National Library of Energy BETA

Sample records for maintaining essential functions

  1. Essential Systems Functionality Inspection Criteria, Approach, and Lines of Inquiry, October 16, 2008 (HSS CRAD 64-11 Rev. 2)

    Broader source: Energy.gov [DOE]

    The Essential Systems Functionality (ESF) inspection will evaluate the effectiveness of programs and processes for engineering design and safety basis, construction and installation, configuration management, surveillance testing, maintenance, operations, cognizant system engineer (CSE) and safety system oversight (SSO), and feedback and improvement of selected safety systems. This review will evaluate the effectiveness in maintaining the functionality of these safety systems. The ESF review will be performed in the context of integrated safety management (ISM), although the inspection criteria, activities and lines of inquiry are organized by ESF functional areas rather than ISM principles and core functions.

  2. 8-Oxoguanine DNA glycosylase 1 (ogg1) maintains the function of cardiac progenitor cells during heart formation in zebrafish

    SciTech Connect (OSTI)

    Yan, Lifeng; Zhou, Yong; Yu, Shanhe; Ji, Guixiang; Liu, Wei; Gu, Aihua

    2013-11-15

    Genomic damage may devastate the potential of progenitor cells and consequently impair early organogenesis. We found that ogg1, a key enzyme initiating the base-excision repair, was enriched in the embryonic heart in zebrafish. So far, little is known about DNA repair in cardiogenesis. Here, we addressed the critical role of ogg1 in cardiogenesis for the first time. ogg1 mainly expressed in the anterior lateral plate mesoderm (ALPM), the primary heart tube, and subsequently the embryonic myocardium by in situ hybridisation. Loss of ogg1 resulted in severe cardiac morphogenesis and functional abnormalities, including the short heart length, arrhythmia, decreased cardiomyocytes and nkx2.5{sup +} cardiac progenitor cells. Moreover, the increased apoptosis and repressed proliferation of progenitor cells caused by ogg1 deficiency might contribute to the heart phenotype. The microarray analysis showed that the expression of genes involved in embryonic heart tube morphogenesis and heart structure were significantly changed due to the lack of ogg1. Among those, foxh1 is an important partner of ogg1 in the cardiac development in response to DNA damage. Our work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish. These findings may be helpful for understanding the aetiology of congenital cardiac deficits. - Highlights: A key DNA repair enzyme ogg1 is expressed in the embryonic heart in zebrafish. We found that ogg1 is essential for normal cardiac morphogenesis in zebrafish. The production of embryonic cardiomyocytes requires appropriate ogg1 expression. Ogg1 critically regulated proliferation of cardiac progenitor cells in zebrafish. foxh1 is a partner of ogg1 in the cardiac development in response to DNA damage.

  3. Maintaining STAR - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Getting Started Maintaining STAR VPP CampaignPosters VPP Tools VPP Presentations VPP Awareness VPP Communications VPP Conferences Maintaining STAR Email Email Page | Print Print...

  4. Installing and Maintaining a Home Solar Electric System | Department...

    Energy Savers [EERE]

    Making sure your home solar electric or photovoltaic (PV) system is sized, sited, installed, and maintained correctly is essential for maximizing its energy performance. When...

  5. Cardiolipin Deficiency in Rhodobacter sphaeroides Alters the Lipid Profile of Membranes and of Crystallized Cytochrome Oxidase, but Structure and Function Are Maintained

    SciTech Connect (OSTI)

    Zhang, Xi; Tamot, Banita; Hiser, Carrie; Reid, Gavin E.; Benning, Christoph; Ferguson-Miller, Shelagh

    2012-05-08

    Many recent studies highlight the importance of lipids in membrane proteins, including in the formation of well-ordered crystals. To examine the effect of changes in one lipid, cardiolipin, on the lipid profile and the production, function, and crystallization of an intrinsic membrane protein, cytochrome c oxidase, we mutated the cardiolipin synthase (cls) gene of Rhodobacter sphaeroides, causing a >90% reduction in cardiolipin content in vivo and selective changes in the abundances of other lipids. Under these conditions, a fully native cytochrome c oxidase (CcO) was produced, as indicated by its activity, spectral properties, and crystal characteristics. Analysis by MALDI tandem mass spectrometry (MS/MS) revealed that the cardiolipin level in CcO crystals, as in the membranes, was greatly decreased. Lipid species present in the crystals were directly analyzed for the first time using MS/MS, documenting their identities and fatty acid chain composition. The fatty acid content of cardiolipin in R. sphaeroides CcO (predominantly 18:1) differs from that in mammalian CcO (18:2). In contrast to the cardiolipin dependence of mammalian CcO activity, major depletion of cardiolipin in R. sphaeroides did not impact any aspect of CcO structure or behavior, suggesting a greater tolerance of interchange of cardiolipin with other lipids in this bacterial system.

  6. Maintaining gas cooling equipment

    SciTech Connect (OSTI)

    Rector, J.D.

    1997-05-01

    An often overlooked key to satisfactory operation and longevity of any mechanical device is proper operation and maintenance in accordance with the manufacturer`s written instructions. Absorption chillers, although they use a different technology than the more familiar vapor compression cycle to produce chilled water, operate successfully in a variety of applications if operated and maintained properly. Maintenance procedures may be more frequent than those required for vapor compression chillers, but they are also typically less complex. The goal of this article is to describe the basic operation of an absorption chiller to provide an understanding of the relatively simple tasks required to keep the machine operating at maximum efficiency for its design life and beyond. A good starting point is definitions. Gas cooling equipment is generally defined as alternative energy, non-electric cooling products. This includes absorption chillers, engine-drive chillers and packaged desiccant units, among others. Natural gas combustion drives the equipment.

  7. Tank farms essential drawing plan

    SciTech Connect (OSTI)

    Domnoske-Rauch, L.A.

    1998-08-04

    The purpose of this document is to define criteria for selecting Essential Drawings, Support Drawings, and Controlled Print File (CPF) drawings and documents for facilities that are part of East and West Tank Farms. Also, the drawings and documents that meet the criteria are compiled separate listings. The Essential Drawing list and the Support Drawing list establish a priority for updating technical baseline drawings. The CPF drawings, denoted by an asterisk (*), defined the drawings and documents that Operations is required to maintain per the TWRS Administration Manual. The Routing Boards in Buildings 272-WA and 272-AW are not part of the CPF.

  8. Policy Memorandum #9 - Establishing and Maintaining Competitive...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    9 - Establishing and Maintaining Competitive Level Codes Policy Memorandum 9 - Establishing and Maintaining Competitive Level Codes PDF icon Policy Memorandum 9 - Establishing...

  9. Hydroelectric redevelopment maintains heritage values

    SciTech Connect (OSTI)

    Bulkovshteyn, L.; Chidiac, M.; Hall, W.

    1995-12-31

    The Seymour GS is an 80 year old generating station on the historic Trent-Severn Waterway in Ontario, Canada. The rehabilitation at Seymour was approved by Provincial and Federal authorities on condition that the original appearance of the building be maintained. The capacity of the Generating Station (GS) is being uprated from 3.15 MW to 5.7 MW, by replacing five vertical double runner Francis units with five horizontal Kaplan turbines. The replacement of vertical Francis units with horizontal Kaplan units, necessitated an extensive and innovative demolition approach for the substructure modification. The new turbines required a powerhouse base slab 3.5 m below the grade of the original slab. This required removal of the existing slabs and foundation rock along with most of the interior powerhouse walls. The type of modification and demolition were carefully chosen to accommodate a very tight schedule dictated by the requirement of the Federal Department of Fisheries and Oceans (DFO), where in-water work is restricted to certain months of the year.

  10. Maintain Pumping Systems Effectively | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Maintain Pumping Systems Effectively Maintain Pumping Systems Effectively This tip sheet offers preventive and predictive actions to effectively maintain pumping systems. PUMPING SYSTEMS TIP SHEET #5 PDF icon Maintain Pumping Systems Effectively (September 2005) More Documents & Publications Minimize Compressed Air Leaks Determining the Right Air Quality for Your Compressed Air System Effect of Intake on Compressor Performance

  11. Maintaining System Air Quality | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Maintaining System Air Quality Maintaining System Air Quality This tip sheet discusses how to maintain air quality in compressed air systems through proper use of equipment. COMPRESSED AIR TIP SHEET #12 PDF icon Maintaining System Air Quality (August 2004) More Documents & Publications Remove Condensate with Minimal Air Loss Engineer End Uses for Maximum Efficiency Stabilizing System Pressure

  12. SPONAP Grant Writing Essentials

    Broader source: Energy.gov [DOE]

    HUD's Southern Plains Office of Native American Programs in collaboration with the Seminole Tribe of Florida Native Learning Center invites you to attend the Grant Writing Essentials training...

  13. Maintaining the Stockpile | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Maintaining the Stockpile NNSA ensures the Nation sustains a safe, secure, and effective nuclear deterrent through the application of science, technology, engineering, and manufacturing. To deal with the changing face of nuclear deterrence and more-widely dispersed nuclear knowledge, NNSA also ensures the United States maintains excellence in nuclear science and technology that is second to none. Within the Nuclear Security Enterprise, the central mission which includes maintaining the active

  14. Maintaining System Air Quality | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Maintaining System Air Quality (August 2004) More Documents & Publications Remove Condensate with Minimal Air Loss Engineer End Uses for Maximum Efficiency Stabilizing System...

  15. Recommendation 220: Recommendation Regarding Maintaining Funding...

    Energy Savers [EERE]

    Regarding Maintaining Funding for Cleanup The Environmental Management Site-Specific Advisory Board recommends that DOE make every effort possible, including addressing...

  16. Encapsulation method for maintaining biodecontamination activity

    DOE Patents [OSTI]

    Rogers, Robert D.; Hamilton, Melinda A.; Nelson, Lee O.; Benson, Jennifer; Green, Martin J.; Milner, Timothy N.

    2006-04-11

    A method for maintaining the viability and subsequent activity of microorganisms utilized in a variety of environments to promote biodecontamination of surfaces. One application involves the decontamination of concrete surfaces. Encapsulation of microbial influenced degradation (MID) microorganisms has shown that MID activity is effectively maintained under passive conditions, that is, without manual addition of moisture or nutrients, for an extended period of time.

  17. Encapsulation method for maintaining biodecontamination activity

    DOE Patents [OSTI]

    Rogers, Robert D.; Hamilton, Melinda A.; Nelson, Lee O.; Benson, Jennifer; Green, Martin J.; Milner, Timothy N.

    2002-01-01

    A method for maintaining the viability and subsequent activity of microorganisms utilized in a variety of environments to promote biodecontamination of surfaces. One application involves the decontamination of concrete surfaces. Encapsulation of microbial influenced degradation (MID) microorganisms has shown that MID activity is effectively maintained under passive conditions, that is, without manual addition of moisture or nutrients, for an extended period of time.

  18. Energy Literacy Essential Principle #5

    SciTech Connect (OSTI)

    2015-03-11

    Energy Literacy Essential Principle #5: Energy decisions are influenced by economic, political, environmental, and social factors.

  19. Energy Literacy Essential Principle #1

    SciTech Connect (OSTI)

    2014-12-02

    Energy Literacy Essential Principle #1: Energy is a physical quantity that follows precise natural laws.

  20. Energy Literacy Essential Principle #3

    SciTech Connect (OSTI)

    2014-12-02

    Energy Literacy Essential Principle #3: Biological processes depend on energy flow through the Earth system.

  1. Essential Body of Knowledge (EBK) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Essential Body of Knowledge (EBK) Essential Body of Knowledge (EBK) A Competency and Functional Framework For Cyber Security Workforce Development Documents Available for Download More Documents & Publications Essential Body of Knowledge (EBK) DOE CYBER SECURITY EBK: CORE COMPETENCY TRAINING REQUIREMENTS: CA DOE CYBER SECURITY EBK: MINIMUM CORE COMPETENCY TRAINING REQUIREMENTS

  2. Operating and Maintaining Your Heat Pump | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Heat & Cool Heat Pump Systems Operating and Maintaining Your Heat Pump Operating and Maintaining Your Heat Pump Changing filters regularly is an important part of maintaining ...

  3. Maintaining ideal body weight counseling sessions

    SciTech Connect (OSTI)

    Brammer, S.H.

    1980-10-09

    The purpose of this program is to provide employees with the motivation, knowledge and skills necessary to maintain ideal body weight throughout life. The target audience for this program, which is conducted in an industrial setting, is the employee 40 years of age or younger who is at or near his/her ideal body weight.

  4. Energy Literacy Essential Principle #6

    SciTech Connect (OSTI)

    2015-03-12

    Energy Literacy Essential Principle #6: The amount of energy used by human society depends on many factors.

  5. Energy Literacy Essential Principle #7

    SciTech Connect (OSTI)

    2015-03-11

    Energy Literacy Essential Principle #7: The quality of life of individuals and societies is affected by energy choices.

  6. Energy Literacy Essential Principle #2

    SciTech Connect (OSTI)

    2014-12-02

    Energy Literacy Essential Principle #2: Physical processes on Earth are the result of energy flow through the Earth system.

  7. Energy Literacy Essential Principle #4

    SciTech Connect (OSTI)

    2014-12-02

    Energy Literacy Essential Principle #4: Various sources of energy can be used to power human activities, and often this energy must be transferred from source to destination.

  8. Methods for identifying an essential gene in a prokaryotic microorganism

    DOE Patents [OSTI]

    Shizuya, Hiroaki

    2006-01-31

    Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being transformed by artificial means and is capable of undergoing DNA recombination. This system offers an enhanced means of identifying essential function genes in diploid pathogens, such as gram-negative and gram-positive bacteria.

  9. Peru struggles to maintain crude production

    SciTech Connect (OSTI)

    Not Available

    1991-01-14

    Revival of Peru's moribund oil and gas industry in the 1990s hinges on whether the new administration of President Alberto Fujimori is successful in attracting foreign investment in Peru. Fujimori's success would mean Peru pushing ahead into stepped up exploration and major development projects, such as the huge Camisea gas/condensate field discovered 2 years ago. His failure could mean Peru continuing to fall further behind in its already lagging low oil production. Huge sums of money will be needed. Peru also needs to succeed in its efforts to become creditworthy again for international agencies, foreign governments, and commercial banks. Meanwhile, Petroleos del Peru SA (Petroperu), the state oil company, will have to transfer an increasing share of its operations to private investors. But the company is likely to try to hold onto producing fields, even though it is unable to maintain full output.

  10. Proposed EPA Rules Will Cut Carbon Pollution While Maintaining...

    Energy Savers [EERE]

    Proposed EPA Rules Will Cut Carbon Pollution While Maintaining Reliability Proposed EPA Rules Will Cut Carbon Pollution While Maintaining Reliability June 3, 2014 - 4:20pm Addthis ...

  11. Fibroblasts maintained in 3 dimensions show a better differentiation state and higher sensitivity to estrogens

    SciTech Connect (OSTI)

    Montani, Claudia; Steimberg, Nathalie; Boniotti, Jennifer; Biasiotto, Giorgio; Zanella, Isabella; Diafera, Giuseppe; Biunno, Ida; Caimi, Luigi; Mazzoleni, Giovanna; Di Lorenzo, Diego

    2014-11-01

    Cell differentiation and response to hormonal signals were studied in a 3D environment on an in-house generated mouse fibroblast cell line expressing a reporter gene under the control of estrogen responsive sequences (EREs). 3D cell culture conditions were obtained in a Rotary Cell Culture System; (RCCS™), a microgravity based bioreactor that promotes the aggregation of cells into multicellular spheroids (MCS). In this bioreactor the cells maintained a better differentiated phenotype and more closely resembled in vivo tissue. The RCCS™ cultured fibroblasts showed higher expression of genes regulating cell assembly, differentiation and hormonal functions. Microarray analysis showed that genes related to cell cycle, proliferation, cytoskeleton, migration, adhesion and motility were all down-regulated in 3D as compared to 2D conditions, as well as oncogene expression and inflammatory cytokines. Controlled remodeling of ECM, which is an essential aspect of cell organization, homeostasis and tissue was affected by the culture method as assessed by immunolocalization of β-tubulin. Markers of cell organization, homeostasis and tissue repair, metalloproteinase 2 (MMP2) and its physiological inhibitor (TIMP4) changed expression in association with the relative formation of cell aggregates. The fibroblasts cultured in the RCCS™ maintain a better responsiveness to estrogens, measured as expression of ERα and regulation of an ERE-dependent reporter and of the endogenous target genes CBP, Rarb, MMP1 and Dbp. Our data highlight the interest of this 3D culture model for its potential application in the field of cell response to hormonal signals and the pharmaco-toxicological analyses of chemicals and natural molecules endowed of estrogenic potential. - Highlights: • We here characterized the first cell line derived from an estrogen reporter mouse. • In the RCCS cells express an immortalized behavior but not a transformed phenotype. • The RCCS provides a system for maintaining cells in more physiological conditions. • RCCS-cultured fibroblasts showed higher hormonal sensitivity to estradiol. • This bioreactor is a novel 3D model to be applied to pharmacotoxicological studies.

  12. EM Completes Project to Maintain Water Quality of Spent Nuclear...

    Energy Savers [EERE]

    Completes Project to Maintain Water Quality of Spent Nuclear Fuel Basin at Idaho Site EM Completes Project to Maintain Water Quality of Spent Nuclear Fuel Basin at Idaho Site ...

  13. Energy Literacy: Essential Principles and Fundamental Concepts...

    Energy Savers [EERE]

    Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy...

  14. Policy Memorandum #9 - Establishing and Maintaining Competitive Level Codes

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy 9 - Establishing and Maintaining Competitive Level Codes Policy Memorandum #9 - Establishing and Maintaining Competitive Level Codes PDF icon Policy Memorandum #9 - Establishing and Maintaining Competitive Level Codes.pdf More Documents & Publications POLICY GUIDANCE MEMORANDUM #32A Schedule A Appointments of Persons with Disabilities and Appointments for Disabled Veterans POLICY GUIDANCE MEMORANDUM #28 Requirements for Non-Competitive Reassignments into

  15. Recommendation 220: Recommendation Regarding Maintaining Funding for Cleanup

    Broader source: Energy.gov [DOE]

    The Environmental Management Site-Specific Advisory Board recommends that funding for cleanup at DOE sites should be maintained as a top priority.

  16. Maintaining nuclear stability in times of transition focus of...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Maintaining nuclear stability in times of transition focus of talk at Bradbury Science Museum Houston "Terry" Hawkins talks about the role that the nation's nuclear weapons ...

  17. Proposed EPA Rules Will Cut Carbon Pollution While Maintaining Reliability

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Energy Department is committed to supporting successful implementation of EPA’s Clean Power Plan while maintaining electric grid reliability.

  18. Operating and Maintaining Your Heat Pump | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Changing filters regularly is an important part of maintaining a heat pump system. | Photo courtesy of iStockphotoBanksPhotos Changing filters regularly is an important part...

  19. Establishing & Maintaining a Strategic Partnership with the Chief...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Establishing & Maintaining a Strategic Partnership with the Chief Financial Officer Neal Elliot of the American Council for an Energy-Efficient Economy shares insights on how to ...

  20. Idaho Application for Permit to Construct Modify or Maintain...

    Open Energy Info (EERE)

    Construct Modify or Maintain an Injection Well - Form 42-39-1 Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Idaho...

  1. Establishing & Maintaining a Strategic Partnership with the Chief Financial Officer

    Broader source: Energy.gov [DOE]

    Neal Elliot of the American Council for an Energy-Efficient Economy shares insights on how to establish and maintain a partnership with the Chief Financial Officer on this presentation.

  2. RRC - Supplemental Application Information for Permit to Maintain...

    Open Energy Info (EERE)

    Supplemental Application Information for Permit to Maintain and Use a Commercial Oil and Gas Waste Disposal Pit Jump to: navigation, search OpenEI Reference LibraryAdd to library...

  3. Installing and Maintaining a Home Solar Electric System | Department of

    Energy Savers [EERE]

    Energy Installing and Maintaining a Home Solar Electric System Installing and Maintaining a Home Solar Electric System When choosing a contractor, ask about their work record, experience, and licenses, and get more than one bid for the installation of your PV system. | Photo courtesy of Dennis Schroeder, NREL. When choosing a contractor, ask about their work record, experience, and licenses, and get more than one bid for the installation of your PV system. | Photo courtesy of Dennis

  4. Y-12 Construction maintains 'superb' safety performance | Y-12 National

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Security Complex Construction maintains ... Y-12 Construction maintains 'superb' safety performance Posted: March 6, 2013 - 6:03pm Tom Morris, B&W Y-12 vice president of projects, presents Construction's safety awards to Monica Lewis, Y-12 craft safety lead representative, and Kevin Adkisson, Knoxville Building and Construction Trades Council president. At a recent celebration, B&W Y-12's Direct-Hire Construction team was honored for two major safety achievements: more than one

  5. Essential Innovations Technology Corp | Open Energy Information

    Open Energy Info (EERE)

    Technology Corp Jump to: navigation, search Name: Essential Innovations Technology Corp Place: Bellingham,, Washington State Zip: 98225 Sector: Geothermal energy, Services Product:...

  6. Energy Literacy: Essential Principles and Fundamental Concepts...

    Broader source: Energy.gov (indexed) [DOE]

    Literacy: Essential Principles and Fundamental Concepts for Energy Education News and Updates Check out our new Energy Literacy video series The Energy Literacy Framework is also ...

  7. Method and apparatus for maintaining equilibrium in a helical axis stellarator

    DOE Patents [OSTI]

    Reiman, A.; Boozer, A.

    1984-10-31

    Apparatus for maintaining three-dimensional MHD equilibrium in a plasma contained in a helical axis stellarator includes a resonant coil system, having a configuration such that current therethrough generates a magnetic field cancelling the resonant magnetic field produced by currents driven by the plasma pressure on any given flux surface resonating with the rotational transform of another flux surface in the plasma. Current through the resonant coil system is adjusted as a function of plasma beta.

  8. Method and apparatus for maintaining equilibrium in a helical axis stellarator

    DOE Patents [OSTI]

    Reiman, Allan; Boozer, Allen

    1987-01-01

    Apparatus for maintaining three-dimensional MHD equilibrium in a plasma contained in a helical axis stellerator includes a resonant coil system, having a configuration such that current therethrough generates a magnetic field cancelling the resonant magnetic field produced by currents driven by the plasma pressure on any given flux surface resonating with the rotational transform of another flux surface in the plasma. Current through the resonant coil system is adjusted as a function of plasma beta.

  9. Installing and Maintaining a Small Wind Electric System | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Small Wind Electric System Installing and Maintaining a Small Wind Electric System Installing and Maintaining a Small Wind Electric System If you went through the planning steps to evaluate whether a small wind electric system will work at your location, you will already have a general idea about: The amount of wind at your site The zoning requirements and covenants in your area The economics, payback, and incentives of installing a wind system at your site. Now, it is time to look at

  10. Weatherization Guidance on Maintaining Privacy of Recipients of Services

    Broader source: Energy.gov [DOE]

    U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Weatherization Assistance Program Notice 10-08 dealing with requirements of weatherization service providers to maintain the privacy of low-income residents receiving energy efficiency services in their homes.

  11. LED Essentials - Technology, Applications, Advantages, Disadvantages |

    Energy Savers [EERE]

    Department of Energy Essentials - Technology, Applications, Advantages, Disadvantages LED Essentials - Technology, Applications, Advantages, Disadvantages On October 11, 2007, Kevin Dowling, VP of Innovation for Philips Solid-State Lighting Solutions, presented a broad introduction to LED technology, and discussed the technology status, advantages and disadvantages, current applications, future potential, and evolving path of LED technology from indicator lights to general illumination. View

  12. A RAM (Reliability, Availability and Maintainability) analysis of the proposed Tinker AFB Jet Fuel Storage Tank Facility. [Reliability, Availability, and Maintainability

    SciTech Connect (OSTI)

    Wright, R.E.; Sattison, M.B.

    1987-08-01

    The purpose of this study is to determine the Reliability, Availability and Maintainability (RAM) at the 30% design phase of a Jet Fuel Storage Tank Facility that is to be installed at the Tinker Air Force Base, Tulsa, Oklahoma. The Jet Fuel Storage Tank Facility was divided into four subsystems: Fuel Storage and Pipeline Transfer Pumps; Truck Unloading and Loading; Fire Protection (foam and water supply systems); and Electric Power. The RAM analysis was performed on four functions of these subsystems: transferring fuel from the two new 55K barrel storage tanks to the existing fuel pipeline system; transferring fuel from the two 55K barrel storage tanks to the aircraft refueler trucks; transferring fuel from the road transport trucks to the aircraft refueler trucks; and fire protection. A fault tree analysis was performed on each functional system. The quantification was performed for several mission times.

  13. Compact, maintainable 80-KeV neutral beam module

    DOE Patents [OSTI]

    Fink, Joel H. (Livermore, CA); Molvik, Arthur W. (Livermore, CA)

    1980-01-01

    A compact, maintainable 80-keV arc chamber, extractor module for a neutral beam system immersed in a vacuum of <10.sup.-2 Torr, incorporating a nested 60-keV gradient shield located midway between the high voltage ion source and surrounding grounded frame. The shield reduces breakdown or arcing path length without increasing the voltage gradient, tends to keep electric fields normal to conducting surfaces rather than skewed and reduces the peak electric field around irregularities on the 80-keV electrodes. The arc chamber or ion source is mounted separately from the extractor or ion accelerator to reduce misalignment of the accelerator and to permit separate maintenance to be performed on these systems. The separate mounting of the ion source provides for maintaining same without removing the ion accelerator.

  14. Installing and Maintaining a Home Solar Electric System | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Home Solar Electric System Installing and Maintaining a Home Solar Electric System When choosing a contractor, ask about their work record, experience, and licenses, and get more than one bid for the installation of your PV system. | Photo courtesy of Dennis Schroeder, NREL. When choosing a contractor, ask about their work record, experience, and licenses, and get more than one bid for the installation of your PV system. | Photo courtesy of Dennis Schroeder, NREL. Making sure your

  15. Maintaining History of the ARM Climate Research Facility Data

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Maintaining History of the ARM Climate Research Facility Data Koontz, Annette Pacific Northwest National Laboratory Sivaraman, Chitra Pacific Northwest National Laboratory Martin, Tonya DOE/Pacific Northwest National Laboratory Category: Infrastructure & Outreach The Data Management Facility (DMF), located at Pacific Northwest National Laboratory, is the central collection point for the ARM Climate Research Facility (ACRF) data for both ingests and Value Added Products. At the present time,

  16. Energy Literacy: Essential Principle #1 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1 Energy Literacy: Essential Principle #1 Addthis Essential Principle #1 - Energy is a physical quantity that follows precise natural laws

  17. Energy Literacy: Essential Principle #3 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    3 Energy Literacy: Essential Principle #3 Addthis Essential Principle #3 - Biological processes depend on energy flow through

  18. Oscillatory nonohomic current drive for maintaining a plasma current

    DOE Patents [OSTI]

    Fisch, N.J.

    1984-01-01

    Apparatus and methods are described for maintaining a plasma current with an oscillatory nonohmic current drive. Each cycle of operation has a generation period in which current driving energy is applied to the plasma, and a relaxation period in which current driving energy is removed. Plasma parameters, such as plasma temperature or plasma average ionic charge state, are modified during the generation period so as to oscillate plasma resistivity in synchronism with the application of current driving energy. The invention improves overall current drive efficiencies.

  19. Oscillatory nonhmic current drive for maintaining a plasma current

    DOE Patents [OSTI]

    Fisch, Nathaniel J.

    1986-01-01

    Apparatus and method of the invention maintain a plasma current with an oscillatory nonohmic current drive. Each cycle of operation has a generation period in which current driving energy is applied to the plasma, and a relaxation period in which current driving energy is removed. Plasma parameters, such as plasma temperature or plasma average ionic charge state, are modified during the generation period so as to oscillate plasma resistivity in synchronism with the application of current driving energy. The invention improves overall current drive efficiencies.

  20. Application of systems engineering techniques (reliability, availability, maintainability, and dollars) to the Gas Centrifuge Enrichment Plant

    SciTech Connect (OSTI)

    Boylan, J.G.; DeLozier, R.C.

    1982-01-01

    The systems engineering function for the Gas Centrifuge Enrichment Plant (GCEP) covers system requirements definition, analyses, verification, technical reviews, and other system efforts necessary to assure good balance of performance, safety, cost, and scheduling. The systems engineering function will support the design, installation, start-up, and operational phases of GCEP. The principal objectives of the systems engineering function are to: assure that the system requirements of the GCEP process are adequately specified and documented and that due consideration and emphasis are given to all aspects of the project; provide system analyses of the designs as they progress to assure that system requirements are met and that GCEP interfaces are compatible; assist in the definition of programs for the necessary and sufficient verification of GCEP systems; and integrate reliability, maintainability, logistics, safety, producibility, and other related specialties into a total system effort. This paper addresses the GCEP reliability, availability, maintainability, and dollars (RAM dollars) analyses which are the primary systems engineering tools for the development and implementation of trade-off studies. These studies are basic to reaching cost-effective project decisions. The steps necessary to achieve optimum cost-effective design are shown.

  1. Guide to Operating and Maintaining EnergySmart Schools

    SciTech Connect (OSTI)

    2010-01-01

    Through a commitment to high performance, school districts are discovering that smart energy choices can create lasting benefits for students, communities, and the environment. For example, an energy efficient school district with 4,000 students can save as much as $160,000 a year in energy costs. Over 10 years, those savings can reach $1.6 million, translating into the ability to hire more teachers, purchase more textbooks and computers, or invest in additional high performance facilities. Beyond these bottomline benefits, schools can better foster student health, decrease absenteeism, and serve as centers of community life. The U.S. Department of Energy's EnergySmart Schools Program promotes a 30 percent improvement in existing school energy use. It also encourages the building of new schools that exceed code (ASHRAE 90.11999) by 50 percent or more. The program provides resources like this Guide to Operating and Maintaining EnergySmart Schools to assist school decisionmakers in planning, financing, operating, and maintaining energy efficient, high performance schools. It also offers education and training for building industry professionals. Operations and maintenance refer to all scheduled and unscheduled actions for preventing equipment failure or decline with the goal of increasing efficiency, reliability, and safety. A preventative maintenance program is the organized and planned performance of maintenance activities in order to prevent system or production problems or failures from occurring. In contrast, deferred maintenance or reactive maintenance (also called diagnostic or corrective maintenance) is conducted to address an existing problem. This guide is a primary resource for developing and implementing a districtor schoolwide operations and maintenance (O&M) program that focuses on energy efficiency. The EnergySmart Schools Solutions companion CD contains additional supporting information for design, renovation, and retrofit projects. The objective of this guide is to provide organizational and technical information for integrating energy and high performance facility management into existing O&M practices. The guide allows users to adapt and implement suggested O&M strategies to address specific energy efficiency goals. It recognizes and expands on existing tools and resources that are widely used throughout the high performance school industry. External resources are referenced throughout the guide and are also listed within the EnergySmart Schools O&M Resource List (Appendix J). While this guide emphasizes the impact of the energy efficiency component of O&M, it encourages taking a holistic approach to maintaining a high-performance school. This includes considering various environmental factors where energy plays an indirect or direct role. For example, indoor air quality, site selection, building orientation, and water efficiency should be considered. Resources to support these overlapping aspects will be cited throughout the guide.

  2. Can Canister Containment Be Maintained After Accidental Drop Events?

    SciTech Connect (OSTI)

    D. K. Morton; S. D. Snow; T. E. Rahl; R. K. Blandford; T. J. Hill

    2006-05-01

    The National Spent Nuclear Fuel Program (NSNFP) has pursued a number of structural testing projects that are intended to provide data that can be used to substantiate the position that U. S. Department of Energy (DOE) spent nuclear fuel (SNF) canisters, made from austenitic stainless steels, can maintain containment after an accidental drop event and that plastic finite element methods can be used to accurately predict the structural response of canister configurations not specifically tested. In particular, drop tests of full-scale canisters and material impact testing at varying strain rates reflecting accidental drop conditions have been completed or are in progress. This paper provides insights to conclusions achieved to date and what efforts are planned to fully address the pertinent issues necessary to demonstrate the safety of DOE SNF canisters subjected to accidental drop events.

  3. Reliability and Maintainability Data for Liquid Metal Cooling Systems

    SciTech Connect (OSTI)

    Cadwallader, Lee Charles

    2015-05-01

    One of the coolants of interest for future fusion breeding blankets is lead-lithium. As a liquid metal it offers the advantages of high temperature operation for good station efficiency, low pressure, and moderate flow rate. This coolant is also under examination for use in test blanket modules to be used in the ITER international project. To perform reliability, availability, maintainability and inspectability (RAMI) assessment as well as probabilistic safety assessment (PSA) of lead-lithium cooling systems, component failure rate data are needed to quantify the system models. RAMI assessment also requires repair time data and inspection time data. This paper presents a new survey of the data sets that are available at present to support RAMI and PSA quantification. Recommendations are given for the best data values to use when quantifying system models.

  4. Energy Literacy: Essential Principle #2 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 Energy Literacy: Essential Principle #2 Addthis Essential Principle #2 - Physical processes on Earth are the result of energy flow through

  5. Energizing the "K-Gray" Community: Energy Literacy Essential...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energizing the "K-Gray" Community: Energy Literacy Essential Principles and Fundamental Concepts Energizing the "K-Gray" Community: Energy Literacy Essential Principles and ...

  6. Text-Alternative Version: LED Essentials- Technology, Applications, Advantages, Disadvantages

    Broader source: Energy.gov [DOE]

    Below is the text-alternative version of the LED Essentials - Technology, Applications, Advantages, Disadvantages webcast.

  7. Method for maintaining a cutting blade centered in a kerf

    DOE Patents [OSTI]

    Blaedel, Kenneth L.; Davis, Pete J.; Landram, Charles S.

    2002-01-01

    A saw having a self-pumped hydrodynamic blade guide or bearing for retaining the saw blade in a centered position in the saw kerf (width of cut made by the saw). The hydrodynamic blade guide or bearing utilizes pockets or grooves incorporated into the sides of the blade. The saw kerf in the workpiece provides the guide or bearing stator surface. Both sides of the blade entrain cutting fluid as the blade enters the kerf in the workpiece, and the trapped fluid provides pressure between the blade and the workpiece as an inverse function of the gap between the blade surface and the workpiece surface. If the blade wanders from the center of the kerf, then one gap will increase and one gap will decrease and the consequent pressure difference between the two sides of the blade will cause the blade to re-center itself in the kerf. Saws using the hydrodynamic blade guide or bearing have particular application in slicing slabs from boules of single crystal materials, for example, as well as for cutting other difficult to saw materials such as ceramics, glass, and brittle composite materials.

  8. PHMC Year 2000: Status reporting for mission essential Year 2000 projects. Revision 0, Volume 3

    SciTech Connect (OSTI)

    Layfield, K.A.

    1998-09-02

    The PHMC Year 2000 status reporting process is designed to encompass the reporting requirements of the Office of Management and Budget (OMB), DOE HQ, RL and the PHMC for mission essential Year 2000 projects. Status reporting is required for all Year 2000 projects. The Year 2000 project list will be maintained current as Year 2000 projects are modified, added or deleted. Reporting is required until a Year 2000 project has completed compliance assurance. Some projects will be identified as DOE HQ reportable. These are projects determined to be the most critical and due the attention of DOE HQ.

  9. Energy Literacy: Essential Principle #4 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    4 Energy Literacy: Essential Principle #4 Addthis Essential Principle #4 - Various sources of energy can be used to power human activities, and often this energy must be transferred from source to destination

  10. Guide to Operating and Maintaining EnergySmart Schools | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Guide to Operating and Maintaining EnergySmart Schools Guide to Operating and Maintaining EnergySmart Schools This guide is a primary resource for developing and implementing a district- or school- wide operations and maintenance (O&M) program that focuses on energy efficiency. PDF icon ess_o-and-m-guide.pdf More Documents & Publications Reduce Operating Costs with an EnergySmart School Project EnergySmart Schools Tips: Retrofitting, Operating, and Maintaining Existing

  11. Energy Literacy: Essential Principles and Fundamental Concepts for Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Education | Department of Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education News and Updates Check out our new Energy Literacy video series! The Energy Literacy Framework is also available in Spanish: Conocimiento de Energía. What is Energy Literacy? Energy Literacy is an understanding of the

  12. Essential Body of Knowledge (EBK) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Services » Training » Cybersecurity Training Warehouse » DOE Training & Education » Essential Body of Knowledge (EBK) Essential Body of Knowledge (EBK) Train12.jpg The OCIO has developed a DOE-specific Essential Body of Knowledge (EBK) using DOE cybersecurity policy, industry best practices and lessons learned, and comprehensive internal needs assessments to identify fundamental cybersecurity roles and associated responsibilities. Core competencies, as identified and documented in the

  13. Biosurveillance panel to address essential science for public health

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Panel to address essential science for public health Biosurveillance panel to address essential science for public health A team of national experts across varied disciplines will be gathering Feb. 17 in Chicago, prepared to explore the most critical aspects of international disease awareness. February 17, 2014 Basil Swanson Basil Swanson Contact Nancy Ambrosiano Communications Office (505) 699-1149 Email "It is absolutely essential that nations are able to quickly detect and characterize a

  14. Interim Stabilization Equipment Essential and Support Drawing Plan

    SciTech Connect (OSTI)

    KOCH, M.R.

    1999-10-22

    The purpose of this document is to list the Interim Stabilization equipment drawings that are classified as Essential or Support drawings. Essential Drawings: Those drawings identified by the facility staff as necessary to directly support the safe operation of the facility or equipment. Support Drawings: Those drawings identified by the facility staff that further describe the design details of structures, systems or components shown on essential drawings.

  15. Energy Literacy Social Studies Guide - Essential Principle 5...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    5 Energy Literacy Social Studies Guide - Essential Principle 5 Below is information about ... Energy decisions are influenced by economic, political, environmental, and social factors. ...

  16. Energy Literacy Social Studies Guide - Essential Principle 4...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    4 Energy Literacy Social Studies Guide - Essential Principle 4 Below is information about ... Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences ...

  17. Energy Literacy Social Studies Guide - Essential Principle 2...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 Energy Literacy Social Studies Guide - Essential Principle 2 Below is information about ... Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences ...

  18. Energy Literacy Social Studies Guide - Essential Principle 1...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1 Energy Literacy Social Studies Guide - Essential Principle 1 Below is information about ... follows precise natural laws. Curriculum Social Studies Time Required 3-4 class periods ...

  19. Energy Literacy Social Studies Guide - Essential Principle 3...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    3 Energy Literacy Social Studies Guide - Essential Principle 3 Below is information about ... Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences ...

  20. Energy Literacy Social Studies Guide - Essential Principle 7...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    impact the environment? Summary Discussion points related to Essential Principle 7: The quality of life of individuals and societies is affected by energy choices. Curriculum...

  1. Essential Innovations Ekistics Town Planning Jiangsu Sifang Culture...

    Open Energy Info (EERE)

    Geothermal energy Product: Announced in October 2006, this is a JV between Essential Innovation of Canada, Ekistics Town Planning also of Canada, and Jiangsu Sifang Culture...

  2. Maintaining molten salt electrolyte concentration in aluminum-producing electrolytic cell

    DOE Patents [OSTI]

    Barnett, Robert J.; Mezner, Michael B.; Bradford, Donald R

    2005-01-04

    A method of maintaining molten salt concentration in a low temperature electrolytic cell used for production of aluminum from alumina dissolved in a molten salt electrolyte contained in a cell free of frozen crust wherein volatile material is vented from the cell and contacted and captured on alumina being added to the cell. The captured volatile material is returned with alumina to cell to maintain the concentration of the molten salt.

  3. DOE-TSPP-7-2013, Maintaining DOE Technical Standards | Department of Energy

    Energy Savers [EERE]

    7-2013, Maintaining DOE Technical Standards DOE-TSPP-7-2013, Maintaining DOE Technical Standards Technical Standards Program Procedures (TSPP) - September 16, 2013 This Procedure provides guidance for the routine maintenance of the Department of Energy (DOE) Technical Standards. This Procedure applies to all DOE Headquarters and field organizations, management and operating contractors, and laboratories (hereafter referred to collectively as Technical Standards Program (TSP) participants)

  4. Remote sensing-based characterization of plant functional type...

    Office of Scientific and Technical Information (OSTI)

    Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral...

  5. Remote sensing-based characterization of plant functional type

    Office of Scientific and Technical Information (OSTI)

    Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral...

  6. Energy Literacy Social Studies Guide - Essential Principle 6...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Subject How much energy do I need? Summary Discussion points related to Essential Principle 6: The amount of energy used by human society depends on many factors. Curriculum Social ...

  7. The Need for Essential Consumer Protections: Smart metering proposals...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and the move to time-based pricing. August 2010 The Need for Essential Consumer Protections: Smart metering proposals and the move to time-based pricing. August 2010 There ...

  8. The Need for Essential Consumer Protections: Smart Metering Proposals...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Metering Proposals and the Move to Time-Based Pricing The Need for Essential Consumer Protections: Smart Metering Proposals and the Move to Time-Based Pricing There is a widespread ...

  9. Energy Literacy Social Studies Guide – Essential Principle 7

    K-12 Energy Lesson Plans and Activities Web site (EERE)

    A guide for social studies educators using the Energy Literacy framework and videos. Includes discussion points related to Essential Principle 7: "The quality of life of individuals and societies is affected by energy choices."

