Sample records for link biological systems

  1. Systems Biology. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biology. Systems Biology. Abstract: The biology revolution over the last 50 years has been driven by the ascendancy of molecular biology. This was enthusiastically embraced by most...

  2. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genomics and Systems Biology Genomics and Systems Biology Los Alamos scientists perform research in functional genomics and structural genomics, and applications for such work...

  3. Gelation in Multiple Link Systems

    E-Print Network [OSTI]

    Kazumi Suematsu

    2005-10-24T23:59:59.000Z

    Within the framework of the random distribution assumption of cyclic bonds, the theory of gelation is extended to mixing systems of the R-Ag + R-Bf-g model, which is expected to have wider application such as micell formations in biological systems. We derive the gel point expression of this biologically interesting new system.

  4. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genomics and Systems Biology LANL leads the world in computational finishing of microbial genomes Read caption + In 2013, Los Alamos scientist Richard Sayre and his team...

  5. Genomics-Bioinformatics Day: "Bioinformatics, Computational Biology, Systems Biology & Mathematical

    E-Print Network [OSTI]

    Goldschmidt, Christina

    3rd Genomics-Bioinformatics Day: "Bioinformatics, Computational Biology, Systems Biology on "Bioinformatics, Computational Biology, Systems Biology & Mathematical Biology: Their Relationship". Genomics, Bioinformatics, Computational Biology have a tremendous appeal and these fields have originated or grown

  6. 7th Annual Systems Biology Symposium: Systems Biology and Engineering

    SciTech Connect (OSTI)

    Galitski, Timothy P.

    2008-04-01T23:59:59.000Z

    Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology has been hosted by the Institute for Systems Biology in Seattle, Washington, since 2002. The annual two-day event gathers the most influential researchers transforming biology into an integrative discipline investingating complex systems. Engineering and application of new technology is a central element of systems biology. Genome-scale, or very small-scale, biological questions drive the enigneering of new technologies, which enable new modes of experimentation and computational analysis, leading to new biological insights and questions. Concepts and analytical methods in engineering are now finding direct applications in biology. Therefore, the 2008 Symposium, funded in partnership with the Department of Energy, featured global leaders in "Systems Biology and Engineering."

  7. Systems Biology | Clean Energy | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of interdisciplinary scientists. Additional systems biology resources Research Highlights Media Mentions Publications Newsletters Biosciences Division Recent news releases 11...

  8. Systems Biology | More Science | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  9. Biological Systems Facilities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    encompasses the areas of priority pathogen detection, extremophile biology and genomics, biohydrometallurgy, biomass conversion, coal bioprocessing, biodegradation...

  10. Department of Systems Biology & Bioinformatics

    E-Print Network [OSTI]

    Rostock, Universität

    Department of Systems Biology & Bioinformatics Faculty of Computer Sciences & Electrical, comparability and fairness. Practical Aspects and Soft Skills Technical Achievement Background understanding

  11. Introduction to Bioinformatics A Systems Biology Approach

    E-Print Network [OSTI]

    Rocha, Luis

    Introduction to Bioinformatics A Systems Biology Approach Luis M. Rocha Complex Systems Modeling Computational Biology to Bioinformatics Course Layout: March 11-15, 2002 #12;P Systems Biology P Synthetic, Multi- Disciplinary Approach

  12. Modular design of biological systems

    E-Print Network [OSTI]

    Norville, Julie Erin, 1980-

    2012-01-01T23:59:59.000Z

    The focus of my research is the development of technology for building compound biological systems from simpler pieces. I designed BioScaffold parts, a family of variable regions that can be inserted into a DNA sequence ...

  13. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  14. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField8,Dist.Newof EnergyFundingGeneGenome Engineering withfor

  15. Systems biology approach to bioremediation

    SciTech Connect (OSTI)

    Chakraborty, R.; Wu, C. H.; Hazen, T. C.

    2012-01-01T23:59:59.000Z

    Bioremediation has historically been approached as a ?black box? in terms of our fundamental understanding. Thus it succeeds and fails, seldom without a complete understanding of why. Systems biology is an integrated research approach to study complex biological systems, by investigating interactions and networks at the molecular, cellular, community, and ecosystem level. The knowledge of these interactions within individual components is fundamental to understanding the dynamics of the ecosystem under investigation. Understanding and modeling functional microbial community structure and stress responses in environments at all levels have tremendous implications for our fundamental understanding of hydrobiogeochemical processes and the potential for making bioremediation breakthroughs and illuminating the ?black box?.

  16. Biologic

    E-Print Network [OSTI]

    Louis H. Kauffman

    2002-04-03T23:59:59.000Z

    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers >protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  17. Systems biology of Microbial Communities

    SciTech Connect (OSTI)

    Navid, A; Ghim, C; Fenley, A; Yoon, S; Lee, S; Almaas, E

    2008-04-11T23:59:59.000Z

    Microbes exist naturally in a wide range of environments, spanning the extremes of high acidity and high temperature to soil and the ocean, in communities where their interactions are significant. We present a practical discussion of three different approaches for modeling microbial communities: rate equations, individual-based modeling, and population dynamics. We illustrate the approaches with detailed examples. Each approach is best fit to different levels of system representation, and they have different needs for detailed biological input. Thus, this set of approaches is able to address the operation and function of microbial communities on a wide range of organizational levels.

  18. Experiment design for systems biology

    E-Print Network [OSTI]

    Apgar, Joshua Farley

    2009-01-01T23:59:59.000Z

    Mechanism-based chemical kinetic models are increasingly being used to describe biological signaling. Such models serve to encapsulate current understanding of pathways and to enable insight into complex biological processes. ...

  19. Systems Biology | More Science | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  20. Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology

    E-Print Network [OSTI]

    Ussery, David W.

    Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology Visualisation of Large Amounts of Data Dave Ussery 27 February, 2008 #12;Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology #12;Comparative Microbial Genomics group

  1. Method of measurement in biological systems

    DOE Patents [OSTI]

    Turteltaub, K.W.; Vogel, J.S.; Felton, J.S.; Gledhill, B.L.: Davis, J.C.; Stanker, L.H.

    1993-05-11T23:59:59.000Z

    A method is disclosed of quantifying molecules in biological substances, comprising: selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere; preparing a long-lived radioisotope labeled reactive chemical specie; administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system; allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host; isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources; converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation; and measuring the radioisotope concentration in the material by means of direct isotopic counting.

  2. Complexity and Systems Biology of Microbial Biofuels

    E-Print Network [OSTI]

    Rand, David

    Complexity and Systems Biology of Microbial Biofuels 20-24 June 2011 (All and issues Theme: Biofuel systems and issues (Chair: Nigel Burroughs) 13 (Bielefeld) Biofuels from algae- challenges for industrial levels

  3. Controlling biological systems: the lactose regulation system of Escherichia coli

    E-Print Network [OSTI]

    Pappas, George J.

    Controlling biological systems: the lactose regulation system of Escherichia coli A. Agung Julius hybrid model of the lactose regulation system of E. coli bacteria that capture important phenomena which In this paper we present a framework that consists of modeling, abstraction and control of a biological system

  4. A Systems Biology Approach to Infectious Disease Research: Innovating...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm. A Systems Biology Approach to Infectious Disease Research: Innovating the...

  5. Comparative systems biology across an evolutionary gradient within...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systems biology across an evolutionary gradient within the Shewanella genus . Comparative systems biology across an evolutionary gradient within the Shewanella genus . Abstract: To...

  6. SPECIAL ISSUE ON SYSTEMS BIOLOGY, JANUARY 2008 51 Stochastic Modeling and Control of Biological

    E-Print Network [OSTI]

    Pappas, George J.

    of modeling, abstraction, and control of a biological system, namely, the lactose regulation systemSPECIAL ISSUE ON SYSTEMS BIOLOGY, JANUARY 2008 51 Stochastic Modeling and Control of Biological for stochastic modeling, model abstraction, and controller design for a biological system. The first half

  7. New Approaches to Improved Animal Health: Systems Biology and Modeling of Real Interactions of Pathogens and their Hosts

    E-Print Network [OSTI]

    decade or sousing comprehensive systems biology approaches linking genomics, proteomics, bioinformatics of computational systems biology analysis of host:pathogen interactions (the interactome) as a tool for enhanced are using computational systems biology methods to create interactome models of the actual host responses

  8. Method of measurement in biological systems

    DOE Patents [OSTI]

    Turteltaub, K.W.; Vogel, J.S.; Felton, J.S.; Gledhill, B.L.; Davis, J.C.

    1994-12-27T23:59:59.000Z

    Disclosed is a method of quantifying molecules in biological substances comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system, d. allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host, e. isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources, f. converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in the material by means of direct isotopic counting. 5 figures.

  9. Systems Biology | More Science | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  10. Systems Biology | Clean Energy | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solid ...SuccessSurprisingSynchrotronsPlasma Physics Bioenergy

  11. Document creation, linking, and maintenance system

    DOE Patents [OSTI]

    Claghorn, Ronald (Pasco, WA)

    2011-02-15T23:59:59.000Z

    A document creation and citation system designed to maintain a database of reference documents. The content of a selected document may be automatically scanned and indexed by the system. The selected documents may also be manually indexed by a user prior to the upload. The indexed documents may be uploaded and stored within a database for later use. The system allows a user to generate new documents by selecting content within the reference documents stored within the database and inserting the selected content into a new document. The system allows the user to customize and augment the content of the new document. The system also generates citations to the selected content retrieved from the reference documents. The citations may be inserted into the new document in the appropriate location and format, as directed by the user. The new document may be uploaded into the database and included with the other reference documents. The system also maintains the database of reference documents so that when changes are made to a reference document, the author of a document referencing the changed document will be alerted to make appropriate changes to his document. The system also allows visual comparison of documents so that the user may see differences in the text of the documents.

  12. Biological Control of Music Systems

    E-Print Network [OSTI]

    Miranda, Eduardo Reck

    ? Sonification for Auditory Display Some sort of compositional system Tenney's Meta-Hodos is current source Rock-Music #12;Music for Solo Performer Performed November 14, 1999 Used "Automates Ki" system February 2006 in TheUpgrade! Human multi-band EEG 8-channel sound reproduction Hybrid physical/source

  13. Systems Biology Group Decision Making

    E-Print Network [OSTI]

    entities (e.g., molecular, cellular, organism, ecological) #12;OHIO STATE T . H . E UNIVERSITY Systems/analysis of perception, attention, choice, learning, optimality,... #12;OHIO STATE T . H . E UNIVERSITY Group decision making, evolution and ecology Current work: Modeling/analysis of coordinated motion, foraging, choice

  14. Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  15. Systems Modeling for Prognostic Cancer Biology

    E-Print Network [OSTI]

    Maccabe, Barney

    goal of this research is the development of personalized treatments in cancer, based on the genomic and treatment. A major challenge in contemporary cancer diagnosis and treatment is the development Systems Modeling for Prognostic Cancer Biology Xuefei Wang1 , BaiLian Li2 , Cheryl L. Willman

  16. Incorporating Optics into a Coupled Physical-Biological Forecasting System in the Monterey Bay

    E-Print Network [OSTI]

    Boss, Emmanuel S.

    Incorporating Optics into a Coupled Physical-Biological Forecasting System in the Monterey Bay Fei://www.marine.maine.edu/~eboss/index.html http://ourocean.jpl.nasa.gov/ LONG-TERM GOALS Modeling and predicting ocean optical properties for coastal waters requires linking optical properties with the physical, chemical, and biological processes

  17. Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your HomeLatestCenter (LMI-EFRC) -Choices toLeeLinearb A By A

  18. KPFM and PFM of Biological Systems

    SciTech Connect (OSTI)

    Rodriguez, Brian [University College, Dublin; Kalinin, Sergei V [ORNL

    2011-01-01T23:59:59.000Z

    Surface potentials and electrostatic interactions in biological systems are a key element of cellular regulation and interaction. Examples include cardiac and muscular activity, voltage-gated ion channels, protein folding and assembly, and electroactive cells and electrotransduction. The coupling between electrical, mechanical, and chemical signals and responses in cellular systems necessitates the development of tools capable of measuring the distribution of charged species, surface potentials, and mechanical responses to applied electrical stimuli and vice versa, ultimately under physiological conditions. In this chapter, applications of voltage-modulated atomic force microscopy (AFM) methods including Kelvin probe force microscopy (KPFM) and piezoresponse force microscopy (PFM) to biological systems are discussed. KPFM is a force-sensitive non-contact or intermittent-contact mode AFM technique that allows electrostatic interactions and surface potentials to be addressed. Beyond long-range electrostatic interactions, the application of bias can lead to a mechanical response, e.g., due to linear piezoelectric coupling in polar biopolymers or via more complex electrotransduction and redox pathways in other biosystems. The use and development of PFM, based on direct electromechanical detection, to biological systems will also be addressed. The similarities and limitations of measuring surface potentials and electromechanical coupling in solution will be outlined.

  19. 6th Annual Systems Biology Symposium: Systems Biology and the Environment

    SciTech Connect (OSTI)

    Galitski, Timothy, P.

    2007-04-01T23:59:59.000Z

    Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology is an annual two-day event gathering the most influential researchers transforming biology into an integrative discipline investigating complex systems. In recognition of the fundamental similarity between the scientific problems addressed in environmental science and systems biology studies at the molecular, cellular, and organismal levels, the 2007 Symposium featured global leaders in “Systems Biology and the Environment.” The objective of the 2007 “Systems Biology and the Environment” International Symposium was to stimulate interdisciplinary thinking and research that spans systems biology and environmental science. This Symposium was well aligned with the DOE’s Genomics:GTL program efforts to achieve scientific objectives for each of the three DOE missions: • Develop biofuels as a major secure energy source for this century, • Develop biological solutions for intractable environmental problems, and • Understand biosystems’ climate impacts and assess sequestration strategies Our scientific program highlighted world-class research exemplifying these priorities. The Symposium featured 45 minute lectures from 12 researchers including: Penny/Sallie Chisholm of MIT gave the keynote address “Tiny Cells, Global Impact: What Prochlorococcus Can Teach Us About Systems Biology”, plus Jim Fredrickson of PNNL, Nitin Baliga of ISB, Steve Briggs of UCSD, David Cox of Perlegen Sciences, Antoine Danchin of Institut Pasteur, John Delaney of the U of Washington, John Groopman of Johns Hopkins, Ben Kerr of the U of Washington, Steve Koonin of BP, Elliott Meyerowitz of Caltech, and Ed Rubin of LBNL. The 2007 Symposium promoted DOE’s three mission areas among scientists from multiple disciplines representing academia, non-profit research institutions, and the private sector. As in all previous Symposia, we had excellent attendance of participants representing 20-30 academic or research-oriented facilities along with 25-30 private corporations from 5-10 countries. To broaden the audience for the Symposium and ensure the continued accessibility of the presentations, we made the presentation videos available afterward on the ISB’s website.

  20. Complex biological and bio-inspired systems

    SciTech Connect (OSTI)

    Ecke, Robert E [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    The understanding and characterization ofthe fundamental processes of the function of biological systems underpins many of the important challenges facing American society, from the pathology of infectious disease and the efficacy ofvaccines, to the development of materials that mimic biological functionality and deliver exceptional and novel structural and dynamic properties. These problems are fundamentally complex, involving many interacting components and poorly understood bio-chemical kinetics. We use the basic science of statistical physics, kinetic theory, cellular bio-chemistry, soft-matter physics, and information science to develop cell level models and explore the use ofbiomimetic materials. This project seeks to determine how cell level processes, such as response to mechanical stresses, chemical constituents and related gradients, and other cell signaling mechanisms, integrate and combine to create a functioning organism. The research focuses on the basic physical processes that take place at different levels ofthe biological organism: the basic role of molecular and chemical interactions are investigated, the dynamics of the DNA-molecule and its phylogenetic role are examined and the regulatory networks of complex biochemical processes are modeled. These efforts may lead to early warning algorithms ofpathogen outbreaks, new bio-sensors to detect hazards from pathomic viruses to chemical contaminants. Other potential applications include the development of efficient bio-fuel alternative-energy processes and the exploration ofnovel materials for energy usages. Finally, we use the notion of 'coarse-graining,' which is a method for averaging over less important degrees of freedom to develop computational models to predict cell function and systems-level response to disease, chemical stress, or biological pathomic agents. This project supports Energy Security, Threat Reduction, and the missions of the DOE Office of Science through its efforts to accurately model biological systems at the molecular and cellular level. The project's impact encompasses applications to biofuels, to novel sensors and to materials with broad use for energy or threat reduction. The broad, interdisciplinary approach of CNLS offers the unparalleled strength of combining science backgrounds and expertise -a unique and important asset in attacking the complex science of biological organisms. This approach also allows crossfertilization, with concepts and techniques transferring across field boundaries.

  1. High performance control of harmonic instability from HVDC link system

    SciTech Connect (OSTI)

    Min, W.K.; Yoo, M.H. [Korea Electric Power Research Inst., Taejeon (Korea, Republic of)

    1995-12-31T23:59:59.000Z

    This paper investigates the usefulness of novel control method for HVDC link system which suffers from severe condition of low order harmonic. This control scheme is used the feedforward control method which is directly controlled dc current at dc link system. The studies of this paper are aimed to improving the dynamic response of HVdc link system in disturbances such as faults. To achieve those objectives, digital time domain simulations are employed by the electro magnetic transient program for dc system (EMTDC). This method results in stable recovery from faults at both rectifier and inverter terminal busbars for a HVdc system that is inherently unstable. It has been found to be robust and control performance has been enhanced.

  2. Reliability assessment of autonomous power systems incorporating HVDC interconnection links

    SciTech Connect (OSTI)

    Dialynas, E.N.; Koskolos, N.C. [National Technical Univ., Athens (Greece). Dept. of Electrical and Computer Engineering] [National Technical Univ., Athens (Greece). Dept. of Electrical and Computer Engineering; Agoris, D. [Public Power Corp., Athens (Greece)] [Public Power Corp., Athens (Greece)

    1996-01-01T23:59:59.000Z

    The objective of this paper is to present an improved computational method for the overall reliability assessment of autonomous power systems that may or may not contain HVdc interconnection links. This is a hybrid method based on a Monte-Carlo simulation sequential approach which incorporates an analytical approach for the reliability modeling of the HVdc transmission links. The developed models and techniques have been implemented into a computer program that can be used to simulate the operational practices and characteristics of the overall system under study efficiently and realistically. A set of reliability indices are calculated for each load-point of interest and the entire system while a set of additional indices is calculated for quantifying the reliability performance of the interconnection links under the specified operating requirements. The analysis of a practical system is also included for a number of studies representing its various operating and design characteristics.

  3. AN INTEGRATED BIOLOGICAL CONTROL SYSTEM AT HANFORD

    SciTech Connect (OSTI)

    JOHNSON AR; CAUDILL JG; GIDDINGS RF; RODRIGUEZ JM; ROOS RC; WILDE JW

    2010-02-11T23:59:59.000Z

    In 1999 an integrated biological control system was instituted at the U.S. Department of Energy's Hanford Site. Successes and changes to the program needed to be communicated to a large and diverse mix of organizations and individuals. Efforts at communication are directed toward the following: Hanford Contractors (Liquid or Tank Waste, Solid Waste, Environmental Restoration, Science and Technology, Site Infrastructure), General Hanford Employees, and Hanford Advisory Board (Native American Tribes, Environmental Groups, Local Citizens, Washington State and Oregon State regulatory agencies). Communication was done through direct interface meetings, individual communication, where appropriate, and broadly sharing program reports. The objectives of the communication efforts was to have the program well coordinated with Hanford contractors, and to have the program understood well enough that all stakeholders would have confidence in the work performed by the program to reduce or elimated spread of radioactive contamination by biotic vectors. Communication of successes and changes to an integrated biological control system instituted in 1999 at the Department of Energy's Hanford Site have required regular interfaces with not only a diverse group of Hanford contractors (i.e., those responsible for liquid or tank waste, solid wastes, environmental restoration, science and technology, and site infrastructure), and general Hanford employees, but also with a consortium of designated stake holders organized as the Hanford Advisory Board (i.e., Native American tribes, various environmental groups, local citizens, Washington state and Oregon regulatory agencies, etc.). Direct interface meetings, individual communication where appropriate, and transparency of the biological control program were the methods and outcome of this effort.

  4. Biological Systems for Hydrogen Photoproduction (Presentation)

    SciTech Connect (OSTI)

    Ghirardi, M. L.

    2012-05-01T23:59:59.000Z

    This presentation summarizes NREL biological systems for hydrogen photoproduction work for the DOE Hydrogen and Fuel Cells Program Annual Merit Review and Peer Evaluation Meeting, May 14-18, 2012. General goal is develop photobiological systems for large-scale, low cost and efficient H{sub 2} production from water (barriers AH, AI and AJ). Specific tasks are: (1) Address the O{sub 2} sensitivity of hydrogenases that prevent continuity of H{sub 2} photoproduction under aerobic, high solar-to-hydrogen (STH) light conversion efficiency conditions; and (2) Utilize a limited STH H{sub 2}-producing method (sulfur deprivation) as a platform to address or test other factors limiting commercial algal H{sub 2} photoproduction, including low rates due to biochemical and engineering mechanisms.

  5. Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  6. Stochastic processes in biological systems : selected problems

    E-Print Network [OSTI]

    Artomov, Maksym

    2010-01-01T23:59:59.000Z

    Majority of biological processes can not be described deterministically. Multple levels of regulation contribute to the noise in the observable properties of the cells: fluctuations are ubiquitous in biological networks ...

  7. The Evolutionary Systems Biology Team Synthetic Biology/Citizen Science Post-doctoral position

    E-Print Network [OSTI]

    The Evolutionary Systems Biology Team Synthetic Biology/Citizen Science Post-doctoral position We in citizen science projects.The post-doc will join the extended CRI lab that includes synthetic and systems-sourcing, DIY approaches and gamification as part of a new European- funded project, Citizen CyberLab - a three

  8. Genomics and Systems Biology of Tuberculosis (2009 JGI User Meeting)

    ScienceCinema (OSTI)

    Galagan, James

    2011-04-25T23:59:59.000Z

    James Galagan from the Broad Institute spoke about the "Genomics and Systems Biology of TB" on March 26, 2009 during the 4th Annual User Meeting

  9. Linking Automated Data Analysis and Visualization with Applications in Developmental Biology and High-Energy Physics

    SciTech Connect (OSTI)

    Ruebel, Oliver

    2009-12-01T23:59:59.000Z

    Knowledge discovery from large and complex collections of today's scientific datasets is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the increasing number of data dimensions and data objects is presenting tremendous challenges for data analysis and effective data exploration methods and tools. Researchers are overwhelmed with data and standard tools are often insufficient to enable effective data analysis and knowledge discovery. The main objective of this thesis is to provide important new capabilities to accelerate scientific knowledge discovery form large, complex, and multivariate scientific data. The research covered in this thesis addresses these scientific challenges using a combination of scientific visualization, information visualization, automated data analysis, and other enabling technologies, such as efficient data management. The effectiveness of the proposed analysis methods is demonstrated via applications in two distinct scientific research fields, namely developmental biology and high-energy physics.Advances in microscopy, image analysis, and embryo registration enable for the first time measurement of gene expression at cellular resolution for entire organisms. Analysis of high-dimensional spatial gene expression datasets is a challenging task. By integrating data clustering and visualization, analysis of complex, time-varying, spatial gene expression patterns and their formation becomes possible. The analysis framework MATLAB and the visualization have been integrated, making advanced analysis tools accessible to biologist and enabling bioinformatic researchers to directly integrate their analysis with the visualization. Laser wakefield particle accelerators (LWFAs) promise to be a new compact source of high-energy particles and radiation, with wide applications ranging from medicine to physics. To gain insight into the complex physical processes of particle acceleration, physicists model LWFAs computationally. The datasets produced by LWFA simulations are (i) extremely large, (ii) of varying spatial and temporal resolution, (iii) heterogeneous, and (iv) high-dimensional, making analysis and knowledge discovery from complex LWFA simulation data a challenging task. To address these challenges this thesis describes the integration of the visualization system VisIt and the state-of-the-art index/query system FastBit, enabling interactive visual exploration of extremely large three-dimensional particle datasets. Researchers are especially interested in beams of high-energy particles formed during the course of a simulation. This thesis describes novel methods for automatic detection and analysis of particle beams enabling a more accurate and efficient data analysis process. By integrating these automated analysis methods with visualization, this research enables more accurate, efficient, and effective analysis of LWFA simulation data than previously possible.

  10. Why Are Computational Neuroscience and Systems Biology So Separate?

    E-Print Network [OSTI]

    De Schutter, Erik

    . Several examples are given, covering sociological, soft- ware technical, and methodological aspectsReview Why Are Computational Neuroscience and Systems Biology So Separate? Erik De Schutter1,2 * 1, there is surprisingly little interaction between the computational neuroscience and the systems biology research

  11. Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology,TechnicalUniversityofDenmark

    E-Print Network [OSTI]

    Ussery, David W.

    Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology,TechnicalUniversityofDenmark E. coli pangenomics - or - How to compare hundreds of E. coli genomes Fuzzy Dave Ussery Ullevĺl Universitetssykehus Oslo, Norway Wednesday, 10 December, 2008 #12;Comparative Microbial Genomics group Centerfor

  12. Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology,TechnicalUniversityofDenmark

    E-Print Network [OSTI]

    Ussery, David W.

    Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology,TechnicalUniversityofDenmark Burkholderia Pan-genomics Dave Ussery Max Planck Institut fur Terrestrial Microbiology Marburg, Germany 26 May, 2008 - or - What can we learn from more than 50 sequenced genomes? #12;Comparative Microbial Genomics

  13. Alternative Design Concepts for Multi-Circuit HTS Link Systems

    E-Print Network [OSTI]

    Ballarino, A

    2011-01-01T23:59:59.000Z

    Superconducting cables for power transmission usually contain two conductors for DC application, or three conductors for AC, with high voltage insulation. In contrast, for some applications related to accelerators it is convenient to transfer high currents via superconducting links feeding a number of circuits at relatively low voltage, of the order of a kilovolt, over distances of up to a few hundred meters. For power transmission applications based on cooling via sub-cooled liquid nitrogen, suitable HTS conductors are only available in the form of tape, and a multi-layer variant can be envisaged for the multi-circuit links. However, where cooling to temperatures of the order of 20 K is feasible, MgB2 conductor, available in the form of both tape and wire, can also be envisaged and in the latter case used to assemble round cables. There are, therefore, two distinct topologies - based on the use of wires or tapes - that can be envisaged for use in applications to multi-circuit link systems. In this paper the ...

  14. MONOTONE INPUT/OUTPUT SYSTEMS, AND APPLICATIONS TO BIOLOGICAL SYSTEMS

    E-Print Network [OSTI]

    Enciso, Germán

    . iii #12;Preface: From Tycho Brahe To Microarrays How does mathematics fit into modern biology research

  15. Biological Development model for the Design of Robust Digital System

    E-Print Network [OSTI]

    Fernandez, Thomas

    Biological Development model for the Design of Robust Digital System Heng Liu Doctor of Philosophy and Keywords i Abstract This thesis presents a biologically-inspired developmental model for the design. The methods presented have been applied to produce a self-repairing two bit multiplier and an autonomous robot

  16. The common ground of genomics and systems biology

    E-Print Network [OSTI]

    Conesa, Ana; Mortazavi, Ali

    2014-01-01T23:59:59.000Z

    8/S2. Authors’ details Genomics of Gene Expression Lab,systems biology. Annu Rev. Genomics Hum. Genet 2001, 2:343-projection strategies. Genomics 2008, 92(6):373-83. 31.

  17. Optimal control for biological movement systems

    E-Print Network [OSTI]

    Li, Weiwei

    2006-01-01T23:59:59.000Z

    Kalman. When is a linear control system optimal? Journal ofOptimal stationary control of linear systems with control-J. Mclane. Optimal stochastic control of linear systems with

  18. Biological optimization systems for enhancing photosynthetic efficiency and methods of use

    DOE Patents [OSTI]

    Hunt, Ryan W; Chinnasamy, Senthil; Das, Keshav C; Rolim de Mattos, Erico

    2014-02-25T23:59:59.000Z

    The present disclosure relates to biological optimization systems for enhancing photosynthetic efficiency and methods of use.

  19. Systems biology: the `new biotechnology' Editorial overview

    E-Print Network [OSTI]

    for sustainable production of fuels, chemicals and pharmaceuticals and for the identification of novel biomarkers science research, as this approach to study living systems is applied for: firstly, developing novel cell factories that can be used for sustainable production of fuels, chemicals and materials; secondly, gaining

  20. Request for Travel Funds for Systems Radiation Biology Workshop

    SciTech Connect (OSTI)

    Barcellos-Hoff, Mary Helen [NYU School of Medicine

    2014-03-22T23:59:59.000Z

    The 3rd International Systems Radiation Biology Workshop brought together the major European, US and Japanese research programs on radiation risk as well as selected experts representing systems biological approaches to discuss how the new methodologies could be best exploited for low dose research. A significant part of the workshop was devoted to discussions organised as breakout group sessions. To facilitate discussions number of participants was limited to 60 persons. To achieve the goals of this symposium in this international conference, support from DOE is vital. Hence, this proposal requested support in the amount of $15,000 to cover the travel expenses of international experts and radiation biology scientists from the United States. This supporting mechanism was clearly identified to the selected US participants as a conference support award from the DOE (See attached PDF). The workshop was an outstanding opportunity to strengthen interactions between leading experts in the emerging areas of radiation sciences, and will also provide opportunities for younger scientists to meet with experts and discuss their results. This workshop was designed to endorse active engagement in international collaboration. A major objective of this conference was to effectively communicate research results, in order to ensure that current thinking reflects sound science of radiation biology. Further, this international event addressed the use and success of scientific initiatives in radiation biology for policymakers, standard-setters, and the general public.

