Powered by Deep Web Technologies
Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Lung cancer Lung cancer Lung cancer Lung c  

E-Print Network [OSTI]

--22000000 34 Lung cancer Lung cancer Lung cancer Lung c ancer Lung cancer Lung cancer Lung cancer L ung cancer Lung cancer Lung cancer Lung can cer Lung cancer Lung cancer Lung cancer Lun g cancer Lung cancer Lung cancer Lung cance r Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer

Paxton, Anthony T.

2

Whole-Genome Sequencing of Asian Lung Cancers: Second-Hand Smoke Unlikely to Be Responsible for Higher Incidence of Lung Cancer among Asian Never-Smokers  

Science Journals Connector (OSTI)

...994-1007. 11. Zhao Y , Wang S, Aunan K, Seip HM Hao J.Air pollution and lung cancer risks in China-a meta-analysis...Goldberg MS, Gao YT Jin F.Lung cancer and indoor air pollution arising from Chinese-style cooking among nonsmoking...

Vidhya G. Krishnan; Philip J. Ebert; Jason C. Ting; Elaine Lim; Swee-Seong Wong; Audrey S.M. Teo; Yong G. Yue; Hui-Hoon Chua; Xiwen Ma; Gary S.L. Loh; Yuhao Lin; Joanna H.J. Tan; Kun Yu; Shenli Zhang; Christoph Reinhard; Daniel S.W. Tan; Brock A. Peters; Stephen E. Lincoln; Dennis G. Ballinger; Jason M. Laramie; Geoffrey B. Nilsen; Thomas D. Barber; Patrick Tan; Axel M. Hillmer; and Pauline C. Ng

2014-11-01T23:59:59.000Z

3

Lung Cancer Incidence Trends by Histology Type among Asian American, Native Hawaiian, and Pacific Islander Populations in the United States, 1990–2010  

Science Journals Connector (OSTI)

...Devesa SS.Lung cancer trends by histologic type cancer. 2014, in press. 16. Surveillance Epidemiology and End Results web site, http://seer.cancer.gov/ . SEER Registries. [internet]. [accessed May 2010]. Available from: http...

Iona Cheng; Gem M. Le; Anne-Michelle Noone; Kathleen Gali; Manali Patel; Robert W. Haile; Heather A. Wakelee; Scarlett L. Gomez

2014-11-01T23:59:59.000Z

4

QUESTIONS & ANSWERS ABOUT LUNG CANCER  

E-Print Network [OSTI]

QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

5

Lung Cancer Screening and clinical implications.  

E-Print Network [OSTI]

??abstractLung cancer is the most frequently diagnosed major cancer worldwide and the leading cause of death from cancer. Lung cancer is divided into two subgroups:… (more)

S.C. van 't Westeinde (Susan)

2012-01-01T23:59:59.000Z

6

Early Lung Cancer Detection Program  

Broader source: Energy.gov [DOE]

Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

7

AmericanLungAssociationStateofLungDiseaseinDiverseCommunities2010 55 Lung Cancer  

E-Print Network [OSTI]

AmericanLungAssociationStateofLungDiseaseinDiverseCommunities2010 55 Lung Cancer Lung cancer of cancer cells (tumors) then form and grow . Besides interfering with how the lung functions, cancer cells organs . Causes Cigarette smoking is by far the most important cause of lung cancer, and the risk from

Kaski, Samuel

8

Does living near heavy industry cause lung cancer in women? A case control study using life grid interviews.   

E-Print Network [OSTI]

of a modestly raised risk of lung cancer with prolonged residence close to heavy industry, although the confidence intervals were wide. The effect of air pollution on the incidence of lung cancer merits continued study....

Edwards, R; Pless-Mulloli, T; Howel, D; Chadwick, TJ; Bhopal, Raj; Harrison, R N; Gribbin, H

2006-10-13T23:59:59.000Z

9

Lung Cancer Assistant: a hybrid clinical decision support application for lung cancer care  

Science Journals Connector (OSTI)

...author and source are credited. Lung Cancer Assistant: a hybrid clinical decision support application for lung cancer care M. Berkan Sesen 1 Michael D...meetings are becoming the model of care for cancer patients worldwide. While MDTs have...

2014-01-01T23:59:59.000Z

10

Eur J Cancer. Author manuscript Social inequalities in cancer incidence and cancer survival: Lessons from  

E-Print Network [OSTI]

Eur J Cancer. Author manuscript Page /1 5 Social inequalities in cancer incidence and cancer ( ). With regards to cancer risk, a first comprehensive review of socioeconomic inequalities was1 published by IARC in 1997 ( ). This review covered inequalities in cancer mortality, incidence and survival and discussed

Paris-Sud XI, Université de

11

A Risk Model for Lung Cancer Incidence  

Science Journals Connector (OSTI)

...University Medical Center, Utrecht, The Netherlands; 17 Institute...810-0.875), the Bach model applied to the same data gave an AUC...the Netherlands (Bilthoven, Utrecht), Greece, Germany (Potsdam...only smoking information. We applied these models to the test set...

Clive Hoggart; Paul Brennan; Anne Tjonneland; Ulla Vogel; Kim Overvad; Jane Nautrup Østergaard; Rudolf Kaaks; Federico Canzian; Heiner Boeing; Annika Steffen; Antonia Trichopoulou; Christina Bamia; Dimitrios Trichopoulos; Mattias Johansson; Domenico Palli; Vittorio Krogh; Rosario Tumino; Carlotta Sacerdote; Salvatore Panico; Hendriek Boshuizen; H. Bas Bueno-de-Mesquita; Petra H.M. Peeters; Eiliv Lund; Inger Torhild Gram; Tonje Braaten; Laudina Rodríguez; Antonio Agudo; Emilio Sánchez-Cantalejo; Larraitz Arriola; Maria-Dolores Chirlaque; Aurelio Barricarte; Torgny Rasmuson; Kay-Tee Khaw; Nicholas Wareham; Naomi E. Allen; Elio Riboli; and Paolo Vineis

2012-06-01T23:59:59.000Z

12

Abstract B17: Health disparities in brain cancer incidence  

Science Journals Connector (OSTI)

...GA Abstract B17: Health disparities in brain cancer incidence Emanuela Taioli 1 Wenqi...reported that US black patients have lower brain cancer rates than whites, and this has...Gregory J. Riggins. Health disparities in brain cancer incidence. [abstract]. In...

Emanuela Taioli; Wenqi Gan; Gregory J. Riggins

2014-11-01T23:59:59.000Z

13

Smoking and Lung Cancer: An Overview  

Science Journals Connector (OSTI)

...show markedly increased risks of lung cancer in smokers...Net Cost In the contemporary political and economic environment...cigarette smoking. The other is a political motivation. Proponents of...viewed as any other business investment, where the financial bottom...

Lawrence A. Loeb; Virginia L. Emster; Kenneth E. Warner; John Abbotts; and John Laszlo

1984-12-01T23:59:59.000Z

14

Smoking and Lung Cancer: An Overview  

Science Journals Connector (OSTI)

...show markedly increased risks of lung cancer in smokers...personalizing" the economic risk of smoking. The study...their totals, since life insurance will "defray" some...in the costs of health insurance should be a fairly straight...Cost In the contemporary political and economic environment...

Lawrence A. Loeb; Virginia L. Emster; Kenneth E. Warner; John Abbotts; and John Laszlo

1984-12-01T23:59:59.000Z

15

Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention  

E-Print Network [OSTI]

of lung cancer,” Clinical Cancer Research, vol. 4, no. 7,pathogenesis of lung cancer,” Annual Review of Physiology,immunoreac- tivity in lung cancer: yet another player in the

2012-01-01T23:59:59.000Z

16

Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy  

E-Print Network [OSTI]

Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

Smith, Elizabeth Brooks

2009-05-15T23:59:59.000Z

17

Vitamin D and Cancer Incidence—Response to Grant  

Science Journals Connector (OSTI)

...September 2014 letter Letters to the Editor Vitamin D and Cancer Incidence-Letter from Grant William B. Grant * * Corresponding Author: William B. Grant, Sunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco...

Tea Skaaby; Lise Lotte Nystrup Husemoen; Allan Linneberg

2014-09-01T23:59:59.000Z

18

Former Worker Program - Early Lung Cancer Detection Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Former Worker Program (FWP) Former Worker Program (FWP) Home Covered Sites/Populations › Construction Worker Screening Projects › Production Worker Screening Projects › Supplemental Screening Program › Beryllium Vendor Screening Program Upcoming Events Program Implementation Outreach Medical Screening - Conventional Medical Screening - Early Lung Cancer Detection Communicating Results Protecting Participant Information Sharing De-identified Data Chronic Beryllium Disease Awareness Joint Outreach Task Group (JOTG) Worker Testimonials Contact Us FWP Scientific Publications FWP Documents Related Links Office of Health and Safety Home Page HSS Logo Early Lung Cancer Detection Program Former Worker Medical Screening Program (FWP) Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer. Through the FWP, DOE initiated the Early Lung Cancer Detection (ELCD) program using low-dose helical CT scans to detect lung cancers at an earlier, more treatable stage. Lung cancer results in about 160,000 deaths in the U.S. every year. The most common causes of lung cancer are long-term exposures to tobacco smoke and residential radon emissions, but occupational hazards, such as asbestos and ionizing radiation, also cause or contribute to the disease.

19

The Cytokinesis-Blocked Micronucleus Assay as a Strong Predictor of Lung Cancer: Extension of a Lung Cancer Risk Prediction Model  

Science Journals Connector (OSTI)

...independent external lung cancer population and test discriminatory power improvement of the...506 participants were stratified into a test set of 995 (527 cases/468 controls...independent lung cancer population and test the effect of extending an existing lung...

Randa A. El-Zein; Mirtha S. Lopez; Anthony M. D'Amelio, Jr; Mei Liu; Reginald F. Munden; David Christiani; Li Su; Paula Tejera-Alveraz; Rihong Zhai; Margaret R. Spitz; Carol J. Etzel

2014-11-01T23:59:59.000Z

20

Treatment outcomes using CyberKnife for brain metastases from lung cancer  

Science Journals Connector (OSTI)

......Treatment outcomes using CyberKnife for brain metastases from lung cancer Keisuke Tamari...fractionated stereotactic radiotherapy (SRT) for brain metastases from lung cancer. A total of 67 patients with 109 brain metastases from lung cancer treated using......

Keisuke Tamari; Osamu Suzuki; Naoya Hashimoto; Naoki Kagawa; Masateru Fujiwara; Iori Sumida; Yuji Seo; Fumiaki Isohashi; Yasuo Yoshioka; Toshiki Yoshimine; Kazuhiko Ogawa

2014-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Lung Cancer and Arsenic Concentrations in Drinking Water in Chile  

E-Print Network [OSTI]

cancer risks was found in a small cohort study in Japan involving residents using well water con concentrations in water sources piped to households. It is the first large, popula- tion-based lung cancer case

California at Berkeley, University of

22

E-Print Network 3.0 - asbestos-related lung cancer Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the level of risk for lung and other cancers. Methods We performed a meta... household coal use and lung cancer risk, and to explore ... Source: Collection: Environmental...

23

Investigating the initiation and progression of small cell lung cancer  

E-Print Network [OSTI]

Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. ...

Brauneis, Alison Dooley

2011-01-01T23:59:59.000Z

24

lung cancer smoke-free 6 One man's  

E-Print Network [OSTI]

Fighting lung cancer Living smoke-free 6 One man's mission85 #12;Cure is the newsletter for the University of Florida Shands Cancer Center, home to cancer care and research for the Southeast's most? For more information about care and services offered at the UF Shands Cancer Center, call 352

Roy, Subrata

25

A Bayesian analysis of uncertainties on lung doses resulting from occupational exposures to uranium  

Science Journals Connector (OSTI)

......lung dose and lung cancer incidence resulting...occupational exposures to uranium. These calculations...from inhalation of uranium ignore significant...estimates of lung cancer are based on PEs...from inhalation of depleted uranium. Health Phys......

M. Puncher; A. Birchall; R. K. Bull

2013-09-01T23:59:59.000Z

26

Thyroid cancer incidence in relation to volcanic activity  

SciTech Connect (OSTI)

Environmental or genetic factors are sought to explain the high incidence of thyroid cancer in Iceland. At present, it is impossible to cite any environmental factor, particularly one related to the volcanic activity in the country, which could explain the high incidence of thyroid cancer in Iceland. However, the thyroid gland in Icelanders is very small due to the high intake of iodine from seafood. It is, therefore, easier for physicians to find thyroid tumors. Furthermore, genetic factors are very likely to be of great importance in the small, isolated island of Iceland.

Arnbjoernsson, E.A.; Arnbjoernsson, A.O.; Olafsson, A.

1986-01-01T23:59:59.000Z

27

MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells  

E-Print Network [OSTI]

imaging; theranostic nanomedicine; doxorubicin; Rv 6 integrin; superparamagnetic iron oxide; lung cancer

Gao, Jinming

28

Cancer incidence in areas with elevated levels of natural radiation  

Science Journals Connector (OSTI)

It has been reported that on reaching a certain level of cell damage the production of repair enzymes is triggered which decreases the chromosome aberrations. If this happens, prolonged exposure to high levels of natural radiation in areas with elevated levels of background radiation could decrease the frequency of chromosome aberrations. Recent epidemiological studies indicated that there is an increased risk of cancer in healthy individuals with high levels of chromosomal aberrations. Studies performed in Nordic countries as well as Italy, showed that increased levels of chromosome aberrations in lymphocytes can be used to predict cancer risk in humans. One may conclude that a dose of ionising radiation sufficient to produce a certain level of cell damage increases production of antioxidants and repair enzymes that decrease either the frequency of chromosome aberrations or the cancer risk. People in some areas of Ramsar, a city in northern Iran, receive an annual radiation dose from background radiation that is more than five times higher than the 20 mSv. Yr-1 that is permitted for radiation workers. Inhabitants of Ramsar have lived for many generations in these high background areas. If an annual radiation dose of a few hundred mSv is detrimental to health, causing genetic abnormalities or an increased risk of cancer, it should be evident in these people. The absorbed dose rate in some high background radiation areas of Ramsar is approximately 55-200 times higher than that of the average global dose rate. It has been reported that 3â??8% of all cancers are caused by current levels of ionising radiation. If this estimation were true, all the inhabitants of such an area with extraordinary elevated levels of natural radiation would have died of cancer. Our cytogenetic studies show no significant differences between people in the high background area compared to people in normal background areas. As there was no increased level of chromosome aberrations, it may be predicted that the cancer incidence is not higher than in the neighbouring areas with a normal background radiation level. Although there is not yet solid epidemiological information, most local physicians in Ramsar report anecdotally that there is no increase in the incidence rates of cancer or leukemia in their area. There are no data to indicate a significant increase of cancer incidence in other high background radiation areas (HBRAs). Furthermore, several studies show a significant decrease of cancer death rates in areas with high backgrounds. It can be concluded that prolonged exposure to high levels of natural radiation possibly triggers processes such as the production of antioxidants and repair enzymes, which decreases the frequency of chromosome aberrations and the cancer incidence rate.

S.M.J. Mortazavi; M. Ghiassi-Nejad; P.A. Karam; T. Ikushima; A. Niroomand-Rad; J.R. Cameron

2006-01-01T23:59:59.000Z

29

Lung cancer epidemiology in New Mexico uranium miners  

SciTech Connect (OSTI)

This investigation assesses the health effects of radon progeny exposure in New Mexico uranium miners. Cumulative exposures sustained by most New Mexico miners are well below those received earlier in the Colorado Plateau. This project utilizes the research opportunity offered by New Mexico miners to address unresolved issues related to radon progeny exposure: (1) the lung cancer risk of lower levels of exposure, (2) interaction between radon progeny exposure and cigarette smoking in the causation of lung cancer, (3) the relationship between lung cancer histologic type and radon progeny exposure, and (4) possible effects of radon progeny exposure other than lung cancer. A cohort study of 3800 men with at least one year of underground uranium mining experience in New Mexico is in progress. Results are discussed.

Samet, J.M.

1991-11-01T23:59:59.000Z

30

Second cancer incidence risk estimates using BEIR VII models for standard and complex external beam radiotherapy for early breast cancer  

SciTech Connect (OSTI)

Purpose: To compare organ specific cancer incidence risks for standard and complex external beam radiotherapy (including cone beam CT verification) following breast conservation surgery for early breast cancer.Method: Doses from breast radiotherapy and kilovoltage cone beam CT (CBCT) exposures were obtained from thermoluminescent dosimeter measurements in an anthropomorphic phantom in which the positions of radiosensitive organs were delineated. Five treatment deliveries were investigated: (i) conventional tangential field whole breast radiotherapy (WBRT), (ii) noncoplanar conformal delivery applicable to accelerated partial beast irradiation (APBI), (iii) two-volume simultaneous integrated boost (SIB) treatment, (iv) forward planned three-volume SIB, and (v) inverse-planned three volume SIB. Conformal and intensity modulated radiotherapy methods were used to plan the complex treatments. Techniques spanned the range from simple methods appropriate for patient cohorts with a low cancer recurrence risk to complex plans relevant to cohorts with high recurrence risk. Delineated organs at risk included brain, salivary glands, thyroid, contralateral breast, left and right lung, esophagus, stomach, liver, colon, and bladder. Biological Effects of Ionizing Radiation (BEIR) VII cancer incidence models were applied to the measured mean organ doses to determine lifetime attributable risk (LAR) for ages at exposure from 35 to 80 yr according to radiotherapy techniques, and included dose from the CBCT imaging. Results: All LAR decreased with age at exposure and were lowest for brain, thyroid, liver, and bladder (<0.1%). There was little dependence of LAR on radiotherapy technique for these organs and for colon and stomach. LAR values for the lungs for the three SIB techniques were two to three times those from WBRT and APBI. Uncertainties in the LAR models outweigh any differences in lung LAR between the SIB methods. Constraints in the planning of the SIB methods ensured that contralateral breast doses and LAR were comparable to WBRT, despite their added complexity. The smaller irradiated volume of the ABPI plan contributed to a halving of LAR for contralateral breast compared with the other plan types. Daily image guided radiotherapy (IGRT) for a left breast protocol using kilovoltage CBCT contributed <10% to LAR for the majority of organs, and did not exceed 22% of total organ dose. Conclusions: Phantom measurements and calculations of LAR from the BEIR VII models predict that complex breast radiotherapy techniques do not increase the theoretical risk of second cancer incidence for organs distant from the treated breast, or the contralateral breast where appropriate plan constraints are applied. Complex SIB treatments are predicted to increase the risk of second cancer incidence in the lungs compared to standard whole breast radiotherapy; this is outweighed by the threefold reduction in 5 yr local recurrence risk for patients of high risk of recurrence, and young age, from the use of radiotherapy. APBI may have a favorable impact on risk of second cancer in the contralateral breast and lung for older patients at low risk of recurrence. Intensive use of IGRTincreased the estimated values of LAR but these are dominated by the effect of the dose from the radiotherapy, and any increase in LAR from IGRT is much lower than the models' uncertainties.

Donovan, E. M.; James, H.; Bonora, M.; Yarnold, J. R.; Evans, P. M. [Joint Department of Physics, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton SM2 5PT (United Kingdom); Physics Department, Ipswich Hospital NHS Foundation Trust, Ipswich IP4 5PD (United Kingdom); Department of Academic Radiotherapy, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton SM2 5PT, United Kingdom and School of Radiotherapy, University of Milan, Milan 20122 (Italy); Department of Academic Radiotherapy, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton SM2 5PT (United Kingdom); Centre for Vision Speech and Signal Processing, University of Surrey, Guildford GU2 7XH (United Kingdom)

2012-10-15T23:59:59.000Z

31

Pap test use and cervical cancer incidence in First Nations women living in Manitoba  

Science Journals Connector (OSTI)

...special-property>author-choice Pap test use and cervical cancer incidence in First Nations...Sciences, University of Manitoba This study examined Pap test utilization, Pap test results, and cervical cancer incidence among First...

Kathleen M. Decker; Alain A. Demers; Erich V. Kliewer; Natalie Biswanger; Grace Musto; Brenda Elias; Jane Griffith; Donna Turner

32

Lung cancer mortality is elevated in coal-mining areas of Appalachia  

Science Journals Connector (OSTI)

Summary Previous research has documented increased lung cancer incidence and mortality in Appalachia. The current study tests whether residence in coal-mining areas of Appalachia is a contributing factor. We conducted a national county-level analysis to identify contributions of smoking rates, socioeconomic variables, coal-mining intensity and other variables to age-adjusted lung cancer mortality. Results demonstrate that lung cancer mortality for the years 2000–2004 is higher in areas of heavy Appalachian coal mining after adjustments for smoking, poverty, education, age, sex, race and other covariates. Higher mortality may be the result of exposure to environmental contaminates associated with the coal-mining industry, although smoking and poverty are also contributing factors. The knowledge of the geographic areas within Appalachia where lung cancer mortality is higher can be used to target programmatic and policy interventions. The set of socioeconomic and health inequalities characteristic of coal-mining areas of Appalachia highlights the need to develop more diverse, alternative local economies.

Michael Hendryx; Kathryn O’Donnell; Kimberly Horn

2008-01-01T23:59:59.000Z

33

Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and  

E-Print Network [OSTI]

Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and geographic We have previously shown that geographic differences in cancer mortalities in Europe are related of 45 male and 47 female cancers. Differences in cancer incidences are correlated moder- ately, first

Rosenberg, Michael S.

34

Cancer Incidence in First Generation U.S. Hispanics: Cubans, Mexicans, Puerto Ricans, and New Latinos  

Science Journals Connector (OSTI)

2009 American Association for Cancer Research. August 2009 research-article Research Articles Cancer Incidence in First Generation U.S. Hispanics...for reprints: Paulo S. Pinheiro, Florida Cancer Data System, University of Miami School...

Paulo S. Pinheiro; Recinda L. Sherman; Edward J. Trapido; Lora E. Fleming; Youjie Huang; Orlando Gomez-Marin; David Lee

2009-08-01T23:59:59.000Z

35

A study of the relationship between emotional history and the incidence of cancer in human subjects  

E-Print Network [OSTI]

SUBJECTS' CRITICAL INCIDENTS 55 APPENDIX D - SUMMARIES OF NON-CANCER 72 SUBJECTS' CRITICAL INCIDENTS APPENDIX E - RELEASE FORM 87 VITA 89 LIST OF TABLES Table Page B iographical Data of Sub j ects in Sample 10 Statistical Analysis of Data 22... Number of Critical Incidents and Final Evaluations in Non-Cancer Subjects 23 Number of Critical Incidents and Final Evaluations in Cancer Subjects 24 LIST OF FIGURES Figure Page Emotionality Rating Scale 20 Relation between Ego Defenses, Level...

Sebastian, Henry Andrew

1972-01-01T23:59:59.000Z

36

E-Print Network 3.0 - a549 lung cancer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and lung cancer: systematic review and meta-analysis of casecontrol Summary: Household coal use and lung cancer: systematic review and meta-analysis of case-control studies... ,...

37

A filter-based feature selection approach for identifying potential biomarkers for lung cancer  

E-Print Network [OSTI]

Background: Lung cancer is the leading cause of death from cancer in the world and its treatment is dependant on the type and stage of cancer detected in the patient. Molecular biomarkers that can characterize the cancer ...

Lee, In-Hee; Lushington, Gerald H.; Visvanathan, Mahesh

2011-03-21T23:59:59.000Z

38

E-Print Network 3.0 - advanced lung cancer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: advanced lung cancer Page: << < 1 2 3 4 5 > >> 1 aallll IIrreell aanndd ccaanncceerr...

39

Alcohol Consumption and Lung Cancer: A Review of the Epidemiologic Evidence  

Science Journals Connector (OSTI)

...particularly beer intake may increase lung cancer risk after...has been suggested to increase lung cancer risk in a...that alcohol intake may increase lung cancer risk (3...criteria to assess the quality of the studies were assessment...usual consumption of wine (including Japanese...

Elisa V. Bandera; Jo L. Freudenheim; and John E. Vena

2001-08-01T23:59:59.000Z

40

E-Print Network 3.0 - annual cancer incidence Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Powered by Explorit Topic List Advanced Search Sample search results for: annual cancer incidence Page: << < 1 2 3 4 5 > >> 1 aallll IIrreell aanndd ccaanncceerr...

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Differential Molecular Changes in the Lung after Low and High Carcinogen  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Differential Molecular Changes in the Lung after Low and High Carcinogen Differential Molecular Changes in the Lung after Low and High Carcinogen Doses and Implications for Designing Molecular Epidemiology and other Studies of Radiation-Induced Lung Cancer Bobby R. Scott Lovelace Respiratory Research Institute Abstract Lung Cancer Mortality Worldwide by Gender: Lung cancer was the most commonly diagnosed cancer worldwide as well as the leading cause of cancer death in males in 2008 (Jemal et al. 2011). For females, it was the fourth most commonly diagnosed cancer and the second leading cause of cancer death. Lung cancer accounted for 13% of the total cases and 18% of the cancer deaths. For males, the highest lung cancer incidence rates are in Central and Eastern Europe, Southern Europe, and Northern America. For females, the highest lung cancer incidence rates are in Northern America,

42

GSTM1 and CYP1A1 polymorphisms, tobacco, air pollution, and lung cancer: a study in rural Thailand  

SciTech Connect (OSTI)

Incidence rates of lung cancer is high in Lampang Province in northern Thailand, particularly in women. This study was conducted to quantify the risk of lung cancer associated with exposures prevalent in the area and to investigate possible interactions with genetic susceptibility. The presence of several large open-cast coal mines from 1955 close to electricity-generating plants was a particular focus of concern. A point source air pollution exposure index was calculated for each village/ township reported in residential histories based on the linear distance from the Mae Moh Center (the area of the electricity-generating plants), the year-specific gaseous (SO{sub 2} and NO{sub 2}) or total suspended particulate emissions from the Mae Moh Power Plant, and the percentage of wind from the center. Odds ratios for the disease associated with categorical variables were estimated within unconditional logistic regression. Extraction of genomic DNA and genotyping of variants in CYP1A1 and GSTM1 were conducted to assess the extent of modification of risk by these genes that are involved in the metabolism of polycyclic aromatic hydrocarbons. Smoking of local high tar unfiltered products is commonamongst women. None of the three polymorphisms examined increased the risk of lung cancer or modified the risk associated with smoking. 96% of male and 64% of female lung cancer incidence were explained by tobacco smoking. None of the potential sources of air pollution deriving from the combustion of coal and wood, or polymorphisms in the CYP1A1 gene or deletion of the GSTM1 had an effect on the risk of lung cancer, either together or separately.

Pisani, P.; Srivatanakul, P.; Randerson-Moor, J.; Vipasrinimit, S.; Lalitwongsa, S.; Unpunyo, P.; Bashir, S.; Bishop, D.T.

2006-04-15T23:59:59.000Z

43

Low-Dose Spiral CT Scans for Early Lung Cancer Detection | Department of  

Broader source: Energy.gov (indexed) [DOE]

Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-dose spiral computed tomography (CT) scanning is a noninvasive medical imaging test that has been used for the early detection of lung cancer for over 16 years (Sone et al. 1998; Henschke et.al. 1999). A low-dose spiral chest CT differs from a full-dose conventional chest CT scan primarily in the amount of radiation emitted during CT scans. Chest CT, in general, requires less radiation exposure than other CT procedures because the air-filled tissues of the lungs are not as dense as the tissues of other organs (i.e., less x-ray radiation is needed to penetrate the lung). Radiation dose can be further reduced with lung cancer screening due to the

44

E-Print Network 3.0 - assessing lung cancer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

- Department of Genetics, Yale University Collection: Biology and Medicine 20 Household coal use and lung cancer: systematic review and meta-analysis of casecontrol Summary:...

45

The shape of the hazard function for cancer incidence  

Science Journals Connector (OSTI)

A population-based cohort consisting of 126,141 men and 122,208 women born between 1874 and 1931 and at risk for breast or colorectal cancer after 1965 was identified by linking the Utah Population Data Base and the Utah Cancer Registry. The hazard function ... Keywords: Breast cancer, Colorectal cancer, Hazard function, Survival analysis, Truncation

K. M. Boucher; R. A. Kerber

2001-06-01T23:59:59.000Z

46

Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease  

Science Journals Connector (OSTI)

...fitters, steamfitters, shipyard boilermakers, nonshipyard boilermakers, shipyard electricians, ship scalers, insulators, plasterboard workers, or sheet-metal workers — for 5 years. The asbestos pilot study had no requirements regarding smoking; subsequently, subjects were required to be current smokers... Lung cancer is the leading cause of death from cancer in the United States, accounting for approximately 29 percent of deaths from cancer and 6 percent of all deaths.1 New approaches are essential to prevent lung cancer in persons who have smoked ...

Omenn G.S.; Goodman G.E.; Thornquist M.D.

1996-05-02T23:59:59.000Z

47

Lung-Cancer Screening with Low-Dose Computed Tomography  

Science Journals Connector (OSTI)

...but complications of invasive testing were not. Across all three rounds of screening, 39% of the participants in the low-dose CT group had at least one positive result; more than 95% of these findings were falsely positive. Most patients with positive screening-test results required follow-up imaging... A large randomized trial showed that low-dose CT screening reduced the risk of lung-cancer death by 20% among long-time smokers. Recent guidelines support consideration of screening but with attention to the possibility of false positive results and associated risks.

Gould M.K.

2014-11-06T23:59:59.000Z

48

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 49:709718 (2006) Smoking Imputation and Lung Cancer in  

E-Print Network [OSTI]

in Railroad Workers Exposed to Diesel Exhaust Eric Garshick, MD, MOH,1,2� Francine Laden, ScD,2,3 Jaime E relative risk of lung cancer in railroad workers exposed to diesel exhaust compared to unexposed workers. Med. 49:709­718, 2006. � 2006 Wiley-Liss, Inc. KEY WORDS: diesel exhaust; lung cancer; multiple

Reid, Nancy

49

Vitamin D and Cancer Incidence—Letter from Grant  

Science Journals Connector (OSTI)

...Urethan Impact of the National Cancer Act on grant support. | The National Cancer Act of...A major effect was the increase for the Grants Program from +93 million in fiscal year 1970 to more than +280 million in 1974. Grant programs, administered by the Division...

William B. Grant

2014-09-01T23:59:59.000Z

50

Expression of hPNAS-4 Radiosensitizes Lewis Lung Cancer  

SciTech Connect (OSTI)

Purpose: This study aimed to transfer the hPNAS-4 gene, a novel apoptosis-related human gene, into Lewis lung cancer (LL2) and observe its radiosensitive effect on radiation therapy in vitro and in vivo. Methods and Materials: The hPNAS-4 gene was transfected into LL2 cells, and its expression was detected via western blot. Colony formation assay and flow cytometry were used to detect the growth and apoptosis of cells treated with irradiation/PNAS-4 in vitro. The hPNAS-4 gene was transferred into LL2-bearing mice through tail vein injection of the liposome/gene complex. The tumor volumes were recorded after radiation therapy. Proliferating cell nuclear antigen (PCNA) immunohistochemistry staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were performed to detect the tumor cell growth and apoptosis in vivo. Results: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue, and its overexpressions were confirmed via western blot analysis. Compared with the control, empty plasmid, hPNAS-4, radiation, and empty plasmid plus radiation groups, the hPNAS-4 plus radiation group more significantly inhibited growth and enhanced apoptosis of LL2 cells in vitro and in vivo (P<.05). Conclusions: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue and was expressed in both LL2 cell and tumor tissue. The hPNAS-4 gene therapy significantly enhanced growth inhibition and apoptosis of LL2 tumor cells by radiation therapy in vitro and in vivo. Therefore, it may be a potential radiosensitive treatment of radiation therapy for lung cancer.

Zeng Hui [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Yuan Zhu [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Zhu Hong [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Lei; Shi Huashan [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Wang Zi; Fan Yu; Deng Qian; Zeng Jianshuang; He Yinbo [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Xiao Jianghong [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Zhiping, E-mail: lizhiping620312@yahoo.com.cn [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)

2012-11-15T23:59:59.000Z

51

Low-Dose Spiral CT Scans for Early Lung Cancer Detection  

Broader source: Energy.gov [DOE]

Low-dose spiral computed tomography (CT) scanning is a noninvasive medical imaging test that has been used for the early detection of lung cancer for over 16 years (Sone et al. 1998; Henschke et.al. 1999).

52

Lung cancer epidemiology in New Mexico uranium miners. Progress report, March 1, 1991--November 30, 1991  

SciTech Connect (OSTI)

This investigation assesses the health effects of radon progeny exposure in New Mexico uranium miners. Cumulative exposures sustained by most New Mexico miners are well below those received earlier in the Colorado Plateau. This project utilizes the research opportunity offered by New Mexico miners to address unresolved issues related to radon progeny exposure: (1) the lung cancer risk of lower levels of exposure, (2) interaction between radon progeny exposure and cigarette smoking in the causation of lung cancer, (3) the relationship between lung cancer histologic type and radon progeny exposure, and (4) possible effects of radon progeny exposure other than lung cancer. A cohort study of 3800 men with at least one year of underground uranium mining experience in New Mexico is in progress. Results are discussed.

Samet, J.M.

1991-11-01T23:59:59.000Z

53

Artificial Neural Network-Based Serum Biomarkers Analysis Improves Sensitivity in the Diagnosis of Lung Cancer  

Science Journals Connector (OSTI)

Lung cancer diagnosis in early stages could be of paramount interest since patients may be treated opportunely decreasing the high death rate caused by this disease. A biomarker may describe abnormalities in the ...

J. M. Flores; E. Herrera; G. Leal…

2013-01-01T23:59:59.000Z

54

Altered HOX and WNT7A expression in human lung cancer  

Science Journals Connector (OSTI)

Altered HOX and WNT7A expression in human lung cancer 10.1073/pnas.97.23.12776 Roser Calvo James West Wilbur Franklin Paul Erickson Lynne Bemis Efang Li Barbara Helfrich Paul Bunn Joelle Roche Elisabeth Brambilla...

Roser Calvo; James West; Wilbur Franklin; Paul Erickson; Lynne Bemis; Efang Li; Barbara Helfrich; Paul Bunn; Joelle Roche; Elisabeth Brambilla; Rafael Rosell; Robert M. Gemmill; Harry A. Drabkin

2000-01-01T23:59:59.000Z

55

Fisetin induces apoptosis in human nonsmall lung cancer cells via a mitochondria-mediated pathway  

Science Journals Connector (OSTI)

The present study investigated the apoptotic effects of fisetin, a phenolic compound, against the human ... cell lung cancer cell line, NCI-H460. Fisetin showed dose-dependent cytotoxic activity against NCI- ... ...

Kyoung Ah Kang; Mei Jing Piao; Jin Won Hyun

2014-11-01T23:59:59.000Z

56

Abstract 1238: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer  

Science Journals Connector (OSTI)

...LB-521: Expression profile of nuclear receptor superfamily in a lung...TX To explore the role of nuclear receptors in lung cancer pathogenesis...expression of the 48 human nuclear receptors (NRs) in a panel...progression. Overall, these datasets provide insight into clinical...

Yangsik Jeong; Woochang Lee; Yang Xie; Angie L. Bookout; Bong-hyun Kim; Luc Girard; John D. Minna; and David J. Mangelsdorf

2010-04-15T23:59:59.000Z

57

Associations between Beer, Wine, and Liquor Consumption and Lung Cancer Risk: A Meta-analysis  

Science Journals Connector (OSTI)

...literature on beer, wine, and liquor intake and...alcoholic beverage (beer, wine, or liquor) and lung...per bottle, 150 mL of wine per glass, and 40 mL...beverage could potentially increase the risk of lung cancer...alcoholic beverages, and quality of smoking adjustment...

Chun Chao

2007-11-01T23:59:59.000Z

58

Stereotactic Body Radiation Therapy for Patients With Lung Cancer Previously Treated With Thoracic Radiation  

SciTech Connect (OSTI)

Purpose: Stereotactic body radiation therapy (SBRT) provides excellent local control with acceptable toxicity for patients with early-stage non-small cell lung cancer. However, the efficacy and safety of SBRT for patients previously given thoracic radiation therapy is not known. In this study, we retrospectively reviewed outcomes after SBRT for recurrent disease among patients previously given radiation therapy to the chest. Materials and Methods: A search of medical records for patients treated with SBRT to the thorax after prior fractionated radiation therapy to the chest at The University of Texas M. D. Anderson Cancer Center revealed 36 such cases. The median follow-up time after SBRT was 15 months. The endpoints analyzed were overall survival, local control, and the incidence and severity of treatment-related toxicity. Results: SBRT provided in-field local control for 92% of patients; at 2 years, the actuarial overall survival rate was 59%, and the actuarial progression-free survival rate was 26%, with the primary site of failure being intrathoracic relapse. Fifty percent of patients experienced worsening of dyspnea after SBRT, with 19% requiring oxygen supplementation; 30% of patients experienced chest wall pain and 8% Grade 3 esophagitis. No Grade 4 or 5 toxic effects were noted. Conclusions: SBRT can provide excellent in-field tumor control in patients who have received prior radiation therapy. Toxicity was significant but manageable. The high rate of intrathoracic failure indicates the need for further study to identify patients who would derive the most benefit from SBRT for this purpose.

Kelly, Patrick [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Balter, Peter A. [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Rebueno, Neal; Sharp, Hadley J.; Liao Zhongxing; Komaki, Ritsuko [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Chang, Joe Y., E-mail: jychang@mdanderson.or [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

2010-12-01T23:59:59.000Z

59

Prospective Study of UV Exposure and Cancer Incidence Among Swedish Women  

Science Journals Connector (OSTI)

...detailed individual data on solar and artificial UV exposure in...843 subjects with a total energy intake outside the 1st and 99th...cancer incidence for either solar UV exposure (as indicated by...our study as a crude proxy of solar UV exposure. Sunburns are a...

Ling Yang; Marit B. Veierød; Marie Löf; Sven Sandin; Hans-Olov Adami; and Elisabete Weiderpass

2011-07-01T23:59:59.000Z

60

Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors  

Science Journals Connector (OSTI)

...smoke, aerosolized cooking oils, and SHS. Studies evaluating...Kleinerman RA, et al. Cooking oil fumes and risk of lung cancer...Hirayama T . Non-smoking wives of heavy smokers have a higher risk of...a case-control study in Missouri (United States). Cancer Causes...

Jonathan M. Samet; Erika Avila-Tang; Paolo Boffetta; Lindsay M. Hannan; Susan Olivo-Marston; Michael J. Thun; and Charles M. Rudin

2009-09-15T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Abstract 1079: COX-2 blockade immunologically suppresses brain metastasis of lung cancer  

Science Journals Connector (OSTI)

...COX-2 blockade immunologically suppresses brain metastasis of lung cancer Mitsugu Fujita...hypothesized that COX-2 blockade would suppress brain metastasis of cancers by inhibiting MDSC...microenvironment (TME). In both mouse and human brain metastasis cases, the expression levels...

Mitsugu Fujita; Susumu Nakata; Takeshi Okuda; Amami Kato; Osamu Yoshie

2014-10-01T23:59:59.000Z

62

DEPARTMENT OF DEFENSE LUNG CANCER RESEARCH PROGRAM FISCAL YEAR 2013 STRATEGIC PLAN  

E-Print Network [OSTI]

cancer. Screening may include, but is not limited to, computed tomography scans, X-rays, other imaging. Areas of Emphasis: The FY13 LCRP encourages research projects that specifically address the critical groundbreaking concepts in lung cancer Emphasis on innovation Preliminary data discouraged Funding: Maximum

von der Heydt, Rüdiger

63

DNA Synthesis and Repair Genes RRM1 and ERCC1 in Lung Cancer  

Science Journals Connector (OSTI)

Lung cancer accounts for more than one fourth of all cancer-related deaths in the United States, despite improvements in diagnosis and management. Only recently have molecular markers become integrated into decisions about the treatment of lung cancer, largely through the discovery of mutations in... This study of early-stage non–small-cell lung cancer showed that high levels of RRM1 in the tumor were associated with prolonged disease-free survival, as compared with low levels of RRM1. High levels of another protein in the tumor, ERCC1, were also associated with a good prognosis. The major benefit of surgery was confined to the 30% of patients in whom high levels of both RRM1 and ERCC1 were present in the tumor.

Zheng Z.; Chen T.; Li X.

2007-02-22T23:59:59.000Z

64

Forkhead Box F1 Regulates Tumor-Promoting Properties of Cancer-Associated Fibroblasts in Lung Cancer  

Science Journals Connector (OSTI)

...Washington, DC Abstract 343: Transgenic C57/BL6 x Balb/c F1 mice expressing mitochondrial targeted catalase have less...validate human lung carcinogenesis. Male C57/BL6 x Balb/c F1 (CB6 F1) mice have a high incidence of pulmonary adenocarcinoma...

Roy-Akira Saito; Patrick Micke; Janna Paulsson; Martin Augsten; Cristina Peña; Per Jönsson; Johan Botling; Karolina Edlund; Leif Johansson; Peter Carlsson; Karin Jirström; Kohei Miyazono; Arne Östman

2010-04-01T23:59:59.000Z

65

Acute Esophagus Toxicity in Lung Cancer Patients After Intensity Modulated Radiation Therapy and Concurrent Chemotherapy  

SciTech Connect (OSTI)

Purpose: The purpose of this study was to investigate the dose-effect relation between acute esophageal toxicity (AET) and the dose-volume parameters of the esophagus after intensity modulated radiation therapy (IMRT) and concurrent chemotherapy for patients with non-small cell lung cancer (NSCLC). Patients and Methods: One hundred thirty-nine patients with inoperable NSCLC treated with IMRT and concurrent chemotherapy were prospectively analyzed. The fractionation scheme was 66 Gy in 24 fractions. All patients received concurrently a daily dose of cisplatin (6 mg/m Superscript-Two ). Maximum AET was scored according to Common Toxicity Criteria 3.0. Dose-volume parameters V5 to V70, D{sub mean} and D{sub max} of the esophagus were calculated. A logistic regression analysis was performed to analyze the dose-effect relation between these parameters and grade {>=}2 and grade {>=}3 AET. The outcome was compared with the clinically used esophagus V35 prediction model for grade {>=}2 after radical 3-dimensional conformal radiation therapy (3DCRT) treatment. Results: In our patient group, 9% did not experience AET, and 31% experienced grade 1 AET, 38% grade 2 AET, and 22% grade 3 AET. The incidence of grade 2 and grade 3 AET was not different from that in patients treated with CCRT using 3DCRT. The V50 turned out to be the most significant dosimetric predictor for grade {>=}3 AET (P=.012). The derived V50 model was shown to predict grade {>=}2 AET significantly better than the clinical V35 model (P<.001). Conclusions: For NSCLC patients treated with IMRT and concurrent chemotherapy, the V50 was identified as most accurate predictor of grade {>=}3 AET. There was no difference in the incidence of grade {>=}2 AET between 3DCRT and IMRT in patients treated with concurrent chemoradiation therapy.

Kwint, Margriet [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Uyterlinde, Wilma [Department of Thoracic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Thoracic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Nijkamp, Jasper; Chen, Chun; Bois, Josien de; Sonke, Jan-Jakob [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Heuvel, Michel van den [Department of Thoracic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Thoracic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Knegjens, Joost; Herk, Marcel van [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Belderbos, Jose, E-mail: j.belderbos@nki.nl [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)

2012-10-01T23:59:59.000Z

66

Profiles of Prostaglandin Biosynthesis in Normal Lung and Tumor Tissue from Lung Cancer Patients  

Science Journals Connector (OSTI)

...Lung Biopsy Fragments Capillary gas chromatography-mass spectrometry...Fischer, S. M. Arachidonatc cascade and skin tumor promotion. In...H. T. Inhibition of murine natural killer cell activity by prostaglandins...normal human lung by capillary gas chromatography-negative ion...

Theodore L. McLemore; Walter C. Hubbard; Charles L. Litterst; Mark C. Liu; Stephan Miller; Noreen A. McMahon; Joseph C. Eggleston; and Michael R. Boyd

1988-06-01T23:59:59.000Z

67

16. DofI, R. 1978. Atmospheric pollution and lung cancer. Environ Health Perspec 22: 23-31.  

E-Print Network [OSTI]

16. DofI, R. 1978. Atmospheric pollution and lung cancer. Environ Health Perspec 22: 23-31. 17, 1976. 18. McCormick, R. A., and Holzworth, G. C. 1976. Air pollution ciimatology. In, Air Pollution, A, R. 1978. Late effects of air poliu- tion with special reference to lung cancer. Environ Health

Ahmad, Sajjad

68

Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer  

Science Journals Connector (OSTI)

...Assessments. Patients underwent baseline tumor imaging, with computed tomography or magnetic resonance imaging of the chest, abdomen, and pelvis. Brain and bone scans were obtained at baseline if disease at these sites was suspected. Tumor assessments were performed by the investigators every 8 weeks... About 1% of non–small-cell lung cancers have ROS1 rearrangements. This oncogene is inhibited by crizotinib. In a cohort of 50 patients with ROS1-rearranged lung cancer, crizotinib induced responses in 72%; the median duration of response was nearly a year and a half.

Shaw A.T.; Ou S.-H.I.; Bang Y.-J.

2014-11-20T23:59:59.000Z

69

Prostate Cancer Screening : The effect on prostate cancer mortality and incidence.  

E-Print Network [OSTI]

??abstractAt first glance, deciding whether to get the PSA screening test for prostate cancer seems to be pretty straightforward and attractive. It’s a simple blood… (more)

P.J. van Leeuwen (Pim)

2012-01-01T23:59:59.000Z

70

Responding to symptoms suggestive of lung cancer: a qualitative interview study  

E-Print Network [OSTI]

the GP two or more times before referral, during this period they reinterpreted initial symptoms and appraised new symptoms. The meaning given to symptoms changed over time and many became increasingly concerned they may have lung cancer. The GP played a...

Birt, Linda; Hall, Nicky; Emery, Jon; Banks, Jon; Mills, Katie; Johnson, Margaret; Hamilton, Willie; Walter, Fiona M.

2014-01-01T23:59:59.000Z

71

Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors  

Science Journals Connector (OSTI)

...from coal smoke generated by unventilated coal-fueled fire pits and stoves (37, 38), volatilization of oils from cooking...Mortal Wkly Rep 2005;54:625-8. 3 Thun MJ , Henley SJ, Burns D, Jemal A, Shanks TG Calle EE. Lung cancer death rates in...

Jonathan M. Samet; Erika Avila-Tang; Paolo Boffetta; Lindsay M. Hannan; Susan Olivo-Marston; Michael J. Thun; and Charles M. Rudin

2009-09-15T23:59:59.000Z

72

Epidermal Growth Factor Receptor Mutation Testing in Lung Cancer: Searching for the Ideal Method  

Science Journals Connector (OSTI)

...Yes PCR-RFLP and length analysis (15) 5 Known only Yes MALDI-TOF...non-small-cell lung cancer: analysis of a large series of cases...Nagai Y, Miyazawa H, et al. Reliability of the peptide nucleic acid-locked...massively parallel picoliter reactor sequencing. Nat Med 2006...

William Pao and Marc Ladanyi

2007-09-01T23:59:59.000Z

73

Optimal Surface Marker Locations for Tumor Motion Estimation in Lung Cancer Radiotherapy  

E-Print Network [OSTI]

, such as Intensity Modulated Radiation Therapy (IMRT), are capable of delivering highly conformal radiation dose., 2007), and the extra imaging radiation dose (Jiang, 2006b). In contrast, external surrogate based tumorOptimal Surface Marker Locations for Tumor Motion Estimation in Lung Cancer Radiotherapy Bin Dong

Soatto, Stefano

74

ENVIRONMENTAL RESEARCH 37, 364-372 (1985) Mineral Particles, Mineral Fibers, and Lung Cancer'  

E-Print Network [OSTI]

an association between lung cancer rates and concentrations of particulate air pollutants (Doll, 1978; Hitosugi, 1968; Vena, 1982), and it has been suggested that air pollution is the factor responsible exposure, and in a series of 14 control men matched for age, smoking history. and general occupational

Ahmad, Sajjad

75

Detection of aldehydes in lung cancer cell culture by gas chromatography/mass spectrometry and solid-phase microextraction with on-fiber derivatization  

E-Print Network [OSTI]

of lung cancer. 2-4 A high level of aldehydes was found both in breath and blood of lung cancer patients. Acrolein was detected in blood from patients with breast cancer. 5 The formaldehyde level from women with breast cancer was higher than...