  10. ITP Chemicals: Chemical Industry of the Future: New Biocatalysts: Essential

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Tools for a Sustainable 21st Century Chemical Industry | Department of Energy Chemical Industry of the Future: New Biocatalysts: Essential Tools for a Sustainable 21st Century Chemical Industry ITP Chemicals: Chemical Industry of the Future: New Biocatalysts: Essential Tools for a Sustainable 21st Century Chemical Industry PDF icon biocatalysis_roadmap.pdf More Documents & Publications TECHNOLOGY VISION 2020: The U.S. Chemical Industry Gasoline Biodesulfurization Fact Sheet Breaking the

  11. Wide Bandgap Semiconductors: Essential to Our Technology Future |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Wide Bandgap Semiconductors: Essential to Our Technology Future Wide Bandgap Semiconductors: Essential to Our Technology Future January 15, 2014 - 8:00am Addthis Learn how wide bandgap semiconductors could impact clean energy technology and our daily lives. | Video by Sarah Gerrity and Matty Greene, Energy Department. Dr. Ernest Moniz Dr. Ernest Moniz Secretary of Energy What are the key facts? North Carolina State University will lead the Energy Department's new

  12. EERE Success Story-Rhode Island Schools Teach Energy Essentials |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Rhode Island Schools Teach Energy Essentials EERE Success Story-Rhode Island Schools Teach Energy Essentials December 10, 2015 - 11:24am Addthis Students participating in the NEED Project at Scituate High and Calcutt Middle Schools planted 14 trees in Central Falls, Rhode Island. Photo Courtesy | Rhode Island Public Schools Students participating in the NEED Project at Scituate High and Calcutt Middle Schools planted 14 trees in Central Falls, Rhode Island. Photo

  13. Energy Literacy Social Studies Guide - Essential Principle 1 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 1 Energy Literacy Social Studies Guide - Essential Principle 1 Below is information about the student activity/lesson plan from your search. Grades 9-12 Subject How should the United States deal with nuclear waste? Summary Discussion points related to Essential Principle 1: Energy is a physical quantity that follows precise natural laws. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson Plans/Activity PDF icon

  14. Energy Literacy Social Studies Guide - Essential Principle 4 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 4 Energy Literacy Social Studies Guide - Essential Principle 4 Below is information about the student activity/lesson plan from your search. Grades 9-12 Summary Discussion points related to Essential Principle 4: Various sources of energy can be used to power human activities, and often this energy must be transferred from source to destination. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson Plans/Activity PDF icon

  15. Genetic and structural analysis of the essential fission yeast RNA

    Office of Scientific and Technical Information (OSTI)

    polymerase II CTD phosphatase Fcp1 (Journal Article) | SciTech Connect SciTech Connect Search Results Journal Article: Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1 Citation Details In-Document Search Title: Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1 Authors: Schwer, Beate ; Ghosh, Agnidipta ; Sanchez, Ana M. ; Lima, Christopher D. ; Shuman, Stewart [1] ; SKI) [2] + Show Author

  16. Coherence resonance in excitable and oscillatory systems: The essential

    Office of Scientific and Technical Information (OSTI)

    role of slow and fast dynamics (Journal Article) | SciTech Connect Journal Article: Coherence resonance in excitable and oscillatory systems: The essential role of slow and fast dynamics Citation Details In-Document Search Title: Coherence resonance in excitable and oscillatory systems: The essential role of slow and fast dynamics Stochastic noise of an appropriate amplitude can maximize the coherence of the dynamics of certain types of excitable systems via a phenomenon known as coherence

  17. Energy Department Helps Rhode Island Schools Teach Energy Essentials |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Helps Rhode Island Schools Teach Energy Essentials Energy Department Helps Rhode Island Schools Teach Energy Essentials September 21, 2015 - 4:17pm Addthis Students participating in the NEED Project at Scituate High and Calcutt Middle Schools planted 14 trees in Central Falls, Rhode Island. Students participating in the NEED Project at Scituate High and Calcutt Middle Schools planted 14 trees in Central Falls, Rhode Island. Calcutt Middle School students in Rhode Island

  18. Energy Literacy Social Studies Guide - Essential Principle 2 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 2 Energy Literacy Social Studies Guide - Essential Principle 2 Below is information about the student activity/lesson plan from your search. Grades 9-12 Subject How has water shaped human settlement? Summary Discussion points related to Essential Principle 2: Physical processes on Earth are the result of energy flow through the Earth system. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson Plans/Activity PDF icon

  19. Energy Literacy Social Studies Guide - Essential Principle 5 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 5 Energy Literacy Social Studies Guide - Essential Principle 5 Below is information about the student activity/lesson plan from your search. Grades 9-12 Subject Should the U.S. Government subsidize specific energy initiatives? Summary Discussion points related to Essential Principle 5: Energy decisions are influenced by economic, political, environmental, and social factors. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson

  20. Recommendations to the NRC on human engineering guidelines for nuclear power plant maintainability

    SciTech Connect (OSTI)

    Badalamente, R.V.; Fecht, B.A.; Blahnik, D.E.; Eklund, J.D.; Hartley, C.S.

    1986-03-01

    This document contains human engineering guidelines which can enhance the maintainability of nuclear power plants. The guidelines have been derived from general human engineering design principles, criteria, and data. The guidelines may be applied to existing plants as well as to plants under construction. They apply to nuclear power plant systems, equipment and facilities, as well as to maintenance tools and equipment. The guidelines are grouped into seven categories: accessibility and workspace, physical environment, loads and forces, maintenance facilities, maintenance tools and equipment, operating equipment design, and information needs. Each chapter of the document details specific maintainability problems encountered at nuclear power plants, the safety impact of these problems, and the specific maintainability design guidelines whose application can serve to avoid these problems in new or existing plants.

  1. Save Money and Stay Cool with an Efficient, Well-Maintained Air Conditioner

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy Money and Stay Cool with an Efficient, Well-Maintained Air Conditioner Save Money and Stay Cool with an Efficient, Well-Maintained Air Conditioner June 29, 2010 - 7:30am Addthis Eric Barendsen Energy Technology Program Specialist, Office of Energy Efficiency and Renewable Energy OK. It's officially summer here in Washington, D.C. I'm seeking the coolest, shadiest places possible as I get ready for the hottest few months of the year. It's already been a hot June in much

  2. Reduced expression of Autographa californica nucleopolyhedrovirus ORF34, an essential gene, enhances heterologous gene expression

    SciTech Connect (OSTI)

    Salem, Tamer Z.; Department of Microbial Molecular Biology, AGERI, Agricultural Research Center, Giza 12619; Division of Biomedical Sciences, Zewail University, Zewail City of Science and Technology, Giza 12588 ; Zhang, Fengrui; Thiem, Suzanne M.

    2013-01-20

    Autographa californica multiple nucleopolyhedrovirus ORF34 is part of a transcriptional unit that includes ORF32, encoding a viral fibroblast growth factor (FGF) and ORF33. We identified ORF34 as a candidate for deletion to improve protein expression in the baculovirus expression system based on enhanced reporter gene expression in an RNAi screen of virus genes. However, ORF34 was shown to be an essential gene. To explore ORF34 function, deletion (KO34) and rescue bacmids were constructed and characterized. Infection did not spread from primary KO34 transfected cells and supernatants from KO34 transfected cells could not infect fresh Sf21 cells whereas the supernatant from the rescue bacmids transfection could recover the infection. In addition, budded viruses were not observed in KO34 transfected cells by electron microscopy, nor were viral proteins detected from the transfection supernatants by western blots. These demonstrate that ORF34 is an essential gene with a possible role in infectious virus production.

  3. Method and apparatus for maintaining the pH in zinc-bromine battery systems

    DOE Patents [OSTI]

    Grimes, Patrick G.

    1985-09-10

    A method and apparatus for maintaining the pH level in a zinc-bromine battery features reacting decomposition hydrogen with bromine in the presence of a catalyst. The catalyst encourages the formation of hydrogen and bromine ions. The decomposition hydrogen is therefore consumed, alloying the pH of the system to remain substantially at a given value.

  4. EM Completes Project to Maintain Water Quality of Spent Nuclear Fuel Basin at Idaho Site

    Broader source: Energy.gov [DOE]

    IDAHO FALLS, Idaho – EM and its main cleanup contractor at DOE’s Idaho Site recently reached a major project milestone necessary to maintain water quality and continued, safe operations within the site’s spent nuclear fuel storage basin.

  5. Thermal element for maintaining minimum lamp wall temperature in fluorescent fixtures

    DOE Patents [OSTI]

    Siminovitch, Michael J.

    1992-01-01

    In a lighting fixture including a lamp and a housing, an improvement is disclosed for maintaining a lamp envelope area at a cooler, reduced temperature relative to the enclosed housing ambient. The improvement comprises a thermal element in thermal communication with the housing extending to and springably urging thermal communication with a predetermined area of the lamp envelope surface.

  6. Thermal element for maintaining minimum lamp wall temperature in fluorescent fixtures

    DOE Patents [OSTI]

    Siminovitch, M.J.

    1992-11-10

    In a lighting fixture including a lamp and a housing, an improvement is disclosed for maintaining a lamp envelope area at a cooler, reduced temperature relative to the enclosed housing ambient. The improvement comprises a thermal element in thermal communication with the housing extending to and springably urging thermal communication with a predetermined area of the lamp envelope surface. 12 figs.

  7. Healthy and Affordable Housing: Practical Recommendations for Building, Renovating and Maintaining Housing: Read This Before You Move In

    SciTech Connect (OSTI)

    2001-09-06

    This document provides advice for healthy and affordable housing: practical recommendations for building, renovating, and maintaining housing.

  8. Energy Literacy Social Studies Guide - Essential Principle 6 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 6 Energy Literacy Social Studies Guide - Essential Principle 6 Below is information about the student activity/lesson plan from your search. Grades 9-12 Subject How much energy do I need? Summary Discussion points related to Essential Principle 6: The amount of energy used by human society depends on many factors. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson Plans/Activity PDF icon EL6_SocStudiesGuides_AGI.pdf More Documents

  9. Energy Literacy Social Studies Guide - Essential Principle 3 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 3 Energy Literacy Social Studies Guide - Essential Principle 3 Below is information about the student activity/lesson plan from your search. Grades 9-12 Subject Where does our food come from? Summary Discussion points related to Essential Principle 3: Biological processes depend on energy flow through the Earth system. Curriculum Social Studies Time Required 3-4 class periods Owner American Geosciences Institute Lesson Plans/Activity PDF icon EL3_SocStudiesGuides_AGI.pdf More

  10. Methods and devices for maintaining a resonant wavelength of a photonic microresonator

    DOE Patents [OSTI]

    Jones, Adam; Zortman, William A.

    2015-07-14

    A photonic microresonator incorporates a localized heater element within a section of an optical bus waveguide that is in proximity to the resonator structure. The application of an adjustable control voltage to the heater element provides a localized change in the refractive index value of the bus waveguide, compensating for temperature-induced wavelength drift and maintaining a stabilized value of the microresonator's resonant wavelength.

  11. Functional nucleic acid probes and uses thereof

    DOE Patents [OSTI]

    Nilsen-Hamilton, Marit

    2006-10-03

    The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least one functional nucleic acid, at least one regulating nucleic acid, and at least one attenuator. The functional nucleic acid is maintained in an inactive state by the attenuator and activated by the regulating nucleic acid only in the presence of a regulating nucleic acid target. In its activated state the functional nucleic acid can bind to its target to carry out a desired function, such as generating a signal, cleaving a nucleic acid, or catalyzing a reaction.

  12. Apparatus and method for maintaining low temperatures about an object at a remote location. [Patent application

    DOE Patents [OSTI]

    Steyert, W.A. Jr.; Overton, W.C. Jr.

    1980-10-29

    The disclosure is directed to an apparatus and method for maintaining a body at cryogenic temperatures at a remote location such as down a borehole for an extended period of time. A housing contains a body comprising a material having a high specific heat at cryogenic temperatures such as between about 2 and 15 K. The body contains an orifice for containing an instrument or instruments operable at superconducting temperatures. The apparatus is precooled at the surface and lowered into a borehole to a desired depth, such as 2 to 3 miles. The instruments are operated, and the apparatus withdrawn, the material of the body maintaining the very low temperatures at which the instrument(s) operate for a sufficient period of time at the remote or downhole location. The material may comprise a rare earth compound, such as Gd/sub 2/O/sub 3/, Gd/sub 2/Se/sub 3/, Gd/sub 2/O/sub 2/S or GdAlO/sub 3/. Monoclinic and C-phase gadolinium oxides work well. A low temperature is maintainable at a remote location for several hours.

  13. Long-Term Surveillance and Maintenance Records: Maintaining Access to the Knowledge - 13122

    SciTech Connect (OSTI)

    Montgomery, John; Gueretta, Jeanie; McKinney, Ruth; Anglim, Cliff

    2013-07-01

    The U.S. Department of Energy (DOE) Office of Legacy Management (LM) is an integral part of DOE's strategy to ensure that legacy liabilities of former nuclear weapons production sites are properly managed following the completion of environmental cleanup activities. In the area of environmental legacy management, records management is crucial to the protection of health, environmental, and legal interests of the Department and the public. LM is responsible for maintaining long-term surveillance and maintenance (LTS and M) records in performance of its mission. Maintaining access to the knowledge contained in these record collections is one of LM's primary responsibilities. To fulfill this responsibility, LM established a consolidated records management facility, the LM Business Center (LMBC), to house physical media records and electronic records. A new electronic record keeping system (ERKS) was needed to replace an obsolete system while helping to ensure LM is able to meet ongoing responsibilities to maintain access to knowledge and control the life cycle management of records. (authors)

  14. The reticulons: Guardians of the structure and function of the endoplasmic reticulum

    SciTech Connect (OSTI)

    Di Sano, Federica; Bernardoni, Paolo; Piacentini, Mauro; National Institute for Infectious Diseases, IRCCS 'L. Spallanzani', Via Portuense, 00149 Rome

    2012-07-01

    The endoplasmic reticulum (ER) consists of the nuclear envelope and a peripheral network of tubules and membrane sheets. The tubules are shaped by a specific class of curvature stabilizing proteins, the reticulons and DP1; however it is still unclear how the sheets are assembled. The ER is the cellular compartment responsible for secretory and membrane protein synthesis. The reducing conditions of ER lead to the intra/inter-chain formation of new disulphide bonds into polypeptides during protein folding assessed by enzymatic or spontaneous reactions. Moreover, ER represents the main intracellular calcium storage site and it plays an important role in calcium signaling that impacts many cellular processes. Accordingly, the maintenance of ER function represents an essential condition for the cell, and ER morphology constitutes an important prerogative of it. Furthermore, it is well known that ER undergoes prominent shape transitions during events such as cell division and differentiation. Thus, maintaining the correct ER structure is an essential feature for cellular physiology. Now, it is known that proper ER-associated proteins play a fundamental role in ER tubules formation. Among these ER-shaping proteins are the reticulons (RTN), which are acquiring a relevant position. In fact, beyond the structural role of reticulons, in very recent years new and deeper functional implications of these proteins are emerging in relation to their involvement in several cellular processes.

  15. The Need for Essential Consumer Protections: Smart Metering Proposals and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Move to Time-Based Pricing | Department of Energy Metering Proposals and the Move to Time-Based Pricing The Need for Essential Consumer Protections: Smart Metering Proposals and the Move to Time-Based Pricing There is a widespread consensus that the U.S. distribution and transmission systems for vital electricity service need to be modernized and upgraded to handle not only load growth, but the integration of renewable resources and the potential for a significant increase in

  16. Location of the essential spectrum in curved quantum layers

    SciTech Connect (OSTI)

    Krejčiřík, David; Lu, Zhiqin

    2014-08-15

    We consider the Dirichlet Laplacian in tubular neighbourhoods of complete non-compact Riemannian manifolds immersed in the Euclidean space. We show that the essential spectrum coincides with the spectrum of a planar tube provided that the second fundamental form of the manifold vanishes at infinity and the transport of the cross-section along the manifold is asymptotically parallel. For low dimensions and codimension, the result applies to the location of propagating states in nanostructures under physically natural conditions.

  17. Three-phase uninterruptible power supply maintaining reserve energy sources in idling condition with unbalanced loads

    SciTech Connect (OSTI)

    Boettcher, C.W.; Hamilton, B.H.; Zweig, W.L.

    1980-12-09

    A control arrangement for a three-phase, uninterruptible power supply generates timing signals to drive the static switches of inverters located in each phase. This control arrangement precisely controls the phase differences of the inverter signals with relation to each other so that while the overall three-phase power supplied by the inverters is nulled, power circulation through the inverters compensates for unbalanced output loads thereby maintaining balanced phase angles between the output voltage and a balanced input impedance at the input of the power supply.

  18. Hanford Site guide for preparing and maintaining generator group pollution prevention program documentation

    SciTech Connect (OSTI)

    PLACE, B.G.

    1998-11-16

    This document provides guidance to generator groups for preparing and maintaining documentation of Pollution Prevention Waste Minimization (P2/WMin) Program activities. The guidance is one of a hierarchical series that includes the Hanford Site Waste Minimization and Pollution Prevention Awareness Program Plan (DOE-RL, 1998a) and Prime contractor implementation plans describing programs required by Resource Conservation and Recovery Act of 1976 (RCRA) 3002(b) and 3005(h) (RCRA and EPA, 1994). Documentation guidance for the following five P2/WMin elements are discussed: Fiscal Year (FY) Goals; Budget and Staffing; Waste Minimization (WMin) Assessments (WMAs); Quarterly Pollution Prevention (P2) Reporting WMin Certification.

  19. NEPA and the Clean Air Act: Complementary approaches to maintaining air quality

    SciTech Connect (OSTI)

    Miller, R.L.; McCold, L.N.

    1991-01-01

    The National Environmental Policy Act (NEPA) of 1969 was established to prevent or eliminate damage to the environmental and biosphere from federal actions and stimulate the public health and welfare. An intertwined focus of NEPA has been to create and maintain conditions under which people and nature can exist in productive harmony. Meanwhile, the Clean Air Act (CAA) and amendments are the basis for regulating emission of air pollutants and otherwise maintaining or enhancing air quality to protect public health and welfare throughout the United States. Because the CAA is to comprehensive, a frequently asked question concerns the usefulness of NEPA from an air quality perspective: What can NEPA accomplish for federal actions that is not already accomplished by the CAA This paper contends that NEPA plays an important role in identifying and informing federal decision-makers of potential air quality impacts of federal actions. NEPA encompasses a broader scope and provides an independent analysis of CAA requirements for federal actions. NEPA ensures that spectrum of potential environmental effects is examined, rather than air quality alone. In some cases, NEPA analyses involve evaluating trade-offs of beneficial and adverse effects among different environmental media, such as air emissions vs solid waste. NEPA air quality analyses sometimes encompass potential concerns that are beyond those required for compliance with the CAA. Also, the environmental consequences of alternative actions are assessed to assist federal decision-makers in selecting a preferred alternative. Finally, proposed federal programs are evaluated under NEPA for their potential effects. 8 refs.

  20. Functional Materials

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Functional Materials Researchers in NETL's Functional Materials Development competency work to discover and develop advanced functional materials and component processing technologies to meet technology performance requirements and enable scale-up for proof-of-concept studies. Research includes separations materials and electrochemical and magnetic materials, specifically: Separations Materials Synthesis, purification, and basic characterization of organic substances, including polymers and

  1. The Need for Essential Consumer Protections: Smart metering proposals and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the move to time-based pricing. August 2010 | Department of Energy metering proposals and the move to time-based pricing. August 2010 The Need for Essential Consumer Protections: Smart metering proposals and the move to time-based pricing. August 2010 There is widespread consensus that the U.S. distribution and transmission systems for vital electricity service need to be modernized and upgraded. This modernization has been recently promoted under the rubric of the Smart Grid. The Smart Grid

  2. On the essential spectrum of certain non-commutative oscillators

    SciTech Connect (OSTI)

    Parmeggiani, Alberto Venni, Alberto

    2013-12-15

    We show here that the spectrum of the family of non-commutative harmonic oscillators Q{sub (α,β)}{sup w}(x,D) for α,β∈R{sub +} in the range αβ = 1 is [0, +∞) and is entirely essential spectrum. The previous existing results concern the case αβ > 1 (case in which Q{sub (α,β)}{sup w}(x,D) is globally elliptic with a discrete spectrum whose qualitative properties are being extensively studied), and ours therefore extend the picture to the range of parameters αβ ⩾ 1.

  3. Hanford Site Guide for Preparing and Maintaining Generator Group Pollution Prevention Program Documentation

    SciTech Connect (OSTI)

    PLACE, B.G.

    2001-11-01

    This document provides guidance to generator groups for preparing and maintaining documentation of Pollution Prevention/Waste Minimization (P2/WMin) hogram activities. The guidance is one of a hierarchical series that includes the ''Hanford Site Waste Minimization and Pollution Prevention Awareness Program Plan'' (DOE-RL, 2001) and Prime Contractor implementation plans describing programs required by ''Resource Conservation and Recovery Act of 1976'' (RCRA) 3002(b) and 3005(h) (RCRA and EPA, 1994) and Department of Energy Acquisition Regulations (DEAR) (48 CFR 970.5204-2 and 48 CFR 970.5204-78). Documentation guidance for the following five P2/WMin elements is discussed: (1) Fiscal Year (FY) Goals; (2) Budget and Staffing; (3) Waste Minimization (WMin) Assessments (WMAs); (4) Pollution Prevention (P2) Reporting; and (5) WMin Certification.

  4. Apparatus for maintaining aligment of a shrinking weld joint in an electron-beam welding operation

    DOE Patents [OSTI]

    Trent, J.B.; Murphy, J.L.

    1980-01-03

    The invention is directed to an apparatus for automatically maintaining a shrinking weld joint in alignement with an electron beam during an electron-beam multipass-welding operation. The apparatus utilizes a bias means for continually urging a workpiece-supporting face plate away from a carriage mounted base that rotatably supports the face plate. The extent of displacement of the face plate away from the base in indicative of the shrinkage occuring in the weld joint area. This displacement is measured and is used to move the base on the carriage a distance equal to one-half the displacement for aligning the weld joint with the electron beam during each welding pass.

  5. Hanford Site Guide for Preparing and Maintaining Generator Group Pollution Prevention Program Documentation

    SciTech Connect (OSTI)

    PLACE, B.G.

    2000-11-01

    This document provides guidance to generator groups for preparing and maintaining documentation of Pollution Prevention/Waste Minimization (P2/WMin) Program activities. The guidance is one of a hierarchical series that includes the Hanford Site Waste Minimization and Pollution Prevention Awareness Program Plan (DOE-RL, 2000) and Prime Contractor implementation plans describing programs required by Resource Conservation and Recovery Act of 1976 (RCRA) 3002(b) and 3005(h) (RCRA and EPA, 1994) and Department of Energy Acquisition Regulations (DEAR) (48 CFR 970.5204-2 and 48 CFR 970.5204-78). Documentation guidance for the following five P2/WMin elements is discussed: Fiscal Year (FY) Goals; Budget and Staffing; Pollution Prevention (P2) Reporting; WMin Certification; and Waste Minimization (WMin) Assessments (WMAs).

  6. Apparatus for maintaining alignment of a shrinking weld joint in an electron-beam welding operation

    DOE Patents [OSTI]

    Trent, Jett B.; Murphy, Jimmy L.

    1981-01-01

    The present invention is directed to an apparatus for automatically maintaining a shrinking weld joint in alignment with an electron beam during an electron-beam multipass-welding operation. The apparatus utilizes a biasing device for continually urging a workpiece-supporting face plate away from a carriage mounted base that rotatably supports the face plate. The extent of displacement of the face plate away from the base is indicative of the shrinkage occuring in the weld joint area. This displacement is measured and is used to move the base on the carriage a distance equal to one-half the displacement for aligning the weld joint with the electron beam during each welding pass.

  7. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration

    SciTech Connect (OSTI)

    Simarro, Maria; Gimenez-Cassina, Alfredo; Kedersha, Nancy; Lazaro, Jean-Bernard; Adelmant, Guillaume O.; Marto, Jarrod A.; Rhee, Kirsten; Tisdale, Sarah; Danial, Nika; Benarafa, Charaf; Orduna, Anonio; Anderson, Paul

    2010-10-22

    Research highlights: {yields} Five members of the FAST kinase domain-containing proteins are localized to mitochondria in mammalian cells. {yields} The FASTKD3 interactome includes proteins involved in various aspects of mitochondrial metabolism. {yields} Targeted knockdown of FASTKD3 significantly reduces basal and maximal mitochondrial oxygen consumption. -- Abstract: Fas-activated serine/threonine phosphoprotein (FAST) is the founding member of the FAST kinase domain-containing protein (FASTKD) family that includes FASTKD1-5. FAST is a sensor of mitochondrial stress that modulates protein translation to promote the survival of cells exposed to adverse conditions. Mutations in FASTKD2 have been linked to a mitochondrial encephalomyopathy that is associated with reduced cytochrome c oxidase activity, an essential component of the mitochondrial electron transport chain. We have confirmed the mitochondrial localization of FASTKD2 and shown that all FASTKD family members are found in mitochondria. Although human and mouse FASTKD1-5 genes are expressed ubiquitously, some of them are most abundantly expressed in mitochondria-enriched tissues. We have found that RNA interference-mediated knockdown of FASTKD3 severely blunts basal and stress-induced mitochondrial oxygen consumption without disrupting the assembly of respiratory chain complexes. Tandem affinity purification reveals that FASTKD3 interacts with components of mitochondrial respiratory and translation machineries. Our results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration.

  8. Histone demethylase JMJD5 is essential for embryonic development

    SciTech Connect (OSTI)

    Oh, Sangphil; Janknecht, Ralf

    2012-03-30

    Highlights: Black-Right-Pointing-Pointer Histone demethylase JMJD5 is essential for embryogenesis. Black-Right-Pointing-Pointer Transcription of tumor suppressor p53 is upregulated in JMJD5 knockout embryos. Black-Right-Pointing-Pointer JMJD5 may antagonize p53-dependent growth inhibition and apoptosis. Black-Right-Pointing-Pointer JMJD5 is overexpressed in leukemias and breast cancer. -- Abstract: Histone lysine methylation is pivotal in regulating chromatin structure and thus profoundly affects the transcriptome. JMJD5 (jumonji C domain-containing 5) is a histone demethylase that specifically removes methyl moieties from dimethylated lysine 36 on histone H3 and exerts a pro-proliferative effect on breast cancer cells. Here, we generated JMJD5 knockout mice in order to study the physiological significance of this enzyme. Whereas heterozygous knockout mice displayed no overt phenotype, homozygous JMJD5 knockouts died around day 10 of embryonal development. JMJD5{sup -/-} embryos showed delayed development already at E8.5 and were actively resorbed at E10.5. While strong JMJD5 expression was observed only in the yolk sac at E8.5, JMJD5 was robustly expressed in E10.5 embryos at several sites, including the heart and eye. Lack of JMJD5 resulted in transcriptional upregulation of the tumor suppressor p53. Concurrently, the cell cycle inhibitor p21 and the pro-apoptotic molecule Noxa, both of which are prominent p53 target genes, became strongly upregulated in JMJD5{sup -/-} embryos. Collectively, our data indicate that JMJD5 is essential during embryonal development and a repressor of p53 expression. The latter suggests that JMJD5 has oncogenic activity and accordingly JMJD5 is upregulated in leukemias and breast cancer.

  9. Current practices for maintaining occupational exposures ALARA at low-level waste disposal sites

    SciTech Connect (OSTI)

    Hadlock, D.E.; Herrington, W.N.; Hooker, C.D.; Murphy, D.W.; Gilchrist, R.L.

    1983-12-01

    The United States Nuclear Regulatory Commission contracted with Pacific Northwest Laboratory (PNL) to provide technical assistance in establishing operational guidelines, with respect to radiation control programs and methods of minimizing occupational radiation exposure, at Low-Level Waste (LLW) disposal sites. The PNL, through site visits, evaluated operations at LLW disposal sites to determine the adequacy of current practices in maintaining occupational exposures as low as is reasonably achievable (ALARA). The data sought included the specifics of: ALARA programs, training programs, external exposure control, internal exposure control, respiratory protection, surveillance, radioactive waste management, facilities and equipment, and external dose analysis. The results of the study indicated the following: The Radiation Protection and ALARA programs at the three commercial LLW disposal sites were observed to be adequate in scope and content compared to similar programs at other types of nuclear facilities. However, it should be noted that there were many areas that could be improved upon to help ensure the health and safety of occupationally exposed individuals.

  10. Low-drag electrical-contact arrangement for maintaining continuity between horizontally movable members

    DOE Patents [OSTI]

    Brown, R.J.; Gerth, H.L.; Robinson, S.C.

    1981-01-23

    This invention is a low-drag electrical contact arrangement for establishing continuity between upper and lower spaced members which are subject to relative horizontal movement. In one aspect, the invention comprises an electrical commutating arrangement which includes a horizontally disposed linear electrical commutator. A horizontally movable electrically conductive pedestal is positioned below the commutator and defines a clearance therewith. The pedestal is formed with a cavity confronting the commutator. In the cavity is a bead of electrical conductive liquid, the bead being characterized by an upwardly convex meniscus portion which extends across the clearance and contacts the commutator. The surface tension of the bead is sufficient to maintain the bead intact when the commutator and pedestal are displaced horizontally at speeds from zero to at least twelve inches a minute. This arrangement provides a significant advance in highly precise machining processes, such as diamond-turning, where precision is limited by the drag imposed by conventional commutators of the carbon-brush type.

  11. Low-drag electrical contact arrangement for maintaining continuity between horizontally movable members

    DOE Patents [OSTI]

    Brown, R. Jack; Gerth, Howard L.; Robinson, Samuel C.

    1982-01-01

    This invention is a low-drag electrical contact arrangement for establishing continuity between upper and lower spaced members which are subject to relative horizontal movement. In one aspect, the invention comprises an electrical commutating arrangement which includes a horizontally disposed linear electrical commutator. A horizontally movable electrically conductive pedestal is positioned below the commutator and defines a clearance therewith. The pedestal is formed with a cavity confronting the commutator. In the cavity is a bead of electrical conductive liquid, the bead being characterized by an upwardly convex meniscus portion which extends across the clearance and contacts the commutator. The surface tension of the bead is sufficient to maintain the bead intact when the commutator and pedestal are displaced horizontally at speeds from zero to at least twelve inches a minute. This arrangement provides a significant advance in highly precise machining processes, such as diamond-turning, where precision is limited by the drag imposed by conventional commutators of the carbon-brush type.

  12. Vehicle Technologies Office 2013 Merit Review: A System for Automatically Maintaining Pressure in a Commercial Truck Tire

    Broader source: Energy.gov [DOE]

    A presentation given by PPG during the 2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting on a system for automatically maintaining tire pressure in commercial truck tires.

  13. Quantification of Libby Reservoir Levels Needed to Maintain or Enhance Reservoir Fisheries, 1985 Annual Report.

    SciTech Connect (OSTI)

    Chisholm, Ian

    1985-01-01

    The goal was to quantify seasonal water levels needed to maintain or enhance the reservoir fishery in Libby. This report summarizes data collected from July 1984 through July 1985, and, where appropriate, presents data collected since 1983. The Canada, Rexford, and Tenmile areas of the reservoir are differentially affected by drawdown. Relative changes in water volume and surface area are greatest in the Canada area and smallest in the Tenmile area. Reservoir morphology and hydraulics probably play a major role in fish distribution through their influence on water temperature. Greatest areas of habitat with optimum water temperature for Salmo spp. and kokanee occurred during the spring and fall months. Dissolved oxygen, pH and conductivity levels were not limiting during any sampling period. Habitat enhancement work was largely unsuccessful. Littoral zone vegetation plantings did not survive well, primarily the result of extreme water level fluctuations. Relative abundances of fish species varied seasonally within and between the three areas. Water temperature is thought to be the major influence in fish distribution patterns. Other factors, such as food availability and turbidity, may mitigate its influence. Sampling since 1975 illustrates a continued increase in kokanee numbers and a dramatic decline in redside shiners. Salmo spp., bull trout, and burbot abundances are relatively low while peamouth and coarsescale sucker numbers remain high. A thermal dynamics model and a trophic level components model will be used to quantify the impact of reservoir operation on the reservoir habitat, primary production, secondary production and fish populations. Particulate carbon will be used to track energy flow through trophic levels. A growth-driven population dynamics simulation model that will estimate the impacts of reservoir operation on fish population dynamics is also being considered.

  14. A rationale for maintaining the double containment requirement for plutonium shipments

    SciTech Connect (OSTI)

    Channell, James K.; Anastas, George

    2003-12-31

    Current U.S. Nuclear Regulatory Commission (NRC) transportation regulations (10 CFR 71.63 (b)) require that all shipments containing more than 20 curies of plutonium must be transported in packages that provide double containment. On April 30, 2002 the NRC issued a proposed rule that would eliminate 71.63(b) and the double containment requirement. NRCs reasons for proposing elimination of 71.63(b) are: (1) compatibility with International Atomic Energy Agency Transportation Safety Standards (which do not have the requirement); (2) the current rule is inconsistent with the A1/A2 system since it applies only to plutonium; (3) double containment causes a heavier package and results in higher transportation costs; (4) the separate inner containment results in additional radiation exposure; and (5) while there would be additional protection from a separate inner container in an accident; this type of approach is not risk informed nor performance based. The Environmental Evaluation Group (EEG) has been a proponent of the double containment requirement for the Waste Isolation Pilot Plant (WIPP) shipments for twenty years. This requirement affects shipments to WIPP much more than any other current or planned shipping campaign because reactor fuel elements, metal or metal alloy, and vitrified high-level waste are exempt from 71.63(b). EEG submitted comments on the Proposed Rule on July 26, 2002 (Appendix C). This report is an update and expansion of the July 26, 2002 comments. Actual WIPP experience with shipments in the double contained TRUPACT-II package is used to respond to NRC arguments for deletion of 71.63(b) and offers a rationale for maintaining the current requirement.

  15. Safety Management Functions, Responsibilities, and Authorities

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-05-22

    This Manual provides the responsibilities of Headquarters and field element offices required by DOE P 411.1, Safety Management Functions, Responsibilities and Authorities Policy, dated 1-28-97. It also contains detailed requirements to supplement the policy's direction for each DOE organization having safety management functions to establish and maintain separate documentation of their responsibilities and authorities. Cancels DOE M 411.1-1A. Canceled by DOE M 411.1-1C.

  16. Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice

    SciTech Connect (OSTI)

    Zhang, Pengpeng; Shan, Tizhong; Liang, Xinrong; Deng, Changyan; Kuang, Shihuan

    2014-09-12

    Highlights: mTOR is a critical regulator of many biological processes yet its function in heart is not well understood. MCK-Cre/Mtor{sup flox/flox} mice were established to delete Mtor in cardiomyocytes. The mTOR-mKO mice developed normally but die prematurely within 5 weeks after birth due to heart disease. The mTOR-mKO mice had dilated myocardium and increased cell death. mTOR-mKO hearts had reduced expression of metabolic genes and activation of mTOR target proteins. - Abstract: Mammalian target of rapamycin (mTOR) is a critical regulator of protein synthesis, cell proliferation and energy metabolism. As constitutive knockout of Mtor leads to embryonic lethality, the in vivo function of mTOR in perinatal development and postnatal growth of heart is not well defined. In this study, we established a muscle-specific mTOR conditional knockout mouse model (mTOR-mKO) by crossing MCK-Cre and Mtor{sup flox/flox} mice. Although the mTOR-mKO mice survived embryonic and perinatal development, they exhibited severe postnatal growth retardation, cardiac muscle pathology and premature death. At the cellular level, the cardiac muscle of mTOR-mKO mice had fewer cardiomyocytes due to apoptosis and necrosis, leading to dilated cardiomyopathy. At the molecular level, the cardiac muscle of mTOR-mKO mice expressed lower levels of fatty acid oxidation and glycolysis related genes compared to the WT littermates. In addition, the mTOR-mKO cardiac muscle had reduced Myh6 but elevated Myh7 expression, indicating cardiac muscle degeneration. Furthermore, deletion of Mtor dramatically decreased the phosphorylation of S6 and AKT, two key targets downstream of mTORC1 and mTORC2 mediating the normal function of mTOR. These results demonstrate that mTOR is essential for cardiomyocyte survival and cardiac muscle function.

  17. Definition and means of maintaining the ventilation system confinement portion of the PFP safety envelope

    SciTech Connect (OSTI)

    Dick, J.D.; Grover, G.A.; O`Brien, P.M., Fluor Daniel Hanford

    1997-03-05

    The Plutonium Finishing Plant Heating Ventilation and Cooling system provides for the confinement of radioactive releases to the environment and provides for the confinement of radioactive contamination within designated zones inside the facility. This document identifies the components and procedures necessary to ensure the HVAC system provides these functions. Appendices E through J provide a snapshot of non-safety class HVAC equipment and need not be updated when the remainder of the document and Appendices A through D are updated.

  18. Elementary Functions

    Energy Science and Technology Software Center (OSTI)

    1986-05-01

    The ALTERNATIVE LIBRARY is a library of elementary functions prepared for use with the standard FORTRAN compiler under 4.2 BSD UNIX as an alternative to the standard system library. The library offers improved accuracy as well as additional capabilities. It includes routines ASIN, ACOS, COSH, EXP, LOG, LOG10, POW, SIN, COS, SINH, TAN, and TANH. These alternative routines have slightly modified domains and slightly different responses to invalid arguments. Four routines, not part of themore » standard library, are provided: ADX(X,N), a double-precision function that returns the double-precision argument X scaled by 2 raised to the Nth power; INTXP(X), an integer function that returns as a signed integer the exponent of the double-precision argument X; SETXP(X,N), a double-precision function that returns the double-precision argument X with its exponent replaced by N; and DCOTAN(X), a double-precision function that returns the cotangent of the double-precision argument X, where X is given in radians.« less

  19. Receptor expression is essential for proliferation induced by dimerized Jak kinases

    SciTech Connect (OSTI)

    Fujii, Hodaka

    2008-06-13

    Two members of Jak kinases, Jak1 and Jak3, are associated with the cytoplasmic domains of the interleukin-2 (IL-2) receptor (IL-2R) {beta} chain (IL-2R{beta}) and the common cytokine receptor {gamma} chain ({gamma}c), respectively, and accumulating evidence indicates their functional importance in IL-2 signaling. Here, I showed that coumermycin-induced chemical heterodimerization of Jak1 and Jak3 but not homodimerization of Jak1 or Jak3 induces cell proliferation of an IL-2R-reconstituted cell line. In this regard, expression of IL-2R{beta} was essential for cell proliferation by chemical heterodimerization of Jak1 and Jak3, indicating that dimerized Jak1 and Jak3 induce heterodimerization of IL-2R{beta} and {gamma}c, which may activate receptor-bound signaling molecules. Previous reports using chemical dimerization suggest that dimerization of Jak kinases is sufficient to induce cell proliferation. The present study indicates that re-evaluation of this conclusion is necessary and that interpretation of functional analysis of signaling molecules using chemical dimerizers needs more careful assessment.

  20. Process for functionalizing alkanes

    DOE Patents [OSTI]

    Bergman, Robert G.; Janowicz, Andrew H.; Periana-Pillai, Roy A.

    1985-01-01

    Process for functionalizing saturated hydrocarbons selectively in the terminal position comprising: (a) reacting said saturated hydrocarbons of the formula: RH where: H represents a hydrogen atom, and R represents a saturated hydrocarbon radical, with a metal complex of the formula: CpRhPMe.sub.3 H.sub.2 where: Cp represents a pentamethylated cyclopentadienyl radical, Rh represents a rhodium atom, P represents a phosphorous atom, Me represents a methyl group, H represents a hydrogen atom, in the presence of ultraviolet radiation at a temperature maintained at about -60.degree. to -17.degree. C. to form a hydridoalkyl complex of the formula: CpRhPMe.sub.3 RH (b) reacting said hydridoalkyl complex with a haloform of the formula: CHX.sub.3 where: X represents a bromine, iodine or chlorine atom, at a temperature in the range of about -60.degree. to -17.degree. C. to form the corresponding haloalkyl complex of step (a) having the formula: CpRhPMe.sub.3 RX; and, (c) reacting said haloalkyl complex formed in (b) with halogen (X.sub.2) at a temperature in the range of about -60.degree. to 25.degree. C. (i.e. ambient) to form a functional haloalkyl compound.

  1. Maintaining low exhaust emissions with turbocharged gas engines using a feedback air-fuel ratio control system

    SciTech Connect (OSTI)

    Eckard, D.W.; Serve, J.V.

    1987-10-01

    Maintaining low exhaust emissions on a turbocharged, natural gas engine through the speed and load range requires precise control of the air-fuel ratio. Changes in ambient conditions or fuel heating value will cause the air-fuel ratio to change substantially. By combining air-gas pressure with preturbine temperature control, the air-fuel ratio can be maintained regardless of changes in the ambient conditions or the fuel's heating value. Design conditions and operating results are presented for an air-fuel controller for a turbocharged engine.

  2. Function Sequencer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    mFUSE: Function Sequencer for MATLAB Help Manual LANL/UCSD Engineering Institute LA-CC-10-033 LA-UR 10-01264 c Copyright 2010, Los Alamos National Security, LLC All rights reserved. July 29, 2010 LA-CC-10-033 LA-UR 10-01264 Contents I What is mFUSE? 4 1 Features . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2 Version Numbers . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3 About This Manual . . . . . . . . . . . . . . . . . . . . . . . . 6 4 Author Information . . . . .

  3. Load requirements for maintaining structural integrity of Hanford single-shell tanks during waste feed delivery and retrieval activities

    SciTech Connect (OSTI)

    JULYK, L.J.

    1999-09-22

    This document provides structural load requirements and their basis for maintaining the structural integrity of the Hanford Single-Shell Tanks during waste feed delivery and retrieval activities. The requirements are based on a review of previous requirements and their basis documents as well as load histories with particular emphasis on the proposed lead transfer feed tanks for the privatized vitrification plant.

  4. Trichodesmium genome maintains abundant, widespread noncoding DNA in situ, despite oligotrophic lifestyle

    SciTech Connect (OSTI)

    Walworth, Nathan G.; Pfreundt, Ulrike; Nelson, William C.; Mincer, Tracy; Heidelberg, John F.; Fu, Feixue; Waterbury, John B.; Glavina del Rio, T.; Goodwin, Lynne A.; Kyrpides, Nikos; Land, Miriam L.; Woyke, Tanja; Hutchins, David A.; Hess, Wolfgang R.; Webb, Eric A.