  1. Navigation Links Biology News

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    acids or proteins, into a cell to change its properties.) However, because bulk electroporation applies for high-speed nanopatterning of proteins and nanoparticles for drug delivery studies. The new single is proving to be extremely robust and multi-functional. Researchers have used the NFP-E chip to transfect He

  2. Review Article Aluminum-Induced Entropy in Biological Systems

    E-Print Network [OSTI]

    Seneff, Stephanie

    Review Article Aluminum-Induced Entropy in Biological Systems: Implications for Neurological years, mining, smelting, and refining of aluminum (Al) in various forms have increasingly exposed living of the Al toxicants to which we are being exposed. 1. Introduction Aluminum (Al) is the most common metal

  3. Enabling a Systems Biology Knowledgebase with Gaggle and Firegoose

    SciTech Connect (OSTI)

    Baliga, Nitin S. [Institute for Systems Biology

    2014-12-12T23:59:59.000Z

    The overall goal of this project was to extend the existing Gaggle and Firegoose systems to develop an open-source technology that runs over the web and links desktop applications with many databases and software applications. This technology would enable researchers to incorporate workflows for data analysis that can be executed from this interface to other online applications. The four specific aims were to (1) provide one-click mapping of genes, proteins, and complexes across databases and species; (2) enable multiple simultaneous workflows; (3) expand sophisticated data analysis for online resources; and enhance open-source development of the Gaggle-Firegoose infrastructure. Gaggle is an open-source Java software system that integrates existing bioinformatics programs and data sources into a user-friendly, extensible environment to allow interactive exploration, visualization, and analysis of systems biology data. Firegoose is an extension to the Mozilla Firefox web browser that enables data transfer between websites and desktop tools including Gaggle. In the last phase of this funding period, we have made substantial progress on development and application of the Gaggle integration framework. We implemented the workspace to the Network Portal. Users can capture data from Firegoose and save them to the workspace. Users can create workflows to start multiple software components programmatically and pass data between them. Results of analysis can be saved to the cloud so that they can be easily restored on any machine. We also developed the Gaggle Chrome Goose, a plugin for the Google Chrome browser in tandem with an opencpu server in the Amazon EC2 cloud. This allows users to interactively perform data analysis on a single web page using the R packages deployed on the opencpu server. The cloud-based framework facilitates collaboration between researchers from multiple organizations. We have made a number of enhancements to the cmonkey2 application to enable and improve the integration within different environments, and we have created a new tools pipeline for generating EGRIN2 models in a largely automated way.

  4. Systems Biology Knowledgebase for a New Era in Biology A Genomics:GTL Report from the May 2008 Workshop

    SciTech Connect (OSTI)

    Gregurick, S.; Fredrickson, J. K.; Stevens, R.

    2009-03-01T23:59:59.000Z

    Biology has entered a systems-science era with the goal to establish a predictive understanding of the mechanisms of cellular function and the interactions of biological systems with their environment and with each other. Vast amounts of data on the composition, physiology, and function of complex biological systems and their natural environments are emerging from new analytical technologies. Effectively exploiting these data requires developing a new generation of capabilities for analyzing and managing the information. By revealing the core principles and processes conserved in collective genomes across all biology and by enabling insights into the interplay between an organism's genotype and its environment, systems biology will allow scientific breakthroughs in our ability to project behaviors of natural systems and to manipulate and engineer managed systems. These breakthroughs will benefit Department of Energy (DOE) missions in energy security, climate protection, and environmental remediation.

  5. Biological Computation as the Revolution of Complex Engineered Systems

    E-Print Network [OSTI]

    Gómez-Cruz, Nelson Alfonso

    2011-01-01T23:59:59.000Z

    Provided that there is no theoretical frame for complex engineered systems (CES) as yet, this paper claims that bio-inspired engineering can help provide such a frame. Within CES bio-inspired systems play a key role. The disclosure from bio-inspired systems and biological computation has not been sufficiently worked out, however. Biological computation is to be taken as the processing of information by living systems that is carried out in polynomial time, i.e., efficiently; such processing however is grasped by current science and research as an intractable problem (for instance, the protein folding problem). A remark is needed here: P versus NP problems should be well defined and delimited but biological computation problems are not. The shift from conventional engineering to bio-inspired engineering needs bring the subject (or problem) of computability to a new level. Within the frame of computation, so far, the prevailing paradigm is still the Turing-Church thesis. In other words, conventional engineering...

  6. Title: From data analysis to network modeling, with applications in systems biology Author: Fabian J. Theis, Computational Modeling in Biology, Institute of Bioinformatics and

    E-Print Network [OSTI]

    Gerkmann, Ralf

    J. Theis, Computational Modeling in Biology, Institute of Bioinformatics and Systems BiologyTitle: From data analysis to network modeling, with applications in systems biology Author: Fabian at detailed models of the system of interest. Our application focus are biological networks, namely gene

  7. Analysis and design of high frequency link power conversion systems for fuel cell power conditioning 

    E-Print Network [OSTI]

    Song, Yu Jin

    2005-11-01T23:59:59.000Z

    In this dissertation, new high frequency link power conversion systems for the fuel cell power conditioning are proposed to improve the performance and optimize the cost, size, and weight of the power conversion systems. ...

  8. Analysis and design of high frequency link power conversion systems for fuel cell power conditioning

    E-Print Network [OSTI]

    Song, Yu Jin

    2005-11-01T23:59:59.000Z

    In this dissertation, new high frequency link power conversion systems for the fuel cell power conditioning are proposed to improve the performance and optimize the cost, size, and weight of the power conversion systems. The first study proposes a...

  9. EXTENSIONS OF LINKING SYSTEMS WITH p-GROUP KERNEL BOB OLIVER AND JOANA VENTURA

    E-Print Network [OSTI]

    Ventura, Joana

    EXTENSIONS OF LINKING SYSTEMS WITH p-GROUP KERNEL BOB OLIVER AND JOANA VENTURA Abstract. We study. Oliver is partially supported by UMR 7539 of the CNRS. J. Ventura is partially supported by FCT. #12;2 BOB OLIVER AND JOANA VENTURA enother prolem is tht in generlD when ev is linking system nd A g

  10. Biological Systems Science Division (BSSD) | U.S. DOE Office of Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials Find Find More LikeAndreasHelp(SC) Biological Systems

  11. A Model for a Linked System of Multi-Purpose Reservoirs with Stochastic Inflows and Demands

    E-Print Network [OSTI]

    Curry, G. L.; Helm, J. C.; Clark, R. A.

    TR-41 1972 A Model for a Linked System of Mulit-Purpose Reservoirs with Stochastic Inflows and Demands G.L. Curry J.C. Helm R.A. Clark Texas Water Resources Institute Texas A&M University ...

  12. DRAFT Syllabus for Energy Systems & Climate Change, Winter 2010 (See Moodle for updates and links)

    E-Print Network [OSTI]

    DRAFT Syllabus for Energy Systems & Climate Change, Winter 2010 (See Moodle for updates and links research & Faculty office hours 26 Feb. Gore Ch.8 (Nuclear); Start Seminar on Revenge of Gaia Week 9 1 Mar

  13. Earth System Modeling Facility: Linking Climate to Cal-(IT)2 and OptIPuter

    E-Print Network [OSTI]

    Rose, Michael R.

    Earth System Modeling Facility: Linking Climate to Cal-(IT)2 and OptIPuter Charlie Zender in quantitatively-based environmental planning. #12;1. Overview Present: 1. Earth System Modeling Facility (ESMF) 2 and Planning #12;2. Earth System Modeling Facility (ESMF) Background: In 2003, NSF, UCI, & IGPP awarded $1.3M

  14. Postdoctoral opportunities are available immediately in a project investigating molecular mechanisms of neurogenic hypertension. We take a systems biology

    E-Print Network [OSTI]

    Pillow, Jonathan

    mechanisms of neurogenic hypertension. We take a systems biology approach involving high-throughput data

  15. Biochemistry & Molecular Biology Department of Environmental and Biomolecular Systems

    E-Print Network [OSTI]

    Chapman, Michael S.

    Biology _____ _____ _____ EBS 514 ­ Biochemistry III: Metabolism and Bioenergetics Biology _____ _____ _____ EBS 614 ­ Biochemistry III: Metabolism and Bioenergetics _____ _____ _____ Three (3) of the following courses are required: EBS 625 ­ Bioenergetics and Membrane Transport

  16. Embedded calibration system for the DIII-D Langmuir probe analog fiber optic links

    SciTech Connect (OSTI)

    Watkins, J. G. [Sandia National Laboratories, Livermore, California (United States); Rajpal, R.; Mandaliya, H. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat (India); Watkins, M.; Boivin, R. L. [General Atomics, San Diego, California (United States)

    2012-10-15T23:59:59.000Z

    This paper describes a generally applicable technique for simultaneously measuring offset and gain of 64 analog fiber optic data links used for the DIII-D fixed Langmuir probes by embedding a reference voltage waveform in the optical transmitted signal before every tokamak shot. The calibrated data channels allow calibration of the power supply control fiber optic links as well. The array of fiber optic links and the embedded calibration system described here makes possible the use of superior modern data acquisition electronics in the control room.

  17. Biologically-based signal processing system applied to noise removal for signal extraction

    DOE Patents [OSTI]

    Fu, Chi Yung; Petrich, Loren I.

    2004-07-13T23:59:59.000Z

    The method and system described herein use a biologically-based signal processing system for noise removal for signal extraction. A wavelet transform may be used in conjunction with a neural network to imitate a biological system. The neural network may be trained using ideal data derived from physical principles or noiseless signals to determine to remove noise from the signal.

  18. Protecting a HVDC link against accidental isolation from its receiving AC system

    SciTech Connect (OSTI)

    Whitehouse, R.S. (GEC Alsthom Transmission and Distribution Projects Ltd., Stafford (United Kingdom))

    1993-07-01T23:59:59.000Z

    When an HVdc scheme is isolated from its receiving ac system, the inverter may continue to operate, generating its own ac bus voltages; this is defined here as islanding. If islanding is allowed to continue unrestricted, then main circuit components may in some conditions be damaged and it is therefore necessary to provide a suitable protection system. This paper outlines the protection scheme developed for the McNeill Back-to-Back HVdc link in Alberta, Canada, to prevent damage due to islanding while still permitting the link to automatically restart on reclosure of the isolating breaker. Oscillograms showing the protection in operation on both the GEC ALSTHOM HVdc simulator and during tests carried out as part of the commissioning of the McNeill HV dc link are included.

  19. Selection of bioclimatically representative biological reserve systems under climate change

    E-Print Network [OSTI]

    Pyke, C R; Fischer, Douglas T

    2005-01-01T23:59:59.000Z

    of bioclimatically representative biological reserve systemsthat are bioclimatically representative across a range ofa ?at line (i.e. a representative sample of current climate

  20. ECEN 720 High-Speed Links Circuits and Systems Lab1 -Transmission Lines

    E-Print Network [OSTI]

    Palermo, Sam

    1 ECEN 720 High-Speed Links Circuits and Systems Lab1 - Transmission Lines Objective To learn transmission lines and time-domain refectometer (TDR). Introduction Wires are used to transmit clocks and data data communication chip design, the wires are often treated as transmission lines. Proper transmission

  1. ECEN 720 High-Speed Links: Circuits and Systems Lab1 -Transmission Lines

    E-Print Network [OSTI]

    Palermo, Sam

    1 ECEN 720 High-Speed Links: Circuits and Systems Lab1 - Transmission Lines Objective To learn about transmission lines and time-domain reflectometer (TDR). Introduction Wires are used to transmit. In high speed data communication chip design, the wires are often treated as transmission lines. Proper

  2. EXTENSIONS OF LINKING SYSTEMS WITH p-GROUP KERNEL BOB OLIVER AND JOANA VENTURA

    E-Print Network [OSTI]

    Oliver, Bob

    AND JOANA VENTURA Abstract. We study extensions of p-local finite groups where the kernel i* *s of the CNRS. J. Ventura is partially supported by FCT/POCTI/FEDER and grant PDCT/MAT/58497* */2004. Both;2 BOB OLIVER AND JOANA VENTURA Another problem is that in general, when eLis a linking system and A C e

  3. The OME Framework for genome-scale systems biology

    SciTech Connect (OSTI)

    Palsson, Bernhard O.; Ebrahim, Ali; Federowicz, Steve

    2014-12-19T23:59:59.000Z

    The life sciences are undergoing continuous and accelerating integration with computational and engineering sciences. The biology that many in the field have been trained on may be hardly recognizable in ten to twenty years. One of the major drivers for this transformation is the blistering pace of advancements in DNA sequencing and synthesis. These advances have resulted in unprecedented amounts of new data, information, and knowledge. Many software tools have been developed to deal with aspects of this transformation and each is sorely needed [1-3]. However, few of these tools have been forced to deal with the full complexity of genome-scale models along with high throughput genome- scale data. This particular situation represents a unique challenge, as it is simultaneously necessary to deal with the vast breadth of genome-scale models and the dizzying depth of high-throughput datasets. It has been observed time and again that as the pace of data generation continues to accelerate, the pace of analysis significantly lags behind [4]. It is also evident that, given the plethora of databases and software efforts [5-12], it is still a significant challenge to work with genome-scale metabolic models, let alone next-generation whole cell models [13-15]. We work at the forefront of model creation and systems scale data generation [16-18]. The OME Framework was borne out of a practical need to enable genome-scale modeling and data analysis under a unified framework to drive the next generation of genome-scale biological models. Here we present the OME Framework. It exists as a set of Python classes. However, we want to emphasize the importance of the underlying design as an addition to the discussions on specifications of a digital cell. A great deal of work and valuable progress has been made by a number of communities [13, 19-24] towards interchange formats and implementations designed to achieve similar goals. While many software tools exist for handling genome-scale metabolic models or for genome-scale data analysis, no implementations exist that explicitly handle data and models concurrently. The OME Framework structures data in a connected loop with models and the components those models are composed of. This results in the first full, practical implementation of a framework that can enable genome-scale design-build-test. Over the coming years many more software packages will be developed and tools will necessarily change. However, we hope that the underlying designs shared here can help to inform the design of future software.

  4. Enhanced visible and near-infrared capabilities of the JET mirror-linked divertor spectroscopy system

    SciTech Connect (OSTI)

    Lomanowski, B. A., E-mail: b.a.lomanowski@durham.ac.uk; Sharples, R. M. [Centre for Advanced Instrumentation, Department of Physics, Durham University, Durham DH1 3LE (United Kingdom); Meigs, A. G.; Conway, N. J.; Zastrow, K.-D.; Heesterman, P.; Kinna, D. [EURATOM/CCFE Fusion Association, Culham Science Center, Abingdon OX14 3DB (United Kingdom); Collaboration: JET-EFDA Team

    2014-11-15T23:59:59.000Z

    The mirror-linked divertor spectroscopy diagnostic on JET has been upgraded with a new visible and near-infrared grating and filtered spectroscopy system. New capabilities include extended near-infrared coverage up to 1875 nm, capturing the hydrogen Paschen series, as well as a 2 kHz frame rate filtered imaging camera system for fast measurements of impurity (Be II) and deuterium D?, D?, D? line emission in the outer divertor. The expanded system provides unique capabilities for studying spatially resolved divertor plasma dynamics at near-ELM resolved timescales as well as a test bed for feasibility assessment of near-infrared spectroscopy.

  5. Implementation guidance for industrial-level security systems using radio frequency alarm links

    SciTech Connect (OSTI)

    Swank, R.G.

    1996-07-12T23:59:59.000Z

    Spread spectrum (SS) RF transmission technologies have properties that make the transmitted signal difficult to intercept, interpret, and jam. The digital code used in the modulation process results in a signal that has high reception reliability and supports multiple use of frequency bands and selective addressing. These attributes and the relatively low installation cost of RF systems make SSRF technologies candidate for communications links in security systems used for industrial sites, remote locations, and where trenching or other disturbances of soil or structures may not be desirable or may be costly. This guide provides a description of such a system and presents implementation methods that may be of engineering benefit.

  6. A Platform-Based Design Environment for Synthetic Biological Systems

    E-Print Network [OSTI]

    Densmore, Douglas

    in drug pro- duction, biofuels, and drug delivery vessels. In an attempt to standardize this process, and the notion of both "top down" and "bottom up" design styles. 1.1 Requirements In the world of biology one can

  7. Modeling the segment polarity gene network First: System is biologically defined; known expression patterns

    E-Print Network [OSTI]

    Albert, Réka

    are assumed to be not expressed. · Generate a set of kinetic parameters from the biologically relevant rangeModeling the segment polarity gene network First: System is biologically defined; known expression Boolean model: mRNA and protein activity is switch-like Validation: reproduces known gene expression

  8. Modeling complex biological flows in multi-scale systems using the APDEC framework

    E-Print Network [OSTI]

    Modeling complex biological flows in multi-scale systems using the APDEC framework David Trebotich methods are based on higher-order finite difference methods in complex geometry with adaptivity-mail: trebotich1@llnl.gov Abstract. We have developed advanced numerical algorithms to model biological fluids

  9. Dissolved metal contamination in the East RiverLong Island sound system: potential biological effects

    E-Print Network [OSTI]

    Johnsen, Sönke

    in the United States. The ER­WLIS region receives treated sewage from 18 wastewater treatment plants in New YorkDissolved metal contamination in the East River­Long Island sound system: potential biological sewage, and to assess its possible biological impact on local waters. The East River­Long Island Sound

  10. Computational and Systems Biology DOI: 10.1039/b921381n

    E-Print Network [OSTI]

    Babu, M. Madan

    in an exciting time in biology where the availability of such data permits us to investigate funda- mental. This diversity in problems that one can currently address is well illustrated by the articles published this data, (c) develop mathematical models of biological systems with predictive power and (d) uncover

  11. CB26CH23-Ideker ARI 26 June 2010 20:15 A Decade of Systems Biology

    E-Print Network [OSTI]

    advances in soft- ware tools that allow biologists to explore system-wide models and to formulate newCB26CH23-Ideker ARI 26 June 2010 20:15 R E V I E W S IN A D V A N CE A Decade of Systems Biology) Abstract Systems biology provides a framework for assembling models of biolog- ical pathways from

  12. The Bioinformatics & Systems Biology group (http://bioinformatics.psb.ugent.be/) at the VIB Department of Plant

    E-Print Network [OSTI]

    Gent, Universiteit

    The Bioinformatics & Systems Biology group (http://bioinformatics.psb.ugent.be/) at the VIB in the computational systems biology research group, you will be responsible for the commercialization of our software and food companies to present our in-house systems biology software tools. Profile: · PhD in computational

  13. Hemodynamically Driven Vein Graft Remodeling: A Systems Biology Approach

    E-Print Network [OSTI]

    Garbey, Marc

    no influence on the clinical outcomes following vein graft implantation. Analysis of the decision points vascular biology literature into the clinical care of patients. Recent failures in the Corgentech in an animal vein graft model, human phase I and II clinical studies were initiated.1-3 Demonstrating safety

  14. Linking home energy rating systems with energy efficiency financing: Progress on national and state programs

    SciTech Connect (OSTI)

    Farhar, B.C.; Collins, N.E.; Walsh, R.W.

    1996-10-01T23:59:59.000Z

    In 1991 and early 1992, the U.S. Department of Energy (DOE), in cooperation with the U.S. Department of Housing and Urban Development (HUD), established a National Collaborative on Home Energy Rating Systems (HERS) and Energy Efficient Mortgages (EEMs). The Collaborative's purpose was to involve stakeholders at a national policy level to develop a plan leading the nation toward a voluntary system linking HERS with EEMs. The National Renewable Energy Laboratory (NREL) coordinated the National Collaborative's meetings for DOE. Composed of representatives from 25 stakeholder organizations, the Collaborative, after some 14 meetings, reached consensus on two documents, both published by NREL in mg 1992: A National Program for Energy-Efficient Mortgages and Home Energy Rating Systems: A Blueprint for Action and Going National with HERS and EEMs: Issues and Impacts, The Collected Papers of the National Collaborative.

  15. Building the DOE Systems Biology Knowledgebase (KBase) ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema (OSTI)

    Brettin, Tom [Oak Ridge National Laboratory

    2013-03-22T23:59:59.000Z

    Tom Brettin on "Building the DOE Systems Biology Knowledgebase (KBase)" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  16. Cancer Systems Biology Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon,

    E-Print Network [OSTI]

    Smith, V Anne

    245 Chapter 12 Cancer Systems Biology Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon+Business Media, LLC 2010 #12;246 Faratian et al. While cancer can arise from any cell in the body, the commonest

  17. Techniques for Probing the Processes by Which Microwaves Interact with Chemical and Biological Systems 

    E-Print Network [OSTI]

    Kay, Philip E

    2007-01-01T23:59:59.000Z

    Microwave heating is a relatively mature field and is theoretically well understood. However, recently there has been debate as to whether microwaves can interact with chemical and biological systems by means other than ...

  18. DOE Systems Biology Knowledgebase (KBASE) (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    SciTech Connect (OSTI)

    Arkin, Adam [LBNL] [LBNL

    2012-03-21T23:59:59.000Z

    Adam Arkin from Berkeley Lab on the DOE Systems Biology Knowledgebase (KBASE) at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, Calif

  19. A PLL-Based Frequency Shift Measurement System for Chemical and Biological Sensing 

    E-Print Network [OSTI]

    Torke, William

    2012-02-14T23:59:59.000Z

    A PLL-based frequency shift measurement system for chemical and biological sensing was developed and implemented in the form of two discrete electronic assemblies. One of the assemblies consists of a VCO which contains a ...

  20. DOE Systems Biology Knowledgebase (KBASE) (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    ScienceCinema (OSTI)

    Arkin, Adam [LBNL

    2013-01-15T23:59:59.000Z

    Adam Arkin from Berkeley Lab on the DOE Systems Biology Knowledgebase (KBASE) at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, Calif

  1. Community Page A Holistic Approach to Marine Eco-Systems Biology

    E-Print Network [OSTI]

    Sullivan, Matthew B.

    Community Page A Holistic Approach to Marine Eco-Systems Biology Eric Karsenti1 *, Silvia G. Acinas-year study of the global ocean ecosystem aboard the ship Tara. A unique sampling programme encompass

  2. Report on Energy Deposition Calculations on the Magnesium Diboride Superconducting Links for the Cold Powering System Deliverable: D6.6

    E-Print Network [OSTI]

    Bignami, A; Santini, C

    2015-01-01T23:59:59.000Z

    Report on Energy Deposition Calculations on the Magnesium Diboride Superconducting Links for the Cold Powering System

  3. Development of New Soft Ionization Mass Spectrometry Approaches for Spatial Imaging of Complex Chemical and Biological Systems

    E-Print Network [OSTI]

    Development of New Soft Ionization Mass Spectrometry Approaches for Spatial Imaging of Complex Chemical and Biological Systems Research Team: Julia Laskin, Ljiljana Pasa-Toli, Brandi Heath, Ingela to multiple chemical and biological systems Key Successes Developed unique tools for imaging biological

  4. The Bioinformatics & Systems Biology group (http://bioinformatics.psb.ugent.be/) at the VIB Department of Plant

    E-Print Network [OSTI]

    Gent, Universiteit

    The Bioinformatics & Systems Biology group (http://bioinformatics.psb.ugent.be/) at the VIB Administrator/Bioinformatician As a member of VIB's a new bioinformatics project framed in the computational Department of Plant Systems Biology studies the structure, function and evolution of biological networks

  5. 7.91J / 7.36J / 20.490J Foundations of Computational and Systems Biology, Spring 2004

    E-Print Network [OSTI]

    Burge, Christopher

    Serving as an introduction to computational biology, this course emphasizes the fundamentals of nucleic acid and protein sequence analysis, structural analysis, and the analysis of complex biological systems. The principles ...

  6. Method And System For Examining Biological Materials Using Low Power Cw Excitation Raman Spectroscopy.

    DOE Patents [OSTI]

    Alfano, Robert R. (Bronx, NY); Wang, Wubao (Flushing, NY)

    2003-05-06T23:59:59.000Z

    A method and system for examining biological materials using low-power cw excitation Raman spectroscopy. A low-power continuous wave (cw) pump laser beam and a low-power cw Stokes (or anti-Stokes) probe laser beam simultaneously illuminate a biological material and traverse the biological material in collinearity. The pump beam, whose frequency is varied, is used to induce Raman emission from the biological material. The intensity of the probe beam, whose frequency is kept constant, is monitored as it leaves the biological material. When the difference between the pump and probe excitation frequencies is equal to a Raman vibrational mode frequency of the biological material, the weak probe signal becomes amplified by one or more orders of magnitude (typically up to about 10.sup.4 -10.sup.6) due to the Raman emission from the pump beam. In this manner, by monitoring the intensity of the probe beam emitted from the biological material as the pump beam is varied in frequency, one can obtain an excitation Raman spectrum for the biological material tested. The present invention may be applied to in the in vivo and/or in vitro diagnosis of diabetes, heart disease, hepatitis, cancers and other diseases by measuring the characteristic excitation Raman lines of blood glucose, cholesterol, serum glutamic oxalacetic transaminase (SGOT)/serum glutamic pyruvic transaminase (SGPT), tissues and other corresponding Raman-active body constituents, respectively.

  7. Minor in Agricultural Systems Management The Department of Biological and Agricultural Engineering

    E-Print Network [OSTI]

    Minor in Agricultural Systems Management Offered by The Department of Biological and Agricultural Engineering College of Agriculture and Life Sciences The minor in Agricultural Systems Management is available is to provide students, majoring in other fields, with a fundamental knowledge of the fields of agricultural

  8. Thermodynamics for Systems Biology Peter Salamon, Anna Salamon, and Andrzej Konopka

    E-Print Network [OSTI]

    Salamon, Peter

    1 Thermodynamics for Systems Biology Peter Salamon, Anna Salamon, and Andrzej Konopka Department to thermodynamics designed specifically for the needs of the systems biologist. It departs from modern treatments of the subject that have to do with modeling, i.e. to communicate thermodynamics as a body of worldviews, methods

  9. Exploring the free-energy landscapes of biological systems with steered molecular dynamics

    E-Print Network [OSTI]

    Chen, Liao Y.

    1 Exploring the free-energy landscapes of biological systems with steered molecular dynamics fluctuation-dissipation-theorem (BD -FDT) to accurately compute the free-energy profiles for several compute the free-energy profiles for all the afore-listed systems that represent various important aspects

  10. Systems Biology in Prokaryote - Eukaryote Symbiosis | Stanford Synchrotron

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solid ...SuccessSurprisingSynchrotronsPlasma Physics

  11. Renewable Hydrogen Production from Biological Systems | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of ContaminationHubs+18,new2004_v1.3_5.0.zipFlorida4Visitors3(Presentation) |Energy

  12. Bridging the gap between systems biology and medicine

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    Progress in developing meaningful ontologies for systems medicinemedicine, facilitated by enhanced visibility in the more clinically oriented medical literature, will be essential to chart effort and progress.

  13. Quantitative Languages for Complex Systems Applied to Biological Structure

    E-Print Network [OSTI]

    representations of the system. We illustrate the development of such languages using the structure of Drosophila this problem as well as to promote the study of complex systems as a systematic discipline, we seek to develop, life cycle stages, mutant abnormalities, gene expression patterns, genetic interactions, etc. In order

  14. IntegromeDB: an integrated system and biological search engine

    E-Print Network [OSTI]

    Baitaluk, Michael; Kozhenkov, Sergey; Dubinina, Yulia; Ponomarenko, Julia

    2012-01-01T23:59:59.000Z

    Wright A: Searching the Deep Web. CACM 2008, 51(10):14-15.a semantic, graph based, ‘deep web’ data integration systemIntegromeDB to tap into the Deep Web, the portion of the web

  15. Nonlinear stochastic system identification techniques for biological tissues/

    E-Print Network [OSTI]

    Chen, Yi, S.M. Massachusetts Institute of Technology

    2010-01-01T23:59:59.000Z

    This research develops a device capable of measuring the nonlinear dynamic mechanical properties of human tissue in vivo. The enabling technology is the use of nonlinear stochastic system identification techniques in ...

  16. Cool Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cool Links Explore Science Explore Explore these Topics Activities Videos Cool Links Favorite Q&A invisible utility element Cool Links Los Alamos National Laboratory links Los...

  17. On existence and uniqueness of the carrying simplex for competitive dynamical systems

    E-Print Network [OSTI]

    Hirsch, Morris W

    2008-01-01T23:59:59.000Z

    simplex for competitive dynamical systems',Journal of Biological Dynamics,2:2,169 — 179 To link to this Article:

  18. System for monitoring an industrial or biological process

    DOE Patents [OSTI]

    Gross, Kenneth C. (Argonne, IL); Wegerich, Stephan W. (Argonne, IL); Vilim, Rick B. (Argonne, IL); White, Andrew M. (Skokie, IL)

    1998-01-01T23:59:59.000Z

    A method and apparatus for monitoring and responding to conditions of an industrial process. Industrial process signals, such as repetitive manufacturing, testing and operational machine signals, are generated by a system. Sensor signals characteristic of the process are generated over a time length and compared to reference signals over the time length. The industrial signals are adjusted over the time length relative to the reference signals, the phase shift of the industrial signals is optimized to the reference signals and the resulting signals output for analysis by systems such as SPRT.

  19. "Creating computational models of biological systems to better combat

    E-Print Network [OSTI]

    Acton, Scott

    that could be used for biofuel and other metabolic engineering applications. · Performed high of Microbial Pathogens Infectious disease is the leading cause of death worldwide. While genomics has had system in biofuel and nutraceutical production. With the aid of computational techniques, we can predict

  20. Optimiziing the laboratory monitoring of biological wastewater-purification systems

    SciTech Connect (OSTI)

    S.V. Gerasimov [OAO Koks, Kemerovo (Russian Federation)

    2009-05-15T23:59:59.000Z

    Optimization of the laboratory monitoring of biochemical wastewater-treatment systems at coke plants is considered, for the example of OAO Koks. By adopting a methodological approach to determine the necessary data from chemical analysis, it is possible to reduce the time, labor, and materials required for monitoring, without impairing the purification process or compromising the plant's environmental policies.

  1. Specific Cation Effects in Biological Systems: Thermodynamic and Spectroscopic Insights

    E-Print Network [OSTI]

    Kherb, Jaibir

    2012-02-14T23:59:59.000Z

    and energy of the generated beam was 50 mJ/pulse. The fundamental 1064 laser beam was then sent to an optical parametric generator/amplifier (OPG/OPA) stage system ((LaserVision, Bellevue, WA).46 Firstly, the horizontally polarized 1064 nm beam....8 Schematic diagram showing the principle of vibrational sum frequency spectroscopy (VSFS). a) Temporal and spatial overlapping of input infrared and visible beams at the sample surface to generate the sum frequency...