Shan, Guangqing

2007-09-17T23:59:59.000Z

76

Tissue Heterogeneity in IMRT Dose Calculation for Lung Cancer  

SciTech Connect (OSTI)

The aim of this study was to evaluate the differences in accuracy of dose calculation between 3 commonly used algorithms, the Pencil Beam algorithm (PB), the Anisotropic Analytical Algorithm (AAA), and the Collapsed Cone Convolution Superposition (CCCS) for intensity-modulated radiation therapy (IMRT). The 2D dose distributions obtained with the 3 algorithms were compared on each CT slice pixel by pixel, using the MATLAB code (The MathWorks, Natick, MA) and the agreement was assessed with the {gamma} function. The effect of the differences on dose-volume histograms (DVHs), tumor control, and normal tissue complication probability (TCP and NTCP) were also evaluated, and its significance was quantified by using a nonparametric test. In general PB generates regions of over-dosage both in the lung and in the tumor area. These differences are not always in DVH of the lung, although the Wilcoxon test indicated significant differences in 2 of 4 patients. Disagreement in the lung region was also found when the {Gamma} analysis was performed. The effect on TCP is less important than for NTCP because of the slope of the curve at the level of the dose of interest. The effect of dose calculation inaccuracy is patient-dependent and strongly related to beam geometry and to the localization of the tumor. When multiple intensity-modulated beams are used, the effect of the presence of the heterogeneity on dose distribution may not always be easily predictable.

Pasciuti, Katia, E-mail: ka.pasciuti@libero.i [Laboratory of Medical Physics, Istituto Regina Elena, Roma (Italy); Iaccarino, Giuseppe; Strigari, Lidia [Laboratory of Medical Physics, Istituto Regina Elena, Roma (Italy); Malatesta, Tiziana [Medical Physics Department, S. Giovanni Calibita, Fatebenefratelli Hospital, Roma (Italy); Benassi, Marcello; Di Nallo, Anna Maria [Laboratory of Medical Physics, Istituto Regina Elena, Roma (Italy); Mirri, Alessandra; Pinzi, Valentina [Division of Radiotherapy, Istituto Regina Elena, Roma (Italy); Landoni, Valeria [Laboratory of Medical Physics, Istituto Regina Elena, Roma (Italy)

2011-07-01T23:59:59.000Z

77

Air Pollution from Traffic and Risk for Lung Cancer in Three Danish Cohorts  

Science Journals Connector (OSTI)

...the present study focused on vehicle traffic emissions, which is...time trends, supported by ecological correlations between the incidence...rates of adenocarcinomas and vehicle densities at county area level...and their relation to motor vehicle density. Cancer Epidemiol...

Ole Raaschou-Nielsen; Helle Bak; Mette Sørensen; Steen Solvang Jensen; Matthias Ketzel; Martin Hvidberg; Peter Schnohr; Anne Tjønneland; Kim Overvad; and Steffen Loft

2010-05-01T23:59:59.000Z

78

HMGA2 Participates in Transformation in Human Lung Cancer  

Science Journals Connector (OSTI)

...expression of abnormal HMGA2 fusion proteins. Interestingly, the...Overexpression of HMGA2-LPP fusion transcripts promotes expression...Kleeberger W, von Wasielewski HF, Kreipe H. Detection of gene...archival breast cancer specimens by laser-assisted microdissection and...

Francescopaolo Di Cello; Joelle Hillion; Alexandra Hristov; Lisa J. Wood; Mita Mukherjee; Andrew Schuldenfrei; Jeanne Kowalski; Raka Bhattacharya; Raheela Ashfaq; and Linda M.S. Resar

2008-05-01T23:59:59.000Z

79

Stereotactic Ablative Body Radiation Therapy for Octogenarians With Non-Small Cell Lung Cancer  

SciTech Connect (OSTI)

Purpose: To retrospectively investigate treatment outcomes of stereotactic ablative body radiation therapy (SABR) for octogenarians with non-small cell lung cancer (NSCLC). Methods and Materials: Between 2005 and 2012, 109 patients aged ?80 years with T1-2N0M0 NSCLC were treated with SABR: 47 patients had histology-unproven lung cancer; 62 patients had pathologically proven NSCLC. The prescribed doses were either 50 Gy/5 fractions for peripheral tumors or 40 Gy/5 fractions for centrally located tumors. The treatment outcomes, toxicities, and the correlating factors for overall survival (OS) were evaluated. Results: The median follow-up duration after SABR was 24.2 (range, 3.0-64.6) months. Only limited toxicities were observed, except for 1 grade 5 radiation pneumonitis. The 3-year local, regional, and distant metastasis-free survival rates were 82.3%, 90.1%, and 76.8%, respectively. The OS and lung cancer-specific survival rates were 53.7% and 70.8%, respectively. Multivariate analysis revealed that medically inoperable, low body mass index, high T stage, and high C-reactive protein were the predictors for short OS. The OS for the operable octogenarians was significantly better than that for inoperable (P<.01). Conclusions: Stereotactic ablative body radiation therapy for octogenarians was feasible, with excellent OS. Multivariate analysis revealed that operability was one of the predictors for OS. For medically operable octogenarians with early-stage NSCLC, SABR should be prospectively compared with resection.

Takeda, Atsuya; Sanuki, Naoko; Eriguchi, Takahisa [Radiation Oncology Center, Ofuna Chuo Hospital, Kanagawa (Japan)] [Radiation Oncology Center, Ofuna Chuo Hospital, Kanagawa (Japan); Kaneko, Takeshi [Respiratory Disease Center, Yokohama City University Medical Center, Kanagawa (Japan) [Respiratory Disease Center, Yokohama City University Medical Center, Kanagawa (Japan); Department of Respirology, Ofuna Chuo Hospital, Kanagawa (Japan); Morita, Satoshi [Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama City University, Kanagawa (Japan)] [Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama City University, Kanagawa (Japan); Handa, Hiroshi [Respiratory Disease Center, Yokohama City University Medical Center, Kanagawa (Japan) [Respiratory Disease Center, Yokohama City University Medical Center, Kanagawa (Japan); Division of Respiratory and Infectious Diseases, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa (Japan); Aoki, Yousuke; Oku, Yohei [Radiation Oncology Center, Ofuna Chuo Hospital, Kanagawa (Japan)] [Radiation Oncology Center, Ofuna Chuo Hospital, Kanagawa (Japan); Kunieda, Etsuo, E-mail: kunieda-mi@umin.ac.jp [Department of Radiation Oncology, Tokai University, Kanagawa (Japan)] [Department of Radiation Oncology, Tokai University, Kanagawa (Japan)

2013-06-01T23:59:59.000Z

80

Modeling and predicting the occurrence of brain metastasis from lung cancer by Bayesian network: A case study of Taiwan  

Science Journals Connector (OSTI)

The Bayesian network (BN) is a promising method for modeling cancer metastasis under uncertainty. BN is graphically represented using bioinformatics variables and can be used to support an informative medical decision/observation by using probabilistic ... Keywords: Bayesian network, Brain metastasis, Lung cancer

Kung-Jeng Wang, Bunjira Makond, Kung-Min Wang

2014-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Tobacco Smoking, Motor Exhaust Fumes, and General Air Pollution in Relation to Lung Cancer Incidence  

Science Journals Connector (OSTI)

...patients to represent the general populations from which...urban motor traffic or to general urban air pollution...Particulate Phase of Gaso line Engine Exhaust and the Carcinogenicity...Particulate Phase of Diesel Engine Exhausts and the Carcinogenicity...

Clarence A. Mills and Marjorie Mills Porter

1957-11-01T23:59:59.000Z

82

CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells  

SciTech Connect (OSTI)

Highlights: •CDK-associated Cullin 1 (CAC1) expression increases in human lung carcinoma. •CAC1 promotes the proliferation of lung cancer A549 cells. •CAC1 promotes human lung cancer A549 cell proliferation with activation of ERK1/2. -- Abstract: Lung cancer is one of the most common causes of cancer-related death in the world, but the mechanisms remain unknown. In this study, we investigated the expression of CDK-associated Cullin 1 (CAC1) in lung cancer, the effect of CAC1 on the proliferation of human lung cancer A549 cells, and the activation of signaling pathways of mitogen-activated protein kinases (MAPKs). Results showed that CAC1 expression was higher levels in human lung carcinoma than normal lung tissue, and CAC1 siRNA reduced the proliferation of lung cancer A549 cells by decreasing cell activity and cell division in vitro. The proportion of cells treated with CAC1 siRNA increased in the G1 phase and decreased in the S and G2/M phase, indicative of G1 cell cycle arrest. Furthermore, the proportions of early/late apoptosis in lung cancer A549 cells were enhanced with CAC1 siRNA treatment. It was also found that activation of extracellular signal-regulated protein kinase (ERK) and p38 signaling pathways were involved in the proliferation of A549 cells. After CAC1 siRNA treatment, p-ERK1/2 levels decreased, and meanwhile p-p38 level increased, A549 cell proliferation increased when ERK1/2 signaling is activated by PMA. Our findings demonstrated that CAC1 promoted the proliferation of human lung cancer A549 cells with activation of ERK1/2 signaling pathways, suggesting a potential cure target for treatment of human lung cancer.

Chen, Tian Jun [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China)] [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China); Gao, Fei [Hua-shan Central Hospital of Xi’an, Xi’an 710043 (China)] [Hua-shan Central Hospital of Xi’an, Xi’an 710043 (China); Yang, Tian; Thakur, Asmitanand; Ren, Hui; Li, Yang; Zhang, Shuo; Wang, Ting [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China)] [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China); Chen, Ming Wei, E-mail: xjtucmw@163.com [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China)

2013-07-19T23:59:59.000Z

83

Silencing of poly(ADP-ribose) glycohydrolase sensitizes lung cancer cells to radiation through the abrogation of DNA damage checkpoint  

SciTech Connect (OSTI)

Highlights: •Radiosensitization by PARG silencing was observed in multiple lung cancer cells. •PAR accumulation was enhanced by PARG silencing after DNA damage. •Radiation-induced G2/M arrest and checkpoint activation were impaired by PARG siRNA. -- Abstract: Poly(ADP-ribose) glycohydrolase (PARG) is a major enzyme that plays a role in the degradation of poly(ADP-ribose) (PAR). PARG deficiency reportedly sensitizes cells to the effects of radiation. In lung cancer, however, it has not been fully elucidated. Here, we investigated whether PARG siRNA contributes to an increased radiosensitivity using 8 lung cancer cell lines. Among them, the silencing of PARG induced a radiosensitizing effect in 5 cell lines. Radiation-induced G2/M arrest was largely suppressed by PARG siRNA in PC-14 and A427 cells, which exhibited significantly enhanced radiosensitivity in response to PARG knockdown. On the other hand, a similar effect was not observed in H520 cells, which did not exhibit a radiosensitizing effect. Consistent with a cell cycle analysis, radiation-induced checkpoint signals were not well activated in the PC-14 and A427 cells when treated with PARG siRNA. These results suggest that the increased sensitivity to radiation induced by PARG knockdown occurs through the abrogation of radiation-induced G2/M arrest and checkpoint activation in lung cancer cells. Our findings indicate that PARG could be a potential target for lung cancer treatments when used in combination with radiotherapy.

Nakadate, Yusuke [Shien-Lab, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan) [Shien-Lab, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Department of Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan); Kodera, Yasuo; Kitamura, Yuka [Shien-Lab, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [Shien-Lab, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Tachibana, Taro [Department of Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan)] [Department of Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan); Tamura, Tomohide [Division of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [Division of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Koizumi, Fumiaki, E-mail: fkoizumi@ncc.go.jp [Division of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [Division of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)

2013-11-29T23:59:59.000Z

84

Serum Amyloid A as a Predictive Marker for Radiation Pneumonitis in Lung Cancer Patients  

SciTech Connect (OSTI)

Purpose: To investigate serum markers associated with radiation pneumonitis (RP) grade ?3 in patients with lung cancer who were treated with radiation therapy. Methods and Materials: Pretreatment serum samples from patients with stage Ib-IV lung cancer who developed RP within 1 year after radiation therapy were analyzed to identify a proteome marker able to stratify patients prone to develop severe RP by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). Dosimetric parameters and 3 biological factors were compared. Results: Serum samples from 16 patients (28%) with severe RP (grade 3-4) and 42 patients (72%) with no or mild RP (grade 0-2) were collected for analysis. All patients received a median of 54 Gy (range, 42-70 Gy) of three-dimensional conformal radiation therapy with a mean lung dose (MLD) of 1502 cGy (range, 700-2794 cGy). An m/z peak of 11,480 Da was identified by SELDI-TOF-MS, and serum amyloid A (SAA) was the primary splitter serum marker. The receiver operating characteristic area under the curve of SAA (0.94; 95% confidence interval [CI], 0.87-1.00) was higher than those of C-reactive protein (0.83; 95% CI, 0.72-0.94), interleukin-6 (0.79; 95% CI, 0.65-0.94), and MLD (0.57; 95% CI, 0.37-0.77). The best sensitivity and specificity of combined SAA and MLD for predicting RP were 88.9% and 96.0%, respectively. Conclusions: Baseline SAA could be used as an auxiliary marker for predicting severe RP. Extreme care should be taken to limit the lung irradiation dose in patients with high SAA.

Wang, Yu-Shan [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China) [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Department of Animal Science, National Ilan University, Ilan, Taiwan (China); Chang, Heng-Jui [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Chang, Yue-Cune [Department of Mathematics, Tamkang University, Taipei, Taiwan (China)] [Department of Mathematics, Tamkang University, Taipei, Taiwan (China); Huang, Su-Chen; Ko, Hui-Ling; Chang, Chih-Chia [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Yeh, Yu-Wung; Jiang, Jiunn-Song [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Lee, Cheng-Yen; Chi, Mau-Shin [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Chi, Kwan-Hwa, E-mail: M006565@ms.skh.org.tw [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China) [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Institute of Radiation Science and School of Medicine, National Yang-Ming University, Taipei, Taiwan (China)

2013-03-01T23:59:59.000Z

85

Thyroid Cancer Incidence among Active Duty U.S. Military Personnel, 1990–2004  

Science Journals Connector (OSTI)

...immunizations and depleted uranium, may also influence cancer risk among...to prostate cancer, although...inconsistent, depleted uranium (the material...for prostate cancer (36). Because...exposed to depleted uranium, these factors...

Lindsey R. Enewold; Jing Zhou; Susan S. Devesa; Amy Berrington de Gonzalez; William F. Anderson; Shelia H. Zahm; Alexander Stojadinovic; George E. Peoples; Aizenhawar J. Marrogi; John F. Potter; Katherine A. McGlynn; and Kangmin Zhu

2011-11-01T23:59:59.000Z

86

Cancer Incidence in the U.S. Military Population: Comparison with Rates from the SEER Program  

Science Journals Connector (OSTI)

...Carcinogens Proc Amer Assoc Cancer Res, Volume 47, 2006...like cadmium can induce cancer in unexposed offspring...France [Proc Amer Assoc Cancer Res, Volume 47, 2006...of heavy metals like depleted uranium (DU) and tungsten alloy...

Kangmin Zhu; Susan S. Devesa; Hongyu Wu; Shelia Hoar Zahm; Ismail Jatoi; William F. Anderson; George E. Peoples; Larry G. Maxwell; Elder Granger; John F. Potter; and Katherine A. McGlynn

2009-06-01T23:59:59.000Z

87

Low Dose Radiation Research Program: Biologically Based Analysis of Lung  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biologically Based Analysis of Lung Cancer Incidence in a Large Biologically Based Analysis of Lung Cancer Incidence in a Large Canadian Occupational Cohort with Low-LET Low-dose Radiation Exposure, and Comparison with Japanese Atomic Bomb Survivors. Authors: W.D. Hazelton, D. Krewski, S.H. Moolgavkar Lung cancer incidence is analyzed in a large Canadian National Dose Registry (CNDR) cohort with individual annual dosimetry for low-dose occupational exposure to gamma and tritium radiation using several types of multistage models. The primary analysis utilizes the two-stage clonal expansion model (TSCE), with sensitivity analyses using extensions of this model incorporating additional stages. Characteristic and distinct temporal patterns of risk are found for dose-response affecting early, middle, or late stages of carcinogenesis, e.g., initiation with one or more stages,

88

Novel Mutations in a Patient with ALK-Rearranged Lung Cancer  

Science Journals Connector (OSTI)

To the Editor: A 49-year-old nonsmoking woman presented with pleuritic pain on the right side of her chest. Computed tomography (CT) of the chest revealed a spiculated, noncalcified pulmonary nodule in the right middle lobe 1.2 cm in diameter and multiple noncalcified nodules (2.0 to 3.0 mm in... A variety of mechanisms of crizotinib resistance have been defined in patients with ALK-rearranged lung cancer who no longer have a response to the drug. A case is presented in which the tumor lost the rearrangement and mutations developed in several other genes.

2014-10-23T23:59:59.000Z

89

First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer  

Science Journals Connector (OSTI)

...which included all patients who underwent randomization. The Kaplan–Meier method was used to estimate time-to-event end points. Two-sided log-rank tests stratified according to baseline stratification factors were used for between-group comparisons of progression-free survival and overall survival; stratified... The ALK inhibitor crizotinib as first-line therapy was associated with a significantly better response rate, longer progression-free survival, and greater improvement in quality of life measures than standard chemotherapy in patients with ALK-positive lung cancer.

Solomon B.J.; Mok T.; Kim D.-W.

2014-12-04T23:59:59.000Z

90

Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells  

SciTech Connect (OSTI)

Histone deacetylase 6 (HDAC6) is a multifunctional, cytosolic protein deacetylase that primarily acts on {alpha}-tubulin. Here we report that stable knockdown of HDAC6 expression causes a decrease in the steady-state level of receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor {alpha}, in A549 lung cancer cells. The decreased levels of in EGFR in HDAC6-knockdown cells, which correlated with increased acetylation of microtubules, were due to increased turnover of EGFR protein. Despite the decrease in EGFR levels, A549 cells lacking functional HDAC6 appeared to grow normally, probably due to increased expression of extracellular signal-regulated kinases 1 and 2. Indeed, HDAC6-knockdown cells were more sensitive than control cells to the MEK inhibitor U0126. These results suggest that HDAC6 inhibitors combined with inhibitors of growth factor signaling may be useful as cancer therapy.

Kamemura, Kazuo [Chemical Genetics Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351-0198 (Japan); Japan Science and Technology Corporation, CREST Research Project, Kawaguchi, Saitama 332-0012 (Japan); Ito, Akihiro [Chemical Genetics Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351-0198 (Japan); Chemical Genomics Research Group, RIKEN Advanced Science Institute, Wako, Saitama 351-0198 (Japan)], E-mail: akihiro-i@riken.jp; Shimazu, Tadahiro [Chemical Genetics Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351-0198 (Japan); Matsuyama, Akihisa [Chemical Genetics Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351-0198 (Japan); Chemical Genomics Research Group, RIKEN Advanced Science Institute, Wako, Saitama 351-0198 (Japan); Japan Science and Technology Corporation, CREST Research Project, Kawaguchi, Saitama 332-0012 (Japan); Maeda, Satoko [Chemical Genetics Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351-0198 (Japan); Yao, Tso-Pang [Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710 (United States); Horinouchi, Sueharu [Department of Biotechnology, University of Tokyo, Tokyo 113-8657 (Japan); Khochbin, Saadi [INSERM U309, Institut Albert Bonniot, Faculte de Medecine, Domaine de la Merci, 38706 La Tronche Cedex (France); Yoshida, Minoru [Chemical Genetics Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351-0198 (Japan); Chemical Genomics Research Group, RIKEN Advanced Science Institute, Wako, Saitama 351-0198 (Japan); Japan Science and Technology Corporation, CREST Research Project, Kawaguchi, Saitama 332-0012 (Japan); Department of Biotechnology, University of Tokyo, Tokyo 113-8657 (Japan)

2008-09-12T23:59:59.000Z

91

Lung cancer in uranium miners and the implications of the U/V ratio in uranium-bearing particles  

SciTech Connect (OSTI)

Several geological formations mined for uranium ore during and after the second World War had been mined earlier for vanadium. Most miners and millers from the Utah-Colorado mining region worked with this ore or its tailings at one time or another. Preliminary investigation to determine the size and location of uranium-bearing particles retained in the lungs of a former uranium miner and miller from this region, who died of lung cancer (mesothelioma), showed a high nonuniform distribution of vanadium. This observation leads to the hypothesis that the vanadium content in that lung could be associated with inhaled particles. Further examination of spectra of characteristic x-rays obtained by scanning microPIXE (particle induced x-ray emission) of an autopsy sample of this lung indicated that vanadium was indeed present in localized sites within the 20 ..mu..m spatial resolution of the proton beam. This work points out that the vanadium found in the lungs of this former miner and miller is nonuniformly distributed, and can be used for site localization and size determination of inhaled particles retained in the lungs. The meaning of U/V ratios in dust particles and in lungs is discussed. Further studies are in progress to: (1) locate uranium-bearing particles in lung tissues of former uranium miners and millers; and (2) evaluate the local alpha doses received from these particles. 11 refs., 3 figs., 1 tab.

Paschoa, A.S.; Wrenn, M.E.; Singh, N.P.; Bruenger, F.W.; Miller, S.C.; Cholewa, M.; Jones, K.W.

1985-01-01T23:59:59.000Z

92

On the interplay effects with proton scanning beams in stage III lung cancer  

SciTech Connect (OSTI)

Purpose: To assess the dosimetric impact of interplay between spot-scanning proton beam and respiratory motion in intensity-modulated proton therapy (IMPT) for stage III lung cancer. Methods: Eleven patients were sampled from 112 patients with stage III nonsmall cell lung cancer to well represent the distribution of 112 patients in terms of target size and motion. Clinical target volumes (CTVs) and planning target volumes (PTVs) were defined according to the authors' clinical protocol. Uniform and realistic breathing patterns were considered along with regular- and hypofractionation scenarios. The dose contributed by a spot was fully calculated on the computed tomography (CT) images corresponding to the respiratory phase that the spot is delivered, and then accumulated to the reference phase of the 4DCT to generate the dynamic dose that provides an estimation of what might be delivered under the influence of interplay effect. The dynamic dose distributions at different numbers of fractions were compared with the corresponding 4D composite dose which is the equally weighted average of the doses, respectively, computed on respiratory phases of a 4DCT image set. Results: Under regular fractionation, the average and maximum differences in CTV coverage between the 4D composite and dynamic doses after delivery of all 35 fractions were no more than 0.2% and 0.9%, respectively. The maximum differences between the two dose distributions for the maximum dose to the spinal cord, heart V40, esophagus V55, and lung V20 were 1.2 Gy, 0.1%, 0.8%, and 0.4%, respectively. Although relatively large differences in single fraction, correlated with small CTVs relative to motions, were observed, the authors' biological response calculations suggested that this interfractional dose variation may have limited biological impact. Assuming a hypofractionation scenario, the differences between the 4D composite and dynamic doses were well confined even for single fraction. Conclusions: Despite the presence of interplay effect, the delivered dose may be reliably estimated using the 4D composite dose. In general the interplay effect may not be a primary concern with IMPT for lung cancers for the authors' institution. The described interplay analysis tool may be used to provide additional confidence in treatment delivery.

Li, Yupeng [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and Applied Research, Varian Medical Systems, Palo Alto, California 94304 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and Applied Research, Varian Medical Systems, Palo Alto, California 94304 (United States); Kardar, Laleh; Liao, Li; Lim, Gino [Department of Industrial Engineering, The University of Houston, Houston, Texas 77204 (United States)] [Department of Industrial Engineering, The University of Houston, Houston, Texas 77204 (United States); Li, Xiaoqiang; Li, Heng; Zhu, Ronald X.; Sahoo, Narayan; Gillin, Michael; Zhang, Xiaodong, E-mail: xizhang@mdanderson.org [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Cao, Wenhua [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and Department of Industrial Engineering, The University of Houston, Houston, Texas 77204 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and Department of Industrial Engineering, The University of Houston, Houston, Texas 77204 (United States); Chang, Joe Y.; Liao, Zhongxing; Komaki, Ritsuko; Cox, James D. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)

2014-02-15T23:59:59.000Z

93

Lung cancer in uranium miners: A tissue resource and pilot study. Final performance report  

SciTech Connect (OSTI)

This project incorporates two related research projects directed toward understanding respiratory carcinogenesis in radon-exposed former uranium miners. The first project involved a continuation of the tissue resource of lung cancer cases from former underground uranium miners and comparison cases from non-miners. The second project was a pilot study for a proposed longitudinal study of respiratory carcinogenesis in former uranium miners. The objectives including facilitating the investigation of molecular changes in radon exposed lung cancer cases, developing methods for prospectively studying clinical, cytologic, cytogenetic, and molecular changes in the multi-event process of respiratory carcinogenesis, and assessing the feasibility of recruiting former uranium miners into a longitudinal study that collected multiple biological specimens. A pilot study was conducted to determine whether blood collection, induced sputum, bronchial brushing, washings, and mucosal biopsies from participants at two of the hospitals could be included efficiently. A questionnaire was developed for the extended study and all protocols for specimen collection and tissue handling were completed. Resource utilization is in progress at ITRI and the methods have been developed to study molecular and cellular changes in exfoliated cells contained in sputum as well as susceptibility factors.

Samet, J.; Gilliland, F.D.

1998-08-13T23:59:59.000Z

94

Dosimetric comparison of patient setup strategies in stereotactic body radiation therapy for lung cancer  

SciTech Connect (OSTI)

Purpose: In this work, the authors retrospectively compared the accumulated dose over the treatment course for stereotactic body radiation therapy (SBRT) of lung cancer for three patient setup strategies. Methods: Ten patients who underwent lung SBRT were selected for this study. At each fraction, patients were immobilized using a vacuum cushion and were CT scanned. Treatment plans were performed on the simulation CT. The planning target volume (PTV) was created by adding a 5-mm uniform margin to the internal target volume derived from the 4DCT. All plans were normalized such that 99% of the PTV received 60 Gy. The plan parameters were copied onto the daily CT images for dose recalculation under three setup scenarios: skin marker, bony structure, and soft tissue based alignments. The accumulated dose was calculated by summing the dose at each fraction along the trajectory of a voxel over the treatment course through deformable image registration of each CT with the planning CT. The accumulated doses were analyzed for the comparison of setup accuracy. Results: The tumor volume receiving 60 Gy was 91.7 {+-} 17.9%, 74.1 {+-} 39.1%, and 99.6 {+-} 1.3% for setup using skin marks, bony structures, and soft tissue, respectively. The isodose line covering 100% of the GTV was 55.5 {+-} 7.1, 42.1 {+-} 16.0, and 64.3 {+-} 7.1 Gy, respectively. The corresponding average biologically effective dose of the tumor was 237.3 {+-} 29.4, 207.4 {+-} 61.2, and 258.3 {+-} 17.7 Gy, respectively. The differences in lung biologically effective dose, mean dose, and V20 between the setup scenarios were insignificant. Conclusions: The authors' results suggest that skin marks and bony structure are insufficient for aligning patients in lung SBRT. Soft tissue based alignment is needed to match the prescribed dose delivered to the tumors.

Wu Jianzhou; He, Tongming T. [Radiation Oncology, Swedish Cancer Institute, Seattle, Washington 98104 (United States); Betzing, Christopher; Fuss, Martin [Department of Radiation Medicine, Oregon Health and Science University, Portland, Oregon 97239 (United States); D'Souza, Warren D. [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland 21044 (United States)

2013-05-15T23:59:59.000Z

95

Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D and Risk of Incident Ovarian Cancer  

Science Journals Connector (OSTI)

...the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer 2002...1867-75. 20 Grant WB. Ecologic studies of solar UV-B radiation and cancer mortality rates...cancer risk: a case-control study in Mexico. Oncology 2002;63:151-7. 24 Genkinger...

Shelley S. Tworoger; I-Min Lee; Julie E. Buring; Bernard Rosner; Bruce W. Hollis; and Susan E. Hankinson

2007-04-01T23:59:59.000Z

96

GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: A meta-analysis  

Science Journals Connector (OSTI)

...worlds population is exposed to smoke from coal, wood, or biomass used in heating and cooking. These environmental exposures...of lung cancer among individuals exposed to coal, wood and biomass smoke and cooking oil fumes. We performed a meta-analysis...

H Hosgood; Sonja Berndt; Qing Lan

2007-05-01T23:59:59.000Z

97

A Novel Function of YWHAZ/?-Catenin Axis in Promoting Epithelial–Mesenchymal Transition and Lung Cancer Metastasis  

Science Journals Connector (OSTI)

...Erickson P, Bemis L, Li E, et alAltered HOX and WNT7A expression in human lung cancer.Proc Natl Acad Sci U S A 2000;97:12776-81. 40. Kase S , Sugio K, Yamazaki K, Okamoto T, Yano T, Sugimachi K.Expression of E-cadherin and beta-catenin...

Ching-Hsien Chen; Show-Mei Chuang; Meng-Fang Yang; Jiunn-Wang Liao; Sung-Liang Yu; Jeremy J.W. Chen

2012-10-01T23:59:59.000Z

98

A Strategy for Bounding Attributable Risk: a Lung Cancer Example Minh Ha-Duong1,2  

E-Print Network [OSTI]

. Casman2 , and M. Granger. Morgan2 1 Centre International de Recherche sur l'Environnement et le, residential radon, and asbestos fibers) and describe the uncertainty surrounding those estimates Deaths, 2000 Projected Lung Cancer Deaths, 2003(2) ** All persons 56.5 281,421,906 159,200 157,200 Male

Paris-Sud XI, Université de

99

Association of Carcinogenic Polycyclic Aromatic Hydrocarbon Emissions and Smoking with Lung Cancer Mortality Rates on a Global Scale  

Science Journals Connector (OSTI)

(2, 4) For most populations, approximately 80% of all lung cancer cases are associated with tobacco smoking and the remaining 20% have been attributed to exposure to secondhand smoke, radon (and its decay products), asbestos, some metals (including arsenic, beryllium, cadmium), organic compounds (including carcinogenic polycyclic aromatic hydrocarbons (PAHs)), radiation, and genetic susceptibility. ...

Oleksii Motorykin; Melissa M. Matzke; Katrina M. Waters; Staci L. Massey Simonich

2013-03-08T23:59:59.000Z

100

Prospective study evaluating the use of IV contrast on IMRT treatment planning for lung cancer  

SciTech Connect (OSTI)

Purpose: To investigate the impact of exclusively using intravenous (IV) contrast x-ray computed tomography (CT) scans on lung cancer intensity-modulated radiation therapy (IMRT) treatment planning. Methods: Eight patients with lung cancer (one small cell, seven nonsmall cell) scheduled to receive IMRT consented to acquisition of simulation CT scans with and without IV contrast. Clinical treatment plans optimized on the noncontrast scans were recomputed on contrast scans and dose coverage was compared, along with the ? passing rates. Results: IV contrast enhanced scans provided better target and critical structure conspicuity than the noncontrast scans. Using noncontrast scan as a reference, the median absolute/relative differences in mean, maximum, and minimum doses to the planning target volume (PTV) were ?4.5 cGy/?0.09%, 41.1 cGy/0.62%, and ?19.7 cGy/?0.50%, respectively. Regarding organs-at-risk (OARs), the median absolute/relative differences of maximum dose to heart was ?13.3 cGy/?0.32%, to esophagus was ?63.4 cGy/?0.89%, and to spinal cord was ?16.3 cGy/?0.46%. The median heart region of interest CT Hounsfield Unit (HU) number difference between noncontrast and contrast scans was 136.4 HU (range, 94.2–161.8 HU). Subjectively, the regions with absolute dose differences greater than 3% of the prescription dose were small and typically located at the patient periphery and/or at the beam edges. The median ? passing rate was 0.9981 (range, 0.9654–0.9999) using 3% absolute dose difference/3 mm distance-to-agreement criteria. Overall, all evaluated cases were found to be clinically equivalent. Conclusions: PTV and OARs dose differences between noncontrast and contrast scans appear to be minimal for lung cancer patients undergoing IMRT. Using IV contrast scans as the primary simulation dataset could increase treatment planning efficiency and accuracy by avoiding unnecessary scans, manually region overriding, and planning errors caused by nonperfect image registrations.

Li, Hua, E-mail: huli@radonc.wustl.edu; Bottani, Beth; DeWees, Todd; Michalski, Jeff M.; Mutic, Sasa; Bradley, Jeffrey D.; Robinson, Clifford G. [Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, Missouri 63110 (United States)] [Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, Missouri 63110 (United States); Low, Daniel A. [Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California 90095 (United States)] [Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California 90095 (United States)

2014-03-15T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

LUNG CANCER 6. LUNG CANCER  

E-Print Network [OSTI]

OF IRELAND New Zealand Australia Poland Belgium Czech Republic Austria Sweden Germany Japan Italy Spain NORTHERN IRELAND Canada REPUBLIC OF IRELAND Japan United Kingdom Austria Norway Australia New Zealand Indoor emissions from household combustion of coal 1,12 Low socio-economic status 13 Family history

Paxton, Anthony T.

102

Mapping and analysing cancer incidence in South Africa / Samuel Jacobus Jansen van Rensburg.  

E-Print Network [OSTI]

??The primary aim of this dissertation was to develop and validate a methodology for identifying spatial clusters (hotspots) of various paediatric cancers within South Africa… (more)

Van Rensburg, Samuel Jacobus Jansen

2014-01-01T23:59:59.000Z

103

A Virus That Can Infect Lung Cancer Cells | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Plant Viruses Could Yield New Ways to Safeguard Crops Imaging Plant Viruses Could Yield New Ways to Safeguard Crops Extreme Pressure Reveals a Volume Expansion Phenomenon A Nuclear Receptor with Implications for a Host of Diseases Unexpected Materials in Earth's Lowermost Mantle Nailing Down the Exciton in LiF Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Virus That Can Infect Lung Cancer Cells OCTOBER 21, 2008 Bookmark and Share The 3-D structure of Seneca Valley Virus-001. (Courtesy: The Scripps Research Institute) The structure of the Senecavirus is also depicted at http://viperdb.scripps.edu/, the "Virus Particle Explorer" developed at Scripps Research by Reddy and his colleagues. The online database is a

104

Impact of Four-Dimensional Computed Tomography Pulmonary Ventilation Imaging-Based Functional Avoidance for Lung Cancer Radiotherapy  

SciTech Connect (OSTI)

Purpose: To quantify the dosimetric impact of four-dimensional computed tomography (4D-CT) pulmonary ventilation imaging-based functional treatment planning that avoids high-functional lung regions. Methods and Materials: 4D-CT ventilation images were created from 15 non-small-cell lung cancer patients using deformable image registration and quantitative analysis of the resultant displacement vector field. For each patient, anatomic and functional plans were created for intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT). Consistent beam angles and dose-volume constraints were used for all cases. The plans with Radiation Therapy Oncology Group (RTOG) 0617-defined major deviations were modified until clinically acceptable. Functional planning spared the high-functional lung, and anatomic planning treated the lungs as uniformly functional. We quantified the impact of functional planning compared with anatomic planning using the two- or one-tailed t test. Results: Functional planning led to significant reductions in the high-functional lung dose, without significantly increasing other critical organ doses, but at the expense of significantly degraded the planning target volume (PTV) conformity and homogeneity. The average reduction in the high-functional lung mean dose was 1.8 Gy for IMRT (p < .001) and 2.0 Gy for VMAT (p < .001). Significantly larger changes occurred in the metrics for patients with a larger amount of high-functional lung adjacent to the PTV. Conclusion: The results of the present study have demonstrated the impact of 4D-CT ventilation imaging-based functional planning for IMRT and VMAT for the first time. Our findings indicate the potential of functional planning in lung functional avoidance for both IMRT and VMAT, particularly for patients who have high-functional lung adjacent to the PTV.

Yamamoto, Tokihiro, E-mail: Tokihiro@stanford.ed [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA (United States); Kabus, Sven; Berg, Jens von; Lorenz, Cristian [Department of Digital Imaging, Philips Research Europe, Hamburg (Germany); Keall, Paul J. [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA (United States)

2011-01-01T23:59:59.000Z

105

Local Failure in Resected N1 Lung Cancer: Implications for Adjuvant Therapy  

SciTech Connect (OSTI)

Purpose: To evaluate actuarial rates of local failure in patients with pathologic N1 non-small-cell lung cancer and to identify clinical and pathologic factors associated with an increased risk of local failure after resection. Methods and Materials: All patients who underwent surgery for non-small-cell lung cancer with pathologically confirmed N1 disease at Duke University Medical Center from 1995-2008 were identified. Patients receiving any preoperative therapy or postoperative radiotherapy or with positive surgical margins were excluded. Local failure was defined as disease recurrence within the ipsilateral hilum, mediastinum, or bronchial stump/staple line. Actuarial rates of local failure were calculated with the Kaplan-Meier method. A Cox multivariate analysis was used to identify factors independently associated with a higher risk of local recurrence. Results: Among 1,559 patients who underwent surgery during the time interval, 198 met the inclusion criteria. Of these patients, 50 (25%) received adjuvant chemotherapy. Actuarial (5-year) rates of local failure, distant failure, and overall survival were 40%, 55%, and 33%, respectively. On multivariate analysis, factors associated with an increased risk of local failure included a video-assisted thoracoscopic surgery approach (hazard ratio [HR], 2.5; p = 0.01), visceral pleural invasion (HR, 2.1; p = 0.04), and increasing number of positive N1 lymph nodes (HR, 1.3 per involved lymph node; p = 0.02). Chemotherapy was associated with a trend toward decreased risk of local failure that was not statistically significant (HR, 0.61; p = 0.2). Conclusions: Actuarial rates of local failure in pN1 disease are high. Further investigation of conformal postoperative radiotherapy may be warranted.

Higgins, Kristin A., E-mail: kristin.higgins@duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Chino, Junzo P. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Berry, Mark [Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC (United States); Ready, Neal [Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC (United States); Boyd, Jessamy [US Oncology, Dallas, TX (United States); Yoo, David S.; Kelsey, Chris R. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)

2012-06-01T23:59:59.000Z

106

Prospective Study of UV Exposure and Cancer Incidence Among Swedish Women  

Science Journals Connector (OSTI)

...protective effect of solar UV exposure on cancer...19), Italy (20), Mexico (21), and the United...inverse association between solar UV exposure and cancer...case-control study in Mexico.Oncology 2002;63...additional evidence that solar ultraviolet-B irradiance...

Ling Yang; Marit B. Veierød; Marie Löf; Sven Sandin; Hans-Olov Adami; and Elisabete Weiderpass

2011-07-01T23:59:59.000Z

107

Incidence of Colorectal Cancer in Relation to Glycemic Index and Load in a Cohort of Women  

Science Journals Connector (OSTI)

...GI/GL had low power. Our study population...glycemic diet. Our data support recently...Dietary glycemic load and colorectal cancer...al Supplementary Data, McCarl et al Files in this Data Supplement: Supplementary...glycemic index and load in a cohort of women...

Mary McCarl; Lisa Harnack; Paul J. Limburg; Kristin E. Anderson; and Aaron R. Folsom

2006-05-01T23:59:59.000Z

108

No Association Between Dietary Glycemic Index or Load and Pancreatic Cancer Incidence in Postmenopausal Women  

Science Journals Connector (OSTI)

...glycemic index|glycemic load|pancreatic cancer...GI) and glycemic load (GL) values have...Cancer Registry. Data Analysis We excluded...being tested. Our power was 80 to detect a...biologically plausible, the data from our study do...Brand-Miller JC. Glycemic load and chronic disease...

Kimberly J. Johnson; Kristin E. Anderson; Lisa Harnack; Ching-Ping Hong; and Aaron R. Folsom

2005-06-01T23:59:59.000Z

109

A Web Tool for Age–Period–Cohort Analysis of Cancer Incidence and Mortality Rates  

Science Journals Connector (OSTI)

...research-article Cancer Surveillance Research A Web Tool for Age-Period-Cohort Analysis of Cancer...that can be accessed through a user-friendly Web tool. Results: Input data for the Web tool consist of age-specific numbers of events...

Philip S. Rosenberg; David P. Check; William F. Anderson

2014-11-01T23:59:59.000Z

110

A Web Tool for Age–Period–Cohort Analysis of Cancer Incidence and Mortality Rates  

Science Journals Connector (OSTI)

...research-article Cancer Surveillance Research A Web Tool for Age-Period-Cohort Analysis of Cancer...that can be accessed through a user-friendly Web tool. Results: Input data for the Web tool consist of age-specific numbers of events...

Philip S. Rosenberg; David P. Check; William F. Anderson

111

Metabolic Syndrome, Vitamin D Status, and the Incidence of Prostate Cancer  

E-Print Network [OSTI]

ABSTRACT Background: Epidemiologic data on the role of metabolic syndrome on prostate cancer risk is inconsistent, and only one case-control trial has examined the combined relationship of metabolic syndrome and vitamin D deficiency. Objective...

Rorabaugh, Joseph Randall

2012-08-31T23:59:59.000Z

112

Abstract 4172: Identification of a low PTEN / high PI3K? expressing subset of squamous non-small-cell lung cancer (NSCLC)  

Science Journals Connector (OSTI)

...Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer Yangsik...biomarkers and new therapeutic targets. Nuclear receptors are druggable targets due to...using publicly available microarray datasets, we found that the NR signature has a...

Garry Beran; Xi M. Tang; Marie Cumberbatch; Sally Luke; Pritibha Singh; Alexander Kvist; Sabina Cosulich; Paul D. Smith; Carmen Behrens; Edward S. Kim; Chris Womack; Neil Gray; Ignacio I. Wistuba; and David P. Blowers

2012-04-15T23:59:59.000Z

113

Comparison of demographics, treatment patterns, health care utilization, and costs among elderly patients with extensive-stage small cell and metastatic non-small cell lung cancers  

Science Journals Connector (OSTI)

Limited data exist regarding real-world treatment patterns, resource utilization, and costs of extensive-stage small cell lung cancer (esSCLC) among elderly patients in the United States. While abundant data a...

Sudeep J Karve; Gregory L Price; Keith L Davis…

2014-11-01T23:59:59.000Z

114

Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung  

DOE Patents [OSTI]

A method is described for using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with [sup 67]Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the lungs by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the [sup 67]Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass. 1 figure.

Cole, D.A.; Moody, D.C. III; Ellinwood, L.E.; Klein, M.G.

1992-11-10T23:59:59.000Z

115

Fruit and Vegetable Consumption and Incidence of Gastric Cancer: A Prospective Study  

Science Journals Connector (OSTI)

...and intakes of total energy, alcohol, and processed...supplement use, and consumption of red meat, poultry...suggest that frequent consumption of vegetables may reduce...to increase vegetable consumption. 1 Parkin DM, Bray...55:74-108. 2 World Cancer Research Fund...

Susanna C. Larsson; Leif Bergkvist; and Alicja Wolk

2006-10-01T23:59:59.000Z

116

Prospective Study of UV Exposure and Cancer Incidence Among Swedish Women  

Science Journals Connector (OSTI)

...of Public Health, Boston, Massachusetts; and 8 Department of Community...needed to define the amount of solar or artificial UV exposure that...Cancer (IARC) concluded that solar UV exposure is the main environmental...their vitamin D requirement. Solar UVB exposure is indeed the...

Ling Yang; Marit B. Veierød; Marie Löf; Sven Sandin; Hans-Olov Adami; and Elisabete Weiderpass

2011-07-01T23:59:59.000Z

117

Dietary Glycemic Index, Glycemic Load, and Risk of Incident Breast Cancer in Postmenopausal Women  

Science Journals Connector (OSTI)

...prospectively with adequate power, while controlling for...relationship between glycemic load or index and breast cancer...estimates for glycemic load and index that were similar...is some evidence in our data that glycemic load and index are differentially...

Carolyn R. Jonas; Marjorie L. McCullough; Lauren R. Teras; Kimberly A. Walker-Thurmond; Michael J. Thun; and Eugenia E. Calle

2003-06-01T23:59:59.000Z

118

Prospective Study of UV Exposure and Cancer Incidence Among Swedish Women  

Science Journals Connector (OSTI)

...needed to define the amount of solar or artificial UV exposure that...Cancer (IARC) concluded that solar UV exposure is the main environmental...Thus there was evidence that solar or artificial UV exposure...in a case-control study in Canada in relation to age at exposure...

Ling Yang; Marit B. Veierød; Marie Löf; Sven Sandin; Hans-Olov Adami; and Elisabete Weiderpass

2011-07-01T23:59:59.000Z

119

Incident Invasive Breast Cancer, Geographic Location of Residence, and Reported Average Time Spent Outside  

Science Journals Connector (OSTI)

...baseline; and (c) clinic center solar irradiance. Hazard ratios and...life, baseline residence, or solar irradiance measured in Langelys...mortality in the United States and Canada. J Natl Cancer Inst 1997...ecologic study of dietary and solar ultraviolet-B links to breast...

Amy E. Millen; Mary Pettinger; Jo L. Freudenheim; Robert D. Langer; Carol A. Rosenberg; Yasmin Mossavar-Rahmani; Christine M. Duffy; Dorothy S. Lane; Anne McTiernan; Lewis H. Kuller; Ana Maria Lopez; and Jean Wactawski-Wende

2009-02-01T23:59:59.000Z

120

Evaluating serum anti-cyclin B1 antibodies as a biomarker for prevalent, early lung cancer in a population at high-risk for lung cancer  

Science Journals Connector (OSTI)

...postmenopausal women at increased risk for breast cancer in the NCIC...on bone loss in women at high risk for breast cancer, within a...postmenopausal women at increased risk of developing breast cancer...Eligible women had to have an acceptable quality BMD scan by DEXA taken...

Ann Marie Egloff; Joel Weissfeld; Stephanie R. Land; and Olivera J. Finn

2006-04-15T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Dosimetric comparison of treatment plans based on free breathing, maximum, and average intensity projection CTs for lung cancer SBRT  

SciTech Connect (OSTI)

Purpose: To determine whether there is a CT dataset may be more favorable for planning and dose calculation by comparing dosimetric characteristics between treatment plans calculated using free breathing (FB), maximum and average intensity projection (MIP and AIP, respectively) CTs for lung cancer patients receiving stereotactic body radiation therapy (SBRT). Methods: Twenty lung cancer SBRT patients, treated on a linac with 2.5 mm width multileaf-collimator (MLC), were analyzed retrospectively. Both FB helical and four-dimensional CT scans were acquired for each patient. Internal target volume (ITV) was delineated based on MIP CTs and modified based on both ten-phase datasets and FB CTs. Planning target volume (PTV) was then determined by adding additional setup margin to ITV. The PTVs and beams in the optimized treatment plan based on FB CTs were copied to MIP and AIP CTs, with the same isocenters, MLC patterns and monitor units. Mean effective depth (MED) of beams, and some dosimetric parameters for both PTVs and most important organ at risk (OAR), lung minus PTV, were compared between any two datasets using two-tail paired t test. Results: The MEDs in FB and AIP plans were similar but significantly smaller (Ps < 0.001) than that in MIP plans. Minimum dose, mean dose, dose covering at least 90% and 95% of PTVs in MIP plans were slightly higher than two other plans (Ps < 0.008). The absolute volume of lung minus PTV receiving greater than 5, 10, and 20 Gy in MIP plans were significantly smaller than those in both FB and AIP plans (Ps < 0.008). Conformity index for FB plans showed a small but statistically significantly higher. Conclusions: Dosimetric characteristics of AIP plans are similar to those of FB plans. Slightly better target volume coverage and significantly lower low-dose region ({<=}30 Gy) in lung was observed in MIP plans. The decrease in low-dose region in lung was mainly caused by the change of lung volume contoured on two datasets rather than the differences of dose distribution between AIP and MIP plans. Compare with AIP datasets, FB datasets were more prone to significant image artifacts and MIP datasets may overestimate or underestimate the target volume when the target is closer to the denser tissue, so AIP seems favorable for planning and dose calculation for lung SBRT.

Tian Yuan; Wang Zhiheng; Ge Hong; Zhang Tian; Cai Jing; Kelsey, Christopher; Yoo, David; Yin Fangfang [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States) and Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science, Beijing 100021 (China); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 and Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou, Henan 450008 (China); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States)

2012-05-15T23:59:59.000Z

122

Risk analysis of thyroid cancer incidence after exposure in childhood in the most contaminated areas of Ukraine, Belarus, and Russia in comparison with other studies  

Science Journals Connector (OSTI)

The current knowledge about thyroid cancer induction due to 131I exposures during childhood is limited. Due to the low incidences observed, it was assumed that 131I is less effective in cancer induction by a factor of 3, if compared to external exposures. An increase of the thyroid cancer incidence among children and adolescents from the south-eastern Belorussian, the northern Ukrainian, and the western Russian oblasts after the reactor accident in Chernobyl is reported. As a result of the further improvement of the dose estimation methods, the individual exposure doses based on the results of direct thyroid activity measurement were recalculated, and the geographical pattern of age-dependent thyroid doses was analysed. These resulted in the re-assessment of collective doses and of thyroid cancer risk.