    2015-04-07

    Understanding the evolution of the free-living, cyanobacterial, diazotroph Trichodesmium is of great importance due to its critical role in oceanic biogeochemistry and primary production. Unlike the other >150 available genomes of free-living cyanobacteria, only 63.8% of the Trichodesmium erythraeum (strain IMS101) genome is predicted to encode protein, which is 20-25% less than the average for other cyanobacteria and non-pathogenic, free-living bacteria. We use distinctive isolates and metagenomic data to show that low coding density observed in IMS101 is a common feature of the Trichodesmium genus both in culture and in situ. Transcriptome analysis indicates that 86% of the non-coding space is expressed, although the function of these transcripts is unclear. The density of noncoding, possible regulatory elements predicted in Trichodesmium, when normalized per intergenic kilobase, was comparable and two fold higher than that found in the gene dense genomes of the sympatric cyanobacterial genera Synechococcus and Prochlorococcus, respectively. Conserved Trichodesmium ncRNA secondary structures were predicted between most culture and metagenomic sequences lending support to the structural conservation. Conservation of these intergenic regions in spatiotemporally separated Trichodesmium populations suggests possible genus-wide selection for their maintenance. These large intergenic spacers may have developed during intervals of strong genetic drift caused by periodic blooms of a subset of genotypes, which may have reduced effective population size. Our data suggest that transposition of selfish DNA, low effective population size, and high fidelity replication allowed the unusual inflation of noncoding sequence observed in Trichodesmium despite its oligotrophic lifestyle.

  5. Integrated Project Teams - An Essential Element of Project Management during Project Planning and Execution - 12155

    SciTech Connect (OSTI)

    Burritt, James G.; Berkey, Edgar

    2012-07-01

    Managing complex projects requires a capable, effective project manager to be in place, who is assisted by a team of competent assistants in various relevant disciplines. This team of assistants is known as the Integrated Project Team (IPT). he IPT is composed of a multidisciplinary group of people who are collectively responsible for delivering a defined project outcome and who plan, execute, and implement over the entire life-cycle of a project, which can be a facility being constructed or a system being acquired. An ideal IPT includes empowered representatives from all functional areas involved with a project-such as engineering design, technology, manufacturing, test and evaluation, contracts, legal, logistics, and especially, the customer. Effective IPTs are an essential element of scope, cost, and schedule control for any complex, large construction project, whether funded by DOE or another organization. By recently assessing a number of major, on-going DOE waste management projects, the characteristics of high performing IPTs have been defined as well as the reasons for potential IPT failure. Project managers should use IPTs to plan and execute projects, but the IPTs must be properly constituted and the members capable and empowered. For them to be effective, the project manager must select the right team, and provide them with the training and guidance for them to be effective. IPT members must treat their IPT assignment as a primary duty, not some ancillary function. All team members must have an understanding of the factors associated with successful IPTs, and the reasons that some IPTs fail. Integrated Project Teams should be used by both government and industry. (authors)

  6. A Godunov-like point-centered essentially Lagrangian hydrodynamic approach

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Morgan, Nathaniel R.; Waltz, Jacob I.; Burton, Donald E.; Charest, Marc R.; Canfield, Thomas R.; Wohlbier, John G.

    2014-10-28

    We present an essentially Lagrangian hydrodynamic scheme suitable for modeling complex compressible flows on tetrahedron meshes. The scheme reduces to a purely Lagrangian approach when the flow is linear or if the mesh size is equal to zero; as a result, we use the term essentially Lagrangian for the proposed approach. The motivation for developing a hydrodynamic method for tetrahedron meshes is because tetrahedron meshes have some advantages over other mesh topologies. Notable advantages include reduced complexity in generating conformal meshes, reduced complexity in mesh reconnection, and preserving tetrahedron cells with automatic mesh refinement. A challenge, however, is tetrahedron meshesmore » do not correctly deform with a lower order (i.e. piecewise constant) staggered-grid hydrodynamic scheme (SGH) or with a cell-centered hydrodynamic (CCH) scheme. The SGH and CCH approaches calculate the strain via the tetrahedron, which can cause artificial stiffness on large deformation problems. To resolve the stiffness problem, we adopt the point-centered hydrodynamic approach (PCH) and calculate the evolution of the flow via an integration path around the node. The PCH approach stores the conserved variables (mass, momentum, and total energy) at the node. The evolution equations for momentum and total energy are discretized using an edge-based finite element (FE) approach with linear basis functions. A multidirectional Riemann-like problem is introduced at the center of the tetrahedron to account for discontinuities in the flow such as a shock. Conservation is enforced at each tetrahedron center. The multidimensional Riemann-like problem used here is based on Lagrangian CCH work [8, 19, 37, 38, 44] and recent Lagrangian SGH work [33-35, 39, 45]. In addition, an approximate 1D Riemann problem is solved on each face of the nodal control volume to advect mass, momentum, and total energy. The 1D Riemann problem produces fluxes [18] that remove a volume error in the PCH discretization. A 2-stage Runge–Kutta method is used to evolve the solution in time. The details of the new hydrodynamic scheme are discussed; likewise, results from numerical test problems are presented.« less

  7. A Godunov-like point-centered essentially Lagrangian hydrodynamic approach

    SciTech Connect (OSTI)

    Morgan, Nathaniel R.; Waltz, Jacob I.; Burton, Donald E.; Charest, Marc R.; Canfield, Thomas R.; Wohlbier, John G.

    2014-10-28

    We present an essentially Lagrangian hydrodynamic scheme suitable for modeling complex compressible flows on tetrahedron meshes. The scheme reduces to a purely Lagrangian approach when the flow is linear or if the mesh size is equal to zero; as a result, we use the term essentially Lagrangian for the proposed approach. The motivation for developing a hydrodynamic method for tetrahedron meshes is because tetrahedron meshes have some advantages over other mesh topologies. Notable advantages include reduced complexity in generating conformal meshes, reduced complexity in mesh reconnection, and preserving tetrahedron cells with automatic mesh refinement. A challenge, however, is tetrahedron meshes do not correctly deform with a lower order (i.e. piecewise constant) staggered-grid hydrodynamic scheme (SGH) or with a cell-centered hydrodynamic (CCH) scheme. The SGH and CCH approaches calculate the strain via the tetrahedron, which can cause artificial stiffness on large deformation problems. To resolve the stiffness problem, we adopt the point-centered hydrodynamic approach (PCH) and calculate the evolution of the flow via an integration path around the node. The PCH approach stores the conserved variables (mass, momentum, and total energy) at the node. The evolution equations for momentum and total energy are discretized using an edge-based finite element (FE) approach with linear basis functions. A multidirectional Riemann-like problem is introduced at the center of the tetrahedron to account for discontinuities in the flow such as a shock. Conservation is enforced at each tetrahedron center. The multidimensional Riemann-like problem used here is based on Lagrangian CCH work [8, 19, 37, 38, 44] and recent Lagrangian SGH work [33-35, 39, 45]. In addition, an approximate 1D Riemann problem is solved on each face of the nodal control volume to advect mass, momentum, and total energy. The 1D Riemann problem produces fluxes [18] that remove a volume error in the PCH discretization. A 2-stage RungeKutta method is used to evolve the solution in time. The details of the new hydrodynamic scheme are discussed; likewise, results from numerical test problems are presented.

  8. Emergency Support Function #12; Energy Annex | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Support Function #12; Energy Annex Emergency Support Function #12; Energy Annex Emergency Support Function (ESF) #12 - Energy is intended to facilitate the restoration of damaged energy systems and components when activated by the Secretary of Homeland Security for incidents requiring a coordinated Federal response. Under Department of Energy (DOE) leadership, ESF #12 is an integral part of the larger DOE responsibility of maintaining continuous and reliable energy supplies for the United States

  9. Maintaining the Stockpile

    National Nuclear Security Administration (NNSA)

    %2A en Albuquerque Complex http:nnsa.energy.govaboutusourlocationsnnsa-complex

    Page...

  10. Maintaining the Stockpile

    National Nuclear Security Administration (NNSA)

    stockpilestewardshipdefensesciencedsfacilitieslansce" target"blank">Los Alamos Neutron Science Center (LANSCE), Los Alamos National Laboratory

  11. Apparatus for adjusting and maintaining the humidity of gas at a constant value within a closed system

    DOE Patents [OSTI]

    Abernathy, B.R.; Walters, R.R.

    1985-08-05

    The humidity of a gas within a closed system is maintained at constant level by providing a saturated salt solution within a lower chamber in communication with an upper chamber conjointly defined by upper and lower container sections in sealing contact with each other to establish a closed container. A partition wall separates the salt solution from the test region in the upper chamber. A tube extending through the partition plate allows humidified gas to pass from the lower to the upper chamber. A glass wool plug or membranous material within the tube prevents migration of salt into the test region.

  12. Apparatus for adjusting and maintaining the humidity of gas at a constant value within a closed system

    DOE Patents [OSTI]

    Abernathy, Bethel R.; Walters, Ronald R.

    1986-01-01

    The humidity of a gas within a closed system is maintained at constant level by providing a saturated salt solution within a lower chamber in communication with an upper chamber conjointly defined by upper and lower container sections in sealing contact with each other to establish a closed container. A partition wall separates the salt solution from the test region in the upper chamber. A tube extending through the partition plate allows humidified gas to pass from the lower to the upper chamber. A glass wool plug or membranous material within the tube prevents migration of salt into the test region.

  13. Advanced Inverter Functions to Support High Levels of Distributed Solar: Policy and Regulatory Considerations (Brochure)

    SciTech Connect (OSTI)

    Not Available

    2014-11-01

    This paper explains how advanced inverter functions (sometimes called 'smart inverters') contribute to the integration of high levels of solar PV generation onto the electrical grid and covers the contributions of advanced functions to maintaining grid stability. Policy and regulatory considerations associated with the deployment of advanced inverter functions are also introduced.

  14. The Importance of Establishing and Maintaining Continuity of Knowledge during 21st Century Nuclear Fuel Cycle Activities

    SciTech Connect (OSTI)

    Pickett, Chris A; Rowe, Nathan C; Younkin, James R; Wishard, Bernard; Bean, Robert; Blair, Dianna; Lawson, Ray; Weeks, George; Tolk, Keith

    2012-01-01

    During this century, the entire nuclear fuel cycle will expand and become increasingly more global, taxing both the resources and capabilities of the International Atomic Energy Agency (IAEA) to maintain an effective Continuity of Knowledge (CoK) and its ability to provide timely detection of diversion. Uranium that currently is mined and milled in one country will be converted, enriched, and fabricated into fuel for reactors in an expanding set of new countries. This expansion will make it harder to guarantee that regional activities stay regional and that diversion detection is timely unless new and sustainable tools are developed to improve inspector effectiveness. To deal with this emerging reality, the IAEA must increase its use of unattended monitoring and employ new tools and methods that enhance CoK during all phases of the fuel cycle. This approach will help provide useful information to aid in detecting undeclared activities and create opportunities for timely and appropriate responses to events well before they enter phases of greater concern (e.g., enrichment). The systems that maintain CoK of safeguarded assets rely on containment and surveillance (C/S) technologies. The 21st century fuel cycle will require increased use of these technologies and systems, plus greater implementation of unattended systems that can securely collect data when inspectors are not present.

  15. Vermont Land Use: Essentials of Local Land Use Planning and Regulation...

    Open Energy Info (EERE)

    Use: Essentials of Local Land Use Planning and Regulation Jump to: navigation, search OpenEI Reference LibraryAdd to library PermittingRegulatory Guidance - GuideHandbook:...

  16. A STUDY OF FISCHER 344 RATS EXPOSED TO SILICA DUST AT CONCENTRATIONS OF 0, 2, 10 OR 20 MG/M3, THEN MAINTAINED FOR SIX MONTHS PRIOR TO ASSESSMENT.

    SciTech Connect (OSTI)

    KUTZMAN,R.S.

    1984-11-01

    The major objective of this study was to relate the results of a series of functional tests to the compositional and structural alterations in the rat lung induced by subchronic exposure to silica dust. To induce a fibrotic lesion, Fischer-344 rats were exposed to either 0, 2, 10, or 20 mg Si0{sub 2}/m{sup 3} for 6 hours/day, 5 days/week for six months and then maintained in an animal room, equipped with a laminar flow unit, for six months prior to assessment of the end points.

  17. Essential roles of protein-solvent many-body correlation in solvent-entropy

    Office of Scientific and Technical Information (OSTI)

    effect on protein folding and denaturation: Comparison between hard-sphere solvent and water (Journal Article) | SciTech Connect Essential roles of protein-solvent many-body correlation in solvent-entropy effect on protein folding and denaturation: Comparison between hard-sphere solvent and water Citation Details In-Document Search Title: Essential roles of protein-solvent many-body correlation in solvent-entropy effect on protein folding and denaturation: Comparison between hard-sphere

  18. Twin-tailed fail-over for fileservers maintaining full performance in the presence of a failure

    DOE Patents [OSTI]

    Coteus, Paul W.; Gara, Alan G.; Giampapa, Mark E.; Heidelberger, Philip; Steinmacher-Burow, Burkhard D.

    2008-02-12

    A method for maintaining full performance of a file system in the presence of a failure is provided. The file system having N storage devices, where N is an integer greater than zero and N primary file servers where each file server is operatively connected to a corresponding storage device for accessing files therein. The file system further having a secondary file server operatively connected to at least one of the N storage devices. The method including: switching the connection of one of the N storage devices to the secondary file server upon a failure of one of the N primary file servers; and switching the connections of one or more of the remaining storage devices to a primary file server other than the failed file server as necessary so as to prevent a loss in performance and to provide each storage device with an operating file server.

  19. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Print Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is a process critical to the life and death of a cell. Membrane transport proteins-functioning either as

  20. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Print Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is a process critical to the life and death of a cell. Membrane transport proteins-functioning either as

  1. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Print Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is a process critical to the life and death of a cell. Membrane transport proteins-functioning either as

  2. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Structures for Three Membrane Transport Proteins Yield Functional Insights Print Wednesday, 27 January 2010 00:00 Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is

  3. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures for Three Membrane Transport Proteins Yield Functional Insights Print Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is a process critical to the life and death of a cell. Membrane transport proteins-functioning either as

  4. Maintaining a Technology-Neutral Approach to Hydrogen Production Process Development through Conceptual Design of the Next Generation Nuclear Plant

    SciTech Connect (OSTI)

    Michael W. Patterson

    2008-05-01

    The Next Generation Nuclear Plant (NGNP) project was authorized in the Energy Policy Act of 2005 (EPAct), tasking the U.S. Department of Energy (DOE) with demonstrating High Temperature Gas-Cooled Reactor (HTGR) technology. The demonstration is to include the technical, licensing, operational, and commercial viability of HTGR technology for the production of electricity and hydrogen. The Nuclear Hydrogen Initiative (NHI), a component of the DOE Hydrogen Program managed by the Office of Nuclear Energy, is also investigating multiple approaches to cost effective hydrogen production from nuclear energy. The objective of NHI is development of the technology and information basis for a future decision on commercial viability. The initiatives are clearly intertwined. While the objectives of NGNP and NHI are generally consistent, NGNP has progressed to the project definition phase and the project plan has matured. Multiple process applications for the NGNP require process heat, electricity and hydrogen in varied combinations and sizes. Coupling these processes to the reactor in multiple configurations adds complexity to the design, licensing and demonstration of both the reactor and the hydrogen production process. Commercial viability of hydrogen production may depend on the specific application and heat transport configuration. A component test facility (CTF) is planned by the NGNP to support testing and demonstration of NGNP systems, including those for hydrogen production, in multiple configurations. Engineering-scale demonstrations in the CTF are expected to start in 2012 to support scheduled design and licensing activities leading to subsequent construction and operation. Engineering-scale demonstrations planned by NHI are expected to start at least two years later. Reconciliation of these schedules is recommended to successfully complete both initiatives. Hence, closer and earlier integration of hydrogen process development and heat transport systems is sensible. For integration purposes, an analysis comparing the design, cost and schedule impact of maintaining a technology neutral approach through conceptual design or making an early hydrogen process technology selection was performed. Early selection does not specifically eliminate a technology, but rather selects the first hydrogen technology for demonstration. A systems-engineering approach was taken to define decision-making criteria for selecting a hydrogen technology. The relative technical, cost and schedule risks of each approach were analyzed and risk mitigation strategies were recommended, including provisions to maintain close collaboration with the NHI. The results of these analyses are presented here.

  5. Year 2 Report: Protein Function Prediction Platform

    SciTech Connect (OSTI)

    Zhou, C E

    2012-04-27

    Upon completion of our second year of development in a 3-year development cycle, we have completed a prototype protein structure-function annotation and function prediction system: Protein Function Prediction (PFP) platform (v.0.5). We have met our milestones for Years 1 and 2 and are positioned to continue development in completion of our original statement of work, or a reasonable modification thereof, in service to DTRA Programs involved in diagnostics and medical countermeasures research and development. The PFP platform is a multi-scale computational modeling system for protein structure-function annotation and function prediction. As of this writing, PFP is the only existing fully automated, high-throughput, multi-scale modeling, whole-proteome annotation platform, and represents a significant advance in the field of genome annotation (Fig. 1). PFP modules perform protein functional annotations at the sequence, systems biology, protein structure, and atomistic levels of biological complexity (Fig. 2). Because these approaches provide orthogonal means of characterizing proteins and suggesting protein function, PFP processing maximizes the protein functional information that can currently be gained by computational means. Comprehensive annotation of pathogen genomes is essential for bio-defense applications in pathogen characterization, threat assessment, and medical countermeasure design and development in that it can short-cut the time and effort required to select and characterize protein biomarkers.

  6. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Extracting the Eliashberg Function Print Wednesday, 23 February 2005 00:00 A multitude of important chemical, physical, and biological phenomena...

  7. Integrated in silico analyses of regulatory and metabolic networks of Synechococcus sp. PCC 7002 reveal relationships between gene centrality and essentiality

    SciTech Connect (OSTI)

    Song, Hyun-Seob; McClure, Ryan S.; Bernstein, Hans C.; Overall, Christopher C.; Hill, Eric A.; Beliaev, Alex S.

    2015-03-27

    Cyanobacteria dynamically relay environmental inputs to intracellular adaptations through a coordinated adjustment of photosynthetic efficiency and carbon processing rates. The output of such adaptations is reflected through changes in transcriptional patterns and metabolic flux distributions that ultimately define growth strategy. To address interrelationships between metabolism and regulation, we performed integrative analyses of metabolic and gene co-expression networks in a model cyanobacterium, Synechococcus sp. PCC 7002. Centrality analyses using the gene co-expression network identified a set of key genes, which were defined here as ‘topologically important.’ Parallel in silico gene knock-out simulations, using the genome-scale metabolic network, classified what we termed as ‘functionally important’ genes, deletion of which affected growth or metabolism. A strong positive correlation was observed between topologically and functionally important genes. Functionally important genes exhibited variable levels of topological centrality; however, the majority of topologically central genes were found to be functionally essential for growth. Subsequent functional enrichment analysis revealed that both functionally and topologically important genes in Synechococcus sp. PCC 7002 are predominantly associated with translation and energy metabolism, two cellular processes critical for growth. This research demonstrates how synergistic network-level analyses can be used for reconciliation of metabolic and gene expression data to uncover fundamental biological principles.

  8. Integrated in silico analyses of regulatory and metabolic networks of Synechococcus sp. PCC 7002 reveal relationships between gene centrality and essentiality

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Song, Hyun-Seob; McClure, Ryan S.; Bernstein, Hans C.; Overall, Christopher C.; Hill, Eric A.; Beliaev, Alex S.

    2015-03-27

    Cyanobacteria dynamically relay environmental inputs to intracellular adaptations through a coordinated adjustment of photosynthetic efficiency and carbon processing rates. The output of such adaptations is reflected through changes in transcriptional patterns and metabolic flux distributions that ultimately define growth strategy. To address interrelationships between metabolism and regulation, we performed integrative analyses of metabolic and gene co-expression networks in a model cyanobacterium, Synechococcus sp. PCC 7002. Centrality analyses using the gene co-expression network identified a set of key genes, which were defined here as ‘topologically important.’ Parallel in silico gene knock-out simulations, using the genome-scale metabolic network, classified what we termedmore » as ‘functionally important’ genes, deletion of which affected growth or metabolism. A strong positive correlation was observed between topologically and functionally important genes. Functionally important genes exhibited variable levels of topological centrality; however, the majority of topologically central genes were found to be functionally essential for growth. Subsequent functional enrichment analysis revealed that both functionally and topologically important genes in Synechococcus sp. PCC 7002 are predominantly associated with translation and energy metabolism, two cellular processes critical for growth. This research demonstrates how synergistic network-level analyses can be used for reconciliation of metabolic and gene expression data to uncover fundamental biological principles.« less

  9. Truck Essential Power Systems Efficiency Improvements for Medium-Duty Trucks

    SciTech Connect (OSTI)

    Larry Slone; Jeffery Birkel

    2007-12-31

    With a variety of hybrid vehicles available in the passenger car market, electric technologies and components of that scale are becoming readily available. Commercial vehicle segments have lagged behind passenger car markets, leaving opportunities for component and system development. Escalating fuel prices impact all markets and provide motivation for OEMs, suppliers, customers, and end-users to seek new techniques and technologies to deliver reduced fuel consumption. The research presented here specifically targets the medium-duty (MD), Class 4-7, truck market with technologies aimed at reducing fuel consumption. These technologies could facilitate not only idle, but also parasitic load reductions. The development efforts here build upon the success of the More Electric Truck (MET) demonstration program at Caterpillar Inc. Employing a variety of electric accessories, the MET demonstrated the improvement seen with such technologies on a Class 8 truck. The Truck Essential Power Systems Efficiency Improvements for Medium-Duty Trucks (TEPS) team scaled the concepts and successes of MET to a MD chassis. The team designed an integrated starter/generator (ISG) package and energy storage system (ESS), explored ways to replace belt and gear-driven accessory systems, and developed supervisory control algorithms to direct the usage of the generated electricity and system behavior on the vehicle. All of these systems needed to fit within the footprint of a MD vehicle and be compatible with the existing conventional systems to the largest extent possible. The overall goal of this effort was to demonstrate a reduction in fuel consumption across the drive cycle, including during idle periods, through truck electrification. Furthermore, the team sought to evaluate the benefits of charging the energy storage system during vehicle braking. The vehicle features an array of electric accessories facilitating on-demand, variable actuation. Removal of these accessories from the belt or geartrain of the engine yields efficiency improvements for the engine while freeing those accessories to perform at their individual peak efficiencies to meet instantaneous demand. The net result is a systems approach to fuel usage optimization. Unique control algorithms were specifically developed to capitalize on the flexibility afforded by the TEPS architecture. Moreover, the TEPS truck technology mixture exhibits a means to supplant current accessory power sources such as on-board or trailer-mounted gasoline-powered generators or air compressors. Such functionality further enhances the value of the electric systems beyond the fuel savings alone. To demonstrate the fuel economy improvement wrought via the TEPS components, vehicle fuel economy testing was performed on the nearly stock (baseline) truck and the TEPS truck. Table 1 illustrates the fuel economy gains produced by the TEPS truck electrification. While the fuel economy results shown in Table 1 do reflect specific test conditions, they show that electrification of accessory hardware can yield significant fuel savings. In this case, the savings equated to a 15 percent reduction in fuel consumption during controlled on-road testing. Truck electrification allows engine shutdown during idle conditions as well as independent on-demand actuation of accessory systems. In some cases, independent actuation may even include lack of operation, a feature not always present in mechanically driven components. This combination of attributes allows significant improvements in system efficiency and the fuel economy improvements demonstrated by the TEPS team.

  10. Essential Role in Modern Science William E. Johnston, ESnet Adviser and Senior Scientist

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Evolution of Research and Education Networks and their Essential Role in Modern Science William E. Johnston, ESnet Adviser and Senior Scientist Chin Guok, Evangelos Chaniotakis, Kevin Oberman, Eli Dart, Joe Metzger and Mike O'Conner, Core Engineering, Brian Tierney, Advanced Development, Mike Helm and Dhiva Muruganantham, Federated Trust Steve Cotter, Department Head wej@es.net, this talk is available at www.es.net Energy Sciences Network Lawrence Berkeley National Laboratory Networking for the

  11. Teaming/Subcontracting Essential to Small Business Success Presented by: Tiki Dixon

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Teaming/Subcontracting Essential to Small Business Success Presented by: Tiki Dixon Vice President, Tetra Tech Dating Opportunities with Large Business * Blind date * Caught my eye * Formal introduction Right time, right place 2 Building a Relationship with Large Business * Talking to the right person * Expectations of the relationship * Focusing on core company capabilities * Investing in the relationship Where are we going? 3 Engagement to Each Other * Building on a trusting relationship *

  12. The Evolution of Research and Education Networks and their Essential Role in

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be published in: "Trends in High Performance & Large Scale Computing" Lucio Grandinetti and Gerhard Joubert editors, IOS Press publisher The Evolution of Research and Education Networks and their Essential Role in Modern Science William JOHNSTON, Evangelos CHANIOTAKIS, Eli DART, Chin GUOK, Joe METZGER, Brian TIERNEY ESnet, Lawrence Berkeley National Laboratory † Abstract. ESnet - the Energy Sciences Network - has the mission of enabling the aspects of the US Department of

  13. Functionalized boron nitride nanotubes

    DOE Patents [OSTI]

    Sainsbury, Toby; Ikuno, Takashi; Zettl, Alexander K

    2014-04-22

    A plasma treatment has been used to modify the surface of BNNTs. In one example, the surface of the BNNT has been modified using ammonia plasma to include amine functional groups. Amine functionalization allows BNNTs to be soluble in chloroform, which had not been possible previously. Further functionalization of amine-functionalized BNNTs with thiol-terminated organic molecules has also been demonstrated. Gold nanoparticles have been self-assembled at the surface of both amine- and thiol-functionalized boron nitride Nanotubes (BNNTs) in solution. This approach constitutes a basis for the preparation of highly functionalized BNNTs and for their utilization as nanoscale templates for assembly and integration with other nanoscale materials.

  14. Portable Special Function Routines

    Energy Science and Technology Software Center (OSTI)

    1992-02-27

    SPECFUN is a collection of transportable FORTRAN subroutines and accompanying test drivers to evaluate certain special functions.

  15. Audit Report: IG-0685 | Department of Energy

    Energy Savers [EERE]

    maintained multiple document and tracking systems that performed essentially the same function, and had not adequately planned for the scheduling and disposition of records at its...

  16. Crystal Structure and Functional Analysis Identify Evolutionary Secret of

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SerRS in Vascular Development | Stanford Synchrotron Radiation Lightsource Crystal Structure and Functional Analysis Identify Evolutionary Secret of SerRS in Vascular Development Wednesday, July 31, 2013 Aminoacyl-tRNA synthetases (aaRS) have been essential enzymes for protein synthesis throughout evolution. As the tree of life was ascended, tRNA synthetases added new domains, which are generally dispensable for aminoacylation, in a progressive and accretive manner. The acquisitions were

  17. Stearoyl-CoA desaturase is an essential enzyme for the parasitic protist Trypanosoma brucei

    SciTech Connect (OSTI)

    Alloatti, Andres; Gupta, Shreedhara; Gualdron-Lopez, Melisa; Nguewa, Paul A.; Altabe, Silvia G.; Deumer, Gladys; Wallemacq, Pierre; Michels, Paul A.M.; Uttaro, Antonio D.

    2011-08-26

    Highlights: {yields} Inhibiting {Delta}9 desaturase drastically changes T. brucei's fatty-acid composition. {yields} Isoxyl specifically inhibits the {Delta}9 desaturase causing a growth arrest. {yields} RNA interference of desaturase expression causes a similar effect. {yields} Feeding T. brucei-infected mice with Isoxyl decreases the parasitemia. {yields} 70% of Isoxyl-treated mice survived the trypanosome infection. -- Abstract: Trypanosoma brucei, the etiologic agent of sleeping sickness, is exposed to important changes in nutrients and temperature during its life cycle. To adapt to these changes, the fluidity of its membranes plays a crucial role. This fluidity, mediated by the fatty-acid composition, is regulated by enzymes named desaturases. We have previously shown that the oleoyl desaturase is essential for Trypanosoma cruzi and T. brucei. In this work, we present experimental support for the relevance of stearoyl-CoA desaturase (SCD) for T. brucei's survival, in both its insect or procyclic-form (PCF) and bloodstream-form (BSF) stages. We evaluated this essentiality in two different ways: by generating a SCD knocked-down parasite line using RNA interference, and by chemical inhibition of the enzyme with two compounds, Isoxyl and a thiastearate with the sulfur atom at position 10 (10-TS). The effective concentration for 50% growth inhibition (EC{sub 50}) of PCF was 1.0 {+-} 0.2 {mu}M for Isoxyl and 5 {+-} 2 {mu}M for 10-TS, whereas BSF appeared more susceptible with EC{sub 50} values 0.10 {+-} 0.03 {mu}M (Isoxyl) and 1.0 {+-} 0.6 {mu}M (10-TS). RNA interference showed to be deleterious for both stages of the parasite. In addition, T. brucei-infected mice were fed with Isoxyl, causing a reduction of the parasitemia and an increase of the rodents' survival.

  18. A Library of Basic System Functions

    Energy Science and Technology Software Center (OSTI)

    1995-06-01

    BASELIB is a support library for developing high-level library software. Its design is adaptable to other applications (utility routines, compilers, loaders, large application systems, etc.). BASELIB functions perform commonly-used system and I/O requests available in LTSS operating systems. BASELIB routines are machine-dependent; they are closely tied to the machine and operating system for which they were programmed. However, an attempt was made to maintain compatibility and consistency across machines at the BASELIB calling level tomore » provide a common base for moving large software systems across machines. It allows the programmer to structure higher-level software in a machine- independent fashion. Miscellaneous routines are included to perform character and string manipulation, number conversion, and output-file name generation.« less

  19. A Library of Basic System Functions

    Energy Science and Technology Software Center (OSTI)

    1995-06-01

    BASELIB is a support library for developing high-level library software. Its design is adaptable to other applications (utility routines, compilers, loaders, large application systems, etc.). BASELIB functions perform commonly-used system and I/O requests available in LTSS operating systems. BASELIB routines are machine dependent; they are closely tied to the machine and operating system for which they were programmed. However, an attempt was made to maintain compatibility and consistency across machines at the BASELIB calling levelmore » to provide a common base for moving large software systems across machines. It allows the programmer to structure higher level software in a machine independent fashion. Miscellaneous routines are included to perform character and string manipulation, number conversion, and output-file name generation.« less

  20. Functionalized expanded porphyrins

    DOE Patents [OSTI]

    Sessler, Jonathan L; Pantos, Patricia J

    2013-11-12

    Disclosed are functionalized expanded porphyrins that can be used as spectrometric sensors for high-valent actinide cations. The disclosed functionalized expanded porphyrins have the advantage over unfunctionalized systems in that they can be immobilized via covalent attachment to a solid support comprising an inorganic or organic polymer or other common substrates. Substrates comprising the disclosed functionalized expanded porphyrins are also disclosed. Further, disclosed are methods of making the disclosed compounds (immobilized and free), methods of using them as sensors to detect high valent actinides, devices that comprise the disclosed compounds, and kits.

  1. Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences

    SciTech Connect (OSTI)

    Fox Iii, David N.; Le Trong, Isolde; Rajagopal, Ponni; Brzovic, Peter S.; Stenkamp, Ronald E.; Klevit, Rachel E.

    2008-07-25

    BARD1 is the constitutive nuclear partner to the breast and ovarian cancer specific tumor suppressor BRCA1. Together, they form a heterodimeric complex responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control.

  2. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Extracting the Eliashberg Function Print Wednesday, 23 February 2005 00:00 A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these

  3. Center for Functional Nanomaterials

    ScienceCinema (OSTI)

    BNL

    2009-09-01

    Staff from Brookhaven's new Center for Functional Nanomaterials (CFN) describe how this advanced facility will focus on the development and understanding of nanoscale materials. The CFN provides state-of-the-art capabilities for the fabrication and study of nanoscale materials, with an emphasis on atomic-level tailoring to achieve desired properties and functions. The overarching scientific theme of the CFN is the development and understanding of nanoscale materials that address the Nation's challenges in energy security.

  4. Structure function monitor

    DOE Patents [OSTI]

    McGraw, John T.; Zimmer, Peter C.; Ackermann, Mark R.

    2012-01-24

    Methods and apparatus for a structure function monitor provide for generation of parameters characterizing a refractive medium. In an embodiment, a structure function monitor acquires images of a pupil plane and an image plane and, from these images, retrieves the phase over an aperture, unwraps the retrieved phase, and analyzes the unwrapped retrieved phase. In an embodiment, analysis yields atmospheric parameters measured at spatial scales from zero to the diameter of a telescope used to collect light from a source.

  5. Maintainable substrate carrier for electroplating

    DOE Patents [OSTI]

    Chen, Chen-An; Abas, Emmanuel Chua; Divino, Edmundo Anida; Ermita, Jake Randal G.; Capulong, Jose Francisco S.; Castillo, Arnold Villamor; Ma; Diana Xiaobing

    2012-07-17

    One embodiment relates to a substrate carrier for use in electroplating a plurality of substrates. The carrier includes a non-conductive carrier body on which the substrates are placed and conductive lines embedded within the carrier body. A plurality of conductive clip attachment parts are attached in a permanent manner to the conductive lines embedded within the carrier body. A plurality of contact clips are attached in a removable manner to the clip attachment parts. The contact clips hold the substrates in place and conductively connecting the substrates with the conductive lines. Other embodiments, aspects and features are also disclosed.

  6. Maintaining a competitive geothermal industry

    SciTech Connect (OSTI)

    Zodiaco, V.P.

    1996-04-10

    I come to this geothermal business with over 30 years of experience in the power generation industry. I have earned my spurs (so to speak) in the electric utility, nuclear power, coal and the gas-fired cogeneration power businesses. I have been employed by Oxbow Power for the past seven years and for the past 18 months I have been based in Reno and responsible for the operation, maintenance and management of Oxbow`s domestic power projects which include three geothermal and two gas-fired facilities. The Oxbow Power Group (consisting principally of Oxbow Power Corporation, Oxbow Geothermal Corporation, Oxbow Power of Beowawe, Oxbow Power International and Oxbow Power Services, Inc.) is based in West Palm Beach, Florida, and has regional offices in Reno, Hong Kong and Manila to support on-line geothermal projects in Nevada, other domestic power projects and a geothermal plant under construction in the Philippines. Oxbow Power employs approximately 30 professionals in the development and management of power projects and over 100 supervisors and technicians in the operation and maintenance of power facilities. Current ownership in independent power projects total 340 MW in the United States and 47 MW under construction in the Philippines. Oxbow is currently negotiating additional projects in several Asian and Central American countries.

  7. Structure-Assisted Functional Anchor Implantation in Robust Metal-Organic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Frameworks with Ultralarge Pores | Center for Gas SeparationsRelevant to Clean Energy Technologies | Blandine Jerome Structure-Assisted Functional Anchor Implantation in Robust Metal-Organic Frameworks with Ultralarge Pores Previous Next List Jihye Park , Dawei Feng , and Hong-Cai Zhou, J. Am. Chem. Soc. 137, 1663-1672 (2015) DOI: 10.1021/ja5123528 ja-2014-123528_0006 Abstract: A facile functionalization assisted by the structural attributes of PCN-333 has been studied while maintaining the

  8. Aging assessment of essential HVAC chillers used in nuclear power plants. Phase 1, Volume 1

    SciTech Connect (OSTI)

    Blahnik, D.E.; Klein, R.F.

    1993-09-01

    The Pacific Northwest Laboratory conducted a Phase I aging assessment of chillers used in the essential safety air-conditioning systems of nuclear power plants. Centrifugal chillers in the 75- to 750-ton refrigeration capacity range are the predominant type used. The chillers used, and air-conditioning systems served, vary in design from plant-to-plant. It is crucial to keep chiller internals very clean and to prevent the leakage of water, air, and other contaminants into the refrigerant containment system. Periodic operation on a weekly or monthly basis is necessary to remove moisture and noncondensable gases that gradually build up inside the chiller. This is especially desirable if a chiller is required to operate only as an emergency standby unit. The primary stressors and aging mechanisms that affect chillers include vibration, excessive temperatures and pressures, thermal cycling, chemical attack, and poor quality cooling water. Aging is accelerated by moisture, non-condensable gases (e.g., air), dirt, and other contamination within the refrigerant containment system, excessive start/stop cycling, and operating below the rated capacity. Aging is also accelerated by corrosion and fouling of the condenser and evaporator tubes. The principal cause of chiller failures is lack of adequate monitoring. Lack of performing scheduled maintenance and human errors also contribute to failures.

  9. Two Translation Products of Yersinia yscQ Assemble To Form a Complex Essential to Type III Secretion

    SciTech Connect (OSTI)

    Bzymek, Krzysztof P.; Hamaoka, Brent Y.; Ghosh, Partho

    2012-07-11

    The bacterial flagellar C-ring is composed of two essential proteins, FliM and FliN. The smaller protein, FliN, is similar to the C-terminus of the larger protein, FliM, both being composed of SpoA domains. While bacterial type III secretion (T3S) systems encode many proteins in common with the flagellum, they mostly have a single protein in place of FliM and FliN. This protein resembles FliM at its N-terminus and is as large as FliM but is more like FliN at its C-terminal SpoA domain. We have discovered that a FliN-sized cognate indeed exists in the Yersinia T3S system to accompany the FliM-sized cognate. The FliN-sized cognate, YscQ-C, is the product of an internal translation initiation site within the locus encoding the FliM-sized cognate YscQ. Both intact YscQ and YscQ-C were found to be required for T3S, indicating that the internal translation initiation site, which is conserved in some but not all YscQ orthologs, is crucial for function. The crystal structure of YscQ-C revealed a SpoA domain that forms a highly intertwined, domain-swapped homodimer, similar to those observed in FliN and the YscQ ortholog HrcQ{sub B}. A single YscQ-C homodimer associated reversibly with a single molecule of intact YscQ, indicating conformational differences between the SpoA domains of intact YscQ and YscQ-C. A 'snap-back' mechanism suggested by the structure can account for this. The 1:2 YscQ-YscQ-C complex is a close mimic of the 1:4 FliM-FliN complex and the likely building block of the putative Yersinia T3S system C-ring.

  10. Algal functional annotation tool

    SciTech Connect (OSTI)

    Lopez, D.; Casero, D.; Cokus, S. J.; Merchant, S. S.; Pellegrini, M.

    2012-07-01

    The Algal Functional Annotation Tool is a web-based comprehensive analysis suite integrating annotation data from several pathway, ontology, and protein family databases. The current version provides annotation for the model alga Chlamydomonas reinhardtii, and in the future will include additional genomes. The site allows users to interpret large gene lists by identifying associated functional terms, and their enrichment. Additionally, expression data for several experimental conditions were compiled and analyzed to provide an expression-based enrichment search. A tool to search for functionally-related genes based on gene expression across these conditions is also provided. Other features include dynamic visualization of genes on KEGG pathway maps and batch gene identifier conversion.

  11. Adaptive multiconfigurational wave functions

    SciTech Connect (OSTI)

    Evangelista, Francesco A.

    2014-03-28

    A method is suggested to build simple multiconfigurational wave functions specified uniquely by an energy cutoff ?. These are constructed from a model space containing determinants with energy relative to that of the most stable determinant no greater than ?. The resulting ?-CI wave function is adaptive, being able to represent both single-reference and multireference electronic states. We also consider a more compact wave function parameterization (?+SD-CI), which is based on a small ?-CI reference and adds a selection of all the singly and doubly excited determinants generated from it. We report two heuristic algorithms to build ?-CI wave functions. The first is based on an approximate prescreening of the full configuration interaction space, while the second performs a breadth-first search coupled with pruning. The ?-CI and ?+SD-CI approaches are used to compute the dissociation curve of N{sub 2} and the potential energy curves for the first three singlet states of C{sub 2}. Special attention is paid to the issue of energy discontinuities caused by changes in the size of the ?-CI wave function along the potential energy curve. This problem is shown to be solvable by smoothing the matrix elements of the Hamiltonian. Our last example, involving the Cu{sub 2}O{sub 2}{sup 2+} core, illustrates an alternative use of the ?-CI method: as a tool to both estimate the multireference character of a wave function and to create a compact model space to be used in subsequent high-level multireference coupled cluster computations.

  12. GADRAS Detector Response Function.

    SciTech Connect (OSTI)

    Mitchell, Dean J.; Harding, Lee; Thoreson, Gregory G; Horne, Steven M.

    2014-11-01

    The Gamma Detector Response and Analysis Software (GADRAS) applies a Detector Response Function (DRF) to compute the output of gamma-ray and neutron detectors when they are exposed to radiation sources. The DRF is fundamental to the ability to perform forward calculations (i.e., computation of the response of a detector to a known source), as well as the ability to analyze spectra to deduce the types and quantities of radioactive material to which the detectors are exposed. This document describes how gamma-ray spectra are computed and the significance of response function parameters that define characteristics of particular detectors.

