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Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Trust Anchor  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Trust Anchors in Software * Advanced from State Machines -> Turing Machines * C++, Java, OCaml - Test, Validate, and Improve Trust Anchors * Show Any Algorithm Can be Secured...

2

Trust Anchor  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Adrian R Chavez Adrian R Chavez Sandia National Laboratories Protecting PCS against Lifecycle Attacks Using Trust Anchors Summary Slide: Trust Anchors / Code Seal  Outcomes: Trust Anchor technology enables new security strategies addressing lifecycle attacks for which there are currently no relevant defenses  Roadmap Challenge: Develop and Integrate Protective Measures  Major Successes: Implemented and improved performance of trust anchor algorithms and implementation  Schedule: Implement Trust Anchors 3/10; Performance Testing/Prototype 8/10; Scenario Development 1/11; Vulnerability Assessment 3/11  Level of Effort: $400K  Funds Remaining: $257K  Performers: SNL  Partners: Exploring industry opportunities to commercialize technology CodeSeal CodeSeal

3

Trust in health infomediaries  

Science Conference Proceedings (OSTI)

Health infomediaries play an increasingly critical role in providing support for people's health and wellness decisions. Effectiveness of health infomediaries depends on people's trust in them. In this paper, we conceptualize a comprehensive synthesis ... Keywords: Health infomediary, Information quality, Risk belief, System quality, Trust, Trust beliefs, Trust signs

Jaeki Song; Fatemeh "Mariam" Zahedi

2007-03-01T23:59:59.000Z

4

Propagation of trust and distrust  

Science Conference Proceedings (OSTI)

A (directed) network of people connected by ratings or trust scores, and a model for propagating those trust scores, is a fundamental building block in many of today's most successful e-commerce and recommendation systems. We develop a framework of trust ... Keywords: distrust, trust propagation, web of trust

R. Guha; Ravi Kumar; Prabhakar Raghavan; Andrew Tomkins

2004-05-01T23:59:59.000Z

5

B-Trust: bayesian trust framework for pervasive computing  

Science Conference Proceedings (OSTI)

Without trust, pervasive devices cannot collaborate effectively, and without collaboration, the pervasive computing vision cannot be made a reality. Distributed trust frameworks may support trust and thus foster collaboration in an hostile pervasive ...

Daniele Quercia; Stephen Hailes; Licia Capra

2006-05-01T23:59:59.000Z

6

MSTC - Microsystems Science, Technology, and Components - Trusted  

NLE Websites -- All DOE Office Websites (Extended Search)

Trusted Microsystems Trusted Microsystems Microsystems Home Custom Microsystems Solutions Microsystems R&D Services Capabilities and Technologies Facilities Trusted Microsystems General Info About Us Awards Contacts Doing Business with Us Fact Sheets MESA News Trusted Microsystems for National Security Customers Trusted R&D Trusted Design Trusted Fabrication Trusted BEOL Trusted Custom Electronic Components Trusted Microsystems "Trusted Microsystems" encompasses the entire product development cycle. Sandia's Microsystems Center affords access to trusted people and facilities for research and development, design, layout, fabrication, characterization, packaging, and test. Trusted Design Secure design facility with disciplined and trusted design flow and methodologies Trusted Structured ASIC

7

Trust management survey  

Science Conference Proceedings (OSTI)

Trust is an important tool in human life, as it enables people to cope with the uncertainty caused by the free will of others. Uncertainty and uncontrollability are also issues in computer-assisted collaboration and electronic commerce in particular. ...

Sini Ruohomaa; Lea Kutvonen

2005-05-01T23:59:59.000Z

8

Trusted Computing Technologies, Intel Trusted Execution Technology.  

Science Conference Proceedings (OSTI)

We describe the current state-of-the-art in Trusted Computing Technologies - focusing mainly on Intel's Trusted Execution Technology (TXT). This document is based on existing documentation and tests of two existing TXT-based systems: Intel's Trusted Boot and Invisible Things Lab's Qubes OS. We describe what features are lacking in current implementations, describe what a mature system could provide, and present a list of developments to watch. Critical systems perform operation-critical computations on high importance data. In such systems, the inputs, computation steps, and outputs may be highly sensitive. Sensitive components must be protected from both unauthorized release, and unauthorized alteration: Unauthorized users should not access the sensitive input and sensitive output data, nor be able to alter them; the computation contains intermediate data with the same requirements, and executes algorithms that the unauthorized should not be able to know or alter. Due to various system requirements, such critical systems are frequently built from commercial hardware, employ commercial software, and require network access. These hardware, software, and network system components increase the risk that sensitive input data, computation, and output data may be compromised.

Guise, Max Joseph; Wendt, Jeremy Daniel

2011-01-01T23:59:59.000Z

9

Propagating and aggregating trust with uncertainty measure  

Science Conference Proceedings (OSTI)

Trust networks have been recognized as a valuable component of many modern systems, such as e-commerce or recommender systems, as they provide a way of quality assessment. In addition to adequate modeling of trust in such network, two fundamental issues ... Keywords: IFS, global trust, intuitionistic fuzzy sets, local trust, relative scalar cardinality of IFS, trust aggregation, trust propagation

Anna Stachowiak

2011-09-01T23:59:59.000Z

10

Trust: A Collision of Paradigms  

E-Print Network (OSTI)

In this work we survey the findings in social psychology and philosophy with respect to trust. We introduce three

Camp, L. Jean

2002-07-22T23:59:59.000Z

11

Propagation of Trust and Distrust  

E-Print Network (OSTI)

A network of people connected by directed ratings or trust scores, and a model for propagating those trust scores, is a fundamental building block in many of today's most successful e-commerce and recommendation systems. In eBay, such a model of trust has significant influence on the price an item may command. In Epinions (epinions.com), conclusions drawn from the web of trust are linked to many behaviors of the system, including decisions on items to which each user is exposed. We develop a framework of trust propagation schemes, each of which may be appropriate in certain circumstances, and evaluate the schemes on a large trust network consisting of 800K trust scores expressed among 130K people. We show that a small number of expressed trusts/distrust per individual allows us to predict reliably trust between any two people in the system with high accuracy: a quadratic increase in actionable information. Our work appears to be the first to incorporate distrust in a computational trust propagation setting.

R. Guha; Ravi Kumar; Prabhakar Raghavan; Andrew Tomkins

2004-01-01T23:59:59.000Z

12

Advanced Credentialing for Trusted Networks  

back to their trust network profiles; and (4) an Internet accessible application that links member profiles to mobile applications. Advantages Hardware agnostic

13

Barrier Slicing for Remote Software Trusting  

Science Conference Proceedings (OSTI)

Remote trusting aims at verifying the "healthy" execution of a program running on an untrusted client that communicates with a trusted server via network connection. After giving a formal definition of the remote trusting problem and a test to determine ...

Mariano Ceccato; Mila Dalla Preda; Jasvir Nagra; Christian Collberg; Paolo Tonella

2007-09-01T23:59:59.000Z

14

Trusted virtual containers on demand  

Science Conference Proceedings (OSTI)

TPM-based trusted computing aspires to use hardware and cryptography to provide a remote relying party with assurances about the trustworthiness of a computing environment. However, standard approaches to trusted computing are hampered in the areas of ... Keywords: containers, dtrace, power, zones

Katelin A. Bailey; Sean W. Smith

2010-10-01T23:59:59.000Z

15

Personalised and dynamic trust in social networks  

Science Conference Proceedings (OSTI)

We propose a novel trust metric for social networks which is suitable for application to recommender systems. It is personalised and dynamic, and allows to compute the indirect trust between two agents which are not neighbours based on the direct trust ... Keywords: information overload, personalisation, recommender systems, social networks, trust

Frank E. Walter; Stefano Battiston; Frank Schweitzer

2009-10-01T23:59:59.000Z

16

An interoperable context sensitive model of trust  

Science Conference Proceedings (OSTI)

Although the notion of trust is widely used in secure information systems, very few works attempt to formally define it or reason about it. Moreover, in most works, trust is defined as a binary concept--either an entity is completely trusted or not at ... Keywords: Reputation, Trust

Indrakshi Ray; Indrajit Ray; Sudip Chakraborty

2009-02-01T23:59:59.000Z

17

Trust in the Home Network  

E-Print Network (OSTI)

Introduction: insight and awareness trust aspects Basics: Privacy and Security Trust, the Value Chain and its implications The Road ahead Introduction Heighthen awareness of, and increase insight into: TRUST the VA.U. CHAIl Roles and Responsibilities of Vendors and Service Providers legal setting (national vs international; contract law, intellectual property, copyright & patents, redress Trust in the Home Network Value Chain TNO-II-L Twente, 2? lebruary 2001 ho? to provide, on a platter: to-do list tips and pointers for hacker-free environment list of applications to use, and which not to use The BASICS Kinds of information delivered to the Home .nvironment Multimedia entertainment services Alarm monitoring and domoticslhome management control Financial transactions Medical transactions Contractual transactions In other words, ALL information needs some kind of security measure Basic terminology (1) ? Availability timely, reliable access to da

Peter Hupkens; Principal Consultant; Introduction Insight

2001-01-01T23:59:59.000Z

18

A Metric for Trusted Systems  

Science Conference Proceedings (OSTI)

... bB p BA p dBd A p = dB p BA p uBd A p ... People may nd the opinion model unfamiliar, and di erent individuals may produce con ... 5 Modelling Trust ...

1998-10-28T23:59:59.000Z

19

GENERAL SOCIAL TRUST AND POLITICAL TRUST WITHIN SOCIAL AND POLITICAL GROUPS: A CASE STUDY.  

E-Print Network (OSTI)

??People in society with high levels of generalized social trust and political trust are more likely to engage in civic activism and participation. Therefore, people (more)

Craig, Weylan

2006-01-01T23:59:59.000Z

20

Workshop on Improving Trust in the Online Marketplace ...  

Science Conference Proceedings (OSTI)

... Andrews, Rick - CAs Alone Do Not Provide Trust. Bender, Jens; Schnherr, Kerstin - Enhancing Trust by Enhancing the Audit Process. ...

2013-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Climate Trust | Open Energy Information  

Open Energy Info (EERE)

Name Climate Trust Name Climate Trust Place Portland, Oregon Zip OR 97204 Product The Climate Trust is a non-profit organization providing solutions to reduce GHG emissions Coordinates 45.511795°, -122.675629° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":45.511795,"lon":-122.675629,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

22

Trust negotiation: authorization for virtual organizations  

Science Conference Proceedings (OSTI)

Trust negotiation is an authorization approach for open distributed systems, such as dynamic coalitions and other types of virtual organizations. Under the trust negotiation approach to authorization, every resource that might be shared within the coalition ...

M. Winslett; Adam J. Lee; Kenneth J. Perano

2009-04-01T23:59:59.000Z

23

Building Trust & Confidence in Voting Systems  

Science Conference Proceedings (OSTI)

Building Trust & Confidence in Voting Systems, Dec 10-11, 2003. Dec 10, 2003. ... Openness & Security David Dill Stanford University. ...

2012-11-07T23:59:59.000Z

24

Trusting to learn: trust and privacy issues in serious games  

Science Conference Proceedings (OSTI)

Organizations are increasingly investing in technology-enhanced learning systems to improve their employees' skills. Serious games are one example; the competitive and fun nature of games is supposed to motivate employee participation. But any system ... Keywords: privacy, serious games, technology-enhanced learning, trust

Miguel Malheiros; Charlene Jennett; Will Seager; M. Angela Sasse

2011-06-01T23:59:59.000Z

25

A survey of trust in social networks  

Science Conference Proceedings (OSTI)

Web-based social networks have become popular as a medium for disseminating information and connecting like-minded people. The public accessibility of such networks with the ability to share opinions, thoughts, information, and experience offers great ... Keywords: Trust management, social networks, social trust, trust models

Wanita Sherchan, Surya Nepal, Cecile Paris

2013-08-01T23:59:59.000Z

26

Content-triggered trust negotiation  

Science Conference Proceedings (OSTI)

The focus of access control in client/server environments is on protecting sensitive server resources by determining whether or not a client is authorized to access those resources. The set of resources is usually static, and an access control policy ... Keywords: Trust negotiation, access control, authentication, credentials

Adam Hess; Jason Holt; Jared Jacobson; Kent E. Seamons

2004-08-01T23:59:59.000Z

27

PARS II Configuration Update - Trusted Publisher  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Configuration Update - Trusted Publisher Configuration Update - Trusted Publisher As of July 15, 2013, all reports within SSS Reports will require a new Trusted Publisher to be accepted in order for reports to present correctly and as intended. The new Trusted Publisher certificate has been issued to the US Department of Energy by Entrust Code Signing Certification Authority - L1D and is valid until 4/22/2016. Depending upon the security settings within your domain for your workstation, administrative rights may be required to accept the new Trusted Publisher. If required, please contact your local IT Helpdesk for assistance. The original Trusted Publisher certificate, Dekker Ltd., may remain within your configuration settings. Acceptance of the new Trusted Publisher in no way affects any current reporting requirements.

28

Ubiquitous Trust: Evolving Trust into Ubiquitous Computing Environments  

E-Print Network (OSTI)

Ubiquitous computing environments are the culmination of the advances from both mobile computing the ability to move computing services with us and pervasive computing the ability to obtain information from the environment and dynamically configure services such that any computing device, while moving with us, can build incrementally dynamic models of its various environments and configure its services accordingly (Lyytinen & Yoo, 2002). As with many past technologies, a number of technical and behavioral factors will interplay to influence the success of any design or deployment. Once such factor, trust, has become an increasingly important topic in the computing disciplines. Researchers are studying trust in a variety of technology-based contexts such as e-business (Coutu, 1998; Friedman, Kahn & Howe,

Joseph S. Valacich

2003-01-01T23:59:59.000Z

29

Water law - Public Trust Doctrine  

SciTech Connect

In a case involving California's Mono Lake, the State Supreme Court held that infringement of the values protected by the Public Trust Doctrine is a separate ground for challenging water appropriations, and that the continuing nature of the state's duty as trustee prevents the acquisition of a vested right to appropriations that injure navigation, commerce, and fisheries. The author summarizes the history and the competing claims of the Doctrine and the California Appropriative Water Rights System. The National Audubon suit now makes it possible for any member of the public to challenge any surface water diversion as injurious to the public trust, but it also offers the California courts an opportunity to redirect the state's water policies. 130 references.

Casey, E.S.

1984-07-01T23:59:59.000Z

30

A situation-aware computational trust model for selecting partners  

Science Conference Proceedings (OSTI)

Trust estimation is a fundamental process in several multiagent systems domains, from social networks to electronic business scenarios. However, the majority of current computational trust systems is still too simplistic and is not situation-aware, jeopardizing ... Keywords: computational trust systems, dynamics of trust, multi-agent systems, situationaware trust

Joana Urbano; Ana Paula Rocha; Eugnio Oliveira

2011-01-01T23:59:59.000Z

31

Carbon Trust Enterprises Limited | Open Energy Information  

Open Energy Info (EERE)

Enterprises Limited Enterprises Limited Jump to: navigation, search Name Carbon Trust Enterprises Limited Place London, United Kingdom Zip WC2A 2AZ Sector Carbon Product Carbon Trust Enterprises creates and invests in new, high growth, carbon reducing businesses. Typically the company focuses on use of mature technologies rather than on technology innovations. References Carbon Trust Enterprises Limited[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Carbon Trust Enterprises Limited is a company located in London, United Kingdom . References ↑ "Carbon Trust Enterprises Limited" Retrieved from "http://en.openei.org/w/index.php?title=Carbon_Trust_Enterprises_Limited&oldid=343250"

32

Trust and multi-agent systems: applying the "diffuse, default model" of trust to experiments involving artificial agents  

Science Conference Proceedings (OSTI)

We argue that the notion of trust, as it figures in an ethical context, can be illuminated by examining research in artificial intelligence on multi-agent systems in which commitment and trust are modeled. We begin with an analysis of a philosophical ... Keywords: Artificial agents, Default trust, Diffuse trust, Multi-agent systems, Trust

Jeff Buechner; Herman T. Tavani

2011-03-01T23:59:59.000Z

33

Energy Trust of Oregon | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Trust of Oregon Trust of Oregon Energy Trust of Oregon < Back Eligibility Agricultural Commercial Industrial Institutional Local Government Multi-Family Residential Nonprofit Residential Schools State Government Utility Savings Category Heating & Cooling Commercial Heating & Cooling Heating Home Weatherization Construction Commercial Weatherization Design & Remodeling Heat Pumps Appliances & Electronics Commercial Lighting Lighting Manufacturing Water Heating Windows, Doors, & Skylights Bioenergy Buying & Making Electricity Alternative Fuel Vehicles Hydrogen & Fuel Cells Water Solar Wind Program Info State Oregon Program Type Public Benefits Fund Provider The Energy Trust of Oregon Oregon's 1999 electric-utility restructuring legislation (SB 1149) required Pacific Power and Portland General Electric (PGE) to collect a 3%

34

Trusted Geolocation in the Cloud Technical Demonstration  

Science Conference Proceedings (OSTI)

... is sponsored by the NIST National Cybersecurity Center of Excellence (NCCoE) titled "Trusted Geolocation in the Cloud Technical Demonstration". ...

2013-01-04T23:59:59.000Z

35

GRR/Section 3-OR-b - Easements on Trust and Non-Trust Land | Open Energy  

Open Energy Info (EERE)

GRR/Section 3-OR-b - Easements on Trust and Non-Trust Land GRR/Section 3-OR-b - Easements on Trust and Non-Trust Land < GRR Jump to: navigation, search GRR-logo.png GEOTHERMAL REGULATORY ROADMAP Roadmap Home Roadmap Help List of Sections Section 3-OR-b - Easements on Trust and Non-Trust Land 03ORBEasementsOnTrustAndNonTrustLand (2).pdf Click to View Fullscreen Contact Agencies Oregon Department of State Lands Regulations & Policies OAR 141-122-0010 Rules for Granting Easements on Trust and Non-Trust Land Triggers None specified Click "Edit With Form" above to add content 03ORBEasementsOnTrustAndNonTrustLand (2).pdf Error creating thumbnail: Page number not in range. Error creating thumbnail: Page number not in range. Error creating thumbnail: Page number not in range. Flowchart Narrative An easement of this kind may be used for fiber optic cables, encroachments,

36

Trust: Economic Notions and its role in Money and Banking.  

E-Print Network (OSTI)

??This thesis has two aims; to explore the economic notions of trust to develop a coherent understanding of trust within economics and to apply this (more)

Hughes, Peter T.

2010-01-01T23:59:59.000Z

37

Cyberspace Policy Review: Assuring a Trusted and Resilient Information...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Policy Review: Assuring a Trusted and Resilient Information and Communications Infrastructure Cyberspace Policy Review: Assuring a Trusted and Resilient Information and...

38

DualTrust: A Distributed Trust Model for Swarm-Based Autonomic Computing Systems  

SciTech Connect

For autonomic computing systems that utilize mobile agents and ant colony algorithms for their sensor layer, trust management is important for the acceptance of the mobile agent sensors and to protect the system from malicious behavior by insiders and entities that have penetrated network defenses. This paper examines the trust relationships, evidence, and decisions in a representative system and finds that by monitoring the trustworthiness of the autonomic managers rather than the swarming sensors, the trust management problem becomes much more scalable and still serves to protect the swarm. We then propose the DualTrust conceptual trust model. By addressing the autonomic managers bi-directional primary relationships in the ACS architecture, DualTrust is able to monitor the trustworthiness of the autonomic managers, protect the sensor swarm in a scalable manner, and provide global trust awareness for the orchestrating autonomic manager.

Maiden, Wendy M.; Dionysiou, Ioanna; Frincke, Deborah A.; Fink, Glenn A.; Bakken, David E.

2011-02-01T23:59:59.000Z

39

UMLtrust: towards developing trust-aware software  

Science Conference Proceedings (OSTI)

As users in software systems depend on each other for achieving goals, performing tasks, and utilizing resources, the trust relationships in the systems need to be considered to identify the opportunities and vulnerabilities these relationships bring. ... Keywords: software development life cycle (SDLC), trust scenario, unified modeling language (UML)

Mohammad Gias Uddin; Mohammad Zulkernine

2008-03-01T23:59:59.000Z

40

Managing trust in distributed agent systems  

Science Conference Proceedings (OSTI)

Software agent technology has attracted much attention for developing various distributed systems, composed of autonomous agents interacting with one another using particular mechanisms and protocols. Such systems provide high-level reconfigurability, ... Keywords: distributed agent systems, security, situation-awareness, trust, trust management

Stephen S. Yau

2006-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Hybrid Trust Model for Internet Routing  

E-Print Network (OSTI)

The current Internet is based on a fundamental assumption of reliability and good intent among actors in the network. Unfortunately, unreliable and malicious behaviour is becoming a major obstacle for Internet communication. In order to improve the trustworthiness and reliability of the network infrastructure, we propose a novel trust model to be incorporated into BGP routing. In our approach, trust model is defined by combining voting and recommendation to direct trust estimation for neighbour routers located in different autonomous systems. We illustrate the impact of our approach with cases that demonstrate the indication of distrusted paths beyond the nearest neighbours and the detection of a distrusted neighbour advertising a trusted path. We simulated the impact of weighting voted and direct trust in a rectangular grid of 15*15 nodes (autonomous systems) with a randomly connected topology.

Rantala, Pekka; Isoaho, Jouni

2011-01-01T23:59:59.000Z

42

Abstract - Enhancing Trust by Enhancing the Audit Process  

Science Conference Proceedings (OSTI)

... including network security requirements Topic: Enhancing Trust by Enhancing the Audit Process Authors: Kerstin Schnherr ...

2013-03-12T23:59:59.000Z

43

Declaration Of Trust | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Declaration Of Trust Declaration Of Trust Declaration Of Trust Our Bank Deposit Financial Assistance Program was developed for the purpose of strengthening and expanding the Nation's minority and women-owned small business enterprises. In order to classify as "minority" the institution's majority ownership must include African Americans, Hispanic Americans, Asian Americans, American Indians, Eskimos, Aleuts, and women. The minority institution must certify minority ownership with the Department of the Treasury and appear on Treasury's Roster of Financial Institutions Participating in the Federal Government's Minority Bank Deposit Program. In keeping with the intent of the Program, we purchase certificates of deposit from those minority financial institutions which desire to

44

Efficiency Maine Trust | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Efficiency Maine Trust Efficiency Maine Trust Efficiency Maine Trust < Back Eligibility Agricultural Commercial Industrial Institutional Local Government Nonprofit Residential Schools State Government Savings Category Wind Buying & Making Electricity Program Info State Maine Program Type Public Benefits Fund Maine's public benefits fund for energy efficiency was authorized originally in 1997 by the state's electric-industry restructuring legislation. Under the initial arrangement, the administration of certain efficiency programs was divided among the State Planning Office (SPO), the state's electric utilities and the Maine Public Utilities Commission (PUC). However, general dissatisfaction by the Maine Legislature (and many other stakeholders) with the administration of the fund prompted revisions in

45

Trust Anchor Fact Sheet.cdr  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Trust Anchor Lifecycle Attack Protection Trust Anchor Lifecycle Attack Protection Trust Anchor Lifecycle Attack Protection Cryptographically secure software providing independent testing, monitoring, and control of energy control system component operation Cryptographically secure software providing independent testing, monitoring, and control of energy control system component operation Cyber Security for Energy Delivery Systems Electricity Delivery & Energy Reliability Project Lead: Sandia National Laboratories The Concept The Approach Commercial-off-the-shelf energy control systems and components are primarily designed, produced, and maintained by foreign companies. With control of commercial hardware and software supply chains and routine access through configuration and updates, foreign developers have an unprecedented

46

DualTrust: A Trust Management Model for Swarm-Based Autonomic Computing Systems  

Science Conference Proceedings (OSTI)

Trust management techniques must be adapted to the unique needs of the application architectures and problem domains to which they are applied. For autonomic computing systems that utilize mobile agents and ant colony algorithms for their sensor layer, certain characteristics of the mobile agent ant swarm -- their lightweight, ephemeral nature and indirect communication -- make this adaptation especially challenging. This thesis looks at the trust issues and opportunities in swarm-based autonomic computing systems and finds that by monitoring the trustworthiness of the autonomic managers rather than the swarming sensors, the trust management problem becomes much more scalable and still serves to protect the swarm. After analyzing the applicability of trust management research as it has been applied to architectures with similar characteristics, this thesis specifies the required characteristics for trust management mechanisms used to monitor the trustworthiness of entities in a swarm-based autonomic computing system and describes a trust model that meets these requirements.

Maiden, Wendy M.

2010-05-01T23:59:59.000Z

47

Supply chain trust diagnosis (SCTD) using inductive case-based reasoning ensemble (ICBRE): The case of general competence trust diagnosis  

Science Conference Proceedings (OSTI)

General competence trust among supply chain partners, referring to the trust that a partner holds the general ability of fulfilling contracts, is a critical factor to ensure effective cooperation in a supply chain, especially in the current financial ... Keywords: General competence trust, Inductive case-based reasoning ensemble (ICBRE), Supply chain trust diagnosis (SCTD) service

Hui Li; Jie Sun; Jian Wu; Xian-Jun Wu

2012-08-01T23:59:59.000Z

48

Standard Steam Trust LLC | Open Energy Information  

Open Energy Info (EERE)

Steam Trust LLC Steam Trust LLC (Redirected from Standard Steam Trust) Jump to: navigation, search Name Standard Steam Trust LLC Place Denver, Colorado Sector Geothermal energy Product Subsidiary of Denver-based geothermal project developer, Terra Caliente. Coordinates 39.74001°, -104.992259° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":39.74001,"lon":-104.992259,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

49

Westwind Trust Wind Farm | Open Energy Information  

Open Energy Info (EERE)

Westwind Trust Wind Farm Westwind Trust Wind Farm Jump to: navigation, search Name Westwind Trust Wind Farm Facility Westwind Trust Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Energy Purchaser Southern California Edison Co Location San Gorgonio CA Coordinates 33.9095°, -116.734° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.9095,"lon":-116.734,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

50

Sustainable Energy Trust Fund | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Sustainable Energy Trust Fund Sustainable Energy Trust Fund Sustainable Energy Trust Fund < Back Eligibility Commercial General Public/Consumer Industrial Institutional Residential Utility Savings Category Bioenergy Buying & Making Electricity Solar Heating & Cooling Commercial Heating & Cooling Heating Water Heating Wind Program Info State District of Columbia Program Type Public Benefits Fund Provider Energy Division The District of Columbia's Retail Electric Competition and Consumer Protection Act of 1999 required the DC Public Service Commission (PSC) to establish a public benefits fund to provide energy assistance to low-income residents, and to support energy-efficiency programs and renewable-energy programs. This fund, known as the Reliable Energy Trust Fund (RETF), took effect in 2001. In October 2008, the District of Columbia enacted the Clean

51

Massachusetts Technology Collaborative - Renewable Energy Trust | Open  

Open Energy Info (EERE)

Technology Collaborative - Renewable Energy Trust Technology Collaborative - Renewable Energy Trust Jump to: navigation, search Logo: Massachusetts Technology Collaborative - Renewable Energy Trust Name Massachusetts Technology Collaborative - Renewable Energy Trust Address 75 North Drive Place Westborough, Massachusetts Zip 01581 Region Greater Boston Area Coordinates 42.2882622°, -71.630121° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":42.2882622,"lon":-71.630121,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

52

Renewable Energy Trust Fund | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Renewable Energy Trust Fund Renewable Energy Trust Fund Renewable Energy Trust Fund < Back Eligibility Agricultural Commercial Industrial Institutional Nonprofit Residential Schools Utility Savings Category Bioenergy Commercial Heating & Cooling Manufacturing Buying & Making Electricity Alternative Fuel Vehicles Hydrogen & Fuel Cells Water Solar Home Weatherization Wind Program Info State Massachusetts Program Type Public Benefits Fund Provider Massachusetts Clean Energy Center The renewable energy fund, known as the Massachusetts Renewable Energy Trust Fund, is supported by a non-bypassable surcharge of $0.0005 per kilowatt-hour (0.5 mill/kWh), imposed on customers of all investor-owned electric utilities and competitive municipal utilities in Massachusetts. (Non-competitive municipal utilities generally may opt into the Fund by

53

Tropical Forest Trust | Open Energy Information  

Open Energy Info (EERE)

Tropical Forest Trust Tropical Forest Trust Name Tropical Forest Trust Address The Forest Trust 721 NW Ninth Avenue, Suite 195 Place Portland, Oregon Zip 97209 Region Pacific Northwest Area Year founded 1999 Website http://www.tft-forests.org/ Coordinates 45.5284073°, -122.6803494° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":45.5284073,"lon":-122.6803494,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

54

Regional Revolving Loan Trust Fund (New York)  

Energy.gov (U.S. Department of Energy (DOE))

The Regional Revolving Loan Trust Fund Program, coordinated by the Empire State Development program, is operated in six regions by nonprofit organizations and provides working capital loans (up to ...

55

Trusted lifelon nancial partners TIAA-CREF's Financial Consultants build trusted lifelong  

E-Print Network (OSTI)

Trusted lifelon nancial partners TIAA-CREF's Financial Consultants build trusted lifelong - ized is eligible to participate in an employer- sponsored retirement plan through TIAA-CREF is eligible to work with a TIAA-CREF Financial Consultant, and receive one-on-one objective retirement plan advice and related

56

Standard Steam Trust LLC | Open Energy Information  

Open Energy Info (EERE)

Trust LLC Trust LLC Jump to: navigation, search Name Standard Steam Trust LLC Place Denver, Colorado Sector Geothermal energy Product Subsidiary of Denver-based geothermal project developer, Terra Caliente. Coordinates 39.74001°, -104.992259° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":39.74001,"lon":-104.992259,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

57

Quercus Trust David Gelbaum Private investor | Open Energy Information  

Open Energy Info (EERE)

Quercus Trust David Gelbaum Private investor Quercus Trust David Gelbaum Private investor Jump to: navigation, search Name Quercus Trust / David Gelbaum (Private investor) Place Newport Beach, California Zip 92660 Product David Gelbaum is an angel investor who runs the Quercus Trust, a major donor to conservation advocacy and enviromental organisations, and takes passive stakes in public companies. References Quercus Trust / David Gelbaum (Private investor)[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Quercus Trust / David Gelbaum (Private investor) is a company located in Newport Beach, California . References ↑ "Quercus Trust / David Gelbaum (Private investor)" Retrieved from "http://en.openei.org/w/index.php?title=Quercus_Trust_David_Gelbaum_Private_investor&oldid=350147"

58

Trust enhanced ubiquitous payment without too much privacy loss  

Science Conference Proceedings (OSTI)

Computational models of trust have been proposed for use in ubicomp environments for deciding whether to allow customers to pay with an e-purse or not. In order to build trust in a customer, a means to link transactions using the same e-purse is required. ... Keywords: context, payment, privacy, trust, ubicomp

Jean-Marc Seigneur; Christian Damsgaard Jensen

2004-03-01T23:59:59.000Z

59

Information quality, trust, and risk perceptions in electronic data exchanges  

Science Conference Proceedings (OSTI)

This study investigates the influence of information quality, trust and risk perceptions on the expected transaction performance of inter-organizational data exchanges and on the user intent to continue using the exchange. This study provides empirical ... Keywords: Competence-trust, Electronic transaction performance, Exchange-risk, Goodwill-trust, Information quality, Intent to use, Performance-risk

Andreas I. Nicolaou; Mohammed Ibrahim; Eric Van Heck

2013-01-01T23:59:59.000Z

60

Disability Employment Program  

Science Conference Proceedings (OSTI)

... 301-975-8725 Disability Program Manager: Aimee Generoso-Nguyen 301-945-2043 Email: aimee.generoso-nguyen@nist.gov. Resources: ...

2012-07-30T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

A Welfarist Approach to Disabilities  

E-Print Network (OSTI)

toLiveintheWorld:TheDisabledintheLawofTorts,54Id. Thenon?workersaredisabledadultchildren,widows,orminor childrenofdisabledworkers. Therefore,some

Weisbach, David A.

2007-01-01T23:59:59.000Z

62

Energy Saving Trust EST | Open Energy Information  

Open Energy Info (EERE)

Saving Trust EST Saving Trust EST Jump to: navigation, search Name Energy Saving Trust (EST) Place London, United Kingdom Zip SW1H 9BP Sector Carbon Product The Energy Saving Trust's goal is to achieve the sustainable and efficient use of energy, and to cut carbon dioxide emissions, one of the key contributors to climate change. Coordinates 51.506325°, -0.127144° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":51.506325,"lon":-0.127144,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

63

Hardware Security Device Facilitated Trusted Energy Services  

Science Conference Proceedings (OSTI)

We report on our experiences in developing a hardware based security solution for a novel, smart-grid enabled energy services system. In this paper, we first give a background to a new energy services model and then describe how we incorporated a CSIRO ... Keywords: accountability, authentication, energy services, privacy, security, trusted computing, trustworthy systems

John J. Zic; Martin Groot; Dongxi Liu; Julian Jang; Chen Wang

2012-08-01T23:59:59.000Z

64

Security and trust in virtual healthcare communities  

Science Conference Proceedings (OSTI)

The main purpose of a virtual healthcare community is to enforce members' collaboration and allow them collectively conduct health care activities. Patient monitoring and medical consultation and support are the most popular activities inside health ... Keywords: health care, security, teleconsultation, trust, virtual communities

Anargyros Chryssanthou; Iraklis Varlamis; Charikleia Latsiou

2009-06-01T23:59:59.000Z

65

File:03ORBEasementsOnTrustAndNonTrustLand (2).pdf | Open Energy Information  

Open Energy Info (EERE)

ORBEasementsOnTrustAndNonTrustLand (2).pdf ORBEasementsOnTrustAndNonTrustLand (2).pdf Jump to: navigation, search File File history File usage File:03ORBEasementsOnTrustAndNonTrustLand (2).pdf Size of this preview: 463 × 599 pixels. Other resolution: 464 × 600 pixels. Full resolution ‎(1,275 × 1,650 pixels, file size: 33 KB, MIME type: application/pdf) File history Click on a date/time to view the file as it appeared at that time. Date/Time Thumbnail Dimensions User Comment current 12:59, 28 September 2012 Thumbnail for version as of 12:59, 28 September 2012 1,275 × 1,650 (33 KB) Dklein2012 (Talk | contribs) 12:57, 28 September 2012 Thumbnail for version as of 12:57, 28 September 2012 1,275 × 1,650 (33 KB) Dklein2012 (Talk | contribs) You cannot overwrite this file. Edit this file using an external application (See the setup

66

Mentoring experiences of disabled employees.  

E-Print Network (OSTI)

??The disability literature suggests the use of mentoring programs in order to help the advancement opportunities and integration of disabled employees in the workplace. However, (more)

Kimbrough, Andrea Brinley

2007-01-01T23:59:59.000Z

67

An efficient and versatile approach to trust and reputation using hierarchical Bayesian modelling  

Science Conference Proceedings (OSTI)

In many dynamic open systems, autonomous agents must interact with one another to achieve their goals. Such agents may be self-interested and, when trusted to perform an action, may betray that trust by not performing the action as required. Due to the ... Keywords: Group-based trust, Probabilistic trust, Reputation, Trust

W.T. Luke Teacy; Michael Luck; Alex Rogers; Nicholas R. Jennings

2012-12-01T23:59:59.000Z

68

Energy Trust - Small Wind Incentive Program (Oregon) State Rebate...  

Open Energy Info (EERE)

Data Page Edit with form History Share this page on Facebook icon Twitter icon Energy Trust - Small Wind Incentive Program (Oregon) State Rebate Program This is the...

69

Spent Fuel Disposal Trust Fund (Maine) | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Program Type Safety and Operational Guidelines Any licensee operating a nuclear power plant in this State shall establish a segregated Spent Nuclear Fuel Disposal Trust Fund...

70

A Filter Active-Set Trust-Region Method  

E-Print Network (OSTI)

Sep 10, 2007... Computing Research, Office of Science, U.S. Department of Energy, .... additional ellipsoidal trust-region constraint d + dc G ? ?2 (for G...

71

Master Limited Partnerships and Real Estate Investment Trusts...  

NLE Websites -- All DOE Office Websites (Extended Search)

and Real Estate Investment Trusts: Opportunities and Potential Complications for Renewable Energy David Feldman and Edward Settle Technical Report NRELTP-6A20-60413 November...

72

White House Launches Plan to Create a Trusted 'Identity ...  

Science Conference Proceedings (OSTI)

White House Launches Plan to Create a Trusted 'Identity Ecosystem' for On-Line Commerce. From NIST Tech Beat: April 26, 2011. ...

2011-04-26T23:59:59.000Z

73

Trust Anchor Lifecycle Attack Protection | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

secure software providing independent testing, monitoring, and control of energy control system component operation Trust Anchor Lifecycle Attack Protection More Documents...

74

Cyberspace Policy Review: Assuring a Trusted and Resilient Information and  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Cyberspace Policy Review: Assuring a Trusted and Resilient Cyberspace Policy Review: Assuring a Trusted and Resilient Information and Communications Infrastructure Cyberspace Policy Review: Assuring a Trusted and Resilient Information and Communications Infrastructure The review team of government cybersecurity experts engaged and received input from a broad cross-section of industry, academia, the civil liberties and privacy communities, State governments, international partners, and the Legislative and Executive Branches. This paper summarizes the review team's conclusions and outlines the beginning of the way forward towards a reliable, resilient, trustworthy digital infrastructure for the future Cyberspace Policy Review: Assuring a Trusted and Resilient Information and Communications Infrastructure More Documents & Publications

75

Disability Employment | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Disability Employment Disability Employment Disability Employment DOE's Statement on Disability Hiring The U. S. Department of Energy is committed to fostering a culture of diversity. We recognize that individuals with disabilities are an untapped talent pool and possess skills and competencies that the Department needs to remain competitive. The Department of Energy (DOE) is fully committed to improving our efforts to employ Federal workers with disabilities and targeted disabilities through increased recruiting, hiring, and retention. Although millions of people with disabilities work, two-thirds of this labor pool is still untapped. Recruiting and retaining workers with disabilities is one strategy to counter the effects of the aging and shrinking workforce. This untapped labor pool can offer a source of skilled employees and can

76

Report: Public Trust in Higher Education and A Media Review of Press Articles in California  

E-Print Network (OSTI)

independence of higher education from federal edicts.news). PUBLIC TRUST IN HIGHER EDUCATION AND A MEDIA REVIEWPublic Trust in Higher Education and A Media Review of Press

Fox, Warren H.; Earl-Novell, Sarah L.

2004-01-01T23:59:59.000Z

77

Essays on disability and employment  

E-Print Network (OSTI)

This dissertation consists of three essays which examine the impact of public policy on labor market outcomes of those with disabilities. The first essay analyzes a microlending program for people with disabilities in ...

Thompkins, Allison V. (Allison Victoria)

2011-01-01T23:59:59.000Z

78

Key figure impact in trust-enhanced recommender systems  

Science Conference Proceedings (OSTI)

Collaborative filtering recommender systems are typically unable to generate adequate recommendations for newcomers. Empirical evidence suggests that the incorporation of a trust network among the users of a recommender system can significantly help ... Keywords: Trust network, cold start problem, recommender system, social network analysis

Patricia Victor; Chris Cornelis; Martine De Cock; Ankur M. Teredesai

2008-04-01T23:59:59.000Z

79

Some thoughts on using argumentation to handle trust  

Science Conference Proceedings (OSTI)

This paper describes some of our recent work on using argumentation to handle information about trust. We first discuss the importance of trust in computer science in general and in multi-agent systems in particular.We then describe the setting of our ...

Simon Parsons; Yuqing Tang; Kai Cai; Elizabeth Sklar; Peter McBurney

2011-07-01T23:59:59.000Z

80

Hybrid trust and reputation management for sensor networks  

Science Conference Proceedings (OSTI)

Wireless sensor networks are characterised by the distributed nature of their operation and the resource constraints on the nodes. Trust management schemes that are targeted at sensor networks need to be lightweight in terms of computational and communication ... Keywords: Reputation management, Sensor networks, Trust establishment

Efthimia Aivaloglou; Stefanos Gritzalis

2010-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

CASE STUDY -ELECTRIC UTILITY RESTRUCTURING -MASSACHUSETTS RENEWABLE ENERGY TRUST FUND  

E-Print Network (OSTI)

CASE STUDY - ELECTRIC UTILITY RESTRUCTURING - MASSACHUSETTS RENEWABLE ENERGY TRUST FUND John A or not WTE will be considered a "renewable energy" source with respect to mandated fractions of state. This discussion will provide a brief history of the Massachusetts, Renewable Energy Trust Fund (RETF), delineate

Columbia University

82

Trust network-based filtering of aggregated claims  

Science Conference Proceedings (OSTI)

On the semantic web, assertions may be aggregated from many sources, those aggregations filtered, reasoned over, aggregated with other aggregators, displayed, scraped, extracted, recombined, and otherwise processed without significant human oversight. ... Keywords: aggregated claims, assertions, information filtering, knowledge bases, ontologies, semantic web, social networks, source reputation, trust networks, trust rating, trustworthiness

Jennifer Golbeck; Bijan Parsia

2006-01-01T23:59:59.000Z

83

Effects of innovativeness and trust on web survey participation  

Science Conference Proceedings (OSTI)

Responding to suggestions of prior research for examining the psychological constructs involved in a decision for or against participation in web surveys, this paper investigated the effects of trust in sponsor and personal innovativeness on potential ... Keywords: Personal innovativeness, Response rate, Theory of planned behavior (TPB), Trust, Web survey

Jiaming Fang; Peiji Shao; George Lan

2009-01-01T23:59:59.000Z

84

Air Conditioning and lungs  

NLE Websites -- All DOE Office Websites (Extended Search)

Air Conditioning and lungs Name: freeman Status: NA Age: NA Location: NA Country: NA Date: Around 1993 Question: What affect does air conditioning have upon the lungs of the...

85

Announcing the Clean Energy Trust Semifinalists | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Announcing the Clean Energy Trust Semifinalists Announcing the Clean Energy Trust Semifinalists Announcing the Clean Energy Trust Semifinalists January 24, 2012 - 6:54pm Addthis Matthew Loveless Matthew Loveless Data Integration Specialist, Office of Public Affairs On January 6th, the Clean Energy Trust announced the semifinalists for its inaugural student clean energy challenge. Semifinalists were chosen from more than 40 innovative clean energy business plans submitted from eight Midwestern states. The 16 semifinalist teams represent five states (Illinois, Indiana, Michigan, Missouri, and Ohio) and 11 universities, with the most teams coming from Purdue University (four teams) and Northwestern University (three teams). Within the submissions, Clean Energy Trust reviewers saw a broad assortment of undergraduate and graduate students, male and female

86

Announcing the Clean Energy Trust Semifinalists | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Announcing the Clean Energy Trust Semifinalists Announcing the Clean Energy Trust Semifinalists Announcing the Clean Energy Trust Semifinalists January 24, 2012 - 6:54pm Addthis Matthew Loveless Matthew Loveless Data Integration Specialist, Office of Public Affairs On January 6th, the Clean Energy Trust announced the semifinalists for its inaugural student clean energy challenge. Semifinalists were chosen from more than 40 innovative clean energy business plans submitted from eight Midwestern states. The 16 semifinalist teams represent five states (Illinois, Indiana, Michigan, Missouri, and Ohio) and 11 universities, with the most teams coming from Purdue University (four teams) and Northwestern University (three teams). Within the submissions, Clean Energy Trust reviewers saw a broad assortment of undergraduate and graduate students, male and female

87

Toward Trust and Reputation Based Web Service Selection: A Survey  

E-Print Network (OSTI)

Using trust and reputation mechanisms offers a promising way to solve the web service selection problem. The investigation of trust and reputation systems in other areas can provide valuable observations and approaches that can be used in web service systems. Therefore, this paper presents a systematic review of various trust and reputation systems and proposes a typology to classify them from three aspects, centralized vs. decentralized, persons/agents vs. resources, global vs. personalized. These aspects are important not only in that they clarify the difference between various existing trust and reputation systems, but also in that they point out the potential research directions for using trust and reputation in web services and provide some reference systems for them.

Yao Wang; Julita Vassileva

2007-01-01T23:59:59.000Z

88

Trust Management Considerations For the Cooperative Infrastructure Defense Framework: Trust Relationships, Evidence, and Decisions  

Science Conference Proceedings (OSTI)

Cooperative Infrastructure Defense (CID) is a hierarchical, agent-based, adaptive, cyber-security framework designed to collaboratively protect multiple enclaves or organizations participating in a complex infrastructure. CID employs a swarm of lightweight, mobile agents called Sensors designed to roam hosts throughout a security enclave to find indications of anomalies and report them to host-based Sentinels. The Sensors findings become pieces of a larger puzzle, which the Sentinel puts together to determine the problem and respond per policy as given by the enclave-level Sergeant agent. Horizontally across multiple enclaves and vertically within each enclave, authentication and access control technologies are necessary but insufficient authorization mechanisms to ensure that CID agents continue to fulfill their roles in a trustworthy manner. Trust management fills the gap, providing mechanisms to detect malicious agents and offering more robust mechanisms for authorization. This paper identifies the trust relationships throughout the CID hierarchy, the types of trust evidence that could be gathered, and the actions that the CID system could take if an entity is determined to be untrustworthy.

Maiden, Wendy M.

