger scale, and the amenable porosity gradient across the carbon wall by diffusion controlled functionalization of precursor. The geometry of fiber cross-section was tailored by using bicomponent melt-spinning with shaped dies and controlling the melt-processing of the precursor polymer. Circular, trilobal, gear-shaped hollow fibers, and solid star-shaped carbon fibers of 0.5 - 20 um diameters, either in self-assembled bundle form, or non-bonded loose filament form, were produced by carbonizing functionalized-polyethylene fibers. Prior to carbonization, melt-spun fibers were converted to a char-forming mass by optimizing the sulfonation on polyethylene macromolecules. The fibers exhibited distinctly ordered carbon morphologies at the outside skin compared to the inner surface or fiber core. Such order in carbon microstructure can be further tuned by altering processing parameters. Partially sulfonated polyethylene-derived hollow carbon fibers exhibit 2-10 fold surface area (50-500 m2/g) compared to the solid fibers (10-25 m2/g) with pore sizes closer to the inside diameter of the filaments larger than the sizes on the outer layer. These specially functionalized carbon fibers hold promise for extraordinary performance improvements when used, for example, as composite reinforcements, catalyst support media, membranes for gas separation, CO2 sorbents, and active electrodes and current collectors for energy storage applications.

  5. A Green's function quantum average atom model

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Starrett, Charles Edward

    2015-05-21

    A quantum average atom model is reformulated using Green's functions. This allows integrals along the real energy axis to be deformed into the complex plane. The advantage being that sharp features such as resonances and bound states are broadened by a Lorentzian with a half-width chosen for numerical convenience. An implementation of this method therefore avoids numerically challenging resonance tracking and the search for weakly bound states, without changing the physical content or results of the model. A straightforward implementation results in up to a factor of 5 speed-up relative to an optimized orbital based code.

  6. Accelerating functional verification of an integrated circuit

    SciTech Connect (OSTI)

    Deindl, Michael; Ruedinger, Jeffrey Joseph; Zoellin, Christian G.

    2015-10-27

    Illustrative embodiments include a method, system, and computer program product for accelerating functional verification in simulation testing of an integrated circuit (IC). Using a processor and a memory, a serial operation is replaced with a direct register access operation, wherein the serial operation is configured to perform bit shifting operation using a register in a simulation of the IC. The serial operation is blocked from manipulating the register in the simulation of the IC. Using the register in the simulation of the IC, the direct register access operation is performed in place of the serial operation.

  7. Accelerating functional verification of an integrated circuit

    DOE Patents [OSTI]

    Deindl, Michael; Ruedinger, Jeffrey Joseph; Zoellin, Christian G

    2015-11-05

    Illustrative embodiments include a method, system, and computer program product for accelerating functional verification in simulation testing of an integrated circuit (IC). Using a processor and a memory, a serial operation is replaced with a direct register access operation, wherein the serial operation is configured to perform bit shifting operation using a register in a simulation of the IC. The serial operation is blocked from manipulating the register in the simulation of the IC. Using the register in the simulation of the IC, the direct register access operation is performed in place of the serial operation.

  8. High Speed SPM of Functional Materials

    SciTech Connect (OSTI)

    Huey, Bryan D.

    2015-08-14

    The development and optimization of applications comprising functional materials necessitates a thorough understanding of their static and dynamic properties and performance at the nanoscale. Leveraging High Speed SPM and concepts enabled by it, efficient measurements and maps with nanoscale and nanosecond temporal resolution are uniquely feasible. This includes recent enhancements for topographic, conductivity, ferroelectric, and piezoelectric properties as originally proposed, as well as newly developed methods or improvements to AFM-based mechanical, friction, thermal, and photoconductivity measurements. The results of this work reveal fundamental mechanisms of operation, and suggest new approaches for improving the ultimate speed and/or efficiency, of data storage systems, magnetic-electric sensors, and solar cells.

  9. Gen IV Materials Handbook Functionalities and Operation

    SciTech Connect (OSTI)

    Ren, Weiju

    2009-12-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  10. Criticality Safety Functional Area Qualification Standard

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    DOE-STD-1173-2009 April 2009 DOE STANDARD CRITICALITY SAFETY FUNCTIONAL AREA QUALIFICATION STANDARD DOE Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. DOE-STD-1173-2009 ii This document is available on the Department of Energy Technical Standards Program Web Page at http://www.hss.energy.gov/nuclearsafety/techstds/ DOE-STD-1173-2009 iii APPROVAL The Federal

  11. Functional design criteria for standard hydrogen monitoring system portable platform

    SciTech Connect (OSTI)

    Schneider, T.C.