  13. Algal functional annotation tool

    Energy Science and Technology Software Center (OSTI)

    2012-07-12

    Abstract BACKGROUND: Progress in genome sequencing is proceeding at an exponential pace, and several new algal genomes are becoming available every year. One of the challenges facing the community is the association of protein sequences encoded in the genomes with biological function. While most genome assembly projects generate annotations for predicted protein sequences, they are usually limited and integrate functional terms from a limited number of databases. Another challenge is the use of annotations tomore » interpret large lists of 'interesting' genes generated by genome-scale datasets. Previously, these gene lists had to be analyzed across several independent biological databases, often on a gene-by-gene basis. In contrast, several annotation databases, such as DAVID, integrate data from multiple functional databases and reveal underlying biological themes of large gene lists. While several such databases have been constructed for animals, none is currently available for the study of algae. Due to renewed interest in algae as potential sources of biofuels and the emergence of multiple algal genome sequences, a significant need has arisen for such a database to process the growing compendiums of algal genomic data. DESCRIPTION: The Algal Functional Annotation Tool is a web-based comprehensive analysis suite integrating annotation data from several pathway, ontology, and protein family databases. The current version provides annotation for the model alga Chlamydomonas reinhardtii, and in the future will include additional genomes. The site allows users to interpret large gene lists by identifying associated functional terms, and their enrichment. Additionally, expression data for several experimental conditions were compiled and analyzed to provide an expression-based enrichment search. A tool to search for functionally-related genes based on gene expression across these conditions is also provided. Other features include dynamic visualization of genes on KEGG pathway maps and batch gene identifier conversion. CONCLUSIONS: The Algal Functional Annotation Tool aims to provide an integrated data-mining environment for algal genomics by combining data from multiple annotation databases into a centralized tool. This site is designed to expedite the process of functional annotation and the interpretation of gene lists, such as those derived from high-throughput RNA-seq experiments. The tool is publicly available at http://pathways.mcdb.ucla.edu.« less

  14. Algal functional annotation tool

    SciTech Connect (OSTI)

    2012-07-12

    Abstract BACKGROUND: Progress in genome sequencing is proceeding at an exponential pace, and several new algal genomes are becoming available every year. One of the challenges facing the community is the association of protein sequences encoded in the genomes with biological function. While most genome assembly projects generate annotations for predicted protein sequences, they are usually limited and integrate functional terms from a limited number of databases. Another challenge is the use of annotations to interpret large lists of 'interesting' genes generated by genome-scale datasets. Previously, these gene lists had to be analyzed across several independent biological databases, often on a gene-by-gene basis. In contrast, several annotation databases, such as DAVID, integrate data from multiple functional databases and reveal underlying biological themes of large gene lists. While several such databases have been constructed for animals, none is currently available for the study of algae. Due to renewed interest in algae as potential sources of biofuels and the emergence of multiple algal genome sequences, a significant need has arisen for such a database to process the growing compendiums of algal genomic data. DESCRIPTION: The Algal Functional Annotation Tool is a web-based comprehensive analysis suite integrating annotation data from several pathway, ontology, and protein family databases. The current version provides annotation for the model alga Chlamydomonas reinhardtii, and in the future will include additional genomes. The site allows users to interpret large gene lists by identifying associated functional terms, and their enrichment. Additionally, expression data for several experimental conditions were compiled and analyzed to provide an expression-based enrichment search. A tool to search for functionally-related genes based on gene expression across these conditions is also provided. Other features include dynamic visualization of genes on KEGG pathway maps and batch gene identifier conversion. CONCLUSIONS: The Algal Functional Annotation Tool aims to provide an integrated data-mining environment for algal genomics by combining data from multiple annotation databases into a centralized tool. This site is designed to expedite the process of functional annotation and the interpretation of gene lists, such as those derived from high-throughput RNA-seq experiments. The tool is publicly available at http://pathways.mcdb.ucla.edu.

  15. Aging assessment of essential HVAC chillers used in nuclear power plants

    SciTech Connect (OSTI)

    Blahnik, D.E.; Camp, T.W.

    1996-09-01

    The Pacific Northwest Laboratory conducted a comprehensive aging assessment of chillers used in the essential safety air-conditioning systems in nuclear power plants (NPPs). The chillers used, and air-conditioning systems served, vary in design from plant to plant. The review of operating experience indicated that chillers experience aging degradation and failures. The primary aging factors of concern for chillers include vibration, excessive temperatures and pressures, thermal cycling, chemical attack, and poor quality cooling water. The evaluation of Licensee Event Reports (LERs) indicated that about 38% of the failures were primarily related to aging, 55% were partially aging related, and 7% of the failures were unassignable. About 25% of the failures were primarily caused by human, design, procedure, and other errors. The large number of errors is probably directly related to the complexity of chillers and their interfacing systems. Nearly all of the LERs were the result of entering plant Technical Specification Limiting Condition for Operation (LCO) that initiated remedial actions like plant shutdown procedures. The trend for chiller-related LERs has stabilized at about 0.13 LERs per plant year since 1988. Carefully following the vendor procedures and monitoring the equipment can help to minimize and/or eliminate most of the premature failures. Recording equipment performance can be useful for trending analysis. Periodic operation for a few hours on a weekly or monthly basis is useful to remove moisture and non-condensable gases that gradually build up inside the chiller. Chiller pressurization kits are available that will help minimize the amount of moisture and air ingress to low-pressure chillers during standby periods. The assessment of service life condition monitoring of chillers indicated there are many simple to sophisticated methods available that can help in chiller surveillance and monitoring.

  16. Process for functionalizing alkanes

    DOE Patents [OSTI]

    Bergman, R.G.; Janowicz, A.H.; Periana, R.A.

    1988-05-24

    Process for functionalizing saturated hydrocarbons comprises: (a) reacting said saturated hydrocarbons of the formula: R[sub 1]H wherein H represents a hydrogen atom; and R[sub 1] represents a saturated hydrocarbon radical, with a metal complex of the formula: CpRh[P(R[sub 2])[sub 3

  17. Repetition frequency scaling of an all-polarization maintaining erbium-doped mode-locked fiber laser based on carbon nanotubes saturable absorber

    SciTech Connect (OSTI)

    Sotor, J. Sobon, G.; Abramski, K. M.; Jagiello, J.; Lipinska, L.

    2015-04-07

    We demonstrate an all-polarization maintaining (PM), mode-locked erbium (Er)-doped fiber laser based on a carbon nanotubes (CNT) saturable absorber (SA). The laser resonator was maximally simplified by using only one passive hybrid component and a pair of fiber connectors with deposited CNTs. The repetition frequency (F{sub rep}) of such a cost-effective and self-starting mode-locked laser was scaled from 54.3 MHz to 358.6 MHz. The highest F{sub rep} was obtained when the total cavity length was shortened to 57 cm. The laser allows ultrashort pulse generation with the duration ranging from 240 fs to 550 fs. Because the laser components were based on PM fibers the laser was immune to the external perturbations and generated laniary polarized light with the degree of polarization (DOP) of 98.7%.

  18. Resizing the conformal window: A {beta}-function ansatz

    SciTech Connect (OSTI)

    Antipin, O.; Tuominen, K.

    2010-04-01

    We propose an ansatz for the nonperturbative beta-function of a generic nonsupersymmetric Yang-Mills theory with or without fermions in an arbitrary representation of the gauge group. While our construction is similar to the recently proposed Ryttov-Sannino all-order beta-function, the essential difference is that it allows for the existence of an unstable ultraviolet fixed point in addition to the predicted Banks-Zaks-like infrared stable fixed point. Our beta-function preserves all of the tested features with respect to the nonsupersymmetric Yang-Mills theories. We predict the conformal window identifying the lower end of it as a merger of the infrared and ultraviolet fixed points.

  19. Process for functionalizing alkanes

    DOE Patents [OSTI]

    Bergman, R.G.; Janowicz, A.H.; Periana-Pillai, R.A.

    1984-06-12

    Process for functionalizing saturated hydrocarbons selectively in the terminal position comprises: (a) reacting said saturated hydrocarbons with a metal complex CpRhPMe/sub 3/H/sub 2/ in the presence of ultraviolet radiation at -60/sup 0/ to -17/sup 0/C to form a hydridoalkyl complex CpRhPMe/sub 3/RH; (b) reacting said hydridoalkyl complex with a haloform CHX/sub 3/ at -60/sup 0/ to -17/sup 0/C to form the corresponding haloalkyl complex of step (a) CpRhPMe/sub 3/RX; and (c) reacting said haloalkyl complex with halogen -60 to 25/sup 0/C to form a functional haloalkyl compound.

  20. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  1. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  2. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  3. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  4. Extracting the Eliashberg Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Extracting the Eliashberg Function Print A multitude of important chemical, physical, and biological phenomena are driven by violations of the Born-Oppenheimer approximation (BOA), which decouples electronic from nuclear motion in quantum calculations of solids. Recent advances in experimental techniques combined with ever-growing theoretical capabilities now hold the promise of presenting an unprecedented picture of these violations. By means of high-resolution angle-resolved photoemission at

  5. Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Burstein, David; Sun, Christine L.; Brown, Christopher T.; Sharon, Itai; Anantharaman, Karthik; Probst, Alexander J.; Thomas, Brian C.; Banfield, Jillian F.

    2016-02-03

    Here, current understanding of microorganism–virus interactions, which shape the evolution and functioning of Earth’s ecosystems, is based primarily on cultivated organisms. Here we investigate thousands of viral and microbial genomes recovered using a cultivation independent approach to study the frequency, variety and taxonomic distribution of viral defence mechanisms. CRISPR-Cas systems that confer microorganisms with immunity to viruses are present in only 10% of 1,724 sampled microorganisms, compared with previous reports of 40% occurrence in bacteria and 81% in archaea. We attribute this large difference to the lack of CRISPR-Cas systems across major bacterial lineages that have no cultivated representatives. Wemore » correlate absence of CRISPR-Cas with lack of nucleotide biosynthesis capacity and a symbiotic lifestyle. Restriction systems are well represented in these lineages and might provide both non-specific viral defence and access to nucleotides.« less

  6. Process for functionalizing alkanes

    DOE Patents [OSTI]

    Bergman, Robert G.; Janowicz, Andrew H.; Periana, Roy A.

    1988-01-01

    Process for functionalizing saturated hydrocarbons comprising: (a) reacting said saturated hydrocarbons of the formula: R.sub.1 H wherein H represents a hydrogen atom; and R.sub.1 represents a saturated hydrocarbon radical, with a metal complex of the formula: CpRh[P(R.sub.2).sub.3 ]H.sub.2 wherein Cp represents a cyclopentadienyl or alkylcyclopentadienyl radical; Rh represents a rhodium atom; P represents a phosphorus atom; R.sub.2 represents a hydrocarbon radical; H represents a hydrogen atom, in the presence of ultraviolet radiation to form a hydridoalkyl complex of the formula: CpRh[P(R.sub.2).sub.3 ](R.sub.1)H (b) reacting said hydridoalkyl complex with an organic halogenating agent such as a tetrahalomethane or a haloform of the formulas: CX'X''X'''X'''' or CHX'X''X''' wherein X', X'', X'", X"" represent halogens selected from bromine, iodine or chlorine atom, at a temperature in the range of about -60.degree. to -17.degree. C. to form the corresponding haloalkyl complex of step (a) having the formula: CpRhPMe.sub.3 RX; and, (c) reacting said haloalkyl complex formed in (b) with halogen (X.sub.2) at a temperature in the range of about -60.degree. to 25.degree. C. (i.e., ambient) to form a functional haloalkyl compound.

  7. Next Generation Nuclear Plant Resilient Control System Functional Analysis

    SciTech Connect (OSTI)

    Lynne M. Stevens

    2010-07-01

    Control Systems and their associated instrumentation must meet reliability, availability, maintainability, and resiliency criteria in order for high temperature gas-cooled reactors (HTGRs) to be economically competitive. Research, perhaps requiring several years, may be needed to develop control systems to support plant availability and resiliency. This report functionally analyzes the gaps between traditional and resilient control systems as applicable to HTGRs, which includes the Next Generation Nuclear Plant; defines resilient controls; assesses the current state of both traditional and resilient control systems; and documents the functional gaps existing between these two controls approaches as applicable to HTGRs. This report supports the development of an overall strategy for applying resilient controls to HTGRs by showing that control systems with adequate levels of resilience perform at higher levels, respond more quickly to disturbances, increase operational efficiency, and increase public protection.

  8. Adapting ORAP to wind plants : industry value and functional requirements.

    SciTech Connect (OSTI)

    Not Available

    2010-08-01

    Strategic Power Systems (SPS) was contracted by Sandia National Laboratories to assess the feasibility of adapting their ORAP (Operational Reliability Analysis Program) tool for deployment to the wind industry. ORAP for Wind is proposed for use as the primary data source for the CREW (Continuous Reliability Enhancement for Wind) database which will be maintained by Sandia to enable reliability analysis of US wind fleet operations. The report primarily addresses the functional requirements of the wind-based system. The SPS ORAP reliability monitoring system has been used successfully for over twenty years to collect RAM (Reliability, Availability, Maintainability) and operations data for benchmarking and analysis of gas and steam turbine performance. This report documents the requirements to adapt the ORAP system for the wind industry. It specifies which existing ORAP design features should be retained, as well as key new requirements for wind. The latter includes alignment with existing and emerging wind industry standards (IEEE 762, ISO 3977 and IEC 61400). There is also a comprehensive list of thirty critical-to-quality (CTQ) functional requirements which must be considered and addressed to establish the optimum design for wind.

  9. Policy Flash 2013-40 Acquisition Guide Chapter 43.3 Maintaining Alignment of Project Management with Contract Management of Non-Management and Operating (M&O) Cost Reimburstment Contracts

    Broader source: Energy.gov [DOE]

    Attached is Policy Flash 2013-40 Acquisition Guide Chapter 43.3 Maintaining Alignment of Project Management with Contract Management of Non-Management and Operating (M&O) Cost Reimbursement...

  10. The N-terminal leucine-zipper motif in PTRF/cavin-1 is essential and sufficient for its caveolae-association

    SciTech Connect (OSTI)

    Wei, Zhuang; Zou, Xinle; Wang, Hongzhong; Lei, Jigang; Wu, Yuan; Liao, Kan

    2015-01-16

    Highlight: • The N-terminal leucine-zipper motif in PTRF/cavin-1 determines caveolar association. • Different cellular localization of PTRF/cavin-1 influences its serine 389 and 391 phosphorylation state. • PTRF/cavin-1 regulates cell motility via its caveolar association. - Abstract: PTRF/cavin-1 is a protein of two lives. Its reported functions in ribosomal RNA synthesis and in caveolae formation happen in two different cellular locations: nucleus vs. plasma membrane. Here, we identified that the N-terminal leucine-zipper motif in PTRF/cavin-1 was essential for the protein to be associated with caveolae in plasma membrane. It could counteract the effect of nuclear localization sequence in the molecule (AA 235–251). Deletion of this leucine-zipper motif from PTRF/cavin-1 caused the mutant to be exclusively localized in nuclei. The fusion of this leucine-zipper motif with histone 2A, which is a nuclear protein, could induce the fusion protein to be exported from nucleus. Cell migration was greatly inhibited in PTRF/cavin-1{sup −/−} mouse embryonic fibroblasts (MEFs). The inhibited cell motility could only be rescued by exogenous cavin-1 but not the leucine-zipper motif deleted cavin-1 mutant. Plasma membrane dynamics is an important factor in cell motility control. Our results suggested that the membrane dynamics in cell migration is affected by caveolae associated PTRF/cavin-1.

  11. Process management using component thermal-hydraulic function classes

    DOE Patents [OSTI]

    Morman, J.A.; Wei, T.Y.C.; Reifman, J.

    1999-07-27

    A process management expert system where following malfunctioning of a component, such as a pump, for determining system realignment procedures such as for by-passing the malfunctioning component with on-line speeds to maintain operation of the process at full or partial capacity or to provide safe shut down of the system while isolating the malfunctioning component. The expert system uses thermal-hydraulic function classes at the component level for analyzing unanticipated as well as anticipated component malfunctions to provide recommended sequences of operator actions. Each component is classified according to its thermal-hydraulic function, and the generic and component-specific characteristics for that function. Using the diagnosis of the malfunctioning component and its thermal hydraulic class, the expert system analysis is carried out using generic thermal-hydraulic first principles. One aspect of the invention employs a qualitative physics-based forward search directed primarily downstream from the malfunctioning component in combination with a subsequent backward search directed primarily upstream from the serviced component. Generic classes of components are defined in the knowledge base according to the three thermal-hydraulic functions of mass, momentum and energy transfer and are used to determine possible realignment of component configurations in response to thermal-hydraulic function imbalance caused by the malfunctioning component. Each realignment to a new configuration produces the accompanying sequence of recommended operator actions. All possible new configurations are examined and a prioritized list of acceptable solutions is produced. 5 figs.

  12. Process management using component thermal-hydraulic function classes

    DOE Patents [OSTI]

    Morman, James A.; Wei, Thomas Y. C.; Reifman, Jaques

    1999-01-01

    A process management expert system where following malfunctioning of a component, such as a pump, for determining system realignment procedures such as for by-passing the malfunctioning component with on-line speeds to maintain operation of the process at full or partial capacity or to provide safe shut down of the system while isolating the malfunctioning component. The expert system uses thermal-hydraulic function classes at the component level for analyzing unanticipated as well as anticipated component malfunctions to provide recommended sequences of operator actions. Each component is classified according to its thermal-hydraulic function, and the generic and component-specific characteristics for that function. Using the diagnosis of the malfunctioning component and its thermal hydraulic class, the expert system analysis is carried out using generic thermal-hydraulic first principles. One aspect of the invention employs a qualitative physics-based forward search directed primarily downstream from the malfunctioning component in combination with a subsequent backward search directed primarily upstream from the serviced component. Generic classes of components are defined in the knowledge base according to the three thermal-hydraulic functions of mass, momentum and energy transfer and are used to determine possible realignment of component configurations in response to thermal-hydraulic function imbalance caused by the malfunctioning component. Each realignment to a new configuration produces the accompanying sequence of recommended operator actions. All possible new configurations are examined and a prioritized list of acceptable solutions is produced.

  13. Functional Accountability | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Functional Accountability Functional Accountability The Office of the Chief Human Capital Officer exercises functional accountability over human resources authorities and human capital programs. This ensures the Department's compliance with regulatory requirements to measure and assess human capital management systems for mission alignment, effectiveness, efficiency, and compliance with merit system principles, laws, and regulations. Documents Available for Download Guidance Memorandum #25

  14. Structure-Assisted Functional Anchor Implantation in Robust Metal-Organic Frameworks with Ultra large Pores

    SciTech Connect (OSTI)

    Park, J; Feng, DW; Zhou, HC

    2015-02-04

    A facile functionalization assisted by the structural attributes of PCN-333 has been studied while maintaining the integrity of the parent MOF including ultralarge pores, chemical robustness, and crystallinity. Herein we thoroughly analyzed ligand exchange phenomena in PCN-333 and demonstrate that the extent of exchange can be tailored by varying the exchange conditions as potential applications may require. Through this method a variety of functional groups are incorporated into PCN-333. To further show the capabilities of this system introduction of a BODIPY fluorophore as a secondary functionality was performed to the functionalized framework via a click reaction. We anticipate the PCN-333 with functional anchor can serve as a stable platform for further chemistry to be explored in future applications

  15. Computing Legacy Software Behavior to Understand Functionality and Security Properties: An IBM/370 Demonstration

    SciTech Connect (OSTI)

    Linger, Richard C; Pleszkoch, Mark G; Prowell, Stacy J; Sayre, Kirk D; Ankrum, Scott

    2013-01-01

    Organizations maintaining mainframe legacy software can benefit from code modernization and incorporation of security capabilities to address the current threat environment. Oak Ridge National Laboratory is developing the Hyperion system to compute the behavior of software as a means to gain understanding of software functionality and security properties. Computation of functionality is critical to revealing security attributes, which are in fact specialized functional behaviors of software. Oak Ridge is collaborating with MITRE Corporation to conduct a demonstration project to compute behavior of legacy IBM Assembly Language code for a federal agency. The ultimate goal is to understand functionality and security vulnerabilities as a basis for code modernization. This paper reports on the first phase, to define functional semantics for IBM Assembly instructions and conduct behavior computation experiments.

  16. FFTF Plant transition function analysis report

    SciTech Connect (OSTI)

    Lund, D.P.; FFTF Working Group

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and function hierarchy charts that describe what needs to be performed to deactivate FFTF.

  17. Methods of making functionalized nanorods

    DOE Patents [OSTI]

    Gur, Ilan; Milliron, Delia; Alivisatos, A. Paul; Liu, Haitao

    2012-01-10

    A process for forming functionalized nanorods. The process includes providing a substrate, modifying the substrate by depositing a self-assembled monolayer of a bi-functional molecule on the substrate, wherein the monolayer is chosen such that one side of the bi-functional molecule binds to the substrate surface and the other side shows an independent affinity for binding to a nanocrystal surface, so as to form a modified substrate. The process further includes contacting the modified substrate with a solution containing nanocrystal colloids, forming a bound monolayer of nanocrystals on the substrate surface, depositing a polymer layer over the monolayer of nanocrystals to partially cover the monolayer of nanocrystals, so as to leave a layer of exposed nanocrystals, functionalizing the exposed nanocrystals, to form functionalized nanocrystals, and then releasing the functionalized nanocrystals from the substrate.

  18. Multi-functional composite structures

    DOE Patents [OSTI]

    Mulligan, Anthony C.; Halloran, John; Popovich, Dragan; Rigali, Mark J.; Sutaria, Manish P.; Vaidyanathan, K. Ranji; Fulcher, Michael L.; Knittel, Kenneth L.

    2004-10-19

    Fibrous monolith processing techniques to fabricate multifunctional structures capable of performing more than one discrete function such as structures capable of bearing structural loads and mechanical stresses in service and also capable of performing at least one additional non-structural function.

  19. Multi-functional composite structures

    DOE Patents [OSTI]

    Mulligan, Anthony C.; Halloran, John; Popovich, Dragan; Rigali, Mark J.; Sutaria, Manish P.; Vaidyanathan, K. Ranji; Fulcher, Michael L.; Knittel, Kenneth L.

    2010-04-27

    Fibrous monolith processing techniques to fabricate multifunctional structures capable of performing more than one discrete function such as structures capable of bearing structural loads and mechanical stresses in service and also capable of performing at least one additional non-structural function.

  20. The Structural Basis for Tight Control of PP2A Methylation and Function by

    Office of Scientific and Technical Information (OSTI)

    LCMT-1 (Journal Article) | SciTech Connect The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1 Citation Details In-Document Search Title: The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1 Proper formation of protein phosphatase 2A (PP2A) holoenzymes is essential for the fitness of all eukaryotic cells. Carboxyl methylation of the PP2A catalytic subunit plays a critical role in regulating holoenzyme assembly; methylation is

  1. High-Level Functional and Operational Requirements for the Advanced Fuel Cycle Facilty

    SciTech Connect (OSTI)

    Charles Park

    2006-12-01

    High-Level Functional & Operational Requirements for the AFCF -This document describes the principal functional and operational requirements for the proposed Advanced Fuel Cycle Facility (AFCF). The AFCF is intended to be the world's foremost facility for nuclear fuel cycle research, technology development, and demonstration. The facility will also support the near-term mission to develop and demonstrate technology in support of fuel cycle needs identified by industry, and the long-term mission to retain and retain U.S. leadership in fuel cycle operations. The AFCF is essential to demonstrate a more proliferation-resistant fuel cycle and make long-term improvements in fuel cycle effectiveness, performance and economy.

  2. Functionalized magnetic nanoparticle analyte sensor

    DOE Patents [OSTI]

    Yantasee, Wassana; Warner, Maryin G; Warner, Cynthia L; Addleman, Raymond S; Fryxell, Glen E; Timchalk, Charles; Toloczko, Mychailo B

    2014-03-25

    A method and system for simply and efficiently determining quantities of a preselected material in a particular solution by the placement of at least one superparamagnetic nanoparticle having a specified functionalized organic material connected thereto into a particular sample solution, wherein preselected analytes attach to the functionalized organic groups, these superparamagnetic nanoparticles are then collected at a collection site and analyzed for the presence of a particular analyte.

  3. Automatic computation of transfer functions

    DOE Patents [OSTI]

    Atcitty, Stanley; Watson, Luke Dale

    2015-04-14

    Technologies pertaining to the automatic computation of transfer functions for a physical system are described herein. The physical system is one of an electrical system, a mechanical system, an electromechanical system, an electrochemical system, or an electromagnetic system. A netlist in the form of a matrix comprises data that is indicative of elements in the physical system, values for the elements in the physical system, and structure of the physical system. Transfer functions for the physical system are computed based upon the netlist.

  4. Precision linear ramp function generator

    DOE Patents [OSTI]

    Jatko, W.B.; McNeilly, D.R.; Thacker, L.H.

    1984-08-01

    A ramp function generator is provided which produces a precise linear ramp function which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

  5. Sustainable Energy Solutions Task 2.0: Wind Turbine Reliability and Maintainability Enhancement through System-wide Structure Health Monitoring and Modifications to Rotating Components

    SciTech Connect (OSTI)

    Janet M Twomey, PhD

    2010-04-30

    EXECUTIVE SUMARRY An evaluation of nondestructive structural health monitoring methods was completed with over 132 documents, 37 specifically about wind turbines, summarized into a technology matrix. This matrix lists the technology, what can be monitored with this technology, and gives a short summary of the key aspects of the technology and its application. Passive and active acoustic emission equipment from Physical Acoustics Corp. and Acellent Technologies have been evaluated and selected for use in experimental state loading and fatigue tests of composite wind turbine blade materials. Acoustic Emission (AE) and Active Ultrasonic Testing (AUT), were applied to composite coupons with both simulated and actual damage. The results found that, while composites are more complicated in nature, compared to metallic structures, an artificial neural network analysis could still be used to determine damage. For the AE system, the failure mode could be determined (i.e. fiber breakage, delamination, etc.). The Acellent system has been evaluated to work well with composite materials. A test-rig for reliability testing of the rotating components was constructed. The research on the types of bearings used in the wind turbines indicated that in most of the designs, the main bearings utilized to support the shaft are cylindrical roller bearings. The accelerated degradation testing of a population of bearings was performed. Vibration and acoustic emission data was collected and analyzed in order to identify a representative degradation signal for each bearing to identify the initiation of the degradation process in the bearings. Afterwards, the RMS of the vibration signal from degradation initiation up to the end of the useful life of the bearing was selected to predict the remaining useful life of the bearing. This step included fitting Autoregressive Moving Average (ARMA) models to the degradation signals and approximating the probability distribution function (PDF) of remaining useful life based on the results of Monte-Carlo simulation of the ARMA models. This step was performed for different percentages of the degradation signal of each bearing. The accuracy of the proposed approach then was assessed by comparing the actual life of the bearing and the estimated life of the bearing from the developed models. The results were impressive and indicated that the accuracy of the models improved as more data was utilized in developing the ARMA models (we get closer to the end of the life of the bearing).

  6. High throughput reproducible cantilever functionalization

    DOE Patents [OSTI]

    Evans, Barbara R; Lee, Ida

    2014-01-21

    A method for functionalizing cantilevers is provided that includes providing a holder having a plurality of channels each having a width for accepting a cantilever probe and a plurality of probes. A plurality of cantilever probes are fastened to the plurality of channels of the holder by the spring clips. The wells of a well plate are filled with a functionalization solution, wherein adjacent wells in the well plate are separated by a dimension that is substantially equal to a dimension separating adjacent channels of the plurality of channels. Each cantilever probe that is fastened within the plurality of channels of the holder is applied to the functionalization solution that is contained in the wells of the well plate.

  7. High throughout reproducible cantilever functionalization

    DOE Patents [OSTI]

    Evans, Barbara R; Lee, Ida

    2014-11-25

    A method for functionalizing cantilevers is provided that includes providing a holder having a plurality of channels each having a width for accepting a cantilever probe and a plurality of probes. A plurality of cantilever probes are fastened to the plurality of channels of the holder by the spring clips. The wells of a well plate are filled with a functionalization solution, wherein adjacent wells in the well plate are separated by a dimension that is substantially equal to a dimension separating adjacent channels of the plurality of channels. Each cantilever probe that is fastened within the plurality of channels of the holder is applied to the functionalization solution that is contained in the wells of the well plate.

  8. Poly(ethylene oxide) functionalization

    DOE Patents [OSTI]

    Pratt, Russell Clayton

    2014-04-08

    A simple procedure is provided by which the hydroxyl termini of poly(ethylene oxide) can be appended with functional groups to a useful extent by reaction and precipitation. The polymer is dissolved in warmed toluene, treated with an excess of organic base and somewhat less of an excess of a reactive acylating reagent, reacted for several hours, then precipitated in isopropanol so that the product can be isolated as a solid, and salt byproducts are washed away. This procedure enables functionalization of the polymer while not requiring laborious purification steps such as solvent-solvent extraction or dialysis to remove undesirable side products.

  9. Phenomenological Relativistic Energy Density Functionals

    SciTech Connect (OSTI)

    Lalazissis, G. A.; Kartzikos, S.; Niksic, T.; Paar, N.; Vretenar, D.; Ring, P.

    2009-08-26

    The framework of relativistic nuclear energy density functionals is applied to the description of a variety of nuclear structure phenomena, not only in spherical and deformed nuclei along the valley of beta-stability, but also in exotic systems with extreme isospin values and close to the particle drip-lines. Dynamical aspects of exotic nuclear structure is explored using the fully consistent quasiparticle random-phase approximation based on the relativistic Hartree-Bogoliubov model. Recent applications of energy density functionals with explicit density dependence of the meson-nucleon couplings are presented.

  10. Project X functional requirements specification

    SciTech Connect (OSTI)

    Holmes, S.D.; Henderson, S.D.; Kephart, R.; Kerby, J.; Kourbanis, I.; Lebedev, V.; Mishra, S.; Nagaitsev, S.; Solyak, N.; Tschirhart, R.; /Fermilab

    2012-05-01

    Project X is a multi-megawatt proton facility being developed to support a world-leading program in Intensity Frontier physics at Fermilab. The facility is designed to support programs in elementary particle and nuclear physics, with possible applications to nuclear energy research. A Functional Requirements Specification has been developed in order to establish performance criteria for the Project X complex in support of these multiple missions, and to assure that the facility is designed with sufficient upgrade capability to provide U.S. leadership for many decades to come. This paper will briefly review the previously described Functional Requirements, and then discuss their recent evolution.

  11. Physical unclonable functions: A primer

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bauer, Todd; Hamlet, Jason

    2014-11-01

    Physical unclonable functions (PUFs) make use of the measurable intrinsic randomness of physical systems to establish signatures for those systems. Thus, PUFs provide a means to generate unique keys that don't need to be stored in nonvolatile memory, and they offer exciting opportunities for new authentication and supply chain security technologies.

  12. Functional Insights from Structural Genomics

    SciTech Connect (OSTI)

    Forouhar,F.; Kuzin, A.; Seetharaman, J.; Lee, I.; Zhou, W.; Abashidze, M.; Chen, Y.; Montelione, G.; Tong, L.; et al

    2007-01-01

    Structural genomics efforts have produced structural information, either directly or by modeling, for thousands of proteins over the past few years. While many of these proteins have known functions, a large percentage of them have not been characterized at the functional level. The structural information has provided valuable functional insights on some of these proteins, through careful structural analyses, serendipity, and structure-guided functional screening. Some of the success stories based on structures solved at the Northeast Structural Genomics Consortium (NESG) are reported here. These include a novel methyl salicylate esterase with important role in plant innate immunity, a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel methyltransferase or AdoMet binding protein (A. fulgidus AF{_}0241), an ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B. melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP{_}1951), and a 12-stranded {beta}-barrel with a novel fold (V. parahaemolyticus VPA1032).

  13. Energy spectra and wave function of trigonometric Rosen-Morse potential as an effective quantum chromodynamics potential in D-dimensions

    SciTech Connect (OSTI)

    Deta, U. A.; Suparmi,; Cari,; Husein, A. S.; Yuliani, H.; Khaled, I. K. A.; Luqman, H.; Supriyanto

    2014-09-30

    The Energy Spectra and Wave Function of Schrodinger equation in D-Dimensions for trigonometric Rosen-Morse potential were investigated analytically using Nikiforov-Uvarov method. This potential captures the essential traits of the quark-gluon dynamics of Quantum Chromodynamics. The approximate energy spectra are given in the close form and the corresponding approximate wave function for arbitrary l-state (l ? 0) in D-dimensions are formulated in the form of differential polynomials. The wave function of this potential unnormalizable for general case. The wave function of this potential unnormalizable for general case. The existence of extra dimensions (centrifugal factor) and this potential increase the energy spectra of system.

  14. The time dependent propensity function for acceleration of spatial stochastic simulation of reactiondiffusion systems

    SciTech Connect (OSTI)

    Fu, Jin; Wu, Sheng; Li, Hong; Petzold, Linda R.

    2014-10-01

    The inhomogeneous stochastic simulation algorithm (ISSA) is a fundamental method for spatial stochastic simulation. However, when diffusion events occur more frequently than reaction events, simulating the diffusion events by ISSA is quite costly. To reduce this cost, we propose to use the time dependent propensity function in each step. In this way we can avoid simulating individual diffusion events, and use the time interval between two adjacent reaction events as the simulation stepsize. We demonstrate that the new algorithm can achieve orders of magnitude efficiency gains over widely-used exact algorithms, scales well with increasing grid resolution, and maintains a high level of accuracy.

  15. Functional Stability of a Mixed Microbial Consortium Producing PHA From Waste Carbon Sources

    SciTech Connect (OSTI)

    David N. Thompson; Erik R. Coats; William A. Smith; Frank J. Loge; Michael P. Wolcott

    2006-04-01

    Polyhydroxyalkanoates (PHAs) represent an environmentally-effective alternative to synthetic thermoplastics; however, current production practices are not sustainable. In this study, PHA production was accomplished in sequencing batch bioreactors utilizing real wastewaters and mixed microbial consortia from municipal activated sludge as inoculum. Polymer production reached 85%, 53%, and 10% of the cell dry weight from methanol-enriched pulp-and-paper mill foul condensate, fermented municipal primary solids, and biodiesel wastewater, respectively. Employing denaturing gradient gel electrophoresis of 16S-rDNA from PCR-amplified DNA extracts, distinctly different communities were observed between and within wastewaters following enrichment. Most importantly, functional stability was maintained despite differing and contrasting microbial populations.

  16. TRIDAC host computer functional specification

    SciTech Connect (OSTI)

    Hilbert, S.M.; Hunter, S.L.

    1983-08-23

    The purpose of this document is to outline the baseline functional requirements for the Triton Data Acquisition and Control (TRIDAC) Host Computer Subsystem. The requirements presented in this document are based upon systems that currently support both the SIS and the Uranium Separator Technology Groups in the AVLIS Program at the Lawrence Livermore National Laboratory and upon the specific demands associated with the extended safe operation of the SIS Triton Facility.

  17. Precision linear ramp function generator

    DOE Patents [OSTI]

    Jatko, W. Bruce (Knoxville, TN); McNeilly, David R. (Maryville, TN); Thacker, Louis H. (Knoxville, TN)

    1986-01-01

    A ramp function generator is provided which produces a precise linear ramp unction which is repeatable and highly stable. A derivative feedback loop is used to stabilize the output of an integrator in the forward loop and control the ramp rate. The ramp may be started from a selected baseline voltage level and the desired ramp rate is selected by applying an appropriate constant voltage to the input of the integrator.

  18. Semiclassical propagation of Wigner functions

    SciTech Connect (OSTI)

    Dittrich, T.; Gomez, E. A.; Pachon, L. A.

    2010-06-07

    We present a comprehensive study of semiclassical phase-space propagation in the Wigner representation, emphasizing numerical applications, in particular as an initial-value representation. Two semiclassical approximation schemes are discussed. The propagator of the Wigner function based on van Vleck's approximation replaces the Liouville propagator by a quantum spot with an oscillatory pattern reflecting the interference between pairs of classical trajectories. Employing phase-space path integration instead, caustics in the quantum spot are resolved in terms of Airy functions. We apply both to two benchmark models of nonlinear molecular potentials, the Morse oscillator and the quartic double well, to test them in standard tasks such as computing autocorrelation functions and propagating coherent states. The performance of semiclassical Wigner propagation is very good even in the presence of marked quantum effects, e.g., in coherent tunneling and in propagating Schroedinger cat states, and of classical chaos in four-dimensional phase space. We suggest options for an effective numerical implementation of our method and for integrating it in Monte-Carlo-Metropolis algorithms suitable for high-dimensional systems.

  19. Design Principles for Materials with Magnetic Functionality ...

    Office of Scientific and Technical Information (OSTI)

    Design Principles for Materials with Magnetic Functionality Citation Details In-Document Search Title: Design Principles for Materials with Magnetic Functionality This report ...

  20. Power Function Review (pbl/rates)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    PFR Public Comments Firstgov Power Function Review (PFR) Summary: This area of the Power Services web site provides information related to the Power Function Review (PFR). The PFR...

  1. Building a Universal Nuclear Energy Density Functional

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Building a Universal Nuclear Energy Density Functional Building a Universal Nuclear Energy Density Functional VaryMatrix.png Collaboration with mathematicians and computational...

  2. Functional Design Engineering Inc | Open Energy Information

    Open Energy Info (EERE)

    Functional Design Engineering Inc Jump to: navigation, search Name: Functional Design Engineering Inc Region: United States Sector: Marine and Hydrokinetic Website:...

  3. Window taper functions for subaperture processing. (Technical...

    Office of Scientific and Technical Information (OSTI)

    Window taper functions for subaperture processing. Citation Details In-Document Search Title: Window taper functions for subaperture processing. You are accessing a document ...

  4. Window taper functions for subaperture processing. (Technical...

    Office of Scientific and Technical Information (OSTI)

    Window taper functions for subaperture processing. Citation Details In-Document Search Title: Window taper functions for subaperture processing. It is well known that the spectrum ...

  5. Translocator Protein Structure and Function | Stanford Synchrotron...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Translocator Protein Structure and Function Monday, November 30, 2015 Translocator protein (TSPO) is an ancient conserved protein whose functions in bacteria and higher eukaryotes...

  6. Maintaining Your Air Conditioner | Department of Energy

    Energy Savers [EERE]

    Guidance Guidance internet-security.jpg Cybersecurity Documents in italics are currently under revision: Cybersecurity Strategy Cybersecurity Architecture OMB Requirements Records Management Employee Separation: Completing HQ F 3293.1, Sec. 7c Centers of Excellence (pdf) DOD 5015.02-STD, Records Management Applications Design Criteria Standards NARA Bulletins Procedures and Instructions Records Management Handbook Web DigitalGov Required Web Content and Links

    Exchangers for Solar Water

  7. Maintaining System Air Quality; Industrial Technologies Program...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... IOF focuses on the following eight energy and resource intensive industries: * Aluminum * Forest Products * Metal Casting * Petroleum * Chemicals * Glass * Mining * Steel The ...

  8. Authenticating concealed private data while maintaining concealment

    DOE Patents [OSTI]

    Thomas, Edward V. (Albuquerque, NM); Draelos, Timothy J. (Albuquerque, NM)

    2007-06-26

    A method of and system for authenticating concealed and statistically varying multi-dimensional data comprising: acquiring an initial measurement of an item, wherein the initial measurement is subject to measurement error; applying a transformation to the initial measurement to generate reference template data; acquiring a subsequent measurement of an item, wherein the subsequent measurement is subject to measurement error; applying the transformation to the subsequent measurement; and calculating a Euclidean distance metric between the transformed measurements; wherein the calculated Euclidean distance metric is identical to a Euclidean distance metric between the measurement prior to transformation.

  9. Maintain Pumping Systems Effectively; Industrial Technologies...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Effectively Effective pump maintenance allows industrial plants to keep pumps operating well, to detect problems in time to schedule repairs, and to avoid early pump failures. ...

  10. Maintaining the Stockpile | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    continuously assesses and evaluates each nuclear weapon to certify its reliability and to detect andor anticipate any potential problems that may come about as a result of aging. ...

  11. Maintaining the Stockpile | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    wave produced by the impact passes through the plutonium, and diagnostic Los Alamos Neutron Science Center LANSCE provides the scientific community with intense sources of...

  12. Maintaining the Stockpile | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    from 11 States Parties to the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) and one representative from the United Nations Office for Disarmament Affairs. ...

  13. A tool for maintaining good combustion

    SciTech Connect (OSTI)

    Lang, B.

    1996-05-01

    There is a long list of {open_quotes}tools{close_quotes} used by waste-to-energy control room operators to keep the plant operating in accord with regulations. In many plants, the list includes a camera to view inside the furnace. And now, more plants are finding cameras can be useful in several locations within the furnace environment.

  14. Maintaining Your Air Conditioner | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Condensate Drains Occasionally pass a stiff wire through the unit's drain channels. Clogged drain channels prevent a unit from reducing humidity, and the resulting excess moisture ...

  15. FUNCTION GENERATOR FOR ANALOGUE COMPUTERS

    DOE Patents [OSTI]

    Skramstad, H.K.; Wright, J.H.; Taback, L.

    1961-12-12

    An improved analogue computer is designed which can be used to determine the final ground position of radioactive fallout particles in an atomic cloud. The computer determines the fallout pattern on the basis of known wind velocity and direction at various altitudes, and intensity of radioactivity in the mushroom cloud as a function of particle size and initial height in the cloud. The output is then displayed on a cathode-ray tube so that the average or total luminance of the tube screen at any point represents the intensity of radioactive fallout at the geographical location represented by that point. (AEC)

  16. US Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1988-01-01

    This document provides functional organization charts for all NRC Offices and Regions, and their components.

  17. US Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1986-11-30

    Functional organization charts for the NRC Commission Offices, Divisions, and Branches are presented.

  18. Brownian dynamics without Green's functions

    SciTech Connect (OSTI)

    Delong, Steven; Donev, Aleksandar; Usabiaga, Florencio Balboa; Delgado-Buscalioni, Rafael; Griffith, Boyce E.; Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York 10016

    2014-04-07

    We develop a Fluctuating Immersed Boundary (FIB) method for performing Brownian dynamics simulations of confined particle suspensions. Unlike traditional methods which employ analytical Green's functions for Stokes flow in the confined geometry, the FIB method uses a fluctuating finite-volume Stokes solver to generate the action of the response functions on the fly. Importantly, we demonstrate that both the deterministic terms necessary to capture the hydrodynamic interactions among the suspended particles, as well as the stochastic terms necessary to generate the hydrodynamically correlated Brownian motion, can be generated by solving the steady Stokes equations numerically only once per time step. This is accomplished by including a stochastic contribution to the stress tensor in the fluid equations consistent with fluctuating hydrodynamics. We develop novel temporal integrators that account for the multiplicative nature of the noise in the equations of Brownian dynamics and the strong dependence of the mobility on the configuration for confined systems. Notably, we propose a random finite difference approach to approximating the stochastic drift proportional to the divergence of the configuration-dependent mobility matrix. Through comparisons with analytical and existing computational results, we numerically demonstrate the ability of the FIB method to accurately capture both the static (equilibrium) and dynamic properties of interacting particles in flow.

