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1

Information bias and lifetime mortality risks of radiation-induced cancer: Low LET radiation  

Science Conference Proceedings (OSTI)

Additive and multiplicative models of relative risk were used to measure the effect of cancer misclassification and DS86 random errors on lifetime risk projections in the Life Span Study (LSS) of Hiroshima and Nagasaki atomic bomb survivors. The true number of cancer deaths in each stratum of the cancer mortality cross-classification was estimated using sufficient statistics from the EM algorithm. Average survivor doses in the strata were corrected for DS86 random error ({sigma}=0.45) by use of reduction factors. Poisson regression was used to model the corrected and uncorrected mortality rates with risks in RERF Report 11 (Part 2) and the BEIR-V Report. Bias due to DS86 random error typically ranged from {minus}15% to {minus}30% for both sexes, and all sites and models. The total bias, including diagnostic misclassification, of excess risk of nonleukemia for exposure to 1 Sv from age 18 to 65 under the non-constant relative project model was {minus}37.1% for males and {minus}23.3% for females. Total excess risks of leukemia under the relative projection model were biased {minus}27.1% for males and {minus}43.4% for females. Thus, nonleukemia risks for 1 Sv from ages 18 to 65 (DRREF=2) increased from 1.91%/Sv to 2.68%/Sv among males and from 3.23%/Sv to 4.92%/Sv among females. Leukemia excess risk increased from 0.87%/Sv to 1.10/Sv among males and from 0.73%/Sv to 1.04/Sv among females. Bias was dependent on the gender, site, correction method, exposure profile and projection model considered. Future studies that use LSS data for US nuclear workers may be downwardly biased if lifetime risk projections are not adjusted for random and systematic errors.

Peterson, L.E.; Schull, W.J.; Davis, B.R. [Texas Univ., Houston, TX (United States). Health Science Center; Buffler, P.A. [California Univ., Berkeley, CA (United States). School of Public Health

1994-04-01T23:59:59.000Z

2

ENVIRONMENTAL CANCER RISK  

E-Print Network (OSTI)

This report is submitted to the President of the United States in fulfillment of the obligations of the President’s Cancer Panel to appraise the National Cancer Program as established in accordance with the National Cancer Act of 1971 (P.L. 92-218), the

Margaret L. Kripke, Ph.D.; Abby B. S, Ph.D.; Suzanne H. Reuben

2010-01-01T23:59:59.000Z

3

Low dose diagnostic radiation exposure and cancer risk in Trp53+/- mice  

NLE Websites -- All DOE Office Websites (Extended Search)

diagnostic radiation exposure and cancer risk in Trp53+/- mice diagnostic radiation exposure and cancer risk in Trp53+/- mice K Taylor, N Phan, ME Cybulski, L Laframboise, DR Boreham Department of Medical Physics and Applied Radiation Sciences, McMaster University, 1280 Main Street West, Hamilton ON L8S 4K1 The cancer risk associated with exposure to low doses of ionizing radiation has traditionally been extrapolated from effects observed at high doses and high dose rates using a linear no threshold model. Based on this approach, it has been postulated that human exposure to medical imaging involving low doses of x-rays and gamma rays increase an individual's risk of developing cancer throughout their lifetime. Conversely, there is evidence that low doses of gamma radiation increase the latency period of cancer depending upon genotype, cancer type, and the magnitude of

4

Northeast Regional Cancer Institute's Cancer Surveillance and Risk Factor Program  

Science Conference Proceedings (OSTI)

OBJECTIVES The Northeast Regional Cancer Institute is conducting a program of ongoing epidemiologic research to address cancer disparities in northeast Pennsylvania. Of particular concern are disparities in the incidence of, stage at diagnosis, and mortality from colorectal cancer. In northeast Pennsylvania, age-adjusted incidence and mortality rates for colorectal cancer are higher, and a significantly smaller proportion of new colorectal cancer cases are diagnosed with local stage disease than is observed in comparable national data. Further, estimates of the prevalence of colorectal cancer screening in northeast Pennsylvania are lower than the US average. The Northeast Regional Cancer Institute’s research program supports surveillance of common cancers, investigations of cancer risk factors and screening behaviors, and the development of resources to further cancer research in this community. This project has the following specific objectives: I. To conduct cancer surveillance in northeast Pennsylvania. a. To monitor incidence and mortality for all common cancers, and colorectal cancer, in particular, and b. To document changes in the stage at diagnosis of colorectal cancer in this high-risk, underserved community. II. To conduct a population-based study of cancer risk factors and screening behavior in a six county region of northeast Pennsylvania. a. To monitor and document changes in colorectal cancer screening rates, and b. To document the prevalence of cancer risk factors (especially factors that increase the risk of colorectal cancer) and to identify those risk factors that are unusually common in this community. APPROACH Cancer surveillance was conducted using data from the Northeast Regional Cancer Institute’s population-based Regional Cancer Registry, the Pennsylvania Cancer Registry, and NCI’s SEER program. For common cancers, incidence and mortality were examined by county within the region and compared to data for similar populations in the US. For colorectal cancer, the stage at diagnosis of cases diagnosed in northeast Pennsylvania was compared to data from prior years. A population-based interview study of healthy adults was conducted to document the status of cancer screening and to estimate the prevalence of established cancer risk factors in this community. This study is similar in design to that used by the Centers for Disease Control and Prevention’s (CDC) Behavioral Risk Factor Surveillance System (BRFSS). EXPERIMENTAL METHODS AND PROCEDURES: This program includes two distinct but related projects. The first project uses existing data to conduct cancer surveillance in northeast Pennsylvania, and the second is a population-based study of cancer risk factors and cancer screening behaviors in this same population. HUMAN SUBJECTS CONSIDERATIONS This program includes two projects: cancer surveillance and a population-based study of cancer risk factors and screening behavior. The cancer surveillance project involves only the use of existing aggregate data or de-identified data. As such, the surveillance project is exempt from human subjects considerations. The study of cancer risk factors and screening behaviors includes data from a random sample of adult residents of northeast Pennsylvania who are 18 or more years of age. All races, ethnicities and both sexes are included in proportion to their representation in the population. Subjects are interviewed anonymously by telephone; those who are unable to complete an interview in English are ineligible. This project has been reviewed and approved by the Scranton-Temple Residency Program IRB (IRB00001355), which is the IRB for the Northeast Regional Cancer Institute.

Lesko, Samuel M.

2007-07-31T23:59:59.000Z

5

Estimated Cancer Risks Associated with Dermal Exposure to Mineral Oil Containing PCB Concentrations of 50 ppm or Less  

Science Conference Proceedings (OSTI)

The excess lifetime cancer risks (ELCRs) from dermal exposures to low levels of polychlorinated biphenyls (PCBs) (that is, 50 ppm or less) in mineral oil were determined for utility workers involved in four different work activities related to mineral oil spill cleanup and the maintenance of breakers and transformers. Two risk calculations were made for each work activity: reasonable maximum exposure (RMaxE) scenarios using conservative to highly conservative parameters and central tendency exposure (CTE...

2011-08-17T23:59:59.000Z

6

Cancer risk among atomic bomb survivors. The RERF Life Span Study. Radiation Effects Research Foundation  

SciTech Connect

This article summarizes the risk of cancer among the survivors of the atomic bombing of Hiroshima and Nagasaki. We focus primarily on the risk of death from cancer among individuals in the Life Span Study sample of the Radiation Effects Research Foundation from 1950 through 1985 based on recently revised dosimetry procedures. We report the risk of cancer other than leukemia among the atomic bomb survivors. We note that the number of excess deaths of radiation-induced malignant tumors other than leukemia increases with age. Survivors who were exposed in the first or second decade of life have just entered the cancer-prone age and have so far exhibited a high relative risk in association with radiation dose. Whether the elevated risk will continue or will fall with time is not yet clear, although some evidence suggests that the risk may be declining. It is important to continue long-term follow-up of this cohort to document the changes with time since exposure and to provide direct rather than projected risks over the lifetime of an exposed individual.

Shimizu, Y.; Schull, W.J.; Kato, H. (Radiation Effects Research Foundation, Hiroshima (Japan))

1990-08-01T23:59:59.000Z

7

B Lifetime  

NLE Websites -- All DOE Office Websites (Extended Search)

B Lifetime Equation Back to Finding B Lifetime Project Contact: Thomas Jordan - jordant@fnal.gov Web Maintainer: qnet-webmaster@fnal.gov Last Update: June, 2001 http:...

8

Second cancer incidence risk estimates using BEIR VII models for standard and complex external beam radiotherapy for early breast cancer  

Science Conference Proceedings (OSTI)

Purpose: To compare organ specific cancer incidence risks for standard and complex external beam radiotherapy (including cone beam CT verification) following breast conservation surgery for early breast cancer.Method: Doses from breast radiotherapy and kilovoltage cone beam CT (CBCT) exposures were obtained from thermoluminescent dosimeter measurements in an anthropomorphic phantom in which the positions of radiosensitive organs were delineated. Five treatment deliveries were investigated: (i) conventional tangential field whole breast radiotherapy (WBRT), (ii) noncoplanar conformal delivery applicable to accelerated partial beast irradiation (APBI), (iii) two-volume simultaneous integrated boost (SIB) treatment, (iv) forward planned three-volume SIB, and (v) inverse-planned three volume SIB. Conformal and intensity modulated radiotherapy methods were used to plan the complex treatments. Techniques spanned the range from simple methods appropriate for patient cohorts with a low cancer recurrence risk to complex plans relevant to cohorts with high recurrence risk. Delineated organs at risk included brain, salivary glands, thyroid, contralateral breast, left and right lung, esophagus, stomach, liver, colon, and bladder. Biological Effects of Ionizing Radiation (BEIR) VII cancer incidence models were applied to the measured mean organ doses to determine lifetime attributable risk (LAR) for ages at exposure from 35 to 80 yr according to radiotherapy techniques, and included dose from the CBCT imaging. Results: All LAR decreased with age at exposure and were lowest for brain, thyroid, liver, and bladder (cancer incidence for organs distant from the treated breast, or the contralateral breast where appropriate plan constraints are applied. Complex SIB treatments are predicted to increase the risk of second cancer incidence in the lungs compared to standard whole breast radiotherapy; this is outweighed by the threefold reduction in 5 yr local recurrence risk for patients of high risk of recurrence, and young age, from the use of radiotherapy. APBI may have a favorable impact on risk of second cancer in the contralateral breast and lung for older patients at low risk of recurrence. Intensive use of IGRTincreased the estimated values of LAR but these are dominated by the effect of the dose from the radiotherapy, and any increase in LAR from IGRT is much lower than the models' uncertainties.

Donovan, E. M.; James, H.; Bonora, M.; Yarnold, J. R.; Evans, P. M. [Joint Department of Physics, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton SM2 5PT (United Kingdom); Physics Department, Ipswich Hospital NHS Foundation Trust, Ipswich IP4 5PD (United Kingdom); Department of Academic Radiotherapy, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton SM2 5PT, United Kingdom and School of Radiotherapy, University of Milan, Milan 20122 (Italy); Department of Academic Radiotherapy, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton SM2 5PT (United Kingdom); Centre for Vision Speech and Signal Processing, University of Surrey, Guildford GU2 7XH (United Kingdom)

2012-10-15T23:59:59.000Z

9

B Lifetime  

NLE Websites -- All DOE Office Websites (Extended Search)

Lifetime Lifetime Lifetime is similar to half-life, which you may have studied in radioactivity. More details on lifetime. Lifetime is the average time between creation and decay of a particle, which cannot be predicted for an individual particle, so we use the average time. The lifetime is the time when e-1 (or 37%) of them have survived. Derivation of equation To simplify calculations, we will use only the information in a plane perpendicular (transverse) to the beams, that is, in the x-y plane. The lifetime of B mesons is t = d/v (since velocity = distance/time) The velocity can be determined from the momentum. However, we cannot use the usual equation p = mv These particles are moving at velocities close to the speed of light, c. Here the correct formula is (Do you find the usual formula for p if v is much smaller than c?)

10

Particle Lifetimes  

NLE Websites -- All DOE Office Websites (Extended Search)

Reviewing Particle Lifetimes Reviewing Particle Lifetimes The lifetimes of elementary particles are statistical in nature. In a given sample, one particle might decay immediately, another in 1 nanosecond, yet another after 10 milliseconds, and still another in 50 years. What we call the lifetime is the time it takes for a sample to decay so 1/e (~30%) of the sample is left; after 2 lifetimes, 1/e2 of the sample is left, and so on. Take, for example, a sample of cosmic ray muons produced in the upper atmosphere. These muons, when observed at (relative) rest in the laboratory, have a mean lifetime T. Now, since particle decay is statistical in nature, the number of undecayed particles after a given time is a negative exponential function: N(t) = No e-t/T where N(t) is the number of muons at time t, No is the initial number of

11

EPA 402-R-93-076 ESTIMATING RADIOGENIC CANCER RISKS  

E-Print Network (OSTI)

, especially new information on the Japanese atomic bomb survivors. For most cancer sites, the risk model of coefficients derived from the atomic bomb survivor data employing two different methods for transporting risks 401 M Street S.W. Washington, DC 20460 #12;ii The scientific basis for this report has been reviewed

12

B Lifetime  

NLE Websites -- All DOE Office Websites (Extended Search)

Search Extra Project Find B lifetime. Found info: Source 5 Project Contact: Thomas Jordan - jordant@fnal.gov Web Maintainer: qnet-webmaster@fnal.gov Last Update: January 10,...

13

Molecular Epidemiology of Human Cancer Risk  

Science Conference Proceedings (OSTI)

Epidemiology has identified several etiological factors in lung cancer, of which the most ... Finally, most molecular epidemiology studies include genetic research.

14

Arsenic Cancer Risk Assessment: Recent Advances & Next Steps  

Science Conference Proceedings (OSTI)

In recent years, there has been an on-going debate on the appropriate regulatory approach for evaluating the carcinogenicity of inorganic arsenic compounds, specifically in the best methods and data sources for establishing a cancer potency, or cancer slope factor (CSF). The CSF is applied to the development of environmental standards, regulation and risk assessments under a variety of federal and state programs. Currently, the U.S. Environmental Protection Agency (EPA) continues to rely on chemical non-...

2011-12-30T23:59:59.000Z

15

Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk  

E-Print Network (OSTI)

Family Institute for Breast Cancer Research Ontario CancerInternational Agency for Research on Cancer, 2000. CancerThe Canadian Cancer Registries Epidemiology Research Group,

2009-01-01T23:59:59.000Z

16

Low Dose Radiation Cancer Risks: Epidemiological and Toxicological Models  

Science Conference Proceedings (OSTI)

The basic purpose of this one year research grant was to extend the two stage clonal expansion model (TSCE) of carcinogenesis to exposures other than the usual single acute exposure. The two-stage clonal expansion model of carcinogenesis incorporates the biological process of carcinogenesis, which involves two mutations and the clonal proliferation of the intermediate cells, in a stochastic, mathematical way. The current TSCE model serves a general purpose of acute exposure models but requires numerical computation of both the survival and hazard functions. The primary objective of this research project was to develop the analytical expressions for the survival function and the hazard function of the occurrence of the first cancer cell for acute, continuous and multiple exposure cases within the framework of the piece-wise constant parameter two-stage clonal expansion model of carcinogenesis. For acute exposure and multiple exposures of acute series, it is either only allowed to have the first mutation rate vary with the dose, or to have all the parameters be dose dependent; for multiple exposures of continuous exposures, all the parameters are allowed to vary with the dose. With these analytical functions, it becomes easy to evaluate the risks of cancer and allows one to deal with the various exposure patterns in cancer risk assessment. A second objective was to apply the TSCE model with varing continuous exposures from the cancer studies of inhaled plutonium in beagle dogs. Using step functions to estimate the retention functions of the pulmonary exposure of plutonium the multiple exposure versions of the TSCE model was to be used to estimate the beagle dog lung cancer risks. The mathematical equations of the multiple exposure versions of the TSCE model were developed. A draft manuscript which is attached provides the results of this mathematical work. The application work using the beagle dog data from plutonium exposure has not been completed due to the fact that the research project did not continue beyond its first year.

David G. Hoel, PhD

2012-04-19T23:59:59.000Z

17

Hiroshima and Nagasaki: New doses, risks, and their implications  

SciTech Connect

This presentation summarizes the recent re-evaluations of the dose and risk of cancer among survivors of the atomic bombing of Hiroshima and Nagasaki. It addresses briefly their limitations, and describes some of their implications for the lifetime projection of the risk of a fatal cancer following exposure to ionizing radiation.

Schull, W.J.; Shimizu, Y.; Kato, H. (Univ. of Texas Health Science Center, Houston (USA))

1990-07-01T23:59:59.000Z

18

Breast cancer risk and environmental exposures. Environ Health Perspect 105:891–896  

E-Print Network (OSTI)

Although environmental contaminants have potential to affect breast cancer risk, explicit environmental links to this disease are limited. The most well-defined environmental risk factors are radiation exposure and alcohol ingestion. Diet is clearly related to the increased incidence of breast cancer in developed countries, but its precise role is not yet established. Recent studies have implicated exposure to organochlorines including DDT as a risk factor for breast cancer in

Mary S. Wolff; Ainsley Weston

1997-01-01T23:59:59.000Z

19

Low dose diagnostic radiation exposure and cancer risk in Trp53...  

NLE Websites -- All DOE Office Websites (Extended Search)

University Abstract The cancer risk associated with exposure to low doses of ionizing radiation has traditionally been extrapolated from effects observed at high doses and high...

20

Breast Cancer and Personal Environmental Risk Factors in Marin County --  

NLE Websites -- All DOE Office Websites (Extended Search)

Breast Cancer and Personal Environmental Risk Factors in Marin County -- Breast Cancer and Personal Environmental Risk Factors in Marin County -- Pilot Study Title Breast Cancer and Personal Environmental Risk Factors in Marin County -- Pilot Study Publication Type Report Year of Publication 2003 Authors Erdmann, Christine A., Georgianna Farren, Kimberly Baltzell, Terri Chew, Cynthia Clarkson, Ruth Fleshman, Colin Leary, Mary Mizroch, Fern Orenstein, Marion L. Russell, Virginia Souders-Mason, and Margaret Wrensch Abstract The purpose of the Personal Environmental Risk Factor Study (PERFS) pilot project was to develop methodologies and a questionnaire for a future population-based case-control study to investigate the role of selected environmental exposures in breast cancer development. Identification of etiologically relevant exposures during a period of potential vulnerability proximate to disease onset offers the possibility of clinical disease prevention even when disease initiation may have already occurred many years earlier. Certain personal environmental agents or combinations of agents may influence disease promotion. Therefore, this pilot study focused on exposures that occurred during the ten-year period prior to diagnosis for cases and the last ten years for controls, rather than more historic exposures. For this pilot study, we used a community-based research approach. In our collaborative efforts, community members participated with academic researchers in all phases of the research, including research question identification, study design, development of research tools, development of the human subjects protocol, and report writing. Community member inclusion was based upon the concept that community participation could improve the relevance of scientific studies and ultimate success of the research by encouraging an ongoing dialogue between community members and academic representatives. Early activities of this project focused on the collection of input from the community regarding the possible role of environmental factors in the incidence of breast cancer in Marin County. The intent was to inform the scientists of community concerns, enhance the research team's understanding of the community being studied, and provide interested community members with a better understanding of the strengths and weaknesses of traditional research methods through active participation in the research process. This pilot study identified specific testable hypotheses through review of the literature and consultation with relevant experts and the affected community. Initially, the study was to focus on modifiable personal environmental exposures that are associated with breast tumor promotion and higher socioeconomic status (SES). However, little information was available in the scientific literature regarding the putative mechanism by which some of the suspected environmental factors may act (i.e., initiator vs. promoter). Likewise, little is known about the distribution of personal environmental risk factors by socioeconomic status. Therefore, tumor promotion involvement and association with SES were not very useful as selection criteria, and selection of topics was based primarily on published scientific findings of human studies and community input. This study was approved by the Institutional Review Boards at the University of California at San Francisco (Committee on Human Research) and at the University of California at Berkeley (Committee for the Protection of Human Subjects)

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

An optimized five-gene multi-platform predictor of hormone receptor negative and triple negative breast cancer metastatic risk  

E-Print Network (OSTI)

5 Breakthrough Breast Cancer Research Unit, Guy’ s Hospital,metastatic risk. Breast Cancer Research 2013 15:R103. SubmitYau et al. Breast Cancer Research 2013, 15:R103 http://

2013-01-01T23:59:59.000Z

22

Low Dose Radiation Research Program: The Risk of Cancer Induction Due to  

NLE Websites -- All DOE Office Websites (Extended Search)

November 10-12, 1999, Washington, D.C. November 10-12, 1999, Washington, D.C. The Risk of Cancer Induction Due to Routine Mammographic Screening Featured Project Description David J. Brenner, Steve Marino, and Charles Geard, Center for Radiological Research, Columbia University, 630 West 168th Street, New York Summary: To obtain realistic and credible risk estimates for breast-cancer mortality due to clinical mammographic imaging examinations. Abstract: The aim of this work is to obtain realistic and credible risk estimates for breast-cancer mortality due to clinical mammographic imaging examinations. Given the increasing emphasis on clinical mammographic screening for breast cancer, it is of societal importance to provide realistic risk estimates with realistic confidence bounds for breast cancer

23

Fuzzy-probabilistic multi agent system for breast cancer risk assessment and insurance premium assignment  

Science Conference Proceedings (OSTI)

In this paper, we present an agent-based system for distributed risk assessment of breast cancer development employing fuzzy and probabilistic computing. The proposed fuzzy multi agent system consists of multiple fuzzy agents that benefit from fuzzy ... Keywords: Breast cancer, Fuzzy probability, Fuzzy-probabilistic multi agent system, Insurance premium, Uncertainty

Farzaneh Tatari; Mohammad-R. Akbarzadeh-T; Ahmad Sabahi

2012-12-01T23:59:59.000Z

24

SigmaLifetime  

NLE Websites -- All DOE Office Websites (Extended Search)

uncertainty relation Et h4 and their measured energy spread E. STUDENT LEARNING OBJECTIVES 1. Lifetime of moving particles is related to track length in a bubble...

25

3.0 CANCER RISKS FROM ON-SITE EXPOSURE This chapter examines the potential scenarios, exposure pathways, and risks of cancer to humans  

E-Print Network (OSTI)

pathways, and risks of cancer to humans that may be posed by exposure to TENORM from abandoned uranium mine of uranium mine TENORM wastes,1 there are several possible exposure scenarios for humans to the various, the primary exposure scenarios to TENORM wastes at uranium mines would involve recreational use of the site

26

Serum 25-hydroxyvitamin D and risk of breast cancer  

E-Print Network (OSTI)

The relationship of solar radiation to cancer mortality ininvolving exposure to solar radiation. Prev Med. 1990;19:and amount of solar radiation in 49 US metropolitan areas

Mohr, Sharif Burgette

2012-01-01T23:59:59.000Z

27

Risk Factors Associated With Secondary Sarcomas in Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study  

Science Conference Proceedings (OSTI)

Purpose: Childhood cancer survivors have an increased risk of secondary sarcomas. To better identify those at risk, the relationship between therapeutic dose of chemotherapy and radiation and secondary sarcoma should be quantified. Methods and Materials: We conducted a nested case-control study of secondary sarcomas (105 cases, 422 matched controls) in a cohort of 14,372 childhood cancer survivors. Radiation dose at the second malignant neoplasm (SMN) site and use of chemotherapy were estimated from detailed review of medical records. Odds ratios (ORs) and 95% confidence intervals were estimated by conditional logistic regression. Excess odds ratio (EOR) was modeled as a function of radiation dose, chemotherapy, and host factors. Results: Sarcomas occurred a median of 11.8 years (range, 5.3-31.3 years) from original diagnosis. Any exposure to radiation was associated with increased risk of secondary sarcoma (OR = 4.1, 95% CI = 1.8-9.5). A dose-response relation was observed, with elevated risks at doses between 10 and 29.9 Gy (OR = 15.6, 95% CI = 4.5-53.9), 30-49.9 Gy (OR = 16.0, 95% CI 3.8-67.8) and >50 Gy (OR = 114.1, 95% CI 13.5-964.8). Anthracycline exposure was associated with sarcoma risk (OR = 3.5, 95% CI = 1.6-7.7) adjusting for radiation dose, other chemotherapy, and primary cancer. Adjusting for treatment, survivors with a first diagnosis of Hodgkin lymphoma (OR = 10.7, 95% CI = 3.1-37.4) or primary sarcoma (OR = 8.4, 95% CI = 3.2-22.3) were more likely to develop a sarcoma. Conclusions: Of the risk factors evaluated, radiation exposure was the most important for secondary sarcoma development in childhood cancer survivors; anthracycline chemotherapy exposure was also associated with increased risk.