  2. Method And System For Examining Biological Materials Using Low Power Cw Excitation Raman Spectroscopy.

    DOE Patents [OSTI]

    Alfano, Robert R. (Bronx, NY); Wang, Wubao (Flushing, NY)

    2000-11-21T23:59:59.000Z

    A method and system for examining biological materials using low-power cw excitation Raman spectroscopy. In accordance with the teachings of the invention, a low-power continuous wave (cw) pump laser beam and a low-power cw Stokes (or anti-Stokes) probe laser beam simultaneously illuminate a biological material and traverse the biological material in collinearity. The pump beam, whose frequency is varied, is used to induce Raman emission from the biological material. The intensity of the probe beam, whose frequency is kept constant, is monitored as it leaves the biological material. When the difference between the pump and probe excitation frequencies is equal to a Raman vibrational mode frequency of the biological material, the weak probe signal becomes amplified by one or more orders of magnitude (typically up to about 10.sup.4 -10.sup.6) due to the Raman emission from the pump beam. In this manner, by monitoring the intensity of the probe beam emitted from the biological material as the pump beam is varied in frequency, one can obtain an excitation Raman spectrum for the biological material tested. The present invention may be applied to in the in vivo and/or in vitro diagnosis of diabetes, heart disease, hepatitis, cancers and other diseases by measuring the characteristic excitation Raman lines of blood glucose, cholesterol, serum glutamic oxalacetic transaminase (SGOT)/serum glutamic pyruvic tansaminase (SGPT), tissues and other corresponding Raman-active body constituents, respectively. For example, it may also be used to diagnose diseases associated with the concentration of Raman-active constituents in urine, lymph and saliva It may be used to identify cancer in the breast, cervix, uterus, ovaries and the like by measuring the fingerprint excitation Raman spectra of these tissues. It may also be used to reveal the growing of tumors or cancers by measuring the levels of nitric oxide in tissue.

  3. Acoustic and biological studies of pitched blade mixing systems

    E-Print Network [OSTI]

    Hsi, Randolph Paul

    1986-01-01T23:59:59.000Z

    , and fermentation time and their efl'ect on cell growth; and the effectiveness of mixing conditions to be determined by the degree of balance between efficient mass transfer and low shear rates. DEDICATION This thesis is dedicated to Mindy Hsi whose untimely... in this work; Dr. Mike Midler for providing the chemicals used for medium; Dr. Dan Taylor for allowing the use of the Microgen fermenter and supporting systems; and Dr. Albert Watson l'or allowing use of the Carl Zeiss binocular microscope for bacterial cell...

  4. Published in IET Systems Biology Received on 2nd February 2009

    E-Print Network [OSTI]

    Schaffer, David V.

    .1049/iet-syb.2009.0011 ISSN 1751-8849 Systems biology approaches to understanding stem cell fate choice J. Peltier1 D.V. Schaffer2 1 Department of Chemical Engineering, University of California, 176 Stanley Hall-3220, USA E-mail: schaffer@berkeley.edu Abstract: Stem cells have the capability to self-renew and maintain

  5. DEPARTMENT OF CELL AND SYSTEMS BIOLOGY GRADUATE AWARDS 2010 Valerie Anderson Award

    E-Print Network [OSTI]

    Toronto, University of

    Andrew McKinley and Arash Tadjalli 2008 Norman Lee 2007 Starlee Lively 2006 Anna Price #12;Hilbert & Chung Huoi Ung 2007 Amy Lee 2006 Marion Andrew #12;Duncan L. Gellatly Memorial Fellowship To be awarded Andrew Catalano 2006 Shelley Lumba Senior Alumni Association Prize in Cell & Systems Biology

  6. 8 Prospects for Biological Carbon Sinks in Greenhouse Gas Emissions Trading Systems

    E-Print Network [OSTI]

    8 Prospects for Biological Carbon Sinks in Greenhouse Gas Emissions Trading Systems John Reilly1. With emissions trading, emitters who found they could cheaply reduce their emissions might have allowances- ing Australia, Canada, Japan and Russia. This group also pushed strongly for inter- national emissions

  7. Theory: Biological systems organize to maximize entropy production subject to information and biophysicochemical constraints.

    E-Print Network [OSTI]

    Vallino, Joseph J.

    Theory: Biological systems organize to maximize entropy production subject to information the fitness landscape is as dynamic as the organisms themselves. The theory of MEP under biophysicochemical, 2005b) presented a provisional proof on the theory of maximum entropy production (MEP), which posits

  8. Toward Systems Biology in Brown Algae to Explore Acclimation and Adaptation to the Shore Environment

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Toward Systems Biology in Brown Algae to Explore Acclimation and Adaptation to the Shore,2 Catherine Boyen,1,2 and Anne Siegel4,5 Abstract Brown algae belong to a phylogenetic lineage distantly siliculosus as a model organism for brown algae has represented a framework in which several omics techniques

  9. Final report for Conference Support Grant "From Computational Biophysics to Systems Biology - CBSB12"

    SciTech Connect (OSTI)

    Hansmann, Ulrich H.E.

    2012-07-02T23:59:59.000Z

    This report summarizes the outcome of the international workshop �From Computational Biophysics to Systems Biology (CBSB12)� which was held June 3-5, 2012, at the University of Tennessee Conference Center in Knoxville, TN, and supported by DOE through the Conference Support Grant 120174. The purpose of CBSB12 was to provide a forum for the interaction between a data-mining interested systems biology community and a simulation and first-principle oriented computational biophysics/biochemistry community. CBSB12 was the sixth in a series of workshops of the same name organized in recent years, and the second that has been held in the USA. As in previous years, it gave researchers from physics, biology, and computer science an opportunity to acquaint each other with current trends in computational biophysics and systems biology, to explore venues of cooperation, and to establish together a detailed understanding of cells at a molecular level. The conference grant of $10,000 was used to cover registration fees and provide travel fellowships to selected students and postdoctoral scientists. By educating graduate students and providing a forum for young scientists to perform research into the working of cells at a molecular level, the workshop adds to DOE's mission of paving the way to exploit the abilities of living systems to capture, store and utilize energy.

  10. 28 IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, VOL. 1, NO. 1, MARCH 2007 Feedback Analysis and Design of RF Power Links for

    E-Print Network [OSTI]

    Sarpeshkar, Rahul

    structure of an inductive power link system for an example implant. An RF power amplifier drives a primary Analysis and Design of RF Power Links for Low-Power Bionic Systems Michael W. Baker, Student Member, IEEE for analyzing and designing RF power links for transcutaneous bionic systems, i.e., between an external RF coil

  11. EMSL Research and Capability Development Proposals Development of Live and LC-NMR Microbial Metabolomics Methods for Systems Biology Studies

    E-Print Network [OSTI]

    Metabolomics Methods for Systems Biology Studies: A Test Case Relevant to Biofuels Production Project start for enhanced systems biology studies. There are two specific objectives: 1) develop and cross-validate unique analysis, and 2) apply this improved metabolomics capability to study microbial processes relevant

  12. EDITOR OF CONFERENCE PROCEEDINGS: 17. Health Monitoring of Structural and Biological Systems 2011 , Ed. T. Kundu, Pub.

    E-Print Network [OSTI]

    Wong, Pak Kin

    EDITOR OF CONFERENCE PROCEEDINGS: 17. Health Monitoring of Structural and Biological Systems 2011/NDE, March 7-10, 2011, San Diego, California, Vol. 7984, 2011 16. Health Monitoring of Structural 9780819475558, 2009. 14. Health Monitoring of Structural and Biological Systems 2008 , Ed. T. Kundu, Pub. SPIE

  13. Structure and Dynamics of Biological Systems Research Team: James E. Evans, Daniel E. Perea, Xiao-Ying Yu, Zihua Zhu

    E-Print Network [OSTI]

    Structure and Dynamics of Biological Systems Research Team: James E. Evans, Daniel E. Perea, Xiao for atomic resolution structure determination; observe dynamics using a pump-probe regime. Dynamic TEM probe tomography to interrogate the structure and dynamics of biological systems

  14. Interaction of biological systems with static and ELF electric and magnetic fields

    SciTech Connect (OSTI)

    Anderson, L.E.; Kelman, B.J.; Weigel, R.J. (eds.)

    1987-01-01T23:59:59.000Z

    Although background levels of atmospheric electric and geomagnetic field levels are extremely low, over the past several decades, human beings and other life forms on this planet have been subjected to a dramatically changing electromagnetic milieu. An exponential increase in exposure to electromagnetic fields has occurred, largely because of such technological advances as the growth of electrical power generation and transmission systems, the increased use of wireless communications, and the use of radar. In addition, electromagnetic field generating devices have proliferated in industrial plants, office buildings, homes, public transportation systems, and elsewhere. Although significant increases have occurred in electromagnetic field strenghths spanning all frequency ranges, this symposium addresses only the impact of these fields at static and extremely low frequencies (ELF), primarily 50 and 60 Hz. This volume contains the proceedings of the symposium entitled /open quotes/Interaction of biological systems with static and ELF electric and magnetic fields/close quotes/. The purpose of the symposium was to provide a forum for discussions of all aspects of research on the interaction of static and ELF electromagnetic fields with biological systems. These systems include simple biophysical models, cell and organ preparations, whole animals, and man. Dosimetry, exposure system design, and artifacts in ELF bioeffects research were also addressed, along with current investigations that examine fundamental mechanisms of interactions between the fields and biological processes. Papers are indexed separately.

  15. Investigating asparagine-linked protein glycosylation in eukaryotic and prokaryotic systems

    E-Print Network [OSTI]

    Weerapana, Eranthie

    2006-01-01T23:59:59.000Z

    N-linked protein glycosylation is characterized by the formation of a -glycosylamine linkage to an asparagine residue within the Asn-Xaa-Ser/Thr consensus sequence. This modification is found in organisms from eukaryotic, ...

  16. Investigation of asparagine-linked glycosylation in archaeal and bacterial systems

    E-Print Network [OSTI]

    Larkin, Angelyn (Angelyn Kathryne)

    2011-01-01T23:59:59.000Z

    Asparagine-linked protein glycosylation entails the stepwise assembly of an oligosaccharide onto a polyisoprenyl diphosphate carrier, followed by the en bloc transfer of the glycan onto acceptor proteins by oligosaccharyl ...

  17. Nanoscale Electromechanics of Ferroelectric and Biological Systems: A New Dimension in Scanning Probe Microscopy

    SciTech Connect (OSTI)

    Kalinin, Sergei V [ORNL; Rodriguez, Brian J [ORNL; Jesse, Stephen [ORNL; Karapetian, Edgar [ORNL; Mirman, B [Suffolk University, Boston; Eliseev, E. A. [National Academy of Science of Ukraine, Kiev, Ukraine; Morozovska, A. N. [National Academy of Science of Ukraine, Kiev, Ukraine

    2007-01-01T23:59:59.000Z

    Functionality of biological and inorganic systems ranging from nonvolatile computer memories and microelectromechanical systems to electromotor proteins and cellular membranes is ultimately based on the intricate coupling between electrical and mechanical phenomena. In the past decade, piezoresponse force microscopy (PFM) has been established as a powerful tool for nanoscale imaging, spectroscopy, and manipulation of ferroelectric and piezoelectric materials. Here, we give an overview of the fundamental image formation mechanism in PFM and summarize recent theoretical and technological advances. In particular, we show that the signal formation in PFM is complementary to that in the scanning tunneling microscopy (STM) and atomic force microscopy (AFM) techniques, and we discuss the implications. We also consider the prospect of extending PFM beyond ferroelectric characterization for quantitative probing of electromechanical behavior in molecular and biological systems and high-resolution probing of static and dynamic polarization switching processes in low-dimensional ferroelectric materials and heterostructures.

  18. Publish/Subscribe Systems on Node and Link Error-Prone

    E-Print Network [OSTI]

    tower Cellular W ireless LA N #12;Motivations Mobile environments are error prone · Wireless link · Comparison pub/sub to client- server and polling models ES EBS ES/ ED Radio tower ES Cellular Wireless Node (,T) (cost of periodic publish or polling) s(n) (effect of sharing among n subscribers) tps (time

  19. Linking Accelerating Laboratory Test with Outdoor Performance Results for a Model Epoxy Coating System

    E-Print Network [OSTI]

    located in Gaithersburg, MD. Panel temperature and ambient RH of the outdoor exposure and the solar of this type of polymeric material. 2 #12;INTRODUCTION Attempts at linking field and laboratory exposure of the specimens,5 differences in the spectral emission distributions of the sun and laboratory light sources

  20. Combined process for 2,4-Dichlorophenoxyacetic acid treatment Coupling of an electrochemical system with a biological treatment.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    system with a biological treatment. Jean-Marie Fontmorina,b *, Florence Fourcadea,b Florence Genestec-made electrochemical flow cell was used for the pre-treatment and a biological treatment was then carried out using activated sludge supplied by a local wastewater treatment plant. 2,4-D was used as a target compound

  1. Biological optimization systems for enhancing photosynthetic efficiency and methods of use

    DOE Patents [OSTI]

    Hunt, Ryan W.; Chinnasamy, Senthil; Das, Keshav C.; de Mattos, Erico Rolim

    2012-11-06T23:59:59.000Z

    Biological optimization systems for enhancing photosynthetic efficiency and methods of use. Specifically, methods for enhancing photosynthetic efficiency including applying pulsed light to a photosynthetic organism, using a chlorophyll fluorescence feedback control system to determine one or more photosynthetic efficiency parameters, and adjusting one or more of the photosynthetic efficiency parameters to drive the photosynthesis by the delivery of an amount of light to optimize light absorption of the photosynthetic organism while providing enough dark time between light pulses to prevent oversaturation of the chlorophyll reaction centers are disclosed.

  2. EIA - Natural Gas Pipeline System - Links to U.S. Natural Gas Pipeline

    Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613 122 40Coal Stocks at1,066,688 760,877 951,322DevelopmentConfiguration

  3. Grid-Interactive Electric Vehicle DC-Link Photovoltaic Charging System -

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField8,Dist.NewofGeothermal Heaton Armed Services U.S.GregoryGrid

  4. Experimental proposal for testing the Emergence of Environment Induced (EIN) Classical Selection rules with Biological Systems

    E-Print Network [OSTI]

    Thomas Durt

    2010-03-14T23:59:59.000Z

    According to the so-called Quantum Darwinist approach, the emergence of "classical islands" from a quantum background is assumed to obey a (selection) principle of maximal information. We illustrate this idea by considering the coupling of two oscillators (modes). As our approach suggests that the classical limit could have emerged throughout a long and progressive Evolution mechanism, it is likely that primitive living organisms behave in a "more quantum", "less classical" way than more evolved ones. This brings us to seriously consider the possibility to measure departures from classicality exhibited by biological systems. We describe an experimental proposal the aimed at revealing the presence of entanglement in the biophotonic radiation emitted by biological sources.

  5. Optimal Allocation of Interconnecting Links in Cyber-Physical Systems: Interdependence,

    E-Print Network [OSTI]

    Reisslein, Martin

    infrastructure net- works involving Internet services, power grids, and financial markets [3]. Real that these systems are more vulnerable to attacks since node failures in one network may result in (due to the collapse of the entire infrastructure. The robustness of interdependent systems against this sort

  6. A Study to Determine the Biological Feasibility of a New Fish Tagging System; Annual Report 1994-1996.

    SciTech Connect (OSTI)

    Downing, Sandra L.; Frost, Deborah A.; Jonasson, Bruce F.; Nunnallee, Edmund P.; Peterson, Bradley W.; Prentice, Earl F.; Snell, Glen A.

    1998-11-01T23:59:59.000Z

    A multiyear program to evaluate the technical and biological feasibility of a new identification system for salmonids established between the Bonneville Power Administration (BPA) and the National Marine Fisheries Service (NMFS) in 1983.

  7. Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options

    SciTech Connect (OSTI)

    Carter, Sarah R. [J. Craig Venter Institute; Rodemeyer, Michael [University of Virginia; Garfinkel, Michele S. [EMBO; Friedman, Robert M [J. Craig Venter Institute

    2014-05-01T23:59:59.000Z

    Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options Sarah R. Carter, Ph.D., J. Craig Venter Institute; Michael Rodemeyer, J.D., University of Virginia; Michele S. Garfinkel, Ph.D., EMBO; Robert M. Friedman, Ph.D., J. Craig Venter Institute In recent years, a range of genetic engineering techniques referred to as “synthetic biology” has significantly expanded the tool kit available to scientists and engineers, providing them with far greater capabilities to engineer organisms than previous techniques allowed. The field of synthetic biology includes the relatively new ability to synthesize long pieces of DNA from chemicals, as well as improved methods for genetic manipulation and design of genetic pathways to achieve more precise control of biological systems. These advances will help usher in a new generation of genetically engineered microbes, plants, and animals. The JCVI Policy Center team, along with researchers at the University of Virginia and EMBO, examined how well the current U.S. regulatory system for genetically engineered products will handle the near-term introduction of organisms engineered using synthetic biology. In particular, the focus was on those organisms intended to be used or grown directly in the environment, outside of a contained facility. The study concludes that the U.S. regulatory agencies have adequate legal authority to address most, but not all, potential environmental, health and safety concerns posed by these organisms. Such near-term products are likely to represent incremental changes rather than a marked departure from previous genetically engineered organisms. However, the study also identified two key challenges for the regulatory system, which are detailed in the report. First, USDA’s authority over genetically engineered plants depends on the use of an older engineering technique that is no longer necessary for many applications. The shift to synthetic biology and other newer genetic engineering techniques will leave many engineered plants without any pre-market regulatory review. Second, the number and diversity of engineered microbes for commercial use will increase in the near future, challenging EPA’s resources, expertise, and perhaps authority to regulate them. For each of these challenges, the report sets out a series of options, including an analysis of the advantages and disadvantages of each option from a variety of perspectives, for policy makers to consider. Policy responses will depend on the trade-offs chosen among competing considerations. This report, funded by the Department of Energy with additional funds from the Alfred P. Sloan Foundation, is the result of a two-year process that included interviews, commissioned background papers, discussions, and two workshops that sought input from a wide range of experts, including U.S. federal agency regulators, legal and science policy experts, representatives from the biotechnology indus¬try, and non-governmental organiza¬tions. This cross-section of views informed this report, but the conclusions are solely those of the authors. An Executive Summary, full Report, and background papers are available at: http://www.jcvi.org/cms/research/projects/synthetic-biology-and-the-us-biotechnology-regulatory-system/overview/

  8. Meteorological Integration for the Biological Warning and Incident Characterization (BWIC) System: General Guidance for BWIC Cities

    SciTech Connect (OSTI)

    Shaw, William J.; Wang, Weiguo; Rutz, Frederick C.; Chapman, Elaine G.; Rishel, Jeremy P.; Xie, YuLong; Seiple, Timothy E.; Allwine, K Jerry

    2007-02-16T23:59:59.000Z

    The U.S. Department of Homeland Security (DHS) is responsible for developing systems to detect the release of aerosolized bioagents in urban environments. The system that accomplishes this, known as BioWatch, is a robust first-generation monitoring system. In conjunction with the BioWatch detection network, DHS has also developed a software tool for cities to use to assist in their response when a bioagent is detected. This tool, the Biological Warning and Incident Characterization (BWIC) System, will eventually be deployed to all BioWatch cities to aid in the interpretation of the public health significance of indicators from the BioWatch networks. BWIC consists of a set of integrated modules, including meteorological models, that estimate the effect of a biological agent on a city’s population once it has been detected. For the meteorological models in BWIC to successfully calculate the distribution of biological material, they must have as input accurate meteorological data, and wind fields in particular. The purpose of this document is to provide guidance for cities to use in identifying sources of good-quality local meteorological data that BWIC needs to function properly. This process of finding sources of local meteorological data, evaluating the data quality and gaps in coverage, and getting the data into BWIC, referred to as meteorological integration, is described. The good news for many cities is that meteorological measurement networks are becoming increasingly common. Most of these networks allow their data to be distributed in real time via the internet. Thus, cities will often only need to evaluate the quality of available measurements and perhaps add a modest number of stations where coverage is poor.

  9. Indoor Air Nuclear, Biological, and Chemical Health Modeling and Assessment System

    SciTech Connect (OSTI)

    Stenner, Robert D.; Hadley, Donald L.; Armstrong, Peter R.; Buck, John W.; Hoopes, Bonnie L.; Janus, Michael C.

    2001-03-01T23:59:59.000Z

    Indoor air quality effects on human health are of increasing concern to public health agencies and building owners. The prevention and treatment of 'sick building' syndrome and the spread of air-borne diseases in hospitals, for example, are well known priorities. However, increasing attention is being directed to the vulnerability of our public buildings/places, public security and national defense facilities to terrorist attack or the accidental release of air-borne biological pathogens, harmful chemicals, or radioactive contaminants. The Indoor Air Nuclear, Biological, and Chemical Health Modeling and Assessment System (IA-NBC-HMAS) was developed to serve as a health impact analysis tool for use in addressing these concerns. The overall goal was to develop a user-friendly fully functional prototype Health Modeling and Assessment system, which will operate under the PNNL FRAMES system for ease of use and to maximize its integration with other modeling and assessment capabilities accessible within the FRAMES system (e.g., ambient air fate and transport models, water borne fate and transport models, Physiologically Based Pharmacokinetic models, etc.). The prototype IA-NBC-HMAS is designed to serve as a functional Health Modeling and Assessment system that can be easily tailored to meet specific building analysis needs of a customer. The prototype system was developed and tested using an actual building (i.e., the Churchville Building located at the Aberdeen Proving Ground) and release scenario (i.e., the release and measurement of tracer materials within the building) to ensure realism and practicality in the design and development of the prototype system. A user-friendly "demo" accompanies this report to allow the reader the opportunity for a "hands on" review of the prototype system's capability.

  10. Methodology for integration of HVDC links in large ac systems. Phase I. Reference manual. Final report

    SciTech Connect (OSTI)

    Meredith, R.J.

    1983-03-01T23:59:59.000Z

    HVDC transmission has been found to be an attractive alternative to ac transmission in many situations. Evaluations of HVDC alternatives include technical, economic, environmental and sometimes regulatory considerations which are different than those for ac transmission. This research project resulted in the preparation of a HVDC reference manual which describes a comprehensive methodology for evaluating HVDC alternatives in utility transmission planning. It provides basic background information about existing HVDC systems. It describes the types of studies required and potential problems which must be dealt with. It also discusses how the studies are usually run and what system modeling is required. It emphasizes the importance of proper control of the dc system and provides examples of control systems which have been used.

  11. Biological and Environmental Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Focus Area team for Soil Metagenomics and Carbon Cycling develops and uses community genomics approaches to link the biological processes controlling belowground carbon storage...

  12. Optimal Allocation of Interconnecting Links in Cyber-Physical Systems: Interdependence,

    E-Print Network [OSTI]

    Yagan, Osman

    infrastructure networks involving Internet services, power grids and financial markets [3]. Real- world examples.zhang, cochran}@asu.edu School of Electrical, Computer and Energy Engineering Arizona State University, Tempe, AZ.e., a cyber-network overlaying a physical-network. It is envisioned that these systems are more vulnerable

  13. Information Surfaces in Systems Biology and Applications to Engineering Sustainable Agriculture

    E-Print Network [OSTI]

    Dashti, Hesam; Driver, James; Assadi, Amir

    2011-01-01T23:59:59.000Z

    Systems biology of plants offers myriad opportunities and many challenges in modeling. A number of technical challenges stem from paucity of computational methods for discovery of the most fundamental properties of complex dynamical systems. In systems engineering, eigen-mode analysis have proved to be a powerful approach. Following this philosophy, we introduce a new theory that has the benefits of eigen-mode analysis, while it allows investigation of complex dynamics prior to estimation of optimal scales and resolutions. Information Surfaces organizes the many intricate relationships among "eigen-modes" of gene networks at multiple scales and via an adaptable multi-resolution analytic approach that permits discovery of the appropriate scale and resolution for discovery of functions of genes in the model plant Arabidopsis. Applications are many, and some pertain developments of crops that sustainable agriculture requires.

  14. Biology 494 Biology Internship

    E-Print Network [OSTI]

    Wurtele, Eve Syrkin

    Biology 494 Biology Internship Guidelines The Biology Program encourages students to seek out and participate in internship opportunities that have a clear biological focus. Internships may be arranged may receive credit in Biology 494 (Biology Internship) for participation in internships, regardless

  15. Fast prediction of transient stability margin in systems with SVC control and HVDC link

    SciTech Connect (OSTI)

    Tso, S.K. [City Univ. of Hong Kong (Hong Kong). Dept. of Manufacturing Engineering; Cheung, S.P. [ABB Transmission and Distribution Ltd., Hong Kong (Hong Kong). Dept. of Power Systems

    1995-12-31T23:59:59.000Z

    Recent developments in transient stability margin (TSM) prediction using the energy-based direct method have included excitation controllers, power system stabilizers (PSSs) and/or static VAr compensators (SVCs). These devices can be represented in their detailed dynamic models to desired degrees of complexity while the proposed extended equal-area criterion can still be effectively applied. This paper describes further development of this technique to incorporate an HVDC transmission into the test network for TSM prediction. The method is examined with a practical 17-machine power network representing the South China/Hong Kong system. An SVC control scheme is also installed in a weak bus of the test network for transient stability improvement. The results obtained show that there is no sacrifice in accuracy, speed or reliability of the TSM method with SVC and HVDC realistically incorporated into the study.

  16. How sulphate-reducing microorganisms cope with stress: Lessons from systems biology

    SciTech Connect (OSTI)

    Zhou, J.; He, Q.; Hemme, C.L.; Mukhopadhyay, A.; Hillesland, K.; Zhou, A.; He, Z.; Nostrand, J.D. Van; Hazen, T.C.; Stahl, D.A.; Wall, J.D.; Arkin, A.P.

    2011-04-01T23:59:59.000Z

    Sulphate-reducing microorganisms (SRMs) are a phylogenetically diverse group of anaerobes encompassing distinct physiologies with a broad ecological distribution. As SRMs have important roles in the biogeochemical cycling of carbon, nitrogen, sulphur and various metals, an understanding of how these organisms respond to environmental stresses is of fundamental and practical importance. In this Review, we highlight recent applications of systems biology tools in studying the stress responses of SRMs, particularly Desulfovibrio spp., at the cell, population, community and ecosystem levels. The syntrophic lifestyle of SRMs is also discussed, with a focus on system-level analyses of adaptive mechanisms. Such information is important for understanding the microbiology of the global sulphur cycle and for developing biotechnological applications of SRMs for environmental remediation, energy production, biocorrosion control, wastewater treatment and mineral recovery.

  17. Final Report - Phylogenomic tools and web resources for the Systems Biology Knowledgebase

    SciTech Connect (OSTI)

    Sjolander, Kimmen

    2014-11-07T23:59:59.000Z

    The major advance during this last reporting period (8/15/12 to present) is our release of data on the PhyloFacts website: phylogenetic trees, multiple sequence alignments and other data for protein families are now available for download from http://phylogenomics.berkeley.edu/data/. This project as a whole aimed to develop high-throughput functional annotation systems that exploit information from protein 3D structure and evolution to provide highly precise inferences of various aspects of gene function, including molecular function, biological process, pathway association, Pfam domains, cellular localization and so on. We accomplished these aims by developing and testing different systems on a database of protein family trees: the PhyloFacts Phylogenomic Encyclopedia (at http://phylogenomics.berkeley.edu/phylofacts/ ).

  18. Co-Funding for the Conference on Magnetic Resonance in Biological Systems

    SciTech Connect (OSTI)

    Alan McLaughlin, Ph.D., Director, Division of Applied Science & Technology, NIBIB, NIH

    2008-10-01T23:59:59.000Z

    The XXIst International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2005), '60th anniversary of the discovery of Nuclear Magnetic Resonance,' was held between 16 and 21 January 2005 in Hyderabad, India. The meeting focused on a broad range of magnetic resonance methods as applied to studies of biological processes related to human health. The biennial ICMRBS has become the major venue for discussion of advances in nuclear and electron magnetic resonance (NMR & EMR/EPR) studies of the structure, dynamics, and chemical properties of important classes of biomolecules. Magnetic resonance has become an established tool in structural biology, and its special importance derives from its ability to provide atomic level information. It is becoming increasingly evident that the dynamic features of biomolecules, their intermolecular interactions, and accessible conformations in solution are data of key importance in understanding molecular recognition and function. NMR, which is already contributing to approximately 25% of the new structures being deposited with the Protein Data Bank, is destined to be a major player in the post genomic structure age with its emphasis on structure and function. In-vivo magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) results shed light on human metabolic processes and on the cellular ramifications of cancer, stroke, cardiovascular disease, and other pathologies. New methodologies in metabonomics may lead to development of new drugs and medical diagnosis. The ICMRBS is the one conference that brings together experts from high-resolution NMR, solid state NMR, EPR, in-vivo MRS and MRI, and developers of instrumentation, techniques, software, and databases. Symposia at this ICMRBS are designed to continue the fruitful cross-fertilization of ideas that has been so successful in driving the spectacular advances in this field. ICMRBS 2005 maintained the traditional format of poster sessions, and plenary lectures that highlight major advances in each of the major areas, and three parallel symposia that focused on particular biological systems, interfacial applications of magnetic resonance, and rapidly advancing technology. Funds provided partial travel support for 33 younger scientists from the U.S. (graduate students, postdoctoral research associates, and beginning faculty), selected from those who submitted accepted posters; 12 of these were invited to contribute oral presentations. Those receiving travel support were selected by a committee composed of the U.S. members of the International Advisory Committee for the meeting. Particular emphasis was placed on facilitating participation of minority and women scientists.

  19. Magnetophoretic bead trapping in a high-flowrate biological detection system.

    SciTech Connect (OSTI)

    Galambos, Paul C.; Hopkins, Matthew Morgan; Rahimian, Kamayar; Martin, James Ellis; Anderson, G. Ronald; Clem, Paul Gilbert; Rohwer, Lauren Elizabeth Shea; Lemp, Thomas; Derzon, Mark Steven; James, Conrad D.