    1997-01-17

    Functional design description for a Standard-E cabinet arrangement Standard Hydrogen Monitoring System Portable Platform.

  12. US Nuclear Regulatory Commission functional organization charts, March 15, 1993

    SciTech Connect (OSTI)

    Not Available

    1993-03-01

    Functional organization charts for the US Nuclear Regulatory Commission offices, divisions, and branches are presented.

  13. U. S. Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1989-07-01

    Functional organization charts for the US Nuclear Regulatory Commission offices, divisions and branches are presented.

  14. U. S. Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1982-02-01

    Functional organization charts for the NRC Commission Offices, Divisions, Staffs and Branches are presented.

  15. An Integrated Tool for Functional Requirements Analysis, Function Allocation and Task Analysis

    SciTech Connect (OSTI)

    Hugo, Jacques

    2015-03-02

    The software application is called “HFE-Trace”. This is an integrated method and tool for the management of Human Factors Engineering analyses and related data. Its primary purpose is to support the coherent and consistent application of the nuclear industry’s best practices for human factors engineering work. The software is a custom Microsoft® Access® application. The application is used (in conjunction with other tools such as spreadsheets, checklists and normal documents where necessary) to collect data on the design of a new nuclear power plant from subject matter experts and other sources. This information is then used to identify potential system and functional breakdowns of the intended power plant design. This information is expanded by developing extensive descriptions of all functions, as well as system performance parameters, operating limits and constraints, and operational conditions. Once these have been verified, the human factors elements are added to each function, including intended operator role, function allocation considerations, prohibited actions, primary task categories, and primary work station. In addition, the application includes a computational method to assess a number of factors such as system and process complexity, workload, environmental conditions, procedures, regulations, etc.) that may shape operator performance. This is a unique methodology based upon principles described in NUREG/CR-3331 (“A methodology for allocating nuclear power plant control functions to human or automatic control”) and it results in a semi-quantified allocation of functions to three or more levels of automation for a conceptual automation system. The aggregate of all this information is then linked to the Task Analysis section of the application where the existing information on all operator functions is transformed into task information and ultimately into design requirements for Human-System Interfaces and Control Rooms. This final step includes

  16. An Integrated Tool for Functional Requirements Analysis, Function Allocation and Task Analysis

    Energy Science and Technology Software Center (OSTI)

    2015-03-02

    The software application is called “HFE-Trace”. This is an integrated method and tool for the management of Human Factors Engineering analyses and related data. Its primary purpose is to support the coherent and consistent application of the nuclear industry’s best practices for human factors engineering work. The software is a custom Microsoft® Access® application. The application is used (in conjunction with other tools such as spreadsheets, checklists and normal documents where necessary) to collect datamore » on the design of a new nuclear power plant from subject matter experts and other sources. This information is then used to identify potential system and functional breakdowns of the intended power plant design. This information is expanded by developing extensive descriptions of all functions, as well as system performance parameters, operating limits and constraints, and operational conditions. Once these have been verified, the human factors elements are added to each function, including intended operator role, function allocation considerations, prohibited actions, primary task categories, and primary work station. In addition, the application includes a computational method to assess a number of factors such as system and process complexity, workload, environmental conditions, procedures, regulations, etc.) that may shape operator performance. This is a unique methodology based upon principles described in NUREG/CR-3331 (“A methodology for allocating nuclear power plant control functions to human or automatic control”) and it results in a semi-quantified allocation of functions to three or more levels of automation for a conceptual automation system. The aggregate of all this information is then linked to the Task Analysis section of the application where the existing information on all operator functions is transformed into task information and ultimately into design requirements for Human-System Interfaces and Control Rooms. This final step

  17. Editorial: Functional nanomaterials for energy applications

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Devan, Rupesh S.; Ma, Yuan -Ron; Kim, Jin -Hyeok; Bhattacharya, Raghu N.; Ghosh, Kartik C.

    2015-02-16

    In order to leap forward from the energy crisis issues and improve lifestyle, we all are looking positively toward nanomaterials or nanostructures. Thus, the exploration of new features of both typical and novel materials at the nanoscale level is playing important role in the development of innovative and improved energy technologies that have the capability of conserve/convert energy at large extend. By tailoring the surface morphology of materials in its nanoforms, the functional properties can be significantly adapted and specifically combined to produce highly potent multifunctional materials for conversion, storage, and consumption of energy in various forms. The papers selectedmore » for this special issue represent a good panel for addressing various energy applications including solar cell, fuel cells, nanofluid twisters, and gas sensors. Of course, the selected topic and the papers are not an exhaustive representation of the utilization of functional nanomaterials for energy applications. Nevertheless, they represent the rich and many-facet knowledge, which we have the pleasure of sharing with the readers.« less

  18. Functional relationship-based alarm processing system

    DOE Patents [OSTI]

    Corsberg, D.R.