2009-12-01T23:59:59.000Z

89

Computational trust and reputation models for open multi-agent systems: a review  

Science Conference Proceedings (OSTI)

In open environments, agents depend on reputation and trust mechanisms to evaluate the behavior of potential partners. The scientific research in this field has considerably increased, and in fact, reputation and trust mechanisms have been already considered ... Keywords: Cognitive trust and reputation, Computational trust and reputation models, Multiagent systems

Isaac Pinyol; Jordi Sabater-Mir

2013-06-01T23:59:59.000Z

90

Towards pre-standardization of trust and reputation models for distributed and heterogeneous systems  

Science Conference Proceedings (OSTI)

Different trust and/or reputation models have arisen in the last few years. All of them have certain key processes in common such as scoring, ranking, rewarding, punishing or gathering behavioral information. However, there is not a standardization effort ... Keywords: Trust and reputation management, Trust and reputation models taxonomy, Trust and reputation standardization

Flix Gmez Mrmol; Gregorio Martnez Prez

2010-06-01T23:59:59.000Z

91

Trust factors influencing the adoption of internet-based interorganizational systems  

Science Conference Proceedings (OSTI)

This study aims to empirically examine the trust factors that affect the adoption of Internet-based interorganizational systems (IIOS). A trust model with five trust factors is constructed. The model is tested using data gathered from 295 practitioners. ... Keywords: Electronic supply chain management, Information systems, Internet-based interorganizational systems, Trust

Ivan K. W. Lai; Viny W. L. Tong; Donny C. F. Lai

2011-01-01T23:59:59.000Z

92

Renewable Energy Resources Trust Fund | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

You are here You are here Home » Renewable Energy Resources Trust Fund Renewable Energy Resources Trust Fund < Back Eligibility Commercial Industrial Institutional Residential Utility Savings Category Bioenergy Alternative Fuel Vehicles Hydrogen & Fuel Cells Buying & Making Electricity Water Solar Heating & Cooling Commercial Heating & Cooling Heating Water Heating Wind Program Info State Illinois Program Type Public Benefits Fund Provider Illinois Department of Commerce and Economic Opportunity Illinois's 1997 electric-industry restructuring legislation created separate public benefits funds that support renewable energy and residential [http://www.dsireusa.org/library/includes/incentive2.cfm?Incentive_Code=I... energy efficiency]. The Renewable Energy Resources Trust Fund (RERTF)

93

Disabling Radiological Dispersal Terror  

SciTech Connect

Terror resulting from the use of a radiological dispersal device (RDD) relies upon an individual's lack of knowledge and understanding regarding its significance. Disabling this terror will depend upon realistic reviews of the current conservative radiation protection regulatory standards. It will also depend upon individuals being able to make their own informed decisions merging perceived risks with reality. Preparation in these areas will reduce the effectiveness of the RDD and may even reduce the possibility of its use.

Hart, M

2002-11-08T23:59:59.000Z

94

Section 28 Trust Wind Farm | Open Energy Information  

Open Energy Info (EERE)

Section 28 Trust Wind Farm Section 28 Trust Wind Farm Jump to: navigation, search Name Section 28 Trust Wind Farm Facility Section 28 Trust Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Energy Purchaser Southern California Edison Co Location San Gorgonio CA Coordinates 33.9095°, -116.734° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.9095,"lon":-116.734,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

95

Efficiency Maine Trust - Renewable Resource Fund | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Efficiency Maine Trust - Renewable Resource Fund Efficiency Maine Trust - Renewable Resource Fund Efficiency Maine Trust - Renewable Resource Fund < Back Eligibility Institutional Nonprofit Residential Rural Electric Cooperative Schools Savings Category Bioenergy Alternative Fuel Vehicles Hydrogen & Fuel Cells Buying & Making Electricity Water Solar Wind Program Info State Maine Program Type Public Benefits Fund Maine's public benefits fund for renewable energy was established as part of the state's electric-industry restructuring legislation, enacted in May 1997. The law directed the Maine Public Utilities Commission (PUC) to develop a voluntary program allowing customers to contribute to a fund that supports renewable-energy projects. This fund was originally known as the Renewable Resource Fund (now it is part of Efficiency Maine Trust).

96

Big Sky Trust Fund (Montana) | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Big Sky Trust Fund (Montana) Big Sky Trust Fund (Montana) Big Sky Trust Fund (Montana) < Back Eligibility Commercial Local Government Tribal Government Savings Category Alternative Fuel Vehicles Hydrogen & Fuel Cells Buying & Making Electricity Water Wind Home Weatherization Solar Program Info Start Date 2005 State Montana Program Type Grant Program Provider Montana Department of Commerce The Big Sky Trust Fund reimburses expenses incurred in the purchase, leasing, or relocation of real assets for direct use of the assisted business or employee training costs. A local or tribal government on behalf of any business may apply. The funding limit of the program is $5,000 per new qualifying job created or $7,500 per qualifying job created in a high poverty county. A dollar for dollar match (or 50% match in a high poverty

97

Trusted source translation of a total function language  

Science Conference Proceedings (OSTI)

We present a trusted source translator that transforms total functions defined in the specification language of the HOL theorem prover to simple intermediate code. This translator eliminates polymorphism by code specification, removes higher-order functions ...

Guodong Li; Konrad Slind

2008-03-01T23:59:59.000Z

98

Trust based app marketing : design, implementation and evaluation  

E-Print Network (OSTI)

A trust-based marketing application is a web or mobile app which provides a utility to the consumer that is not directly linked to purchasing products or services from the company. In this thesis, I explore the efficacy ...

Hon, Keone D. (Keone David)

2011-01-01T23:59:59.000Z

99

Executive Director for Operations PROPOSED RULE ON DECOMMISSIONING TRUST PROVISIONS  

E-Print Network (OSTI)

To request Commission approval to publish a proposed rule in the Federal Register on decommissioning trust agreement requirements. BACKGROUND: The staff presented a rulemaking plan (SECY-00-0002) to the Commission on December 30, 1999. The plan discussed two actions relating to amending nuclear power reactor decommissioning trust provisions i.e., to amend 10 CFR 50.75 and revise Regulatory Guide 1.159. Subsequently, in a February 9, 2000, staff requirements memorandum (SRM) to the Executive Director for Operations (Attachment 1), the Commission authorized the staff to proceed with the rulemaking plan. Further, the Commission instructed the staff that any specific trust fund terms and conditions necessary to protect the funds fully should be set out in the rule itself, not in the regulatory guide. Sample language for trust agreements consistent with the terms and conditions within the rule may be provided within the associated regulatory guide. The attached Federal Register notice (FRN) responds to the SRM. DISCUSSION: Contact:

William D. Travers; Brian Richter

2001-01-01T23:59:59.000Z

100

Second-Order-Cone Constraints for Extended Trust-Region ...  

E-Print Network (OSTI)

Mar 4, 2011 ... Keywords: trust-region subproblem, second-order cone ..... (Note that the proof to this point does not use the assumption X11 + lu = (l + u)x1.

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Executive Director for Operations FINAL RULE ON DECOMMISSIONING TRUST PROVISIONS  

E-Print Network (OSTI)

To request Commission approval to publish in the Federal Register a final rule on decommissioning trust provisions. BACKGROUND: The staff submitted Proposed Rule on Decommissioning Trust Provisions, (SECY-01-0049) to the Commission on March 23, 2001. The Commission issued a staff requirements memorandum (SRM) on April 20, 2001, approving publication of the proposed rule. The proposed rule was published in the Federal Register on May 30, 2001 (66 FR 29244). The staff issued

William D. Travers; Brian Richter Nrr/drip/rprp

2002-01-01T23:59:59.000Z

102

Disability Insurance: Protect Your Most Valuable Asset  

E-Print Network (OSTI)

An 18% chance of becoming disabled for 3 months or longera 41% chance of becoming disabled for 3 months or longer. AA 13% chance of becoming disabled for 3 months or longer

Borgia, Andy G

2013-01-01T23:59:59.000Z

103

Disability Employment Awareness Month | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

of the world. During National Disability Employment Awareness Month, we recognize the skills that people with disabilities bring to our workforce, and we rededicate ourselves to...

104

Disability Employment POCs | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Disability Employment POCs Disability Employment POCs NAME ORGANIZATION PH EMAL Donna Friend Headquarters Policy 202-586-5880 donna.friend@hq.doe.gov Kenneth Fields Headquarters...

105

Americans with Disabilities Act Signed (1990)  

Energy.gov (U.S. Department of Energy (DOE))

The Americans with Disabilities Act of 1990 (ADA) prohibits discrimination and ensures equal opportunity for persons with disabilities in employment, State and local government services, public...

106

Universal service and disabled people  

Science Conference Proceedings (OSTI)

The EU regulatory framework enacted 25 May 2011 has the objective to provide functionally equal access to telecommunication services for disabled persons. What are the rules, who are the target groups, and what obstacles do they face when using various ... Keywords: Disabled people, European regulation, Relay services, Universal service

Nico van Eijk; Joost Poort

2012-03-01T23:59:59.000Z

107

The impact of consumer trust on attitudinal loyalty and purchase intentions in B2C e-marketplaces: Intermediary trust vs. seller trust  

Science Conference Proceedings (OSTI)

The online merchant of an e-marketplace consists of an intermediary, providing the market infrastructure, and the community of sellers conducting business within that infrastructure. Typically, consumers willingly buy from unknown sellers within an e-marketplace, ... Keywords: Attitudinal loyalty, B2C e-marketplace, Consumer trust, Intermediary, Purchase intentions

Ilyoo B. Hong; Hwihyung Cho

2011-10-01T23:59:59.000Z

108

Requirements Definition for ORNL Trusted Corridors Project  

SciTech Connect

The ORNL Trusted Corridors Project has several other names: SensorNet Transportation Pilot; Identification and Monitoring of Radiation (in commerce) Shipments (IMR(ic)S); and Southeastern Transportation Corridor Pilot (SETCP). The project involves acquisition and analysis of transportation data at two mobile and three fixed inspection stations in five states (Kentucky, Mississippi, South Carolina, Tennessee, and Washington DC). Collaborators include the State Police organizations that are responsible for highway safety, law enforcement, and incident response. The three states with fixed weigh-station deployments (KY, SC, TN) are interested in coordination of this effort for highway safety, law enforcement, and sorting/targeting/interdiction of potentially non-compliant vehicles/persons/cargo. The Domestic Nuclear Detection Office (DNDO) in the U.S. Department of Homeland Security (DHS) is interested in these deployments, as a Pilot test (SETCP) to identify Improvised Nuclear Devices (INDs) in highway transport. However, the level of DNDO integration among these state deployments is presently uncertain. Moreover, DHS issues are considered secondary by the states, which perceive this work as an opportunity to leverage these (new) dual-use technologies for state needs. In addition, present experience shows that radiation detectors alone cannot detect DHS-identified IND threats. Continued SETCP success depends on the level of integration of current state/local police operations with the new DHS task of detecting IND threats, in addition to emergency preparedness and homeland security. This document describes the enabling components for continued SETCP development and success, including: sensors and their use at existing deployments (Section 1); personnel training (Section 2); concept of operations (Section 3); knowledge discovery from the copious data (Section 4); smart data collection, integration and database development, advanced algorithms for multiple sensors, and network communications (Section 5); and harmonization of local, state, and Federal procedures and protocols (Section 6).

Walker, Randy M [ORNL; Hill, David E [ORNL; Smith, Cyrus M [ORNL; DeNap, Frank A [ORNL; White, James D [ORNL; Gross, Ian G [ORNL; Gorman, Bryan L [ORNL; Hively, Lee M [ORNL; Abercrombie, Robert K [ORNL

2008-02-01T23:59:59.000Z

109

Developed for Trusted Computing Group, www.trustedcomputinggroup.org Subj: SPC-3 Create well known LUN for trusted commands  

E-Print Network (OSTI)

This document presents a proposal to define a well known logical unit to process trusted commands. This feature is intended for use by array controllers and other multi-LUN devices, but may be implemented by single LUN devices as well. This proposal requires use of trusted commands described in related T10 proposal 05-157. Rev. 1: Change name of the well known LUN from security commands to trusted commands. Page 1 of 2Document T10/05-252 rev. 1 Add changes to table 333 in clause 8.1 as follows: (additions are underlined) 8.1 Model for well known logical units Well known logical units are addressed using the well known logical unit addressing method of extended logical unit addressing (see SAM-3). Each well known logical unit has a well known logical unit number (W-LUN) as shown in table 333. Table 333 Well known logical unit numbers W-LUN Description Reference 0h Reserved 1h REPORT LUNS well known logical unit 8.2 2h ACCESS CONTROLS well known logical unit 8.3 3h REPORT TARGET PAGES well known logical unit 8.4 4h TRUSTED COMMANDS well known logical unit 8.5 5h- FFh Reserved Add new clause 8.5 as follows: 8.5 TRUSTED COMMANDS well known logical unit The TRUSTED COMMANDS well known logical unit shall only process the commands listed in table xx. If a command is received by the TRUSTED COMMANDS well known logical unit that is not listed in table xx, then the command shall be terminated with CHECK CONDITION status, with the sense key set to ILLEGAL REQUEST, and the additional sense code set to INVALID

unknown authors

2005-01-01T23:59:59.000Z

110

Oregon Wave Energy Trust OWET | Open Energy Information  

Open Energy Info (EERE)

Trust OWET Trust OWET Jump to: navigation, search Name Oregon Wave Energy Trust (OWET) Place Portland, Oregon Zip 97207 Product String representation "The Oregon Wave ... rgy generation." is too long. Coordinates 45.511795°, -122.675629° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":45.511795,"lon":-122.675629,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

111

Massachusetts Renewable Energy Trust MRET | Open Energy Information  

Open Energy Info (EERE)

Trust MRET Trust MRET Jump to: navigation, search Name Massachusetts Renewable Energy Trust (MRET) Place Westborough, Massachusetts Zip MA 01581 Sector Renewable Energy Product USD 150m umbrella programme set up by the Legislature in 1998 to promote electric utility industry restructuring and the development of renewable energy in Massachusetts. Coordinates 42.283096°, -71.600318° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":42.283096,"lon":-71.600318,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

112

Colorado State Bank and Trust | Open Energy Information  

Open Energy Info (EERE)

Trust Trust Jump to: navigation, search Name Colorado State Bank and Trust Place Denver, Colorado Zip 80202 Sector Renewable Energy Product Leasing and lending for renewable projects Coordinates 39.74001°, -104.992259° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":39.74001,"lon":-104.992259,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

113

Roadmap to a Sustainable Structured Trusted Employee Program  

SciTech Connect

Organizations (facility, regulatory agency, or country) have a compelling interest in ensuring that individuals who occupy sensitive positions affording access to chemical biological, radiological and nuclear (CBRN) materials facilities and programs are functioning at their highest level of reliability. Human reliability and human performance relate not only to security but also focus on safety. Reliability has a logical and direct relationship to trustworthiness for the organization is placing trust in their employees to conduct themselves in a secure, safe, and dependable manner. This document focuses on providing an organization with a roadmap to implementing a successful and sustainable Structured Trusted Employee Program (STEP).

Coates, Cameron W [ORNL; Eisele, Gerhard R [ORNL

2013-08-01T23:59:59.000Z

114

Recruiting People with Disabilities | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Disability Employment » Recruiting People with Disability Employment » Recruiting People with Disabilities Recruiting People with Disabilities Many of the following websites provide free services for employers: AbilityJobs.com Largest stand-alone resume bank specifically for job seekers with disabilities. Employers can post job opportunities or search resumes to find qualified persons with disabilities. Careers and the Disabled Career Expo for People with Disabilities Brings industry and government together with people with disabilities who are entry level and professionals in all career disciplines. Career Opportunities for Students with Disabilities (COSD) A unique and dynamic national professional association comprised of more than 600 colleges and universities and over 500 major national employers.

115

Age and Trust in the Internet: The Centrality of Experience and Attitudes Toward Technology in Britain  

Science Conference Proceedings (OSTI)

The authors describe changes in user's trust on the Internet in Britain between 2003 and 2009, and show how the relationship between age and trust can be explained by a combination of experience with the Internet and general attitudes toward technology. ... Keywords: Internet, replication, risk, technology attitudes, trust

Grant Blank; William H. Dutton

2012-05-01T23:59:59.000Z

116

Energy consumption analysis of reputation-based trust management schemes of wireless sensor networks  

Science Conference Proceedings (OSTI)

Energy consumption is one of the most important parameters for evaluation of a scheme proposed for WSNs because of their resource constraint nature. Comprehensive comparative analysis of proposed reputation-based trust management schemes of WSNs from ... Keywords: reputation, sensor networks, trust evaluation, trust management

Riaz Ahmed Shaikh; Young-Koo Lee; Sungyoung Lee

2009-02-01T23:59:59.000Z

117

The Role of Communication and Trust in Global Virtual Teams: A Social Network Perspective  

Science Conference Proceedings (OSTI)

The importance of communication and trust in the context of global virtual teams has been noted and reiterated in the information systems (IS) literature. Yet precisely how communication and trust influence certain outcomes within virtual teams remains ... Keywords: Communication, Distributed Teams, Global Virtual Teams, Hybrid Teams, Individual Performance, Mediation, Networked Individualism, Social Network Analysis, Trust

Saonee Sarker; Manju Ahuja; Suprateek Sarker; Sarah Kirkeby

2011-07-01T23:59:59.000Z

118

A model of a trust-based recommendation system on a social network  

Science Conference Proceedings (OSTI)

In this paper, we present a model of a trust-based recommendation system on a social network. The idea of the model is that agents use their social network to reach information and their trust relationships to filter it. We investigate how the dynamics ... Keywords: Recommender system, Social network, Trust

Frank Edward Walter; Stefano Battiston; Frank Schweitzer

2008-02-01T23:59:59.000Z

119

A software-based trust framework for distributed industrial management systems  

Science Conference Proceedings (OSTI)

One of the major problems in industrial security management is that most organizations or enterprises do not provide adequate guidelines or well-defined policy with respect to trust management, and trust is still an afterthought in most security engineering ... Keywords: Distributed industrial management systems, Security engineering, Trust management

Sheikh I. Ahamed; Mohammad Zulkernine; Steve Wolfe

2007-10-01T23:59:59.000Z

120

Disabled Veterans Affirmative Action Plan | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Disabled Veterans Affirmative Action Plan Disabled Veterans Affirmative Action Plan Guide for the Disabled Veterans' Affirmative Action Program (DVAAP) 2013 DVAAP Responsible...

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

The Access Almanac: Ending the Abuse of Disabled Parking Placards  

E-Print Network (OSTI)

ALMANAC Ending the Abuse of Disabled Parking Placards DONALDtell an anecdote about disabled placard abuse. One of minenoticing that cars with disabled placards occupied almost

Shoup, Donald

2011-01-01T23:59:59.000Z

122

Voice pharming attack and the trust of VoIP  

Science Conference Proceedings (OSTI)

Voice communication is fundamental to the normal operation of our society. The general public have put a lot of trust in voice communication and they have been relying on it for many critical and sensitive information exchange (e.g., emergency 911 calls, ...

Xinyuan Wang; Ruishan Zhang; Xiaohui Yang; Xuxian Jiang; Duminda Wijesekera

2008-09-01T23:59:59.000Z

123

Risky trust: risk-based analysis of software systems  

Science Conference Proceedings (OSTI)

Measuring the security of a software system is a difficult problem. This paper presents a model using common security concepts to evaluate the security of a system under design. After providing definitions for all relevant concepts and formalizing some ... Keywords: distrust, risk analysis, trust

Zaid Dwaikat; Francesco Parisi-Presicce

2005-07-01T23:59:59.000Z

124

Protecting clients from insider attacks on trust accounts  

Science Conference Proceedings (OSTI)

Law firms are no exception to the trend towards computerized information infrastructures, particularly because the very nature of their business is collecting and storing highly confidential client data. One area of activity which has come under intense ... Keywords: Fraud, IT security, Trust account

Sameera Mubarak; Jill Slay

2009-11-01T23:59:59.000Z

125

3 Year Review of Genetics White Paper Wellcome Trust Response  

E-Print Network (OSTI)

3 Year Review of Genetics White Paper Wellcome Trust Response 1 November 2006 Introduction 1 since publication of the 2003 Genetics White Paper (the White Paper). Key areas for improvement. However, one area that was not mentioned in the original White Paper that could have a major impact

Rambaut, Andrew

126

Building trust and commitment in a global organisation  

Science Conference Proceedings (OSTI)

How do managers adapt to structural conditions and cultures in different locations where they do business, as they attempt to shape organisational culture and practices? This paper reports on a case study of 'EmergeInc', a (disguised) ... Keywords: commitment building, global management, globalisation, online information, organisational culture, organisational structure, structural features, trust building

Janis L. Gogan

2008-06-01T23:59:59.000Z

127

Interconnected networks and the governance of risk and trust  

Science Conference Proceedings (OSTI)

Interconnected networks constitute the backbone of our society and bring many advantages to our daily life and activities. At the same time, however, our dependence on these networks and the fact that they are all interconnected makes our society vulnerable. ... Keywords: Risk, governance, interconnection, networks, trust

Victor Bekkers; Marcel Thaens

2005-04-01T23:59:59.000Z

128

Corporate Social Responsibility and Competitive Advantage: Overcoming the Trust Barrier  

Science Conference Proceedings (OSTI)

This research builds on the complementary corporate social responsibility (CSR) literatures in strategy and marketing to provide insight into the efficacy of CSR as a challenger's competitive weapon against a market leader. Through an investigation of ... Keywords: affective trust, challenger brand, competitive strategy, corporate social responsibility

Shuili Du; C. B. Bhattacharya; Sankar Sen

2011-09-01T23:59:59.000Z

129

Trust-Assisted Handover Approach in Hybrid Wireless Networks  

Science Conference Proceedings (OSTI)

In Next-Generation (NG) hybrid wireless networks, Mobile-Controlled Handover (MCHO) is expected to be employed as the handover control mechanism, in contrast to Network-Controlled Handover (NCHO) used in homogeneous wireless networks. As more independent ... Keywords: Cross-layer handover, Hybrid wireless networks, Multi-operator, Security-enhanced QoS, Service roaming, Trust relation

Mo Li; Kumbesan Sandrasegaran; Tracy Tung

2010-02-01T23:59:59.000Z

130

Trust and nuanced profile similarity in online social networks  

Science Conference Proceedings (OSTI)

Online social networks, where users maintain lists of friends and express their preferences for items like movies, music, or books, are very popular. The Web-based nature of this information makes it ideal for use in a variety of intelligent systems ... Keywords: Social networks, recommender systems, trust

Jennifer Golbeck

2009-09-01T23:59:59.000Z

131

What instills trust? a qualitative study of phishing  

Science Conference Proceedings (OSTI)

This paper reports the highlights of a user study which gauges reactions to a variety of common "trust indicators" - such as logos, third party endorsements, and padlock icons - over a selection of authentic and phishing stimuli. In the course of the ... Keywords: authenticity, design, email, experiment, phishing, psychology, stimuli, think-aloud, user interface design, web pages

Markus Jakobsson; Alex Tsow; Ankur Shah; Eli Blevis; Youn-Kyung Lim

2007-02-01T23:59:59.000Z

132

Utah School and Institutional Trust Lands Administration | Open Energy  

Open Energy Info (EERE)

School and Institutional Trust Lands Administration School and Institutional Trust Lands Administration Jump to: navigation, search Logo: Utah School and Institutional Trust Lands Administration Name Utah School and Institutional Trust Lands Administration Address 675 East 500 South, Suite 500 Place Salt Lake City, Utah Zip 84102 Phone number 801.538.5100 Website http://trustlands.utah.gov/hom Coordinates 40.7544597°, -111.8767521° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.7544597,"lon":-111.8767521,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

133

Disabled legislators : disability and Irish colonial pathology in James Joyce's Ulysses.  

E-Print Network (OSTI)

??Why are there so many disabled characters in James Joyce's Ulysses? "Disabled Legislators" seeks to answer this question by exploring the variety and depth of (more)

Cormier, Andre.

2007-01-01T23:59:59.000Z

134

Developed for Trusted Computing Group, www.trustedcomputinggroup.org Subj: SPC-3 Create well known LUN for trusted commands  

E-Print Network (OSTI)

This document presents a proposal to define a well known logical unit to process trusted commands. This feature is intended for use by array controllers and other multi-LUN devices, but may be implemented by single LUN devices as well. This proposal requires use of trusted commands described in related T10 proposal 05-157. Rev. 1: Change name of the well known LUN from security commands to trusted commands. Rev. 2: Change name of the well known LUN from trusted to security protocol. Page 1 of 2Document T10/05-252 rev. 2 Add changes to table 333 in clause 8.1 as follows: (additions are underlined) 8.1 Model for well known logical units Well known logical units are addressed using the well known logical unit addressing method of extended logical unit addressing (see SAM-3). Each well known logical unit has a well known logical unit number (W-LUN) as shown in table 333. Table 333 Well known logical unit numbers W-LUN Description Reference 0h Reserved

unknown authors

2006-01-01T23:59:59.000Z

135

A Decisional Trust Implementation on a Maintenance System by the Means of Decisional DNA and Reflexive Ontologies  

Science Conference Proceedings (OSTI)

This article introduces the elements that we replaced together in order to achieve a decisional technology that can offer trust. Thus, we refer to it as Decisional Trust. Enhancing a decisional knowledge system with trust means that the user relies on ... Keywords: Decisional Trust, Decisional DNA, Reflexive Ontologies, Set of Experience Knowledge Structure, Experience Management

Cesar Sanin; Edward Szczerbicki

2008-12-01T23:59:59.000Z

136

Lung pair phantom  

DOE Patents (OSTI)

The present invention is a material and method of making the material that exhibits improved radiation attenuation simulation of real lungs, i.e., an ``authentic lung tissue`` or ALT phantom. Specifically, the ALT phantom is a two-part polyurethane medium density foam mixed with calcium carbonate, potassium carbonate if needed for K-40 background, lanthanum nitrate, acetone, and a nitrate or chloride form of a radionuclide. This formulation is found to closely match chemical composition and linear attenuation of real lungs. The ALT phantom material is made according to established procedures but without adding foaming agents or preparing thixotropic concentrate and with a modification for ensuring uniformity of density of the ALT phantom that is necessary for accurate simulation. The modification is that the polyurethane chemicals are mixed at a low temperature prior to pouring the polyurethane mixture into the mold.

Olsen, P.C.; Gordon, N.R.; Simmons, K.L.

1993-11-30T23:59:59.000Z

137

Lung pair phantom  

DOE Patents (OSTI)

The present invention is a material and method of making the material that exhibits improved radiation attenuation simulation of real lungs, i.e., an "authentic lung tissue" or ALT phantom. Specifically, the ALT phantom is a two-part polyurethane medium density foam mixed with calcium carbonate, potassium carbonate if needed for K-40 background, lanthanum nitrate, acetone, and a nitrate or chloride form of a radionuclide. This formulation is found to closely match chemical composition and linear attenuation of real lungs. The ALT phantom material is made according to established procedures but without adding foaming agents or preparing thixotropic concentrate and with a modification for ensuring uniformity of density of the ALT phantom that is necessary for accurate simulation. The modification is that the polyurethane chemicals are mixed at a low temperature prior to pouring the polyurethane mixture into the mold.

Olsen, Peter C. (West Richland, WA); Gordon, N. Ross (Kennewick, WA); Simmons, Kevin L. (Kennewick, WA)

1993-01-01T23:59:59.000Z

138

Disability trajectories : disabled youths' identity development, negotiation of experience and expectation, and sense of agency during transition  

E-Print Network (OSTI)

Press. Deal, M. (2003). Disabled people's attitudes towardB. (1995). Viewing the disabled child in the socioculturaldisabled? ..

Stolz, Suzanne Margaret

2010-01-01T23:59:59.000Z

139

Meridian Trust Wind Farm II | Open Energy Information  

Open Energy Info (EERE)

II II Jump to: navigation, search Name Meridian Trust Wind Farm II Facility Meridian Trust Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner NextEra Energy Resources Developer Kenetech Windpower Energy Purchaser Southern California Edison Co Location San Gorgonio CA Coordinates 33.9095°, -116.734° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.9095,"lon":-116.734,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

140

Meridian Trust Wind Farm I | Open Energy Information  

Open Energy Info (EERE)

I I Jump to: navigation, search Name Meridian Trust Wind Farm I Facility Meridian Trust Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner NextEra Energy Resources Developer Kenetech Windpower Energy Purchaser Southern California Edison Co Location San Gorgonio CA Coordinates 33.9095°, -116.734° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.9095,"lon":-116.734,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

RECIPIENT:Garfield County Fairgrounds Trust Authority STATE: OK  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Garfield County Fairgrounds Trust Authority STATE: OK Garfield County Fairgrounds Trust Authority STATE: OK PROJECT OKLAHOMA - SEP ARRA - Garfield County Fairgrounds TITLE: Funding Opportunity Announeement Number Procurement Instroment Number NEP A Control Number cm Number DE-FOA"(}000052 EEOO00133 GFO-09-332"(}13 Based on my review ofthe information eoneerning the proposed action, as NEPA CompOanee Omeer (authorized under DOE Order 451.1A), I have made the following determination: CX, EA, EIS APPENDIX AND NUMBER: Description: 85.1 Actions to conserve energy, demonstrate potential energy conservation, and promote energy-efflciency that do not increase the indoor concentrations of potentially harmful substances. These actions may involve financial and technical assistance to individuals (such as builders, owners, consultants, designers), organizations (such as utilities), and state

142

GRR/Section 3-UT-d - Geothermal Steam Lease (Utah Non-Trust Lands) | Open  

Open Energy Info (EERE)

GRR/Section 3-UT-d - Geothermal Steam Lease (Utah Non-Trust Lands) GRR/Section 3-UT-d - Geothermal Steam Lease (Utah Non-Trust Lands) < GRR Jump to: navigation, search GRR-logo.png GEOTHERMAL REGULATORY ROADMAP Roadmap Home Roadmap Help List of Sections Section 3-UT-d - Geothermal Steam Lease (Utah Non-Trust Lands) 03UTDGeothermalSteamLeaseUtahNonTrustLands.pdf Click to View Fullscreen Contact Agencies Utah Division of Forestry, Fire and State Lands Utah Department of Natural Resources Utah Division of Water Rights Utah School and Institutional Trust Lands Administration Regulations & Policies UC 65A-2-2 Mineral Leases - Division to Prescribe Rules R652-20 Mineral Resources Triggers None specified Click "Edit With Form" above to add content 03UTDGeothermalSteamLeaseUtahNonTrustLands.pdf Error creating thumbnail: Page number not in range.

143

GRR/Section 3-UT-e - Geothermal Steam Lease (Utah Trust Lands) | Open  

Open Energy Info (EERE)

3-UT-e - Geothermal Steam Lease (Utah Trust Lands) 3-UT-e - Geothermal Steam Lease (Utah Trust Lands) < GRR Jump to: navigation, search GRR-logo.png GEOTHERMAL REGULATORY ROADMAP Roadmap Home Roadmap Help List of Sections Section 3-UT-e - Geothermal Steam Lease (Utah Trust Lands) 03UTEGeothermalSteamLeaseUtahTrustLands.pdf Click to View Fullscreen Contact Agencies Utah School and Institutional Trust Lands Administration Utah Division of Water Rights Regulations & Policies UC 53C-4-102 UTLA Lease and Permit Covenants R850-27 UTLA Geothermal Steam Regulations Triggers None specified Click "Edit With Form" above to add content 03UTEGeothermalSteamLeaseUtahTrustLands.pdf Error creating thumbnail: Page number not in range. Error creating thumbnail: Page number not in range. Error creating thumbnail: Page number not in range.

144

Disability Employment Program | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Disability Employment Program Disability Employment Program Disability Employment Program The Department of Energy is committed to fostering a culture of diversity. We recognize that individuals with disabilities are an untapped talent pool and possess the skills and competencies that the Department needs to remain competitive. On July 26, 2010, President Obama issued Executive Order 13548. The Order emphasizes the Government's role as a catalyst in becoming a model employer for individuals with disabilities to include recruitment, hiring, and retention. The Order also adopts the goal set forth in Executive Order 13163 signed on July 26, 2000 by President Clinton of hiring 100,000 people with disabilities into the Federal Government over 5 years, including individuals with targeted disabilities.

145

Institute of Computer Science Trust-region interior-point method for ...  

E-Print Network (OSTI)

Institute of Computer Science. Academy of Sciences of the Czech Republic. Trust -region interior-point method for. large sparse l1 optimization. L.Lukan, C.

146

How Large are the Classification Errors in the Social Security Disability Award Process?  

E-Print Network (OSTI)

of Means Group 1 (# Obs. ) Disabled (1,596) Applicants (1,087) Non-Disabled Applicants (333) Non-Disabled Non-Applicants (25,594) Disabled

Benitez-Silva, Hugo A.; Buchinsky, Moshe; Rust, John

2004-01-01T23:59:59.000Z

147

Joshua DeLung | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DeLung About Us Joshua DeLung Joshua DeLung is an Account Manager at ENC Marketing & Communications and the Executive Editor at Relatively Journalizing. Most Recent EnerG2 Develops...

148

The Determinants of Inter-Firm trust in Supplier-Automaker Relationships In the U.S., Japan, and Korea  

E-Print Network (OSTI)

In this paper we examine the determinants of supplier trust in the buyer in 453supplier-automaker relationships in the U. S., Japan, and Korea. We define trust and derive a model of its determinants drawing upon (1) an ...

Chu, Wujin

1997-12-17T23:59:59.000Z

149

Blind chance: on potential trust friends query in mobile social networks  

Science Conference Proceedings (OSTI)

Potential-Trust-Friends-Query is an important query in mobile social network, as it enables users to discover and interact with others happen to be in their physical vicinity. In our context, we attempt to find top-k mobile users for such query. ... Keywords: check-in history, mobile social network, potential friends, trust

Jinzeng Zhang, Xiaofeng Meng

2013-06-01T23:59:59.000Z

150

A survey of trust and reputation systems for online service provision  

Science Conference Proceedings (OSTI)

Trust and reputation systems represent a significant trend in decision support for Internet mediated service provision. The basic idea is to let parties rate each other, for example after the completion of a transaction, and use the aggregated ratings ... Keywords: Collaboration, Decision, E-commerce, Reputation, Security, Transitivity, Trust

Audun Jsang; Roslan Ismail; Colin Boyd

2007-03-01T23:59:59.000Z

151

Trust, untrust, distrust and mistrust an exploration of the dark(er) side  

Science Conference Proceedings (OSTI)

There has been a lot of research and development in the field of computational trust in the past decade. Much of it has acknowledged or claimed that trust is a good thing. We think it's time to look at the other side of the coin and ask the questions ...

Stephen Marsh; Mark R. Dibben

2005-05-01T23:59:59.000Z

152

Managing data for evaluating trust in unstructured peer-to-peer networks  

Science Conference Proceedings (OSTI)

Managing data is a problem of particular importance in trust model of peer-to-peer environments where one frequently encounters unknown agents. Existing methods for data management, which are based on DHT or Random Selection, can not apply well in the ... Keywords: managing data, peer-to-peer, reputation, trust

Zhitang Li; Huaiqing Lin; Chuiwei Lu; Yejiang Zhang

2008-05-01T23:59:59.000Z

153

Chorus: scalable in-band trust establishment for multiple constrained devices over the insecure wireless channel  

Science Conference Proceedings (OSTI)

Secure initial trust establishment for multiple resource constrained devices is a fundamental issue underlying wireless networks. A number of protocols have been proposed for secure key deployment among nodes without prior shared secrets (ad hoc), however ... Keywords: key agreement, message authentication, physical-layer, security protocols, trust establishment, wireless network

Yantian Hou; Ming Li; Joshua D. Guttman

2013-04-01T23:59:59.000Z

154

STRSCNE: A Scaled Trust-Region Solver for Constrained Nonlinear Equations  

Science Conference Proceedings (OSTI)

In this paper a Matlab solver for constrained nonlinear equations is presented. The code, called STRSCNE, is based on the affine scaling trust-region method STRN, recently proposed by the authors. The approach taken in implementing the key steps of the ... Keywords: constrained equations, global convergence, performance profile, trust-region methods

Stefania Bellavia; Maria Macconi; Benedetta Morini

2004-04-01T23:59:59.000Z

155

location privacy based on trusted computing and secure logging  

E-Print Network (OSTI)

Many operators of cellphone networks now offer locationbased services to their customers, whereby an operator often outsources service provisioning to a third-party provider. Since a persons location could reveal sensitive information about the person, the operator must ensure that the service provider processes location information about the operators customers in a privacy-preserving way. So far, this assurance has been based on a legal contract between the operator and the provider. However, there has been no technical mechanism that lets the operator verify whether the provider adheres to the privacy policy outlined in the contract. We propose an architecture for location-based services based on Trusted Computing and Secure Logging that provides such a technical mechanism. Trusted Computing lets an operator query the configuration of a location-based service. The operator will hand over location information to the service only if the service is configured such that the service provider cannot get access to location information using software-based attacks. This includes passive attacks, where the provider monitors information flowing into and out of its service, and active attacks, where the provider modifies or injects customer queries to the service. We introduce several requirements that must be satisfied by a location-based service to defend against passive attacks. Furthermore, we present Secure Logging, an auditing mechanism to defend against active attacks.

Urs Hengartner

2008-01-01T23:59:59.000Z

156

Next Generation Trusted Radiation Identification System (NG-TRIS).  

SciTech Connect

The original Trusted Radiation Identification System (TRIS) was developed from 1999-2001, featuring information barrier technology to collect gamma radiation template measurements useful for arms control regime operations. The first TRIS design relied upon a multichannel analyzer (MCA) that was external to the protected volume of the system enclosure, undesirable from a system security perspective. An internal complex programmable logic device (CPLD) contained data which was not subject to software authentication. Physical authentication of the TRIS instrument case was performed by a sensitive but slow eddy-current inspection method. This paper describes progress to date for the Next Generation TRIS (NG-TRIS), which improves the TRIS design. We have incorporated the MCA internal to the trusted system volume, achieved full authentication of CPLD data, and have devised rapid methods to authenticate the system enclosure and weld seals of the NG-TRIS enclosure. For a complete discussion of the TRIS system and components upon which NG-TRIS is based, the reader is directed to the comprehensive user's manual and system reference of Seager, et al.

Flynn, Adam J.; Amai, Wendy A.; Merkle, Peter Benedict; Anderson, Lawrence Frederick; Strother, Jerry D.; Weber, Thomas M.; Etzkin, Joshua L.

2010-05-01T23:59:59.000Z

157

ANNUAL ACCOMPLISHMENT PLAN UPDATE FOR DISABLED VETERANS  

National Nuclear Security Administration (NNSA)

the FY 2012 accomplishments for Disabled Veterans for the U.S. Department of Energy (DOE) National Nuclear Security Administration (NNSA). The Office of Human Capital...

158

What You Need to Know About the Energy Security Trust | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

What You Need to Know About the Energy Security Trust What You Need to Know About the Energy Security Trust What You Need to Know About the Energy Security Trust March 15, 2013 - 12:05pm Addthis In his 2013 State of the Union address, President Obama called on Congress to create an Energy Security Trust Fund, which would free American families and business from painful spikes in gas prices. The President’s plan builds on an idea that has bipartisan support from experts including retired admirals and generals and leading CEOs, and it focuses on one goal: shifting America’s cars and trucks off oil entirely. | Infographic from the White House. In his 2013 State of the Union address, President Obama called on Congress to create an Energy Security Trust Fund, which would free American families and business from painful spikes in gas prices. The President's plan

159

Secure multi-party communication with quantum key distribution managed by trusted authority  

DOE Patents (OSTI)

Techniques and tools for implementing protocols for secure multi-party communication after quantum key distribution ("QKD") are described herein. In example implementations, a trusted authority facilitates secure communication between multiple user devices. The trusted authority distributes different quantum keys by QKD under trust relationships with different users. The trusted authority determines combination keys using the quantum keys and makes the combination keys available for distribution (e.g., for non-secret distribution over a public channel). The combination keys facilitate secure communication between two user devices even in the absence of QKD between the two user devices. With the protocols, benefits of QKD are extended to multi-party communication scenarios. In addition, the protocols can retain benefit of QKD even when a trusted authority is offline or a large group seeks to establish secure communication within the group.

Nordholt, Jane Elizabeth; Hughes, Richard John; Peterson, Charles Glen

2013-07-09T23:59:59.000Z

160

What You Need to Know About the Energy Security Trust | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

What You Need to Know About the Energy Security Trust What You Need to Know About the Energy Security Trust What You Need to Know About the Energy Security Trust March 15, 2013 - 12:05pm Addthis In his 2013 State of the Union address, President Obama called on Congress to create an Energy Security Trust Fund, which would free American families and business from painful spikes in gas prices. The President’s plan builds on an idea that has bipartisan support from experts including retired admirals and generals and leading CEOs, and it focuses on one goal: shifting America’s cars and trucks off oil entirely. | Infographic from the White House. In his 2013 State of the Union address, President Obama called on Congress to create an Energy Security Trust Fund, which would free American families and business from painful spikes in gas prices. The President's plan

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Accommodations for Vision Disabilities | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Vision Disabilities Vision Disabilities Accommodations for Vision Disabilities "Low Vision" Accommodations Glare Protection Screen - Minimizes visual fatigue associated with glare on the monitor. Large Monitor with High Resolution (19" - 25") - Increases character size in proportion to monitor dimensions and provides a crisp, sharp image. Magnified Display of Computer Screen - Either software or hardware solutions exist to present the images on the computer in a larger format. Character size can be increased up to 216 times. Magnified Display of Hardcopy Material - Hardware exists that will magnify any item placed under a CCTV camera. Documents, drawings, phone messages, etc. can be seen enlarged on a CCTV monitor. Large Print Production - Several software packages are available

162

Building Trust in GHG Inventories from the United States and China | Open  

Open Energy Info (EERE)

Building Trust in GHG Inventories from the United States and China Building Trust in GHG Inventories from the United States and China Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Counting the Gigatones: Building Trust in GHG Inventories from the United States and China Agency/Company /Organization: World Wildlife Fund Sector: Energy Focus Area: Conventional Energy Topics: GHG inventory, Background analysis Resource Type: Publications, Lessons learned/best practices Website: www.worldwildlife.org/climate/Publications/WWFBinaryitem16605.pdf Country: China, United States UN Region: Eastern Asia, Northern America Counting the Gigatones: Building Trust in GHG Inventories from the United States and China Screenshot References: GHG inventories China and US[1] "China and the United States are the world's largest emitters of

163

Weekly Address: Time to Create the Energy Security Trust | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Weekly Address: Time to Create the Energy Security Trust Weekly Address: Time to Create the Energy Security Trust Weekly Address: Time to Create the Energy Security Trust March 18, 2013 - 3:23pm Addthis Matt Compton Deputy Director of Online Content for the Office of Digital Strategy at the White House. Editor's Note: This blog is cross-posted from WhiteHouse.gov. President Obama discusses the need to harness American energy in order to reduce our dependence on oil and make the United States a magnet for new jobs. He highlights his all-of-the-above approach to American energy -- including a proposal to establish an Energy Security Trust, which invests in research that will help shift our cars and trucks off of oil. Addthis Related Articles National Energy Action Month Photo courtesy of the Pacific Northwest National Laboratory.

164

Virtual Team Trust: Instrument Development and Validation in an IS Educational Environment  

Science Conference Proceedings (OSTI)

Trust is a major factor influencing the cohesiveness among virtual team members. While recent research in the fields of information systems and management has examined this construct, there are no existing instruments that measure all the different bases ...

Saonee Sarker; Joseph S. Valacich; Suprateek Sarker

2003-04-01T23:59:59.000Z

165

What You Need to Know About the Energy Security Trust | Department...  

NLE Websites -- All DOE Office Websites (Extended Search)

In his 2013 State of the Union address, President Obama called on Congress to create an Energy Security Trust Fund, which would free American families and business from painful...

166

A dynamic trust model based on naive bayes classifier for ubiquitous environments  

Science Conference Proceedings (OSTI)

Computational models of trust have been proposed for use in ubiquitous computing environments to decide whether to provide services to requesters which are either unfamiliar with service providers or do not have enough access rights to certain services. ...

Weiwei Yuan; Donghai Guan; Sungyoung Lee; Youngkoo Lee

2006-09-01T23:59:59.000Z

167

A Reputation Model Based on Behavior Trust in Wireless Sensor Networks  

Science Conference Proceedings (OSTI)

Trust management has an important significance on the reliable operation and safety guarantee in Wireless Sensor Networks(WSNs). Previous works were implemented by exchanging key among neighboring sensors. Considering that in many cases, the sensor nodes ...

Ming-Zheng Zhou; Yi Zhang; Jun Wang; Sen-Yan Zhao

2009-09-01T23:59:59.000Z

168

Numerical study of a matrix-free trust-region SQP method for equality constrained optimization.  

SciTech Connect

This is a companion publication to the paper 'A Matrix-Free Trust-Region SQP Algorithm for Equality Constrained Optimization' [11]. In [11], we develop and analyze a trust-region sequential quadratic programming (SQP) method that supports the matrix-free (iterative, in-exact) solution of linear systems. In this report, we document the numerical behavior of the algorithm applied to a variety of equality constrained optimization problems, with constraints given by partial differential equations (PDEs).

Heinkenschloss, Matthias (Rice University, Houston, TX); Ridzal, Denis; Aguilo, Miguel Antonio

2011-12-01T23:59:59.000Z

169

Promoting trust in B2B virtual organisations through business and technological infrastructures  

Science Conference Proceedings (OSTI)

The purpose of this paper is to propose ways to increase the level of trust in online Business-to-Business (B2B) communities, through the use of business and technological schemes. From the business point of view, two mechanisms are proposed: ... Keywords: B2B, business, business-to-, e-commerce, electronic business, networking, online communities, online trading, peer architecture, peer-to-, service level agreements, support centers, trust, trustworthiness, virtual organisations, web-based communities

Ioannis Ignatiadis; Adomas Svirskas; Bob Roberts; Konstantinos Tarabanis

2006-12-01T23:59:59.000Z

170

ORNL Trusted Corridors Project: Watts Bar Dam Inland Waterway Project  

Science Conference Proceedings (OSTI)

Radiation has existed everywhere in the environment since the Earth's formation - in rocks, soil, water, and plants. The mining and processing of naturally occurring radioactive materials for use in medicine, power generation, consumer products, and industry inevitably generate emissions and waste. Radiological measuring devices have been used by industry for years to measure for radiation in undesired locations or simply identify radioactive materials. Since the terrorist attacks on the United States on 9-11-01 these radiation measuring devices have proliferated in many places in our nation's commerce system. DOE, TVA, the Army Corps and ORNL collaborated to test the usefulness of these devices in our nation's waterway system on this project. The purpose of the Watts Bar Dam ORNL Trusted Corridors project was to investigate the security, safety and enforcement needs of local, state and federal government entities for state-of-the-art sensor monitoring in regards to illegal cargo including utilization of the existing infrastructure. TVA's inland waterways lock system is a recognized and accepted infrastructure by the commercial carrier industry. Safety Monitoring activities included tow boat operators, commercial barges and vessels, recreational watercraft and their cargo, identification of unsafe vessels and carriers, and, monitoring of domestic and foreign commercial vessels and cargo identification. Safety Enforcement activities included cargo safety, tracking, identification of hazardous materials, waterway safety regulations, and hazardous materials regulations. Homeland Security and Law Enforcement Applications included Radiological Dispersive Devices (RDD) identification, identification of unsafe or illicit transport of hazardous materials including chemicals and radiological materials, and screening for shipments of illicit drugs. In the Fall of 2005 the SensorNet funding for the project expired. After several unsuccessful attempts to find a Federal sponsor to continue with the project, the Watts Bar Dam Project was canceled and the Exploranium radiation monitors were removed from the doors of Watts Bar Dam in early 2006. The DHS Domestic Nuclear Detection Office decided to proceed with a Pilot building on the ORNL work performed at the TN and SC weigh stations in the highway sector of the Trusted Corridors project and eventually expanded it to other southern states under the name of Southeastern Corridor Pilot Project (SETCP). Many of the Phase I goals were achieved however real-world test data of private watercraft and barges was never obtained.