    2005-03-01T23:59:59.000Z

    This report contains the summary of the 'Magnetophoretic Bead Trapping in a High-Flowrate Biological Detection System' LDRD project 74795. The objective of this project is to develop a novel biodetection system for high-throughput sample analysis. The chief application of this system is in detection of very low concentrations of target molecules from a complex liquid solution containing many different constituents--some of which may interfere with identification of the target molecule. The system is also designed to handle air sampling by using an aerosol system (for instance a WESP - Wet Electro-Static Precipitator, or an impact spray system) to get air sample constituents into the liquid volume. The system described herein automatically takes the raw liquid sample, whether air converted or initially liquid matrix, and mixes in magnetic detector beads that capture the targets of interest and then performs the sample cleanup function, allowing increased sensitivity and eliminating most false positives and false negatives at a downstream detector. The surfaces of the beads can be functionalized in a variety of ways in order to maximize the number of targets to be captured and concentrated. Bacteria and viruses are captured using antibodies to surface proteins on bacterial cell walls or viral particle coats. In combination with a cell lysis or PCR (Polymerase Chain Reaction), the beads can be used as a DNA or RNA probe to capture nucleic acid patterns of interest. The sample cleanup capability of this system would allow different raw biological samples, such as blood or saliva to be analyzed for the presence of different infectious agents (e.g. smallpox or SARS). For future studies, we envision functionalizing bead surfaces to bind to chemical weapons agents, radio-isotopes, and explosives. The two main objectives of this project were to explore methods for enhancing the mixing of the capture microspheres in the sample, and to develop a novel high-throughput magnetic microsphere trap. We have developed a novel technique using the magnetic capture microspheres as 'stirrer bars' in a fluid sample to enhance target binding to the microsphere surfaces. We have also made progress in developing a polymer-MEMS electromagnet for trapping magnetic spheres in a high-flowrate fluid format.

  20. Computer Simulations with Mathematica: Explorations in Complex Physical and Biological Systems, by Richard J. Gaylord and Paul R. Wellin. Springer-

    E-Print Network [OSTI]

    Scales, John

    not end up learning much about simulation per se or the systems supposedly being studied. Let me quoteComputer Simulations with Mathematica: Explorations in Complex Physical and Biological Systems simulations of natural phenomena have been used for as long as there have been computers. The first Monte

  1. Ultrashort pulse high repetition rate laser system for biological tissue processing

    DOE Patents [OSTI]

    Neev, J.; Da Silva, L.B.; Matthews, D.L.; Glinsky, M.E.; Stuart, B.C.; Perry, M.D.; Feit, M.D.; Rubenchik, A.M.

    1998-02-24T23:59:59.000Z

    A method and apparatus are disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment. 8 figs.

  2. Ultrashort pulse high repetition rate laser system for biological tissue processing

    DOE Patents [OSTI]

    Neev, Joseph (Laguna Beach, CA); Da Silva, Luiz B. (Danville, CA); Matthews, Dennis L. (Moss Beach, CA); Glinsky, Michael E. (Livermore, CA); Stuart, Brent C. (Fremont, CA); Perry, Michael D. (Livermore, CA); Feit, Michael D. (Livermore, CA); Rubenchik, Alexander M. (Livermore, CA)

    1998-01-01T23:59:59.000Z

    A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.

  3. Imaging corn plants with PhytoPET, a modular PET system for plant biology

    SciTech Connect (OSTI)

    Lee, S.; Kross, B.; McKisson, J.; McKisson, J. E.; Weisenberger, A. G.; Xi, W.; Zorn, C.; Bonito, G.; Howell, C. R.; Reid, C. D.; Crowell, A.; Cumberbatch, L. C.; Topp, C.; Smith, M. F.

    2013-11-01T23:59:59.000Z

    PhytoPET is a modular positron emission tomography (PET) system designed specifically for plant imaging. The PhytoPET design allows flexible arrangements of PET detectors based on individual standalone detector modules built from single Hamamatsu H8500 position sensitive photomultiplier tubes and pixelated LYSO arrays. We have used the PhytoPET system to perform preliminary corn plant imaging studies at the Duke University Biology Department Phytotron. Initial evaluation of the PhytoPET system to image the biodistribution of the positron emitting tracer {sup 11}C in corn plants is presented. {sup 11}CO{sub 2} is loaded into corn seedlings by a leaf-labeling cuvette and translocation of {sup 11}C-sugars is imaged by a flexible arrangement of PhytoPET modules on each side. The PhytoPET system successfully images {sup 11}C within corn plants and allows for the dynamic measurement of {sup 11}C-sugar translocation from the leaf to the roots.

  4. Links - SRSCRO

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > The EnergyCenter (LMI-EFRC) - CenterLinks Berkeley Lab Links:links

  5. Designing Biological Systems for Sustainability and Programmed Environmental Interface (2011 JGI User Meeting)

    ScienceCinema (OSTI)

    Silver, Pam [Harvard University

    2011-06-03T23:59:59.000Z

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Pam Silver of Harvard University gives a presentation on "Designing Biological Systems for Sustainability and Programmed Environmental Interface" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

  6. Designing Biological Systems for Sustainability and Programmed Environmental Interface (2011 JGI User Meeting)

    SciTech Connect (OSTI)

    Silver, Pam [Harvard University] [Harvard University

    2011-03-23T23:59:59.000Z

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Pam Silver of Harvard University gives a presentation on "Designing Biological Systems for Sustainability and Programmed Environmental Interface" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

  7. Systems biology analysis of Zymomonas mobilis ZM4 ethanol stress responses

    SciTech Connect (OSTI)

    Yang, Shihui [ORNL; Pan, Chongle [ORNL; Tschaplinski, Timothy J [ORNL; Hurst, Gregory {Greg} B [ORNL; Engle, Nancy L [ORNL; Zhou, Wen [University of Georgia, Athens, GA; Dam, Phuongan [ORNL; Xu, Ying [University of Georgia, Athens, GA; Dice, Lezlee T [ORNL; Davison, Brian H [ORNL; Brown, Steven D [ORNL

    2013-01-01T23:59:59.000Z

    Zymomonas mobilis ZM4 is a capable ethanogenic bacterium with high ethanol productivity and high level of ethanol tolerance. Previous studies indicated that several stress-related proteins and changes in the ZM4 membrane lipid composition may contribute to ethanol tolerance. However, the molecular mechanisms of ethanol stress response have not been elucidated fully. In this study, ethanol stress responses were investigated using systems biology tools. Medium supplementation with an initial 47.3 g/L (6% v/v) ethanol reduced Z. mobilis ZM4 glucose consumption, growth rate and ethanol productivity compared to that of untreated controls. Metabolomic profiling showed that ethanol-treated ZM4 cells accumulated greater amounts of glycerol during the entire fermentation process, which may indicate an important role for this metabolite. A proteomic analysis of early exponential growth identified about one thousand proteins, or approximately 56% of the predicted ZM4 proteome. Proteins related to metabolism and stress response such as chaperones and key regulators were more abundant in the early ethanol stress condition. Transcriptomic studies indicated the response of ZM4 to ethanol is dynamic, complex and involves many genes from all the different functional categories. There were fewer genes significantly differentially expressed in the exponential phase compared to that of stationary phase and early stationary phase. Most down-regulated genes were related to translation and ribosome biogenesis, while the ethanol-upregulated genes were mostly related to cellular processes and metabolism. Correlations among the transcriptomics, proteomics and metabolism were examined and among significantly expressed genes or proteins, we observe higher correlation coefficients when fold-change values are higher. This systems biology study elucidates key Z. mobilis ZM4 metabolites, genes and proteins that form the foundation of its distinctive physiology and its multifaceted response to ethanol stress.

  8. Systems Biology Analysis of Brucella Infected Peyers Patch Reveals Rapid Invasion with Modest Transient Perturbations of the Host Transcriptome

    E-Print Network [OSTI]

    Rossetti, Carlos A.; Drake, Kenneth L.; Siddavatam, Prasad; Lawhon, Sara D.; Nunes, Jairo E.; Gull, Tamara; Khare, Sangeeta; Everts, Robin E.; Lewin, Harris A.; Adams, Leslie Garry

    2013-12-09T23:59:59.000Z

    Systems Biology Analysis of Brucella Infected Peyer’s Patch Reveals Rapid Invasion with Modest Transient Perturbations of the Host Transcriptome Carlos A. Rossetti1¤a, Kenneth L. Drake2, Prasad Siddavatam2, Sara D. Lawhon1, Jairo E. S. Nunes1... mechanisms. Citation: Rossetti CA, Drake KL, Siddavatam P, Lawhon SD, Nunes JES, et al. (2013) Systems Biology Analysis of Brucella Infected Peyer’s Patch Reveals Rapid Invasion with Modest Transient Perturbations of the Host Transcriptome. PLoS ONE 8(12): e...

  9. On linking an Earth system model to the equilibrium carbon representation of an economically optimizing land use model

    SciTech Connect (OSTI)

    Bond-Lamberty, Benjamin; Calvin, Katherine V.; Jones, Andrew D.; Mao, Jiafu; Patel, Pralit L.; Shi, Xiaoying; Thomson, Allison M.; Thornton, Peter E.; Zhou, Yuyu

    2014-01-01T23:59:59.000Z

    Human activities are significantly altering biogeochemical cycles at the global scale, posing a significant problem for earth system models (ESMs), which may incorporate static land-use change inputs but do not actively simulate policy or economic forces. One option to address this problem is a to couple an ESM with an economically oriented integrated assessment model. Here we have implemented and tested a coupling mechanism between the carbon cycles of an ESM (CLM) and an integrated assessment (GCAM) model, examining the best proxy variables to share between the models, and quantifying our ability to distinguish climate- and land-use-driven flux changes. CLM’s net primary production and heterotrophic respiration outputs were found to be the most robust proxy variables by which to manipulate GCAM’s assumptions of long-term ecosystem steady state carbon, with short-term forest production strongly correlated with long-term biomass changes in climate-change model runs. By leveraging the fact that carbon-cycle effects of anthropogenic land-use change are short-term and spatially limited relative to widely distributed climate effects, we were able to distinguish these effects successfully in the model coupling, passing only the latter to GCAM. By allowing climate effects from a full earth system model to dynamically modulate the economic and policy decisions of an integrated assessment model, this work provides a foundation for linking these models in a robust and flexible framework capable of examining two-way interactions between human and earth system processes.

  10. Extracting information from biological networks

    E-Print Network [OSTI]

    Chindelevitch, Leonid Alexandrovich

    2010-01-01T23:59:59.000Z

    Systems biology, the study of biological systems in a holistic manner, has been catalyzed by a dramatic improvement in experimental techniques, coupled with a constantly increasing availability of biological data. The ...

  11. Efficiency, Robustness and Stochasticity of Gene Regulatory Networks in Systems Biology: lambda Switch as a Working Example

    E-Print Network [OSTI]

    X. Zhu; L. Yin; L. Hood; D. Galas; P. Ao

    2006-02-09T23:59:59.000Z

    Phage lambda is one of the most studied biological models in modern molecular biology. Over the past 50 years quantitative experimental knowledge on this biological model has been accumulated at all levels: physics, chemistry, genomics, proteomics, functions, and more. All its components have been known to a great detail. The theoretical task has been to integrate its components to make the organism working quantitatively in a harmonic manner. This would test our biological understanding and would lay a solid fundamental for further explorations and applications, an obvious goal of systems biology. One of the outstanding challenges in doing so has been the so-called stability puzzle of lambda switch: the biologically observed robustness and its difficult mathematical reconstruction based on known experimental values. In this chapter we review the recent theoretical and experimental efforts on tackling this problem. An emphasis is put on the minimum quantitative modeling where a successful numerical agreement between experiments and modeling has been achieved. A novel method tentatively named stochastic dynamical structure analysis emerged from such study is also discussed within a broad modeling perspective.

  12. Related Links

    Broader source: Energy.gov [DOE]

    The links below provide useful algae resources and are organized by categories. Beyond this page, learn more about BETO's Algae Program R&D by visiting the Information Resources page.

  13. A Comprehensive Collection of Systems Biology Data Characterizing the Host Response to Viral Infection

    SciTech Connect (OSTI)

    Aevermann, Brian; Pickett, Brett E.; Kumar, Sanjeev; Klem, Edward B.; Agnihothram, Sudhakar; Askovich, Peter S.; Bankhead, Armand; Bolles, Meagan; Carter, Victoria; Chang, Jean H.; Clauss, Therese RW; Dash, Pradyot; Diercks, Alan H.; Eisfeld, Amie J.; Ellis, Amy L.; Fan, Shufang; Ferris, Martin T.; Gralinski, Lisa; Green, Richard; Gritsenko, Marina A.; Hatta, Masato; Heegel, Robert A.; Jacobs, Jon M.; Jeng, Sophia; Josset, Laurence; Kaiser, Shari M.; Kelly, Sarah; Law, Gale L.; Li, Chengjun; Li, Jiangning; Long, Casey; Luna, Maria L.; Matzke, Melissa M.; McDermott, Jason E.; Menachery, Vineet; Metz, Thomas O.; Mitchell, Hugh D.; Monroe, Matthew E.; Navarro, Garnet; Neumann, Gabriele; Podyminogin, Rebecca L.; Purvine, Samuel O.; Rosenberger, Carrie; Sanders, Catherine J.; Schepmoes, Athena A.; Shukla, Anil K.; Sims, Amy; Sova, Pavel; Tam, Vincent C.; Tchitchek, Nicholas; Thomas, Paul G.; Tilton, Susan C.; Totura, Allison L.; Wang, Jing; Webb-Robertson, Bobbie-Jo M.; Wen, Ji; Weiss, Jeffrey M.; Yang, Feng; Yount, Boyd; Zhang, Qibin; Mcweeney, Shannon K.; Smith, Richard D.; Waters, Katrina M.; Kawaoka, Yoshihiro; Baric, Ralph; Aderem, Alan; Katze, Michael G.; Scheuermann, Richard H.

    2014-10-14T23:59:59.000Z

    The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), were investigated. Study validation was demonstrated via experimental quality control measures and meta-analysis of independent experiments performed under similar conditions. Primary assay results are archived at the GEO and PeptideAtlas public repositories, while processed statistical results together with standardized metadata are publically available at the Influenza Research Database (www.fludb.org) and the Virus Pathogen Resource (www.viprbrc.org). By comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection.

  14. Water Use in Agricultural Watersheds Derrel Martin, Professor, Irrigation and Water Resources Engineer, Dept. of Biological Systems

    E-Print Network [OSTI]

    Nebraska-Lincoln, University of

    Water Use in Agricultural Watersheds Derrel Martin, Professor, Irrigation and Water Resources Engineer, Dept. of Biological Systems Engineering, UNL Background Concerns about water use have intensified and Republican River Basins, and the implementation of LB 962. To understand water use it is helpful to consider

  15. S bi l f d h d dSystems biology software, data exchange standards and ontologies

    E-Print Network [OSTI]

    Rostock, Universität

    exchange formats o XML based standards o Standards for graphical representation 3. Ontologies (Gene formats o XML based standards o Standards for graphical representation 3. Ontologies (Gene Ontology) 4S bi l f d h d dSystems biology software, data exchange standards and ontologies Ulf Schmitz04 01

  16. Contributions to the Theory of Thermostated Systems II: Least Dissipation of Helmholtz Free Energy in Nano-Biology

    E-Print Network [OSTI]

    Ronald F. Fox

    2015-03-12T23:59:59.000Z

    In this paper, we develop further the theory of thermostated systems along the lines of our earlier paper. Two results are highlighted: 1) in the Markov limit of the contracted description, a least dissipation of Helmholtz free energy principle is established; and 2) a detailed account of the appropriateness of this principle for nano-biology, including the evolution of life, is presented.

  17. Contributions to the Theory of Thermostated Systems II: Least Dissipation of Helmholtz Free Energy in Nano-Biology

    E-Print Network [OSTI]

    Ronald F. Fox

    2015-03-11T23:59:59.000Z

    In this paper, we develop further the theory of thermostated systems along the lines of our earlier paper. Two results are highlighted: 1) in the Markov limit of the contracted description, a least dissipation of Helmholtz free energy principle is established; and 2) a detailed account of the appropriateness of this principle for nano-biology, including the evolution of life, is presented.

  18. Integrated Omics in Systems Biology: The New Frontier for Environmental Biotechnology

    E-Print Network [OSTI]

    Hazen, Terry C.

    2008-01-01T23:59:59.000Z

    biology Comparative Genomics Metabolomics DNA Microarraysand Environmental Research, Genomics Program:GTL throughINSTITUTE FOR ENVIRONMENTAL GENOMICS UNIVERSITY OF OKLAHOMA

  19. Cool Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisitingContract Management Fermi Site Office (FSO) FSOConverting Biomass toCool Links

  20. Related Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > TheNuclear Press Releases 2014References by Websitehome / Related Links

  1. Department of Energy's Biological and Environmental Research Strategic Data Roadmap for Earth System Science

    SciTech Connect (OSTI)

    Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Palanisamy, Giri [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shipman, Galen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Boden, Thomas A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Voyles, Jimmy W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-04-25T23:59:59.000Z

    Rapid advances in experimental, sensor, and computational technologies and techniques are driving exponential growth in the volume, acquisition rate, variety, and complexity of scientific data. This wealth of scientifically meaningful data has tremendous potential to lead to scientific discovery. However, to achieve scientific breakthroughs, these data must be exploitable—they must be analyzed effectively and efficiently and the results shared and communicated easily within the wider Department of Energy’s (DOE’s) Biological and Environmental Research (BER) Climate and Environmental Sciences Division (CESD) community. The explosion in data complexity and scale makes these tasks exceedingly difficult to achieve, particularly given that an increasing number of disciplines are working across techniques, integrating simulation and experimental or observational results (see Table 5 in Appendix 2). Consequently, we need new approaches to data management, analysis, and visualization that provide research teams with easy-to-use and scalable end-to-end solutions. These solutions must facilitate (and where feasible, automate and capture) every stage in the data lifecycle (shown in Figure 1), from collection to management, annotation, sharing, discovery, analysis, and visualization. In addition, the core functionalities are the same across climate science communities, but they require customization to adapt to specific needs and fit into research and analysis workflows. To this end, the mission of CESD’s Data and Informatics Program is to integrate all existing and future distributed CESD data holdings into a seamless and unified environment for the acceleration of Earth system science.

  2. System and method for preconcentrating, identifying, and quantifying chemical and biological substances

    DOE Patents [OSTI]

    Yu, Conrad M. (Antioch, CA); Koo, Jackson C. (San Ramon, CA)

    2000-01-01T23:59:59.000Z

    A system and method for preconcentrating, identifying, and quantifying chemical and biological substances is disclosed. An input valve directs a first volume of a sample gas to a surface acoustic wave (SAW) device. The SAW device preconcentrates and detects a mass of a substance within the sample gas. An output valve receives a second volume of the sample gas containing the preconcentrated substance from the SAW device and directs the second volume to a gas chromatograph (GC). The GC identifies the preconcentrated substance within the sample gas. A shunt valve exhausts a volume of the sample gas equal to the first volume minus the second volume away from the SAW device and the GC. The method of the present invention includes the steps of opening an input valve for passing a first volume of a sample gas to a SAW device; preconcentrating and detecting a mass of a substance within the sample gas using the SAW device; opening an output valve for passing a second volume of the sample gas containing the preconcentrated substance to a gas chromatograph (GC); and then identifying the preconcentrated substance within the sample gas using the GC.

  3. New wholesale power market design using linked forward markets : a study for the DOE energy storage systems program.

    SciTech Connect (OSTI)

    Silva Monroy, Cesar Augusto; Loose, Verne William; Ellison, James F.; Elliott, Ryan Thomas; Byrne, Raymond Harry; Guttromson, Ross; Tesfatsion, Leigh S. [Iowa State University, Ames, IA

    2013-04-01T23:59:59.000Z

    This report proposes a reformulation of U.S. ISO/RTO-managed wholesale electric power mar- kets for improved reliability and e ciency of system operations. Current markets do not specify or compensate primary frequency response. They also unnecessarily limit the participation of new technologies in reserve markets and o er insu cient economic inducements for new capacity invest- ment. In the proposed market reformulation, energy products are represented as physically-covered rm contracts and reserve products as physically-covered call option contracts. Trading of these products is supported by a backbone of linked ISO/RTO-managed forward markets with planning horizons ranging from multiple years to minutes ahead. A principal advantage of this reformulation is that reserve needs can be speci ed in detail, and resources can o er the services for which they are best suited, without being forced to conform to rigid reserve product de nitions. This should improve the business case for electric energy storage and other emerging technologies to provide reserve. In addition, the facilitation of price discovery should help to ensure e cient energy/reserve procurement and adequate levels of new capacity investment.

  4. 2003 Synthetic Biology study

    E-Print Network [OSTI]

    Endy, Drew

    2007-08-14T23:59:59.000Z

    Biology is a technology for processing information, materials, and energy. As a technology platform, biological systems provide access to artifacts and processes across a range of scales (e.g., the ribosome is a programmable ...

  5. In vivo robotics: the automation of neuroscience and other intact-system biological fields

    E-Print Network [OSTI]

    Forest, Craig R.

    Robotic and automation technologies have played a huge role in in vitro biological science, having proved critical for scientific endeavors such as genome sequencing and high-throughput screening. Robotic and automation ...

  6. Physical, Chemical & Biological Processes of the Environment A Systems Approach to Solving Environmental Problems

    E-Print Network [OSTI]

    drilling for oil in the Great Lakes or Is fracking an environmental risk? 16 3 Biological sciences, pathogens, road salt or lead in drinking water. 22 17 Physical sciences: Water cycle and hydrology. 23 19

  7. A quantitative framework For large-scale model estimation and discrimination In systems biology

    E-Print Network [OSTI]

    Eydgahi, Hoda

    2013-01-01T23:59:59.000Z

    Using models to simulate and analyze biological networks requires principled approaches to parameter estimation and model discrimination. We use Bayesian and Monte Carlo methods to recover the full probability distributions ...

  8. Development and evaluation of a lignite-stillage carrier system for application and study of biological control agents 

    E-Print Network [OSTI]

    Jones, Richard Worth

    1983-01-01T23:59:59.000Z

    Approved as to style and content by: (Chairman of Committee) (Member) (Member) (Head of Department) December 1983 ABSTRACT Development and Evaluation of a Lignite-Sti liege Carrier System for Application and Study of Biological Agents. (December 1983.... The carrier system consisted of lignite granules amended with thin liquid sti llage. This carrier system supported fungal propagule production as high as 2. 0 x 10g propagules/g carrier. Thin liquid sti llage supported the production of 4. 0-4. 5 mg of g...

  9. 2003: Energy performance of daylight-linked automatic lighting control systems in large atrium spaces: report on two field-monitored case studies

    E-Print Network [OSTI]

    M. R. Galasiu; Morad R. Atif; Anca D. Galasiu

    This paper presents the field-measured energy performance of two common types of daylight-linked lighting control systems, continuous dimming and automatic on/off installed in two existing large atrium spaces located in Canada. The daylighting performance was evaluated based on the daylight contribution to the indoor illuminance and the amount of electrical lighting displaced by daylighting via the daylight-linked lighting control systems. Measured daylighting contribution to the space indicates that significant lighting energy savings can be achieved in atrium spaces if the daylight-linked lighting control system is appropriately selected, installed and commissioned throughout its existence. Results extrapolated from measurements collected during summer and winter indicate that as installed, the continuous dimming lighting control system provides 46% annual savings in electrical lighting consumption, while the automatic on/off saves between 11-17% in lighting energy. These savings account for 68% of the lighting energy consumed during main occupancy for the continuous dimming system, and 31.5% for the automatic on/off. Operation irregularities such as a reduced dimming linearity and an incorrect adjustment of the phases of the dimming control system, as well as the inadequate location of the photocell controlling the automatic on/off lighting system, the improper maintenance of the skylight during winter and the oversizing of the lighting system reduced the energy efficiency of the lighting control systems by 30-65%.

  10. Relevant Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > TheNuclear Press Releases 2014References by Websitehome / Related

  11. Training Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesisAppliances » TopTours SignTrackingTraining

  12. MIDC: Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn12electron 9November 6, In this3,OfficeWITH AT65-OCT. 5,

  13. MSDS Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |IsLove Your Home and It'll Love YouTokamak |MPC EquipmentGlossary

  14. HELPFUL LINKS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonic Engine GyroSolé(tm)HDFView HDFView

  15. Faculty Links - Links - Cyclotron Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget » FY 2014FacilitiesSheet 300Office

  16. Artist Camille Utterback's interactive installations and reactive sculptures explore the possibilities of linking computational systems to human movement and gesture in layered and playful ways. Her work

    E-Print Network [OSTI]

    Gilchrist, James F.

    Artist Camille Utterback's interactive installations and reactive sculptures explore of a poem. In the External Measures series (2001­2007) a set of dynamic interactive drawings links past across disciplines. What is the balance between clarity and complexity that makes an interactive system

  17. Computational Biology & Bioinformatics

    E-Print Network [OSTI]

    Johnson, Marcia K.

    Computational Biology & Bioinformatics at Yale An Interdepartmental PhD Program and a Track within://www.yale.edu/graduateschool/admissions/apply_online.html 2 #12;Introduction Computational Biology and Bioinformatics (CBB) is a rapidly developing multi experimentation. Computational and theoretical approaches to understanding biological systems provide an essential

  18. Computational Biology & Bioinformatics

    E-Print Network [OSTI]

    Computational Biology & Bioinformatics at Yale An Interdepartmental PhD Program and a Track within://www.yale.edu/graduateschool/admissions/apply_online.html #12;3 Introduction Computational Biology and Bioinformatics (CBB) is a rapidly developing multi experimentation. Computational and theoretical approaches to understanding biological systems provide an essential

  19. A recent study of meteorological conditions around the Pentagon will support development of a system to protect its 25,000+ occupants from chemical, biological, and radiological attack.

    E-Print Network [OSTI]

    Knievel, Jason Clark

    of a system to protect its 25,000+ occupants from chemical, biological, and radiological attack. I nFEBRUARY 2007AMERICAN METEOROLOGICAL SOCIETY | #12;of the most likely targets for a future terrorist attack

  20. Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB) and Department of Plant Biotechnology and Genetics, Ghent University, Gent, Belgium.

    E-Print Network [OSTI]

    Cai, Long

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB) and Department of Plant Biotechnology and Genetics, Ghent University, Gent, Belgium. Correspondence should be addressed or rapidly escape from adverse environmental situations. To overcome these restrictions, plants have evolved

  1. Method and apparatus for routing data in an inter-nodal communications lattice of a massively parallel computer system by dynamic global mapping of contended links

    DOE Patents [OSTI]

    Archer, Charles Jens (Rochester, MN); Musselman, Roy Glenn (Rochester, MN); Peters, Amanda (Rochester, MN); Pinnow, Kurt Walter (Rochester, MN); Swartz, Brent Allen (Chippewa Falls, WI); Wallenfelt, Brian Paul (Eden Prairie, MN)

    2011-10-04T23:59:59.000Z

    A massively parallel nodal computer system periodically collects and broadcasts usage data for an internal communications network. A node sending data over the network makes a global routing determination using the network usage data. Preferably, network usage data comprises an N-bit usage value for each output buffer associated with a network link. An optimum routing is determined by summing the N-bit values associated with each link through which a data packet must pass, and comparing the sums associated with different possible routes.

  2. Verification test problems for the calculation of probability of loss of assured safety in temperature-dependent systems with multiple weak and strong links.

    SciTech Connect (OSTI)

    Johnson, Jay Dean (ProStat, Mesa, AZ); Oberkampf, William Louis; Helton, Jon Craig (Arizona State University, Tempe, AZ)

    2006-06-01T23:59:59.000Z

    Four verification test problems are presented for checking the conceptual development and computational implementation of calculations to determine the probability of loss of assured safety (PLOAS) in temperature-dependent systems with multiple weak links (WLs) and strong links (SLs). The problems are designed to test results obtained with the following definitions of loss of assured safety: (1) Failure of all SLs before failure of any WL, (2) Failure of any SL before failure of any WL, (3) Failure of all SLs before failure of all WLs, and (4) Failure of any SL before failure of all WLs. The test problems are based on assuming the same failure properties for all links, which results in problems that have the desirable properties of fully exercising the numerical integration procedures required in the evaluation of PLOAS and also possessing simple algebraic representations for PLOAS that can be used for verification of the analysis.

  3. Growth control of the eukaryote cell: A systems biology study in yeast

    E-Print Network [OSTI]

    Castrillo, Juan I; Zeef, Leo A; Hoyle, David C; Zhang, Nianshu; Hayes, Andrew; Gardner, David C J; Cornell, Michael J; Petty, June; Hakes, Luke; Wardleworth, Leanne; Rash, Bharat; Brown, Marie; Dunn, Warwick B; Broadhurst, David; O'Donoghue, Kerry; Hester, Svenja S; Dunkley, Tom P J; Hart, Sarah; Swainston, Neil; Li, Peter; Gaskell, Simon J; Paton, Norman W; Lilley, Kathryn S; Kell, Douglas B; Oliver, Stephen G

    2007-04-30T23:59:59.000Z

    -line. At appropriate intervals, culture samples were collected for determination of biomass concentration. Biomass levels were monitored both spectrophotometrically at a wavelength of 600 nm, and by dry weight. Dry weight measurements were determined as described... , corresponding to the biological process: tRNA aminoacylation for protein translation (GO tool: GenMAPP). Colour code as in Fig. S17. Fig. S20. Storage vacuole. Groups of genes significantly up-regulated and down-regulated corresponding to the cellular...