G. Goulko; M. Tronko; T. Bogdanova; K. Henrichs; I. Kayro; V. Shpak; M. Lassmann; Chr. Reiners

2006-01-01T23:59:59.000Z

123

Predictive Parameters of CyberKnife Fiducial-less (XSight Lung) Applicability for Treatment of Early Non-Small Cell Lung Cancer: A Single-Center Experience  

SciTech Connect (OSTI)

Purpose: To determine which parameters allow for CyberKnife fiducial-less tumor tracking in stereotactic body radiation therapy (SBRT) for early-stage non-small cell lung cancer. Methods and Materials: A total of 133 lung SBRT patients were preselected for direct soft-tissue tracking based on manufacturer recommendations (peripherally located tumors ?1.5 cm with a dense appearance) and staff experience. Patients underwent a tumor visualization test to verify adequate detection by the tracking system (orthogonal radiographs). An analysis of potential predictors of successful tumor tracking was conducted looking at: tumor stage, size, histology, tumor projection on the vertebral column or mediastinum, distance to the diaphragm, lung-to-soft tissue ratio, and patient body mass index. Results: Tumor visualization was satisfactory for 88 patients (66%) and unsatisfactory for 45 patients (34%). Median time to treatment start was 6 days in the success group (range, 2-18 days) and 15 days (range, 3-63 days) in the failure group. A stage T2 (P=.04), larger tumor size (volume of 15.3 cm{sup 3} vs 6.5 cm{sup 3} in success and failure group, respectively) (P<.0001), and higher tumor density (0.86 g/cm{sup 3} vs 0.79 g/cm{sup 3}) were predictive of adequate detection. There was a 63% decrease in failure risk with every 1-cm increase in maximum tumor dimension (relative risk for failure = 0.37, CI=0.23-0.60, P=.001). A diameter of 3.6 cm predicted a success probability of 80%. Histology, lung-to-soft tissue ratio, distance to diaphragm, patient's body mass index, and tumor projection on vertebral column and mediastinum were not found to be predictive of success. Conclusions: Tumor size, volume, and density were the most predictive factors of a successful XSight Lung tumor tracking. Tumors >3.5 cm have ?80% chance of being adequately visualized and therefore should all be considered for direct tumor tracking.

Bahig, Houda; Campeau, Marie-Pierre; Vu, Toni; Doucet, Robert; Béliveau Nadeau, Dominic [Radiation Oncology Department, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec (Canada); Fortin, Bernard [Radiation Oncology Department, Maisonneuve-Rosemont Hospital, Montréal, Quebec (Canada); Roberge, David; Lambert, Louise; Carrier, Jean-François [Radiation Oncology Department, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec (Canada); Filion, Edith, E-mail: edith.filion.chum@ssss.gouv.qc.ca [Radiation Oncology Department, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec (Canada)

2013-11-01T23:59:59.000Z

124

High frequency of K-ras codon 12 mutations in bronchoalveolar lavage fluid of patients at high risk for second primary lung cancer.  

Science Journals Connector (OSTI)

...lung cancer. | A high frequency of K-ras mutations...Cancer Research 479 High Frequency of K-ras Codon 12...ABSTRACT A high frequency of K-ras mutations...9610 Medical Center Drive, Rockville, MD 20850...specimens. Only a small, variable percent-age of bronchial...

F M Scott; R Modali; T A Lehman; M Seddon; K Kelly; E C Dempsey; V Wilson; M S Tockman; and J L Mulshine

1997-03-01T23:59:59.000Z

125

Evaluation of image guided motion management methods in lung cancer radiotherapy  

SciTech Connect (OSTI)

Purpose: To evaluate the accuracy and reliability of three target localization methods for image guided motion management in lung cancer radiotherapy. Methods: Three online image localization methods, including (1) 2D method based on 2D cone beam (CB) projection images, (2) 3D method using 3D cone beam CT (CBCT) imaging, and (3) 4D method using 4D CBCT imaging, have been evaluated using a moving phantom controlled by (a) 1D theoretical breathing motion curves and (b) 3D target motion patterns obtained from daily treatment of 3 lung cancer patients. While all methods are able to provide target mean position (MP), the 2D and 4D methods can also provide target motion standard deviation (SD) and excursion (EX). For each method, the detected MP/SD/EX values are compared to the analytically calculated actual values to calculate the errors. The MP errors are compared among three methods and the SD/EX errors are compared between the 2D and 4D methods. In the theoretical motion study (a), the dependency of MP/SD/EX error on EX is investigated with EX varying from 2.0 cm to 3.0 cm with an increment step of 0.2 cm. In the patient motion study (b), the dependency of MP error on target sizes (2.0 cm and 3.0 cm), motion patterns (four motions per patient) and EX variations is investigated using multivariant linear regression analysis. Results: In the theoretical motion study (a), the MP detection errors are ?0.2 ± 0.2, ?1.5 ± 1.1, and ?0.2 ± 0.2 mm for 2D, 3D, and 4D methods, respectively. Both the 2D and 4D methods could accurately detect motion pattern EX (error < 1.2 mm) and SD (error < 1.0 mm). In the patient motion study (b), MP detection error vector (mm) with the 2D method (0.7 ± 0.4) is found to be significantly less than with the 3D method (1.7 ± 0.8,p < 0.001) and the 4D method (1.4 ± 1.0, p < 0.001) using paired t-test. However, no significant difference is found between the 4D method and the 3D method. Based on multivariant linear regression analysis, the variances of MP error in SI direction explained by target sizes, motion patterns, and EX variations are 9% with the 2D method, 74.4% with the 3D method, and 27% with the 4D method. The EX/SD detection errors are both < 1.0 mm for the 2D method and < 2.0 mm for the 4D method. Conclusions: The 2D method provides the most accurate MP detection regardless of the motion pattern variations, while its performance is limited by the accuracy of target identification in the projection images. The 3D method causes the largest error in MP determination, and its accuracy significantly depends on target sizes, motion patterns, and EX variations. The 4D method provides moderate MP detection results, while its accuracy relies on a regular motion pattern. In addition, the 2D and 4D methods both provide accurate measurement of the motion SD/EX, providing extra information for motion management.

Zhuang, Ling [Department of Radiation Oncology, Wayne State University School of Medicine, 4100 John R, Detroit, Michigan 48201 (United States)] [Department of Radiation Oncology, Wayne State University School of Medicine, 4100 John R, Detroit, Michigan 48201 (United States); Yan, Di; Liang, Jian; Ionascu, Dan; Mangona, Victor; Yang, Kai; Zhou, Jun, E-mail: jun.zhou@beaumont.edu [Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, Michigan 48073 (United States)] [Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, Michigan 48073 (United States)

2014-03-15T23:59:59.000Z

126

Postoperative Radiotherapy for Lung Cancer: Improvement in Locoregional Control Using Three-Dimensional Compared With Two-Dimensional Technique  

SciTech Connect (OSTI)

Purpose: To determine whether lung cancer patients treated with three-dimensional (3D) postoperative radiotherapy (PORT) have more favorable outcomes than those treated with two-dimensional (2D) PORT. Patients and Methods: We retrospectively analyzed the charts of 153 lung cancer patients who underwent PORT with curative intent at our center between 1995 and 2007. The patients were grouped according to the RT technique; 66 patients were in the 2D group and 87 in the 3D group. The outcomes included locoregional control, survival, and secondary effects. All patients were treated using a linear accelerator at a total dose of approximately 50 Gy and 2 Gy/fraction. A few patients (21%) also received chemotherapy. Most tumors were in the advanced stage, either Stage II (30%) or Stage III (65%). The main clinical indications for PORT were positive resection margins (23%) and Stage pN2 (52%) and pN1 (22%). The patient characteristics were comparable in both groups. Results: Kaplan-Meier analysis showed that the 3D technique significantly improved the locoregional control rate at 5 years compared with the 2D technique (81% vs. 56%, p = .007 [Cox]). The 2D technique was associated with a more than twofold increased risk of locoregional recurrence (hazard ratio, 2.7; 95% confidence interval, 1.3-5.5; p = .006). The overall survival rate did not differ at 5 years (38% vs. 20%, p = .3 [Cox]). The toxicities were also similar and acceptable in both groups. Conclusion: The 3D technique for conformal PORT for lung cancer improved the locoregional control rates of patients compared with the 2D technique.

Masson-Cote, Laurence [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-L'Hotel-Dieu de Quebec, Quebec City, QC (Canada); Couture, Christian [Departments of Anatomic Pathology and Cytology, Institut Universitaire de Cardiologie et de Pneumologie de Quebec (Hopital Laval), Quebec City, QC (Canada); Fortin, Andre [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-L'Hotel-Dieu de Quebec, Quebec City, QC (Canada); Dagnault, Anne, E-mail: anne.dagnault@mail.chuq.qc.ca [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-L'Hotel-Dieu de Quebec, Quebec City, QC (Canada)

2011-07-01T23:59:59.000Z

127

The development of a sensitive method to study volatile organic compounds in gaseous emissions of lung cancer cell lines  

E-Print Network [OSTI]

HCO3 producing excess H+ ions in the medium and therefore a fall in pH. This is seen as a color change. 10 When the confluence has reached 90% the cells are ready to be sub-cultured (Fig 2). 50 % cells in media Thawed... patients with no prior treatment for lung cancer. We have used an alternative method for the spectrometric analysis and quantitation of the selected chemical markers. The pre-concentration method involved a Purge and Trap unit with a thermal desorber...

Maroly, Anupam

2005-08-29T23:59:59.000Z

128

Abstract 354: Nuclear receptor expression atlas: A theragnostic targets for lung cancer patients  

Science Journals Connector (OSTI)

...Republic of. Introduction: The nuclear receptor (NR) superfamily...publicly available 129 microarray datasets. Results and Conclusions...quantitative real-time PCR to study nuclear receptor (NR) expression...two independent microarray datasets derived from 559 resected lung...

Yangsik Jeong; Yang Xie; Guanghua Xiao; Luc Girard; Woochang Lee; Carmen Behrens; Ignacio I. Wistuba; John D. Minna; and David J. Mangelsdorf

2011-04-15T23:59:59.000Z

129

A DRD1 Polymorphism Predisposes to Lung Cancer among Those Exposed to Secondhand Smoke during Childhood  

Science Journals Connector (OSTI)

...mediate reward, and thus reinforcing the effects of nicotine (14). Gene-environment interactions with indoor air pollution, exposure to SHS during adulthood, and exposure to SHS during childhood have also been reported to modulate lung...

Ana I. Robles; Ping Yang; Jin Jen; Andrew C. McClary; Kara Calhoun; Elise D. Bowman; Kirsi Vähäkangas; K. Leigh Greathouse; Yi Wang; Susan Olivo-Marston; Angela S. Wenzlaff; Bo Deng; Ann G. Schwartz; and Bríd M. Ryan

2014-12-01T23:59:59.000Z

130

Increased Lung and Bladder Cancer Incidence in Adults after In Utero and Early-Life Arsenic Exposure  

Science Journals Connector (OSTI)

...Liaw 1 Viviana Duran 8 Susana Cuevas 9 Jose Garcia 10 Rodrigo Meza 11 Rodrigo Valdes 12 Gustavo Valdes 12 Hugo Benitez 13 Vania...Health Perspect 2011;119:11-9. 32. Dean W , Santos F, Reik W.Epigenetic reprogramming in early mammalian...

Craig Steinmaus; Catterina Ferreccio; Johanna Acevedo; Yan Yuan; Jane Liaw; Viviana Durán; Susana Cuevas; José García; Rodrigo Meza; Rodrigo Valdés; Gustavo Valdés; Hugo Benítez; Vania VanderLinde; Vania Villagra; Kenneth P. Cantor; Lee E. Moore; Saida G. Perez; Scott Steinmaus; and Allan H. Smith

2014-08-01T23:59:59.000Z

131

Associations between Beer, Wine, and Liquor Consumption and Lung Cancer Risk: A Meta-analysis  

Science Journals Connector (OSTI)

...particularly risk at high consumption levels. (Cancer...cancer deaths in the world. Although tobacco...Alcoholic beverage consumption has been established...adjusted for total energy intake and consumption of fruits and vegetables...

Chun Chao

2007-11-01T23:59:59.000Z

132

Ordered Subset Analysis Identifies Loci Influencing Lung Cancer Risk on Chromosomes 6q and 12q  

Science Journals Connector (OSTI)

...environmental factors including tobacco smoke, radon gas, asbestos, arsenic, and some forms...American Cancer Society.; 2009. 2. International Agency for Research on Cancer (IARC...Islands Genetic African American Registry (Project SuGAR).Diabetes 2009;58(1...

Shenying Fang; Susan M. Pinney; Joan E. Bailey-Wilson; Mariza A. de Andrade; Yafang Li; Elena Kupert; Ming You; Ann G. Schwartz; Ping Yang; Marshall W. Anderson; and Christopher I. Amos

2010-12-01T23:59:59.000Z

133

Noninvasive Urinary Metabolomic Profiling Identifies Diagnostic and Prognostic Markers in Lung Cancer  

Science Journals Connector (OSTI)

...a phosphocreatine, an important energy reserve, have been observed in patients...addition, cancer cells have a higher energy requirement compared with quiescent...3. Boyle P, LB , editor. The World Cancer Report 2008. Lyon, France...

Ewy A. Mathé; Andrew D. Patterson; Majda Haznadar; Soumen K. Manna; Kristopher W. Krausz; Elise D. Bowman; Peter G. Shields; Jeffrey R. Idle; Philip B. Smith; Katsuhiro Anami; Dickran G. Kazandjian; Emmanuel Hatzakis; Frank J. Gonzalez; and Curtis C. Harris

2014-06-15T23:59:59.000Z

134

Role of MMP2, MMP3 and MMP9 in the development of breast cancer brain and lung metastasis in a syngeneic rat model  

E-Print Network [OSTI]

In order to study the expression of MMP2, MMP 3 and MMP9 in breast cancer brain and lung metastasis, we used a syngeneic rat model of distant metastasis of ENU1564, a carcinogen-induced mammary adenocarcinoma cell line. At six weeks post inoculation...

Mendes, Odete Rodrigues

2005-11-01T23:59:59.000Z

135

miR141–CXCL1–CXCR2 Signaling–Induced Treg Recruitment Regulates Metastases and Survival of Non–Small Cell Lung Cancer  

Science Journals Connector (OSTI)

...lung cancer cells, whereas the luciferase test confirmed that CXCL1 is a target of miR141...by the Student Newman-Keuls post hoc test. Comparisons between paired or unpaired two groups were performed using the Student t test. Spearman correlation was used to test...

Mingming Lv; Yujun Xu; Ruijing Tang; Jing Ren; Sunan Shen; Yueqiu Chen; Baorui Liu; Yayi Hou; Tingting Wang

2014-12-01T23:59:59.000Z

136

Assessing Respiration-Induced Tumor Motion and Internal Target Volume Using Four-Dimensional Computed Tomography for Radiotherapy of Lung Cancer  

SciTech Connect (OSTI)

Purpose: To assess three-dimensional tumor motion caused by respiration and internal target volume (ITV) for radiotherapy of lung cancer. Methods and Materials: Respiration-induced tumor motion was analyzed for 166 tumors from 152 lung cancer patients, 57.2% of whom had Stage III or IV non-small-cell lung cancer. All patients underwent four-dimensional computed tomography (4DCT) during normal breathing before treatment. The expiratory phase of 4DCT images was used as the reference set to delineate gross tumor volume (GTV). Gross tumor volumes on other respiratory phases and resulting ITVs were determined using rigid-body registration of 4DCT images. The association of GTV motion with various clinical and anatomic factors was analyzed statistically. Results: The proportions of tumors that moved >0.5 cm along the superior-inferior (SI), lateral, and anterior-posterior (AP) axes during normal breathing were 39.2%, 1.8%, and 5.4%, respectively. For 95% of the tumors, the magnitude of motion was less than 1.34 cm, 0.40 cm, and 0.59 cm along the SI, lateral, and AP directions. The principal component of tumor motion was in the SI direction, with only 10.8% of tumors moving >1.0 cm. The tumor motion was found to be associated with diaphragm motion, the SI tumor location in the lung, size of the GTV, and disease T stage. Conclusions: Lung tumor motion is primarily driven by diaphragm motion. The motion of locally advanced lung tumors is unlikely to exceed 1.0 cm during quiet normal breathing except for small lesions located in the lower half of the lung.

Liu, H. Helen [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)]. E-mail: hliu@mdanderson.org; Balter, Peter [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Tutt, Teresa [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Choi, Bum [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Zhang, Joy [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Wang, Catherine [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Chi, Melinda [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Luo Dershan [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Pan Tinsu [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Hunjan, Sandeep [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Starkschall, George [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Rosen, Isaac [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Prado, Karl [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Liao Zhongxing; Chang, Joe; Komaki, Ritsuko; Cox, James D. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Mohan, Radhe; Dong Lei [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

2007-06-01T23:59:59.000Z

137

In Vitro Photodynamic Therapy of Human Lung Cancer: Investigation of Dose-Rate Effects  

Science Journals Connector (OSTI)

...observed at equal light energies (225 mj/ cm2). The...X-ray view box (General Electric, Milwaukee, WI; daylight...exposed to the highest energies using a thermister probe...therapy of a human lung car cinoma line. Although...of time and treatment energy, however, was not addressed...

Wilbert Matthews; John Cook; James B. Mitchell; Roger R. Perry; Steven Evans; and Harvey I. Pass

1989-04-01T23:59:59.000Z

138

Changes in Nonmelanoma Skin Cancer Incidence between 1977–1978 and 1998–1999 in Northcentral New Mexico  

Science Journals Connector (OSTI)

...follow-up survey of NMSC in New Mexico and report here incidence rate...three-county area in northcentral New Mexico for two 12-month time periods...the highest levels of ambient solar UV radiation. Subsequent surveys...the resident population of New Mexico. Incidence rates in New Mexico...

William F. Athas; William C. Hunt; and Charles R. Key

2003-10-01T23:59:59.000Z

139

Sequence Variation in Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease Gene, Low LDL Cholesterol, and Cancer Incidence  

Science Journals Connector (OSTI)

...pharmacologically might modestly increase cancer risk (4, 5...statins does not seem to increase cancer risk (6-8...cholesterol levels may increase cancer risk is to compare...usual consumption of wine, beer, and hard liquor...uses a 5 blind replicate quality assurance program for...

Aaron R. Folsom; James M. Peacock; and Eric Boerwinkle

2007-11-01T23:59:59.000Z

140

On the possible benefits of a hybrid VMAT technique in the treatment of non–small cell lung cancer  

SciTech Connect (OSTI)

To assess, using clinical cases, the potential of a hybrid technique for the treatment of non–small cell lung cancer (NSCLC)-blending volumetric-modulated arc therapy (VMAT) and conformal radiation therapy (CRT) fields, and to consider potential issues with implementation of such a technique. Eight clinical cases already treated with CRT were used for a planning study comparing target coverage and organs at risk (OAR) sparing between CRT and hybrid VMAT (VMATh). Quality assurance (QA) implications of the resultant hybrid plans are discussed. The hybrid technique resulted in superior target conformity or improved sparing of OAR or both. The hybrid technique shows promise, but the QA implications of motion at treatment need careful consideration.

Agapito, John, E-mail: john_agapito@wrh.on.ca

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Helical Tomotherapy Planning for Lung Cancer Based on Ventilation Magnetic Resonance Imaging  

SciTech Connect (OSTI)

To investigate the feasibility of lung ventilation-based treatment planning, computed tomography and hyperpolarized (HP) helium-3 (He-3) magnetic resonance imaging (MRI) ventilation images of 6 subjects were coregistered for intensity-modulated radiation therapy planning in Tomotherapy. Highly-functional lungs (HFL) and less-functional lungs (LFL) were contoured based on their ventilation image intensities, and a cylindrical planning-target-volume was simulated at locations adjacent to both HFL and LFL. Annals of an anatomy-based plan (Plan 1) and a ventilation-based plan (Plan 2) were generated. The following dosimetric parameters were determined and compared between the 2 plans: percentage of total/HFL volume receiving {>=}20 Gy, 15 Gy, 10 Gy, and 5 Gy (TLV{sub 20}, HFLV{sub 20}, TLV{sub 15}, HFLV{sub 15}, TLV{sub 10}, HFLV{sub 10}, TLV{sub 5}, HFLV{sub 5}), mean total/HFL dose (MTLD/HFLD), maximum doses to all organs at risk (OARs), and target dose conformality. Compared with Plan 1, Plan 2 reduced mean HFLD (mean reduction, 0.8 Gy), MTLD (mean reduction, 0.6 Gy), HFLV{sub 20} (mean reduction, 1.9%), TLV{sub 20} (mean reduction, 1.5%), TLV{sub 15} (mean reduction, 1.7%), and TLV{sub 10} (mean reduction, 2.1%). P-values of the above comparisons are less than 0.05 using the Wilcoxon signed rank test. For HFLV{sub 15}, HFLV{sub 10}, TLV{sub 5}, and HTLV{sub 5}, Plan 2 resulted in lower values than plan 1 but the differences are not significant (P-value range, 0.063-0.219). Plan 2 did not significantly change maximum doses to OARs (P-value range, 0.063-0.563) and target conformality (P = 1.000). HP He-3 MRI of patients with lung disease shows a highly heterogeneous ventilation capacity that can be utilized for functional treatment planning. Moderate but statistically significant improvements in sparing functional lungs were achieved using helical tomotherapy plans.

Cai Jing; McLawhorn, Robert [Department of Radiation Oncology, University of Virginia, Charlottesville, VA (United States); Altes, Tallisa A.; Lange, Eduard de [Department of Radiology, University of Virginia, Charlottesville, VA (United States); Read, Paul W.; Larner, James M.; Benedict, Stanley H. [Department of Radiation Oncology, University of Virginia, Charlottesville, VA (United States); Sheng Ke, E-mail: ks2mc@virginia.edu [Department of Radiation Oncology, University of Virginia, Charlottesville, VA (United States)

2011-01-01T23:59:59.000Z

142

Progressive Genomic Instability in the FVB/Kras[superscript LA2] Mouse Model of Lung Cancer  

E-Print Network [OSTI]

Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations ...

Jacks, Tyler E.

143

Abstract LB-521: Expression profile of nuclear receptor superfamily in a lung cancer pathogenesis model  

Science Journals Connector (OSTI)

...Abstract 2296: Identification of novel nuclear receptor targets in estrogen receptor...subtype. Aims and Methods: To identify nuclear receptor (NR) targets, we did microarray...using previously published breast cancer datasets. Results and Conclusion: The 41 NRs...

Yangsik Jeong; Jihye Kim; Mitsuo Sato; Woochang Lee; Woochang Lee; Jonathan M. Kurie; John D. Minna; and David J. Mangelsdorf

2012-04-15T23:59:59.000Z

144

Vegetables, Fruit, and Lung Cancer in the Iowa Women's Health Study  

Science Journals Connector (OSTI)

...65-69, 70-74), total energy (quartile), education...ginger, kelp and seaweeds Dark green leafy vegetables...0-118.5 118.6 Dark green leafy vegetables...Q2 Q3 Q4 (high) Total energy, kcal Male (M) 2157...in Japan. Analysis of survey data on incidence in Aomori...

Kristi A. Steinmetz; John D. Potter; and Aaron R. Folsom

1993-02-01T23:59:59.000Z

145

Association between thyroid cancer incidence and the distance from nuclear power plants in the U.S.  

E-Print Network [OSTI]

??Concerns have been widespread that living near nuclear power plants might increase the risk of cancer in surrounding communities. Nuclear power generation is still the… (more)

Watase, Hiroko

2012-01-01T23:59:59.000Z

146

GIS Based Study of Probable Causes of Increase in Cancer Incidences in Iraq After Gulf War 1991.  

E-Print Network [OSTI]

?? The use of banned toxic weapons in Iraq during Gulf War 1991 started new debates. The increase in cancer cases was the main focus… (more)

Muhammad, Hassan

2006-01-01T23:59:59.000Z

147

E-Print Network 3.0 - a549 lung adenocarcinoma Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Mathematics 48 TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors Summary: TP53 gene mutations of lung cancer...

148

E-Print Network 3.0 - agricultural lung diseases Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biology and Medicine 18 TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors Summary: TP53 gene mutations of lung cancer...

149

Correlation of Clinical and Dosimetric Factors With Adverse Pulmonary Outcomes in Children After Lung Irradiation  

SciTech Connect (OSTI)

Purpose: To identify the incidence and the risk factors for pulmonary toxicity in children treated for cancer with contemporary lung irradiation. Methods and Materials: We analyzed clinical features, radiographic findings, pulmonary function tests, and dosimetric parameters of children receiving irradiation to the lung fields over a 10-year period. Results: We identified 109 patients (75 male patients). The median age at irradiation was 13.8 years (range, 0.04-20.9 years). The median follow-up period was 3.4 years. The median prescribed radiation dose was 21 Gy (range, 0.4-64.8 Gy). Pulmonary toxic chemotherapy included bleomycin in 58.7% of patients and cyclophosphamide in 83.5%. The following pulmonary outcomes were identified and the 5-year cumulative incidence after irradiation was determined: pneumonitis, 6%; chronic cough, 10%; pneumonia, 35%; dyspnea, 11%; supplemental oxygen requirement, 2%; radiographic interstitial lung disease, 40%; and chest wall deformity, 12%. One patient died of progressive respiratory failure. Post-irradiation pulmonary function tests available from 44 patients showed evidence of obstructive lung disease (25%), restrictive disease (11%), hyperinflation (32%), and abnormal diffusion capacity (12%). Thoracic surgery, bleomycin, age, mean lung irradiation dose (MLD), maximum lung dose, prescribed dose, and dosimetric parameters between V{sub 22} (volume of lung exposed to a radiation dose ?22 Gy) and V{sub 30} (volume of lung exposed to a radiation dose ?30 Gy) were significant for the development of adverse pulmonary outcomes on univariate analysis. MLD, maximum lung dose, and V{sub dose} (percentage of volume of lung receiving the threshold dose or greater) were highly correlated. On multivariate analysis, MLD was the sole significant predictor of adverse pulmonary outcome (P=.01). Conclusions: Significant pulmonary dysfunction occurs in children receiving lung irradiation by contemporary techniques. MLD rather than prescribed dose should be used to perform risk stratification of patients receiving lung irradiation.

Venkatramani, Rajkumar, E-mail: rvenkatramani@chla.usc.edu [Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California (United States); Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Kamath, Sunil [Department of Pulmonology, Children's Hospital Los Angeles, Los Angeles, California (United States); Wong, Kenneth [Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California (United States); Olch, Arthur J. [Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California (United States); Department of Radiation Oncology, University of Southern California, Los Angeles, California (United States); Malvar, Jemily [Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Sposto, Richard [Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California (United States); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Goodarzian, Fariba [Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California (United States); Freyer, David R. [Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California (United States); Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Keens, Thomas G. [Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Department of Pulmonology, Children's Hospital Los Angeles, Los Angeles, California (United States); and others

2013-08-01T23:59:59.000Z

150

Critical Appraisal of Acuros XB and Anisotropic Analytic Algorithm Dose Calculation in Advanced Non-Small-Cell Lung Cancer Treatments  

SciTech Connect (OSTI)

Purpose: To assess the clinical impact of the Acuros XB algorithm (implemented in the Varian Eclipse treatment-planning system) in non-small-cell lung cancer (NSCLC) cases. Methods and Materials: A CT dataset of 10 patients presenting with advanced NSCLC was selected and contoured for planning target volume, lungs, heart, and spinal cord. Plans were created for 6-MV and 15-MV beams using three-dimensional conformal therapy, intensity-modulated therapy, and volumetric modulated arc therapy with RapidArc. Calculations were performed with Acuros XB and the Anisotropic Analytical Algorithm. To distinguish between differences coming from the different heterogeneity management and those coming from the algorithm and its implementation, all the plans were recalculated assigning Hounsfield Unit (HU) = 0 (Water) to the CT dataset. Results: Differences in dose distributions between the two algorithms calculated in Water were <0.5%. This suggests that the differences in the real CT dataset can be ascribed mainly to the different heterogeneity management, which is proven to be more accurate in the Acuros XB calculations. The planning target dose difference was stratified between the target in soft tissue, where the mean dose was found to be lower for Acuros XB, with a range of 0.4% {+-} 0.6% (intensity-modulated therapy, 6 MV) to 1.7% {+-} 0.2% (three-dimensional conformal therapy, 6 MV), and the target in lung tissue, where the mean dose was higher for 6 MV (from 0.2% {+-} 0.2% to 1.2% {+-} 0.5%) and lower for 15 MV (from 0.5% {+-} 0.5% to 2.0% {+-} 0.9%). Mean doses to organs at risk presented differences up to 3% of the mean structure dose in the worst case. No particular or systematic differences were found related to the various modalities. Calculation time ratios between calculation time for Acuros XB and the Anisotropic Analytical Algorithm were 7 for three-dimensional conformal therapy, 5 for intensity-modulated therapy, and 0.2 for volumetric modulated arc therapy with RapidArc. Conclusion: The availability of Acuros XB could improve patient dose estimation, increasing the data consistency of clinical trials.

Fogliata, Antonella, E-mail: afc@iosi.ch [Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona (Switzerland)] [Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Nicolini, Giorgia; Clivio, Alessandro; Vanetti, Eugenio; Cozzi, Luca [Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona (Switzerland)] [Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona (Switzerland)

2012-08-01T23:59:59.000Z

151

Increased Protein Turnover Despite Normal Energy Metabolism and Responses to Feeding in Patients with Lung Cancer  

Science Journals Connector (OSTI)

...for assessing rates of energy expenditure, nutrient...responses of protein and energy metabolism to food intake...composition, assessed by measurements of body water content...the thoracic surgical unit. All subjects were ambulant...Joint 1125 PROTEIN AND ENERGY METABOLISM IN CANCER...

Sheila Melville; Margaret A. McNurlan; A. Graham Calder; and Peter J. Garlick

1990-02-15T23:59:59.000Z

152

Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies  

Science Journals Connector (OSTI)

...adjustment for tobacco use and radon exposure (53) . There is...previously found in the Pooling Project a nonsignificant 12% reduction...statistical expertise in the Pooling Project. 1 World Cancer Research Fund...Van Holten V., Muir C. . International Classification of Diseases...

Satu Männistö; Stephanie A. Smith-Warner; Donna Spiegelman; Demetrius Albanes; Kristin Anderson; Piet A. van den Brandt; James R. Cerhan; Graham Colditz; Diane Feskanich; Jo L. Freudenheim; Edward Giovannucci; R. Alexandra Goldbohm; Saxon Graham; Anthony B. Miller; Thomas E. Rohan; Jarmo Virtamo; Walter C. Willett; and David J. Hunter

2004-01-01T23:59:59.000Z

153

Abstract 5752: Molecular mechanisms driving oncogenesis in KRAS mutant non-small cell lung cancer  

Science Journals Connector (OSTI)

...harboring KRAS mutations (20-30% frequency) has highlighted the need for RAS targeted...demonstrates that KRAS mutated cancer cells show variable responses to inhibition of downstream...molecular mechanisms through which KRAS drives oncogenesis have yet to be fully elucidated...

Matthew Holderfield; Frank McCormick; and Tobi Nagel

2011-01-10T23:59:59.000Z

154

Cancer Incidence and Mortality during the Intervention and Postintervention Periods of the Women's Health Initiative Dietary Modification Trial  

Science Journals Connector (OSTI)

...intervention involving reduced total fat (20% energy) would reduce incidence of these outcomes...04) between the baseline percentage of energy from fat as measured by 4-day food records...reported relatively higher percentage of energy from dietary fat at baseline made larger...

Cynthia A. Thomson; Linda Van Horn; Bette J. Caan; Aaron K. Aragaki; Rowan T. Chlebowski; JoAnn E. Manson; Thomas E. Rohan; Lesley F. Tinker; Lewis H. Kuller; Lifang Hou; Dorothy S. Lane; Karen C. Johnson; Mara Z. Vitolins; Ross L. Prentice

2014-12-01T23:59:59.000Z

155

Prospective detection of preclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression.  

Science Journals Connector (OSTI)

...Johns Hopkins Lung Project. sures to tobacco smoke, radon, and arsenic, whose...Johns Hopkins Lung Project. upon which our...The relation of radon exposure and tobacco...Mountain. C. F. A new international staging system for...

M S Tockman; J L Mulshine; S Piantadosi; Y S Erozan; P K Gupta; J C Ruckdeschel; P R Taylor; T Zhukov; W H Zhou; Y L Qiao; and S X Yao

1997-12-01T23:59:59.000Z

156

Stereotactic Body Radiotherapy (SBRT) for Operable Stage I Non-Small-Cell Lung Cancer: Can SBRT Be Comparable to Surgery?  

SciTech Connect (OSTI)

Purpose: To review treatment outcomes for stereotactic body radiotherapy (SBRT) in medically operable patients with Stage I non-small-cell lung cancer (NSCLC), using a Japanese multi-institutional database. Patients and Methods: Between 1995 and 2004, a total of 87 patients with Stage I NSCLC (median age, 74 years; T1N0M0, n = 65; T2N0M0, n = 22) who were medically operable but refused surgery were treated using SBRT alone in 14 institutions. Stereotactic three-dimensional treatment was performed using noncoplanar dynamic arcs or multiple static ports. Total dose was 45-72.5 Gy at the isocenter, administered in 3-10 fractions. Median calculated biological effective dose was 116 Gy (range, 100-141 Gy). Data were collected and analyzed retrospectively. Results: During follow-up (median, 55 months), cumulative local control rates for T1 and T2 tumors at 5 years after SBRT were 92% and 73%, respectively. Pulmonary complications above Grade 2 arose in 1 patient (1.1%). Five-year overall survival rates for Stage IA and IB subgroups were 72% and 62%, respectively. One patient who developed local recurrences safely underwent salvage surgery. Conclusion: Stereotactic body radiotherapy is safe and promising as a radical treatment for operable Stage I NSCLC. The survival rate for SBRT is potentially comparable to that for surgery.

Onishi, Hiroshi, E-mail: honishi@yamanashi.ac.jp [School of Medicine, Yamanashi University, Yamanashi (Japan); Shirato, Hiroki [School of Medicine, Hokkaido University, Sapporo (Japan); Nagata, Yasushi [School of Medicine, Hiroshima University, Hiroshima (Japan); Hiraoka, Masahiro [School of Medicine, Kyoto University, Kyoto (Japan); Fujino, Masaharu [School of Medicine, Hokkaido University, Sapporo (Japan); School of Medicine, Yamanashi University, Yamanashi (Japan); Gomi, Kotaro [Cancer Institute Suwa Red-Cross Hospital, Suwa (Japan); Karasawa, Katsuyuki [Tokyo Metropolitan Komagome Hospital, Tokyo (Japan); Hayakawa, Kazushige; Niibe, Yuzuru [Kitasato University, Kanagawa (Japan); Takai, Yoshihiro [School of Medicine, Hirosaki University, Hirosaki (Japan); Kimura, Tomoki [School of Medicine, Kagawa University, Hiroshima (Japan); Takeda, Atsuya [Ofuna Chuo Hospital, Kanagawa (Japan); Ouchi, Atsushi [Keijinkai Hospital, Sapporo (Japan); Hareyama, Masato [Sapporo Medical University, Sapporo (Japan); Kokubo, Masaki [Institute of Biomedical Research and Innovation, Kobe (Japan); Kozuka, Takuyo [School of Cancer Institute Ariake Hospital, Tokyo (Japan); Arimoto, Takuro [Kitami Red Cross Hospital, Kitami (Japan); Hara, Ryusuke [National Institute of Radiological Science, Chiba (Japan); Itami, Jun [National Cancer Center, Tokyo (Japan); Araki, Tsutomu [School of Medicine, Yamanashi University, Yamanashi (Japan)

2011-12-01T23:59:59.000Z

157

Sprouty-4 Inhibits Transformed Cell Growth, Migration and Invasion, and Epithelial-Mesenchymal Transition, and Is Regulated by Wnt7A through PPAR? in Non–Small Cell Lung Cancer  

Science Journals Connector (OSTI)

...West J, Franklin W, et al. Altered HOX and WNT7A expression in human lung cancer. Proc Natl Acad Sci U S A 2000;97:12776-81. 55 Kirikoshi H , Katoh M. Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B...

Meredith A. Tennis; Michelle M. Van Scoyk; Scott V. Freeman; Katherine M. Vandervest; Raphael A. Nemenoff; Robert A. Winn

2010-06-01T23:59:59.000Z

158

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing  

E-Print Network [OSTI]

Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible for more than 500,000 deaths per year worldwide. Here, we report exome and genome sequences of 183 lung adenocarcinoma tumor/normal ...

Lander, Eric S.

159

Brachial Plexopathy in Apical Non-Small Cell Lung Cancer Treated With Definitive Radiation: Dosimetric Analysis and Clinical Implications  

SciTech Connect (OSTI)

Purpose: Data are limited on the clinical significance of brachial plexopathy in patients with apical non-small cell lung cancers (NSCLC) treated with definitive radiation therapy. We report the rates of radiation-induced brachial plexopathy (RIBP) and tumor-related brachial plexopathy (TRBP) and associated dosimetric parameters in apical NSCLC patients. Methods and Materials: Charts of NSCLC patients with primary upper lobe or superiorly located nodal disease who received {>=}50 Gy of definitive conventionally fractionated radiation or chemoradiation were retrospectively reviewed for evidence of brachial plexopathy and categorized as RIBP, TRBP, or trauma-related. Dosimetric data were gathered on ipsilateral brachial plexuses (IBP) contoured according to Radiation Therapy Oncology Group atlas guidelines. Results: Eighty patients were identified with a median follow-up and survival time of 17.2 and 17.7 months, respectively. The median prescribed dose was 66.6 Gy (range, 50.4-84.0), and 71% of patients received concurrent chemotherapy. RIBP occurred in 5 patients with an estimated 3-year rate of 12% when accounting for competing risk of death. Seven patients developed TRBP (estimated 3-year rate of 13%), comprising 24% of patients who developed locoregional failures. Grade 3 brachial plexopathy was more common in patients who experienced TRBP than RIBP (57% vs 20%). No patient who received {<=}78 Gy to the IBP developed RIBP. On multivariable competing risk analysis, IBP V76 receiving {>=}1 cc, and primary tumor failure had the highest hazard ratios for developing RIBP and TRBP, respectively. Conclusions: RIBP is a relatively uncommon complication in patients with apical NSCLC tumors receiving definitive doses of radiation, while patients who develop primary tumor failures are at high risk for developing morbid TRBP. These findings suggest that the importance of primary tumor control with adequate doses of radiation outweigh the risk of RIBP in this population of patients.

Eblan, Michael J.; Corradetti, Michael N.; Lukens, J. Nicholas; Xanthopoulos, Eric [Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States)] [Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States); Mitra, Nandita [Department of Biostatistics and Epidemiology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States)] [Department of Biostatistics and Epidemiology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States); Christodouleas, John P.; Grover, Surbhi; Fernandes, Annemarie T. [Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States)] [Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States); Langer, Corey J.; Evans, Tracey L.; Stevenson, James [Department of Medical Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States)] [Department of Medical Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States); Rengan, Ramesh [Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States)] [Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States); Apisarnthanarax, Smith, E-mail: apisarns@uphs.upenn.edu [Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States)] [Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (United States)

2013-01-01T23:59:59.000Z

160

Serum Fragment of Cytokeratin Subunit 19 Measured by CYFRA 21-1 Immunoradiometric Assay as a Marker of Lung Cancer  

Science Journals Connector (OSTI)

...cancer increased (P 0.01, Kruskal-Wallis test). This immunohistochemical...cancer increased (P Kruskal-Wallis test). This immunohistochemical...cancer in-creased (P Kruskal-Wallis test). This immunohisto-chemical...

Jean-Louis Pujol; Jean Grenier; Jean-Pierre Daurès; Alain Daver; Henri Pujol; François-Bernard Michel

1993-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

The Effect of a Contrast Agent on Proton Beam Range in Radiotherapy Planning Using Computed Tomography for Patients With Locoregionally Advanced Lung Cancer  

SciTech Connect (OSTI)

Purpose: We evaluated the effect of a contrast agent (CA) on proton beam range in a treatment planning system (TPS) for patients with locoregionally advanced lung cancer. Methods and Materials: Two sets of computed tomography (CT) images (with and without CA) were obtained from 20 patients with lung cancer. Because the increase in Hounsfield unit ( Increment HU) value of the heart and great vessels due to the effect of CA is most prominent among thoracic structures, to evaluate the effect of CA on proton beam range in the TPS, we compared the calculated distal ranges in the plan with CA-enhanced CT with those with corrected CT, in which the HU values of the heart and great vessels in the CA-enhanced CT were replaced by average HU values obtained from the unenhanced CT. Results: The mean Increment HU value and the longest length of the heart and great vessels within the proton beam path in the field that passed through these structures were 189 {+-} 29 HU (range, 110-250 HU) and 7.1 {+-} 1.1 cm (range, 2.6-11.2 cm), respectively. The mean distal range error in the TPS because of the presence of CA was 1.0 {+-} 0.7 cm (range, 0.2-2.6 cm). Conclusion: If CA-enhanced CT images are used for radiotherapy planning using a proton beam for the treatment of lung cancer, our results suggest that the HU values of the heart and great vessels should be replaced by the average HU values of soft tissue to avoid discrepancies between planned and delivered doses.

Hwang, Ui-Jung; Shin, Dong Ho [Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Kim, Tae Hyun, E-mail: k2onco@naver.com [Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Moon, Sung Ho; Lim, Young Kyung; Jeong, Hojin; Rah, Jeong-Eun; Kim, Sang Soo; Kim, Joo-Young; Kim, Dae Yong; Park, Sung Yong; Cho, Kwan Ho [Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of)

2011-11-15T23:59:59.000Z

162

Nondisruptive p53 Mutations Are Associated with Shorter Survival in Patients with Advanced Non–Small Cell Lung Cancer  

Science Journals Connector (OSTI)

...by grants from the San Antonio Cancer Institute, San Antonio, Texas (P30-CA54174) and the National Cancer Institute, Redes En Accion (U01-CA86117). Citation Information: Cancer Epidemiol Biomarkers Prev 2011;20(10 Suppl):PR1.

Miguel A. Molina-Vila; Jordi Bertran-Alamillo; Amaya Gascó; Clara Mayo-de-las-Casas; María Sánchez-Ronco; Laia Pujantell-Pastor; Laura Bonanno; Adolfo G. Favaretto; Andrés F. Cardona; Alain Vergnenègre; Margarita Majem; Bartomeu Massuti; Teresa Morán; Enric Carcereny; Santiago Viteri; Rafael Rosell

2014-09-01T23:59:59.000Z

163

An international evaluation of the cancer preventive potential of carotenoids.  

Science Journals Connector (OSTI)

...second volume of the IARC Handbooks of Cancer Prevention...beta-carotene not only does not prevent lung cancer...second volume of the IARC Handbooks of Cancer Prevention...beta-carotene not only does not prevent lung cancer...

H Vainio and M Rautalahti

1998-08-01T23:59:59.000Z

164

Variety in Fruit and Vegetable Consumption and the Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition  

Science Journals Connector (OSTI)

...Vegetable and fruit consumption has been hypothesized...cancer risk. The 2007 World Cancer Research Fund...vegetable and fruit consumption and energy intake increased with...fruit and vegetable consumption. Those reporting higher...

Frederike L. Büchner; H. Bas Bueno-de-Mesquita; Martine M. Ros; Kim Overvad; Christina C. Dahm; Louise Hansen; Anne Tjønneland; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Marina Touillaud; Rudolf Kaaks; Sabine Rohrmann; Heiner Boeing; Ute Nöthlings; Antonia Trichopoulou; Dimosthenis Zylis; Vardis Dilis; Domenico Palli; Sabina Sieri; Paolo Vineis; Rosario Tumino; Salvatore Panico; Petra H.M. Peeters; Carla H. van Gils; Eiliv Lund; Inger T. Gram; Tonje Braaten; María-José Sánchez; Antonio Agudo; Nerea Larrañaga; Eva Ardanaz; Carmen Navarro; Marcial V. Argüelles; Jonas Manjer; Elisabet Wirfält; Göran Hallmans; Torgny Rasmuson; Tim J. Key; Kay-Tee Khaw; Nick Wareham; Nadia Slimani; Anne-Claire Vergnaud; Wei W. Xun; Lambertus A.L.M. Kiemeney; and Elio Riboli

2010-09-01T23:59:59.000Z

165

Association of Energy Intake and Energy Balance with Postmenopausal Breast Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial  

Science Journals Connector (OSTI)

...13-6. 3 Willett WC. Fat, energy and breast cancer. J Nutr...den BT, van den Brandt PA. Energy restriction and the risk of...Zhu Z. Mechanisms by which energy restriction inhibits carcinogenesis...of diet and breast cancer in Argentina. Int J Cancer 1989;44...

Shih-Chen Chang; Regina G. Ziegler; Barbara Dunn; Rachael Stolzenberg-Solomon; James V. Lacey, Jr.; Wen-Yi Huang; Arthur Schatzkin; Douglas Reding; Robert N. Hoover; Patricia Hartge; and Michael F. Leitzmann

2006-02-01T23:59:59.000Z

166

Energy Intake and Risk of Postmenopausal Breast Cancer: An Expanded Analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort  

Science Journals Connector (OSTI)

...Zhu Z. Mechanisms by which energy restriction inhibits carcinogenesis...Zhu Z, Jiang W. Dietary energy restriction in breast cancer...133-42. 5 Kaaks R , Lukanova A. Energy balance and cancer: the role...the effect of World War II in Norway. Cancer Causes Control 1996...

Laura Y. Sue; Catherine Schairer; Xiaomei Ma; Craig Williams; Shih-Chen Chang; Anthony B. Miller; Catherine A. McCarty; Bradley J. Willcox; and Regina G. Ziegler

2009-11-01T23:59:59.000Z

167

E-Print Network 3.0 - assess lung dose Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

radiation-related lung cancer risks associated with annual low-dose... lung radiation dose from ... Source: Brenner, David Jonathan - Center for Radiological Research &...

168

E-Print Network 3.0 - a549 lung epithelial Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

PROLIFERATION AND PROTEIN EXPRESSION OF LUNG CANCER CELLS Summary: (NSCLC) cell lines. Methods: The epithelial lung carcinoma (A549 ) and a bronchioalveolar (NCI-H358......

169

Abstract CT238: Phase III randomized, placebo controlled trial of COX-2 inhibition in addition to standard chemotherapy for advanced non-small cell lung cancer (NSCLC):CALGB 30801 (Alliance)  

Science Journals Connector (OSTI)

...lung cancer (NSCLC):CALGB 30801 (Alliance) Martin J. Edelman 1 Xiaofei Wang 2...Friedman 12 Jon Ritter 13 Everett Vokes 12 Alliance for Clinical Trials in Oncology 1University...Friedman, Jon Ritter, Everett Vokes, Alliance for Clinical Trials in Oncology. Phase...

Martin J. Edelman; Xiaofei Wang; Lydia Hodgson; Richard T. Cheney; Maria Baggstrom; Thomas Sachdev; Ajeet Gajra; Erin Bertino; Karen Reckamp; Julian Molina; Joan Schiller; Kisha Mitchell-Richards; Paula Friedman; Jon Ritter; Everett Vokes; Alliance for Clinical Trials in Oncology

2014-10-01T23:59:59.000Z

170

Phase I Results of Vinorelbine With Concurrent Radiotherapy in Elderly Patients With Unresectable, Locally Advanced Non-Small-Cell Lung Cancer: West Japan Thoracic Oncology Group (WJTOG3005-DI)  

SciTech Connect (OSTI)

Purpose: To investigate the safety and efficacy of concurrent vinorelbine and thoracic radiotherapy in elderly patients with locally advanced non-small-cell lung cancer (NSCLC). Methods and Materials: Eligible patients were 71 years of age or older with unresectable Stage III NSCLC. Patients were treated with thoracic radiotherapy (60 Gy) and concurrent vinorelbine (20 mg/m{sup 2} in Level 1 and 25 mg/m{sup 2} in Level 2) on Days 1 and 8 every 3 weeks for two cycles, followed by adjuvant vinorelbine (25 mg/m{sup 2}) on Days 1 and 8 every 3 weeks for two cycles. Results: Four patients were enrolled at Level 1. One patient experienced Grade 3 febrile neutropenia at Level 1 and the dose was escalated to Level 2. At Level 2, 2 of 6 patients experienced dose-limiting toxicities (Grade 4 neutropenia in 1 patient and Grade 3 infection in another). Three of 6 patients developed late Grade 2 or 3 pneumonitis. Therefore, the dose was de-escalated to Level 1. An additional 6 patients were enrolled at Level 1, 4 of whom experienced dose-limiting toxicities (incomplete radiotherapy because of Grade 2 pneumonitis in 1 patient and Grade 3 infection in 1, Grade 3 febrile neutropenia in 1, and Grade 3 esophagitis in 1). Moreover, late Grade 3 pneumothorax and Grade 5 pneumonitis occurred in 1 and 1 patient, respectively. Overall, Grade 2, 3 and 5 pneumonitis occurred in 3, 3, and 1 among 16 patients, respectively. Conclusions: Concurrent vinorelbine and thoracic radiotherapy resulted in a high incidence of severe pneumonitis when the standard dose of this agent was used for elderly patients. We therefore recommend caution in the use of this regimen and schedule for elderly patients.