Walker, Randy M [ORNL; Gross, Ian G [ORNL; Smith, Cyrus M [ORNL; Hill, David E [ORNL

2011-11-01T23:59:59.000Z

171

Advanced Information Techniques And Paratransit Services To Enhance Mobility Of Elderly And Disabled Travelers  

E-Print Network (OSTI)

Mobility of Elderly and Disabled Travelers: Initial SurveyKEYWORDS elderly and disabled travelers, transit,to Enhance Mobility of Disabled Travelers. Klaver, K, W.

Chen, Wan-Hui; Klaver, Kelley; Uwaine, Rochelle; Jovanis, Paul P.

1998-01-01T23:59:59.000Z

172

ITS Information And Services To Enhance The Mobility Of Disabled Travelers  

E-Print Network (OSTI)

Mobility of Elderly and Disabled Travelers: Initial Surveyto understand the needs of the disabled population, it isto Enhance the Mobility of Disabled Travelers Wan-Hui Chen,

Chen, Wan-hui; Uwaine, Rochelle; Klaver, Kelley; Kurani, Ken; Jovanis, Paul P.

1998-01-01T23:59:59.000Z

173

Formulating their future : transition to adulthood for students with profound disabilities  

E-Print Network (OSTI)

Very cognitively disabled people and the sociologicalstudents who are severely disabled. Table 1. Increase inwho are not labeled as disabled (Cooney, 2002). For other

DeZonia, Krysti Robinson

2008-01-01T23:59:59.000Z

174

Black Lung Benefits Restoration Act of 1992. Introduced in the House of Representatives, One Hundred Second Congress, Second Session, September 21, 1992  

SciTech Connect

The House report by the Committee on Education and Labor provides legislative text to make improvements in the Black Lung Benefits Act. The report is for Bill number H.R. 1637. The payments of benefits to coal miners totally disabled due to pneumoconiosis, and to the windows and dependents of those who died with such disability, or from the disease. Coal workers` pneumoconisosis is caused by the inhalation of coal mine dust. A Congressional Budget Office cost estimate of funding the bill is included.

NONE

1992-12-31T23:59:59.000Z

175

Air pollution and lung cancer  

SciTech Connect

Epidemiological evidence proves conclusively that lung cancer correlates with air pollution. However, data on lung cancer death rates and smoking show that mankind accepts the risk of long-term and low-level exposure to carcinogens. As a rule, immediate benefits are sought and remote hazards ignored. Fear of atmospheric contamination by radioactive fallout seems to be the main factor for awareness of air pollution. Experimental works help us to understand physics of particle deposition in the lungs (inertial impactation, sedimentation, Brownian movement), shed light on carcinogenesis (eg, bay region theory in case of polycyclic aromatic hydrocarbons and surface charge changes regarding asbestos), show that atmospheric particulates accepted as harmless may act as co-carcinogens (eg, iron and benzo(a)pyrene) and stress the importance of in vitro research (bacterial mutation tests, organ cultures, sister chromatid exchange system) to screen pollutants for their malignant potential and study their pathogenesis.

Boehm, G.M.

1982-01-01T23:59:59.000Z

176

Reflections on trusting trust  

E-Print Network (OSTI)

is a digitized copy derived from an ACM copyrighted work. It is not guaranteed to be an accurate copy of the author's original work.

Ken Thompson

1984-01-01T23:59:59.000Z

177

CAREERS & the disABLED Magazine's Career Expo for People with...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

CAREERS & the disABLED Magazine's Career Expo for People with Disabilities CAREERS & the disABLED Magazine's Career Expo for People with Disabilities November 22, 2013 8:00AM EST...

178

Accommodations for Physical Disabilities | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Physical Disabilities Physical Disabilities Accommodations for Physical Disabilities There are a variety of accommodation solutions available for individuals with various degrees of mobility limitation. In addition to the actual computer or telecommunications access needs, the entire office environment should be reviewed for barriers to access. Some examples would include narrow aisles that do not allow wheelchair passage, workstation surfaces that are too high or low which may result in fatigue or render the work area inaccessible, or doors that are too heavy for the individual to open. Although many individuals with mobility impairments are able to adequately determine which potential accommodation solutions would be most useful for them, others may need additional assistance. For individuals with severe

179

Accommodations for Hearing Disabilities | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Hearing Disabilities Hearing Disabilities Accommodations for Hearing Disabilities Although the general term "hearing impaired" is being used to include both deaf and hard of hearing individuals, the needs of these two groups may vary greatly. In general, people who are deaf depend more upon visual skills for communication and information in their environment while hard of hearing people enhance their usable hearing while relying on auditory input more than visual input. This general difference drives many of the concerns and needs mentioned in this section. It is key that the individual participate in the process of identifying the accommodation solution to ensure it is suitable for the individual and their needs. Visual Redundancy on Computers - Ensure that important information

180

CALIFORNIA ASSOCIATION FOR POSTSECONDARY EDUCATION AND DISABILITY (CAPED)  

E-Print Network (OSTI)

CALIFORNIA ASSOCIATION FOR POSTSECONDARY EDUCATION AND DISABILITY (CAPED) 2012 STUDENT SCHOLARSHIPS. #12;CALIFORNIA ASSOCIATION ON POSTSECONDARY EDUCATION AND DISABILITY CAPED 2012 STUDENT SCHOLARSHIP California university/college. 6. PROOF OF CURRENT ENROLLMENT Criteria: Proof of enrollment in Fall 2012

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Moore's law and the impact on trusted and radiation-hardened microelectronics.  

Science Conference Proceedings (OSTI)

In 1965 Gordon Moore wrote an article claiming that integrated circuit density would scale exponentially. His prediction has remained valid for more than four decades. Integrated circuits have changed all aspects of everyday life. They are also the 'heart and soul' of modern systems for defense, national infrastructure, and intelligence applications. The United States government needs an assured and trusted microelectronics supply for military systems. However, migration of microelectronics design and manufacturing from the United States to other countries in recent years has placed the supply of trusted microelectronics in jeopardy. Prevailing wisdom dictates that it is necessary to use microelectronics fabricated in a state-of-the-art technology for highest performance and military system superiority. Close examination of silicon microelectronics technology evolution and Moore's Law reveals that this prevailing wisdom is not necessarily true. This presents the US government the possibility of a totally new approach to acquire trusted microelectronics.

Ma, Kwok Kee

2011-12-01T23:59:59.000Z

182

Decloaking disability : images of disability and technology in science fiction media  

E-Print Network (OSTI)

This work examines how images of disability are used to frame cultural narratives regarding technology. As advances in biotechnology ensure that more people will be living with technological prosthetics against and beneath ...

Verlager, Alicia

2006-01-01T23:59:59.000Z

183

File:03UTEGeothermalSteamLeaseUtahTrustLands.pdf | Open Energy Information  

Open Energy Info (EERE)

3UTEGeothermalSteamLeaseUtahTrustLands.pdf 3UTEGeothermalSteamLeaseUtahTrustLands.pdf Jump to: navigation, search File File history File usage File:03UTEGeothermalSteamLeaseUtahTrustLands.pdf Size of this preview: 463 × 599 pixels. Other resolution: 464 × 600 pixels. Full resolution ‎(1,275 × 1,650 pixels, file size: 39 KB, MIME type: application/pdf) File history Click on a date/time to view the file as it appeared at that time. Date/Time Thumbnail Dimensions User Comment current 11:14, 30 August 2012 Thumbnail for version as of 11:14, 30 August 2012 1,275 × 1,650 (39 KB) Jnorris (Talk | contribs) You cannot overwrite this file. Edit this file using an external application (See the setup instructions for more information) File usage The following 2 pages link to this file: GRR/Flowcharts GRR/Section 3-UT-e - Geothermal Steam Lease (Utah Trust Lands)

184

File:03UTDGeothermalSteamLeaseUtahNonTrustLands.pdf | Open Energy  

Open Energy Info (EERE)

UTDGeothermalSteamLeaseUtahNonTrustLands.pdf UTDGeothermalSteamLeaseUtahNonTrustLands.pdf Jump to: navigation, search File File history File usage File:03UTDGeothermalSteamLeaseUtahNonTrustLands.pdf Size of this preview: 463 × 599 pixels. Other resolution: 464 × 600 pixels. Full resolution ‎(1,275 × 1,650 pixels, file size: 42 KB, MIME type: application/pdf) File history Click on a date/time to view the file as it appeared at that time. Date/Time Thumbnail Dimensions User Comment current 12:14, 30 August 2012 Thumbnail for version as of 12:14, 30 August 2012 1,275 × 1,650 (42 KB) Jnorris (Talk | contribs) You cannot overwrite this file. Edit this file using an external application (See the setup instructions for more information) File usage The following 2 pages link to this file: GRR/Flowcharts GRR/Section 3-UT-d - Geothermal Steam Lease (Utah Non-Trust Lands)

185

A fuzzy trust evaluation method for knowledge sharing in virtual enterprises  

Science Conference Proceedings (OSTI)

The success of virtual enterprises (VEs) depends on the effective sharing of related resources between various enterprises or workers who perform related activities. Specifically, VE success hinges on the integration and sharing of information and knowledge. ... Keywords: Fuzzy theory, Knowledge sharing, Trust, Virtual enterprise

Tsung-Yi Chen; Yuh-Min Chen; Chia-Jou Lin; Pin-Yuan Chen

2010-11-01T23:59:59.000Z

186

Antecedents of application service continuance: A synthesis of satisfaction and trust  

Science Conference Proceedings (OSTI)

Although ASP (Application Service Provider) has the potential to fundamentally change the manner in which IT services are provided for user firms, current ASPs often fail to provide good results in accumulating and retaining customers. To fill the gap ... Keywords: ASP, Application service, IS continuance, Small business, Trust

Jeoungkun Kim; Soongeun Hong; Jinyoung Min; Heeseok Lee

2011-08-01T23:59:59.000Z

187

Security and Trust Requirements Engineering Paolo Giorgini, Fabio Massacci, and Nicola Zannone  

E-Print Network (OSTI)

Security and Trust Requirements Engineering Paolo Giorgini, Fabio Massacci, and Nicola Zannone,massacci,zannone}@dit.unitn.it Abstract. Integrating security concerns throughout the whole software develop- ment process is one of today to meet. The major difficulty is that providing security does not only require to solve tech- nical

Massacci, Fabio

188

A Trust Based Distributed Kalman Filtering Approach for Mode Estimation in Power Systems  

E-Print Network (OSTI)

scale communication networks underlying the power grids make it impossible to collect data and control, the uncertainty of data accuracy has to be taken into consideration. Second, PMUs in the power grids often operateA Trust Based Distributed Kalman Filtering Approach for Mode Estimation in Power Systems Tao Jiang

Baras, John S.

189

Understanding social loafing in knowledge contribution from the perspectives of justice and trust  

Science Conference Proceedings (OSTI)

Many studies have confirmed that social loafing can greatly undermine a group's performance. The negative impact of social loafing is even more pronounced in knowledge contribution, since much valuable knowledge is implicit and thus easy to conceal. ... Keywords: Justice, Knowledge contribution, Social Exchange Theory, Social loafing, Trust

Tung-Ching Lin; Chien-Chih Huang

2009-04-01T23:59:59.000Z

190

MEDICAL INSURANCE The CHEIBA Trust is pleased to continue to offer you three medical insurance plans  

E-Print Network (OSTI)

- 23 - MEDICAL INSURANCE The CHEIBA Trust is pleased to continue to offer you three medical and are included with your medical coverage. MyAnthemTM Tired of paperwork and phone calls? MyAnthemTM takes See if your medication is on the Anthem formulary Visit MyHealth@Anthem® , powered by Web

191

How Presentation Flaws Affect Perceived Site Quality, Trust, and Intention to Purchase from an Online Store  

Science Conference Proceedings (OSTI)

Although there has been a great deal of research on impression formation, little application of that research has been made to electronic commerce. A research model was constructed that hypothesized errors, poor style, and incompleteness to be inversely ... Keywords: Intention To Purchase, Trust In E-Commerce, Web Site Credibility, Web Site Presentation Flaws, Web Site Quality

Andrea Everard; Dennis F. Galletta

2006-01-01T23:59:59.000Z

192

Supporting structured credentials and sensitive policies through interoperable strategies for automated trust negotiation  

Science Conference Proceedings (OSTI)

Business and military partners, companies and their customers, and other closely cooperating parties may have a compelling need to conduct sensitive interactions on line, such as accessing each other's local services and other local resources. Automated ... Keywords: Automated trust negotiation, access control, digital credentials, interoperable strategies

Ting Yu; Marianne Winslett; Kent E. Seamons

2003-02-01T23:59:59.000Z

193

Stabilizing trust and reputation for self-stabilizing efficient hosts in spite of Byzantine guests  

Science Conference Proceedings (OSTI)

This work presents a general and complete method to protect a system against possible malicious programs. We provide concepts for building a system that can automatically recover from an arbitrary state including even one in which a Byzantine execution ... Keywords: byzantine programs, host systems, security, self-stabilization, trust and reputation

Shlomi Dolev; Reuven Yagel

2007-11-01T23:59:59.000Z

194

Impact of consumer empowerment on online trust: An examination across genders  

Science Conference Proceedings (OSTI)

Consumer empowerment is a psychological construct related to the individual's perception of the extent to which he/she can control the distribution and use of his/her personally identifying information. It has been argued to have an impact on consumers' ... Keywords: Consumer empowerment, E-commerce, Gender differences, Privacy concerns, Trust

Vishal Midha

2012-12-01T23:59:59.000Z

195

Self-Adjustable Trust-Based Energy Efficient Routing for Smart Grid Systems  

Science Conference Proceedings (OSTI)

Smart Grid is the trend of next generation electrical power system which makes the power grid intelligent and energy efficient. It requires high level of network reliability to support two-way communication among electrical services, electrical units ... Keywords: Smart Grid, wireless mesh network, trust-based geographical routing, vulnearabilities and attacks, energy efficiency

Ming Xiang; Quan Bai; William Liu

2012-12-01T23:59:59.000Z

196

"Don't trust anyone": Privacy protection for location-based services  

Science Conference Proceedings (OSTI)

We present a decentralized approach that exploits the capability of mobile devices to form wireless personal ad-hoc networks in order to protect the privacy of users who access location-based services. The novelty of our approach is that users do not ... Keywords: Anonymity, Location-based service, Obfuscation, Privacy, Trust

Tanzima Hashem; Lars Kulik

2011-02-01T23:59:59.000Z

197

A Role-Based Trust Model for Peer-to-Peer Communities and Dynamic Coalitions  

Science Conference Proceedings (OSTI)

Although P2P systems are usually used for informationexchange between peers, they have either protectedpeers' anonymity, or required transacting peers to trusteach other implicitly. Both these approaches arevulnerable to attacks by malicious peers who ... Keywords: Communities, Dynamic Coalitions, Peer-to-Peer, Trust

Mujtaba Khambatti; Partha Dasgupta; Kyung Dong Ryu

2004-04-01T23:59:59.000Z

198

A smoothing conic trust region filter method for the nonlinear complementarity problem  

Science Conference Proceedings (OSTI)

This paper discusses nonlinear complementarity problems; its goal is to present a globally and superlinearly convergent algorithm for the discussed problems. Filter methods are extensively studied to handle nonlinear complementarity problem. Because ... Keywords: Conic model, Filter, Nonlinear complementarity problem, Trust region method

Ying Zhou

2009-07-01T23:59:59.000Z

199

A trust-semantic fusion-based recommendation approach for e-business applications  

Science Conference Proceedings (OSTI)

Collaborative Filtering (CF) is the most popular recommendation technique but still suffers from data sparsity, user and item cold-start problems, resulting in poor recommendation accuracy and reduced coverage. This study incorporates additional information ... Keywords: Cold-start, Collaborative filtering, Data sparsity, Information fusion, Recommender systems, Semantic filtering, Trust filtering

Qusai Shambour; Jie Lu

2012-12-01T23:59:59.000Z

200

Closed-loop adaptive decision support based on automated trust assessment  

Science Conference Proceedings (OSTI)

This paper argues that it is important to study issues concerning trust and reliance when developing systems that are intended to augment cognition. Operators often under-rely on the help of a support system that provides advice or that performs certain ...

Peter-Paul van Maanen; Tomas Klos; Kees van Dongen

2007-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Wireless networking security: open issues in trust, management, interoperation and measurement  

Science Conference Proceedings (OSTI)

The pervasive availability and wide usage of wireless networks with different kinds of topologies, techniques and protocol suites have brought with them a need to improve security mechanisms. The design, development and evaluation of security techniques ... Keywords: interoperation, management, measurement, network security, open security, trust, wireless networks, wireless security

Joseph B. Evans; Weichao Wang; Benjamin J. Ewy

2006-09-01T23:59:59.000Z

202

A Novel Trust-Aware Geographical Routing Scheme for Wireless Sensor Networks  

Science Conference Proceedings (OSTI)

Wireless sensor networks are vulnerable to a wide set of security attacks, including those targeting the routing protocol functionality. The applicability of legacy security solutions is disputable (if not infeasible), due to severe restrictions in node ... Keywords: Routing attacks, Secure routing, Security, Trust model, Wireless sensor networks

Theodore Zahariadis; Panagiotis Trakadas; Helen C. Leligou; Sotiris Maniatis; Panagiotis Karkazis

2013-03-01T23:59:59.000Z

203

Notices Disabled, 1401 S. Clark Street, Suite  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

13 Federal Register 13 Federal Register / Vol. 78, No. 240 / Friday, December 13, 2013 / Notices Disabled, 1401 S. Clark Street, Suite 10800, Arlington, Virginia 22202-4149. FOR FURTHER INFORMATION CONTACT: Barry S. Lineback, Telephone: (703) 603-7740, Fax: (703) 603-0655, or email CMTEFedReg@AbilityOne.gov. SUPPLEMENTARY INFORMATION: Addition On 6/28/2013 (78 FR 38952-38953), the Committee for Purchase From People Who Are Blind or Severely Disabled published notice of proposed addition to the Procurement List. After consideration of the material presented to it concerning capability of qualified nonprofit agency to provide the service and impact of the addition on the current or most recent contractors, the Committee has determined that the service listed below is suitable for procurement by the

204

Assistive Devices and Services for the Disabled: Auditory Signage and the Accessible City for Blind or Vision-Impaired Travelers  

E-Print Network (OSTI)

as many severely vision disabled people (approximately 4to improve access for disabled groups has been concentratedDevices and Services for the Disabled: Auditory Signage and

Golledge, Reginald G.; Marston, James R.; Costanzo, C. Michael

1998-01-01T23:59:59.000Z

205

Celebrating the Anniversary of the Americans with Disabilities Act |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

the Anniversary of the Americans with Disabilities Act the Anniversary of the Americans with Disabilities Act Celebrating the Anniversary of the Americans with Disabilities Act July 26, 2011 - 4:54pm Addthis Bill Valdez Bill Valdez Principal Deputy Director What does this mean for me? We are actively working to make the Energy Department a model employer for individuals with disabilities, that we're responding to the needs of our employees with disabilities, and that we're addressing Equal Employment Opportunity discrimination complaints quickly and effectively under the law. We're also working to make Energy.gov 508 compliant to deliver resources and services to you in more accessible ways. This day in history - in 1990 to be exact - the Americans with Disabilities Act (ADA) was signed into law. This civil rights legislation helps ensure

206

Job Seekers with Disabilities | National Nuclear Security Administration  

National Nuclear Security Administration (NNSA)

Seekers with Disabilities | National Nuclear Security Administration Seekers with Disabilities | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Job Seekers with Disabilities Home > Federal Employment > Our Jobs > Hiring Flexibilities > Job Seekers with Disabilities Job Seekers with Disabilities NNSA encourages persons with disabilities to apply for job openings at our

207

Business bridging ethnicity : how business transactions in Trinidad build trust and friendship but don't reduce prejudice  

E-Print Network (OSTI)

Do business transactions between individuals of different ethnicities lead to social spillovers, in terms of building trust, friendship, and reducing prejudice? In this dissertation I interrogate that research question ...

Kilroy, Austin

2011-01-01T23:59:59.000Z

208

Virtual Monotonic Counters and Count-Limited Objects using a TPM without a Trusted OS (Extended Version)  

E-Print Network (OSTI)

A trusted monotonic counter is a valuable primitive thatenables a wide variety of highly scalable offlineand decentralized applications that would otherwise be prone to replay attacks, including offline payment, e-wallets, ...

Sarmenta, Luis F. G.

2006-09-11T23:59:59.000Z

209

The effects of client disabled appearance on therapist alliance ratings.  

E-Print Network (OSTI)

?? This study was conducted in order to inform the promotion of equality of access to mental health services for persons with disabilities. Decades of (more)

MacDuffie, Heather L.

2010-01-01T23:59:59.000Z

210

Operational Plan and Desktop Reference for the Disability Employment...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Operational Plan and Desktop Reference for the Veterans Employment Program Disabled Veterans Affirmative Action Plan Office of Personnel Management (OPM) Guidance on...

211

Critical factors influencing employment of disabled persons in Malaysia.  

E-Print Network (OSTI)

??This study examines key factors that affect opportunities for employment of disabled people in Malaysia. Four factors are covered by the study; these are namely, (more)

Ramakrishnan, Prabha.

2007-01-01T23:59:59.000Z

212

Disabled women and socio-spatial 'barriers' to motherhood.  

E-Print Network (OSTI)

??Disabled womens social history of institutionalisation and spatial segregation has, over time and space, set them apart from mainstream society and rendered them invisible in (more)

McFarlane, Hazel

2004-01-01T23:59:59.000Z

213

The Effects of Client Disabled Appearance on Therapist Alliance Ratings.  

E-Print Network (OSTI)

??This study was conducted in order to inform the promotion of equality of access to mental health services for persons with disabilities. Decades of research (more)

MacDuffie, Heather L.

2010-01-01T23:59:59.000Z

214

IN REPLY REFE R TO: OFFICE OF TRUST SERVICES Memorandum To: Regional Directors  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Interior Interior IN REPLY REFE R TO: OFFICE OF TRUST SERVICES Memorandum To: Regional Directors BUREAU OF TNDIAN AFFAIRS Washington, DC 20240 SEP 2 7 2013 From: Deputy Bureau Director, Trust Services Subject: FY 2013 Climate Adaptation Grant Offering Rapidly changing climatic conditions are already impacting Tribes. The challenges from those changes span the entire range oftribal government functions and traditional use. Tribes are further challenged by limited capacity, decision support tools, and data to evaluate, prioritize and manage the change. The President' s 2013 Climate Action Plan committed to support tribes addressing climate change. In addition to support from the other federal agencies, the Bureau of Indian Affairs (BIA) has funding available for climate adaptation planning.

215

Technical Qualifications for Treating Photovoltaic Assets as Real Property by Real Estate Investment Trusts (REITs)  

DOE Green Energy (OSTI)

It has been proposed that Real Estate Investment Trusts (REITs) have the potential to lower the cost and increase the adoption of photovoltaic systems (PV) by offering a more attractive source of capital. The purpose of this paper is to explain the fundamental physical characteristics of PV and compare them to the characteristics of 'real' property, to help determine whether REITs can own PV systems.

Feldman, D.; Mendelsohn, M.; Coughlin, J.

2012-06-01T23:59:59.000Z

216

The Americans with Disabilities Act: Effective Legal Protection against Secondhand Smoke Exposure  

E-Print Network (OSTI)

ear infection may qualify as disabled under the ADA if theirLiving decision. Association for Disabled Americans, Inc. v.substantially impairs a disabled person in a place of public

Douglas, Clifford

2004-01-01T23:59:59.000Z

217

The Intersection of Feminism and Disability Theory in Sylvia Plaths The Bell Jar  

E-Print Network (OSTI)

as a woman, but as a disabled woman. For this reason,as Wendell points out, no disabled person is completelySchriempf argues that disabled women face different issues

Maple, Jeni

2009-01-01T23:59:59.000Z

218

The Mass Transit Needs Of A Non-driving Disabled Population  

E-Print Network (OSTI)

services available to disabled people The existing publicdecision support system for disabled travelers. It would beTransit Use by Non-Driving Disabled Persons: The Case of the

Golledge, Reginald G.; Costanzo, C. Michael; Marston, James R.

1996-01-01T23:59:59.000Z

219

Disability equality and discrimination in higher education: staff and student perceptions of the 'reasonable' adjustments made for print disabled students.  

E-Print Network (OSTI)

??The aim of this research was to explore staff and student experiences of the barriers print disabled students face and the adjustments made to overcome (more)

Rowlett, Emma Jane

2011-01-01T23:59:59.000Z

220

CONSTRUCTING A DISABLED IDENTITY: THE INFLUENCE OF IMPAIRMENT, SOCIAL FACTORS AND REFLECTED APPRAISALS.  

E-Print Network (OSTI)

??The claiming of an identity as disabled has important implications for impaired individuals' interpersonal interactions and well-being, however not all impaired individuals claim a disabled (more)

Ridolfo, Heather

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Testing the Behavioral Model of Health Services Use for a Disabled Population.  

E-Print Network (OSTI)

??This research examines the factors that determine physician use in a physically disabled and the mentally disabled population using Andersen's Behavioral Model of Utilization. It (more)

Greene, Angela Marie

2006-01-01T23:59:59.000Z

222

The effects of rehabilitation on intellectually disabled people: a systematic review / Sechoaro E.J.  

E-Print Network (OSTI)

??Background: Rehabilitation has emerged as a comprehensive approach with a combination of treatment modalities to address the multiple impediments associated with disabilities in intellectually disabled (more)

Sechoaro, Ernest Joshua

2011-01-01T23:59:59.000Z

223

The accessibility to basic education for disabled children in Baglung district, Nepal.  

E-Print Network (OSTI)

??Disabled people form the largest minority group in the world. In particular disabled children are vulnerable as they cannot stand up for themselves yet, in (more)

Oosterlee, A.S.

2012-01-01T23:59:59.000Z

224

Disability & Medical Leave Resources A Guide for Employees  

E-Print Network (OSTI)

Disability & Medical Leave Resources A Guide for Employees This guide is a resource for you if you are experiencing difficulties at work related to a disability or chronic medical condition. For example, you may: have a serious health condition and need medical leave be returning to work with restrictions

Saffman, Mark

225

Graduate Medical Education Committee (GMEC) Policy on Accommodations for Disabilities  

E-Print Network (OSTI)

Graduate Medical Education Committee (GMEC) Policy on Accommodations for Disabilities will be required to provide medical verification of a medical condition that he or she believes is a disability Institutional Requirements Approved by GMEC 1/12/07 II.D.4.n Office of Graduate Medical Education West Virginia

Mohaghegh, Shahab

226

A chinese cooking robot for elderly and disabled people  

Science Conference Proceedings (OSTI)

Cooking themselves is very important and difficult for elderly and disabled people in daily life. This paper presents a cooking robot for those people who are confined to wheelchairs. The robot can automatically load ingredients, cook Chinese dishes, ... Keywords: Barrier-free design, Chinese dishes, Cooking robot, Elderly and disabled people

Wen-tao Ma; Wei-xin Yan; Zhuang Fu; Yan-zheng Zhao

2011-10-01T23:59:59.000Z

227

STEM Career Showcase for Students with Disabilities - North Carolina Museum  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

STEM Career Showcase for Students with Disabilities - North STEM Career Showcase for Students with Disabilities - North Carolina Museum of Natural Sciences STEM Career Showcase for Students with Disabilities - North Carolina Museum of Natural Sciences October 16, 2013 10:00AM EDT North Carolina's Museum of Natural Sciences http://naturalsciences.org/programs-events/events/stem-career-showcase The great jobs of tomorrow will be in the fields of Science, Technology, Engineering and Math (STEM). However, people with disabilities are currently underrepresented in these fields in spite of recent advances in the accessibility of information technology and other tools used by working professionals. In honor of National Disability Employment Awareness Month in October, the Museum is hosting a STEM career showcase for students with

228

Disable Automatic Login, Cyber Security, Information Technology Division,  

NLE Websites -- All DOE Office Websites (Extended Search)

Disable Automatic Login Disable Automatic Login Automatic Login MUST be disabled... Follow the steps below to verify that auto login is disabled. Verify Security Settings Select Personal Section: Click Make sure the following required boxes are checked. - Require password to wake this computer from sleep or screen saver - Disable automatic login If so, close panel. If not, continue... Note: Mac users should have the panel locked at all times. Click the lock image to lock the panel if its open to prevent further changes. To unlock the above panel, click the lock image to bring up the login box. Insert your username & password, click . You should now be able to make changes to the panel.

229

Barriers to a Wide-Area Trusted Network Early Warning System For Electric  

E-Print Network (OSTI)

It is apparent that perturbations of the North American electric power grid follow the patterns and characteristics of Self Organized Critical (SOC) systems. Published studies show SOC systems exhibit statistical properties that may result in early warning systems predicting electric power instability and loss of reliability. However, in order for such an early warning system to exist, a trusted wide-area data network must collate information from disparate subsystems and compile that information into homogenous data records for input to a modeling system. This paper explores similarities between widearea trusted computer networks and the needs of a widearea trusted network early warning system for electric power instability. An analysis of commercial equipment used in power stations uncovers disparate access methods and protocols that inhibit interoperability, and yet that problem has been mitigated in computer networking. Recent advances lend hope that wide-area data collection and modeling of electric power system perturbations will be commonplace in the not to distant future. I. Modeling Disturbance Data The electric power grid can be modeled as a complex system of dynamic load and generation balances characterized by two types of stability. Steady-state stability describes the nominal balancing of relatively minor disturbances in load/generation fluctuations caused by normal start-up and shut-down events associated with the millions of appliances and equipment attached to the grid. Constraints on operating parameters nominally voltage levels, current magnitudes and power flows are used to achieve steady-state equilibrium where the generation input is matched to system losses and electrical outputs. Whereas, transient stability describes the power systems ability (or lack thereof) to absorb major disturbances and return to a relatively balanced steadystate. Load shedding, generation shedding, and regional

Paul W. Oman; Jeff Roberts

2002-01-01T23:59:59.000Z

230

Golden Field Office Disability Awareness Month Event | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Golden Field Office Disability Awareness Month Event Golden Field Office Disability Awareness Month Event Golden Field Office Disability Awareness Month Event October 29, 2012 10:00AM MST Golden Field Office U.S. Department of Energy 1617 Cole Blvd Golden, Co. 80401 Building 17, 4th Floor Come join us for a Disability Awareness Month program on Monday, October 29, 2012 in Bldg. 17, 4th floor, from 10:00-11:00 am. We will have a couple of performers from a Theatre group named Phamaly. Phamaly brings a unique and unusual approach to the theatre landscape. Phamaly produces professional quality live theatre with performers who are physically and/or developmentally challenged, empowering them to acquire new and improve approve upon existing skills. Phamaly also educates other theatre professionals in methods of adapting their performance to include

231

Celebrating the Anniversary of the Americans with Disabilities...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

2011 - 2:17pm Addthis Bill Valdez Bill Valdez Principal Deputy Director This day in history - in 1990 to be exact - the Americans with Disabilities Act (ADA) was signed into...

232

Faith Enterprises Inc. A Service Disabled Veteran-Owned Small...  

NLE Websites -- All DOE Office Websites (Extended Search)

Faith Enterprises Inc. A Service Disabled Veteran-Owned Small Business Security When the Air Force asked Sandia to deliver complex security upgrades to a facility on Kirtland Air...

233

KPaul A Service Disabled Veteran-Owned Small Business  

NLE Websites -- All DOE Office Websites (Extended Search)

KPaul A Service Disabled Veteran-Owned Small Business Jennifer Muth's initial phone call put her in touch with Ann Riley, Sandia's Business Point of Contact. "I work with all new...

234

THE DISABLED FAMILY DYNAMIC IN DRAMA: THE GLASS MENAGERIE, A DAY IN THE DEATH OF JOE EGG AND TIME FOR BEN.  

E-Print Network (OSTI)

??Early disability research in the social sciences focused on the individual, or the person with the disability. Only recently has disability research accepted that every (more)

Herman, Terah

2008-01-01T23:59:59.000Z

235

John Stanley, "A Miracle of Art and Nature": The Role of Disability in the Life and Career of a Blind Eighteenth-Century Musician  

E-Print Network (OSTI)

related work concerns a disabled persons relationship to4 turns to Stanley as disabled performer and performer ofstudies dealing with disabled performers opens the door to

Prescott, John Richard

2011-01-01T23:59:59.000Z

236

Toward Early Diagnosis of Lung Cancer  

Science Conference Proceedings (OSTI)

Our long term research goal is to develop a fully automated, image-based diagnostic system for early diagnosis of pulmonary nodules that may lead to lung cancer. In this paper, we focus on generating new probabilistic models for the estimated growth ...

Ayman El-Baz; Georgy Gimel'Farb; Robert Falk; Mohamed Abou El-Ghar; Sabrina Rainey; David Heredia; Teresa Shaffer

2009-10-01T23:59:59.000Z

237

National Heart, Lung, and Blood Institute  

E-Print Network (OSTI)

National Heart, Lung, and Blood Institute A T - A - G L A N C E : What You Need To Know About High- tors for heart disease. In fact, the higher your blood cholesterol, the greater your risk of developing heart disease or having a heart attack. Heart disease is the #1 killer of men and women in the United

Bandettini, Peter A.

238

National Heart, Lung, and Blood Institute  

E-Print Network (OSTI)

National Heart, Lung, and Blood Institute A T - A - G L A N C E : Coronary Heart Disease C oronary heart disease (CHD), also called coronary artery disease, is the leading cause of death in the United. These arteries supply your heart muscle with oxygen-rich blood. Plaque is made up of fat, cholesterol, calcium

Bandettini, Peter A.

239

National Heart, Lung, and Blood Institute  

E-Print Network (OSTI)

National Heart, Lung, and Blood Institute A T - A - G L A N C E : Physical Activity and Your Heart, is that even modest amounts of physi- cal activity are good for your health, especially your heart health activity is the type of physical activity that benefits your heart the most. This type of activity moves

Bandettini, Peter A.

240

Trusting expert- versus user-generated ratings online: The role of information volume, valence, and consumer characteristics  

Science Conference Proceedings (OSTI)

The warranting principle, signaling theory, and theories of informational social influence suggest conditions when either user-generated information, or information originating from traditional experts, might be privileged online. A random sample of ... Keywords: Credibility, Online ratings, Online social influence, Social media, Trust, User-generated content

Andrew J. Flanagin, Miriam J. Metzger

2013-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Experiential knowledge in the development of decisional DNA (DDNA) and decisional trust for global e-decisional community  

Science Conference Proceedings (OSTI)

In the nineties, Peter Drucker envisaged that "the traditional factors of production - land, labour and capital are becoming restraints rather than driving forces" and "Knowledge is becoming the one critical factor of production". Welcoming the onset ... Keywords: decisional DNA, experience, knowledge representation, trust

Edward Szczerbicki; Cesar Sanin

2011-09-01T23:59:59.000Z

242

Cyberspace Policy Review: Assuring a Trusted and Resilient Information and Communications Infrastructure  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

y b y b e R s pA C e p o l I C y R e v I e w Assuring a Trusted and Resilient Information and Communications Infrastructure Preface Cyberspace touches practically everything and everyone. It provides a platform for innovation and prosperity and the means to improve general welfare around the globe. But with the broad reach of a loose and lightly regulated digital infrastructure, great risks threaten nations, private enterprises, and individual rights. The government has a responsibility to address these strategic vulnerabilities to ensure that the United States and its citizens, together with the larger community of nations, can realize the full potential of the information technology revolution. The architecture of the Nation's digital infrastructure, based largely upon the Internet, is not secure or

243

Public Transit Use By Non-driving Disabled Persons: The Case Of The Blind And Vision Impaired  

E-Print Network (OSTI)

Transit Use by Non-Driving Disabled Persons: the Case of theTransit Use by Non-Driving Disabled Persons: The Case of theand movement potential of the disabled non-driving group. We

Golledge, R.; Costanzo, C. M.; Marston, J.

1996-01-01T23:59:59.000Z

244

Characteristics, Welfare Use and Material Hardship Among California AFDC Households with Disabled and Chronically Ill Family Members  

E-Print Network (OSTI)

Families with Severely Disabled Members, 262 cases weightedA F D C Households with Disabled and Chronically 111 Familylevels. 1'he treatment o f disabled individuals in these

Meyers, Marcia k.

1996-01-01T23:59:59.000Z

245

Special Educators' Perspectives of Aligning Individual Education Program Goals of Students with Severe Disabilities with the General Education Curriculum.  

E-Print Network (OSTI)

??Aligning Individual Education Program (IEP) goals of students with severe disabilities with the general education curriculum is required by the Individuals with Disabilities Education Improvement (more)

Tonga, Kristi Noel

2011-01-01T23:59:59.000Z

246

Rebate Program Serves Alaskans with Disabilities | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Serves Alaskans with Disabilities Serves Alaskans with Disabilities Rebate Program Serves Alaskans with Disabilities July 21, 2010 - 2:10pm Addthis Lorelei Laird Writer, Energy Empowers What are the key facts? Energy efficient appliances are made more affordable in rural Alaska thanks to $500 rebates. With rates of up to .50 kWh in Alaska, energy efficient appliances reduce energy bills. Alaska applies Recovery Act funding to lower administrative costs of their rebate program. According to the U.S. Census Population Finder, the estimated population of Alaska as of 2009 was 698,473. In the same year, Alaska was awarded $658,000 as part of the State Appliance Rebate Program, an American Recovery and Reinvestment Act program that helps Americans purchase ENERGY STAR appliances to replace older, inefficient models. That grant worked out

247

FY14 Affirmative Action Program Plan for Disabled Veterans  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FY14 Affirmative Action Program Plan for FY14 Affirmative Action Program Plan for Disabled Veterans 1. PURPOSE: This Affirmative Action Program Plan for Disabled Veterans (Plan) establishes policy and procedures, identifies responsibilities, and in connection with the Department of Energy Operational Plan and Desktop Reference for the Veterans Employment Initiative sets objectives for the Department of Energy (DOE). It has become an attachment to the Operational Plan. 2. SCOPE: The Plan is to serve as the guide for the Disabled Veterans' Affirmative Action Program (DVAAP) for all elements of the Department of Energy (DOE). 3. REFERENCES: A. Equal Employment Opportunity Commission (EEOC) Management Directive (MD) 715 and Guidance: http://www.eeoc.gov/federal/directives/md715instruct.cfm.

248

A research study investigating methods of obtaining the views and opinions of disabled children about spirituality.  

E-Print Network (OSTI)

??Aims: To identify and evaluate effective interview methods for accessing disabled childrens views on spirituality. To explore disabled childrens theories of spirituality with regards to (more)

Loader, Beth

2010-01-01T23:59:59.000Z

249

Partial Disability System and Labor Market Adjustment: The Case of Spain  

E-Print Network (OSTI)

Although partially disabled individuals in Spain are allowed to combine the receipt of disability benefits with a job, the empirical evidence shows that employment rates for this group of individuals are very low. Therefore, in this paper we construct labor market model with search intensity and matching frictions in order to identify the incentives and disincentives to work provided by the partial disability system in Spain from the point of view of both disabled individuals and employers. According to the model, the high employment rate gap observed between nondisabled and disabled workers can be partially explained by the presence of a lower level of productivity and higher searching costs among disabled individuals that discourage them from looking for jobs. Moreover, the design of the Spanish Disability System also contributes in explaining this gap. We also analyze the role of business cycle conditions in shaping the labor market transitions of disabled individuals.

Jose I. Silva; Judit Vall-castello; Jose I. Silva; Judit Vall-castello

2013-01-01T23:59:59.000Z

250

Stuck at the Bottom Rung: Occupational Characteristics of Workers with Disabilities  

E-Print Network (OSTI)

to 19.7% (among dishwashers). For sensory disability,scientists) to 4.9% (dishwashers, again). Representation of

Kaye, H. Stephen

2009-01-01T23:59:59.000Z

251

OPM Model Strategies for Recuitment and Hiring of People With Disabilities  

Energy.gov (U.S. Department of Energy (DOE))

OPM Guidance on creating and implementing a strategic approach to hiring individuals with disabilities for each Federal Agency.

252

An American Perspective on British Higher Education: The Decline of Diversity, Autonomy and Trust in Post-war British Higher Education  

E-Print Network (OSTI)

Perspective on British Higher Education: The Decline ofTrust in Post-war British Higher Education 1 Martin Trow TheCenter for Studies in Higher Education UC Berkeley, CA 94720

Trow, Martin A

2005-01-01T23:59:59.000Z

253

Method and apparatus for measuring lung density by Compton backscattering  

DOE Patents (OSTI)

The density of the lung of a patient suffering from pulmonary edema is monitored by irradiating the lung by a single collimated beam of monochromatic photons and measuring the energies of photons compton back-scattered from the lung by a single high-resolution, high-purity germanium detector. A compact system geometry and a unique data extraction scheme are utilized to minimize systematic errors due to the presence of the chestwall and multiple scattering. 11 figs., 1 tab.

Loo, B.W.; Goulding, F.S.

1988-03-11T23:59:59.000Z

254

Former Worker Program - Early Lung Cancer Detection Program  

NLE Websites -- All DOE Office Websites (Extended Search)

Former Worker Program (FWP) Former Worker Program (FWP) Home Covered Sites/Populations › Construction Worker Screening Projects › Production Worker Screening Projects › Supplemental Screening Program › Beryllium Vendor Screening Program Upcoming Events Program Implementation Outreach Medical Screening - Conventional Medical Screening - Early Lung Cancer Detection Communicating Results Protecting Participant Information Sharing De-identified Data Chronic Beryllium Disease Awareness Joint Outreach Task Group (JOTG) Worker Testimonials Contact Us FWP Scientific Publications FWP Documents Related Links Office of Health and Safety Home Page HSS Logo Early Lung Cancer Detection Program Former Worker Medical Screening Program (FWP) Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer. Through the FWP, DOE initiated the Early Lung Cancer Detection (ELCD) program using low-dose helical CT scans to detect lung cancers at an earlier, more treatable stage. Lung cancer results in about 160,000 deaths in the U.S. every year. The most common causes of lung cancer are long-term exposures to tobacco smoke and residential radon emissions, but occupational hazards, such as asbestos and ionizing radiation, also cause or contribute to the disease.

255

the Front Line of Medicine to Prevent Needless Work Disability  

E-Print Network (OSTI)

Preparing the Front Line of Medicine to Prevent Needless Work Disability: Private 4. Free on-line CME; "Medical Rounds" in a talk show format 3. Free live;6 Approaches 1. Sessions at exis9ng medical educa9on events 2. Offer of on-line CME training

256

The Employment Process: Effects on the Learning Disabled  

Science Conference Proceedings (OSTI)

Sep 9, 2008 ... Since about 1982 (3rd year of my B.Sc.), I have been interacting with the ... employment process, Internet edition, on 3 occasions. ... I really don't like bringing conflict into inter-personal (social) ... disabled" think of STUPID!

257

Evaluation of wordtree system with motor disabled users  

Science Conference Proceedings (OSTI)

In this paper we propose a novel interaction technique to use with a prediction list. Our aim is to optimize the use of this assistive aid. A prediction list is generally used to reduce effort by presenting a list of candidate words that may continue ... Keywords: interaction, motor disabled people, soft keyboard, word list prediction

Georges Badr; Mathieu Raynal

2010-07-01T23:59:59.000Z

258

A qualitative study of the relationship between disability, access and service provisions on the quality of life of the disabled in the Greater Durban Metropolitan Area.  

E-Print Network (OSTI)

??Disabled people live in a complex world encompassing the same interests and desires that motivate the balance of the earth's population. We have always known (more)

Konar, Devoshini.

2008-01-01T23:59:59.000Z

259

Master Limited Partnerships and Real Estate Investment Trusts: Opportunities and Potential Complications for Renewable Energy  

SciTech Connect

Master Limited Partnerships (MLPs) and Real Estate Investment Trusts (REITs) are two proposed investment vehicles which have the potential to lower renewable energy assets' high cost of capital; a critical factor in the Department of Energy's goal for renewable energy to achieve grid-parity with traditional sources of electric generation. Due to current U.S. federal income tax laws, regulations, and administrative interpretations, REITs and MLPs cannot finance a significant portion of the cost of renewable energy assets. Efforts are underway to alter these rules by changing the definition of 'real property' (REIT) and 'qualified income' (MLP). However, even with rule changes, both investment vehicles have structural challenges to efficiently finance renewable energy assets. Among them are 1) effectively utilizing the U.S. federal income tax incentives; 2) administratively structuring the investments to not be overly onerous or complicated, given the potential for pooling a relatively large amount of small assets; and 3) attracting and retaining a large enough investment community to participate in the funding opportunities. This report summarizes these challenges so that if proposed federal changes are made, stakeholders have an understanding of the possible outcomes.

Feldman, D.; Settle, E.

2013-11-01T23:59:59.000Z

260

Panel report: radiotherapy for lung cancer  

SciTech Connect

Research programs designed to establish the most effective treatment schedule for lung neoplasms are reviewed, with emphasis on radiotherapy. It was concluded that the design of protocols should be to provide total therapy to all compartments of disease: local tumor, regional nodes, and distant metastases. Rather than a competitive approach as utilized in the past, each modality should be utilized as a reductive procedure of the tumor burden. As each treatment is combined effectively and efficiently in a logical sequence before the overt appearance of metastases occurs, increased tumor control and survival may eventuate. (auth)

Rubin, P.

1973-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Biobased Surfactants and DetergentsChapter 8 Lung Surfactants Formulation Evaluation  

Science Conference Proceedings (OSTI)

Biobased Surfactants and Detergents Chapter 8 Lung Surfactants Formulation Evaluation Surfactants and Detergents eChapters Surfactants - Detergents Press Downloadable pdf of Chapter 8 Lung Surfactan

262

The role of ?-catenin in activated EGFR-driven lung tumourigenesis.  