  19. Structures and Functions of Oligosaccharins

    SciTech Connect (OSTI)

    Albersheim, Peter

    1995-12-01

    We have made considerable progress during the 2.5 year funding period just ending in our studies of the structures and functions of oligosaccharide signal molecules (oligosaccharins). We have emphasized studies of the enzymes that solubilize, process, and degrade oligosaccharins and of the proteins that inhibit those enzymes. We have been especially interested in elucidating how oligosaccharins and their processing enzymes participate in determining the outcome of challenges to plants by pathogenic microbes. We have studied, to a lesser extent, the roles of oligosaccharins in plant growth and development. Abstracts of papers describing results acquired with support from this grant that have been published, submitted, or in preparation are presented to summarize the progress made during the last two and one half years. The report highlights the most important contributions made in our oiigosaccharin research during this time period, and the corresponding abstract is referenced. Results of work in progress are described primarily in conjunction with our application for continued support.

  20. Alkane functionalization at ([mu]-Oxo)diiron(III) centers

    SciTech Connect (OSTI)

    Leising, R.A.; Kim, J.; Perez, M.A.; Que, L. Jr. )

    1993-10-20

    The reactivity of ([mu]-oxo)diferric complexes with [sup t]BuOOH (TBHP) for the functionalization of alkanes in CH[sub 3]CN has been investigated as part of our efforts to model dinuclear sites in nonheme iron enzymes. [Fe[sub 2](TPA)[sub 2]O(OAc)](CIO[sub 4])[sub 3] (1) (TPA = tris(2-pyridylmethyl)amine, OAc = acetate) is an efficient catalyst for cyclohexane oxidation, affording cyclohexanol (A, 9 equiv), cyclohexanone (K, 11 equiv), and (tert-butylperoxy)cyclohexane (P, 16 equiv) in 0.25 h at ambient temperature and pressure under an argon atmosphere. The catalyst is remarkably robust, as indicated by the [sup 1]H NMR and UV-vis spectra of the reaction mixture during the catalytic reaction and by its ability to maintain its turnover efficiency with subsequent additions of oxidant. The catalytic mechanism for TBHP utilization was explored by observing the effects of varying the tripodal ligands on the ([mu]-oxo)([mu]-carboxylato)diferric catalysts and varying the bridge on Fe[sub 2]O(TPA)[sub 2] catalysts. The (A + K)/P ratio increased as the ligands became more electron donating. Solvent also played an important role in determining the partitioning of products between A + K and P, with benzonitrile favoring hydroxylated products at the expense of P and pyridine having the opposite effect. 49 refs., 2 figs., 3 tabs.

  1. Tn-seq of Caulobacter crescentus under uranium stress reveals genes essential for detoxification and stress tolerance

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yung, Mimi C.; Park, Dan M.; Overton, K. Wesley; Blow, Matthew J.; Hoover, Cindi A.; Smit, John R.; Murray, Sean R.; Ricci, Dante P.; Christen, Beat; Bowman, Grant R.; et al

    2015-07-20

    Ubiquitous aquatic bacterium Caulobacter crescentus is highly resistant to uranium (U) and facilitates U biomineralization and thus holds promise as an agent of U bioremediation. In order to gain an understanding of how C. crescentus tolerates U, we employed transposon (Tn) mutagenesis paired with deep sequencing (Tn-seq) in a global screen for genomic elements required for U resistance. Of the 3,879 annotated genes in the C. crescentus genome, 37 were found to be specifically associated with fitness under U stress, 15 of which were subsequently tested through mutational analysis. Systematic deletion analysis revealed that mutants lacking outer membrane transporters (rsaFamore » and rsaFb), a stress-responsive transcription factor (cztR), or a ppGpp synthetase/hydrolase (spoT) exhibited a significantly lower survival rate under U stress. RsaFa and RsaFb, which are homologues of TolC in Escherichia coli, have previously been shown to mediate S-layer export. Transcriptional analysis revealed upregulation of rsaFa and rsaFb by 4- and 10-fold, respectively, in the presence of U. We additionally show that rsaFa mutants accumulated higher levels of U than the wild type, with no significant increase in oxidative stress levels. These results suggest a function for RsaFa and RsaFb in U efflux and/or maintenance of membrane integrity during U stress. In addition, we present data implicating CztR and SpoT in resistance to U stress. Together, our findings reveal novel gene targets that are key to understanding the molecular mechanisms of U resistance in C. crescentus.« less

  2. DOE-STD-1181-2004; Facility Maintenance Management Functional...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... maintenance management personnel shall demonstrate a working level knowledge of industrial property management practices as related to stores, spare parts, and essential materials. ...

  3. Predicting Stability Constants for Uranyl Complexes Using Density Functional Theory

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Vukovic, Sinisa; Hay, Benjamin P.; Bryantsev, Vyacheslav S.

    2015-04-02

    The ability to predict the equilibrium constants for the formation of 1:1 uranyl:ligand complexes (log K1 values) provides the essential foundation for the rational design of ligands with enhanced uranyl affinity and selectivity. We also use density functional theory (B3LYP) and the IEFPCM continuum solvation model to compute aqueous stability constants for UO22+ complexes with 18 donor ligands. Theoretical calculations permit reasonably good estimates of relative binding strengths, while the absolute log K1 values are significantly overestimated. Accurate predictions of the absolute log K1 values (root mean square deviation from experiment < 1.0 for log K1 values ranging from 0more » to 16.8) can be obtained by fitting the experimental data for two groups of mono and divalent negative oxygen donor ligands. The utility of correlations is demonstrated for amidoxime and imide dioxime ligands, providing a useful means of screening for new ligands with strong chelate capability to uranyl.« less

  4. Predicting Stability Constants for Uranyl Complexes Using Density Functional Theory

    SciTech Connect (OSTI)

    Vukovic, Sinisa; Hay, Benjamin P.; Bryantsev, Vyacheslav S.

    2015-04-02

    The ability to predict the equilibrium constants for the formation of 1:1 uranyl:ligand complexes (log K1 values) provides the essential foundation for the rational design of ligands with enhanced uranyl affinity and selectivity. We also use density functional theory (B3LYP) and the IEFPCM continuum solvation model to compute aqueous stability constants for UO22+ complexes with 18 donor ligands. Theoretical calculations permit reasonably good estimates of relative binding strengths, while the absolute log K1 values are significantly overestimated. Accurate predictions of the absolute log K1 values (root mean square deviation from experiment < 1.0 for log K1 values ranging from 0 to 16.8) can be obtained by fitting the experimental data for two groups of mono and divalent negative oxygen donor ligands. The utility of correlations is demonstrated for amidoxime and imide dioxime ligands, providing a useful means of screening for new ligands with strong chelate capability to uranyl.

  5. US Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1990-08-15

    Functional organization charts for the US Nuclear Regulatory Commission offices, divisions, and branches are presented in this document.

  6. US Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1990-04-01

    Functional organization charts for the US Nuclear Regulatory Commission offices, divisions, and branches are presented in this document.

  7. Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

    SciTech Connect (OSTI)

    Premkumar, Lakshmanane, E-mail: p.lakshmanane@imb.uq.edu.au; Heras, Begoa; Duprez, Wilko; Walden, Patricia; Halili, Maria; Kurth, Fabian; Fairlie, David P.; Martin, Jennifer L., E-mail: p.lakshmanane@imb.uq.edu.au [University of Queensland, St Lucia, QLD 4067 (Australia)

    2013-10-01

    The gene product of M. tuberculosis Rv2969c is shown to be a disulfide oxidase enzyme that has a canonical DsbA-like fold with novel structural and functional characteristics. The bacterial disulfide machinery is an attractive molecular target for developing new antibacterials because it is required for the production of multiple virulence factors. The archetypal disulfide oxidase proteins in Escherichia coli (Ec) are DsbA and DsbB, which together form a functional unit: DsbA introduces disulfides into folding proteins and DsbB reoxidizes DsbA to maintain it in the active form. In Mycobacterium tuberculosis (Mtb), no DsbB homologue is encoded but a functionally similar but structurally divergent protein, MtbVKOR, has been identified. Here, the Mtb protein Rv2969c is investigated and it is shown that it is the DsbA-like partner protein of MtbVKOR. It is found that it has the characteristic redox features of a DsbA-like protein: a highly acidic catalytic cysteine, a highly oxidizing potential and a destabilizing active-site disulfide bond. Rv2969c also has peptide-oxidizing activity and recognizes peptide segments derived from the periplasmic loops of MtbVKOR. Unlike the archetypal EcDsbA enzyme, Rv2969c has little or no activity in disulfide-reducing and disulfide-isomerase assays. The crystal structure of Rv2969c reveals a canonical DsbA fold comprising a thioredoxin domain with an embedded helical domain. However, Rv2969c diverges considerably from other DsbAs, including having an additional C-terminal helix (H8) that may restrain the mobility of the catalytic helix H1. The enzyme is also characterized by a very shallow hydrophobic binding surface and a negative electrostatic surface potential surrounding the catalytic cysteine. The structure of Rv2969c was also used to model the structure of a paralogous DsbA-like domain of the Ser/Thr protein kinase PknE. Together, these results show that Rv2969c is a DsbA-like protein with unique properties and a limited substrate-binding specificity.

  8. Property:Distributed Generation Function | Open Energy Information

    Open Energy Info (EERE)

    Function Jump to: navigation, search Property Name Distributed Generation Function Property Type Page Description A description of the function(s) for which the Distributed...

  9. Ecological function and resilience: Neglected criteria for environmental impact assessment and ecological risk analysis

    SciTech Connect (OSTI)

    Cairns, J. Jr.; Niederlehner, B.R. . Univ. Center for Environmental and Hazardous Materials Studies)

    1993-01-01

    The importance of establishing methods for determining ecological function and resilience transcends scientific interest; these methods are important to sustained societal use of ecosystems and long-term productivity. Essential services that ecosystems provide to human society include water purification, oxygen production, carbon storage, climate regulation, and production of food, wood, and medicinal drugs. Although man is dependent upon these services, human understanding of the dynamics of ecosystem function is limited. Man can detect gross impairment of ecosystem function or resilience after the fact. However, protecting ecosystem health necessitates detecting adverse trends in ecological function, rather than reacting when the system collapses. The information to date is inadequate for predicting subtle changes or incremental trends. Once ecosystems are damaged and therefore providing diminished services, it is important to determine when they will be restored to an approximation of their predisturbance condition. For those ecosystems unlikely to recover on their own, management techniques may enhance recovery processes. Information about response of ecosystem function to human actions and relative resilience of alternative ecosystems can facilitate decision-making under the National Environmental Policy Act (NEPA).

  10. Polarized structure functions in nuclear matter

    SciTech Connect (OSTI)

    Tehrani, S. Atashbar; Khorramian, A. N.; Monfared, S. Taheri; Arbabifar, F.

    2011-10-24

    We present a comprehensive analysis of the structure functions for the polarized nuclei {sup 3}He, and focus on the polarized distribution functions and light-cone momentum distributions of protons and neutrons. We demonstrate that the first moment of the {sup 3}He structure function can provide an incisive test of the Bjorken sum rule.

  11. A description of the location and structure of the essential spectrum of a model operator in a subspace of a Fock space

    SciTech Connect (OSTI)

    Yodgorov, G R; Ismail, F; Muminov, Z I

    2014-12-31

    We consider a certain model operator acting in a subspace of a fermionic Fock space. We obtain an analogue of Faddeev's equation. We describe the location of the essential spectrum of the operator under consideration and show that the essential spectrum consists of the union of at most four segments. Bibliography: 19 titles.

  12. Functionalized lignin, rubber containing functionalized lignin and products containing such rubber composition

    DOE Patents [OSTI]

    Benko, David Andrew; Hahn, Bruce Raymond; Cohen, Martin Paul; Dirk, Shawn Matthew; Cicotte, Kirsten Nicole

    2014-03-04

    The invention relates to functionalized lignin, rubber compositions which contain functionalized lignin and to products which have at least one component comprised of such rubber composition.

  13. Functional Encyclopedia of Bacteria and Archaea

    SciTech Connect (OSTI)

    Blow, M. J.; Deutschbauer, A. M.; Hoover, C. A.; Lamson, J.; Lamson, J.; Price, M. N.; Waters, J.; Wetmore, K. M.; Bristow, J.; Arkin, A. P.

    2013-03-20

    Bacteria and Archaea exhibit a huge diversity of metabolic capabilities with fundamental importance in the environment, and potential applications in biotechnology. However, the genetic bases of these capabilities remain unclear due largely to an absence of technologies that link DNA sequence to molecular function. To address this challenge, we are developing a pipeline for high throughput annotation of gene function using mutagenesis, growth assays and DNA sequencing. By applying this pipeline to annotate gene function in 50 diverse microbes we hope to discover thousands of new gene functions and produce a proof of principle `Functional Encyclopedia of Bacteria and Archaea?.

  14. Functionalized active-nucleus complex sensor

    DOE Patents [OSTI]

    Pines, Alexander; Wemmer, David E.; Spence, Megan; Rubin, Seth

    2003-11-25

    A functionalized active-nucleus complex sensor that selectively associates with one or more target species, and a method for assaying and screening for one or a plurality of target species utilizing one or a plurality of functionalized active-nucleus complexes with at least two of the functionalized active-nucleus complexes having an attraction affinity to different corresponding target species. The functionalized active-nucleus complex has an active-nucleus and a targeting carrier. The method involves functionalizing an active-nucleus, for each functionalized active-nucleus complex, by incorporating the active-nucleus into a macromolucular or molecular complex that is capable of binding one of the target species and then bringing the macromolecular or molecular complexes into contact with the target species and detecting the occurrence of or change in a nuclear magnetic resonance signal from each of the active-nuclei in each of the functionalized active-nucleus complexes.

  15. Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis

    SciTech Connect (OSTI)

    Harrison, Anthony J.; Ramsay, Rochelle J.; Baker, Edward N.; Lott, J. Shaun

    2005-01-01

    MbtI, the putative isochorismate synthase essential for siderophore biosynthesis in M. tuberculosis, has been crystallized. Diffraction data have been collected to 1.8 resolution. Mycobacterium tuberculosis, the causative agent of tuberculosis, depends on the secretion of salicylate-based siderophores called mycobactins for the acquisition of extracellular iron, which is essential for the growth and virulence of the bacterium. The protein MbtI is thought to be the isochorismate synthase enzyme responsible for the conversion of chorismate to isochorismate, the first step in the salicylate production required for mycobactin biosynthesis. MbtI has been overexpressed in Escherichia coli, purified and crystallized. The crystals diffract to a maximum resolution of 1.8 . They belong to space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 51.8, b = 163.4, c = 194.9 , consistent with the presence of either two, three or four molecules in the asymmetric unit.

  16. The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt

    SciTech Connect (OSTI)

    Clements, Craig S.; Kjer-Nielsen, Lars; Kostenko, Lyudmila; McCluskey, James; Rossjohn, Jamie

    2006-01-01

    X-ray diffraction data were collected to 1.9 from crystals of HLA-G. Cobalt ions were found to be essential for the production of diffracting crystals. HLA-G is a nonclassical class I major histocompatibility complex (MHC) molecule that is primarily expressed at the foetalmaternal interface. Although the role of HLA-G has not been fully elucidated, current evidence suggests it protects the foetus from the maternal immune response. In this report, HLA-G (44 kDa) is characterized by expression in Escherichia coli. The inclusion bodies were refolded in complex with a peptide derived from histone H2A (RIIPRHLQL), purified and subsequently crystallized. Correct refolding was determined using two conformation-dependent antibodies. Cobalt ions were shown to be an essential ingredient for obtaining diffraction-quality crystals. The crystals, which diffracted to 1.9 resolution, belonged to space group P3{sub 2}2{sub 1}, with unit-cell parameters a = b = 77.15, c = 151.72 .

  17. Accurate evaluation of pionium wave functions

    SciTech Connect (OSTI)

    Suebka, P.; Yan, Y.

    2004-09-01

    A suitable numerical approach based on Sturmian functions is employed to solve the pionium problem for both local and nonlocal potentials. The approach accounts for both the short-ranged strong interaction and the long-ranged Coulomb force and provides accurately the wave function and binding energy of pionium. It is found that the ground-state pionium wave function in realistic pion-pion strong interactions might be considerably different from the hydrogen-like one at a small distance.

  18. Functional Area Qualification Standard Qualification Cards

    Broader source: Energy.gov [DOE]

    A key element for the Department’s Technical Qualification Programs is a set of common Functional Area Qualification Standards (FAQS) and associated Job Task Analyses (JTA). These standards are developed for various functional areas of responsibility in the Department, including oversight of safety management programs identified as hazard controls in Documented Safety Analyses (DSA). For each functional area, the FAQS identify the minimum technical competencies and supporting knowledge and skills for a typical qualified individual working in the area.

  19. Nuclear Safety Specialist Functional Area Qualification Standard

    Energy Savers [EERE]

    83-2007 November 2007 DOE STANDARD NUCLEAR SAFETY SPECIALIST FUNCTIONAL AREA QUALIFICATION ... Center (NTC) * Institute of Nuclear Power Operations (INPO) * American Institute ...

  20. Nuclear Explosives Safety Study Functional Area Qualification...

    Energy Savers [EERE]

    85-2007 September 2007 DOE STANDARD NUCLEAR EXPLOSIVE SAFETY STUDY FUNCTIONAL AREA QUALIFICATION ... bombs, including: * Radar fuses * Contact fuses * Timer fuses * Power supplies b. ...

  1. dual-function | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Novel Dual Functional Membrane for Controlling Carbon Dioxide Emissions from Fossil Fueled Power Plants Project No.: FG26-04NT42120 Microstructure of the composite membrane ...

  2. Guidance on Inherently Governmental Functions | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    Federal law prohibits contractors from performing "inherently governmental functions." This guidance is designed to provide the basic rules applicable to the Department....

  3. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    nanosheets for novel functions. The substitution of oil in place of air creates a raft of new opportunities for the engineering and production of peptoid nanosheets. For...

  4. Uncertainty Quantification for Nuclear Density Functional Theory...

    Office of Scientific and Technical Information (OSTI)

    Uncertainty Quantification for Nuclear Density Functional Theory and Information Content of New Measurements Citation Details In-Document Search This content will become publicly...

  5. Safety Software Quality Assurance Functional Area Qualification...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    72-2011, Safety Software Quality Assurance Functional Area Qualification Standard by Diane Johnson This SSQA FAQS identifies the minimum technical competency requirements for DOE...

  6. Contrasting soil microbial community functional structures in...

    Office of Scientific and Technical Information (OSTI)

    two major landscapes of the Tibetan alpine meadow Prev Next Title: Contrasting soil microbial community functional structures in two major landscapes of the Tibetan alpine...

  7. Building a Universal Nuclear Energy Density Functional

    SciTech Connect (OSTI)

    Bertulani, Carlos A.

    2014-09-10

    This grant had two components: Density functional theory and pairing and Nuclear reactions. This final report summarizes the activities for this SciDAC-2 project.

  8. Critical function and success path summary display

    DOE Patents [OSTI]

    Scarola, Kenneth; Jamison, David S.; Manazir, Richard M.; Rescorl, Robert L.; Harmon, Daryl L.

    1995-01-01

    The content of and hierarchical access to three levels of display pages containing information on critical function monitoring and success path monitoring.

  9. Functionalized High Performance Polymer Membranes for Separation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Functionalized High Performance Polymer Membranes for Separation of Carbon Dioxide and Methane Previous Next List Natalia Blinova and Frantisek Svec, J. Mater. Chem. A, 2, 600-604...

  10. Beyond simple exponential correlation functions and equilibrium...

    Office of Scientific and Technical Information (OSTI)

    Title: Beyond simple exponential correlation functions and equilibrium dynamics in x-ray photon correlation spectroscopy Authors: Madsen, Anders ; Leheny, Robert L. ; Guo, Hongyu ; ...

  11. Crystal Structure and Functional Analysis Identify Evolutionary...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    domains are considered to be markers for tRNA synthetase-associated functions beyond translation (1). Although their appearance correlates with the increase of biological...

  12. Functionalized Polyacrylamide Monolith for Rapid Bacteria Pathogen...

    Office of Scientific and Technical Information (OSTI)

    Bacteria Pathogen Detection in Human Blood. Citation Details In-Document Search Title: Functionalized Polyacrylamide Monolith for Rapid Bacteria Pathogen Detection in Human Blood. ...

  13. Methods of electrophoretic deposition for functionally graded...

    Office of Scientific and Technical Information (OSTI)

    In another embodiment, a method for forming a functionally graded porous nanostructure includes adding particles of an impurity and a solution to an EPD chamber, applying a voltage ...

  14. Contrasting soil microbial community functional structures in...

    Office of Scientific and Technical Information (OSTI)

    Contrasting soil microbial community functional structures in two major landscapes of the Tibetan alpine meadow Prev Next Title: Contrasting soil microbial community...

  15. Guidance on Inherently Governmental Functions | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Guidance on Inherently Governmental Functions Federal law prohibits contractors from ... by one or more sources of Federal law, (3) notes the special considerations ...

  16. Grid Connected Functionalities | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Lead Performer: National Renewable Energy Laboratory (NREL) Objective The objective of Grid Connected Functionality is to develop planning and establish strategic directions, along ...

  17. Quality Assurance Functional Area Qualification Standard - DOE...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    establishes common functional area competency requirements for DOE personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical QA...

  18. Quality Assurance Functional Area Qualification Standard - DOE...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    common functional area competency requirements for all DOE QA personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical...

  19. Methods of electrophoretic deposition for functionally graded...

    Office of Scientific and Technical Information (OSTI)

    Methods of electrophoretic deposition for functionally graded porous nanostructures and ... and depositing the material onto surfaces of the particles of the impurity to form ...

  20. The integrated Earth System Model Version 1: formulation and functionality

    SciTech Connect (OSTI)

    Collins, William D.; Craig, Anthony P.; Truesdale, John E.; Di Vittorio, Alan; Jones, Andrew D.; Bond-Lamberty, Benjamin; Calvin, Katherine V.; Edmonds, James A.; Kim, Son H.; Thomson, Allison M.; Patel, Pralit L.; Zhou, Yuyu; Mao, Jiafu; Shi, Xiaoying; Thornton, Peter E.; Chini, Louise M.; Hurtt, George C.

    2015-07-23

    The integrated Earth System Model (iESM) has been developed as a new tool for pro- jecting the joint human/climate system. The iESM is based upon coupling an Integrated Assessment Model (IAM) and an Earth System Model (ESM) into a common modeling in- frastructure. IAMs are the primary tool for describing the human–Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species, land use and land cover change, and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. The iESM project integrates the economic and human dimension modeling of an IAM and a fully coupled ESM within a sin- gle simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore- omitted feedbacks between natural and societal drivers, we can improve scientific under- standing of the human–Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper de- scribes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.

  1. The integrated Earth system model version 1: formulation and functionality

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Collins, W. D.; Craig, A. P.; Truesdale, J. E.; Di Vittorio, A. V.; Jones, A. D.; Bond-Lamberty, B.; Calvin, K. V.; Edmonds, J. A.; Kim, S. H.; Thomson, A. M.; et al

    2015-07-23

    The integrated Earth system model (iESM) has been developed as a new tool for projecting the joint human/climate system. The iESM is based upon coupling an integrated assessment model (IAM) and an Earth system model (ESM) into a common modeling infrastructure. IAMs are the primary tool for describing the human–Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species (SLS), land use and land cover change (LULCC), and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. Themore » iESM project integrates the economic and human-dimension modeling of an IAM and a fully coupled ESM within a single simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore-omitted feedbacks between natural and societal drivers, we can improve scientific understanding of the human–Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper describes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.« less

  2. Eta Structure Function via Photo-production

    SciTech Connect (OSTI)

    Ghahramany, N.; Ghanaatian, M.; Bazrafshan, A.

    2008-04-21

    By using isobar model and the latest data, the structure function of Eta particle is calculated in the process of photo-production. This calculation is carried out for photon energy range of 0.750-3 GeV. The variations of the structure function are given in terms of scattering angle for different incoming photon energy.

  3. Quality Assurance Functional Area Qualification Standard

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2002-04-22

    Replaced by DOE-1150-2013 This QA Functional Area Qualification Standard establishes common functional area competency requirements for DOE personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical QA activities impacting the safe operation of defense nuclear facilities.

  4. Quality Assurance Functional Area Qualification Standard

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2013-12-02

    The Quality Assurance (QA) Functional Area Qualification Standard (FAQS) establishes common functional area competency requirements for all DOE QA personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical activities that could impact the safe operation of DOE’s defense nuclear facilities.

  5. Network architecture functional description and design

    SciTech Connect (OSTI)

    Stans, L.; Bencoe, M.; Brown, D.; Kelly, S.; Pierson, L.; Schaldach, C.

    1989-05-25

    This report provides a top level functional description and design for the development and implementation of the central network to support the next generation of SNL, Albuquerque supercomputer in a UNIX{reg sign} environment. It describes the network functions and provides an architecture and topology.

  6. Cross-Linked Conjugated Polymer Fibrils: Robust Nanowires from Functional Polythiophene Diblock Copolymers

    SciTech Connect (OSTI)

    Hammer, Brenton A. G.; Bokel, Felicia A.; Hayward, Ryan C.; Emrick, Todd

    2011-09-27

    A series of poly(3-hexyl thiophene) (P3HT)-based diblock copolymers were prepared and examined in solution for their assembly into fibrils, and post-assembly cross-linking into robust nanowire structures. P3HT-b-poly(3-methanol thiophene) (P3MT), and P3HT-b-poly(3-aminopropyloxymethyl thiophene) (P3AmT) diblock copolymers were synthesized using Grignard metathesis (GRIM) polymerization. Fibrils formed from solution assembly of these copolymers are thus decorated with hydroxyl and amine functionality, and cross-linking is achieved by reaction of diisocyanates with the hydroxyl and amine groups. A variety of cross-linked structures, characterized by transmission electron microscopy (TEM), were produced by this method, including dense fibrillar sheets, fibril bundles, or predominately individual fibrils, depending on the chosen reaction conditions. In solution, the cross-linked fibrils maintained their characteristic vibronic structure in solvents that would normally disrupt (dissolve) the structures.

  7. Rendering graphene supports hydrophilic with non-covalent aromatic functionalization for transmission electron microscopy

    SciTech Connect (OSTI)

    Pantelic, Radosav S., E-mail: pantelic@imbb.forth.gr [National Cancer Institute, 50 South Drive, Building 50, Room 4306, Bethesda, Maryland 20892 (United States); Fu, Wangyang; Schoenenberger, Christian [Department of Physics, University of Basel, Klingelbergstrasse 82, Basel CH-4056 (Switzerland); Stahlberg, Henning [Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, Mattenstrasse 26, WRO-1058, Basel CH-4058 (Switzerland)

    2014-03-31

    Amorphous carbon films have been routinely used to enhance the preparation of frozen-hydrated samples for transmission electron microscopy (TEM), either in retaining protein concentration, providing mechanical stability or dissipating sample charge. However, strong background signal from the amorphous carbon support obstructs that of the sample, and the insulating properties of thin amorphous carbon films preclude any efficiency in dispersing charge. Graphene addresses the limitations of amorphous carbon. Graphene is a crystalline material with virtually no phase or amplitude contrast and unparalleled, high electrical carrier mobility. However, the hydrophobic properties of graphene have prevented its routine application in Cryo-TEM. This Letter reports a method for rendering graphene TEM supports hydrophilica convenient approach maintaining graphene's structural and electrical properties based on non-covalent, aromatic functionalization.

  8. Design review plan for Multi-Function Waste Tank Facility (Project W-236A)

    SciTech Connect (OSTI)

    Renfro, G.G.

    1994-12-20

    This plan describes how the Multi-Function Waste Tank Facility (MWTF) Project conducts reviews of design media; describes actions required by Project participants; and provides the methodology to ensure that the design is complete, meets the technical baseline of the Project, is operable and maintainable, and is constructable. Project W-236A is an integrated project wherein the relationship between the operating contractor and architect-engineer is somewhat different than that of a conventional project. Working together, Westinghouse Hanford Company (WHC) and ICF Karser Hanford (ICF KH) have developed a relationship whereby ICF KH performs extensive design reviews and design verification. WHC actively participates in over-the-shoulder reviews during design development, performs a final review of the completed design, and conducts a formal design review of the Safety Class I, ASME boiler and Pressure Vessel Code items in accordance with WHC-CM-6-1, Standard Engineering Practices.

  9. Supervisory Essentials: Strategies for Success!

    Broader source: Energy.gov [DOE]

    Couse Description:  This course is designed to assist new first-line supervisors in developing the competencies they need to achieve their primary responsibilities, some of which include:...

  10. Low work function, stable thin films

    DOE Patents [OSTI]

    Dinh, Long N.; McLean, II, William; Balooch, Mehdi; Fehring, Jr., Edward J.; Schildbach, Marcus A.

    2000-01-01

    Generation of low work function, stable compound thin films by laser ablation. Compound thin films with low work function can be synthesized by simultaneously laser ablating silicon, for example, and thermal evaporating an alkali metal into an oxygen environment. For example, the compound thin film may be composed of Si/Cs/O. The work functions of the thin films can be varied by changing the silicon/alkali metal/oxygen ratio. Low work functions of the compound thin films deposited on silicon substrates were confirmed by ultraviolet photoelectron spectroscopy (UPS). The compound thin films are stable up to 500.degree. C. as measured by x-ray photoelectron spectroscopy (XPS). Tests have established that for certain chemical compositions and annealing temperatures of the compound thin films, negative electron affinity (NEA) was detected. The low work function, stable compound thin films can be utilized in solar cells, field emission flat panel displays, electron guns, and cold cathode electron guns.

  11. Oligomer functionalized nanotubes and composites formed therewith

    DOE Patents [OSTI]

    Zettl, Alexander K; Sainsbury, Toby; Frechet, Jean M.J.

    2014-03-18

    Disclosed herein is a sequential functionalization methodology for the covalent modification of nanotubes with between one and four repeat units of a polymer. Covalent attachment of oligomer units to the surface of nanotubes results in oligomer units forming an organic sheath around the nanotubes, polymer-functionalized-nanotubes (P-NTs). P-NTs possess chemical functionality identical to that of the functionalizing polymer, and thus provide nanoscale scaffolds which may be readily dispersed within a monomer solution and participate in the polymerization reaction to form a polymer-nanotube/polymer composite. Formation of polymer in the presence of P-NTs leads to a uniform dispersion of nanotubes within the polymer matrix, in contrast to aggregated masses of nanotubes in the case of pristine-NTs. The covalent attachment of oligomeric units to the surface of nanotubes represents the formation of a functional nanoscale building block which can be readily dispersed and integrated within the polymer to form a novel composite material.

  12. Density functional theory for carbon dioxide crystal

    SciTech Connect (OSTI)

    Chang, Yiwen; Mi, Jianguo Zhong, Chongli

    2014-05-28

    We present a density functional approach to describe the solid?liquid phase transition, interfacial and crystal structure, and properties of polyatomic CO{sub 2}. Unlike previous phase field crystal model or density functional theory, which are derived from the second order direct correlation function, the present density functional approach is based on the fundamental measure theory for hard-sphere repulsion in solid. More importantly, the contributions of enthalpic interactions due to the dispersive attractions and of entropic interactions arising from the molecular architecture are integrated in the density functional model. Using the theoretical model, the predicted liquid and solid densities of CO{sub 2} at equilibrium triple point are in good agreement with the experimental values. Based on the structure of crystal-liquid interfaces in different planes, the corresponding interfacial tensions are predicted. Their respective accuracies need to be tested.

  13. Functional electrolyte for lithium-ion batteries (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    Data Explorer Search Results Functional electrolyte for lithium-ion batteries Title: Functional electrolyte for lithium-ion batteries Functional electrolyte solvents include ...

  14. Functional electrolyte for lithium-ion batteries (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    Functional electrolyte for lithium-ion batteries Title: Functional electrolyte for lithium-ion batteries Functional electrolyte solvents include compounds having at least one ...

  15. Weak measurement and Bohmian conditional wave functions

    SciTech Connect (OSTI)

    Norsen, Travis; Struyve, Ward

    2014-11-15

    It was recently pointed out and demonstrated experimentally by Lundeen etal. that the wave function of a particle (more precisely, the wave function possessed by each member of an ensemble of identically-prepared particles) can be directly measured using weak measurement. Here it is shown that if this same technique is applied, with appropriate post-selection, to one particle from a perhaps entangled multi-particle system, the result is precisely the so-called conditional wave function of Bohmian mechanics. Thus, a plausibly operationalist method for defining the wave function of a quantum mechanical sub-system corresponds to the natural definition of a sub-system wave function which Bohmian mechanics uniquely makes possible. Similarly, a weak-measurement-based procedure for directly measuring a sub-systems density matrix should yield, under appropriate circumstances, the Bohmian conditional density matrix as opposed to the standard reduced density matrix. Experimental arrangements to demonstrate this behaviorand also thereby reveal the non-local dependence of sub-system state functions on distant interventionsare suggested and discussed. - Highlights: We study a direct measurement protocol for wave functions and density matrices. Weakly measured states of entangled particles correspond to Bohmian conditional states. Novel method of observing quantum non-locality is proposed.

  16. Proton structure functions at small x

    SciTech Connect (OSTI)

    Hentschinski, Martin

    2015-01-01

    Proton structure functions are measured in electron-proton collision through inelastic scattering of virtual photons with virtuality Q on protons; x denotes the momentum fraction carried by the struck parton. Proton structure functions are currently described with excellent accuracy in terms of scale dependent parton distribution functions, defined in terms of collinear factorization and DGLAP evolution in Q. With decreasing x however, parton densities increase and are ultimately expected to saturate. In this regime DGLAP evolution will finally break down and non-linear evolution equations w.r.t x are expected to take over. In the first part of the talk we present recent result on an implementation of physical DGLAP evolution. Unlike the conventional description in terms of parton distribution functions, the former describes directly the Q dependence of the measured structure functions. It is therefore physical insensitive to factorization scheme and scale ambiguities. It therefore provides a more stringent test of DGLAP evolution and eases the manifestation of (non-linear) small x effects. It however requires a precise measurement of both structure functions F2 and FL, which will be only possible at future facilities, such as an Electron Ion Collider. In the second part we present a recent analysis of the small x region of the combined HERA data on the structure function F2. We demonstrate that (linear) next-to-leading order BFKL evolution describes the effective Pomeron intercept, determined from the combined HERA data, once a resummation of collinear enhanced terms is included and the renormalization scale is fixed using the BLM optimal scale setting procedure. We also provide a detailed description of the Q and x dependence of the full structure functions F2 in the small x region, as measured at HERA. As a result, predictions for the structure function FL are found to be in agreement with the existing HERA data.

  17. Proton structure functions at small x

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hentschinski, Martin

    2015-01-01

    Proton structure functions are measured in electron-proton collision through inelastic scattering of virtual photons with virtuality Q on protons; x denotes the momentum fraction carried by the struck parton. Proton structure functions are currently described with excellent accuracy in terms of scale dependent parton distribution functions, defined in terms of collinear factorization and DGLAP evolution in Q. With decreasing x however, parton densities increase and are ultimately expected to saturate. In this regime DGLAP evolution will finally break down and non-linear evolution equations w.r.t x are expected to take over. In the first part of the talk we present recentmore » result on an implementation of physical DGLAP evolution. Unlike the conventional description in terms of parton distribution functions, the former describes directly the Q dependence of the measured structure functions. It is therefore physical insensitive to factorization scheme and scale ambiguities. It therefore provides a more stringent test of DGLAP evolution and eases the manifestation of (non-linear) small x effects. It however requires a precise measurement of both structure functions F2 and FL, which will be only possible at future facilities, such as an Electron Ion Collider. In the second part we present a recent analysis of the small x region of the combined HERA data on the structure function F2. We demonstrate that (linear) next-to-leading order BFKL evolution describes the effective Pomeron intercept, determined from the combined HERA data, once a resummation of collinear enhanced terms is included and the renormalization scale is fixed using the BLM optimal scale setting procedure. We also provide a detailed description of the Q and x dependence of the full structure functions F2 in the small x region, as measured at HERA. As a result, predictions for the structure function FL are found to be in agreement with the existing HERA data.« less

  18. Surface-functionalized mesoporous carbon materials

    DOE Patents [OSTI]

    Dai, Sheng; Gorka, Joanna; Mayes, Richard T.

    2016-02-02

    A functionalized mesoporous carbon composition comprising a mesoporous carbon scaffold having mesopores in which polyvinyl polymer grafts are covalently attached, wherein said mesopores have a size of at least 2 nm and up to 50 nm. Also described is a method for producing the functionalized mesoporous composition, wherein a reaction medium comprising a precursor mesoporous carbon, vinyl monomer, initiator, and solvent is subjected to sonication of sufficient power to result in grafting and polymerization of the vinyl monomer into mesopores of the precursor mesoporous carbon. Also described are methods for using the functionalized mesoporous carbon, particularly in extracting metal ions from metal-containing solutions.

  19. All-SiC Inductively Coupled Charger with Integrated Plug-in and Boost Functionalities for PEV Applications

    SciTech Connect (OSTI)

    Chinthavali, Madhu Sudhan; Campbell, Steven L; Tolbert, Leon M

    2016-01-01

    So far, vehicular power electronics integration is limited to the integration of on-board battery chargers (OBC) into the traction drive system and sometimes to the accessory dc/dc converters in plug-in electric vehicles (PEV). These integration approaches do not provide isolation from the grid although it is an important feature that is required for user interface systems that have grid connections. This is therefore a major limitation that needs to be addressed along with the integrated functionality. Furthermore, there is no previous study that proposes the integration of wireless charger with the other on-board components. This study features a unique way of combining the wired and wireless charging functionalities with vehicle side boost converter integration and maintaining the isolation to provide the best solution to the plug-in electric vehicle users. The new topology is additionally compared with commercially available OBC systems from manufacturers.

  20. Analytic cubic and quartic force fields using density-functional theory

    SciTech Connect (OSTI)

    Ringholm, Magnus; Gao, Bin; Thorvaldsen, Andreas J.; Ruud, Kenneth; Jonsson, Dan; High Performance Computing Group, University of TromsThe Arctic University of Norway, 9037 Troms ; Bast, Radovan; Ekstrm, Ulf; Helgaker, Trygve

    2014-01-21

    We present the first analytic implementation of cubic and quartic force constants at the level of KohnSham density-functional theory. The implementation is based on an open-ended formalism for the evaluation of energy derivatives in an atomic-orbital basis. The implementation relies on the availability of open-ended codes for evaluation of one- and two-electron integrals differentiated with respect to nuclear displacements as well as automatic differentiation of the exchangecorrelation kernels. We use generalized second-order vibrational perturbation theory to calculate the fundamental frequencies of methane, ethane, benzene, and aniline, comparing B3LYP, BLYP, and HartreeFock results. The HartreeFock anharmonic corrections agree well with the B3LYP corrections when calculated at the B3LYP geometry and from B3LYP normal coordinates, suggesting that the inclusion of electron correlation is not essential for the reliable calculation of cubic and quartic force constants.

  1. MDF Form and Function (Text Version)

    Broader source: Energy.gov [DOE]

    This is a text version of the Manufacturing Demonstration Facilities (MDF) Form and Function video, originally presented on March 12, 2012 at the MDF Workshop held in Chicago, Illinois.

  2. Safety Management Functions, Responsibilities, and Authorities Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-12-31

    This Manual defines safety management functions, responsibilities, and authorities for DOE senior management with responsibilities for line, support, oversight, and enforcement actions. Cancels DOE M 411.1-1B. Canceled by DOE O 450.2.

  3. Dipole rescattering and the nuclear structure function

    SciTech Connect (OSTI)

    Carvalho, F.; Goncalves, V. P.; Navarra, F. S.; Oliveira, E. G.

    2013-03-25

    In the framework of the dipole model, we study the effects of the dipole multiple scatterings in a nuclear target and compute the nuclear structure function. We compare different unitarization schemes and confront our results with the E665 data.

  4. Physicochemically functional ultrathin films by interfacial polymerization

    DOE Patents [OSTI]

    Lonsdale, Harold K.; Babcock, Walter C.; Friensen, Dwayne T.; Smith, Kelly L.; Johnson, Bruce M.; Wamser, Carl C.

    1990-01-01

    Interfacially-polymerized ultrathin films containing physicochemically functional groups are disclosed, both with and without supports. Various applications are disclsoed, including membrane electrodes, selective membranes and sorbents, biocompatible materials, targeted drug delivery, and narrow band optical absorbers.

  5. Crystallization and functionality of inorganic materials

    SciTech Connect (OSTI)

    Xue, Dongfeng, E-mail: dongfeng@ciac.jl.cn [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China) [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); School of Chemical Engineering, Dalian University of Technology, Dalian 116024 (China); Li, Keyan [School of Chemical Engineering, Dalian University of Technology, Dalian 116024 (China)] [School of Chemical Engineering, Dalian University of Technology, Dalian 116024 (China); Liu, Jun [Key Laboratory of Low Dimensional Materials and Application Technology, Ministry of Education, Faculty of Materials, Optoelectronics and Physics, Xiangtan University, 411105 (China)] [Key Laboratory of Low Dimensional Materials and Application Technology, Ministry of Education, Faculty of Materials, Optoelectronics and Physics, Xiangtan University, 411105 (China); Sun, Congting; Chen, Kunfeng [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China) [State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); School of Chemical Engineering, Dalian University of Technology, Dalian 116024 (China)

    2012-10-15

    In this article, we briefly summarized our recent work on the studies of crystallization and functionality of inorganic materials. On the basis of the chemical bonding theory of single crystal growth, we can quantitatively simulate Cu{sub 2}O crystallization processes in solution system. We also kinetically controlled Cu{sub 2}O crystallization process in the reduction solution route. Lithium ion battery and supercapacitor performances of some oxides such as Co{sub 3}O{sub 4} and MnO{sub 2} were shown to elucidate the important effect of crystallization on functionality of inorganic materials. This work encourages us to create novel functionalities through the study of crystallization of inorganic materials, which warrants more chances in the field of functional materials.