  4. Cryoelectron Microscopy as a Functional Instrument for Systems Biology, Structural Analysis & Experimental Manipulations with Living Cells. A comprehensive review of the current works

    E-Print Network [OSTI]

    Gradov, Oleg V

    2015-01-01T23:59:59.000Z

    The aim of this paper is to give an introductory review of the cryoelectron microscopy as a complex data source for the most of the system biology branches, including the most perspective non-local approaches known as "localomics" and "dynamomics". A brief summary of various cryoelectron mi-croscopy methods and corresponding system biological ap-proaches is given in the text. The above classification can be considered as a useful framework for the primary comprehen-sions about cryoelectron microscopy aims and instrumental tools. We do not discuss any of these concepts in details, but merely point out that their methodological complexity follows only from the structure-functional complexity of biological systems which are investigated in this manner. We also postu-late that one can employ some of the cryoelectron microscopic techniques not only for observation, but also for modification and structural refunctionalization of some biological and similar soft matter objects and microscopic samples. In other world...

  5. Putting in perspective human-machine system theory and modeling: from theoretical biology to artifacts

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    there is a strong need of reliability and consistency from modeling, development and life cycle systems. A main and organization from human-machine systems to socio- technical systems especially for safety and life critical methodologies and ergonomics of systems design. Current and future technical developments for enhancing human

  6. Development and Applications Of Photosensitive Device Systems To Studies Of Biological And Organic Materials

    SciTech Connect (OSTI)

    Gruner, Sol

    2012-01-20T23:59:59.000Z

    The primary focus of the grant is the development of new x-ray detectors for biological and materials work at synchrotron sources, especially Pixel Array Detectors (PADs), and the training of students via research applications to problems in biophysics and materials science using novel x-ray methods. This Final Progress Report provides a high-level overview of the most important accomplishments. These major areas of accomplishment include: (1) Development and application of x-ray Pixel Array Detectors; (2) Development and application of methods of high pressure x-ray crystallography as applied to proteins; (3) Studies on the synthesis and structure of novel mesophase materials derived from block co-polymers.

  7. Abdou-Arbi et al. BMC Systems Biology 2014, 8:8 http://www.biomedcentral.com/1752-0509/8/8

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Abdou-Arbi et al. BMC Systems Biology 2014, 8:8 http://www.biomedcentral.com/1752 study of precursor sets for system outputs Oumarou Abdou-Arbi1,2,3, Sophie Lemosquet4,5, Jaap Van Milgen information [2]. With a complementary approach, one © 2014 Abdou-Arbi et al.; licensee BioMed Central Ltd

  8. Electro-mechanical energy conversion system having a permanent magnet machine with stator, resonant transfer link and energy converter controls

    DOE Patents [OSTI]

    Skeist, S. Merrill; Baker, Richard H.

    2006-01-10T23:59:59.000Z

    An electro-mechanical energy conversion system coupled between an energy source and an energy load comprising an energy converter device including a permanent magnet induction machine coupled between the energy source and the energy load to convert the energy from the energy source and to transfer the converted energy to the energy load and an energy transfer multiplexer to control the flow of power or energy through the permanent magnetic induction machine.

  9. Protein-Folding Landscapes in Multi-Chain Systems Major Classification: Biological Sciences

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem Not Found Item Not Foundenhancer activity than histone30518theProtein-Folding

  10. K. A. Garrett and C. M. Cox. Applied biodiversity science: Managing emerging diseases in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease ecology: The effects of ecosystems on disease and of disease

    E-Print Network [OSTI]

    Garrett, Karen A.

    in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease in Agriculture and Linked Natural Systems Using Ecological Principles K. A. Garrett and C. M. Cox Summary particular crop species or genotypes are very common. Nonetheless, production agriculture is dominated

  11. Integrated Omics in Systems Biology: The New Frontier for Environmental Biotechnology

    SciTech Connect (OSTI)

    Hazen, Terry C.

    2008-08-12T23:59:59.000Z

    Environmental biotechnology encompasses a wide range of characterization, monitoring and control for bioenergy and bioremediation technologies that are based on biological processes. Recent breakthroughs in our understanding of biogeochemical processes and genomics are leading to exciting new and cost effective ways to monitor and manipulate the environment and potentially produce bioenergy fuels as we also cleanup the environment. Indeed, our ability to sequence an entire microbial genome in just a few hours is leading to similar breakthroughs in characterizing proteomes, metabolomes, phenotypes, and fluxes for organisms, populations, and communities. Understanding and modeling functional microbial community structure and stress responses in subsurface environments has tremendous implications for our fundamental understanding of biogeochemistry and the potential for making biofuel breakthroughs. Monitoring techniques that inventory and monitor terminal electron acceptors and electron donors, enzyme probes that measure functional activity in the environment, functional genomic microarrays, phylogenetic microarrays, metabolomics, proteomics, and quantitative PCR are also being rapidly adapted for studies in environmental biotechnology. Integration of all of these new high throughput techniques using the latest advances in bioinformatics and modeling will enable break-through science in environmental biotechnology. A review of these techniques with examples from field studies and lab simulations will be discussed.

  12. Cryoelectron Microscopy as a Functional Instrument for Systems Biology, Structural Analysis & Experimental Manipulations with Living Cells. A comprehensive review of the current works

    E-Print Network [OSTI]

    Oleg V. Gradov; Margaret A. Gradova

    2015-01-18T23:59:59.000Z

    The aim of this paper is to give an introductory review of the cryoelectron microscopy as a complex data source for the most of the system biology branches, including the most perspective non-local approaches known as "localomics" and "dynamomics". A brief summary of various cryoelectron mi-croscopy methods and corresponding system biological ap-proaches is given in the text. The above classification can be considered as a useful framework for the primary comprehen-sions about cryoelectron microscopy aims and instrumental tools. We do not discuss any of these concepts in details, but merely point out that their methodological complexity follows only from the structure-functional complexity of biological systems which are investigated in this manner. We also postu-late that one can employ some of the cryoelectron microscopic techniques not only for observation, but also for modification and structural refunctionalization of some biological and similar soft matter objects and microscopic samples. In other worlds, we start with the cryoelectron microscopy as a tool for the sys-tem biology and progress to its applying as an instrument for system biology and functional biomimetics; i.e. "system cryobi-ology" goes over into "synthetic cryobiology" or "cryogenic biomimetics". All these conclusions can be deduced from the most recent works of the latest years, including just submitted foreign papers. This article provides an up-to-date description of the conceptual basis for the novel view on the computational cryoelectron microscopy (in silico) approaches and the data mining principles which lie at the very foundation of modern structural analysis and reconstruction.

  13. Faculty Expertise Index Advanced Artificial Intelligence, Technology, & Control Systems Development for Biological &

    E-Print Network [OSTI]

    Amin, S. Massoud

    Faculty Expertise Index Advanced Artificial Intelligence, Technology, & Control Systems Development-Paul Schirle-Keller Food Additives ­ Artificial Sweeteners ­ Ted Labuza Food Analysis Chromatographic Processing (see Phytochemicals, Advanced Artificial Intelligence) Canning Technology ­ Ted Labuza Cheese

  14. Biological and environmental efficiency of high producing dairy systems through application of life cycle analysis 

    E-Print Network [OSTI]

    Ross, Stephen Alexander

    2014-11-27T23:59:59.000Z

    Dairy production systems are an important global contributor to anthropogenic greenhouse gas (GHG) emissions including methane (CH4), nitrous oxide (N2O) and carbon dioxide (CO2). Due to the role GHG play in climate ...

  15. Please cite this article in press as: Baumbach, J. et al., CoryneRegNet 3.0--An interactive systems biology plat-form for the analysis of gene regulatory networks in corynebacteria and Escherichia coli, J. Biotechnol. (2007),

    E-Print Network [OSTI]

    Babu, M. Madan

    2007-01-01T23:59:59.000Z

    Please cite this article in press as: Baumbach, J. et al., CoryneRegNet 3.0--An interactive systems of Biotechnology xxx (2007) xxx­xxx CoryneRegNet 3.0--An interactive systems biology platform for the analysis., CoryneRegNet 3.0--An interactive systems biology plat- form for the analysis of gene regulatory networks

  16. Protective link for superconducting coil

    DOE Patents [OSTI]

    Umans, Stephen D. (Belmont, MA)

    2009-12-08T23:59:59.000Z

    A superconducting coil system includes a superconducting coil and a protective link of superconducting material coupled to the superconducting coil. A rotating machine includes first and second coils and a protective link of superconducting material. The second coil is operable to rotate with respect to the first coil. One of the first and second coils is a superconducting coil. The protective link is coupled to the superconducting coil.

  17. Active dc filter for HVDC system--A test installation in the Konti-Skan DC link at Lindome converter station

    SciTech Connect (OSTI)

    Zhang, Wenyan; Asplund, G. (ABB Power Systems, Ludvika (Sweden). HVDC Division); Aberg, A. (ABB Corporate Research, Lund (Sweden). Dept. of Man-Machine Communication); Jonsson, U. (Svenska Kraftnaet, Vaellingby (Sweden)); Loeoef, O. (Vattenfall AB, Trollhaettan (Sweden). Region Vaestsverige)

    1993-07-01T23:59:59.000Z

    The purpose of introducing active dc filters is to meet the more and more stringent requirement from power utilities on limiting telephone interference caused by harmonic currents from HVdc transmission lines, without unnecessarily increasing the cost of HVdc stations. An active dc filter installed in the Konti-Skan HVdc link is described. The active dc filter is connected at the bottom of an existing passive dc filter at the Lindome station. The active dc filter includes optic harmonic current measuring unit, control system, protection and supervision system, PWM power amplifier, high-frequency transformer, surge arrester, and coupling apparatuses. The active dc filter has small physical size and occupies small ground area. The performance of the active dc filter for eliminating the disturbing harmonics is excellent. To achieve comparable results by passive filters would require something like ten times more high voltage equipment.

  18. AGRICULTURAL AND BIOLOGICAL

    E-Print Network [OSTI]

    Gilbert, Matthew

    AGRICULTURAL AND BIOLOGICAL ENGINEERING UNDERGRADUATE PROGRAM Prepare... yourself for a career in integrating life and engineering for systems in agriculture, food, environment, and energy, and to contribute to the world's largest industry. COLLEGE OF ACES COLLEGE OF ENGINEERING #12;AGRICULTURAL AND BIOLOGICAL

  19. Systems Biology Model of Interactions Between Tissue Growth Factors and DNA Damage Pathways: Low Dose Response and Cross-Talk in TGFbeta and ATM Signaling

    SciTech Connect (OSTI)

    O'Neill, Peter [University of Oxford; Anderson, Jennifer [University of Oxford

    2014-10-02T23:59:59.000Z

    The etiology of radiation carcinogenesis has been described in terms of aberrant changes that span several levels of biological organization. Growth factors regulate many important cellular and tissue functions including apoptosis, differentiation and proliferation. A variety of genetic and epigenetic changes of growth factors have been shown to contribute to cancer initiation and progression. It is known that cellular and tissue damage to ionizing radiation is in part initiated by the production of reactive oxygen species, which can activate cytokine signaling, and the DNA damage response pathways, most notably the ATM signaling pathway. Recently the transforming growth factor ? (TGF?) pathway has been shown to regulate or directly interact with the ATM pathway in the response to radiation. The relevance of this interaction with the ATM pathway is not known although p53 becomes phosphorylated and DNA damage responses are involved. However, growth factor interactions with DNA damage responses have not been elucidated particularly at low doses and further characterization of their relationship to cancer processes is warranted. Our goal will be to use a systems biology approach to mathematically and experimentally describe the low dose responses and cross-talk between the ATM and TGF? pathways initiated by low and high LET radiation. We will characterize ATM and TGF? signaling in epithelial and fibroblast cells using 2D models and ultimately extending to 3D organotypic cell culture models to begin to elucidate possible differences that may occur for different cell types and/or inter-cellular communication. We will investigate the roles of the Smad and Activating transcription factor 2 (ATF2) proteins as the potential major contributors to cross- talk between the TGF? and ATM pathways, and links to cell cycle control and/or the DNA damage response, and potential differences in their responses at low and high doses. We have developed various experimental approaches to apply to these problems using confocal microscopy and flow cytometry to detail changes at low dose/dose-rate in order to understand individual cell responses, and will establish our mathematical models based on the experimental findings resulting from changes in DNA repair, apoptosis and proliferation.

  20. NATIONAL CENTRE FOR BIOLOGICAL SCIENCES Annual Maintenance Contract for Electrical Systems in

    E-Print Network [OSTI]

    Udgaonkar, Jayant B.

    Maintenance Contract for Electrical systems including substations in Mandara hostel-CB site, NCBS : Rs.47,729.00 4. COST OF TENDER DOCUMENT : Rs. 500/- 5. SALE PERIOD : 13/12/2013 TO 23/12/2013 6. TIME:________________DATE:____________ __________________________________ FOR A SUM OF RS. ________________ TOWARDS __________________________________THE COST OF TENDER DOCUMENT

  1. Systems Biology Approaches to Dissecting Plant Cell Wall Biosynthesis Genes in Poplus (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    ScienceCinema (OSTI)

    Glass, N Louise [UC Berkeley

    2013-01-25T23:59:59.000Z

    N. Louise Glass from the University of California, Berkeley, presents a talk titled "Systems Biology Approaches to Dissecting Plant Cell Wall Biosynthesis Genes in Poplus" at the JGI 7th Annual Users Meeting: Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, California.

  2. ENGINEERING GRaduatE PRoGRams Biological SyStemS engineering Biomedical engineering chemical engineering civil and environmental engineering

    E-Print Network [OSTI]

    California at Davis, University of

    ENGINEERING GRaduatE PRoGRams Biological SyStemS engineering § Biomedical engineering § chemical engineering § civil and environmental engineering computer Science § electrical and computer engineering § materialS Science and engineering mechanical and aeronautical engineering § tranSportation technology

  3. Systems Biology Approaches to Dissecting Plant Cell Wall Biosynthesis Genes in Poplus (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    SciTech Connect (OSTI)

    Glass, N Louise [UC Berkeley] [UC Berkeley

    2012-03-22T23:59:59.000Z

    N. Louise Glass from the University of California, Berkeley, presents a talk titled "Systems Biology Approaches to Dissecting Plant Cell Wall Biosynthesis Genes in Poplus" at the JGI 7th Annual Users Meeting: Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, California.

  4. Biology and management of insect pests in North American intensively managed hardwood forest systems.

    SciTech Connect (OSTI)

    Coyle, David R.; Nebeker, T., E.; Hart, E., R.; Mattson, W., J.

    2005-01-01T23:59:59.000Z

    Annu. Rev. Entomol. 50:1-29. Abstract Increasing demand for wood and wood products is putting stress on traditional forest production areas, leading to long-term economic and environmental concerns. Intensively managed hardwood forest systems (IMHFS), grown using conventional agricultural as well as forestry methods, can help alleviate potential problems in natural forest production areas. Although IMHFS can produce more biomass per hectare per year than natural forests, the ecologically simplified, monocultural systems may greatly increase the crops susceptibility to pests. Species in the genera Populus and Salix comprise the greatest acreage in IMHFS in North America, but other species, including Liquidambar styracifua and Platanus occidentalis, are also important. We discuss life histories, realized and potential damage, and management options for the most economically infuential pests that affect these hardwood species. The substantial inherent challenges associated with pest management in the monocultural environments created by IMHFS are reviewed. Finally, we discuss ways to design IMHFS that may reduce their susceptibility to pests, increase their growth and productivity potential, and create a more sustainable environment.

  5. Biological Interactions and Dynamics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    proactive "EMSL 2.0-style" research paradigm. Because of the rapid pace of modern genomics and systems biology research, it is necessary to respond rapidly and flexibly to...

  6. Self-referencing cellular automata: A model of the evolution of information control in biological systems

    E-Print Network [OSTI]

    Theodore P. Pavlic; Alyssa M. Adams; Paul C. W. Davies; Sara Imari Walker

    2014-05-16T23:59:59.000Z

    Cellular automata have been useful artificial models for exploring how relatively simple rules combined with spatial memory can give rise to complex emergent patterns. Moreover, studying the dynamics of how rules emerge under artificial selection for function has recently become a powerful tool for understanding how evolution can innovate within its genetic rule space. However, conventional cellular automata lack the kind of state feedback that is surely present in natural evolving systems. Each new generation of a population leaves an indelible mark on its environment and thus affects the selective pressures that shape future generations of that population. To model this phenomenon, we have augmented traditional cellular automata with state-dependent feedback. Rather than generating automata executions from an initial condition and a static rule, we introduce mappings which generate iteration rules from the cellular automaton itself. We show that these new automata contain disconnected regions which locally act like conventional automata, thus encapsulating multiple functions into one structure. Consequently, we have provided a new model for processes like cell differentiation. Finally, by studying the size of these regions, we provide additional evidence that the dynamics of self-reference may be critical to understanding the evolution of natural language. In particular, the rules of elementary cellular automata appear to be distributed in the same way as words in the corpus of a natural language.

  7. Geothermal: Related Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Related Links Geothermal Technologies Legacy Collection HelpFAQ | Site Map | Contact Us HomeBasic Search About Publications Advanced Search New Hot Docs News Related Links...

  8. Forging the Link: Linking the Economic Incentives

    E-Print Network [OSTI]

    Forging the Link: Linking the Economic Incentives of Low Impact Development with Community on the economic incentives of LID to address the local decisional realities of community watershed protection in nature but details the economic incentives to LID. It is best suited for audiences seeking to understand

  9. Biological Safety

    Broader source: Energy.gov [DOE]

    The DOE's Biological Safety Program provides a forum for the exchange of best practices, lessons learned, and guidance in the area of biological safety. This content is supported by the Biosurety Executive Team. The Biosurety Executive Team is a DOE-chartered group. The DOE Office of Worker Safety and Health Policy provides administrative support for this group. The group identifies biological safety-related issues of concern to the DOE and pursues solutions to issues identified.

  10. FRAMES-2.0 Software System: Linking to the Groundwater Modeling System (GMS) RT3D and MT3DMS Models

    SciTech Connect (OSTI)

    Whelan, Gene; Castleton, Karl J.; Pelton, Mitch A.

    2007-08-08T23:59:59.000Z

    Linkages to the Groundwater Modeling System have been developed at Pacific Northwest National Laboratory to enable the Nuclear Regulatory Commission (NRC) to more realistically assess the risk to the public of radioactive contaminants at NRC-licensed sites. Common software tools presently in use are limited in that they cannot assess contaminant migration through complex natural environments. The purpose of this initiative is to provide NRC with a licensing safety-analysis tool with sufficient power, flexibility, and utility that it can serve as the primary software platform for analyzing the hazards associated with licensing actions at those “complex” sites at which the traditional tools are inappropriate. As a tool designed to realistically approximate prospective doses to the public, this initiative addresses NRC’s safety-performance goal by confirming that licensing actions do not result in undue risk to the public.

  11. Development of an Implementation Plan Related to Biological Opinion on Operation of the Federal Columbia River Power System ; Step 1: Review and Critique of Implementation Plans.

    SciTech Connect (OSTI)

    Neitzel, Duane A.; Bunn, Amoret

    2000-12-01T23:59:59.000Z

    The Draft Biological Opinion on Operation of the Federal Columbia River Power System calls for the development of 1- and 5-year implementation plans. These plans will provide the roadmap for planning and subsequent implementation of actions intended to meet specific performance standards (i.e., biological objectives) in a timely manner. To develop implementation plans the key tasks and sequences of steps must be determined. Those responsible for specific tasks must be identified and they must understand what they need to do. There must be assurances that the resources (human, physical, and fiscal) to complete the tasks are available. Motivation and incentive systems should be set up. Systems to coordinate efforts and guide activity must be devised and installed. An information management system must be designed to manage and analyze data and ensure that appropriate data are collected. This will aid managers in assessing whether individual activities or actions are tracking with stated goals and objectives. Training programs to improve managerial and worker capability in making and implementing plans should be designed. Managerial leadership to guide the efforts of all individuals in achieving the goals of the anadromous and resident fish recovery must be developed. It is the entire process of managing fish recovery in relationship to the Biological Opinion that will guide, coordinate, motivate, and control work and determine the effectiveness and efficiency of plan implementation.

  12. Biological Systems Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Spectral induced polarization of hydroxide adsorption and mineral precipitation in porous media. Environ. Sci. Technol. doi: 10.1021es204404e. Gebrehiwet, T., Redden, G.D.,...

  13. Circumpolar Arctic Tundra Vegetation Change Is Linked

    E-Print Network [OSTI]

    Bhatt, Uma

    of Plant Biology, Michigan State University, East Lansing, Michigan Received 7 December 2009; accepted 4Circumpolar Arctic Tundra Vegetation Change Is Linked to Sea Ice Decline Uma S. Bhatt*,1 Donald A Institute, and Department of Atmospheric Sciences, University of Alaska Fairbanks, Fairbanks, Alaska

  14. Ising-link Quantum Gravity

    E-Print Network [OSTI]

    Tom Fleming; Mark Gross; Ray Renken

    1994-01-04T23:59:59.000Z

    We define a simplified version of Regge quantum gravity where the link lengths can take on only two possible values, both always compatible with the triangle inequalities. This is therefore equivalent to a model of Ising spins living on the links of a regular lattice with somewhat complicated, yet local interactions. The measure corresponds to the natural sum over all 2^links configurations, and numerical simulations can be efficiently implemented by means of look-up tables. In three dimensions we find a peak in the ``curvature susceptibility'' which grows with increasing system size. However, the value of the corresponding critical exponent as well as the behavior of the curvature at the transition differ from that found by Hamber and Williams for the Regge theory with continuously varying link lengths.

  15. Biological Science | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels Data Center HomeIdleBiological Science Biological Science The protozoan

  16. REVIEW: PART OF A SPECIAL ISSUE ON POPULATION BIOLOGY Pollination patterns and plant breeding systems in the Galapagos: a review

    E-Print Network [OSTI]

    Traveset, Anna

    has so far limited our predictive power on the consequences of the increasing threat of introducedREVIEW: PART OF A SPECIAL ISSUE ON POPULATION BIOLOGY Pollination patterns and plant breeding an important service to both plants and their pollinators. The rather modest level of knowledge on this subject

  17. Reducing Mortality from Terrorist Releases of Chemical and Biological Agents: I. Filtration for Ventilation Systems in Commercial Building

    E-Print Network [OSTI]

    Thatcher, Tracy L.

    2011-01-01T23:59:59.000Z

    Filtration for Ventilation Systems in Commercial BuildingsFiltration for Ventilation Systems in Commercial Buildingsbuilding's mechanical ventilation system and by infiltration

  18. Hydrogen Storage Related Links

    Broader source: Energy.gov [DOE]

    The following resources provide details about DOE-funded hydrogen storage activities, research plans and roadmaps, models and tools, and additional related links.

  19. SetLink the CERN Document Server Link Manager

    E-Print Network [OSTI]

    Le Meur, Jean-Yves

    2000-01-01T23:59:59.000Z

    This paper analyses the problems encountered by electronic libraries to cope with long term keeping of on-line documents. What is thebest solution not to fill in a library system with non persistent addresses ? Different possible solutions are studied, based on theexperience of the CERN Document Server and its library. This paper will stress the importance of using a Link Manager for any long term Web server. It will explain how the CERN SetLink Link Manager is designed to handle a wide range of document types and formats, from photos in JPEG to eprints in PDF. It will also focus onother possibilities offered by using such an application, like automatic figures extraction or concatenation, full text searching andon-the-fly format conversions.

  20. What is Systems Biology? Computational Biology Laboratory

    E-Print Network [OSTI]

    Lee, H.C. Paul

    of high-throughput experimental techniques ­ micro-array (1995), mass spectrometry of proteins (1987), 2D* Proteins, energy, functions, etc. Building Blueprint Machines & workers Energy & supplies Physical plant ­gene-disruption data ·(protein­protein interaction) yeast two- hybrid data ·Many high-throughput exp

  1. Biological preconcentrator

    DOE Patents [OSTI]

    Manginell, Ronald P. (Albuquerque, NM); Bunker, Bruce C. (Albuquerque, NM); Huber, Dale L. (Albuquerque, NM)

    2008-09-09T23:59:59.000Z

    A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

  2. What rough beast? Synthetic Biology and the Future of Biosecurity

    E-Print Network [OSTI]

    Mohr, Scott C.

    Synthetic biology seeks to create modular biological parts that can be assembled into useful devices, allowing the modification of biological systems with greater reliability, at lower cost, with greater speed, and by a ...

  3. New Optical Link Technologies for HEP Experiments

    E-Print Network [OSTI]

    P. Delurgio; W. Fernando; B. Salvachua; D. Lopez; R. Stanek; D. Underwood

    2011-09-30T23:59:59.000Z

    As a concern with the reliability and mass of current optical links in LHC experiments, we are investigating CW lasers and light modulators as an alternative to VCSELs. In addition we are developing data links in air, utilizing steering by MEMS mirrors and optical feedback paths for the control loop. Laser, modulator, and lens systems used are described, as well as two different electronic systems for a free space steering feedback loop. Our prototype system currently operates at 1.25 Gb/s, but could be upgraded. This link works over distances of order meters. Such links might enable one to move communication lasers (e.g. VCSELs) and optical fibers out of tracking detectors, for reasons such as reliability and power consumption. Some applications for free space data links, such as local triggering and data readout and trigger-clock distribution and links for much longer distances are also discussed.

  4. Carbon Cycling and Biosequestration Integrating Biology and Climate Through Systems Science Report from the March 2008 Workshop

    SciTech Connect (OSTI)

    Graber, J.; Amthor, J.; Dahlman, R.; Drell, D.; Weatherwax, S.

    2008-12-01T23:59:59.000Z

    One of the most daunting challenges facing science in the 21st Century is to predict how Earth's ecosystems will respond to global climate change. The global carbon cycle plays a central role in regulating atmospheric carbon dioxide (CO{sub 2}) levels and thus Earth's climate, but our basic understanding of the myriad of tightly interlinked biological processes that drive the global carbon cycle remains limited at best. Whether terrestrial and ocean ecosystems will capture, store, or release carbon is highly dependent on how changing climate conditions affect processes performed by the organisms that form Earth's biosphere. Advancing our knowledge of biological components of the global carbon cycle is thus crucial to predicting potential climate change impacts, assessing the viability of climate change adaptation and mitigation strategies, and informing relevant policy decisions. Global carbon cycling is dominated by the paired biological processes of photosynthesis and respiration. Photosynthetic plants and microbes of Earth's land-masses and oceans use solar energy to transform atmospheric CO{sub 2} into organic carbon. The majority of this organic carbon is rapidly consumed by plants or microbial decomposers for respiration and returned to the atmosphere as CO{sub 2}. Coupling between the two processes results in a near equilibrium between photosynthesis and respiration at the global scale, but some fraction of organic carbon also remains in stabilized forms such as biomass, soil, and deep ocean sediments. This process, known as carbon biosequestration, temporarily removes carbon from active cycling and has thus far absorbed a substantial fraction of anthropogenic carbon emissions.

  5. Links - 88-Inch Cyclotron

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > The EnergyCenter (LMI-EFRC) - CenterLinks Berkeley Lab Links: Nuclear

  6. Links - Cyclotron Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > The EnergyCenter (LMI-EFRC) - CenterLinks Berkeley Lab Links: Faculty

  7. Sector 30 - useful links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Useful Links Sector 30 Printing from your laptop at the beamline Data retrival onsite from ftp:ftp.xray.aps.anl.govpubsector30 Sector Orientation Form HERIX experiment header...

  8. Biological and Environmental Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisiting the TWP TWPAlumniComplexMaterialProductionBiological and

  9. Biology | More Science | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisiting the TWP TWPAlumniComplexMaterialProductionBiologicalLaboratories

  10. Preparing for Transfer Biological Engineering

    E-Print Network [OSTI]

    Walter, M.Todd

    Environmental Engineering Game Design Industrial Systems & Information Technology Information Science MaterialsPreparing for Transfer Majors: Biological Engineering Chemical Engineering Civil Engineering Computer Science Electrical & Computer Engineering Engineering Physics Environmental Engineering

  11. Development of a Model, Metal-reducing Microbial Community for a System Biology Level Assessment of Desulfovibrio vulgaris as part of a Community

    SciTech Connect (OSTI)

    Elias, Dwayne; Schadt, Christopher; Miller, Lance; Phelps, Tommy; Brown, S. D.; Arkin, Adam; Hazen, Terry; Drake, Megin; Yang, Z.K.; Podar, Mircea

    2010-05-17T23:59:59.000Z

    One of the largest experimental gaps is between the simplicity of pure cultures and the complexity of open environmental systems, particularly in metal-contaminated areas. These microbial communities form ecosystem foundations, drive biogeochemical processes, and are relevant for biotechnology and bioremediation. A model, metal-reducing microbial community was constructed as either syntrophic or competitive to study microbial cell to cell interactions, cell signaling and competition for resources. The microbial community was comprised of the metal-reducing Desulfovibrio vulgaris Hildenborough and Geobacter sulfurreducens PCA. Additionally, Methanococcus maripaludis S2 was added to study complete carbon reduction and maintain a low hydrogen partial pressure for syntrophism to occur. Further, considerable work has been published on D. vulgaris and the D. vulgaris/ Mc. maripaludis co-culture both with and without stress. We are extending this work by conducting the same stress conditions on the model community. Additionally, this comprehensive investigation includes physiological and metabolic analyses as well as specially designed mRNA microarrays with the genes for all three organisms on one slide so as to follow gene expression changes in the various cultivation conditions as well as being comparable to the co- and individual cultures. Further, state-of -the-art comprehensive AMT tag proteomics allows for these comparisons at the protein level for a systems biology assessment of a model, metal-reducing microbial community. Preliminary data revealed that lactate oxidation by D. vulgaris was sufficient to support both G. sulfurreducens and M. maripaludis via the excretion of H2 and acetate. Fumarate was utilized by G. sulfurreducens and reduced to succinate since neither of the other two organisms can reduce fumarate. Methane was quantified, suggesting acetate and H2 concentrations were sufficient for M. maripaludis. Steady state community cultivation will allow for a comprehensive, system biology level analysis of a metal-reducing microbial community.