Henderson, Tara O., E-mail: thenderson@peds.bsd.uchicago.edu [University of Chicago, Chicago, IL (United States); Rajaraman, Preetha [National Cancer Institute, Bethesda, MD (United States)] [National Cancer Institute, Bethesda, MD (United States); Stovall, Marilyn [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States)] [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States); Constine, Louis S. [University of Rochester, Rochester, NY (United States)] [University of Rochester, Rochester, NY (United States); Olive, Aliza [Drexel University, Philadelphia, PA (United States)] [Drexel University, Philadelphia, PA (United States); Smith, Susan A. [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States)] [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States); Mertens, Ann [Emory University, Atlanta, GA (United States)] [Emory University, Atlanta, GA (United States); Meadows, Anna [Children's Hospital of Philadelphia, Philadelphia, PA (United States)] [Children's Hospital of Philadelphia, Philadelphia, PA (United States); Neglia, Joseph P. [University of Minnesota, Minneapolis, MN (United States)] [University of Minnesota, Minneapolis, MN (United States); Hammond, Sue [Nationwide Children's Hospital, Columbus, OH (United States)] [Nationwide Children's Hospital, Columbus, OH (United States); Whitton, John [Fred Hutchinson Cancer Research Center, Seattle, WA (United States)] [Fred Hutchinson Cancer Research Center, Seattle, WA (United States); Inskip, Peter D. [National Cancer Institute, Bethesda, MD (United States)] [National Cancer Institute, Bethesda, MD (United States); Robison, Leslie L. [St. Jude Children's Research Hospital, Memphis, TN (United States)] [St. Jude Children's Research Hospital, Memphis, TN (United States); Diller, Lisa [Dana-Farber Cancer Institute/Children's Hospital Cancer Center, Boston, MA (United States)] [Dana-Farber Cancer Institute/Children's Hospital Cancer Center, Boston, MA (United States)

2012-09-01T23:59:59.000Z

28

Three-dimensional fluorescence lifetime tomography  

Science Conference Proceedings (OSTI)

Near-infrared fluorescence tomography using molecularly targeted lifetime-sensitive, fluorescent contrast agents have applications for early-stage cancer diagnostics. Yet, although the measurement of fluorescent lifetime imaging microscopy (FLIM) is extensively used in microscopy and spectroscopy applications, demonstration of fluorescence lifetime tomography for medical imaging is limited to two-dimensional studies. Herein, the feasibility of three-dimensional fluorescence-lifetime tomography on clinically relevant phantom volumes is established, using (i) a gain-modulated intensified charge coupled device (CCD) and modulated laser diode imaging system, (ii) two fluorescent contrast agents, e.g., Indocyanine green and 3-3'-Diethylthiatricarbocyanine iodide differing in their fluorescence lifetime by 0.62 ns, and (iii) a two stage approximate extended Kalman filter reconstruction algorithm. Fluorescence measurements of phase and amplitude were acquired on the phantom surface under different target to background fluorescence absorption (70:1, 100:1) and fluorescence lifetime (1:1, 2.1:1) contrasts at target depths of 1.4-2 cm. The Bayesian tomography algorithm was employed to obtain three-dimensional images of lifetime and absorption owing to the fluorophores.

Godavarty, Anuradha; Sevick-Muraca, Eva M.; Eppstein, Margaret J. [327 Votey Building, Department of Computer Science, University of Vermont, Burlington, Vermont 05405 (United States); 1011 Richardson Building, Photon Migration Laboratories, Texas A and M University, College Station, Texas 77843 (United States); 327 Votey Building, Department of Computer Science, University of Vermont, Burlington, Vermont 05405 (United States)

2005-04-01T23:59:59.000Z

29

Is Adjuvant Chemoradiotherapy Overtreatment in Cervical Cancer Patients With Intermediate Risk Factors?  

Science Conference Proceedings (OSTI)

Purpose: To determine whether adjuvant chemoradiotherapy (CRT) improves the outcome of cervical cancer patients with intermediate risk factors. Methods and Materials: Between January 2000 and June 2006, the medical records of 735 patients who had undergone radical surgery for Stage IB-IIA cervical cancer were reviewed retrospectively. Of the 735 patients, 172 with two or more intermediate risk factors (i.e., lymphovascular space involvement, deep stromal invasion, and tumor size {>=}2 cm) were grouped as follows according to the adjuvant treatment received: 34 patients, no further treatment; 49 patients, RT; and 89 patients, CRT. The significance of the clinical parameters and recurrence-free survival of each group were analyzed. Results: Of the 172 patients with any of the intermediate risk factors, 137 (79.6%) had two or more intermediate risk factors. Of the 172 patients, 12 developed recurrences (6.4%)->(7.0%), with 6 in the pelvis and 6 in distant sites. All 12 recurrences occurred in those who had two or more intermediate risk factors (sensitivity, 100%); however, only six recurrences were detected in patients who met the Gynecologic Oncology Group criteria for the intermediate-risk group (sensitivity, 50%; Z test, p .05). Conclusion: Postoperative adjuvant CRT can improve the outcome of cervical cancer patients with intermediate risk factors, with low increase in toxicity.

Ryu, Sang-Young, E-mail: ryu@kcch.re.k [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Park, Sang-Il [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Nam, Byung-Ho [Center for Clinical Trials, National Cancer Center, Kyongi (Korea, Republic of); Cho, Chul-Koo [Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Kidong; Kim, Beob-Jong; Kim, Moon-Hong; Choi, Seok-Cheol; Lee, Eui-Don; Lee, Kyoung-Hee [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

2011-03-01T23:59:59.000Z

30

Ralph Holman Lifetime Achievement Award  

Science Conference Proceedings (OSTI)

Significant lifetime and meritorious achievements in areas of interest to the Health and Nutrition Division of AOCS are recognized with the Ralph Holman Lifetime Achievement Award. Ralph Holman Lifetime Achievement Award Divisions achievement agri

31

Impact of Primary Gleason Grade on Risk Stratification for Gleason Score 7 Prostate Cancers  

SciTech Connect

Purpose: To evaluate the primary Gleason grade (GG) in Gleason score (GS) 7 prostate cancers for risk of non-organ-confined disease with the goal of optimizing radiotherapy treatment option counseling. Methods: One thousand three hundred thirty-three patients with pathologic GS7 were identified in the Duke Prostate Center research database. Clinical factors including age, race, clinical stage, prostate-specific antigen at diagnosis, and pathologic stage were obtained. Data were stratified by prostate-specific antigen and clinical stage at diagnosis into adapted D'Amico risk groups. Univariate and multivariate analyses were performed evaluating for association of primary GG with pathologic outcome. Results: Nine hundred seventy-nine patients had primary GG3 and 354 had GG4. On univariate analyses, GG4 was associated with an increased risk of non-organ-confined disease. On multivariate analysis, GG4 was independently associated with seminal vesicle invasion (SVI) but not extracapsular extension. Patients with otherwise low-risk disease and primary GG3 had a very low risk of SVI (4%). Conclusions: Primary GG4 in GS7 cancers is associated with increased risk of SVI compared with primary GG3. Otherwise low-risk patients with GS 3+4 have a very low risk of SVI and may be candidates for prostate-only radiotherapy modalities.

Koontz, Bridget F., E-mail: bridget.koontz@duke.edu [Department of Radiation Oncology, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Tsivian, Matvey [Division of Urology, Department of Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Mouraviev, Vladimir [Department of Radiation Oncology, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Sun, Leon [Division of Urology, Department of Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Vujaskovic, Zeljko [Department of Radiation Oncology, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Moul, Judd [Division of Urology, Department of Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Lee, W. Robert [Department of Radiation Oncology, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States)

2012-01-01T23:59:59.000Z

32

Role of CYP1B1 in PAH-DNA Adduct Formation and Breast Cancer Risk  

NLE Websites -- All DOE Office Websites (Extended Search)

Role of CYP1B1 in PAH-DNA Adduct Formation and Breast Cancer Risk Role of CYP1B1 in PAH-DNA Adduct Formation and Breast Cancer Risk Title Role of CYP1B1 in PAH-DNA Adduct Formation and Breast Cancer Risk Publication Type Report Year of Publication 2010 Authors Goth-Goldstein, Regine, Marion L. Russell, Donghui Li, Ana P. Müller, Maira Caleffi, Joao Eschiletti, Marcia Graudenz, and Michael D. Sohn Date Published 04/2010 Publisher Lawrence Berkeley National Laboratory City Berkeley Abstract This study investigated the hypothesis that increased exposure to polycyclic aromatic hydrocarbons (PAHs) increases breast cancer risk. PAHs are products of incomplete burning of organic matter and are present in cigarette smoke, ambient air, drinking water, and diet. PAHs require metabolic transformation to bind to DNA, causing DNA adducts, which can lead to mutations and are thought to be an important pre-cancer marker. In breast tissue, PAHs appear to be metabolized to their cancer-causing form primarily by the cytochrome P450 enzyme CYP1B1. Because the genotoxic impact of PAH depends on their metabolism, we hypothesized that high CYP1B1 enzyme levels result in increased formation of PAH-DNA adducts in breast tissue, leading to increased development of breast cancer. We have investigated molecular mechanisms of the relationship between PAH exposure, CYP1B1 expression and breast cancer risk in a clinic-based case-control study. We collected histologically normal breast tissue from 56 women (43 cases and 13 controls) undergoing breast surgery and analyzed these specimens for CYP1B1 genotype, PAH-DNA adducts and CYP1B1 gene expression. We did not detect any difference in aromatic DNA adduct levels of cases and controls, only between smokers and non-smokers. CYP1B1 transcript levels were slightly lower in controls than cases, but the difference was not statistically significant. We found no correlation between the levels of CYP1B1 expression and DNA adducts. If CYP1B1 has any role in breast cancer etiology it might be through its metabolism of estrogen rather than its metabolism of PAHs. However, due to the lack of statistical power these results should be interpreted with caution

33

Analysis of cancer risk related to longitudinal information on smoking habits  

SciTech Connect

Radiation Effects Research Foundation (RERF) has followed the RERF Life Span Study (LSS) cohort consisting of atomic bomb survivors and unexposed subjects for more than 40 years. The information on their lifestyles, including smoking habits, has been collected in the past 25 years through two mail surveys of the entire LSS cohort and three interview surveys of a subcohort for the biennial medical examination program. In the present study an attempt was made to consolidate the information on smoking habits obtained from the five serial surveys, and then a risk analysis was conducted to evaluate the effect of updating the smoking information on the smoking-related risk estimates for lung cancer. The estimates of smoking-related risk became larger and estimates of dose response became sharper by updating smoking information using all of the data obtained from the five serial surveys. Analyses were also conducted for cancer sites other than lung. The differences in risk estimates between the two approaches were not as evident for the other cancer sites as for lung. 13 refs., 2 figs., 6 tabs.

Akiba, Suminori [Radiation Effects Research Foundation, Hiroshima (Japan)

1994-11-01T23:59:59.000Z

34

Percentage of Positive Biopsy Cores: A Better Risk Stratification Model for Prostate Cancer?  

Science Conference Proceedings (OSTI)

Purpose: To assess the prognostic value of the percentage of positive biopsy cores (PPC) and perineural invasion in predicting the clinical outcomes after radiotherapy (RT) for prostate cancer and to explore the possibilities to improve on existing risk-stratification models. Methods and Materials: Between 1993 and 2004, 1,056 patients with clinical Stage T1c-T3N0M0 prostate cancer, who had four or more biopsy cores sampled and complete biopsy core data available, were treated with external beam RT, with or without a high-dose-rate brachytherapy boost at William Beaumont Hospital. The median follow-up was 7.6 years. Multivariate Cox regression analysis was performed with PPC, Gleason score, pretreatment prostate-specific antigen, T stage, PNI, radiation dose, androgen deprivation, age, prostate-specific antigen frequency, and follow-up duration. A new risk stratification (PPC classification) was empirically devised to incorporate PPC and replace the T stage. Results: On multivariate Cox regression analysis, the PPC was an independent predictor of distant metastasis, cause-specific survival, and overall survival (all p 50% was associated with significantly greater distant metastasis (hazard ratio, 4.01; 95% confidence interval, 1.86-8.61), and its independent predictive value remained significant with or without androgen deprivation therapy (all p 50%) with National Comprehensive Cancer Network risk stratification demonstrated added prognostic value of distant metastasis for the intermediate-risk (hazard ratio, 5.44; 95% confidence interval, 1.78-16.6) and high-risk (hazard ratio, 4.39; 95% confidence interval, 1.70-11.3) groups, regardless of the use of androgen deprivation and high-dose RT (all p < .05). The proposed PPC classification appears to provide improved stratification of the clinical outcomes relative to the National Comprehensive Cancer Network classification. Conclusions: The PPC is an independent and powerful predictor of clinical outcomes of prostate cancer after RT. A risk model replacing T stage with the PPC to reduce subjectivity demonstrated potentially improved stratification.

Huang Jiayi; Vicini, Frank A. [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Williams, Scott G. [Peter Maccallum Cancer Centre and University of Melbourne, Melbourne, Victoria (Australia); Ye Hong; McGrath, Samuel; Ghilezan, Mihai; Krauss, Daniel; Martinez, Alvaro A. [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Kestin, Larry L., E-mail: lkestin@comcast.net [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States)

2012-07-15T23:59:59.000Z

35

Fundamentals of Semantic Web Technologies in Medical Environments: a case in breast cancer risk estimation  

E-Print Network (OSTI)

Risk estimation of developing breast cancer poses as the first prevention method for early diagnosis. Furthermore, data integration from different departments involved in the process plays a key role. In order to guarantee patient safety, the whole process should be orchestrated and monitored automatically. Support for the solution will be a linked data cloud, composed by all the departments that take part in the process, combined with rule engines.

Huerga, Iker; Gerrikagoitia, Jon Kepa

2010-01-01T23:59:59.000Z

36

Assessing Cancer Risk of Coal-Fired Power Plant Workers Exposed to PAHs  

Science Conference Proceedings (OSTI)

To study the relationship between the concentration of urinary 1-OH-Py, 3-OH-BaP and the degree as well as the pathways of human exposure to PAHs, we collected 24-hour air, dietary and urine samples of 60 oven workers in a coal-fired power plant of Central ... Keywords: biomarkers, medium-air and food, polycyclic aromatic hydrocarbons (PAHs), exposure assessment, cancer risk

Bin Li; Zhaolong Zhang; Haitao Fan; Cheng Zeng

2012-05-01T23:59:59.000Z

37

Dietary Fats and Risk of Chronic DiseaseChapter 2 Omega-3 Polyunsaturated Fatty Acids And Cancer Cachexia  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 2 Omega-3 Polyunsaturated Fatty Acids And Cancer Cachexia Health Nutrition Biochemistry Omega 3 eChapters Health - Nutrition - Biochemistry Press Downloadable pdf ...

38

B Lifetimes and Mixing  

SciTech Connect

The Tevatron experiments, CDF and D0, have produced a wealth of new B-physics results since the start of Run II in 2001. We've observed new B-hadrons, seen new effects, and increased many-fold the precision with which we know the properties of b-quark systems. In these proceedings, we will discuss two of the most fruitful areas in the Tevatron B-physics program: lifetimes and mixing. We'll examine the experimental issues driving these analyses, present a summary of the latest results, and discuss prospects for the future.

Evans, Harold G.; /Indiana U.

2009-05-01T23:59:59.000Z

39

Thyroid cancer in the Marshallese: relative risk of short-lived internal emitters and external radiation exposure  

Science Conference Proceedings (OSTI)

In a study of the comparative effects of internal versus external irradiation of the thyroid in young people, we determined that the dose from internal irradiation of the thyroid with short-lived internal emitters produced several times less thyroid cancer than did the same dose of radiation given externally. We determined this finding for a group of 85 Marshall Islands children, who were less than 10 years of age at the time of exposure and who were accidentially exposed to internal and external thyroid radiation at an average level of 1400 rad. The external risk coefficient ranged between 2.5 and 4.9 cancers per million person-rad-years at risk, and thus, from our computations, the internal risk coefficient for the Marshallese children was estimated to range between 1.0 and 1.4 cancers per million person-rad-years at risk. In contrast, for individual more than 10 years of age at the time of exposure, the dose from internal irradiation of the thyroid with short-lived internal emitters produced several times more thyroid cancer than did the same dose of radiation given externally. The external risk coefficients for the older age groups were reported in the literature to be in the range of 1.0 to 3.3 cancers per million person-rad-years-at risk. We computed internal risk coefficients of 3.3 to 8.1 cancers per million person-rad-years at risk for adolescent and adult groups. This higher sensitivity to cancer induction in the exposed adolescents and adults, is different from that seen in other exposed groups. 14 refs., 8 tabs.

Lessard, E.T.; Brill, A.B.; Adams, W.H.

1985-01-01T23:59:59.000Z

40

Uncertainties in Cancer Risk Coefficients for Environmental Exposure to Radionuclides. An Uncertainty Analysis for Risk Coefficients Reported in Federal Guidance Report No. 13  

Science Conference Proceedings (OSTI)

Federal Guidance Report No. 13 (FGR 13) provides risk coefficients for estimation of the risk of cancer due to low-level exposure to each of more than 800 radionuclides. Uncertainties in risk coefficients were quantified in FGR 13 for 33 cases (exposure to each of 11 radionuclides by each of three exposure pathways) on the basis of sensitivity analyses in which various combinations of plausible biokinetic, dosimetric, and radiation risk models were used to generate alternative risk coefficients. The present report updates the uncertainty analysis in FGR 13 for the cases of inhalation and ingestion of radionuclides and expands the analysis to all radionuclides addressed in that report. The analysis indicates that most risk coefficients for inhalation or ingestion of radionuclides are determined within a factor of 5 or less by current information. That is, application of alternate plausible biokinetic and dosimetric models and radiation risk models (based on the linear, no-threshold hypothesis with an adjustment for the dose and dose rate effectiveness factor) is unlikely to change these coefficients by more than a factor of 5. In this analysis the assessed uncertainty in the radiation risk model was found to be the main determinant of the uncertainty category for most risk coefficients, but conclusions concerning the relative contributions of risk and dose models to the total uncertainty in a risk coefficient may depend strongly on the method of assessing uncertainties in the risk model.

Pawel, David [U.S. Environmental Protection Agency; Leggett, Richard Wayne [ORNL; Eckerman, Keith F [ORNL; Nelson, Christopher [U.S. Environmental Protection Agency

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
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41

Reproductive Status at First Diagnosis Influences Risk of Radiation-Induced Second Primary Contralateral Breast Cancer in the WECARE Study  

Science Conference Proceedings (OSTI)

Purpose: Our study examined whether reproductive and hormonal factors before, at the time of, or after radiation treatment for a first primary breast cancer modify the risk of radiation-induced second primary breast cancer. Methods and Materials: The Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study is a multicenter, population-based study of 708 women (cases) with asynchronous contralateral breast cancer (CBC) and 1399 women (controls) with unilateral breast cancer. Radiotherapy (RT) records, coupled with anthropomorphic phantom simulations, were used to estimate quadrant-specific radiation dose to the contralateral breast for each patient. Rate ratios (RR) and 95% confidence intervals (CI) were computed to assess the relationship between reproductive factors and risk of CBC. Results: Women who were nulliparous at diagnosis and exposed to {>=}1 Gy to the contralateral breast had a greater risk for CBC than did matched unexposed nulliparous women (RR = 2.2; 95% CI, 1.2-4.0). No increased risk was seen in RT-exposed parous women (RR = 1.1; 95% CI, 0.8-1.4). Women treated with RT who later became pregnant (8 cases and 9 controls) had a greater risk for CBC (RR = 6.0; 95% CI, 1.3-28.4) than unexposed women (4 cases and 7 controls) who also became pregnant. The association of radiation with risk of CBC did not vary by number of pregnancies, history of breastfeeding, or menopausal status at the time of first breast cancer diagnosis. Conclusion: Nulliparous women treated with RT were at an increased risk for CBC. Although based on small numbers, women who become pregnant after first diagnosis also seem to be at an increased risk for radiation-induced CBC.

Brooks, Jennifer D., E-mail: brooksj@mskcc.org [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Boice, John D. [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States)] [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Reiner, Anne S. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Bernstein, Leslie [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States)] [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States); John, Esther M. [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States)] [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, IA (United States)] [Department of Epidemiology, University of Iowa, Iowa City, IA (United States); Mellemkjaer, Lene [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark)] [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark); Knight, Julia A. [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada)] [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada); Thomas, Duncan C.; Haile, Robert W. [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States)] [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Capanu, Marinela; Bernstein, Jonine L. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Shore, Roy E. [Department of Environmental Medicine, New York University, New York, NY (United States) [Department of Environmental Medicine, New York University, New York, NY (United States); Radiation Effects Research Foundation, Hiroshima (Japan)

2012-11-15T23:59:59.000Z

42

Patient-specific radiation dose and cancer risk estimation in CT: Part II. Application to patients  

SciTech Connect

Purpose: Current methods for estimating and reporting radiation dose from CT examinations are largely patient-generic; the body size and hence dose variation from patient to patient is not reflected. Furthermore, the current protocol designs rely on dose as a surrogate for the risk of cancer incidence, neglecting the strong dependence of risk on age and gender. The purpose of this study was to develop a method for estimating patient-specific radiation dose and cancer risk from CT examinations. Methods: The study included two patients (a 5-week-old female patient and a 12-year-old male patient), who underwent 64-slice CT examinations (LightSpeed VCT, GE Healthcare) of the chest, abdomen, and pelvis at our institution in 2006. For each patient, a nonuniform rational B-spine (NURBS) based full-body computer model was created based on the patient's clinical CT data. Large organs and structures inside the image volume were individually segmented and modeled. Other organs were created by transforming an existing adult male or female full-body computer model (developed from visible human data) to match the framework defined by the segmented organs, referencing the organ volume and anthropometry data in ICRP Publication 89. A Monte Carlo program previously developed and validated for dose simulation on the LightSpeed VCT scanner was used to estimate patient-specific organ dose, from which effective dose and risks of cancer incidence were derived. Patient-specific organ dose and effective dose were compared with patient-generic CT dose quantities in current clinical use: the volume-weighted CT dose index (CTDI{sub vol}) and the effective dose derived from the dose-length product (DLP). Results: The effective dose for the CT examination of the newborn patient (5.7 mSv) was higher but comparable to that for the CT examination of the teenager patient (4.9 mSv) due to the size-based clinical CT protocols at our institution, which employ lower scan techniques for smaller patients. However, the overall risk of cancer incidence attributable to the CT examination was much higher for the newborn (2.4 in 1000) than for the teenager (0.7 in 1000). For the two pediatric-aged patients in our study, CTDI{sub vol} underestimated dose to large organs in the scan coverage by 30%-48%. The effective dose derived from DLP using published conversion coefficients differed from that calculated using patient-specific organ dose values by -57% to 13%, when the tissue weighting factors of ICRP 60 were used, and by -63% to 28%, when the tissue weighting factors of ICRP 103 were used. Conclusions: It is possible to estimate patient-specific radiation dose and cancer risk from CT examinations by combining a validated Monte Carlo program with patient-specific anatomical models that are derived from the patients' clinical CT data and supplemented by transformed models of reference adults. With the construction of a large library of patient-specific computer models encompassing patients of all ages and weight percentiles, dose and risk can be estimated for any patient prior to or after a CT examination. Such information may aid in decisions for image utilization and can further guide the design and optimization of CT technologies and scan protocols.