    1988-04-22

    A functional relationship-based alarm processing system and method analyzes each alarm as it is activated and determines its relative importance with other currently activated alarms and signals in accordance with the functional relationships that the newly activated alarm has with other currently activated alarms. Once the initial level of importance of the alarm has been determined, that alarm is again evaluated if another related alarm is activated or deactivated. Thus, each alarm's importance is continuously updated as the state of the process changes during a scenario. Four hierarchical relationships are defined by this alarm filtering methodology: (1) level precursor (usually occurs when there are two alarm settings on the same parameter); (2) direct precursor (based on causal factors between two alarms); (3) required action (system response or action expected within a specified time following activation of an alarm or combination of alarms and process signals); and (4) blocking condition (alarms that are normally expected and are not considered important). The alarm processing system and method is sensitive to the dynamic nature of the process being monitored and is capable of changing the relative importance of each alarm as necessary. 12 figs.

  19. Editorial: Functional nanomaterials for energy applications

    SciTech Connect (OSTI)

    Devan, Rupesh S.; Ma, Yuan -Ron; Kim, Jin -Hyeok; Bhattacharya, Raghu N.; Ghosh, Kartik C.

    2015-02-16

    In order to leap forward from the energy crisis issues and improve lifestyle, we all are looking positively toward nanomaterials or nanostructures. Thus, the exploration of new features of both typical and novel materials at the nanoscale level is playing important role in the development of innovative and improved energy technologies that have the capability of conserve/convert energy at large extend. By tailoring the surface morphology of materials in its nanoforms, the functional properties can be significantly adapted and specifically combined to produce highly potent multifunctional materials for conversion, storage, and consumption of energy in various forms. The papers selected for this special issue represent a good panel for addressing various energy applications including solar cell, fuel cells, nanofluid twisters, and gas sensors. Of course, the selected topic and the papers are not an exhaustive representation of the utilization of functional nanomaterials for energy applications. Nevertheless, they represent the rich and many-facet knowledge, which we have the pleasure of sharing with the readers.

  20. Building a Universal Nuclear Energy Density Functional

    SciTech Connect (OSTI)

    Carlson, Joe A.; Furnstahl, Dick; Horoi, Mihai; Lust, Rusty; Nazaewicc, Witek; Ng, Esmond; Thompson, Ian; Vary, James

    2012-12-30

    During the period of Dec. 1 2006 – Jun. 30, 2012, the UNEDF collaboration carried out a comprehensive study of all nuclei, based on the most accurate knowledge of the strong nuclear interaction, the most reliable theoretical approaches, the most advanced algorithms, and extensive computational resources, with a view towards scaling to the petaflop platforms and beyond. The long-term vision initiated with UNEDF is to arrive at a comprehensive, quantitative, and unified description of nuclei and their reactions, grounded in the fundamental interactions between the constituent nucleons. We seek to replace current phenomenological models of nuclear structure and reactions with a well-founded microscopic theory that delivers maximum predictive power with well-quantified uncertainties. Specifically, the mission of this project has been three-fold:  First, to find an optimal energy density functional (EDF) using all our knowledge of the nucleonic Hamiltonian and basic nuclear properties;  Second, to apply the EDF theory and its extensions to validate the functional using all the available relevant nuclear structure and reaction data;  Third, to apply the validated theory to properties of interest that cannot be measured, in particular the properties needed for reaction theory.

  1. Joining of Tungsten Armor Using Functional Gradients

    SciTech Connect (OSTI)

    John Scott O'Dell

    2006-12-31

    The joining of low thermal expansion armor materials such as tungsten to high thermal expansion heat sink materials has been a major problem in plasma facing component (PFC) development. Conventional planar bonding techniques have been unable to withstand the high thermal induced stresses resulting from fabrication and high heat flux testing. During this investigation, innovative functional gradient joints produced using vacuum plasma spray forming techniques have been developed for joining tungsten armor to copper alloy heat sinks. A model was developed to select the optimum gradient architecture. Based on the modeling effort, a 2mm copper rich gradient was selected. Vacuum plasma pray parameters and procedures were then developed to produce the functional gradient joint. Using these techniques, dual cooling channel, medium scale mockups (32mm wide x 400mm length) were produced with vacuum plasma spray formed tungsten armor. The thickness of the tungsten armor was up to 5mm thick. No evidence of debonding at the interface between the heat sink and the vacuum plasma sprayed material was observed.