Harada, Hideyuki, E-mail: h.harada@scchr.jp [Division of Radiation Oncology, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Sunto-gun, Shizuoka (Japan); Seto, Takashi [Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka (Japan); Igawa, Satoshi [Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Sunto-gun, Shizuoka (Japan); Department of Respiratory Medicine, Kitasato University School of Medicine, Kanagawa (Japan); Tsuya, Asuka [Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Sunto-gun, Shizuoka (Japan); Wada, Mayuko [Department of Respiratory Medicine, Kitasato University School of Medicine, Kanagawa (Japan); Kaira, Kyoichi; Naito, Tateaki [Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Sunto-gun, Shizuoka (Japan); Hayakawa, Kazushige [Department of Radiology, Kitasato University School of Medicine, Kanagawa (Japan); Nishimura, Tetsuo [Division of Radiation Oncology, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Sunto-gun, Shizuoka (Japan); Masuda, Noriyuki [Department of Respiratory Medicine, Kitasato University School of Medicine, Kanagawa (Japan); Yamamoto, Nobuyuki [Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Sunto-gun, Shizuoka (Japan)

2012-04-01T23:59:59.000Z

171

Int6 Expression Can Predict Survival in Early-Stage Non–Small Cell Lung Cancer Patients  

Science Journals Connector (OSTI)

...were then purified by ethanol precipitation and resuspended in 25 to 50...may begin during the first phases of the neoplastic growth...207-17. 10 Yahalom A, Kim TH, Winter E, Karniol B, von Arnim AG...classification of tumors: histological typing of lung and pleural tumors...

Fiamma Buttitta; Carla Martella; Fabio Barassi; Lara Felicioni; Simona Salvatore; Sandra Rosini; Tommaso D'Antuono; Antonio Chella; Felice Mucilli; Rocco Sacco; Andrea Mezzetti; Franco Cuccurullo; Robert Callahan; and Antonio Marchetti

2005-05-01T23:59:59.000Z

172

A Phase I Study of Chemoradiotherapy With Use of Involved-Field Conformal Radiotherapy and Accelerated Hyperfractionation for Stage III Non-Small Cell Lung Cancer: WJTOG 3305  

SciTech Connect (OSTI)

Purpose: A Phase I study to determine a recommended dose of thoracic radiotherapy using accelerated hyperfractionation for unresectable non-small-cell lung cancer was conducted. Methods and Materials: Patients with unresectable Stage III non-small-cell lung cancer were treated intravenously with carboplatin (area under the concentration curve 2) and paclitaxel (40 mg/m{sup 2}) on Days 1, 8, 15, and 22 with concurrent twice-daily thoracic radiotherapy (1.5 Gy per fraction) beginning on Day 1 followed by two cycles of consolidation chemotherapy using carboplatin (area under the concentration curve 5) and paclitaxel (200 mg/m{sup 2}). Total doses were 54 Gy in 36 fractions, 60 Gy in 40 fractions, 66 Gy in 44 fractions, and 72 Gy in 48 fractions at Levels 1 to 4. The dose-limiting toxicity, defined as Grade {>=}4 esophagitis and neutropenic fever and Grade {>=}3 other nonhematologic toxicities, was monitored for 90 days. Results: Of 26 patients enrolled, 22 patients were assessable for response and toxicity. When 4 patients entered Level 4, enrollment was closed to avoid severe late toxicities. Dose-limiting toxicities occurred in 3 patients. They were Grade 3 neuropathy at Level 1 and Level 3 and Grade 3 infection at Level 1. However, the maximum tolerated dose was not reached. The median survival time was 28.6 months for all patients. Conclusions: The maximum tolerated dose was not reached, although the dose of radiation was escalated to 72 Gy in 48 fractions. However, a dose of 66 Gy in 44 fractions was adopted for this study because late toxicity data were insufficient.

Tada, Takuhito, E-mail: tada@msic.med.osaka-cu.ac.jp [Department of Radiology, Osaka City University Graduate School of Medicine, Osaka (Japan); Department of Radiology, Izumi Municipal Hospital, Izumi (Japan); Chiba, Yasutaka [Department of Environmental Medicine and Behavioural Science, Kinki University Faculty of Medicine, Osaka-sayama (Japan); Tsujino, Kayoko [Department of Radiation Oncology, Hyogo Cancer Center, Akashi (Japan); Fukuda, Haruyuki [Department of Radiology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino (Japan); Nishimura, Yasumasa [Department of Radiation Oncology, Kinki University Faculty of Medicine, Osaka-sayama (Japan); Kokubo, Masaki [Division of Radiation Oncology, Institute of Biomedical Research and Innovation, Kobe (Japan); Negoro, Shunichi [Department of Medical Oncology, Hyogo Cancer Center, Akashi (Japan); Kudoh, Shinzoh [Department of Respiratory Medicine, Osaka City University Graduate School of Medicine, Osaka (Japan); Fukuoka, Masahiro [Department of Medical Oncology, Izumi Municipal Hospital, Izumi (Japan); Nakagawa, Kazuhiko [Department of Medical Oncology, Kinki University Faculty of Medicine, Osaka-sayama (Japan); Nakanishi, Yoichi [Research Institute for Disease of the Chest, Graduate School of Medical Science, Kyusyu University, Fukuoka (Japan)

2012-05-01T23:59:59.000Z

173

Disturbance of DKK1 level is partly involved in survival of lung cancer cells via regulation of ROMO1 and ?-radiation sensitivity  

SciTech Connect (OSTI)

Highlights: •DKK1 was expressed differently among non-small-cell lung cancer cell lines. •DKK1 negatively regulated ROMO1 gene expression. •Disturbance of DKK1 level induced the imbalance of cellular ROS. •DKK1/ROMO1-induced ROS imbalance is involved in cell survival in NSCLC. -- Abstract: Dickkopf1 (DKK1), a secreted protein involved in embryonic development, is a potent inhibitor of the Wnt signaling pathway and has been postulated to be a tumor suppressor or tumor promoter depending on the tumor type. In this study, we showed that DKK1 was expressed differently among non-small-cell lung cancer cell lines. The DKK1 expression level was much higher in A549 cells than in H460 cells. We revealed that blockage of DKK1 expression by silencing RNA in A549 cells caused up-regulation of intracellular reactive oxygen species (ROS) modulator (ROMO1) protein, followed by partial cell death, cell growth inhibition, and loss of epithelial–mesenchymal transition property caused by ROS, and it also increased ?-radiation sensitivity. DKK1 overexpression in H460 significantly inhibited cell survival with the decrease of ROMO1 level, which induced the decrease of cellular ROS. Thereafter, exogenous N-acetylcysteine, an antioxidant, or hydrogen peroxide, a pro-oxidant, partially rescued cells from death and growth inhibition. In each cell line, both overexpression and blockage of DKK1 not only elevated p-RB activation, which led to cell growth arrest, but also inactivated AKT/NF-kB, which increased radiation sensitivity and inhibited cell growth. This study is the first to demonstrate that strict modulation of DKK1 expression in different cell types partially maintains cell survival via tight regulation of the ROS-producing ROMO1 and radiation resistance.

Kim, In Gyu, E-mail: igkim@kaeri.re.kr [Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600 (Korea, Republic of); Department of Radiation Biotechnology and Applied Radioisotope, University of Science and Technology (UST), 989-111 Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Kim, Seo Yoen [Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600 (Korea, Republic of) [Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600 (Korea, Republic of); Biomedical Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Korea, Republic of); Kim, Hyun A; Kim, Jeong Yul [Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600 (Korea, Republic of)] [Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600 (Korea, Republic of); Lee, Jae Ha; Choi, Soo Im [Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600 (Korea, Republic of) [Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600 (Korea, Republic of); Department of Radiation Biotechnology and Applied Radioisotope, University of Science and Technology (UST), 989-111 Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Han, Jeong Ran; Kim, Kug Chan [Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600 (Korea, Republic of)] [Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600 (Korea, Republic of); Cho, Eun Wie [Biomedical Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Korea, Republic of)] [Biomedical Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Korea, Republic of)

2014-01-03T23:59:59.000Z

174

Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer  

SciTech Connect (OSTI)

Highlights: •Dnmt3A and Dnmt3B are involved in the down-regulation of WIF-1 expression in non-small-cell lung cancer. •MiR-29 family members could restore WIF-1 expression through demethylation. •MiR-29s suppress Wnt/?-catenin signaling pathway and inhibit tumor growth. •The expression of miR-29a and miR-29b could be regulated partially in a positive feedback loop. -- Abstract: Wnt inhibitory factor-1 (WIF-1) silencing induced by promoter hypermethylation is a common mechanism of aberrant activation of the Wnt signaling pathway in non-small-cell lung cancer (NSCLC). However, the activity of regulators associated with the methylation of the WIF-1 gene remains unclear. Here, we investigated the role of three DNA methyltransferases (DNMT1, DNMT3A and DNMT3B) in the expression of WIF-1. The three DNMTs were up-regulated in NSCLC tumor tissues and suppression of DNMT3A and DNMT3B restored the expression of WIF-1 in NSCLC cells. The miR-29 family (miR-29a, -29b, and -29c), which negatively regulates DNMT3A and DNMT3B, was examined in association with the Wnt/?-catenin signaling pathway. A positive correlation between the expression of WIF-1 and that of MiR-29s was observed in NSCLC tissues. Methylation-specific PCR and Western blotting indicated that miR-29s positively regulate WIF-1 expression by inhibiting the methylation of its promoter. Furthermore, miR-29 overexpression downregulated ?-catenin expression, inhibited cell proliferation and induced apoptosis. The expression of miR-29a and miR-29b was partially regulated by DNMT3A and DNMT3B in a positive feedback loop. Taken together, our findings show that miR-29s suppress the Wnt signaling pathway through demethylation of WIF-1 in NSCLC.

Tan, Min [Department of Respiratory Medicine, Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072 (China)] [Department of Respiratory Medicine, Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072 (China); Wu, Junjie, E-mail: wujunjiesh@126.com [Department of Pneumology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai 200433 (China) [Department of Pneumology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai 200433 (China); State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433 (China); Cai, Yong, E-mail: dryongcai@126.com [Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433 (China)] [Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433 (China)

2013-09-06T23:59:59.000Z

175

SOX7 is downregulated and functions as a tumor suppressive transcription factor in breast cancer.  

E-Print Network [OSTI]

??Second only to lung cancer, breast cancer is the leading cause of cancer-related deaths in American women. Breast cancer is a heterogeneous set of diseases… (more)

Stovall, Daniel B.

2014-01-01T23:59:59.000Z

176

Evolutionary Modeling of Combination Treatment Strategies To Overcome Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer  

E-Print Network [OSTI]

of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, Palo Alto, California populations. Our mathematical model predicts the population dynamics of mixtures of sensitive and resistant

177

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer  

E-Print Network [OSTI]

Chemotherapy resistance is a major obstacle in cancer treatment, yet the mechanisms of response to specific therapies have been largely unexplored in vivo. Employing genetic, genomic, and imaging approaches, we examined ...

Oliver, Trudy Gale

178

Association of Energy Intake and Energy Balance with Postmenopausal Breast Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial  

Science Journals Connector (OSTI)

...extreme estimates of energy consumption (upper or lower...Implication of total energy intake for epidemiologic...equation for resting energy expenditure in...per capita food consumption. Cancer 1986...of the effect of World War II in Norway...

Shih-Chen Chang; Regina G. Ziegler; Barbara Dunn; Rachael Stolzenberg-Solomon; James V. Lacey, Jr.; Wen-Yi Huang; Arthur Schatzkin; Douglas Reding; Robert N. Hoover; Patricia Hartge; and Michael F. Leitzmann

2006-02-01T23:59:59.000Z

179

Association of Energy Intake and Energy Balance with Postmenopausal Breast Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial  

Science Journals Connector (OSTI)

...may also underreport energy intake and overreport...linked to breast cancer status, and our questionnaires...unmeasured components of energy balance, such as occupational...recreational activity, enabled us to consider all three energy balance variables concurrently...

Shih-Chen Chang; Regina G. Ziegler; Barbara Dunn; Rachael Stolzenberg-Solomon; James V. Lacey, Jr.; Wen-Yi Huang; Arthur Schatzkin; Douglas Reding; Robert N. Hoover; Patricia Hartge; and Michael F. Leitzmann

2006-02-01T23:59:59.000Z

180

Response and Resistance to NF-?B Inhibitors in Mouse Models of Lung Adenocarcinoma  

E-Print Network [OSTI]

Lung adenocarcinoma is a leading cause of cancer death worldwide. We recently showed that genetic inhibition of the NF-?B pathway affects both the initiation and the maintenance of lung cancer, identifying this pathway as ...

Xue, Wen

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Predictive Treatment Management: Incorporating a Predictive Tumor Response Model Into Robust Prospective Treatment Planning for Non-Small Cell Lung Cancer  

SciTech Connect (OSTI)

Purpose: We hypothesized that a treatment planning technique that incorporates predicted lung tumor regression into optimization, predictive treatment planning (PTP), could allow dose escalation to the residual tumor while maintaining coverage of the initial target without increasing dose to surrounding organs at risk (OARs). Methods and Materials: We created a model to estimate the geometric presence of residual tumors after radiation therapy using planning computed tomography (CT) and weekly cone beam CT scans of 5 lung cancer patients. For planning purposes, we modeled the dynamic process of tumor shrinkage by morphing the original planning target volume (PTV{sub orig}) in 3 equispaced steps to the predicted residue (PTV{sub pred}). Patients were treated with a uniform prescription dose to PTV{sub orig}. By contrast, PTP optimization started with the same prescription dose to PTV{sub orig} but linearly increased the dose at each step, until reaching the highest dose achievable to PTV{sub pred} consistent with OAR limits. This method is compared with midcourse adaptive replanning. Results: Initial parenchymal gross tumor volume (GTV) ranged from 3.6 to 186.5 cm{sup 3}. On average, the primary GTV and PTV decreased by 39% and 27%, respectively, at the end of treatment. The PTP approach gave PTV{sub orig} at least the prescription dose, and it increased the mean dose of the true residual tumor by an average of 6.0 Gy above the adaptive approach. Conclusions: PTP, incorporating a tumor regression model from the start, represents a new approach to increase tumor dose without increasing toxicities, and reduce clinical workload compared with the adaptive approach, although model verification using per-patient midcourse imaging would be prudent.

Zhang, Pengpeng, E-mail: zhangp@mskcc.org [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Yorke, Ellen; Hu, Yu-Chi; Mageras, Gig [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Rimner, Andreas [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Deasy, Joseph O. [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

2014-02-01T23:59:59.000Z

182

A Dose-Volume Analysis of Radiation Pneumonitis in Non-Small Cell Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy  

SciTech Connect (OSTI)

Purpose: To examine the rates and risk factors of radiation pneumonitis (RP) in non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT). Methods and Materials: Dosimetry records for 251 patients with lymph node-negative Stage I-IIB NSCLC and no prior chest radiation therapy (RT) treated with SBRT were reviewed. Patients were coded on the basis of the presence of at least Grade (G) 2 RP using the Common Toxicity Criteria version 2 criteria. Radiation doses, V5, V10, V20, and mean lung dose (MLD) data points were extracted from the dose-volume histogram (DVH). Results: Median PTV volume was 48 cc. Median prescribed radiation dose was 60 Gy delivered in three fractions to the 80% isodose line. Median age at treatment was 74 years. Median follow-up was 17 months. RP was reported after treatment of 42 lesions: G1 in 19 (8%), G2 in 17 (7%), G3 in 5 (2%), and G4 in 1 (0.4%). Total lung DVHs were available for 143 patients. For evaluable patients, median MLD, V5, V10, and V20 were 4.1 Gy, 20%, 12%, and 4%, respectively. Median MLDs were 4 Gy and 5 Gy for G0-1 and G2-4 groups, respectively (p = 0.14); median V5 was 20% for G0-1 and 24% for G2-4 (p = 0.70); median V10 was 12% in G0-1 and 16% in G2-4 (p = 0.08), and median V20 was 4% in G0-1 and 6.6% in G2-4 (p = 0.05). G2-4 RP was noted in 4.3% of patients with MLD {<=}4 Gy compared with 17.6% of patients with MLD >4 Gy (p = 0.02), and in 4.3% of patients with V20 {<=}4% compared with 16.4% of patients with V20 >4% (p = 0.03). Conclusion: Overall rate of G2-4 RP in our population treated with SBRT was 9.4%. Development of symptomatic RP in this series correlated with MLD and V20.

Barriger, R. Bryan [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN (United States); Forquer, Jeffrey A. [Toledo Radiation Oncology Inc., Toledo, OH (United States); Department of Radiation Oncology, University of Toledo, Toledo, OH (United States); Brabham, Jeffrey G. [Florida Hospital Cancer Institute Waterman, Tavares, Florida (United States); Andolino, David L.; Shapiro, Ronald H.; Henderson, Mark A.; Johnstone, Peter A.S. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN (United States); Fakiris, Achilles J., E-mail: afakiris@iupui.edu [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN (United States)

2012-01-01T23:59:59.000Z

183

Residential Radon Exposure, Histologic Types, and Lung Cancer Risk. A Case–Control Study in Galicia, Spain  

Science Journals Connector (OSTI)

...a federal action plan for saving lives...Radon_Action_Plan.pdf . 6. A citizen's...exposure? A systematic review.Int J Radiat Biol...and American Indian uranium miners: an update...carcinoma in German uranium miners.Cancer 2006...was measured using standard procedures. Results...

Juan Miguel Barros-Dios; Alberto Ruano-Ravina; Mónica Pérez-Ríos; Margarita Castro-Bernárdez; Jose Abal-Arca; and Marta Tojo-Castro

2012-06-01T23:59:59.000Z

184

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer  

E-Print Network [OSTI]

Abstract Background The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This can only be achieved if the drug used is against a specific target...

Toyokawa, Gouji; Masuda, Ken; Daigo, Yataro; Cho, Hyun-Soo; Yoshimatsu, Masanori; Takawa, Masashi; Hayami, Shinya; Maejima, Kazuhiro; Chino, Makoto; Field, Helen I; Neal, David E; Tsuchiya, Eiju; Ponder, Bruce A J; Maehara, Yoshihiko; Nakamura, Yusuke; Hamamoto, Ryuji

2011-05-28T23:59:59.000Z

185

Association of Energy Intake and Energy Balance with Postmenopausal Breast Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial  

Science Journals Connector (OSTI)

...risk of women with a favorable energy balance. Our findings are compatible...nonsignificant, associations between energy intake and breast cancer (22, 23). In a study from Norway (22), women in the highest quartile of energy intake had an increased breast...

Shih-Chen Chang; Regina G. Ziegler; Barbara Dunn; Rachael Stolzenberg-Solomon; James V. Lacey, Jr.; Wen-Yi Huang; Arthur Schatzkin; Douglas Reding; Robert N. Hoover; Patricia Hartge; and Michael F. Leitzmann

2006-02-01T23:59:59.000Z

186

Association of Energy Intake and Energy Balance with Postmenopausal Breast Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial  

Science Journals Connector (OSTI)

...XO, et al. Energy balance and breast...cancer in western New York. Am J Epidemiol...Implication of total energy intake for epidemiologic...Epidemiology. New York (NY): Oxford...Koh YO. A new predictive equation for resting energy expenditure in...

Shih-Chen Chang; Regina G. Ziegler; Barbara Dunn; Rachael Stolzenberg-Solomon; James V. Lacey, Jr.; Wen-Yi Huang; Arthur Schatzkin; Douglas Reding; Robert N. Hoover; Patricia Hartge; and Michael F. Leitzmann

2006-02-01T23:59:59.000Z

187

Downregulation of miR-497 promotes tumor growth and angiogenesis by targeting HDGF in non-small cell lung cancer  

SciTech Connect (OSTI)

Highlights: •MiR-497 is down-regulated in NSCLC cells and tissues. •MiR-497 inhibits NSCLC cell growth in vitro. •HDGF is a target gene of miR-497. •MiR-497 inhibits NSCLC cell growth by downregulating HDGF. •miR-497 inhibits tumor growth and angiogenesis in vivo. -- Abstract: MicroRNAs (miRNAs) play important roles in the development of various cancers. MiRNA-497 functions as a tumor-suppressor that is downregulated in several malignancies; however, its role in non-small cell lung cancer (NSCLC) has not been examined in detail. Here, we showed that miR-497 is downregulated in NSCLC tumors and cell lines and its ectopic expression significantly inhibits cell proliferation and colony formation. Integrated analysis identified HDGF as a downstream target of miR-497, and the downregulation of HDGF by miR-497 overexpression confirmed their association. Rescue experiments showed that the inhibitory effect of miR-497 on cell proliferation and colony formation is predominantly mediated by the modulation of HDGF levels. Furthermore, tumor samples from NSCLC patients showed an inverse relationship between miR-497 and HDGF levels, and ectopic expression of miR-497 significantly inhibited tumor growth and angiogenesis in a SCID mouse xenograft model. Our results suggest that miR-497 may serve as a biomarker in NSCLC, and the modulation of its activity may represent a novel therapeutic strategy for the treatment of NSCLC patients.

Zhao, Wen-yan [Department of Medical Oncology, Jiamusi Tumor Hospital, Jiamusi 154007 (China)] [Department of Medical Oncology, Jiamusi Tumor Hospital, Jiamusi 154007 (China); Wang, Yan [Department of Medical Oncology, The Third Affliated Hospital of Harbin Medical University, Harbin 150081 (China)] [Department of Medical Oncology, The Third Affliated Hospital of Harbin Medical University, Harbin 150081 (China); An, Zhong-jun; Shi, Chang-guo; Zhu, Guang-ai; Wang, Bin; Lu, Ming-yan; Pan, Chang-kun [Department of Medical Oncology, Jiamusi Tumor Hospital, Jiamusi 154007 (China)] [Department of Medical Oncology, Jiamusi Tumor Hospital, Jiamusi 154007 (China); Chen, Peng, E-mail: chenpengdoc@126.com [Lung Cancer Medicine Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060 (China)] [Lung Cancer Medicine Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060 (China)

2013-06-07T23:59:59.000Z

188

Influence of Technologic Advances on Outcomes in Patients With Unresectable, Locally Advanced Non-Small-Cell Lung Cancer Receiving Concomitant Chemoradiotherapy  

SciTech Connect (OSTI)

Purpose: In 2004, our institution began using four-dimensional computed tomography (4DCT) simulation and then intensity-modulated radiotherapy (IMRT) (4DCT/IMRT) instead of three-dimensional conformal radiotherapy (3DCRT) for the standard treatment of non-small-cell lung cancer (NSCLC). This retrospective study compares disease outcomes and toxicity in patients treated with concomitant chemotherapy and either 4DCT/IMRT or 3DCRT. Methods and Materials: A total of 496 NSCLC patients have been treated at M. D. Anderson Cancer Center between 1999 and 2006 with concomitant chemoradiotherapy. Among these, 318 were treated with CT/3DCRT and 91 with 4DCT/IMRT. Both groups received a median dose of 63 Gy. Disease end points were locoregional progression (LRP), distant metastasis (DM), and overall survival (OS). Disease covariates were gross tumor volume (GTV), nodal status, and histology. The toxicity end point was Grade >=3 radiation pneumonitis; toxicity covariates were GTV, smoking status, and dosimetric factors. Data were analyzed using Cox proportional hazards models. Results: Mean follow-up times in the 4DCT/IMRT and CT/3DCRT groups were 1.3 (range, 0.1-3.2) and 2.1 (range, 0.1-7.9) years, respectively. The hazard ratios for 4DCT/IMRT were <1 for all disease end points; the difference was significant only for OS. The toxicity rate was significantly lower in the IMRT/4DCT group than in the CT/3DCRT group. V20 was significantly higher in the 3DCRT group and was a significant factor in determining toxicity. Freedom from DM was nearly identical in both groups. Conclusions: Treatment with 4DCT/IMRT was at least as good as that with 3DCRT in terms of the rates of freedom from LRP and DM. There was a significant reduction in toxicity and a significant improvement in OS.

Liao, Zhongxing X., E-mail: zliao@mdanderson.or [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Komaki, Ritsuko R. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Thames, Howard D. [Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Liu, Helen H. [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Tucker, Susan L. [Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Mohan, Radhe; Martel, Mary K. [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Wei Xiong; Yang Kunyu [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Kim, Edward S.; Blumenschein, George; Hong, Waun Ki [Department of Head and Neck/Thoracic Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Cox, James D. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

2010-03-01T23:59:59.000Z

189

Radon impact in patients with broncho-pulmonary cancer in centre areas of Transylvania  

Science Journals Connector (OSTI)

Lung cancer is the most frequent cause of mortality caused by malignancies in the world. Radon, the second recognized carcinogenic agent involved in the development of lung cancer, after smoking, is a noble gas with a high mobility. By being continuously ... Keywords: lung cancer, morpho-pathological type of the lung cancer, prevention, radon, smoking, smoking cessation

Doina Adina Todea; Constantin Cosma; Loredana Elena Rosca; Andreea Cristina Herescu; Tiberius Dicu; Natalia Neagoe

2009-09-01T23:59:59.000Z

190

Using Generalized Equivalent Uniform Dose Atlases to Combine and Analyze Prospective Dosimetric and Radiation Pneumonitis Data From 2 Non-Small Cell Lung Cancer Dose Escalation Protocols  

SciTech Connect (OSTI)

Purpose: To demonstrate the use of generalized equivalent uniform dose (gEUD) atlas for data pooling in radiation pneumonitis (RP) modeling, to determine the dependence of RP on gEUD, to study the consistency between data sets, and to verify the increased statistical power of the combination. Methods and Materials: Patients enrolled in prospective phase I/II dose escalation studies of radiation therapy of non-small cell lung cancer at Memorial Sloan-Kettering Cancer Center (MSKCC) (78 pts) and the Netherlands Cancer Institute (NKI) (86 pts) were included; 10 (13%) and 14 (17%) experienced RP requiring steroids (RPS) within 6 months after treatment. gEUD was calculated from dose-volume histograms. Atlases for each data set were created using 1-Gy steps from exact gEUDs and RPS data. The Lyman-Kutcher-Burman model was fit to the atlas and exact gEUD data. Heterogeneity and inconsistency statistics for the fitted parameters were computed. gEUD maps of the probability of RPS rate {>=}20% were plotted. Results: The 2 data sets were homogeneous and consistent. The best fit values of the volume effect parameter a were small, with upper 95% confidence limit around 1.0 in the joint data. The likelihood profiles around the best fit a values were flat in all cases, making determination of the best fit a weak. All confidence intervals (CIs) were narrower in the joint than in the individual data sets. The minimum P value for correlations of gEUD with RPS in the joint data was .002, compared with P=.01 and .05 for MSKCC and NKI data sets, respectively. gEUD maps showed that at small a, RPS risk increases with gEUD. Conclusions: The atlas can be used to combine gEUD and RPS information from different institutions and model gEUD dependence of RPS. RPS has a large volume effect with the mean dose model barely included in the 95% CI. Data pooling increased statistical power.

Liu Fan; Yorke, Ellen D. [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Belderbos, Jose S.A.; Borst, Gerben R. [The Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [The Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Amsterdam (Netherlands); Rosenzweig, Kenneth E. [Mount Sinai School of Medicine, New York, New York (United States)] [Mount Sinai School of Medicine, New York, New York (United States); Lebesque, Joos V. [The Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [The Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Amsterdam (Netherlands); Jackson, Andrew, E-mail: jacksona@mskcc.org [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

2013-01-01T23:59:59.000Z

191

Cost-Effectiveness of CT Screening in the National Lung Screening Trial  

Science Journals Connector (OSTI)

Lung cancer is the leading cause of cancer-related deaths in the United States; however, until recently, no method of screening had been shown to reduce mortality from lung cancer. The National Lung Screening Trial (NLST) showed that screening with low-dose helical computed tomography (CT) of the... The screening of persons at risk for lung cancer may reduce lung-cancer mortality by 20%. Although cost-effectiveness estimates vary widely depending on assumptions, a careful analysis indicates that the cost is $81,000 per quality-adjusted life-year.

Black W.C.; Gareen I.F.; Soneji S.S.

2014-11-06T23:59:59.000Z

192

Long-term Changes in Pulmonary Function After Incidental Lung Irradiation for Breast Cancer: A Prospective Study With 7-Year Follow-up  

SciTech Connect (OSTI)

Purpose: To evaluate late pulmonary function changes after incidental pulmonary irradiation for breast cancer. Methods and Materials: Forty-three consecutive female patients diagnosed with breast carcinoma and treated with postoperative radiation therapy (RT) at the same dose (50 Gy) and fractionation (2 Gy/fraction, 5 days/week) were enrolled. Pulmonary function tests (PFT) and ventilation/perfusion scans were performed before RT and 6, 12, 24, and 84 months afterward. Results: Forty-one patients, mean age 55 years, were eligible for the analysis. No differences were found in the baseline PFT values for age, smoking status and previous chemotherapy; women undergoing mastectomy showed baseline spirometric PFT values lower than did women treated with conservative surgery. The mean pulmonary dose was 10.9 Gy, being higher in women who also received lymph node RT (15.8 vs 8.6, P<.01). Only 1 patient experienced symptomatic pneumonitis. All PFT values showed a reduction at 6 months. From then on, the forced vital capacity and forced expiratory volume in 1 second began their recovery until reaching, and even exceeding, their baseline values at 7 years. Diffusing capacity of the lungs for carbon monoxide and ventilation/perfusion scans continued to reduce for 24 months and then partially recovered their baseline values (-3.5%, -3.8%, and -5.5%, respectively). Only the percentage difference at 7 years in the ventilation scan correlated with the dosimetric parameters studied. Other variables, such as age, smoking status, previous chemotherapy, and concomitant tamoxifen showed no significant relation with changes in PFT ({Delta}PFT) values at 7 years. Conclusions: The study of reproducible subclinical parameters, such as PFT values, shows how their figures decrease in the first 2 years but practically recover their baseline values in the long term. The extent of the reduction in PFT values was small, and there was no clear association with several dosimetric and clinical parameters.

Jaen, Javier, E-mail: javier.jaen.sspa@juntadeandalucia.es [Unidad de Atencion Integral al Cancer, Hospital Universitario Puerta del Mar, Cadiz (Spain)] [Unidad de Atencion Integral al Cancer, Hospital Universitario Puerta del Mar, Cadiz (Spain); Vazquez, Gonzalo [Servicio de Oncologia Radioterapica, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid (Spain)] [Servicio de Oncologia Radioterapica, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid (Spain); Alonso, Enrique; De Las Penas, Maria D.; Diaz, Laura [Unidad de Atencion Integral al Cancer, Hospital Universitario Puerta del Mar, Cadiz (Spain)] [Unidad de Atencion Integral al Cancer, Hospital Universitario Puerta del Mar, Cadiz (Spain); De Las Heras, Manuel [Servicio de Oncologia Radioterapica, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid (Spain)] [Servicio de Oncologia Radioterapica, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid (Spain); Perez-Regadera, Jose F. [Servicio de Oncologia Radioterapica, Hospital Universitario Doce de Octubre, Madrid (Spain)] [Servicio de Oncologia Radioterapica, Hospital Universitario Doce de Octubre, Madrid (Spain)

2012-12-01T23:59:59.000Z

193

Assessment of Gross Tumor Volume Regression and Motion Changes During Radiotherapy for Non-Small-Cell Lung Cancer as Measured by Four-Dimensional Computed Tomography  

SciTech Connect (OSTI)

Purpose: To investigate the magnitudes of the changes in mobility and volume of locally advanced non-small-cell lung cancer (NSCLC) tumors during radiotherapy, using four-dimensional computed tomography (4DCT). Methods and Materials: Five to ten 4DCT data sets were acquired weekly for each of 8 patients throughout treatment. Gross tumor volumes (GTVs) were outlined on each data set. Volumes and coordinates of the GTV centroids were calculated at the 0 (end-inspiration) and 50% (end-expiration) respiration phases. Trends in magnitudes of intrafraction and interfraction positional variations were assessed for the GTV and internal target volume (ITV) during treatment. Results: Tumor volume reduction ranged from 20% to 71% (end-inspiration) and from 15% to 70% (end-expiration). Increased tumor mobility was observed in the superior-inferior and anterior-posterior directions. However, no trends in tumor motion were observed. Motion along the superior-inferior direction was significantly greater (p < 0.001), with mean {+-} SD values of 0.86 {+-} 0.19 cm, as compared with 0.39 {+-} 0.08 cm and 0.19 {+-} 0.05 cm in the anterior-posterior and right-left directions, respectively. A marginally significant (p = 0.049) increase in total GTV positional variation was observed with increasing treatment weeks, and similar results were seen for the interfractional ITV mobility. Conclusions: Because of changes in tumor size and mobility, an explicit initial determination of the ITV may not be sufficient, especially where small setup margins are used. Repeat 4DCT scans might be warranted for highly mobile tumors to reduce the potential for missing the tumor.

Britton, Keith R. [Radiation Oncology Division, Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston TX (United States)]. E-mail: kbritton@mdanderson.org; Starkschall, George [Radiation Oncology Division, Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston TX (United States); Tucker, Susan L. [Department of Biostatistics and Applied Mathematics, University of Texas M. D. Anderson Cancer Center, Houston TX (United States); Pan Tinsu [Department of Imaging Physics, University of Texas M. D. Anderson Cancer Center, Houston TX (United States); Nelson, Christopher [Radiation Oncology Division, Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston TX (United States); Chang, Joe Y. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston TX (United States); Cox, James D. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston TX (United States); Mohan, Radhe [Radiation Oncology Division, Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston TX (United States); Komaki, Ritsuko [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston TX (United States)

2007-07-15T23:59:59.000Z

194

Failure of ozone and nitrogen dioxide to enhance lung tumor development in hamsters  

SciTech Connect (OSTI)

We tested the hypothesis that the two common oxidant air pollutants, ozone and nitrogen dioxide, modulate the development of respiratory tract tumors in Syrian golden hamsters. The animals received subcutaneous injections of the carcinogen diethylnitrosamine (20 mg/kg) twice a week while being exposed continuously to an atmosphere of 0.8 parts per million (ppm)* of ozone or 15 ppm of nitrogen dioxide. Animals were killed 16 weeks or 24 to 32 weeks after the beginning of the treatment. Ozone delayed the appearance of tracheal tumors and reduced the incidence of tumors in the lung periphery. A suspected neuroendocrine differentiation of those lung tumors could not be established by immunocytochemistry due to overfixation of tissues. On the other hand, ozone seemed to mitigate development of hepatotoxic lesions mediated by diethylnitrosamine. In animals treated with diethylnitrosamine and exposed to nitrogen dioxide, fewer tracheal tumors and no lung tumors were found. Only a few lung tumors were produced in animals treated with diethylnitrosamine and kept in an atmosphere of 65% oxygen. The previously observed neuroendocrine nature of tumors induced by simultaneous exposure to diethylnitrosamine and hyperoxia could not be established because the long fixation of tissues precluded immunocytochemical stains. Animals treated with diethylnitrosamine and kept in filtered air while being housed in wire-mesh cages developed fewer lung tumors than animals given the same treatment and kept on conventional bedding in shoebox cages. Although all inhalants tested are known to produce substantial cell proliferation in the respiratory tract, it was not possible to document whether this would enhance lung tumor development. The role of the two common air pollutants, ozone and nitrogen dioxide, as possible additional risks in the pathogenesis of lung cancer in animals continues to remain uncertain.

Witschi, H.; Breider, M.A.; Schuller, H.M. (Univ. of California, Davis, CA (United States))

1993-09-01T23:59:59.000Z

195

Incidents of Security Concern  

SciTech Connect (OSTI)

This presentation addresses incidents of security concern and an incident program for addressing them. It addresses the phases of an inquiry, and it divides incidents into categories based on severity and interest types based on whether security, management, or procedural interests are involved. A few scenarios are then analyzed according to these breakdowns.

Atencio, Julian J.

2014-05-01T23:59:59.000Z

196

From Mice and Men to Earth and Space: Joint NASA–NCI Workshop on Lung Cancer Risk Resulting from Space and Terrestrial Radiation  

Science Journals Connector (OSTI)

...data were limited, a radiation effect was still not...the atomic bombs in Japan (1) and among British...multiple fractionated radiation exposures to the lung...5-88). Hiroshima. Japan: Radiation Effects Re search Foundation...

Jerry W. Shay; Francis A. Cucinotta; Frank M. Sulzman; C. Norman Coleman; and John D. Minna

2011-11-15T23:59:59.000Z

197

Different Energy Metabolism in Two Human Small Cell Lung Cancer Subpopulations Examined by 31P Magnetic Resonance Spectroscopy and Biochemical Analysis in Vivo and in Vitro  

Science Journals Connector (OSTI)

...Verlag Chemie, 1974. energy phosphate content and...spectroscopy studies of tumor energy metabolism...z , z ,, and Us relationship to intracapillarv...oxvhemoelobm saturation status and Ed. 2. New York...1989. Levels of high energy phosphates in human lung...

Paul E. G. Kristjansen; Mogens Spang-Thomsen; and Bjørn Quistorff

1991-10-01T23:59:59.000Z

198

Modeling the Risk of Radiation-Induced Acute Esophagitis for Combined Washington University and RTOG Trial 93-11 Lung Cancer Patients  

SciTech Connect (OSTI)

Purpose: To construct a maximally predictive model of the risk of severe acute esophagitis (AE) for patients who receive definitive radiation therapy (RT) for non-small-cell lung cancer. Methods and Materials: The dataset includes Washington University and RTOG 93-11 clinical trial data (events/patients: 120/374, WUSTL = 101/237, RTOG9311 = 19/137). Statistical model building was performed based on dosimetric and clinical parameters (patient age, sex, weight loss, pretreatment chemotherapy, concurrent chemotherapy, fraction size). A wide range of dose-volume parameters were extracted from dearchived treatment plans, including Dx, Vx, MOHx (mean of hottest x% volume), MOCx (mean of coldest x% volume), and gEUD (generalized equivalent uniform dose) values. Results: The most significant single parameters for predicting acute esophagitis (RTOG Grade 2 or greater) were MOH85, mean esophagus dose (MED), and V30. A superior-inferior weighted dose-center position was derived but not found to be significant. Fraction size was found to be significant on univariate logistic analysis (Spearman R = 0.421, p < 0.00001) but not multivariate logistic modeling. Cross-validation model building was used to determine that an optimal model size needed only two parameters (MOH85 and concurrent chemotherapy, robustly selected on bootstrap model-rebuilding). Mean esophagus dose (MED) is preferred instead of MOH85, as it gives nearly the same statistical performance and is easier to compute. AE risk is given as a logistic function of (0.0688 Asterisk-Operator MED+1.50 Asterisk-Operator ConChemo-3.13), where MED is in Gy and ConChemo is either 1 (yes) if concurrent chemotherapy was given, or 0 (no). This model correlates to the observed risk of AE with a Spearman coefficient of 0.629 (p < 0.000001). Conclusions: Multivariate statistical model building with cross-validation suggests that a two-variable logistic model based on mean dose and the use of concurrent chemotherapy robustly predicts acute esophagitis risk in combined-data WUSTL and RTOG 93-11 trial datasets.

Huang, Ellen X.; Bradley, Jeffrey D.; El Naqa, Issam [Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO (United States); Hope, Andrew J.; Lindsay, Patricia E. [Princess Margaret Hospital, Toronto, ON (Canada); Bosch, Walter R.; Matthews, John W. [Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO (United States); Sause, William T. [Department of Radiation Oncology, LDS Hospital, Salt Lake City, UT (United States); Graham, Mary V. [Department of Radiation Oncology, Phelps County Regional Hospital, Rolla, MO (United States); Deasy, Joseph O., E-mail: deasyj@mskcc.org [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

2012-04-01T23:59:59.000Z

199

The Impact of Extent and Location of Mediastinal Lymph Node Involvement on Survival in Stage III Non-Small Cell Lung Cancer Patients Treated With Definitive Radiotherapy  

SciTech Connect (OSTI)

Purpose: Several surgical series have identified subcarinal, contralateral, and multilevel nodal involvement as predictors of poor overall survival in patients with Stage III non-small-cell lung cancer (NSCLC) treated with definitive resection. This retrospective study evaluates the impact of extent and location of mediastinal lymph node (LN) involvement on survival in patients with Stage III NSCLC treated with definitive radiotherapy. Methods and Materials: We analyzed 106 consecutive patients with T1-4 N2-3 Stage III NSCLC treated with definitive radiotherapy at University of Pennsylvania between January 2003 and February 2009. For this analysis, mediastinal LN stations were divided into four mutually exclusive groups: supraclavicular, ipsilateral mediastinum, contralateral mediastinum, and subcarinal. Patients' conditions were then analyzed according to the extent of involvement and location of mediastinal LN stations. Results: The majority (88%) of patients received sequential or concurrent chemotherapy. The median follow-up time for survivors was 32.6 months. By multivariable Cox modeling, chemotherapy use (hazard ratio [HR]: 0.21 [95% confidence interval (CI): 0.07-0.63]) was associated with improved overall survival. Increasing primary tumor [18F]-fluoro-2-deoxy-glucose avidity (HR: 1.11 [CI: 1.06-1.19]), and subcarinal involvement (HR: 2.29 [CI: 1.11-4.73]) were significant negative predictors of overall survival. On univariate analysis, contralateral nodal involvement (HR: 0.70 [CI: 0.33-1.47]), supraclavicular nodal involvement (HR: 0.78 [CI: 0.38-1.67]), multilevel nodal involvement (HR: 0.97 [CI: 0.58-1.61]), and tumor size (HR: 1.04 [CI: 0.94-1.14]) did not predict for overall survival. Patients with subcarinal involvement also had lower rates of 2-year nodal control (51.2% vs. 74.9%, p = 0.047) and 2-year distant control (28.4% vs. 61.2%, p = 0.043). Conclusions: These data suggest that the factors that determine oncologic outcome in Stage III NSCLC patients treated with definitive radiotherapy are distinct from those observed in patients who undergo surgical resection. The ultimate efficacy of radiation in locally advanced NSCLC is dependent on the intrinsic biology of the tumor.

Fernandes, Annemarie T. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Mitra, Nandita [Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA (United States); Xanthopoulos, Eric [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Evans, Tracey; Stevenson, James; Langer, Corey [Department of Medical Oncology, University of Pennsylvania, Philadelphia, PA (United States); Kucharczuk, John C. [Department of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA (United States); Lin, Lilie; Rengan, Ramesh [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)

2012-05-01T23:59:59.000Z

200

Activation of protein kinase B (PKB/Akt) and risk of lung cancer among rural women in India who cook with biomass fuel  

SciTech Connect (OSTI)

The impact of indoor air pollution (IAP) from biomass fuel burning on the risk of carcinogenesis in the airways has been investigated in 187 pre-menopausal women (median age 34 years) from eastern India who cooked exclusively with biomass and 155 age-matched control women from same locality who cooked with cleaner fuel liquefied petroleum gas. Compared with control, Papanicolau-stained sputum samples showed 3-times higher prevalence of metaplasia and 7-times higher prevalence of dysplasia in airway epithelial cell (AEC) of biomass users. Immunocytochemistry showed up-regulation of phosphorylated Akt (p-Akt{sup ser473} and p-Akt{sup thr308}) proteins in AEC of biomass users, especially in metaplastic and dysplastic cells. Compared with LPG users, biomass-using women showed marked rise in reactive oxygen species (ROS) generation and depletion of antioxidant enzyme, superoxide dismutase (SOD) indicating oxidative stress. There were 2–5 times more particulate pollutants (PM{sub 10} and PM{sub 2.5}), 72% more nitrogen dioxide and 4-times more particulate-laden benzo(a)pyrene, but no change in sulfur dioxide in indoor air of biomass-using households, and high performance liquid chromatography estimated 6-fold rise in the concentration of benzene metabolite trans,trans-muconic acid (t,t-MA) in urine of biomass users. Metaplasia and dysplasia, p-Akt expression and ROS generation were positively associated with PM and t,t-MA levels. It appears that cumulative exposure to biomass smoke increases the risk of lung carcinogenesis via oxidative stress-mediated activation of Akt signal transduction pathway. -- Highlights: ? Carcinogenesis in airway cells was examined in biomass and LPG using women. ? Metaplasia and dysplasia of epithelial cells were more prevalent in biomass users. ? Change in airway cytology was associated with oxidative stress and Akt activation. ? Biomass users had greater exposure to respirable PM, B(a)P and benzene. ? Cooking with biomass increases cancer risk in the airways via Akt activation.

Roychoudhury, Sanghita; Mondal, Nandan Kumar; Mukherjee, Sayali; Dutta, Anindita; Siddique, Shabana; Ray, Manas Ranjan, E-mail: manasrray@rediffmail.com

2012-02-15T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Abstract A22: Clinical implication of microscopic anthracotic pigment in mediastinal staging of non-small cell lung cancer by endobronchial ultrasound-guided transbronchial needle aspiration  

Science Journals Connector (OSTI)

...Articles Randomized Trial of a Lay Health Advisor and Computer Intervention...women at two Atlanta neighborhood health centers: the implications for a cancer screening program...beliefs about breast cancer. Am J Health Promot. In press 2010. 11 Fowler...

Young Whan Kim; Young Sik Park; Jinwoo Lee; Sang-Min Lee; Jae-Joon Yim; Sung Koo Han; Jin Chul Pang; Doo Hyun Chung; and Seok-Chul Yang

2012-02-01T23:59:59.000Z

202

Information Incident Response Procedure  

E-Print Network [OSTI]

Information Incident Response Procedure Authority The Information Incident Response Procedure (IIRP) is authorized under the UWM Information Security Policy S59; section III-D (http://www4.uwm Information Security Office, and UWM Internal Audit. This document will be reviewed and updated annually

Saldin, Dilano

203

Single-Molecule Detection of Epidermal Growth Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non–Small Cell Lung Cancer Patients  

Science Journals Connector (OSTI)

...Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non-Small Cell Lung...DNA samples were analyzed using a microfluidics system that simultaneously performed...mutations in tumor tissues and plasma by microfluidics digital PCR would be useful for predicting...

Tony K.F. Yung; K.C. Allen Chan; Tony S.K. Mok; Joanna Tong; Ka-Fai To; Y.M. Dennis Lo

2009-03-15T23:59:59.000Z

204

KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer  

Science Journals Connector (OSTI)

...Immunohistochemistry-based Diagnostic System for ALK-positive Lung...Foundation of Japan; and the Vehicle Racing Commemorative...Immunohistochemical detection of EML4-ALK has proved...transcription- and PCR-based detection system for EML4-ALK (8...

Kengo Takeuchi; Young Lim Choi; Yuki Togashi; Manabu Soda; Satoko Hatano; Kentaro Inamura; Shuji Takada; Toshihide Ueno; Yoshihiro Yamashita; Yukitoshi Satoh; Sakae Okumura; Ken Nakagawa; Yuichi Ishikawa; and Hiroyuki Mano

2009-05-01T23:59:59.000Z

205

The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer  

Science Journals Connector (OSTI)

Cancer patients routinely develop symptoms consistent with profound circadian disruption, which causes circadian disruption diminished quality of life. This study was initiated to determine the relationship be...

James F Grutsch; Carol Ferrans; Patricia A Wood; Jovelyn Du-Quiton…

2011-05-01T23:59:59.000Z

206

E-Print Network 3.0 - aromatic hydrocarbon-exposed lung Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in non-smoking and smoking lung cancer... of the fetus. These mutageniccarcinogenic pollutants include aromatic compounds such as polycyclic aromatic... of transplacental exposure...

207

Trends in Area-Socioeconomic and Race-Ethnic Disparities in Breast Cancer Incidence, Stage at Diagnosis, Screening, Mortality, and Survival among Women Ages 50 Years and Over (1987-2005)  

Science Journals Connector (OSTI)

...cancer-related objectives. NCI Cancer Surveillance Monograph Series no. 7. Washington (DC): National Cancer Institute; 2007. 26 Kakwani N, Wagstaff A, van Doorslaer E. Socioeconomic inequalities in health: measurement, computation, and statistical inference...