E-Print Network (OSTI)

??Lung cancer is associated with a high mortality rate, with Non-Small Cell Lung Cancer (NSCLC) accounting for the majority of cases. Mutations in the epidermal (more)

Sng, Joo Li Natasha

2011-01-01T23:59:59.000Z

263

Atrial natriuretic polypeptide-like material in rat lung  

SciTech Connect

Atrial natriuretic polypeptide-like immunoreactive material (ANP-IR) was found in rat lung by radioimmunoassay, with the concentration ranging from 0.6-1.2 pmol/g of tissue in each lobe. PAP-immunohistochemical study demonstrated that specific staining of granules for ..cap alpha..-human ANP are mainly located in the muscular layer of the pulmonary vein. Fractionation of lung extract by gel filtration and reserve phase HPLC revealed the presence of multiple forms of ANP-IR, which possibly possessed molecular structure partially different from rat ANP, atriopeptin I and III. Intravenous injection of lung extract induced potent diuresis and natriuresis in rats. These responses could be abolished when the lung extract was preincubated with antiserum for ..cap alpha..-human ANP. Specific binding sites for /sup 125/I-labeled rat ANP were also found in lung membrane preparation by radioreceptor assay. Incubation of synthetic atriopeptin III (10/sup -9/ to 10/sup -6/M) with lung tissue induced 1-28 fold increase in lung cGMP content. The results suggest that ANP-IR and its receptors existing in rat lung may be involved in the regulation of pulmonary function and have a synergic effect with ANP of cardiac origin in the control of water-electrolytes balance.

Chang, J.K.; Chang, D.; Xie, C.W.; Song, D.L.; Li, X.R.; Zhang, S.X.; Wang, T.L.; Tang, J.

1986-03-05T23:59:59.000Z

264

Examination Report on "The Department of Energy's American Recovery and Reinvestment Act of 2009 Energy Efficiency and Conservation Block Grant Program - Efficiency Maine Trust", OAS-RA-13-04  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

The Department of Energy's The Department of Energy's American Recovery and Reinvestment Act Energy Efficiency and Conservation Block Grant Program - Efficiency Maine Trust OAS-RA-13-04 November 2012 Department of Energy Washington, DC 20585 November 8, 2012 MEMORANDUM FOR THE ASSISTANT SECRETARY FOR ENERGY EFFICIENCY AND RENEWABLE ENERGY FROM: Rickey R. Hass Deputy Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Examination Report on "The Department of Energy's American Recovery and Reinvestment Act of 2009 Energy Efficiency and Conservation Block Grant Program - Efficiency Maine Trust" INTRODUCTION AND OBJECTIVE The attached report presents the results of an examination of the Efficiency Maine Trust's (Trust)

265

Physiological Interaction of Heart and Lung in Thoracic Irradiation  

SciTech Connect

Introduction: The risk of early radiation-induced lung toxicity (RILT) limits the dose and efficacy of radiation therapy of thoracic tumors. In addition to lung dose, coirradiation of the heart is a known risk factor in the development RILT. The aim of this study was to identify the underlying physiology of the interaction between lung and heart in thoracic irradiation. Methods and Materials: Rat hearts, lungs, or both were irradiated to 20 Gy using high-precision proton beams. Cardiopulmonary performance was assessed using breathing rate measurements and F{sup 18}-fluorodeoxyglucose positron emission tomography ({sup 18}F-FDG-PET) scans biweekly and left- and right-sided cardiac hemodynamic measurements and histopathology analysis at 8 weeks postirradiation. Results: Two to 12 weeks after heart irradiation, a pronounced defect in the uptake of {sup 18}F-FDG in the left ventricle (LV) was observed. At 8 weeks postirradiation, this coincided with LV perivascular fibrosis, an increase in LV end-diastolic pressure, and pulmonary edema in the shielded lungs. Lung irradiation alone not only increased pulmonary artery pressure and perivascular edema but also induced an increased LV relaxation time. Combined irradiation of lung and heart induced pronounced increases in LV end-diastolic pressure and relaxation time, in addition to an increase in right ventricle end-diastolic pressure, indicative of biventricular diastolic dysfunction. Moreover, enhanced pulmonary edema, inflammation and fibrosis were also observed. Conclusions: Both lung and heart irradiation cause cardiac and pulmonary toxicity via different mechanisms. Thus, when combined, the loss of cardiopulmonary performance is intensified further, explaining the deleterious effects of heart and lung coirradiation. Our findings show for the first time the physiological mechanism underlying the development of a multiorgan complication, RILT. Reduction of dose to either of these organs offers new opportunities to improve radiation therapy treatment of thoracic tumors, potentially facilitating increased treatment doses and tumor control.

Ghobadi, Ghazaleh; Veen, Sonja van der [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands) [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Bartelds, Beatrijs [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Boer, Rudolf A. de [Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Dickinson, Michael G. [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Jong, Johan R. de [Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Faber, Hette; Niemantsverdriet, Maarten [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands) [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Brandenburg, Sytze [Kernfysisch Versneller Instituut, University of Groningen, Groningen (Netherlands)] [Kernfysisch Versneller Instituut, University of Groningen, Groningen (Netherlands); Berger, Rolf M.F. [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Langendijk, Johannes A. [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Coppes, Robert P. [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands) [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Luijk, Peter van, E-mail: p.van.luijk@umcg.nl [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)

2012-12-01T23:59:59.000Z

266

Review Genomic approaches to research in lung cancer  

E-Print Network (OSTI)

The medical research community is experiencing a marked increase in the amount of information available on genomic sequences and genes expressed by humans and other organisms. This information offers great opportunities for improving our understanding of complex diseases such as lung cancer. In particular, we should expect to witness a rapid increase in the rate of discovery of genes involved in lung cancer pathogenesis and we should be able to develop reliable molecular criteria for classifying lung cancers and predicting biological properties of individual tumors. Achieving these goals will require collaboration by scientists with specialized expertise in medicine, molecular biology, and decision-based statistical analysis.

Edward Gabrielson

2000-01-01T23:59:59.000Z

267

Combining Neural Network and Genetic Algorithm for Prediction of Lung Sounds  

Science Conference Proceedings (OSTI)

Recognition of lung sounds is an important goal in pulmonary medicine. In this work, we present a study for neural networks--genetic algorithm approach intended to aid in lung sound classification. Lung sound was captured from the chest wall of The subjects ... Keywords: MLP, auscultation, genetic algorithm, lung sounds, neural network, respiratory diseases

?nan Gler; Hseyin Polat; Uman Ergn

2005-06-01T23:59:59.000Z

268

Disabling equational theories in unification for cryptographic protocol analysis through tagging  

E-Print Network (OSTI)

In this paper, we show a new tagging scheme for cryptographic protocol messages. Under this tagging, equational theories of operators such as exclusive-or, binary addition etc. are effectively disabled, when terms are unified. We believe that this result has a significant impact on protocol analysis and security, since unification is at the heart of symbolic protocol analysis. Hence, disabling equational theories in unification implies disabling them altogether in protocol analysis for most operators and theories.

Malladi, Sreekanth

2010-01-01T23:59:59.000Z

269

Experiences of Adults with Developmental Disability and a Teacher of Mathematics in the Money Club.  

E-Print Network (OSTI)

??In my experiences, students with Developmental Disability (DD) are routinely excluded from Algebra and other high-level mathematics courses. People with DD do not have the (more)

Rodriguez, Anthony Matthew

2012-01-01T23:59:59.000Z

270

A handbook for Disability Resource Center counselors at Sacramento City College.  

E-Print Network (OSTI)

??The purpose of this project was to develop a revised handbook for the Disability Resource Center counselors at Sacramento City College. There is an immediate (more)

Piskun, Yelena

2013-01-01T23:59:59.000Z

271

An algebra handbook: instructional strategies for assisting college students with learning disabilities.  

E-Print Network (OSTI)

??An Algebra handbook of instructional strategies was created for the Learning Disabilities department staff at American River College in Northern California. The handbook is designed (more)

Harris, Maya S.

2010-01-01T23:59:59.000Z

272

Sacrificial limbs of sovereignty : disabled veterans, masculinity, and nationalist politics in Turkey.  

E-Print Network (OSTI)

??This dissertation concerns the disabled veterans of the Turkish army who fought against the Kurdistan Workers Party (PKK) guerillas as conscripted soldiers. While being valorized (more)

Aciksoz, Salih Can

2012-01-01T23:59:59.000Z

273

Barriers facing disables in getting jobs in Ghana : quality of life situation.  

E-Print Network (OSTI)

??Abstract Discrimination against persons with disabilities the world over in the realm of employment has been a real problem especially in developing countries such as (more)

Ntibea, Juliana

2011-01-01T23:59:59.000Z

274

The integration of disabled people in the daily working life in the German primary labor market.  

E-Print Network (OSTI)

??The aim of this study was to examine and bring to light any issues currently confronting the disabled community when looking to integrate themselves into (more)

Milcher, Magdalena

2013-01-01T23:59:59.000Z

275

Is classroom management possible for disabled teachers, with or without accommodation?.  

E-Print Network (OSTI)

??The central question of the thesis Is classroom management possible for disabled teachers with or without accommodation? is addressed through a review of the literature, (more)

Hazen, Martha A

2012-01-01T23:59:59.000Z

276

What can disabled academics' career experiences offer to studies of organization?.  

E-Print Network (OSTI)

??Whilst there have been calls to theorize and explore how disability and ableism are constructed through organizing processes as a contribution to the critique of (more)

Williams, Jannine

2011-01-01T23:59:59.000Z

277

Developing and managing a vocational training and transition planning programme for intellectually disabled learners.  

E-Print Network (OSTI)

??Little information is available on future vocational preparation for intellectually disabled learners in South African schools. Currently teachers adapt the Revised National Curriculum Statement (RNCS) (more)

Vlachos, Catharina Johanna

2008-01-01T23:59:59.000Z

278

Assistive technology for students with learning disabilities in writing: beliefs, knowledge, and use.  

E-Print Network (OSTI)

??The purpose of this study was to investigate special education teacher beliefs, knowledge and use of assistive technology for students with learning disabilities in writing. (more)

Bigelow, Diane Lynette

2008-01-01T23:59:59.000Z

279

Lung cancer epidemiology in New Mexico uranium miners  

SciTech Connect

This investigation assesses the health effects of radon progeny exposure in New Mexico uranium miners. Cumulative exposures sustained by most New Mexico miners are well below those received earlier in the Colorado Plateau. This project utilizes the research opportunity offered by New Mexico miners to address unresolved issues related to radon progeny exposure: (1) the lung cancer risk of lower levels of exposure, (2) interaction between radon progeny exposure and cigarette smoking in the causation of lung cancer, (3) the relationship between lung cancer histologic type and radon progeny exposure, and (4) possible effects of radon progeny exposure other than lung cancer. A cohort study of 3800 men with at least one year of underground uranium mining experience in New Mexico is in progress. Results are discussed.

Samet, J.M.

1991-11-01T23:59:59.000Z

280

Thionyl-chloride-induced lung injury and bronchiolitis obliterans  

SciTech Connect

Thionyl-chloride (TCl) is used in the manufacture of lithium batteries, producing SO2 and HCl fumes on contact with water. We report two cases of accidental TCl exposure resulting in lung injury that may vary from a relatively mild and reversible interstitial lung disease to a severe form of bronchiolitis obliterans causing, after a latent period, an acute/chronic respiratory failure as well as other complications (spontaneous pneumothorax and bronchopleural fistula), previously unreported in TCl fume inhalation.

Konichezky, S.; Schattner, A.; Ezri, T.; Bokenboim, P.; Geva, D. (Kaplan Hospital, Rehovot (Israel))

1993-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

The design, development, and dissemination of a small-business wheelchair to empower people with disabilities in Developing countries  

E-Print Network (OSTI)

This thesis discusses the design of a small-business wheelchair that empowers disabled people in developing countries to become entrepreneurs. Disabled people in these countries face tremendous discrimination, making it ...

Scolnik, Natasha (Natasha Kathryn)

2010-01-01T23:59:59.000Z

282

Does the Use of Co-teaching Models in Algebra Result in an Increase in Student Achievement Among Students with Disabilities and Their Non-disabled Peers?.  

E-Print Network (OSTI)

?? This study investigated high school students with special needs and their non-disabled peers in a Maryland public school system who were taught by co-teachers (more)

Whisted, Melissa Lembo

2011-01-01T23:59:59.000Z

283

The University of Texas at Austin Services for Students with Disabilities Alternative Format Services Registration Agreement  

E-Print Network (OSTI)

The University of Texas at Austin Services for Students with Disabilities Alternative Format be registered as a student at The University of Texas at Austin. 2. You must be enrolled in the Services University of Texas at Austin Services for Students with Disabilities Alternative Format Services

Texas at Austin, University of

284

Building public trust: Actions to respond to the report of the Advisory Committee on human radiation experiments  

Science Conference Proceedings (OSTI)

Democratic government requires trust: people need to know and believe that the government is telling the truth. Without information about what the government is doing and why, citizens cannot exercise democratic control over government institutions. During his first year in office, President Clinton became concerned about reports that the government had conducted unethical secret human radiation experiments during the Cold War. To address this issue, in January 1994, President Clinton established the Advisory Committee on Human Radiation Experiments (ACHRE), chaired by bioethicist Dr. Ruth Faden of Johns Hopkins University. The President also directed all Federal agencies to search for records related to human subjects radiation research and provide them to the Advisory Committee. This report presents the Administration`s actions to respond to the ACHRE`s findings and recommendations.

NONE

1997-03-01T23:59:59.000Z

285

Partnership with parents and disabled children. HIA of the All-Inclusive Wraparound Project for children with a disability  

SciTech Connect

The All-Inclusive Wraparound Scheme seeks to develop new ways of multidisciplinary, interagency working that will make a difference to the lives of children with disabilities (aged 0-18 years) and their families and carers across the Southern Health and Social Services Board in Northern Ireland. A concurrent HIA was undertaken with the aims of identifying the positive and negative health impacts, producing clear recommendations to improve the service and informing the development of an evaluation and monitoring framework. Eight community-based projects linked to 15 partners were involved in the HIA. Health and social services, education, the Library Board, voluntary sector community groups, parents and children all took part. It was concluded that there was a need for better information for parents to enable them to access services. Partnership working with parents and between agencies needed to be improved and parents and professionals on partnership working. The handover between services at transition from preschool to school-age and from school-age to adult services needed to be better planned. Conducting a HIA early in the implementation of Wraparound has enabled the project to take account of more perspectives and influence the delivery of services for children with a disability.

Farrell, Brid; Elliott, Iris; Ison, Erica

2004-02-01T23:59:59.000Z

286

Low Dose Radiation Research Program: Biologically Based Analysis of Lung  

NLE Websites -- All DOE Office Websites (Extended Search)

Biologically Based Analysis of Lung Cancer Incidence in a Large Biologically Based Analysis of Lung Cancer Incidence in a Large Canadian Occupational Cohort with Low-LET Low-dose Radiation Exposure, and Comparison with Japanese Atomic Bomb Survivors. Authors: W.D. Hazelton, D. Krewski, S.H. Moolgavkar Lung cancer incidence is analyzed in a large Canadian National Dose Registry (CNDR) cohort with individual annual dosimetry for low-dose occupational exposure to gamma and tritium radiation using several types of multistage models. The primary analysis utilizes the two-stage clonal expansion model (TSCE), with sensitivity analyses using extensions of this model incorporating additional stages. Characteristic and distinct temporal patterns of risk are found for dose-response affecting early, middle, or late stages of carcinogenesis, e.g., initiation with one or more stages,

287

Endotoxin suppresses surfactant synthesis in cultured rat lung cells  

Science Conference Proceedings (OSTI)

Pulmonary complications secondary to postburn sepsis are a major cause of death in burned patients. Using an in vitro organotypic culture system, we examined the effect of E. coli endotoxin (LPS) on lung cell surfactant synthesis. Our results showed that E. coli endotoxin (1.0, 2.5, 10 micrograms LPS/ml) was capable of suppressing the incorporation of /sup 3/H-choline into de novo synthesized surfactant, lamellar bodies (LB), and common myelin figures (CMF) at 50%, 68%, and 64%, respectively. In a similar study, we were able to show that LPS also inhibited /sup 3/H-palmitate incorporation by cultured lung cells. LPS-induced suppression of surfactant synthesis was reversed by hydrocortisone. Our results suggest that LPS may play a significant role in reducing surfactant synthesis by rat lung cells, and thus contribute to the pathogenesis of sepsis-related respiratory distress syndrome (RDS) in burn injury.

Li, J.J.; Sanders, R.L.; McAdam, K.P.; Gelfand, J.A.; Burke, J.F.

1989-02-01T23:59:59.000Z

288

Residential radon and lung cancer incidence in a Danish cohort  

SciTech Connect

High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993-1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed. Median estimated radon was 35.8 Bq/m{sup 3}. The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69-1.56) in association with a 100 Bq/m{sup 3} higher radon concentration and 1.67 (95% CI: 0.69-4.04) among non-smokers. We found no evidence of effect modification. We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

Braeuner, Elvira V., E-mail: ole@cancer.dk [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Danish Building Research Institute, Aalborg University (Denmark); Andersen, Claus E. [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark)] [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark); Sorensen, Mette [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Jovanovic Andersen, Zorana [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark) [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Center for Epidemiology Screening, Department of Public Health, University of Copenhagen (Denmark); Gravesen, Peter [Geological Survey of Denmark and Greenland, Copenhagen (Denmark)] [Geological Survey of Denmark and Greenland, Copenhagen (Denmark); Ulbak, Kaare [National Institute of Radiation Protection, Herlev (Denmark)] [National Institute of Radiation Protection, Herlev (Denmark); Hertel, Ole [Department of Environmental Science, Aarhus University, Aarhus (Denmark)] [Department of Environmental Science, Aarhus University, Aarhus (Denmark); Pedersen, Camilla [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Overvad, Kim [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark)] [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark); Tjonneland, Anne; Raaschou-Nielsen, Ole [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)

2012-10-15T23:59:59.000Z

289

Differential Molecular Changes in the Lung after Low and High Carcinogen  

NLE Websites -- All DOE Office Websites (Extended Search)

Differential Molecular Changes in the Lung after Low and High Carcinogen Differential Molecular Changes in the Lung after Low and High Carcinogen Doses and Implications for Designing Molecular Epidemiology and other Studies of Radiation-Induced Lung Cancer Bobby R. Scott Lovelace Respiratory Research Institute Abstract Lung Cancer Mortality Worldwide by Gender: Lung cancer was the most commonly diagnosed cancer worldwide as well as the leading cause of cancer death in males in 2008 (Jemal et al. 2011). For females, it was the fourth most commonly diagnosed cancer and the second leading cause of cancer death. Lung cancer accounted for 13% of the total cases and 18% of the cancer deaths. For males, the highest lung cancer incidence rates are in Central and Eastern Europe, Southern Europe, and Northern America. For females, the highest lung cancer incidence rates are in Northern America,

290

The ultrastructure of book lung development in the bark scorpion Centruroides gracilis (Scorpiones: Buthidae)  

E-Print Network (OSTI)

hemo- lymph channels of adult book lungs in scorpions and16 References 1. Farley RD: Book gill development in embryosrelationship of the lung-book of Scorpio to the gill-book of

Farley, Roger D

2011-01-01T23:59:59.000Z

291

Arsenic in drinking water and lung cancer: A systematic review  

SciTech Connect

Exposure to inorganic arsenic via drinking water is a growing public health concern. We conducted a systematic review of the literature examining the association between arsenic in drinking water and the risk of lung cancer in humans. Towards this aim, we searched electronic databases for articles published through April 2006. Nine ecological studies, two case-control studies, and six cohort studies were identified. The majority of the studies were conducted in areas of high arsenic exposure (100 {mu}g/L) such as southwestern Taiwan, the Niigata Prefecture, Japan, and Northern Chile. Most of the studies reported markedly higher risks of lung cancer mortality or incidence in high arsenic areas compared to the general population or a low arsenic exposed reference group. The quality assessment showed that, among the studies identified, only four assessed arsenic exposure at the individual level. Further, only one of the ecological studies presented results adjusted for potential confounders other than age; of the cohort and case-control studies, only one-half adjusted for cigarette smoking status in the analysis. Despite these methodologic limitations, the consistent observation of strong, statistically significant associations from different study designs carried out in different regions provide support for a causal association between ingesting drinking water with high concentrations of arsenic and lung cancer. The lung cancer risk at lower exposure concentrations remains uncertain.

Celik, Ismail [Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara (Turkey); Gallicchio, Lisa [Prevention and Research Center, Mercy Medical Center (United States); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Boyd, Kristina; Lam, Tram K.; Matanoski, Genevieve [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Tao Xuguang [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Department of Occupational and Environmental Medicine, Johns Hopkins University School of Medicine (United States); Shiels, Meredith; Hammond, Edward [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Chen Liwei [Department of International Health, Center for Human Nutrition, Johns Hopkins University Bloomberg School of Public Health (United States); Robinson, Karen A. [Department of General Internal Medicine, Johns Hopkins University School of Medicine (United States); Caulfield, Laura E. [Department of International Health, Center for Human Nutrition, Johns Hopkins University Bloomberg School of Public Health (United States); Herman, James G. [Department of Oncology, Johns Hopkins University School of Medicine (United States); Guallar, Eliseo [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Alberg, Anthony J. [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Cancer Prevention and Control Program, Hollings Cancer Center, and Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina (United States)], E-mail: alberg@musc.edu

2008-09-15T23:59:59.000Z

292

Determination of petroleum pipe scale solubility in simulated lung fluid  

E-Print Network (OSTI)

Naturally occurring radioactive material (NORM) exists in connate waters and, under the right conditions during oil drilling, can plate out on the interior surfaces of oil and gas industry equipment. Once deposited, this material is commonly referred to as ??scale.?? This thesis is concerned with the presence of 226Ra in scale deposited on the inner surfaces of oil drilling pipes and the internal dose consequences of inhalation of that scale once released. In the process of normal operation, barium sulfate scale with a radium component adheres to the inside of downhole tubulars in oil fields. When crude flow is diminished below acceptable operational requirements, the pipe is sent to a descaling operation to be cleaned, most likely by a method known as rattling. The rattling process generates dust. This research investigated the chemical composition of that aerosol and measured the solubility of pipe scale from three oilfield formations. Using standard in-vitro dissolution experimental equipment and methods, pipe scale is introduced into simulated lung fluid over a two-week period. These samples are analyzed using quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS), known for very low detection limits. Analysis reveals virtually no 226Ra present in the lung fluid exposed to pipe scale. Sample measurements were compared against background measurements using Student??s t test, which revealed that nearly all the samples were statistically insignificant in comparison to the lung fluid blanks. This statistical test proves within a 95% confidence interval that there is no 226Ra present in the lung fluid samples. These results indicate that inhaled NORM pipe scale should be classified as Class S and serve to further confirm the extreme insolubility of petroleum pipe scale. For dose calculations, the S classification means that the lung is the main organ of concern. Radium-226 from petroleum pipe scale does not solubilize in the interstitial lung fluid, and does not, therefore, enter the bloodstream via respiratory pathways. Since there is no removal by dissolution, the 500 day biological half-life implied by the S classification is based solely on the mechanical transport of 226Ra out of the lungs by phagocytosis or the mucociliary escalator.

Cezeaux, Jason Roderick

2004-08-01T23:59:59.000Z

293

The Unsustainable Rise of the Disability Rolls in the United States: Causes, Consequences, and Policy Options  

E-Print Network (OSTI)

Two ailments limit the effectiveness and threaten the long-term viability of the U.S. Social Security Disability Insurance program (SSDI). First, the program is ineffective in assisting the vast majority of workers with ...

Autor, David

2012-01-24T23:59:59.000Z

294

Good Practice Examples of Work in our Forests (Disability) Initiative/Project  

E-Print Network (OSTI)

disabilities to the facilities and activities at Grizedale Outcome: Attracted 150 people and the event and Vitalise a registered charity based in Churchtown farm, Lanlivery in Cornwall which provide essential

295

Flare system for safe disposal of LNG from a disabled tanker  

SciTech Connect

The feasibility of a flare system for the rapid and safe incineration of the cargo of a disabled LNG tanker is evaluated. The project developed design parameters and proof-of-principle investigations of a system for off-loading and flaring LNG from a disabled LNG tanker. The system described offers enough promise to warrant additional investigation, if cargo burning is desired as a way of reducing other possible hazards.

Not Available

1982-12-01T23:59:59.000Z

296

Low-Dose Spiral CT Scans for Early Lung Cancer Detection | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-dose spiral computed tomography (CT) scanning is a noninvasive medical imaging test that has been used for the early detection of lung cancer for over 16 years (Sone et al. 1998; Henschke et.al. 1999). A low-dose spiral chest CT differs from a full-dose conventional chest CT scan primarily in the amount of radiation emitted during CT scans. Chest CT, in general, requires less radiation exposure than other CT procedures because the air-filled tissues of the lungs are not as dense as the tissues of other organs (i.e., less x-ray radiation is needed to penetrate the lung). Radiation dose can be further reduced with lung cancer screening due to the

297

Low Floor Americans with Disabilities Compliant Alternate Fuel Vehicle Project  

SciTech Connect

This project developed a low emission, cost effective, fuel efficient, medium-duty community/transit shuttle bus that meets American's with Disabilities Act (ADA) requirements and meets National Energy Policy Act requirements (uses alternative fuel). The Low Profile chassis, which is the basis of this vehicle is configured to be fuel neutral to accommodate various alternative fuels. Demonstration of the vehicle in Yellowstone Park in summer (wheeled operation) and winter (track operation) demonstrated the feasibility and flexibility for this vehicle to provide year around operation throughout the Parks system as well as normal transit operation. The unique configuration of the chassis which provides ADA access with a simple ramp and a flat floor throughout the passenger compartment, provides maximum access for all passengers as well as maximum flexibility to configure the vehicle for each application. Because this product is derived from an existing medium duty truck chassis, the completed bus is 40-50% less expensive than existing low floor transit buses, with the reliability and durability of OEM a medium duty truck.

James Bartel

2004-11-26T23:59:59.000Z

298

Barriers to school inclusion : an investigation into the exclusion of disabled students from and within New Zealand schools.  

E-Print Network (OSTI)

??Research evidence suggests that disabled students are experiencing forms of exclusion from and within schools, however little is known of the nature of this phenomenon. (more)

Kearney, Alison

2009-01-01T23:59:59.000Z

299

Characteristics, Welfare Use and Material Hardship Among California AFDC Households with Disabled and Chronically Ill Family Members  

E-Print Network (OSTI)

completed telephone survey o f AFDC-recipient households tocare for disabled members. When AFDC and SSI are consideredfamilies in this sample of AFDC recipient families were very

Meyers, Marcia k.

1996-01-01T23:59:59.000Z

300

Epidermal growth factor receptor expression in radiation-induced dog lung tumors by immunocytochemical localization  

SciTech Connect

In studies to determine the role of growth factors in radiation-induced lung cancer, epidermal growth factor (EGFR) expression was examined by immunocytochemistry in 51 lung tumors from beagle dogs exposed to inhaled plutonium; 21 of 51 (41%) tumors were positive for EGFR. The traction of tumors positive for EGFR and the histological type of EGFR-positive tumors in the plutonium-exposed dogs were not different from spontaneous dog lung tumors, In which 36% were positive for EGFR. EGFR involvement in Pu-induced lung tumors appeared to be similar to that in spontaneous lung tumors. However, EGFR-positive staining was observed in only 1 of 16 tumors at the three lowest Pu exposure levels, compared to 20 of 35 tumors staining positive at the two highest Pu exposure levels. The results in dogs were in good agreement with the expression of EGFR reported in human non-small cell carcinoma of the lung, suggesting that Pu-induced lung tumors in the dog may be a suitable animal model to investigate the role of EGFR expression in lung carcinogenesis. In humans, EGFR expression in lung tumors has been primarily related to histological tumor types. In individual dogs with multiple primary lung tumors, the tumors were either all EGFR positive or EGFR negative, suggesting that EGFR expression may be related to the response of the individual dog as well as to the histological type of tumor.

Leung, F.L.; Park, J.F.; Dagle, G.E.

1993-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Inflammatory response of lung cells exposed to whole, filtered, and  

NLE Websites -- All DOE Office Websites (Extended Search)

Inflammatory response of lung cells exposed to whole, filtered, and Inflammatory response of lung cells exposed to whole, filtered, and hydrocarbon denuded diesel exhaust Title Inflammatory response of lung cells exposed to whole, filtered, and hydrocarbon denuded diesel exhaust Publication Type Journal Article Year of Publication 2007 Authors Holder, Amara L., Donald Lucas, Regine Goth-Goldstein, and Catherine P. Koshland Journal Chemosphere Volume 70 Pagination 13-19 Date Published 09/2007 Keywords air-liquid interface, combustion particle, human bronchial epithelial cells, interleukin-8 Abstract In vitro studies with the organic extracts of diesel particles have suggested that hydrocarbons such as PAH may play a role in an inflammatory response, but these have been limited by the possible artifacts introduced in the particle collection and processing. In this study, we avoid these artifacts and use an activated carbon denuder to remove hydrocarbons from the exhaust stream to investigate their role in the inflammatory response. Human bronchial epithelial cells (16HBE140) were exposed at the air-cell interface to diluted and aged exhaust from a diesel generator operated at partial and no load conditions. When particles were removed with a filter before cell exposure, exhaust gases accounted for almost half of the response compared to the whole exhaust. Removal of gas phase and a portion of the particle phase hydrocarbons with the denuder decreased the interleukin-8 (IL-8) secretion to unexposed levels

302

The Effects of Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effects of Care on Client Mobility: Findings from Contra Costa, California  

E-Print Network (OSTI)

aides caring for elderly and disabled adults (Doctoralcare for the elderly and disabled has not shifted to home-to aged, blind, or disabled persons . . . who are unable to

Decker, Annie

2005-01-01T23:59:59.000Z

303

Columbia Plateau Basin and Fifteenmile Subbasin Water Rights Acquisitons; Oregon Water Trust Combined Work Plan, 2002-2003 Final Report.  

DOE Green Energy (OSTI)

This is the Final Report submitted regarding Oregon Water Trust's Combined Work Plan for fiscal year 2003, with the contract period April 2002 to May 2003. Of this 12 month period, six month were spent concluding our work for the 2002 irrigation season and six months were spent preparing for the 2003 irrigation season. After this grant was completed, projects were finished with funding from the Columbia Basin Water Transactions Program. Many of the 2003 irrigation season successes began in the fall of 2002, when projects were researched and partnerships were developed. Trout Creek Ranch was one of the large successes. During the 2003 irrigation season, 2.6 cfs was leased which led to a permanent instream transfer, protecting critical spawning habitat for summer steelhead in the Deschutes basin. Another success was the Walla Walla Lease Bank project. This project is an agreement between the OWT, the Walla Walla Irrigation District and 11 individual landowners. Through this single year lease, 7.9 cfs of water was legally protected in the Walla Walla River. The Vidando lease on Middle Fork John Day River was renewed for 2 more years, protecting 11.29 cfs. An innovative single year split-season lease was conducted with Voight on Standard Creek in the John Day basin to protect 4.93 cfs. Many other deals were conducted and the total was an impressive 50.43 cfs instream during 2003 and 9.39 cfs pending approval for the 2004 season. Included is a summary of the activities within the Fifteenmile subbasin and the Columbia Plateau basin by quarter and two tables. The summary of activities is broken down by objectives and quarters. The first summarizes the total cfs by type of lease or transfer. The second table lists all the projects by subbasin and provides project type, lease number, cfs, cost of acquisition, partners in the project and funding source.

Paulus, Fritz

2003-12-01T23:59:59.000Z

304

Stem Cell Marker Expression in Mouse Lung after Exposure to Acute...  

NLE Websites -- All DOE Office Websites (Extended Search)

stem cell specific marker expression in mouse lung after whole-body exposure to irradiation with either photons or protons and evaluate modulating effects of preirradiation...

305

A question of visibility: a rights-based look at ICT centers for persons with disabilities in Latin America  

Science Conference Proceedings (OSTI)

In this paper, we examine the deployment of a group of technology centers serving people with disabilities in five Latin American countries: Colombia, Ecuador, Guatemala, Mexico, and Venezuela. We explore the impacts of such training courses on the employability, ... Keywords: ICTD, Latin America, disability, visibility

Michele Frix; Joyojeet Pal

2010-12-01T23:59:59.000Z

306

Smarter finance for cleaner energy: open up master limited partnerships (MLPs) and real estate investment trusts (REITs) to renewable energy investment  

SciTech Connect

Master Limited Partnerships (MLPs) and Real Estate Investment Trusts (REITs)both well-established investment structuresshould be opened up to renewable energy investment. MLPs and, more recently, REITs have a proven track record for promoting oil, gas, and other traditional energy sources. When extended to renewable energy projects these tools will help promote growth, move renewables closer to subsidy independence, and vastly broaden the base of investors in Americas energy economy. The extension of MLPs and REITs to renewables enjoys significant support from the investment and clean energy communities. In addition, MLPs for renewables also enjoy bipartisan political backing in Congress.

Mormann, Feliz; Reicher, Dan

2012-11-15T23:59:59.000Z

307

Cellular morphometry of the bronchi of human and dog lungs  

SciTech Connect

One hundred and forty-seven bronchial samples (generations 3--6) from 66 patients (62 usable; 36 female, 26 male; median age 61) have been dissected by generation from fixed surgical lung specimens obtained after the removal of pathological lesions. In addition, one hundred and fifty-six mongol dog bronchi (generations 2--6) dissected from different lobes of 26 dog lungs have also been similarly prepared. One hundred and twenty-seven human samples have been completely processed for electron microscopy and have yielded 994 electron micrographs of which 655 have been entered into the Computerized Stereological Analysis System (COSAS) and been used for the measurement of the distances of basal and mucous cell nuclei to the epithelial free surface. Similarly 328 micrographs of dog epithelium from 33 bronchial samples have been used to measure the distances of basal and mucous cell nuclei to the epithelial free surface and have been entered into COSAS. Using the COSAS planimetry program, we continue to expand our established data bases which describe the volume density and nuclear numbers per electron micrograph for 5 cell types of the human bronchial epithelial lining of men and women, as well as smokers, non-smokers and ex-smokers and similar parameters for the same 5 epithelial cell types of dog bronchi. Our micrographs of human bronchial epithelium have allowed us to analyze the recent suggestion that the DNA of lymphocytes may be subject to significant damage from Rn progeny while within the lung. Since the last progress report three papers have been submitted for publication. 17 refs., 4 tabs.

Robbins, E.S.

1991-09-01T23:59:59.000Z

308

PET-CTi contribution in staging macronodular versus nodular non small cell lung carcinoma  

Science Conference Proceedings (OSTI)

We analyzed through comparison 2 groups of patients first with nodules smaller than 3 cm (Luzern group) and the second one with nodules lerger than 3cm (Zurich) to assess the role of PET-CTi to the staging of the non small cell lung cancer and to demonstrate ... Keywords: PET-CTi, adenopathy, diagnosis accuracy, lung cancer, tumor staging

Dana Alexandrescu; Milena Man; Bogdan Ra?iu-Duma; Roxana Miclaus

2009-09-01T23:59:59.000Z

309

An optimal tumor marker group-coupled artificial neural network for diagnosis of lung cancer  

Science Conference Proceedings (OSTI)

Background: Epidemiological statistics has shown that there are approximately 1.2 million new cases of lung cancer diagnosed every year and the death rate of these patients is 17.8%. Earlier diagnosis is key to promote the five-year survival rate of ... Keywords: Artificial neural network, Diagnosis, Lung cancer, Tumor marker

Yongjun Wu; Yiming Wu; Jing Wang; Zhen Yan; Lingbo Qu; Bingren Xiang; Yiguo Zhang

2011-09-01T23:59:59.000Z

310

Genome-based identification of diagnostic molecular markers for human lung carcinomas by PLS-DA  

Science Conference Proceedings (OSTI)

Partial least squares discriminant analysis (PLS-DA) provides a sound statistical basis for the selection of a limited number of gene transcripts most effective in discriminating different lung tumoral histotypes. The potentialities of the PLS-DA approach ... Keywords: Cancer diagnostics, Gene transcripts, Lung tumours, PLS-DA, cDNA microarray

Giuseppe Musumarra; Vincenza Barresi; Daniele F. Condorelli; Cosimo G. Fortuna; Salvatore Scir

2005-06-01T23:59:59.000Z

311

Evaluating web site accessibility: validating the WAI guidelines through usability testing with disabled users  

Science Conference Proceedings (OSTI)

The purpose of the reported study has been to validate empirically the usefulness of using the WAI accessibility guidelines WCAG 1.0 as a heuristic for website accessibility. Through controlled usability tests of two websites with disabled users (N=7) ... Keywords: WCAG, accessibility, guidelines, usability, usability testing, validation

Dagfinn Rmen; Dag Svans

2008-10-01T23:59:59.000Z

312

Department of Mechanical Engineering Fall 2012 Roller Coaster Restraint System for Riders with Disabilities  

E-Print Network (OSTI)

the train seat. The estimated cost of implementation is approximately $186.69 excluding labor and machining with Disabilities Overview The restraint system of a roller coaster is one of the most vital pieces of equipment and unloading process. Approach The customer needs were determined through a site visit with Premier Rides

Demirel, Melik C.

313

2D/3D registration algorithm for lung brachytherapy  

Science Conference Proceedings (OSTI)

Purpose: A 2D/3D registration algorithm is proposed for registering orthogonal x-ray images with a diagnostic CT volume for high dose rate (HDR) lung brachytherapy. Methods: The algorithm utilizes a rigid registration model based on a pixel/voxel intensity matching approach. To achieve accurate registration, a robust similarity measure combining normalized mutual information, image gradient, and intensity difference was developed. The algorithm was validated using a simple body and anthropomorphic phantoms. Transfer catheters were placed inside the phantoms to simulate the unique image features observed during treatment. The algorithm sensitivity to various degrees of initial misregistration and to the presence of foreign objects, such as ECG leads, was evaluated. Results: The mean registration error was 2.2 and 1.9 mm for the simple body and anthropomorphic phantoms, respectively. The error was comparable to the interoperator catheter digitization error of 1.6 mm. Preliminary analysis of data acquired from four patients indicated a mean registration error of 4.2 mm. Conclusions: Results obtained using the proposed algorithm are clinically acceptable especially considering the complications normally encountered when imaging during lung HDR brachytherapy.

Zvonarev, P. S. [McMaster University, Medical Physics and Applied Radiation Sciences, Hamilton, Ontario L8S 4L8 (Canada); Farrell, T. J.; Hunter, R.; Wierzbicki, M.; Hayward, J. E. [McMaster University, Medical Physics and Applied Radiation Sciences, Hamilton, Ontario L8S 4L8 (Canada); Juravinski Cancer Centre, Medical Physics, Hamilton, Ontario L8V 5C2 (Canada); Sur, R. K. [McMaster University, Medical Physics and Applied Radiation Sciences, Hamilton, Ontario L8S 4L8 (Canada); Juravinski Cancer Centre, Radiation Oncology, Hamilton, Ontario L8V 5C2 (Canada)

2013-02-15T23:59:59.000Z

314

Oxidative Stress Mediates Radiation Lung Injury by Inducing Apoptosis  

SciTech Connect

Purpose: Apoptosis in irradiated normal lung tissue has been observed several weeks after radiation. However, the signaling pathway propagating cell death after radiation remains unknown. Methods and Materials: C57BL/6J mice were irradiated with 15 Gy to the whole thorax. Pro-apoptotic signaling was evaluated 6 weeks after radiation with or without administration of AEOL10150, a potent catalytic scavenger of reactive oxygen and nitrogen species. Results: Apoptosis was observed primarily in type I and type II pneumocytes and endothelium. Apoptosis correlated with increased PTEN expression, inhibition of downstream PI3K/AKT signaling, and increased p53 and Bax protein levels. Transforming growth factor-{beta}1, Nox4, and oxidative stress were also increased 6 weeks after radiation. Therapeutic administration of AEOL10150 suppressed pro-apoptotic signaling and dramatically reduced the number of apoptotic cells. Conclusion: Increased PTEN signaling after radiation results in apoptosis of lung parenchymal cells. We hypothesize that upregulation of PTEN is influenced by Nox4-derived oxidative stress. To our knowledge, this is the first study to highlight the role of PTEN in radiation-induced pulmonary toxicity.

Zhang Yu; Zhang Xiuwu; Rabbani, Zahid N. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Jackson, Isabel L. [Department of Pathology, Duke University Medical Center, Durham, NC (United States); Vujaskovic, Zeljko, E-mail: vujas@radonc.duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Department of Pathology, Duke University Medical Center, Durham, NC (United States)

2012-06-01T23:59:59.000Z

315

The Effects of Structured Work Experience on the Work-Readiness Skills of Students with Disabilities  

E-Print Network (OSTI)

It is common knowledge that employment is a large part of participation in society for all adults; and, one role of public education is to prepare students for these adult roles. Despite increasing school accountability measures for post-school outcomes of students with disabilities, a significant gap in employment between those with and those without disabilities remains. Work experience during high school has been established as the most consistent predictor of post-school employment. The problem is the lack of intervention research demonstrating ways of implementing programs that are associated with acquisition of work-readiness skills. The purpose of this study was to investigate the effects of structured work experience on the work-readiness skills of students with disabilities, and examine whether or not disability, or type of program, affected student outcomes while controlling for number of participant contact hours. To accomplish this purpose, a quasi- experimental one-group pretest-posttest design was selected and used. The target population for this study was high school students with disabilities in three high schools in Texas. The final sample included 37 students. The Becker Work Adjustment Profile: 2 was the instrument used to measure the participants work-readiness skills. The pretest was administered within two weeks of student entry into the program. The posttest was administered within two weeks of student exit from the program. Descriptive and inferential analyses were conducted to answer the primary and exploratory research questions. Inferential analyses included a dependent sample t test and an ANCOVA using number of participant contact hours as the covariate. Results indicated participation in a structured work experience program had a positive effect on the work-readiness skills of these participants. ANCOVA results indicated (a) disability type was not a significant factor affecting the work-readiness of the participants, (b) program type produced a statistically significant main effect, (c) there was no statistically significant interaction effect between disability type and program type, and (d) number of contact hours produced a statistically significant main effect. Future research studies should focus on replication of the current study results and examination of the long-term effects of participation in structured work experience programs on post-school outcomes.

Pacha, Jacqueline K

2013-05-01T23:59:59.000Z

316

Trusted Computing Overview  

Science Conference Proceedings (OSTI)

... No insecure flash locking mechanisms Page 25. COMPLIANCE Currently self-certifying Windows Hardware Certification Requirements ...

2012-11-02T23:59:59.000Z

317

From Newton to Hawking and beyond: Why disability equality is relevant to the world of particle physics - by Dr T. Shakespeare  

E-Print Network (OSTI)

According to the recent World report on disability, 15% of the worlds population is disabled. Among that group could be numbered famous physicists such as Isaac Newton, Paul Dirac & Stephen Hawking. This presentation will provide some basic data about global disability, and the socially-imposed barriers which disabled people face.It will also offer some practical suggestions on how to respect and include people with disabilities in the workplace. Tom Shakespeare is a social scientist and ethicist with 25 years experience with the disability movement. Between 2008-2013, Tom worked in the Disability and Rehabilitation team at the World Health Organization, Geneva. He currently teaches medical sociology at the University of East Anglia Medical School, in Norwich, UK.

CERN. Geneva

2013-01-01T23:59:59.000Z

318

KUMC believes the success of its research depends on the quality of the partnership between you, the study volunteers, and the investigators at KUMC a partnership based on mutual trust and the best available information.  

E-Print Network (OSTI)

KUMC believes the success of its research depends on the quality of the partnership between you, the study volunteers, and the investigators at KUMC ­ a partnership based on mutual trust and the best assigned (like flipping a coin) to either receive a study drug or a placebo (a substance with no active

Albertini, David

319

{sup 222}Rn dosimetry in the dog lung  

SciTech Connect

The alpha dose to cells in bronchial airways in the beagle dog during historical exposures to {sup 222}Rn decay products is calculated using updated information on airway morphometry, call nucleus depth, mucus thickness, physical dosimetry and atmospheric characteristics. The alpha dose per unit exposure to basal call nuclei in the upper airways ranges from 2 to 7 mGy WLM{sup {minus}1} (excluding the trachea) depending upon the exposure protocol used. The dose to alveolar tissue is 3 mGy WLM{sup {minus}1}. In the human lung, the dose factor for the bronchial airways is 9 mGy WLM{sub {minus}1} and for the pulmonary parenchyma 0.5 mGy WLM{sup {minus}1} The human tumors appear primarily in the first few branching airway generations while the only tumors observed in the animals were in the bronchioloalveolar region suggesting a difference in cell sensitivity to alpha radiation.

Harley, N.H.; Meyers, O.A.; Robbins, E.S.

1991-12-31T23:59:59.000Z

320

[sup 222]Rn dosimetry in the dog lung  

SciTech Connect

The alpha dose to cells in bronchial airways in the beagle dog during historical exposures to [sup 222]Rn decay products is calculated using updated information on airway morphometry, call nucleus depth, mucus thickness, physical dosimetry and atmospheric characteristics. The alpha dose per unit exposure to basal call nuclei in the upper airways ranges from 2 to 7 mGy WLM[sup [minus]1] (excluding the trachea) depending upon the exposure protocol used. The dose to alveolar tissue is 3 mGy WLM[sup [minus]1]. In the human lung, the dose factor for the bronchial airways is 9 mGy WLM[sub [minus]1] and for the pulmonary parenchyma 0.5 mGy WLM[sup [minus]1] The human tumors appear primarily in the first few branching airway generations while the only tumors observed in the animals were in the bronchioloalveolar region suggesting a difference in cell sensitivity to alpha radiation.

Harley, N.H.; Meyers, O.A.; Robbins, E.S.

1991-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Cellular morphometry of the bronchi of human and dog lungs  

SciTech Connect

Quantitative data of the human bronchial epithelial cells at possible risk for malignant transformation in lung cancer is crucial for accurate radon dosimetry and risk analysis. The locations and other parameters of the nuclei which may be damaged by [alpha] particles must be determined and compared in different airway generations, among smokers, non-smokers and ex-smokers, between men and women and in people of different ages. This proposal includes extended morphometric studies on electron micrographs of human epithelium of defined airway generations and in parallel on electron micrographs of the dog bronchial lining. The second part of this proposal describes studies to quantitate the cycling bronchial epithelial population(s) using proliferation markers and immunocytochemistry on frozen and paraffin sections and similar labeling of isolated bronchial epithelial cells sorted flow cytometry.