  6. 6.20 Mapping Human Brain Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 612011 6.20 Mapping Human Brain Function Many mysteries of the human brain have been unraveled by positron emission tomography (PET), an imaging tool used worldwide to diagnose ...

  7. Critical Assessment of Function Annotation Meeting, 2011

    SciTech Connect (OSTI)

    Friedberg, Iddo

    2015-01-21

    The Critical Assessment of Function Annotation meeting was held July 14-15, 2011 at the Austria Conference Center in Vienna, Austria. There were 73 registered delegates at the meeting. We thank the DOE for this award. It helped us organize and support a scientific meeting AFP 2011 as a special interest group (SIG) meeting associated with the ISMB 2011 conference. The conference was held in Vienna, Austria, in July 2011. The AFP SIG was held on July 15-16, 2011 (immediately preceding the conference). The meeting consisted of two components, the first being a series of talks (invited and contributed) and discussion sections dedicated to protein function research, with an emphasis on the theory and practice of computational methods utilized in functional annotation. The second component provided a large-scale assessment of computational methods through participation in the Critical Assessment of Functional Annotation (CAFA).

  8. Physicochemically functional ultrathin films by interfacial polymerization

    DOE Patents [OSTI]

    Lonsdale, H.K.; Babcock, W.C.; Friensen, D.T.; Smith, K.L.; Johnson, B.M.; Wamser, C.C.

    1990-08-14

    Interfacially-polymerized ultrathin films containing physicochemically functional groups are disclosed, both with and without supports. Various applications are disclosed, including membrane electrodes, selective membranes and sorbents, biocompatible materials, targeted drug delivery, and narrow band optical absorbers. 3 figs.

  9. Safety Management Functions, Responsibilities, and Authorities Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1997-10-08

    This Manual defines safety management functions, responsibilities, and authorities for DOE senior management with responsibilities for line, support, oversight, and enforcement actions. Canceled by DOE M 411.1-1A. Does not cancel other directives.

  10. Functionalized Polyacrylamide Monolith for Rapid Bacteria Pathogen

    Office of Scientific and Technical Information (OSTI)

    Detection in Human Blood. (Conference) | SciTech Connect Conference: Functionalized Polyacrylamide Monolith for Rapid Bacteria Pathogen Detection in Human Blood. Citation Details In-Document Search Title: Functionalized Polyacrylamide Monolith for Rapid Bacteria Pathogen Detection in Human Blood. Abstract not provided. Authors: Mai, Junyu ; Piccini, Matthew Ernest ; Hatch, Anson V. ; Abhyankar, Vinay V. ; Olano, Juan ; Willson, Richard Publication Date: 2014-01-01 OSTI Identifier: 1140705

  11. Translocator Protein Structure and Function | Stanford Synchrotron

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radiation Lightsource Translocator Protein Structure and Function Monday, November 30, 2015 Translocator protein (TSPO) is an ancient conserved protein whose functions in bacteria and higher eukaryotes are yet to be clearly defined in spite of more than 30 years of study. In mitochondria, it was first recognized as an outer membrane protein that binds benzodiazepine drugs, but distinct from the central nervous system site, the GABAA receptor(1). Originally called the peripheral

  12. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Peptoid Nanosheets Offer a Diversity of Functionalities Print Wednesday, 29 April 2015 00:00 Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to

  13. Extraction of Transversity and Collins Functions

    SciTech Connect (OSTI)

    Anselmino, Mauro; Boglione, Mariaelena; D'Alesio, Umberto; Melis, Stefano; Murgia, Francesco; Prokudin, Alexei

    2014-01-01

    We present a global re-analysis of recent experimental data on azimuthal asymmetries in semi-inclusive deep inelastic scattering, from the HERMES and COMPASS Collaborations, and in e{sup +}e{sup -} --> h_1h_2X processes, from the Belle Collaboration. The transversity distribution and the Collins functions are extracted simultaneously, in a revised analysis which also takes into account a new parameterization of the unknown functions.

  14. Density-dependent covariant energy density functionals

    SciTech Connect (OSTI)

    Lalazissis, G. A.

    2012-10-20

    Relativistic nuclear energy density functionals are applied to the description of a variety of nuclear structure phenomena at and away fromstability line. Isoscalar monopole, isovector dipole and isoscalar quadrupole giant resonances are calculated using fully self-consistent relativistic quasiparticle randomphase approximation, based on the relativistic Hartree-Bogoliubovmodel. The impact of pairing correlations on the fission barriers in heavy and superheavy nuclei is examined. The role of pion in constructing desnity functionals is also investigated.

  15. The geometry of electron wave functions

    SciTech Connect (OSTI)

    Aminov, Yurii A

    2013-02-28

    To each wave function we assign a codimension-two submanifold in Euclidean space. We study the case of the wave function of a single electron in the hydrogen atom or other hydrogen-type atoms with quantum numbers n, l, m in detail. We prove theorems describing the behaviour of the scalar and sectional curvature of the constructed submanifold, depending on the quantum numbers. We also consider the external geometry of the submanifold. Bibliography: 9 titles.

  16. Electroweak fragmentation functions for dark matter annihilation

    SciTech Connect (OSTI)

    Cavasonza, Leila Ali; Krämer, Michael; Pellen, Mathieu

    2015-02-18

    Electroweak corrections can play a crucial role in dark matter annihilation. The emission of gauge bosons, in particular, leads to a secondary flux consisting of all Standard Model particles, and may be described by electroweak fragmentation functions. To assess the quality of the fragmentation function approximation to electroweak radiation in dark matter annihilation, we have calculated the flux of secondary particles from gauge-boson emission in models with Majorana fermion and vector dark matter, respectively. For both models, we have compared cross sections and energy spectra of positrons and antiprotons after propagation through the galactic halo in the fragmentation function approximation and in the full calculation. Fragmentation functions fail to describe the particle fluxes in the case of Majorana fermion annihilation into light fermions: the helicity suppression of the lowest-order cross section in such models cannot be lifted by the leading logarithmic contributions included in the fragmentation function approach. However, for other classes of models like vector dark matter, where the lowest-order cross section is not suppressed, electroweak fragmentation functions provide a simple, model-independent and accurate description of secondary particle fluxes.

  17. Structural and functional studies of conserved nucleotide-binding protein LptB in lipopolysaccharide transport

    SciTech Connect (OSTI)

    Wang, Zhongshan; Xiang, Quanju; Zhu, Xiaofeng; Dong, Haohao; He, Chuan; Wang, Haiyan; Zhang, Yizheng; Wang, Wenjian; Dong, Changjiang

    2014-09-26

    Highlights: • Determination of the structure of the wild-type LptB in complex with ATP and Mg{sup 2+}. • Demonstrated that ATP binding residues are essential for LptB’s ATPase activity and LPS transport. • Dimerization is required for the LptB’s function and LPS transport. • Revealed relationship between activity of the LptB and the vitality of E. coli cells. - Abstract: Lipopolysaccharide (LPS) is the main component of the outer membrane of Gram-negative bacteria, which plays an essential role in protecting the bacteria from harsh conditions and antibiotics. LPS molecules are transported from the inner membrane to the outer membrane by seven LPS transport proteins. LptB is vital in hydrolyzing ATP to provide energy for LPS transport, however this mechanism is not very clear. Here we report wild-type LptB crystal structure in complex with ATP and Mg{sup 2+}, which reveals that its structure is conserved with other nucleotide-binding proteins (NBD). Structural, functional and electron microscopic studies demonstrated that the ATP binding residues, including K42 and T43, are crucial for LptB’s ATPase activity, LPS transport and the vitality of Escherichia coli cells with the exceptions of H195A and Q85A; the H195A mutation does not lower its ATPase activity but impairs LPS transport, and Q85A does not alter ATPase activity but causes cell death. Our data also suggest that two protomers of LptB have to work together for ATP hydrolysis and LPS transport. These results have significant impacts in understanding the LPS transport mechanism and developing new antibiotics.

  18. GeoChips for Analysis of Microbial Functional Communities (Book...

    Office of Scientific and Technical Information (OSTI)

    that contain probes for genes encoding proteins or enzymes involved in functions of ... GENES; HYBRIDIZATION; PROBES; PROTEINS; WASHING Microbial Functional ...

  19. When Function Follows Form: Plastic Solar Cells | ANSER Center...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    When Function Follows Form: Plastic Solar Cells Home > Research > ANSER Research Highlights > When Function Follows Form: Plastic Solar Cells...

  20. Essential roles of protein-solvent many-body correlation in solvent-entropy effect on protein folding and denaturation: Comparison between hard-sphere solvent and water

    SciTech Connect (OSTI)

    Oshima, Hiraku; Kinoshita, Masahiro

    2015-04-14

    In earlier works, we showed that the entropic effect originating from the translational displacement of water molecules plays the pivotal role in protein folding and denaturation. The two different solvent models, hard-sphere solvent and model water, were employed in theoretical methods wherein the entropic effect was treated as an essential factor. However, there were similarities and differences in the results obtained from the two solvent models. In the present work, to unveil the physical origins of the similarities and differences, we simultaneously consider structural transition, cold denaturation, and pressure denaturation for the same protein by employing the two solvent models and considering three different thermodynamic states for each solvent model. The solvent-entropy change upon protein folding/unfolding is decomposed into the protein-solvent pair (PA) and many-body (MB) correlation components using the integral equation theories. Each component is further decomposed into the excluded-volume (EV) and solvent-accessible surface (SAS) terms by applying the morphometric approach. The four physically insightful constituents, (PA, EV), (PA, SAS), (MB, EV), and (MB, SAS), are thus obtained. Moreover, (MB, SAS) is discussed by dividing it into two factors. This all-inclusive investigation leads to the following results: (1) the protein-water many-body correlation always plays critical roles in a variety of folding/unfolding processes; (2) the hard-sphere solvent model fails when it does not correctly reproduce the protein-water many-body correlation; (3) the hard-sphere solvent model becomes problematic when the dependence of the many-body correlation on the solvent number density and temperature is essential: it is not quite suited to studies on cold and pressure denaturating of a protein; (4) when the temperature and solvent number density are limited to the ambient values, the hard-sphere solvent model is usually successful; and (5) even at the ambient values, however, the many-body correlation plays significant roles in the β-sheet formation and argument of relative stabilities of very similar structures of a protein. These results are argued in detail with respect to the four physically insightful constituents and the two factors mentioned above. The relevance to the absence or presence of hydrogen-bonding properties in the solvent is also discussed in detail.

  1. Functionalization of polymer powders for SLS-processes using an atmospheric plasma jet in a fluidized bed reactor

    SciTech Connect (OSTI)

    Sachs, Marius; Schmitt, Adeliene; Schmidt, Jochen; Peukert, Wolfgang; Wirth, Karl-Ernst

    2015-05-22

    Recently additive manufacturing processes such as selective laser sintering (SLS) of polymers have gained more importance for industrial applications [1]. Tailor-made modification of polymers is essential in order to make these processes more efficient and to cover the industrial demands. The so far used polymer materials show weak performance regarding the mechanical stability of processed parts. To overcome this limitation, a new route to functionalize the surface of commercially available polymer particles (PA12; PE-HD; PP) using an atmospheric plasma jet in combination with a fluidized bed reactor has been investigated. Consequently, an improvement of adhesion and wettability [2] of the polymer surface without restraining the bulk properties of the powder is achieved. The atmospheric plasma jet process can provide reactive species at moderate temperatures which are suitable for polymer material. The functionalization of the polymer powders improves the quality of the devices build in a SLS-process.

  2. Tiny plastic lung mimics human pulmonary function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tiny plastic lung mimics human pulmonary function Tiny plastic lung mimics human pulmonary function Scientists are developing a miniature, tissue-engineered artificial lung that mimics the response of the human lung to drugs, toxins and other agents. April 25, 2016 The full PuLMo artificial lung system in operation. The full PuLMo artificial lung system in operation. Contact Kevin Roark Communications Office (505) 665-9202 Email "When we build our lung, we not only take into account the

  3. HTGR Industrial Application Functional and Operational Requirements

    SciTech Connect (OSTI)

    L. E. Demick

    2010-08-01

    This document specifies the functional and performance requirements to be used in the development of the conceptual design of a high temperature gas-cooled reactor (HTGR) based plant supplying energy to a typical industrial facility. These requirements were developed from collaboration with industry and HTGR suppliers over the preceding three years to identify the energy needs of industrial processes for which the HTGR technology is technically and economically viable. The functional and performance requirements specified herein are an effective representation of the industrial sector energy needs and an effective basis for developing a conceptual design of the plant that will serve the broadest range of industrial applications.

  4. Method of making low work function component

    DOE Patents [OSTI]

    Robinson, Vance (Niskayuna, NY); Weaver, Stanton Earl (Northville, NY); Michael, Joseph Darryl (Delmar, NY)

    2011-11-15

    A method for fabricating a component is disclosed. The method includes: providing a member having an effective work function of an initial value, disposing a sacrificial layer on a surface of the member, disposing a first agent within the member to obtain a predetermined concentration of the agent at said surface of the member, annealing the member, and removing the sacrificial layer to expose said surface of the member, wherein said surface has a post-process effective work function that is different from the initial value.

  5. Optically transparent and environmentally durable superhydrophobic coating based on functionalized SiO2 nanoparticles

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Schaeffer, Daniel A; Polyzos, Georgios; Smith, Barton Barton; Lee, Dominic F; Hunter, Scott Robert; Datskos, Panos G

    2015-01-01

    Optical surfaces such as mirrors and windows that are exposed to outdoor environmental conditions are susceptible to dust buildup and water condensation. The application of transparent superhydrophobic coatings on optical surfaces can improve outdoor performance via a self-cleaning effect similar to the Lotus effect. The contact angle (CA) of water droplets on a typical hydrophobic flat surface varies from 100 to 120 . Adding roughness or microtexture to a hydrophobic surface leads to an enhancement of hydrophobicity and the CA can be increased to a value in the range of 160 to 175 . This result is remarkable because suchmore » behavior cannot be explained using surface chemistry alone. When surface features are on the order of 100 nm or smaller, surfaces exhibit superhydrophobic behavior and maintain their optical transparency. In this work we discuss our results on transparent superhydrophobic coatings that can be applied across large surface areas. We have used functionalized silica nanoparticles to coat various optical elements and have measured the contact angle and optical transmission between 190 to 1100 nm on these elements. The functionalized silica nanoparticles were dissolved in a solution of the solvents isopropyl alcohol and 4-chlorobenzotrifluoride (PCBTF) and a proprietary ceramic binder (Cerakote ). This solution was spin-coated onto a variety of test glass substrates, and following a curing period of about 30 minutes, these coatings exhibited superhydrophobic behavior with a static CA 160 .« less

  6. Photon structure function at small x

    SciTech Connect (OSTI)

    Gluck, M.; Reya, E.; Schienbein, I.

    2001-07-01

    It is shown that recent small-x measurements of the photon structure function F{sub 2}{sup {gamma}}(x,Q{sup 2}) by the CERN LEP OPAL Collaboration are consistent with parameter-free QCD predictions at all presently accessible values of Q{sup 2}.

  7. Safety Management Functions, Responsibilities, and Authorities Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-10-18

    This Manual is a mechanism for implementing the Department's guiding principles established in DOE P 450.4 and the safety management functions outlined in DOE P 411.1 Cancels DOE M 411.1-1. Canceled by DOE M 411.1-1B.

  8. Poly(ethyleneoxide) functionalization through alkylation

    DOE Patents [OSTI]

    Sivanandan, Kulandaivelu; Eitouni, Hany Basam; Li, Yan; Pratt, Russell Clayton

    2015-04-21

    A new and efficient method of functionalizing high molecular weight polymers through alkylation using a metal amide base is described. This novel procedure can also be used to synthesize polymer-based macro-initiators containing radical initiating groups at the chain-ends for synthesis of block copolymers.

  9. Aviation Safety Officer, Functional Area Qualification Standard

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2010-01-20

    The Aviation Safety Officer FAQS establishes common functional area competency requirements for all DOE aviation safety personnel who provide assistance, or direction, guidance, oversight, or evaluation of contractor technical activities that could impact the safe operation of DOE’s facilities.

  10. Aviation Manager Functional Area Qualification Standard

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-12-09

    The Aviation Manager FAQS establishes common functional area competency requirements for all DOE Aviation Manager personnel who provide assistance, direction, guidance, oversight, or evaluation of contractor technical activities that could impact the safe operation of DOE’s defense nuclear facilities.

  11. Controlling Atomic Layer Deposition of TiO2 in Aerogels through Surface Functionalization

    SciTech Connect (OSTI)

    Ghosal, S; Baumann, T F; King, J S; Kucheyev, S; Wang, Y; Worsley, M A; Biener, J; Bent, S F; Hamza, A V

    2009-03-09

    This report demonstrates a chemical functionalization method for controlling atomic layer deposition (ALD) of TiO{sub 2} in low-density nanoporous materials. Functionalization of silica aerogel with trimethylsilane is shown to strongly suppress TiO{sub 2} growth via ALD. Subsequent modification of the functionalization through selective removal of the hydrocarbon groups reactivates the aerogel towards TiO{sub 2} deposition. These results demonstrate the potential use of ALD as a selective tool for creating novel nanoporous materials. Nanoporous materials present significant technological advantage for a wide range of applications, including catalysis, energy storage and conversion, nanoelectronics to name just a few (1-4). Hence, there is considerable interest in developing synthetic pathways for the fabrication of nanoporous materials with tailored properties. Aerogels (AGs) are unique low-density, open-cell porous materials consisting of submicrometer pores and ligaments that can be used as a robust material platform for designing novel nanoporous materials. In recent years, a synthetic approach based on ALD on AG templates has emerged as a promising method for the directed growth of nanoporous materials (5-11, 18). This approach has been used successfully to prepare millimeter-sized high aspect ratio aerogels coated uniformly with zinc oxide (ZnO), tungsten (W) and alumina (Al{sub 2}O{sub 3}) (10, 11). The ALD process utilizes two sequential, self-limiting surface reactions resulting in a layer-by-layer growth mode. The self limiting nature of the surface reactions makes ALD a particularly suitable technique for uniform deposition onto high aspect ratio porous substrates. Additionally, chemical specificity of the surface reactions in ALD enables one to control the deposition process through selective functionalization of the substrate surface. In fact the functionalization of planar substrates such as silicon wafers with organosilane groups (R{sub n}SiX{sub 4-n} (n = 1-3)) has been shown to deactivate the substrate towards ZrO{sub 2}, HfO{sub 2}, ZnO, and TiO{sub 2} ALD processes (12-16). A possible mechanism for the deactivation effect is the blocking of surface functional groups, such as hydroxyl (OH) moieties, which serve as chemisorption sites for the ALD precursors and hence are essential for nucleating the deposition process. Henceforth, we shall refer to these surface functional groups as nucleation sites for the ALD process.

  12. Measurement of the neutron F2 structure function via spectator tagging with CLAS

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Baillie, N.; Tkachenko, S.; Zhang, J.; Bosted, P.; Bültmann, S.; Christy, M. E.; Fenker, H.; Griffioen, K. A.; Keppel, C. E.; Kuhn, S. E.; et al

    2012-04-01

    We report on the first measurement of the F2 structure function of the neutron from semi-inclusive scattering of electrons from deuterium, with low-momentum protons detected in the backward hemisphere. Restricting the momentum of the spectator protons to ≈< 100 MeV and their angles to ≈> 100 degrees relative to the momentum transfer allows an interpretation of the process in terms of scattering from nearly on-shell neutrons. The F2n data collected cover the nucleon resonance and deep-inelastic regions over a wide range of x for 0.65 < Q2 < 4.52 GeV2, with uncertainties from nuclear corrections estimated to be less thanmore » a few percent. These measurements provide the first determination of the neutron to proton structure function ratio F2n/F2p at 0.2 ≈< x ≈< 0.8, essentially free of nuclear corrections.« less

  13. Structure-function analysis of human protein Ero1-L{alpha}

    SciTech Connect (OSTI)

    Chu, Yanyan [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China)] [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); Yang, Charles; Chen, Xianjun; Zheng, Wenyun [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China) [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); Yang, Yi, E-mail: yiyang@ecust.edu.cn [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China) [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China); Tang, Yun, E-mail: ytang234@ecust.edu.cn [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China)] [Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China)

    2009-11-27

    Human Ero1-L{alpha} catalyzes the formation of disulfide bond and hence plays an essential role in protein folding. Understanding the mechanism of disulfide bond formation in mammals is important because of the involvement of protein misfolding in conditions such as diabetes, arthritis, cancer, and aging. However, the crystal structure of the enzyme is not available yet, which seriously hinders the understanding of biological function of Ero1-L{alpha}. Based on the crystal structure of yeast Ero1p, a rational three-dimensional structural model of Ero1-L{alpha} was built and the characteristics of the enzyme were hence investigated. The characteristic similarities and differences between Ero1-L{alpha} and Ero1p were compared on the basis of computational and experimental results, providing the first insight into the structure-function relationships of the enzymes. Both calculation and experiment got the concordant conclusion that FAD binds more tightly with Ero1-L{alpha} than Ero1p. In addition, the probable electron transfer pathway was proposed on the basis of the structural models.

  14. Measurement of the neutron F2 structure function via spectator tagging with CLAS

    SciTech Connect (OSTI)

    Baillie, N.; Tkachenko, S.; Zhang, J.; Bosted, P.; Bltmann, S.; Christy, M. E.; Fenker, H.; Griffioen, K. A.; Keppel, C. E.; Kuhn, S. E.; Melnitchouk, W.; Tvaskis, V.; Adhikari, K. P.; Adikaram, D.; Aghasyan, M.; Amaryan, M. J.; Anghinolfi, M.; Arrington, J.; Avakian, H.; Baghdasaryan, H.; Battaglieri, M.; Biselli, A. S.; Branford, D.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Cole, P. L.; Contalbrigo, M.; Crede, V.; DAngelo, A.; Daniel, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Deur, A.; Dey, B.; Djalali, C.; Dodge, G.; Domingo, J.; Doughty, D.; Dupre, R.; Dutta, D.; Ent, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Fradi, A.; Gabrielyan, M. Y.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Graham, L.; Guegan, B.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Heddle, D.; Hicks, K.; Holtrop, M.; Hungerford, E.; Hyde, C. E.; Ilieva, Y.; Ireland, D. G.; Ispiryan, M.; Isupov, E. L.; Jawalkar, S. S.; Jo, H. S.; Kalantarians, N.; Khandaker, M.; Khetarpal, P.; Kim, A.; Kim, W.; King, P. M.; Klein, A.; Klein, F. J.; Klimenko, A.; Kubarovsky, V.; Kuleshov, S. V.; Kvaltine, N. D.; Livingston, K.; Lu, H. Y.; MacGregor, I. J. D.; Mao, Y.; Markov, N.; McKinnon, B.; Mineeva, T.; Morrison, B.; Moutarde, H.; Munevar, E.; Nadel-Turonski, P.; Ni, A.; Niccolai, S.; Niculescu, I.; Niculescu, G.; Osipenko, M.; Ostrovidov, A. I.; Pappalardo, L.; Park, K.; Park, S.; Pasyuk, E.; Anefalos Pereira, S.; Pisano, S.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Prok, Y.; Protopopescu, D.; Raue, B. A.; Ricco, G.; Rimal, D.; Ripani, M.; Rosner, G.; Rossi, P.; Sabati, F.; Saini, M. S.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seder, E.; Sharabian, Y. G.; Sober, D. I.; Sokhan, D.; Stepanyan, S.; Stepanyan, S. S.; Stoler, P.; Strauch, S.; Taiuti, M.; Tang, W.; Ungaro, M.; Vineyard, M. F.; Voutier, E.; Watts, D. P.; Weinstein, L. B.; Weygand, D. P.; Wood, M. H.; Zana, L.; Zhao, B.

    2012-04-01

    We report on the first measurement of the F2 structure function of the neutron from semi-inclusive scattering of electrons from deuterium, with low-momentum protons detected in the backward hemisphere. Restricting the momentum of the spectator protons to ?< 100 MeV and their angles to ?> 100 degrees relative to the momentum transfer allows an interpretation of the process in terms of scattering from nearly on-shell neutrons. The F2n data collected cover the nucleon resonance and deep-inelastic regions over a wide range of x for 0.65 < Q2 < 4.52 GeV2, with uncertainties from nuclear corrections estimated to be less than a few percent. These measurements provide the first determination of the neutron to proton structure function ratio F2n/F2p at 0.2 ?< x ?< 0.8, essentially free of nuclear corrections.

  15. Remote sensing-based characterization, 2-m, Plant Functional Type Distributions, Barrow Environmental Observatory, 2010

    SciTech Connect (OSTI)

    Zachary Langford; Forrest Hoffman; Jitendra Kumar

    2014-01-01

    Arctic ecosystems have been observed to be warming faster than the global average and are predicted to experience accelerated changes in climate due to global warming. Arctic vegetation is particularly sensitive to warming conditions and likely to exhibit shifts in species composition, phenology and productivity under changing climate. Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral characteristics which can be harnessed to discriminate plant types and develop quantitative vegetation indices. We have combined high resolution multi-spectral remote sensing from the WorldView 2 satellite with LIDAR-derived digital elevation models to characterize the tundra landscape on the North Slope of Alaska. Classification of landscape using spectral and topographic characteristics yields spatial regions with expectedly similar vegetation characteristics. A field campaign was conducted during peak growing season to collect vegetation harvests from a number of 1m x 1m plots in the study region, which were then analyzed for distribution of vegetation types in the plots. Statistical relationships were developed between spectral and topographic characteristics and vegetation type distributions at the vegetation plots. These derived relationships were employed to statistically upscale the vegetation distributions for the landscape based on spectral characteristics. Vegetation distributions developed are being used to provide Plant Functional Type (PFT) maps for use in the Community Land Model (CLM).

  16. Remote sensing-based characterization, 2-m, Plant Functional Type Distributions, Barrow Environmental Observatory, 2010

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Zachary Langford; Forrest Hoffman; Jitendra Kumar

    Arctic ecosystems have been observed to be warming faster than the global average and are predicted to experience accelerated changes in climate due to global warming. Arctic vegetation is particularly sensitive to warming conditions and likely to exhibit shifts in species composition, phenology and productivity under changing climate. Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral characteristics which can be harnessed to discriminate plant types and develop quantitative vegetation indices. We have combined high resolution multi-spectral remote sensing from the WorldView 2 satellite with LIDAR-derived digital elevation models to characterize the tundra landscape on the North Slope of Alaska. Classification of landscape using spectral and topographic characteristics yields spatial regions with expectedly similar vegetation characteristics. A field campaign was conducted during peak growing season to collect vegetation harvests from a number of 1m x 1m plots in the study region, which were then analyzed for distribution of vegetation types in the plots. Statistical relationships were developed between spectral and topographic characteristics and vegetation type distributions at the vegetation plots. These derived relationships were employed to statistically upscale the vegetation distributions for the landscape based on spectral characteristics. Vegetation distributions developed are being used to provide Plant Functional Type (PFT) maps for use in the Community Land Model (CLM).

  17. Remote sensing-based characterization of plant functional type distributions at the Barrow Environmental Observatory

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kumar, Jitendra; Hoffman, Forrest M.

    Arctic ecosystems have been observed to be warming faster than the global average and are predicted to experience accelerated changes in climate due to global warming. Arctic vegetation is particularly sensitive to warming conditions and likely to exhibit shifts in species composition, phenology and productivity under changing climate. Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral characteristics which can be harnessed to discriminate plant types and develop quantitative vegetation indices. We have combined high resolution multi-spectral remote sensing from the WorldView 2 satellite with LIDAR-derived digital elevation models to characterize the tundra landscape on the North Slope of Alaska. Classification of landscape using spectral and topographic characteristics yields spatial regions with expectedly similar vegetation characteristics. A field campaign was conducted during peak growing season to collect vegetation harvests from a number of 1m x 1m plots in the study region, which were then analyzed for distribution of vegetation types in the plots. Statistical relationships were developed between spectral and topographic characteristics and vegetation type distributions at the vegetation plots. These derived relationships were employed to statistically upscale the vegetation distributions for the landscape based on spectral characteristics. Vegetation distributions developed are being used to provide Plant Functional Type (PFT) maps for use in the Community Land Model (CLM).

  18. Remote sensing-based characterization of plant functional type distributions at the Barrow Environmental Observatory

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kumar, Jitendra; Hoffman, Forrest M.

    2014-03-18

    Arctic ecosystems have been observed to be warming faster than the global average and are predicted to experience accelerated changes in climate due to global warming. Arctic vegetation is particularly sensitive to warming conditions and likely to exhibit shifts in species composition, phenology and productivity under changing climate. Mapping and monitoring of changes in vegetation is essential to understand the effect of climate change on the ecosystem functions. Vegetation exhibits unique spectral characteristics which can be harnessed to discriminate plant types and develop quantitative vegetation indices. We have combined high resolution multi-spectral remote sensing from the WorldView 2 satellite with LIDAR-derived digital elevation models to characterize the tundra landscape on the North Slope of Alaska. Classification of landscape using spectral and topographic characteristics yields spatial regions with expectedly similar vegetation characteristics. A field campaign was conducted during peak growing season to collect vegetation harvests from a number of 1m x 1m plots in the study region, which were then analyzed for distribution of vegetation types in the plots. Statistical relationships were developed between spectral and topographic characteristics and vegetation type distributions at the vegetation plots. These derived relationships were employed to statistically upscale the vegetation distributions for the landscape based on spectral characteristics. Vegetation distributions developed are being used to provide Plant Functional Type (PFT) maps for use in the Community Land Model (CLM).

  19. Bidirectional reflection functions from surface bump maps

    SciTech Connect (OSTI)

    Cabral, B.; Max, N.; Springmeyer, R.

    1987-04-29

    The Torrance-Sparrow model for calculating bidirectional reflection functions contains a geometrical attenuation factor to account for shadowing and occlusions in a hypothetical distribution of grooves on a rough surface. Using an efficient table-based method for determining the shadows and occlusions, we calculate the geometric attenuation factor for surfaces defined by a specific table of bump heights. Diffuse and glossy specular reflection of the environment can be handled in a unified manner by using an integral of the bidirectional reflection function times the environmental illumination, over the hemisphere of solid angle above a surface. We present a method of estimating the integral, by expanding the bidirectional reflection coefficient in spherical harmonics, and show how the coefficients in this expansion can be determined efficiently by reorganizing our geometric attenuation calculation.

  20. Multiple soft limits of cosmological correlation functions

    SciTech Connect (OSTI)

    Joyce, Austin; Khoury, Justin; Simonovi?, Marko E-mail: jkhoury@sas.upenn.edu

    2015-01-01

    We derive novel identities satisfied by inflationary correlation functions in the limit where two external momenta are taken to be small. We derive these statements in two ways: using background-wave arguments and as Ward identities following from the fixed-time path integral. Interestingly, these identities allow us to constrain some of the O(q{sup 2}) components of the soft limit, in contrast to their single-soft analogues. We provide several nontrivial checks of our identities both in the context of resonant non-Gaussianities and in small sound speed models. Additionally, we extend the relation at lowest order in external momenta to arbitrarily many soft legs, and comment on the many-soft extension at higher orders in the soft momentum. Finally, we consider how higher soft limits lead to identities satisfied by correlation functions in large-scale structure.

  1. Infrared photoemitting diode having reduced work function

    DOE Patents [OSTI]

    Hirschfeld, Tomas B. (Livermore, CA)

    1984-01-01

    In electro-optical detectors which include as elements a photoemitting photocathode and anode, a photoemitting diode is fabricated which lowers the diode's work function, thus reducing the cooling requirement typically needed for this type of device. The work function is reduced by sandwiching between the photocathode and anode a liquid medium of the formula NR.sub.3 and having an electron affinity for the electrons of the photocathode, which liquid medium permits free electrons leaving the photocathode to remain as stable solvated species in the liquid medium. Thus, highly light-absorbent, and therefore thin, metallic layers can be used for detection, thereby reducing dark current at a given temperature, with a consequent reduction in cooling requirements at constant detector performance.

  2. Infrared photoemitting diode having reduced work function

    DOE Patents [OSTI]

    Hirschfeld, T.B.

    1982-05-06

    In electro-optical detectors which include as elements a photoemitting photocathode and anode, a photoemitting diode is fabricated which lowers the diode's work function, thus reducing the cooling requirement typically needed for this type of device. The work function is reduced by sandwiching between the photocathode and anode a liquid meidum of the formula NR/sub 3/ and having an electron affinity for the electrons of the photocathode, which liquid medium permits free electrons leaving the photocathode to remain as stable solvated species in the liquid medium. Thus, highly light-absorbent, and therefore thin, metallic layers can be used for detection, thereby reducing dark current at a given temperature, with a consequent reduction in cooling requirements at constant detector performance.

  3. Arterial endothelial function measurement method and apparatus

    DOE Patents [OSTI]

    Maltz, Jonathan S; Budinger, Thomas F

    2014-03-04

    A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.

  4. Functional electrolyte for lithium-ion batteries

    DOE Patents [OSTI]

    Zhang, Lu; Zhang, Zhengcheng; Amine, Khalil

    2015-04-14

    Functional electrolyte solvents include compounds having at least one aromatic ring with 2, 3, 4 or 5 substituents, at least one of which is a substituted or unsubstituted methoxy group, at least one of which is a tert-butyl group and at least one of which is a substituted or unsubstituted polyether or poly(ethylene oxide) (PEO) group bonded through oxygen to the aromatic ring, are provided.

  5. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Print Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to artificial enzymes. Because peptoids are highly designable polymers, nanosheets provide a

  6. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Print Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to artificial enzymes. Because peptoids are highly designable polymers, nanosheets provide a

  7. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Print Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to artificial enzymes. Because peptoids are highly designable polymers, nanosheets provide a

  8. Functional Area Criteria & Review Approach Documents

    Broader source: Energy.gov [DOE]

    CRADS provided on this page are provided as examples of functional area Objectives and Criteria used to evaluate how requirements are meet. They are only examples and should not be utilized as is. In accordance with DOE Standard 3006-2010, CRADs should be developed by team members to reflect the specifics of the proposed review (i.e., breadth and depth) as defined in the approved Plan of Action.

  9. Instrumentation and Control Functional Area Qualification Standard

    Energy Savers [EERE]

    NOT MEASUREMENT SENSITIVE DOE-STD-1162-2013 June 2013 DOE STANDARD INSTRUMENTATION AND CONTROL FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A: Approved for public release; distribution is unlimited. DOE-STD-1162-2013 This document is available on the Department of Energy Technical Standards Program website at http://www.hss.energy.gov/nuclearsafety/ns/techstds/ ii

  10. Safeguards and Security Functional Area Qualification Standard

    Energy Savers [EERE]

    1-2009 May 2009 DOE STANDARD SAFEGUARDS AND SECURITY FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. DOE-STD-1171-2009 ii This document is available on the Department of Energy Technical Standards Program Web Site at http://www.hss.energy.gov/nuclearsafety/techstds/ DOE-STD-1171-2009 iii APPROVAL The Federal

  11. Redshift distortions of galaxy correlation functions

    SciTech Connect (OSTI)

    Fry, J.N. Florida Univ., Gainesville, FL . Dept. of Physics); Gaztanaga, E. Oxford Univ. . Dept. of Physics)

    1993-05-12

    To examine how peculiar velocities can affect the 2-, 3-, and 4-point correlation functions, we evaluate volume-average correlations for configurations that emphasize and minimize distortions for four different volume-limited samples from each of the CfA, SSRS, and IRAS redshift catalogs. We present the results as the correlation length r[sub 0] and power index [gamma] of the 2-point correlation, [anti [Xi

  12. Facility Representative Functional Area Qualification Standard

    Energy Savers [EERE]

    DOE-STD-1151-2010 October 2010 DOE STANDARD FACILITY REPRESENTATIVE FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. DOE-STD-1151-2010 ii This document is available on the Department of Energy Office of Health, Safety and Security Approved DOE Technical Standards Web Site at

  13. Fire Protection Engineering Functional Area Qualification Standard

    Energy Savers [EERE]

    37-2014 April 2014 _______________________________ Supersedes DOE-STD-1137-2007 September 2007 DOE STANDARD FIRE PROTECTION ENGINEERING FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical Personnel U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A: Approved for public release; distribution is unlimited. DOE-STD-1137-2014 ii This document is available on the Department of Energy Technical Standards Program Website at

  14. Peptoid Nanosheets Offer a Diversity of Functionalities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Peptoid Nanosheets Offer a Diversity of Functionalities Print Researchers at the ALS have recently observed peptoid nanosheets-two-dimensional biomimetic materials with customizable properties-as they self-assemble at an oil-water interface. These nanosheets are an emerging class of two-dimensional nanomaterials that have the potential for use in a variety of applications ranging from molecular sensors to artificial enzymes. Because peptoids are highly designable polymers, nanosheets provide a

  15. The Full Function Test Explosive Generator

    SciTech Connect (OSTI)

    Reisman, D B; Javedani, J B; Griffith, L V; Ellsworth, G F; Kuklo, R M; Goerz, D A; White, A D; Tallerico, L J; Gidding, D A; Murphy, M J; Chase, J B

    2009-12-13

    We have conducted three tests of a new pulsed power device called the Full Function Test (FFT). These tests represented the culmination of an effort to establish a high energy pulsed power capability based on high explosive pulsed power (HEPP) technology. This involved an extensive computational modeling, engineering, fabrication, and fielding effort. The experiments were highly successful and a new US record for magnetic energy was obtained.

  16. Emergency Support Function #12; Energy Annex

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Emergency Support Function #12 - Energy Annex January 2008 ESF #12 - Energy Annex ESF #12-1 ESF Coordinator: Department of Energy Primary Agency: Department of Energy Support Agencies: Department of Agriculture Department of Commerce Department of Defense Department of Homeland Security Department of the Interior Department of Labor Department of State Department of Transportation Environmental Protection Agency Nuclear Regulatory Commission Tennessee Valley Authority INTRODUCTION Purpose

  17. Sexual Function After Stereotactic Body Radiotherapy for Prostate Cancer: Results of a Prospective Clinical Trial

    SciTech Connect (OSTI)

    Wiegner, Ellen A. [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA (United States); King, Christopher R., E-mail: crking@stanford.ed [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA (United States)

    2010-10-01

    Purpose: To study the sexual quality of life for prostate cancer patients after stereotactic body radiotherapy (SBRT). Methods and Materials: Using the Expanded Prostate Cancer Index Composite (EPIC)-validated quality-of-life questionnaire, the sexual function of 32 consecutive patients who received prostate SBRT in a prospective Phase II clinical trial were analyzed at baseline, and at median times of 4, 12, 20, and 50 months after treatment. SBRT consisted of 36.25 Gy in five fractions of 7.25 Gy using the Cyberknife. No androgen deprivation therapy was given. The use of erectile dysfunction (ED) medications was monitored. A comprehensive literature review for radiotherapy-alone modalities based on patient self-reported questionnaires served as historical comparison. Results: Median age at treatment was 67.5 years, and median follow-up was 35.5 months (minimum 12 months). The mean EPIC sexual domain summary score, sexual function score, and sexual bother score decreased by 45%, 49%, and 25% respectively at 50 months follow-up. These differences reached clinical relevance by 20 months after treatment. Baseline ED rate was 38% and increased to 71% after treatment (p = 0.024). Use of ED medications was 3% at baseline and progressed to 25%. For patients aged <70 years at follow-up, 60% maintained satisfactory erectile function after treatment compared with only 12% aged {>=}70 years (p = 0.008). Penile bulb dose was not associated with ED. Conclusions: The rates of ED after treatment appear comparable to those reported for other modalities of radiotherapy. Given the modest size of this study and the uncertainties in the physiology of radiotherapy-related ED, these results merit further investigations.

  18. Combined photonics and MEMs function demonstration

    SciTech Connect (OSTI)

    Blum, O.; Warren, M.E.; Hou, H.Q.; Choquette, K.D.; Rogers, M.S.; Sniegowski, J.J. [Sandia National Labs., Albuquerque, NM (United States); Carson, R.F. [Microoptical Devices, Inc., Albuquerque, NM (United States)

    1998-01-01

    The authors have recently demonstrated two prototypes where photonics and microelectromechanical system (MEMs) technologies have been integrated to show proof-of-principle functionality for weapon surety functions. These activities are part of a program which is exploring the miniaturization of electromechanical components for making weapon systems safer. Such miniaturization can lead to a low-cost, small, high-performance ``systems-on-a-chip``, and have many applications ranging from advanced military systems to large-volume commercial markets like automobiles, rf or land-based communications networks and equipment, or commercial electronics. One of the key challenges in realization of the microsystem is integration of several technologies including digital electronics; analog and rf electronics, optoelectronics (light emitting and detecting devices and circuits), sensors and actuators, and advanced packaging technologies. In this work the authors describe efforts in integrating MEMs and photonic functions and the fabrication constraints on both system components. Here, they discuss two examples of integration of MEMs and a photonic device. In the first instance, a MEMs locking device pin is driven by a voltage generated by photovoltaic cells connected in series, which are driven by a laser. In the second case, a VCSEL emitting at 1.06 {micro}m is packaged together with a metallized MEMs shutter. By appropriate alignment to the opening in the shutter, the VCSEL is turned on and off by the movement of the Si chopper wheel.

  19. Development of a functionalized Xenon biosensor

    SciTech Connect (OSTI)

    Spence, Megan M.; Ruiz, E. Janette; Rubin, Seth M.; Lowery, Thomas J.; Winssinger, Nicolas; Schultz, Peter G.; Wemmer, David E.; Pines, Alexander

    2004-03-25

    NMR-based biosensors that utilize laser-polarized xenon offer potential advantages beyond current sensing technologies. These advantages include the capacity to simultaneously detect multiple analytes, the applicability to in vivo spectroscopy and imaging, and the possibility of remote amplified detection. Here we present a detailed NMR characterization of the binding of a biotin-derivatized caged-xenon sensor to avidin. Binding of functionalized xenon to avidin leads to a change in the chemical shift of the encapsulated xenon in addition to a broadening of the resonance, both of which serve as NMR markers of ligand-target interaction. A control experiment in which the biotin-binding site of avidin was blocked with native biotin showed no such spectral changes, confirming that only specific binding, rather than nonspecific contact, between avidin and functionalized xenon leads to the effects on the xenon NMR spectrum. The exchange rate of xenon (between solution and cage) and the xenon spin-lattice relaxation rate were not changed significantly upon binding. We describe two methods for enhancing the signal from functionalized xenon by exploiting the laser-polarized xenon magnetization reservoir. We also show that the xenon chemical shifts are distinct for xenon encapsulated in different diastereomeric cage molecules. This demonstrates the potential for tuning the encapsulated xenon chemical shift, which is a key requirement for being able to multiplex the biosensor.