Li Xiang; Samei, Ehsan; Segars, W. Paul; Sturgeon, Gregory M.; Colsher, James G.; Toncheva, Greta; Yoshizumi, Terry T.; Frush, Donald P. [Medical Physics Graduate Program, Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Medical Physics Graduate Program, Department of Physics, and Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 and Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Duke Radiation Dosimetry Laboratory, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Duke Radiation Dosimetry Laboratory, Department of Radiology, Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 (United States); Division of Pediatric Radiology, Department of Radiology, Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27710 (United States)

2011-01-15T23:59:59.000Z

43

Desjarlais received Lifetime Achievement Award  

NLE Websites -- All DOE Office Websites (Extended Search)

Andr Desjarlais received a Lifetime Achievement Award from the Polyisocyanurate Insulation Manufacturers Association (PIMA) during the group's 25th Anniversary celebration...

44

Cancer risk among children of atomic bomb survivors. A review of RERF epidemiologic studies. Radiation Effects Research Foundation  

Science Conference Proceedings (OSTI)

This article summarizes recent epidemiologic studies of cancer risk among the children of atomic bomb survivors conducted at the Radiation Effects Research Foundation. These children include two groups: (1) the in utero-exposed children (ie, those born to mothers who had been pregnant at the time of the bombings of Hiroshima and Nagasaki) and (2) the F1 population, which was conceived after the atomic-bombings and born to parents of whom one or both were atomic bomb survivors. Although from 1950 to 1984 only 18 cancer cases were identified among the in utero sample, cancer risk did appear to significantly increase as maternal uterine dose increased. However, since the observed cases are too few in number to allow a site-specific review, the increased cancer risk cannot be definitively attributed to atomic bomb radiation, as yet. For those members of the F1 population who were less than 20 years old between 1946 and 1982, cancer risk did not appear to increase significantly as parental gonadal dose increased. Follow-up of this population will continue to determine if the patterns of adult-onset cancer are altered.

Yoshimoto, Y. (Radiation Effects Research Foundation, Hiroshima (Japan))

1990-08-01T23:59:59.000Z

45

Technical Considerations for NRC/National Academy Proposed Study of Cancer Risks in Populations Living near Nuclear Facilities  

Science Conference Proceedings (OSTI)

The U.S. Nuclear Regulatory Commission (NRC), through the National Academy of Sciences (NAS), is updating the 1990 U.S. National Institutes of Health - National Cancer Institute (NCI) report, "Cancer in Populations Living near Nuclear Facilities." The Electric Power Research Institute (EPRI) formed a committee of scientists and professionals in the fields of epidemiology, radiation biology, nuclear plant effluents, and environmental risk assessment to provide study design considerations to the NAS commit...

2011-06-30T23:59:59.000Z

46

Runtime verification of object lifetime specifications  

E-Print Network (OSTI)

This thesis reports on the implementation of a runtime verification system for object lifetime specifications. This system is used to explore and evaluate the expressiveness object lifetime specifications. Object lifetime ...

Benjamin, Zev (Zev A.)

2009-01-01T23:59:59.000Z

47

STOCHASTIC MODELS OF SPACE RADIATION DNA DAMAGE RESPONSES AND CANCER RISKS  

NLE Websites -- All DOE Office Websites (Extended Search)

STOCHASTIC MODELS OF SPACE RADIATION DNA DAMAGE STOCHASTIC MODELS OF SPACE RADIATION DNA DAMAGE RESPONSES AND CANCER RISKS Francis A. Cucinotta 1 , Janice M. Pluth 2 , Artem Ponomarev 3 , Shaowen Hu 3 , Jennifer Anderson 4 , Jane Harper 4 , and Peter O'Neill 4 1 NASA Lyndon B. Johnson Space Center, Houston TX, USA; 2 Lawrence Berkeley National Laboratory, Berkeley CA, USA; 3 U.S.R.A., Division of Life Sciences, Houston TX, USA; 4 MRC Radiation and Genome Stability Unit, Harwell, Didcot, UK Abstract: On space missions astronauts are exposed to a steady flux of galactic cosmic rays (GCR) consisting of high-energy protons and heavy ions. In the next decades long- term missions of up to 200 days to the Earth's moon and 1100 days to Mars are planed by NASA where cumulative doses will not be low (>100 mSv) albeit dose-

48

The Number of High-Risk Factors and the Risk of Prostate Cancer-Specific Mortality After Brachytherapy: Implications for Treatment Selection  

SciTech Connect

Purpose: To determine whether an increasing number of high-risk factors is associated with higher prostate cancer-specific mortality (PCSM) among men treated with brachytherapy (BT)-based treatment, and whether supplemental therapy has an impact on this risk. Methods and Materials: We analyzed the cases of 2234 men with localized prostate cancer treated between 1991 and 2007 with low-dose rate BT monotherapy (n = 457) or BT with supplemental external-beam radiotherapy (EBRT, n = 229), androgen suppression therapy (AST, n = 424), or both (n = 1124). All men had at least one high-risk factor (prostate-specific antigen >20 ng/mL, biopsy Gleason score 8-10, or clinical stage {>=}T2c). Competing-risks multivariable regressions were performed to determine whether the presence of at least two high-risk factors was associated with an increased risk of PCSM, with adjustment for age, comorbidity, and the type of supplemental treatment. Results: The median follow-up time was 4.3 years. The number of men with at least two high-risk factors was highest in the group treated with BT, EBRT, and AST (21%), followed by BT plus EBRT or AST (13%), and BT alone (8%) (p{sub trend} < 0.001). The adjusted hazard ratio (AHR) for PCSM for those with at least two high-risk factors (as compared with one) was 4.8 (95% confidence interval [CI], 2.8-8.0; p < 0.001). The use of both supplemental EBRT and AST was associated with a decreased risk of PCSM (AHR 0.5; 95% CI, 0.2-0.9; p = 0.03) compared with BT alone. When the high-risk factors were analyzed separately, Gleason score 8-10 was most significantly associated with increased PCSM (AHR 6.2; 95% CI, 3.5-11.2; p < 0.001). Conclusions: Men with high-risk prostate adenocarcinoma treated with BT have decreased PCSM if they receive trimodailty therapy that includes EBRT and AST. This benefit is likely most important in men with multiple determinants of high risk.

Wattson, Daniel A., E-mail: dwattson@partners.org [Harvard Radiation Oncology Program, Boston, MA (United States); Chen Minghui [Department of Statistics, University of Connecticut, Storrs, CT (United States); Moul, Judd W. [Division of Urology, Department of Surgery and Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Moran, Brian J. [Prostate Cancer Foundation of Chicago, Westmont, IL (United States); Dosoretz, Daniel E. [21st Century Oncology, Fort Myers, FL (United States); Robertson, Cary N.; Polascik, Thomas J. [Division of Urology, Department of Surgery and Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Braccioforte, Michelle H. [Prostate Cancer Foundation of Chicago, Westmont, IL (United States); Salenius, Sharon A. [21st Century Oncology, Fort Myers, FL (United States); D'Amico, Anthony V. [Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA (United States)

2012-04-01T23:59:59.000Z

49

Establishment of a bioassay system for cancer risk assessment in energy technology  

SciTech Connect

Separate abstracts were prepared for 20 papers in this report. For several years the Department of Energy (DOE), Office of Health and Environmental Research (OHER), has supported a research program aimed at developing new experimental approaches for the improvement of cancer risk assessments. The central issue is to overcome the organizational, species and other barriers that make it difficult to extrapolate laboratory-based data to predict risk to man. Most of the participants at the meeting are involved in research aimed at understanding the mechanism(s) of chemical carcinogenesis. Complex mixtures of chemicals are associated with many energy technologies. DOE's initial program emphasis focused on semi-applied research aimed at quantitative evaluation of carcinogenic activity of complex materials. Since much progress has been made in DOE integrated technology-specific chemical-biological characterization studies, the number and kinds of chemicals of concern has been reduced to a relatively few well-defined classes. Although the classes of compounds seem to be unique to some of the synfuel technologies, they are quite similar to compounds of general interest, for example, poly-nuclear aromatic hydrocarbons. Special emphasis was placed on molecular and cellular dosimetry as one of the key requirements for quantitative comparison of effects at the cell level in vivo and in vitro. Although it is relatively easy to measure cell, tissue, organ and whole organism doses associated with radiation exposures, we are just learning how to do this for chemical agents. Several methods have been developed in the past several years which can be used.

Ts'o, P.O.P.; Bruce, S.A.; Brown, A. (eds.)

1983-09-01T23:59:59.000Z

50

Reference computations of public dose and cancer risk from airborne releases of plutonium. Nuclear safety technical report  

Science Conference Proceedings (OSTI)

This report presents results of computations of doses and the associated health risks of postulated accidental atmospheric releases from the Rocky Flats Plant (RFP) of one gram of weapons-grade plutonium in a form that is respirable. These computations are intended to be reference computations that can be used to evaluate a variety of accident scenarios by scaling the dose and health risk results presented here according to the amount of plutonium postulated to be released, instead of repeating the computations for each scenario. The MACCS2 code has been used as the basis of these computations. The basis and capabilities of MACCS2 are summarized, the parameters used in the evaluations are discussed, and results are presented for the doses and health risks to the public, both the Maximum Offsite Individual (a maximally exposed individual at or beyond the plant boundaries) and the population within 50 miles of RFP. A number of different weather scenarios are evaluated, including constant weather conditions and observed weather for 1990, 1991, and 1992. The isotopic mix of weapons-grade plutonium will change as it ages, the {sup 241}Pu decaying into {sup 241}Am. The {sup 241}Am reaches a peak concentration after about 72 years. The doses to the bone surface, liver, and whole body will increase slightly but the dose to the lungs will decrease slightly. The overall cancer risk will show almost no change over this period. This change in cancer risk is much smaller than the year-to-year variations in cancer risk due to weather. Finally, x/Q values are also presented for other applications, such as for hazardous chemical releases. These include the x/Q values for the MOI, for a collocated worker at 100 meters downwind of an accident site, and the x/Q value integrated over the population out to 50 miles.

Peterson, V.L.

1993-12-23T23:59:59.000Z

51

High-Dose-Rate Brachytherapy as a Monotherapy for Favorable-Risk Prostate Cancer: A Phase II Trial  

Science Conference Proceedings (OSTI)

Purpose: There are multiple treatment options for favorable-risk prostate cancer. High-dose-rate (HDR) brachytherapy as a monotherapy is appealing, but its use is still investigational. A Phase II trial was undertaken to explore the value of such treatment in low-to-intermediate risk prostate cancer. Methods and Materials: This was a single-institution, prospective study. Eligible patients had low-risk prostate cancer features but also Gleason scores of 7 (51% of patients) and stage T2b to T2c cancer. Treatment with HDR brachytherapy with a single implant was administered over 2 days. One of four fractionation schedules was used in a dose escalation study design: 3 fractions of 10, 10.5, 11, or 11.5 Gy. Patients were assessed with the Common Terminology Criteria for Adverse Events version 2.0 for urinary toxicity, the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer scoring schema for rectal toxicity, and the Expanded Prostate Cancer Index Composite (EPIC) questionnaire to measure patient-reported health-related quality of life. Biochemical failure was defined as a prostate-specific antigen (PSA) nadir plus 2 ng/ml. Results: Between 2003 and 2008, 79 patients were enrolled. With a median follow-up of 39.5 months, biochemical relapse occurred in 7 patients. Three- and 5-year actuarial biochemical control rates were 88.4% (95% confidence interval [CI], 78.0-96.2%) and 85.1% (95% CI, 72.5-94.5%), respectively. Acute grade 3 urinary toxicity was seen in only 1 patient. There was no instance of acute grade 3 rectal toxicity. Rates of late grade 3 rectal toxicity, dysuria, hematuria, urinary retention, and urinary incontinence were 0%, 10.3%, 1.3%, 9.0%, and 0%, respectively. No grade 4 or greater toxicity was recorded. Among the four (urinary, bowel, sexual, and hormonal) domains assessed with the EPIC questionnaire, only the sexual domain did not recover with time. Conclusions: HDR brachytherapy as a monotherapy for favorable-risk prostate cancer, administered using a single implant over 2 days, is feasible and has acceptable acute and late toxicities. Further follow-up is still required to better evaluate the efficacy of such treatment.

Barkati, Maroie [Division of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne (Australia); Williams, Scott G., E-mail: scott.williams@petermac.org [Division of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne (Australia); Department of Pathology, University of Melbourne, Melbourne (Australia); Foroudi, Farshad; Tai, Keen Hun; Chander, Sarat [Division of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne (Australia); Department of Pathology, University of Melbourne, Melbourne (Australia); Dyk, Sylvia van [Division of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne (Australia); See, Andrew [Ballarat Austin Radiation Oncology Centre, Ballarat (Australia); Duchesne, Gillian M. [Division of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne (Australia); Department of Pathology, University of Melbourne, Melbourne (Australia)

2012-04-01T23:59:59.000Z

52

Dietary Fats and Risk of Chronic DiseaseChapter 4 A Clinically Relevant Lipid Model for South African Patients with Laryngeal Cancer  

Science Conference Proceedings (OSTI)

Dietary Fats and Risk of Chronic Disease Chapter 4 A Clinically Relevant Lipid Model for South African Patients with Laryngeal Cancer Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downlo

53

Environmental health-risk assessment for tritium releases at the National Tritium Labeling Facility at Lawrence Berkeley National Laboratory  

Science Conference Proceedings (OSTI)

This risk assessment calculates the probability of experiencing health effects, including cancer incidence due to tritium exposure for three groups of people: (1) LBNL workers near the LBNL facility--Building 75--that uses tritium; (2) other workers at LBNL and nearby neighbors; and (3) people who use the UC Berkeley campus area, and some Berkeley residents. All of these groups share the same probability of health effects from the background radiation from natural sources in the Berkeley area environment, including an increased risk of developing a cancer of 11,000 chances per million. In calculating risk the authors assumed continuous operation in Building 75 for at least a human lifetime. Under this assumption, LBNL workers located near Building 75 have an additional risk of 60 chances out of one million to suffer a cancer; other workers at LBNL and people who live near LBNL have an additional risk of six chances out of one million over a lifetime of exposure; and users of the UC Berkeley campus area and other residents of Berkeley have an additional risk of less than once chance out of one million over a lifetime.

McKone, T.E.; Brand, K.P. [Lawrence Livermore National Lab., CA (United States). Health and Ecological Assessment Div.; Shan, C. [Lawrence Berkeley National Lab., CA (United States). Earth Sciences Div.

1997-04-01T23:59:59.000Z

54

Quantum Dot Fluorescence Lifetime Engineering with DNA ...  

Science Conference Proceedings (OSTI)

Quantum Dot Fluorescence Lifetime Engineering with DNA Origami ... such as metal nanoparticles and semiconductor quantum dots – is challenging ...

55

High-Dose Radiotherapy With or Without Androgen Deprivation Therapy for Intermediate-Risk Prostate Cancer: Cancer Control and Toxicity Outcomes  

SciTech Connect

Purpose: To evaluate the impact of short-course androgen deprivation therapy (ADT) on cancer control outcomes and toxicity in intermediate-risk prostate cancer treated with dose-escalated external beam radiotherapy (high-dose radiotherapy [HDRT]). Methods and Materials: Demographic, disease, and treatment characteristics of prostate cancer patients at 2 institution consortiums were charted. Of 296 men with intermediate-risk prostate cancer (defined as {>=}T2b, prostate-specific antigen level >10 ng/mL, or Gleason score [GS] of 7, with none of the following: {>=}T3, prostate-specific antigen level >20 ng/mL, GS {>=}8, or positive nodes) treated with HDRT to a dose of 72 Gy or greater, 123 received short-course ADT and 173 did not. Univariate and multivariate analyses on biochemical failure-free survival (BFFS) (including subset analysis by disease factors) and on overall survival (OS) were performed, as were comparisons of gastrointestinal (GI) and genitourinary (GU) toxicity rates. Results: For the whole group, the median dose was 75.6 Gy; the minimum follow-up was 2 years, and the median follow-up was 47.4 months. For ADT vs. no ADT, the 5-year BFFS rate was 86% vs. 79% (p = 0.138) and the 5-year OS rate was 87% vs. 80% (p = 0.159). On multivariate analysis, percent positive cores (PPC) (p = 0.002) and GS (p = 0.008) were significantly associated with BFFS, with ADT showing a trend (p = 0.055). The impact of ADT was highest in the subsets with PPC greater than 50% (p = 0.019), GS 4+3 (p = 0.078), and number of risk factors greater than 1 (p = 0.022). Only intensity-modulated radiotherapy use (p = 0.012) and GS (p = 0.023) reached significance for OS, and there were no significant differences in GU or GI toxicity. Conclusions: Although the use of ADT with HDRT did not influence BFFS, our study suggests a benefit in patients with PPC greater than 50%, GS 4+3, or multiple risk factors. No OS benefit was shown, and ADT was not associated with additional radiotherapy-related GI or GU toxicity.

Edelman, Scott [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA (United States)] [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA (United States); Liauw, Stanley L. [Department of Radiation Oncology, University of Chicago, Chicago, IL (United States)] [Department of Radiation Oncology, University of Chicago, Chicago, IL (United States); Rossi, Peter J.; Cooper, Sherrie [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA (United States)] [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA (United States); Jani, Ashesh B., E-mail: abjani@emory.edu [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA (United States)

2012-08-01T23:59:59.000Z

56

Occult Breast Cancer: Scintimammography with High-Resolution Breast-specific Gamma Camera in Women at High Risk for Breast Cancer  

SciTech Connect

To prospectively evaluate a high-resolution breast-specific gamma camera for depicting occult breast cancer in women at high risk for breast cancer but with normal mammographic and physical examination findings. MATERIALS AND METHODS: Institutional Review Board approval and informed consent were obtained. The study was HIPAA compliant. Ninety-four high-risk women (age range, 36-78 years; mean, 55 years) with normal mammographic (Breast Imaging Reporting and Data System [BI-RADS] 1 or 2) and physical examination findings were evaluated with scintimammography. After injection with 25-30 mCi (925-1110 MBq) of technetium 99m sestamibi, patients were imaged with a high-resolution small-field-of-view breast-specific gamma camera in craniocaudal and mediolateral oblique projections. Scintimammograms were prospectively classified according to focal radiotracer uptake as normal (score of 1), with no focal or diffuse uptake; benign (score of 2), with minimal patchy uptake; probably benign (score of 3), with scattered patchy uptake; probably abnormal (score of 4), with mild focal radiotracer uptake; and abnormal (score of 5), with marked focal radiotracer uptake. Mammographic breast density was categorized according to BI-RADS criteria. Patients with normal scintimammograms (scores of 1, 2, or 3) were followed up for 1 year with an annual mammogram, physical examination, and repeat scintimammography. Patients with abnormal scintimammograms (scores of 4 or 5) underwent ultrasonography (US), and those with focal hypoechoic lesions underwent biopsy. If no lesion was found during US, patients were followed up with scintimammography. Specific pathologic findings were compared with scintimammographic findings. RESULTS: Of 94 women, 78 (83%) had normal scintimammograms (score of 1, 2, or 3) at initial examination and 16 (17%) had abnormal scintimammograms (score of 4 or 5). Fourteen (88%) of the 16 patients had either benign findings at biopsy or no focal abnormality at US; in two (12%) patients, invasive carcinoma was diagnosed at US-guided biopsy (9 mm each at pathologic examination). CONCLUSION: High-resolution breast-specific scintimammography can depict small (<1-cm), mammographically occult, nonpalpable lesions in women at increased risk for breast cancer not otherwise identified at mammography or physical examination.

Rachel F. Brem; Jocelyn A. Rapelyea; , Gilat Zisman; Kevin Mohtashemi; Joyce Raub; Christine B. Teal; Stan Majewski; Benjamin L. Welch

2005-08-01T23:59:59.000Z

57

Competing-Risks Mortality After Radiotherapy vs. Observation for Localized Prostate Cancer: A Population-based Study  

SciTech Connect

Purpose: Contemporary patients with localized prostate cancer (PCa) are more frequently treated with radiotherapy. However, there are limited data on the effect of this treatment on cancer-specific mortality (CSM). Our objective was to test the relationship between radiotherapy and survival in men with localized PCa and compare it with those treated with observation. Methods: A population-based cohort identified 68,797 men with cT1-T2 PCa treated with radiotherapy or observation between the years 1992 and 2005. Propensity-score matching was used to minimize potential bias related to treatment assignment. Competing-risks analyses tested the effect of treatment type (radiotherapy vs. observation) on CSM, after accounting to other-cause mortality. All analyses were carried out within PCa risk, baseline comorbidity status, and age groups. Results: Radiotherapy was associated with more favorable 10-year CSM rates than observation in patients with high-risk PCa (8.8 vs. 14.4%, hazard ratio [HR]: 0.59, 95% confidence interval [CI]: 0.50-0.68). Conversely, the beneficial effect of radiotherapy on CSM was not evident in patients with low-intermediate risk PCa (3.7 vs. 4.1%, HR: 0.91, 95% CI: 0.80-1.04). Radiotherapy was beneficial in elderly patients (5.6 vs. 7.3%, HR: 0.70, 95% CI: 0.59-0.80). Moreover, it was associated with improved CSM rates among patients with no comorbidities (5.7 vs. 6.5%, HR: 0.81, 95% CI: 0.67-0.98), one comorbidity (4.6 vs. 6.0%, HR: 0.87, 95% CI: 0.75-0.99), and more than two comorbidities (4.2 vs. 5.0%, HR: 0.79, 95% CI: 0.65-0.96). Conclusions: Radiotherapy substantially improves CSM in patients with high-risk PCa, with little or no benefit in patients with low-/intermediate-risk PCa relative to observation. These findings must be interpreted within the context of the limitations of observational data.