Robbins, E.S.

1992-09-01T23:59:59.000Z

322

Expression of hPNAS-4 Radiosensitizes Lewis Lung Cancer  

SciTech Connect

Purpose: This study aimed to transfer the hPNAS-4 gene, a novel apoptosis-related human gene, into Lewis lung cancer (LL2) and observe its radiosensitive effect on radiation therapy in vitro and in vivo. Methods and Materials: The hPNAS-4 gene was transfected into LL2 cells, and its expression was detected via western blot. Colony formation assay and flow cytometry were used to detect the growth and apoptosis of cells treated with irradiation/PNAS-4 in vitro. The hPNAS-4 gene was transferred into LL2-bearing mice through tail vein injection of the liposome/gene complex. The tumor volumes were recorded after radiation therapy. Proliferating cell nuclear antigen (PCNA) immunohistochemistry staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were performed to detect the tumor cell growth and apoptosis in vivo. Results: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue, and its overexpressions were confirmed via western blot analysis. Compared with the control, empty plasmid, hPNAS-4, radiation, and empty plasmid plus radiation groups, the hPNAS-4 plus radiation group more significantly inhibited growth and enhanced apoptosis of LL2 cells in vitro and in vivo (P<.05). Conclusions: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue and was expressed in both LL2 cell and tumor tissue. The hPNAS-4 gene therapy significantly enhanced growth inhibition and apoptosis of LL2 tumor cells by radiation therapy in vitro and in vivo. Therefore, it may be a potential radiosensitive treatment of radiation therapy for lung cancer.

Zeng Hui [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Yuan Zhu [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Zhu Hong [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Lei; Shi Huashan [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Wang Zi; Fan Yu; Deng Qian; Zeng Jianshuang; He Yinbo [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Xiao Jianghong [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Zhiping, E-mail: lizhiping620312@yahoo.com.cn [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)

2012-11-15T23:59:59.000Z

323

National Nuclear Security Administration Contractors' Disability Compensation and Return-to-Work Programs, IG-0867  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Audit Report Audit Report The National Nuclear Security Administration Contractors' Disability Compensation and Return-to-Work Programs DOE/IG-0867 June 2012 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 June 18, 2012 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Audit Report on "NNSA Contractors' Disability Compensation and Return-to-Work Programs" INTRODUCTION AND OBJECTIVE The Department of Energy's National Nuclear Security Administration is responsible for the Nation's nuclear weapons programs. NNSA relies on contractors to manage and operate the seven sites that form its nuclear security enterprise, including three national laboratories. Under

324

Librarians and the Entrepreneurship Bootcamp for Veterans: Helping Disabled Veterans With Business Research  

E-Print Network (OSTI)

The Entrepreneurship Bootcamp for Veterans with Disabilities is a national educational program that helps post-9/11 Veterans accomplish their dreams of starting their own businesses. Although their story has been well documented, one story that has not been told is that of a group of business librarians who support the program. The authors present unique services and resources made available to participants of this program and discuss some of the challenges, results, and future aspirations of library support.

Hoppenfeld, Jared; Wyckoff, Trip; Henson, Jo Ann J.; Mayotte, Jenna N.; Kirkwood, Hal P. Jr.

2013-01-01T23:59:59.000Z

325

Evaluating the controlled release properties of inhaled nanoparticles using isolated, perfused, and ventilated lung models  

Science Conference Proceedings (OSTI)

Polymeric nanoparticles meet the increasing interest for inhalation therapy and hold great promise to improve controlled drug delivery to the lung. The synthesis of tailored polymeric materials and the improvement of nanoparticle preparation techniques ...

Moritz Beck-Broichsitter; Thomas Schmehl; Werner Seeger; Tobias Gessler

2011-01-01T23:59:59.000Z

326

Lung cancer epidemiology in New Mexico uranium miners. Progress report, March 1, 1991--November 30, 1991  

Science Conference Proceedings (OSTI)

This investigation assesses the health effects of radon progeny exposure in New Mexico uranium miners. Cumulative exposures sustained by most New Mexico miners are well below those received earlier in the Colorado Plateau. This project utilizes the research opportunity offered by New Mexico miners to address unresolved issues related to radon progeny exposure: (1) the lung cancer risk of lower levels of exposure, (2) interaction between radon progeny exposure and cigarette smoking in the causation of lung cancer, (3) the relationship between lung cancer histologic type and radon progeny exposure, and (4) possible effects of radon progeny exposure other than lung cancer. A cohort study of 3800 men with at least one year of underground uranium mining experience in New Mexico is in progress. Results are discussed.

Samet, J.M.

1991-11-01T23:59:59.000Z

327

Former Worker Program - Low-Dose Spiral CT Scans for Early Lung...  

NLE Websites -- All DOE Office Websites (Extended Search)

of radiation emitted during CT scans. Chest CT, in general, requires less radiation exposure than other CT procedures because the air-filled tissues of the lungs are not as dense...

328

U-bearing particles in miners' and millers' lungs  

SciTech Connect

The size distribution of uranium-bearing particles in air particulates in occupational areas of active uranium mines and mills is largely uninvestigated. Investigation of the size of residual uranium-bearing particles in uranium miners' and millers' lungs is warranted because significant inhalation of uranium can occur in certain occupational areas. Average uranium concentrations of about 0.3 ppM U in uranium miners' and millers' lungs have been reported. Local uranium concentrations in uranium-bearing particles inhaled and regionally deposited in the lungs of uranium miners and millers are orders of magnitude larger than the average uranium concentrations reported. The feasibility of using microPIXE (particle induced x-ray emission) techniques to search for such uranium-bearing particles embedded in lung tissues has been demonstrated. Proton microbeams 20 ..mu..m in diameter, scanning in 5 ..mu..m steps, were used to irradiate sections of lung tissues 10 to 40 ..mu..m thick. The paper will briefly describe the method, and present and discuss the results obtained in an extensive search for uranium-bearing particles embedded in lung tissues, collected at autopsy, of former uranium miners and millers. 13 references, 1 table.

Paschoa, A.S.; Wrenn, M.E.; Singh, N.P.; Miller, S.C.; Jones, K.W.; Cholewa, M.; Hanson, A.L.; Saccomanno, G.

1984-01-01T23:59:59.000Z

329

Supine lung clearance of Tc-99m DTPA and HMPAO aerosols  

Science Conference Proceedings (OSTI)

The speed of Tc-99m DTPA/HMPAO radioaerosol clearance from the lungs that is represented as a slope from lungs to blood was measured in 23 male normal controls using commercial lung radioaerosol delivery units in the supine position in order to avoid the influences of gravity. The right lung was selected and three regions of interest were created for equal subdivisions of the upper, middle, and lower third. The results show that the clearance of Tc-99m DTPA/HMPAO aerosols in the upper lung is lowest. The difference between upper and lower lungs for Tc-99m DTPA/HMPAO aerosol clearances are significant. The clearance of Tc-99m DTPA aerosols was significantly faster than those of Tc-99m HMPAO in any region. The authors conclude that, although the effect of gravity disappears in the supine position in our study, the differences of aerosol clearance in different regions are still significant. Lipophilic Tc-99m HMPAO aerosols were slower than those of hydrophilic Tc-99m DTPA, which suggests there are at least two different mechanisms. 22 refs., 2 figs., 1 tab.

Chia-Hung Kao; Hui-Tzu Lin; Shu-Ling Yu [Taichung Veterans General Hospital (Taiwan, Province of China)] [and others

1995-07-01T23:59:59.000Z

330

Recommended emergency preparedness guidelines for elderly and disabled rail-transit passengers. Final report, November 1987-March 1989  

Science Conference Proceedings (OSTI)

Rail transit has become an important source of transportation for many elderly and disabled persons. The principal reasons for the increased use are improved accessibility, low cost, and expanded areas of service. For the purposes of the report, 'elderly' is defined as any member of the population who is 60 years of age or older, and 'disabled' is defined as any person who has some type of disability. The Urban Mass Transportation Administration (UMTA) has recognized the need to consider the unique characteristics of elderly and disabled passengers in rail-transit emergency response planning. The needs of these passengers can be addressed through carefully planned emergency response procedures, proper training of transit and emergency-response personnel, and effective use of equipment. The recommendations contained herein are therefore intended to assist rail-transit and emergency response organization personnel in evaluating their emergency response plans in terms of the needs of elderly and disabled passengers and, if necessary, to modify or supplement those plans accordingly. The report is intended to supplement the UMTA publication Recommended Emergency Preparedness Guidelines for Rail Transit Systems. That report contains general guidelines designed to assist rail-transit systems in assessing, developing, documenting, and improving their capabilities for responding to emergencies and in coordinating those efforts with emergency response organizations.

Hathaway, W.T.; Markos, S.H.; Balog, J.N.

1989-08-01T23:59:59.000Z

331

Quantitative Assessment of Range Fluctuations in Charged Particle Lung Irradiation  

SciTech Connect

Purpose: Water equivalent path length (WEL) variations due to respiration can change the range of a charged particle beam and result in beam overshoot to critical organs or beam undershoot to tumor. We have studied range fluctuations by analyzing four-dimensional computed tomography data and quantitatively assessing potential beam overshoot. Methods and Materials: The maximal intensity volume is calculated by combining the gross tumor volume contours at each respiratory phase in the four-dimensional computed tomography study. The first target volume calculates the maximal intensity volume for the entire respiratory cycle (internal target volume [ITV]-radiotherapy [RT]), and the second target volume is the maximal intensity volume corresponding to gated RT (gated-RT, {approx}30% phase window around exhalation). A compensator at each respiratory phase is calculated. Two 'composite' compensators for ITV-RT and gated-RT are then designed by selecting the minimal compensator depth at the respective respiratory phase. These compensators are then applied to the four-dimensional computed tomography data to estimate beam penetration. Analysis metrics include range fluctuation and overshoot volume, both as a function of gantry angle. We compared WEL fluctuations observed in treating the ITV-RT versus gated-RT in 11 lung patients. Results: The WEL fluctuations were <21.8 mm-WEL and 9.5 mm-WEL for ITV-RT and gated-RT, respectively for all patients. Gated-RT reduced the beam overshoot volume by approximately a factor of four compared with ITV-RT. Such range fluctuations can affect the efficacy of treatment and result in an excessive dose to a distal critical organ. Conclusion: Time varying range fluctuation analysis provides information useful for determining appropriate patient-specific treatment parameters in charged particle RT. This analysis can also be useful for optimizing planning and delivery.

Mori, Shinichiro [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States)], E-mail: shinshin@nirs.go.jp; Wolfgang, John; Lu, H.-M.; Schneider, Robert; Choi, Noah C.; Chen, George T.Y. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States)

2008-01-01T23:59:59.000Z

332

Study of conditions of use of E-services accessible to visually disabled persons  

E-Print Network (OSTI)

The aim of this paper is to determine the expectations that French-speaking disabled persons have for electronic administrative sites (utility). At the same time, it is a matter of identifying the difficulties of use that the manipulation of these E-services poses concretely for blind people (usability) and of evaluating the psychosocial impacts on the way of life of these people with specific needs. We show that the lack of numerical accessibility is likely to accentuate the social exclusion of which these people are victim by establishing a numerical glass ceiling.

Bobiller-Chaumon, Marc-Eric; Sandoz-Guermond, Franoise

2007-01-01T23:59:59.000Z

333

Prince William Sound disabled tanker towing study. Part 1. Evaluation of existing equipment, personnel and procedures  

Science Conference Proceedings (OSTI)

The study has been undertaken by the Glosten Associates, Inc., to evaluate the existing capability for emergency towing at Prince William Sound and to examine alternatives that could enhance the escort and assist capabilities for disabled tankers within the waterway from the Alyeska Oil Terminal at the Port of Valdez to the Gulf of Alaska outside Hinchinbrook Entrance. Part 1, reported herein, is an objective evaluation by an experienced salvage towing master of the existing tugs, emergency towing equipment, towing practices, and discussion of alternative tug types.

Not Available

1993-08-01T23:59:59.000Z

334

Reproducibility of Interfraction Lung Motion Probability Distribution Function Using Dynamic MRI: Statistical Analysis  

SciTech Connect

Purpose: To investigate the statistical reproducibility of craniocaudal probability distribution function (PDF) of interfraction lung motion using dynamic magnetic resonance imaging. Methods and Materials: A total of 17 subjects, 9 healthy volunteers and 8 lung tumor patients, underwent two to three continuous 300-s magnetic resonance imaging scans in the sagittal plane, repeated 2 weeks apart. Three pulmonary vessels from different lung regions (upper, middle, and lower) in the healthy subjects and lung tumor patients were selected for tracking, and the displacement PDF reproducibility was evaluated as a function of scan time and frame rate. Results: For both healthy subjects and patients, the PDF reproducibility improved with increased scan time and converged to an equilibrium state during the 300-s scan. The PDF reproducibility at 300 s (mean, 0.86; range, 0.70-0.96) were significantly (p < 0.001) increased compared with those at 5 s (mean, 0.65; range, 0.25-0.79). PDF reproducibility showed less sensitivity to imaging frame rates that were >2 frames/s. Conclusion: A statistically significant improvement in PDF reproducibility was observed with a prolonged scan time among the 17 participants. The confirmation of PDF reproducibility over times much shorter than stereotactic body radiotherapy delivery duration is a vital part of the initial validation process of probability-based treatment planning for stereotactic body radiotherapy for lung cancer.

Cai Jing; Read, Paul W.; Larner, James M. [Department of Radiation Oncology, University of Virginia, Charlottesville, VA (United States); Jones, David R. [Department of Surgery, University of Virginia, Charlottesville, VA (United States); Benedict, Stanley H. [Department of Radiation Oncology, University of Virginia, Charlottesville, VA (United States); Sheng Ke [Department of Radiation Oncology, University of Virginia, Charlottesville, VA (United States)], E-mail: ks2mc@virginia.edu

2008-11-15T23:59:59.000Z

335

Computed axial tomography (CAT) contribution for dosimetry and treatment evaluation in lung cancer  

SciTech Connect

The use of computed axial tomography (CAT) scans in postoperative patients with lung cancer was studied to evaluate its contribution in dosimetry and to study the late effects of irradiation. Comparisons were made between the treatment planning generated from CAT scan data and that obtained from two orthogonal radiographs. Both methods offered a good approximation but with orthogonal radiographs possible mediastinal and lung shift could not be seen and the dose delivered to the spinal cord was overestimated. A control CAT scan performed 6 to 18 months after treatment showed a lung fibrosis that was strictly correlated with the treatment planning and related with doses and volume treated. CAT scans allowed more accurate treatment planning.

Van Houtte, P.; Piron, A.; Lustman-Marechal, J.; Osteaux, M.; Henry, J.

1980-08-01T23:59:59.000Z

336

Trigger-disabling Acquisition System for Quantum Key Distribution failsafe against Self-blinding  

E-Print Network (OSTI)

Modern single-photon detectors based on avalanche photodiodes offer increasingly higher triggering speeds, thus fostering their use in several fields, prominently in the recent area of Quantum Key Distribution. To reduce the probability of an afterpulse, these detectors are usually equipped with a circuitry that disables the trigger for a certain time after a positive detection event, known as dead time. If the acquisition system connected to the detector is not properly designed, efficiency issues arise when the triggering rate is faster than the inverse of detector's dead-time. Moreover, when this happens with two or more detectors used in coincidence, a security risk called "self-blinding" can jeopardize the distribution of a secret quantum key. In this paper we introduce a trigger-disabling circuitry based on an FPGA-driven feedback loop, so to avoid the above-mentioned inconveniences. In the regime of single-photon-attenuated light, the electronics dynamically accept a trigger only after detectors' compl...

Bawaj, M; Natali, R; Di Giuseppe, G; Tombesi, P

2011-01-01T23:59:59.000Z

337

Trigger-disabling Acquisition System for Quantum Key Distribution failsafe against Self-blinding  

E-Print Network (OSTI)

Modern single-photon detectors based on avalanche photodiodes offer increasingly higher triggering speeds, thus fostering their use in several fields, prominently in the recent area of Quantum Key Distribution. To reduce the probability of an afterpulse, these detectors are usually equipped with a circuitry that disables the trigger for a certain time after a positive detection event, known as dead time. If the acquisition system connected to the detector is not properly designed, efficiency issues arise when the triggering rate is faster than the inverse of detector's dead-time. Moreover, when this happens with two or more detectors used in coincidence, a security risk called "self-blinding" can jeopardize the distribution of a secret quantum key. In this paper we introduce a trigger-disabling circuitry based on an FPGA-driven feedback loop, so to avoid the above-mentioned inconveniences. In the regime of single-photon-attenuated light, the electronics dynamically accept a trigger only after detectors' complete recovery from dead-time. This technique proves useful to work with detectors at their maximum speed and to increase the security of a quantum key distribution setup.

M. Bawaj; M. Lucamarini; R. Natali; G. Di Giuseppe; P. Tombesi

2011-10-25T23:59:59.000Z

338

Lung Density Changes After Stereotactic Radiotherapy: A Quantitative Analysis in 50 Patients  

Science Conference Proceedings (OSTI)

Purpose: Radiologic lung density changes are observed in more than 50% of patients after stereotactic body radiotherapy (SBRT) for lung cancer. We studied the relationship between SBRT dose and posttreatment computed tomography (CT) density changes, a surrogate for lung injury. Methods and Materials: The SBRT fractionation schemes used to treat Stage I lung cancer with RapidArc were three fractions of 18 Gy, five fractions of 11 Gy, or eight fractions of 7.5 Gy, prescribed at the 80% isodose. Follow-up CT scans performed at less than 6 months (n = 50) and between 6 and 9 months (n = 30) after SBRT were reviewed. Posttreatment scans were coregistered with baseline scans using a B-spline deformable registration algorithm. Voxel-Hounsfield unit histograms were created for doses between 0.5 and 50 Gy. Linear mixed effects models were used to assess the effects of SBRT dose on CT density, and the influence of possible confounders was tested. Results: Increased CT density was associated with higher dose, increasing planning target volume size, and increasing time after SBRT (all p 6 Gy, were most prominent in areas receiving >20 Gy, and seemed to plateau above 40 Gy. In regions receiving >36 Gy, the reduction in air-filled fraction of lung after treatment was up to 18%. No increase in CT density was observed in the contralateral lung receiving {>=}3 Gy. Conclusions: A dose-response relationship exists for quantitative CT density changes after SBRT. A threshold of effect is seen at low doses, and a plateau at highest doses.

Palma, David A., E-mail: david.palma@uwo.ca [Department of Radiation Oncology, VU University Medical Center, Amsterdam (Netherlands); Soernsen de Koste, John van; Verbakel, Wilko F.A.R. [Department of Radiation Oncology, VU University Medical Center, Amsterdam (Netherlands); Vincent, Andrew [Department of Biometrics, Netherlands Cancer Institute, Amsterdam (Netherlands); Senan, Suresh [Department of Radiation Oncology, VU University Medical Center, Amsterdam (Netherlands)

2011-11-15T23:59:59.000Z

339

Assistive technologies for the disabled and for the new generation of senior citizens: the e-Tools architecture  

Science Conference Proceedings (OSTI)

In this paper we present our exploratory ideas about the integration of agent technology with other technologies to build specific e-tools for the disabled and for the new generation of senior citizens. e-Tools stands for Embedded Tools, ... Keywords: Assistive technologies, agents, situated intelligence

Ulises Corts; Roberta Annicchiarico; Javier Vzquez-Salceda; Cristina Urdiales; Lola Caamero; Maite Lpez; Miquel Snchez-Marr; Carlo Caltagirone

2003-08-01T23:59:59.000Z

340

The Analysis and Assessment of Adjustment of Selected Web Sites and Web Browsers to the Needs of People with Disabilities  

Science Conference Proceedings (OSTI)

In the 21st century internet is becoming an indispensable element of every person's life. Frequently internet is the basic source of information. Moreover it enables communication, making financial transactions, shopping, etc. Unfortunately in many cases ... Keywords: disabled people, internet standards, user interface, web browsers, web sites

Aleksandra Polak-Sopi?ska; Zbigniew Wi?niewski

2009-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
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341

Radiation-induced lung injury using a pig model: Evaluation by high-resolution computed tomography  

Science Conference Proceedings (OSTI)

To assess the early phase of radiation-induced lung injury using high-resolution computed tomography (CT) under experimental conditions and to perform precise CT-pathologic correlation. Five Yorkshire pigs received a single dose of 12.5 Gy to the right lower lung. Computed tomographic images were obtained at 2-week intervals. The animals were killed after follow-up periods of 4-16 weeks. The lungs were removed, inflated, fixed, dried, and sliced corresponding to the CT sections. Computed tomography, specimen radiography, and histologic findings were correlated. Various CT findings were observed during the first 16 weeks, including ground-glass opacity, discrete consolidation, patchy consolidation, thickened interlobular septum, and bronchovascular bundle. Ground-glass opacity was associated with thickened alveolar wall and scattered tiny fibrotic foci. Thickened interlobular septum and bronchovascular bundle were the results of fibrosis adjacent to these structures. Discrete consolidation correlated with intraalveolar edema with hemorrhage and infiltration of inflammatory cells. High-resolution CT correlated well with pathology of the lung due to radiation injury as verified by precise radiologic-pathologic correlation. 28 refs., 4 figs., 1 tab.

Takahashi, Masashi; Balazs, G.; Moskowitz, G.W.; Palestro, C.J.; Eacobacci, T.; Khan, A.; Herman, P.G. [Albert Einstein College of Medicine, New Hyde Park, NY (United States)

1995-02-01T23:59:59.000Z

342

Liver Hydatid Cyst with Transdiaphragmatic Rupture and Lung Hydatid Cyst Ruptured into Bronchi and Pleural Space  

SciTech Connect

The aim of this case study is to present effectiveness of percutaneous drainage as a treatment option of ruptured lung and liver hydatid cysts. A 65-year-old male patient was admitted with complicated liver and lung hydatid cysts. A liver hydatid cyst had ruptured transdiaphragmatically, and a lung hydatid cyst had ruptured both into bronchi and pleural space. The patient could not undergo surgery because of decreased respiratory function. Both cysts were drained percutaneously using oral albendazole. Povidone-iodine was used to treat the liver cyst after closure of the diaphragmatic rupture. The drainage was considered successful, and the patient had no recurrence of signs and symptoms. Clinical, laboratory, and radiologic recovery was observed during 2.5 months of catheterization. The patient was asymptomatic after catheter drainage. No recurrence was detected during 86 months of follow-up. For inoperable patients with ruptured liver and lung hydatid cysts, percutaneous drainage with oral albendazole is an alternative treatment option to surgery. The percutaneous approach can be life-saving in such cases.

Ar Latin-Small-Letter-Dotless-I bas, Bilgin Kadri, E-mail: bilginaribas@hotmail.com; Dingil, Guerbuez [A.Y. Ankara Oncology Training and Research Hospital, Department of Radiology (Turkey); Koeroglu, Mert [Sueleyman Demirel University School of Medicine, Department of Radiology (Turkey); Uenguel, Uemit; Zaral Latin-Small-Letter-Dotless-I , Aliye Ceylan [A.Y. Ankara Oncology Training and Research Hospital, Department of Radiology (Turkey)

2011-02-15T23:59:59.000Z

343

Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura  

E-Print Network (OSTI)

) was coupled to the system to elucidate the location of the sampling site. Flexible fiberoptic OCT probes be determined. A flexible fiberoptic probe was inserted into the endotracheal tube. The visible laser light coherence tomographic system constructed in our laboratory. Lungs and pleural tissue were subsequently

Chen, Zhongping

344

Three-Dimensional Volumetric Analysis of Irradiated Lung With Adjuvant Breast Irradiation  

Science Conference Proceedings (OSTI)

Purpose: To retrospectively evaluate the dose-volume histogram data of irradiated lung in adjuvant breast radiotherapy (ABR) using a three-dimensional computed tomography (3D-CT)-guided planning technique; and to investigate the relationship between lung dose-volume data and traditionally used two-dimensional (2D) parameters, as well as their correlation with the incidence of steroid-requiring radiation pneumonitis (SRRP). Methods and Materials: Patients beginning ABR between January 2005 and February 2006 were retrospectively reviewed. Patients included were women aged >=18 years with ductal carcinoma in situ or Stage I-III invasive carcinoma, who received radiotherapy using a 3D-CT technique to the breast or chest wall (two-field radiotherapy [2FRT]) with or without supraclavicular irradiation (three-field radiotherapy [3FRT]), to 50 Gy in 25 fractions. A 10-Gy tumor-bed boost was allowed. Lung dose-volume histogram parameters (V{sub 10}, V{sub 20}, V{sub 30}, V{sub 40}), 2D parameters (central lung depth [CLD], maximum lung depth [MLD], and lung length [LL]), and incidence of SRRP were reported. Results: A total of 89 patients met the inclusion criteria: 51 had 2FRT, and 38 had 3FRT. With 2FRT, mean ipsilateral V{sub 10}, V{sub 20}, V{sub 30}, V{sub 40} and CLD, MLD, LL were 20%, 14%, 11%, and 8% and 2.0 cm, 2.1 cm, and 14.6 cm, respectively, with strong correlation between CLD and ipsilateral V{sub 10-V40} (R{sup 2} = 0.73-0.83, p < 0.0005). With 3FRT, mean ipsilateral V{sub 10}, V{sub 20}, V{sub 30}, and V{sub 40} were 30%, 22%, 17%, and 11%, but its correlation with 2D parameters was poor. With a median follow-up of 14.5 months, 1 case of SRRP was identified. Conclusions: With only 1 case of SRRP observed, our study is limited in its ability to provide definitive guidance, but it does provide a starting point for acceptable lung irradiation during ABR. Further prospective studies are warranted.

Teh, Amy Yuen Meei, E-mail: amy.teh@petermac.or [Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Park, Eileen J.H. [Department of Radiation Oncology, The Cancer Institute, National University Hospital (Singapore); Shen Liang [Biostatistics Unit, Yang Loo Ling School of Medicine, National University of Singapore (Singapore); Chung, Hans T. [Department of Radiation Oncology, The Cancer Institute, National University Hospital (Singapore)

2009-12-01T23:59:59.000Z

345

CT appearance of radiation injury of the lung and clinical symptoms after stereotactic body radiation therapy (SBRT) for lung cancers: Are patients with pulmonary emphysema also candidates for SBRT for lung cancers?  

SciTech Connect

Purpose: The purpose of this study was to analyze the computed tomographic (CT) appearance of radiation injury to the lung and clinical symptoms after stereotactic body radiation therapy (SBRT) and evaluate the difference by the presence of pulmonary emphysema (PE) for small lung cancers. Methods and Materials: In this analysis, 45 patients with 52 primary or metastatic lung cancers were enrolled. We evaluated the CT appearance of acute radiation pneumonitis (within 6 months) and radiation fibrosis (after 6 months) after SBRT. Clinical symptoms were evaluated by Common Terminology Criteria for Adverse Events, version 3.0. We also evaluated the relationship between CT appearance, clinical symptoms, and PE. Results: CT appearance of acute radiation pneumonitis was classified as follows: (1) diffuse consolidation, 38.5%; (2) patchy consolidation and ground-glass opacities (GGO), 15.4%; (3) diffuse GGO, 11.5%; (4) patchy GGO, 2.0%; (5) no evidence of increasing density, 32.6%. CT appearance of radiation fibrosis was classified as follows: (1) modified conventional pattern, 61.5%; (2) mass-like pattern, 17.3%; (3) scar-like pattern, 21.2%. Patients who were diagnosed with more than Grade 2 pneumonitis showed significantly less no evidence of increased density pattern and scar-like pattern than any other pattern (p = 0.0314, 0.0297, respectively). Significantly, most of these patients with no evidence of increased density pattern and scar-like pattern had PE (p = 0.00038, 0.00044, respectively). Conclusion: Computed tomographic appearance after SBRT was classified into five patterns of acute radiation pneumonitis and three patterns of radiation fibrosis. Our results suggest that SBRT can be also safely performed even in patients with PE.

Kimura, Tomoki [Department of Radiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan) and Department of Radiology, Kagawa University, School of Medicine, Kagawa (Japan)]. E-mail: tkkimura@med.kawawa-u.ac.jp; Matsuura, Kanji [Department of Radiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Murakami, Yuji [Department of Radiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Hashimoto, Yasutoshi [Department of Radiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Kenjo, Masahiro [Department of Radiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Kaneyasu, Yuko [Department of Radiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Wadasaki, Koichi [Department of Radiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Hirokawa, Yutaka [Hiroshima Heiwa Clinic, Hiroshima (Japan); Ito, Katsuhide [Department of Radiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Okawa, Motoomi [Department of Radiology, Kagawa University, School of Medicine, Kagawa (Japan)

2006-10-01T23:59:59.000Z

346

Research Article Prevalence of Depression and Dementia among Adults with Developmental Disabilities in Manitoba, Canada  

E-Print Network (OSTI)

Copyright 2011 Shahin Shooshtari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Study Objective. To estimate and compare the prevalence of dementia and depression among adults with and without developmental disabilities (DDs). Methods. We linked data from several provincial administrative databases to identify persons with DDs. We matched cases with DD with persons without DD as to sex, age, and place of residence. We estimated the prevalence of dementia and depression and compared the two groups using the Generalized Estimating Equations (GEEs) technique. Results. The estimated prevalence of depression and dementia among younger adults (2054) and older adults (50+) with DD was significantly higher than the estimated rates for the matched non-DD group (Depression: younger adults: RR = 2.96 (95 % CI 2.59

Shahin Shooshtari; Patricia Joan Martens; Charles A. Burchill; Natalia Dik; Saba Naghipur

2011-01-01T23:59:59.000Z

347

A Low-Dose Ipsilateral Lung Restriction Improves 3-D Conformal Planning for Partial Breast Radiation Therapy  

Science Conference Proceedings (OSTI)

In trials of 3D conformal external beam partial breast radiotherapy (PBRT), the dosimetrist must balance the priorities of achieving high conformity to the target versus minimizing low-dose exposure to the normal structures. This study highlights the caveat that in the absence of a low-dose lung restriction, the use of relatively en-face fields may meet trial-defined requirements but expose the ipsilateral lung to unnecessary low-dose radiation. Adding a low-dose restriction that {dose resulted in successful plans in 88% of cases. This low-dose lung limit should be used in PBRT planning.

Mitchell, Tracy [Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, University of Victoria, Victoria, British Columbia (Canada); Truong, Pauline T., E-mail: ptruong@bccancer.bc.c [Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, University of Victoria, Victoria, British Columbia (Canada); Salter, Lee; Graham, Cathy; Gaffney, Helene; Beckham, Wayne; Olivotto, Ivo A. [Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, University of Victoria, Victoria, British Columbia (Canada)

2011-04-01T23:59:59.000Z

348

Combining Physical and Biologic Parameters to Predict Radiation-Induced Lung Toxicity in Patients With Non-Small-Cell Lung Cancer Treated With Definitive Radiation Therapy  

SciTech Connect

Purpose: To investigate the plasma dynamics of 5 proinflammatory/fibrogenic cytokines, including interleukin-1beta (IL-1{beta}), IL-6, IL-8, tumor necrosis factor alpha (TNF-{alpha}), and transforming growth factor beta1 (TGF-{beta}1) to ascertain their value in predicting radiation-induced lung toxicity (RILT), both individually and in combination with physical dosimetric parameters. Methods and Materials: Treatments of patients receiving definitive conventionally fractionated radiation therapy (RT) on clinical trial for inoperable stages I-III lung cancer were prospectively evaluated. Circulating cytokine levels were measured prior to and at weeks 2 and 4 during RT. The primary endpoint was symptomatic RILT, defined as grade 2 and higher radiation pneumonitis or symptomatic pulmonary fibrosis. Minimum follow-up was 18 months. Results: Of 58 eligible patients, 10 (17.2%) patients developed RILT. Lower pretreatment IL-8 levels were significantly correlated with development of RILT, while radiation-induced elevations of TGF-ss1 were weakly correlated with RILT. Significant correlations were not found for any of the remaining 3 cytokines or for any clinical or dosimetric parameters. Using receiver operator characteristic curves for predictive risk assessment modeling, we found both individual cytokines and dosimetric parameters were poor independent predictors of RILT. However, combining IL-8, TGF-ss1, and mean lung dose into a single model yielded an improved predictive ability (P<.001) compared to either variable alone. Conclusions: Combining inflammatory cytokines with physical dosimetric factors may provide a more accurate model for RILT prediction. Future study with a larger number of cases and events is needed to validate such findings.

Stenmark, Matthew H. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Cai Xuwei [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States) [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Radiation Oncology, Shanghai Cancer Hospital, Fudan University, Shanghai (China); Shedden, Kerby [Department of Biostatistics, University of Michigan Medical Center, Ann Arbor, Michigan (United States)] [Department of Biostatistics, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Hayman, James A. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Yuan Shuanghu [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States) [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Radiation Oncology, Shangdong Cancer Hospital, Jinan (China); Ritter, Timothy [Veterans Affairs Medical Center, Ann Arbor, Michigan (United States)] [Veterans Affairs Medical Center, Ann Arbor, Michigan (United States); Ten Haken, Randall K.; Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Kong Fengming, E-mail: fengkong@med.umich.edu [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Veterans Affairs Medical Center, Ann Arbor, Michigan (United States)

2012-10-01T23:59:59.000Z

349

The Impact of Economic Conditions on Participation in Disability Programs: Evidence from the Coal Boom and Bust. The American Economic Review 92(1  

E-Print Network (OSTI)

with much of the data on OASDIs disability program. Gerry Faulhaber, Matt Kahn, Janice Madden, Terra McKinnish, and seminar participants at the Regional Science Association International meetings, the

Dan Black; Kermit Daniel; Seth Sanders; We Thank Susan Black; Amitabh Ch; Noreen Connery; Leigh Ann Leshock; Philip Mcgivney; Victoria Moyer; Reginald Roberts; Suzanne Plourde

2002-01-01T23:59:59.000Z

350

Carotenoids & Retinoids; Molecular Aspects and Health IssuesChapter 10 Biological Activity of Lycopene Against Smoke-Induced Lung Lesions  

Science Conference Proceedings (OSTI)

Carotenoids & Retinoids; Molecular Aspects and Health Issues Chapter 10 Biological Activity of Lycopene Against Smoke-Induced Lung Lesions Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press ...

351

The Use of the Active Breathing Coordinator Throughout Radical Non-Small-Cell Lung Cancer (NSCLC) Radiotherapy  

SciTech Connect

Purpose: To assess feasibility and reproducibility of an Active Breathing Coordinator (ABC) used throughout radical radiotherapy for non-small-cell lung cancer, and compare lung dosimetric parameters between free-breathing and ABC plans. Methods and Materials: A total of 18 patients, recruited into an approved study, had free-breathing and ABC breath-hold treatment plans generated. Lung volume, the percentage volume of lung treated to a dose of {>=}20 Gy (V{sub 20}), and mean lung dose (MLD) were compared. Treatment (64 Gy in 32 fractions, 5 days/week) was delivered in breath-hold. Repeat breath-hold computed tomography scans were used to assess change in gross tumor volume (GTV) size and position. Setup error was also measured and potential GTV-planning target volume (PTV) margins calculated. Results: Seventeen of 18 patients completed radiotherapy using ABC daily. Intrafraction tumor position was consistent, but interfraction variation had mean (range) values of 5.1 (0-25), 3.6 (0-9.7), and 3.5 (0-16.6) mm in the superoinferior (SI), right-left (RL), and anteroposterior (AP) directions, respectively. Tumor moved partially outside the PTV in 5 patients. Mean reduction in GTV from planning to end of treatment was 25% (p = 0.003). Potentially required PTV margins were 18.1, 11.9, and 11.9 mm in SI, RL, and AP directions. ABC reduced V{sub 20} by 13% (p = 0.0001), V{sub 13} by 12% (p = 0.001), and MLD by 13% (p < 0.001) compared with free-breathing; lung volume increased by 41% (p < 0.001). Conclusions: Clinically significant movements of GTV were seen during radiotherapy for non-small-cell lung cancer using ABC. Image guidance is recommended with ABC. The use of ABC can reduce dose volume parameters determining lung toxicity, and might allow for equitoxic radiotherapy dose escalation.

Brock, Juliet, E-mail: juliet.brock@icr.ac.uk [Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Downs Road, Sutton, Surrey (United Kingdom); McNair, Helen A.; Panakis, Niki; Symonds-Tayler, Richard; Evans, Phil M.; Brada, Michael [Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Downs Road, Sutton, Surrey (United Kingdom)

2011-10-01T23:59:59.000Z

352

Early and continuing effects of combined alpha and beta irradiation of the lung:  

SciTech Connect

This report summarizes an inhalation exposure experiment that concerns early and continuing effects of combined alpha and beta irradiation of the lung of rats. Both morbidity at 18 months and mortality within 18 months after exposure were examined for rats exposed to the beta-emitter /sup 147/Pm, the alpha-emitter /sup 238/Pu, or both combined. The results were used to validate hazard-function models that were developed (1)for pulmonary functional morbidity at 18 months and (2) for lethality from radiation pneumonitis and pulmonary fibrosis within 18 months. Both models were found to adequately predict the experimental observations after combined chronic alpha and beta irradiation of the lung. A relative biological effectiveness of approximately 7 was obtained for /sup 238/Pu alpha radiation compared to /sup 147/Pm beta radiation for both pulmonary functional morbidity and lethality from radiation pneumonitis and pulmonary fibrosis. 12 refs., 16 figs., 11 tabs.

Scott, B.R.; Hahn, F.F.; Snipes, M.B.; Newton, G.J.; Eidson, A.F.; Mauderly, J.L.; Boecker, B.B.

1988-03-01T23:59:59.000Z

353

Morphometry for alpha particle hits of critical targets in the lungs. Final technical report  

SciTech Connect

The objective of this study is to provide detailed data on the number, location and type of critical target cells in the airspaces and to use these data in order to make risk assessments of the health effects of radon and radon progeny in the lungs. This will be done by quantitative morphometric study of the distribution of the various cell types and mucous lining layers in the lungs. The results provide anatomically correct models for dosimetry in the rate and human airways which significantly improve the ability to do risk assessment for radon exposures by providing quantitative data for specific cell types and provide a basis for mechanism based comparison between data available in animal exposures and human epidemiology.

Mercer, R.R.

1998-11-01T23:59:59.000Z

354

Building Public Trust: Part 3  

NLE Websites -- All DOE Office Websites (Extended Search)

3: Righting Past Wrongs 3: Righting Past Wrongs Overview The ACHRE report reviewed in detail several case studies of government- supported human radiation research including: the injections of plutonium into 18 hospital patients during and after World War II, research with prisoners, and research on patients who were exposed to total body irradiation in clinical settings. The Advisory Committee also considered issues related to certain radiation exposures associated with government activities that the Advisory Committee concluded should not be considered "human experiments." These exposures were sustained as a result of government activity undertaken for purposes other than human radiation research. The exposed populations include atomic veterans, uranium miners, and residents of the Marshall Islands exposed to fallout from U. S. weapons testing.

355

Building Public Trust: Appendix D  

NLE Websites -- All DOE Office Websites (Extended Search)

D D PROPOSED LEGISLATION TO AMEND THE RADIATION EXPOSURE AND COMPENSATION ACT A BILL To amend the eligibility criteria of the Radiation Exposure Compensation Act and for other purposes. Be it enacted by the Senate and House of Representatives of the United States of America in Congress assembled, SECTION 1. SHORT TITLE. This Act may be cited as the "The Radiation Exposure Compensation Act Amendments of 1997." SEC. 2. The Radiation Exposure Compensation Act, 42 U. S. C. § 2210 note (Supp. 1995), (referred to in this Act as "the Act"), is amended as follows: (a) CLAIMS RELATING TO ATMOSPHERIC NUCLEAR TESTING.;( 1) Section 4( a)( 1) of the Act is amended to read as follows: "( 1) Claims relating to childhood leukemia - Any indi-vidual

356

Building Public Trust: Part 2  

NLE Websites -- All DOE Office Websites (Extended Search)

2: Protecting Future Human Subjects 2: Protecting Future Human Subjects Overview The success of the effort to open the historical record will be measured, in part, by whether we avoid repeating the mistakes of the past. ACHRE's review of human radiation experiments raised questions of whether the current system of protection is adequate for all types of human subjects research. The measures described below will strengthen the protection of human subjects and address ACHRE's findings. The measures described below will strengthen the protection of human subjects and address ACHRE's findings. Federal responsibilities for maintaining ethics in human subjects research are dispersed in several agencies and committees in the government. First, each agency is responsible for the ethical admin-istration of its programs, including grants and contracts. Second, the President's Office of Science and Technology Policy has a statutory oversight role, and will continue to monitor and address issues of science and ethics. Third, the Department of Health and Human Services has a convening role among agencies that are bound by the Common Rule the Federal Policy for the Protection of Human Subjects which, along with Food and Drug Administration (FDA) regulations, governs all federally conducted, funded, or regulated research (56 Federal Register 28010, June 18, 1991). Finally, the National Bioethics Advisory Commission (NBAC) an independent body recently established by the President is taking up some of the most pressing ethical issues faced by this country.

357

Building Public Trust: Appendix A  

NLE Websites -- All DOE Office Websites (Extended Search)

A A REMARKS BY PRESIDENT WILLIAM J. CLINTON IN ACCEPTANCE OF HUMAN RADIATION FINAL REPORT October 3, 1995 Old Executive Office Building Let me begin with a simple thank you to everyone who participated in this extraordinary project and to everyone who supported them. I want to thank Secretary O'Leary for her extraordinary devotion to this cause. And you heard in her remarks basically the way that she views this. It's a part of her ongoing commitment to finish the end of the Cold War. And perhaps no Energy Secretary has ever done as much as she has to be an advocate, whether it is for continued reforms within the Energy Department or her outspoken endorsement of the strongest possible commitment on the part of the United States to a Comprehensive Test Ban Treaty, which I believe we will achieve next year in no small measure thanks to the support of the Secretary of Energy.

358

A Trusted Hybrid Software Radio  

frequencies and communications standards. It would be capable of global interoperability across a variety of frequencies and communications standards.

359

Building Public Trust: Appendix C  

NLE Websites -- All DOE Office Websites (Extended Search)

protection is required every 5 years, from all nine NASA Field Installations and the Jet Propulsion Laboratory, if the Center is conducting human subjects research. Centers not...

360

Building Public Trust: Part 1  

NLE Websites -- All DOE Office Websites (Extended Search)

1: Openness in Government Overview Throughout our nation's history, the government has needed to operate with some secrecy to protect our nation's security. At the same time,...

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
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361

Autonomic and trusted computing paradigms  

Science Conference Proceedings (OSTI)

The emerging autonomic computing technology has been hailed by world-wide researchers and professionals in academia and industry. Besides four key capabilities, well known as self-CHOP, we propose an additional self-regulating capability to explicitly ...

Xiaolin Li; Hui Kang; Patrick Harrington; Johnson Thomas

2006-09-01T23:59:59.000Z

362

Trusting the Cloud Christian Cachin  

E-Print Network (OSTI)

conditions is that they are not so intuitive to understand as atomicity, for example. Aiming to provide

363

Marketing Proposal UBC Properties Trust  

E-Print Network (OSTI)

would like to highlight several features such as Energy Star windows, energy efficient home appliances Water efficient appliances The cost of a conventional refrigerator is $ 1070. How much more are you willing to pay for an environmentally friendly appliance? Range Number of People Chose $ 0 ­ 10 0 $ 10

364

Trust During an Energy Crisis  

E-Print Network (OSTI)

Arctic National Wildlife Refuge (ANWR). We are not directlythe California shore and in ANWR. On the left half of thepercent oppose drilling in ANWR. 6 Feeling thermometers to

Smith, Eric R.A.N.; Carlisle, Juliet; Michaud, Kristy

2003-01-01T23:59:59.000Z

365

Deferring trust in fluid replication  

Science Conference Proceedings (OSTI)

Mobile nodes rely on external services to provide safety, sharing, and additional resources. Unfortunately, as mobile nodes move through the networking infrastructure, the costs of accessing servers change. Fluid replication allows mobile clients to ...

Brian D. Noble; Ben Fleis; Landon P. Cox

2000-09-01T23:59:59.000Z

366

Carbon Trust | Open Energy Information  

Open Energy Info (EERE)

company funded by the UK government to help business and the public sector cut carbon emissions and capture the commercial potential of low carbon technologies....

367

Incentive-based Cyber Trust  

Science Conference Proceedings (OSTI)

... to download Symantec Internet Threat Meter, based on ... computing capacity is based on virtual servers the ... 6, 2005, http://infosecon.net/workshop/pdf ...

2010-10-04T23:59:59.000Z

368

Advanced Credentialing for Trusted Networks  

among emergency responders, with others in the community, and with the outside world. ORNL researchers have developed a Web 2.0 credentialing system ...

369

Advanced Credentialing for Trusted Networks  

informationamong emergency responders, with others in the community, and with the outside world. ORNL researchers have developed a Web 2.0

370

Building Public Trust: Apendix B  

NLE Websites -- All DOE Office Websites (Extended Search)

B B ACCESS TO RECORDS AND INFORMATION RELATING TO HUMAN RADIATION EXPERIMENTS Advisory Committee on Human Radiation Experiments (ACHRE) Collection at the National Archives, College Park Overview: 665 cubic feet of records from the Advisory Committee on Human Radiation Experiments have been deposited at the National Archives and made part of Record Group 220, Presidential Committees, Commissions, and Boards. The collection can be accessed through the Archive's Textual Reference Branch located at Archives II, 8601 Adelphi Road, College Park, Maryland. The phone number is (301) 713- 7250. The collection consists primarily of documents collected from Federal agencies and other sources during the Committee's research process, but also includes the Committee's administrative files, meeting documentation, notes, and other records generated by the staff.