  20. Structure and function of lysosomal ;#8203;phospholipase A2 and...

    Office of Scientific and Technical Information (OSTI)

    function of lysosomal ;8203;phospholipase A2 and ;8203;lecithin:cholesterol acyltransferase Citation Details In-Document Search Title: Structure and function of lysosomal...

  1. Method for the electro-addressable functionalization of electrode...

    Office of Scientific and Technical Information (OSTI)

    Method for the electro-addressable functionalization of electrode arrays Citation Details In-Document Search Title: Method for the electro-addressable functionalization of ...

  2. Molecular functions of the TLE tetramerization domain in Wnt...

    Office of Scientific and Technical Information (OSTI)

    Molecular functions of the TLE tetramerization domain in Wnt target gene repression Citation Details In-Document Search Title: Molecular functions of the TLE tetramerization domain ...

  3. Internal compiler error for function pointer with identically...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Internal compiler error for function pointer with identically named arguments Internal compiler error for function pointer with identically named arguments June 9, 2015 by Scott...

  4. Research Update: Towards designed functionalities in oxide-based...

    Office of Scientific and Technical Information (OSTI)

    Research Update: Towards designed functionalities in oxide-based electronic materials Citation Details In-Document Search Title: Research Update: Towards designed functionalities...

  5. Density Functional Theory Approach to Nuclear Fission (Conference...

    Office of Scientific and Technical Information (OSTI)

    Density Functional Theory Approach to Nuclear Fission Citation Details In-Document Search Title: Density Functional Theory Approach to Nuclear Fission Authors: Schunck, N Publication ...

  6. Pairing Nambu-Goldstone Modes within Nuclear Density Functional...

    Office of Scientific and Technical Information (OSTI)

    Pairing Nambu-Goldstone Modes within Nuclear Density Functional Theory Citation Details ... Title: Pairing Nambu-Goldstone Modes within Nuclear Density Functional Theory Authors: ...

  7. BUILDING A UNIVERSAL NUCLEAR ENERGY DENSITY FUNCTIONAL (UNEDF...

    Office of Scientific and Technical Information (OSTI)

    BUILDING A UNIVERSAL NUCLEAR ENERGY DENSITY FUNCTIONAL (UNEDF) Citation Details In-Document Search Title: BUILDING A UNIVERSAL NUCLEAR ENERGY DENSITY FUNCTIONAL (UNEDF) The ...

  8. Accuracy of density functionals for molecular electronics: The...

    Office of Scientific and Technical Information (OSTI)

    Accuracy of density functionals for molecular electronics: The Anderson junction Title: Accuracy of density functionals for molecular electronics: The Anderson junction Authors: ...

  9. Emergency Support Function #12; Energy Annex - Support Agencies...

    Energy Savers [EERE]

    Annex - Support Agencies Emergency Support Function 12; Energy Annex - Support Agencies Emergency Support Function 12 - Energy Annex - Support Agencies and their related...

  10. Functionality of Commercial NOx Storage-Reduction Catalysts and...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Functionality of Commercial NOx Storage-Reduction Catalysts and the Development of a Representative Model Functionality of Commercial NOx Storage-Reduction Catalysts and the ...

  11. Error Analysis in Nuclear Density Functional Theory (Journal...

    Office of Scientific and Technical Information (OSTI)

    Error Analysis in Nuclear Density Functional Theory Citation Details In-Document Search Title: Error Analysis in Nuclear Density Functional Theory Authors: Schunck, N ; McDonnell,...

  12. Error Analysis in Nuclear Density Functional Theory (Journal...

    Office of Scientific and Technical Information (OSTI)

    Error Analysis in Nuclear Density Functional Theory Citation Details In-Document Search Title: Error Analysis in Nuclear Density Functional Theory You are accessing a document...

  13. Deep Bed Adsorption Testing using Silver-Functionalized Aerogel...

    Office of Scientific and Technical Information (OSTI)

    Deep Bed Adsorption Testing using Silver-Functionalized Aerogel Citation Details In-Document Search Title: Deep Bed Adsorption Testing using Silver-Functionalized Aerogel Nuclear ...

  14. From Protein Structure to Function: Ring Cycle for Dilating and...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    From Protein Structure to Function: Ring Cycle for Dilating and Constricting the Nuclear Pore From Protein Structure to Function: Ring Cycle for Dilating and Constricting the...

  15. ALS Capabilities Reveal Multiple Functions of Ebola Virus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reveal Multiple Functions of Ebola Virus Print A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its function....

  16. Smisc - A collection of miscellaneous functions

    Energy Science and Technology Software Center (OSTI)

    2015-08-31

    A collection of functions for statistical computing and data manipulation. These include routines for rapidly aggregating heterogeneous matrices, manipulating file names, loading R objects, sourcing multiple R files, formatting datetimes, multi-core parallel computing, stream editing, specialized plotting, etc. • Smisc-package A collection of miscellaneous functions allMissing Identifies missing rows or columns in a data frame or matrix as.numericSilent Silent wrapper for coercing a vector to numeric comboList Produces all possible combinations of a set ofmore » linear model predictors cumMax Computes the maximum of the vector up to the current index cumsumNA Computes the cummulative sum of a vector without propogating NAs d2binom Probability functions for the sum of two independent binomials dataIn A flexible way to import data into R. dbb The Beta-Binomial Distribution df2list Row-wise conversion of a data frame to a list dfplapply Parallelized single row processing of a data frame dframeEquiv Examines the equivalence of two dataframes or matrices dkbinom Probability functions for the sum of k independent binomials factor2character Converts all factor variables in a dataframe to character variables findDepMat Identify linearly dependent rows or columns in a matrix formatDT Converts date or datetime strings into alternate formats getExtension Filename manipulations: remove the extension or path, extract the extension or path getPath Filename manipulations: remove the extension or path, extract the extension or path grabLast Filename manipulations: remove the extension or path, extract the extension or path ifelse1 Non-vectorized version of ifelse integ Simple numerical integration routine interactionPlot Two-way Interaction Plot with Error Bar linearMap Linear mapping of a numerical vector or scalar list2df Convert a list to a data frame loadObject Loads and returns the object(s) in an ".Rdata" file more Display the contents of a file to the R terminal movAvg2 Calculate the moving average using a 2-sided window openDevice Opens a graphics device based on the filename extension p2binom Probability functions for the sum of two independent binomials padZero Pad a vector of numbers with zeros parseJob Parses a collection of elements into (almost) equal sized groups pbb The Beta-Binomial Distribution pcbinom A continuous version of the binomial cdf pkbinom Probability functions for the sum of k independent binomials plapply Simple parallelization of lapply plotFun Plot one or more functions on a single plot PowerData An example of power data pvar Prints the name and value of one or more objects qbb The Beta-Binomial Distribution rbb And numerous others (space limits reporting).« less

  17. The problem of the universal density functional and the density matrix functional theory

    SciTech Connect (OSTI)

    Bobrov, V. B. Trigger, S. A.

    2013-04-15

    The analysis in this paper shows that the Hohenberg-Kohn theorem is the constellation of two statements: (i) the mathematically rigorous Hohenberg-Kohn lemma, which demonstrates that the same ground-state density cannot correspond to two different potentials of an external field, and (ii) the hypothesis of the existence of the universal density functional. Based on the obtained explicit expression for the nonrel-ativistic particle energy in a local external field, we prove that the energy of the system of more than two non-interacting electrons cannot be a functional of the inhomogeneous density. This result is generalized to the system of interacting electrons. It means that the Hohenberg-Kohn lemma cannot provide justification of the universal density functional for fermions. At the same time, statements of the density functional theory remain valid when considering any number of noninteracting ground-state bosons due to the Bose condensation effect. In the framework of the density matrix functional theory, the hypothesis of the existence of the universal density matrix functional corresponds to the cases of noninteracting particles and to interaction in the Hartree-Fock approximation.

  18. Acidity of the amidoxime functional group in aqueous solution. A combined experimental and computational study

    SciTech Connect (OSTI)

    Mehio, Nada; Lashely, Mark A.; Nugent, Joseph W.; Tucker, Lyndsay; Correia, Bruna; Do-Thanh, Chi-Linh; Dai, Sheng; Hancock, Robert D.; Bryantsev, Vyacheslav S.

    2015-01-26

    Poly(acrylamidoxime) adsorbents are often invoked in discussions of mining uranium from seawater. It has been demonstrated repeatedly in the literature that the success of these materials is due to the amidoxime functional group. While the amidoxime-uranyl chelation mode has been established, a number of essential binding constants remain unclear. This is largely due to the wide range of conflicting pKa values that have been reported for the amidoxime functional group in the literature. To resolve this existing controversy we investigated the pKa values of the amidoxime functional group using a combination of experimental and computational methods. Experimentally, we used spectroscopic titrations to measure the pKa values of representative amidoximes, acetamidoxime and benzamidoxime. Computationally, we report on the performance of several protocols for predicting the pKa values of aqueous oxoacids. Calculations carried out at the MP2 or M06-2X levels of theory combined with solvent effects calculated using the SMD model provide the best overall performance with a mean absolute error of 0.33 pKa units and 0.35 pKa units, respectively, and a root mean square deviation of 0.46 pKa units and 0.45 pKa units, respectively. Finally, we employ our two best methods to predict the pKa values of promising, uncharacterized amidoxime ligands. Hence, our study provides a convenient means for screening suitable amidoxime monomers for future generations of poly(acrylamidoxime) adsorbents used to mine uranium from seawater.

  19. Acidity of the amidoxime functional group in aqueous solution. A combined experimental and computational study

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mehio, Nada; Lashely, Mark A.; Nugent, Joseph W.; Tucker, Lyndsay; Correia, Bruna; Do-Thanh, Chi-Linh; Dai, Sheng; Hancock, Robert D.; Bryantsev, Vyacheslav S.

    2015-01-01

    Poly(acrylamidoxime) adsorbents are often invoked in discussions of mining uranium from seawater. It has been demonstrated repeatedly in the literature that the success of these materials is due to the amidoxime functional group. While the amidoxime-uranyl chelation mode has been established, a number of essential binding constants remain unclear. This is largely due to the wide range of conflicting pKa values that have been reported for the amidoxime functional group in the literature. To resolve this existing controversy we investigated the pKa values of the amidoxime functional group using a combination of experimental and computational methods. Experimentally, we used spectroscopicmore » titrations to measure the pKa values of representative amidoximes, acetamidoxime and benzamidoxime. Computationally, we report on the performance of several protocols for predicting the pKa values of aqueous oxoacids. Calculations carried out at the MP2 or M06-2X levels of theory combined with solvent effects calculated using the SMD model provide the best overall performance with a mean absolute error of 0.33 pKa units and 0.35 pKa units, respectively, and a root mean square deviation of 0.46 pKa units and 0.45 pKa units, respectively. Finally, we employ our two best methods to predict the pKa values of promising, uncharacterized amidoxime ligands. Hence, our study provides a convenient means for screening suitable amidoxime monomers for future generations of poly(acrylamidoxime) adsorbents used to mine uranium from seawater.« less

  20. Patterned functional carbon fibers from polyethylene

    SciTech Connect (OSTI)

    Hunt, Marcus A; Saito, Tomonori; Brown, Rebecca H; Kumbhar, Amar S; Naskar, Amit K

    2012-01-01

    Patterned, continuous carbon fibers with controlled surface geometry were produced from a novel melt-processible carbon precursor. This portends the use of a unique technique to produce such technologically innovative fibers in large volume for important applications. The novelties of this technique include ease of designing and fabricating fibers with customized surface contour, the ability to manipulate filament diameter from submicron scale to a couple of orders of magnitude larger scale, and the amenable porosity gradient across the carbon wall by diffusion controlled functionalization of precursor. The geometry of fiber cross-section was tailored by using bicomponent melt-spinning with shaped dies and controlling the melt-processing of the precursor polymer. Circular, trilobal, gear-shaped hollow fibers, and solid star-shaped carbon fibers of 0.5 - 20 um diameters, either in self-assembled bundle form, or non-bonded loose filament form, were produced by carbonizing functionalized-polyethylene fibers. Prior to carbonization, melt-spun fibers were converted to a char-forming mass by optimizing the sulfonation on polyethylene macromolecules. The fibers exhibited distinctly ordered carbon morphologies at the outside skin compared to the inner surface or fiber core. Such order in carbon microstructure can be further tuned by altering processing parameters. Partially sulfonated polyethylene-derived hollow carbon fibers exhibit 2-10 fold surface area (50-500 m2/g) compared to the solid fibers (10-25 m2/g) with pore sizes closer to the inside diameter of the filaments larger than the sizes on the outer layer. These specially functionalized carbon fibers hold promise for extraordinary performance improvements when used, for example, as composite reinforcements, catalyst support media, membranes for gas separation, CO2 sorbents, and active electrodes and current collectors for energy storage applications.

  1. High Speed SPM of Functional Materials

    SciTech Connect (OSTI)

    Huey, Bryan D.

    2015-08-14

    The development and optimization of applications comprising functional materials necessitates a thorough understanding of their static and dynamic properties and performance at the nanoscale. Leveraging High Speed SPM and concepts enabled by it, efficient measurements and maps with nanoscale and nanosecond temporal resolution are uniquely feasible. This includes recent enhancements for topographic, conductivity, ferroelectric, and piezoelectric properties as originally proposed, as well as newly developed methods or improvements to AFM-based mechanical, friction, thermal, and photoconductivity measurements. The results of this work reveal fundamental mechanisms of operation, and suggest new approaches for improving the ultimate speed and/or efficiency, of data storage systems, magnetic-electric sensors, and solar cells.

  2. Accelerating functional verification of an integrated circuit

    DOE Patents [OSTI]

    Deindl, Michael; Ruedinger, Jeffrey Joseph; Zoellin, Christian G

    2015-11-05

    Illustrative embodiments include a method, system, and computer program product for accelerating functional verification in simulation testing of an integrated circuit (IC). Using a processor and a memory, a serial operation is replaced with a direct register access operation, wherein the serial operation is configured to perform bit shifting operation using a register in a simulation of the IC. The serial operation is blocked from manipulating the register in the simulation of the IC. Using the register in the simulation of the IC, the direct register access operation is performed in place of the serial operation.

  3. Accelerating functional verification of an integrated circuit

    DOE Patents [OSTI]

    Deindl, Michael; Ruedinger, Jeffrey Joseph; Zoellin, Christian G.

    2015-10-27

    Illustrative embodiments include a method, system, and computer program product for accelerating functional verification in simulation testing of an integrated circuit (IC). Using a processor and a memory, a serial operation is replaced with a direct register access operation, wherein the serial operation is configured to perform bit shifting operation using a register in a simulation of the IC. The serial operation is blocked from manipulating the register in the simulation of the IC. Using the register in the simulation of the IC, the direct register access operation is performed in place of the serial operation.

  4. Gen IV Materials Handbook Functionalities and Operation

    SciTech Connect (OSTI)

    Ren, Weiju

    2009-12-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  5. A Green's function quantum average atom model

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Starrett, Charles Edward

    2015-05-21

    A quantum average atom model is reformulated using Green's functions. This allows integrals along the real energy axis to be deformed into the complex plane. The advantage being that sharp features such as resonances and bound states are broadened by a Lorentzian with a half-width chosen for numerical convenience. An implementation of this method therefore avoids numerically challenging resonance tracking and the search for weakly bound states, without changing the physical content or results of the model. A straightforward implementation results in up to a factor of 5 speed-up relative to an optimized orbital based code.

  6. Subtask 5: Functional nanostructured transparent electrode materials |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Center for Bio-Inspired Solar Fuel Production 5: Functional nanostructured transparent electrode materials All papers by year Subtask 1 Subtask 2 Subtask 3 Subtask 4 Subtask 5 Jeon, K.-W. and Seo, D.-K. (2014) Concomitant thionation and reduction of graphene oxide through solid/gas metathetical sulfidation reactions at high temperatures, Phosphorus, Sulfur, and Silicon and the Related Elements, Published online Mar 3, 2014, , Medpelli, D., Seo, J.-M., and Seo, D.-K. (2014) Geopolymer with

  7. Functional design criteria for standard hydrogen monitoring system portable platform

    SciTech Connect (OSTI)

    Schneider, T.C.

    1997-01-17

    Functional design description for a Standard-E cabinet arrangement Standard Hydrogen Monitoring System Portable Platform.

  8. US Nuclear Regulatory Commission functional organization charts, March 15, 1993

    SciTech Connect (OSTI)

    Not Available

    1993-03-01

    Functional organization charts for the US Nuclear Regulatory Commission offices, divisions, and branches are presented.

  9. U. S. Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1989-07-01

    Functional organization charts for the US Nuclear Regulatory Commission offices, divisions and branches are presented.

  10. U. S. Nuclear Regulatory Commission functional organization charts

    SciTech Connect (OSTI)

    Not Available

    1982-02-01

    Functional organization charts for the NRC Commission Offices, Divisions, Staffs and Branches are presented.

  11. An Integrated Tool for Functional Requirements Analysis, Function Allocation and Task Analysis

    SciTech Connect (OSTI)

    Hugo, Jacques

    2015-03-02

    The software application is called “HFE-Trace”. This is an integrated method and tool for the management of Human Factors Engineering analyses and related data. Its primary purpose is to support the coherent and consistent application of the nuclear industry’s best practices for human factors engineering work. The software is a custom Microsoft® Access® application. The application is used (in conjunction with other tools such as spreadsheets, checklists and normal documents where necessary) to collect data on the design of a new nuclear power plant from subject matter experts and other sources. This information is then used to identify potential system and functional breakdowns of the intended power plant design. This information is expanded by developing extensive descriptions of all functions, as well as system performance parameters, operating limits and constraints, and operational conditions. Once these have been verified, the human factors elements are added to each function, including intended operator role, function allocation considerations, prohibited actions, primary task categories, and primary work station. In addition, the application includes a computational method to assess a number of factors such as system and process complexity, workload, environmental conditions, procedures, regulations, etc.) that may shape operator performance. This is a unique methodology based upon principles described in NUREG/CR-3331 (“A methodology for allocating nuclear power plant control functions to human or automatic control”) and it results in a semi-quantified allocation of functions to three or more levels of automation for a conceptual automation system. The aggregate of all this information is then linked to the Task Analysis section of the application where the existing information on all operator functions is transformed into task information and ultimately into design requirements for Human-System Interfaces and Control Rooms. This final step includes assessment of methods to prevent potential operator errors.

  12. An Integrated Tool for Functional Requirements Analysis, Function Allocation and Task Analysis

    Energy Science and Technology Software Center (OSTI)

    2015-03-02

    The software application is called “HFE-Trace”. This is an integrated method and tool for the management of Human Factors Engineering analyses and related data. Its primary purpose is to support the coherent and consistent application of the nuclear industry’s best practices for human factors engineering work. The software is a custom Microsoft® Access® application. The application is used (in conjunction with other tools such as spreadsheets, checklists and normal documents where necessary) to collect datamore » on the design of a new nuclear power plant from subject matter experts and other sources. This information is then used to identify potential system and functional breakdowns of the intended power plant design. This information is expanded by developing extensive descriptions of all functions, as well as system performance parameters, operating limits and constraints, and operational conditions. Once these have been verified, the human factors elements are added to each function, including intended operator role, function allocation considerations, prohibited actions, primary task categories, and primary work station. In addition, the application includes a computational method to assess a number of factors such as system and process complexity, workload, environmental conditions, procedures, regulations, etc.) that may shape operator performance. This is a unique methodology based upon principles described in NUREG/CR-3331 (“A methodology for allocating nuclear power plant control functions to human or automatic control”) and it results in a semi-quantified allocation of functions to three or more levels of automation for a conceptual automation system. The aggregate of all this information is then linked to the Task Analysis section of the application where the existing information on all operator functions is transformed into task information and ultimately into design requirements for Human-System Interfaces and Control Rooms. This final step includes assessment of methods to prevent potential operator errors.« less

  13. Joining of Tungsten Armor Using Functional Gradients

    SciTech Connect (OSTI)

    John Scott O'Dell

    2006-12-31

    The joining of low thermal expansion armor materials such as tungsten to high thermal expansion heat sink materials has been a major problem in plasma facing component (PFC) development. Conventional planar bonding techniques have been unable to withstand the high thermal induced stresses resulting from fabrication and high heat flux testing. During this investigation, innovative functional gradient joints produced using vacuum plasma spray forming techniques have been developed for joining tungsten armor to copper alloy heat sinks. A model was developed to select the optimum gradient architecture. Based on the modeling effort, a 2mm copper rich gradient was selected. Vacuum plasma pray parameters and procedures were then developed to produce the functional gradient joint. Using these techniques, dual cooling channel, medium scale mockups (32mm wide x 400mm length) were produced with vacuum plasma spray formed tungsten armor. The thickness of the tungsten armor was up to 5mm thick. No evidence of debonding at the interface between the heat sink and the vacuum plasma sprayed material was observed.

  14. Periodic subsystem density-functional theory

    SciTech Connect (OSTI)

    Genova, Alessandro; Pavanello, Michele; Ceresoli, Davide

    2014-11-07

    By partitioning the electron density into subsystem contributions, the Frozen Density Embedding (FDE) formulation of subsystem Density Functional Theory (DFT) has recently emerged as a powerful tool for reducing the computational scaling of Kohn–Sham DFT. To date, however, FDE has been employed to molecular systems only. Periodic systems, such as metals, semiconductors, and other crystalline solids have been outside the applicability of FDE, mostly because of the lack of a periodic FDE implementation. To fill this gap, in this work we aim at extending FDE to treat subsystems of molecular and periodic character. This goal is achieved by a dual approach. On one side, the development of a theoretical framework for periodic subsystem DFT. On the other, the realization of the method into a parallel computer code. We find that periodic FDE is capable of reproducing total electron densities and (to a lesser extent) also interaction energies of molecular systems weakly interacting with metallic surfaces. In the pilot calculations considered, we find that FDE fails in those cases where there is appreciable density overlap between the subsystems. Conversely, we find FDE to be in semiquantitative agreement with Kohn–Sham DFT when the inter-subsystem density overlap is low. We also conclude that to make FDE a suitable method for describing molecular adsorption at surfaces, kinetic energy density functionals that go beyond the GGA level must be employed.

  15. Surface modification of polyethylene by functionalized plasma

    SciTech Connect (OSTI)

    Yuan, S.; Marchant, R.E.

    1993-12-31

    The surface of low density polyethylene(PE) has been modified by functionalized plasma-polymerized N-vinyl-2-pyrrolidone (PPNVP) and allyl alcohol(PPAA) thin films, PPNVP and PPAA(approx. 100 nm). The surface structure and functional groups of modified surfaces were characterized by water contact angle, ATR/FTIR and ESCA techniques. Plasma polymer modified PE surfaces exhibited significant water contact angle hysteresis and a much lower value of advancing water contact angle than that of unmodified polyethylene. Reduction of PPNVP and PPAA modified surfaces by sodium borohydride coverted into hydroxyl groups. The determined concentrations of hydroxyl groups on the reduced PPNVP and PPAA modified surfaces by ESCA after gas-phase derivatization with trifluoroacetic anhydride (TFAA) were about 25% and 30% of total oxygen content, respectively. Finally, the amine containing molecules such as amine-terminated polyethylene oxide (PEO) and 3-aminopropyltriethoxysilane (APTS) were coupled to the hydroxylated surfaces. These novel modified PE surfaces are suitable for immobilization of biomolecules.

  16. Arithmetic functions in torus and tree networks

    DOE Patents [OSTI]

    Bhanot, Gyan; Blumrich, Matthias A.; Chen, Dong; Gara, Alan G.; Giampapa, Mark E.; Heidelberger, Philip; Steinmacher-Burow, Burkhard D.; Vranas, Pavlos M.

    2007-12-25

    Methods and systems for performing arithmetic functions. In accordance with a first aspect of the invention, methods and apparatus are provided, working in conjunction of software algorithms and hardware implementation of class network routing, to achieve a very significant reduction in the time required for global arithmetic operation on the torus. Therefore, it leads to greater scalability of applications running on large parallel machines. The invention involves three steps in improving the efficiency and accuracy of global operations: (1) Ensuring, when necessary, that all the nodes do the global operation on the data in the same order and so obtain a unique answer, independent of roundoff error; (2) Using the topology of the torus to minimize the number of hops and the bidirectional capabilities of the network to reduce the number of time steps in the data transfer operation to an absolute minimum; and (3) Using class function routing to reduce latency in the data transfer. With the method of this invention, every single element is injected into the network only once and it will be stored and forwarded without any further software overhead. In accordance with a second aspect of the invention, methods and systems are provided to efficiently implement global arithmetic operations on a network that supports the global combining operations. The latency of doing such global operations are greatly reduced by using these methods.

  17. Functional relationship-based alarm processing system

    DOE Patents [OSTI]

    Corsberg, D.R.

    1988-04-22

    A functional relationship-based alarm processing system and method analyzes each alarm as it is activated and determines its relative importance with other currently activated alarms and signals in accordance with the functional relationships that the newly activated alarm has with other currently activated alarms. Once the initial level of importance of the alarm has been determined, that alarm is again evaluated if another related alarm is activated or deactivated. Thus, each alarm's importance is continuously updated as the state of the process changes during a scenario. Four hierarchical relationships are defined by this alarm filtering methodology: (1) level precursor (usually occurs when there are two alarm settings on the same parameter); (2) direct precursor (based on causal factors between two alarms); (3) required action (system response or action expected within a specified time following activation of an alarm or combination of alarms and process signals); and (4) blocking condition (alarms that are normally expected and are not considered important). The alarm processing system and method is sensitive to the dynamic nature of the process being monitored and is capable of changing the relative importance of each alarm as necessary. 12 figs.

  18. Functional relationship-based alarm processing system

    DOE Patents [OSTI]

    Corsberg, Daniel R.

    1989-01-01

    A functional relationship-based alarm processing system and method analyzes each alarm as it is activated and determines its relative importance with other currently activated alarms and signals in accordance with the functional relationships that the newly activated alarm has with other currently activated alarms. Once the initial level of importance of the alarm has been determined, that alarm is again evaluated if another related alarm is activated or deactivated. Thus, each alarm's importance is continuously updated as the state of the process changes during a scenario. Four hierarchical relationships are defined by this alarm filtering methodology: (1) level precursor (usually occurs when there are two alarm settings on the same parameter); (2) direct precursor (based on causal factors between two alarms); (3) required action (system response or action expected within a specified time following activation of an alarm or combination of alarms and process signals); and (4) blocking condition (alarms that are normally expected and are not considered important). The alarm processing system and method is sensitive to the dynamic nature of the process being monitored and is capable of changing the relative importance of each alarm as necessary.

  19. Functionalized inorganic membranes for gas separation

    DOE Patents [OSTI]

    Ku, Anthony Yu-Chung; Ruud, James Anthony; Molaison, Jennifer Lynn; Schick, Louis Andrew ,; Ramaswamy, Vidya

    2008-07-08

    A porous membrane for separation of carbon dioxide from a fluid stream at a temperature higher than about 200.degree. C. with selectivity higher than Knudsen diffusion selectivity. The porous membrane comprises a porous support layer comprising alumina, silica, zirconia or stabilized zirconia; a porous separation layer comprising alumina, silica, zirconia or stabilized zirconia, and a functional layer comprising a ceramic oxide contactable with the fluid stream to preferentially transport carbon dioxide. In particular, the functional layer may be MgO, CaO, SrO, BaO, La.sub.2O.sub.3, CeO.sub.2, ATiO.sub.3, AZrO.sub.3, AAl.sub.2O.sub.4, A.sup.1FeO.sub.3, A.sup.1MnO.sub.3, A.sup.1CoO.sub.3, A.sup.1NiO.sub.3, A.sup.2HfO.sub.3, A.sup.3CeO.sub.3, Li.sub.2ZrO.sub.3, Li.sub.2SiO.sub.3, Li.sub.2TiO.sub.3 or a mixture thereof; wherein A is Mg, Ca, Sr or Ba; A.sup.1 is La, Ca, Sr or Ba; A.sup.2 is Ca, Sr or Ba; and A.sup.3 is Sr or Ba.

  20. The Gut Microbiota: Ecology and Function

    SciTech Connect (OSTI)

    Willing, B.P.; Jansson, J.K.

    2010-06-01

    The gastrointestinal (GI) tract is teeming with an extremely abundant and diverse microbial community. The members of this community have coevolved along with their hosts over millennia. Until recently, the gut ecosystem was viewed as black box with little knowledge of who or what was there or their specific functions. Over the past decade, however, this ecosystem has become one of fastest growing research areas of focus in microbial ecology and human and animal physiology. This increased interest is largely in response to studies tying microbes in the gut to important diseases afflicting modern society, including obesity, allergies, inflammatory bowel diseases, and diabetes. Although the importance of a resident community of microorganisms in health was first hypothesized by Pasteur over a century ago (Sears, 2005), the multiplicity of physiological changes induced by commensal bacteria has only recently been recognized (Hooper et al., 2001). The term 'ecological development' was recently coined to support the idea that development of the GI tract is a product of the genetics of the host and the host's interactions with resident microbes (Hooper, 2004). The search for new therapeutic targets and disease biomarkers has escalated the need to understand the identities and functions of the microorganisms inhabiting the gut. Recent studies have revealed new insights into the membership of the gut microbial community, interactions within that community, as well as mechanisms of interaction with the host. This chapter focuses on the microbial ecology of the gut, with an emphasis on information gleaned from recent molecular studies.

  1. Building a Universal Nuclear Energy Density Functional

    SciTech Connect (OSTI)

    Carlson, Joe A.; Furnstahl, Dick; Horoi, Mihai; Lust, Rusty; Nazaewicc, Witek; Ng, Esmond; Thompson, Ian; Vary, James

    2012-12-30

    During the period of Dec. 1 2006 – Jun. 30, 2012, the UNEDF collaboration carried out a comprehensive study of all nuclei, based on the most accurate knowledge of the strong nuclear interaction, the most reliable theoretical approaches, the most advanced algorithms, and extensive computational resources, with a view towards scaling to the petaflop platforms and beyond. The long-term vision initiated with UNEDF is to arrive at a comprehensive, quantitative, and unified description of nuclei and their reactions, grounded in the fundamental interactions between the constituent nucleons. We seek to replace current phenomenological models of nuclear structure and reactions with a well-founded microscopic theory that delivers maximum predictive power with well-quantified uncertainties. Specifically, the mission of this project has been three-fold:  First, to find an optimal energy density functional (EDF) using all our knowledge of the nucleonic Hamiltonian and basic nuclear properties;  Second, to apply the EDF theory and its extensions to validate the functional using all the available relevant nuclear structure and reaction data;  Third, to apply the validated theory to properties of interest that cannot be measured, in particular the properties needed for reaction theory.

  2. ALS Capabilities Reveal Multiple Functions of Ebola Virus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Capabilities Reveal Multiple Functions of Ebola Virus ALS Capabilities Reveal Multiple Functions of Ebola Virus Print Friday, 13 June 2014 10:25 A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its function. Scientists typically expect that a protein has a singular structure (with some conformational variation), and that when an experimental structure is solved, it can used to understand the known biological function(s) of the

  3. Design of the IPIRG-2 simulated seismic forcing function

    SciTech Connect (OSTI)

    Olson, R.; Scott, P.; Wilkowski, G.

    1996-02-01

    A series of pipe system experiments was conducted in IPIRG-2 that used a realistic seismic forcing function. Because the seismic forcing function was more complex than the single-frequency increasing-amplitude sinusoidal forcing function used in the IPIRG-1 pipe system experiments, considerable effort went into designing the function. This report documents the design process for the seismic forcing function used in the IPIRG-2 pipe system experiments.

  4. Progress at the interface of wave-function and density-functional theories

    SciTech Connect (OSTI)

    Gidopoulos, Nikitas I.

    2011-04-15

    The Kohn-Sham (KS) potential of density-functional theory (DFT) emerges as the minimizing effective potential in a variational scheme that does not involve fixing the unknown single-electron density. Using Rayleigh Schroedinger (RS) perturbation theory (PT), we construct ab initio approximations for the energy difference, the minimization of which determines the KS potential directly - thereby bypassing DFT's traditional algorithm to search for the density that minimizes the total energy. From second-order RS PT, we obtain variationally stable energy differences to be minimized, solving the severe problem of variational collapse of orbital-dependent exchange-correlation functionals based on second-order RS PT.

  5. Systematics of strength function sum rules

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Johnson, Calvin W.

    2015-08-28

    Sum rules provide useful insights into transition strength functions and are often expressed as expectation values of an operator. In this letter I demonstrate that non-energy-weighted transition sum rules have strong secular dependences on the energy of the initial state. Such non-trivial systematics have consequences: the simplification suggested by the generalized Brink–Axel hypothesis, for example, does not hold for most cases, though it weakly holds in at least some cases for electric dipole transitions. Furthermore, I show the systematics can be understood through spectral distribution theory, calculated via traces of operators and of products of operators. Seen through this lens,more » violation of the generalized Brink–Axel hypothesis is unsurprising: one expectssum rules to evolve with excitation energy. Moreover, to lowest order the slope of the secular evolution can be traced to a component of the Hamiltonian being positive (repulsive) or negative (attractive).« less

  6. Functional relationship-based alarm processing

    DOE Patents [OSTI]

    Corsberg, D.R.

    1987-04-13

    A functional relationship-based alarm processing system and method analyzes each alarm as it is activated and determines its relative importance with other currently activated alarms and signals in accordance with the relationships that the newly activated alarm has with other currently activated alarms. Once the initial level of importance of the alarm has been determined, that alarm is again evaluated if another related alarm is activated. Thus, each alarm's importance is continuously updated as the state of the process changes during a scenario. Four hierarchical relationships are defined by this alarm filtering methodology: (1) level precursor (usually occurs when there are two alarm settings on the same parameter); (2) direct precursor (based on causal factors between two alarms); (3) required action (system response or action expected within a specified time following activation of an alarm or combination of alarms and process signals); and (4) blocking condition (alarms that are normally expected and are not considered important). 11 figs.

  7. Function analysis for waste information systems

    SciTech Connect (OSTI)

    Sexton, J.L.; Neal, C.T.; Heath, T.C.; Starling, C.D.

    1996-04-01

    This study has a two-fold purpose. It seeks to identify the functional requirements of a waste tracking information system and to find feasible alternatives for meeting those requirements on the Oak Ridge Reservation (ORR) and the Portsmouth (PORTS) and Paducah (PGDP) facilities; identify options that offer potential cost savings to the US government and also show opportunities for improved efficiency and effectiveness in managing waste information; and, finally, to recommend a practical course of action that can be immediately initiated. In addition to identifying relevant requirements, it also identifies any existing requirements that are currently not being completely met. Another aim of this study is to carry out preliminary benchmarking by contacting representative companies about their strategic directions in waste information. The information obtained from representatives of these organizations is contained in an appendix to the document; a full benchmarking effort, however, is beyond the intended scope of this study.

  8. Gas Test Loop Functional and Technical Requirements

    SciTech Connect (OSTI)

    Glen R. Longhurst; Soli T. Khericha; James L. Jones

    2004-09-01

    This document defines the technical and functional requirements for a gas test loop (GTL) to be constructed for the purpose of providing a high intensity fast-flux irradiation environment for developers of advanced concept nuclear reactors. This capability is needed to meet fuels and materials testing requirements of the designers of Generation IV (GEN IV) reactors and other programs within the purview of the Advanced Fuel Cycle Initiative (AFCI). Space nuclear power development programs may also benefit by the services the GTL will offer. The overall GTL technical objective is to provide developers with the means for investigating and qualifying fuels and materials needed for advanced reactor concepts. The testing environment includes a fast-flux neutron spectrum of sufficient intensity to perform accelerated irradiation testing. Appropriate irradiation temperature, gaseous environment, test volume, diagnostics, and access and handling features are also needed. This document serves to identify those requirements as well as generic requirements applicable to any system of this kind.

  9. Chiral anomalies and zeta-function regularization

    SciTech Connect (OSTI)

    Reuter, M.

    1985-03-15

    The zeta-function method for regularizing determinants is used to calculate the chiral anomalies of several field-theory models. In SU(N) gauge theories without ..gamma../sub 5/ couplings, the results of perturbation theory are obtained in an unambiguous manner for the full gauge theory as well as for the corresponding external-field problem. If axial-vector couplings are present, different anomalies occur for the two cases. The result for the full gauge theory is again uniquely determined; for its nongauge analog, however, ambiguities can arise. The connection between the basic path integral and the operator used to construct the heat kernel is investigated and the significance of its Hermiticity and gauge covariance are analyzed. The implications of the Wess-Zumino conditions are considered.

  10. Visualization and functional dissection of coaxial paired SpoIIIE channels across the sporulation septum

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Shin, Jae Yen; Lopez-Garrido, Javier; Lee, Sang-Hyuk; Diaz-Celis, Cesar; Fleming, Tinya; Bustamante, Carlos; Pogliano, Kit

    2015-05-07

    SpoIIIE is a membrane-anchored DNA translocase that localizes to the septal midpoint to mediate chromosome translocation and membrane fission during Bacillus subtilis sporulation. Here we use cell-specific protein degradation and quantitative photoactivated localization microscopy in strains with a thick sporulation septum to investigate the architecture and function of the SpoIIIE DNA translocation complex in vivo. We were able to visualize SpoIIIE complexes with approximately equal numbers of molecules in the mother cell and the forespore. Cell-specific protein degradation showed that only the mother cell complex is required to translocate DNA into the forespore, whereas degradation in either cell reversesmore » membrane fission. Our data suggest that SpoIIIE assembles a coaxially paired channel for each chromosome arm comprised of one hexamer in each cell to maintain membrane fission during DNA translocation. We show that SpoIIIE can operate, in principle, as a bi-directional motor that exports DNA.« less

  11. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

    SciTech Connect (OSTI)

    Alcaraz, Jordi; Xu, Ren; Mori, Hidetoshi; Nelson, Celeste M.; Mroue, Rana; Spencer, Virginia A.; Brownfield, Doug; Radisky, Derek C.; Bustamante, Carlos; Bissell, Mina J.

    2008-10-20

    In the mammary gland, epithelial cells are embedded in a 'soft' environment and become functionally differentiated in culture when exposed to a laminin-rich extracellular matrix gel. Here, we define the processes by which mammary epithelial cells integrate biochemical and mechanical extracellular cues to maintain their differentiated phenotype. We used single cells cultured on top of gels in conditions permissive for {beta}-casein expression using atomic force microscopy to measure the elasticity of the cells and their underlying substrata. We found that maintenance of {beta}-casein expression required both laminin signalling and a 'soft' extracellular matrix, as is the case in normal tissues in vivo, and biomimetic intracellular elasticity, as is the case in primary mammary epithelial organoids. Conversely, two hallmarks of breast cancer development, stiffening of the extracellular matrix and loss of laminin signalling, led to the loss of {beta}-casein expression and non-biomimetic intracellular elasticity. Our data indicate that tissue-specific gene expression is controlled by both the tissues unique biochemical milieu and mechanical properties, processes involved in maintenance of tissue integrity and protection against tumorigenesis.

  12. 340 Facility Secondary Containment and Leak Detection Project W-302 Functional Design Criteria

    SciTech Connect (OSTI)

    Stordeur, R.T.

    1995-03-01

    This functional design criteria for the upgrade to the 340 radioactive liquid waste storage facility (Project W-302) specifically addresses the secondary containment issues at the current vault facility of the 340 Complex. This vault serves as the terminus for the Radioactive Liquid Waste System (RLWS). Project W-302 is necessary in order to bring this portion of the Complex into full regulatory compliance. The project title, ``340 Facility Secondary Containment and Leak Detection``, illustrates preliminary thoughts of taking corrective action directly upon the existing vault (such as removing the tanks, lining the vault, and replacing tanks). However, based on the conclusion of the engineering study, ``Engineering Study of the 300 Area Process Wastewater Handling System``, WHC-SD-WM-ER-277 (as well as numerous follow-up meetings with cognizant staff), this FDC prescribes a complete replacement of the current tank/vault system. This offers a greater array of tanks, and provides greater operating flexibility and ease of maintenance. This approach also minimizes disruption to RLWS services during ``tie-in``, as compared to the alternative of trying to renovate the old vault. The proposed site is within the current Complex area, and maintains the receipt of RLWS solutions through gravity flow.

  13. HANFORD SITE WELDING PROGRAM SUCCESSFULLY PROVIDING A SINGLE SITE FUNCTION FOR USE BY MULTIPLE CONTRACTORS

    SciTech Connect (OSTI)

    CANNELL GR

    2009-11-19

    The Department of Energy, Richland Operations (DOE-RL) recently restructured its Hanford work scope, awarding two new contracts over the past several months for a total of three contracts to manage the sites cleanup efforts. DOE-RL met with key contractor personnel prior to and during contract transition to ensure site welding activities had appropriate oversight and maintained code compliance. The transition also provided an opportunity to establish a single site-wide function that would provide welding and materials engineering services to the Hanford site contractors: CH2M HILL Plateau Remediation Company (CHPRC); Mission Support Alliance (MSA); Washington River Protection Solutions (WRPS); and Washington Closure Hanford (WCH). Over the years, multiple and separate welding programs (amongst the several contractors) existed at the Hanford site leading to inefficiencies resulting from duplication of administrative efforts, maintenance of welding procedures, welder performance certifications, etc. The new, single program eliminates these inefficiencies. The new program, co-managed by two of the sites' new contractors, the CHPRC ('owner' of the program and responsible for construction welding services) and the MSA (provides maintenance welding services), provides more than just the traditional construction and maintenance welding services. Also provided, are welding engineering, specialty welding development/qualification for the closure of radioactive materials containers and materials evaluation/failure analysis. The following describes the new Hanford site welding program.