Sam Harper; John Lynch; Stephen C. Meersman; Nancy Breen; William W. Davis; Marsha C. Reichman

2009-01-01T23:59:59.000Z

208

Abstract 5479: Somatic driver mutations among never smoking female lung cancer cases in China identify unique mutation pattern that may be associated with household coal burning  

Science Journals Connector (OSTI)

...A114: No increased risk of cancer after coal tar treatment in patients with psoriasis...2008; Washington, DC A114 Background Coal tar is an effective topical treatment for...increased risk of cancer after exposure to coal tar. Many dermatologists have abandoned...

Howard D. Hosgood; William Pao; Nathaniel Rothman; Hu Wei; Christopher Kim; Helen Pan; Kyle Kuchinsky; Kirk Jones; Jun Xu; Roel Vermeulen; Jeffery Simko; Qing Lan

2012-06-04T23:59:59.000Z

209

Incidents of Security Concern  

Broader source: Energy.gov (indexed) [DOE]

NOT MEASUREMENT NOT MEASUREMENT SENSITIVE DOE-STD-1210-2012 September 2012 DOE STANDARD Incidents of Security Concern U.S. Department of Energy AREA SANS Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. DOE-STD-1210-2012 INTENTIONALLY BLANK DOE-STD-1210-2012 TABLE OF CONTENTS PARAGRAPH PAGE FOREWORD ................................................................................................................................ IV INCIDENTS OF SECURITY CONCERN......................................................................................1 1. SCOPE ....................................................................................................................................1 2. PURPOSE...............................................................................................................................1

210

Incidents of Security Concern  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

Sets forth requirements for the DOE Incidents of Security Concern Program, including timely identification and notification of, response to, inquiry into, reporting of, and closure actions for incidents of security concern. Cancels Chapter VII of DOE O 470.1; DOE N 471.3; and Chapter IV of DOE M 471.2-1B (Note: Paragraphs 1 and 2 of Chapter III remain in effect.) Canceled by DOE O 470.4.

2004-03-17T23:59:59.000Z

211

Raw Garlic Consumption as a Protective Factor for Lung Cancer, a Population-Based Case–Control Study in a Chinese Population  

Science Journals Connector (OSTI)

...air pollution, coal-related pollution...cancer, a meta-analysis based on limited...in the present analysis to increase statistical power. From 2003 to...demographic and social economic status, weekly...Statistical analysis Data were entered...

Zi-Yi Jin; Ming Wu; Ren-Qiang Han; Xiao-Feng Zhang; Xu-Shan Wang; Ai-Ming Liu; Jin-Yi Zhou; Qing-Yi Lu; Zuo-Feng Zhang; and Jin-Kou Zhao

2013-07-01T23:59:59.000Z

212

Cancer Patterns in the Oil Shale Area of the Estonian S.S.R.  

E-Print Network [OSTI]

the Kohtla-Jarve district (oil shale area) there was an excess of stomach and lung cancer. High rates

Maret Purde; Mati Rahu

213

Childhood Cancer Tracking Initiative in Massachusetts  

E-Print Network [OSTI]

Childhood Cancer Tracking Initiative in Massachusetts: Developing a New Electronic Tool Presented (CEH) Massachusetts Department of Public Health (MDPH) #12;Childhood Cancer Tracking Initiative "Develop methods for linking environmental databases with childhood cancer incidence data to identify

214

Abstract 2043: Modeling the differential responses of cancer stem cells (CSCs) as heterogeneous versus homogenous populations in human cancers  

Science Journals Connector (OSTI)

...Biomodels, LLC, Watertown, MA. Emerging data suggests that many human cancers including breast, brain, lung, colon, pancreatic and head and neck cancer are maintained by a subpopulation of self-renewing cells characterized as cancer stem...

Maria L. Mancini

2014-10-01T23:59:59.000Z

215

Multi-walled carbon nanotube-induced gene expression in the mouse lung: Association with lung pathology  

SciTech Connect (OSTI)

Due to the fibrous shape and durability of multi-walled carbon nanotubes (MWCNT), concerns regarding their potential for producing environmental and human health risks, including carcinogenesis, have been raised. This study sought to investigate how previously identified lung cancer prognostic biomarkers and the related cancer signaling pathways are affected in the mouse lung following pharyngeal aspiration of well-dispersed MWCNT. A total of 63 identified lung cancer prognostic biomarker genes and major signaling biomarker genes were analyzed in mouse lungs (n = 80) exposed to 0, 10, 20, 40, or 80 {mu}g of MWCNT by pharyngeal aspiration at 7 and 56 days post-exposure using quantitative PCR assays. At 7 and 56 days post-exposure, a set of 7 genes and a set of 11 genes, respectively, showed differential expression in the lungs of mice exposed to MWCNT vs. the control group. Additionally, these significant genes could separate the control group from the treated group over the time series in a hierarchical gene clustering analysis. Furthermore, 4 genes from these two sets of significant genes, coiled-coil domain containing-99 (Ccdc99), muscle segment homeobox gene-2 (Msx2), nitric oxide synthase-2 (Nos2), and wingless-type inhibitory factor-1 (Wif1), showed significant mRNA expression perturbations at both time points. It was also found that the expression changes of these 4 overlapping genes at 7 days post-exposure were attenuated at 56 days post-exposure. Ingenuity Pathway Analysis (IPA) found that several carcinogenic-related signaling pathways and carcinogenesis itself were associated with both the 7 and 11 gene signatures. Taken together, this study identifies that MWCNT exposure affects a subset of lung cancer biomarkers in mouse lungs. - Research Highlights: > Multi-Walled Carbon Nanotubes affect lung cancer biomarkers in mouse lungs. > The results suggest potentially harmful effects of MWCNT exposure on human lungs. > The results could potentially be used for the medical surveillance of workers.

Pacurari, M. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Qian, Y., E-mail: yaq2@cdc.gov [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Porter, D.W.; Wolfarth, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Wan, Y.; Luo, D. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Ding, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Castranova, V. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Guo, N.L., E-mail: lguo@hsc.wvu.edu [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506-9190 (United States)

2011-08-15T23:59:59.000Z

216

Clinical Cancer Care Full screening services and diagnostics  

E-Print Network [OSTI]

Clinical Cancer Care · Full screening services and diagnostics · Advanced treatments for all forms of cancer · Most frequent cancers at the Cancer Center: Breast 15% Gastrointestinal 13% Skin 17% Lung 13 treatment protocols that link the latest Cancer Center research to clinical care · Familial Cancer Program

Myers, Lawrence C.

217

A Phase II Comparative Study of Gross Tumor Volume Definition With or Without PET/CT Fusion in Dosimetric Planning for Non-Small-Cell Lung Cancer (NSCLC): Primary Analysis of Radiation Therapy Oncology Group (RTOG) 0515  

SciTech Connect (OSTI)

Background: Radiation Therapy Oncology Group (RTOG) 0515 is a Phase II prospective trial designed to quantify the impact of positron emission tomography (PET)/computed tomography (CT) compared with CT alone on radiation treatment plans (RTPs) and to determine the rate of elective nodal failure for PET/CT-derived volumes. Methods: Each enrolled patient underwent definitive radiation therapy for non-small-cell lung cancer ({>=}60 Gy) and had two RTP datasets generated: gross tumor volume (GTV) derived with CT alone and with PET/CT. Patients received treatment using the PET/CT-derived plan. The primary end point, the impact of PET/CT fusion on treatment plans was measured by differences of the following variables for each patient: GTV, number of involved nodes, nodal station, mean lung dose (MLD), volume of lung exceeding 20 Gy (V20), and mean esophageal dose (MED). Regional failure rate was a secondary end point. The nonparametric Wilcoxon matched-pairs signed-ranks test was used with Bonferroni adjustment for an overall significance level of 0.05. Results: RTOG 0515 accrued 52 patients, 47 of whom are evaluable. The follow-up time for all patients is 12.9 months (2.7-22.2). Tumor staging was as follows: II = 6%; IIIA = 40%; and IIIB = 54%. The GTV was statistically significantly smaller for PET/CT-derived volumes (98.7 vs. 86.2 mL; p < 0.0001). MLDs for PET/CT plans were slightly lower (19 vs. 17.8 Gy; p = 0.06). There was no significant difference in the number of involved nodes (2.1 vs. 2.4), V20 (32% vs. 30.8%), or MED (28.7 vs. 27.1 Gy). Nodal contours were altered by PET/CT for 51% of patients. One patient (2%) has developed an elective nodal failure. Conclusions: PET/CT-derived tumor volumes were smaller than those derived by CT alone. PET/CT changed nodal GTV contours in 51% of patients. The elective nodal failure rate for GTVs derived by PET/CT is quite low, supporting the RTOG standard of limiting the target volume to the primary tumor and involved nodes.

Bradley, Jeffrey, E-mail: jbradley@wustl.edu [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO (United States); Bae, Kyounghwa [Department of Statistics, RTOG, Philadelphia, PA (United States); Choi, Noah [Massachusetts General Hospital, Boston, MA (United States); Forster, Ken [H. Lee Moffitt Cancer Center, Tampa, FL (United States); Siegel, Barry A. [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO (United States); Brunetti, Jacqueline [Holy Name Medical Center, Teaneck, NJ (United States); Purdy, James [University of California at Davis, Davis, CA (United States); Faria, Sergio [McGill University, Montreal (Canada); Vu, Toni [Centre Hospitalier Universitaire de Montreal, Hospital Notre Dame, Montreal (Canada); Thorstad, Wade [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO (United States); Choy, Hak [University of Texas Southwestern, Dallas, TX (United States)

2012-01-01T23:59:59.000Z

218

Expression of Neural Cell Adhesion Molecule-related Sialoglycoprotein in Small Cell Lung Cancer and Neuroblastoma Cell Lines H69 and CHP-212  

Science Journals Connector (OSTI)

...delivery system of cholesteryl pullulan(CHP-HER2) Shigehisa Kitano Michiko Hirayama...Cholesteryl pullulan-HER2 protein complex (CHP-HER2) is a cancer vaccine with a novel...hydrophobized polysaccharides, pullulan (CHP) containing truncated recombinant HER2...

C. E. C. Kitty Moolenaar; Egbert J. Muller; Dick J. Schol; Carl G. Figdor; Elizabeth Bock; Dieter Bitter-Suermann; Rob J. A. M. Michalides

1990-02-15T23:59:59.000Z

219

Differences in KRAS Mutation Spectrum in Lung Cancer Cases between African Americans and Caucasians after Occupational or Environmental Exposure to Known Carcinogens  

Science Journals Connector (OSTI)

...It is known that combustion of menthol produces...polycyclic aromatic hydrocarbon; OR, odds ratio...Inventory Explorer, data source: 1999 data...mutations, and p53-heat shock 70 protein...polycyclic aromatic hydrocarbons. Cancer Res...and CYP1A1, aryl hydrocarbon receptor, and glutathione...

Jay D. Hunt; Anna Strimas; Julie E. Martin; Marilyn Eyer; Monica Haddican; Brian G. Luckett; Bernardo Ruiz; T. William Axelrad; Wayne L. Backes; and Elizabeth T. H. Fontham

2002-11-01T23:59:59.000Z

220

Exon 5 Polymorphisms in the O6-Alkylguanine DNA Alkyltransferase Gene and Lung Cancer Risk in Non–Smokers Exposed to Second-Hand Smoke  

Science Journals Connector (OSTI)

...Training Awards from the International Agency for Research...the management of the project. Requests for reprints...Cancer Epidemiology, International Agency for Research...Malats N., Camus-Radon A. M., Nyberg F...environmental carcinogens. | International Agency of Research...

Catherine Cohet; Stephane Borel; Fredrik Nyberg; Anush Mukeria; Irene Brüske-Hohlfeld; Vali Constantinescu; Simone Benhamou; Paul Brennan; Janet Hall; and Paolo Boffetta

2004-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Effects of Respiratory Motion on Passively Scattered Proton Therapy Versus Intensity Modulated Photon Therapy for Stage III Lung Cancer: Are Proton Plans More Sensitive to Breathing Motion?  

SciTech Connect (OSTI)

Purpose: To quantify and compare the effects of respiratory motion on paired passively scattered proton therapy (PSPT) and intensity modulated photon therapy (IMRT) plans; and to establish the relationship between the magnitude of tumor motion and the respiratory-induced dose difference for both modalities. Methods and Materials: In a randomized clinical trial comparing PSPT and IMRT, radiation therapy plans have been designed according to common planning protocols. Four-dimensional (4D) dose was computed for PSPT and IMRT plans for a patient cohort with respiratory motion ranging from 3 to 17 mm. Image registration and dose accumulation were performed using grayscale-based deformable image registration algorithms. The dose–volume histogram (DVH) differences (4D-3D [3D = 3-dimensional]) were compared for PSPT and IMRT. Changes in 4D-3D dose were correlated to the magnitude of tumor respiratory motion. Results: The average 4D-3D dose to 95% of the internal target volume was close to zero, with 19 of 20 patients within 1% of prescribed dose for both modalities. The mean 4D-3D between the 2 modalities was not statistically significant (P<.05) for all dose–volume histogram indices (mean ± SD) except the lung V5 (PSPT: +1.1% ± 0.9%; IMRT: +0.4% ± 1.2%) and maximum cord dose (PSPT: +1.5 ± 2.9 Gy; IMRT: 0.0 ± 0.2 Gy). Changes in 4D-3D dose were correlated to tumor motion for only 2 indices: dose to 95% planning target volume, and heterogeneity index. Conclusions: With our current margin formalisms, target coverage was maintained in the presence of respiratory motion up to 17 mm for both PSPT and IMRT. Only 2 of 11 4D-3D indices (lung V5 and spinal cord maximum) were statistically distinguishable between PSPT and IMRT, contrary to the notion that proton therapy will be more susceptible to respiratory motion. Because of the lack of strong correlations with 4D-3D dose differences in PSPT and IMRT, the extent of tumor motion was not an adequate predictor of potential dosimetric error caused by breathing motion.

Matney, Jason; Park, Peter C. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); The University of Texas Graduate School of Biomedical Sciences, Houston, Texas (United States); Bluett, Jaques [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chen, Yi Pei [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); The University of Texas Graduate School of Biomedical Sciences, Houston, Texas (United States); Liu, Wei; Court, Laurence E. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao, Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Li, Heng [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe, E-mail: rmohan@mdanderson.org [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2013-11-01T23:59:59.000Z

222

Also in This Issue 2 International Cancer  

E-Print Network [OSTI]

Also in This Issue 2 International Cancer Benchmarking Partnership 3 Improving Staging Information 4 Studying the Care of Older Prostate Cancer Patients (CARDI) 4 The Northern Ireland PSA Database 5 Lung Cancer Resection Rates 5 All Ireland Cancer Atlas 5 CaPPS Update 6 Living With and Beyond Prostate

Müller, Jens-Dominik

223

Abstract 4158: Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma from never smokers  

Science Journals Connector (OSTI)

...Presentations - Molecular and Genetic Epidemiology of Lung, Head and Neck, and Gastrointestinal Cancers Proceedings: AACR Annual...Lee 4 Duhee Bang 2 Byoung Chul Cho 1 1Yonsei Cancer Center, Brain Korea 21 PLUS Project for Medical Science, Yonsei University...

Han Sang Kim; Jin Woo Ahn; Jung-Ki Yoon; Soo Min Han; Hoon Jang; Sungho Eun; Hyo Sup Shim; Hyun Jung Kim; Dae Joon Kim; Jin G. Lee; Chang Young Lee; Mi Kyung Bae; Kyung Young Chung; Eun Young Kim; Ji Y. Jung; Se Kyu Kim; Joon Chang; Hye Ryun Kim; Joo Hang Kim; Ji Hyun Lee; Duhee Bang; Byoung Chul Cho

2014-10-01T23:59:59.000Z

224

Challenges and Opportunities in International Molecular Cancer Prevention Research: An ASPO Molecular Epidemiology and the Environment and International Cancer Prevention Interest Groups Report  

Science Journals Connector (OSTI)

...upper-gastrointestinal cancers, indoor air pollution, and lung cancer among Chinese...such as for the topic of indoor air pollution (14). Investigators should...cancer associated with indoor air pollution from solid-fuel combustion...

Meira Epplein; Roberd M. Bostick; Lina Mu; Shuji Ogino; Dejana Braithwaite; and Peter A. Kanetsky

2014-11-01T23:59:59.000Z

225

A modified hypoxia-based TCP model to investigate the clinical outcome of stereotactic hypofractionated regimes for early stage non-small-cell lung cancer (NSCLC)  

SciTech Connect (OSTI)

Purpose: Stereotactic body radiotherapy (SBRT) has been applied to lung tumors at different stages and sizes with good local tumor control (LC) rates. The linear quadratic model (LQM), in its basic formulation, does not seem to be appropriate to describe the response to radiotherapy for clinical trials, based on a few fractions. Thus, the main aim of this work was to develop a model, which takes into account the hypoxic cells and their reoxygenation. Methods: A parameter named B has been introduced in a modified tumor control probability (TCP) from LQM and linear-quadratic-linear model (LQLM), and represents the fraction of hypoxic cells that survive and become oxygenated after each irradiation. Based on published trials evaluating LC at 3 yr (LC3), values of B were obtained by maximum likelihood minimization between predicted TCP and clinical LC3. Two oxygen enhancement ratio (OER) parameter sets (1 and 2) from literature have been adopted to calculate the B-factors. Initial hypoxic cell fractions ({eta}{sub h}) from 0.05 to 0.50 were assumed. Log-likelihood (L) and Akaike information criterion (AIC) were determined in an independent clinical validation dataset. Results: The B-values of modified TCPs spanned the whole interval from 0 to 1, depending on the fractionation scheme (number of fractions and dose/fraction), showing a maximum (close to 1) at doses/fraction of 8-12 Gy. The B-values calculated using the OER parameter set 1 exhibited a smoother falloff than set 2. An analytical expression was derived to describe the B-value's dependence on the fractionation scheme. The R{sup 2}-adjusted values varied from 0.63 to 0.67 for LQ models and OER set 1 and from 0.75 to 0.78 for LQ model and OER set 2. Lower values of R{sup 2}-adjusted were found for LQLM and both OER sets. L and AIC, calculated using a fraction of {eta}{sub h} = 0.15 and the B-value from the authors analytical expression were higher than for other {eta}{sub h}-values, irrespective of model or OER set. Conclusions: The authors model allows to predict the clinical outcome associated with SBRT treatment, taking into account both direct killing and indirect vasculature or stromal damage.

Strigari, L.; Benassi, M.; Sarnelli, A.; Polico, R.; D'Andrea, M. [Laboratory of Medical Physics and Expert Systems, National Cancer Institute Regina Elena, 00144 Rome (Italy); Medical Physics Department, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei tumori, 47014 Meldola (Italy); Radiotherapy Department, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei tumori, 47014 Meldola (Italy); Laboratory of Medical Physics and Expert Systems, National Cancer Institute Regina Elena, 00144 Rome (Italy)

2012-07-15T23:59:59.000Z

226

Tumor volume changes on serial imaging with megavoltage CT for non-small-cell lung cancer during intensity-modulated radiotherapy: How reliable, consistent, and meaningful is the effect?  

SciTech Connect (OSTI)

Purpose: Adaptive radiotherapy allows treatment plan modification based on data obtained during treatment. Assessing volume changes during treatment is now possible with intratreatment imaging capabilities on radiotherapy devices. This study assesses non-small-cell lung cancer (NSCLC) volume changes during treatment with conformal intensity-modulated radiotherapy by evaluating serial megavoltage computed tomography (MVCT) scans, with a specific emphasis on the frequency, reliability, and meaningfulness of these changes. Methods and Materials: Megavoltage CTs were retrospectively reviewed for 25 patients treated with the TomoTherapy Hi-Art system at University of Wisconsin. Twenty-one patients received definitive radiotherapy, 4 with extracranial stereotactic radioablation (60 Gy in five fractions) and 17 on a dose-per-fraction escalation protocol (57-80.5 Gy in 25 fractions). Four patients were treated palliatively (22-30 Gy in 8 to 10 fractions). Gross tumor volumes were contoured on serial MVCTs at weekly intervals. Each patient had 4 to 25 scans, including at least one at the beginning, midway, and one at the end of treatment. Results: At completion of treatment, no patient demonstrated a complete response. Partial response occurred in 3 (12%) and marginal response was noted in 5 (20%). The remaining 17 patients (68%) showed stable disease. The minimum 'scorable threshold' for volume discrepancy between scans to account for interscan assessment variability was set at >25% volume change; 10 patients (40%) had >25% tumor regression. None of the patients treated ablatively or palliatively showed tumor regression during treatment. Conclusions: Although gross tumor regression during treatment may be objectively measured using MVCTs, substantial volumetric decrease occurs only in a minority. The clinical significance of this regression is questionable, because there is no way to document histologic tumor clearance, and therefore field reductions during radiotherapy cannot be recommended.

Siker, Malika L. [Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI (United States); Tome, Wolfgang A. [Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI (United States); Mehta, Minesh P. [Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI (United States)]. E-mail: Mehta@humonc.wisc.edu

2006-09-01T23:59:59.000Z

227

Incident Management | Department of Energy  

Energy Savers [EERE]

systems report cyber security incidents to JC3. JC3 Bulletins are distributed to the DOE community to notify sites of computer security vulnerabilities and recommended actions....

228

Liver Cancer in Atomic-bomb Survivors: Histological Characteristics and Relationships to Radiation and Hepatitis B and C Viruses  

Science Journals Connector (OSTI)

......the Semipalatinsk nuclear test site in Kazakhstan, where 37,200 residents received exposures...Placek, V. and Kunz, E. (1993) Radon exposure and cancers other than lung cancer...Samet, J.M. and Yao, S.X. (1995) Radon and cancers other than lung cancer in......

Toshiyuki Fukuhara; Gerald B. Sharp; Terumi Mizuno; Hideyo Itakura; Masami Yamamoto; Masayoshi Tokunaga; Shoji Tokuoka; John B. Cologne; Yasuyuki Fujita; Midori Soda; Kiyohiko Mabuchi

2001-06-01T23:59:59.000Z

229

Incident Response Planning for Selected Livestock Shows  

E-Print Network [OSTI]

was interviewed, and then data were transcribed and categorized to consensus. Nine themes arose including: background information, challenges, communication, example incidents, executing incident response, incident response planning, incident response training...

Tomascik, Chelsea Roxanne

2012-02-14T23:59:59.000Z

230

Reporting Incidents Of Security Concern  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

To enhance the Department of Energy (DOE) Incidents of Security Concern Reporting Program through more consistent reporting, better information tracking, and interactive coordination. DOE N 251.54, dated 07/08/03, extends this directive until 07/08/04. Cancels Deputy Secretary Glauthier memorandum, subject: Reporting Security Incidents, dated 9-7-99.

2001-04-03T23:59:59.000Z

231

Cyber Security Incident Management Manual  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The manual establishes minimum requirements for a structured cyber security incident detection and management process for detecting, identifying, categorizing, containing, reporting, and mitigating cyber security incidents involving DOE information and information systems operated by DOE or by contractors on behalf of the Department. No cancellations. Admin Chg 1 dated 9-1-09.

2009-01-08T23:59:59.000Z

232

Cyber Security Incident Management Manual  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The manual establishes minimum requirements for a structured cyber security incident detection and management process for detecting, identifying, categorizing, containing, reporting, and mitigating cyber security incidents involving DOE information and information systems operated by DOE or by contractors on behalf of the Department. No cancellations.

2009-01-08T23:59:59.000Z

233

E-Print Network 3.0 - asbestos-induced lung disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

would I know... I have it? A: Some of the early warning signs of lung cancer are: A cough that doesn't go away... These symptoms can also come from other diseases, so seeing...

234

E-Print Network 3.0 - abscessus lung disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

would I know... I have it? A: Some of the early warning signs of lung cancer are: A cough that doesn't go away... These symptoms can also come from other diseases, so seeing...

235

Deletions of 17p and p53 Mutations in Preneoplastic Lesions of the Lung  

Science Journals Connector (OSTI)

...Research Council (Spe cial Project: Applicazioni Cliniche...described, following the International System for Human Cytogenetic...of archival material of radon-associated lung cancer...1984. 11. ISCN. An International System for Human Cytogenetic...

Gabriella Sozzi; Monica Miozzo; Rosangela Donghi; Silvana Pilotti; Claudia T. Cariani; Ugo Pastorino; Giuseppe Della Porta; and Marco A. Pierotti

1992-11-01T23:59:59.000Z

236

Multimodality Imaging of IL-18–Binding Protein-Fc Therapy of Experimental Lung Metastasis  

Science Journals Connector (OSTI)

...constant beating, which has high demand for glucose. The lung of normal...fLuc-4T1 tumor burden lung; Daily administration maintained the...breast carcinoma progression. J Egypt Natl Cancer Inst 2005;17...IL-18bp-Fc (1 mg/kg) daily i.p. Bioluminescence imaging...

Qizhen Cao; Weibo Cai; Gang Niu; Lina He; and Xiaoyuan Chen

2008-10-01T23:59:59.000Z

237

Chapter 17 - Expenditure Incidence and Economy-Wide Incidence Studies  

Science Journals Connector (OSTI)

Abstract Chapter 17 has two distinct sets of topics. The first part offers an analysis of expenditure incidence that covers the incidence of transfer payments, decreasing cost services, and nonexclusive goods. The second part discusses economy-wide incidence studies. Highlighted are the Pechman and Okner sources and uses approach to tax incidence, computable general equilibrium models (briefly), the Auerbach and Kotlikoff analysis of tax incidence in a dynamic setting using an OLG model, and the Fullerton and Rodgers model of lifetime tax incidence. The Appendix to Chapter 17 on tax reform considers four broad-based tax reform proposals that are common in the economics literature, bringing together some theoretical results from previous chapters and then turning to other issues that are not discussed elsewhere in the text. These include whether income from capital should be taxed, Michael Kremer's call for aged-based marginal tax rates, and the general problem of commitment or time-inconsistency in second-best analysis with imperfect information.

Richard W. Tresch

2015-01-01T23:59:59.000Z

238

Fundamentals of Lung Auscultation  

Science Journals Connector (OSTI)

..."moist" or "dry") can be misleading with regard to the means by which rales (or crackles) are produced. "Crackle" can be defined acoustically and does not suggest any means or site of generation. The clinical characteristics of normal and adventitious sounds are summarized in Table 1, and the lung... Computer-assisted techniques allow detailed analysis of the acoustic and physiological aspects of lung sounds. This short review of classic lung sounds includes both audio clips and interpretations made in the light of modern pulmonary acoustics.

Bohadana A.Izbicki G.Kraman S.S.

2014-02-20T23:59:59.000Z

239

Computerized Accident Incident Reporting System  

Broader source: Energy.gov [DOE]

The Computerized Accident/Incident Reporting System is a database used to collect and analyze DOE and DOE contractor reports of injuries, illnesses, and other accidents that occur during DOE...

240

Cyber Security Incident Management Manual  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The manual establishes minimum requirements for a structured cyber security incident detection and management process for detecting, identifying, categorizing, containing, reporting, and mitigating cyber security incidents involving DOE information and information systems operated by DOE or by contractors on behalf of the Department. Admin Chg 1 dated 9-1-09; Admin Chg 2 dated 12-22-09. Canceled by DOE O 205.1B.

2009-01-08T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Cancer in Ireland 1994-2004: A comprehensive report  

E-Print Network [OSTI]

Cancer in Ireland 1994-2004: A comprehensive report A report of cancer incidence, mortality AT and Comber H. Cancer in Ireland 1994-2004: A comprehensive report. Northern Ireland Cancer Registry/National Cancer Registry, Ireland; 2009 #12;#12;NICR/NCRI Contents...i Contents Contents

Müller, Jens-Dominik

242

17/03/2006 Accepted in European Journal of Cancer Prevention Time Trends and Geographic Variations for Thyroid Cancer  

E-Print Network [OSTI]

17/03/2006 Accepted in European Journal of Cancer Prevention 1 Time Trends and Geographic Variations for Thyroid Cancer in New Caledonia, a Very High Incidence Area (1985-1999) Thérèse Truong1 mail: guenel@vjf.inserm.fr Running head: Incidence of thyroid cancer in New Caledonia #12

Paris-Sud XI, Université de

243

Cyber Incidents Involving Control Systems  

SciTech Connect (OSTI)

The Analysis Function of the US-CERT Control Systems Security Center (CSSC) at the Idaho National Laboratory (INL) has prepared this report to document cyber security incidents for use by the CSSC. The description and analysis of incidents reported herein support three CSSC tasks: establishing a business case; increasing security awareness and private and corporate participation related to enhanced cyber security of control systems; and providing informational material to support model development and prioritize activities for CSSC. The stated mission of CSSC is to reduce vulnerability of critical infrastructure to cyber attack on control systems. As stated in the Incident Management Tool Requirements (August 2005) ''Vulnerability reduction is promoted by risk analysis that tracks actual risk, emphasizes high risk, determines risk reduction as a function of countermeasures, tracks increase of risk due to external influence, and measures success of the vulnerability reduction program''. Process control and Supervisory Control and Data Acquisition (SCADA) systems, with their reliance on proprietary networks and hardware, have long been considered immune to the network attacks that have wreaked so much havoc on corporate information systems. New research indicates this confidence is misplaced--the move to open standards such as Ethernet, Transmission Control Protocol/Internet Protocol, and Web technologies is allowing hackers to take advantage of the control industry's unawareness. Much of the available information about cyber incidents represents a characterization as opposed to an analysis of events. The lack of good analyses reflects an overall weakness in reporting requirements as well as the fact that to date there have been very few serious cyber attacks on control systems. Most companies prefer not to share cyber attack incident data because of potential financial repercussions. Uniform reporting requirements will do much to make this information available to Department of Homeland Security (DHS) and others who require it. This report summarizes the rise in frequency of cyber attacks, describes the perpetrators, and identifies the means of attack. This type of analysis, when used in conjunction with vulnerability analyses, can be used to support a proactive approach to prevent cyber attacks. CSSC will use this document to evolve a standardized approach to incident reporting and analysis. This document will be updated as needed to record additional event analyses and insights regarding incident reporting. This report represents 120 cyber security incidents documented in a number of sources, including: the British Columbia Institute of Technology (BCIT) Industrial Security Incident Database, the 2003 CSI/FBI Computer Crime and Security Survey, the KEMA, Inc., Database, Lawrence Livermore National Laboratory, the Energy Incident Database, the INL Cyber Incident Database, and other open-source data. The National Memorial Institute for the Prevention of Terrorism (MIPT) database was also interrogated but, interestingly, failed to yield any cyber attack incidents. The results of this evaluation indicate that historical evidence provides insight into control system related incidents or failures; however, that the limited available information provides little support to future risk estimates. The documented case history shows that activity has increased significantly since 1988. The majority of incidents come from the Internet by way of opportunistic viruses, Trojans, and worms, but a surprisingly large number are directed acts of sabotage. A substantial number of confirmed, unconfirmed, and potential events that directly or potentially impact control systems worldwide are also identified. Twelve selected cyber incidents are presented at the end of this report as examples of the documented case studies (see Appendix B).

Robert J. Turk

2005-10-01T23:59:59.000Z

244

Autoimmunity to Collagen in Human Lung Cancer  

Science Journals Connector (OSTI)

...24. Quesada, 3. R., Alexanian, R., Hawkins, M., Barlogie, B., Borden, E., Itri, L., and 125 " cnarges. inis article must therefore be hereby marked advertisement in accordance with ~- ~@ oe oe@ ~@ oe UJ@ uusquituus siivuiveitictlt...

Felix Fernandez-Madrid; Robert L. Karvonen; Michael J. Kraut; Barbara Czelusniak; Joel W. Ager

1996-01-01T23:59:59.000Z

245

Medical Progress: Lung Transplantation  

Science Journals Connector (OSTI)

...almost 90, but only 35 of these programs performed more than 10 transplantations in 1997 (Smith CM, United Network for Organ Sharing: personal communication). Accompanying the growth in activity has been an expansion of the spectrum of diseases for which transplantation can be offered. Currently, chronic... Since the performance of the first successful lung transplantation nearly two decades ago, the procedure has gained widespread acceptance as a therapeutic option for a diverse array of lung diseases. For patients with severe functional impairment and ...

Arcasoy S.M.; Kotloff R.M.

1999-04-08T23:59:59.000Z

246

E-Print Network 3.0 - aids cancer clinical Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cancer Society The American Lung... Center 1400 Jackson St. Denver, CO 80206-2761 Your Health Care Provider The National ... Source: National Center for Environmental Health-...

247

CCAAT Enhancer Binding Protein-? Regulates Matrix Metalloproteinase-1 Expression in Interleukin-1?–Stimulated A549 Lung Carcinoma Cells  

Science Journals Connector (OSTI)

...and progression of cancer in general, and lung cancer, in particular...carcinogens such as tobacco smoke, diesel exhaust, and radon, chronic...functions of CEBPB in the cell cycle. We found that LIP did not...whereas LIP may contribute to cell cycle aberrations in cancer cells...

David A. Armstrong; Lauren N. Phelps; and Matthew P. Vincenti

2009-09-01T23:59:59.000Z

248

LANL responds to radiological incident  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

LANL responds to radiological incident LANL responds to radiological incident LANL responds to radiological incident Multiple tests indicate no health risks to public or employees. August 27, 2012 Aerial view of the Los Alamos Neutron Science Center(LANSCE). Aerial view of the Los Alamos Neutron Science Center (LANSCE). The contamination poses no danger to the public. The Laboratory is investigating the inadvertent spread of Technetium 99 by employees and contractors at the Lujan Neutron Scattering Center August 27, 2012-The Laboratory is investigating the inadvertent spread of Technetium 99 by employees and contractors at the Lujan Neutron Scattering Center at the Los Alamos Neutron Science Center (LANSCE), a multidisciplinary accelerator facility used for both civilian and national security research. The Laboratory has determined that about a dozen people

249

aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer  

E-Print Network [OSTI]

--22000000 58 Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer

Paxton, Anthony T.

250

Lung pair phantom  

DOE Patents [OSTI]

The present invention is a material and method of making the material that exhibits improved radiation attenuation simulation of real lungs, i.e., an "authentic lung tissue" or ALT phantom. Specifically, the ALT phantom is a two-part polyurethane medium density foam mixed with calcium carbonate, potassium carbonate if needed for K-40 background, lanthanum nitrate, acetone, and a nitrate or chloride form of a radionuclide. This formulation is found to closely match chemical composition and linear attenuation of real lungs. The ALT phantom material is made according to established procedures but without adding foaming agents or preparing thixotropic concentrate and with a modification for ensuring uniformity of density of the ALT phantom that is necessary for accurate simulation. The modification is that the polyurethane chemicals are mixed at a low temperature prior to pouring the polyurethane mixture into the mold.

Olsen, Peter C. (West Richland, WA); Gordon, N. Ross (Kennewick, WA); Simmons, Kevin L. (Kennewick, WA)

1993-01-01T23:59:59.000Z

251

Cyber Security Incidents, Information Technology Division, ITD  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Reporting Computing Security Incidents Reporting Computing Security Incidents Incident Reporting Hotline: 631-344-8484 Security Incidents A computer security incident can range from a simple virus to the disclosure of sensitive information. Incidents can be minor, important, or significant. Incidents that must be reported include computer or network related activity, internal or external to the Laboratory, that may impact the Laboratory's mission. Examples of such activities include: the possibility of: loss of data; denial of services; compromise of computer security; unauthorized access to data that the Laboratory is required to control by law, regulation, or DOE orders; investigative activity by legal, law enforcement, bureaucratic, or political authorities; or a public relations embarrassment.

252

Polymorphisms in the Two Helicases ERCC2/XPD and ERCC3/XPB of the Transcription Factor IIH Complex and Risk of Lung Cancer: A Case-Control Analysis in a Chinese Population  

Science Journals Connector (OSTI)

...State Key Laboratory of Genetic Engineering, School of Life Sciences...smokers, and those with family history of cancer, particularly for...and environmental exposure history, including tobacco smoking...distribution of the controls. Family history of cancer was defined as any...

Zhibin Hu; Liang Xu; Minhua Shao; Jing Yuan; Yi Wang; Feng Wang; Wentao Yuan; Ji Qian; Hongxia Ma; Ying Wang; Hongliang Liu; Weihong Chen; Lin Yang; Guangfu Jing; Xiang Huo; Feng Chen; Li Jin; Qingyi Wei; Tangchun Wu; Daru Lu; Wei Huang; and Hongbing Shen

2006-07-01T23:59:59.000Z

253

Radon and Lung Cancer in the American Cancer Society Cohort  

Science Journals Connector (OSTI)

...prospective study in the general population. Ruano-Ravina...formaldehyde, and diesel engine exhaust), as well as...cohort (18, 34). General relative risk models...linear or log-linear general relative risk models...

Michelle C. Turner; Daniel Krewski; Yue Chen; C. Arden Pope III; Susan Gapstur; and Michael J. Thun

2011-03-01T23:59:59.000Z

254

Radon and Lung Cancer in the American Cancer Society Cohort  

Science Journals Connector (OSTI)

...Porstendorfer J , Reineking A.Radon: characteristics in...conversion coefficients for radon progeny for different...Epidemiology Reanalysis Project.Cambridge, MA:Health...Health Organization.International classification of diseases...gov/IEP/high-radon/files.html . 24...

Michelle C. Turner; Daniel Krewski; Yue Chen; C. Arden Pope III; Susan Gapstur; and Michael J. Thun

2011-03-01T23:59:59.000Z

255

Abstract 4188: Evolutionary dynamics in breast cancer via MRI textural kinetic analysis  

Science Journals Connector (OSTI)

...2013; Washington, DC Abstract 1930: The unknown piece of the pie: Molecular markers in triple-negative lung cancer. Brock...Stephan W. Morris, David R. Hout. The unknown piece of the pie: Molecular markers in triple-negative lung cancer. [abstract...

Jennifer S. Drukteinis; Baishali Chaudhury; Lawrence O. Hall; Dmitry B. Goldgof; Robert Gillies; Robert A. Gatenby

2014-10-01T23:59:59.000Z

256

Nuclear Incident Team | National Nuclear Security Administration  

National Nuclear Security Administration (NNSA)

Incident Team | National Nuclear Security Administration People Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing...

257

New Mechanism Based Anticancer Drugs for Treatment of Pancreatic and Bladder Cancers  

E-Print Network [OSTI]

-1977. The increase in survival is due to progress in diagnosing certain cancers at an earlier stage and improvements in treatment. ___________ This dissertation follows the style of Cancer Research. 2 Survival statistics vary greatly by country/region, cancer... bladder are most common and account for about 50% of all newly diagnosed cancers. The three most commonly diagnosed types of cancer among women in 2009 are cancers of the breast, lung and bronchus, and colon and rectum which accounting for 51...

Jutooru, Indira Devi

2011-08-08T23:59:59.000Z

258

A Multilevel Model of Postmenopausal Breast Cancer Incidence  

Science Journals Connector (OSTI)

...focus on single causal agents obscures the reality of a complex web of causation (2). Individuals in the general public still...Health 1996;17:47-67. 2. Krieger N .Epidemiology and the web of causation: has anyone seen the spider?Soc Sci Med 1994...

Robert A. Hiatt; Travis C. Porco; Fengchen Liu; Kaya Balke; Allan Balmain; Janice Barlow; Dejana Braithwaite; Ana V. Diez-Roux; Lawrence H. Kushi; Mark M. Moasser; Zena Werb; Gayle C. Windham; David H. Rehkopf

2014-10-01T23:59:59.000Z

259

Global Patterns of Cancer Incidence and Mortality Rates and Trends  

Science Journals Connector (OSTI)

...indoor air pollution from unventilated coal-fueled stoves and from cooking fumes...into action according to capacity and economic development (180-182). In economically...Spain (1992-2003): gender and socio-economic determinants. Public Health Nutr 2007...

Ahmedin Jemal; Melissa M. Center; Carol DeSantis; and Elizabeth M. Ward

2010-08-01T23:59:59.000Z

260

Definition: Angle of incidence | Open Energy Information  

Open Energy Info (EERE)

Angle of incidence Angle of incidence Jump to: navigation, search Dictionary.png Angle of incidence In reference to solar energy systems: the angle a ray of sun makes with a line perpendicular to a surface; for example, a surface directly facing the sun has an angle of incidence of zero, and a surface parallel to the sun (such as a sunrise striking a horizontal rooftop) has an angle of incidence of 90°. Sunlight with an incident angle of 90° tends to be absorbed, while lower angles tend to be reflected.[1][2] View on Wikipedia Wikipedia Definition Angle of incidence is a measure of deviation of something from "straight on", for example: in the approach of a ray to a surface, or the angle at which the wing or horizontal tail of an airplane is installed on the fuselage, measured relative to the axis of the fuselage.

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

JC3 Incident Reporting | Department of Energy  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Management » JC3 Incident Reporting Management » JC3 Incident Reporting JC3 Incident Reporting JC3 Incident Reporting Procedures U.S. Department of Energy Facilities/Contractors Only DOE O 205.1-B Chg 2 4.(c)(13) DEPARTMENT OF ENERGY CYBER SECURITY PROGRAM requires a defined "process for incident reporting that requires all cyber security incidents involving information or information systems, including privacy breaches, under DOE or DOE contractor control must be identified, mitigated, categorized, and reported to the Joint Cybersecurity Coordination Center (JC3) in accordance with JC3 procedures and guidance." This document outlines the referenced JC3 reporting procedures and guidance to facilitate your reporting and CIRC's response activity. CIRC should be informed of all reportable cyber security incidents as specified below.

262

Cyber Incident Information | Department of Energy  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Services » Guidance » Privacy » Cyber Incident Information Services » Guidance » Privacy » Cyber Incident Information Cyber Incident Information July 2013 Cyber Incident The Department of Energy has confirmed a cyber incident that occurred at the end of July and resulted in the unauthorized disclosure of federal employee Personally Identifiable Information (PII). January 2013 Cyber Incident The Department of Energy (DOE) has confirmed a cyber incident that occurred in mid-January 2013 which targeted the Headquarters' network and resulted in the unauthorized disclosure of employee and contractor Personally Identifiable Information (PII). Tips to Monitor Your Identity Here is a suggested list of tips to monitor and protect yourself. Assistive Technology Forms Guidance Capital Planning Information Collection Management

263

Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice  

Science Journals Connector (OSTI)

Lung cancer is the foremost cause of cancer mortality and is a growing economic burden worldwide. Fisetin (3,7,3?,4?-tetrahydroxyflavone), a naturally occurring flavonoid is found in vegetables and fruits possesses anti-oxidative, anti-inflammatory and anti-proliferative effects in a wide variety of cancer. In the present study it is hypothesized that fisetin may provide chemopreventive as well as chemotherapeutic effects against experimental lung carcinogenesis. The present study was designed to investigate whether fisetin confers anti-cancer action against benzo(a)pyrene [B(a)P] induced lung carcinogenesis. Treatment with fisetin significantly reduced the degree of histological lesions, restored the levels of lipid peroxidation (LPO), enzymic and non-enzymic anti-oxidants in B(a)P-induced mice. Anti-proliferative efficacy of fisetin was assessed by immunohistochemical analysis of proliferating cell nuclear antigen (PCNA) in B(a)P induced mice showed increased PCNA expression which is restored upon fisetin administration. Together, our results depicts that fisetin can be used as chemopreventive agent against lung cancer.

Nagaiya Ravichandran; Gopalakrishnan Suresh; Balasubramanian Ramesh; Ganesan Vijaiyan Siva

2011-01-01T23:59:59.000Z

264

Treating radiation-induced trismus in head and neck cancer;Exercise intervention and risk structures.  

E-Print Network [OSTI]

??Abstract The overall aim of this thesis was to investigate the incidence of trismus in head and neck cancer (HNC) and to assess the treatment… (more)

Pauli, Nina

2015-01-01T23:59:59.000Z

265

Thyroid cancer around Chernobyl  

SciTech Connect (OSTI)

The author`s presentation on thyroid cancer around Chernobyl will focus on four different things. First will be the time trends, or the pattern of thyroid cancer occurrence before and after the accident. It is now very well known that the increase in thyroid cancer in children in several areas has been unprecedented. Second, the author discusses thyroid cancer in general and patterns of thyroid cancer around the world before the Chernobyl accident, including differences by age and pathology. Third, the author presents relatively crude analyses of risk according to dose to the thyroid gland. And last, the author attempts to contrast the findings for thyroid cancer in relation to the internal radioiodine dose in Chernobyl studies with analyses of the effects of external dose on thyroid cancer incidence. The bottom line to be developed is similar to that presented by Elaine Ron with regard to effects of external dose on thyroid cancer. The similarities between the childhood finding from Chernobyl studies and external radiation studies appear more remarkable than the differences.

Beral, V. [Univ. of Oxford (United Kingdom)

1997-03-01T23:59:59.000Z

266

ORISE: The Medical Aspects of Radiation Incidents  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

discussed in The Medical Aspects of Radiation Incidents are: basic health physics and dose estimation (US and SI units) treatment of whole body and acute local irradiation issues...

267

Abstract PR12: Nuclear HSET, a predictor for metastasis, disease relapse, and poor survival, is a racial disparity biomarker in triple-negative breast cancer patients  

Science Journals Connector (OSTI)

...end-directed kinesin that has recently been implicated in carcinogenesis. HSET overexpression predicts lung cancer metastasis to the brain, and HSET is upregulated in triple-negative (TN) breast cancer that most commonly occurs in African American (AA) patients...

Angela Ogden; Gabriela Oprea-Ilies; Padmashree CG Rida; Dana Nickleach; Yuan Liu; Guilherme Cantuaria; Ritu Aneja

2014-11-01T23:59:59.000Z

268

Radon and the risks of cancer  

Science Journals Connector (OSTI)

... of April, Denis Henshaw and colleagues1 published their finding of significant correlations between average indoor radon levels in different countries and the incidence of leukaemia and other cancers in children, ... a similar correlation for prostatic cancer2. Significant regional correlations have also been reported between indoor radon and acute myeloid leukaemia in Britain3 and Canada1.

Julian Peto

1990-05-31T23:59:59.000Z

269

Recurrence of Lung Adenocarcinoma After an Interval of 15 Years Revealed by Demonstration of the Same Type of EML4–ALK Fusion Gene  

Science Journals Connector (OSTI)

Abstract We carried out an experiment on a 58-year-old man with multiple left lung tumors and swelling of multiple lymph nodes. For clinical staging and therapeutic purposes, bronchoalveolar lavage (BAL) cytology and lung biopsy were performed. The biopsy specimen revealed the left lower lung mass to be immunohistochemically ALK (anaplastic lymphoma kinase)-positive adenocarcinoma. Using the BAL specimen from the left lower lung, EML4 (echinoderm microtubule-associated protein-like 4)-ALK variant 1 fusion gene was detected by reverse transcription-polymerase chain reaction (RT-PCR). His past history showed that he had undergone an operation for lung adenocarcinoma of the right lower lobe 15 years before, and the pathological specimen at that time revealed that the lung adenocarcinoma with pleural invasion and single metastasis of mediastinal lymph node showed a mucinous cribriform pattern and/or signet-ring cell pattern. The typical histology led us to examine the ALK rearrangement in the primary lung cancer and mediastinal metastatic tumor. Immunohistochemistry (IHC) for ALK was positive, and ALK break apart fluorescence in situ hybridization (FISH) showed a positive result. Moreover, RT-PCR using formalin-fixed, paraffin-embedded tissue from the right lung cancer also demonstrated EML4–ALK variant 1 fusion gene. Although there is a possibility that the left lung cancer is de novo one with multiple metastases, detection of the same fusion gene of the very rare EML4–ALK variant 1 in both tumors suggests that the left cancer is a recurrence of the right lung cancer after an interval of 15 years.

Yoshitane Tsukamoto; Kiyonobu Kanamori; Takahiro Watanabe; Koji Mikami; Ryuji Ieki; Takashi Nakano; Kazuyoshi Kajimoto; Seiichi Hirota

2014-01-01T23:59:59.000Z

270

Radiation prevents much cancer  

Science Journals Connector (OSTI)

Evidence reviewed here supports the concept that chronic exposure to ionising radiation can dramatically decrease cancer incidence and mortality. This evidence includes an inverse relationship between radiation levels and cancer induction and/or mortality in: over 200 million people in the USA; 200 million people in India; 10,000 residents of Taipei who live in cobalt-60 contaminated homes; high radiation areas of Ramsar, Iran; 12 million person-years of exposed and carefully selected control nuclear workers; almost 300,000 homes with radon in the USA; non-smokers in high radon areas of Saxony, Germany.