371

Centriacinar alterations in lungs of cats chronically exposed to diesel exhaust  

SciTech Connect

This study describes the morphologic changes in the centriacinar regions of lungs following long-term exposure of cats to diesel exhaust. Nine male cats (13 months of age) from a minimal disease colony were exposed to diesel exhaust for 8 hours/day, 7 days/week for 27 months. Eight cats were exposed to filtered air. Following exposure, the animals were killed by exsanguination and the lungs and trachea removed from the chest by thoracotomy, weighed, and fixed via tracheal cannula with glutaraldehyde/paraformaldehyde (550 mOsmoles, pH 7.4) at 30 cm of pressure. Centriacinar regions were selected from fixed tissue, the airways bisected, and complementary tissue halves processed by a large block method for high resolution light microscopy and for scanning electron microscopy. Compared with controls, diesel-exposed cats had lower fresh lung and kidney weights and lower fixed volumes of the right cranial lobe. The volume fractions of pulmonary parenchyma and nonparenchyma were unchanged. Epithelium of terminal and respiratory bronchioles in exposed cats consisted of three types of cells (ciliated, basal, and Clara cells), compared with only one type (Clara cells) in controls. Carbon-laden macrophages were found filling alveolar and interstitial spaces in exposed animals. Type 2 pneumocyte hyperplasia was present in proximal interalveolar septa. More distal alveolar ducts and the majority of the rest of the parenchyma were unchanged from controls. We concluded that exposure to diesel exhaust produces changes in both epithelial and interstitial tissue compartments and that the focus of these lesions in peripheral lung is the centriacinar region where alveolar ducts join terminal conducting airways.

Plopper, C.G.; Hyde, D.M.; Weir, A.J.

1983-10-01T23:59:59.000Z

372

Clinical and prognostic significance of lung thallium uptake on rest imaging in acute myocardial infarction  

Science Conference Proceedings (OSTI)

Exercise-induced pulmonary uptake of thallium-201 in patients with ischemic heart disease is probably due to transient pulmonary edema and left ventricular failure induced by exercise. The significance of increased lung uptake of thallium-201 at rest after acute myocardial infarction (AMI) has not been described. Ninety-six patients admitted with chest pain for suspected AMI or unstable angina underwent thallium-201 imaging at rest. Using conventional diagnostic criteria, 62 had AMI, 12 had unstable angina and 22 had neither. Increased lung uptake of thallium-201 was present in 24 of the total 96 (25%) patients, 20 of the 62 (32%) patients with AMI and 4 of 34 (13%) patients with no evidence of infarction. In the AMI group, those with increased lung thallium-201 uptake had a higher mean +/- standard deviation segmental thallium-201 defect score (22 +/- 7 vs 12 +/- 8, p less than 0.0001), lower ejection fraction (35 +/- 14 vs 49 +/- 14%, p less than 0.002), higher peak creatine kinase levels (2,410 +/- 1,247 vs 1,496 +/- 1,228 IU/liter, p less than 0.01), higher wall motion abnormality score (25 +/- 13 vs 13 +/- 12, p less than 0.0001), increased incidence of clinical in-hospital heart failure (15 of 20 vs 7 of 42, p less than 0.0001) and higher short-term mortality (4 of 20 vs 1 of 42, p less than 0.02) compared to those without increased lung thallium-201 uptake.

Jain, D.; Lahiri, A.; Raftery, E.B. (Northwick Park Hospital, Harrow, Middlesex (England))

1990-01-15T23:59:59.000Z

373

Predicting the Risk of Secondary Lung Malignancies Associated With Whole-Breast Radiation Therapy  

Science Conference Proceedings (OSTI)

Purpose: The risk of secondary lung malignancy (SLM) is a significant concern for women treated with whole-breast radiation therapy after breast-conserving surgery for early-stage breast cancer. In this study, a biologically based secondary malignancy model was used to quantify the risk of secondary lung malignancies (SLMs) associated with several common methods of delivering whole-breast radiation therapy (RT). Methods and Materials: Both supine and prone computed tomography simulations of 15 women with early breast cancer were used to generate standard fractionated and hypofractionated whole-breast RT treatment plans for each patient. Dose-volume histograms (DVHs) of the ipsilateral breast and lung were calculated for each patient on each plan. A model of spontaneous and radiation-induced carcinogenesis was used to determine the relative risks of SLMs for the different treatment techniques. Results: A higher risk of SLMs was predicted for supine breast irradiation when compared with prone breast irradiation for both the standard fractionation and hypofractionation schedules (relative risk [RR] = 2.59, 95% confidence interval (CI) = 2.30-2.88, and RR = 2.68, 95% CI = 2.39-2.98, respectively). No difference in risk of SLMs was noted between standard fractionation and hypofractionation schedules in either the supine position (RR = 1.05, 95% CI = 0.97-1.14) or the prone position (RR = 1.01, 95% CI = 0.88-1.15). Conclusions: Compared with supine whole-breast irradiation, prone breast irradiation is associated with a significantly lower predicted risk of secondary lung malignancy. In this modeling study, fractionation schedule did not have an impact on the risk of SLMs in women treated with whole-breast RT for early breast cancer.

Ng, John, E-mail: jon9024@nyp.org [Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Shuryak, Igor [Center for Radiological Research, Columbia University Medical Center, New York, NY (United States); Xu Yanguang; Clifford Chao, K.S. [Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Brenner, David J. [Center for Radiological Research, Columbia University Medical Center, New York, NY (United States); Burri, Ryan J. [Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States)

2012-07-15T23:59:59.000Z

374

Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med  

E-Print Network (OSTI)

A borderline viability model of bronchopulmonary dysplasia (BPD)/chronic lung disease of infancy (CLD) with pathophysiologic parameters consistent with those in extremely immature humans with BPD/CLD is described. After prenatal steroid treatment of pregnant dams, 12 premature baboons were delivered by cesarean-section at 125 d (term gestation, 185 d), treated with exogenous surfactant, and maintained on appropriate oxygen and positive pressure ventilation for at least 1 to 2 mo. In spite of appropriate oxygenation (median FI O2 at 28 d ? 0.32; range, 0.21 to 0.50) and ventilatory strategies to prevent volutrauma, the baboons exhibited pulmonary pathologic lesions known to occur in extremely immature humans of less than 1,000 g: alveolar hypoplasia, variable saccular wall fibrosis, and minimal, if any, airway disease. The CLD baboon lungs showed significantly decreased alveolization and internal surface area measurements when compared with term and term ? 2-mo air-breathing controls. A decrease in capillary vasculature was evident by PECAM staining, accompanied by dysmorphic changes. Significant elevations of TNF-?, IL-6, IL-8 levels, but not of IL-1 ? and IL-10, in tracheal aspirate fluids were present at various times during the period of ventilatory support, supporting a role for mediator-induced autoinflammation. IL-8 levels were elevated in necropsy lavages of animals with significant lung infection. This model demonstrates that impaired alveolization

Jacqueline J. Coalson; Vicki T. Winter; Theresa Siler-khodr; Bradley A. Yoder

1999-01-01T23:59:59.000Z

375

Incidence of non-lung solid cancers in Czech uranium miners: A case-cohort study  

Science Conference Proceedings (OSTI)

Objectives: Uranium miners are chronically exposed to radon and its progeny, which are known to cause lung cancer and may be associated with leukemia. This study was undertaken to evaluate risk of non-lung solid cancers among uranium miners in Pribram region, Czech Republic. Methods: A retrospective stratified case-cohort study in a cohort of 22,816 underground miners who were employed between 1949 and 1975. All incident non-lung solid cancers were ascertained among miners who worked underground for at least 12 months (n=1020). A subcohort of 1707 subjects was randomly drawn from the same population by random sampling stratified on age. The follow-up period lasted from 1977 to 1996. Results: Relative risks comparing 180 WLM (90th percentile) of cumulative lifetime radon exposure to 3 WLM (10th percentile) were 0.88 for all non-lung solid cancers combined (95% CI 0.73-1.04, n=1020), 0.87 for all digestive cancers (95% CI 0.69-1.09, n=561), 2.39 for gallbladder cancer (95% CI 0.52-10.98, n=13), 0.79 for larynx cancer (95% CI 0.38-1.64, n=62), 2.92 for malignant melanoma (95% CI 0.91-9.42, n=23), 0.84 for bladder cancer (95% CI 0.43-1.65, n=73), and 1.13 for kidney cancer (95% CI 0.62-2.04, n=66). No cancer type was significantly associated with radon exposure; only malignant melanoma and gallbladder cancer showed elevated but non-significant association with radon. Conclusions: Radon was not significantly associated with incidence of any cancer of interest, although a positive association of radon with malignant melanoma and gallbladder cancer cannot be entirely ruled out. - Research highlights: {yields} Uranium miners are chronically exposed to radon. {yields} We evaluate risk of non-lung solid cancers among uranium miners. {yields} No cancer type was significantly associated with radon exposure. {yields} Malignant melanoma and gallbladder cancer showed non-significant elevated risk.

Kulich, M., E-mail: kulich@karlin.mff.cuni.cz [Department of Statistics, Faculty of Mathematics and Physics, Charles University, Sokolovska 83, CZ-186 75 Praha 8 (Czech Republic); Rericha, V. [Regional Hospital Pribram (Czech Republic)] [Regional Hospital Pribram (Czech Republic); Rericha, R. [Center of Epidemiological Studies, Pribram (Czech Republic)] [Center of Epidemiological Studies, Pribram (Czech Republic); Shore, D.L. [Westat, Inc., Durham, NC (United States)] [Westat, Inc., Durham, NC (United States); Sandler, D.P. [Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC (United States)] [Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC (United States)

2011-04-15T23:59:59.000Z

376

Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the atomic bomb survivors study  

Science Conference Proceedings (OSTI)

Current lung cancer risk estimates after exposure to low-linear energy transfer radiation such as X rays are based on studies of people exposed to such radiation at high dose rates, for example the atomic bomb survivors. Radiobiology and animal experiments suggest that risks from exposure at low to moderate dose rates, for example medical diagnostic procedures, may be overestimated by such risk models, but data for humans to examine this issue are limited. In this paper we report on lung cancer mortality between 1950 and 1987 in a cohort of 64,172 Canadian tuberculosis patients, of whom 39% were exposed to highly fractionated multiple chest fluoroscopies leading to a mean lung radiation dose of 1.02 Sv received at moderate dose rates. These data have been used to estimate the excess relative risk per sievert of lung cancer mortality, and this is compared directly to estimates derived from 75,991 atomic bomb survivors. Based on 1,178 lung cancer deaths in the fluoroscopy study, there was no evidence of any positive association between risk and dose, with the relative risk at 1 Sv being 1.00 (95% confidence interval 0.94, 1.07), which contrasts with that based on the atomic bomb survivors, 1.60 (1.27, 1.99). The difference in effect between the two studies almost certainly did not arise by chance (P = 0.0001). This study provides strong support from data for humans for a substantial fractionation/dose-rate effect for low-linear energy transfer radiation and lung cancer risk. This implies that lung cancer risk from exposures to such radiation at present-day dose rates is likely to be lower than would be predicted by current radiation risk models based on studies of high-dose-rate exposures. 25 refs., 8 tabs.

Howe, G.R. [Univ. of Toronto, Ontario (Canada)

1995-06-01T23:59:59.000Z

377

Dosimetric impact of Acuros XB deterministic radiation transport algorithm for heterogeneous dose calculation in lung cancer  

SciTech Connect

Purpose: The novel deterministic radiation transport algorithm, Acuros XB (AXB), has shown great potential for accurate heterogeneous dose calculation. However, the clinical impact between AXB and other currently used algorithms still needs to be elucidated for translation between these algorithms. The purpose of this study was to investigate the impact of AXB for heterogeneous dose calculation in lung cancer for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT). Methods: The thorax phantom from the Radiological Physics Center (RPC) was used for this study. IMRT and VMAT plans were created for the phantom in the Eclipse 11.0 treatment planning system. Each plan was delivered to the phantom three times using a Varian Clinac iX linear accelerator to ensure reproducibility. Thermoluminescent dosimeters (TLDs) and Gafchromic EBT2 film were placed inside the phantom to measure delivered doses. The measurements were compared with dose calculations from AXB 11.0.21 and the anisotropic analytical algorithm (AAA) 11.0.21. Two dose reporting modes of AXB, dose-to-medium in medium (D{sub m,m}) and dose-to-water in medium (D{sub w,m}), were studied. Point doses, dose profiles, and gamma analysis were used to quantify the agreement between measurements and calculations from both AXB and AAA. The computation times for AAA and AXB were also evaluated. Results: For the RPC lung phantom, AAA and AXB dose predictions were found in good agreement to TLD and film measurements for both IMRT and VMAT plans. TLD dose predictions were within 0.4%-4.4% to AXB doses (both D{sub m,m} and D{sub w,m}); and within 2.5%-6.4% to AAA doses, respectively. For the film comparisons, the gamma indexes ({+-}3%/3 mm criteria) were 94%, 97%, and 98% for AAA, AXB{sub Dm,m}, and AXB{sub Dw,m}, respectively. The differences between AXB and AAA in dose-volume histogram mean doses were within 2% in the planning target volume, lung, heart, and within 5% in the spinal cord. However, differences up to 8% between AXB and AAA were found at lung/soft tissue interface regions for individual IMRT fields. AAA was found to be 5-6 times faster than AXB for IMRT, while AXB was 4-5 times faster than AAA for VMAT plan. Conclusions: AXB is satisfactorily accurate for the dose calculation in lung cancer for both IMRT and VMAT plans. The differences between AXB and AAA are generally small except in heterogeneous interface regions. AXB D{sub w,m} and D{sub m,m} calculations are similar inside the soft tissue and lung regions. AXB can benefit lung VMAT plans by both improving accuracy and reducing computation time.

Han Tao; Followill, David; Repchak, Roman; Molineu, Andrea; Howell, Rebecca; Salehpour, Mohammad [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Mikell, Justin [Department of Radiation Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States); Mourtada, Firas [Department of Radiation Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Department of Radiation Oncology, Christiana Care Health System, Newark, Delaware 19713 (United States)

2013-05-15T23:59:59.000Z

378

The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): A Completed Reference Database of Lung Nodules on CT Scans  

SciTech Connect

Purpose: The development of computer-aided diagnostic (CAD) methods for lung nodule detection, classification, and quantitative assessment can be facilitated through a well-characterized repository of computed tomography (CT) scans. The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI) completed such a database, establishing a publicly available reference for the medical imaging research community. Initiated by the National Cancer Institute (NCI), further advanced by the Foundation for the National Institutes of Health (FNIH), and accompanied by the Food and Drug Administration (FDA) through active participation, this public-private partnership demonstrates the success of a consortium founded on a consensus-based process. Methods: Seven academic centers and eight medical imaging companies collaborated to identify, address, and resolve challenging organizational, technical, and clinical issues to provide a solid foundation for a robust database. The LIDC/IDRI Database contains 1018 cases, each of which includes images from a clinical thoracic CT scan and an associated XML file that records the results of a two-phase image annotation process performed by four experienced thoracic radiologists. In the initial blinded-read phase, each radiologist independently reviewed each CT scan and marked lesions belonging to one of three categories (''nodule{>=}3 mm,''''nodule<3 mm,'' and ''non-nodule{>=}3 mm''). In the subsequent unblinded-read phase, each radiologist independently reviewed their own marks along with the anonymized marks of the three other radiologists to render a final opinion. The goal of this process was to identify as completely as possible all lung nodules in each CT scan without requiring forced consensus. Results: The Database contains 7371 lesions marked ''nodule'' by at least one radiologist. 2669 of these lesions were marked ''nodule{>=}3 mm'' by at least one radiologist, of which 928 (34.7%) received such marks from all four radiologists. These 2669 lesions include nodule outlines and subjective nodule characteristic ratings. Conclusions: The LIDC/IDRI Database is expected to provide an essential medical imaging research resource to spur CAD development, validation, and dissemination in clinical practice.

NONE

2011-02-15T23:59:59.000Z

379

A cross country study of the role of the three sectors on the acceptance and integration of people with intellectual and physical disabilities in Kenya and the United States of America.  

E-Print Network (OSTI)

??This study examines acceptance and integration of people with intellectual and physical disabilities in the United States and Kenya and the involvement of the three (more)

Nash, Whitney

380

The Effects of the Texas Statewide Youth Leadership Forum Summer Training Event on the Self-Advocacy Abilities of High School Students with Disabilities  

E-Print Network (OSTI)

Self-advocates and professionals in the field agree on the critical importance of providing self-advocacy and leadership training to youth with disabilities. Youth Leadership Forum (YLF) programs have been developed and implemented nationwide to provide a training venue for youth with disabilities to gain self-advocacy and leadership skills. The problem is the lack of empirical evidence validating the effectiveness of self-advocacy training provided through the YLF training format. The purpose of this study was to evaluate the effects of the Texas Statewide Youth Leadership Forum (TXYLF) summer training event on the self-advocacy abilities of high school students with disabilities, and to examine the interaction effect of disability type and gender on the improvement of self-advocacy abilities. To accomplish this purpose, a Non-Equivalent Groups Design (NEGD) was selected and used. The target population for this study was high school youth with disabilities in the state of Texas. The final sample included 68 youth. The TXYLF Pre/Post Questionnaire was the instrument used to measure the participants? self-advocacy abilities. The pretest was administered the week prior to the training event. The posttest was administered to the treatment group immediately following the training event and to the control group in the two weeks following the training event. Descriptive and inferential analyses were conducted to answer the primary and the exploratory questions. The inferential analyses included an ANCOVA and two factorial ANOVAS. Results indicated that the training had a positive effect on the selfadvocacy abilities of the participants. The results of the ANOVAs indicated (a) type of disability did not interact with treatment to affect the self-advocacy abilities of these participants, and (b) gender did not interact with treatment to affect the self-advocacy abilities of these participants. A descriptive and inferential post hoc examination of the treatment group data yielded an interaction by treatment effect for disability type indicating the treatment was more effective for participants with Developmental Disabilities. Future research studies should focus on replication of the current study results and examination of the long term effects of the self-advocacy training for youth with disabilities. In designing these studies, group designs should be considered and used.

Grenwelge, Cheryl Hamilton

2010-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Role played by Disabled-2 in albumin induced MAP Kinase signalling  

SciTech Connect

Albumin has been shown to activate the mitogen activated protein kinase (MAPK) pathway in proximal tubular cells (PTECs) of the kidney. Megalin, the putative receptor for albumin has potential signalling properties. However, the mechanisms by which megalin signals are unclear. The adaptor phosphoprotein Disabled-2 (Dab2) is known to interact with the cytoplasmic tail of megalin and may be involved in albumin-mediated MAPK signalling. In this study, we investigated the role of Dab2 in albumin-mediated MAPK signalling and further studied the role of Dab2 in albumin-induced TGF{beta}-1 secretion, a MAPK dependent event. We used RNA interference to knockdown Dab2 protein abundance in HKC-8 cells a model of human PTECs. Albumin activated ERK1,2 and Elk-1 in a MEK-1 dependent manner and resulted in secretion of TGF{beta}-1. In the absence of albumin, knockdown of Dab2 resulted in a trend towards increase in pERK1,2 consistent with its putative role as an inhibitor of cell proliferation. However albumin-induced ERK1,2 activation was completely abolished by Dab2 knockdown. Dab2 knockdown did not however result in inhibition of albumin-induced TGF{beta}-1 secretion. These results suggest that Dab2 is a ligand dependent bi-directional regulator of ERK1,2 activity by demonstrating that in addition to its more traditional role as an inhibitor of ERK1,2 it may also activate ERK1,2.

Diwakar, Ramaswamy [South West Thames Institute for Renal Research, St. Helier Hospital, Wrythe Lane, Carshalton, Surrey SM5 1AA (United Kingdom)], E-mail: ramaswamy.diwakar@gmail.com; Pearson, Alexander L.; Colville-Nash, Paul [South West Thames Institute for Renal Research, St. Helier Hospital, Wrythe Lane, Carshalton, Surrey SM5 1AA (United Kingdom); Baines, Deborah L. [Basic Medical Sciences, St. Georges University of London, Cranmer Terrace, Tooting, London (United Kingdom); Dockrell, Mark E.C. [South West Thames Institute for Renal Research, St. Helier Hospital, Wrythe Lane, Carshalton, Surrey SM5 1AA (United Kingdom)

2008-02-15T23:59:59.000Z

382

Proton Beam Therapy of Stage II and III Non-Small-Cell Lung Cancer  

Science Conference Proceedings (OSTI)

Purpose: The present retrospective study assessed the role of proton beam therapy (PBT) in the treatment of patients with Stage II or III non-small-cell lung cancer who were inoperable or ineligible for chemotherapy because of co-existing disease or refusal. Patients and Methods: Between November 2001 and July 2008, PBT was given to 35 patients (5 patients with Stage II, 12 with Stage IIIA, and 18 with Stage IIIB) whose median age was 70.3 years (range, 47.4-85.4). The median proton dose given was 78.3 Gy (range, 67.1-91.3) (relative biologic effectiveness). Results: Local progression-free survival for Stage II-III patients was 93.3% at 1 year and 65.9% at 2 years during a median observation period of 16.9 months. Four patients (11.4%) developed local recurrence, 13 (37.1%) developed regional recurrence, and 7 (20.0%) developed distant metastases. The progression-free survival rate for Stage II-III patients was 59.6% at 1 year and 29.2% at 2 years. The overall survival rate of Stage II-III patients was 81.8% at 1 year and 58.9% at 2 years. Grade 3 or greater toxicity was not observed. A total of 15 patients (42.9%) developed Grade 1 and 6 (17.1%) Grade 2 toxicity. Conclusion: PBT for Stage II-III non-small-cell lung cancer without chemotherapy resulted in good local control and low toxicity. PBT has a definite role in the treatment of patients with Stage II-III non-small-cell lung cancer who are unsuitable for surgery or chemotherapy.

Nakayama, Hidetsugu, E-mail: hnakayam@tokyo-med.ac.jp [Proton Medical Research Center, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki (Japan); Department of Radiation Oncology, Tokyo Medical University, Shinjuku, Tokyo (Japan); Satoh, Hiroaki [Department of Respiratory Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki (Japan); Sugahara, Shinji [Proton Medical Research Center, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki (Japan); Department of Radiation Oncology, Tokyo Medical University, Shinjuku, Tokyo (Japan); Kurishima, Koichi [Department of Respiratory Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki (Japan); Tsuboi, Koji; Sakurai, Hideyuki [Proton Medical Research Center, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki (Japan); Ishikawa, Shigemi [Department of Thoracic Surgery, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki (Japan); Tokuuye, Koichi [Proton Medical Research Center, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki (Japan); Department of Radiation Oncology, Tokyo Medical University, Shinjuku, Tokyo (Japan)

2011-11-15T23:59:59.000Z

383

Biological effects of raw and processed oil shale particles in the lungs of laboratory animals  

SciTech Connect

Environmental and occupational health concerns will have an effect on the developing oil shale technologies. The mining and crushing of large volumes of rock will be a characteristic of at least some of these technologies, and above ground disposal of processed shale will require adequate control measures. Exposure by inhalation to the dusts that may arise from shale oil technologies may present a hazard both in the work force and in the local population. Animal studies dealing with the effects of oil shale-related materials in the lung are in progress. Experiments involving Syrian hamsters exposed by inhalation and by intratracheal instillation are described.

Holland, L.M.; Smith, D.M.; Thomas, R.G.

1979-06-01T23:59:59.000Z

384

Failure of catalase to protect against aflatoxin B{sub 1}-induced mouse lung tumorigenicity  

SciTech Connect

The carcinogenic mycotoxin aflatoxin B{sub 1} (AFB{sub 1}) induces 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation in mouse lung, an effect that can be prevented by treatment with polyethylene glycol-conjugated catalase (PEG-CAT). G {yields} T transversion mutation in K-ras, an early event in AFB{sub 1}-induced mouse lung carcinogenesis, is thought to result from AFB{sub 1}-8,9-exo-epoxide binding to DNA to form AFB{sub 1}-N{sup 7}-guanine, but may also result from formation of 8-OHdG. Therefore, oxidative DNA damage may be important in AFB{sub 1} carcinogenicity. The objective of this study was to determine whether PEG-CAT would prevent AFB{sub 1} tumorigenicity. Mouse lung tumorigenesis was assessed following treatment of female A/J mice with 300 kU/kg PEG-CAT ip and/or 50 mg/kg AFB{sub 1}. Mice were killed 7 months post-treatment and tumors greater than 1 mm in diameter were excised. Unexpectedly, the mean number of tumors per mouse in the PEG-CAT + AFB{sub 1} group (8.81 {+-} 3.64, n = 47) was greater than that of the group treated with AFB{sub 1} alone (7.05 {+-} 3.45, n = 42) (P < 0.05). The tumors obtained from mice treated with PEG-CAT + AFB{sub 1} were larger than those from mice treated with AFB{sub 1} alone (P < 0.05). There was no difference in K-ras exon 1 mutation spectrum or in the histological diagnosis of tumors between AFB{sub 1} and PEG-CAT + AFB{sub 1} groups (P > 0.05). In vitro incubation with mouse liver catalase (CAT) resulted in conversion of [{sup 3}H]AFB{sub 1} into a DNA-binding species, a possible explanation for the results observed in vivo. These results demonstrate that PEG-CAT is not protective against AFB{sub 1} carcinogenicity in mouse lung despite preventing DNA oxidation.

Guindon, Katherine A. [Department of Pharmacology and Toxicology, Queen' s University, Kingston, Ontario, K7L 3N6 (Canada); Foley, Julie F.; Maronpot, Robert R. [National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 (United States); Massey, Thomas E. [Department of Pharmacology and Toxicology, Queen' s University, Kingston, Ontario, K7L 3N6 (Canada)], E-mail: masseyt@queensu.ca

2008-03-01T23:59:59.000Z

385

Dosimetric effect of intrafraction tumor motion in phase gated lung stereotactic body radiotherapy  

Science Conference Proceedings (OSTI)

Purpose: A major concern for lung intensity modulated radiation therapy delivery is the deviation of actually delivered dose distribution from the planned one due to simultaneous movements of multileaf collimator (MLC) leaves and tumor. For gated lung stereotactic body radiotherapy treatment (SBRT), the situation becomes even more complicated because of SBRT's characteristics such as fewer fractions, smaller target volume, higher dose rate, and extended fractional treatment time. The purpose of this work is to investigate the dosimetric effect of intrafraction tumor motion during gated lung SBRT delivery by reconstructing the delivered dose distribution with real-time tumor motion considered. Methods: The tumor motion data were retrieved from six lung patients. Each of them received three fractions of stereotactic radiotherapy treatments with Cyberknife Synchrony (Accuray, Sunnyvale, CA). Phase gating through an external surrogate was simulated with a gating window of 5 mm. The resulting residual tumor motion curves during gating (beam-on) were retrieved. Planning target volume (PTV) was defined as physician-contoured clinical target volume (CTV) surrounded by an isotropic 5 mm margin. Each patient was prescribed with 60 Gy/3 fractions. The authors developed an algorithm to reconstruct the delivered dose with tumor motion. The DMLC segments, mainly leaf position and segment weighting factor, were recalculated according to the probability density function of tumor motion curve. The new DMLC sequence file was imported back to treatment planning system to reconstruct the dose distribution. Results: Half of the patients in the study group experienced PTV D95% deviation up to 26% for fractional dose and 14% for total dose. CTV mean dose dropped by 1% with tumor motion. Although CTV is almost covered by prescribed dose with 5 mm margin, qualitative comparison on the dose distributions reveals that CTV is on the verge of underdose. The discrepancy happens due to tumor excursion outside of the gating window, which, for our study group, is mainly caused by baseline shift, i.e., the change in general trend of the motion curve during extended period of treatment time. Conclusions: The dose deviation in PTV and CTV due to target motion is not always negligible in gated SBRT. Although CTVs are covered sufficiently with prescribed dose in most cases, some are on the verge of underdose due to large tumor excursion caused by factors such as baseline shift.

Zhao Bo; Yang Yong; Li Tianfang; Li Xiang; Heron, Dwight E.; Huq, M. Saiful [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232 (United States) and Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas 75390 (United States); Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232 (United States)

2012-11-15T23:59:59.000Z

386

A computerized scheme for lung nodule detection in multiprojection chest radiography  

SciTech Connect

Purpose: Our previous study indicated that multiprojection chest radiography could significantly improve radiologists' performance for lung nodule detection in clinical practice. In this study, the authors further verify that multiprojection chest radiography can greatly improve the performance of a computer-aided diagnostic (CAD) scheme. Methods: Our database consisted of 59 subjects, including 43 subjects with 45 nodules and 16 subjects without nodules. The 45 nodules included 7 real and 38 simulated ones. The authors developed a conventional CAD scheme and a new fusion CAD scheme to detect lung nodules. The conventional CAD scheme consisted of four steps for (1) identification of initial nodule candidates inside lungs, (2) nodule candidate segmentation based on dynamic programming, (3) extraction of 33 features from nodule candidates, and (4) false positive reduction using a piecewise linear classifier. The conventional CAD scheme processed each of the three projection images of a subject independently and discarded the correlation information between the three images. The fusion CAD scheme included the four steps in the conventional CAD scheme and two additional steps for (5) registration of all candidates in the three images of a subject, and (6) integration of correlation information between the registered candidates in the three images. The integration step retained all candidates detected at least twice in the three images of a subject and removed those detected only once in the three images as false positives. A leave-one-subject-out testing method was used for evaluation of the performance levels of the two CAD schemes. Results: At the sensitivities of 70%, 65%, and 60%, our conventional CAD scheme reported 14.7, 11.3, and 8.6 false positives per image, respectively, whereas our fusion CAD scheme reported 3.9, 1.9, and 1.2 false positives per image, and 5.5, 2.8, and 1.7 false positives per patient, respectively. The low performance of the conventional CAD scheme may be attributed to the high noise level in chest radiography, and the small size and low contrast of most nodules. Conclusions: This study indicated that the fusion of correlation information in multiprojection chest radiography can markedly improve the performance of CAD scheme for lung nodule detection.

Guo Wei; Li Qiang; Boyce, Sarah J.; McAdams, H. Page; Shiraishi, Junji; Doi, Kunio; Samei, Ehsan [Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 and College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110004 (China); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 and Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Faculty of Life Sciences, Kumamoto University, 4-24-1 Kuhonji, Kumamoto 962-0976 (Japan); Kurt Rossmann Laboratories for Radiologic Image Research, Department of Radiology, University of Chicago, Chicago, Illinois 60637 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 and Departments of Physics, Biomedical Engineering, Electrical and Computer Engineering, and Medical Physics, Duke University, Durham, North Carolina 27705 (United States)

2012-04-15T23:59:59.000Z

387

Functional Image-Guided Radiotherapy Planning in Respiratory-Gated Intensity-Modulated Radiotherapy for Lung Cancer Patients With Chronic Obstructive Pulmonary Disease  

SciTech Connect

Purpose: To investigate the incorporation of functional lung image-derived low attenuation area (LAA) based on four-dimensional computed tomography (4D-CT) into respiratory-gated intensity-modulated radiotherapy (IMRT) or volumetric modulated arc therapy (VMAT) in treatment planning for lung cancer patients with chronic obstructive pulmonary disease (COPD). Methods and Materials: Eight lung cancer patients with COPD were the subjects of this study. LAA was generated from 4D-CT data sets according to CT values of less than than -860 Hounsfield units (HU) as a threshold. The functional lung image was defined as the area where LAA was excluded from the image of the total lung. Two respiratory-gated radiotherapy plans (70 Gy/35 fractions) were designed and compared in each patient as follows: Plan A was an anatomical IMRT or VMAT plan based on the total lung; Plan F was a functional IMRT or VMAT plan based on the functional lung. Dosimetric parameters (percentage of total lung volume irradiated with {>=}20 Gy [V20], and mean dose of total lung [MLD]) of the two plans were compared. Results: V20 was lower in Plan F than in Plan A (mean 1.5%, p = 0.025 in IMRT, mean 1.6%, p = 0.044 in VMAT) achieved by a reduction in MLD (mean 0.23 Gy, p = 0.083 in IMRT, mean 0.5 Gy, p = 0.042 in VMAT). No differences were noted in target volume coverage and organ-at-risk doses. Conclusions: Functional IGRT planning based on LAA in respiratory-guided IMRT or VMAT appears to be effective in preserving a functional lung in lung cancer patients with COPD.

Kimura, Tomoki, E-mail: tkkimura@hiroshima-u.ac.jp [Department of Radiation Oncology, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima City (Japan); Nishibuchi, Ikuno; Murakami, Yuji; Kenjo, Masahiro; Kaneyasu, Yuko; Nagata, Yasushi [Department of Radiation Oncology, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima City (Japan)

2012-03-15T23:59:59.000Z

388

Dosimetric verification of the anisotropic analytical algorithm in lung equivalent heterogeneities with and without bone equivalent heterogeneities  

SciTech Connect

Purpose: In this study, the authors evaluated the accuracy of dose calculations performed by the convolution/superposition based anisotropic analytical algorithm (AAA) in lung equivalent heterogeneities with and without bone equivalent heterogeneities. Methods: Calculations of PDDs using the AAA and Monte Carlo simulations (MCNP4C) were compared to ionization chamber measurements with a heterogeneous phantom consisting of lung equivalent and bone equivalent materials. Both 6 and 10 MV photon beams of 4x4 and 10x10 cm{sup 2} field sizes were used for the simulations. Furthermore, changes of energy spectrum with depth for the heterogeneous phantom using MCNP were calculated. Results: The ionization chamber measurements and MCNP calculations in a lung equivalent phantom were in good agreement, having an average deviation of only 0.64{+-}0.45%. For both 6 and 10 MV beams, the average deviation was less than 2% for the 4x4 and 10x10 cm{sup 2} fields in the water-lung equivalent phantom and the 4x4 cm{sup 2} field in the water-lung-bone equivalent phantom. Maximum deviations for the 10x10 cm{sup 2} field in the lung equivalent phantom before and after the bone slab were 5.0% and 4.1%, respectively. The Monte Carlo simulation demonstrated an increase of the low-energy photon component in these regions, more for the 10x10 cm{sup 2} field compared to the 4x4 cm{sup 2} field. Conclusions: The low-energy photon by Monte Carlo simulation component increases sharply in larger fields when there is a significant presence of bone equivalent heterogeneities. This leads to great changes in the build-up and build-down at the interfaces of different density materials. The AAA calculation modeling of the effect is not deemed to be sufficiently accurate.

Ono, Kaoru; Endo, Satoru; Tanaka, Kenichi; Hoshi, Masaharu; Hirokawa, Yutaka [Department of Radiation Physics, Hiroshima Heiwa Clinic, 1-31 Kawaramachi, Naka-ku, Hiroshima 730-0856 (Japan); Quantum Energy Applications, Graduate School of Engineering, Hiroshima University, 4-1 Kagamiyama, Higashi-Hiroshima 730-8527 (Japan); Center of Medical Education, Sapporo Medical University, 17 Minami 1 Jo, Chuo-ku, Sapporo 060-8556 (Japan); Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553 (Japan); Department of Radiation Oncology, Hiroshima Heiwa Clinic, 1-31 Kawaramachi, Naka-ku, Hiroshima 730-0856 (Japan)

2010-08-15T23:59:59.000Z

389

Individualized Margins in 3D Conformal Radiotherapy Planning for Lung Cancer: Analysis of Physiological Movements and Their Dosimetric Impacts  

SciTech Connect

In conformal radiotherapy planning for lung cancer, respiratory movements are not taken into account when a single computed tomography (CT) scan is performed. This study examines tumor movements to design individualized margins to account for these movements and evaluates their dosimetric impacts on planning volume. Fifteen patients undergoing CT-based planning for radical radiotherapy for localized lung cancer formed the study cohort. A reference plan was constructed based on reference gross, clinical, and planning target volumes (rGTV, rCTV, and rPTV, respectively). The reference plans were compared with individualized plans using individualized margins obtained by using 5 serial CT scans to generate individualized target volumes (iGTV, iCTV, and iPTV). Three-dimensional conformal radiation therapy was used for plan generation using 6- and 23-MV photon beams. Ten plans for each patient were generated and dose-volume histograms (DVHs) were calculated. Comparisons of volumetric and dosimetric parameters were performed using paired Student t-tests. Relative to the rGTV, the total volume occupied by the superimposed GTVs increased progressively with each additional CT scans. With the use of all 5 scans, the average increase in GTV was 52.1%. For the plans with closest dosimetric coverage, target volume was smaller (iPTV/rPTV ratio 0.808) but lung irradiation was only slightly decreased. Reduction in the proportion of lung tissue that received 20 Gy or more outside the PTV (V20) was observed both for 6-MV plans (-0.73%) and 23-MV plans (-0.65%), with p = 0.02 and p = 0.04, respectively. In conformal RT planning for the treatment of lung cancer, the use of serial CT scans to evaluate respiratory motion and to generate individualized margins to account for these motions produced only a limited lung sparing advantage.

Germain, Francois [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Laval University, Quebec (Canada)], E-mail: fgermain@bccancer.bc.ca; Beaulieu, Luc; Fortin, Andre [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Laval University, Quebec (Canada)

2008-04-01T23:59:59.000Z

390

Dosimetric comparison of treatment plans based on free breathing, maximum, and average intensity projection CTs for lung cancer SBRT  

SciTech Connect

Purpose: To determine whether there is a CT dataset may be more favorable for planning and dose calculation by comparing dosimetric characteristics between treatment plans calculated using free breathing (FB), maximum and average intensity projection (MIP and AIP, respectively) CTs for lung cancer patients receiving stereotactic body radiation therapy (SBRT). Methods: Twenty lung cancer SBRT patients, treated on a linac with 2.5 mm width multileaf-collimator (MLC), were analyzed retrospectively. Both FB helical and four-dimensional CT scans were acquired for each patient. Internal target volume (ITV) was delineated based on MIP CTs and modified based on both ten-phase datasets and FB CTs. Planning target volume (PTV) was then determined by adding additional setup margin to ITV. The PTVs and beams in the optimized treatment plan based on FB CTs were copied to MIP and AIP CTs, with the same isocenters, MLC patterns and monitor units. Mean effective depth (MED) of beams, and some dosimetric parameters for both PTVs and most important organ at risk (OAR), lung minus PTV, were compared between any two datasets using two-tail paired t test. Results: The MEDs in FB and AIP plans were similar but significantly smaller (Ps < 0.001) than that in MIP plans. Minimum dose, mean dose, dose covering at least 90% and 95% of PTVs in MIP plans were slightly higher than two other plans (Ps < 0.008). The absolute volume of lung minus PTV receiving greater than 5, 10, and 20 Gy in MIP plans were significantly smaller than those in both FB and AIP plans (Ps < 0.008). Conformity index for FB plans showed a small but statistically significantly higher. Conclusions: Dosimetric characteristics of AIP plans are similar to those of FB plans. Slightly better target volume coverage and significantly lower low-dose region ({<=}30 Gy) in lung was observed in MIP plans. The decrease in low-dose region in lung was mainly caused by the change of lung volume contoured on two datasets rather than the differences of dose distribution between AIP and MIP plans. Compare with AIP datasets, FB datasets were more prone to significant image artifacts and MIP datasets may overestimate or underestimate the target volume when the target is closer to the denser tissue, so AIP seems favorable for planning and dose calculation for lung SBRT.

Tian Yuan; Wang Zhiheng; Ge Hong; Zhang Tian; Cai Jing; Kelsey, Christopher; Yoo, David; Yin Fangfang [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States) and Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science, Beijing 100021 (China); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 and Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou, Henan 450008 (China); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States)

2012-05-15T23:59:59.000Z

391

Patterns of Care for Lung Cancer in Radiation Oncology Departments of Turkey  

SciTech Connect

Purpose: To determine the patterns of care for lung cancer in Turkish radiation oncology centers. Methods and Materials: Questionnaire forms from 21 of 24 (87.5%) centers that responded were evaluated. Results: The most frequent histology was non-small cell lung cancer (NSCLC) (81%). The most common postoperative radiotherapy (RT) indications were close/(+) surgical margins (95%) and presence of pN2 disease (91%). The most common indications for postoperative chemotherapy (CHT) were '{>=} IB' disease (19%) and the presence of pN2 disease (19%). In Stage IIIA potentially resectable NSCLC, the most frequent treatment approach was neoadjuvant concomitant chemoradiotherapy (CHRT) (57%). In Stage IIIA unresectable and Stage IIIB disease, the most frequent approach was definitive concomitant CHRT (91%). In limited SCLC, the most common treatment approach was concomitant CHRT with cisplatin+etoposide for cycles 1-3, completion of CHT to cycles 4-6, and finally prophylactic cranial irradiation in patients with complete response (71%). Six cycles of cisplatin + etoposide CHT and palliative thoracic RT, when required, was the most commonly used treatment (81%) in extensive SCLC. Sixty-two percent of centers did not have endobronchial brachytherapy (EBB) facilities. Conclusion: There is great variation in diagnostic testing, treatment strategies, indications for postoperative RT and CHT, RT features, and EBB availability for LC cases. To establish standards, national guidelines should be prepared using a multidisciplinary approach.

Demiral, Ayse Nur [Dokuz Eylul University Medical School, Department of Radiation Oncology, Izmir (Turkey)], E-mail: ayse.demiral@deu.edu.tr; Alicikus, Zuemre Arican [Dokuz Eylul University Medical School, Department of Radiation Oncology, Izmir (Turkey); Isil Ugur, Vahide [Ankara Oncology Hospital, Department of Radiation Oncology, Ankara (Turkey); Karadogan, Ilker [Izmir Private Oncology Center, Izmir (Turkey); Yoeney, Adnan [Okmeydani Training and Research Hospital, Department of Radiation Oncology, Istanbul (Turkey); Andrieu, Meltem Nalca [Ankara University Medical School, Department of Radiation Oncology, Ankara (Turkey); Yalman, Deniz [Ege University Medical School, Department of Radiation Oncology, Izmir (Turkey); Pak, Yuecel [Gazi University Medical School, Department of Radiation Oncology, Ankara (Turkey); Aksu, Gamze [Akdeniz University Medical School, Department of Radiation Oncology, Antalya (Turkey); Ozyigit, Goekhan [Hacettepe University Medical School, Department of Radiation Oncology, Ankara (Turkey); Ozkan, Luetfi [Uludag University Medical School, Department of Radiation Oncology, Bursa (Turkey); Kilciksiz, Sevil [Gaziantep University Medical School, Department of Radiation Oncology, Gaziantep (Turkey); Koca, Sedat [Istanbul University Cerrahpasa Medical School, Department of Radiation Oncology, Istanbul (Turkey); Caloglu, Murat [Trakya University Medical School, Department of Radiation Oncology, Edirne (Turkey); Yavuz, Ali Aydin [Baskent University Medical School, Department of Radiation Oncology, Adana (Turkey); Basak Caglar, Hale [Marmara University Medical School, Department of Radiation Oncology, Istanbul (Turkey); Beyzadeoglu, Murat [Guelhane Military Medical Academy, Department of Radiation Oncology, Ankara (Turkey); Igdem, Sefik [Metropolitan Florence Nightingale Hospital, Department of Radiation Oncology, Istanbul (Turkey)] (and others)

2008-12-01T23:59:59.000Z

392

Fast Arc Delivery for Stereotactic Body Radiotherapy of Vertebral and Lung Tumors  

SciTech Connect

Purpose: Flattening filter-free (FFF) beams with higher dose rates and faster delivery are now clinically available. The purpose of this planning study was to compare optimized non-FFF and FFF RapidArc plans for stereotactic body radiotherapy (SBRT) and to validate the accuracy of fast arc delivery. Methods and Material: Ten patients with peripheral lung tumors and 10 with vertebral metastases were planned using RapidArc with a flattened 6-MV photon beam and a 10-MV FFF beam for fraction doses of 7.5-18 Gy. Dosimetry of the target and organs at risk (OAR), number of monitor units (MU), and beam delivery times were assessed. GafChromic EBT2 film measurements of FFF plans were performed to compare calculated and delivered dose distributions. Results: No major dosimetric differences were seen between the two delivery techniques. For lung SBRT plans, conformity indices and OAR doses were similar, although the average MU required were higher with FFF plans. For vertebral SBRT, FFF plans provided comparable PTV coverage, with no significant differences in OAR doses. Average beam delivery times were reduced by a factor of up to 2.5, with all FFF fractions deliverable within 4 min. Measured FFF plans showed high agreement with calculated plans, with more than 99% of the area within the region of interest fulfilling the acceptance criterion. Conclusion: The higher dose rate of FFF RapidArc reduces delivery times significantly, without compromising plan quality or accuracy of dose delivery.

Ong, Chin Loon, E-mail: c.ong@vumc.nl [Department of Radiation Oncology, VU University Medical Center, Amsterdam (Netherlands); Verbakel, Wilko F.A.R.; Dahele, Max; Cuijpers, Johan P.; Slotman, Ben J.; Senan, Suresh [Department of Radiation Oncology, VU University Medical Center, Amsterdam (Netherlands)

2012-05-01T23:59:59.000Z

393

Dose Constraints to Prevent Radiation-Induced Brachial Plexopathy in Patients Treated for Lung Cancer  

Science Conference Proceedings (OSTI)

Purpose: As the recommended radiation dose for non-small-cell lung cancer (NSCLC) increases, meeting dose constraints for critical structures like the brachial plexus becomes increasingly challenging, particularly for tumors in the superior sulcus. In this retrospective analysis, we compared dose-volume histogram information with the incidence of plexopathy to establish the maximum dose tolerated by the brachial plexus. Methods and Materials: We identified 90 patients with NSCLC treated with definitive chemoradiation from March 2007 through September 2010, who had received >55 Gy to the brachial plexus. We used a multiatlas segmentation method combined with deformable image registration to delineate the brachial plexus on the original planning CT scans and scored plexopathy according to Common Terminology Criteria for Adverse Events version 4.03. Results: Median radiation dose to the brachial plexus was 70 Gy (range, 56-87.5 Gy; 1.5-2.5 Gy/fraction). At a median follow-up time of 14.0 months, 14 patients (16%) had brachial plexopathy (8 patients [9%] had Grade 1, and 6 patients [7%] had Grade {>=}2); median time to symptom onset was 6.5 months (range, 1.4-37.4 months). On multivariate analysis, receipt of a median brachial plexus dose of >69 Gy (odds ratio [OR] 10.091; 95% confidence interval [CI], 1.512-67.331; p = 0.005), a maximum dose of >75 Gy to 2 cm{sup 3} of the brachial plexus (OR, 4.909; 95% CI, 0.966-24.952; p = 0.038), and the presence of plexopathy before irradiation (OR, 4.722; 95% CI, 1.267-17.606; p = 0.021) were independent predictors of brachial plexopathy. Conclusions: For lung cancers near the apical region, brachial plexopathy is a major concern for high-dose radiation therapy. We developed a computer-assisted image segmentation method that allows us to rapidly and consistently contour the brachial plexus and establish the dose limits to minimize the risk of brachial plexopathy. Our results could be used as a guideline in future prospective trials with high-dose radiation therapy for unresectable lung cancer.