Abdollah, Firas, E-mail: firas.abdollah@gmail.com [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada) [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada); Department of Urology, Vita Salute San Raffaele University, Milan (Italy); Sun, Maxine [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada)] [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada); Schmitges, Jan [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada) [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada); Martini-Clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg (Germany); Thuret, Rodolphe [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada) [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada); Department of Urology, University of Montpellier Health Centre, Montpellier (France); Tian, Zhe [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada)] [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada); Shariat, Shahrokh F. [Department of Urology, Weill Medical College of Cornell University, New York, NY (United States)] [Department of Urology, Weill Medical College of Cornell University, New York, NY (United States); Briganti, Alberto [Department of Urology, Vita Salute San Raffaele University, Milan (Italy)] [Department of Urology, Vita Salute San Raffaele University, Milan (Italy); Jeldres, Claudio; Perrotte, Paul [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada) [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada); Department of Urology, University of Montreal Health Centre, Montreal (Canada); Montorsi, Francesco [Department of Urology, Vita Salute San Raffaele University, Milan (Italy)] [Department of Urology, Vita Salute San Raffaele University, Milan (Italy); Karakiewicz, Pierre I. [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada) [Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal (Canada); Department of Urology, University of Montreal Health Centre, Montreal (Canada)

2012-09-01T23:59:59.000Z

58

PEVELOPMENT OF FLUORESCENCE LIFETIME DIAGNOSTIC  

Office of Scientific and Technical Information (OSTI)

4 4 PEVELOPMENT OF FLUORESCENCE LIFETIME DIAGNOSTIC w I Project Accomplishments Summary (Attachment I) CRADA NO. TSB-1449-97 Date: U 1 8 1 9 8 Revision: 1 A . Parties The project is a relationship between the Lawrence Livennore National Laboratoq (LLNL) and Optiphase, Inc. University of California Lawrence Livermore National Laboratory 7000 East Avenue, L-399 Livermore, CA 94550 Optiphase, h c 7652 Haskell Ave. Van Nuys, CA 91406 Technical Contact - D r . Pepe Davis (8 18)782-0997ext 1 12 B . Background Fiber-optic-based sensors are excellent candidates for detecting the presence and monitoring the levels of degradation products in stockpiled weapons. Specifically, fl uorescence-based sensors are extremely sensitive, can have high specificity for compounds of interest, and are "e~ectrically

59

Measurement of the $?$-lepton lifetime at Belle  

E-Print Network (OSTI)

The lifetime of the $\\tau$-lepton is measured using the process $e^+e^-\\rightarrow\\tau^+\\tau^-$, where both $\\tau$-leptons decay to $3\\pi\

Belle Collaboration; K. Belous; M. Shapkin; A. Sokolov; I. Adachi; H. Aihara; D. M. Asner; V. Aulchenko; A. M. Bakich; A. Bala; B. Bhuyan; A. Bobrov; A. Bondar; G. Bonvicini; A. Bozek; M. Bra?ko; T. E. Browder; D. ?ervenkov; V. Chekelian; A. Chen; B. G. Cheon; K. Chilikin; R. Chistov; K. Cho; V. Chobanova; Y. Choi; D. Cinabro; J. Dalseno; Z. Doležal; D. Dutta; S. Eidelman; D. Epifanov; H. Farhat; J. E. Fast; T. Ferber; V. Gaur; S. Ganguly; A. Garmash; R. Gillard; Y. M. Goh; B. Golob; J. Haba; T. Hara; K. Hayasaka; H. Hayashii; Y. Hoshi; W. -S. Hou; T. Iijima; K. Inami; A. Ishikawa; R. Itoh; T. Iwashita; I. Jaegle; T. Julius; E. Kato; H. Kichimi; C. Kiesling; D. Y. Kim; H. J. Kim; J. B. Kim; M. J. Kim; Y. J. Kim; K. Kinoshita; B. R. Ko; P. Kodyš; S. Korpar; P. Križan; P. Krokovny; T. Kuhr; A. Kuzmin; Y. -J. Kwon; J. S. Lange; S. -H. Lee; J. Libby; D. Liventsev; P. Lukin; D. Matvienko; H. Miyata; R. Mizuk; G. B. Mohanty; T. Mori; R. Mussa; Y. Nagasaka; E. Nakano; M. Nakao; M. Nayak; E. Nedelkovska; C. Ng; N. K. Nisar; S. Nishida; O. Nitoh; S. Ogawa; S. Okuno; S. L. Olsen; W. Ostrowicz; G. Pakhlova; C. W. Park; H. Park; H. K. Park; T. K. Pedlar; R. Pestotnik; M. Petri?; L. E. Piilonen; M. Ritter; M. Röhrken; A. Rostomyan; S. Ryu; H. Sahoo; T. Saito; Y. Sakai; S. Sandilya; D. Santel; L. Santelj; T. Sanuki; V. Savinov; O. Schneider; G. Schnell; C. Schwanda; D. Semmler; K. Senyo; O. Seon; V. Shebalin; C. P. Shen; T. -A. Shibata; J. -G. Shiu; B. Shwartz; A. Sibidanov; F. Simon; Y. -S. Sohn; S. Stani?; M. Stari?; M. Steder; T. Sumiyoshi; U. Tamponi; G. Tatishvili; Y. Teramoto; K. Trabelsi; T. Tsuboyama; M. Uchida; S. Uehara; T. Uglov; Y. Unno; S. Uno; Y. Usov; S. E. Vahsen; C. Van Hulse; P. Vanhoefer; G. Varner; K. E. Varvell; A. Vinokurova; V. Vorobyev; M. N. Wagner; C. H. Wang; P. Wang; M. Watanabe; Y. Watanabe; K. M. Williams; E. Won; J. Yamaoka; Y. Yamashita; S. Yashchenko; Y. Yook; C. Z. Yuan; Z. P. Zhang; V. Zhilich; A. Zupanc

2013-10-31T23:59:59.000Z

60

Stability and Lifetime of K-CoMoSx Mixed Alcohol Catalysts  

SciTech Connect

Researchers have studied sulfide-type catalysts for the production of mixed alcohols from synthesis gas for several decades. Despite many advances in the art, these processes are not yet commercial, due in large part to mediocre economics and the added risk associated with uncertainty in catalyst lifetime. This talk will outline some recent studies in the lifetime and stability of K-CoMoSx-type mixed alcohol catalysts. Specifically, studies of long term operation (> 3000h), sulfiding agents, simulated methanol recycle, and morphology (probed via XRD and XPS) will be discussed, with the conclusion that these materials are likely to exhibit acceptable lifetimes in continuous operation.

Hensley, J. E.; Ruddy, D.; Schaidle, J.; Ferrell, J.; Thibodeaux, J.

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Radiological Risk Assessment of Capstone Depleted Uranium Aerosols  

SciTech Connect

Assessment of the health risk from exposure to aerosols of depleted uranium (DU) is an important outcome of the Capstone aerosol studies that established exposure ranges to personnel in armored combat vehicles perforated by DU munitions. Although the radiation exposure from DU is low, there is concern that DU deposited in the body may increase cancer rates. Radiation doses to various organs of the body resulting from the inhalation of DU aerosols measured in the Capstone studies were calculated using International Commission on Radiological Protection (ICRP) models. Organs and tissues with the highest calculated committed equivalent 50-yr doses were lung and extrathoracic tissues (nose and nasal passages, pharynx, larynx, mouth and thoracic lymph nodes). Doses to the bone surface and kidney were about 5 to 10% of the doses to the extrathoracic tissues. The methodologies of the ICRP International Steering Committee on Radiation Standards (ISCORS) were used for determining the whole body cancer risk. Organ-specific risks were estimated using ICRP and U.S. Environmental Protection Agency (EPA) methodologies. Risks for crewmembers and first responders were determined for selected scenarios based on the time interval of exposure and for vehicle and armor type. The lung was the organ with the highest cancer mortality risk, accounting for about 97% of the risks summed from all organs. The highest mean lifetime risk for lung cancer for the scenario with the longest exposure time interval (2 h) was 0.42%. This risk is low compared with the natural or background risk of 7.35%. These risks can be significantly reduced by using an existing ventilation system (if operable) and by reducing personnel time in the vehicle immediately after perforation.

Hahn, Fletcher; Roszell, Laurie E.; Daxon, Eric G.; Guilmette, Ray A.; Parkhurst, MaryAnn

2009-02-26T23:59:59.000Z

62

Pelvic Nodal Radiotherapy in Patients With Unfavorable Intermediate and High-Risk Prostate Cancer: Evidence, Rationale, and Future Directions  

SciTech Connect

Over the past 15 years, there have been three major advances in the use of external beam radiotherapy in the management of men with clinically localized prostate made. They include: (1) image guided (IG) three-dimensional conformal/intensity modulated radiotherapy; (2) radiation dose escalation; and (3) androgen deprivation therapy. To date only the last of these three advances have been shown to improve overall survival. The presence of occult pelvic nodal involvement could explain the failure of increased conformality and dose escalation to prolong survival, because the men who appear to be at the greatest risk of death from clinically localized prostate cancer are those who are likely to have lymph node metastases. This review discusses the evidence for prophylactic pelvic nodal radiotherapy, including the key trials and controversies surrounding this issue.

Morikawa, Lisa K. [The University of Texas, M. D. Anderson Cancer Center (United States); Memorial Sloan-Kettering Cancer Center (United States); Roach, Mack, E-mail: mroach@radonc.ucsf.ed [University of California San Francisco (UCSF), Helen Diller Family Comprehensive Cancer Center (United States)

2011-05-01T23:59:59.000Z

63

The Mechanism of Low Dose Radiation Risk Associated with Diagnostic X-rays,  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanism of Low Dose Radiation Risk Associated with Diagnostic X-rays, Mechanism of Low Dose Radiation Risk Associated with Diagnostic X-rays, PET, and Gamma-rays Douglas Boreham McMaster University Abstract The goal of this project was to investigate low dose ionizing radiation effects associated with exposure to diagnostic computed tomography (CT) or positron emission tomography (PET) scans. Biological effects were evaluated in wild type and Trp53+/- heterozygous females, following in vivo exposure to diagnostic CT (75kVp, 200µ) or PET (18F-FDG) scans. The short term biological effects following CT or PET scans were evaluated in order to understand biological modification of mechanisms, such as DNA repair processes and apoptosis, that might alter long term cancer risk. Corresponding life-time cancer risk studies are in progress. Short-term

64

Biochemical Control With Radiotherapy Improves Overall Survival in Intermediate and High-Risk Prostate Cancer Patients Who Have an Estimated 10-Year Overall Survival of >90%  

SciTech Connect

Purpose: To identify subgroups of patients with carcinoma of the prostate treated with radical radiotherapy that have improved overall survival when disease is biochemically controlled. Methods and Materials: A cohort of 1,060 prostate cancer patients treated with radical radiotherapy was divided into nine subgroups based on National Comprehensive Cancer Network risk category and estimated 10-year overall survival (eOS 10y) derived from the age adjusted Charlson Comorbidity Index. Patients with and without biochemical control were compared with respect to overall survival. Actuarial estimates of overall survival were calculated using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazards models were used for analysis of overall survival. Results: Median follow-up was 125 months (range, 51-176 months). Only the subgroups with high or intermediate risk disease and an eOS 10y of >90% had a statistically significantly improved overall survival when prostate cancer was biochemically controlled. In all other groups, biochemical control made no significant difference to overall survival. In the subgroup with high-risk disease and eOS 10y >90%, actuarial overall survival was 86.3% (95% confidence interval [CI] 78.5%-94.1%) and 62.1% (95% CI 52.9%-71.3%) for patients with biochemical control and biochemical relapse respectively (p = 0.002). In the intermediate risk group with eOS >90%, actuarial overall survival was 95.3% (95% CI 89.0%-100%) and 79.8% (95% CI 68.0%-91.6%) for biochemically controlled and biochemically relapsed patients (p = 0.033). On multivariate analysis, National Comprehensive Cancer Network risk group (p = 0.005), biochemical control (p = 0.033) and eOS 10y (p < 0.001) were statistically significant. Conclusion: Biochemical control translates into improved overall survival in patients with high or intermediate risk disease and an estimated 10-year overall survival of >90%.

Herbert, Christopher, E-mail: cherbert@bccancer.bc.ca [Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC (Canada); Liu, Mitchell; Tyldesley, Scott; Morris, W. James [Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC (Canada); Joffres, Michel [Department of Health Sciences, Simon Fraser University, Surrey, BC (Canada); Khaira, Mandip; Kwan, Winkle [Department of Radiation Oncology, British Columbia Cancer Agency, Fraser Valley Centre, Surrey, BC (Canada); Moiseenko, Vitali [Department of Medical Physics, British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC (Canada); Pickles, Thomas [Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC (Canada)

2012-05-01T23:59:59.000Z

65

Using National Survey Data to Estimate Lifetimes of Residential...  

NLE Websites -- All DOE Office Websites (Extended Search)

National Survey Data to Estimate Lifetimes of Residential Appliances Title Using National Survey Data to Estimate Lifetimes of Residential Appliances Publication Type Journal...

66

Self-reported chemicals exposure, beliefs about disease causation, and risk of breast cancer in the Cape Cod Breast Cancer and Environment Study: a case-control study  

E-Print Network (OSTI)

2&1&0&1&6&0]. 34. Cape Cod Breast Cancer and the EnvironmentSpring Institute: Cape Cod Breast Cancer and Environmentbetween residence on Cape Cod, Massachusetts, and breast

Zota, Ami R; Aschengrau, Ann; Rudel, Ruthann A; Brody, Julia

2010-01-01T23:59:59.000Z

67

Reduction of Statistical Power Per Event Due to Upper Lifetime Cuts in Lifetime Measurements  

E-Print Network (OSTI)

A cut on the maximum lifetime in a lifetime fit not only reduces the number of events, but also, in some circumstances dramatically, decreases the statistical significance of each event. The upper impact parameter cut in the hadronic B trigger at CDF, which is due to technical limitations, has the same effect. In this note we describe and quantify the consequences of such a cut on lifetime measurements. We find that even moderate upper lifetime cuts, leaving event numbers nearly unchanged, can dramatically increase the statistical uncertainty of the fit result.

Jonas Rademacker

2005-02-25T23:59:59.000Z

68

Quality of Life After Hypofractionated Concomitant Intensity-Modulated Radiotherapy Boost for High-Risk Prostate Cancer  

SciTech Connect

Purpose: To evaluate the change in health-related quality of life (QOL) of patients with high-risk prostate cancer treated using hypofractionated radiotherapy combined with long-term androgen deprivation therapy. Methods and Materials: A prospective Phase I-II study enrolled patients with any of the following: clinical Stage T3 disease, prostate-specific antigen level {>=}20 ng/mL, or Gleason score 8-10. Radiotherapy consisted of 45 Gy (1.8 Gy per fraction) to the pelvic lymph nodes with a concomitant 22.5 Gy intensity-modulated radiotherapy boost to the prostate, for a total of 67.5 Gy (2.7 Gy per fraction) in 25 fractions over 5 weeks. Daily image guidance was performed using three gold seed fiducials. Quality of life was measured using the Expanded Prostate Cancer Index Composite (EPIC), a validated tool that assesses four primary domains (urinary, bowel, sexual, and hormonal). Results: From 2004 to 2007, 97 patients were treated. Median follow-up was 39 months. Compared with baseline, at 24 months there was no statistically significant change in the mean urinary domain score (p = 0.99), whereas there were decreases in the bowel (p < 0.01), sexual (p < 0.01), and hormonal (p < 0.01) domains. The proportion of patients reporting a clinically significant difference in EPIC urinary, bowel, sexual, and hormonal scores at 24 months was 27%, 31%, 55%, and 60%, respectively. However, moderate and severe distress related to these symptoms was minimal, with increases of only 3% and 5% in the urinary and bowel domains, respectively. Conclusions: Hypofractionated radiotherapy combined with long-term androgen deprivation therapy was well tolerated. Although there were modest rates of clinically significant patient-reported urinary and bowel toxicity, most of this caused only mild distress, and moderate and severe effects on QOL were limited. Additional follow-up is ongoing to characterize long-term QOL.

Quon, Harvey [Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON (Canada); Department of Radiation Oncology, University of Toronto, Toronto, ON (Canada); Cheung, Patrick C.F., E-mail: patrick.cheung@sunnybrook.ca [Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON (Canada); Department of Radiation Oncology, University of Toronto, Toronto, ON (Canada); Loblaw, D. Andrew; Morton, Gerard; Pang, Geordi; Szumacher, Ewa; Danjoux, Cyril [Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON (Canada); Department of Radiation Oncology, University of Toronto, Toronto, ON (Canada); Choo, Richard [Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States); Kiss, Alex; Mamedov, Alexandre; Deabreu, Andrea [Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON (Canada)

2012-06-01T23:59:59.000Z

69

Ionizing radiation risks to satellite power systems (SPS) workers  

DOE Green Energy (OSTI)

The radiation risks to the health of workers who will construct and maintain solar power satellites in the space environment were examined. For ionizing radiation, the major concern will be late or delayed health effects, particularly the increased risk of radiation-induced cancer. The estimated lifetime risk for cancer is 0.8 to 5.0 excess deaths per 10,000 workers per rad of exposure. Thus, for example, in 10,000 workers who completed ten missions with an exposure of 40 rem per mission, 320 to 2000 additional deaths in excess of the 1640 deaths from normally occurring cancer, would be expected. These estimates would indicate a 20 to 120% increase in cancer deaths in the worker-population. The wide range in these estimates stems from the choice of the risk-projection model and the dose-response relationsip. The choice between a linear and a linear-quadratic dose-response model may alter the risk estimate by a factor of about two. The method of analysis (e.g., relative vs absolute risk model) can alter the risk estimate by an additional factor of three. Choosing different age and sex distributions can further change the estimate by another factor of up to three. The potential genetic consequences could be of significance, but at the present time, sufficient information on the age and sex distribution of the worker population is lacking for precise estimation of risk. The potential teratogenic consequences resulting from radiation are considered significant. Radiation exposure of a pregnant worker could result in developmental abnormalities.

Lyman, J.T.; Ainsworth, E.J.; Alpen, E.L.; Bond, V.; Curtis, S.B.; Fry, R.J.M.; Jackson, K.L.; Nachtwey, S.; Sondhaus, C.; Tobias, C.A.; Fabrikant, J.I.

1980-11-01T23:59:59.000Z

70

Quantification of Contralateral Breast Dose and Risk Estimate of Radiation-Induced Contralateral Breast Cancer Among Young Women Using Tangential Fields and Different Modes of Breathing  

SciTech Connect

Purpose: Whole breast irradiation with deep-inspiration breath-hold (DIBH) technique among left-sided breast cancer patients significantly reduces cardiac irradiation; however, a potential disadvantage is increased incidental irradiation of the contralateral breast. Methods and Materials: Contralateral breast dose (CBD) was calculated by comparing 400 treatment plans of 200 left-sided breast cancer patients whose tangential fields had been planned on gated and nongated CT data sets. Various anatomic and field parameters were analyzed for their impact on CBD. For a subgroup of patients (aged {<=}45 years) second cancer risk in the contralateral breast (CB) was modeled by applying the linear quadratic model, compound models, and compound models considering dose-volume information (DVH). Results: The mean CBD was significantly higher in DIBH with 0.69 Gy compared with 0.65 Gy in normal breathing (P=.01). The greatest impact on CBD was due to a shift of the inner field margin toward the CB in DIBH (mean 0.4 cm; range, 0-2), followed by field size in magnitude. Calculation with different risk models for CBC revealed values of excess relative risk/Gy ranging from 0.48-0.65 vs 0.46-0.61 for DIBH vs normal breathing, respectively. Conclusion: Contralateral breast dose, although within a low dose range, was mildly but significantly increased in 200 treatment plans generated under gated conditions, predominately due to a shift in the medial field margin. Risk modeling for CBC among women aged {<=}45 years also pointed to a higher risk when comparing DIBH with normal breathing. This risk, however, was substantially lower in the model considering DVH information. We think that clinical decisions should not be affected by this small increase in CBD with DIBH because DIBH is effective in reducing the dose to the heart in all patients.

Zurl, Brigitte, E-mail: brigitte.zurl@klinikum-graz.at [Department of Therapeutic Radiology and Oncology, Medical University of Graz (Austria)] [Department of Therapeutic Radiology and Oncology, Medical University of Graz (Austria); Stranzl, Heidi; Winkler, Peter; Kapp, Karin Sigrid [Department of Therapeutic Radiology and Oncology, Medical University of Graz (Austria)] [Department of Therapeutic Radiology and Oncology, Medical University of Graz (Austria)

2013-02-01T23:59:59.000Z

71

Energy-aware Gateway Selection for Increasing the Lifetime of Wireless Body Area Sensor Networks  

Science Conference Proceedings (OSTI)

A Wireless Body Area Sensor Network (WBASN) is composed of a set of sensor nodes, placed on, near or within a human body. WBASNs opt to continuously monitor the health conditions of individuals under medical risk, e.g., elders and chronically ill people, ... Keywords: Energy harvesting, Gateway selection algorithm, Network lifetime, Selective engagement of nodes, Wireless Body Area Sensor Networks (WBASN)

Cuneyt Bayilmis; Mohamed Younis

2012-06-01T23:59:59.000Z

72

Martzloff Cited for Lifetime Achievement by IEEE Standards ...  

Science Conference Proceedings (OSTI)

Martzloff Cited for Lifetime Achievement by IEEE Standards Association. From NIST Tech Beat: December 12, 2012. ...

2013-05-21T23:59:59.000Z

73

PSA Response to Neoadjuvant Androgen Deprivation Therapy Is a Strong Independent Predictor of Survival in High-Risk Prostate Cancer in the Dose-Escalated Radiation Therapy Era  

SciTech Connect

Purpose: The aim of the study was to evaluate the prognostic value of prostate-specific antigen (PSA) response to neoadjuvant androgen deprivation therapy (ADT) prior to dose-escalated radiation therapy (RT) and long-term ADT in high-risk prostate cancer. Methods and Materials: We reviewed the charts of all patients diagnosed with high-risk prostate cancer and treated with a combination of long-term ADT (median, 24 months) and dose-escalated (median, 75.6 Gy) RT between 1990 and 2007. The associations among patient, tumor, and treatment characteristics with biochemical response to neoadjuvant ADT and their effects on failure-free survival (FFS), time to distant metastasis (TDM), prostate cancer-specific mortality (PCSM) and overall survival (OS) were examined. Results: A total of 196 patients met criteria for inclusion. Median follow-up time for patients alive at last contact was 7.0 years (range, 0.5-18.1 years). Multivariate analysis identified the pre-RT PSA concentration (<0.5 vs {>=}0.5 ng/mL) as a significant independent predictor of FFS (P=.021), TDM (P=.009), PCSM (P=.039), and OS (P=.037). On multivariate analysis, pretreatment PSA (iPSA) and African-American race were significantly associated with failure to achieve a pre-RT PSA of <0.5 ng/mL. Conclusions: For high-risk prostate cancer patients treated with long-term ADT and dose-escalated RT, a pre-RT PSA level {>=}0.5 ng/mL after neoadjuvant ADT predicts for worse survival measures. Both elevated iPSA and African-American race are associated with increased risk of having a pre-RT PSA level {>=}0.5 ng/mL. These patients should be considered for clinical trials that test newer, more potent androgen-depleting therapies such as abiraterone and MDV3100 in combination with radiation.

McGuire, Sean E., E-mail: semcguir@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States); Lee, Andrew K. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cerne, Jasmina Z. [Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States)] [Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States); Munsell, Mark F. [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Levy, Lawrence B. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kudchadker, Rajat J. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Choi, Seungtaek L.; Nguyen, Quynh N.; Hoffman, Karen E.; Pugh, Thomas J.; Frank, Steven J. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Corn, Paul G.; Logothetis, Christopher J. [Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kuban, Deborah A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2013-01-01T23:59:59.000Z

74

Mixing and Lifetimes of b-hadrons  

Science Conference Proceedings (OSTI)

We review the status of mixing and lifetimes of b-hadrons. We will show that {delta}{gamma}/{delta}M, a{sub sl} and {phi} are better suited to search for new physics effects than {delta}M alone, because of our poor knowledge of the decay constants. The theoretical precision in the determination of {gamma}{sub 12}/M{sub 12}--which contains all information on {delta}{gamma}/{delta}M, a{sub sl} and {phi}--can be tested directly by investigating the lifetimes of b-hadrons, because both quantities rely on the same theoretical footing. In particular we will also present a numerical estimate for the lifetime of the {xi}{sub b}-baryon.