T.D. Luckey

2007-01-01T23:59:59.000Z

271

142pr glass seeds for the brachytherapy of prostate cancer  

E-Print Network [OSTI]

....................................................... 48 V-1 Preparation of experiment................................................................... 48 V-2 Nuclear Science Center Reactor (NSCR)........................................... 51 V-3 Neutron activation... Society 2006), after skin cancer, and the second leading cause of cancer-related death in men in the United States. Between 1988 and 1992, prostate cancer incidence rates increased dramatically due to earlier diagnosis with prostate-specific antigen...

Jung, Jae Won

2007-09-17T23:59:59.000Z

272

Dynamic detection of nuclear reactor core incident  

Science Journals Connector (OSTI)

Surveillance, safety and security of evolving systems are a challenge to prevent accident. The dynamic detection of a hypothetical and theoretical blockage incident in the Phenix nuclear reactor is investigated. Such an incident is characterized by abnormal ... Keywords: Contrast, Dynamic detection of perturbations, Evolving system, Fast-neutron reactor, Neighbourhood, Noise

Laurent Hartert; Danielle Nuzillard; Jean-Philippe Jeannot

2013-02-01T23:59:59.000Z

273

Chapter_11_Incidents_of_Security_Concern  

Broader source: Energy.gov (indexed) [DOE]

1 1 Incidents of Security Concern This chapter covers the DOE HQ implementation of DOE Order 470.4B, Safeguards and Security Program, Attachment 5, Incidents of Security Concern. HS-91 manages the HQ Security Incidents Program. Incidents of Security Concern (henceforth referred to as Incidents) are actions, inactions, or events that are believed to: * Pose threats to national security interests and/or DOE assets * Create potentially serious or dangerous security situations * Significantly affect the safeguards and security program's capability to protect DOE safeguards and security interests * Indicate failure to adhere to security procedures * Reveal that the system is not functioning properly, by identifying and/or mitigating potential threats (e.g., detecting suspicious activity, hostile acts, etc.).

274

ORISE: Incident Command System (ICS) Training  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Incident Command System (ICS) Training Incident Command System (ICS) Training The Oak Ridge Institute for Science and Education (ORISE) supports the emergency response community by promoting interagency cooperation and developing training that enhances response efforts. An example of such support involves the U.S. Department of Energy (DOE) Office of Emergency Response and its compliance efforts toward the Homeland Security Presidential Directive-5 (HSPD-5), which includes the implementation of National Incident Management System (NIMS)/Incident Command System (ICS) and the National Response Framework (NRF). The ICS, which has been recognized for its training curricula that has exceeded national standards, is an on-scene, all-hazard incident management concept that was originally designed for emergency management agencies, but

275

Methylenetetrahydrofolate reductase (MTHFR) and risk of breast cancer: The Western New York Exposures and Breast Cancer Study (WEB Study)  

Science Journals Connector (OSTI)

...risk of breast cancer: The Western New York Exposures and Breast Cancer Study...study in two counties of western New York. Cases were women with primary incident...adjusted for age, education, total energy and other nutrient and breast cancer...

Mary E. Platek; Jo L. Freudenheim; Sylvia Quick; Jing Nie; Paola Muti; Susan E. McCann; Maurizio Trevisan; Peter Shields; and Stephen B. Edge

2005-05-01T23:59:59.000Z

276

Incident Report An incident report should be submitted for any event involving  

E-Print Network [OSTI]

Incident Report An incident report should be submitted for any event involving: injury or illness fire explosion or implosion chemical exposure Minor cuts and scrapes need not be reported be reported. If a "near miss" might have had severe consequences, submit an incident report. You may also

Crawford, T. Daniel

277

Lung Adenocarcinoma Incidence Rates and Their Relation to Motor Vehicle Density  

Science Journals Connector (OSTI)

...with about one motor vehicle per square mile...study design. In ecological studies, none of...as follows: As an ecological study, the data of motor vehicle density was obtained...individuals; that is, the ecological fallacy could not...

Fan Chen; Haley Jackson; and William F. Bina

2009-03-01T23:59:59.000Z

278

Early detection of ovarian cancer using group biomarkers  

Science Journals Connector (OSTI)

...West J, Franklin W, et al. Altered HOX and WNT7A expression in human lung cancer. Proc Natl Acad Sci U S A 2000;97:12776-81. 29 Bouchard D, Morisset D, Bourbonnais Y, Tremblay GM. Proteins with whey-acidic-protein motifs and cancer...

Alain B. Tchagang; Ahmed H. Tewfik; Melissa S. DeRycke; Keith M. Skubitz; Amy P.N. Skubitz

2008-01-01T23:59:59.000Z

279

RESEARCH Open Access Analysis of primary risk factors for oral cancer  

E-Print Network [OSTI]

RESEARCH Open Access Analysis of primary risk factors for oral cancer from select US states , Michelle Chino3 , Karl Kingsley1* Abstract Objectives: To examine the primary risk factor for oral cancer in oral cancer incidence and mortality. Methods: Population-based data on oral cancer morbidity

Ahmad, Sajjad

280

Aging Impacts Transcriptome but not Genome of Hormone-dependentBreast Cancers  

SciTech Connect (OSTI)

Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age-at-diagnosis has been shown to be an independent indicator of breast cancer prognosis. However, except for inherited forms of breast cancer, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior.

Yau, Christina; Fedele, Vita; Roydasgupta, Ritu; Fridlyand, Jane; Hubbard, Alan; Gray, Joe W.; Chew, Karen; Dairkee, Shanaz H.; Moore, DanH.; Schittulli, Francesco; Tommasi, Stefania; Paradiso, Angelo; Albertson, Donna G.; Benz, Christopher C.

2007-10-09T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Incident Prevention, Warning, and Response (IPWAR) Manual  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This Manual defines a structured, cohesive, and consistent process for performing incident prevention, warning, and response for DOE's Federal information systems and is consistent with the requirements of Federal laws, Executive orders, national security directives, and other regulations. The Manual also provides requirements and implementation instructions for the Department's Incident Prevention, Warning and Response process, and supplements DOE O 205.1, Department of Energy Cyber Security Management Program, dated 3-21-03. DOE N 205.17 cancels this manual. This manual cancels DOE N 205.4, Handling Cyber Security Alerts and Advisories and Reporting Cyber Security Incidents, dated 3/18/2002.

2004-09-30T23:59:59.000Z

282

Green Tea and Gastric Cancer  

Science Journals Connector (OSTI)

...People in Japan have welcomed these findings, and green tea is widely viewed as a healthful beverage. Indeed, it no longer needs to be prepared in a teapot at home. Canned or bottled green tea is now widely available in vending machines and convenience stores throughout Japan, along with soft drinks and... Gastric cancer was once the leading cause of cancer-related death in most countries, including the United States. Since 1930 the incidence of gastric cancer has steadily decreased throughout the world, with dramatic decreases in the West. In 1994, gastric ...

Sano T.; Sasako M.

2001-03-01T23:59:59.000Z

283

Definition: Cyber Security Incident | Open Energy Information  

Open Energy Info (EERE)

Security Incident Security Incident Jump to: navigation, search Dictionary.png Cyber Security Incident Any malicious act or suspicious event that: Compromises, or was an attempt to compromise, the Electronic Security Perimeter or Physical Security Perimeter of a Critical Cyber Asset, or, Disrupts, or was an attempt to disrupt, the operation of a Critical Cyber Asset.[1] Related Terms Electronic Security Perimeter References ↑ Glossary of Terms Used in Reliability Standards An LikeLike UnlikeLike You like this.Sign Up to see what your friends like. inline Glossary Definition Retrieved from "http://en.openei.org/w/index.php?title=Definition:Cyber_Security_Incident&oldid=480296" Categories: Definitions ISGAN Definitions What links here Related changes Special pages Printable version

284

General surface equations for glancing incidence telescopes  

Science Journals Connector (OSTI)

A generalized set of equations are derived for two mirror glancing incidence telescopes using Fermat’s principle, a differential form of the law of reflection, the generalized sine...

Saha, Timo T

1987-01-01T23:59:59.000Z

285

Radioactive Materials Transportation and Incident Response  

Broader source: Energy.gov (indexed) [DOE]

FEMA 358, 05/10 FEMA 358, 05/10 Q A RADIOACTIVE MATERIALS Transportation Emergency Preparedness Program U.S. Department of Energy TRANSPORTATION AND INCIDENT RESPONSE Q&A About Incident Response Q Q Law Enforcement ____________________________________ Fire ___________________________________________ Medical ____________________________________________ State Radiological Assistance ___________________________ Local Government Official ______________________________ Local Emergency Management Agency ___________________ State Emergency Management Agency ___________________ HAZMAT Team ______________________________________ Water Pollution Control ________________________________ CHEMTEL (Toll-free US & Canada) 1-800-255-3924 _________ CHEMTREC (Toll-free US & Canada) 1-800-424-9300 _______

286

Establishing and operating an incident response team  

SciTech Connect (OSTI)

Occurrences of improprieties dealing with computer usage are on the increase. They range all the way from misuse by employees to international computer telecommunications hacking. In addition, natural disasters and other disasters such as catastrophic fires may also fall into the same category. These incidents, like any other breach of acceptable behavior, may or may not involve actual law breaking. A computer incident response team should be created as a first priority. This report discusses the establishment and operation of a response team.

Padgett, K.M.

1992-09-01T23:59:59.000Z

287

Establishing and operating an incident response team  

SciTech Connect (OSTI)

Occurrences of improprieties dealing with computer usage are on the increase. They range all the way from misuse by employees to international computer telecommunications hacking. In addition, natural disasters and other disasters such as catastrophic fires may also fall into the same category. These incidents, like any other breach of acceptable behavior, may or may not involve actual law breaking. A computer incident response team should be created as a first priority. This report discusses the establishment and operation of a response team.

Padgett, K.M.

1992-01-01T23:59:59.000Z

288

National Heart, Lung, and Blood Institute  

E-Print Network [OSTI]

National Heart, Lung, and Blood Institute A T - A - G L A N C E : Asthma A sthma is a chronic Heart, Lung, and Blood Institute (NHLBI) Web site at www.nhlbi.nih.gov (under Health Information

Bandettini, Peter A.

289

Novel applications of data mining methodologies to incident databases  

E-Print Network [OSTI]

Incident databases provide an excellent opportunity to study the repeated situations of incidents in the process industry. The databases give an insight into the situation which led to an incident, and if studied properly can help monitor...

Anand, Sumit

2006-08-16T23:59:59.000Z

290

Princess Takamatsu Symposium on DNA Repair and Human Cancers  

Science Journals Connector (OSTI)

...the incidence of cancer throughout the world. Princess Takamatsu helped to organize...not become immortal to high-LET (low energy transfer) radiation. These cells showed...populations. Stanton Gerson (Case Western Reserve University, Cleveland, OH) analyzed...

Lawrence A. Loeb and Susumu Nishimura

2010-06-01T23:59:59.000Z

291

Risk assessment of mortality for all-cause, ischemic heart disease, cardiopulmonary disease, and lung cancer due to the operation of the world's largest coal-fired power plant  

Science Journals Connector (OSTI)

Abstract Based on recent understanding of PM2.5 health-related problems from fossil-fueled power plants emission inventories collected in Taiwan, we have determined the loss of life expectancy (LLE) and the lifetime (75-year) risks for PM2.5 health-related mortalities as attributed to the operation of the world's largest coal-fired power plant; the Taichung Power Plant (TCP), with an installed nominal electrical capacity of 5780 MW in 2013. Five plausible scenarios (combinations of emission controls, fuel switch, and relocation) and two risk factors were considered. It is estimated that the lifetime (75-y) risk for all-cause mortality was 0.3%–0.6% for males and 0.2%–0.4% for females, and LLE at 84 days in 1997 for the 23 million residents of Taiwan. The risk has been reduced to one-fourth at 0.05%–0.10% for males and 0.03%–0.06% for females, and LLE at 15 days in 2007, which was mainly attributed to the installation of desulfurization and de-NOx equipment. Moreover, additional improvements can be expected if we can relocate the power plant to a downwind site on Taiwan, and convert the fuel source from coal to natural gas. The risk can be significantly reduced further to one-fiftieth at 0.001%–0.002% for males and 0.001% for females, and LLE at 0.3 days. Nonetheless, it is still an order higher than the commonly accepted elevated-cancer risk at 0.0001% (10?6), indicating that the PM2.5 health-related risk for operating such a world-class power plant is not negligible. In addition, this study finds that a better-chosen site (involving moving the plant to the leeward side of Taiwan) can reduce the risk significantly as opposed to solely transitioning the fuel source to natural gas. Note that the fuel cost of using natural gas (0.11 USD/kWh in 2013) in Taiwan is about twice the price of using coal fuel (0.05 USD/kWh in 2013).

Pei-Hsuan Kuo; Ben-Jei Tsuang; Chien-Jen Chen; Suh-Woan Hu; Chun-Ju Chiang; Jeng-Lin Tsai; Mei-Ling Tang; Guan-Jie Chen; Kai-Chen Ku

2014-01-01T23:59:59.000Z

292

Y90-Radioembolization of Lung Metastases via the Bronchial Artery: A Report of 2 Cases  

SciTech Connect (OSTI)

We report successful Y90-radioembolization of the lung applying Y90-resin microspheres via the bronchial artery in two patients with diffuse colorectal and renal cancer metastases, respectively. The deposition of radioactive Y90-resin-microspheres was technically feasible and resulted in a reasonable absorbed dose in the tumors. However, open questions remain regarding dosimetry and safe dose exposure to the lung. The technique warrants thorough investigation before clinical use. A Phase I trial to evaluate safety and preliminary efficacy is under preparation.

Ricke, Jens, E-mail: jens.ricke@med.ovgu.de; Grosser, Oliver; Amthauer, Holger [Universitaetsklinikum Magdeburg AoeR, Klinik fuer Radiologie und Nuklearmedizin (Germany)] [Universitaetsklinikum Magdeburg AoeR, Klinik fuer Radiologie und Nuklearmedizin (Germany)

2013-12-15T23:59:59.000Z

293

Computerized Accident/Incident Reporting System  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Accident Recordkeeping and Reporting Accident Recordkeeping and Reporting Accident/Incident Recordkeeping and Reporting CAIRS logo Computerized Accident Incident Reporting System CAIRS Database The Computerized Accident/Incident Reporting System is a database used to collect and analyze DOE and DOE contractor reports of injuries, illnesses, and other accidents that occur during DOE operations. Injury and Illness Dashboard The Dashboard provides an alternate interface to CAIRS information. The initial release of the Dashboard allows analysis of composite DOE-wide information and summary information by Program Office, and site. Additional data feature are under development. CAIRS Registration Form CAIRS is a Government computer system and, as such, has security requirements that must be followed. Access to the

294

Implementation and evaluation of modified dynamic conformal arc (MDCA) technique for lung SBRT patients following RTOG protocols  

SciTech Connect (OSTI)

To implement modified dynamic conformal arc (MDCA) technique and Radiation Therapy Oncology Group (RTOG) protocols in our clinic for stereotactic body radiation therapy (SBRT) treatment of patients with Stage I/II non–small cell lung cancer. Five patients with non–small cell lung cancer have been treated with SBRT. All the patients were immobilized using CIVCO Body Pro-Lok system and scanned using GE 4-slice computed tomography. The MDCA technique that was previously published was adopted as our planning technique, and RTOG protocols for the lung SBRT were followed. The patients were treated on Novalis Tx system with cone-beam computed tomography imaging guidance. All the patient plans passed the RTOG criteria. The conformal index ranges from 0.99 to 1.12 for the planning target volume, and the biological equivalent dose for the planning target volume is overall 100 Gy. Critical structures (lung, spinal cord, brachial plexus, skin, and chest wall) also meet RTOG protocols or published data. A 6-month follow-up of one of the patients shows good local disease control. We have successfully implemented the MDCA technique into our clinic for the lung SBRT program. It shows that the MDCA is useful and efficient for the lung SBRT planning, with the plan quality meeting the RTOG protocols.

Shi, Chengyu, E-mail: shicy1974@gmail.com [St. Vincent's Medical Center, Bridgeport, CT (United States); Tazi, Adam; Fang, Deborah Xiangdong; Iannuzzi, Christopher [St. Vincent's Medical Center, Bridgeport, CT (United States)

2013-10-01T23:59:59.000Z

295

Computer-aided beam arrangement based on similar cases in radiation treatment-planning databases for stereotactic lung radiation therapy  

Science Journals Connector (OSTI)

......were evaluated by plan evaluation indices...the institutional review board of the University...an SBRT treatment plan for lung cancer...feature was divided by standard deviation of all...Table 1. Mean standard deviation of the plan evaluation indices......

Taiki Magome; Hidetaka Arimura; Yoshiyuki Shioyama; Asumi Mizoguchi; Chiaki Tokunaga; Katsumasa Nakamura; Hiroshi Honda; Masafumi Ohki; Fukai Toyofuku; Hideki Hirata

2013-05-01T23:59:59.000Z

296

Identification of a Novel Biomarker, SEMA5A, for Non–Small Cell Lung Carcinoma in Nonsmoking Women  

Science Journals Connector (OSTI)

...Department of Electrical Engineering, Graduate Institute of Biomedical...cancer patients in Taiwan have a history of smoking. The genetic mechanisms...and radiation), clinical history of lung diseases (e.g...ref. 3), familial tumor history (4), or diet (5, 6...

Tzu-Pin Lu; Mong-Hsun Tsai; Jang-Ming Lee; Chung-Ping Hsu; Pei-Chun Chen; Chung-Wu Lin; Jin-Yuan Shih; Pan-Chyr Yang; Chuhsing Kate Hsiao; Liang-Chuan Lai; and Eric Y. Chuang

2010-10-01T23:59:59.000Z

297

Bi-plane correlation imaging for improved detection of lung nodules Ehsan Samei1,2,3  

E-Print Network [OSTI]

approach that utilizes angular information from a bi-plane digital acquisition in conjunction with computer. The correlated suspect lesions were registered as positive. Using an optimum ­3o vertical geometry and processing. INTRODUCTION Lung cancer is a leading cause of death in the US, surpassing the mortality associated with breast

298

FM032_r1_0_Incident Report.doc 03/04/09 CNS Incident Report Form  

E-Print Network [OSTI]

FM032_r1_0_Incident Report.doc 03/04/09 CNS Incident Report Form Incident Information Date and Time Instructions on reverse #12;FM032_r1_0_Incident Report.doc 03/04/09 FM032 Instructions 1. This form. This form is not a substitute for other reporting obligations including University Injury reports. #12;

299

Estimating distribution of the age of onset of detectable asymptomatic cancer  

E-Print Network [OSTI]

Estimating distribution of the age of onset of detectable asymptomatic cancer Giovanni Parmigiani through the Specialized Program of Research Ex­ cellence (SPORE) grant in Breast Cancer at Duke University to estimate the distribution of the age of onset of detectable preclinical cancer, using incidence data

West, Mike

300

The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells  

Science Journals Connector (OSTI)

...Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer Yangsik...biomarkers and new therapeutic targets. Nuclear receptors are druggable targets due to...using publicly available microarray datasets, we found that the NR signature has a...

Syng-Ook Lee; Un-Ho Jin; Jeong Han Kang; Sang Bae Kim; Aaron S. Guthrie; Sandeep Sreevalsan; Ju-Seog Lee; and Stephen Safe

2014-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Electrically floating, near vertical incidence, skywave antenna  

DOE Patents [OSTI]

An Electrically Floating, Near Vertical Incidence, Skywave (NVIS) Antenna comprising an antenna element, a floating ground element, and a grounding element. At least part of said floating ground element is positioned between said antenna element and said grounding element. The antenna is separated from the floating ground element and the grounding element by one or more electrical insulators. The floating ground element is separated from said antenna and said grounding element by one or more electrical insulators.

Anderson, Allen A.; Kaser, Timothy G.; Tremblay, Paul A.; Mays, Belva L.

2014-07-08T23:59:59.000Z

302

Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs  

Science Journals Connector (OSTI)

Abstract Gadolinium (Gd) contrast agents are predominantly used for T1 MR imaging. However, the high toxicity of Gd3 + and potential side effects including nephrogenic systemic fibrosis have led to the search for alternative T1 contrast agents. Since manganese (Mn) has paramagnetic properties with five unpaired electrons that permit high spin number, long electronic relaxation times, and labile water exchange, we evaluated Mn as a T1 magnetic resonance imaging (MRI) contrast agent for lung imaging. Here we report on the design and synthesis of multifunctional lipid-micellar nanoparticles (LMNs) containing Mn oxide (M-LMNs) for MRI that can also be used for DNA and drug delivery. Oleic acid-coated MnO nanoparticles were encapsulated in micelles composed of polyethylene glycol (PEG-2000), phosphatidylethanolamine (PE), DC-cholesterol, and dioleoyl-phosphatidylethanolamine (DOPE). The particles are taken up in vitro by human embryonic kidney (HEK293), Lewis lung carcinoma (LLC1), and A549 cells and are devoid of cytotoxicity. When administered to mice intranasally, they preferentially accumulate in the lungs. In vitro phantom and ex vivo lung MRI results confirmed that M-LMNs are able to enhance T1 MRI contrast. M-LMNs loaded with plasmid DNA and/or doxorubicin are efficiently taken up by HEK293 cells in vitro and by target cells in vivo. Taken together, these results demonstrate that M-LMNs are capable of simultaneously providing MRI contrast and DNA and/or drug delivery to target cells in the lung and therefore may prove useful as a lung theranostic, especially for lung cancers.

M. Howell; J. Mallela; C. Wang; S. Ravi; S. Dixit; U. Garapati; S. Mohapatra

2013-01-01T23:59:59.000Z

303

Cough Detection and Forecasting for Radiation Treatment of Lung Cancer.  

E-Print Network [OSTI]

??In radiation therapy, a treatment plan is designed to make the delivery of radiation to a target more accurate, effective, and less damaging to surrounding… (more)

Qiu, Zigang Jimmy

2010-01-01T23:59:59.000Z

304

Building a comprehensive quantitative risk assessment model for lung cancer  

Science Journals Connector (OSTI)

...Res, Volume 46, 2005 Building a comprehensive quantitative...including identification of multi-collinearities and...and resulted in model multi-collinearities. When...asbestos exposure, family history of LC and years...factors of emphysema, family history of LC, years...

Carol J. Etzel; Qing Zhang; Matthew Schabath; Qiong Dong; Xifeng Wu; Qingyi Wei; Margaret Spitz; and Christopher I. Amos

2005-05-01T23:59:59.000Z

305

Clinical Issues in the Management of Early Lung Cancer  

Science Journals Connector (OSTI)

...collaborative approach incorporating...promotion and disease management interventions...and population sciences (45, 46...solution-oriented approach focused on improving...and integrated approach [e.g., Innovative...Prevention and management of symptoms in...PAR-13-165); Systems science and health in...

James L. Mulshine

2005-07-01T23:59:59.000Z

306

DNA Adducts and Lung Cancer Risk: A Prospective Study  

Science Journals Connector (OSTI)

...emitted primarily during combustion of fossil fuels by...polycyclic aromatic hydrocarbons, and particles. Science...Polycyclic aromatic hydrocarbon-DNA adducts in human...deaths during the 2003 heat wave in the Netherlands...polycyclic aromatic hydrocarbons from the US EPA priority...

Marco Peluso; Armelle Munnia; Gerard Hoek; Michal Krzyzanowski; Fabrizio Veglia; Luisa Airoldi; Herman Autrup; Alison Dunning; Seymour Garte; Pierre Hainaut; Christian Malaveille; Emmanuelle Gormally; Giuseppe Matullo; Kim Overvad; Ole Raaschou-Nielsen; Francoise Clavel-Chapelon; Jacob Linseisen; Heiner Boeing; Antonia Trichopoulou; Dimitrios Trichopoulos; Anna Kaladidi; Domenico Palli; Vittorio Krogh; Rosario Tumino; Salvatore Panico; H. Bas Bueno-De-Mesquita; Petra H. Peeters; Merethe Kumle; Carlos A. Gonzalez; Carmen Martinez; Miren Dorronsoro; Aurelio Barricarte; Carmen Navarro; J. Ramón Quiros; Goran Berglund; Lars Janzon; Bengt Jarvholm; Nicholas E. Day; Tim J. Key; Rodolfo Saracci; Rudolf Kaaks; Elio Riboli; and Paolo Vineis

2005-09-01T23:59:59.000Z

307

Prognostic Immune Markers in Non–Small Cell Lung Cancer  

Science Journals Connector (OSTI)

...protein 2 Chemotactic factor that attracts monocytes, lymphocytes, basophils, and eosinophils CCR2 (3p21.31) 0.0446 (0.9975) C-C chemokine receptor type 2 MCP 1 receptor Receptor for the MCP-1, 3, and 4 BST2 (19p13.1) 0.0468 (1.0002...

Kei Suzuki; Stefan S. Kachala; Kyuichi Kadota; Ronglai Shen; Qianxing Mo; David G. Beer; Valerie W. Rusch; William D. Travis; Prasad S. Adusumilli

2011-08-15T23:59:59.000Z

308

DNA Adducts and Lung Cancer Risk: A Prospective Study  

Science Journals Connector (OSTI)

...reactions involving hydrocarbons and nitrogen dioxide...primarily during combustion of fossil fuels...Besides, our data indicate a possible...polycyclic aromatic hydrocarbons, and particles...during the 2003 heat wave in the Netherlands...polycyclic aromatic hydrocarbons from the US EPA...

Marco Peluso; Armelle Munnia; Gerard Hoek; Michal Krzyzanowski; Fabrizio Veglia; Luisa Airoldi; Herman Autrup; Alison Dunning; Seymour Garte; Pierre Hainaut; Christian Malaveille; Emmanuelle Gormally; Giuseppe Matullo; Kim Overvad; Ole Raaschou-Nielsen; Francoise Clavel-Chapelon; Jacob Linseisen; Heiner Boeing; Antonia Trichopoulou; Dimitrios Trichopoulos; Anna Kaladidi; Domenico Palli; Vittorio Krogh; Rosario Tumino; Salvatore Panico; H. Bas Bueno-De-Mesquita; Petra H. Peeters; Merethe Kumle; Carlos A. Gonzalez; Carmen Martinez; Miren Dorronsoro; Aurelio Barricarte; Carmen Navarro; J. Ramón Quiros; Goran Berglund; Lars Janzon; Bengt Jarvholm; Nicholas E. Day; Tim J. Key; Rodolfo Saracci; Rudolf Kaaks; Elio Riboli; and Paolo Vineis

2005-09-01T23:59:59.000Z

309

Ambient air pollution exposure and the incidence of related health effects among racial/ethnic minorities  

SciTech Connect (OSTI)

Differences among racial and ethnic groups in morbidity and mortality rates for diseases, including diseases with environmental causes, have been extensively documented. However, documenting the linkages between environmental contaminants, individual exposures, and disease incidence has been hindered by difficulties in measuring exposure for the population in general and for minority populations in particular. After briefly discussing research findings on associations of common air pollutants with disease incidence, the authors summarize recent studies of radial/ethnic subgroup differences in incidence of these diseases in the US. They then present evidence of both historic and current patterns of disproportionate minority group exposure to air pollution as measured by residence in areas where ambient air quality standards are violated. The current indications of disproportionate potential exposures of minority and low-income populations to air pollutants represent the continuation of a historical trend. The evidence of linkage between disproportionate exposure to air pollution of racial/ethnic minorities and low-income groups and their higher rates of some air pollution-related diseases is largely circumstantial. Differences in disease incidence and mortality rates among racial/ethnic groups are discussed for respiratory diseases, cancers, and lead poisoning. Pollutants of concern include CO, Pb, SO{sub 2}, O{sub 3}, and particulates.

Nieves, L.A.; Wernette, D.R.

1997-02-01T23:59:59.000Z

310

Tunable, oblique incidence resonant grating filter for telecommunications  

Science Journals Connector (OSTI)

We have designed a tunable, oblique-incidence resonant grating filter that covers the C band as an add-drop device for incident TE-polarized light. We tune the filter by tilting a...

Niederer, Guido; Herzig, Hans Peter; Shamir, Joseph; Thiele, Hans; Schnieper, Marc; Zschokke, Christian

2004-01-01T23:59:59.000Z

311

EM-Led Radiological Incident Response Program Receives Honors...  

Broader source: Energy.gov (indexed) [DOE]

EM-Led Radiological Incident Response Program Receives Honors EM-Led Radiological Incident Response Program Receives Honors May 29, 2014 - 12:00pm Addthis Jessie Welch performs...

312

National Heart, Lung, and Blood Institute  

E-Print Network [OSTI]

National Heart, Lung, and Blood Institute A T - A - G L A N C E : Facts About Healthy Weight Why. The more you weigh, the more likely you are to suffer from heart disease, high blood pressure, diabetes indicator of your risk for a variety of diseases. To check your BMI, use the National Heart, Lung, and Blood

Bandettini, Peter A.

313

National Heart, Lung, and Blood Institute  

E-Print Network [OSTI]

National Heart, Lung, and Blood Institute A T - A - G L A N C E : Healthy Sleep S leep is not just on a regular basis increases the risk of high blood pressure, heart disease, and other medical conditions information on healthy sleep and sleep disorders is available from the National Heart, Lung, and Blood

Bandettini, Peter A.

314

Computerized comprehensive data analysis of Lung Imaging Database Consortium (LIDC)  

SciTech Connect (OSTI)

Purpose: Lung Image Database Consortium (LIDC) is the largest public CT image database of lung nodules. In this study, the authors present a comprehensive and the most updated analysis of this dynamically growing database under the help of a computerized tool, aiming to assist researchers to optimally use this database for lung cancer related investigations. Methods: The authors developed a computer scheme to automatically match the nodule outlines marked manually by radiologists on CT images. A large variety of characteristics regarding the annotated nodules in the database including volume, spiculation level, elongation, interobserver variability, as well as the intersection of delineated nodule voxels and overlapping ratio between the same nodules marked by different radiologists are automatically calculated and summarized. The scheme was applied to analyze all 157 examinations with complete annotation data currently available in LIDC dataset. Results: The scheme summarizes the statistical distributions of the abovementioned geometric and diagnosis features. Among the 391 nodules, (1) 365 (93.35%) have principal axis length {<=}20 mm; (2) 120, 75, 76, and 120 were marked by one, two, three, and four radiologists, respectively; and (3) 122 (32.48%) have the maximum volume overlapping ratios {>=}80% for the delineations of two radiologists, while 198 (50.64%) have the maximum volume overlapping ratios <60%. The results also showed that 72.89% of the nodules were assessed with malignancy score between 2 and 4, and only 7.93% of these nodules were considered as severely malignant (malignancy {>=}4). Conclusions: This study demonstrates that LIDC contains examinations covering a diverse distribution of nodule characteristics and it can be a useful resource to assess the performance of the nodule detection and/or segmentation schemes.

Tan Jun; Pu Jiantao; Zheng Bin; Wang Xingwei; Leader, Joseph K. [Department of Radiology, Imaging Research Division, University of Pittsburgh, 3362 Fifth Avenue, Pittsburgh, Pennsylvania 15213 (United States)

2010-07-15T23:59:59.000Z

315

Gender differences in the incidence of background and chemically induced primary pulmonary neoplasms in B6C3F1 mice: A retrospective analysis of the National Toxicology Program (NTP) carcinogenicity bioassays  

Science Journals Connector (OSTI)

Abstract The National Toxicology Program (NTP) database of technical reports on carcinogenicity bioassays has been interrogated for the incidence of primary pulmonary neoplasms in B6C3F1 mice. A total of 170 study reports were selected, from studies that completed the in-life phase during 1983–2007, which included neoplasm incidence data for 180 control groups comprising both male and female mice. The incidence (median and inter-quartile range) of males with alveolar/bronchiolar adenoma was 16% (12–20%), and for females it was 5% (2–8%); the incidence of males with alveolar/bronchiolar carcinoma was 8% (4–12%), and for females it was 2% (0–4%); and the incidence of males with combined alveolar/bronchiolar adenoma or carcinoma was 24% (18–30%), and for females it was 8% (6–12%). Comparing the incidence of animals bearing these lesions on a per study basis showed the median incidence in males to be 3.0-fold, 2.0-fold, and 2.8-fold higher than in females. The incidence of other primary pulmonary neoplasms was <10% of the alveolar/bronchiolar neoplasms. Comparison of gender-specific response to lung tumorigens showed that the increase in incidence of tumors above control levels was greater in females than in males.

Nigel P. Moore; Lisa G. McFadden; Bryce D. Landenberger; Johnson Thomas

2013-01-01T23:59:59.000Z

316

Precursors in Cancer Epidemiology: Aligning Definition and Function  

Science Journals Connector (OSTI)

...than the average using a standard precancer test; consequently...radon-associated lung cancer from uranium miners.Lancet 1992...stratification: a business plan for biomarker development...overweight and obesity using standard body mass index categories: a systematic review and meta-analysis...

Sholom Wacholder

2013-04-01T23:59:59.000Z

317

Hazardous Materials Incident Response Procedure | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Hazardous Materials Incident Response Procedure Hazardous Materials Incident Response Procedure Hazardous Materials Incident Response Procedure The purpose of this procedure is to provide guidance for developing an emergency response plan, as outlined in OSHA's 29 CFR 1910.120(q), for facility response. This model has been adopted and applied to work for response to transportation accidents involving radioactive material or other hazardous materials incidents Hazardous Materials Incident Response Procedure.docx More Documents & Publications Handling and Packaging a Potentially Radiologically Contaminated Patient Decontamination Dressdown at a Transportation Accident Involving Radioactive Material Medical Examiner/Coroner on the Handling of a Body/Human Remains that are Potentially Radiologically Contaminated

318

Evaluation of Incident Risks in a Repository for Radioactive Waste  

SciTech Connect (OSTI)

A probabilistic safety assessment of the operation phase of a repository for radioactive waste requires the knowledge of incident risks. These are evaluated from generic observations. The present method accounts for the uncertainty (1) of whether an incident occurs, (2) of the incident rate, (3) of the duration of generic observation, and (4) of the duration of operation phase of the repository. It yields a mean risk and its standard deviation from a minimum of generic data, comprising only the number of observed incidents and the duration of the observation, as more comprehensive generic data are seldom available. It was shown that incidents sharing a common generic observation must be either merged together to a total incident or the generic observation must be split up in sub-observations, one for each such incident. The method was tested on the example of the German Konrad repository for low-level waste in a deep geological formation. (authors)

Grundler, D.; Mariae, D.; Muller, W.; Boetsch, W. [Institut fur Sicherheitstechnologie (ISTec), Koln (Germany); Thiel, J. [Bundesamt fur Strahlenschutz (BfS), Salzgitter (Germany)

2008-07-01T23:59:59.000Z

319

The Impact of Heart Irradiation on Dose-Volume Effects in the Rat Lung  

SciTech Connect (OSTI)

Purpose: To test the hypothesis that heart irradiation increases the risk of a symptomatic radiation-induced loss of lung function (SRILF) and that this can be well-described as a modulation of the functional reserve of the lung. Methods and Materials: Rats were irradiated with 150-MeV protons. Dose-response curves were obtained for a significant increase in breathing frequency after irradiation of 100%, 75%, 50%, or 25% of the total lung volume, either including or excluding the heart from the irradiation field. A significant increase in the mean respiratory rate after 6-12 weeks compared with 0-4 weeks was defined as SRILF, based on biweekly measurements of the respiratory rate. The critical volume (CV) model was used to describe the risk of SRILF. Fits were done using a maximum likelihood method. Consistency between model and data was tested using a previously developed goodness-of-fit test. Results: The CV model could be fitted consistently to the data for lung irradiation only. However, this fitted model failed to predict the data that also included heart irradiation. Even refitting the model to all data resulted in a significant difference between model and data. These results imply that, although the CV model describes the risk of SRILF when the heart is spared, the model needs to be modified to account for the impact of dose to the heart on the risk of SRILF. Finally, a modified CV model is described that is consistent to all data. Conclusions: The detrimental effect of dose to the heart on the incidence of SRILF can be described by a dose dependent decrease in functional reserve of the lung.

Luijk, Peter van [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands)], E-mail: p.van.luijk@rt.umcg.nl; Faber, Hette [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands); Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Meertens, Harm [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands); Schippers, Jacobus M. [Accelerator Department, Paul Scherrer Institut, Villigen, Switerland (Switzerland); Langendijk, Johannes A. [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands); Brandenburg, Sytze [Kernfysisch Versneller Instituut, University of Groningen, Groningen (Netherlands); Kampinga, Harm H. [Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Coppes, Robert P. Ph.D. [Department of Radiation Oncology, University Medical Center, Groningen (Netherlands); Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)

2007-10-01T23:59:59.000Z

320

Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells  

SciTech Connect (OSTI)

Chronic arsenic exposure remains a human health risk; however a clear mode of action to understand gene signaling-driven arsenic carcinogenesis is currently lacking. This study chronically exposed human lung epithelial BEAS-2B cells to low-dose arsenic trioxide to elucidate cancer promoting gene signaling networks associated with arsenic-transformed (B-As) cells. Following a 6 month exposure, exposed cells were assessed for enhanced cell proliferation, colony formation, invasion ability and in vivo tumor formation compared to control cell lines. Collected mRNA was subjected to whole genome expression microarray profiling followed by in silico Ingenuity Pathway Analysis (IPA) to identify lung carcinogenesis modes of action. B-As cells displayed significant increases in proliferation, colony formation and invasion ability compared to BEAS-2B cells. B-As injections into nude mice resulted in development of primary and secondary metastatic tumors. Arsenic exposure resulted in widespread up-regulation of genes associated with mitochondrial metabolism and increased reactive oxygen species protection suggesting mitochondrial dysfunction. Carcinogenic initiation via reactive oxygen species and epigenetic mechanisms was further supported by altered DNA repair, histone, and ROS-sensitive signaling. NF-?B, MAPK and NCOR1 signaling disrupted PPAR?/?-mediated lipid homeostasis. A ‘pro-cancer’ gene signaling network identified increased survival, proliferation, inflammation, metabolism, anti-apoptosis and mobility signaling. IPA-ranked signaling networks identified altered p21, EF1?, Akt, MAPK, and NF-?B signaling networks promoting genetic disorder, altered cell cycle, cancer and changes in nucleic acid and energy metabolism. In conclusion, transformed B-As cells with their whole genome expression profile provide an in vitro arsenic model for future lung cancer signaling research and data for chronic arsenic exposure risk assessment. Highlights: ? Chronic As{sub 2}O{sub 3} exposure to lung epithelial cells resulted in a cancer-like phenotype. ? Mice injected with arsenic transformed (B-As) cells displayed metastatic tumors. ? Microarray profiling revealed changes in mitochondrial metabolism and ROS response. ? p21, EF1?, Akt, MAPK, PPAR? and NF-?B networks promoted pro-cancer signaling. ? B-As cells represent a lung cancer model to explore As-associated carcinogenesis.

Stueckle, Todd A., E-mail: tstueckle@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Lu, Yongju, E-mail: yongju6@hotmail.com [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Davis, Mary E., E-mail: mdavis@wvu.edu [Department of Physiology, West Virginia University, Morgantown, WV 26506 (United States); Wang, Liying, E-mail: lmw6@cdc.gov [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States)] [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Jiang, Bing-Hua, E-mail: bhjiang@jefferson.edu [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States)] [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Holaskova, Ida, E-mail: iholaskova@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Schafer, Rosana, E-mail: rschafer@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Barnett, John B., E-mail: jbarnett@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Rojanasakul, Yon, E-mail: yrojan@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)

2012-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Effects of Cruciferous Vegetable Consumption on Urinary Metabolites of the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Singapore Chinese  

Science Journals Connector (OSTI)

...chromatography purification, and quantitation by gas chromatography with nitrosamine selective...vegetables, and lung cancer risk in women: the Missouri womens health study (United States...and on methods of analysis in respect of oil seeds. Official Journal of the European...

Stephen S. Hecht; Steven G. Carmella; Patrick M.J. Kenney; Siew-Hong Low; Kazuko Arakawa; and Mimi C. Yu

2004-06-01T23:59:59.000Z

322

Marine Sponge Cribrochalina vasculum Compounds Activate Intrinsic Apoptotic Signaling and Inhibit Growth Factor Signaling Cascades in Non–Small Cell Lung Carcinoma  

Science Journals Connector (OSTI)

...magnification scale bar, 15 mum). Blue, DAPI staining of nucleus; green, cytochrome c. C, NSCLC U-1810 cells or diploid fibroblasts...analysis identifies JNK signaling as critical for high linear energy transfer radiation-induced apoptosis in non-small lung cancer...

Ana Zovko; Kristina Viktorsson; Petra Hååg; Dimitry Kovalerchick; Katarina Färnegårdh; Andrea Alimonti; Micha Ilan; Shmuel Carmeli; and Rolf Lewensohn

2014-12-01T23:59:59.000Z

323

Updated fracture incidence rates for the US version of FRAX®  

E-Print Network [OSTI]

presenting with non-vertebral fractures. Osteoporos Int 18:2006) Epidemiology of vertebral fractures: implications forORIGINAL ARTICLE Updated fracture incidence rates for the US

Ettinger, B.; Black, D. M.; Dawson-Hughes, B.; Pressman, A. R.; Melton, L. J.

2010-01-01T23:59:59.000Z

324

Model Recovery Procedure for Response to a Radiological Transportation Incident  

Broader source: Energy.gov [DOE]

This Transportation Emergency Preparedness Program (TEPP) Model Recovery Procedure contains the recommended elements for developing and conducting recovery planning at transportation incident scene...

325

E-Print Network 3.0 - awaiting lung transplantation Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

www.nejm.org november 22, 2007 2143 Summary: of patients with cystic fibrosis awaiting heart and lung transplantation. J Heart Lung Transplant 1993... original article Lung...

326

Use of incident databases for cause and consequence analysis and national estimates  

E-Print Network [OSTI]

stored in existing databases can lead to useful conclusions and reduction of chemical incidents and consequences of incidents. An incident database is a knowledge based system that can give an insight to the situation which led to an incident. Effective...

Obidullah, A.S.M.

2007-04-25T23:59:59.000Z

327

Cancer risk estimation in Belarussian children due to thyroid irradiation as a consequence of the Chernobyl nuclear accident  

SciTech Connect (OSTI)

The thyroid doses received by the juvenile population of Belarus following the Chernobyl accident ranged up to about 10 Gy. The thyroid cancer risk estimate recommended in NCRP Report No. 80 was used to predict the number of thyroid cancer cases among children during 1990-1992 in selected Belarussian regions and cities. The results obtained using this risk estimate show an excess of thyroid cancer cases being registered vs. the predicted cases. Thyroid cancer incidence rate among boys under investigation is higher than among girls in the postaccident period. The excess of the observed over the expected incidence in the general juvenile population is caused by the high thyroid cancer incidence rate among boys. These results, which can be considered part of the first stage of a thorough thyroid cancer risk estimation after the Chernobyl accident, demonstrate the critical need to complete these studies in depth. 6 refs., 5 figs., 3 tabs.

Buglova, E.; Kenigsberg, J.E.; Sergeeva, N.V. [Research Inst. of Radiation Medicine, Minsk (Belarus)

1996-07-01T23:59:59.000Z

328

CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM  

E-Print Network [OSTI]

CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM 2010 ANNUAL REPORT WITH STATISTICAL DATA FROM 2009 UNIVERSITY OF ILLINOIS MEDICAL CENTER #12;2 CANCER PROGRAM ANNUAL REPORT 2 #12;3 CANCER PROGRAM ANNUAL REPORT 3 UIMC CANCER PROGRAM CHANGING MULTIDISCIPLINARY CARE. FOR GOOD. #12;4 CANCER PROGRAM ANNUAL REPORT

Illinois at Chicago, University of

329

Incident involving UCSD student(s) takes place. UCSD STUDENT  

E-Print Network [OSTI]

Incident involving UCSD student(s) takes place. UCSD STUDENT CONDUCT PROCESS for individual students (updated 9/20/11) The Office of Student Conduct receives an incident report (i.e. RA, RSO, UCSD Police, student/faculty/staff complaint, etc). If sufficient evidence is present to support a violation

Russell, Lynn

330

On using an adaptive neural network to predict lung tumor motion during respiration for radiotherapy applications  

SciTech Connect (OSTI)

In this study we address the problem of predicting the position of a moving lung tumor during respiration on the basis of external breathing signals--a technique used for beam gating, tracking, and other dynamic motion management techniques in radiation therapy. We demonstrate the use of neural network filters to correlate tumor position with external surrogate markers while simultaneously predicting the motion ahead in time, for situations in which neither the breathing pattern nor the correlation between moving anatomical elements is constant in time. One pancreatic cancer patient and two lung cancer patients with mid/upper lobe tumors were fluoroscopically imaged to observe tumor motion synchronously with the movement of external chest markers during free breathing. The external marker position was provided as input to a feed-forward neural network that correlated the marker and tumor movement to predict the tumor position up to 800 ms in advance. The predicted tumor position was compared to its observed position to establish the accuracy with which the filter could dynamically track tumor motion under nonstationary conditions. These results were compared to simplified linear versions of the filter. The two lung cancer patients exhibited complex respiratory behavior in which the correlation between surrogate marker and tumor position changed with each cycle of breathing. By automatically and continuously adjusting its parameters to the observations, the neural network achieved better tracking accuracy than the fixed and adaptive linear filters. Variability and instability in human respiration complicate the task of predicting tumor position from surrogate breathing signals. Our results show that adaptive signal-processing filters can provide more accurate tumor position estimates than simpler stationary filters when presented with nonstationary breathing motion.

Isaksson, Marcus; Jalden, Joakim; Murphy, Martin J. [Department of Electrical Engineering, Stanford University, Stanford, California 94036 (United States); Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 (United States)

2005-12-15T23:59:59.000Z

331

Abstract 2006: The role of neuronal predominant gene expression in breast cancer brain metastasis  

Science Journals Connector (OSTI)

...predominant gene expression in breast cancer brain metastasis Deepak P. Kanojia Purva Sarvaiya...Chicago, Chicago, IL. Breast cancer brain metastasis (BCBM) occur in about 10-30...the highest incidence of metastasis to brain, mechanism of which is poorly understood...

Deepak P. Kanojia; Purva Sarvaiya; Jian Qiao; Lingjiao Zhang; Irina Balyasnikova; Maciej S. Lesniak

2014-10-01T23:59:59.000Z

332

A framework for identification of actionable cancer genome dependencies in small cell lung cancer  

Science Journals Connector (OSTI)

...by the German Ministry of Science and Education as part of the National Network...Bayesian inference in MrBayes, with poster probabilities...Alignment and Evolutionary Analysis. Science 320:1632-1635. Python genome...

Martin L. Sos; Felix Dietlein; Martin Peifer; Jakob Schöttle; Hyatt Balke-Want; Christian Müller; Mirjam Koker; André Richters; Stefanie Heynck; Florian Malchers; Johannes M. Heuckmann; Danila Seidel; Patrick A. Eyers; Roland T. Ullrich; Andrey P. Antonchick; Viktor V. Vintonyak; Peter M. Schneider; Takashi Ninomiya; Herbert Waldmann; Reinhard Büttner; Daniel Rauh; Lukas C. Heukamp; Roman K. Thomas

2012-01-01T23:59:59.000Z

333

Expression and Functional Analyses of Breast Cancer Resistance Protein in Lung Cancer  

Science Journals Connector (OSTI)

...SN-38-resistant PC-6/SN2-5 cells were selected from...previously (18) . PC-6/SN2-5 cells overexpressed the...Roche Diagnostics). The reaction condition was 40 cycles with...compared with that of PC-6/SN2-5 cells overexpressing BCRP...