Amini, Arya [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); University of California Irvine School of Medicine, Irvine, California (United States); Yang Jinzhong; Williamson, Ryan [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); McBurney, Michelle L. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Erasmus, Jeremy [Department of Diagnostic Imaging, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Allen, Pamela K.; Karhade, Mandar; Komaki, Ritsuko; Liao, Zhongxing; Gomez, Daniel; Cox, James [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Dong, Lei [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Welsh, James, E-mail: jwelsh@mdanderson.org [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

2012-03-01T23:59:59.000Z

394

Biodistribution of radioactive Cd125mTe/ZnS nanoparticles targeted with antibody to murine lung endothelium.  

Science Conference Proceedings (OSTI)

Radioactive cadmium telluride/zinc sulfide (Cd{sup 125m}Te/ZnS) nanoparticles were targeted to mouse lung with antibody to mouse lung endothelium and quantified using radiological histology in order to test the in vivo targeting efficacy of a nanoparticle-antibody (NP-mAb) system. The nanoparticles were linked to either a monoclonal antibody to mouse lung thrombomodulin (mAb 201B) or a control antibody (mAb 33), and injected into groups of 6-week-old Balb/C female mice. Animals were sacrificed at 1, 4, 24, 72 and 144 h post-injection, and biodistribution in major organs was determined. Full body microSPECT/CT imaging was performed on a pair of mice (experimental and control) providing visual confirmation of the biodistribution. The Cd{sup 125m}Te/ZnS NPs conjugated to mAb 201B principally target the lungs while the nanoparticles coupled to mAb 33 accumulate in the liver and spleen. These data provide, for the first time, a quantitative measurement of the in vivo targeting efficacy of an inorganic nanoparticle-mAb system.

Woodward, Jonathan [ORNL; Kennel, Steve J [ORNL; Mirzadeh, Saed [ORNL; Dai, Sheng [ORNL; Rondinone, Adam Justin [ORNL

2007-01-01T23:59:59.000Z

395

Detecting Radiation-Induced Injury Using Rapid 3D Variogram Analysis of CT Images of Rat Lungs  

SciTech Connect

A new heterogeneity analysis approach to discern radiation-induced lung damage was tested on CT images of irradiated rats. The method, combining octree decomposition with variogram analysis, demonstrated a significant correlation with radiation exposure levels, whereas conventional measurements and pulmonary function tests did not. The results suggest the new approach may be highly sensitive for assessing even subtle radiation-induced changes

Jacob, Rick E.; Murphy, Mark K.; Creim, Jeffrey A.; Carson, James P.

2013-10-01T23:59:59.000Z

396

Meta-analysis of Video Based Modeling Interventions for Individuals with Disabilities: Procedure, Participant, and Skill Specificity  

E-Print Network (OSTI)

The purpose of the present research was to address gaps in the video based modeling (VBM) literature through the use of meta-analytic techniques to provide clarity and specificity regarding the practical utility of VBM for participants with disabilities. Two meta-analyses of published single-case VBM research were conducted. Improvement rate difference, an effect size measure, was utilized to analyze the fifty-six single-case studies. The purpose of study one was to determine if differential effects occurred based on the type of model utilized and variations in procedural implementation. In addition, the quality of research was evaluated. The purpose of study two was to determine if participant characteristics, intervention components by participant characteristics, and targeted outcome moderated the effectiveness of video modeling with other as model (VMO). Results of Study One indicated moderate to strong effects for both VMO and video self-modeling, however, when further disaggregated based on type of model utilized, VMO with adult as model demonstrated statistically significant superiority in terms of outcome effects. Results also indicated VBM with reinforcement demonstrated greater effects than when delivered alone or as part of a package. Additionally, the evaluation of quality of research indicated a tendency of the previously published VBM research not to evaluate treatment integrity. Study Two found that age and diagnosis moderate the effectiveness of VMO, although strong effects were found across levels for both moderators. VMO was found to be more effective for elementary age participants and participants with autism spectrum disorders. Additionally, VMO with reinforcement demonstrated statistically significant stronger effects for participants with ASD than when it is delivered alone or as part of a package. However, VMO delivered as part of a package was more potent for participants with developmental disabilities. Considering targeted outcomes, the results indicated strong effects across skill areas, however, VMO was found to be most impactful when utilized to improve play skills versus other measured skills. Implications related to the practical application of VBM for individuals with disabilities particularly in regards to treatment decision making were discussed. Additionally, implications for future research were addressed.

Mason, Rose

2012-05-01T23:59:59.000Z

397

A Virus That Can Infect Lung Cancer Cells | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Imaging Plant Viruses Could Yield New Ways to Safeguard Crops Imaging Plant Viruses Could Yield New Ways to Safeguard Crops Extreme Pressure Reveals a Volume Expansion Phenomenon A Nuclear Receptor with Implications for a Host of Diseases Unexpected Materials in Earth's Lowermost Mantle Nailing Down the Exciton in LiF Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Virus That Can Infect Lung Cancer Cells OCTOBER 21, 2008 Bookmark and Share The 3-D structure of Seneca Valley Virus-001. (Courtesy: The Scripps Research Institute) The structure of the Senecavirus is also depicted at http://viperdb.scripps.edu/, the "Virus Particle Explorer" developed at Scripps Research by Reddy and his colleagues. The online database is a

398

The Association of Inbreeding With Lung Fibrosis Incidence in Beagle Dogs That Inhaled 238PuO2 or 239PuO2.  

Science Conference Proceedings (OSTI)

Studies of health effects in animals after exposure to internally deposited radionuclides were intended to supplement observational studies in humans. Both nuclear workers and Beagle dogs have exhibited plutonium associated lung fibrosis; however, the dogs smaller gene pool may limit the applicability of findings to humans. Data on Beagles that inhaled either plutonium-238 dioxide (238PuO2) or plutonium-239 dioxide (239PuO2) were analyzed. Wright's Coefficient of Inbreeding was used to measure genetic or familial susceptibility and was assessed as an explanatory variable when modeling the association between lung fibrosis incidence and plutonium exposure. Lung fibrosis was diagnosed in approximately 80% of the exposed dogs compared with 23.7% of the control dogs. The maximum degree of inbreeding was 9.4%. Regardless of isotope, the addition of inbreeding significantly improved the model in female dogs but not in males. In female dogs an increased inbreeding coefficient predicted decreased hazard of a lung fibrosis diagnosis. Lung fibrosis was common in these dogs with inbreeding affecting models of lung fibrosis incidence in females but not in males. The apparent protective effect in females predicted by these models of lung fibrosis incidence is likely to be minimal given the small degree of inbreeding in these groups.

Wilson, Dulaney A.; Brigantic, Andrea M.; Morgan, William F.

2011-09-12T23:59:59.000Z

399

Development of a Multicomponent Prediction Model for Acute Esophagitis in Lung Cancer Patients Receiving Chemoradiotherapy  

SciTech Connect

Purpose: To construct a model for the prediction of acute esophagitis in lung cancer patients receiving chemoradiotherapy by combining clinical data, treatment parameters, and genotyping profile. Patients and Methods: Data were available for 273 lung cancer patients treated with curative chemoradiotherapy. Clinical data included gender, age, World Health Organization performance score, nicotine use, diabetes, chronic disease, tumor type, tumor stage, lymph node stage, tumor location, and medical center. Treatment parameters included chemotherapy, surgery, radiotherapy technique, tumor dose, mean fractionation size, mean and maximal esophageal dose, and overall treatment time. A total of 332 genetic polymorphisms were considered in 112 candidate genes. The predicting model was achieved by lasso logistic regression for predictor selection, followed by classic logistic regression for unbiased estimation of the coefficients. Performance of the model was expressed as the area under the curve of the receiver operating characteristic and as the false-negative rate in the optimal point on the receiver operating characteristic curve. Results: A total of 110 patients (40%) developed acute esophagitis Grade {>=}2 (Common Terminology Criteria for Adverse Events v3.0). The final model contained chemotherapy treatment, lymph node stage, mean esophageal dose, gender, overall treatment time, radiotherapy technique, rs2302535 (EGFR), rs16930129 (ENG), rs1131877 (TRAF3), and rs2230528 (ITGB2). The area under the curve was 0.87, and the false-negative rate was 16%. Conclusion: Prediction of acute esophagitis can be improved by combining clinical, treatment, and genetic factors. A multicomponent prediction model for acute esophagitis with a sensitivity of 84% was constructed with two clinical parameters, four treatment parameters, and four genetic polymorphisms.

De Ruyck, Kim, E-mail: kim.deruyck@UGent.be [Department of Basic Medical Sciences, Ghent University, Ghent (Belgium); Sabbe, Nick [Department of Applied Mathematics, Biometrics and Process Control, Ghent University, Ghent (Belgium); Oberije, Cary [Department of Radiation Oncology (MAASTRO Clinic), Research Institute of Growth and Development, Maastricht University Medical Center, Maastricht (Netherlands); Vandecasteele, Katrien [Department of Radiation Oncology, Ghent University Hospital, Ghent (Belgium); Thas, Olivier [Department of Applied Mathematics, Biometrics and Process Control, Ghent University, Ghent (Belgium); De Ruysscher, Dirk; Lambin, Phillipe [Department of Radiation Oncology (MAASTRO Clinic), Research Institute of Growth and Development, Maastricht University Medical Center, Maastricht (Netherlands); Van Meerbeeck, Jan [Department of Respiratory Medicine, Ghent University Hospital, Ghent (Belgium); De Neve, Wilfried [Department of Radiation Oncology, Ghent University Hospital, Ghent (Belgium); Thierens, Hubert [Department of Basic Medical Sciences, Ghent University, Ghent (Belgium)

2011-10-01T23:59:59.000Z

400

Preoperative Chemotherapy Versus Preoperative Chemoradiotherapy for Stage III (N2) Non-Small-Cell Lung Cancer  

Science Conference Proceedings (OSTI)

Purpose: To compare preoperative chemotherapy (ChT) and preoperative chemoradiotherapy (ChT-RT) in operable Stage III non-small-cell lung cancer. Methods and Materials: This retrospective study analyzed all patients with pathologically confirmed Stage III (N2) non-small-cell lung cancer who initiated preoperative ChT or ChT-RT at Duke University between 1995 and 2006. Mediastinal pathologic complete response (pCR) rates were compared using a chi-square test. The actuarial overall survival, disease-free survival, and local control were estimated using the Kaplan-Meier method and compared using the log-rank test. Multivariate Cox regression analysis was also performed. Results: A total of 101 patients who initiated preoperative therapy with planned resection were identified. The median follow-up was 20 months for all patients and 38 months for survivors. The mediastinal lymph nodes were reassessed after preoperative therapy in 88 patients (87%). Within this group, a mediastinal pCR was achieved in 35% after preoperative ChT vs. 65% after preoperative ChT-RT (p = 0.01). Resection was performed in 69% after ChT and 84% after ChT-RT (p = 0.1). For all patients, the overall survival, disease-free survival, and local control rate at 3 years was 40%, 27%, and 66%, respectively. No statistically significant differences were found in the clinical endpoints between the ChT and ChT-RT subgroups. On multivariate analysis, a mediastinal pCR was associated with improved disease-free survival (p = 0.03) and local control (p = 0.03), but not overall survival (p = 0.86). Conclusion: Preoperative ChT-RT was associated with higher mediastinal pCR rates but not improved survival.

Higgins, Kristin, E-mail: kristin.higgins@duke.ed [Department of Radiation Oncology, Duke University of Medical Center, Durham, NC (United States); Chino, Junzo P. [Department of Radiation Oncology, Duke University of Medical Center, Durham, NC (United States); Marks, Lawrence B. [Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC (United States); Ready, Neal [Department of Medicine, Division of Medical Oncology, Duke University of Medical Center, Durham, NC (United States); D'Amico, Thomas A. [Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University of Medical Center, Durham, NC (United States); Clough, Robert W.; Kelsey, Chris R. [Department of Radiation Oncology, Duke University of Medical Center, Durham, NC (United States)

2009-12-01T23:59:59.000Z

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401

Local Failure in Resected N1 Lung Cancer: Implications for Adjuvant Therapy  

SciTech Connect

Purpose: To evaluate actuarial rates of local failure in patients with pathologic N1 non-small-cell lung cancer and to identify clinical and pathologic factors associated with an increased risk of local failure after resection. Methods and Materials: All patients who underwent surgery for non-small-cell lung cancer with pathologically confirmed N1 disease at Duke University Medical Center from 1995-2008 were identified. Patients receiving any preoperative therapy or postoperative radiotherapy or with positive surgical margins were excluded. Local failure was defined as disease recurrence within the ipsilateral hilum, mediastinum, or bronchial stump/staple line. Actuarial rates of local failure were calculated with the Kaplan-Meier method. A Cox multivariate analysis was used to identify factors independently associated with a higher risk of local recurrence. Results: Among 1,559 patients who underwent surgery during the time interval, 198 met the inclusion criteria. Of these patients, 50 (25%) received adjuvant chemotherapy. Actuarial (5-year) rates of local failure, distant failure, and overall survival were 40%, 55%, and 33%, respectively. On multivariate analysis, factors associated with an increased risk of local failure included a video-assisted thoracoscopic surgery approach (hazard ratio [HR], 2.5; p = 0.01), visceral pleural invasion (HR, 2.1; p = 0.04), and increasing number of positive N1 lymph nodes (HR, 1.3 per involved lymph node; p = 0.02). Chemotherapy was associated with a trend toward decreased risk of local failure that was not statistically significant (HR, 0.61; p = 0.2). Conclusions: Actuarial rates of local failure in pN1 disease are high. Further investigation of conformal postoperative radiotherapy may be warranted.

Higgins, Kristin A., E-mail: kristin.higgins@duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Chino, Junzo P. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Berry, Mark [Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC (United States); Ready, Neal [Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC (United States); Boyd, Jessamy [US Oncology, Dallas, TX (United States); Yoo, David S.; Kelsey, Chris R. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)

2012-06-01T23:59:59.000Z

402

Clinical and Dosimetric Predictors of Radiation Pneumonitis in a Large Series of Patients Treated With Stereotactic Body Radiation Therapy to the Lung  

SciTech Connect

Purpose: To report clinical and dosimetric factors predictive of radiation pneumonitis (RP) in patients receiving lung stereotactic body radiation therapy (SBRT) from a series of 240 patients. Methods and Materials: Of the 297 isocenters treating 263 patients, 240 patients (n=263 isocenters) had evaluable information regarding RP. Age, gender, current smoking status and pack-years, O{sub 2} use, Charlson Comorbidity Index, prior lung radiation therapy (yes/no), dose/fractionation, V{sub 5}, V{sub 13}, V{sub 20}, V{sub prescription}, mean lung dose, planning target volume (PTV), total lung volume, and PTV/lung volume ratio were recorded. Results: Twenty-nine patients (11.0%) developed symptomatic pneumonitis (26 grade 2, 3 grade 3). The mean V{sub 20} was 6.5% (range, 0.4%-20.2%), and the average mean lung dose was 5.03 Gy (0.547-12.2 Gy). In univariable analysis female gender (P=.0257) and Charlson Comorbidity index (P=.0366) were significantly predictive of RP. Among dosimetric parameters, V{sub 5} (P=.0186), V{sub 13} (P=.0438), and V{sub prescription} (where dose = 60 Gy) (P=.0128) were significant. There was only a trend toward significance for V{sub 20} (P=.0610). Planning target volume/normal lung volume ratio was highly significant (P=.0024). In multivariable analysis the clinical factors of female gender, pack-years smoking, and larger gross internal tumor volume and PTV were predictive (P=.0094, .0312, .0364, and .052, respectively), but no dosimetric factors were significant. Conclusions: Rate of symptomatic RP was 11%. Our mean lung dose was <600 cGy in most cases and V20 <10%. In univariable analysis, dosimetric factors were predictive, while tumor size (or tumor/lung volume ratio) played a role in multivariable and univariable and analysis, respectively.

Baker, Ryan [University of South Florida School of Medicine, Tampa, Florida (United States)] [University of South Florida School of Medicine, Tampa, Florida (United States); Han Gang [Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida (United States)] [Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida (United States); Sarangkasiri, Siriporn; DeMarco, MaryLou; Turke, Carolyn; Stevens, Craig W. [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida (United States)] [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida (United States); Dilling, Thomas J., E-mail: Thomas.Dilling@Moffitt.org [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida (United States)

2013-01-01T23:59:59.000Z

403

Chest Reirradiation With External Beam Radiotherapy for Locally Recurrent Non-Small-Cell Lung Cancer: A Review  

Science Conference Proceedings (OSTI)

Lung cancer remains one of the most prevalent and deadliest malignancies worldwide. For 2008, the International Agency for the Research of Cancer (IARC) estimated 1.6 million new cancer cases of lung cancer (1.095 million in men and 0.514 million in women), with an associated 1.38 million deaths (0.95 million in men and 0.43 million in women). In the United States, lung cancer remained the number one cancer killer for both sexes in 2009, with 219,440 new cases diagnosed overall and an estimated 159,390 deaths. Recent biological and technological advances in lung cancer management notwithstanding, disease recurrence is still the dominant cause of death after initial treatment of lung cancer. This is irrespective of histology (NSCLC vs. small cell cancer), stage (early vs. locally advanced vs. metastatic), or initial treatment (surgery, RT, chemotherapy [CHT] or combinations thereof). Time to recurrence of lung cancer is not predictable, with some failures appearing early and others manifesting years later. Patterns of failure are also not easily anticipated as local (e.g., lung parenchyma, bronchial stump, or chest wall), regional (e.g., mediastinal lymph nodes), or distant (e.g., brain, liver, or bone) recurrences can appear alone or in combination. Whatever the presentation, recurrent lung cancer has historically been judged almost universally fatal as only rarely did efforts at treatment lead to control, let alone cure. More importantly, recurrence is often associated with significant distress requiring substantial supportive treatment. Recurrence leads ultimately to a significant decrease in patient quality of life, making further interventions even more limited. Because of the bleak outcome associated with recurrence, palliative retreatment has nonetheless often been attempted precisely as a means of preventing this decline in quality of life and/or reversing symptoms. However, complicating these attempts at retreatment has been the forms of initial therapy used to manage the lung cancer, the site of recurrence, and the performance of the patient at relapse. All of these have been relevant to the issue of whether the modality used initially for primary treatment could be both safe and effective in the setting of retreatment. That said, some reports in the surgical literature have suggested, for example, that re-resection in the case of local relapses in selected patients who had previous surgery for stage I lung cancer is feasible and effective and could predict for survival compared to providing the patients with supportive care alone. A particular challenge has been the question of the role and safety of thoracic reirradiation for local recurrences in those patients where RT was used as part of their initial management strategy. Thus, it has been generally assumed that once definitive EBRT has been administered further RT cannot be given because it would likely exceed normal tissue tolerances (6), or, if done, thoracic reirradiation could only be a palliative measure, as the expectation was that patients would not survive to experience potential late effects. A 2007 retrospective study by Estall et al. (4) is instructive in regard to rates of chest reirradiation. Of 527 lung cancer patients treated between 1993 and 1996, the authors reported that 279 (53%) patients were treated at least once with RT, with initial treatment being palliative for 79% of patients, definitive for 14% of patients, and adjuvant for 7% of patients. Of these 279 initial cases, 73 (27%) patients subsequently received a second course of RT, 19 (7%) patients had a third RT course, and 6 (2%) patients received a fourth course. Contemporary technological advances in the diagnosis and staging of lung cancer as well as in the delivery of EBRT, along with the increasing primary role of RT in lung cancer care, now raise the question as to the appropriateness of a palliative-only model for dealing with locally recurrent lung cancer. However, in order to appropriately characterize the historic practice relevant to thoracic reirradiation of recurrent l

Jeremic, Branislav, E-mail: nebareje@gmail.com [Institute of Pulmonary Diseases, Sremska Kamenica (Serbia); Videtic, Gregory M.M. [Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH (United States)

2011-07-15T23:59:59.000Z

404

SU?FF?T?465: Relating Changes in Pulmonary Functin Tests (PFTs) to Changes in Radiation?Induced Regional Lung Perfusion  

Science Conference Proceedings (OSTI)

Purpose: To further assess if RT?induced changes in pulmonary function tests (PFTs) can be prospectively predicted based on the sum of predicted RT?induced changes in regional lung perfusion. Method and Materials: Between 1991 and 2005

J Mao; S Zhou; R Folz; T Wong; L Marks

2006-01-01T23:59:59.000Z

405

Biobased Surfactants and Detergents Synthesis, Properties, and ApplicationsChapter 7 Influence of Pulmonary Surfactant Protein Mimics on Model Lung Surfactant  

Science Conference Proceedings (OSTI)

Biobased Surfactants and Detergents Synthesis, Properties, and Applications Chapter 7 Influence of Pulmonary Surfactant Protein Mimics on Model Lung Surfactant Surfactants and Detergents eChapters Surfactants - Detergents Press &

406

Systematic evaluation of four-dimensional hybrid depth scanning for carbon-ion lung therapy  

Science Conference Proceedings (OSTI)

Purpose: Irradiation of a moving target with a scanning beam requires a comprehensive understanding of organ motion as well as a robust dose error mitigation technique. The authors studied the effects of intrafractional respiratory motion for carbon-ion pencil beam scanning with phase-controlled rescanning on dose distributions for lung tumors. To address density variations, they used 4DCT data. Methods: Dose distributions for various rescanning methods, such as simple layer rescanning (LR), volumetric rescanning, and phase-controlled rescanning (PCR), were calculated for a lung phantom and a lung patient studies. To ensure realism, they set the scanning parameters such as scanning velocity and energy variation time to be similar to those used at our institution. Evaluation metrics were determined with regard to clinical relevance, and consisted of (i) phase-controlled rescanning, (ii) sweep direction, (iii) target motion (direction and amplitude), (iv) respiratory cycle, and (v) prescribed dose. Spot weight maps were calculated by using a beam field-specific target volume, which takes account of range variations for respective respiratory phases. To emphasize the impact of intrafractional motion on the dose distribution, respiratory gating was not used. The accumulated dose was calculated by applying a B-spline-based deformable image registration, and the results for phase-controlled layered rescanning (PCR{sub L}) and phase-controlled volumetric rescanning (PCR{sub V}) were compared. Results: For the phantom study, simple LR was unable to improve the dose distributions for an increased number of rescannings. The phase-controlled technique without rescanning (1 Multiplication-Sign PCR{sub L} and 1 Multiplication-Sign PCR{sub V}) degraded dose conformity significantly due to a reduced scan velocity. In contrast, 4 Multiplication-Sign PCR{sub L} or more significantly and consistently improved dose distribution. PCR{sub V} showed interference effects, but in general also improved dose homogeneity with higher numbers of rescannings. Dose distributions with single PCR{sub L}/PCR{sub V} with a sweep direction perpendicular to motion direction showed large hot/cold spots; however, this effect vanished with higher numbers of rescannings for both methods. Similar observations were obtained for the other dose metrics, such as target motion (SI/AP), amplitude (6-22 mm peak-to-peak) and respiratory period (3.0-5.0 s). For four or more rescannings, both methods showed significantly better results, albeit that volumetric PCR was more affected by interference effects, which lead to severe degradation of a few dose distributions. The clinical example showed the same tendencies as the phantom study. Dose assessment metrics (D95, Dmax/Dmin, homogeneity index) were improved with an increasing number of PCR{sub L}/PCR{sub V}, but with PCR{sub L} being more robust. Conclusions: PCR{sub L} requires a longer treatment time than PCR{sub V} for high numbers of rescannings in the NIRS scanning system but is more robust. Although four or more rescans provided good dose homogeneity and conformity, the authors prefer to use more rescannings for clinical cases to further minimize dose degradation effects due to organ motion.

Mori, Shinichiro; Furukawa, Takuji; Inaniwa, Taku; Zenklusen, Silvan; Nakao, Minoru; Shirai, Toshiyuki; Noda, Koji [Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555 (Japan)

2013-03-15T23:59:59.000Z

407

Biopersistence of man-made vitreous silicate fibers in the human lung. Environ Health Perspect 102(Suppl  

E-Print Network (OSTI)

There is now a substantial body of experimental data on the pulmonary biopersistence of man-made vitreous silicate fibers (MMVSF), but human data are seriously lacking. Our knowledge in this field is essentially limited to a few reports of measurements of fibers retained in lung tissue samples taken at autopsy from workers manufacturing these products. Three types of exposure were studied: fibrous glass, mineral wool, and refractory ceramic fibers. Overall, the available data do not provide evidence for substantial long-term retention of fibers in the human lung after occupational exposure to MMVSF dusts. A word of caution, however; the amount of data supporting the previous statement is much greater for fibrous glass than for either mineral wool or refractory ceramic fibers. There is no human data on the key question of the kinetics of pulmonary clearance of inhaled MMVSF.- Environ Health Perspect 102(Suppl 5):225-228 (1994)

R Sebastien

1994-01-01T23:59:59.000Z

408

Reproducibility of Tumor Motion Probability Distribution Function in Stereotactic Body Radiation Therapy of Lung Cancer  

SciTech Connect

Purpose: To evaluate the reproducibility of tumor motion probability distribution function (PDF) in stereotactic body radiation therapy (SBRT) of lung cancer using cine megavoltage (MV) images. Methods and Materials: Cine MV images of 20 patients acquired during three-dimensional conformal (6-11 beams) SBRT treatments were retrospectively analyzed to extract tumor motion trajectories. For each patient, tumor motion PDFs were generated per fraction (PDF{sub n}) using three selected 'usable' beams. Patients without at least three usable beams were excluded from the study. Fractional PDF reproducibility (R{sub n}) was calculated as the Dice similarity coefficient between PDF{sub n} to a 'ground-truth' PDF (PDF{sub g}), which was generated using the selected beams of all fractions. The mean of R{sub n}, labeled as R{sub m}, was calculated for each patient and correlated to the patient's mean tumor motion rang (A{sub m}). Change of R{sub m} during the course of SBRT treatments was also evaluated. Intra- and intersubject coefficient of variation (CV) of R{sub m} and A{sub m} were determined. Results: Thirteen patients had at least three usable beams and were analyzed. The mean of R{sub m} was 0.87 (range, 0.84-0.95). The mean of A{sub m} was 3.18 mm (range, 0.46-7.80 mm). R{sub m} was found to decrease as A{sub m} increases following an equation of R{sub m} = 0.17e{sup -0.9Am} + 0.84. R{sub m} also decreased slightly throughout the course of treatments. Intersubject CV of R{sub m} (0.05) was comparable to intrasubject CV of R{sub m} (range, 0.02-0.09); intersubject CV of A{sub m} (0.73) was significantly greater than intrasubject CV of A{sub m} (range, 0.09-0.24). Conclusions: Tumor motion PDF can be determined using cine MV images acquired during the treatments. The reproducibility of lung tumor motion PDF decreased exponentially as the tumor motion range increased and decreased slightly throughout the course of the treatments.

Zhang Fan [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States) [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Medical Physics Graduate Program, Duke University, Durham, North Carolina (United States); Hu Jing [Department of Radiation Oncology, National Cancer Centre (Singapore)] [Department of Radiation Oncology, National Cancer Centre (Singapore); Kelsey, Chris R.; Yoo, David [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States)] [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Yin Fangfang [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States) [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Medical Physics Graduate Program, Duke University, Durham, North Carolina (United States); Cai Jing, E-mail: jing.cai@duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Medical Physics Graduate Program, Duke University, Durham, North Carolina (United States)

2012-11-01T23:59:59.000Z

409

Dose-Volume Comparison of Proton Radiotherapy and Stereotactic Body Radiotherapy for Non-Small-Cell Lung Cancer  

Science Conference Proceedings (OSTI)

Purpose: This study designed photon and proton treatment plans for patients treated with hypofractionated proton radiotherapy (PT) at the Southern Tohoku Proton Therapy Center (STPTC). We then calculated dosimetric parameters and compared results with simulated treatment plans for stereotactic body radiotherapy (SBRT), using dose--volume histograms to clearly explain differences in dose distributions between PT and SBRT. Methods and Materials: Twenty-one patients with stage I non-small-cell lung cancer (stage IA, n = 15 patients; stage IB, n = 6 patients) were studied. All tumors were located in the peripheral lung, and total dose was 66 Gray equivalents (GyE) (6.6 GyE/fraction). For treatment planning, beam incidence for proton beam technique was restricted to two to three directions for PT, and seven or eight noncoplanar beams were manually selected for SBRT to achieve optimal planning target volume (PTV) coverage and minimal dose to organs at risk. Results: Regarding lung tissues, mean dose, V5, V10, V13, V15, and V20 values were 4.6 Gy, 13.2%, 11.4%, 10.6%, 10.1%, and 9.1%, respectively, for PT, whereas those values were 7.8 Gy, 32.0%, 21.8%, 17.4%, 15.3%, and 11.4%, respectively, for SBRT with a prescribed dose of 66 Gy. Pearson product moment correlation coefficients between PTV and dose--volume parameters of V5, V10, V15, and V20 were 0.45, 0.52, 0.58, and 0.63, respectively, for PT, compared to 0.52, 0.45, 0.71, and 0.74, respectively, for SBRT. Conclusions: Correlations between dose--volume parameters of the lung and PTV were observed and may indicate that PT is more advantageous than SBRT when treating a tumor with a relatively large PTV or several tumors.

Kadoya, Noriyuki, E-mail: noriyuki_kadoya@yahoo.co.j [Department of Medical Physics, Southern Tohoku Proton Therapy Center, Southern Tohoku Institute of Neuroscience, Koriyama, Fukushima (Japan); Department of Radiological and Medical Sciences, Nagoya University Graduate School of Medicine, Aichi (Japan); Obata, Yasunori [School of Health Sciences, Nagoya University, Nagoya, Aichi (Japan); Kato, Takahiro [Department of Medical Physics, Southern Tohoku Proton Therapy Center, Southern Tohoku Institute of Neuroscience, Koriyama, Fukushima (Japan); Kagiya, Masaru; Nakamura, Tatsuya; Tomoda, Takuya; Takada, Akinori; Takayama, Kanako; Fuwa, Nobukazu [Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Southern Tohoku Research Institute for Neuroscience, Koriyama, Fukushima (Japan)

2011-03-15T23:59:59.000Z

410

CATIONIC SHELL CROSSLINKED NANOPARTICLES AS INTRACELLULAR DELIVERY VEHICLES FOR THE DIAGNOSIS AND TREATMENT OF ACUTE LUNG INJURY  

E-Print Network (OSTI)

Nanomedicine is a growing field of medicine that seeks to take advantage of nanoscale materials in order to address current challenges such as the ability to cross the epithelial mucus of the lungs to deliver treatment. This thesis focuses on the development of polymer nanomaterials known as shell crosslinked knedel-like (SCK) nanoparticles to serve as intracellular carriers of genetic material and specifically target injured cells in the lung for the treatment of acute lung injury (ALI). SCK nanoparticles are spherical in their morphology and their synthesis allows for them to possess tunable functionalities, size, and physical properties. The research presented in this work includes the synthesis of amphiphilic block copolymers that exhibit cationic character in their hydrophilic segment, in order to facilitate cell transfection in the body. The block copolymer poly(acrylamidoethylamine)130-block-polysterene123 (PAEA-b-PS) underwent subsequent micellization in water and crosslinking across the hydrophilic chains. The resulting SCK nanoparticles were c.a 75 nm in diameter and possessed cationic character. Herein, we report the physical and chemical characteristics of the block copolymers, micelles, and crosslinked nanoparticles. Current efforts for refining the synthetic methods in the production of SCK nanoparticles for the treatment of ALI are described.

Florez, Stephanie

2011-05-01T23:59:59.000Z

411

Investigation of the signature of lung tissue in X-ray grating-based phase-contrast imaging  

E-Print Network (OSTI)

Purpose: Grating-based X-ray phase-contrast imaging is a promising modality increasing the soft tissue contrast in medical imaging. In this work, the signature of lung tissue in X-ray grating-based physe-contrast imaging is investigated. Methods: We used a Talbot-Lau interferometer for our investigations of two C57BL/6 mice. Both underwent projection imaging and computed tomography. Results: The results show that the three images obtained by X-ray phase-contrast imaging show complementary anatomical structures. Especially the dark field image allows a more-exact determination of the position of the lung in the chest cavity. Conclusion: Due to its sensitivity to granular structures, the dark field image may be used for the diagnosis of lung diseases in earlier stages or without a CT scan. Furthermore, X-ray phase-contrast imaging may also have great potential in the application of animal laboratory sciences to reduce the number of required animals used in long-term translational, toxicity, and regenerative med...

Weber, Thomas; Haas, Wilhelm; Pelzer, Georg; Rieger, Jens; Ritter, Andr; Wucherer, Lukas; Braun, Jan Matthias; Durst, Jrgen; Michel, Thilo; Anton, Gisela

2012-01-01T23:59:59.000Z

412

Peribronchiolar fibrosis in lungs of cats chronically exposed to diesel exhaust  

SciTech Connect

This study reports the quantitative changes in the pulmonary proximal acinar region following chronic exposure to diesel exhaust and following an additional 6 months in clean air. Cats (13 months of age) from a minimum disease colony were exposed to clean air (eight cats for 27 months and nine cats for 33 months), diesel exhaust for 8 hours/day, 7 days/week (nine cats for 27 months), or diesel exhaust for 27 months followed by 6 months in clean air (10 cats). Morphologic and morphometric evaluation using light microscopy and scanning and transmission electron microscopy revealed two major exposure-related lesions in proximal acinar regions of lungs of cats: peribronchiolar fibrosis associated with significant increases in lymphocytes, fibroblasts, and interstitial macrophages containing diesel particulate-like inclusions and bronchiolar epithelial metaplasia associated with the presence of ciliated and basal cells and alveolar macrophages containing diesel particulate-like inclusions. Peribronchiolar fibrosis was greater at the end of the 6 months in clean air following exposure, whereas the bronchiolar epithelial metaplasia was most severe at the end of exposure. Following an additional 6 months in clean air the epithelium more closely resembled the control epithelial cell population. The labeling index of terminal bronchiolar epithelium was significantly increased at the end of exposure but was not significantly different from controls or exposed cats following an additional 6 months in clean air. The ultrastructural appearance of epithelial cells remained relatively unchanged following diesel exhaust exposure with the exception of diesel particulate-like inclusions.

Hyde, D.M.; Plopper, C.G.; Weir, A.J.; Murnane, R.D.; Warren, D.L.; Last, J.A.; Pepelko, W.E.

1985-02-01T23:59:59.000Z

413

Polymeric Nanoparticles Containing Taxanes Enhance Chemoradiotherapeutic Efficacy in Non-small Cell Lung Cancer  

SciTech Connect

Purpose: To reduce the side effects and improve the efficacy of chemoradiation therapy, taxanes were incorporated into polymeric nanoparticles (PNP), and their synergic effect on radiation therapy in non-small cell lung cancer was evaluated. Methods and Materials: The properties of PNP-taxanes were characterized by transmission electron microscopy and dynamic light scattering. The chemoradiotherapeutic efficacy of PNP-taxanes was determined by clonogenic assay, cellular morphology, and flow cytometry in A549 cells. In mice bearing A549-derived tumors, the tumor growth delay was examined after the treatment of PNP-taxanes and/or ionizing radiation (IR). Results: The PNP-taxanes were found to be approximately 45 nm in average diameter and to have high solubility in water. They showed the properties of active internalization into cells and preserved the anticancer effect of free taxanes. The survival fraction of A549 cells by clonogenic assay was significantly reduced in the group receiving combined treatment of PNP-taxanes and IR. In addition, in vivo radiotherapeutic efficacy was markedly enhanced by the intravenous injection of PNP-taxanes into the xenograft mice. Conclusions: We have demonstrated the feasibility of PNP-taxanes to enhance the efficacy of chemoradiation therapy. These results suggest PNP-taxanes can hold an invaluable and promising position in treating human cancers as a novel and effective chemoradiation therapy agent.

Jung, Joohee [Institute for Innovative Cancer Research, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of) [Institute for Innovative Cancer Research, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); College of Pharmacy, Duksung Women's University, Seoul (Korea, Republic of); Park, Sung-Jin [Institute for Innovative Cancer Research, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of) [Institute for Innovative Cancer Research, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium (Singapore); Chung, Hye Kyung [Center for Development and Commercialization of Anti-cancer Therapeutics, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)] [Center for Development and Commercialization of Anti-cancer Therapeutics, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Kang, Hye-Won; Lee, Sa-Won; Seo, Min Hyo [Department of Parenteral Delivery Program, Samyang Pharmaceuticals R and D, Daejeon (Korea, Republic of)] [Department of Parenteral Delivery Program, Samyang Pharmaceuticals R and D, Daejeon (Korea, Republic of); Park, Heon Joo [Department of Microbiology, College of Medicine, Inha University, Inchon (Korea, Republic of)] [Department of Microbiology, College of Medicine, Inha University, Inchon (Korea, Republic of); Song, Si Yeol [Institute for Innovative Cancer Research, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of) [Institute for Innovative Cancer Research, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Department of Radiation Oncology, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Jeong, Seong-Yun, E-mail: syj@amc.seoul.kr [Institute for Innovative Cancer Research, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)] [Institute for Innovative Cancer Research, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Choi, Eun Kyung, E-mail: ekchoi@amc.seoul.kr [Institute for Innovative Cancer Research, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Department of Radiation Oncology, ASAN Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); College of Pharmacy, Duksung Women's University, Seoul (Korea, Republic of)

2012-09-01T23:59:59.000Z

414

Effect of Recombinant Human Endostatin on Radiosensitivity in Patients With Non-Small-Cell Lung Cancer  

Science Conference Proceedings (OSTI)

Purpose: To observe the effects of recombinant human endostatin (RHES) on the radiosensitivity of non-small cell lung cancer (NSCLC). Methods and Materials: First, 10 hypoxia-positive cases of pathology-diagnosed NSCLC selected from 15 patients were used to determine the normalization window, a period during which RHES improves NSCLC hypoxia. Second, 50 hypoxia-positive cases of pathology-diagnosed NSCLC (Stages I-III) were randomly divided into a RHES plus radiotherapy group (25 cases) and a radiotherapy-alone group (25 cases). Intensity = modulated radiotherapy with a total dose of 60 Gy in 30 fractions for 6 weeks was adopted in the two groups. The target area included primary foci and metastatic lymph nodes. In the RHES plus radiotherapy group, RHES (15 mg/day) was intravenously given during the normalization window. Results: After RHES administration, the tumor-to=normal tissue radioactivity ratio and capillary permeability surface were first decreased and then increased, with their lowest points on the fifth day compared with the first day (all p window is within about 1 week after administration. RHES combined with radiotherapy within the normalization window has better short-term therapeutic effects and local control rates and no severe adverse reactions in the treatment of NSCLC, but it failed to significantly improve the 1-year and 3-year overall survival rates.

Jiang Xiaodong; Dai Peng; Wu Jin; Song Daan [Department of Oncology, Lianyungang First People's Hospital, Lianyungang (China); Yu Jinming, E-mail: jxdysy@sohu.com [Department of Radiation Oncology, Shandong Cancer Hospital, Jinan (China)

2012-07-15T23:59:59.000Z

415

Trends in the use of postoperative radiotherapy for resected non-small-cell lung cancer  

SciTech Connect

Purpose: A 1998 meta-analysis of postoperative radiotherapy (PORT) for non-small-cell lung cancer (NSCLC) found that PORT did not improve outcomes. Yet practice guidelines differ in their recommendations with regard to PORT use. We examine temporal trends in PORT use before and after the 1998 meta-analysis. Methods and Materials: Using data from the Surveillance, Epidemiology, and End Results (SEER) Program, we identified 22,953 patients with Stage I, II, or IIIA NSCLC who had resection between 1992 and 2002 in the United States and characterized each patient according to nodal status (N0, N1, or N2 disease). We measured use of PORT by calendar year. We examined the association between clinical and demographic characteristics and receipt of PORT using logistic regression. Results: For N0, N1, and N2 NSCLC, PORT use has declined. The proportion of patients with N0 disease receiving PORT declined from 8% in 1992 to 4% in 2002. For patients with N1 disease, PORT use declined from 51% in 1992 to 19% in 2002; and for patients with N2 disease, PORT use declined from 65% in 1992 to 37% in 2002. Conclusion: In the context of uncertainty about what constitutes optimal adjuvant treatment for resected NSCLC, PORT use has substantially declined.

Bekelman, Justin E. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)]. E-mail: bekelmaj@mskcc.org; Rosenzweig, Kenneth E. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Bach, Peter B. [Health Outcomes Research Group, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Schrag, Deborah [Health Outcomes Research Group, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

2006-10-01T23:59:59.000Z

416

Charcterization of atrial natriuretic peptide receptors (ANP-R) in rat kidney and lung tissues  

SciTech Connect

The ability of several rat ANP analogues to compete with SVI-ANP(1-28) for binding to plasma membranes of rat kidney cortex (RKPM) and rat lung (RLPM) was examined. Their ability to compete on RKPM was: ANP(1-28)>pro-ANP>ANP(5-28)>ANP(5-27), ANP(5-25) being inactive. Conversely, the potency of the analogues on RLPM was: ANP(5-28)>ANP(5-27)>ANP(1-28)>ANP-(5-25), pro-ANP being unable to compete. The stimulation of particulate guanylate cyclase by these peptides paralleled their ability to compete. Truncation of the C-terminal therefore decreases the binding of the peptide to RKPM. In contrast, the N-terminal seems to be important for interaction with ANP-R on RLPM. ANP-R were photolabeled with SVI-iodo-azidosalicylyl-ANP(1-28) (ASA-ANP) or azidobenzoyl- SVI-ANP(1-28) (AB-ANP) in which the C-terminal tyrosine is iodinated. In ASA-ANP, the iodine is located on the benzene ring. ASA-ANP identified a protein of approx.140 kDa in RKPM. AB-ANP recognized an additional protein of approx.120 kDa. The bulkier N-terminal of the ASA-ANP seems to hinder the binding of the analogue to the approx.120-kDa protein. In RLPM only the approx.120-kDa protein was detected by AB-ANP. The approx.140-kDa receptor may be unique to the kidney. ANF-R in RKPM and RLPM respectively, appear to interact with different domains of ANP suggesting the existence of two forms of the ANP-R.

Tallerico-Melnyk, T.; Yu, H.; Flynn, T.G.; Yip, C.C.

1987-05-01T23:59:59.000Z

417

Gamma Knife Radiosurgery for Treatment of Cerebral Metastases From Non-Small-Cell Lung Cancer  

SciTech Connect

Purpose: To evaluate clinical and physico-dosimetric variables affecting clinical outcome of patients treated with Gamma Knife radiosurgery (GKRS) for brain metastases from non-small cell lung cancer (NSCLC). Methods and Materials: Between 2001 and 2006, 373 patients (298 men and 75 women, median age 65 years) with brain metastases from NSCLC underwent GKRS. All of them had KPS {>=} 60%, eight or fewer brain metastases, confirmed histopathological diagnosis and recent work-up (<3 months). Thirty-five patients belonged to recursive partitioning analysis (RPA) Class I, 307 patients were in RPA Class II, 7 patients were in RPA Class III. Median tumor volume was 3.6 cm{sup 3}. Median marginal dose was 22.5 Gy at 50% isodose.; median 10 Gy and 12 Gy isodose volumes were 30.8 cm{sup 3} and 15.8 cm{sup 3}, respectively. Follow-up with MRI was performed every 3 months. Overall survival data were collected from internal database, telephone interviews, and identifying registries. Results: Mean follow-up after GKRS was 51 months (range, 6 to 96 months); mean overall survival was 14.2 months. Of 373 patients, 29 were alive at time of writing, 104 had died of cerebral progression, and 176 had died of systemic progression. In 64 cases it was not possible to ascertain the cause. Univariate and multivariate analysis were adjusted for the following: RPA class, surgery, WBRT, age, gender, number of lesions, median tumor volume, median peripheral dose, and 10 Gy and 12 Gy volumes. Identified RPA class and overall tumor volume >5 cc were the only two covariates independently predictive of overall survival in patients who died of cerebral progression. Conclusions: Global volume of brain disease should be the main parameter to consider for performing GKRS, which is a first-line therapy for patient in good general condition and controlled systemic disease.

Motta, Micaela, E-mail: motta.micaela@hsr.it [Radiotherapy Department, San Raffaele Scientific Institute, Milan (Italy); Vecchio, Antonella del [Medical Physics Department, San Raffaele Scientific Institute, Milan (Italy); Attuati, Luca; Picozzi, Piero [Neurosurgery Department, San Raffaele Scientific Institute, Milan (Italy); Perna, Lucia [Medical Physics Department, San Raffaele Scientific Institute, Milan (Italy); Franzin, Alberto [Neurosurgery Department, San Raffaele Scientific Institute, Milan (Italy); Bolognesi, Angelo; Cozzarini, Cesare [Radiotherapy Department, San Raffaele Scientific Institute, Milan (Italy); Calandrino, Riccardo [Medical Physics Department, San Raffaele Scientific Institute, Milan (Italy); Mortini, Pietro [Neurosurgery Department, San Raffaele Scientific Institute, Milan (Italy); Muzio, Nadia di [Radiotherapy Department, San Raffaele Scientific Institute, Milan (Italy)

2011-11-15T23:59:59.000Z

418

Risk ranking of bioaccessible metals from fly ash dissolved in simulated lung and gut fluids  

Science Conference Proceedings (OSTI)

Power plant fly ash from two fuels, coal and a mixture of coal and shredded tires were evaluated for trace metal solubility in simulated human lung and gut fluids (SLF and SGF, respectively) to estimate bioaccessibility. The proportion of bioaccessible to total metal ranged from zero (V) to 80% (Zn) for coal-derived ash in SLF and from 2 (Th) to 100% (Cu) for tire-derived fly ash in SGF. The tire-derived ash contained much more Zn. However, Zn ranked only 5th of the various toxic metals in SGF compared with international regulations for ingestion. On the basis of total concentrations, the metals closest to exceeding limits based on international regulations for inhalation were Cr, Pb, and Al. On dissolution in SLF, the most limiting metals were Pb, Cu, and Zn. For metals exposed to SGF there was no relative change in the top metal, Al, before and after dissolution but the second-ranked metal shifted from Pb to Ni. In most cases only a proportion of the total metal concentrations in either fly ash was soluble, and hence bioaccessible, in either biofluid. When considering the regulatory limits for inhalation of particulates, none of the metal concentrations measured were as hazardous as the fly ash particulates themselves. However, on the basis of the international ingestion regulations for Al, the maximum mass of fly ash that could be ingested is only 1 mg per day (10 mg based on bioaccessibility). It is possible that such a small mass could be consumed by exposed individuals or groups. 39 refs., 1 fig., 3 tabs.