Lenz, Alexander J. [Fakultaet fuer Physik, Universitaet Regensburg, 93040 Regensburg (Germany)

2008-07-02T23:59:59.000Z

75

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary glandas a means of understanding human risk for breast cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

susceptibility to low-dose ionizing radiation in the mouse mammary gland susceptibility to low-dose ionizing radiation in the mouse mammary gland as a means of understanding human risk for breast cancer Antoine M. Snijders 1 , Francesco Marchetti 1 , Ju Han 1 , Sandhya Bhatnagar 1 , Nadire Duru 1 , Zhi Hu 1 , Jian-Hua Mao 1 , Mina Bissell 1 , Joe Gray 1,2 , Gary H. Karpen 1 , Priscilla K. Cooper 1 and Andrew J. Wyrobek 1 1 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 2 Current affiliation: Biomedical Engineering, Oregon Health Science Univ, Portland, OR Goal: Our goal is to develop an in vivo mechanistic model of genetic variation in the low-dose damage responses of mammary glands using inbred mice known to vary in their sensitivity to low-dose induced mammary gland cancer, and to develop molecular predictors for susceptibility or resistance to low-dose induced breast cancer.

76

Prompt Neutron Lifetime for the NBSR Reactor  

SciTech Connect

In preparation for the proposed conversion of the National Institute of Standards and Technology (NIST) research reactor (NBSR) from high-enriched uranium (HEU) to low-enriched uranium (LEU) fuel, certain point kinetics parameters must be calculated. We report here values of the prompt neutron lifetime that have been calculated using three independent methods. All three sets of calculations demonstrate that the prompt neutron lifetime is shorter for the LEU fuel when compared to the HEU fuel and longer for the equilibrium end-of-cycle (EOC) condition when compared to the equilibrium startup (SU) condition for both the HEU and LEU fuels.

Hanson, A.L.; Diamond, D.

2012-06-24T23:59:59.000Z

77

USING RISK-BASED CORRECTIVE ACTION (RBCA) TO ASSESS (THEORETICAL) CANCER DEATHS AVERTED COMPARED TO THE (REAL) COST OF ENVIRONMENTAL REMEDIATION  

SciTech Connect

In 1978, on the basis of existing health studies at the time, the Uranium Mill Tailings Remedial Action (UMTRA) Project legislation was proposed that would authorize remedial action at inactive uranium processing sites and vicinity properties. The cost of the program to the Federal Government was expected to be $180 million. With the completion of this project, approximately 1300 theoretical cancer deaths were prevented in the next 100 years at a cost of $1.45 billion, based on the Fiscal Year 1998 Federal UMTRA budget. The individual site costs ranged from $0.2 million up to $18 billion spent per theoretical cancer death averted over the next 100 years. Resources required to sustain remediation activities such as this are subject to reduction over time, and are originally based on conservative assumptions that tend to overestimate risks to the general public. This evaluation used a process incorporating risk-based corrective action (RBCA); a three-tiered, decision-making process tailoring corrective action activities according to site-specific conditions and risks. If RBCA had been applied at the start of the UMTRA Project, and using a criterion of >1 excess cancer death prevented as justification to remediate the site, only 50% of the existing sites would have been remediated, yielding a cost savings of $303.6 million to the Federal Government and affected States, which share 10% of the cost. This cost savings equates to 21% of the overall project budget. In addition, only 22% of the vicinity properties had structural contamination contributing to elevated interior gamma exposure and radon levels. Focusing only on these particular properties could have saved an additional $269.3 million, yielding a total savings of $573 million; 40% of the overall project budget. As operational experience is acquired, including greater understanding of the radiological and nonradiological risks, decisions should be based on the RBCA process, rather than relying on conservative assumptions that tend to overestimate risks to the general public.

Miller, M. L.; Hylko, J. M.

2002-02-25T23:59:59.000Z

78

Materials Education: Opportunities over a Lifetime  

SciTech Connect

A report, in the form of abbreviated notes, of the 17th Biennial Conference on National Materials Policy ''Materials Education: Opportunities over a Lifetime'' held May 20-21, 2002 in College Park, MD, sponsored by the Federation of Materials Societies and the University Materials Council.

Anderson, Iver E.; Schwartz, Lyle H.; Faber, Katherine T.; Cargill III, G. Slade; Houston, Betsy

2003-10-28T23:59:59.000Z

79

Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers  

E-Print Network (OSTI)

random hexamers and oligo-dT pri- mers, according to the manufacturer’s instructions. Breast cell lines culture Breast cancer (PMC42, MCF-7 and SUM-159) and nor- mal breast (MCF-10A) cell lines were cultured as pre- viously described [29... in the Chromatin Immunoprecipitation section. Chromatin Immunoprecipitation (ChIP) ChIP experiments were performed using chromatin extracted from SUM-159 (cancer), PMC42 (cancer), MCF-7 (cancer) and MCF10-A (normal) breast cell lines with antibodies against RNA...

Maia, Ana-Teresa; Antoniou, Antonis C; O'Reilly, Martin; Samarajiwa, Shamith; Dunning, Mark; Kartsonaki, Christiana; Chin, Suet-Feung; Curtis, Christina N; McGuffog, Lesley; Domchek, Susan M; Embrace, Embrace; Easton, Douglas F; Peock, Susan; Frost, Debra; Evans, D Gareth; Eeles, Ros; Izatt, Louise; Adlard, Julian; Eccles, Diana; Gemo, Gemo; Sinilnikova, Olga M; Mazoyer, Sylvie; Stoppa-Lyonnet, Dominique; Gauthier-Villars, Marion; Faivre, Laurence; Venat-Bouvet, Laurence; Delnatte, Capucine; Nevanlinna, Heli; Couch, Fergus J; Godwin, Andrew K; Caligo, Maria-Adelaide; Swe-brca, Swe-brca; Barkardottir, Rosa B; kConFab, kConFab; Chen, Xiaoqing; Beesley, Jonathan; Healey, Sue; Caldas, Carlos; Chenevix-Trench, Georgia; Ponder, Bruce AJ

2012-04-18T23:59:59.000Z

80

Association of P53 and ATM Polymorphisms With Risk of Radiation-Induced Pneumonitis in Lung Cancer Patients Treated With Radiotherapy  

Science Conference Proceedings (OSTI)

Purpose: Radiation-induced pneumonitis (RP) is the most common dose-limiting complication in lung cancer patients treated with radiotherapy. Accumulating evidence indicates that P53 and the ataxia telangiectasia-mutated protein (ATM)-dependent signaling response cascade play a crucial role in radiation-induced diseases. Consistent with this, our previous study showed that a functional genetic ATM polymorphism was associated with increased RP risk. Methods and Materials: To evaluate the role of genetic P53 polymorphism in RP, we analyzed the P53 Arg72Pro polymorphism in a cohort including 253 lung cancer patients receiving thoracic irradiation. Results: We found that the P53 72Arg/Arg genotype was associated with increased RP risk compared with the 72Pro/Pro genotype. Furthermore, the P53 Arg72Pro and ATM -111G>A polymorphisms display an additive combination effect in intensifying the risk of developing RP. The cross-validation test showed that 63.2% of RP cases can be identified by P53 and ATM genotypes. Conclusions: These results indicate that genetic polymorphisms in the ATM-P53 pathway influence susceptibility to RP and genotyping P53 and ATM polymorphisms might help to identify patients susceptible to developing RP when receiving radiotherapy.

Yang Ming [Departments of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Key Laboratory for Carcinogenesis and Cancer Prevention, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Zhang Li [Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Bi Nan; Ji Wei [Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Tan Wen [Departments of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Key Laboratory for Carcinogenesis and Cancer Prevention, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Zhao Lujun [Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Yu Dianke; Wu Chen [Departments of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Key Laboratory for Carcinogenesis and Cancer Prevention, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Wang Luhua [Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)

2011-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
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81

Mass and Lifetime Measurements in Storage Rings  

Science Conference Proceedings (OSTI)

Masses of nuclides covering a large area of the chart of nuclides can be measured in storage rings where many ions circulate at the same time. In this paper the recent progress in the analysis of Schottky mass spectrometry data is presented as well as the technical improvements leading to higher accuracy for isochronous mass measurements with a time-of-flight detector. The high sensitivity of the Schottky method down to single ions allows to measure lifetimes of nuclides by observing mother and daughter nucleus simultaneously. In this way we investigated the decay of bare and H-like 140Pr. As we could show the lifetime can be even shortened compared to those of atomic nuclei despite of a lower number of electrons available for internal conversion or electron capture.All these techniques will be implemented with further improvements at the storage rings of the new FAIR facility at GSI in the future.

Weick, H.; Beckert, K.; Beller, P.; Bosch, F.; Dimopoulou, C.; Kozhuharov, C.; Kurcewicz, J.; Mazzocco, M.; Nociforo, C.; Nolden, F.; Steck, M.; Sun, B.; Winkler, M. [Gesellschaft fuer Schwerionenforschung mbH, 64291 Darmstadt (Germany); Brandau, C.; Chen, L.; Geissel, H.; Knoebel, R.; Litvinov, S. A.; Litvinov, Yu. A.; Scheidenberger, C. [Gesellschaft fuer Schwerionenforschung mbH, 64291 Darmstadt (Germany); II. Phys. Institut, Justus-Liebig-Universitaet Giessen, 35392 Giessen (Germany)] (and others)

2007-05-22T23:59:59.000Z

82

ICALEPCS Lifetime Achievement Award to Martin Kraimer  

NLE Websites -- All DOE Office Websites (Extended Search)

Cockroaches Advance Student's Study of Ancient Life Cockroaches Advance Student's Study of Ancient Life Bringing Fruit Flies in from the Cold DOE Environmental Sustainability Award to Three from APS 2009 Chemistry Nobel to APS Users The First Experiment at the LCLS APS News Archives: 2012 | 2011 | 2010 | 2009 2008 | 2007 | 2006 | 2005 2004 | 2003 | 2002 | 2001 2000 Subscribe to APS News rss feed ICALEPCS Lifetime Achievement Award to Martin Kraimer OCTOBER 28, 2009 Bookmark and Share Left to right: Ryotaro Tanaka (ICALEPCS2009 Chair), Jeffrey O. Hill, Martin R. Kraimer, Bob Daleisio, and In Soo Ko (ICALEPCS ISAC Chair), October 15, 2009, Kobe Japan. Martin R. Kraimer, formerly of the Controls Group in the Argonne APS Engineering Support Division, is one of three recipients of the first Lifetime Achievement Award presented by the ICALEPCS International

83

B mixing and lifetimes at the Tevatron  

SciTech Connect

The Tevatron collider at Fermilab provides a very rich environment for the study of b-hadrons. Both the D0 and CDF experiments have collected a sample of about 1 fb{sup -1}. they report results on three topics: b-hadron lifetimes, polarization amplitudes and the decay width difference in B{sub s}{sup 0} {yields} J/{psi}{phi}, and B{sub s}{sup 0} mixing.

Gomez-Ceballos, G.; /Cantabria Inst. of Phys.; Piedra, J.; /Paris U., VI-VII

2006-04-01T23:59:59.000Z

84

Dosimetric parameters as predictive factors for biochemical control in patients with higher risk prostate cancer treated with Pd-103 and supplemental beam radiation  

SciTech Connect

Purpose: To analyze the role of dosimetric quality parameters in maximizing cancer eradication in higher risk prostate cancer patients treated with palladium (Pd)-103 and supplemental beam radiation. Methods: One-hundred-seventy-nine patients treated with Pd-103 and supplemental beam radiation, with minimum 2 years follow-up prostate-specific antigen (PSA) values and posttreatment computed tomography scans were analyzed. Dosimetric parameters included the V100 (percent of the postimplant volume covered by the prescription dose), the D90 (the minimum dose that covered 90% of the post implant volume), and the treatment margins (the radial distance between the prostatic edge and the prescription isodose). Treatment margins (TMs) were calculated using premarket software. Results: Freedom from biochemical failure was 79% at 3 years, with 92 of the 179 patients (51%) followed beyond 3 years. In comparing patients who did or did not achieve biochemical control, the most striking differences were in biologic factors of pretreatment PSA and Gleason score. The V100, D90, and average TM all showed nonsignificant trends to higher values in patients with biochemical control. In multivariate analysis of each of the three dosimetric parameters against PSA and Gleason score, TM showed the strongest correlation with biochemical control (p = 0.19). Conclusions: For patients with intermediate and high-risk prostate cancer treated with Pd-103 brachytherapy and external beam radiation, biologic factors (PSA and Gleason score) were the most important determinants of cancer eradication. However, there is a trend to better outcomes among patients with higher quality implant parameters, suggesting that attention to implant quality will maximize the likelihood of cure.

Orio, Peter [Department of Radiation Oncology, University of Washington, Seattle, WA (United States); Radiation Oncology, Puget Sound Health Care System, Department of Veterans Affairs, Seattle, WA (United States); Wallner, Kent [Department of Radiation Oncology, University of Washington, Seattle, WA (United States) and Radiation Oncology, Puget Sound Health Care System, Department of Veterans Affairs, Seattle, WA (United States) and Group Health Cooperative, Seattle, WA (United States)]. E-mail: kent.Wallner@med.va.gov; Merrick, Gregory [Schiffler Cancer Center, Wheeling, WV (United States); Herstein, Andrew [Radiation Oncology, Puget Sound Health Care System, Department of Veterans Affairs, Seattle, WA (United States); Mitsuyama, Paul [Department of Radiation Oncology, University of Washington, Seattle, WA (United States); Radiation Oncology, Puget Sound Health Care System, Department of Veterans Affairs, Seattle, WA (United States); Thornton, Ken [Varian Medical Systems, Charlottesville, VA (United States); Butler, Wayne [Schiffler Cancer Center, Wheeling, WV (United States); Sutlief, Steven [Department of Radiation Oncology, University of Washington, Seattle, WA (United States); Radiation Oncology, Puget Sound Health Care System, Department of Veterans Affairs, Seattle, WA (United States)

2007-02-01T23:59:59.000Z

85

A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation  

E-Print Network (OSTI)

from Japanese atomic bomb survivors at age 70, as functionrelative risk by age at exposure in the Japanese atomic bombthe age/time dependencies suggested by Japanese atomic bomb

Shuryak, Igor; Hahnfeldt, Philip; Hlatky, Lynn; Sachs, Rainer K.; Brenner, David J.

2009-01-01T23:59:59.000Z

86

Long-Term Results After High-Dose Radiotherapy and Adjuvant Hormones in Prostate Cancer: How Curable Is High-Risk Disease?  

Science Conference Proceedings (OSTI)

Purpose: To analyze long-term outcome and prognostic factors for high-risk prostate cancer defined by National Comprehensive Cancer Network criteria treated with high-dose radiotherapy and androgen deprivation in a single institution. Methods and Materials: A total of 306 patients treated between 1995 and 2007 in a radiation dose-escalation program fulfilled the National Comprehensive Cancer Network high-risk criteria. Median International Commission on Radiation Units and Measurements radiation dose was 78 Gy (range, 66.0-84.1 Gy). Long-term androgen deprivation (LTAD) was administered in 231 patients, short-term androgen deprivation (STAD) in 59 patients, and no hormones in 16 patients. The Phoenix (nadir plus 2 ng/mL) consensus definition was used for biochemical control. Multivariate analysis was performed to determine the independent prognostic impact of clinical and treatment factors. Median follow-up time was 64 months (range, 24-171 months). Results: The actuarial overall survival at 5 and 10 years was 95.7% and 89.8%, respectively, and the corresponding biochemical disease-free survival (bDFS) was 89.5% and 67.2%, respectively. Fourteen patients (4.6%) developed distant metastasis. Multivariate analysis showed that Gleason score >7 (p = 0.001), pretreatment prostate-specific antigen (PSA) level >20 ng/mL (p = 0.037), higher radiation dose (p = 0.005), and the use of adjuvant LTAD vs. STAD (p = 0.011) were independent prognostic factors affecting bDFS in high-risk disease. The 5-year bDFS for patients treated with LTAD plus radiotherapy dose >78 Gy was 97%. Conclusions: For high-risk patients the present series showed that the use of LTAD in conjunction with higher doses (>78 Gy) of radiotherapy was associated with improved biochemical tumor control. We observed that the presence of Gleason sum >7 and pretreatment PSA level >20 ng/mL in the same patient represents a 6.8 times higher risk of PSA failure. These men could be considered for clinical trials with addition of novel agents.

Zapatero, Almudena, E-mail: azapatero.hlpr@salud.madrid.org [Department of Radiation Oncology, Hospital Universitario de la Princesa, Madrid (Spain); Garcia-Vicente, Feliciano [Department of Medical Physics, Hospital Universitario de la Princesa, Madrid (Spain); Martin de Vidales, Carmen; Cruz Conde, Alfonso; Ibanez, Yamile [Department of Radiation Oncology, Hospital Universitario de la Princesa, Madrid (Spain); Fernandez, Inmaculada; Rabadan, Mariano [Department of Urology, Hospital Universitario de la Princesa, Madrid (Spain)

2011-12-01T23:59:59.000Z

87

Measurement of Beam Lifetime and Applications for SPEAR3  

SciTech Connect

Beam lifetime studies for the SPEAR3 storage ring are presented. The three lifetime components are separated with lifetime measurements under various combinations of beam currents and fill patterns and vertical scraper scans. Touschek lifetime is studied with rf voltage scans and with the horizontal or vertical scrapers inserted. The measurements are explained with calculations based on the calibrated lattice model. Quantum lifetime measurements are performed with reduced longitudinal and horizontal apertures, respectively, from which we deduce the radiation energy loss down to a few keV per revolution and the horizontal beam size.

Huang, Xiaobiao; Corbett, Jeff; /SLAC

2011-04-05T23:59:59.000Z

88

Final report on reliability and lifetime prediction.  

Science Conference Proceedings (OSTI)

This document highlights the important results obtained from the subtask of the Goodyear CRADA devoted to better understanding reliability of tires and to developing better lifetime prediction methods. The overall objective was to establish the chemical and physical basis for the degradation of tires using standard as well as unique models and experimental techniques. Of particular interest was the potential application of our unique modulus profiling apparatus for assessing tire properties and for following tire degradation. During the course of this complex investigation, extensive relevant information was generated, including experimental results, data analyses and development of models and instruments. Detailed descriptions of the findings are included in this report.

Gillen, Kenneth Todd; Wise, Jonathan; Jones, Gary D.; Causa, Al G. [Goodyear Tire and Rubber Co., Akron, OH; Terrill, Edward R. [Goodyear Tire and Rubber Co., Akron, OH; Borowczak, Marc [Goodyear Tire and Rubber Co., Akron, OH

2012-12-01T23:59:59.000Z

89

A Phase I Trial of Samarium-153-Lexidronam Complex for Treatment of Clinically Nonmetastatic High-Risk Prostate Cancer: First Report of a Completed Study  

SciTech Connect

Purpose: We completed a Phase I trial to determine the maximum tolerated dose of samarium-153 EDTMP ({sup 153}Sm) with hormonal therapy (HT) and radiation therapy (RT) in high-risk clinically nonmetastatic prostate cancer. Methods and Materials: High-risk M0 prostate cancer patients (prostate-specific antigen >20 ng/mL, Gleason score >7, or >T3) were eligible for this prospective trial of dose-escalated radioactive {sup 153}Sm-EDTMP (.25-2.0 mCi/kg) as primary or postoperative therapy. After 1 month of HT, we administered {sup 153}Sm-EDTMP followed by 4 more months of HT, 46.8 Gy to the pelvic region and 23.4 Gy to the prostate target (TD = 70.2 Gy). The primary endpoint was Grade III toxicity or higher by the National Cancer Institute Common Toxicity Criteria. Results: Twenty-nine patients enrolled (median prostate-specific antigen = 8.2 ng/mL, 27/29 (93%) T stage {>=}T2b, 24/29 (83%) had Gleason >7) and received {sup 153}Sm-EDTMP (.25 mCi/kg, 4 patients; 0.5 mCi/kg, 4 patients; 0.75 mCi/kg, 6 patients; 1.0 mCi/kg, 6 patients; 1.5 mCi/kg, 5 patients; 2.0mCi/kg, 4 patients). Twenty-eight patients underwent all planned therapy without delays (1 patient required surgery before the start of RT). With a median follow-up time of 23 months, there were 2 patients (7 %) experiencing Grade III hematologic toxicity. There were no other Grade III or IV side effects. Conclusions: Our trial demonstrates that 2 mCi/kg {sup 153}Sm -EDTMP with HT and RT was safe and feasible in men with high-risk M0 prostate cancer. A Phase II study to test this treatment is currently underway by the Radiation Therapy Oncology Group.

Valicenti, Richard K., E-mail: richard.valicenti@ucdmc.ucdavis.ed [Department Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Trabulsi, Edouard [Department of Urology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States); Intenzo, Charles [Department of Radiology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States); Lavarino, Jorosali [Department Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Xu Yihuan; Chervoneva, Inna [Department of Pharmacology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States)

2011-03-01T23:59:59.000Z

90

On maximizing lifetime of a sensor cluster  

E-Print Network (OSTI)

We consider the energy consumed in radio transmission of a set of sensors forming a data gathering wireless network. Our objective is to enhance the lifetime of such networks by exploiting three system-level opportunities. Firstly, the number of bits to be transmitted can be reduced by taking advantage of the redundancy induced by spatio-temporal correlation in sensor data. Secondly, channel coding allows us to reduce transmission energy at the cost of increased transmission time. Thirdly, sensor nodes can be expected to operate collaboratively, allowing optimal management of distributed energy resources. Our main contribution lies in providing a framework to merge these ideas for energy conscious networking. We pose the problem of maximizing network lifetime as an optimal scheduling problem. We first consider a special case where data rate is linearly proportional to received signal power. In this scenario, we investigate both static and dynamic scheduling strategies. The optimal static schedule turns out to have a very simple form. For the dynamic case, we obtain an integer linear program formulation to find the optimal strategy. We then propose an efficient algorithm that exploits the special nature of the problem setting to quickly find the optimal solution. Finally, we consider the general case where data rates and signal power need not be linearly related and propose an algorithm to find the optimal transmission times subject to the deadline constraint imposed by the system. 1

Samar Agnihotri; Pavan Nuggehalli; H. S. Jamadagni

2005-01-01T23:59:59.000Z

91

Incidence of non-lung solid cancers in Czech uranium miners: A case-cohort study  

Science Conference Proceedings (OSTI)

Objectives: Uranium miners are chronically exposed to radon and its progeny, which are known to cause lung cancer and may be associated with leukemia. This study was undertaken to evaluate risk of non-lung solid cancers among uranium miners in Pribram region, Czech Republic. Methods: A retrospective stratified case-cohort study in a cohort of 22,816 underground miners who were employed between 1949 and 1975. All incident non-lung solid cancers were ascertained among miners who worked underground for at least 12 months (n=1020). A subcohort of 1707 subjects was randomly drawn from the same population by random sampling stratified on age. The follow-up period lasted from 1977 to 1996. Results: Relative risks comparing 180 WLM (90th percentile) of cumulative lifetime radon exposure to 3 WLM (10th percentile) were 0.88 for all non-lung solid cancers combined (95% CI 0.73-1.04, n=1020), 0.87 for all digestive cancers (95% CI 0.69-1.09, n=561), 2.39 for gallbladder cancer (95% CI 0.52-10.98, n=13), 0.79 for larynx cancer (95% CI 0.38-1.64, n=62), 2.92 for malignant melanoma (95% CI 0.91-9.42, n=23), 0.84 for bladder cancer (95% CI 0.43-1.65, n=73), and 1.13 for kidney cancer (95% CI 0.62-2.04, n=66). No cancer type was significantly associated with radon exposure; only malignant melanoma and gallbladder cancer showed elevated but non-significant association with radon. Conclusions: Radon was not significantly associated with incidence of any cancer of interest, although a positive association of radon with malignant melanoma and gallbladder cancer cannot be entirely ruled out. - Research highlights: {yields} Uranium miners are chronically exposed to radon. {yields} We evaluate risk of non-lung solid cancers among uranium miners. {yields} No cancer type was significantly associated with radon exposure. {yields} Malignant melanoma and gallbladder cancer showed non-significant elevated risk.