  2. Periodic subsystem density-functional theory

    SciTech Connect (OSTI)

    Genova, Alessandro; Pavanello, Michele; Ceresoli, Davide

    2014-11-07

    By partitioning the electron density into subsystem contributions, the Frozen Density Embedding (FDE) formulation of subsystem Density Functional Theory (DFT) has recently emerged as a powerful tool for reducing the computational scaling of Kohn–Sham DFT. To date, however, FDE has been employed to molecular systems only. Periodic systems, such as metals, semiconductors, and other crystalline solids have been outside the applicability of FDE, mostly because of the lack of a periodic FDE implementation. To fill this gap, in this work we aim at extending FDE to treat subsystems of molecular and periodic character. This goal is achieved by a dual approach. On one side, the development of a theoretical framework for periodic subsystem DFT. On the other, the realization of the method into a parallel computer code. We find that periodic FDE is capable of reproducing total electron densities and (to a lesser extent) also interaction energies of molecular systems weakly interacting with metallic surfaces. In the pilot calculations considered, we find that FDE fails in those cases where there is appreciable density overlap between the subsystems. Conversely, we find FDE to be in semiquantitative agreement with Kohn–Sham DFT when the inter-subsystem density overlap is low. We also conclude that to make FDE a suitable method for describing molecular adsorption at surfaces, kinetic energy density functionals that go beyond the GGA level must be employed.

  3. Surface modification of polyethylene by functionalized plasma

    SciTech Connect (OSTI)

    Yuan, S.; Marchant, R.E.

    1993-12-31

    The surface of low density polyethylene(PE) has been modified by functionalized plasma-polymerized N-vinyl-2-pyrrolidone (PPNVP) and allyl alcohol(PPAA) thin films, PPNVP and PPAA(approx. 100 nm). The surface structure and functional groups of modified surfaces were characterized by water contact angle, ATR/FTIR and ESCA techniques. Plasma polymer modified PE surfaces exhibited significant water contact angle hysteresis and a much lower value of advancing water contact angle than that of unmodified polyethylene. Reduction of PPNVP and PPAA modified surfaces by sodium borohydride coverted into hydroxyl groups. The determined concentrations of hydroxyl groups on the reduced PPNVP and PPAA modified surfaces by ESCA after gas-phase derivatization with trifluoroacetic anhydride (TFAA) were about 25% and 30% of total oxygen content, respectively. Finally, the amine containing molecules such as amine-terminated polyethylene oxide (PEO) and 3-aminopropyltriethoxysilane (APTS) were coupled to the hydroxylated surfaces. These novel modified PE surfaces are suitable for immobilization of biomolecules.

  4. Functionalized inorganic membranes for gas separation

    DOE Patents [OSTI]

    Ku, Anthony Yu-Chung; Ruud, James Anthony; Molaison, Jennifer Lynn; Schick, Louis Andrew ,; Ramaswamy, Vidya

    2008-07-08

    A porous membrane for separation of carbon dioxide from a fluid stream at a temperature higher than about 200.degree. C. with selectivity higher than Knudsen diffusion selectivity. The porous membrane comprises a porous support layer comprising alumina, silica, zirconia or stabilized zirconia; a porous separation layer comprising alumina, silica, zirconia or stabilized zirconia, and a functional layer comprising a ceramic oxide contactable with the fluid stream to preferentially transport carbon dioxide. In particular, the functional layer may be MgO, CaO, SrO, BaO, La.sub.2O.sub.3, CeO.sub.2, ATiO.sub.3, AZrO.sub.3, AAl.sub.2O.sub.4, A.sup.1FeO.sub.3, A.sup.1MnO.sub.3, A.sup.1CoO.sub.3, A.sup.1NiO.sub.3, A.sup.2HfO.sub.3, A.sup.3CeO.sub.3, Li.sub.2ZrO.sub.3, Li.sub.2SiO.sub.3, Li.sub.2TiO.sub.3 or a mixture thereof; wherein A is Mg, Ca, Sr or Ba; A.sup.1 is La, Ca, Sr or Ba; A.sup.2 is Ca, Sr or Ba; and A.sup.3 is Sr or Ba.