Shigeru Kawabata; Mikio Oka; Hiroshi Soda; Ken Shiozawa; Katsumi Nakatomi; Junji Tsurutani; Yoichi Nakamura; Seiji Doi; Takeshi Kitazaki; Kazuyuki Sugahara; Yasuaki Yamada; Shimeru Kamihira; and Shigeru Kohno

2003-08-01T23:59:59.000Z

334

A Novel Markerless Technique to Evaluate Daily Lung Tumor Motion Based on Conventional Cone-Beam CT Projection Data  

SciTech Connect (OSTI)

Purpose: In this study, we present a novel markerless technique, based on cone beam computed tomography (CBCT) raw projection data, to evaluate lung tumor daily motion. Method and Materials: The markerless technique, which uses raw CBCT projection data and locates tumors directly on every projection, consists of three steps. First, the tumor contour on the planning CT is used to create digitally reconstructed radiographs (DRRs) at every projection angle. Two sets of DRRs are created: one showing only the tumor, and another with the complete anatomy without the tumor. Second, a rigid two-dimensional image registration is performed to register the DRR set without the tumor to the CBCT projections. After the registration, the projections are subtracted from the DRRs, resulting in a projection dataset containing primarily tumor. Finally, a second registration is performed between the subtracted projection and tumor-only DRR. The methodology was evaluated using a chest phantom containing a moving tumor, and retrospectively in 4 lung cancer patients treated by stereotactic body radiation therapy. Tumors detected on projection images were compared with those from three-dimensional (3D) and four-dimensional (4D) CBCT reconstruction results. Results: Results in both static and moving phantoms demonstrate that the accuracy is within 1 mm. The subsequent application to 22 sets of CBCT scan raw projection data of 4 lung cancer patients includes about 11,000 projections, with the detected tumor locations consistent with 3D and 4D CBCT reconstruction results. This technique reveals detailed lung tumor motion and provides additional information than conventional 4D images. Conclusion: This technique is capable of accurately characterizing lung tumor motion on a daily basis based on a conventional CBCT scan. It provides daily verification of the tumor motion to ensure that these motions are within prior estimation and covered by the treatment planning volume.

Yang Yin; Zhong Zichun; Guo Xiaohu [Department of Computer Science, University of Texas at Dallas, Richardson, TX (United States); Wang Jing; Anderson, John; Solberg, Timothy [Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 (United States); Mao Weihua, E-mail: weihua.mao@utsouthwestern.edu [Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 (United States)

2012-04-01T23:59:59.000Z

335

The Department's Cyber Security Incident Management Program, IG-0787 |  

Broader source: Energy.gov (indexed) [DOE]

Cyber Security Incident Management Program, Cyber Security Incident Management Program, IG-0787 The Department's Cyber Security Incident Management Program, IG-0787 The Department of Energy operates numerous interconnected computer networks and systems to help accon~plishit s strategic missions in the areas of energy, defense, science, and the environment. These systems are frequently subjected to sophisticated cyber attacks that could potentially affect the Department's ability to carry out its mission. During Fiscal Year 2006, the Department experienced 132 incidents of sufficient severity to require reporting to law enforcement, an increase of 22 percent over the prior year. These statistics, troubling as they may be, are not unique to the Department; they are, in fact, reflective of a trend in cyber attacks throughout the government.

336

Personnel Accountability for Non-COOP Incidents | Department...  

Broader source: Energy.gov (indexed) [DOE]

Accountability for Non-COOP Incidents Responsible Contacts Bruce Murray HR Policy Advisor E-mail bruce.murray@hq.doe.gov Phone 202-586-3372 More Documents & Publications...

337

A probabilistic safety analysis of incidents in nuclear research reactors  

Science Journals Connector (OSTI)

......System for Research Reactor (IRSRR). Available...System for Research Reactor (IRSRR). Available...76. 7 Manual on reliability data collection for research reactor PSAs. (1992) IAEA...probabilistic safety analysis of incidents in nuclear......

Valdir Maciel Lopes; Gian Maria Agostinho Angelo Sordi; Mauricio Moralles; Tufic Madi Filho

2012-06-01T23:59:59.000Z

338

Frequent Antibiotic Use and Second Breast Cancer Events  

Science Journals Connector (OSTI)

...were obtained from health plan administrative databases and medical record review. Frequent antibiotic...SEER was the gold standard for incident breast cancer...were from a single health plan, which may not represent...being enrolled in a health plan mitigates disparities...

Heidi S. Wirtz; Diana S.M. Buist; Julie R. Gralow; William E. Barlow; Shelly Gray; Jessica Chubak; Onchee Yu; Erin J.A. Bowles; Monica Fujii; and Denise M. Boudreau

2013-09-01T23:59:59.000Z

339

Is Cadmium a Cause of Human Pancreatic Cancer?  

Science Journals Connector (OSTI)

...g., in nickel-cadmium batteries and electroplating, as a component...cadmium are the burning of fossil fuels and waste materials and the...proteinurea. The health of battery workers exposed to cadmium...cancer incidence in Swedish battery workers exposed to cadmium...

Gary G. Schwartz and Isildinha M. Reis

2000-02-01T23:59:59.000Z

340

National Heart, Lung, and Blood Institute  

E-Print Network [OSTI]

National Heart, Lung, and Blood Institute A T - A - G L A N C E : Lowering Your Blood Pressure foods that are heart healthy and low in salt and sodium. High blood pressure, which is blood pressure is dangerous because it makes your heart work too hard, hardens the walls of your arteries, and can cause

Bandettini, Peter A.

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

National Heart, Lung, and Blood Institute  

E-Print Network [OSTI]

problems, including heart attack, stroke, or even death. Overview Atherosclerosis can affect any artery-rich blood to your heart. CHD can lead to angina (chest pain) and heart attack. CHD is the leading causeNational Heart, Lung, and Blood Institute A T - A - G L A N C E : Atherosclerosis A therosclerosis

Bandettini, Peter A.

342

National Heart, Lung, and Blood Institute  

E-Print Network [OSTI]

National Heart, Lung, and Blood Institute A T - A - G L A N C E : Physical Activity and Your Heart, is that even modest amounts of physi- cal activity are good for your health, especially your heart health activity is the type of physical activity that benefits your heart the most. This type of activity moves

Bandettini, Peter A.

343

National Heart, Lung, and Blood Institute  

E-Print Network [OSTI]

National Heart, Lung, and Blood Institute A T - A - G L A N C E : What You Need To Know About High- tors for heart disease. In fact, the higher your blood cholesterol, the greater your risk of developing heart disease or having a heart attack. Heart disease is the #1 killer of men and women in the United

Bandettini, Peter A.

344

National Heart, Lung, and Blood Institute  

E-Print Network [OSTI]

National Heart, Lung, and Blood Institute A T - A - G L A N C E : Coronary Heart Disease C oronary heart disease (CHD), also called coronary artery disease, is the leading cause of death in the United. These arteries supply your heart muscle with oxygen-rich blood. Plaque is made up of fat, cholesterol, calcium

Bandettini, Peter A.

345

Guiding Aerosol Deposition in the Lung  

Science Journals Connector (OSTI)

...desired. Successful application of this idea in practice in humans would be an advance; for the present, the idea is more like a magnetic field: it is invisible, but you can feel its pull. A model of targeted drug delivery to the lung uses magnetized droplets and a magnetic field.

Coates A.L.

2008-01-17T23:59:59.000Z

346

Cancer Risk among Children Born after Assisted Conception  

Science Journals Connector (OSTI)

...of 26,692 children born after assisted conception in Sweden between 1982 and 2005. A total of 47 cancers (excluding histiocytosis) were observed in this cohort, which had a higher risk of childhood cancer than did children conceived without assisted conception during the same period (odds ratio after... In a large study using registry data from Britain, overall cancer incidence was not increased among children born after assisted conception. Assisted conception was associated with an increased risk of hepatoblastoma and rhabdomyosarcoma, but the absolute risks were small.

Williams C.L.; Bunch K.J.; Stiller C.A.

2013-11-07T23:59:59.000Z

347

SP 800-61 Rev. 1. Computer Security Incident Handling Guide  

Science Journals Connector (OSTI)

Computer security incident response has become an important component of information technology (IT) programs. Security-related threats have become not only more numerous and diverse but also more damaging and disruptive. An incident response capability ... Keywords: Computer security incident, incident handling, incident response, threats, vulnerabilities

Karen A. Scarfone; Timothy Grance; Kelly Masone

2008-03-01T23:59:59.000Z

348

Breaking a Pocket of Resistance in the Fight Against Cancer  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Breaking a Pocket of Resistance in Breaking a Pocket of Resistance in the Fight Against Cancer Breaking a Pocket of Resistance in the Fight Against Cancer Print Thursday, 12 December 2013 11:55 ras protein The new class of inhibitors interacts with a specific mutation (Glycine to Cysteine) associated with a number of types of lung cancer. Mutations in the protein K-RAS are a very common cause for certain types of human cancers and are generally associated with a poor response to standard therapies. RAS, an abbreviation of Rat Sarcoma, is a nucleotide binding protein that responds to chemical signals (nucleotides). When in the "on" state, RAS activates other proteins, resulting in a cascade of biochemical processes; in the "off" state, RAS remains inactive. Mutations in the RAS

349

Nested methylation-specific polymerase chain reaction cancer detection method  

DOE Patents [OSTI]

A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

2007-05-08T23:59:59.000Z

350

U.S. Geographic Distribution of Prevaccine Era Cervical Cancer Screening, Incidence, Stage, and Mortality  

Science Journals Connector (OSTI)

...the central Mississippi Valley (including Missouri, Kentucky, and Tennessee), West North Central states (spanning...the lower Mississippi Valley, along the Texas-Mexico...areas such as parts of the West North Central and Mountain...

Marie-Josèphe Horner; Sean F. Altekruse; Zhaohui Zou; Louise Wideroff; Hormuzd A. Katki; and David G. Stinchcomb

2011-04-01T23:59:59.000Z

351

Milk consumption and incidence rates of prostate, breast, and colorectal cancers: An ecologic study  

Science Journals Connector (OSTI)

...vegetable, and alcohol consumption in nine time periods...Organization. Cigarette consumption data (cigarettes...were derived from World Health Organization...fat, and alcohol consumption was expressed in percent of energy (% E) and vegetable...

Jianjun Zhang and Hugo Kesteloot

2005-05-01T23:59:59.000Z

352

Eye Cancer Incidence in U.S. States and Access to Fluoridated Water  

Science Journals Connector (OSTI)

...S. States and Access to Fluoridated Water Gary G. Schwartz 1 2 * * Corresponding...of the population receiving fluoridated water; that is, higher rates were found in...inversely with the availability of fluoridated water. Materials and Methods Uveal melanoma...

Gary G. Schwartz

2014-09-01T23:59:59.000Z

353

Socioeconomic status and prostate cancer incidence and mortality rates among the diverse population of California  

E-Print Network [OSTI]

Palo Alto, CA 94301, USA Hispanic Whites, Hispanics, and Asian/Paci?c Islanders, we conducted a large population-

2009-01-01T23:59:59.000Z

354

NON-INVASIVE OPTICAL DETECTION OF EPITHELIAL CANCER USING OBLIQUE INCIDENCE DIFFUSE REFLECTANCE SPECTROSCOPY  

E-Print Network [OSTI]

-pigmented lesions...................... 50 25 Results of the testing dataset for the non-pigmented lesions ..................... 51 26 Absorption coefficient spectra of common nevi, dysplastic nevi and melanoma... of abnormal cells that can only be seen by 5 histologic analysis and not through the endoscope. The current recommendation for patients who have a stable diagnosis of negative for dysplasia, confirmed by two endoscopic biopsy surveillance procedures...

Garcia-Uribe, Alejandro

2010-01-16T23:59:59.000Z

355

Solid cancer incidence among the Chernobyl emergency workers residing in Russia: estimation of radiation risks  

Science Journals Connector (OSTI)

For the method of radiation dose measurement, the dosimetric data for the studied... 1. Exposure or absorbed dose recorded...

V. K. Ivanov; A. I. Gorski; A. F. Tsyb…

2004-05-01T23:59:59.000Z

356

Increase in Incidence of Colorectal Cancer Among Young Men and Women in the United States  

Science Journals Connector (OSTI)

...27). The average energy intake from hamburgers...decline in alcohol consumption in the United...Wolk A. Meat consumption and risk of colorectal...prepared away from home in the American...of fast-food consumption on energy intake and diet...

Rebecca L. Siegel; Ahmedin Jemal; and Elizabeth M. Ward

2009-06-01T23:59:59.000Z

357

Incident Invasive Breast Cancer, Geographic Location of Residence, and Reported Average Time Spent Outside  

Science Journals Connector (OSTI)

...areas of low versus high solar irradiance measured in...residence and geographic solar irradiance are not consistently...total average sunlight energy striking the ground...foods and supplements (energy adjusted IU/d). Some...low compared with high solar irradiance (comparing...

Amy E. Millen; Mary Pettinger; Jo L. Freudenheim; Robert D. Langer; Carol A. Rosenberg; Yasmin Mossavar-Rahmani; Christine M. Duffy; Dorothy S. Lane; Anne McTiernan; Lewis H. Kuller; Ana Maria Lopez; and Jean Wactawski-Wende

2009-02-01T23:59:59.000Z

358

The Clinical and Economic Burden of a Sustained Increase in Thyroid Cancer Incidence  

Science Journals Connector (OSTI)

...Funded Research Portfolio Website. [cited 2012 Aug 6...gov/nciportfolio/search/funded?action=fulltype...Epidemiology and End Results Website. [cited 2012 Aug 6...Chou FF, Liu RT, Tung SC, Chen JF, Kuo MC...States Census Bureau Website. [cited 2012 Aug 6...

Briseis Aschebrook-Kilfoy; Rebecca B. Schechter; Ya-Chen Tina Shih; Edwin L. Kaplan; Brian C.-H. Chiu; Peter Angelos; and Raymon H. Grogan

2013-07-01T23:59:59.000Z

359

Thyroid Cancer Incidence among Active Duty U.S. Military Personnel, 1990–2004  

Science Journals Connector (OSTI)

...1901 The use of heavy metals like depleted uranium (DU) and tungsten alloy (WA...metal shrapnel. The long-term health effects, including carcinogenic...fragments will affect the long-term health of offspring conceived by these...

Lindsey R. Enewold; Jing Zhou; Susan S. Devesa; Amy Berrington de Gonzalez; William F. Anderson; Shelia H. Zahm; Alexander Stojadinovic; George E. Peoples; Aizenhawar J. Marrogi; John F. Potter; Katherine A. McGlynn; and Kangmin Zhu

2011-11-01T23:59:59.000Z

360

Cancer Incidence in the U.S. Military Population: Comparison with Rates from the SEER Program  

Science Journals Connector (OSTI)

...132-8. 26. The Royal Society. The health hazards of depleted uranium munitions. Part I. London, UK: The...http://royalsociety.org/The-health-hazards-of-depleted-uranium-munitions-Part-1-Full-Report...

Kangmin Zhu; Susan S. Devesa; Hongyu Wu; Shelia Hoar Zahm; Ismail Jatoi; William F. Anderson; George E. Peoples; Larry G. Maxwell; Elder Granger; John F. Potter; and Katherine A. McGlynn

2009-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

A Web Tool for Age–Period–Cohort Analysis of Cancer Incidence and Mortality Rates  

Science Journals Connector (OSTI)

...estimable APC functions and corresponding Wald tests in R code that can be accessed through...with associated statistical hypothesis tests. In this report, we summarize the Web...in Fig. 2. A number of key hypothesis tests are also provided in the Wald Tests tab...

Philip S. Rosenberg; David P. Check; William F. Anderson

2014-11-01T23:59:59.000Z

362

A Prospective Study of Physical Activity and Breast Cancer Incidence in African-American Women  

Science Journals Connector (OSTI)

...factors. They are followed every 2 years through mailed and web questionnaires that update exposure information and ascertain...Russell CW , Boggs DA, Palmer JR, Rosenberg L.Use of a web-based questionnaire in the Black Women's Health Study.Am...

Lynn Rosenberg; Julie R. Palmer; Traci N. Bethea; Yulun Ban; Kristen Kipping-Ruane; Lucile L. Adams-Campbell

2014-11-01T23:59:59.000Z

363

Breast Cancer Incidence Patterns among California Hispanic Women: Differences by Nativity and Residence in an Enclave  

Science Journals Connector (OSTI)

...as Caucasian, non-Hispanic, Hispanic, African American and...stratified by median household income. Models were...at diagnosis, median household income, total number...Caucasian, non-Hispanic, 3.5% Hispanic...

Theresa H.M. Keegan; Esther M. John; Kari M. Fish; Theresa Alfaro-Velcamp; Christina A. Clarke; and Scarlett L. Gomez

2010-05-01T23:59:59.000Z

364

Gastric Cancer Incidence among Hispanics in California: Patterns by Time, Nativity, and Neighborhood Characteristics  

Science Journals Connector (OSTI)

...The sample consisted of 40.3% Hispanic, 33.3% non-Hispanic African American and 26.4% non-Hispanic white women. Maternal education...participants own education, occupation, household income, race/ethnicity, and body...

Ellen T. Chang; Scarlett Lin Gomez; Kari Fish; Clayton W. Schupp; Julie Parsonnet; Mindy C. DeRouen; Theresa H. M. Keegan; Christina A. Clarke; and Sally L. Glaser

2012-05-01T23:59:59.000Z

365

Prospective Studies of Body Mass Index with Head and Neck Cancer Incidence and Mortality  

Science Journals Connector (OSTI)

...completed prior to and at RT completion, and skin toxicity was assessed at week 3 and RT completion. We recorded patient demographics, body mass index (BMI), disease and treatment...50 Gy 10 Gy boost. At RT completion, all patients had ST...

Mia M. Gaudet; Alpa V. Patel; Juzhong Sun; Janet S. Hildebrand; Marjorie L. McCullough; Amy Y. Chen; and Susan M. Gapstur

2012-03-01T23:59:59.000Z

366

A comprehensive analysis of natural gas distribution pipeline incidents  

Science Journals Connector (OSTI)

The objective of this paper is to provide a reference database for pipeline companies and/or regulators with an investigation of safety performance of US natural gas distribution pipelines. With a total of 3,679 natural gas distribution pipeline incidents between 1985 and 2010, nine safety indicators are statistically analysed in terms of the year, pipeline length, regions, pipeline diameter, pipeline wall thickness, material, age, incident area and incident cause to identify the relationship between safety indicators and various variables. Overall average frequencies of incidents, injuries and fatalities between 1985 and 2009 are 0.0846/1,000 mile-years, 0.0407/1,000 mile-years, and 0.0094/1,000 mile-years respectively. The analysis shows that the safety performance of US natural gas distribution pipeline is improving over time, and different variables have different impact on safety performances. However, the number of annual incidents does not show a significant decline due to increasing energy demand. [Received: March 21 2012; Accepted: July 15 2012

Zhenhua Rui; Xiaoqing Wang

2013-01-01T23:59:59.000Z

367

Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the EPIC-Norfolk study  

E-Print Network [OSTI]

of breast cancer, but only a limited range of phytoestrogens has been examined in prospective cohort studies. Methods Serum and urine samples from 237 incident breast cancer cases and 952 control individuals (aged 45 to 75 years) in the European Prospective...

Ward, Heather A; Chapelais, Gaelle; Kuhnle, Gunter G C; Luben, Robert; Khaw, Kay-Tee; Bingham, Sheila

2008-04-17T23:59:59.000Z

368

2014 Headquarters Facilities Master Security Plan- Chapter 11, Incidents of Security Concern  

Broader source: Energy.gov [DOE]

2014 Headquarters Facilities Master Security Plan - Chapter 11, Incidents of Security Concern Describes DOE Headquarters procedures for reporting, investigating, and correcting Incidents of Security Concern.

369

E-Print Network 3.0 - action real-time grazing-incidence Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

operation... ) 12;Grazing Incidence Pumping (GRIP) Target optimum gain region On-axis x-ray laser Preformed plasma1... ps Grazing Incidence Pumping ... Source: Wang, Wei Hua -...

370

Josephine Ford Cancer Center Cancer Research Programs  

E-Print Network [OSTI]

Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

Berdichevsky, Victor

371

ORISE: REAC/TS Radiological Incident Medical Consultation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiological Incident Medical Consultation Radiological Incident Medical Consultation Radiological Incident Medical Consultation The Oak Ridge Institute for Science and Education (ORISE) provides the U.S. Department of Energy (DOE) with a comprehensive capability to respond effectively to medical emergencies involving radiological or nuclear materials. Through the management of the Radiation Emergency Assistance Center/Training Site (REAC/TS), ORISE provides advice and consultation to emergency personnel responsible for the medical management of radiation accidents. REAC/TS strengthens hospital preparedness for radiation emergencies by preparing and educating first responders, medical personnel and occupational health professionals who will provide care to patients with a radiation injury or illness. REAC/TS staff provide medical advice,

372

Nuclear accident and incident public affairs (pa) guidance  

SciTech Connect (OSTI)

This Directive reissues reference (a) DoD Directive 5230.16 to update DoD policy, responsibilities, and procedures for the prompt release of information to the public in the interest of public safety, and to prevent public alarm in the event of accidents or significant incidents involving nuclear weapons or nuclear components, radioactive material, nuclear weapon launch or transport vehicles (when a nuclear weapon is aboard), or nuclear reactors under DoD control. It updates DoD policy, responsibilities, and procedures during an improvised nuclear device (IND) incident.

Not Available

1993-12-20T23:59:59.000Z

373

UCSC cancer genomics browser.  

Science Journals Connector (OSTI)

...Chicago, IL Abstract 5087: UCSC Cancer Genomics Browser 2.0 Jingchun Zhu 1 Brian Craft...and analyze that data. The UCSC Cancer Genomics Browser (https://genome-cancer...enhances the interpretability of the cancer genomics information. UCSC Cancer Genomics Browser...

J Zhu; JZ Sanborn; T Wang; F Hsu; S Benz; C Szeto; L Esserman; D Haussler

2009-01-15T23:59:59.000Z

374

Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study  

Science Journals Connector (OSTI)

...human cancers, including breast, lung, brain, liver, colon, prostate, ovarian cancers...indicated in parentheses in the column heads. The last column contains P values for...rate in behavior genetics research.Behav Brain Res 2001;125:279-84. 24. Kaufman...

Paola Muti; Andrea Sacconi; Ahmed Hossain; Sara Donzelli; Noa Bossel Ben Moshe; Federica Ganci; Sabina Sieri; Vittorio Krogh; Franco Berrino; Francesca Biagioni; Sabrina Strano; Joseph Beyene; Yosef Yarden; Giovanni Blandino

2014-11-01T23:59:59.000Z

375

Method and apparatus for measuring lung density by Compton backscattering  

DOE Patents [OSTI]

The density of the lung of a patient suffering from pulmonary edema is monitored by irradiating the lung by a single collimated beam of monochromatic photons and measuring the energies of photons compton back-scattered from the lung by a single high-resolution, high-purity germanium detector. A compact system geometry and a unique data extraction scheme are utilized to minimize systematic errors due to the presence of the chestwall and multiple scattering. 11 figs., 1 tab.

Loo, B.W.; Goulding, F.S.

1988-03-11T23:59:59.000Z

376

1 888 939 3333 | cancer.ca Cancer Statistics  

E-Print Network [OSTI]

1 888 939 3333 | cancer.ca Canadian Cancer Statistics 2013 Special topic: Liver cancer Produced by Canadian Cancer Society, Statistics Canada, Public Health Agency of Canada, Provincial/Territorial Cancer Registries cancer.ca/statistics #12;2Canadian Cancer Society n Canadian Cancer Statistics 2013 Citation

Habib, Ayman

377

Violation of Laws, Losses, and Incidents of Security Concerns  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

To set forth Department of Energy (DOE) procedures to assure timely and effective action relating to violations of criminal, laws, loses, and incidents of security concern to DOE. Cancels DOE O 5631.5. Canceled by DOE O 470.1 of 9-28-1995.

1992-09-15T23:59:59.000Z

378

Bifurcation analysis of an epidemic model with nonlinear incidence  

Science Journals Connector (OSTI)

In this paper, we consider an epidemic model with the nonlinear incidence of a sigmoidal function. By mathematical analysis, it is shown that the model exhibits the bistability and undergoes the Hopf bifurcation and the Bogdanov-Takens bifurcation. By ... Keywords: Bistability, Homoclinic, Limit cycle, Sensitive, Sigmoidal

Guihua Li, Wendi Wang

2009-08-01T23:59:59.000Z

379

Recent Developments in Field Response for Mitigation of Radiological Incidents  

Broader source: Energy.gov [DOE]

Recent Developments in Field Response for Mitigation of Radiological Incidents Carlos Corredor*, Department of Energy ; Charley Yu, Argonne National Labs Abstract: Since September 11, 2001, there has been a large effort by the government to develop new methods to reduce the consequence of potential radiological incidents. This is evident in the enhancement of technologies and methods to detect, prepare, or manage radiological incidents or accidents . With any radiological accident, radiological dispersal device (RDD), or improvised nuclear device (IND) , the major focus is always on the immediate phase of an incident or accident and less centered on the intermediate phase and the late recovery phase of that incident. In support of the 2008 protective action guides(PAGs) for RDDs , established by the Department of Homeland Security and by agreement with the EPA, the White House requested establishment of a series of operational guidelines that would focus on efforts during all phases of the incident and not just the immediate phase. “Operational Guidelines” were developed for this purpose. The operational guidelines are dose based pre-derived levels of radioactivity or radionuclide concentrations in various media that can be measured in the field and compared to the PAGs to quickly determine if protective actions are warranted. I.e can certain roads, bridges or metro systems be used, can the public return to their homes or businesses, can the public consume certain foods, etc. An operational guidelines manual, developed by a federal interagency working group led by the Department of Energy (DOE), was published in 2009 as the Preliminary Report on Operational Guidelines Developed for Use in Emergency Response to a Radiological Dispersal Device Incident, with its companion software RESidual RADiation (RESRAD)-RDD. With the development of the new PAG Manual (Interim Final 2013) by the EPA, an interagency working group was created under the auspices of the ISCORS to develop a revised operational guidelines manual that would reflect the changes by EPA’s new PAG Manual, new best available technology based on new dosimetric models (ICRP 60+), include operational guidelines for IND’s and increase the amount of radionuclides in the OGT Manual from 11 radioisotopes to 55. The new manual is scheduled for publication in 2015.

380

Resolution enhancement of lung 4D-CT via group-sparsity  

SciTech Connect (OSTI)

Purpose: 4D-CT typically delivers more accurate information about anatomical structures in the lung, over 3D-CT, due to its ability to capture visual information of the lung motion across different respiratory phases. This helps to better determine the dose during radiation therapy for lung cancer. However, a critical concern with 4D-CT that substantially compromises this advantage is the low superior-inferior resolution due to less number of acquired slices, in order to control the CT radiation dose. To address this limitation, the authors propose an approach to reconstruct missing intermediate slices, so as to improve the superior-inferior resolution.Methods: In this method the authors exploit the observation that sampling information across respiratory phases in 4D-CT can be complimentary due to lung motion. The authors’ approach uses this locally complimentary information across phases in a patch-based sparse-representation framework. Moreover, unlike some recent approaches that treat local patches independently, the authors’ approach employs the group-sparsity framework that imposes neighborhood and similarity constraints between patches. This helps in mitigating the trade-off between noise robustness and structure preservation, which is an important consideration in resolution enhancement. The authors discuss the regularizing ability of group-sparsity, which helps in reducing the effect of noise and enables better structural localization and enhancement.Results: The authors perform extensive experiments on the publicly available DIR-Lab Lung 4D-CT dataset [R. Castillo, E. Castillo, R. Guerra, V. Johnson, T. McPhail, A. Garg, and T. Guerrero, “A framework for evaluation of deformable image registration spatial accuracy using large landmark point sets,” Phys. Med. Biol. 54, 1849–1870 (2009)]. First, the authors carry out empirical parametric analysis of some important parameters in their approach. The authors then demonstrate, qualitatively as well as quantitatively, the ability of their approach to achieve more accurate and better localized results over bicubic interpolation as well as a related state-of-the-art approach. The authors also show results on some datasets with tumor, to further emphasize the clinical importance of their method.Conclusions: The authors have proposed to improve the superior-inferior resolution of 4D-CT by estimating intermediate slices. The authors’ approach exploits neighboring constraints in the group-sparsity framework, toward the goal of achieving better localization and noise robustness. The authors’ results are encouraging, and positively demonstrate the role of group-sparsity for 4D-CT resolution enhancement.

Bhavsar, Arnav; Wu, Guorong; Shen, Dinggang [Department of Radiology and BRIC, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)] [Department of Radiology and BRIC, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Lian, Jun [Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)] [Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)

2013-12-15T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

E-Print Network 3.0 - a549 lung carcinoma Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

GPC3 Is a Potential Lung Tumor Suppressor Summary: (22, 23). Two lung carcinoma cell lines (A549 and NCI-H460) were incubated with viral supernatant... function in lung...

382

Cardiac-Sparing Whole Lung IMRT in Children With Lung Metastasis  

SciTech Connect (OSTI)

Purpose: To demonstrate the dosimetric advantages of cardiac-sparing (CS) intensity modulated radiation therapy (IMRT) in children undergoing whole lung irradiation (WLI). Methods and Materials: Chest CT scans of 22 children who underwent simulation with 3-dimensional (n=10) or 4-dimensional (n=12) techniques were used for this study. Treatment planning was performed using standard anteroposterior-posteroanterior (S-RT) technique and CS-IMRT. Left and right flank fields were added to WLI fields to determine whether CS-IMRT offered any added protection to normal tissues at the junction between these fields. The radiation dose to the lung PTV, cardiac structures, liver, and thyroid were analyzed and compared. Results: CS-IMRT had 4 significant advantages over S-RT: (1) superior cardiac protection (2) superior 4-dimensional lung planning target volume coverage, (3) superior dose uniformity in the lungs with fewer hot spots, and (4) significantly lower dose to the heart when flank RT is administered after WLI. Conclusions: The use of CS-IMRT and 4-dimensional treatment planning has the potential to improve tumor control rates and reduce cardiac toxicity in children receiving WLI.

Kalapurakal, John A., E-mail: j-kalapurakal@northwestern.edu [Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois (United States); Zhang, Yunkai; Kepka, Alan; Zawislak, Brian; Sathiaseelan, Vythialingam [Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois (United States)] [Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois (United States); Rigsby, Cynthia [Medical Imaging, Children's Memorial Hospital Chicago, Chicago, Illinois (United States)] [Medical Imaging, Children's Memorial Hospital Chicago, Chicago, Illinois (United States); Gopalakrishnan, Mahesh [Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois (United States)] [Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois (United States)

2013-03-01T23:59:59.000Z

383

Depleted uranium - induced malignant transformation in human lung epithelial cells.  

Science Journals Connector (OSTI)

...Association for Cancer Research 15 April...Proc Amer Assoc Cancer Res, Volume 47, 2006 Depleted uranium - induced malignant...Proc Amer Assoc Cancer Res, Volume 47, 2006] 5215 Depleted uranium (DU) has been...

Aldona A. Karaczyn; Hong Xie; and John P. Wise

2006-04-15T23:59:59.000Z

384

Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed Natural Gas (CNG)-Powered Vehicles Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed...

385

E-Print Network 3.0 - american lung association Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

or bubble- related phenomena in lung alveoli. Let us further evaluate... COMPARISON OF MOUSE AND RABBIT LUNG DAMAGE EXPOSURE TO 30 kHz ... Source: Illinois at...

386

E-Print Network 3.0 - automated lung nodule Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Information Sciences 2 STATISTICAL MODELING OF THE LUNG NODULES IN LOW DOSE COMPUTED TOMOGRAPHY SCANS OF THE CHEST Summary: STATISTICAL MODELING OF THE LUNG NODULES IN LOW DOSE...

387

E-Print Network 3.0 - attenuates paraquat-induced lung Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

area of the lung using X-ray attenuation data... Lung Assessment Using Computer Tomography A software program that determines the weight, tissue... composition and various...

388

CancerCancer SBL101SBL101  

E-Print Network [OSTI]

CancerCancer SBL101SBL101 James Gomes School of Biological Sciences Indian Institute of Technology either Block the control point so that cell cycle continues in the absence of telomeres Acquire

Mittal, Aditya

389

Blast injuries to the lung: epidemiology and management  

Science Journals Connector (OSTI)

...Medicine, College of Medical and Dental Sciences, University of Birmingham...blast injuries|blast lung|radiology of blast lung injury|conventional...context, clinical symptoms and radiology. Symptoms may include respiratory...patients (67%) for whom role 3 radiology was available and given that...

2011-01-01T23:59:59.000Z

390

Resolution enhancement of lung 4D-CT data using multiscale interphase iterative nonlocal means  

SciTech Connect (OSTI)

Purpose: Four-dimensional computer tomography (4D-CT) has been widely used in lung cancer radiotherapy due to its capability in providing important tumor motion information. However, the prolonged scanning duration required by 4D-CT causes considerable increase in radiation dose. To minimize the radiation-related health risk, radiation dose is often reduced at the expense of interslice spatial resolution. However, inadequate resolution in 4D-CT causes artifacts and increases uncertainty in tumor localization, which eventually results in extra damages of healthy tissues during radiotherapy. In this paper, the authors propose a novel postprocessing algorithm to enhance the resolution of lung 4D-CT data. Methods: The authors' premise is that anatomical information missing in one phase can be recovered from the complementary information embedded in other phases. The authors employ a patch-based mechanism to propagate information across phases for the reconstruction of intermediate slices in the longitudinal direction, where resolution is normally the lowest. Specifically, the structurally matching and spatially nearby patches are combined for reconstruction of each patch. For greater sensitivity to anatomical details, the authors employ a quad-tree technique to adaptively partition the image for more fine-grained refinement. The authors further devise an iterative strategy for significant enhancement of anatomical details. Results: The authors evaluated their algorithm using a publicly available lung data that consist of 10 4D-CT cases. The authors' algorithm gives very promising results with significantly enhanced image structures and much less artifacts. Quantitative analysis shows that the authors' algorithm increases peak signal-to-noise ratio by 3-4 dB and the structural similarity index by 3%-5% when compared with the standard interpolation-based algorithms. Conclusions: The authors have developed a new algorithm to improve the resolution of 4D-CT. It outperforms the conventional interpolation-based approaches by producing images with the markedly improved structural clarity and greatly reduced artifacts.

Zhang Yu [School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China and Department of Radiology and BRIC, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Yap, Pew-Thian; Wu Guorong [Department of Radiology and BRIC, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Feng Qianjin; Chen Wufan [School of Biomedical Engineering, Southern Medical University, Guangzhou 510515 (China); Lian Jun [Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Shen Dinggang [Department of Radiology and BRIC, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Department of Brain and Cognitive Engineering, Korea University, Seoul 136-713 (Korea, Republic of)

2013-05-15T23:59:59.000Z

391

Dental radiology considerations in DVI incidents: A review  

Science Journals Connector (OSTI)

Multiple fatality incidents frequently have a significant forensic dental identification component. The use of radiographs, that provide objective evidence of the dentition prior to and after death is a vital part of the reconciliation procedure. Although these events share some common elements, every multiple fatality incident response has its own idiosyncrasies that require both flexibility and advance planning. The focus, from a post mortem perspective, is the making of excellent, permanent, and archival-quality images. The post mortem plan should have a capability for conventional film-based and digital imaging. Additionally, images should be produced in a radiobiologically responsible manner using optimum body-substance precautions. Finally, images (both ante mortem and post mortem) must be held in a secure fashion at a distance, protected from further hazard.

R.E. Wood; S.L. Kogon

2010-01-01T23:59:59.000Z

392

Incident Energy Dependence of pt Correlations at RHIC  

SciTech Connect (OSTI)

We present results for two-particle transverse momentum correlations, ({Delta}p{sub t,i}{Delta}p{sub t,j}), as a function of event centrality for Au+Au collisions at {radical}s{sub NN} = 20, 62, 130, and 200 GeV at the Relativistic Heavy Ion Collider. We observe correlations decreasing with centrality that are similar at all four incident energies. The correlations multiplied by the multiplicity density increase with incident energy and the centrality dependence may show evidence of processes such as thermalization, jet production, or the saturation of transverse flow. The square root of the correlations divided by the event-wise average transverse momentum per event shows little or no beam energy dependence and generally agrees with previous measurements at the Super Proton Synchrotron.

Adams, J.; Aggarwal, M.M.; Ahammed, Z.; Amonett, J.; Anderson,B.D.; Arkhipkin, D.; Averichev, G.S.; Badyal, S.K.; Bai, Y.; Balewski,J.; Barannikova, O.; Barnby, L.S.; Baudot, J.; Bekele, S.; Belaga, V.V.; Bellwied, R.; Berger, J.; Bezverkhny, B.I.; Bharadwaj, S.; Bhasin, A.; Bhati, A.K.; Bhatia, V.S.; Bichsel, H.; Billmeier, A.; Bland, L.C.; Blyth, C.O.; Bonner, B.E.; Botje, M.; Boucham, A.; Brandin, A.V.; Bravar,A.; Bystersky, M.; Cadman, R.V.; Cai, X.Z.; Caines, H.; Calderon de laBarca Sanchez, M.; Castillo, J.; Cebra, D.; Chajecki, Z.; Chaloupka, P.; Chattopadhyay, S.; Chen, H.F.; Chen, Y.; Cheng, J.; Cherney, M.; Chikanian, A.; Christie, W.; Coffin, J.P.; Cormier, T.M.; Cramer, J.G.; Crawford, H.J.; Das, D.; Das, S.; de Moura, M.M.; Derevschikov, A.A.; Didenko, L.; Dietel, T.; Dogra, S.M.; Dong, W.J.; Dong, X.; Draper, J.E.; Du, F.; Dubey, A.K.; Dunin, V.B.; Dunlop, J.C.; Dutta Mazumdar, M.R.; Eckardt, V.; Edwards, W.R.; Efimov, L.G.; Emelianov, V.; Engelage, J.; Eppley, G.; Erazmus, B.; Estienne, M.; Fachini, P.; Faivre, J.; Fatemi,R.; Fedorisin, J.; Filimonov, K.; Filip, P.; Finch, E.; Fine, V.; Fisyak,Y.; Fomenko, K.; Fu, J.; Gagliardi, C.A.; Gaillard, L.; Gans, J.; Ganti,M.S.; Gaudichet, L.; Geurts, F.; Ghazikhanian, V.; Ghosh, P.; Gonzalez,J.E.; Grachov, O.; Grebenyuk, O.; Grosnick, D.; Guertin, S.M.; Guo, Y.; Gupta, A.; Gutierrez, T.D.; Hallman, T.J.; Hamed, A.; Hardtke, D.; Harris, J.W.; Heinz, M.; Henry, T.W.; Hepplemann, S.; Hippolyte, B.; Hirsch, A.; Hjort, E.; Hoffmann, G.W.; Huang, H.Z.; Huang, S.L.; Hughes,E.W.; Humanic, T.J.; Igo, G.; Ishihara, A.; Jacobs, P.; Jacobs, W.W.; Janik, M.; Jiang, H.; Jones, P.G.; Judd, E.G.; Kabana, S.; Kang, K.; Kaplan, M.; Keane, D.; Khodyrev, V.Yu.; Kiryluk, J.; Kisiel, A.; Kislov,E.M.; Klay, J.; Klein, S.R.; Koetke, D.D.; Kollegger, T.; Kopytine, M.; Kotchenda, L.; Kramer, M.; Kravtsov, P.; Kravtsov, V.I.; Krueger, K.; Kuhn, C.; Kulikov, A.I.; Kumar, A.; Kutuev, R.Kh.; et al.

2005-04-29T23:59:59.000Z

393

Abstract B21: Disruption of NF?B/Stat3 interaction as a potential therapeutic avenue for pancreatic cancer management.  

Science Journals Connector (OSTI)

...Clinical and Biological Sciences, University of Torino...Stage Lung Cancer-New Approaches to Evaluation and Treatment...surgery, and basic science were presented from...prognosis, and appropriate management of screen-detected...these models. Promising approaches include gene expression...

Jingjing Gong; Jianping Xie; Izhar Batth; James W. Freeman; Divya Chakravarthy; and Addanki pratap Kumar

2012-07-15T23:59:59.000Z

394

Effects of the Kava Chalcone Flavokawain A Differ in Bladder Cancer Cells with Wild-type versus Mutant p53  

Science Journals Connector (OSTI)

...and treated with daily oral vehicle (10% grain alcohol in 0...rate of tumors compared with vehicle control (ANOVA, P 0.01...daily dosing was begun with vehicle or flavokawain A at 50 mg...Hankin JH, Bach F et al . An ecological study of diet and lung cancer...

Yaxiong Tang; Anne R. Simoneau; Jun Xie; Babbak Shahandeh; and Xiaolin Zi

2008-11-01T23:59:59.000Z

395

Performance of Prediction Models for BRCA Mutation Carriage in Three Racial/Ethnic Groups: Findings from the Northern California Breast Cancer Family Registry  

Science Journals Connector (OSTI)

...Felberg 2 Amanda I. Phipps 3 Dee W. West 2 3 Alice S. Whittemore 2 Requests for...of Spanish ancestry from the San Luis Valley, Colorado. Cancer 2003;98:597-602. 39 Clarke CA, Glaser SL, West DW, et al. Breast cancer incidence...

Allison W. Kurian; Gail D. Gong; Esther M. John; Alexander Miron; Anna Felberg; Amanda I. Phipps; Dee W. West; and Alice S. Whittemore

2009-04-01T23:59:59.000Z

396

The National Cancer Institute,  

E-Print Network [OSTI]

The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

397

CANCER BIOLOGY Infectioustumourcells  

E-Print Network [OSTI]

CANCER BIOLOGY Infectioustumourcells David Dingli and Martin A. Nowak Cancer cells are generally infectious agents and be transmitted between individuals. The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer- promoting

Nowak, Martin A.

398

Cancer vaccines: Material breach  

Science Journals Connector (OSTI)

... Willem Overwijk, a tumour immunologist who studies melanoma vaccines at MD Anderson Cancer Center in Houston, ...

Elie Dolgin

2013-12-18T23:59:59.000Z

399

CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER  

E-Print Network [OSTI]

CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

Sherman, S. Murray

400

Physiological Interaction of Heart and Lung in Thoracic Irradiation  

SciTech Connect (OSTI)

Introduction: The risk of early radiation-induced lung toxicity (RILT) limits the dose and efficacy of radiation therapy of thoracic tumors. In addition to lung dose, coirradiation of the heart is a known risk factor in the development RILT. The aim of this study was to identify the underlying physiology of the interaction between lung and heart in thoracic irradiation. Methods and Materials: Rat hearts, lungs, or both were irradiated to 20 Gy using high-precision proton beams. Cardiopulmonary performance was assessed using breathing rate measurements and F{sup 18}-fluorodeoxyglucose positron emission tomography ({sup 18}F-FDG-PET) scans biweekly and left- and right-sided cardiac hemodynamic measurements and histopathology analysis at 8 weeks postirradiation. Results: Two to 12 weeks after heart irradiation, a pronounced defect in the uptake of {sup 18}F-FDG in the left ventricle (LV) was observed. At 8 weeks postirradiation, this coincided with LV perivascular fibrosis, an increase in LV end-diastolic pressure, and pulmonary edema in the shielded lungs. Lung irradiation alone not only increased pulmonary artery pressure and perivascular edema but also induced an increased LV relaxation time. Combined irradiation of lung and heart induced pronounced increases in LV end-diastolic pressure and relaxation time, in addition to an increase in right ventricle end-diastolic pressure, indicative of biventricular diastolic dysfunction. Moreover, enhanced pulmonary edema, inflammation and fibrosis were also observed. Conclusions: Both lung and heart irradiation cause cardiac and pulmonary toxicity via different mechanisms. Thus, when combined, the loss of cardiopulmonary performance is intensified further, explaining the deleterious effects of heart and lung coirradiation. Our findings show for the first time the physiological mechanism underlying the development of a multiorgan complication, RILT. Reduction of dose to either of these organs offers new opportunities to improve radiation therapy treatment of thoracic tumors, potentially facilitating increased treatment doses and tumor control.

Ghobadi, Ghazaleh; Veen, Sonja van der [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands) [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Bartelds, Beatrijs [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Boer, Rudolf A. de [Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Dickinson, Michael G. [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Jong, Johan R. de [Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Faber, Hette; Niemantsverdriet, Maarten [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands) [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Brandenburg, Sytze [Kernfysisch Versneller Instituut, University of Groningen, Groningen (Netherlands)] [Kernfysisch Versneller Instituut, University of Groningen, Groningen (Netherlands); Berger, Rolf M.F. [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Center for Congenital Heart Disease, Beatrix Children Hospital, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Langendijk, Johannes A. [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)] [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Coppes, Robert P. [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands) [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Luijk, Peter van, E-mail: p.van.luijk@umcg.nl [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)

2012-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Predicting scorpion sting incidence in an endemic region using climatological variables*  

E-Print Network [OSTI]

Predicting scorpion sting incidence in an endemic region using climatological variables* G. CHOWELL in Mexico. We analysed the significance of climatological variables to predict the incidence of scorpion seasonal pattern that correlates to climatological variables. An increase in scorpion activity

Chowell, Gerardo

402

Active and Knowledge-based Process Safety Incident Retrieval System  

E-Print Network [OSTI]

topics saved for quick access. The database search system developed in this research is similar to that of CCPS-PSID in the way that it offers folder search and word search. However, the PSID has a single level of folders (keyword list... maximum of four levels. Moreover, word search within a folder has also been included for the search system, which further improves searching capabilities. 5 Some of the existing incident databases that are open to public or accessible by Mary Kay O...

Khan, Sara Shammni

2011-10-21T23:59:59.000Z

403

Studies on transmission and incidence of Trypanosoma theileri, Laveran 1902  

E-Print Network [OSTI]

vector. c) Ingestion of the insect vector. Sane evidence of intrauterirm transmission has been provided by several researchers. Dirc)anan, Manthei and Frank (1957) found T. theileri in the stanach of an ~ bovine fetus. Iundholm, Stors and Mc... were infected with T. theileri; the 2 calves were free fran infectian. Kohl-Yakimoff, Yakimoff and 13e)censky (1913) in Saint Peters- bourg, Russia, examined 14 cattle for T. theileri and faund a 35. 6rr incidence of infecticnr in another survey...

Betancourt Echeverry, Antonio

1972-01-01T23:59:59.000Z

404

Incidence of Childhood Obesity in the United States  

Science Journals Connector (OSTI)

...stratified the estimates of prevalence and incidence according to sex, quintile of the kindergartners' household socioeconomic status, and race or ethnic group (non-Hispanic white, non-Hispanic black, Hispanic, or "other"). To understand the importance of weight early in life, we also stratified the data according... According to this report, nearly half of children who became obese between the ages of 5 and 14 years had been overweight and 75% had been above the 70th percentile for BMI at the start of kindergarten. Focusing on early childhood obesity may be important in stemming the epidemic.

Cunningham S.A.Kramer M.R.Narayan K.M.V.

2014-01-30T23:59:59.000Z

405

ION GNSS 2004, Sept. 21-24, Long Beach, CA Automated Traffic Incident Detection with GPS  

E-Print Network [OSTI]

in Intelligent Transportation Systems (ITS) and in-vehicle telematics systems. ABSTRACT Traffic congestion can. Traffic Incident Detection Systems (IDS) use a variety of technologies to detect incidents so system for traffic incident detection. The system performance analysis was conducted using a combination

Calgary, University of

406

Weekly Security Incident Log Period of Jun 24 -Jun 30, 2013  

E-Print Network [OSTI]

his drinking water bottle had been tampered with while it was left unattended. Toronto Police were. The vehicle driver left the scene without reporting the incident. 6/26/2013 10:13 AM Motor Vehicle Incident rear quarter panel. No injuries were reported. 6/26/2013 07:07 PM Motor Vehicle Incident 2013

407

Weekly Security Incident Log Period of Jun 2 -Jun 8, 2014  

E-Print Network [OSTI]

. A description of a suspect was obtained. 6/4/2014 06:39 PM Theft, Under 2014-000979 ROSS BUILDING - NORTH TOWERWeekly Security Incident Log Period of Jun 2 - Jun 8, 2014 Incident No. Reported Date Building Name lot. No injuries were reported. 6/2/2014 06:19 PM Motor Vehicle Incident 2014-000960 TECHNOLOGY

408

Weekly Security Incident Log Period of Nov 27 -Dec 2, 2012  

E-Print Network [OSTI]

was obtained. 11/28/2012 01:41 PM Suspicious Person 2012-002119 ROSS BUILDING - NORTH TOWER Private PropertyWeekly Security Incident Log Period of Nov 27 - Dec 2, 2012 Incident No. Reported Date Building:41 AM Theft, Under Weekly Security Incident Log Printed: 12/3/2012 3:18:11 PM 1 Period of Nov 27 - Dec 2

409

Paul Workman Cancer Research UK Cancer Therapeutics Unit  

E-Print Network [OSTI]

Paul Workman Cancer Research UK Cancer Therapeutics Unit Institute of Cancer Research/Royal Marsden Hospital Sutton, Surrey SM2 5NG UK ian.collins@icr.ac.uk Drugging the cancer genome: The challenges therapeutic agents Personalised diagnosis and treatment Exploiting cancer biology and the cancer genome

410

E-Print Network 3.0 - acute pancreatitis incidence Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Markers in Duodenal Mucosa Predict the Presence of Pancreatic Cancer Yang Liu,1 Randall E... Shah,2 Curtis Hall,2 and Vadim Backman1 Abstract Purpose: Pancreatic cancer...