Kulich, M., E-mail: kulich@karlin.mff.cuni.cz [Department of Statistics, Faculty of Mathematics and Physics, Charles University, Sokolovska 83, CZ-186 75 Praha 8 (Czech Republic); Rericha, V. [Regional Hospital Pribram (Czech Republic)] [Regional Hospital Pribram (Czech Republic); Rericha, R. [Center of Epidemiological Studies, Pribram (Czech Republic)] [Center of Epidemiological Studies, Pribram (Czech Republic); Shore, D.L. [Westat, Inc., Durham, NC (United States)] [Westat, Inc., Durham, NC (United States); Sandler, D.P. [Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC (United States)] [Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC (United States)

2011-04-15T23:59:59.000Z

92

Determination of the historical changes in primary and secondary risk factors for cancer using U.S. public health records  

E-Print Network (OSTI)

Overall cancer mortality rates have risen from about 4% of all deaths in the early 20th century to about 25% of all deaths by the end of the century in the United States. To assess any potential hypotheses for this increase ...

Herrero Jimenez, Pablo, 1972-

2001-01-01T23:59:59.000Z

93

Potential health risks from postulated accidents involving the Pu-238 RTG (radioisotope thermoelectric generator) on the Ulysses solar exploration mission  

DOE Green Energy (OSTI)

Potential radiation impacts from launch of the Ulysses solar exploration experiment were evaluated using eight postulated accident scenarios. Lifetime individual dose estimates rarely exceeded 1 mrem. Most of the potential health effects would come from inhalation exposures immediately after an accident, rather than from ingestion of contaminated food or water, or from inhalation of resuspended plutonium from contaminated ground. For local Florida accidents (that is, during the first minute after launch), an average source term accident was estimated to cause a total added cancer risk of up to 0.2 deaths. For accidents at later times after launch, a worldwide cancer risk of up to three cases was calculated (with a four in a million probability). Upper bound estimates were calculated to be about 10 times higher. 83 refs.

Goldman, M. (California Univ., Davis, CA (USA)); Nelson, R.C. (EG and G Idaho, Inc., Idaho Falls, ID (USA)); Bollinger, L. (Air Force Inspection and Safety Center, Kirtland AFB, NM (USA)); Hoover, M.D. (Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (USA). Inhalation Toxicology Research Inst.); Templeton, W. (Pacific Northwest Lab., Richland, WA (USA)); Anspaugh, L. (Lawren

1990-11-02T23:59:59.000Z

94

Does Image-Guided Radiotherapy Improve Toxicity Profile in Whole Pelvic-Treated High-Risk Prostate Cancer? Comparison Between IG-IMRT and IMRT  

SciTech Connect

Purpose: To evaluate the impact of adding image-guided (IG) technique to intensity-modulated radiotherapy (IMRT) on dosimetric avoidance of organs at risk (OAR) and acute toxicities. Methods and Materials: A total of 25 consecutively treated patients (10 from National University Hospital and 15 from University of California San Francisco) with high-risk prostate cancer formed the study cohort. All received definitive IMRT with prophylactic nodal RT. Similar IMRT contouring and planning techniques were used at both centers. At University of California, San Francisco, intraprostatic fiducial markers were used for daily pretreatment on-line corrections (IG-IMRT). In contrast, at the National University Hospital, no fiducial markers were used (IMRT). At University of California, San Francisco, the planning target volume margins to the prostate were 2-3 mm. At the National University Hospital, they were 1 cm circumferentially, except for 0.5 cm posteriorly. The acute rectal and bladder toxicities and dosimetric endpoints to the planning target volume and organs at risk were compared. Results: The planning target volume dose coverage was not significantly different between IMRT and IG-IMRT for the prostate, seminal vesicles, and lymph nodes. The volume of rectum and bladder receiving {>=}40, {>=}60, and {>=}70 Gy were all significantly less using IG-IMRT (p <0.001). IG-IMRT yielded lower acute Radiation Therapy Oncology Group Grade 2 rectal (80% vs. 13%, p = 0.004) and bladder (60% vs. 13%, p = 0.014) toxicities. Conclusions: IG-IMRT, using daily target localization with fiducial markers, permits the use of smaller margins and correspondingly lower doses to the organs at risk, such as the rectum and bladder. These tangible gains appear to translate into lower clinically significant toxicities.

Chung, Hans T. [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore)], E-mail: hanstchung@gmail.com; Xia Ping; Chan, Linda W. [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Park-Somers, Eileen [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore); Roach, Mack [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States)

2009-01-01T23:59:59.000Z

95

Lifetime Evaluation of Elastomeric Polymers for Storage of Nuclear ...  

Science Conference Proceedings (OSTI)

Presentation Title, Lifetime Evaluation of Elastomeric Polymers for Storage of Nuclear Materials. Author(s), Elizabeth Hoffman, Eric Skidmore. On-Site Speaker  ...

96

New Tool Quantitatively Maps Minority-Carrier Lifetime of Multicrystal...  

NLE Websites -- All DOE Office Websites (Extended Search)

and Integration Laboratory (PDIL) to generate quantitative minority-carrier lifetime maps of multicrystalline silicon (mc-Si) bricks. This feat has been accomplished by using...

97

Using National Survey Data to Estimate Lifetimes of Residential Appliances  

E-Print Network (OSTI)

Life of Residential Appliances,” in ACEEE Summer Study onWhen do energy-efficient appliances generate energy savings?points. Assuming unchanging appliance lifetimes expands and

Lutz, James D.

2013-01-01T23:59:59.000Z

98

Characterizing Tumor Heterogeneity With Functional Imaging and Quantifying High-Risk Tumor Volume for Early Prediction of Treatment Outcome: Cervical Cancer as a Model  

Science Conference Proceedings (OSTI)

Purpose: Treatment response in cancer has been monitored by measuring anatomic tumor volume (ATV) at various times without considering the inherent functional tumor heterogeneity known to critically influence ultimate treatment outcome: primary tumor control and survival. This study applied dynamic contrast-enhanced (DCE) functional MRI to characterize tumors' heterogeneous subregions with low DCE values, at risk for treatment failure, and to quantify the functional risk volume (FRV) for personalized early prediction of treatment outcome. Methods and Materials: DCE-MRI was performed in 102 stage IB{sub 2}-IVA cervical cancer patients to assess tumor perfusion heterogeneity before and during radiation/chemotherapy. FRV represents the total volume of tumor voxels with critically low DCE signal intensity (20, >13, and >5 cm{sup 3}, respectively, significantly predicted unfavorable 6-year primary tumor control (p = 0.003, 7.3 Multiplication-Sign 10{sup -8}, 2.0 Multiplication-Sign 10{sup -8}) and disease-specific survival (p = 1.9 Multiplication-Sign 10{sup -4}, 2.1 Multiplication-Sign 10{sup -6}, 2.5 Multiplication-Sign 10{sup -7}, respectively). The FRVs were superior to the ATVs as early predictors of outcome, and the differentiating power of FRVs increased during treatment. Discussion: Our preliminary results suggest that functional tumor heterogeneity can be characterized by DCE-MRI to quantify FRV for predicting ultimate long-term treatment outcome. FRV is a novel functional imaging heterogeneity parameter, superior to ATV, and can be clinically translated for personalized early outcome prediction before or as early as 2-5 weeks into treatment.

Mayr, Nina A., E-mail: Nina.Mayr@osumc.edu [Department of Radiation Oncology, Ohio State University, Columbus, OH (United States); Huang Zhibin [Department of Radiation Oncology and Department of Physics, East Carolina University, Greenville, NC (United States); Wang, Jian Z. [Department of Radiation Oncology, Ohio State University, Columbus, OH (United States); Lo, Simon S. [Department of Radiation Oncology, Case Western Reserve University, Cleveland, OH (United States); Fan, Joline M. [Department of Molecular Biology, Stanford University, Stanford, CA (United States); Grecula, John C. [Department of Radiation Oncology, Ohio State University, Columbus, OH (United States); Sammet, Steffen [Department of Radiology, University of Chicago, Chicago, IL (United States); Department of Radiology, Ohio State University, Columbus, OH (United States); Sammet, Christina L. [Department of Radiology, University of Chicago, Chicago, IL (United States); Jia Guang; Zhang Jun; Knopp, Michael V.; Yuh, William T.C. [Department of Radiology, Ohio State University, Columbus, OH (United States)

2012-07-01T23:59:59.000Z

99

A Comparison of Acute and Chronic Toxicity for Men With Low-Risk Prostate Cancer Treated With Intensity-Modulated Radiation Therapy or {sup 125}I Permanent Implant  

SciTech Connect

Purpose: To compare the toxicity and biochemical outcomes of intensity-modulated radiation therapy (IMRT) and {sup 125}I transperineal permanent prostate seed implant ({sup 125}I) for patients with low-risk prostate cancer. Methods and Materials: Between 1998 and 2004, a total of 374 low-risk patients (prostate-specific antigen < 10 ng/ml, T1c-T2b, Gleason score of 6 or less, and no neoadjuvant hormones) were treated at Fox Chase Cancer Center (216 IMRT and 158 {sup 125}I patients). Median follow-up was 43 months for IMRT and 48 months for {sup 125}I. The IMRT prescription dose ranged from 74-78 Gy, and {sup 125}I prescription was 145 Gy. Acute and late gastrointestinal (GI) and genitourinary (GU) toxicity was recorded by using a modified Radiation Therapy Oncology Group scale. Freedom from biochemical failure was defined by using the Phoenix definition (prostate-specific antigen nadir + 2.0 ng/ml). Results: Patients treated by using IMRT were more likely to be older and have a higher baseline American Urological Association symptom index score, history of previous transurethral resection of the prostate, and larger prostate volumes. On multivariate analysis, IMRT was an independent predictor of lower acute and late Grade 2 or higher GU toxicity and late Grade 2 or higher GI toxicity. Three-year actuarial estimates of late Grade 2 or higher toxicity were 2.4% for GI and 3.5% for GU by using IMRT compared with 7.7% for GI and 19.2% for GU for {sup 125}I, respectively. Four-year actuarial estimates of freedom from biochemical failure were 99.5% for IMRT and 93.5% for {sup 125}I (p = 0.09). Conclusions: The IMRT and {sup 125}I produce similar outcomes, although IMRT appears to have less acute and late toxicity.

Eade, Thomas N. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Horwitz, Eric M. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States)], E-mail: eric.horwitz@fccc.edu; Ruth, Karen [Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, PA (United States); Buyyounouski, Mark K.; D'Ambrosio, David J.; Feigenberg, Steven J. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Chen, David Y.T. [Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Pollack, Alan [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States)

2008-06-01T23:59:59.000Z

100

Reference computations of public dose and cancer risk from airborne releases of uranium and Class W plutonium  

Science Conference Proceedings (OSTI)

This report presents ``reference`` computations that can be used by safety analysts in the evaluations of the consequences of postulated atmospheric releases of radionuclides from the Rocky Flats Environmental Technology Site. These computations deal specifically with doses and health risks to the public. The radionuclides considered are Class W Plutonium, all classes of Enriched Uranium, and all classes of Depleted Uranium. (The other class of plutonium, Y, was treated in an earlier report.) In each case, one gram of the respirable material is assumed to be released at ground leveL both with and without fire. The resulting doses and health risks can be scaled to whatever amount of release is appropriate for a postulated accident being investigated. The report begins with a summary of the organ-specific stochastic risk factors appropriate for alpha radiation, which poses the main health risk of plutonium and uranium. This is followed by a summary of the atmospheric dispersion factors for unfavorable and typical weather conditions for the calculation of consequences to both the Maximum Offsite Individual and the general population within 80 km (50 miles) of the site.

Peterson, V.L.

1995-06-06T23:59:59.000Z

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101

Stream data gathering in wireless sensor networks within expected lifetime  

Science Conference Proceedings (OSTI)

Sensor networks aim at collecting important sensor data for environment monitoring, e-health or hazardous conditions. Some applications do not need sensor networks with a long lifetime, such as monitoring an erupting volcano or monitoring hazardous conditions. ... Keywords: expected lifetime, sensor network, stream data gathering

Lei Shu; Zhangbing zhou; Antonio Aguilar; Manfred Hauswirth

2007-08-01T23:59:59.000Z

102

Lifetime embrittlement of reactor core materials  

DOE Green Energy (OSTI)

Over a core lifetime, the reactor materials Zircaloy-2, Zircaloy-4, and hafnium may become embrittled due to the absorption of corrosion- generated hydrogen and to neutron irradiation damage. Results are presented on the effects of fast fluence on the fracture toughness of wrought Zircaloy-2, Zircaloy-4, and hafnium; Zircaloy-4 to hafnium butt welds; and hydrogen precharged beta treated and weld metal Zircaloy-4 for fluences up to a maximum of approximately 150 x 10{sup 24} n/M{sup 2} (> 1 Mev). While Zircaloy-4 did not exhibit a decrement in K{sub IC} due to irradiation, hafnium and butt welds between hafnium and Zircaloy-4 are susceptible to embrittlement with irradiation. The embrittlement can be attributed to irradiation strengthening, which promotes cleavage fracture in hafnium and hafnium-Zircaloy welds, and, in part, to the lower chemical potential of hydrogen in Zircaloy-4 compared to hafnium, which causes hydrogen, over time, to drift from the hafnium end toward the Zircaloy-4 end and to precipitate at the interface between the weld and base-metal interface. Neutron radiation apparently affects the fracture toughness of Zircaloy-2, Zircaloy-4, and hafnium in different ways. Possible explanations for these differences are suggested. It was found that Zircaloy-4 is preferred over Zircaloy-2 in hafnium-to- Zircaloy butt-weld applications due to its absence of a radiation- induced reduction in K{sub IC} plus its lower hydrogen absorption characteristics compared with Zircaloy-2.

Kreyns, P.H..; Bourgeois, W.F.; Charpentier, P.L.; Kammenzind, B.F.; Franklin, D.G. [Bettis Atomic Power Lab., West Mifflin, PA (United States); White, C.J. [Knolls Atomic Power Lab., Schenectady, NY (United States)

1994-08-01T23:59:59.000Z

103

The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort  

E-Print Network (OSTI)

Study cohort. Breast Cancer Research 2011 13:R37. SubmitLee et al. Breast Cancer Research 2011, 13:R37 http://Lee et al. Breast Cancer Research 2011, 13:R37 http://

2011-01-01T23:59:59.000Z

104

Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort  

E-Print Network (OSTI)

Teachers Study cohort Breast Cancer Research 2010, 12:R35SG, Ma et al. Breast Cancer Research 2010, 12:R35 http://car- Ma et al. Breast Cancer Research 2010, 12:R35 http://

2010-01-01T23:59:59.000Z

105

Neutron lifetime measurements using gravitationally trapped ultracold neutrons  

E-Print Network (OSTI)

Our experiment using gravitationally trapped ultracold neutrons (UCN) to measure the neutron lifetime is reviewed. Ultracold neutrons were trapped in a material bottle covered with perfluoropolyether. The neutron lifetime was deduced from comparison of UCN losses in the traps with different surface-to-volume ratios. The precise value of the neutron lifetime is of fundamental importance to particle physics and cosmology. In this experiment, the UCN storage time is brought closer to the neutron lifetime than in any experiments before:the probability of UCN losses from the trap was only 1% of that for neutron beta decay. The neutron lifetime obtained,878.5+/-0.7stat+/-0.3sys s, is the most accurate experimental measurement to date.

A. P. Serebrov; V. E. Varlamov; A. G. Kharitonov; A. K. Fomin; Yu. N. Pokotilovski; P. Geltenbort; I. A. Krasnoschekova; M. S. Lasakov; R. R. Taldaev; A. V. Vassiljev; O. M. Zherebtsov

2007-02-06T23:59:59.000Z

106

Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant  

SciTech Connect

Purpose: Transforming growth factor-beta1 is related to adverse events in radiochemotherapy. We investigated TGFB1 genetic variability in relation to quality of life-impairing acute organ toxicity (QAOT) of neoadjuvant radiochemotherapy under clinical trial conditions. Methods and Materials: Two independent patient cohorts (n = 88 and n = 75) diagnosed with International Union Against Cancer stage II/III rectal cancer received neoadjuvant radiation doses of 50.4 Gy combined with 5-fluorouracil-based chemotherapy. Toxicity was monitored according to Common Terminology Criteria for Adverse Events. QAOT was defined as a CTCAE grade {>=}2 for at least one case of enteritis, proctitis, cystitis, or dermatitis. Nine germline polymorphisms covering the common genetic diversity in the TGFB1 gene were genotyped. Results: In both cohorts, all patients carrying the TGFB1 Pro25 variant experienced QAOT (positive predictive value of 100%, adjusted p = 0.0006). In a multivariate logistic regression model, gender, age, body mass index, type of chemotherapy, or disease state had no significant impact on QAOT. Conclusion: The TGFB1 Pro25 variant could be a relevant marker for individual treatment stratification and carriers may benefit from adaptive clinical care or specific radiation techniques.

Schirmer, Markus Anton; Mergler, Caroline Patricia Nadine [Department of Clinical Pharmacology, University Medical Center, Goettingen (Germany); Rave-Fraenk, Margret; Herrmann, Markus Karl; Hennies, Steffen [Department of Radiotherapy and Radiooncology, University Medical Center, Goettingen (Germany); Gaedcke, Jochen; Conradi, Lena-Christin; Jo, Peter [Department of General and Visceral Surgery, University Medical Center, Goettingen (Germany); Beissbarth, Tim [Department of Medical Statistics, University Medical Center, Goettingen (Germany); Hess, Clemens Friedrich [Department of Radiotherapy and Radiooncology, University Medical Center, Goettingen (Germany); Becker, Heinz; Ghadimi, Michael [Department of General and Visceral Surgery, University Medical Center, Goettingen (Germany); Brockmoeller, Juergen [Department of Clinical Pharmacology, University Medical Center, Goettingen (Germany); Christiansen, Hans [Department of Radiotherapy and Radiooncology, University Medical Center, Goettingen (Germany); Wolff, Hendrik Andreas, E-mail: hendrik.wolff@med.uni-goettingen.de [Department of Radiotherapy and Radiooncology, University Medical Center, Goettingen (Germany)

2012-05-01T23:59:59.000Z

107

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the Breast Cancer Association Consortium: a combined case-control study  

E-Print Network (OSTI)

7HT, UK. Breakthrough Breast Cancer Research Centre, TheInstitute of Cancer Research, 237 Fulman Road, London,control study. Breast Cancer Research 2010 12:R110. Submit

2010-01-01T23:59:59.000Z

108

Multi-parametric numerical simulation of age-specific cancer rates in human populations  

E-Print Network (OSTI)

The CancerFit computer program allows cancer researchers to analyze epidemiologic data describing the age-specific risk of cancer in terms of hypotheses about historical environmental risks, the heritability of cancer, the ...

Kogel, John, 1981-

2004-01-01T23:59:59.000Z

109

Cancer and work in Canada with particular reference to occupational risk factors in breast cancer patients in one community and related selected research methods used to investigate those factors.  

E-Print Network (OSTI)

??Cancer represents a major cause of human morbidity and mortality. There is no scientific consensus regarding cancer causality or prevention. Occupational exposure potentially remains a… (more)

Brophy, James Thomas

2004-01-01T23:59:59.000Z

110

Lifetime Extension of the Phenix Plant  

SciTech Connect

The French fast reactor prototype Phenix was put into commercial operation in 1974. The total time of power operation of the plant is [approximately]100000 h representing 3860 equivalent fuel power days (EFPD). With the initial objective of the demonstration of fast breeder reactors achieved, since the early 1990s, the role of the reactor as an irradiation facility has been emphasized, particularly in support of the Commissariat a l'Energie Atomique research and development program on long-lived radioactive waste transmutation. This new objective required an extension of the planned reactor lifetime. A major renovation program was carried out in the plant from 1994 to 2003, involving safety upgrading, component inspections and repairs, and the 10-yr statutory maintenance. The main work consisted of the addition of a backup control rod to the reactor; improvement of earthquake protection by reinforcement of buildings and components and replacement of the emergency water cooling circuit; improvement of protection against sodium fire by partitioning the secondary sodium circuit in the steam generator building, reinforcement of steam generator casing, and installation of an antiwhip system on the high-pressure steam pipes; replacement of hot parts of the 321 stainless steel secondary loops and steam generator modules, affected by delayed reheat cracking; special inspections of the reactor internal structures to demonstrate their good condition. An extensive plant requalification program was carried out following the renovation work, and the plant resumed power operation in June 2003. Six operating cycles are planned, representing a total irradiation time of 720 EFPD equivalent to [approximately]5.5 yr of operation.

Guidez, J. [Commissariat a l'Energie Atomique (France); Le Coz, P. [Commissariat a l'Energie Atomique (France); Martin, L. [Commissariat a l'Energie Atomique (France); Mariteau, P. [Electricite de France (France); Dupraz, R. [Framatome-ANP (France)

2005-04-15T23:59:59.000Z

111

Study of familial breast cancer: identifying additional breast cancer susceptibility loci;.  

E-Print Network (OSTI)

??Breast cancer is a serious public health concern and despite intensive research, the etiology of breast cancer is poorly understood. Known risk factors explain only… (more)

Allen-Brady, Kristina Lisa

2006-01-01T23:59:59.000Z

112

Using decision analysis to determine the cost-effectiveness of intensity-modulated radiation therapy in the treatment of intermediate risk prostate cancer  

SciTech Connect

Background: The specific aim of this study is to evaluate the cost-effectiveness of intensity-modulated radiation therapy (IMRT) compared with three-dimensional conformal radiation therapy (3D-CRT) in the treatment of a 70-year-old with intermediate-risk prostate cancer. Methods: A Markov model was designed with the following states; posttreatment, hormone therapy, chemotherapy, and death. Transition probabilities from one state to another were calculated from rates derived from the literature for IMRT and 3D-CRT. Utility values for each health state were obtained from preliminary studies of preferences conducted at Fox Chase Cancer Center. The analysis took a payer's perspective. Expected mean costs, cost-effectiveness scatterplots, and cost acceptability curves were calculated with commercially available software. Results: The expected mean cost of patients undergoing IMRT was $47,931 with a survival of 6.27 quality-adjusted life years (QALYs). The expected mean cost of patients having 3D-CRT was $21,865 with a survival of 5.62 QALYs. The incremental cost-effectiveness comparing IMRT with CRT was $40,101/QALYs. Cost-effectiveness acceptability curve analysis revealed a 55.1% probability of IMRT being cost-effective at a $50,000/QALY willingness to pay. Conclusion: Intensity-modulated radiation therapy was found to be cost-effective, however, at the upper limits of acceptability. The results, however, are dependent on the assumptions of improved biochemical disease-free survival with fewer patients undergoing subsequent salvage therapy and improved quality of life after the treatment. In the absence of prospective randomized trials, decision analysis can help inform physicians and health policy experts on the cost-effectiveness of emerging technologies.

Konski, Andre [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States)]. E-mail: andre.konski@fccc.edu; Watkins-Bruner, Deborah [Department of Population Sciences, Fox Chase Cancer Center, Philadelphia, PA (United States); Feigenberg, Steven [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Hanlon, Alexandra [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Kulkarni, Sachin M.S. [Department of Population Sciences, Fox Chase Cancer Center, Philadelphia, PA (United States); Beck, J. Robert [Department of Information and Science Technologies, Fox Chase Cancer Center, Philadelphia, PA (United States); Horwitz, Eric M. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Pollack, Alan [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States)

2006-10-01T23:59:59.000Z

113

Lifetime of the Highly Efficient H- Ion Sources  

Science Conference Proceedings (OSTI)

Factors limiting the operating lifetime of Compact Surface Plasma Sources (CSPS) are analyzed and possible treatments for lifetime enhancement are considered. Noiseless discharges with lower gas and cesium densities are produced in experiments with modified discharge cells. With these discharge cells it is possible to increase the emission aperture and extract the same beam with a lower discharge current and with correspondingly increased source lifetime. A design of an advanced CSPS is presented. Optimization of the discharge cells in a Penning H{sup -} ion source is a viable method for increasing the phase space of the stable region for noiseless discharge production. With this method, cesium usage would be decreased, potentially resulting in longer source lifetimes.