  12. Bioinformatics & Computational Biology

    E-Print Network [OSTI]

    Richner, Heinz

    Bioinformatics & Computational Biology Master of Science in Bioinformatics and Computational Biology (90 ECTS) Contact Information Programme administration Bioinformatics and Computational Biology.unifr.ch/msc Programme administration Bioinformatics and Computational Biology University of Bern Baltzerstrasse 6 CH

  13. Nuclear Data Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible for Renewable Energy:Nanowire3627 Federal Register /7 This is aLinks to Useful Online

  14. ARM - Quick Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadap Documentation TDMADAP :ProductsVaisala CL51 ceilometergovPublicationsPublications4936Links

  15. ARM - Related Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadap Documentation TDMADAP :ProductsVaisala CL51Instruments Related Links RHUBC-IIActRecovery

  16. Links (pbl/contracts)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn12electron 9 5Let us countLighting Useful Links BIOSYNC:DOE

  17. Wind Power Link

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengtheningWildfires may contribute more to globalWind Power Links These other

  18. A Study to Determine the Biological Feasibility of a New Fish Tagging System : Annual Report 1990-1993.

    SciTech Connect (OSTI)

    Prentice, Earl F.; Maynard, D.J.; Downing, S.L. (and others)

    1994-01-01T23:59:59.000Z

    In 1983, the National Marine Fisheries Service (NMFS) began a multiyear cooperative research program with the Bonneville Power Administration (BPA) to evaluate a new miniaturized identification system that could be used with salmonids. The system is referred to as the passive-integrated-transponder (PIT) tagging and interrogation system. The program has focused on determining the effects of PIT tags on juvenile and adult salmonids, as well as the development and evaluation of tagging and interrogation methods. Earlier results of the program have been reported in annual reports and journal articles cited in this report. This report covers the work per formed from 1990 through 1993. For convenience, the report is divided into three sections: (1) Interrogation and separation systems at Columbia River Basin dams; (2) Systems development and evaluation; and (3) Information and technology transfer.

  19. Design and Test of DC Voltage Link Conversion System and Brushless Doubly-Fed Induction Generator for Variable-Speed Wind Energy Applications: August 1999--May 2003

    SciTech Connect (OSTI)

    Lipo, T.A.; Panda, D.; Zarko, D.

    2005-11-01T23:59:59.000Z

    This report describes four low-cost alternative power converters for processing the power developed by a doubly fed wound-rotor induction generator for wind energy conversion systems.

  20. Purdue AgronomyPurdue AgronomyCrop, Soil, and EnvironmEntal SCiEnCES Wastewater Biological Oxygen Demand in Septic Systems

    E-Print Network [OSTI]

    Holland, Jeffrey

    , commonly called a biomat. This biomat is where the bulk of biological wastewater treatment occursPurdue AgronomyPurdue AgronomyCrop, Soil, and EnvironmEntal SCiEnCES Wastewater Biological Oxygen to surface or groundwater it can result in low dissolved oxygen #12; Wastewater Biological Oxygen Demand

  1. Genomic and Systems Biology Analyses of Social Behavior or Evolutionary Genomic Analyses of Insect Society: Eat, Drink, and Be Scary (2011 JGI User Meeting)

    SciTech Connect (OSTI)

    Robinson, Gene

    2011-03-23T23:59:59.000Z

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Gene Robinson of the University of Illinois on "Genomic and Systems Biology Analyses of Social Behavior" at the 6th Annual Genomics of Energy & Environment Meeting on March 23, 2011

  2. The Encyclopedia of Systems Biology and OMICS (first presentation) and The ISA Infrastructure for Multi-omics Data (second presentation) (GSC8 Meeting)

    SciTech Connect (OSTI)

    Kolker, Eugene [Seattle Children's Hospital; Sansone, Susanna [EBI

    2011-09-11T23:59:59.000Z

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Eugene Kolker from Seattle Children's Hospital briefly discusses "The Encyclopedia of Systems Biology and OMICS," followed by Susanna Sansone from the EBI on "The ISA Infrastructure for multi-omics data" at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 11, 2009.

  3. Genomic and Systems Biology Analyses of Social Behavior or Evolutionary Genomic Analyses of Insect Society: Eat, Drink, and Be Scary (2011 JGI User Meeting)

    ScienceCinema (OSTI)

    Robinson, Gene

    2011-06-03T23:59:59.000Z

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Gene Robinson of the University of Illinois on "Genomic and Systems Biology Analyses of Social Behavior" at the 6th Annual Genomics of Energy & Environment Meeting on March 23, 2011

  4. The Encyclopedia of Systems Biology and OMICS (first presentation) and The ISA Infrastructure for Multi-omics Data (second presentation) (GSC8 Meeting)

    ScienceCinema (OSTI)

    Kolker, Eugene [Seattle Children's Hospital]; Sansone, Susanna [EBI

    2011-04-28T23:59:59.000Z

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Eugene Kolker from Seattle Children's Hospital briefly discusses "The Encyclopedia of Systems Biology and OMICS," followed by Susanna Sansone from the EBI on "The ISA Infrastructure for multi-omics data" at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 11, 2009.

  5. Standby Electric Generators for Emergency Farm Use Susan W. Gay, Extension Engineer, Biological Systems Engineering, Virginia Tech

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    -phase system. This publication only discusses single-phase motors. Electric motors for agricultural use require start. Gasoline-, liquid-propane- (LP-) gas-, and diesel-fueled models are available. Engine

  6. Biological Statistics and Computational Biology Seminar Series

    E-Print Network [OSTI]

    Keinan, Alon

    . Williams Professor of Biomedical Informations and Co-Director, Yale Computational Biology & Bioinformatics co-director of the Yale Computational Biology and Bioinformatics Program. In addition to the KeckBiological Statistics and Computational Biology Seminar Series Dr. Mark B. Gerstein Albert L

  7. LEED LINKS MENTOR TRAINING PROGRAM LEED LINKS Mentor Program

    E-Print Network [OSTI]

    Evans, Paul G.

    LEED LINKS MENTOR TRAINING PROGRAM LEED LINKS Mentor Program Provides ongoing support for new of LEED LINKS: LEED LINKS Community Building Academic Check-Ins Involvement Check-Ins Mentor-Mentee One-on-Ones A word from the LEED LINKS mentor "I thoroughly enjoyed my time as a mentor for LEED

  8. Loop Quantum Theory Applied to Biology and Nonlinear Whole Biology

    E-Print Network [OSTI]

    Yi-Fang Chang

    2008-01-02T23:59:59.000Z

    The loop quantum theory, which constitutes a very small discontinuous space, as new method is applied to biology. The model of protein folding and lungs is proposed. In the model, some known results are used, and four approximate conclusions are obtained: their structures are quantized, their space regions are finite, various singularities correspond to folding and crossed points, and different types of catastrophe exist. Further, based on the inseparability and correlativity of the biological systems, the nonlinear whole biology is proposed, and four basic hypotheses are formed. It may unify reductionism and holism, structuralism and functionalism. Finally, the medical meaning of the theory is discussed briefly.

  9. Resources & Links

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  10. Bisfuel links - Photosynthesis tag

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  11. Bisfuel links - Presentations

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  12. Bisfuel links - Seminars

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  13. The porous media model for the hydraulic system of a conifer tree: linking sap flux data to1 transpiration rate2

    E-Print Network [OSTI]

    Soatto, Stefano

    hydraulic system but also11 requires a direct estimation of its properties. Our proposed PM model play a dominant role in controlling CO2 uptake and4 partitioning of net radiation between latent-atmosphere flux measurement networks6 and free air CO2 enrichment (FACE) experiments require a quantitative

  14. The final publication is available at link.springer.com: 10.1007/s11367-013-0631-z Exploitation scenarios in industrial system LCA

    E-Print Network [OSTI]

    Boyer, Edmond

    -based LCA, exploitation scenario. 1. Introduction In recent decades, Life Cycle Assessment (LCA) has become-based LCA model ensures the reliability of results in situations where the system life cycle is very of Life Cycle Assessment 19, 1 (2014) pp 231-245" DOI : 10.1007/s11367-013-0631-z #12;2 cycle

  15. ULTRASONIC BIOLOGICAL EFFECT EXPOSURE SYSTEM W. D. O'Brien, Jr., C. L. Christman and S. Yarrow

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    which, in turn, is monitored by the minicomputer with an r.f. digital voltmeter. controlled, water to ultrasonic energy. The system can reproduce the ultrasonic signals of medical diagnostic and therapeutic. minicomputer controls the exposure time and the net electrical power to the ultrasonic transducer assembly

  16. Curriculum Vitae of Paulien Hogeweg Theoretical Biology and Bioinformatics Group, Utrecht University

    E-Print Network [OSTI]

    Utrecht, Universiteit

    Curriculum Vitae of Paulien Hogeweg Theoretical Biology and Bioinformatics Group, Utrecht.g. genomic data), the dynamic modeling approaches referred to as "systems biology", "computational life sciences", "computational biology", and which partially overlaps with "complex systems research

  17. Biologically Inspired Photocatalytically Active Membranes for Water Treatment

    E-Print Network [OSTI]

    Kinsinger, Nichola

    2013-01-01T23:59:59.000Z

    wastewater treatment systems include treatment of the influent by a series of stages: pretreatment, primary sedimentation, biological

  18. Helpful Links - Hanford Site

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  19. NREL: News - Related Links

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  20. Comments on: Links

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  1. News Links | Jefferson Lab

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  2. Link Alpha A

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  3. Link Alpha B

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  4. Link Alpha C

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  5. Link Alpha D

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  6. Link Alpha E

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  7. Link Alpha F

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  8. Link Alpha G

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  9. Link Alpha H

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  10. Link Alpha I

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  11. Link Alpha J

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  12. Link Alpha K

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  13. Link Alpha L

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  14. Link Alpha M

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  15. Link Alpha N

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  16. Link Alpha O

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  17. Link Alpha P

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  18. Link Alpha Q

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  19. Link Alpha R

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  20. Link Alpha S

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  1. Link Alpha T

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  2. Link Alpha V

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  3. Link Alpha W

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  4. Link Alpha Y

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  5. Link Alpha Z

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  6. Nuclear Data Links

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  7. Page 11, Links

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  8. CAMD Nanofabrication Links

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  9. CAMD Nanofabrication Links

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  10. WIPP - Related Links

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  11. A-Z Link

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  12. AlumniLink

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisiting the TWP TWPAlumni Alumni PARC/I-CARES CERTIFICATE IN RENEWABLE ENERGY

  13. Bisfuel links - EFRC

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  14. Bisfuel links - Professional organizations

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  15. Bisfuel links - Research centers

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  16. Bisfuel links - Video

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  17. astro_links.dvi

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  18. FINAL REPORT FOR: OPTIMIZATION OF BIOLOGICAL

    E-Print Network [OSTI]

    AND SUSPENDED GROWTH WASTEWATER TREATMENT SYSTEM DECEMBER, 1994 Prepared for: Environment Canada Environment#12;FINAL REPORT FOR: OPTIMIZATION OF BIOLOGICAL PHOSPHORUS AND AMMONIA REMOVAL IN A COMBINED FIXED;Optimization of Biological Phosphorus and Ammonia Removal in a Combined Fixed & Suspended Growth System i

  19. On Biology as an Emergent Science

    E-Print Network [OSTI]

    H. Pierre Noyes

    2007-05-31T23:59:59.000Z

    Biology is considered here as an "emergent science" in the sense of Anderson and of Laughlin and Pines. It is demonstrated that a straightforward mathematical definition of "biological system" is useful in showing how biology differs in structure from the lower levels in Anderson's "More is Different" hierarchy. Using cells in a chemostat as a paradigmatic exemplar of a biological system, it is found that a coherent collection of metabolic pathways through a single cell in the chemostat also satisfies the proposed definition of a biological system. This provides a theoretical and mathematical underpinning for Young's fundamental model of biological organization and integration. Evidence for the therapeutic efficacy of Young's method of analysis is provided by preliminary results of clinical trials of a specific application of Young's model to the treatment of cancer cachexia.

  20. Bioinformatics Computational Biology

    E-Print Network [OSTI]

    Mayfield, John

    Bioinformatics and Computational Biology Interdepartmental Graduate Program GRADUATE STUDENT HANDBOOK FALL 2006 Bioinformatics and Computational Biology Interdepartmental Graduate Program GRADUATE STUDENT HANDBOOK FALL 2006 #12;1 Welcome to the Bioinformatics and Computational Biology (BCB) program

  1. Multilevel DC link inverter

    DOE Patents [OSTI]

    Su, Gui-Jia

    2003-06-10T23:59:59.000Z

    A multilevel DC link inverter and method for improving torque response and current regulation in permanent magnet motors and switched reluctance motors having a low inductance includes a plurality of voltage controlled cells connected in series for applying a resulting dc voltage comprised of one or more incremental dc voltages. The cells are provided with switches for increasing the resulting applied dc voltage as speed and back EMF increase, while limiting the voltage that is applied to the commutation switches to perform PWM or dc voltage stepping functions, so as to limit current ripple in the stator windings below an acceptable level, typically 5%. Several embodiments are disclosed including inverters using IGBT's, inverters using thyristors. All of the inverters are operable in both motoring and regenerating modes.

  2. Facilitation Guide Forging the Link

    E-Print Network [OSTI]

    Facilitation Guide Forging the Link: Linking the Economic Incentives of Low Impact Development of the economic incentives as well as how LID plays a role in helping communities adapt to changes in climate. Now heard? What about inconsistent? #12;Forging the Link: Linking the Economic Benefits of Low Impact

  3. Statistical methods to infer biological interactions

    E-Print Network [OSTI]

    Tucker, George Jay

    2014-01-01T23:59:59.000Z

    Biological systems are extremely complex, and our ability to experimentally measure interactions in these systems is limited by inherent noise. Technological advances have allowed us to collect unprecedented amounts of raw ...

  4. Biological Statistics and Computational Biology Seminar Series

    E-Print Network [OSTI]

    Keinan, Alon

    Science and the Center for Computational Biology and Bioinformatics at Columbia University. Dr. PeBiological Statistics and Computational Biology Seminar Series Dr. Itsik Pe'er Associate Professor of Computer Science Columbia University Itsik Pe'er is an associate professor in the Department of Computer

  5. Microfluidics for quantitative biology

    E-Print Network [OSTI]

    Adler, Micha

    2012-01-01T23:59:59.000Z

    CALIFORNIA, SAN DIEGO Microfluidics for Quantitative BiologyChapter 1: Microfluidics.………………………………………………………..… 1 1.1OF THE DISSERTATION Microfluidics for Quantitative Biology

  6. Plant Vascular Biology 2010

    SciTech Connect (OSTI)

    Ding, Biao

    2014-11-17T23:59:59.000Z

    This grant supported the Second International Conference on Plant Vascular Biology (PVB 2010) held July 24-28, 2010 on the campus of Ohio State University, Columbus, Ohio. Biao Ding (Ohio State University; OSU) and David Hannapel (Iowa State University; ISU) served as co-chairs of this conference. Biao Ding served as the local organizer. PVB is defined broadly here to include studies on the biogenesis, structure and function of transport systems in plants, under conditions of normal plant growth and development as well as of plant interactions with pathogens. The transport systems cover broadly the xylem, phloem, plasmodesmata and vascular cell membranes. The PVB concept has emerged in recent years to emphasize the integrative nature of the transport systems and approaches to investigate them.

  7. PIPELINES AS COMMUNICATION NETWORK LINKS

    SciTech Connect (OSTI)

    Kelvin T. Erickson; Ann Miller; E. Keith Stanek; C.H. Wu; Shari Dunn-Norman

    2005-03-14T23:59:59.000Z

    This report presents the results of an investigation into two methods of using the natural gas pipeline as a communication medium. The work addressed the need to develop secure system monitoring and control techniques between the field and control centers and to robotic devices in the pipeline. In the first method, the pipeline was treated as a microwave waveguide. In the second method, the pipe was treated as a leaky feeder or a multi-ground neutral and the signal was directly injected onto the metal pipe. These methods were tested on existing pipeline loops at UMR and Batelle. The results reported in this report indicate the feasibility of both methods. In addition, a few suitable communication link protocols for this network were analyzed.

  8. Agency Links Agency Links and Proposal Development Resources

    E-Print Network [OSTI]

    Mather, Patrick T.

    Agency Links - 1 - Agency Links and Proposal Development Resources National Institutes of Health NIH Peer Review: Grants & Cooperative Agreements (2013) Resources for applicants Parent Application Development Checklist from OSP Search for NSF grant recipients Writing aids / Resources Proposal Development

  9. Thermodynamics and Relativity: Possible Consequences of their Close Link

    E-Print Network [OSTI]

    Jean-Louis Tane

    2008-05-25T23:59:59.000Z

    The first part of this paper is a summary of a hypothesis previously advanced, suggesting the existence of a close link between thermodynamics and relativity. The second part is a preliminary comment about some possible consequences in the fields of physics, astronomy and biology.

  10. Electrostatic thin film chemical and biological sensor

    DOE Patents [OSTI]

    Prelas, Mark A. (Columbia, MO); Ghosh, Tushar K. (Columbia, MO); Tompson, Jr., Robert V. (Columbia, MO); Viswanath, Dabir (Columbia, MO); Loyalka, Sudarshan K. (Columbia, MO)

    2010-01-19T23:59:59.000Z

    A chemical and biological agent sensor includes an electrostatic thin film supported by a substrate. The film includes an electrostatic charged surface to attract predetermined biological and chemical agents of interest. A charge collector associated with said electrostatic thin film collects charge associated with surface defects in the electrostatic film induced by the predetermined biological and chemical agents of interest. A preferred sensing system includes a charge based deep level transient spectroscopy system to read out charges from the film and match responses to data sets regarding the agents of interest. A method for sensing biological and chemical agents includes providing a thin sensing film having a predetermined electrostatic charge. The film is exposed to an environment suspected of containing the biological and chemical agents. Quantum surface effects on the film are measured. Biological and/or chemical agents can be detected, identified and quantified based on the measured quantum surface effects.

  11. Functional quantum biology in photosynthesis and magnetoreception

    E-Print Network [OSTI]

    Lambert, Neill; Cheng, Yuan-Chung; Li, Che-Ming; Chen, Guang-Yin; Nori, Franco

    2012-01-01T23:59:59.000Z

    Is there a functional role for quantum mechanics or coherent quantum effects in biological processes? While this question is as old as quantum theory, only recently have measurements on biological systems on ultra-fast time-scales shed light on a possible answer. In this review we give an overview of the two main candidates for biological systems which may harness such functional quantum effects: photosynthesis and magnetoreception. We discuss some of the latest evidence both for and against room temperature quantum coherence, and consider whether there is truly a functional role for coherence in these biological mechanisms. Finally, we give a brief overview of some more speculative examples of functional quantum biology including the sense of smell, long-range quantum tunneling in proteins, biological photoreceptors, and the flow of ions across a cell membrane.

  12. Functional quantum biology in photosynthesis and magnetoreception

    E-Print Network [OSTI]

    Neill Lambert; Yueh-Nan Chen; Yuan-Chung Cheng; Che-Ming Li; Guang-Yin Chen; Franco Nori

    2012-05-04T23:59:59.000Z

    Is there a functional role for quantum mechanics or coherent quantum effects in biological processes? While this question is as old as quantum theory, only recently have measurements on biological systems on ultra-fast time-scales shed light on a possible answer. In this review we give an overview of the two main candidates for biological systems which may harness such functional quantum effects: photosynthesis and magnetoreception. We discuss some of the latest evidence both for and against room temperature quantum coherence, and consider whether there is truly a functional role for coherence in these biological mechanisms. Finally, we give a brief overview of some more speculative examples of functional quantum biology including the sense of smell, long-range quantum tunneling in proteins, biological photoreceptors, and the flow of ions across a cell membrane.

  13. E-Print Network 3.0 - applications molecular biology Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    applications molecular biology Page: << < 1 2 3 4 5 > >> 1 COMMITTEE ON GENETICS, GENOMICS & SYSTEMS BIOLOGY: SUGGESTED STUDENT TRACKS AUTUMN QUARTER WINTER QUARTER SPRING...

  14. Artificial Homeostasis: Integrating Biologically Inspired Computing

    E-Print Network [OSTI]

    Kent, University of

    - mune systems and a novel artificial endocrine system. The natural counterparts of these three of these artificial systems to yield artificially homeostatic systems. The components develop in a common envi. Thus we propose to consider the artificial counterparts of these three biological systems. The use

  15. The living commons : a spatial theory for biological design

    E-Print Network [OSTI]

    Telhan, Orkan

    2013-01-01T23:59:59.000Z

    Biological design is as ancient as human civilization. For thousands of years, living systems and natural processes have been manipulated by humans and their biological outcomes have been customized for different purposes. ...

  16. Chemistry meets biology in colitis-associated carcinogenesis

    E-Print Network [OSTI]

    Mangerich, Aswin

    The intestine comprises an exceptional venue for a dynamic and complex interplay of numerous chemical and biological processes. Here, multiple chemical and biological systems, including the intestinal tissue itself, its ...

  17. Boston University Physics Colloquium Microscale propulsion in biological and

    E-Print Network [OSTI]

    Mohanty, Raj

    Boston University Physics Colloquium Microscale propulsion in biological and engineered systems biological locomotion and engineered propulsion. In the first example, we examine swimming microorganisms the microstructure. In the second example, we examine engineered magnetic artificial microswimmers which can

  18. Systems biology approach to bioremediation

    E-Print Network [OSTI]

    Chakraborty, R.

    2013-01-01T23:59:59.000Z

    DR: Potential for bioremediation of uranium-contaminatedsoil before and after bioremediation. Arch Environ ContamWT: Comparative bioremediation of soils contaminated with

  19. Artificial ciliary bundles with nano fiber tip links

    E-Print Network [OSTI]

    Asadnia, Mohsen; Miao, Jianmin; Triantafyllou, Michael

    2015-01-01T23:59:59.000Z

    Mechanosensory ciliary bundles in fishes are the inspiration for carefully engineered artificial flow sensors. We report the development of a new class of ultrasensitive MEMS flow sensors that mimic the intricate morphology of the ciliary bundles, including the stereocilia, tip links, and the cupula, and thereby achieve threshold detection limits that match the biological example. An artificial ciliary bundle is achieved by fabricating closely-spaced arrays of polymer micro-pillars with gradiating heights. Tip links that form the fundamental sensing elements are realized through electrospinning aligned PVDF piezoelectric nano-fibers that link the distal tips of the polymer cilia. An optimized synthesis of hyaluronic acid-methacrylic anhydride hydrogel that results in properties close to the biological cupula, together with drop-casting method are used to form the artificial cupula that encapsulates the ciliary bundle. In testing, fluid drag force causes the ciliary bundle to slide, stretching the flexible nan...

  20. Balanced link for dry coal extrusion pumps

    DOE Patents [OSTI]

    Bebejian, Maral

    2013-10-22T23:59:59.000Z

    A link which defines a link body that includes a multiple of link plates integral with a link body, the link body disposed at least partially forward of a forward edge of the multiple of link plates.

  1. The Link Collections A Register of Papers of Edwin A. Link, Marion Clayton Link, The

    E-Print Network [OSTI]

    Suzuki, Masatsugu

    Description of Series Correspondence (19391981) Enclosures (19411979) Advertising Brochures and Company Charts, Diagrams, and Maps Financial Records Legal Documents Legislation Logs and Journals. Link Advertising Brochures and Company Publications E.A. Link Announcements, Business Cards

  2. Informatics Strategies for Large-Scale Novel Cross-linking Analysis

    SciTech Connect (OSTI)

    Anderson, Gordon A.; Tolic, Nikola; Tang, Xiaoting; Zheng, Chunxiang; Bruce, James E.

    2007-08-03T23:59:59.000Z

    The analysis of protein interactions in biological systems represents a significant challenge for today's technology. Chemical cross-linking provides the potential to impart new chemical bonds in a complex system that result in mass changes in the analysis of a set of tryptic peptides. However, system complexity and cross-linking product heterogeneity have precluded widespread chemical cross-linking use for large-scale identification of protein-protein interactions.The development of mass spectrometry identifiable cross-linkers called Protein Interaction Reporters (PIRs) has enabled on-cell chemical cross-linking experiments with product type differentiation. However, the complex datasets resultant from PIR experiments demand new informatics capabilities to allow interpretation. This manuscript details our efforts to develop such capabilities and describes the program X-links which allows PIR product type differentiation. Furthermore, we also present the results from Monte Carlo simulation of PIRtype experiments to provide false positive identification rate estimates for the PIR product type identification through observed precursor and released peptide masses. Our simulations also provide peptide identification calculations based on accurate masses and database complexity that can provide an estimation of false positive rates for peptide identification. Overall, the calculations show a low rate of false positive identification of PIR product types due to random mass matching of approximately 12% with 10 ppm mass measurement accuracy. In addition, consideration of a reduced database resulting from stage 1 analysis of Shewanella oneidensis MR-1 containing 367 proteins resulted in a significant reduction of expected identification false positive identification rate estimation compared to that from the entire Shewanella oneidensis MR-1 proteome.

  3. Informatics Strategies for Large-Scale Novel Cross-linking Analysis

    SciTech Connect (OSTI)

    Anderson, Gordon A.; Tolic, Nikola; Tang, Xiaoting; Zheng, Chunxiang; Bruce, James E.

    2007-09-01T23:59:59.000Z

    The analysis of protein interactions in biological systems represents a significant challenge for today's technology. Chemical cross-linking provides the potential to impart new chemical bonds in a complex system that result in mass changes in the analysis of a set of tryptic peptides. However, system complexity and cross-linking product heterogeneity have precluded widespread chemical cross-linking use for large-scale identification of protein-protein interactions. The development of mass spectrometry identifiable cross-linkers called Protein Interaction Reporters (PIRs) has enabled on-cell chemical cross-linking experiments with product type differentiation. However, the complex datasets resultant from PIR experiments demand new informatics capabilities to allow interpretation. This manuscript details our efforts to develop such capabilities and describes the program X-links which allows PIR product type differentiation. Furthermore, we also present the results from Monte Carlo simulation of PIRtype experiments to provide false positive identification rate estimates for the PIR product type identification through observed precursor and released peptide masses. Our simulations also provide peptide identification calculations based on accurate masses and database complexity that can provide an estimation of false positive rates for peptide identification. Overall, the calculations show a low rate of false positive identification of PIR product types due to random mass matching of approximately 12% with 10 ppm mass measurement accuracy. In addition, consideration of a reduced database resulting from stage 1 analysis of Shewanella oneidensis MR-1 containing 367 proteins resulted in a significant reduction of expected identification false positive identification rate estimation compared to that from the entire Shewanella oneidensis MR-1 proteome.

  4. Natural arsenic contamination of Holocene alluvial aquifers by linked tectonic, weathering, and microbial processes

    E-Print Network [OSTI]

    Fayek, Mostafa

    Natural arsenic contamination of Holocene alluvial aquifers by linked tectonic, weathering tectonic, geochemical, and biologic processes lead to natural arsenic contamination of groundwater-bearing minerals occurs. We propose a ``GBH-As'' model that ties together all of the important tectonic, biologic

  5. Biological Safety | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureCommentsEnergyandapproximately 10 wt%inand FuelBiological

  6. Computational Biology | More Science | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration would like submit theInnovationComputational Biology SHARE Computational

  7. Green Biologics | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetec AG Contracting JumpGoveNebraska:Ethanol LLC GO EthanolBiologics Jump to:

  8. Biological Applications of Synchrotron Radiation:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisiting the TWP TWPAlumniComplexMaterialProduction PetraBiological

  9. Partners and related links | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    are the organizations with which EMSL maintains closest relationships in high performance computing and software development. Partners Note: The links below leave this site...

  10. FormLink/FeynCalcFormLink : Embedding FORM in Mathematica and FeynCalc

    E-Print Network [OSTI]

    Feng Feng; Rolf Mertig

    2012-12-17T23:59:59.000Z

    FORM, a symbolic manipulation system, has been widely used in a lot of calculations for High Energy Physics due to its high performance and fficient design. Mathematica, another computational software program, has also widely been used, but more for reasons of generality and user-friendliness than for speed. Especially calculations involving tensors and noncommutative operations like calculating Dirac traces can be rather slow in Mathematica, compared to FORM. In this article we describe FormLink and FeynCalcFormLink, two Mathematica packages to link Mathematica and FeynCalc with FORM. FormLink can be used without FeynCalc and FeynCalcFormLink, which is an extension loading FormLink and FeynCalc automatically. With these two packages the impressive speed and other special features of FORM get embedded into the generality of Mathematica and FeynCalc in a simple manner. FeynCalcFormLink provides a FORM-based turbo for FeynCalc, making it much more efficient. FormLink turns Mathematica into an editor and code organizer for FORM.

  11. Process Manual Biological & Agricultural

    E-Print Network [OSTI]

    Boas, Harold P.

    · · · · ·t t ·t ·t t t ·t . ~ t · · Process· Manual Biological & Agricultural Engineering MANUAL FOR THE BIOLOGICAL AND AGRICULTURAL ENGINEERING DEPARTMENT TexasA&MUniversity Article I. NAME The name ofthis organization shall be the Biological and Agricultural Engineering Department (abbreviated

  12. The Climate Impacts LINK Project

    E-Print Network [OSTI]

    Feigon, Brooke

    The Climate Impacts LINK Project The Climatic Research Unit, University of East Anglia Funded by the UK Department of the Environment, Transport and the Regions, Contract Ref EPG 1/1/68 The Climate Impacts LINK Project: Applying Results from the Hadley Centre's Climate Change Experiments for Climate

  13. Superfluid 4 He weak links

    E-Print Network [OSTI]

    Packard, Richard E.

    from the response of the cell to a step in the chemical potential difference across the array. When present a "Chemical potential battery" for superfluid 4He weak link cells, whereby a constant heater power in this dissertation represent a breakthrough in super- fluid 4He weak link research, and provide a big step

  14. Applications of microfluidics in chemical biology Douglas B Weibel1

    E-Print Network [OSTI]

    Prentiss, Mara

    Applications of microfluidics in chemical biology Douglas B Weibel1 and George M Whitesides2 This review discusses the application of microfluidics in chemical biology. It aims to introduce the reader to microfluidics, describe characteristics of microfluidic systems that are useful in studying chemical biology

  15. Links

    Broader source: Energy.gov [DOE]

    More Legal Research ResourcesEnergy Law NetLegal Citation Style GuideNuclear Regulatory LegislationOpen CRSPublic Library of LawTreatiesU.S. Code Classification TablesU.S. Congressional Documents...