John Twining; Peter McGlinn; Elaine Loi; Kath Smith; Reto Giere [Australian Nuclear Science and Technology Organisation, Menai, NSW (Australia)

2005-10-01T23:59:59.000Z

419

Use of Palliative Radiotherapy Among Patients With Metastatic Non-Small-Cell Lung Cancer  

SciTech Connect

Purpose: Radiotherapy (RT) is known to effectively palliate many symptoms of patients with metastatic non-small-cell lung cancer (NSCLC). Anecdotally, RT is believed to be commonly used in this setting, but limited population-based data are available. The objective of this study was to examine the utilization patterns of palliative RT among elderly patients with Stage IV NSCLC and, in particular, to identify factors associated with its use. Methods and Materials: A retrospective population-based cohort study was performed using linked Surveillance, Epidemiology and End Results (SEER)-Medicare data to identify 11,084 Medicare beneficiaries aged {>=}65 years who presented with Stage IV NSCLC in the 11 SEER regions between 1991 and 1996. The primary outcome was receipt of RT. Logistic regression analysis was used to identify factors associated with receipt of RT. Results: A total of 58% of these patients received RT, with its use decreasing over time (p = 0.01). Increasing age was negatively associated with receipt of treatment (p <0.001), as was increasing comorbidities (p <0.001). Factors positively associated with the receipt of RT included income (p = 0.001), hospitalization (p <0.001), and treatment with chemotherapy (p <0.001). Although the use varied across the SEER regions (p = 0.001), gender, race/ethnicity, and distance to the nearest RT facility were not associated with treatment. Conclusions: Elderly patients with metastatic NSCLC frequently receive palliative RT, but its use varies, especially with age and receipt of chemotherapy. Additional research is needed to determine whether this variability reflects good quality care.

Hayman, James A. [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)], E-mail: hayman@umich.edu; Abrahamse, Paul H.; Lakhani, Indu [Department of Internal Medicine, Division of General Medicine, University of Michigan, Ann Arbor, MI (United States); Earle, Craig C. [Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA (United States); Katz, Steven J. [Department of Internal Medicine, Division of General Medicine, University of Michigan, Ann Arbor, MI (United States); Department of Health Management and Policy, University of Michigan, Ann Arbor, MI (United States)

2007-11-15T23:59:59.000Z

420

Impact of Neoadjuvant Radiation on Survival in Stage III Non-Small-Cell Lung Cancer  

Science Conference Proceedings (OSTI)

Purpose: The role of surgery in Stage III non-small-cell lung cancer (NSCLC) is controversial. This study was undertaken to assess the impact of neoadjuvant radiation therapy for Stage III NSCLC. Methods and Materials: This was a retrospective study from the Surveillance, Epidemiology, and End Results (SEER) database that included patients who were 18 years and older with NSCLC classified as Stage III and who underwent definitive therapy from 1988 to 2004. Patients were characterized by type of treatment received. Survival functions were estimated by the Kaplan-Meier method, and Cox regression model was used to analyze trends in overall (OS) and cause-specific survival (CSS). Results: A total of 48,131 patients were selected, with a median follow-up of 10 months (range, 0-203 months). By type of treatment, the 3-year OS was 10% with radiation therapy (RT), 37% with surgery (S), 34% with surgery and postoperative radiation (S-RT), and 45% with neoadjuvant radiation followed by surgery (Neo-RT) (p = 0.0001). Multivariable Cox model identified sex, race, laterality, T stage, N stage, and type of treatment as factors affecting survival. Estimated hazard ratios (HR) adjusted for other variables in regression model showed the types of treatment: S (HR, 1.3; 95% confidence interval [CI], 1.2-1.4), S-RT (HR, 1.2; 95% CI, 1.1-1.3), and RT (HR, 2.3; 95% CI, 2.15-2.53) were associated with significantly worse overall survival when compared with Neo-RT (p = 0.0001). Conclusion: This population based study demonstrates that patients with Stage III NSCLC receiving Neo-RT had significantly improved overall survival when compared with other treatment groups.

Koshy, Matthew, E-mail: mkoshy@umm.ed [Department of Radiation Oncology, University of Maryland School of Medicine and University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD (United States); Goloubeva, Olga; Suntharalingam, Mohan [Department of Radiation Oncology, University of Maryland School of Medicine and University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD (United States)

2011-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

H. R. 3059: A bill to establish a scrap tire trust fund to provide financial assistance to States to eliminate current scrap tire piles and to manage the future disposal of scrap tires, introduced in the US House of Representatives, One Hundred Second Congress, First Session, July 25, 1991  

Science Conference Proceedings (OSTI)

This bill was introduced into the US House of Representatives on July 25, 1991 to establish a scrap tire trust fund to provide financial assistance to states to eliminate current scrap tire piles and to manage the future disposal of scrap tires. Amounts from the fund will be available for making expenditures for purposes of conducting surveys of current scrap tire piles, developing tire management plans, and carrying out plans relating to the reduction and elimination of existing scrap tire piles, including recycling, recovering, and reusing scrap tires. Not in excess to 5% of the account may be used for payment of expenses for administration of the fund.

Not Available

1991-01-01T23:59:59.000Z

422

Cellular morphometry of the bronchi of human and dog lungs. Progress report, April 1, 1991--October 1, 1991  

SciTech Connect

One hundred and forty-seven bronchial samples (generations 3--6) from 66 patients (62 usable; 36 female, 26 male; median age 61) have been dissected by generation from fixed surgical lung specimens obtained after the removal of pathological lesions. In addition, one hundred and fifty-six mongol dog bronchi (generations 2--6) dissected from different lobes of 26 dog lungs have also been similarly prepared. One hundred and twenty-seven human samples have been completely processed for electron microscopy and have yielded 994 electron micrographs of which 655 have been entered into the Computerized Stereological Analysis System (COSAS) and been used for the measurement of the distances of basal and mucous cell nuclei to the epithelial free surface. Similarly 328 micrographs of dog epithelium from 33 bronchial samples have been used to measure the distances of basal and mucous cell nuclei to the epithelial free surface and have been entered into COSAS. Using the COSAS planimetry program, we continue to expand our established data bases which describe the volume density and nuclear numbers per electron micrograph for 5 cell types of the human bronchial epithelial lining of men and women, as well as smokers, non-smokers and ex-smokers and similar parameters for the same 5 epithelial cell types of dog bronchi. Our micrographs of human bronchial epithelium have allowed us to analyze the recent suggestion that the DNA of lymphocytes may be subject to significant damage from Rn progeny while within the lung. Since the last progress report three papers have been submitted for publication. 17 refs., 4 tabs.

Robbins, E.S.

1991-09-01T23:59:59.000Z

423

Respiration-Correlated Image Guidance Is the Most Important Radiotherapy Motion Management Strategy for Most Lung Cancer Patients  

Science Conference Proceedings (OSTI)

Purpose: The purpose of this study was to quantify the effects of four-dimensional computed tomography (4DCT), 4D image guidance (4D-IG), and beam gating on calculated treatment field margins in a lung cancer patient population. Materials and Methods: Images were acquired from 46 lung cancer patients participating in four separate protocols at three institutions in Europe and the United States. Seven patients were imaged using fluoroscopy, and 39 patients were imaged using 4DCT. The magnitude of respiratory tumor motion was measured. The required treatment field margins were calculated using a statistical recipe (van Herk M, et al. Int J Radiat Oncol Biol Phys 2000;474:1121-1135), with magnitudes of all uncertainties, except respiratory peak-to-peak displacement, the same for all patients, taken from literature. Required margins for respiratory motion management were calculated using the residual respiratory tumor motion for each patient for various motion management strategies. Margin reductions for respiration management were calculated using 4DCT, 4D-IG, and gated beam delivery. Results: The median tumor motion magnitude was 4.4 mm for the 46 patients (range 0-29.3 mm). This value corresponded to required treatment field margins of 13.7 to 36.3 mm (median 14.4 mm). The use of 4DCT, 4D-IG, and beam gating required margins that were reduced by 0 to 13.9 mm (median 0.5 mm), 3 to 5.2 mm (median 5.1 mm), and 0 to 7 mm (median 0.2 mm), respectively, to a total of 8.5 to 12.4 mm (median 8.6 mm). Conclusion: A respiratory management strategy for lung cancer radiotherapy including planning on 4DCT scans and daily image guidance provides a potential reduction of 37% to 47% in treatment field margins. The 4D image guidance strategy was the most effective strategy for >85% of the patients.

Korreman, Stine, E-mail: korreman@ruc.dk [Department of Science, Systems and Models, Roskilde University, Roskilde (Denmark); Department of Radiation Oncology, The Finsen Centre, Rigshospitalet, Copenhagen (Denmark); Niels Bohr Institute, University of Copenhagen, Copenhagen (Denmark); Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison (United States); Persson, Gitte; Nygaard, Ditte [Department of Radiation Oncology, The Finsen Centre, Rigshospitalet, Copenhagen (Denmark); Brink, Carsten [Laboratory of Radiation Physics, Odense University Hospital, Odense (Denmark); Faculty of Health Sciences, University of Southern Denmark, Odense (Denmark); Juhler-Nottrup, Trine [Department of Oncology, Herlev Hospital, Copenhagen (Denmark)

2012-07-15T23:59:59.000Z

424

Stories of the Unheard: A Case Study of Five Mexican American Dropouts Labeled as Demonstrating Learning Disabilities  

E-Print Network (OSTI)

This qualitative study examined the dropout crises from the perspectives of Mexican American dropouts labeled as learner disabled who were receiving special education services. Such study is imperative as this group increases both in school and in special education classes. There were two research questions that guided the study: 1. What are the perceptions of Mexican American dropouts who participated in a special education program regarding their educational experiences? 2. What were the factors that influenced these students decisions to drop out of school? From the participant interviews, historical academic documents, and rich-descriptive information gathered from the students voices, three themes were revealed as the primary reason for dropping out of school: non-responsive school culture, lack of supportive environment, and social factors. It was evident in the data collected that the school culture was unfavorable toward their learning and in meeting successful graduation requirements. Under non-responsive school culture, the following subthemes emerged as underlining factors to their dropping out: (a) low expectations, (b) non-caring for the student, (c) ineffective curriculum content, and (d) social issues at school. School-related factors such as the lack of a supportive environment revealed the following subthemes: (a) symptoms of school failure, (b) negative learning environment, and (c) culturally non-responsive instruction. Other attributing factors for dropping out of school included family structures and peer pressure. While each of the participants had unique experiences, each attributed non-responsive school culture, lack of supportive environment, and social context as major factors for dropping out of school. Therefore, the significance of this study lies in the potential to impact Mexican American student achievement in the reduction of dropouts.

Villafranca, Darlene 1975-

2012-12-01T23:59:59.000Z

425

Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue  

SciTech Connect

The purpose of this study was to evaluate the therapeutic efficacy of Re-188-RC-160 in experimental models of human small cell lung carcinomas which mimic the clinical presentation. In the experimental model, cells from the human small cell lung carcinoma cell line NCI-H69 cells were inoculated into the thoracic cavity of athymic mice and rats. Subsequently, the biodistribution of Re-188-RC-160 after injection into the pleural cavity, a radiolabeled somatostatin analogue, was monitored as was the effect on the subsequent growth of tumors. The results presented here, and which are a part of a larger series of studies, suggest that Re-188-RC-160 can be effectively used in this animal model to restrict the growth of small cell lung carcinoma in the thoracic cavity.

Zamora, P.O. [Univ. of Bonn (Germany). Dept. of Nuclear Medicine]|[RhoMed Inc., Albuquerque, NM (United States); Bender, H.; Biersack, H.J. [Univ. of Bonn (Germany). Dept. of Nuclear Medicine; Knapp, F.F. Jr. [Oak Ridge National Lab., TN (United States). Health Sciences Research Div.

1995-07-01T23:59:59.000Z

426

Converging Stereotactic Radiotherapy Using Kilovoltage X-Rays: Experimental Irradiation of Normal Rabbit Lung and Dose-Volume Analysis With Monte Carlo Simulation  

Science Conference Proceedings (OSTI)

Purpose: To validate the feasibility of developing a radiotherapy unit with kilovoltage X-rays through actual irradiation of live rabbit lungs, and to explore the practical issues anticipated in future clinical application to humans through Monte Carlo dose simulation. Methods and Materials: A converging stereotactic irradiation unit was developed, consisting of a modified diagnostic computed tomography (CT) scanner. A tiny cylindrical volume in 13 normal rabbit lungs was individually irradiated with single fractional absorbed doses of 15, 30, 45, and 60 Gy. Observational CT scanning of the whole lung was performed every 2 weeks for 30 weeks after irradiation. After 30 weeks, histopathologic specimens of the lungs were examined. Dose distribution was simulated using the Monte Carlo method, and dose-volume histograms were calculated according to the data. A trial estimation of the effect of respiratory movement on dose distribution was made. Results: A localized hypodense change and subsequent reticular opacity around the planning target volume (PTV) were observed in CT images of rabbit lungs. Dose-volume histograms of the PTVs and organs at risk showed a focused dose distribution to the target and sufficient dose lowering in the organs at risk. Our estimate of the dose distribution, taking respiratory movement into account, revealed dose reduction in the PTV. Conclusions: A converging stereotactic irradiation unit using kilovoltage X-rays was able to generate a focused radiobiologic reaction in rabbit lungs. Dose-volume histogram analysis and estimated sagittal dose distribution, considering respiratory movement, clarified the characteristics of the irradiation received from this type of unit.

Kawase, Takatsugu [Department of Radiology, Keio University School of Medicine, Tokyo (Japan); CREST, Japan Science and Technology Agency, Tokyo (Japan); Kunieda, Etsuo [Department of Radiology, Keio University School of Medicine, Tokyo (Japan); CREST, Japan Science and Technology Agency, Tokyo (Japan)], E-mail: kunieda-mi@umin.ac.jp; Deloar, Hossain M. [CREST, Japan Science and Technology Agency, Tokyo (Japan); Oncology Service, Medical Physics and Bioengineering Department, Christchurch Hospital, Christchurch (New Zealand); Tsunoo, Takanori [Department of Radiology, Keio University School of Medicine, Tokyo (Japan); CREST, Japan Science and Technology Agency, Tokyo (Japan); Seki, Satoshi [Department of Radiology, Keio University School of Medicine, Tokyo (Japan); Oku, Yohei [CREST, Japan Science and Technology Agency, Tokyo (Japan); Department of Radiology, Keio University School of Medicine, Tokyo (Japan); Saitoh, Hidetoshi [Division of Radiological Sciences, Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo (Japan); CREST, Japan Science and Technology Agency, Tokyo (Japan); Saito, Kimiaki [Center for Promotion of Computational Science and Engineering, Japan Atomic Energy Agency, Ibaraki (Japan); CREST, Japan Science and Technology Agency, Tokyo (Japan); Ogawa, Eileen N. [Department of Anesthesiology, Keio University School of Medicine, Tokyo (Japan); Ishizaka, Akitoshi [Department of Medicine, Keio University School of Medicine, Tokyo (Japan); Kameyama, Kaori [Division of Diagnostic Pathology, Keio University School of Medicine, Tokyo (Japan); Kubo, Atsushi [Department of Radiology, Keio University School of Medicine, Tokyo (Japan)

2009-10-01T23:59:59.000Z

427

Changes in Pulmonary Function After Three-Dimensional Conformal Radiotherapy, Intensity-Modulated Radiotherapy, or Proton Beam Therapy for Non-Small-Cell Lung Cancer  

Science Conference Proceedings (OSTI)

Purpose: To investigate the extent of change in pulmonary function over time after definitive radiotherapy for non-small-cell lung cancer (NSCLC) with modern techniques and to identify predictors of changes in pulmonary function according to patient, tumor, and treatment characteristics. Patients and Methods: We analyzed 250 patients who had received {>=}60 Gy radio(chemo)therapy for primary NSCLC in 1998-2010 and had undergone pulmonary function tests before and within 1 year after treatment. Ninety-three patients were treated with three-dimensional conformal radiotherapy, 97 with intensity-modulated radiotherapy, and 60 with proton beam therapy. Postradiation pulmonary function test values were evaluated among individual patients compared with the same patient's preradiation value at the following time intervals: 0-4 (T1), 5-8 (T2), and 9-12 (T3) months. Results: Lung diffusing capacity for carbon monoxide (DLCO) was reduced in the majority of patients along the three time periods after radiation, whereas the forced expiratory volume in 1 s per unit of vital capacity (FEV1/VC) showed an increase and decrease after radiation in a similar percentage of patients. There were baseline differences (stage, radiotherapy dose, concurrent chemotherapy) among the radiation technology groups. On multivariate analysis, the following features were associated with larger posttreatment declines in DLCO: pretreatment DLCO, gross tumor volume, lung and heart dosimetric data, and total radiation dose. Only pretreatment DLCO was associated with larger posttreatment declines in FEV1/VC. Conclusions: Lung diffusing capacity for carbon monoxide is reduced in the majority of patients after radiotherapy with modern techniques. Multiple factors, including gross tumor volume, preradiation lung function, and dosimetric parameters, are associated with the DLCO decline. Prospective studies are needed to better understand whether new radiation technology, such as proton beam therapy or intensity-modulated radiotherapy, may decrease the pulmonary impairment through greater lung sparing.

Lopez Guerra, Jose L. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Hospitales Universitarios Virgen del Rocio, Seville (Spain); Department of Medicine, Universitat Autonoma de Barcelona, Barcelona (Spain); Gomez, Daniel R., E-mail: dgomez@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang Yan; Levy, Lawrence B. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Eapen, George [Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liu, Hongmei; Mohan, Radhe; Komaki, Ritsuko; Cox, James D.; Liao Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2012-07-15T23:59:59.000Z

428

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer  

E-Print Network (OSTI)

sections from 331 NSCLC patients, who had undergone surgical resection. Immunohistochemistry using an MCM7-specific anti- body showed nuclear localization in cancer tissues, but nothing was detected in normal lung tissues (Figure 1B). Importantly, specific... ;#27; #20; C Normal tissues (n = 11) NSCLC (n = 6) SCLC (n = 3) ** NS* R el at iv e m R N A e xp re ss io n le ve ls o f M CM 7 A Normal lungMCM7 positive ?100 ?200 ?200 ?200 B D MCM7 positive (n = 196) MCM7 negative (n = 135) 0 20 40 60 80 100 0 500...

Toyokawa, Gouji; Masuda, Ken; Daigo, Yataro; Cho, Hyun-Soo; Yoshimatsu, Masanori; Takawa, Masashi; Hayami, Shinya; Maejima, Kazuhiro; Chino, Makoto; Field, Helen I; Neal, David E; Tsuchiya, Eiju; Ponder, Bruce A J; Maehara, Yoshihiko; Nakamura, Yusuke; Hamamoto, Ryuji

2011-05-28T23:59:59.000Z

429

Development of a Rhesus Monkey Lung Geometry Model and Application to Particle Deposition in Comparison to Humans  

SciTech Connect

The exposure-dose-response characterization of an inhalation hazard established in an animal species needs to be translated to an equivalent characterization in humans relative to comparable doses or exposure scenarios. Here, the first geometry model of the conducting airways for rhesus monkeys is developed based upon CT images of the conducting airways of a 6-month-old male, rhesus monkey. An algorithm was developed for adding the alveolar region airways using published rhesus morphometric data. The resultant lung geometry model can be used in mechanistic particle or gaseous dosimetry models. Such dosimetry models require estimates of the upper respiratory tract volume of the animal and the functional residual capacity, as well as of the tidal volume and breathing frequency of the animal. The relationship of these variables to rhesus monkeys of differing body weights was established by synthesizing and modeling published data as well as modeling pulmonary function measurements on 121 rhesus control animals. Deposition patterns of particles up to 10 ?m in size were examined for endotracheal and and up to 5 ?m for spontaneous breathing in infant and young adult monkeys and compared to those for humans. Deposition fraction of respirable size particles was found to be higher in the conducting airways of infant and young adult rhesus monkeys compared to humans. Due to the filtering effect of the conducting airways, pulmonary deposition in rhesus monkeys was lower than that in humans. Future research areas are identified that would either allow replacing assumptions or improving the newly developed lung model.

Asgharian, Bahman; Price, Owen; McClellan, Gene; Corley, Richard A.; Einstein, Daniel R.; Jacob, Rick E.; Harkema, Jack R.; Carey, Stephen A.; Schelegle, Edward; Hyde, D.; Kimbell, Julia; Miller, Frederick J.

2012-11-01T23:59:59.000Z

430

Stereotactic Radiotherapy of Primary Lung Cancer and Other Targets: Results of Consultant Meeting of the International Atomic Energy Agency  

Science Conference Proceedings (OSTI)

To evaluate the current status of stereotactic body radiotherapy (SBRT) and identify both advantages and disadvantages of its use in developing countries, a meeting composed of consultants of the International Atomic Energy Agency was held in Vienna in November 2006. Owing to continuous developments in the field, the meeting was extended by subsequent discussions and correspondence (2007-2010), which led to the summary presented here. The advantages and disadvantages of SBRT expected to be encountered in developing countries were identified. The definitions, typical treatment courses, and clinical results were presented. Thereafter, minimal methodology/technology requirements for SBRT were evaluated. Finally, characteristics of SBRT for developing countries were recommended. Patients for SBRT should be carefully selected, because single high-dose radiotherapy may cause serious complications in some serial organs at risk. Clinical experiences have been reported in some populations of lung cancer, lung oligometastases, liver cancer, pancreas cancer, and kidney cancer. Despite the disadvantages expected to be experienced in developing countries, SBRT using fewer fractions may be useful in selected patients with various extracranial cancers with favorable outcome and low toxicity.

Nagata, Yasushi, E-mail: nagat@hiroshima-u.ac.j [Hiroshima University Hospital, Department of Radiation Oncology, Hiroshima (Japan); Wulf, Joern [Institut of Radiation Oncology, Lindenhospital, Bern (Switzerland); Lax, Ingmar [Division of Oncology and Hospital Physics, Radiumhemmet, Karolinska University Hospital (Sweden); Timmerman, Robert [Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas (United States); Zimmermann, Frank [Department of Radiation Oncology, University Hospital, University Basel, Basel (Switzerland); Stojkovski, Igor; Jeremic, Branislav [International Atomic Energy Agency, Vienna (Austria)

2011-03-01T23:59:59.000Z

431

NSTIC, Trusted IDs: Benefits for Business  

Science Conference Proceedings (OSTI)

... This tremendous increase in online business transactions, however, gives cyber criminals greater access to business assets than ever before ...

432

National Strategy for Trusted Identities in Cyberspace  

Science Conference Proceedings (OSTI)

... Many people don't even try; they just re-use the same ones for all ... For example, student Jane Smith could get a digital credential from her cell phone ...

433

DYER ISLAND CONSERVATION TRUST LETTER OF CONCERN  

E-Print Network (OSTI)

-weekly from the cooling-water intake screens of the Nuclear Power Plant Doel, located in the brackish part of the Zeeschelde (Figure 1). Sampling started in July 1994 and finished in June 1995. The cooling- water intake on cooling- water intake data of seven English coastal power plants. In addition, the species number

de Villiers, Marienne

434

Do You Trust Derivatives or Differences??  

E-Print Network (OSTI)

partment of Energy, under Contract DE-AC02-06CH11357. ...... of Advanced Scientific Computing Research, Office of Science, U.S. Department of Energy,.

435

A FEASIBLE TRUST-REGION SEQUENTIAL QUADRATIC ...  

E-Print Network (OSTI)

TEXAS-WISCONSIN MODELING AND CONTROL CONSORTIUM REPORT ... Chemical Engineering Department, University of Wisconsin, Madison, WI 53706, ...

436

National Strategy for Trusted Identities in Cyberspace  

Science Conference Proceedings (OSTI)

... productivity and innovation while reducing losses for businesses and better ... improved the resilience of data breach recovery through the use of ...

2012-02-13T23:59:59.000Z

437

National Strategy for Trusted Identities in Cyberspace  

Science Conference Proceedings (OSTI)

... performance objectives. Can include a Gantt chart, Work Breakdown Structure or other format to present plan (not included in the page count). ...

2013-06-07T23:59:59.000Z

438

ON EFFICIENTLY COMBINING LIMITED MEMORY AND TRUST ...  

E-Print Network (OSTI)

... Euclidean norm with an insignificant computational overhead compared with the cost of computing the quasi-Newton direction in line-search limited memory...

439

Catalog Record: Atomwirtschaft, Atomtechnik | Hathi Trust Digital ...  

U.S. Energy Information Administration (EIA)

Similar Items. Reaktortagung, Karlsurhe : 10. April-13. April, 1973, Stadthalle Universitt. By: Reaktortagung Karlsruhe) Published: (1973)

440

PARS II Configuration Update - Trusted Publisher  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Office Excel 2010 (32-bit) 1. Start Microsoft Office Excel 2010. 2. Click on the "File" tab on the upper left. 3. Click on the "Options" menu on the lower left. 4. On the left...

Note: This page contains sample records for the topic "lung disability trust" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Autonomic and trusted computing for ubiquitous intelligence  

Science Conference Proceedings (OSTI)

The world of matter was understood clearly only by finding its invariants such as mass and energy. From the invariants, physics has derived theories to govern the whole material world as variants. Cyberworlds are information worlds. Hence, finding the ...

Tosiyasu L. Kunii

2007-07-01T23:59:59.000Z

442

Title: Managing Trust within an Organization Covering ...  

Science Conference Proceedings (OSTI)

... utilizing these technologies to ensure efficient business operations without ... at how this methodology can be used to improve continuity of operations ...

2013-03-12T23:59:59.000Z

443

Trust Anchor Fact Sheet.cdr  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

secure software providing independent testing, monitoring, and control of energy control system component operation Cryptographically secure software providing independent...

444

Enhancing Trust by Enhancing the Audit Process  

Science Conference Proceedings (OSTI)

... Focussing on security ? Clear requirements what is to be audited in the audit ? Accreditation of auditors and Certification of CAs Jens Bender ...

2013-04-10T23:59:59.000Z

445

Trusted Computer System Evaluation Criteria ["Orange Book"  

Science Conference Proceedings (OSTI)

Page 1. DoD 5200.28-STD Supersedes CSC-STD-00l-83, dtd l5 Aug 83 Library No. S225,7ll DEPARTMENT OF DEFENSE STANDARD ...

2013-04-16T23:59:59.000Z

446

General and Familiar Trust in Websites  

E-Print Network (OSTI)

P. (2010, April 27). Nobody Can Stop Facebook BecauseNobody Understands Facebook. Retrieved April2010/04/27/nobody-can-stop-facebook/ Chen, S. C. , &

Cheshire, Coye; Antin, Judd; Cook, Karen S.; Churchill, Elizabeth

2010-01-01T23:59:59.000Z

447

Hardware trust implications of 3-D integration  

Science Conference Proceedings (OSTI)

3-D circuit-level integration is a chip fabrication technique in which two or more dies are stacked and combined into a single circuit through the use of vertical electroconductive posts. Since the dies may be manufactured separately, 3-D circuit integration ...

Ted Huffmire; Timothy Levin; Michael Bilzor; Cynthia E. Irvine; Jonathan Valamehr; Mohit Tiwari; Timothy Sherwood; Ryan Kastner

2010-10-01T23:59:59.000Z

448

Preclinical and Pilot Clinical Studies of Docetaxel Chemoradiation for Stage III Non-Small-Cell Lung Cancer  

Science Conference Proceedings (OSTI)

Purpose: Local and distant failure rates remain high despite aggressive chemoradiation (CRT) treatment for Stage III non-small-cell lung cancer. We conducted preclinical studies of docetaxel's cytotoxic and radiosensitizing effects on lung cancer cell lines and designed a pilot study to target distant micrometastasis upfront with one-cycle induction chemotherapy, followed by low-dose radiosensitizing docetaxel CRT. Methods and Materials: A preclinical study was conducted in human lung cancer cell lines NCI 520 and A549. Cells were treated with two concentrations of docetaxel for 3 h and then irradiated immediately or after a 24-h delay. A clonogenic survival assay was conducted and analyzed for cytotoxic effects vs. radiosensitizing effects of docetaxel. A pilot clinical study was designed based on preclinical study findings. Twenty-two patients were enrolled with a median follow-up of 4 years. Induction chemotherapy consisted of 75 mg/m{sup 2} of docetaxel and 75 mg/m{sup 2} of cisplatin on Day 1 and 150 mg/m{sup 2} of recombinant human granulocyte colony-stimulating factor on Days 2 through 10. Concurrent CRT was started 3 to 6 weeks later with twice-weekly docetaxel at 10 to 12 mg/m{sup 2} and daily delayed radiation in 1.8-Gy fractions to 64.5 Gy for gross disease. Results: The preclinical study showed potent cytotoxic effects of docetaxel and subadditive radiosensitizing effects. Delaying radiation resulted in more cancer cell death. The pilot clinical study resulted in a median survival of 32.6 months for the entire cohort, with 3- and 5-year survival rates of 50% and 19%, respectively, and a distant metastasis-free survival rate of 61% for both 3 and 5 years. A pattern-of-failure analysis showed 75% chest failures and 36% all-distant failures. Therapy was well tolerated with Grade 3 esophagitis observed in 23% of patients. Conclusions: One-cycle full-dose docetaxel/cisplatin induction chemotherapy with recombinant human granulocyte colony-stimulating factor followed by pulsed low-dose docetaxel CRT is promising with regard to its antitumor activity, low rates of distant failure, and low toxicity, suggesting that this regimen deserves further investigation.

Chen Yuhchyau, E-mail: yuhchyau_chen@urmc.rochester.edu [Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY (United States); Pandya, Kishan J. [Department of Medical Oncology, University of Rochester Medical Center, Rochester, NY (United States); Hyrien, Ollivier [Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY (United States); Keng, Peter C.; Smudzin, Therese; Anderson, Joy [Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY (United States); Qazi, Raman; Smith, Brian [Department of Medical Oncology, University of Rochester Medical Center, Rochester, NY (United States); Watson, Thomas J. [Division of Cardiothoracic Surgery, University of Rochester Medical Center, Rochester, NY (United States); Feins, Richard H. [Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC (United States); Johnstone, David W. [Division of Cardiothoracic Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH (Lebanon)

2011-08-01T23:59:59.000Z

449

This lesson plan is part of the National Heart, Lung, and Blood Institute's (NHLBI) heart attack education campaign, Act in Time to Heart Attack Signs.  

E-Print Network (OSTI)

#12;#12;#12;This lesson plan is part of the National Heart, Lung, and Blood Institute's (NHLBI) heart attack education campaign, Act in Time to Heart Attack Signs. It was designed to be the 10th session of an existing 9-session heart health education course for Latinos entitled Your Heart, Your Life

Bandettini, Peter A.

450

JAVA SCRIPT IS DISABLED  

Office of Scientific and Technical Information (OSTI)

This application needs JavaScript to work correctly but your browser does not have it enabled. How do I enable JavaScript??? - follow the instructions below... If your browser is not listed, please contact your system administrator. Internet Explorer (6.0) Select 'Tools' from the top menu Choose 'Internet Options' Click on the 'Security' tab Click on 'Custom Level' Scroll down until you see section labled 'Scripting' Under 'Active Scripting', select 'Enable' and click OK Internet Explorer (7.0) Select Tools > Internet Options. Click on the Security tab. Click the Custom Level button. Scroll down to the Scripting section. Select Enable for Active Scripting and Scripting of Java Applets. Click OK. Select YES if a box appears to confirm. Click OK. Close window.

451

Effects of mutant human Ki-ras{sup G12C} gene dosage on murine lung tumorigenesis and signaling to its downstream effectors  

Science Conference Proceedings (OSTI)

Studies in cell culture have suggested that the level of RAS expression can influence the transformation of cells and the signaling pathways stimulated by mutant RAS expression. However, the levels of RAS expression in vivo appear to be subject to feedback regulation, limiting the total amount of RAS protein that can be expressed. We utilized a bitransgenic mouse lung tumor model that expressed the human Ki-ras{sup G12C} allele in a tetracycline-inducible, lung-specific manner. Treatment for 12 months with 500 {mu}g/ml of doxycycline (DOX) allowed for maximal expression of the human Ki-ras{sup G12C} allele in the lung, and resulted in the development of focal hyperplasia and adenomas. We determined if different levels of mutant RAS expression would influence the phenotype of the lung lesions. Treatment with 25, 100 and 500 {mu}g/ml of DOX resulted in dose-dependent increases in transgene expression and tumor multiplicity. Microscopic analysis of the lungs of mice treated with the 25 {mu}g/ml dose of DOX revealed infrequent foci of hyperplasia, whereas mice treated with the 100 and 500 {mu}g/ml doses exhibited numerous hyperplastic foci and also adenomas. Immunohistochemical and RNA analysis of the downstream effector pathways demonstrated that different levels of mutant RAS transgene expression resulted in differences in the expression and/or phosphorylation of specific signaling molecules. Our results suggest that the molecular alterations driving tumorigenesis may differ at different levels of mutant Ki-ras{sup G12C} expression, and this should be taken into consideration when inducible transgene systems are utilized to promote tumorigenesis in mouse models.

Dance-Barnes, Stephanie T. [Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157 (United States); Kock, Nancy D. [Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157 (United States); Floyd, Heather S. [Department of Molecular Biomedical Sciences, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606 (United States); Moore, Joseph E.; Mosley, Libyadda J. [Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157 (United States); D'Agostino, Ralph B. [Section on Biostatistics, Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157 (United States); Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC 27157 (United States); Pettenati, Mark J. [Department of Medical Genetics, Wake Forest University School of Medicine, Winston-Salem, NC 27157 (United States); Miller, Mark Steven [Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157 (United States); Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC 27157 (United States)], E-mail: msmiller@wfubmc.edu

2008-08-15T23:59:59.000Z

452

Comparison of Survival Rate in Primary Non-Small-Cell Lung Cancer Among Elderly Patients Treated With Radiofrequency Ablation, Surgery, or Chemotherapy  

Science Conference Proceedings (OSTI)

Purpose: We retrospectively compared the survival rate in patients with non-small-cell lung cancer (NSCLC) treated with radiofrequency ablation (RFA), surgery, or chemotherapy according to lung cancer staging. Materials and Methods: From 2000 to 2004, 77 NSCLC patients, all of whom had WHO performance status 0-2 and were >60 years old, were enrolled in a cancer registry and retrospectively evaluated. RFA was performed on patients who had medical contraindications to surgery/unsuitability for surgery, such as advanced lung cancer or refusal of surgery. In the RFA group, 40 patients with inoperable NSCLC underwent RFA under computed tomography (CT) guidance. These included 16 patients with stage I to II cancer and 24 patients with stage III to IV cancer who underwent RFA in an adjuvant setting. In the comparison group (n = 37), 13 patients with stage I to II cancer underwent surgery; 18 patients with stage III to IV cancer underwent chemotherapy; and 6 patients with stage III to IV cancer were not actively treated. The survival curves for RFA, surgery, and chemotherapy in these patients were calculated using Kaplan-Meier method. Results: Median survival times for patients treated with (1) surgery alone and (2) RFA alone for stage I to II lung cancer were 33.8 and 28.2 months, respectively (P = 0.426). Median survival times for patients treated with (1) chemotherapy alone and (2) RFA with chemotherapy for stage III to IV cancer were 29 and 42 months, respectively (P = 0.03). Conclusion: RFA can be used as an alternative treatment to surgery for older NSCLC patients with stage I to II inoperable cancer and can play a role as adjuvant therapy with chemotherapy for patients with stage III to IV lung cancer.

Lee, Heon [Seoul Medical Center, Department of Radiology (Korea, Republic of); Jin, Gong Yong, E-mail: gyjin@chonbuk.ac.kr; Han, Young Min; Chung, Gyung Ho [Chonbuk National University Medical School, Department of Radiology, Research Institute of Clinical Medicine (Korea, Republic of); Lee, Yong Chul [Chonbuk National University Medical School, Department of Internal Medicine, Research Institute of Clinical Medicine (Korea, Republic of); Kwon, Keun Sang [Chonbuk National University Medical School, Department of Preventive Medicine, Research Institute of Clinical Medicine (Korea, Republic of); Lynch, David [National Jewish Health, Interstitial and Autoimmune Lung Disease Program, Department of Radiology (United States)

2012-04-15T23:59:59.000Z

453

Cellular morphometry of the bronchi of human and dog lungs. Annual progress report, April 1, 1992--March 31, 1993  

SciTech Connect

Quantitative data of the human bronchial epithelial cells at possible risk for malignant transformation in lung cancer is crucial for accurate radon dosimetry and risk analysis. The locations and other parameters of the nuclei which may be damaged by {alpha} particles must be determined and compared in different airway generations, among smokers, non-smokers and ex-smokers, between men and women and in people of different ages. This proposal includes extended morphometric studies on electron micrographs of human epithelium of defined airway generations and in parallel on electron micrographs of the dog bronchial lining. The second part of this proposal describes studies to quantitate the cycling bronchial epithelial population(s) using proliferation markers and immunocytochemistry on frozen and paraffin sections and similar labeling of isolated bronchial epithelial cells sorted flow cytometry.

Robbins, E.S.

1992-09-01T23:59:59.000Z

454

Stereotactic Body Radiotherapy for Medically Inoperable Lung Cancer: Prospective, Single-Center Study of 108 Consecutive Patients  

SciTech Connect

Purpose: To present the results of stereotactic body radiotherapy (SBRT) for medically inoperable patients with Stage I non-small-cell lung cancer (NSCLC) and contrast outcomes in patients with and without a pathologic diagnosis. Methods and Materials: Between December 2004 and October 2008, 108 patients (114 tumors) underwent treatment according to the prospective research ethics board-approved SBRT protocols at our cancer center. Of the 108 patients, 88 (81.5%) had undergone pretreatment whole-body [18F]-fluorodeoxyglucose positron emission tomography/computed tomography. A pathologic diagnosis was unavailable for 33 (28.9%) of the 114 lesions. The SBRT schedules included 48 Gy in 4 fractions or 54-60 Gy in 3 fractions for peripheral lesions and 50-60 Gy in 8-10 fractions for central lesions. Toxicity and radiologic response were assessed at the 3-6-month follow-up visits using conventional criteria. Results: The mean tumor diameter was 2.4-cm (range, 0.9-5.7). The median follow-up was 19.1 months (range, 1-55.7). The estimated local control rate at 1 and 4 years was 92% (95% confidence interval [CI], 86-97%) and 89% (95% CI, 81-96%). The cause-specific survival rate at 1 and 4 years was 92% (95% CI, 87-98%) and 77% (95% CI, 64-89%), respectively. No statistically significant difference was found in the local, regional, and distant control between patients with and without pathologically confirmed NSCLC. The most common acute toxicity was Grade 1 or 2 fatigue (53 of 108 patients). No toxicities of Grade 4 or greater were identified. Conclusions: Lung SBRT for early-stage NSCLC resulted in excellent local control and cause-specific survival with minimal toxicity. The disease-specific outcomes were comparable for patients with and without a pathologic diagnosis. SBRT can be considered an option for selected patients with proven or presumed early-stage NSCLC.

Taremi, Mojgan, E-mail: mojgan.taremi@rmp.uhn.on.ca [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada); Department of Radiation Oncology, University Health Network, Toronto, ON (Canada); Department of Radiation Oncology, VU University Medical Center, Amsterdam (Netherlands); Hope, Andrew [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada); Department of Radiation Oncology, University Health Network, Toronto, ON (Canada); Dahele, Max [Department of Radiation Oncology, Stronach Regional Cancer Center, Newmarket, ON (Canada); Pearson, Shannon [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada); Fung, Sharon [Department of Biostatistics, Princess Margaret Hospital, Toronto, ON (Canada); Purdie, Thomas [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada); Brade, Anthony [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada); Department of Radiation Oncology, University Health Network, Toronto, ON (Canada); Department of Radiation Oncology, VU University Medical Center, Amsterdam (Netherlands); Cho, John; Sun, Alexander; Bissonnette, Jean-Pierre; Bezjak, Andrea [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada); Department of Radiation Oncology, University Health Network, Toronto, ON (Canada)

2012-02-01T23:59:59.000Z

455

Isotoxic Dose Escalation in the Treatment of Lung Cancer by Means of Heterogeneous Dose Distributions in the Presence of Respiratory Motion  

Science Conference Proceedings (OSTI)

Purpose: To test, in the presence of intrafractional respiration movement, a margin recipe valid for a homogeneous and conformal dose distribution and to test whether the use of smaller margins combined with heterogeneous dose distributions allows an isotoxic dose escalation when respiratory motion is considered. Methods and Materials: Twenty-three Stage II-III non-small-cell lung cancer patients underwent four-dimensional computed tomography scanning. The gross tumor volume and clinical target volume (CTV) were outlined in the mid-ventilation phase. The CTV-to-planning target volume (PTV) margin was calculated by use of a standard margin recipe and the patient-specific respiration pattern. Standard three-dimensional treatment plans were generated and recalculated on the remaining respiration phases. The planning was repeated for a CTV-to-PTV margin decreased by 2.5 and 5 mm relative to the initial margin in all directions. Time-averaged dose-volume histograms (four-dimensional dose-volume histograms) were calculated to evaluate the CTV-to-PTV margin. Finally, the dose was escalated in the plans with decreased PTV such that the mean lung dose (predictor of radiation-induced pneumonitis) was equal to mean lung dose in the plan by use of the initially calculated margin. Results: A reduction of the standard margin by 2.5 mm compared with the recipe resulted in too low of a minimum dose for some patients. A combination of dose escalation and use of heterogeneous dose distribution was able to increase the minimum dose to the target by approximately 10% and 20% for a CTV-to-PTV margin reduction of 2.5 mm and 5.0 mm, respectively. Conclusion: The margin recipe is valid for intrafractional respiration-induced tumor motions. It is possible to increase the dose to the target without increased mean lung dose with an inhomogeneous dose distribution.

Baker, Mariwan; Nielsen, Morten [Laboratory of Radiation Physics, Odense University Hospital, Odense (Denmark); Hansen, Olfred [Department of Oncology, Odense University Hospital, Odense (Denmark); Jahn, Jonas Westberg [Laboratory of Radiation Physics, Odense University Hospital, Odense (Denmark); Korreman, Stine [Department of Radiation Oncology, Copenhagen University Hospital, Copenhagen (Denmark); Brink, Carsten, E-mail: carsten.brink@ouh.regionsyddanmark.dk [Laboratory of Radiation Physics, Odense University Hospital, Odense (Denmark); Institute of Clinical Research, University of Southern Denmark, Odense (Denmark)

2011-11-01T23:59:59.000Z

456

Surgical Management of Early-Stage Non-small Cell Lung Carcinoma and the Present and Future Roles of Adjuvant Therapy: A Review for the Radiation Oncologist  

Science Conference Proceedings (OSTI)

We review the evidence for optimal surgical management and adjuvant therapy for patients with stages I and II non-small cell lung cancer (NSCLC) along with factors associated with increased risks of recurrence. Based on the current evidence, we recommend optimal use of mediastinal lymph node dissection, adjuvant chemotherapy, and post-operative radiation therapy, and make suggestions for areas to explore in future prospective randomized clinical trials.

Medford-Davis, Laura [Department of Emergency Medicine, Ben Taub General Hospital, Houston, TX (United States)] [Department of Emergency Medicine, Ben Taub General Hospital, Houston, TX (United States); DeCamp, Malcom [Division of Thoracic Surgery, Department of Surgery, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois (United States)] [Division of Thoracic Surgery, Department of Surgery, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois (United States); Recht, Abram [Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (United States)] [Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (United States); Flickinger, John [Department of Radiation Oncology, Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (United States)] [Department of Radiation Oncology, Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (United States); Belani, Chandra P. [Department of Medical Oncology, Penn State Hershey Cancer Institute, Hershey, Pennsylvania (United States)] [Department of Medical Oncology, Penn State Hershey Cancer Institute, Hershey, Pennsylvania (United States); Varlotto, John, E-mail: jvarlotto@hmc.psu.edu [Division of Radiation Oncology, Penn State Hershey Cancer Institute, Hershey, Pennsylvania (United States)] [Division of Radiation Oncology, Penn State Hershey Cancer Institute, Hershey, Pennsylvania (United States)

2012-12-01T23:59:59.000Z

457

Maximum-Intensity Volumes for Fast Contouring of Lung Tumors Including Respiratory Motion in 4DCT Planning  

Science Conference Proceedings (OSTI)

Purpose: To assess the accuracy of maximum-intensity volumes (MIV) for fast contouring of lung tumors including respiratory motion. Methods and Materials: Four-dimensional computed tomography (4DCT) data of 10 patients were acquired. Maximum-intensity volumes were constructed by assigning the maximum Hounsfield unit in all CT volumes per geometric voxel to a new, synthetic volume. Gross tumor volumes (GTVs) were contoured on all CT volumes, and their union was constructed. The GTV with all its respiratory motion was contoured on the MIV as well. Union GTVs and GTVs including motion were compared visually. Furthermore, planning target volumes (PTVs) were constructed for the union of GTVs and the GTV on MIV. These PTVs were compared by centroid position, volume, geometric extent, and surface distance. Results: Visual comparison of GTVs demonstrated failure of the MIV technique for 5 of 10 patients. For adequate GTV{sub MIV}s, differences between PTVs were <1.0 mm in centroid position, 5% in volume, {+-}5 mm in geometric extent, and {+-}0.5 {+-} 2.0 mm in surface distance. These values represent the uncertainties for successful MIV contouring. Conclusion: Maximum-intensity volumes are a good first estimate for target volume definition including respiratory motion. However, it seems mandatory to validate each individual MIV by overlaying it on a movie loop displaying the 4DCT data and editing it for possible inadequate coverage of GTVs on additional 4DCT motion states.

Rietzel, Eike [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Abteilung Biophysik, Gesellschaft fuer Schwerionenforschung, Darmstadt (Germany)], E-mail: eike@rietzel.net; Liu, Arthur K.; Chen, George T.Y.; Choi, Noah C. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States)

2008-07-15T23:59:59.000Z