  5. An Orientation Distribution Function for Trabecular Bone

    SciTech Connect (OSTI)

    Lawrence Livermore National Laboratory

    2004-10-08

    We describe a new method for quantifying the orientation of trabecular bone from three-dimensional images. Trabecular lattices from five human vertebrae were decomposed into individual trabecular elements, and the orientation, mass, and thickness of each element were recorded. Continuous functions that described the total mass (M({var_phi},{theta})) and mean thickness ({tau}({var_phi},{theta})) of all trabeculae as a function of orientation were derived. The results were compared with experimental measurements of the elastic modulus in the three principal anatomic directions. A power law scaling relationship between the anisotropies in mass and elastic modulus was observed; the scaling exponent was 1.41 (R{sup 2} = 0.88). As expected, the preponderance of trabecular mass was oriented along the cranial-caudal direction; on average, there was 3.4 times more mass oriented vertically than horizontally. Moreover, the vertical trabeculae were 30% thicker, on average, than the horizontal trabeculae. The vertical trabecular thickness was inversely related to the connectivity (R{sup 2} = 0.70; p = 0.07), suggesting a possible organization into either few, thick trabeculae or many thin trabeculae. The method, which accounts for the mechanical connectedness of the lattice, provides a rapid way to both visualize and quantify the three-dimensional organization of trabecular bone.

  6. Functional relationship-based alarm processing system

    DOE Patents [OSTI]

    Corsberg, Daniel R.

    1989-01-01

    A functional relationship-based alarm processing system and method analyzes each alarm as it is activated and determines its relative importance with other currently activated alarms and signals in accordance with the functional relationships that the newly activated alarm has with other currently activated alarms. Once the initial level of importance of the alarm has been determined, that alarm is again evaluated if another related alarm is activated or deactivated. Thus, each alarm's importance is continuously updated as the state of the process changes during a scenario. Four hierarchical relationships are defined by this alarm filtering methodology: (1) level precursor (usually occurs when there are two alarm settings on the same parameter); (2) direct precursor (based on causal factors between two alarms); (3) required action (system response or action expected within a specified time following activation of an alarm or combination of alarms and process signals); and (4) blocking condition (alarms that are normally expected and are not considered important). The alarm processing system and method is sensitive to the dynamic nature of the process being monitored and is capable of changing the relative importance of each alarm as necessary.

  7. The Gut Microbiota: Ecology and Function

    SciTech Connect (OSTI)

    Willing, B.P.; Jansson, J.K.

    2010-06-01

    The gastrointestinal (GI) tract is teeming with an extremely abundant and diverse microbial community. The members of this community have coevolved along with their hosts over millennia. Until recently, the gut ecosystem was viewed as black box with little knowledge of who or what was there or their specific functions. Over the past decade, however, this ecosystem has become one of fastest growing research areas of focus in microbial ecology and human and animal physiology. This increased interest is largely in response to studies tying microbes in the gut to important diseases afflicting modern society, including obesity, allergies, inflammatory bowel diseases, and diabetes. Although the importance of a resident community of microorganisms in health was first hypothesized by Pasteur over a century ago (Sears, 2005), the multiplicity of physiological changes induced by commensal bacteria has only recently been recognized (Hooper et al., 2001). The term 'ecological development' was recently coined to support the idea that development of the GI tract is a product of the genetics of the host and the host's interactions with resident microbes (Hooper, 2004). The search for new therapeutic targets and disease biomarkers has escalated the need to understand the identities and functions of the microorganisms inhabiting the gut. Recent studies have revealed new insights into the membership of the gut microbial community, interactions within that community, as well as mechanisms of interaction with the host. This chapter focuses on the microbial ecology of the gut, with an emphasis on information gleaned from recent molecular studies.

  8. Arithmetic functions in torus and tree networks

    DOE Patents [OSTI]

    Bhanot, Gyan; Blumrich, Matthias A.; Chen, Dong; Gara, Alan G.; Giampapa, Mark E.; Heidelberger, Philip; Steinmacher-Burow, Burkhard D.; Vranas, Pavlos M.

    2007-12-25

    Methods and systems for performing arithmetic functions. In accordance with a first aspect of the invention, methods and apparatus are provided, working in conjunction of software algorithms and hardware implementation of class network routing, to achieve a very significant reduction in the time required for global arithmetic operation on the torus. Therefore, it leads to greater scalability of applications running on large parallel machines. The invention involves three steps in improving the efficiency and accuracy of global operations: (1) Ensuring, when necessary, that all the nodes do the global operation on the data in the same order and so obtain a unique answer, independent of roundoff error; (2) Using the topology of the torus to minimize the number of hops and the bidirectional capabilities of the network to reduce the number of time steps in the data transfer operation to an absolute minimum; and (3) Using class function routing to reduce latency in the data transfer. With the method of this invention, every single element is injected into the network only once and it will be stored and forwarded without any further software overhead. In accordance with a second aspect of the invention, methods and systems are provided to efficiently implement global arithmetic operations on a network that supports the global combining operations. The latency of doing such global operations are greatly reduced by using these methods.