411

Targeting Ornithine Decarboxylase for the Prevention of Nonmelanoma Skin Cancer in Humans  

Science Journals Connector (OSTI)

...incidence between 1977_1978 and 1998-1999 in Northcentral New Mexico. Cancer Epidemiol Biomarkers Prev 2003;12:1105-8. 3...732-6. 8 Thompson SC , Jolley D, Marks R. Reduction of solar keratoses by regular sunscreen use. N Engl J Med 1993;329...

Craig A. Elmets and Mohammad Athar

2010-01-01T23:59:59.000Z

412

Vitamin D Suppresses Leptin Stimulation of Cancer Growth through microRNA  

Science Journals Connector (OSTI)

...crucial role in regulating appetite and energy balance, are strongly correlated with...1206-10. 7. Reeves GK , Pirie K, Beral V, Green J, Spencer E, Bull D, et alCancer incidence...2008;17:902-12. 46. Olsen CM , Green AC, Whiteman DC, Sadeghi S, Kolahdooz...

Ravi Kasiappan; Yuefeng Sun; Panida Lungchukiet; Waise Quarni; Xiaohong Zhang; and Wenlong Bai

2014-11-01T23:59:59.000Z

413

ORISE: DeepwaterHorizon and Nuclear & Radiological Incidents  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Wi l l i a m H a l e y Wi l l i a m H a l e y B r a d P o t t e r C o mm o n C h a l l e n g e s a n d S o l u t i o n s J u n e 2 0 1 1 D e e p w a t e r H o r i z o n a n dN u c l e a r & R a d i o l o g i c a l I n c i d e n t s The 2010 Deepwater Horizon oil spill shares many of the same challenges associated with a radiological incident like the one considered in the Empire 09 1 exercise or even a much larger nuclear incident. By analyzing experiences during Deepwater Horizon, these challenges can be identified by the interagency in advance of a radiological or nuclear emergency and solutions made available. Establishing and staffing a UnifiEd Command strUCtUrE The demands of Deepwater Horizon challenged the traditional response construct envisioned by national planning systems.

414

Lung function of preterm infants before and after viral infections  

Science Journals Connector (OSTI)

Our aim was to determine whether viral lower respiratory tract infections (LRTIs) adversely affect prematurely born infants’ lung function at follow up. Seventy infants, median gestational age 34 (range, 24–35...

Simon B. Drysdale; Jessica Lo; Michael Prendergast…

2014-11-01T23:59:59.000Z

415

Functional lung imaging in humans using Positron Emission Tomography  

E-Print Network [OSTI]

This thesis deals with a method of functional lung imaging using Positron Emission Tomography (PET). In this technique, a radioactive tracer, nitrogen-13, is dissolved in saline solution, and injected into a peripheral ...

Layfield, Dominick, 1971-

2003-01-01T23:59:59.000Z

416

Chin-Lung Wang Professor in Mathematics, NTU  

E-Print Network [OSTI]

Chin-Lung Wang Position Professor in Mathematics, NTU Research Fields Algebraic Geometry to the non-vanishing conjecture for a pseudo-effective adjoint divisor. I am interested in studying the an

Huang, Su-Yun

417

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer  

Science Journals Connector (OSTI)

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer ... NIR fluorescence images of the dissected brains were obtained using the Xenogen IVIS spectrum imager (Caliper Life Sciences, Inc., Hopkinton, MA). ... Immunohistochemical and morphometric analyses demonstrate that the density of blood vessels within experimental metastases in brains of mice or in clinical specimen of human lung cancer brain metastases is lower than that in the adjacent tumor-free brain parenchyma. ...

Jason Li; Ping Cai; Alireza Shalviri; Jeffrey T. Henderson; Chunsheng He; Warren D. Foltz; Preethy Prasad; Peter M. Brodersen; Yonghong Chen; Ralph DaCosta; Andrew Michael Rauth; Xiao Yu Wu

2014-10-13T23:59:59.000Z

418

SMITH NORMAL FORMS OF INCIDENCE MATRICES Abstract. A brief introduction is given to the topic of Smith normal forms of incidence  

E-Print Network [OSTI]

SMITH NORMAL FORMS OF INCIDENCE MATRICES PETER SIN Abstract. A brief introduction is given to the topic of Smith normal forms of incidence matrices. A general discussion of techniques is illustrated, the fundamental invariant is the Smith normal form of A, whose definition we now recall. A square integer matrix

Sin, Peter

419

Polycyclic Aromatic Hydrocarbon Exposure in Household Air Pollution from Solid Fuel Combustion among the Female Population of Xuanwei and Fuyuan Counties, China  

Science Journals Connector (OSTI)

Exposure to polycyclic aromatic hydrocarbons (PAHs) from burning “smoky” (bituminous) coal has been implicated as a cause of the high lung cancer incidence in the counties of Xuanwei and Fuyuan, China. Little is known about variations in PAH exposure from ...

George S. Downward; Wei Hu; Nat Rothman; Boris Reiss; Guoping Wu; Fusheng Wei; Robert S. Chapman; Lutzen Portengen; Lan Qing; Roel Vermeulen

2014-11-13T23:59:59.000Z

420

Probability of Cancer in Pulmonary Nodules Detected on First Screening CT  

Science Journals Connector (OSTI)

...nodules; one-sided 97.5% CI, 0 to 0.006). The location of a nodule was evaluated according to lobar distribution. A larger number of nodules and a larger number of cancers were observed in the left upper and right upper lobes than in the left or right lower lobes or the right middle lobe (Table 1). For... Using data from two large data sets of lung-cancer screening by CT, the authors identified factors that increased the likelihood that a nodule was malignant, including older age, female sex, nodule location in the upper lobe, lower nodule count, and certain nodule features.

McWilliams A.; Tammemagi M.C.; Mayo J.R.

2013-09-05T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Cancer Research Beckman Institute  

E-Print Network [OSTI]

Cancer Research Beckman Institute FOR ADVANCED SCIENCE AND TECHNOLOGY #12;T The medical and scientific worlds have known for many years that in order to truly understand and treat cancer, the fight has and cancerous tumors have to first be visualized at the smallest scales possible, and then treated in the most

Illinois at Urbana-Champaign, University of

422

Simulation of heavy ion induced electron yield at grazing incidence  

Science Journals Connector (OSTI)

We compare simulations to experiments measuring electron yield from heavy ions striking metal surfaces, in particular at grazing incidence, for 1.0 MeV potassium and 182.0 MeV gold ions striking stainless steel as measured in two recent experiments. We find the electron yield is proportional to within 3% for the potassium experiments and 13% for the gold experiments to the simulated energy deposited by the ions in a thin (?20???Å) layer at the target surface. We discuss how nonequilibrium stopping and ion wake fields may account for the larger disagreement with the gold experiments. An analytic estimate based on specular reflection predicts the peak in simulated and measured electron yield as a function of angle to within a few percent.

P. H. Stoltz; S. Veitzer; R. Cohen; A. W. Molvik; J.-L. Vay

2004-10-12T23:59:59.000Z

423

Synthetic and Naturally Occurring Hydrazines as Possible Cancer Causative Agents  

Science Journals Connector (OSTI)

...brain, lungs, blood vessels, liver, breasts...components of rocket fuels (26); carbamyl hydrazine...Lungs Mice Lungs, blood vessels Mice Lungs Rats Lymphoreticular...Intestine Lungs, blood vessels MiceLungsp.o.39MiceLungs...States A . bisporus consumption (production plus imports...

Bela Toth

1975-12-01T23:59:59.000Z

424

Mortality in the Randomized, Controlled Lung Intergroup Trial of Isotretinoin  

Science Journals Connector (OSTI)

...science approaches to cancer health disparity reduction. Methods...a SWOT analysis in cancer health disparities among Region 4...opportunities, and threats. Implications/Next Steps: Regional networks of health disparities researchers are...

J. Jack Lee; Lei Feng; Daniel S. Reshef; Anita L. Sabichi; Brendell Williams; Waree Rinsurongkawong; Ignacio I. Wistuba; Reuben Lotan; and Scott M. Lippman

2010-06-01T23:59:59.000Z

425

Volumetric modulated arc radiotherapy for esophageal cancer  

SciTech Connect (OSTI)

A treatment planning study was performed to evaluate the performance of volumetric arc modulation with RapidArc (RA) against 3D conformal radiation therapy (3D-CRT) and conventional intensity-modulated radiation therapy (IMRT) techniques for esophageal cancer. Computed tomgraphy scans of 10 patients were included in the study. 3D-CRT, 4-field IMRT, and single-arc and double-arc RA plans were generated with the aim to spare organs at risk (OAR) and healthy tissue while enforcing highly conformal target coverage. The planning objective was to deliver 54 Gy to the planning target volume (PTV) in 30 fractions. Plans were evaluated based on target conformity and dose-volume histograms of organs at risk (lung, spinal cord, and heart). The monitor unit (MU) and treatment delivery time were also evaluated to measure the treatment efficiency. The IMRT plan improves target conformity and spares OAR when compared with 3D-CRT. Target conformity improved with RA plans compared with IMRT. The mean lung dose was similar in all techniques. However, RA plans showed a reduction in the volume of the lung irradiated at V{sub 20Gy} and V{sub 30Gy} dose levels (range, 4.62-17.98%) compared with IMRT plans. The mean dose and D{sub 35%} of heart for the RA plans were better than the IMRT by 0.5-5.8%. Mean V{sub 10Gy} and integral dose to healthy tissue were almost similar in all techniques. But RA plans resulted in a reduced low-level dose bath (15-20 Gy) in the range of 14-16% compared with IMRT plans. The average MU needed to deliver the prescribed dose by RA technique was reduced by 20-25% compared with IMRT technique. The preliminary study on RA for esophageal cancers showed improvements in sparing OAR and healthy tissue with reduced beam-on time, whereas only double-arc RA offered improved target coverage compared with IMRT and 3D-CRT plans.

Vivekanandan, Nagarajan, E-mail: viveknaren@hotmail.com [Department of Medical Physics, Cancer Institute, Chennai (India); Sriram, Padmanaban; Syam Kumar, S.A.; Bhuvaneswari, Narayanan; Saranya, Kamalakannan [Department of Medical Physics, Cancer Institute, Chennai (India)

2012-04-01T23:59:59.000Z

426

Handbook of Cancer Survivorship  

Science Journals Connector (OSTI)

...problems or reduce their effects? Michael Feuerstein has assembled a distinguished cadre of scientists to answer some of these questions in the Handbook of Cancer Survivorship. To my knowledge, this is the first book that targets health care professionals who work with survivors of adult cancer. Most... The victories over cancer in the past three decades have given us much to celebrate. In the United States alone, there are now more than 10.5 million cancer survivors. We have also learned that there can be a cost to curing cancer, and thus the emphasis ...

Oeffinger K.C.

2007-06-14T23:59:59.000Z

427

Volumetric Image Guidance Using Carina vs Spine as Registration Landmarks for Conventionally Fractionated Lung Radiotherapy  

SciTech Connect (OSTI)

Purpose: To compare the relative accuracy of 2 image guided radiation therapy methods using carina vs spine as landmarks and then to identify which landmark is superior relative to tumor coverage. Methods and Materials: For 98 lung patients, 2596 daily image-guidance cone-beam computed tomography scans were analyzed. Tattoos were used for initial patient alignment; then, spine and carina registrations were performed independently. A separate analysis assessed the adequacy of gross tumor volume, internal target volume, and planning target volume coverage on cone-beam computed tomography using the initial, middle, and final fractions of radiation therapy. Coverage was recorded for primary tumor (T), nodes (N), and combined target (T+N). Three scenarios were compared: tattoos alignment, spine registration, and carina registration. Results: Spine and carina registrations identified setup errors {>=}5 mm in 35% and 46% of fractions, respectively. The mean vector difference between spine and carina matching had a magnitude of 3.3 mm. Spine and carina improved combined target coverage, compared with tattoos, in 50% and 34% (spine) to 54% and 46% (carina) of the first and final fractions, respectively. Carina matching showed greater combined target coverage in 17% and 23% of fractions for the first and final fractions, respectively; with spine matching, this was only observed in 4% (first) and 6% (final) of fractions. Carina matching provided superior nodes coverage at the end of radiation compared with spine matching (P=.0006), without compromising primary tumor coverage. Conclusion: Frequent patient setup errors occur in locally advanced lung cancer patients. Spine and carina registrations improved combined target coverage throughout the treatment course, but carina matching provided superior combined target coverage.

Lavoie, Caroline; Higgins, Jane; Bissonnette, Jean-Pierre [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, M5G 2M9 (Canada)] [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, M5G 2M9 (Canada); Le, Lisa W. [Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario, M5G 2M9 (Canada)] [Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario, M5G 2M9 (Canada); Sun, Alexander; Brade, Anthony; Hope, Andrew; Cho, John [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, M5G 2M9 (Canada)] [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, M5G 2M9 (Canada); Bezjak, Andrea, E-mail: andrea.bezjak@rmp.uhn.on.ca [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, M5G 2M9 (Canada)] [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, M5G 2M9 (Canada)

2012-12-01T23:59:59.000Z

428

A block matching-based registration algorithm for localization of locally advanced lung tumors  

SciTech Connect (OSTI)

Purpose: To implement and evaluate a block matching-based registration (BMR) algorithm for locally advanced lung tumor localization during image-guided radiotherapy. Methods: Small (1 cm{sup 3}), nonoverlapping image subvolumes (“blocks”) were automatically identified on the planning image to cover the tumor surface using a measure of the local intensity gradient. Blocks were independently and automatically registered to the on-treatment image using a rigid transform. To improve speed and robustness, registrations were performed iteratively from coarse to fine image resolution. At each resolution, all block displacements having a near-maximum similarity score were stored. From this list, a single displacement vector for each block was iteratively selected which maximized the consistency of displacement vectors across immediately neighboring blocks. These selected displacements were regularized using a median filter before proceeding to registrations at finer image resolutions. After evaluating all image resolutions, the global rigid transform of the on-treatment image was computed using a Procrustes analysis, providing the couch shift for patient setup correction. This algorithm was evaluated for 18 locally advanced lung cancer patients, each with 4–7 weekly on-treatment computed tomography scans having physician-delineated gross tumor volumes. Volume overlap (VO) and border displacement errors (BDE) were calculated relative to the nominal physician-identified targets to establish residual error after registration. Results: Implementation of multiresolution registration improved block matching accuracy by 39% compared to registration using only the full resolution images. By also considering multiple potential displacements per block, initial errors were reduced by 65%. Using the final implementation of the BMR algorithm, VO was significantly improved from 77% ± 21% (range: 0%–100%) in the initial bony alignment to 91% ± 8% (range: 56%–100%;p < 0.001). Left-right, anterior-posterior, and superior-inferior systematic BDE were 3.2, 2.4, and 4.4 mm, respectively, with random BDE of 2.4, 2.1, and 2.7 mm. Margins required to include both localization and delineation uncertainties ranged from 5.0 to 11.7 mm, an average of 40% less than required for bony alignment. Conclusions: BMR is a promising approach for automatic lung tumor localization. Further evaluation is warranted to assess the accuracy and robustness of BMR against other potential localization strategies.

Robertson, Scott P.; Weiss, Elisabeth; Hugo, Geoffrey D., E-mail: gdhugo@vcu.edu [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, 23298 (United States)

2014-04-15T23:59:59.000Z

429

Interfractional Reproducibility of Lung Tumor Location Using Various Methods of Respiratory Motion Mitigation  

SciTech Connect (OSTI)

Purpose: To determine interfractional reproducibility of the location of lung tumors using respiratory motion mitigation. Methods and Materials: Free-breathing four-dimensional computed tomography (CT) data sets and CT data sets during breath hold were acquired weekly for 17 patients undergoing treatment for non-small-cell lung cancer. Distances between the center of the gross tumor volume (GTV) and a reproducible bony reference point under conditions of breath hold on end inspiration (EI) and end expiration (EE) and during free breathing on the 0% phase (corresponding to EI) and 50% phase (corresponding to EE) were analyzed for interfractional reproducibility. Systematic uncertainties in tumor location were determined as the difference in distance between the GTV center on the first CT data set and the mean location of GTV centers on the subsequent data sets. Random uncertainties in tumor location were determined as the standard deviation of the distances between the GTV centers and the bony reference points. Margins to account for systematic and random interfractional variations were estimated based on these uncertainties. Results: Mean values of interfractional setup uncertainties were as follows: systematic uncertainties-EI, 0.3 cm; EE, 0.2 cm; 0% phase, 0.3 cm; and 50% phase, 0.3 cm; and random uncertainties-EI, 0.3 cm; EE, 0.3 cm; 0% phase, 0.3 cm; and 50% phase, 0.3 cm. There does not appear to be any correlation between uncertainties and GTV size, but there appears to be a weak positive correlation between uncertainties and the magnitude of GTV excursion. Conclusions: Voluntary breath hold and gating on either EI or EE appear to be equally reliable methods of ensuring the reproducibility of lung tumor position. We recommend setup margins of 0.3 cm if using cone-beam CT or kilovoltage X-ray with fiducials and aligning directly to the tumor and 0.8 cm when aligning to a nearby bony surrogate using cone-beam CT or kilovoltage X-ray.

Starkschall, George, E-mail: gstarksc@mdanderson.or [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Balter, Peter [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Britton, Keith [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); McAleer, Mary F.; Cox, James D. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Mohan, Radhe [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

2011-02-01T23:59:59.000Z

430

Neutron scattering by rough surfaces at grazing incidence  

Science Journals Connector (OSTI)

There are a number of calculations in the literature of the effect of statistical surface roughness on the specular and diffuse scattering of neutrons and x rays which impinge on surfaces at grazing incidence. These calculations do not agree with one another and in some cases lack internal consistency. In this paper I show that these discrepancies can be resolved within the distorted-wave Born approximation. The result I obtain for the specular reflectivity is the widely used version of Nevot and Croce, while that for the diffuse scattering is the same as a recent calculation by Sinha, Sirota, Garoff, and Stanley. The approximations made by Nevot and Croce are clearly revealed by the distorted-wave Born approximation. A simple numerical algorithm is proposed for the calculation of diffuse scattering from a surface whose roughness is self-affine, and the form of the scattering is calculated for a range of parameters within this model. The calculation of diffusion scattering is extended in this paper to the case of films with rough surfaces. Correlation between roughness at the two film surfaces is considered and shown to be important for the description of neutron reflectivity data obtained with a thin film of titanium deposited on a sapphire substrate.

Roger Pynn

1992-01-01T23:59:59.000Z

431

Interferometric results from the Boeing grazing incidence FEL ring resonator  

Science Journals Connector (OSTI)

The Boeing HAP (High Average Power) experiment was reconfigured throughout 1989–1990 to incorporate a grazing incidence, 133 m round-trip ring resonator. Initial spectra, mode stability, coherence length, and interferometric wavefront quality measurements have been taken. This paper reports on the optical measurement techniques and data used to characterize the resonator optical output as having an optical path difference (OPD) of 2.0 to 2.5 optical wavelengths. A basic data-reduction methodology and analysis supporting the subtraction of effects caused by the 7 × beam reducer, fold mirrors, and the radial shear interferometer itself Noteworthy observations, such as the ability to overlay interferometric fringe data over the length of a macropulse (? 180 micropulses) without destroying the fringe visibility, and the occurrence of centrally localized (? 30% of the diameter) disturbances of the fringe pattern are also discussed. Coherence length measurements, made using the interferometer, showed the coherence length to be between 64 and 120 ?m. Attempts to measure the micropulse-to-micropulse mode stability were made and are discussed as well.

D.A. Byrd; S.C. Bender; E.L. Miller; D.H. Dowell

1992-01-01T23:59:59.000Z

432

Cancer Stem Cells in Hepatocellular Cancer  

Science Journals Connector (OSTI)

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and typically portends a poor prognosis with a median survival ranging from 6 to 16 months. In the United States, a total of 24,120 new ...

Russell C. Langan; Itzhak Avital

2011-01-01T23:59:59.000Z

433

The incidence and prevalence of hypertension in the Province of Quebec.  

E-Print Network [OSTI]

??The objectives of this study were to estimate the prevalence, incidence and lifetime risk of developing hypertension after a given age in the Province of… (more)

Vallée, Michel.

2008-01-01T23:59:59.000Z

434

E-Print Network 3.0 - analysing healthcare incident Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

, many of the telemedicine incidents reported to MAUDE demonstrate that ... Source: Johnson, Chris - Department of Computing Science, University of Glasgow Collection: Computer...

435

One step closer to the efficient management of speed-related rail incidents  

Science Journals Connector (OSTI)

This paper aims to shed light on frequent and recurring rail-related excess speed incidents observed in the largest railway company in Paris, France, the RATP. Based on internal examples in the RATP transportation rail system, we will identify, by means of a return-on experience method, the main causes behind these incidents. The causes may be of a diverse nature and, if identified, can facilitate the analysis of each speed-related incident. This study, therefore, aims to demonstrate how to better address and efficiently manage such incidents with a view to revealing the dysfunctional elements within the system, deal with them efficiently and, thus, reduce their frequency and scale.

Cheila Duarte Colardelle; Jacques Valancogne; Stephanie Fond

2003-01-01T23:59:59.000Z

436

Micropixe as a tool to search for uranium-bearing particles in lung tissues  

SciTech Connect (OSTI)

A proton microbeam is proposed as a tool to search for uranium-bearing particles in lung tissues. Preliminary experiments have been undertaken by irradiating with protons lung tissues of dogs previously exposed to uranium ore. 7 references.

Paschoa, A.S.; Wrenn, S.C.; Miller, M.E.; Jones, K.W.; Cholewa, M.; Hanson, A.L.

1982-01-01T23:59:59.000Z

437

Precision-cut lung slices: a novel model for respiratory tract toxicology  

E-Print Network [OSTI]

slice model as a toxicological tool was accomplished by examining several biochemical parameters of functional viability and correlating them with histologic parameters in control lung slices. In addition, comparative studies utilizing rat and mouse lung...

Schwade, Lisa Schier

2012-06-07T23:59:59.000Z

438

Major Shifts in the Spatio-Temporal Distribution of Lung Antioxidant Enzymes during Influenza Pneumonia  

E-Print Network [OSTI]

With the incessant challenge of exposure to the air we breathe, lung tissue suffers the highest levels of oxygen tension and thus requires robust antioxidant defenses. Furthermore, following injury or infection, lung tissue ...

Yamada, Yoshiyuki

439

E-Print Network 3.0 - a549 human lung Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

GPC3 Is a Potential Lung Tumor Suppressor Summary: (22, 23). Two lung carcinoma cell lines (A549 and NCI-H460) were incubated with viral supernatant... . Pharmacologic Unmasking...

440

E-Print Network 3.0 - a549 lung cells Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

GPC3 Is a Potential Lung Tumor Suppressor Summary: (22, 23). Two lung carcinoma cell lines (A549 and NCI-H460) were incubated with viral supernatant... . Pharmacologic Unmasking...

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

The Occurrence of Mycoplasmas in the Lungs of Swine in Gran Canaria (Spain)  

Science Journals Connector (OSTI)

The study was conducted to investigate the mycoplasmal flora in the lungs of pigs with enzootic pneumonia at Gran Canaria (Spain). From 54 pneumonic lungs collected...Mycoplasma species. Using different species-s...

P. Assunça˜o; C. De la Fe; B. Kokotovic; O. González…

2005-08-01T23:59:59.000Z

442

Biomarkers associated with metastasis of lung cancer to brain predict patient survival  

Science Journals Connector (OSTI)

MicroRNAs influence cell physiology; alteration in miRNA regulation can be implicated in carcinogenesis and disease progression. Generally, one miRNA is predicted to regulate several hundred genes, and as a result, miRNAs could serve as a better classifier than gene expression. We combine validated miRNA expression values with imaging features to classify NSCLC brain mets from non-brain mets and identify possible biomarkers of brain mets. This research involves comprehensive miRNA expression profiling, evaluation of normalisation techniques and combination of miRNA with imaging features FDG-PET/CT and CT Scan. The biomarkers were validated on an independent data set to predict potential brain mets.

Sara Nasser; Aarati R. Ranade; Shravan Sridhar; Lisa Haney; Ronald L. Korn; Michael B. Gotway; Glen J. Weiss; Seungchan Kim

2011-01-01T23:59:59.000Z

443

Pooled Analysis of Mitochondrial DNA Copy Number and Lung Cancer Risk in Three Prospective Studies  

Science Journals Connector (OSTI)

...AACR. Introduction Mitochondria are primarily responsible for energy production in eukaryotic cells (1). Mitochondria have a singular...molecule. Mitochondria copy number (mtDNA CN) varies to meet energy needs and cope with oxidative stress (2). Oxidative stress...

Christopher Kim; Bryan A. Bassig; Wei Jie Seow; Wei Hu; Mark P. Purdue; Xiao-Ou Shu; Wen-Yi Huang; Chin-San Liu; Wen-Ling Cheng; Ta-Tsung Lin; Yong-Bing Xiang; Bu-Tian Ji; Yu-Tang Gao; Wong-Ho Chow; Satu Männistö; Stephanie J. Weinstein; Demetrius Albanes; Wei Zheng; H. Dean Hosgood; Unhee Lim; Nathaniel Rothman; Qing Lan

2014-12-01T23:59:59.000Z

444

Jaagsiekte Sheep Retrovirus Is Necessary and Sufficient To Induce a Contagious Lung Cancer in Sheep  

Science Journals Connector (OSTI)

...PCR at various time points ranging from 2 weeks...early promoter. Four newborn lambs were...hybridization of plaque lifts with two 32P-labelled...JSRV (). Three of four inoculated lambs...PCR at various time points ranging from 2 weeks...early promoter. Four newborn lambs were...

Massimo Palmarini; J. Michael Sharp; Marcelo de las Heras; Hung Fan

1999-08-01T23:59:59.000Z

445

Image-Based Chemical Screening Identifies Drug Efflux Inhibitors in Lung Cancer Cells  

Science Journals Connector (OSTI)

...high-throughput studies using the SP technique. On the other hand, recently, automated image analysis aided by high-performance computing has enabled rapid advances in the development of high-throughput image-based assays (19-22). Considering...

Xiaofeng Xia; Jian Yang; Fuhai Li; Ying Li; Xiaobo Zhou; Yue Dai; Stephen T.C. Wong

2010-10-01T23:59:59.000Z

446

Intakes of Red Meat, Processed Meat, and Meat Mutagens Increase Lung Cancer Risk  

Science Journals Connector (OSTI)

...determinations of the nitrogen and energy require ments of humans, possibly...a single cause, but for a constellation of neural, gastrointestinal...18) reviewed the problem of energy require ments, stressing the...thermogenesis, the effi ciency of energy utilization, and the activity...

Tram Kim Lam; Amanda J. Cross; Dario Consonni; Giorgia Randi; Vincenzo Bagnardi; Pier Alberto Bertazzi; Neil E. Caporaso; Rashmi Sinha; Amy F. Subar; and Maria Teresa Landi

2009-02-01T23:59:59.000Z

447

Image-Based Chemical Screening Identifies Drug Efflux Inhibitors in Lung Cancer Cells  

Science Journals Connector (OSTI)

...ICR's basic science and have invested heavily in high-throughput screening robotics, crystallography, and high-performance computing for integrative genomics and chemobiology. Crucially, we're all under one roof, co-located with the...

Xiaofeng Xia; Jian Yang; Fuhai Li; Ying Li; Xiaobo Zhou; Yue Dai; Stephen T.C. Wong

2010-10-01T23:59:59.000Z

448

Prevention of Lung Cancer by Remediation of Residential Exposure to Radon Daughters  

Science Journals Connector (OSTI)

......Exposure to Radon Daughters J.A. Mahaffey F.T. Cross J.R. Johnson M.C. Baechler The United States Bonneville Power Administration (BPA), as a part of an energy conservation programme in the states of Washington, Oregon, Idaho, Wyoming......

J.A. Mahaffey; F.T. Cross; J.R. Johnson; M.C. Baechler

1991-06-01T23:59:59.000Z

449

Alectinib Shows Potent Antitumor Activity against RET-Rearranged Non–Small Cell Lung Cancer  

Science Journals Connector (OSTI)

...was evaluated using the time-resolved fluorescence resonance energy transfer assay to examine each compound's ability to phosphorylate...residues are shown in stick form (C in yellow, white, and green; O in red; and N in blue). C, X-ray structure of alectinib...

Tatsushi Kodama; Toshiyuki Tsukaguchi; Yasuko Satoh; Miyuki Yoshida; Yoshiaki Watanabe; Osamu Kondoh; and Hiroshi Sakamoto

2014-12-01T23:59:59.000Z

450

Modulation of the c-Met/Hepatocyte Growth Factor Pathway in Small Cell Lung Cancer  

Science Journals Connector (OSTI)

...important for the function of the c-sis/platelet-derived growth...Triche, I. J., and Denny, C. I. A second Ewing's sarcoma translocation...E., Roussel, M. F., Denny, C. I., and Shapiro, D. N. A variant Ewing's sarcoma...

Gautam Maulik; Takashi Kijima; Patrick C. Ma; Sudip K. Ghosh; Jeffrey Lin; Geoffrey I. Shapiro; Erik Schaefer; Elena Tibaldi; Bruce E. Johnson; and Ravi Salgia

2002-02-01T23:59:59.000Z

451

WNT7a induces E-cadherin in lung cancer cells  

Science Journals Connector (OSTI)

...Li, E., Helfrich, B., Bunn, P., Roche, J., Brambilla, E., et al. ( 2000 ) Proc. Natl. Acad. Sci. USA 97, 12776 -12781. 11070089 9 Shigemitsu, K., Sekido, Y., Usami, N., Mori, S., Sato, M., Horio, Y., Hasegawa, Y...

Tatsuo Ohira; Robert M. Gemmill; Kevin Ferguson; Sophie Kusy; Joëlle Roche; Elisabeth Brambilla; Chan Zeng; Anna Baron; Lynne Bemis; Paul Erickson; Elizabeth Wilder; Anil Rustgi; Jan Kitajewski; Edward Gabrielson; Roy Bremnes; Wilbur Franklin; Harry A. Drabkin

2003-01-01T23:59:59.000Z

452

Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors  

Science Journals Connector (OSTI)

...modern cooking fuels (gas, electricity, or kerosene...modern cooking fuel (gas, electricity, or kerosene...which involve heating oil to high temperatures...for different types of oils used for cooking and exposure...case-control study from Missouri (OR 1.1; 95% CI 0...

Jonathan M. Samet; Erika Avila-Tang; Paolo Boffetta; Lindsay M. Hannan; Susan Olivo-Marston; Michael J. Thun; and Charles M. Rudin

2009-09-15T23:59:59.000Z

453

Fisetin modulates mitochondrial enzymes and apoptotic signals in benzo(a)pyrene-induced lung cancer  

Science Journals Connector (OSTI)

The present study was aimed to delineate in vivo mechanisms of orally administered fisetin with special reference to mitochondrial dysfunction in ... were alleviated when the mice were treated with fisetin (25 mg...

Nagaiya Ravichandran; Gopal Suresh…

2014-05-01T23:59:59.000Z

454

Cytochrome P450IIE1 Genetic Polymorphisms, Racial Variation, and Lung Cancer Risk  

Science Journals Connector (OSTI)

...homozygotes, the statistical power of the study is severely...those without), the power would be only 0.30...be needed to achieve a power of 0.80. In the Japanese...association of these tumors with car- cinogens such as N-nitrosamines...Formation of DNA adducts and water-soluble metabolites...

Shunji Kato; Peter G. Shields; Neil E. Caporaso; Robert N. Hoover; Benjamin F. Trump; Haruhiko Sugimura; Ainsley Weston; and Curtis C. Harris

1992-12-01T23:59:59.000Z

455

Uracil–DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed  

Science Journals Connector (OSTI)

...Repair 2008;7:1869-81. 46. Ivarie R .Thymine methyls and DNA-protein interactions.Nucleic Acids Res 1987;15:9975-83. 47. Nilsen H , Stamp G, Andersen S, Hrivnak G, Krokan HE, Lindahl T, et alGene-targeted mice lacking the Ung uracil-DNA...

Lachelle D. Weeks; Pingfu Fu; Stanton L. Gerson

2013-10-01T23:59:59.000Z

456

Plasma 7?-Hydroxycholesterol as a Possible Predictor of Lung Cancer Risk  

Science Journals Connector (OSTI)

...Berlin), 129: 169-176, 1997. 15 Boeing H., Korfmann A., Bergmann M. M...Jeckel A., Klipstein-Grobusch K., Boeing H. Measures of quality control in the...Bohlscheid-Thomas S., Hoting I., Boeing H., Wahrendorf J. Reproducibility and...

Jakob Linseisen; Günther Wolfram; Anthony B. Miller

2002-12-01T23:59:59.000Z

457

A DRD1 Polymorphism Predisposes to Lung Cancer among Those Exposed to Secondhand Smoke during Childhood  

Science Journals Connector (OSTI)

...initially identified and then evaluated for potential positioning within the seed region of a miRNA binding site using three web-based tools: Patrocles ( www.patrocles.org ), PolymiRTS ( http://compbio.uthsc.edu/miRSNP/ ), and SNPInfo...

Ana I. Robles; Ping Yang; Jin Jen; Andrew C. McClary; Kara Calhoun; Elise D. Bowman; Kirsi Vähäkangas; K. Leigh Greathouse; Yi Wang; Susan Olivo-Marston; Angela S. Wenzlaff; Bo Deng; Ann G. Schwartz; Bríd M. Ryan

2014-12-01T23:59:59.000Z

458

Systematic Evaluation of Genetic Variants in the Inflammation Pathway and Risk of Lung Cancer  

Science Journals Connector (OSTI)

...conditions were as follows: 94C for 1 min; 30 cycles of 94C for 1 min, 60C for 1 min, and...from a physician practice instead of the general population, but it is unlikely that control...Ohta K, Yamashita N, Tajima M, et al. Diesel exhaust particulate induces airway hyperresponsiveness...

Eric A. Engels; Xifeng Wu; Jian Gu; Qiong Dong; Jun Liu; and Margaret R. Spitz

2007-07-01T23:59:59.000Z

459

Beclin1-induced Autophagy Abrogates Radioresistance of Lung Cancer Cells by Suppressing Osteopontin  

Science Journals Connector (OSTI)

......all mammalian cell types by the mTOR inhibitor rapamycin.36) In this study, rapamycin...al (2008) Urocanic acid-modified chitosan-mediated PTEN delivery via aerosol...al (2008) Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy......

Seung-Hee Chang; Arash Minai-Tehrani; Ji-Young Shin; Sungjin Park; Ji-Eun Kim; Kyeong-Nam Yu; Seong-Ho Hong; Choong-Man Hong; Kee-Ho Lee; George R Beck; Jr; Myung-Haing Cho

2012-05-01T23:59:59.000Z

460

Lung Cancer Risk in Nonsmokers and GSTM1 and GSTT1 Genetic Polymorphism  

Science Journals Connector (OSTI)

...Anne-Marie Camus-Radon Fredrik Nyberg Wolfgang...Lang Paolo Boffetta International Agency for Research...carcinogens. We conducted an international collaborative study...Materials and Methods The project consisted of a case-control...Training Award from the International Agency for Research...

Núria Malats; Anne-Marie Camus-Radon; Fredrik Nyberg; Wolfgang Ahrens; Vali Constantinescu; Anush Mukeria; Simone Benhamou; Halina Batura-Gabryel; Irene Bruske-Hohlfeld; Lorenzo Simonato; Ana Menezes; Suzanne Lea; Matti Lang; and Paolo Boffetta

2000-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "lung cancer incidence" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Nitrated and Oxidized Plasma Proteins in Smokers and Lung Cancer Patients  

Science Journals Connector (OSTI)

...be addressed, at the International Agency for Research...the management of the project. S. Benhamou (Villejuif...Malats M., Camus-Radon A. M., Nyberg F...plasma proteins. | International Agency for Research...

Brigitte Pignatelli; Chun-Qi Li; Paolo Boffetta; Qiping Chen; Wolfgang Ahrens; Fredrik Nyberg; Anush Mukeria; Irene Bruske-Hohlfeld; Cristina Fortes; Vali Constantinescu; Harry Ischiropoulos; and Hiroshi Ohshima

2001-01-01T23:59:59.000Z

462

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer  

Science Journals Connector (OSTI)

... AFM218xe7 (T160), which is linked to DcR3 (likelihood score = 5.4), SHGC-36268 (T159), the nearest available marker which maps to ?500 kilobases from T160 ...

Robert M. Pitti; Scot A. Marsters; David A. Lawrence; Margaret Roy; Frank C. Kischkel; Patrick Dowd; Arthur Huang; Christopher J. Donahue; Steven W. Sherwood; Daryl T. Baldwin; Paul J. Godowski; William I. Wood; Austin L. Gurney; Kenneth J. Hillan; Robert L. Cohen; Audrey D. Goddard; David Botstein; Avi Ashkenazi

1998-12-17T23:59:59.000Z

463

Proteogenomic Analysis of Human Chromosome 9-Encoded Genes from Human Samples and Lung Cancer Tissues  

Science Journals Connector (OSTI)

Sugasawa, K.; Ng, J. M.; Masutani, C.; Maekawa, T.; Uchida, A.; van der Spek, P. J.; Eker, A. P.; Rademakers, S.; Visser, C.; Aboussekhra, A.; Wood, R. D.; Hanaoka, F.; Bootsma, D.; Hoeijmakers, J. H.Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity Mol. ... Sugasawa, Kaoru; Ng, Jessica M. Y.; Masutani, Chikahide; Maekawa, Takafumi; Uchida, Akio; van der Spek, Peter J.; Eker, Andre P. M.; Rademakers, Suzanne; Visser, Cecile; Aboussekhra, Abdelilah; Wood, Richard D.; Hanaoka, Fumio; Bootsma, Dirk; Hoeijmakers, Jan H. J. ...

Jung-Mo Ahn; Min-Sik Kim; Yong-In Kim; Seul-Ki Jeong; Hyoung-Joo Lee; Sun Hee Lee; Young-Ki Paik; Akhilesh Pandey; Je-Yoel Cho

2013-11-25T23:59:59.000Z

464

C-CAM1, a Candidate Tumor Suppressor Gene, Is Abnormally Expressed in Primary Lung Cancers  

Science Journals Connector (OSTI)

...We thank Drs. Shi Yong Sun, Jennifer Tseng, Xi Ming Tang, Se Jin Jang, and Yun W. Oh for useful discussion and You Hong Fan, Marivonne Rodriguez, Wei Ping Luo, and Ping Yue for technical assistance. 1 Hinoda Y., Neumaier...

Luo Wang; Sue Hwa Lin; Wei Guo Wu; Bonnie L. Kemp; Garrett L. Walsh; Waun Ki Hong; and Li Mao

2000-08-01T23:59:59.000Z

465

Portable stove intervention reduces lung cancer mortality risk in lifetime smoky coal users  

Science Journals Connector (OSTI)

...pattern that may be associated with household coal burning Howard D. Hosgood 1 William Pao...combustion, particularly from bituminous coal. To further explore the clinical and histological...all subjects with KRAS mutations burned coal indoors for heating and cooking, our findings...

H. Dean Hosgood; Min Shen; Robert Champan; Eric Chen; Tongzhang Zheng; Kyoung-mu Lee; Xingzhou He; Qing Lan

2008-05-01T23:59:59.000Z

466

ADAM8 as a Novel Serological and Histochemical Marker for Lung Cancer  

Science Journals Connector (OSTI)

...for 2 hours at room temperature. DMEM (0.75 mL...and/or targets for development of therapeutic agents...potential target for development of novel tools for...is homologous to a snake disintegrin, Reprolysin...potential role in tumor development or progression. In...

Nobuhisa Ishikawa; Yataro Daigo; Wataru Yasui; Kouki Inai; Hitoshi Nishimura; Eiju Tsuchiya; Nobuoki Kohno; and Yusuke Nakamura

2004-12-15T23:59:59.000Z

467

Bayesian Pharmacokinetically Guided Dosing of Paclitaxel in Patients with Non-Small Cell Lung Cancer  

Science Journals Connector (OSTI)

...ADP-ribose)polymerase. Yet, when applied together with TPA, they also...alone. The inhibitors were applied after dissolution in PBS...3-aminobenzamide (9). When we applied different inhibitors at concentrations...Promoters, pp. 291-301. Utrecht: NVU Science Press. 1984...

Milly E. de Jonge; H. J. G. Desirée van den Bongard; Alwin D. R. Huitema; Ron A. A. Mathôt; Hilde Rosing; Paul Baas; Nico van Zandwijk; Jos H. Beijnen; and Jan H. M. Schellens

2004-04-01T23:59:59.000Z

468

Inhalation exposure to ambient polycyclic aromatic hydrocarbons and lung cancer risk of Chinese population  

Science Journals Connector (OSTI)

...987 . 36 Zhang JF Smith KR ( 2007 ) Household air pollution from coal and biomass fuels...at a temperature of T0 and the active energy (a):0 OHk 0 0exp((1/1/))OH...relationship to emission sources in the Pan-Japan Sea countries. Atmospheric Environment...

Yanxu Zhang; Shu Tao; Huizhong Shen; Jianmin Ma

2009-01-01T23:59:59.000Z

469

Breast-Cancer Screening  

Science Journals Connector (OSTI)

....79 to 0.99) for death from breast cancer, the USPSTF previously recommended routine screening mammography for women in this age group. Since it had been argued that the benefit of screening women in their 40s could largely be attributed to the detection of cancers after the age of 50 years in women... This article reviews current recommendations for breast-cancer screening and the supporting evidence, including the controversy regarding mammographic screening of women in their 40s.

Warner E.

2011-09-15T23:59:59.000Z

470

Cancer Due to Prolonged Inflammation  

E-Print Network [OSTI]

Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

Lingampalli, Nithya

2013-01-01T23:59:59.000Z

471

Genetic susceptibility of cervical cancer.  

E-Print Network [OSTI]

??Cervical cancer is the third most common cancer in women worldwide. Lifetime risks for cervical cancer range from 0.4% in Israel to 5,3% in Colombia,… (more)

Zoodsma, Margreet

2005-01-01T23:59:59.000Z

472

Work Capacity, Thermal Responses and Lung Function: United Kingdom Studies in the I.B.P.  

Science Journals Connector (OSTI)

...1976 research-article Work Capacity, Thermal Responses and Lung Function: United Kingdom...and water, as shown by studies in the Sudan and Tanzania. Lung function of some seven...factors was examined. Work capacity, thermal responses and lung function: united kingdom...

1976-01-01T23:59:59.000Z

473

Oncogene-Mediated Human Lung Epithelial Cell Transformation Produces Adenocarcinoma Phenotypes In Vivo  

Science Journals Connector (OSTI)

...It has been challenging to engineer lung adenocarcinoma models...challenges facing the field is to engineer transformed lung epithelial...at 37C under a low oxygen environment (3% O2 and 5% CO2) in...It has been challenging to engineer lung adenocarcinoma models...

Ken Sasai; Taiko Sukezane; Emmy Yanagita; Harumi Nakagawa; Azusa Hotta; Tomoo Itoh; and Tsuyoshi Akagi

2011-04-01T23:59:59.000Z

474

Dose-Volume Histogram Parameters and Clinical Factors Associated With Pleural Effusion After Chemoradiotherapy in Esophageal Cancer Patients  

SciTech Connect (OSTI)

Purpose: To investigate the dose-volume histogram parameters and clinical factors as predictors of pleural effusion in esophageal cancer patients treated with concurrent chemoradiotherapy (CRT). Methods and Materials: Forty-three esophageal cancer patients treated with definitive CRT from January 2001 to March 2007 were reviewed retrospectively on the basis of the following criteria: pathologically confirmed esophageal cancer, available computed tomography scan for treatment planning, 6-month follow-up after CRT, and radiation dose {>=}50 Gy. Exclusion criteria were lung metastasis, malignant pleural effusion, and surgery. Mean heart dose, mean total lung dose, and percentages of heart or total lung volume receiving {>=}10-60 Gy (Heart-V{sub 10} to V{sub 60} and Lung-V{sub 10} to V{sub 60}, respectively) were analyzed in relation to pleural effusion. Results: The median follow-up time was 26.9 months (range, 6.7-70.2) after CRT. Of the 43 patients, 15 (35%) developed pleural effusion. By univariate analysis, mean heart dose, Heart-V{sub 10} to V{sub 60}, and Lung-V{sub 50} to V{sub 60} were significantly associated with pleural effusion. Poor performance status, primary tumor of the distal esophagus, and age {>=}65 years were significantly related with pleural effusion. Multivariate analysis identified Heart-V{sub 50} as the strongest predictive factor for pleural effusion (p = 0.01). Patients with Heart-V{sub 50} <20%, 20%{<=} Heart-V{sub 50} <40%, and Heart-V{sub 50} {>=}40% had 6%, 44%, and 64% of pleural effusion, respectively (p < 0.01). Conclusion: Heart-V{sub 50} is a useful parameter for assessing the risk of pleural effusion and should be reduced to avoid pleural effusion.

Shirai, Katsuyuki, E-mail: katu.shirai@gmail.com [Department of Radiation Oncology, Gunma Prefectural Cancer Center, Ota (Japan); Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi (Japan); Tamaki, Yoshio; Kitamoto, Yoshizumi [Department of Radiation Oncology, Gunma Prefectural Cancer Center, Ota (Japan); Murata, Kazutoshi; Satoh, Yumi [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi (Japan); Higuchi, Keiko [Department of Radiation Oncology, Gunma Prefectural Cancer Center, Ota (Japan); Nonaka, Tetsuo; Ishikawa, Hitoshi; Katoh, Hiroyuki; Takahashi, Takeo; Nakano, Takashi [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi (Japan)

2011-07-15T23:59:59.000Z

475

National Cancer Institute Thesaurus  

Science Journals Connector (OSTI)

The NCI Thesaurus is a comprehensive collection of terms relating ... clinical oncology, and cancer epidemiology. The NCI Thesaurus was conceived in the 1990s as a...

Prof. Mark A. Musen

2013-01-01T23:59:59.000Z

476

Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management  

Science Journals Connector (OSTI)

Epidemiologic and case control population based studies over the past few decades have identified diet as an important determinant of cancer risk. This evidence has kindled interest into research on bioactive food components and has till date resulted in the identification of many compounds with cancer preventive and therapeutic potential. Among such compounds has been fisetin (3,7,3?,4?-tetrahydroxyflavone), a flavonol and a member of the flavonoid polyphenols that also include quercetin, myricetin and kaempferol. Fisetin is commonly found in many fruits and vegetables such as apples, persimmons, grapes, kiwis, strawberries, onions and cucumbers. We evaluated the effects of fisetin against melanoma and cancers of the prostate, pancreas and the lungs. Using prostate and lung adenocarcinoma cells, we demonstrated that fisetin acts as a dual inhibitor of the PI3K/Akt and the mTOR pathways. This is a significant finding considering the fact that mTOR is phosphorylated and its activation is more frequent in tumors with overexpression of PI3K/Akt. Dual inhibitors of PI3K/Akt and mTOR signaling have been suggested as valuable agents for treating such cancers. Here, we summarize our findings on the dietary flavonoid fisetin and its effects on cancer with particular focus on prostate cancer. Our observations and findings from other laboratories suggest that fisetin could be a useful chemotherapeutic agent that could be used either alone or as an adjuvant with conventional chemotherapeutic drugs for the management of prostate and other cancers.

Vaqar Mustafa Adhami; Deeba Nadeem Syed; Naghma Khan; Hasan Mukhtar

2012-01-01T23:59:59.000Z

477

Cancer and the medicare disabled.  

E-Print Network [OSTI]

??This dissertation examines relationships between cancer in working-age adults and enrollment in Medicare due disability. We examine whether cancer diagnosis and treatments affect enrollment in… (more)

Habermann, Elizabeth Anne

2008-01-01T23:59:59.000Z

478

Childhood leukaemia incidence below the age of 5 years near French nuclear power plants  

E-Print Network [OSTI]

Childhood leukaemia incidence below the age of 5 years near French nuclear power plants D Laurier 1 living in the vicinity of nuclear power plants in Germany. We present herein results about the incidence of childhood leukaemia in the vicinity of nuclear power plants in France for the same age range. These results

Paris-Sud XI, Université de

479

The low energy ion assisted control of interfacial structure: ion incident angle eects  

E-Print Network [OSTI]

The low energy ion assisted control of interfacial structure: ion incident angle eects X.W. Zhou *, H.N.G. Wadley Department of Materials Science and Engineering, School of Engineering and Applied atomistic modeling of normal incident angle ion impacts with model Ni/Cu/Ni multilayer surfaces have

Wadley, Ha