Bollinger, D.S.; /Fermilab; Dudnikov, V.G.; /MUONS Inc., Batavia; Faircloth, D.C.; Lawrie, S.R.; /Rutherford

2012-05-01T23:59:59.000Z

114

Long lifetime operation of an ArF-excimer laser  

Science Conference Proceedings (OSTI)

lifetime of a discharge-excited ArF-excimer laser is pre- sented. The three ... are CF4 generation in the laser gas, color-center forma- tion in the optics and input ...

115

Lifetime of solar flare particles in coronal storage regions  

Science Conference Proceedings (OSTI)

Most discussions of lifetime of flare particles in the solar corona have ... However, it is quite possible that the solar cosmic rays are not imbedded in I0 a K coronal.

116

Orientation-Dependent Entanglement Lifetime in a Squeezed Atomic Clock  

E-Print Network (OSTI)

We study experimentally the application of a class of entangled states, squeezed spin states, to the improvement of atomic-clock precision. In the presence of anisotropic noise, the entanglement lifetime is strongly dependent ...

Leroux, Ian Daniel

117

Measurement of the lifetimes of B meson mass eigenstates  

E-Print Network (OSTI)

In this dissertation, we present the results of the average lifetime measurements in ..., ..., and ... decays, as well as the results of a time-dependent angular analysis of ... and ... decays. The time-dependent angular ...

Anikeev, Konstantin

2004-01-01T23:59:59.000Z

118

Microchip Technology for High-Throughput Cancer Pathology  

E-Print Network (OSTI)

Sequencing in Cancer Research . . . . 80 Appendix A: High-the Warburg Effect. Cancer Research, 2006. 66(18): p. 8927-Breast Cancer Risk. Cancer Research, 2007. 67(10): p. 4687-

Duberow, Jr, David Paul

2009-01-01T23:59:59.000Z

119

Orientation-Dependent Entanglement Lifetime in a Squeezed Atomic Clock  

E-Print Network (OSTI)

We study experimentally the lifetime of a special class of entangled states in an atomic clock, squeezed spin states. In the presence of anisotropic noise, their lifetime is strongly dependent on squeezing orientation. We measure the Allan deviation spectrum of a clock operated with a phase-squeezed input state. For integration times up to 50 s the squeezed clock achieves a given precision 2.8(3) times faster than a clock operating at the standard quantum limit.

Ian D. Leroux; Monika H. Schleier-Smith; Vladan Vuleti?

2010-04-10T23:59:59.000Z

120

Pelvic Lymph Node Status Assessed by 18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Low-Risk Group for Distant Recurrence in Locally Advanced Cervical Cancer: A Prospective Study  

SciTech Connect

Purpose: To develop a prediction model to identify a low-risk group for distant recurrence in patients with locally advanced cervical cancer treated by concurrent chemoradiation. Methods and Materials: Prospectively, 62 patients with locally advanced cervical cancer were recruited as a training cohort. Clinical variables and parameters obtained from positron emission tomography (PET) and magnetic resonance imaging were analyzed by logistic regression. For the test set, 54 patients were recruited independently. To identify the low-risk group, negative likelihood ratio (LR) less than 0.2 was set to be a cutoff. Results: Among the training cohort, multivariate logistic analysis revealed that advanced International Federation of Gynecology and Obstetrics (FIGO) stage and a high serum squamous cancer cell (SCC) antigen level were significant risk factors (p = 0.015 and 0.025, respectively). Using the two parameters, criteria to determine a low-risk subset for distant recurrence were postulated: (1) FIGO Stage IIB or less and (2) pretreatment SCC < 2.4 (Model A). Positive pelvic node on PET completely predicted all cases with distant recurrence and thus was considered as another prediction model (Model B). In the test cohort, although Model A did not showed diagnostic performance, Model B completely predicted all cases with distant recurrence and showed a sensitivity of 100% with negative LR of 0. Across the training and test cohort (n = 116), the false negative rate was 0 (95% confidence interval 0%-7.6%). Conclusions: Positive pelvic node on PET is a useful marker in prediction of distant recurrence in patients with locally advanced cervical cancer who are treated with concurrent chemoradiation.

Kang, Sokbom, E-mail: sokbom@ncc.re.k [Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Park, Jung-Yeol; Lim, Myung-Chul; Song, Yong-Joong; Park, Se-Hyun [Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Kim, Seok-Ki [Center for Diagnostic Oncology, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Chung, Dae-Chul; Seo, Sang-Soo; Kim, Joo-Young; Park, Sang-Yoon [Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)

2011-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Anterior Myocardial Territory May Replace the Heart as Organ at Risk in Intensity-Modulated Radiotherapy for Left-Sided Breast Cancer  

SciTech Connect

Purpose: We investigated whether the heart could be replaced by the anterior myocardial territory (AMT) as the organ at risk (OAR) in intensity-modulated radiotherapy (IMRT) of the breast for patients with left-sided breast cancer. Methods and Materials: Twenty-three patients with left-sided breast cancer who received postoperative radiation after breast-conserving surgery were studied. For each patient, we generated five IMRT plans including heart (H), left ventricle (LV), AMT, LV+AMT, and H+LV as the primary OARs, respectively, except both lungs and right breast, which corresponded to IMRT(H), IMRT(LV), IMRT(AMT), IMRT(LV+AMT), and IMRT(H+LV). For the planning target volumes and OARs, the parameters of dose-volume histograms were compared. Results: The homogeneity index, conformity index, and coverage index were not compromised significantly in IMRT(AMT), IMRT(LV) and IMRT(LV+ AMT), respectively, when compared with IMRT(H). The mean dose to the heart, LV, and AMT decreased 5.3-21.5% (p < 0.05), 19.9-29.5% (p < 0.05), and 13.3-24.5% (p < 0.05), respectively. Similarly, the low (e.g., V5%), middle (e.g., V20%), and high (e.g., V30%) dose-volume of the heart, LV, and AMT decreased with different levels. The mean dose and V10% of the right lung increased by 9.2% (p < 0.05) and 27.6% (p < 0.05), respectively, in IMRT(LV), and the mean dose and V5% of the right breast decreased significantly in IMRT(AMT) and IMRT(LV+AMT). IMRT(AMT) was the preferred plan and was then compared with IMRT(H+LV); the majority of dose-volume histogram parameters of OARs including the heart, LV, AMT, both lungs, and the right breast were not statistically different. However, the low dose-volume of LV increased and the middle dose-volume decreased significantly (p < 0.05) in IMRT(AMT). Also, those of the right lung (V10%, V15%) and right breast (V5%, V10%) decreased significantly (p < 0.05). Conclusions: The AMT may replace the heart as the OAR in left-sided breast IMRT after breast-conserving surgery to decrease the radiation dose to the heart.

Tan Wenyong [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan (China); Liu Dong [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Xue Chenbin [Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan (China); Xu Jiaozhen; Li Beihui [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Chen Zhengwang [Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan (China); Hu Desheng [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Wang Xionghong, E-mail: tanwyym@yahoo.com.cn [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China)

2012-04-01T23:59:59.000Z

122

High-Risk Prostate Cancer With Gleason Score 8-10 and PSA Level {<=}15 ng/ mL Treated With Permanent Interstitial Brachytherapy  

SciTech Connect

Purpose: With widespread prostate-specific antigen (PSA) screening, there has been an increase in men diagnosed with high-risk prostate cancer defined by a Gleason score (GS) {>=}8 coupled with a relatively low PSA level. The optimal management of these patients has not been defined. Cause-specific survival (CSS), biochemical progression-free survival (bPFS), and overall survival (OS) were evaluated in brachytherapy patients with a GS {>=}8 and a PSA level {<=}15 ng/mL with or without androgen-deprivation therapy (ADT). Methods and Materials: From April 1995 to October 2005, 174 patients with GS {>=}8 and a PSA level {<=}15 ng/mL underwent permanent interstitial brachytherapy. Of the patients, 159 (91%) received supplemental external beam radiation, and 113 (64.9%) received ADT. The median follow-up was 6.6 years. The median postimplant Day 0 minimum percentage of the dose covering 90% of the target volume was 121.1% of prescription dose. Biochemical control was defined as a PSA level {<=}0.40 ng/mL after nadir. Multiple parameters were evaluated for impact on survival. Results: Ten-year outcomes for patients without and with ADT were 95.2% and 92.5%, respectively, for CSS (p = 0.562); 86.5% and 92.6%, respectively, for bPFS (p = 0.204); and 75.2% and 66.0%, respectively, for OS (p = 0.179). The median post-treatment PSA level for biochemically controlled patients was <0.02 ng/mL. Multivariate analysis failed to identify any predictors for CSS, whereas bPFS and OS were most closely related to patient age. Conclusions: Patients with GS {>=}8 and PSA level {<=}15 ng/mL have excellent bPFS and CSS after brachytherapy with supplemental external beam radiotherapy. The use of ADT did not significantly impact bPFS, CSS, or OS.

Fang, L. Christine [Department of Radiation Oncology, University of Washington, Seattle, WA (United States); Merrick, Gregory S., E-mail: gmerrick@urologicresearchinstitute.org [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV (United States); Butler, Wayne M.; Galbreath, Robert W.; Murray, Brian C.; Reed, Joshua L. [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV (United States); Adamovich, Edward [Department of Pathology, Wheeling Hospital, Wheeling, WV (United States); Wallner, Kent E. [Puget Sound Veterans Affairs Hospital, Seattle, WA (United States)

2011-11-15T23:59:59.000Z

123

Models for Battery Reliability and Lifetime: Applications in Design and Health Management (Presentation)  

DOE Green Energy (OSTI)

This presentation discusses models for battery reliability and lifetime and the Battery Ownership Model.

Smith, K.; Neubauer, J.; Wood, E.; Jun, M.; Pesaran, A.

2013-06-01T23:59:59.000Z

124

Beam lifetime and limitations during low-energy RHIC operation  

SciTech Connect

The low-energy physics program at the Relativistic Heavy Ion Collider (RHIC), motivated by a search for the QCD phase transition critical point, requires operation at low energies. At these energies, large nonlinear magnetic field errors and large beam sizes produce low beam lifetimes. A variety of beam dynamics effects such as Intrabeam Scattering (IBS), space charge and beam-beam forces also contribute. All these effects are important to understand beam lifetime limitations in RHIC at low energies. During the low-energy RHIC physics run in May-June 2010 at beam {gamma} = 6.1 and {gamma} = 4.1, gold beam lifetimes were measured for various values of space-charge tune shifts, transverse acceptance limitation by collimators, synchrotron tunes and RF voltage. This paper summarizes our observations and initial findings.

Fedotov, A.V.; Bai, M.; Blaskiewicz, M.; Fischer, W.; Kayran, D.; Montag, C.; Satogata, T.; Tepikian, S.; Wang, G.

2011-03-28T23:59:59.000Z

125

Better Methods for Predicting Lifetimes of Seal Materials  

Science Conference Proceedings (OSTI)

We have been working for many years to develop better methods for predicting the lifetimes of polymer materials. Because of the recent interest in extending the lifetimes of nuclear weapons and the importance of environmental seals (o-rings, gaskets) for protecting weapon interiors against oxygen and water vapor, we have recently turned our attention to seal materials. Perhaps the most important environmental o-ring material is butyl rubber, used in various military applications. Although it is the optimum choice from a water permeability perspective, butyl can be marginal from an aging point-of-view. The purpose of the present work was to derive better methods for predicting seal lifetimes and applying these methods to an important butyl material, Parker compound B6 12-70.

Celina, M.; Gillen, K.T.; Keenan, M.R.

1999-03-16T23:59:59.000Z

126

Spectrum Fatigue Lifetime and Residual Strength for Fiberglass Laminates  

SciTech Connect

This report addresses the effects of spectrum loading on lifetime and residual strength of a typical fiberglass laminate configuration used in wind turbine blade construction. Over 1100 tests have been run on laboratory specimens under a variety of load sequences. Repeated block loading at two or more load levels, either tensile-tensile, compressive-compressive, or reversing, as well as more random standard spectra have been studied. Data have been obtained for residual strength at various stages of the lifetime. Several lifetime prediction theories have been applied to the results. The repeated block loading data show lifetimes that are usually shorter than predicted by the most widely used linear damage accumulation theory, Miner's sum. Actual lifetimes are in the range of 10 to 20 percent of predicted lifetime in many cases. Linear and nonlinear residual strength models tend to fit the data better than Miner's sum, with the nonlinear providing a better fit of the two. Direct tests of residual strength at various fractions of the lifetime are consistent with the residual strength models. Load sequencing effects are found to be insignificant. The more a spectrum deviates from constant amplitude, the more sensitive predictions are to the damage law used. The nonlinear model provided improved correlation with test data for a modified standard wind turbine spectrum. When a single, relatively high load cycle was removed, all models provided similar, though somewhat non-conservative correlation with the experimental results. Predictions for the full spectrum, including tensile and compressive loads were slightly non-conservative relative to the experimental data, and accurately captured the trend with varying maximum load. The nonlinear residual strength based prediction with a power law S-N curve extrapolation provided the best fit to the data in most cases. The selection of the constant amplitude fatigue regression model becomes important at the lower stress, higher cycle loading cases. The residual strength models may provide a more accurate estimate of blade lifetime than Miner's rule for some loads spectra. They have the added advantage of providing an estimate of current blade strength throughout the service life.

WAHL, NEIL K.; MANDELL, JOHN F.; SAMBORSKY, DANIEL D.

2002-03-01T23:59:59.000Z

127

Lifetime Prediction for Supercapacitor-powered Wireless Sensor Nodes  

E-Print Network (OSTI)

Lifetime Prediction for Supercapacitor-powered Wireless Sensor Nodes Christian Renner, J step towards reaching this goal: It explores discharging-characteristics of supercapacitors, discusses-ion polymers, supercapacitors can last for 10 years or even more. Superca- pacitors do not need a complex

Turau, Volker

128

Produced water radionuclide hazard/risk assessment, Phase 1  

SciTech Connect

Petroleum production may be accompanied by the production of saline water, called produced water.'' Produced water discharged into freshwater streams, estuaries, coastal and outer continental shelf waters can contained enhanced levels of radium isotopes. This document reports on the first phase of a study to estimate the risk to human health and the environment from radium discharged in produced water. The study involved five major steps: (1) evaluate the usefulness of available produced water outfall data for developing estimates of radium environmental concentrations; (2) review the literature on the bioaccumulation of radium by aquatic organism; (3) review the literature on the effects of radiation on aquatic organisms; (4) review the information available concerning the human health risks associated with exposure to Ra-226 and Ra-228 and (5) perform a conservative, screening-level assessment of the health and environmental risks posed by Ra-226 and Ra-228 discharged in produced waters. A screening-level analysis was performed to determine whether radium discharged to coastal Louisiana in produced waters presents potential health or environmental risks requiring further study. This conservative assessment suggested that no detectable impact on populations of fish, molluscs or crustaceans from radium discharged in produced waters is likely. The analysis also suggested that there is a potential for risk were an individual to ingest a large amount of seafood harvested near a produced water discharge point over a lifetime. The number of excess cancers predicted per year under a conservative scenario is comparable to those expected to result from background concentrations of radium.

Hamilton, L.D.; Meinhold, A.F.; Nagy, J.

1991-06-01T23:59:59.000Z

129

Produced water radionuclide hazard/risk assessment, Phase 1  

Science Conference Proceedings (OSTI)

Petroleum production may be accompanied by the production of saline water, called ``produced water.`` Produced water discharged into freshwater streams, estuaries, coastal and outer continental shelf waters can contained enhanced levels of radium isotopes. This document reports on the first phase of a study to estimate the risk to human health and the environment from radium discharged in produced water. The study involved five major steps: (1) evaluate the usefulness of available produced water outfall data for developing estimates of radium environmental concentrations; (2) review the literature on the bioaccumulation of radium by aquatic organism; (3) review the literature on the effects of radiation on aquatic organisms; (4) review the information available concerning the human health risks associated with exposure to Ra-226 and Ra-228 and (5) perform a conservative, screening-level assessment of the health and environmental risks posed by Ra-226 and Ra-228 discharged in produced waters. A screening-level analysis was performed to determine whether radium discharged to coastal Louisiana in produced waters presents potential health or environmental risks requiring further study. This conservative assessment suggested that no detectable impact on populations of fish, molluscs or crustaceans from radium discharged in produced waters is likely. The analysis also suggested that there is a potential for risk were an individual to ingest a large amount of seafood harvested near a produced water discharge point over a lifetime. The number of excess cancers predicted per year under a conservative scenario is comparable to those expected to result from background concentrations of radium.

Hamilton, L.D.; Meinhold, A.F.; Nagy, J.

1991-06-01T23:59:59.000Z

130

Phase II Study of Long-Term Androgen Suppression With Bevacizumab and Intensity-Modulated Radiation Therapy (IMRT) in High-Risk Prostate Cancer  

Science Conference Proceedings (OSTI)

Purpose: We report a Phase II trial assessing the acute and late toxicities of intensity-modulated radiation therapy (IMRT), long-term androgen suppression (LTAS), and bevacizumab in patients with high-risk localized prostate cancer. Methods and Materials: We treated 18 patients with LTAS with bicalutamide and goserelin in combination with bevacizumab and IMRT. Bevacizumab (10 mg/kg every 2 weeks) was administered for the first 16 weeks, and 15 mg/kg was then given every 3 weeks for 12 additional weeks, with an IMRT dose of 77.9 Gy to the prostate, 64.6 Gy to the seminal vesicles, and 57 Gy to the pelvic lymph nodes. Patients were eligible if they had clinical stage T2b to T4, a Gleason sum score of 8 to 10, or a prostate- specific antigen level of 20ng/mL or greater. The primary endpoint of the study was evaluation of acute and late toxicities. Results: The median age was 69 years, with a median pretreatment prostate-specific antigen level of 12.5 ng/mL and Gleason score of 8. The pretreatment clinical stage was T1c in 4 patients, T2 in 11, and T3 in 3. All patients completed IMRT with median follow-up of 34 months (range, 28-40 months) The most common Grade 2 or higher toxicities were hypertension (61% of patients with Grade 2 and 11% with Grade 3), proteinuria (28% with Grade 2 and 6% with Grade 3), and leucopenia (28% with Grade 2). No Grade 4 or higher acute toxicities were reported. Late toxicities included proctitis (6% of patients with Grade 2 and 11% with Grade 3), rectal bleeding (6% with Grade 2 and 11% with Grade 3), hematuria (6% with Grade 2), proteinuria (17% with Grade 2), hyponatremia (6% with Grade 3), cystitis (6% with Grade 3), and urinary retention (6% with Grade 2 and 11% with Grade 3). Grade 4 prostatitis occurred in 1 patient (6%). Conclusions: Bevacizumab does not appear to exacerbate the acute effects of IMRT. Late toxicities may have been worsened with this regimen. Further investigations of bevacizumab with LTAS and IMRT should be performed cautiously.

Vuky, Jacqueline, E-mail: vukyja@ohsu.edu [Section of Community Hematology/Oncology, Knight Cancer Institute, Oregon Health Sciences University, Portland, OR (United States); Pham, Huong T. [Section of Hematology/Oncology and Radiation Oncology, Virginia Mason Medical Center, Seattle, WA (United States); Warren, Sarah; Douglass, Erika [Benaroya Research Institute, Virginia Mason Medical Center, Seattle, WA (United States); Badiozamani, Kasra [Section of Hematology/Oncology and Radiation Oncology, Virginia Mason Medical Center, Seattle, WA (United States); Madsen, Berit; Hsi, Alex [Peninsula Cancer Center, Poulsbo, WA (United States); Song Guobin [Section of Hematology/Oncology and Radiation Oncology, Virginia Mason Medical Center, Seattle, WA (United States)

2012-03-15T23:59:59.000Z

131

Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study  

E-Print Network (OSTI)

Gierach3,4, Nicholas J Wareham2, Ulf Ekelund2, Albert R Hollenbeck5, Arthur Schatzkin1 and Michael F Leitzmann6 Address: 1Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive... and Preventive Medicine, University Medical Center Regensburg, Regensburg, Germany Email: Tricia M Peters* - tricia.peters@mrc-epid.cam.ac.uk; Steven C Moore - moorest@mail.nih.gov; Gretchen L Gierach - gierachg@mail.nih.gov; Nicholas J Wareham - nick...

Peters, Tricia M; Moore, Steven C; Gierach, Gretchen L; Wareham, Nicholas J; Ekelund, Ulf; Hollenbeck, Albert R; Schatzkin, Arthur; Leitzmann, Michael F

2009-10-01T23:59:59.000Z

132

Online Prediction of Battery Lifetime for Embedded and Mobile Devices  

E-Print Network (OSTI)

This paper presents a novel, history-based, statistical technique for online battery lifetime prediction. The approach first takes a one-time, full cycle, voltage measurement of a constant load, and uses it to transform the partial voltage curve of the current workload into a form with robust predictability. Based on the transformed history curve, we apply a statistical method to make a lifetime prediction. We investigate the performance of the implementation of our approach on a widely used mobile device (HP iPAQ) running Linux, and compare it to two similar battery prediction technologies: ACPI and Smart Battery. We employ twenty-two constant and variable workloads to verify the effcacy of our approach. Our results show that this approach is efficient, accurate, and able to adapt to different systems and batteries easily.

Ye Wen; Rich Wolski; Chandra Krintz

2003-01-01T23:59:59.000Z

133

Public Affairs Office: Livermore Lab Physicist Dates Lifetime of Solar  

NLE Websites -- All DOE Office Websites (Extended Search)

Dating the Solar System: Where Were You When the Solar System Was Being Formed? Dating the Solar System: Where Were You When the Solar System Was Being Formed? Chemistry & Materials Science Directorate, LLNL Chronology of the early Solar System from chondrule-bearing calcium-aluminium-rich inclusions Nature, April 21, 2005 Building Planets at PSI: The Origin of the Solar System Planetary Science Institute Social Media Logos Follow LLNL on YouTube Subscribe to LLNL's RSS feed Follow LLNL on Facebook Follow LLNL on Twitter Follow LLNL on Flickr Contact: Anne M. Stark Phone: (925) 422-9799 E-mail: stark8@llnl.gov FOR IMMEDIATE RELEASE April 20, 2005 NR-05-04-02 Livermore Lab physicist dates lifetime of solar nebula at two million years LIVERMORE, Calif. - The oxygen and magnesium content of some of the oldest objects in the universe are giving clues to the lifetime of the

134

A Measurement of the D+(s) lifetime  

SciTech Connect

A high statistics measurement of the D{sub s}{sup +} lifetime from the Fermilab fixed-target FOCUS photoproduction experiment is presented. They describe the analysis of the two decay modes, D{sub s}{sup +} {yields} {phi}(1020){pi}{sup +} and D{sub s}{sup +} {yields} {bar K}*(892){sup 0}K{sup +}, used for the measurement. The measured lifetime is 507.4 {+-} 5.5(stat.) {+-} 5.1(syst.) is using 8961 {+-} 105 D{sub s}{sup +} {yields} {phi}(1020){pi}{sup +} and 4680 {+-} 90 D{sub s}{sup +} {yields} {bar K}*(892){sup 0} K{sup +} decays. This is a significant improvement over the present world average.