  9. Guidance on Inherently Governmental Functions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Inherently Governmental Functions Guidance on Inherently Governmental Functions Federal law prohibits contractors from performing "inherently governmental functions." This guidance is designed to provide the basic rules applicable to the Department. Specifically, it: (1) identifies general principles for determining whether a function is inherently governmental; (2) lists functions that have been specifically identified as inherently governmental by one or more sources of Federal law,

  10. ALS Capabilities Reveal Multiple Functions of Ebola Virus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Capabilities Reveal Multiple Functions of Ebola Virus ALS Capabilities Reveal Multiple Functions of Ebola Virus Print Friday, 13 June 2014 10:25 A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its function. Scientists typically expect that a protein has a singular structure (with some conformational variation), and that when an experimental structure is solved, it can used to understand the known biological function(s) of the

  11. Design of the IPIRG-2 simulated seismic forcing function

    SciTech Connect (OSTI)

    Olson, R.; Scott, P.; Wilkowski, G.

    1996-02-01

    A series of pipe system experiments was conducted in IPIRG-2 that used a realistic seismic forcing function. Because the seismic forcing function was more complex than the single-frequency increasing-amplitude sinusoidal forcing function used in the IPIRG-1 pipe system experiments, considerable effort went into designing the function. This report documents the design process for the seismic forcing function used in the IPIRG-2 pipe system experiments.

  12. Full-wave Simulations of ICRF Heating in Toroidal Plasma with Non-Maxwellian Distribution Functions in the FLR Limit

    SciTech Connect (OSTI)

    E.J. Valeo, C.K. Phillips, H. Okuda, J.C. Wright, P.T. Bonoli, L.A. Berry, and the RF SciDAC Team

    2007-07-18

    At the power levels required for signicant heating and current drive in magnetically-con ned toroidal plasma, modi cation of the particle distribution function from a Maxwellian shape is likely [T.H. Stix, Nucl. Fusion, 15:737 1975], with consequent changes in wave propagation and in the location and amount of absorption. In order to study these e ects computationally, the nite-Larmor-radius, full-wave, hot-plasma toroidal simulation code, TORIC [M. Brambilla. Plasma Phys. Controlled Fusion, 41:1, 1999], has been extended to allow the prescription of arbitrary velocity distributions of the form (?||, ??, ?, ?). For H minority heating of a D-H plasma with anisotropic Maxwellian H distributions, the fractional H absorption varies signi cantly with changes in parallel temperature but is essentially independent of perpendicular temperature.

  13. One-parameter semigroups of analytic functions, fixed points and the Koenigs function

    SciTech Connect (OSTI)

    Goryainov, Victor V; Kudryavtseva, Olga S

    2011-07-31

    Analogues of the Berkson-Porta formula for the infinitesimal generator of a one-parameter semigroup of holomorphic maps of the unit disc into itself are obtained in the case when, along with a Denjoy-Wolff point, there also exist other fixed points. With each one-parameter semigroup a so-called Koenigs function is associated, which is a solution, common for all elements of the one-parameter semigroup, of a certain functional equation (Schroeder's equation in the case of an interior Denjoy-Wolff point and Abel's equation in the case of a boundary Denjoy-Wolff point). A parametric representation for classes of Koenigs functions that takes account of the Denjoy-Wolff point and other fixed points of the maps in the one-parameter semigroup is presented. Bibliography: 19 titles.

  14. Confidential balls minimizing in mean convex functional

    SciTech Connect (OSTI)

    Kaminsky, V.

    1994-12-31

    Let H be a Hilbert space, H{sub 0} {contained_in} H be a subspace in it; {Sigma}i{sigma}-algebra of Borel subsets from H{sub 0}, s = s(x, r) is the bal of radius r with the center at the point x {element_of} H and t = t(x, r) is its boundary, a sphere. Let measure {mu} defined on {Sigma} be finite nonnegative and satisfy the following condition: {mu}(H{sub 0}) = 1. By fixing two nonnegative numbers {mu}{sub 0}, where 0 < {mu}{sub 0} < 1, and R > 0, we indicate from {sigma}-algebra {Sigma} the class S = {l_brace}s,(x, r) {element_of} {Sigma}: {mu}(s) {>=} {mu}{sub o}, r {<=} R{r_brace}. Let {var_phi}(x) be a convex eigen functional on H such that it is bounded on each ball s {element_of} S{sub 0}. It is possible to introduce an averaging functional for each ball s {element_of} S {Phi}(s) = {sub {mu}(s)}{sup 1} {integral}{sub s(x, r)} {var_phi}(y){mu}(dy) = {sub {mu}(s(x, r))}{sup 1} {integral}{sub s({theta}, r)} {var_phi}(x + {xi}){mu}(d{xi}) = F(x, r) and to consider the following extremal problem {Phi}(s) {yields} inf{sub s{epsilon}S}. We can interpret such a formulation of the problem as an extremal problem with confidential condition ({mu}s) {>=} {mu}{sub 0}. It is possible to consider the formulations of problem of such type in order to generalize the classical problems in mathematical programming in which now we find an extremal subset of an extremal element. The following results are obtained: theorems about existence of an extremal ball, necessary condition for a ball to be extremal in problems of such types, sufficient conditions of extremality of the ball by stronger restrictions on functional and measure in the problem.