  16. Gravitational and Space Biology 18(2) June 2005 11 WORMS IN SPACE? A MODEL BIOLOGICAL DOSIMETER

    E-Print Network [OSTI]

    Baillie, David

    is available about the biological consequences of solar flares. Biological systems are not simply passive potential for the design of a biological dosimeter. In this paper, we describe the advantages of this model about up-coming meetings, abstracts, in- house publications, researchers' contact information

  17. Election in complete asynchronous networks with intermittent link failures 

    E-Print Network [OSTI]

    Lokre, Jahnavi V.

    1991-01-01T23:59:59.000Z

    . Initially, no node knows the identifier of any other node. Each node u knows the number of nodes n in the distributed system, the maximum number f of faulty links incident on u, and that the network is complete. A distributed algorithm on a network is a.... The algorithm uses O(n + nf ) messages. We assume that there are at most f faulty links incident on each node, where f & [ "s J. Let I be a link between nodes u and v. By the definition of link failure, link I is considered faulty if I loses at least one...

  18. North Pacific Gyre Oscillation links ocean climate and ecosystem E. Di Lorenzo,1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    North Pacific Gyre Oscillation links ocean climate and ecosystem change E. Di Lorenzo,1 N Pacific Gyre Oscillation links ocean climate and ecosystem change, Geophys. Res. Lett., 35, L08607, doi:10 to explain physical and biological fluctuations in the Northeast Pacific Ocean [Lynn et al., 1998; Lavaniegos

  19. Links - MST - UW Plasma Physics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > The EnergyCenter (LMI-EFRC) - CenterLinks Berkeley Lab Links:

  20. links | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengtheningWildfires mayYuan T.External Links External Links This page

  1. ECOLOGY ABIO 320 FALL 2013 DR. CARACO BIOLOGY 253

    E-Print Network [OSTI]

    Caraco, Thomas

    1 ECOLOGY ABIO 320 FALL 2013 DR. CARACO BIOLOGY 253 Course Web Page: www Scores Links to Lectures #12;2 Texts Gotelli, NJ. A Primer of Ecology. 4 th Edit., 2008 (Required ) Alstad, D. Basic Populus Models of Ecology. 2001 [Rec ] Link to Download Populus on Course Web Page

  2. March 2014 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    March 2014 Most Viewed Documents for Biology And Medicine Science Subject Feed Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A....

  3. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production

    SciTech Connect (OSTI)

    James, B. D.; Baum, G. N.; Perez, J.; Baum, K. N.

    2009-09-01T23:59:59.000Z

    Report documenting the biological and engineering characteristics of five algal and bacterial hydrogen production systems selected by DOE and NREL for evaluation.

  4. A New Approach to the Link Budget Concept for an OAM Communication Link

    E-Print Network [OSTI]

    Cagliero, Andrea; Gaffoglio, Rossella; Sacco, Bruno

    2015-01-01T23:59:59.000Z

    Following on from the increasing interest for electromagnetic waves carrying Orbital Angular Momentum (OAM), different configurations of antenna systems able to generate such beams have been proposed. However, in our opinion, a traditional radiation pattern approach does not provide the right picture of an OAM-based communication link. For this reason we propose a new general concept, the "OAM-link pattern", which takes into account the peculiar phase structure characterizing these waves. Focusing on OAM transmissions between antenna arrays, we introduce a formula for the link budget evaluation which describes the whole communication link and directly leads to a "classically shaped" main lobe pattern for a proper rephased reception in the case of uniform circular arrays.

  5. Linked Deposit Loan Program (Kentucky)

    Broader source: Energy.gov [DOE]

    The Linked Deposit Program provides loan financing for small businesses of up to $100,000 for up to 7 years. The State Investment Commission invests funds from the state's Abandoned Property Cash...

  6. Biology and Soft Matter | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials Find Find More LikeAndreasHelp(SC) BiologicalBiology

  7. Biological tracer method

    DOE Patents [OSTI]

    Strong-Gunderson, J.M.; Palumbo, A.V.

    1998-09-15T23:59:59.000Z

    The present invention is a biological tracer method for characterizing the movement of a material through a medium, comprising the steps of: introducing a biological tracer comprising a microorganism having ice nucleating activity into a medium; collecting at least one sample of the medium from a point removed from the introduction point; and analyzing the sample for the presence of the biological tracer. The present invention is also a method for using a biological tracer as a label for material identification by introducing a biological tracer having ice nucleating activity into a material, collecting a sample of a portion of the labelled material and analyzing the sample for the presence of the biological tracer. 2 figs.

  8. Biological tracer method

    DOE Patents [OSTI]

    Strong-Gunderson, Janet M. (Ten Mile, TN); Palumbo, Anthony V. (Oak Ridge, TN)

    1998-01-01T23:59:59.000Z

    The present invention is a biological tracer method for characterizing the movement of a material through a medium, comprising the steps of: introducing a biological tracer comprising a microorganism having ice nucleating activity into a medium; collecting at least one sample of the medium from a point removed from the introduction point; and analyzing the sample for the presence of the biological tracer. The present invention is also a method for using a biological tracer as a label for material identification by introducing a biological tracer having ice nucleating activity into a material, collecting a sample of a portion of the labelled material and analyzing the sample for the presence of the biological tracer.

  9. Biological detector and method

    DOE Patents [OSTI]

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

    2014-04-15T23:59:59.000Z

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  10. Micro/nanofabricated environments for synthetic biology

    SciTech Connect (OSTI)

    Collier, Pat [ORNL; Simpson, Michael L [ORNL

    2011-01-01T23:59:59.000Z

    A better understanding of how confinement, crowding and reduced dimensionality modulate reactivity and reaction dynamics will aid in the rational and systematic discovery of functionality in complex biological systems. Artificial micro- and nanofabricated structures have helped elucidate the effects of nanoscale spatial confinement and segregation on biological behavior, particularly when integrated with microfluidics, through precise control in both space and time of diffusible signals and binding interactions. Examples of nanostructured interfaces for synthetic biology include the development of cell-like compartments for encapsulating biochemical reactions, nanostructured environments for fundamental studies of diffusion, molecular transport and biochemical reaction kinetics, and regulation of biomolecular interactions as functions of micro- and nanofabricated topological constraints.

  11. Agents in Bioinformatics, Computational and Systems Emanuela Merellia

    E-Print Network [OSTI]

    Luck, Michael

    Agents in Bioinformatics, Computational and Systems Biology Emanuela Merellia , Giuliano Armanob and management in bioinformatics and for systems modelling and simulation in computational and systems biology, Biological Systems Modelling and Simulation, Grid Computing, Semantic Web, Web Services, LIMS, Bioinformatics

  12. Cross-linked structure of network evolution

    SciTech Connect (OSTI)

    Bassett, Danielle S., E-mail: dsb@seas.upenn.edu [Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Department of Physics, University of California, Santa Barbara, California 93106 (United States); Sage Center for the Study of the Mind, University of California, Santa Barbara, California 93106 (United States); Wymbs, Nicholas F.; Grafton, Scott T. [Department of Psychology and UCSB Brain Imaging Center, University of California, Santa Barbara, California 93106 (United States)] [Department of Psychology and UCSB Brain Imaging Center, University of California, Santa Barbara, California 93106 (United States); Porter, Mason A. [Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, University of Oxford, Oxford OX2 6GG (United Kingdom) [Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, University of Oxford, Oxford OX2 6GG (United Kingdom); CABDyN Complexity Centre, University of Oxford, Oxford, OX1 1HP (United Kingdom); Mucha, Peter J. [Carolina Center for Interdisciplinary Applied Mathematics, Department of Mathematics, University of North Carolina, Chapel Hill, North Carolina 27599 (United States) [Carolina Center for Interdisciplinary Applied Mathematics, Department of Mathematics, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Department of Applied Physical Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)

    2014-03-15T23:59:59.000Z

    We study the temporal co-variation of network co-evolution via the cross-link structure of networks, for which we take advantage of the formalism of hypergraphs to map cross-link structures back to network nodes. We investigate two sets of temporal network data in detail. In a network of coupled nonlinear oscillators, hyperedges that consist of network edges with temporally co-varying weights uncover the driving co-evolution patterns of edge weight dynamics both within and between oscillator communities. In the human brain, networks that represent temporal changes in brain activity during learning exhibit early co-evolution that then settles down with practice. Subsequent decreases in hyperedge size are consistent with emergence of an autonomous subgraph whose dynamics no longer depends on other parts of the network. Our results on real and synthetic networks give a poignant demonstration of the ability of cross-link structure to uncover unexpected co-evolution attributes in both real and synthetic dynamical systems. This, in turn, illustrates the utility of analyzing cross-links for investigating the structure of temporal networks.

  13. Roadmap: Environmental and Conservation Biology Conservation Biology Bachelor of Science

    E-Print Network [OSTI]

    Sheridan, Scott

    Roadmap: Environmental and Conservation Biology ­Conservation Biology Bachelor of Science [AS or upper division) 4 #12;Roadmap: Environmental and Conservation Biology ­Conservation Biology Bachelor Summary on page 2 Conservation Biology Concentration Elective 2 See note 3 on page 2 Semester Five: [15

  14. Molecular Mechanism of Biological Proton Transport

    SciTech Connect (OSTI)

    Pomes, R.

    1998-09-01T23:59:59.000Z

    Proton transport across lipid membranes is a fundamental aspect of biological energy transduction (metabolism). This function is mediated by a Grotthuss mechanism involving proton hopping along hydrogen-bonded networks embedded in membrane-spanning proteins. Using molecular simulations, the authors have explored the structural, dynamic, and thermodynamic properties giving rise to long-range proton translocation in hydrogen-bonded networks involving water molecules, or water wires, which are emerging as ubiquitous H{sup +}-transport devices in biological systems.

  15. Performance Limits of Outdoor Wireless Optical Communication Links through Scattering and Turbulent Channels

    E-Print Network [OSTI]

    He, Qunfeng

    2012-01-01T23:59:59.000Z

    systems for unattended ground sensor networks. Proc. SPIE,link for unattended ground sensors. Proc. SPIE, [60] G. A.

  16. LTS Related Links - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn12electron 9 5 - -/e),,s - 16,3/14 LOWRelated Links About Us

  17. SexTant: Visualizing Time-Evolving Linked Geospatial Data

    E-Print Network [OSTI]

    Koubarakis, Manolis

    SexTant: Visualizing Time-Evolving Linked Geospatial Data Konstantina Bereta1 , Charalampos SexTant, a Web-based system for the visualiza- tion and exploration of time-evolving linked geospatial geospatial data has recently received attention as researchers and prac- titioners have started tapping

  18. Human Embryology & Developmental Biology

    E-Print Network [OSTI]

    Levi, Ran

    Biology is the modern synthesis of biological and medical sciences that looks at how the tissues, and is at the forefront of recent advances in modern medicine. Current research has shown that many of the molecular Web Pages for names). The Head of School of Medical Sciences is always available for advice regarding

  19. Molecular Biology DEGREE PROGRAMME

    E-Print Network [OSTI]

    Levi, Ran

    to the course co-ordinator for that module (See University Catalogue of Courses or SMS World Wide Web Pages in molecular biology have a wide range of career options, including virtually all areas of biology, medicine with mastering statistics, graphics and word processing software packages. General Enquiries The Degree Programme

  20. Mesangial cell biology

    SciTech Connect (OSTI)

    Abboud, Hanna E., E-mail: Abboud@uthscsa.edu

    2012-05-15T23:59:59.000Z

    Mesangial cells originate from the metanephric mesenchyme and maintain structural integrity of the glomerular microvascular bed and mesangial matrix homeostasis. In response to metabolic, immunologic or hemodynamic injury, these cells undergo apoptosis or acquire an activated phenotype and undergo hypertrophy, proliferation with excessive production of matrix proteins, growth factors, chemokines and cytokines. These soluble factors exert autocrine and paracrine effects on the cells or on other glomerular cells, respectively. MCs are primary targets of immune-mediated glomerular diseases such as IGA nephropathy or metabolic diseases such as diabetes. MCs may also respond to injury that primarily involves podocytes and endothelial cells or to structural and genetic abnormalities of the glomerular basement membrane. Signal transduction and oxidant stress pathways are activated in MCs and likely represent integrated input from multiple mediators. Such responses are convenient targets for therapeutic intervention. Studies in cultured MCs should be supplemented with in vivo studies as well as examination of freshly isolated cells from normal and diseases glomeruli. In addition to ex vivo morphologic studies in kidney cortex, cells should be studied in their natural environment, isolated glomeruli or even tissue slices. Identification of a specific marker of MCs should help genetic manipulation as well as selective therapeutic targeting of these cells. Identification of biological responses of MCs that are not mediated by the renin–angiotensin system should help development of novel and effective therapeutic strategies to treat diseases characterized by MC pathology.

  1. Biological Macromolecular Structures Data from the RCSB Protein Data Bank (RCSB PDB)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The Research Collaboratory for Structural Bioinformatics (RCSB) is a non-profit consortium that works to improve understanding of the function of biological systems through the study of the 3-D structure of biological macromolecules. The RCSB PDB is one of three sites serving as deposition, data processing, and distribution sites of the Protein Data Bank Archive. Each site provides its own view of the primary data, thus providing a variety of tools and resources for the global community. RCSB is also the official keeper for the PDB archive, with sole access authority to the PDB archive directory structure and contents. The RCSB PDB Information Portal for Biological Macromolecular Structures offers online tools for search and retrieval, for visualizing structures, for depositing, validating, or downloading data, news and highlights, a discussion forum, and links to other areas of related research. The PDB archive is a repository of atomic coordinates and other information describing proteins and other important biological macromolecules. Structural biologists use methods such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy to determine the location of each atom relative to each other in the molecule. They then deposit this information, which is then annotated and publicly released into the archive by the wwPDB. Results can be viewed as 3-D images or models.

  2. Master track Theoretical Biology & Bioinformatics

    E-Print Network [OSTI]

    Utrecht, Universiteit

    their master. Our two MSc courses "Computational Biology" and "Bioinformatics and Evolutionary GenomicsMaster track Theoretical Biology & Bioinformatics Modeling and bioinformatics is an important Biology & Bioinformatics provides courses introducing you to the basic concepts of modeling

  3. Phenomenological models in biological physics : cell growth and pluripotency maintenance

    E-Print Network [OSTI]

    Youk, Hyun

    2010-01-01T23:59:59.000Z

    A persistent challenge in quantitatively modeling a biological system is that the system often involves many components and just as dizzying number of interactions among those components. To further complicate matters, the ...

  4. Breaking information-thermodynamics link

    E-Print Network [OSTI]

    Robert Alicki

    2014-06-23T23:59:59.000Z

    The information-thermodynamics link is revisited, going back to the analysis of Szilard's engine. It is argued that instead of equivalence rather complementarity of physical entropy and information theoretical one is a correct concept. Famous Landauer's formula for a minimal cost of information processing is replaced by a new one which takes into account accuracy and stability of information encoding. Two recent experiments illustrating the information-energy conversion are critically discussed.

  5. Harvesting Residuals-Economic Energy Link

    E-Print Network [OSTI]

    Owens, E. T.; Curtis, D. B.

    HARVESTING RESIDUALS-ECONOMIC ENERGY LINK E.T. Owens, R.P.F. Research and Productivity Council, Fredericton, N.B. D.B. Curtis, P.Eng. Dept. Forests, Mines and ABSTRACT A description of systems used in integrated harvesting of quality...-for-energy. economics INTRODUCTION The conventional wisdom in efficient harvesting Was to leave the non-merchantable and marginal trees because they had no economic value in the market place. Current technology and a change in the relative values of energy from...

  6. The Fenno-Skan HVDC link commissioning

    SciTech Connect (OSTI)

    Nyman, A. (Swedish State Power Board, Vaellingby (Sweden)); Jaeaeskelaeinen, K.; Vaitomaa, M. (Imatran Voima OY, Vantaa (Finland)); Jansson, B.; Danielsson, K.G. (ABB Power Systems, Ludvika (Sweden))

    1994-01-01T23:59:59.000Z

    The commissioning of the Fenno-Skan HVDC link between Finland and Sweden, with the longest submarine dc cable in the world, is described. The main pre-commissioning activities, important for an efficient commissioning, are discussed together with time schedules and suitable organization forms. The procedures to test special control features, such as subsynchronous oscillation (SSO) damping control are presented. The full scale network interaction tests which are an important part of the commissioning are also discussed. These tests succeeded very well and provided a lot of information about the system behavior for future operation and planning purposes.

  7. Related Links | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA groupTuba City,Enriched UraniumPhysical Security Systems(PA)About| |About Us /

  8. Related Links | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

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  9. Viewing biology in action | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    biology in action Released: June 11, 2014 DOE-funded pilot program will create mesoscale biological imaging platform James Evans EMSL received first-year funding of almost...

  10. Todd Newberry: Professor of Biology

    E-Print Network [OSTI]

    Newberry, Andrew Todd; Jarrell, Randall; Regional History Project, UCSC Library

    2006-01-01T23:59:59.000Z

    Professor of Biology: Early Retirement page 44 Jarrell: ToProfessor of Biology: Early Retirement page 45 Jarrell: ToWar 33 Voluntary Early Retirement Incentive Program (VERIP)

  11. MAJOR CONFORMED CONTRACTS LINKS Site/Project Contract Link Idaho

    Office of Environmental Management (EM)

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  12. Work with Biological Materials

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Work with Biological Materials Print Planning A complete Experiment Safety Sheet (ESS) is required before work can be done at the ALS. This ESS is either a part of the proposal...

  13. Boston University College of Engineering Division of Systems Engineering

    E-Print Network [OSTI]

    BE 760 Structural Bioinformatics ENG BE 767 Systems Biology ENG BE 777 Computational Genomics I B Area: A. Computational and Systems Biology Course A. Computational and Systems Biology ENG BE 505 Molecular Bioengineering I ENG BE 561 DNA

  14. Lead exposures and biological responses in military weapons systems: Aerosol characteristics and acute lead effects among US Army artillerymen: Final report

    SciTech Connect (OSTI)

    Bhattacharyya, M.H.; Stebbings, J.H.; Peterson, D.P.; Johnson, S.A.; Kumar, R.; Goun, B.D.; Janssen, I.; Trier, J.E.

    1993-03-01T23:59:59.000Z

    This study was to determine the concentration and chemical nature of lead (Pb) aerosols produced during the firing of artillery and to determine the exposures and biological responses of crew members exposed to lead aerosols during such firing. The concentrations of lead-containing aerosols at crew positions depended on wind conditions, with higher concentrations when firing into a head wind. Aerosol concentrations were highest in the muzzle blast zone. Concentrations of lead in the blood of crew members rose during the first 12 days of exposure to elevated airborne lead concentrations and then leveled off. There was no rapid decrease in blood lead concentrations after completion of firing. Small decreases in hematocrit and small increases in free erythrocyte porphyrin were correlated with increasing exposure to airborne lead. These changes were reversed by seven weeks after firing. Changes in nerve conduction velocity had borderline statistical significance to airborne lead exposure. In measuring nerve conduction velocity, differences in skin temperature must be taken into account.

  15. Department of Energy Idaho - Links

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  16. NREL: Energy Analysis - Related Links

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  17. EIA - Related Links for Transportation

    Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

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  18. Related Links | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

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  19. Links | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

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  20. Links | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

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  1. Related Links | Department of Energy

    Office of Environmental Management (EM)

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  2. Related Links | Department of Energy

    Office of Environmental Management (EM)

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  3. Website Policies / Important Links | Geothermal

    Office of Scientific and Technical Information (OSTI)

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  4. Website Policies / Important Links | DOEpatents

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  5. Website Policies / Important Links | DOEpatents

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  6. Related Links | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

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  7. Related Links | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

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  8. Fermilab at Work | Physics Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField8,Dist.New Mexico Feb. 13, 2013 NAME:Job Opportunities Join thePolicies

  9. AlumniLink: January 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  10. AlumniLink: July 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  11. AlumniLink: March 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  12. AlumniLink: May 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  13. AlumniLink: November 2014

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  14. AlumniLink: September 2014

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  15. Beryllium Related Links - Hanford Site

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  16. Bisfuel links - Arizona State University

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  17. Bisfuel links - Department of Energy

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  18. Bisfuel links - Solar energy news

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  19. astro_links2.dvi

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrincetonUsingWhatY-12ZeroVariations ofSenior AcceleratorApril 6,

  20. TAMU Websites - Links - Cyclotron Institute

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  1. Related Links | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    About Us Our Programs Defense Programs Future Science & Technology Programs Advanced Simulation and Computing and Institutional R&D Programs Related Links Related Links...

  2. Validation of biological models with Temporal Logic and Timed Hybrid Sylvie Troncale, Jean-Paul Comet and Gilles Bernot

    E-Print Network [OSTI]

    Boyer, Edmond

    shown its convenience for modelling biological systems. This class of models has been fruitfully applied by a well suited model- checking procedure. I. INTRODUCTION Systems biology is aiming to a system the construction of models of a large range of complex biological systems [4]. In this paper, we describe

  3. An improved understanding of fluorescent Zn(II) sensors and their uses in biological settings

    E-Print Network [OSTI]

    Wong, Brian Alexander

    2009-01-01T23:59:59.000Z

    Chapter 1. An Introduction to Fluorescent Zn(II) Sensors and Their Applications in Biological Systems This chapter opens with an overview of the numerous roles of zinc in biology, with an emphasis on labile Zn(II), that ...

  4. Linked and Knotted Gravitational Radiation

    E-Print Network [OSTI]

    Amy Thompson; Joe Swearngin; Dirk Bouwmeester

    2014-08-15T23:59:59.000Z

    We show that the torus knot topology is inherent in electromagnetic and gravitational radiation by constructing spin-$N$ fields based on this topology from the elementary states of twistor theory. The twistor functions corresponding to the elementary states admit a parameterization in terms of the poloidal and toroidal winding numbers of the torus knots, allowing one to choose the degree of linking or knotting of the associated field configuration. Using the gravito-electromagnetic formalism, we show that the torus knot structure is exhibited in the tendex and vortex lines for the analogous linearized gravitational solutions. We describe the topology of the gravitational fields and its physical interpretation in terms of the tidal and frame drag forces of the gravitational field.

  5. Modular Information Hiding and Type-Safe Linking for C

    E-Print Network [OSTI]

    Hicks, Michael

    , CMOD, software reliability. Ç 1 INTRODUCTION MODULE systems allow large programs to be constructed from the reliability of software [32]. While full-featured module systems are part of many modern languages (such as MLModular Information Hiding and Type-Safe Linking for C Saurabh Srivastava, Student Member, IEEE

  6. Sandia National Laboratories: Industry Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Trough Systems CLFR Power Towers Acciona Abengoa Sener Solar Millennium SkyFuel Siemens Ausra SPGMann SkyFuel Abengoa Brightsource Energy SolarReserve eSolar Dish Engine...

  7. Link adaptation for energy-efficient uplink coordinated multi-point receptions

    E-Print Network [OSTI]

    Nam, Young-Han; Lie, Lingjia; Miao, Guowang; Zhang, Charlie Jianzhong

    2011-11-23T23:59:59.000Z

    We investigate link adaptation methods for energy-efficient uplink coordinated multi-point receptions. A system model for practical cellular networks is introduced, in which only a subset of base stations participates in cooperative link adaptation...

  8. Quantum metrology and its application in biology

    E-Print Network [OSTI]

    Michael A. Taylor; Warwick P. Bowen

    2014-09-03T23:59:59.000Z

    Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance in biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context. The understanding of quantum mechanics developed over the past century has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). With the birth of quantum information science came the realization that an even greater range of applications arise from the ability to not just understand, but to engineer coherence and correlations in systems at the quantum level. In quantum metrology, quantum coherence and quantum correlations are engineered to enable new approaches to sensing. This review focusses specifically on optical quantum metrology, where states of light that exhibit non-classical photon correlations are used to overcome practical and fundamental constraints, such as the shot-noise and diffraction limits. Recent experiments have demonstrated quantum enhanced sensing of biological systems, and established the potential for quantum metrology in biophysical research. These experiments have achieved capabilities that may be of significant practical benefit, including enhanced sensitivity and resolution, immunity to imaging artifacts, and characterisation of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications.

  9. Characterization and Control of Biological Microrobots

    E-Print Network [OSTI]

    magnetic system is five orders-of-magnitude less than the propulsion force gener- ated by the flagellum proposed for propulsion: extracting energy from an ex- ternal magnetic field [4], or extracting energy from of Magnetotactic Bacterium (MTB) which can be considered as a biological microrobot. Magnetic dipole moment

  10. Deposition of Biological Aerosols on HVAC Heat Exchangers

    E-Print Network [OSTI]

    LBNL-47669 Deposition of Biological Aerosols on HVAC Heat Exchangers Jeffrey Siegel and Iain Walker of Biological Aerosols on HVAC Heat Exchangers Jeffrey A. Siegel Iain S. Walker, Ph.D. ASHRAE Student Member that are found in commercial and residential HVAC systems of 1 - 6 m/s (200 - 1200 ft/min), particle diameters

  11. A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

    E-Print Network [OSTI]

    Raines, Ronald T.

    Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, infantile CI deficiency. Our results have important implications for under- standing CI function-onset neurodegeneration and is a likely contributor to cancer and type II diabetes (DiMauro and Schon, 2003; Lowell

  12. Fishery Biology Graduate Programs

    E-Print Network [OSTI]

    Fishery Biology Graduate Programs University of Alaska Fairbanks, Alaska 997750820 Program/degrees/index.html University of Arizona Tucson, Arizona 95721 Program: Fisheries Conservation and Management http://ag.arizona.edu/srnr/academicprograms/wildlifefisheries/gradstudiesFisheries.html Auburn University Auburn, Alabama 368490001 Programs: Aquaculture, Aquatic Ecology, Fishery Management

  13. BIOLOGICAL ANALYSIS Mass Spectrometry

    E-Print Network [OSTI]

    Greenaway, Alan

    Microscope) Analytical Equipment · High Performance Liquid Chromatography · Fast Protein Liquid Chromatography · Gas Chromatography · GC/MS · Elemental Analyser Molecular Biology Equipment · Biorad PCR Machine reactor for scale up studies In-line Particle sizers Rheometers Separation tanks Oscillating column (4m

  14. Chemistry and Chemical Biology

    E-Print Network [OSTI]

    Linhardt, Robert J.

    and interdisciplinary areas, including biochemical solar energy research, artificial photosynthesis and bio Biology at Rensselaer invites applications from students interested in pursuing a Ph.D. degree in an interdisciplinary environment with research opportunities in emerging fields, such as energy and the environment

  15. Biological and Environmental

    E-Print Network [OSTI]

    and sustainable biofuel but will also advance our understanding in areas of fundamental biological science. After capitalize on recent technological and scientific advances. Several multidisciplinary projects of key,ecosystemmonitoringandrestoration,combiningcropresearchandmicrobial engineering to make biofuels a viable alternative to fossil fuels, and personalized medicine to improve health

  16. Biological and Environmental Research

    E-Print Network [OSTI]

    recalcitrance. Using an integrated approach to solving the challenge of producing biofuel from cellulosic materials, the center will not only provide the scientific basis for affordable and sustainable biofuel but will also advance our understanding in areas of fundamental biological science. BESC researchers have

  17. CANCER BIOLOGY Infectioustumourcells

    E-Print Network [OSTI]

    Nowak, Martin A.

    CANCER BIOLOGY Infectioustumourcells David Dingli and Martin A. Nowak Cancer cells are generally infectious agents and be transmitted between individuals. The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer- promoting

  18. ECOLOGY LABORATORY BIOLOGY 341

    E-Print Network [OSTI]

    Vonessen, Nikolaus

    Page 1 ECOLOGY LABORATORY BIOLOGY 341 Fall Semester 2008 Bighorn Sheep Rams at Bison Range National ecological data; and 3) oral and written communication skills. Thus, these ecology labs, and statistical analyses appropriate for ecological data. A major goal of this class will be for you to gain

  19. BirdWatch--Supporting Citizen Scientists for Better Linked Data Quality for Biodiversity

    E-Print Network [OSTI]

    Hyvönen, Eero

    quality in a citizen science setting, and presents a mobile tool BirdWatch for citizen observers, miti be initiated. In many areas of biology, much of the observational data is based on citizen science: the dataBirdWatch--Supporting Citizen Scientists for Better Linked Data Quality for Biodiversity Management

  20. Chemistry & Biology Hemoglobin Digestion in Blood-Feeding Ticks

    E-Print Network [OSTI]

    Bogyo, Matthew

    Chemistry & Biology Article Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase: mares@uochb.cas.cz DOI 10.1016/j.chembiol.2009.09.009 SUMMARY Hemoglobin digestion is an essential transmission is linked to the physiology of blood feeding and digestion. Blood provides a rich source

  1. A View to the FutureBERKELEY LAB 2005/2006 REPORT A Note from the Director / 2 Energy Technologies and Environmental Solutions / 4 Living Systems and Quantitative Biology / 8 Frontiers in Nanoscience / 12 Exploring Matter and Energy in the Universe / 16

    E-Print Network [OSTI]

    Knowles, David William

    A View to the FutureBERKELEY LAB 2005/2006 REPORT #12;A Note from the Director / 2 Energy Technologies and Environmental Solutions / 4 Living Systems and Quantitative Biology / 8 Frontiers in Nanoscience / 12 Exploring Matter and Energy in the Universe / 16 X-Ray and Ultrafast Science / 20 Advanced

  2. Unraveling pancreatic islet biology by quantitative proteomics

    SciTech Connect (OSTI)

    Zhou, Jianying; Dann, Geoffrey P.; Liew, Chong W.; Smith, Richard D.; Kulkarni, Rohit N.; Qian, Weijun

    2011-08-01T23:59:59.000Z

    The pancreatic islets of Langerhans play a critical role in maintaining blood glucose homeostasis by secreting insulin and several other important peptide hormones. Impaired insulin secretion due to islet dysfunction is linked to the pathogenesis underlying both Type 1 and Type 2 diabetes. Over the past 5 years, emerging proteomic technologies have been applied to dissect the signaling pathways that regulate islet functions and gain an understanding of the mechanisms of islet dysfunction relevant to diabetes. Herein, we briefly review some of the recent quantitative proteomic studies involving pancreatic islets geared towards gaining a better understanding of islet biology relevant to metabolic diseases.