  14. Implementation of the Locally Renormalized CCSD (T) Approaches for Abitrary Reference Function

    SciTech Connect (OSTI)

    Kowalski, Karol

    2005-07-01

    Several new variants of the locally-renormalized coupled-cluster (CC) approaches that account for the effect of triples (LR-CCSD(T)) have been formulated an implemented for arbitrary reference states using the TENSOR CONTRACTION ENGINE functionality, enabling an efficient parallel execution of the program. Deeply rooted in the recently derived Numerator-Denominator Connected (NDC) expansion for the ground-state energy [K. Kowalski, P. Piecuch, J. Chem. Phys. 122, 07107 (2005)], LR-CCSD(T) approximations use, in analogy to the completely-renormalized CCSD(T) (CR-CCSD(T)) approach, the three-body moments in constructing the non-iterative corrections to the energies obtained in CC calculations with singles and doubles. In contrast to the CR-CCSD(T) method, the LR-CCSD(T) approach employs local denominators which assure the additive separability of the energies in the non-interacting system limit when the localized basis set is employed in the CCSD and LR-CCSD(T) calculations. As clearly demonstrated on several challenging examples, including breaking the bonds of the F?, N?, and CN molecules, the LR-CCSD(T) approaches are capable of providing a highly accurate description of the entire potential energy surface (PES) while maintaining the characteristic N? scaling of the ubiquitous CCSD(T) approach. Moreover, as illustrated numerically for the ozone molecule, the LR-CCSD(T) approaches yield highly competitive values for a number of equilibrium properties including bond lengths, angles and harmonic frequencies.

  15. Functional Stability Of A Mixed Microbial Consortia Producing PHA From Waste Carbon Sources

    SciTech Connect (OSTI)

    David N. Thompson; Erik R. Coats; William A. Smith; Frank J. Loge; Michael P. Wolcott

    2006-04-01

    Polyhydroxyalkanoates (PHAs), naturally-occurring biological polyesters that are microbially synthesized from a myriad of carbon sources, can be utilized as biodegradable substitutes for petroleum-derived thermoplastics. However, current PHA commercialization schemes are limited by high feedstock costs, the requirement for aseptic reactors, and high separation and purification costs. Bacteria indigenous to municipal waste streams can accumulate large quantities of PHA under environmentally controlled conditions; hence, a potentially more environmentally-effective method of production would utilize these consortia to produce PHAs from inexpensive waste carbon sources. In this study, PHA production was accomplished in sequencing batch bioreactors utilizing mixed microbial consortia from municipal activated sludge as inoculum, in cultures grown on real wastewaters. PHA production averaged 85%, 53%, and 10% of the cell dry weight from methanol-enriched pulp-and-paper mill foul condensate, fermented municipal primary solids, and biodiesel wastewater, respectively. The PHA-producing microbial consortia were examined to explore the microbial community changes that occurred during reactor operations, employing denaturing gradient gel electrophoresis (DGGE) of 16S-rDNA from PCR-amplified DNA extracts. Distinctly different communities were observed both between and within wastewaters following enrichment. More importantly, stable functions were maintained despite the differing and contrasting microbial populations.

  16. Full-wave Simulations of ICRF Heating in Toroidal Plasma with Non-Maxwellian Distribution Functions in the FLR Limit

    SciTech Connect (OSTI)

    E.J. Valeo, C.K. Phillips, H. Okuda, J.C. Wright, P.T. Bonoli, L.A. Berry, and the RF SciDAC Team

    2007-07-18

    At the power levels required for signicant heating and current drive in magnetically-con ned toroidal plasma, modi cation of the particle distribution function from a Maxwellian shape is likely [T.H. Stix, Nucl. Fusion, 15:737 1975], with consequent changes in wave propagation and in the location and amount of absorption. In order to study these e ects computationally, the nite-Larmor-radius, full-wave, hot-plasma toroidal simulation code, TORIC [M. Brambilla. Plasma Phys. Controlled Fusion, 41:1, 1999], has been extended to allow the prescription of arbitrary velocity distributions of the form (?||, ??, ?, ?). For H minority heating of a D-H plasma with anisotropic Maxwellian H distributions, the fractional H absorption varies signi cantly with changes in parallel temperature but is essentially independent of perpendicular temperature.

  17. Structure of a Specialized Acyl Carrier Protein Essential for Lipid A Biosynthesis with Very Long-chain Fatty Acids in Open and Closed Conformations

    SciTech Connect (OSTI)

    Ramelot, Theresa A.; Rossi, Paolo M.; Forouhar, Farhad; Lee, Hsiau-Wei; Yang, Yunhuang; Ni, Shuisong; Unser, Sarah; Lew, Scott; Seetharaman, Jayaraman; Xiao, Rong; Acton, Thomas; Everett, John K.; Prestegard, James H.; Hunt, John F.; Montelione, Gaetano; Kennedy, Michael A.

    2012-09-18

    The solution nuclear magnetic resonance (NMR) structures and backbone (15)N dynamics of the specialized acyl carrier protein (ACP), RpAcpXL, from Rhodopseudomonas palustris, in both the apo form and holo form modified by covalent attachment of 4'-phosphopantetheine at S37, are virtually identical, monomeric, and correspond to the closed conformation. The structures have an extra ?-helix compared to the archetypical ACP from Escherichia coli, which has four helices, resulting in a larger opening to the hydrophobic cavity. Chemical shift differences between apo- and holo-RpAcpXL indicated some differences in the hinge region between ?2 and ?3 and in the hydrophobic cavity environment, but corresponding changes in nuclear Overhauser effect cross-peak patterns were not detected. In contrast to the NMR structures, apo-RpAcpXL was observed in an open conformation in crystals that diffracted to 2.0 resolution, which resulted from movement of ?3. On the basis of the crystal structure, the predicted biological assembly is a homodimer. Although the possible biological significance of dimerization is unknown, there is potential that the resulting large shared hydrophobic cavity could accommodate the very long-chain fatty acid (28-30 carbons) that this specialized ACP is known to synthesize and transfer to lipid A. These structures are the first representatives of the AcpXL family and the first to indicate that dimerization may be important for the function of these specialized ACPs.

  18. HAM-5 functions as a MAP kinase scaffold during cell fusion in Neurospora crassa

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Jonkers, Wilfried; Leeder, Abigail C.; Ansong, Charles; Wang, Yuexi; Yang, Feng; Starr, Trevor L.; Camp, II, David G.; Smith, Richard D.; Glass, N. Louise; Heitman, Joseph

    2014-11-20

    Cell fusion in genetically identical Neurospora crassa germlings and in hyphae is a highly regulated process involving the activation of a conserved MAP kinase cascade that includes NRC1, MEK2 and MAK2. During chemotrophic growth in germlings, the MAP kinase cascade members localize to conidial anastomosis tube (CAT) tips every 4 minutes, perfectly out of phase with another protein that is recruited to the tip: SOFT, a protein of unknown biochemical function. How this oscillation process is initiated, maintained and what proteins regulate the MAP kinase cascade is currently unclear. A global phosphoproteomics approach using an allele of mak-2 (mak-2Q100G) thatmore » can be specifically inhibited by the ATP analog 1NM-PP1 was utilized to identify MAK2 kinase targets in germlings that were potentially involved in this process. One such putative target was HAM5, a protein of unknown biochemical function. Previously, Δham-5 mutants were shown to be deficient for hyphal fusion. Here we show that HAM5-GFP co-localized with NRC1, MEK2 and MAK2 and oscillated with identical dynamics from the cytoplasm to CAT tips during chemotropic interactions. In the Δmak-2 strain, HAM5-GFP localized to punctate complexes that did not oscillate, but still localized to the germling tip, suggesting that MAK2 activity influences HAM5 function/localization. However, MAK2-GFP showed only cytoplasmic and nuclear localization in a Δham-5 strain and did not localize to puncta, as observed in wild type germlings. Via co-immunoprecipitation experiments, HAM5 was shown to physically interact with MAK2, MEK2 and NRC1, suggesting that it functions as a scaffold/transport hub for the MAP kinase cascade members during oscillation and chemotropic interactions during both germling and hyphal fusion in N. crassa. The identification of HAM5 as a scaffold-like protein will help to link the activation of MAK2 to upstream factors and other proteins involved in this intriguing process of fungal communication.« less

  19. Complementary influence functions for predicting subsidence caused by mining

    SciTech Connect (OSTI)

    Sutherland, H.J.; Munson, D.E.

    1982-01-01

    Surface subsidence caused by underground mining is described through complementary influence functions. The complementary functions developed here differ from the simple functions previously used in that the surface displacement is the result of the combined contributions of the mined and unmined zones. This eliminates computational difficulties experienced with the simple functions in determining the deflections above the rib side and in the eventual application of influence functions to complex room-and-pillar configurations. Although the analysis framework presented is intended for predicting subsidence over complex mine configurations, use of the complementary functions is illustrated adequately by application to a longwall panel of the Old Ben No. 24 coal mine.

  20. Two Studies Reveal Details of Lithium-Battery Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Two Studies Reveal Details of Lithium-Battery Function Two Studies Reveal Details of Lithium-Battery Function Print Wednesday, 27 February 2013 00:00 Our way of life is deeply ...

  1. Tank waste remediation system functions and requirements document

    SciTech Connect (OSTI)

    Carpenter, K.E

    1996-10-03

    This is the Tank Waste Remediation System (TWRS) Functions and Requirements Document derived from the TWRS Technical Baseline. The document consists of several text sections that provide the purpose, scope, background information, and an explanation of how this document assists the application of Systems Engineering to the TWRS. The primary functions identified in the TWRS Functions and Requirements Document are identified in Figure 4.1 (Section 4.0) Currently, this document is part of the overall effort to develop the TWRS Functional Requirements Baseline, and contains the functions and requirements needed to properly define the top three TWRS function levels. TWRS Technical Baseline information (RDD-100 database) included in the appendices of the attached document contain the TWRS functions, requirements, and architecture necessary to define the TWRS Functional Requirements Baseline. Document organization and user directions are provided in the introductory text. This document will continue to be modified during the TWRS life-cycle.

  2. When Function Follows Form: Plastic Solar Cells | ANSER Center |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Argonne-Northwestern National Laboratory When Function Follows Form: Plastic Solar Cells Home > Research > ANSER Research Highlights > When Function Follows Form: Plastic Solar Cells

  3. Green Functions for the Radial Electric Component of the Monopole...

    Office of Scientific and Technical Information (OSTI)

    Green Functions for the Radial Electric Component of the Monopole Wake Field in a Round Resistive Chamber Citation Details In-Document Search Title: Green Functions for the Radial...

  4. On strongly GA-convex functions and stochastic processes

    SciTech Connect (OSTI)

    Bekar, Nurgl Okur; Akdemir, Hande Gnay; ??can, ?mdat

    2014-08-20

    In this study, we introduce strongly GA-convex functions and stochastic processes. We provide related well-known Kuhn type results and Hermite-Hadamard type inequality for strongly GA-convex functions and stochastic processes.

  5. ALS Capabilities Reveal Multiple Functions of Ebola Virus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Functions of Ebola Virus Print Friday, 13 June 2014 10:25 A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its function....

  6. Functional relationship-based alarm processing

    DOE Patents [OSTI]

    Corsberg, Daniel R.

    1988-01-01

    A functional relationship-based alarm processing system and method analyzes each alarm as it is activated and determines its relative importance with other currently activated alarms and signals in accordance with the relationships that the newly activated alarm has with other currently activated alarms. Once the initial level of importance of the alarm has been determined, that alarm is again evaluated if another related alarm is activated. Thus, each alarm's importance is continuously oupdated as the state of the process changes during a scenario. Four hierarchical relationships are defined by this alarm filtering methodology: (1) level precursor (usually occurs when there are two alarm settings on the same parameter); (2) direct precursor (based on caussal factors between two alarms); (3) required action (system response or action) expected within a specified time following activation of an alarm or combination of alarms and process signals); and (4) blocking condition (alarms that are normally expected and are not considered important). The alarm processing system and method is sensitive to the dynamic nature of the process being monitored and is capable of changing the relative importance of each alarm as necessary.

  7. Orbital-optimized density cumulant functional theory

    SciTech Connect (OSTI)

    Sokolov, Alexander Yu. Schaefer, Henry F.

    2013-11-28

    In density cumulant functional theory (DCFT) the electronic energy is evaluated from the one-particle density matrix and two-particle density cumulant, circumventing the computation of the wavefunction. To achieve this, the one-particle density matrix is decomposed exactly into the mean-field (idempotent) and correlation components. While the latter can be entirely derived from the density cumulant, the former must be obtained by choosing a specific set of orbitals. In the original DCFT formulation [W. Kutzelnigg, J. Chem. Phys. 125, 171101 (2006)] the orbitals were determined by diagonalizing the effective Fock operator, which introduces partial orbital relaxation. Here we present a new orbital-optimized formulation of DCFT where the energy is variationally minimized with respect to orbital rotations. This introduces important energy contributions and significantly improves the description of the dynamic correlation. In addition, it greatly simplifies the computation of analytic gradients, for which expressions are also presented. We offer a perturbative analysis of the new orbital stationarity conditions and benchmark their performance for a variety of chemical systems.

  8. Controlling formation fines at their sources to maintain well productivity

    SciTech Connect (OSTI)

    Nguyen, P.D.; Weaver, J.D.; Rickman, R.D.; Dusterhoft, R.G.; Parker, M.A.

    2007-05-15

    Migration of formation fines has been shown to cause production decline in many wells. Despite the availability of new downhole tools for use in well stimulation and completion, the ability to sustain desired production levels is often plagued with fines migration problems. The solution to this problem is appropriate treatment to mitigate fines migration at its source. This paper describes the use of an ultra-thin tackifying agent (UTTA) for stabilizing fines in high-rate producing or injection wells. This UTTA is applied as part of an initial prepad in fracturing or gravel-packing operations, as a remedial treatment, or as a post-treatment following acid fracturing or matrix acidizing treatments. The primary purpose of UTTA application is to immobilize formation fines so that they will not detach, migrate with flowing fluids, plug the pore channels, and reduce the flow path permeability. Results of laboratory testing indicate that the UTTA system is applicable to most types of formation fines, including coals, sandstones, and carbonates. Once injected into the formation matrix or proppant pack, the UTTA forms a thin film on formation surfaces, encapsulating the fines. Capillary action helps pull the tackifier into the contact points, fixing the particulate in place without plugging the pore throat. The UTTA does not require a shut-in time after its application. The thin film tackifier does not harden, but remains flexible, enhancing the ability of a formation to withstand stress cycling and allowing the formation to handle high shear stress during high flow rates.

  9. Installing and Maintaining a Home Solar Electric System | Department...

    Energy Savers [EERE]

    ... (W) or kilowatts (kW). If possible, have the bids specify the system capacity in "AC Watts" (alternating current) under ... Also request an estimate of the amount of energy that the ...

  10. Installing and Maintaining a Home Solar Electric System | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    a Home Solar Electric System When choosing a contractor, ask about their work record, experience, and licenses, and get more than one bid for the installation of your PV...

  11. Doing it right the first time: Maintaining densitometer calibration

    SciTech Connect (OSTI)

    Burgwardt, L.C.

    1995-09-01

    A densitometer is a key tool for controlling the exposure and development process during radiographic film-based nondestructive testing (NDT) procedures. Yet it may be one of the most overlooked sources of problems affecting the quality of radiographic tests. Radiography labs that provide NDT pay a great deal of attention to their radiation sources, processing procedures, and skilled readings of sample defects in final images. Whether the exposure is created by light or a radiographic source, all photographic processes produce an image on film which consists of a range of densities. Reading the densities of a radiograph detects cracks or subtle fractures to determine if a flaw exists in an aircraft structure, a pipe weld, or any other hidden surface. The visibility of the defect is dependent upon proper exposure and processing of the film. A densitometer helps control those variables. And good densitometer habits, including regular calibration and testing of the densitometer, are an investment in good results.

  12. System for Automatically Maintaining Pressure in a Commercial Truck Tire

    Broader source: Energy.gov [DOE]

    2012 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  13. 10 CFR 1008, Records Maintained On Individuals (Privacy Act)...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    FIA-13-0077 - In the Matter of John F. Garrity FIA-13-0014 - In the Matter of Aaron Silberstein Executive Order 13148-Greening the Government Through Leadership in...

  14. 1 ISO 14001 requires that operational control be maintained...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    bins with improved collection bins to include color coding for recycling categories and trash receptacles. Improve Life Cycle Management of Electronics 12. Complete phase I...

  15. Guide to Operating and Maintaining EnergySmart Schools

    SciTech Connect (OSTI)

    2009-06-01

    This guide is a primary resource for developing and implementing a district- or school- wide operations and maintenance (O&M) program that focuses on energy efficiency.

  16. Installing and Maintaining a Small Wind Electric System | Department of

    Office of Environmental Management (EM)

    Inspection/Sampling Schedule Inspection/Sampling Schedule Site Inspection and Water Sampling Schedules Note: The following schedules are subject to change without prior notice and will be updated periodically. Site Name Inspection Date Sampling Week Ambrosia Lake, NM, Disposal Site August 22, 2016 December 3, 2015 Bluewater, NM, Disposal Site August 22, 2016 December 2, 2015 May 9, 2016 BONUS, PR, Decommissioned Reactor Site FY 2017 No annual inspections N/A Burrell, PA, Disposal Site October

  17. Installing and Maintaining a Small Wind Electric System | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Deciding whether to connect the system to the electric grid or not. Installation and Maintenance The manufacturer of your wind system, or the dealer where you bought it, should be...

  18. Establishing & Maintaining a Strategic Partnership with the Chief...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    that integrates aspects of operations-use this knowledge to position your project Speaking the Language of Finance * Engineers & CFOs use the same words to mean different ...

  19. Creating and maintaining a gas cap in tar sands formations

    DOE Patents [OSTI]

    Vinegar, Harold J. (Bellaire, TX); Karanikas, John Michael (Houston, TX); Dinkoruk, Deniz Sumnu (Houston, TX); Wellington, Scott Lee (Bellaire, TX)

    2010-03-16

    Methods for treating a tar sands formation are disclosed herein. Methods for treating a tar sands formation may include providing heat to at least part of a hydrocarbon layer in the formation from one or more heaters located in the formation. Pressure may be allowed to increase in an upper portion of the formation to provide a gas cap in the upper portion. At least some hydrocarbons are produced from a lower portion of the formation.

  20. Installing and Maintaining a Small Wind Electric System | Department...

    Broader source: Energy.gov (indexed) [DOE]

    ... However, you should contact your utility before connecting to its distribution lines to address any power quality and safety concerns. Your utility can provide you with a list of ...

  1. System for maintaining materials at freezer temperatures for shipping

    DOE Patents [OSTI]

    Schabron, John F.; Sorini-Wong, Susan S.

    2007-08-28

    At least one embodiment of the inventive technology relates to a frozen environmental sample temperature control system that comprises a frozen formulation having water in an amount from substantially 87% to 78% by weight of the formulation, and salt in an amount from substantially 13% to 22% by weight of the formulation, the system further including at least one container containing the frozen formulation; and a cooler having insulating material disposed between an outer wall and an inner surface that defines an inner chamber into which the at least one container and the at least one frozen environmental sample may be placed for storage and/or transport. Various embodiments may incorporate specific types of insulating material and/or adaptations to an inner surface of the cooler to enhance the insulation effected thereby.

  2. Guide to Operating and Maintaining EnergySmart Schools

    Broader source: Energy.gov (indexed) [DOE]

    a district- or school-wide operations and maintenance (O&M) program that focuses on energy efficiency. The EnergySmart Schools Solutions companion CD contains additional sup-...

  3. Tuesday Webcast for Industry: Establishing and Maintaining a...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Some of the "tools" such as off balance sheet fnancing have been greatly constrained by regulation and general aversion in the wake of the WorldCom and Enron scandals that made use ...

  4. 10 CFR 1008, Records Maintained On Individuals (Privacy Act)...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    FIA-13-0014 - In the Matter of Aaron Silberstein FIA-13-0077 - In the Matter of John F. Garrity EO 13148: Greening the Government Through Leadership in Environmental Management ...

  5. Operating and Maintaining Your Heat Pump | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    heat pump performance unless your system uses a high-efficiency, variable-speed fan motor. ... Lubricate motors, and inspect belts for tightness and wear Verify correct electric control...

  6. Y-12 Construction maintains 'superb' safety performance | Y-12...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    B&W Y-12 vice president of projects, presents Construction's safety awards to Monica Lewis, Y-12 craft safety lead representative, and Kevin Adkisson, Knoxville Building and...

  7. EnergySmart Schools Tips: Retrofitting, Operating, and Maintaining...

    Broader source: Energy.gov (indexed) [DOE]

    EnergySmart Schools fact sheet that discusses quick wins and long-term facility management strategies that pay for themselves and result in energy savings. essquick-winsfs.pdf...

  8. Pore Surface Engineering with Controlled Loadings of Functional...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pore Surface Engineering with Controlled Loadings of Functional Groups via Click Chemistry in Highly Stable Metal-Organic Frameworks...

  9. Internal compiler error for function pointer with identically named

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    arguments Internal compiler error for function pointer with identically named arguments Internal compiler error for function pointer with identically named arguments June 9, 2015 by Scott French, NERSC USG Status: Bug 21435 reported to PGI For pgcc versions after 12.x (up through 12.9 is fine, but 13.x and 14.x are not), you may observe an internal compiler error associated with function pointer prototypes when named arguments are used. Specifically, if a function pointer type is defined

  10. Methods for integrating a functional component into a microfluidic device

    DOE Patents [OSTI]

    Simmons, Blake; Domeier, Linda; Woo, Noble; Shepodd, Timothy; Renzi, Ronald F.

    2014-08-19

    Injection molding is used to form microfluidic devices with integrated functional components. One or more functional components are placed in a mold cavity, which is then closed. Molten thermoplastic resin is injected into the mold and then cooled, thereby forming a solid substrate including the functional component(s). The solid substrate including the functional component(s) is then bonded to a second substrate, which may include microchannels or other features.

  11. Silver nanoparticles with tunable work functions (Journal Article) |

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Silver nanoparticles with tunable work functions Citation Details In-Document Search Title: Silver nanoparticles with tunable work functions To improve the efficiencies of electronic devices, materials with variable work functions are required to decrease the energy level differences at the interfaces between working layers. Here, we report a method to obtain silver nanoparticles with tunable work functions, which have the same silver core of 5 nm in diameter and are capped

  12. Virtual photon fragmentation functions (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Virtual photon fragmentation functions Citation Details In-Document Search Title: Virtual photon fragmentation functions We introduce operator definitions for virtual photon fragmentation functions, which are needed for reliable calculations of Drell-Yan transverse momentum (Q{sub T}) distributions when Q{sub T} is much larger than the invariant mass Q. We derive the evolution equations for these fragmentation functions. We calculate the leading order evolution kernels for partons to fragment

  13. POLICY GUIDANCE MEMORANDUM #25 Functional Accountability | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy 5 Functional Accountability POLICY GUIDANCE MEMORANDUM #25 Functional Accountability Policy Statement reiterating that the Human Resources Directors (HRDs) are accountable to the Chief Human Capital Officer (CHCO) on matters pertaining to Functional Accountability. PDF icon Guidance Memorandum #25 Functional Accountability Responsible Contacts George Waldmann SUPERVISORY HUMAN RESOURCES SPECIALIST E-mail george.waldmann@hq.doe.gov Phone 202-586-9904 More Documents & Publications

  14. Directed Organization of Functional Materials at Inorganic-Macromolecular

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Interfaces Alex Noy is the Principal Investigator for Directed Organization of Functional Materials at Inorganic-Macromolecular Interfaces. Directed Organization of Functional Materials at Inorganic-Macromolecular Interfaces Research The purpose of this project is to develop a quantitative physical picture of macromolecular organization and its relationship to function, and to use macromolecular organization to derive new functionality. The project has several major subtasks in addition to

  15. ALS Capabilities Reveal Multiple Functions of Ebola Virus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Capabilities Reveal Multiple Functions of Ebola Virus Print A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its function. Scientists typically expect that a protein has a singular structure (with some conformational variation), and that when an experimental structure is solved, it can used to understand the known biological function(s) of the protein. Recently, researchers used beamline capabilities at the ALS to demonstrate that a

  16. Quark-gluon correlation functions relevant to single transverse spin

    Office of Scientific and Technical Information (OSTI)

    asymmetries (Journal Article) | SciTech Connect Quark-gluon correlation functions relevant to single transverse spin asymmetries Citation Details In-Document Search Title: Quark-gluon correlation functions relevant to single transverse spin asymmetries We investigate the relative size of various twist-3 quark-gluon correlation functions relevant to single transverse spin asymmetries (SSAs) in a quark-diquark model of the nucleon. We calculate the quark-gluon correlation function T{sub

  17. Functional Ecological Gene Networks to Reveal the Changes Among...

    Office of Scientific and Technical Information (OSTI)

    indicating the potential importance of network interactions in ecosystem functioning. ... aremore fundamentally important for research in microbial ecology, systems ...

  18. ALS Capabilities Reveal Multiple Functions of Ebola Virus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Capabilities Reveal Multiple Functions of Ebola Virus Print A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its function. Scientists typically expect that a protein has a singular structure (with some conformational variation), and that when an experimental structure is solved, it can used to understand the known biological function(s) of the protein. Recently, researchers used beamline capabilities at the ALS to demonstrate that a

  19. ALS Capabilities Reveal Multiple Functions of Ebola Virus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Capabilities Reveal Multiple Functions of Ebola Virus Print A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its function. Scientists typically expect that a protein has a singular structure (with some conformational variation), and that when an experimental structure is solved, it can used to understand the known biological function(s) of the protein. Recently, researchers used beamline capabilities at the ALS to demonstrate that a

  20. ALS Capabilities Reveal Multiple Functions of Ebola Virus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Capabilities Reveal Multiple Functions of Ebola Virus Print A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its function. Scientists typically expect that a protein has a singular structure (with some conformational variation), and that when an experimental structure is solved, it can used to understand the known biological function(s) of the protein. Recently, researchers used beamline capabilities at the ALS to demonstrate that a

  1. Functional Mock-up Unit Export of EnergyPlus

    Energy Science and Technology Software Center (OSTI)

    2012-08-01

    The Functional Mock-up Unit Export of EnergyPlus is a software package that allows EnergyPlus to be exported as a Functional Mock-up Unit. This allows other software tools to run EnergyPlus as part of a larger simulation. To do so, the outside software needs to implement the Functional Mock-up interface standard (http://www.modelisar.com/), and be able to import Functional Mock-up Units for co-simulation.

  2. Biosensors Based on Functionalized Carbon Nanotubes, Nanoparticles, and Nanowires

    SciTech Connect (OSTI)

    Wang, Jun; Liu, Guodong; Wu, Hong; Lin, Yuehe

    2009-01-01

    In this book chapter, we will review recent progress in functionalization of nanotubes, nanoparticles, and nanowires for sensing applications.

  3. US Nuclear Regulatory Commission functional organization charts. Revision 6

    SciTech Connect (OSTI)

    Not Available

    1984-01-01

    The report consists entirely of organizational charts of the US NRC, with functional notes for each office. (GHT)

  4. US Nuclear Regulatory Commission functional organization charts, January 31, 1992

    SciTech Connect (OSTI)

    Not Available

    1992-02-01

    Functional organization charts for the US Nuclear Regulatory Commission offices, divisions, and branches are presented in this document.

  5. GeoChips for Analysis of Microbial Functional Communities (Book...

    Office of Scientific and Technical Information (OSTI)

    Methods covered include preparation of DNA (whole community genome amplification and ... Subject: 59; AMPLIFICATION; BUFFERS; COMMUNITIES; DNA; ENZYMES; FUNCTIONALS; GENES; ...

  6. A nanobody directed to a functional epitope on VEGF, as a novel strategy for cancer treatment

    SciTech Connect (OSTI)

    Farajpour, Zahra; Rahbarizadeh, Fatemeh; Kazemi, Bahram; Ahmadvand, Davoud

    2014-03-28

    Highlights: A novel nanobody directed to antigenic regions on VEGF was identified. Our nanobody was successfully purified. Our nanobody significantly inhibited VEGF-induced proliferation of HUVECs in a dose dependent manner. - Abstract: Compelling evidence suggests that vascular endothelial growth factor (VEGF), due to its essential role in angiogenesis, is a critical target for cancer treatment. Neutralizing monoclonal antibodies against VEGF are important class of drugs used in cancer therapy. However, the cost of production, large size, and immunogenicity are main drawbacks of conventional monoclonal therapy. Nanobodies are the smallest antigen-binding antibody fragments, which occur naturally in camelidae. Because of their remarkable features, we decided to use an immune library of nanobody to direct phage display to recognition of novel functional epitopes on VEGF. Four rounds of selection were performed and six phage-displayed nanobodies were obtained from an immune phage library. The most reactive clone in whole-cell ELISA experiments, was purified and assessed in proliferation inhibition assay. Purified ZFR-5 not only blocked interaction of VEGF with its receptor in cell ELISA experiments, but also was able to significantly inhibit proliferation response of human umbilical vein endothelial cells to VEGF in a dose-dependent manner. Taken together, our study demonstrates that by using whole-cell ELISA experiments, nanobodies against antigenic regions included in interaction of VEGF with its receptors can be directed. Because of unique and intrinsic properties of a nanobody and the ability of selected nanobody for blocking the epitope that is important for biological function of VEGF, it represents novel potential drug candidate.

  7. Modeling mixtures of thyroid gland function disruptors in a vertebrate alternative model, the zebrafish eleutheroembryo

    SciTech Connect (OSTI)

    Thienpont, Benedicte; Barata, Carlos; Ralda, Demetrio

    2013-06-01

    Maternal thyroxine (T4) plays an essential role in fetal brain development, and even mild and transitory deficits in free-T4 in pregnant women can produce irreversible neurological effects in their offspring. Women of childbearing age are daily exposed to mixtures of chemicals disrupting the thyroid gland function (TGFDs) through the diet, drinking water, air and pharmaceuticals, which has raised the highest concern for the potential additive or synergic effects on the development of mild hypothyroxinemia during early pregnancy. Recently we demonstrated that zebrafish eleutheroembryos provide a suitable alternative model for screening chemicals impairing the thyroid hormone synthesis. The present study used the intrafollicular T4-content (IT4C) of zebrafish eleutheroembryos as integrative endpoint for testing the hypotheses that the effect of mixtures of TGFDs with a similar mode of action [inhibition of thyroid peroxidase (TPO)] was well predicted by a concentration addition concept (CA) model, whereas the response addition concept (RA) model predicted better the effect of dissimilarly acting binary mixtures of TGFDs [TPO-inhibitors and sodium-iodide symporter (NIS)-inhibitors]. However, CA model provided better prediction of joint effects than RA in five out of the six tested mixtures. The exception being the mixture MMI (TPO-inhibitor)-KClO{sub 4} (NIS-inhibitor) dosed at a fixed ratio of EC{sub 10} that provided similar CA and RA predictions and hence it was difficult to get any conclusive result. There results support the phenomenological similarity criterion stating that the concept of concentration addition could be extended to mixture constituents having common apical endpoints or common adverse outcomes. - Highlights: Potential synergic or additive effect of mixtures of chemicals on thyroid function. Zebrafish as alternative model for testing the effect of mixtures of goitrogens. Concentration addition seems to predict better the effect of mixtures of goitrogens.

  8. Magnetic spectroscopy and microscopy of functional materials

    SciTech Connect (OSTI)

    Jenkins, C.A.

    2011-01-28

    Heusler intermetallics Mn{sub 2}Y Ga and X{sub 2}MnGa (X; Y =Fe, Co, Ni) undergo tetragonal magnetostructural transitions that can result in half metallicity, magnetic shape memory, or the magnetocaloric effect. Understanding the magnetism and magnetic behavior in functional materials is often the most direct route to being able to optimize current materials for todays applications and to design novel ones for tomorrow. Synchrotron soft x-ray magnetic spectromicroscopy techniques are well suited to explore the the competing effects from the magnetization and the lattice parameters in these materials as they provide detailed element-, valence-, and site-specifc information on the coupling of crystallographic ordering and electronic structure as well as external parameters like temperature and pressure on the bonding and exchange. Fundamental work preparing the model systems of spintronic, multiferroic, and energy-related compositions is presented for context. The methodology of synchrotron spectroscopy is presented and applied to not only magnetic characterization but also of developing a systematic screening method for future examples of materials exhibiting any of the above effects. The chapter progression is as follows: an introduction to the concepts and materials under consideration (Chapter 1); an overview of sample preparation techniques and results, and the kinds of characterization methods employed (Chapter 2); spectro- and microscopic explorations of X{sub 2}MnGa/Ge (Chapter 3); spectroscopic investigations of the composition series Mn{sub 2}Y Ga to the logical Mn{sub 3}Ga endpoint (Chapter 4); and a summary and overview of upcoming work (Chapter 5). Appendices include the results of a Think Tank for the Graduate School of Excellence MAINZ (Appendix A) and details of an imaging project now in progress on magnetic reversal and domain wall observation in the classical Heusler material Co{sub 2}FeSi (Appendix B).

  9. Observation concerning the process dependence of the Sivers functions

    Office of Scientific and Technical Information (OSTI)

    (Journal Article) | SciTech Connect Observation concerning the process dependence of the Sivers functions Citation Details In-Document Search Title: Observation concerning the process dependence of the Sivers functions The k{sub perpendicular} moment of a quark's Sivers function is known to be related to the corresponding twist-three quark-gluon correlation function T{sub q,F}(x,x). The two functions have been extracted from data for single-spin asymmetries in semi-inclusive deep-inelastic

  10. Surface functionalized mesoporous material and method of making same

    DOE Patents [OSTI]

    Feng, Xiangdong [West Richland, WA; Liu, Jun [West Richland, WA; Fryxell, Glen E. [Kennewick, WA

    2001-12-04

    According to the present invention, an organized assembly of functional molecules with specific interfacial functionality (functional group(s)) is attached to available surfaces including within mesopores of a mesoporous material. The method of the present invention avoids the standard base soak that would digest the walls between the mesopores by boiling the mesoporous material in water for surface preparation then removing all but one or two layers of water molecules on the internal surface of a pore. Suitable functional molecule precursor is then applied to permeate the hydrated pores and the precursor then undergoes condensation to form the functional molecules on the interior surface(s) of the pore(s).

  11. GeoChip-based analysis of functional microbial communities in a bioreduced uranium-contaminated aquifer during reoxidation by oxygen

    SciTech Connect (OSTI)

    Van Nostrand, J.D.; Wu, W.-M.; Wu, L.; Deng, Y.; Carley, J.; Carroll, S.; He, Z.; Gu, B.; Luo, J.; Criddle, C. S.; Watson, D. B.; Jardine, P. M.; Tiedje, J. M.; Hazen, T. C.; Zhou, J.

    2009-07-15

    A pilot-scale system was established for in situ biostimulation of U(VI) reduction by ethanol addition at the US Department of Energy's (DOE's) Field Research Center (Oak Ridge, TN). After achieving U(VI) reduction, stability of the bioreduced U(IV) was evaluated under conditions of (i) resting (no ethanol injection), (ii) reoxidation by introducing dissolved oxygen (DO), and (iii) reinjection of ethanol. GeoChip, a functional gene array with probes for N, S and C cycling, metal resistance and contaminant degradation genes, was used for monitoring groundwater microbial communities. High diversity of all major functional groups was observed during all experimental phases. The microbial community was extremely responsive to ethanol, showing a substantial change in community structure with increased gene number and diversity after ethanol injections resumed. While gene numbers showed considerable variations, the relative abundance (i.e. percentage of each gene category) of most gene groups changed little. During the reoxidation period, U(VI) increased, suggesting reoxidation of reduced U(IV). However, when introduction of DO was stopped, U(VI) reduction resumed and returned to pre-reoxidation levels. These findings suggest that the community in this system can be stimulated and that the ability to reduce U(VI) can be maintained by the addition of electron donors. This biostimulation approach may potentially offer an effective means for the bioremediation of U(VI)-contaminated sites.

  12. GeoChip-based analysis of functional microbial communities during the reoxidation of a bioreduced uranium-contaminated aquifer

    SciTech Connect (OSTI)

    Van Nostrand, Joy; Wu, Weimin; Wu, Liyou; Deng, Ye; Carley, Jack M; Carroll, Sue L; He, Zhili; Gu, Baohua; Luo, Jian; Criddle, Craig; Watson, David B; Jardine, Philip M; Marsh, Terence; Tiedje, James; Hazen, T. C.; Zhou, Jizhong

    2009-01-01

    A pilot-scale system was established for in situ biostimulation of U(VI) reduction by ethanol addition at the US Department of Energy's (DOE's) Field Research Center (Oak Ridge, TN). After achieving U(VI) reduction, stability of the bioreduced U(IV) was evaluated under conditions of (i) resting (no ethanol injection), (ii) reoxidation by introducing dissolved oxygen (DO), and (iii) reinjection of ethanol. GeoChip, a functional gene array with probes for N, S and C cycling, metal resistance and contaminant degradation genes, was used for monitoring groundwater microbial communities. High diversity of all major functional groups was observed during all experimental phases. The microbial community was extremely responsive to ethanol, showing a substantial change in community structure with increased gene number and diversity after ethanol injections resumed. While gene numbers showed considerable variations, the relative abundance (i.e. percentage of each gene category) of most gene groups changed little. During the reoxidation period, U(VI) increased, suggesting reoxidation of reduced U(IV). However, when introduction of DO was stopped, U(VI) reduction resumed and returned to pre-reoxidation levels. These findings suggest that the community in this system can be stimulated and that the ability to reduce U(VI) can be maintained by the addition of electron donors. This biostimulation approach may potentially offer an effective means for the bioremediation of U(VI)-contaminated sites.

  13. Functional One-Dimensional Lipid Bilayers on Carbon Nanotube Templates

    SciTech Connect (OSTI)

    Artyukhin, A; Shestakov, A; Harper, J; Bakajin, O; Stroeve, P; Noy, A

    2004-07-23

    We present one-dimensional (1-D) lipid bilayer structures that integrate carbon nanotubes with a key biological environment-phospholipid membrane. Our structures consist of lipid bilayers wrapped around carbon nanotubes modified with a hydrophilic polymer cushion layer. Despite high bilayer curvature, the lipid membrane maintains its fluidity and can sustain repeated damage-recovery cycles. We also present the first evidence of spontaneous insertion of pore-forming proteins into 1-D lipid bilayers. These structures could lead to the development of new classes of biosensors and bioelectronic devices.

  14. Continuity Program | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Continuity Program NNSA develops and implements the policy of the United States to maintain a comprehensive and effective continuity capability composed of an integrated, overlapping national continuity concept in order to ensure the preservation of the U.S. government and the continuing performance of federal agencies' essential functions. All federal agencies, regardless of location, would have in place a viable continuity program capability to ensure continued performance of essential

  15. Continuity of Operations (COOP) Implementation Plan | U.S. DOE Office of

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Continuity Program NNSA develops and implements the policy of the United States to maintain a comprehensive and effective continuity capability composed of an integrated, overlapping national continuity concept in order to ensure the preservation of the U.S. government and the continuing performance of federal agencies' essential functions. All federal agencies, regardless of location, would have in place a viable continuity program capability to ensure continued performance of essential

  16. Covalently functionalized carbon nanostructures and methods for their separation

    DOE Patents [OSTI]

    Wang, YuHuang; Brozena, Alexandra H; Deng, Shunliu; Zhang, Yin

    2015-03-17

    The present invention is directed to carbon nanostructures, e.g., carbon nanotubes, methods of covalently functionalizing carbon nanostructures, and methods of separating and isolating covalently functionalized carbon. In some embodiments, carbon nanotubes are reacted with alkylating agents to provide water soluble covalently functionalized carbon nanotubes. In other embodiments, carbon nanotubes are reacted with a thermally-responsive agent and exposed to light in order to separate carbon nanotubes of a specific chirality from a mixture of carbon nanotubes.

  17. Poly(ethyleneoxide) functionalization through alkylation (Patent) | SciTech

    Office of Scientific and Technical Information (OSTI)

    Connect Poly(ethyleneoxide) functionalization through alkylation Citation Details In-Document Search Title: Poly(ethyleneoxide) functionalization through alkylation A new and efficient method of functionalizing high molecular weight polymers through alkylation using a metal amide base is described. This novel procedure can also be used to synthesize polymer-based macro-initiators containing radical initiating groups at the chain-ends for synthesis of block copolymers. Authors: Sivanandan,

  18. Functions | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Functions Information Technology and Services (ITS) ITS Home About Functions Contact Information Information Technology and Services U.S. Department of Energy SC-45/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-0192 F: (301) 903-2481 Functions Print Text Size: A A A FeedbackShare Page Table of Contents: Office of Director for Information Technology and Services Program Management Office (PMO) IT Financials Asset Management Records Management Communications and

  19. Evolution of twist-3 multiparton correlation functions relevant to single

    Office of Scientific and Technical Information (OSTI)

    transverse-spin asymmetry (Journal Article) | SciTech Connect Evolution of twist-3 multiparton correlation functions relevant to single transverse-spin asymmetry Citation Details In-Document Search Title: Evolution of twist-3 multiparton correlation functions relevant to single transverse-spin asymmetry We construct two sets of twist-3 correlation functions that are responsible for generating the novel single transverse-spin asymmetry in the QCD collinear factorization approach. We derive

  20. SECURITY CORE FUNCTION AND DEFINITION REPORT | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    SECURITY CORE FUNCTION AND DEFINITION REPORT SECURITY CORE FUNCTION AND DEFINITION REPORT The first phase of the Lemnos Interoperable Security Program shall lay the foundation for future work by providing a guiding example of the vocabulary, metrics, interoperability requirements and interoperability assurance methodologies used to create interoperable network security products. From a requirements definition perspective, this translates to: PDF icon SECURITY CORE FUNCTION AND DEFINITION REPORT