  15. Functional Stability Of A Mixed Microbial Consortia Producing PHA From Waste Carbon Sources

    SciTech Connect (OSTI)

    David N. Thompson; Erik R. Coats; William A. Smith; Frank J. Loge; Michael P. Wolcott

    2006-04-01

    Polyhydroxyalkanoates (PHAs), naturally-occurring biological polyesters that are microbially synthesized from a myriad of carbon sources, can be utilized as biodegradable substitutes for petroleum-derived thermoplastics. However, current PHA commercialization schemes are limited by high feedstock costs, the requirement for aseptic reactors, and high separation and purification costs. Bacteria indigenous to municipal waste streams can accumulate large quantities of PHA under environmentally controlled conditions; hence, a potentially more environmentally-effective method of production would utilize these consortia to produce PHAs from inexpensive waste carbon sources. In this study, PHA production was accomplished in sequencing batch bioreactors utilizing mixed microbial consortia from municipal activated sludge as inoculum, in cultures grown on real wastewaters. PHA production averaged 85%, 53%, and 10% of the cell dry weight from methanol-enriched pulp-and-paper mill foul condensate, fermented municipal primary solids, and biodiesel wastewater, respectively. The PHA-producing microbial consortia were examined to explore the microbial community changes that occurred during reactor operations, employing denaturing gradient gel electrophoresis (DGGE) of 16S-rDNA from PCR-amplified DNA extracts. Distinctly different communities were observed both between and within wastewaters following enrichment. More importantly, stable functions were maintained despite the differing and contrasting microbial populations.

  16. Visualization and functional dissection of coaxial paired SpoIIIE channels across the sporulation septum

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Shin, Jae Yen; Lopez-Garrido, Javier; Lee, Sang-Hyuk; Diaz-Celis, Cesar; Fleming, Tinya; Bustamante, Carlos; Pogliano, Kit

    2015-05-07

    SpoIIIE is a membrane-anchored DNA translocase that localizes to the septal midpoint to mediate chromosome translocation and membrane fission during Bacillus subtilis sporulation. Here we use cell-specific protein degradation and quantitative photoactivated localization microscopy in strains with a thick sporulation septum to investigate the architecture and function of the SpoIIIE DNA translocation complex in vivo. We were able to visualize SpoIIIE complexes with approximately equal numbers of molecules in the mother cell and the forespore. Cell-specific protein degradation showed that only the mother cell complex is required to translocate DNA into the forespore, whereas degradation in either cell reversesmore » membrane fission. Our data suggest that SpoIIIE assembles a coaxially paired channel for each chromosome arm comprised of one hexamer in each cell to maintain membrane fission during DNA translocation. We show that SpoIIIE can operate, in principle, as a bi-directional motor that exports DNA.« less

  17. Implementation of the Locally Renormalized CCSD (T) Approaches for Abitrary Reference Function

    SciTech Connect (OSTI)

    Kowalski, Karol

    2005-07-01

    Several new variants of the locally-renormalized coupled-cluster (CC) approaches that account for the effect of triples (LR-CCSD(T)) have been formulated an implemented for arbitrary reference states using the TENSOR CONTRACTION ENGINE functionality, enabling an efficient parallel execution of the program. Deeply rooted in the recently derived Numerator-Denominator Connected (NDC) expansion for the ground-state energy [K. Kowalski, P. Piecuch, J. Chem. Phys. 122, 07107 (2005)], LR-CCSD(T) approximations use, in analogy to the completely-renormalized CCSD(T) (CR-CCSD(T)) approach, the three-body moments in constructing the non-iterative corrections to the energies obtained in CC calculations with singles and doubles. In contrast to the CR-CCSD(T) method, the LR-CCSD(T) approach employs local denominators which assure the additive separability of the energies in the non-interacting system limit when the localized basis set is employed in the CCSD and LR-CCSD(T) calculations. As clearly demonstrated on several challenging examples, including breaking the bonds of the F?, N?, and CN molecules, the LR-CCSD(T) approaches are capable of providing a highly accurate description of the entire potential energy surface (PES) while maintaining the characteristic N? scaling of the ubiquitous CCSD(T) approach. Moreover, as illustrated numerically for the ozone molecule, the LR-CCSD(T) approaches yield highly competitive values for a number of equilibrium properties including bond lengths, angles and harmonic frequencies.