  3. Biological & Environmental Research Abstracts Database

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilAElectronic Input Options Garyand TechnicalAbout AboutWelcome to the Biological and

  4. Computational Biology | Supercomputing & Computation | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration would like submit theInnovationComputational Biology SHARE Computational

  5. SC e-journals, Biology/Genetics

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem Not Found Item Not Foundenhancer activity thanBiology/Genetics ACM Transactions on

  6. Biology and Soft Matter | Neutron Sciences | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials Find Find More LikeAndreasHelp(SC) Biological

  7. Algal Biology Program at Los Alamos

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041cloth DocumentationProducts (VAP) VAP7-0973ManagedStrategic| NationalAlexanderAlgal Biology Program

  8. Biological Hydrogen Production Workshop | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube platform isEnergyMeeting | DepartmentBioenergyUS DepartmentBiological

  9. Roadmap: Environmental and Conservation Biology Conservation Biology Bachelor of Science

    E-Print Network [OSTI]

    Sheridan, Scott

    Roadmap: Environmental and Conservation Biology ­Conservation Biology Bachelor of Science [AS Geology Elective 3-4 See note 2 on page 2 General Elective 4 #12;Roadmap: Environmental and Conservation Summary on page 2 Conservation Biology Concentration Elective 2 See note 3 on page 2 Semester Five: [15

  10. Guest Editors' Introduction: Synthetic Biology

    E-Print Network [OSTI]

    Densmore, Douglas

    + undergraduate participants from around the world. Synthetic Biology had a global market which gene- rated $233 Tufts University h SYNTHETIC BIOLOGY IS trending, as evidenced by the recent achievements in biofuels

  11. Modular architecture in biological networks

    E-Print Network [OSTI]

    Ramachandran, Gopal (Gopal Sebastian)

    2007-01-01T23:59:59.000Z

    In the past decade, biology has been revolutionized by an explosion in the availability of data. Translating this new wealth of information into meaningful biological insights and clinical breakthroughs will require a ...

  12. Biological Engineering integrates life sciences

    E-Print Network [OSTI]

    Walter, M.Todd

    mitigating 40 million pounds of carbon dioxide greenhouse gases each year, and would pay for itself in les with the constantly evolving science of biology, the field of Biological Engineering tackles local, national

  13. Developmental Plasticity Links Local Adaptation and Evolutionary

    E-Print Network [OSTI]

    Badyaev, Alex

    Developmental Plasticity Links Local Adaptation and Evolutionary Diversification in Foraging, University of Arizona, Tucson, Arizona Developmental plasticity is thought to reconcile the constraining role morphology into adulthood, providing an opportunity to directly examine the links between plasticity of bone

  14. Retroactivity, modularity, and insulation in synthetic biology circuits

    E-Print Network [OSTI]

    Lin, Allen

    2011-01-01T23:59:59.000Z

    A central concept in synthetic biology is the reuse of well-characterized modules. Modularity simplifies circuit design by allowing for the decomposition of systems into separate modules for individual construction. Complex ...

  15. Scalable computational architecture for integrating biological pathway models

    E-Print Network [OSTI]

    Shiva, V. A

    2007-01-01T23:59:59.000Z

    A grand challenge of systems biology is to model the cell. The cell is an integrated network of cellular functions. Each cellular function, such as immune response, cell division, metabolism or apoptosis, is defined by an ...

  16. Phosphorescent semiconductor nanocrystals and proteins for biological oxygen sensing

    E-Print Network [OSTI]

    McLaurin, Emily J. (Emily Jane)

    2011-01-01T23:59:59.000Z

    Oxygen is required for cellular respiration by all complex life making it a key metabolic profiling factor in biological systems. Tumors are defined by hypoxia (low pO2), which has been shown to influence response to ...

  17. Biological Interactions and Dynamics Workshop | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biological Interactions and Dynamics Workshop Biological Interactions and Dynamics Workshop Wiley HS, Kaplan S. 2011. "Biological Interactions and Dynamics Science Theme Advisory...

  18. 2013 Biological Hydrogen Production Workshop Summary Report ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Biological Hydrogen Production Workshop Summary Report 2013 Biological Hydrogen Production Workshop Summary Report November 2013 summary report for the 2013 Biological Hydrogen...

  19. Environmental Biology | Clean Energy | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    microbiology, biogeochemistry, molecular biology, molecular dynamics, bioinformatics, genomics, neutron science, chemistry, and computing-and spans multiple scales, from the...

  20. Perspectives Computational Biology in Brazil

    E-Print Network [OSTI]

    Neshich, Goran

    Perspectives Computational Biology in Brazil Goran Neshich Introduction At the request of the PLoS Computational Biology Editor-in- Chief, I agreed to write about computational biology in Brazil (see author of the field itself is short); b) the current state of the field in Brazil; c) the influence of computational

  1. COMPUTATIONAL MOLECULAR BIOLOGY TRAINING PROGRAM

    E-Print Network [OSTI]

    Mayfield, John

    in the burgeoning fields of bioinformatics and computational biology. A major outcome of the initial funding period was the establishment of ISU's interdepartmental graduate program in Bioinformatics and Computational Biology (BCB for Research Excellence in Bioinformatics and Computational Biology (BCB). The ISU-NMSU partnership

  2. Biological particle identification apparatus

    DOE Patents [OSTI]

    Salzman, Gary C. (Los Alamos, NM); Gregg, Charles T. (Los Alamos, NM); Grace, W. Kevin (Los Alamos, NM); Hiebert, Richard D. (Los Alamos, NM)

    1989-01-01T23:59:59.000Z

    An apparatus and method for making multiparameter light scattering measurements from suspensions of biological particles is described. Fourteen of the sixteen Mueller matrix elements describing the particles under investigation can be substantially individually determined as a function of scattering angle and probing radiations wavelength, eight elements simultaneously for each of two apparatus configurations using an apparatus which incluees, in its simplest form, two polarization modulators each operating at a chosen frequency, one polarizer, a source of monochromatic electromagnetic radiation, a detector sensitive to the wavelength of radiation employed, eight phase-sensitive detectors, and appropriate electronics. A database of known biological particle suspensions can be assembled, and unknown samples can be quickly identified once measurements are performed on it according to the teachings of the subject invention, and a comparison is made with the database.

  3. The conclusion of a biologic's lifecycle : manufacturing sourcing strategies on the eve of follow-on biologics

    E-Print Network [OSTI]

    Pasanek, David M

    2008-01-01T23:59:59.000Z

    The Amgen Rhode Island facility is dedicated to the production of the biological bulk drug substance (BDS) for Enbrel® (etanercept), which blocks the action of one's immune system, helping to treat immune diseases, such ...

  4. Photo-activated biological processes as quantum measurements

    E-Print Network [OSTI]

    Atac Imamoglu; K. Birgitta Whaley

    2014-08-21T23:59:59.000Z

    We outline a framework for describing photo-activated biological reactions as generalized quantum measurements of external fields, for which the biological system takes on the role of a quantum meter. By using general arguments regarding the Hamiltonian that describes the measurement interaction, we identify the cases where it is essential for a complex chemical or biological system to exhibit non-equilibrium quantum coherent dynamics in order to achieve the requisite functionality. We illustrate the analysis by considering measurement of the solar radiation field in photosynthesis and measurement of the earth's magnetic field in avian magnetoreception.

  5. Feedstock Supply System Design and Economics for Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels: Conversion Pathway: Biological Conversion of Sugars to Hydrocarbons The 2017 Design Case

    SciTech Connect (OSTI)

    Kevin Kenney; Kara G. Cafferty; Jacob J. Jacobson; Ian J Bonner; Garold L. Gresham; William A. Smith; David N. Thompson; Vicki S. Thompson; Jaya Shankar Tumuluru; Neal Yancey

    2013-09-01T23:59:59.000Z

    The U.S. Department of Energy promotes the production of a range of liquid fuels and fuel blendstocks from lignocellulosic biomass feedstocks by funding fundamental and applied research that advances the state of technology in biomass collection, conversion, and sustainability. As part of its involvement in this program, the Idaho National Laboratory (INL) investigates the feedstock logistics economics and sustainability of these fuels. Between 2000 and 2012, INL conducted a campaign to quantify the economics and sustainability of moving biomass from standing in the field or stand to the throat of the biomass conversion process. The goal of this program was to establish the current costs based on conventional equipment and processes, design improvements to the current system, and to mark annual improvements based on higher efficiencies or better designs. The 2012 programmatic target was to demonstrate a delivered biomass logistics cost of $35/dry ton. This goal was successfully achieved in 2012 by implementing field and process demonstration unit-scale data from harvest, collection, storage, preprocessing, handling, and transportation operations into INL’s biomass logistics model. Looking forward to 2017, the programmatic target is to supply biomass to the conversion facilities at a total cost of $80/dry ton and on specification with in-feed requirements. The goal of the 2017 Design Case is to enable expansion of biofuels production beyond highly productive resource areas by breaking the reliance of cost-competitive biofuel production on a single, abundant, low-cost feedstock. If this goal is not achieved, biofuel plants are destined to be small and/or clustered in select regions of the country that have a lock on low-cost feedstock. To put the 2017 cost target into perspective of past accomplishments of the cellulosic ethanol pathway, the $80 target encompasses total delivered feedstock cost, including both grower payment and logistics costs, while meeting all conversion in-feed quality targets. The 2012 $35 programmatic target included only logistics costs with a limited focus on biomass quality

  6. Linking Automated Data Analysis and Visualization with Applications in Developmental Biology and High-Energy Physics

    E-Print Network [OSTI]

    Ruebel, Oliver

    2010-01-01T23:59:59.000Z

    Without compression, the size of a bitmap index increasesnumber of bitmaps per index. Compression is used to reduceindex software called FastBit [51]. FastBit implements the fastest known bitmap compression

  7. Visual Attention to Reproductively Relevant Stimuli: The Role of Sex-Linked Biological and Social Factors

    E-Print Network [OSTI]

    Charles, Nora

    2012-02-14T23:59:59.000Z

    are included in the DSM-IV-TR diagnostic criteria for Borderline Personality Disorder (BPD; American Psychiatric Association, 2000). The presence of BPD features is also associated with younger age at first sexual activity (Sansone, Barnes, Muennich...

  8. Linking Automated Data Analysis and Visualization with Applications in Developmental Biology and High-Energy Physics

    E-Print Network [OSTI]

    Ruebel, Oliver

    2010-01-01T23:59:59.000Z

    1984, pp. 312– [13] E. J. Wegman, “Hyperdimensional dataVerlag, 2008. [16] E. Wegman and Q. Luo, “High dimensional18] R. Moustafa and E. Wegman, “On some generalization to

  9. Grays River Watershed and Biological Assessment Final Report 2006.

    SciTech Connect (OSTI)

    May, Christopher W.; McGrath, Kathleen E.; Geist, David R. [Pacific Northwest National Laboratory; Abbe, Timothy; Barton, Chase [Herrera Environmental Consultants, Inc.

    2008-02-04T23:59:59.000Z

    The Grays River Watershed and Biological Assessment was funded to address degradation and loss of spawning habitat for chum salmon (Onchorhynchus keta) and fall Chinook salmon (Onchoryhnchus tshawytscha). In 1999, the National Marine Fisheries Service listed lower Columbia River chum salmon as a threatened Evolutionarily Significant Unit (ESU) under the Endangered Species Act of 1973 (ESA). The Grays River watershed is one of two remaining significant chum salmon spawning locations in this ESU. Runs of Grays River chum and Chinook salmon have declined significantly during the past century, largely because of damage to spawning habitat associated with timber harvest and agriculture in the watershed. In addition, approximately 20-25% of the then-remaining chum salmon spawning habitat was lost during a 1999 channel avulsion that destroyed an important artificial spawning channel operated by the Washington Department of Fish and Wildlife (WDFW). Although the lack of stable, high-quality spawning habitat is considered the primary physical limitation on Grays River chum salmon production today, few data are available to guide watershed management and channel restoration activities. The objectives of the Grays River Watershed and Biological Assessment project were to (1) perform a comprehensive watershed and biological analysis, including hydrologic, geomorphic, and ecological assessments; (2) develop a prioritized list of actions that protect and restore critical chum and Chinook salmon spawning habitat in the Grays River based on comprehensive geomorphic, hydrologic, and stream channel assessments; and (3) gain a better understanding of chum and Chinook salmon habitat requirements and survival within the lower Columbia River and the Grays River. The watershed-based approach to river ecosystem restoration relies on a conceptual framework that describes general relationships between natural landscape characteristics, watershed-scale habitat-forming processes, aquatic habitat conditions, and biological integrity. In addition, human land-use impacts are factored into the conceptual model because they can alter habitat quality and can disrupt natural habitat-forming processes. In this model (Figure S.1), aquatic habitat--both instream and riparian--is viewed as the link between watershed conditions and biologic responses. Based on this conceptual model, assessment of habitat loss and the resultant declines in salmonid populations can be conducted by relating current and historical (e.g., natural) habitat conditions to salmonid utilization, diversity, and abundance. In addition, assessing disrupted ecosystem functions and processes within the watershed can aid in identifying the causes of habitat change and the associated decline in biological integrity. In this same way, restoration, enhancement, and conservation projects can be identified and prioritized. A watershed assessment is primarily a landscape-scale evaluation of current watershed conditions and the associated hydrogeomorphic riverine processes. The watershed assessment conducted for this project focused on watershed processes that form and maintain salmonid habitat. Landscape metrics describing the level of human alteration of natural ecosystem attributes were used as indicators of water quality, hydrology, channel geomorphology, instream habitat, and biotic integrity. Ecological (watershed) processes are related to and can be predicted based on specific aspects of spatial pattern. This study evaluated the hydrologic regime, sediment delivery regime, and riparian condition of the sub-watersheds that comprise the upper Grays River watershed relative to their natural range of conditions. Analyses relied primarily on available geographic information system (GIS) data describing landscape characteristics such as climate, vegetation type and maturity, geology and soils, topography, land use, and road density. In addition to watershed-scale landscape characteristics, the study area was also evaluated on the riparian scale, with appropriate landscape variables analyzed within

  10. Grays River Watershed and Biological Assessment, 2006 Final Report.

    SciTech Connect (OSTI)

    May, Christopher; Geist, David [Pacific Northwest National Laboratory

    2007-04-01T23:59:59.000Z

    The Grays River Watershed and Biological Assessment was funded to address degradation and loss of spawning habitat for chum salmon (Onchorhynchus keta) and fall Chinook salmon (Onchoryhnchus tshawytscha). In 1999, the National Marine Fisheries Service listed lower Columbia River chum salmon as a threatened Evolutionarily Significant Unit (ESU) under the Endangered Species Act of 1973 (ESA). The Grays River watershed is one of two remaining significant chum salmon spawning locations in this ESU. Runs of Grays River chum and Chinook salmon have declined significantly during the past century, largely because of damage to spawning habitat associated with timber harvest and agriculture in the watershed. In addition, approximately 20-25% of the then-remaining chum salmon spawning habitat was lost during a 1999 channel avulsion that destroyed an important artificial spawning channel operated by the Washington Department of Fish and Wildlife (WDFW). Although the lack of stable, high-quality spawning habitat is considered the primary physical limitation on Grays River chum salmon production today, few data are available to guide watershed management and channel restoration activities. The objectives of the Grays River Watershed and Biological Assessment project were to (1) perform a comprehensive watershed and biological analysis, including hydrologic, geomorphic, and ecological assessments; (2) develop a prioritized list of actions that protect and restore critical chum and Chinook salmon spawning habitat in the Grays River based on comprehensive geomorphic, hydrologic, and stream channel assessments; and (3) gain a better understanding of chum and Chinook salmon habitat requirements and survival within the lower Columbia River and the Grays River. The watershed-based approach to river ecosystem restoration relies on a conceptual framework that describes general relationships between natural landscape characteristics, watershed-scale habitat-forming processes, aquatic habitat conditions, and biological integrity. In addition, human land-use impacts are factored into the conceptual model because they can alter habitat quality and can disrupt natural habitat forming processes. In this model (Figure S.1), aquatic habitat--both instream and riparian--is viewed as the link between watershed conditions and biologic responses. Based on this conceptual model, assessment of habitat loss and the resultant declines in salmonid populations can be conducted by relating current and historical (e.g., natural) habitat conditions to salmonid utilization, diversity, and abundance. In addition, assessing disrupted ecosystem functions and processes within the watershed can aid in identifying the causes of habitat change and the associated decline in biological integrity. In this same way, restoration, enhancement, and conservation projects can be identified and prioritized. A watershed assessment is primarily a landscape-scale evaluation of current watershed conditions and the associated hydrogeomorphic riverine processes. The watershed assessment conducted for this project focused on watershed processes that form and maintain salmonid habitat. Landscape metrics describing the level of human alteration of natural ecosystem attributes were used as indicators of water quality, hydrology, channel geomorphology, instream habitat, and biotic integrity. Ecological (watershed) processes are related to and can be predicted based on specific aspects of spatial pattern. This study evaluated the hydrologic regime, sediment delivery regime, and riparian condition of the sub-watersheds that comprise the upper Grays River watershed relative to their natural range of conditions. Analyses relied primarily on available geographic information system (GIS) data describing landscape characteristics such as climate, vegetation type and maturity, geology and soils, topography, land use, and road density. In addition to watershed-scale landscape characteristics, the study area was also evaluated on the riparian scale, with appropriate landscape variables analyzed within

  11. 7.013 Introductory Biology, Spring 2005

    E-Print Network [OSTI]

    Sive, Hazel L.

    The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological ...

  12. Nov. 21, 1999 Neutron Irradiation Tests of an S-LINK-over-G-link System

    E-Print Network [OSTI]

    and the setting was downloaded to the LDC card through its computer connection. The pattern used for this test had compared in the LDC to the expected pattern and only transmitted to the monitoring computer in case flux at the center of the card was 3.0×1011 n/cm2 /day. The LDC card was placed in a low radiation

  13. Blog Distillation via Sentiment-Sensitive Link Analysis

    E-Print Network [OSTI]

    Sebastiani, Fabrizio

    Blog Distillation via Sentiment-Sensitive Link Analysis Giacomo Berardi, Andrea Esuli, Fabrizio report a new approach to blog distillation, defined as the task in which, given a user query, the system of the TREC Blog Track. 1 Introduction Blog distillation is a subtask of the blog search task. It is defined

  14. Coding analysis of the IS-95A reverse link

    E-Print Network [OSTI]

    Amin, Noor Rajib

    1999-01-01T23:59:59.000Z

    The IS-95A reverse link CDMA system is analyzed from a channel coding point of view. Analytical performance is derived for the Viterbi decoder to perform hard decision decoding. A dual-max decoding metric is suggested to provide soft information...

  15. Autofermentative Biological Hydrogen Production by Cyanobacteria...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Autofermentative Biological Hydrogen Production by Cyanobacteria Autofermentative Biological Hydrogen Production by Cyanobacteria Presentation by Charles Dismukes, Rutgers...

  16. Department of Chemical and Biological Engineering Department of Chemical and Biological Engineering

    E-Print Network [OSTI]

    Heller, Barbara

    Dynamics Lab Fuel Cell Lab Fuel Cell Battery Lab Fluidization Lab Gas Processing Lab Interfacial Phenomena: Energy and Sustainability Fuel Cells Fluidization and Gasification Hybrid Systems Biological Engineering Lab Process Control & Optimization Lab Process Modeling, Monitoring and Control Lab Rheology Lab Riser

  17. Detection and treatment of chemical weapons and/or biological pathogens

    DOE Patents [OSTI]

    Mariella Jr., Raymond P.

    2004-09-07T23:59:59.000Z

    A system for detection and treatment of chemical weapons and/or biological pathogens uses a detector system, an electrostatic precipitator or scrubber, a circulation system, and a control. The precipitator or scrubber is activated in response to a signal from the detector upon the detection of chemical weapons and/or biological pathogens.

  18. Enabling tools for biological analysis : technologies for the study of protein dynamics, detection and interaction

    E-Print Network [OSTI]

    Anwar, Moshiur Mekhail

    2007-01-01T23:59:59.000Z

    The study of proteins in biological systems requires a comprehensive approach: investigating dynamics, interaction and identification. This thesis will examine several technological approaches we have developed to address ...

  19. A deterministic, gigabit serial timing, synchronization and data link for the RHIC LLRF

    SciTech Connect (OSTI)

    Hayes, T.; Smith, K.S.; Severino, F.

    2011-03-28T23:59:59.000Z

    A critical capability of the new RHIC low level rf (LLRF) system is the ability to synchronize signals across multiple locations. The 'Update Link' provides this functionality. The 'Update Link' is a deterministic serial data link based on the Xilinx RocketIO protocol that is broadcast over fiber optic cable at 1 gigabit per second (Gbps). The link provides timing events and data packets as well as time stamp information for synchronizing diagnostic data from multiple sources. The new RHIC LLRF was designed to be a flexible, modular system. The system is constructed of numerous independent RF Controller chassis. To provide synchronization among all of these chassis, the Update Link system was designed. The Update Link system provides a low latency, deterministic data path to broadcast information to all receivers in the system. The Update Link system is based on a central hub, the Update Link Master (ULM), which generates the data stream that is distributed via fiber optic links. Downstream chassis have non-deterministic connections back to the ULM that allow any chassis to provide data that is broadcast globally.

  20. Career Mentor Link For all queries related to the Career Mentor Link

    E-Print Network [OSTI]

    Tobar, Michael

    Career Mentor Link For all queries related to the Career Mentor Link program, contact: Jo Hocking Career Mentor Link Coordinator The University of Western Australia M302, 35 Stirling Highway, Crawley WA.careers.uwa.edu.au CRICOS Provider Code: 00126G CC.005.2009 FAQs What are the time commitments? The Career Mentor Link

  1. Career Mentor Link For all queries related to the Career Mentor Link

    E-Print Network [OSTI]

    Tobar, Michael

    Career Mentor Link For all queries related to the Career Mentor Link programme, contact: Jo Hocking Career Mentor Link Coordinator The University of Western Australia M302, 35 Stirling Highway, Crawley WA! Career Mentor Link ­ Singapore is open to currently enrolled final year UWA students who are returning

  2. Biological Imaging by Soft X-Ray Diffraction Microscopy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials Find Find More LikeAndreasHelp TableBiologicalBiological

  3. Biological Imaging by Soft X-Ray Diffraction Microscopy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisiting the TWP TWPAlumniComplexMaterialProduction PetraBiologicalBiological

  4. Radiation physics, biophysics, and radiation biology

    SciTech Connect (OSTI)

    Hall, E.J.; Zaider, M.

    1993-05-01T23:59:59.000Z

    Research at the Center for Radiological Research is a multidisciplenary blend of physics, chemistry and biology aimed at understanding the mechanisms involved in the health problems resulting from human exposure to ionizing radiations. The focus is increased on biochemistry and the application of the techniques of molecular biology to the problems of radiation biology. Research highlights of the program from the past year are described. A mathematical model describing the production of single-strand and double-strand breaks in DNA as a function radiation quality has been completed. For the first time Monte Carlo techniques have been used to obtain directly the spatial distribution of DNA moieties altered by radiation. This information was obtained by including the transport codes a realistic description of the electronic structure of DNA. We have investigated structure activity relationships for the potential oncogenicity of a new generation of bioreductive drugs that function as hypoxic cytotoxins. Experimental and theoretical investigation of the inverse dose rate effect, whereby medium LET radiations actually produce an c effect when the dose is protracted, is now at a point where the basic mechanisms are reasonably understood and the complex interplay between dose, dose rate and radiation quality which is necessary for the effect to be present can now be predicted at least in vitro. In terms of early radiobiological damage, a quantitative link has been established between basic energy deposition and locally multiply damaged sites, the radiochemical precursor of DNA double strand breaks; specifically, the spatial and energy deposition requirements necessary to form LMDs have been evaluated. For the first time, a mechanically understood biological fingerprint'' of high-LET radiation has been established. Specifically measurement of the ratio of inter-to intra-chromosomal aberrations produces a unique signature from alpha-particles or neutrons.

  5. On a Model of Superconductivity and Biology

    E-Print Network [OSTI]

    Monica De Angelis

    2012-03-02T23:59:59.000Z

    The paper deals with a semilinear integrodifferential equation that characterizes several dissipative models of Viscoelasticity, Biology and Superconductivity. The initial - boundary problem with Neumann conditions is analyzed. When the source term F is a linear function, then the explicit solution is obtained. When F is non linear, some results on existence, uniqueness and a priori estimates are deduced. As example of physical model the reaction - diffusion system of Fitzhugh Nagumo is considered.

  6. Helpful links for materials transport, safety, etc.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Helpful links for materials transport, safety, etc. relating to experiment safety at the APS. Internal Reference Material: Transporting Hazardous Materials "Natural" radioactivity...

  7. Geothermal: Website Policies and Important Links

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Website Policies and Important Links Geothermal Technologies Legacy Collection HelpFAQ | Site Map | Contact Us HomeBasic Search About Publications Advanced Search New Hot Docs...

  8. optical links for the atlas pixel detector

    E-Print Network [OSTI]

    Stucci, Stefania Antonia; The ATLAS collaboration

    2015-01-01T23:59:59.000Z

    Optical links are necessary to satisfy the high speed readout over long distances for advanced silicon detector systems. We report on the optical readout used in the newly installed central pixel layer (IBL) in the ATLAS experiment. The off detector readout employs commercial optical to analog converters, which were extensively tested for this application. Performance measurements during installation and commissioning will be shown. With the increasing instantaneous luminosity in the next years, the next layers outwards of IBL of the ATLAS Pixel detector (Layer 1 and Layer 2) will reach their bandwidth limits. A plan to increase the bandwidth by upgrading the off detector readout chain is put in place. The plan also involves new optical readout components, in particular the optical receivers, for which commercial units cannot be used and a new design has been made. The latter allows for a wider operational range in term of data frequency and light input power to match the on-detector sending units on the pres...

  9. Optical links for the ATLAS Pixel detector

    E-Print Network [OSTI]

    Stucci, Stefania Antonia; The ATLAS collaboration

    2015-01-01T23:59:59.000Z

    Optical links are necessary to satisfy the high speed readout over long distances for advanced silicon detector systems. We report on the optical readout used in the newly installed central pixel layer (IBL) in the ATLAS experiment. The off detector readout employs commercial optical to analog converters, which were extensively tested for this application. Performance measurements during installation and commissioning will be shown. With the increasing instantaneous luminosity in the next years, the next layers outwards of IBL of the ATLAS Pixel detector (Layer 1 and Layer 2) will reach their bandwidth limits. A plan to increase the bandwidth by upgrading the off detector readout chain is put in place. The plan also involves new optical readout components, in particular the optical receivers, for which commercial units cannot be used and a new design has been made. The latter allows for a wider operational range in term of data frequency and light input power to match the on-detector sending units on the pres...

  10. Monte Carlo simulation in systems biology

    E-Print Network [OSTI]

    Schellenberger, Jan

    2010-01-01T23:59:59.000Z

    B.O. Candidate states of helicobacter pylori’s genome-scalereconstruction of helicobacter pylori (iit341 gsm/gpr): Ancoli core model [80] 3) Helicobacter pylori iIT341 [37] 4)

  11. Systems Biology Knowledgebase (GSC8 Meeting)

    ScienceCinema (OSTI)

    Cottingham, Robert W [ORNL

    2011-04-29T23:59:59.000Z

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Robert W. Cottingham of Oak Ridge National Laboratory discusses the DOE KnowledgeBase at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 9, 2009.

  12. Nitrogen oxide delivery systems for biological media

    E-Print Network [OSTI]

    Skinn, Brian Thomas

    2012-01-01T23:59:59.000Z

    Elevated levels of nitric oxide (NO) in vivo are associated with a variety of cellular modifications thought to be mutagenic or carcinogenic. These processes are likely mediated by reactive nitrogen species (RNS) such as ...

  13. Renewable Hydrogen Production from Biological Systems

    Broader source: Energy.gov (indexed) [DOE]

    Workshop September 24 th , 2013 H 2 production PSIIPSI pathway PSInonphotochemical PQ Dark fermentation H 2 uptake oxyhydrogen reaction photoreduction Photosynthetic H 2 pathways...

  14. Biological effectiveness of neutrons: Research needs

    SciTech Connect (OSTI)

    Casarett, G.W.; Braby, L.A.; Broerse, J.J.; Elkind, M.M.; Goodhead, D.T.; Oleinick, N.L.

    1994-02-01T23:59:59.000Z

    The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy.

  15. Track with overlapping links for dry coal extrusion pumps

    DOE Patents [OSTI]

    Saunders, Timothy; Brady, John D

    2014-01-21T23:59:59.000Z

    A chain for a particulate material extrusion pump includes a plurality of links, each of the plurality of links having a link body and a link ledge, wherein each link ledge of the plurality of links at least partially overlaps the link body of an adjacent one of the plurality of links.

  16. Biologically inspired digital fabrication

    E-Print Network [OSTI]

    Han, Sarah (Sarah J.)

    2013-01-01T23:59:59.000Z

    Objects and systems in nature are models for the practice of sustainable design and fabrication. From trees to bones, natural systems are characterized by the constant interplay of creation, environmental response, and ...

  17. Structural Molecular Biology, SSRL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over Our Instagram Secretary900SteepStrengthening northernDeterminationScience

  18. Biological & Environmental Research Abstracts Database

    Office of Scientific and Technical Information (OSTI)

    Welcome to the Administrative section of the Biological and Environmental Research Abstracts Database. Please logon. Logon Name: Password: Logon CommentsEmail Us * Security...

  19. CollegeofScience Biological Sciences

    E-Print Network [OSTI]

    Hickman, Mark

    ,populations,and even ecosystems. Our courses will help prepare you for a career in biology,be it in biodiversity

  20. COMPLEX BIOLOGICAL MECHANISMS: CYCLIC, OSCILLATORY,

    E-Print Network [OSTI]

    Bechtel, William

    COMPLEX BIOLOGICAL MECHANISMS: CYCLIC, OSCILLATORY, AND AUTONOMOUS William Bechtel and Adele- nomological framework and its focus on laws as the primary explanatory vehicle; for them, a scientific