  18. HANFORD SITE WELDING PROGRAM SUCCESSFULLY PROVIDING A SINGLE SITE FUNCTION FOR USE BY MULTIPLE CONTRACTORS

    SciTech Connect (OSTI)

    CANNELL GR

    2009-11-19

    The Department of Energy, Richland Operations (DOE-RL) recently restructured its Hanford work scope, awarding two new contracts over the past several months for a total of three contracts to manage the sites cleanup efforts. DOE-RL met with key contractor personnel prior to and during contract transition to ensure site welding activities had appropriate oversight and maintained code compliance. The transition also provided an opportunity to establish a single site-wide function that would provide welding and materials engineering services to the Hanford site contractors: CH2M HILL Plateau Remediation Company (CHPRC); Mission Support Alliance (MSA); Washington River Protection Solutions (WRPS); and Washington Closure Hanford (WCH). Over the years, multiple and separate welding programs (amongst the several contractors) existed at the Hanford site leading to inefficiencies resulting from duplication of administrative efforts, maintenance of welding procedures, welder performance certifications, etc. The new, single program eliminates these inefficiencies. The new program, co-managed by two of the sites' new contractors, the CHPRC ('owner' of the program and responsible for construction welding services) and the MSA (provides maintenance welding services), provides more than just the traditional construction and maintenance welding services. Also provided, are welding engineering, specialty welding development/qualification for the closure of radioactive materials containers and materials evaluation/failure analysis. The following describes the new Hanford site welding program.

  19. 340 Facility Secondary Containment and Leak Detection Project W-302 Functional Design Criteria

    SciTech Connect (OSTI)

    Stordeur, R.T.

    1995-03-01

    This functional design criteria for the upgrade to the 340 radioactive liquid waste storage facility (Project W-302) specifically addresses the secondary containment issues at the current vault facility of the 340 Complex. This vault serves as the terminus for the Radioactive Liquid Waste System (RLWS). Project W-302 is necessary in order to bring this portion of the Complex into full regulatory compliance. The project title, ``340 Facility Secondary Containment and Leak Detection``, illustrates preliminary thoughts of taking corrective action directly upon the existing vault (such as removing the tanks, lining the vault, and replacing tanks). However, based on the conclusion of the engineering study, ``Engineering Study of the 300 Area Process Wastewater Handling System``, WHC-SD-WM-ER-277 (as well as numerous follow-up meetings with cognizant staff), this FDC prescribes a complete replacement of the current tank/vault system. This offers a greater array of tanks, and provides greater operating flexibility and ease of maintenance. This approach also minimizes disruption to RLWS services during ``tie-in``, as compared to the alternative of trying to renovate the old vault. The proposed site is within the current Complex area, and maintains the receipt of RLWS solutions through gravity flow.

  20. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

    SciTech Connect (OSTI)

    Alcaraz, Jordi; Xu, Ren; Mori, Hidetoshi; Nelson, Celeste M.; Mroue, Rana; Spencer, Virginia A.; Brownfield, Doug; Radisky, Derek C.; Bustamante, Carlos; Bissell, Mina J.

    2008-10-20

    In the mammary gland, epithelial cells are embedded in a 'soft' environment and become functionally differentiated in culture when exposed to a laminin-rich extracellular matrix gel. Here, we define the processes by which mammary epithelial cells integrate biochemical and mechanical extracellular cues to maintain their differentiated phenotype. We used single cells cultured on top of gels in conditions permissive for {beta}-casein expression using atomic force microscopy to measure the elasticity of the cells and their underlying substrata. We found that maintenance of {beta}-casein expression required both laminin signalling and a 'soft' extracellular matrix, as is the case in normal tissues in vivo, and biomimetic intracellular elasticity, as is the case in primary mammary epithelial organoids. Conversely, two hallmarks of breast cancer development, stiffening of the extracellular matrix and loss of laminin signalling, led to the loss of {beta}-casein expression and non-biomimetic intracellular elasticity. Our data indicate that tissue-specific gene expression is controlled by both the tissues unique biochemical milieu and mechanical properties, processes involved in maintenance of tissue integrity and protection against tumorigenesis.