Link, J.M.; Yager, P.M.; /UC, Davis; Anjos, J.C.; Bediaga, I.; Castromonte, C.; Machado, A.A.; Magnin, J.; Massafferi, A.; de Miranda, J.M.; Pepe, I.M.; Polycarpo, E.; dos Reis, A.C.; /Rio de Janeiro, CBPF; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vazquez, F.; /CINVESTAV, IPN; Agostino, L.; Cinquini, L.; Cumalat, J.P. /Colorado U. /Fermilab /Frascati /Guanajuato U. /Illinois U., Urbana /Indiana U. /Korea U. /Kyungpook Natl. U. /INFN, Milan /Milan U. /North Carolina U. /Pavia U. /INFN, Pavia /Rio de Janeiro, Pont. U. Catol. /Puerto Rico U., Mayaguez /South Carolina U. /Tennessee U. /Vanderbilt U. /Wisconsin U., Madison

2005-04-01T23:59:59.000Z

135

Hot ion buildup and lifetime in LITE. Final report  

DOE Green Energy (OSTI)

An experimental investigation of hot ion buildup and lifetime in a small scale mirror device (LITE) is described. Hot ions were produced by 27 kV neutral beam injection into laser produced LiH plasmas and H plasmas produced by a washer gun. Hot H ion (12 kV) densities of approx. = 10/sup 12/ cm/sup -3/ were produced with the LiH target plasmas and densities an order of magnitude lower were produced with the washer gun target plasmas. Hot ion dominant plasmas were not achieved in LITE. The experimental measurements and subsequent analysis using numerical models of the plasma buildup indicate that in small, unshielded mirror plasmas, careful control must be maintained over the transient background gas density in the vicinity of the plasma surface. The hot ion lifetime in LITE was set by the transient cold neutral background resulting from the washer gun of reflux from the target plasma striking the adjacent surfaces.

Not Available

1978-09-01T23:59:59.000Z

136

Pressurized Water Reactor AgInCd Control Rod Lifetime  

Science Conference Proceedings (OSTI)

Swelling of the lower end tip of AgInCd (AIC) absorber rods is one of the lifetime limiting phenomena for PWR control rods. Understanding the relationship between swelling and accumulated fluence is crucial to predicting the service life of these components. This report presents the initial results and analyses from a control rod absorber research program led by the EPRI Fuel Reliability Program, in close collaboration with Westinghouse Electric Company and AREVA NP. The goals of the program are to chara...

2009-08-27T23:59:59.000Z

137

Lifetime statistics of quantum chaos studied by a multiscale analysis  

SciTech Connect

In a series of pump and probe experiments, we study the lifetime statistics of a quantum chaotic resonator when the number of open channels is greater than one. Our design embeds a stadium billiard into a two dimensional photonic crystal realized on a silicon-on-insulator substrate. We calculate resonances through a multiscale procedure that combines energy landscape analysis and wavelet transforms. Experimental data is found to follow the universal predictions arising from random matrix theory with an excellent level of agreement.

Di Falco, A.; Krauss, T. F. [School of Physics and Astronomy, University of St. Andrews, North Haugh, St. Andrews, KY16 9SS (United Kingdom); Fratalocchi, A. [PRIMALIGHT, Faculty of Electrical Engineering, Applied Mathematics and Computational Science, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Saudi Arabia)

2012-04-30T23:59:59.000Z

138

Lifetime of high-k gate dielectrics and analogy with strength of quasibrittle structures  

E-Print Network (OSTI)

The two-parameter Weibull distribution has been widely adopted to model the lifetime statistics of dielectric breakdown under constant voltage, but recent lifetime testing for high-k gate dielectrics has revealed a systematic ...

Le, Jia-Liang

139

The relationship of cognitive, emotional, and interpersonal factors to screening and health-promoting behaviors among sisters of breast cancer patients.  

E-Print Network (OSTI)

??While sisters of breast cancer patients are at increased risk for developing breast cancer due to their family cancer history and age, little research with… (more)

Hartman, Sheri Jacobs

2008-01-01T23:59:59.000Z

140

Risk-Related research at LBNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Risk-Related Research at Lawrence Berkeley National Laboratory Risk-Related Research at Lawrence Berkeley National Laboratory Table of Contents Human Exposure Assessment Cancer Risk Assessment Extrapolation of Cancer Risks from Animals to Humans Biodosimetry to Assess Human Genotoxicity from Mutagenic or Clastogenic Agents Transgenic Mouse Models Biological Effects of Complex Chemical Mixtures Physiologically-Based Pharmacokinetic (PBPK) and Cancer Models Electromagnetic Fields Risks of Ionizing Radiation in Space Risk-Based Remediation Strategy for Kesterson Reservoir Wetland Restoration and Sediment Quality Integrated, Risk-Based Environmental Clean-up SELECT: Environmental Decision-Making Software Introduction The Ernest Orlando Lawrence Berkeley National Laboratory (LBNL) conducts research to improve the scientific basis of risk assessment.

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Impact of Screening and Risk Factors for Local Recurrence and Survival After Conservative Surgery and Radiotherapy for Early Breast Cancer: Results From a Large Series With Long-Term Follow-Up  

SciTech Connect

Purpose: To investigate conventional prognostic factors for ipsilateral breast tumor recurrence (IBTR), distant metastasis (DM), and survival after breast-conserving therapy (BCT) in screen-detected and symptomatic cases on surveillance up to 25 years. Patients and Methods: A total of 1812 consecutive patients in three cohorts (1981-1989, 1990-1992, and 1993-1998) with T12N01M0 invasive breast cancer were treated with BCT (median follow-up, 14 years). Tumor type and grade were reviewed by a single pathologist. Hormone receptor status was measured by immunohistochemistry on tissue microarrays. A Cox proportional hazards model was used to assess independent prognostic variables for relapse and survival. Results: A total of 205 IBTR occurred, with 5-, 10-, 15-, and 20-year actuarial relapse rates of 4.5% (95% confidence interval [CI] 3.35-5.5%), 8.4% (95% CI 7.1-9.8%), 14.1% (95% CI 12.0-16%), and 17.4% (95% CI 14.5-20.2%). Number of nodes, young age, pathologic tumor size, and multifocality were significant factors for IBTR. Three hundred seventy-eight patients developed DM. The actuarial metastatic rate was 12% at 5 years and 17.9% at 10 years. Young age, number of positive nodes, pathologic tumor size, and tumor grade were significant factors for DM relapse. When conventional prognostic indices were taken into account screen-detected cancers showed no improvement in overall relapse or survival rate compared with symptomatic cases but did show a reduced risk of DM after IBTR. After 10 years IBTR relapse continued at a constant rate of 0.87% per annum. Conclusions: The Edinburgh BCT series has shown that screen-detected invasive breast cancers do not have significantly different clinical outcomes compared with symptomatic cases when pathologic risk factors are taken into account. This suggests that these patients be managed in a similar way.

Kunkler, Ian H., E-mail: I.Kunkler@ed.ac.uk [Edinburgh Cancer Centre, Western General Hospital, Edinburgh (United Kingdom); Kerr, Gillian R. [Edinburgh Cancer Centre, Western General Hospital, Edinburgh (United Kingdom); Thomas, Jeremy S. [Department of Pathology, Western General Hospital, Edinburgh (United Kingdom); Jack, Wilma J.L. [Edinburgh Breast Unit, Western General Hospital, Edinburgh (United Kingdom); Bartlett, John M.S. [Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh (United Kingdom); Pedersen, Hans C. [DAKO (Denmark); Cameron, David A. [Edinburgh Cancer Centre, Western General Hospital, Edinburgh (United Kingdom); Dixon, J. Michael; Chetty, Udi [Edinburgh Breast Unit, Western General Hospital, Edinburgh (United Kingdom)

2012-07-01T23:59:59.000Z

142

Using Remaining Battery lifetime information and Relaying to decrease Outage Probability of a Mobile  

E-Print Network (OSTI)

Using Remaining Battery lifetime information and Relaying to decrease Outage Probability is to demonstrate that by employing relaying and using the remaining battery lifetime information of Mobile is determined based on the remaining battery lifetime of the MT. We assume a linear relationship between

Singh, Suresh

143

From link dynamics to path lifetime and packet-length optimization in MANETs  

Science Conference Proceedings (OSTI)

We present an analytical framework and statistical models to accurately characterize the lifetime of a wireless link and multi-hop paths in mobile ad hoc networks (MANET). We show that the lifetimes of links and paths can be computed through a two-state ... Keywords: Analytical mobility modeling, Link dynamics, Markov model, Optimal information segmentation, Path lifetime

Xianren Wu; Hamid R. Sadjadpour; J. J. Garcia-Luna-Aceves

2009-07-01T23:59:59.000Z

144

Constrained multiple deployment problem in wireless sensor networks with guaranteed lifetimes  

Science Conference Proceedings (OSTI)

We aimed to deploy wireless sensor networks with guaranteed lifetimes for outdoor monitoring projects. The provision of a guaranteed lifetime has rarely been studied in previous deployment problems. The use of battery packs as the power source for sensors ... Keywords: Deployment problem, Guaranteed lifetime, Sensor network

Chun-Han Lin; Chung-Ta King; Ting-Yi Chen

2011-02-01T23:59:59.000Z

145

Chapter 16: Log-linear regression for Poisson counts Exposure to ionizing radiation is recognized as a cancer risk. In the United States, EPA  

E-Print Network (OSTI)

the past few decades. These estimates have been based largely on data for survivors of the atomic bombings of the Nagasaki and Hiroshima atomic bombs. -3-2-10 0-7 12-1 20-2 28-3 0-7 12-1 20-2 28-3 0-7 12-1 20-2 28-3 -3 to the incidence of cancer. The data dis- cussed below report the number of cancer deaths among the survivors

Bardsley, John

146

Recombination Lifetimes Using the RCPCD Technique: Comparison with Other Methods  

DOE Green Energy (OSTI)

The theory and operation of the resonance-coupled photoconductive decay (RCPCD) technique is described. Examples are presented of data measured on a wide variety of sample types. The RCPCD technique has been applied to a variety of wafer and thin-film materials. Using this technique, we can measure recombination lifetime over at least three decades of injection level. We can also measure relative values of minority-carrier mobility and diffusion length. By scanning the excitation wavelength, we can measure spectral response and photoconductive excitation spectra. Deep-level impurities have been detected by several variations of RCPCD.

Ahrenkiel, R.K.; Johnston, S.W.; Dashdorj, J.

2005-01-01T23:59:59.000Z

147

Electron Beam Polarization Measurement Using Touschek Lifetime Technique  

SciTech Connect

Electron beam loss due to intra-beam scattering, the Touschek effect, in a storage ring depends on the electron beam polarization. The polarization of an electron beam can be determined from the difference in the Touschek lifetime compared with an unpolarized beam. In this paper, we report on a systematic experimental procedure recently developed at Duke FEL laboratory to study the radiative polarization of a stored electron beam. Using this technique, we have successfully observed the radiative polarization build-up of an electron beam in the Duke storage ring, and determined the equilibrium degree of polarization and the time constant of the polarization build-up process.

Sun, Changchun; /Duke U., DFELL; Li, Jingyi; /Duke U., DFELL; Mikhailov, Stepan; /Duke U., DFELL; Popov, Victor; /Duke U., DFELL; Wu, Wenzhong; /Duke U., DFELL; Wu, Ying; /Duke U., DFELL; Chao, Alex; /SLAC; Xu, Hong-liang; /Hefei, NSRL; Zhang, Jian-feng; /Hefei, NSRL

2012-08-24T23:59:59.000Z

148

Determination of the b_s lifetime using hadronic decays  

SciTech Connect

The authors present a measurement of the B{sub s}{sup 0} meson lifetime using fully and partially reconstructed hadronic decays B{sub s}{sup 0} {yields} D{sub s}{sup -} {pi}{sup +}(X) followed by D{sub s}{sup -} {yields} {phi}{pi}{sup -}. The data sample was recorded with the CDF II detector at the Fermilab Tevatron and corresponds to an integrated luminosity of 1.3 fb{sup -1} from p{bar p} collisions at {radical}s = 1.96 TeV.

Deisher, A.J.; /LBL, Berkeley

2008-07-01T23:59:59.000Z

149

Lifetime measurements in the transitional nucleus {sup 138}Gd  

Science Conference Proceedings (OSTI)

Lifetime measurements have been made in the ground-state band of the transitional nucleus {sup 138}Gd from coincidence recoil-distance Doppler-shift data. {sup 138}Gd nuclei were produced using the {sup 106}Cd ({sup 36}Ar, 2p2n) reaction with a beam energy of 190 MeV. Reduced transition probabilities have been extracted from the lifetime data collected with the Koeln plunger placed at the target position of the JUROGAM-II array. The B(E2) values have been compared with predictions from X(5) critical-point calculations, which describe the phase transition between vibrational and axially symmetric nuclear shapes, as well as with IBM-1 calculations at the critical point. While the excitation energies in {sup 138}Gd are consistent with X(5) predictions, the large uncertainties associated with the measured B(E2) values cannot preclude vibrational and rotational contributions to the low-lying structure of {sup 138}Gd. Although experimental knowledge for the low-lying {gamma} and {beta}-vibrational bands in {sup 138}Gd is limited, potential-energy surface calculations suggest an increase in {gamma} softness in the ground-state band. In order to more fully account for the effects of {gamma} softness, the X(5) and IBM-1 calculations need to be extended to include the {gamma} degree of freedom for {sup 138}Gd.

Procter, M. G.; Cullen, D. M.; Taylor, M. J. [Schuster Laboratory, University of Manchester, Manchester, M13 9PL (United Kingdom); Ruotsalainen, P.; Grahn, T.; Greenlees, P. T.; Hauschild, K.; Jakobsson, U.; Jones, P. M.; Julin, R.; Juutinen, S.; Ketelhut, S.; Lopez-Martens, A.; Leino, M.; Nieminen, P.; Peura, P.; Rahkila, P.; Rinta-Antilla, S.; Sandzelius, M.; Saren, J. [Department of Physics, University of Jyvaeskylae, FIN-40014 Jyvaeskylae (Finland)

2011-08-15T23:59:59.000Z

150

Extending the lifetime of fuel cell based hybrid systems  

E-Print Network (OSTI)

Fuel cells are clean power sources that have much higher energy densities and lifetimes compared to batteries. However, fuel cells have limited load following capabilities and cannot be efficiently utilized if used in isolation. In this work, we consider a hybrid system where a fuel cell based hybrid power source is used to provide power to a DVFS processor. The hybrid power source consists of a room temperature fuel cell operating as the primary power source and a Li-ion battery (that has good load following capability) operating as the secondary source. Our goal is to develop polices to extend the lifetime of the fuel cell based hybrid system. First, we develop a charge based optimization framework which minimizes the charge loss of the hybrid system (and not the energy consumption of the DVFS processor). Next, we propose a new algorithm to minimize the charge loss by judiciously scaling the load current. We compare the performance of this algorithm with one that has been optimized for energy, and demonstrate its superiority. Finally, we evaluate the performance of the hybrid system under different system configurations and show how to determine the best combination of fuel cell size and battery capacity for a given embedded application.

Jianli Zhuo; Chaitali Chakrabarti; Naehyuck Chang; Sarma Vrudhula

2006-01-01T23:59:59.000Z

151

Geographic information system for Long Island: An epidemiologic systems approach to identify environmental breast cancer risks on Long Island. Phase 1  

Science Conference Proceedings (OSTI)

BNL is developing and implementing the project ``Geographic Information System (GIS) for Long Island`` to address the potential relationship of environmental and occupational exposures to breast cancer etiology on Long Island. The project is divided into two major phases: The four month-feasibility project (Phase 1), and the major development and implementation project (Phase 2). This report summarizes the work completed in the four month Phase 1 Project, ``Feasibility of a Geographic Information System for Long Island.`` It provides the baseline information needed to further define and prioritize the scope of work for subsequent tasks. Phase 2 will build upon this foundation to develop an operational GIS for the Long Island Breast Cancer Study Project (LIBCSP).

Barancik, J.I.; Kramer, C.F.; Thode, H.C. Jr.

1995-12-01T23:59:59.000Z

152

Risk Prioritization  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Quality Managers Quality Managers Software Quality Assurance Subcommittee Reference Document SQAS21.01.00 - 1999 Software Risk Management A Practical Guide February, 2000 Abstract This document is a practical guide for integrating software risk management into a software project. The purpose of Risk Management is to identify, assess and control project risks. Identified risks are analyzed to determine their potential impact and likelihood of occurrence. Risk Management Plans are developed to document the project's approach to risk management, risks, and decisions made about what should be done with each risk. Risks and risk actions are then tracked to closure. Software Risk Management: A Practical Guide SQAS21.01.00 Acknowledgments This document was prepared for the Department of Energy (DOE) by a Working Group of the DOE

153

THE LIFETIME AND POWERS OF FR IIs IN GALAXY CLUSTERS  

Science Conference Proceedings (OSTI)

We have identified and studied a sample of 151 FR IIs found in brightest cluster galaxies (BCGs) in the MaxBCG cluster catalog with data from FIRST and NVSS. We have compared the radio luminosities and projected lengths of these FR IIs to the projected length distribution of a range of mock catalogs generated by an FR II model and estimate the FR II lifetime to be 1.9 Multiplication-Sign 10{sup 8} yr. The uncertainty in the lifetime calculation is a factor of two, primarily due to uncertainties in the intracluster medium (ICM) density and the FR II axial ratio. We furthermore measure the jet power distribution of FR IIs in BCGs and find that it is well described by a log-normal distribution with a median power of 1.1 Multiplication-Sign 10{sup 37} W and a coefficient of variation of 2.2. These jet powers are nearly linearly related to the observed luminosities, and this relation is steeper than many other estimates, although it is dependent on the jet model. We investigate correlations between FR II and cluster properties and find that galaxy luminosity is correlated with jet power. This implies that jet power is also correlated with black hole mass, as the stellar luminosity of a BCG should be a good proxy for its spheroid mass and therefore the black hole mass. Jet power, however, is not correlated with cluster richness, nor is FR II lifetime strongly correlated with any cluster properties. We calculate the enthalpy of the lobes to examine the impact of the FR IIs on the ICM and find that heating due to adiabatic expansion is too small to offset radiative cooling by a factor of at least six. In contrast, the jet power is approximately an order of magnitude larger than required to counteract cooling. We conclude that if feedback from FR IIs offsets cooling of the ICM, then heating must be primarily due to another mechanism associated with FR II expansion.

Antognini, Joe; Bird, Jonathan; Martini, Paul, E-mail: antognini@astronomy.ohio-state.edu, E-mail: bird@astronomy.ohio-state.edu, E-mail: martini@astronomy.ohio-state.edu [Department of Astronomy, Ohio State University, 140 W 18th Avenue, Columbus, OH 43210 (United States)

2012-09-10T23:59:59.000Z

154

Enhancement of the steady state minority carrier lifetime in HgCdTe photodiode using ECR plasma hydrogenation  

Science Conference Proceedings (OSTI)

Keywords: HgCdTe, diffusion length, field effect transistor, hydrogenation, lifetime, mobility, photodiode

Han Jung; Hee Chul Lee; Choong-Ki Kim

1996-08-01T23:59:59.000Z

155

Microstructure, morphology and lifetime of armored bubbles exposed to surfactants  

E-Print Network (OSTI)

We report the behavior of particle-stabilized bubbles (armored bubbles) when exposed to various classes and concentrations of surfactants. The bubbles are non-spherical due to the jamming of the particles on the interface and are stable to dissolution prior to the addition of surfactant. We find that the dissolving bubbles exhibit distinct morphological, microstructural, and lifetime changes, which correlate with the concentration of surfactant employed. For low concentrations of surfactant an armored bubble remains non-spherical while dissolving, while for concentrations close to and above the surfactant CMC a bubble reverts to a spherical shape before dissolving. We propose a microstructural interpretation, supported by our experimental observations of particle dynamics on the bubble interface, that recognizes the role of interfacial jamming and stresses in particle stabilization and surfactant-mediated destabilization of armored bubbles.

Anand Bala Subramaniam; Cecile Mejean; Manouk Abkarian; Howard A. Stone

2006-02-16T23:59:59.000Z

156

Measurements of ultracold neutron lifetimes in solid deuterium  

E-Print Network (OSTI)

We present the first measurements of the survival time of ultracold neutrons (UCNs) in solid deuterium SD2. This critical parameter provides a fundamental limitation to the effectiveness of superthermal UCN sources that utilize solid ortho-deuterium as the source material. Superthermal UCN sources offer orders of magnitude improvement in the available densities of UCNs, and are of great importance to fundamental particle-physics experiments such as searches for a static electric dipole moment and lifetime measurements of the free neutron. These measurements are performed utilizing a SD2 source coupled to a spallation source of neutrons, providing a demonstration of UCN production in this geometry and permitting systematic studies of the influence of thermal up-scatter and contamination with para-deuterium on the UCN survival time.

C. L. Morris; J. M. Anaya; T. J. Bowles; B. W. Filippone; P. Geltenbort; R. E. Hill; M. Hino; S. Hoedl; G. E. Hogan; T. M. Ito; T. Kawai; K. Kirch; S. K. Lamoreaux; C. -Y. Liu; M. Makela; L. J. Marek; J. W. Martin; R. N. Mortensen; A. Pichlmaier; A. Saunders; S. J. Seestrom; D. Smith; W. Teasdale; B. Tipton; M. Utsuro; A. R. Young; J. Yuan

2001-09-27T23:59:59.000Z

157

Extending lifetime of portable systems by battery scheduling  

E-Print Network (OSTI)

Multi-battery power supplies are becoming popular in electronic appliances of the latest generations, due to economical and manufacturing constraints. Unfortunately, a partitioned battery subsystem is not able to deliver the same amount of charge as a monolithic battery with the same total capacity. In this paper, we de ne the concept of battery scheduling, we investigate policies for solving the problem of optimal charge delivery, and we study the relationship of such policies with di erent con gurations of the battery subsystem. Results, obtained for di erent workloads, demonstrate that the choice of the proper scheduling can make, in the best case, system lifetime as close as 1 % of that guaranteed by a monolithic battery of equal capacity. 1

L. Benini; G. Castelli Z; A. Macii Z

2001-01-01T23:59:59.000Z

158

Refinement of risk analysis procedures for trichloroethylene through the use of Monte Carlo method in conjunction with physiologically based pharmacokinetic modeling. Master's thesis  

Science Conference Proceedings (OSTI)

This study refines risk analysis procedures for trichloroethylene (TCE) using a physiologically based pharmacokinetic (PBPK) model in conjunction with the Monte Carlo method. The Monte Carlo method is used to generate random sets of model parameters, based on the mean, variance, and distribution types. The procedure generates a range of exposure values for human excess lifetime cancer risk of lxl0 (exp-6), based on the upper and lower bounds and the mean of a 95% confidence interval. Risk ranges were produced for both ingestion and inhalation exposures. Results are presented in a graphical format to reduce reliance on qualitative discussions of uncertainty. A sensitivity analysis of the model was also performed. This method produced acceptable TCE exposures, for total amount TCE metabolized, greater than the Environmental Protection Agency's (EPA) by a factor of 23 for inhalation and a factor of 1.6 for ingestion. Sensitive parameters identified were the elimination rate constant, alveolar ventilation rate, and cardiac output. This procedure quantifies the uncertainty related to natural variations in parameter values. Its incorporation into risk assessment could be used to promulgate, and better present, more realistic standards.... Risk analysis, Physiologically based pharmacokinetics, Pbpk, Trichloroethylene, Monte carlo method.

Cronin, W.J.; Oswald, E.J.

1993-09-01T23:59:59.000Z

159

Long-Term Follow-Up of a Prospective Trial of Trimodality Therapy of Weekly Paclitaxel, Radiation, and Androgen Deprivation in High-Risk Prostate Cancer With or Without Prior Prostatectomy  

SciTech Connect

Purpose: Weekly paclitaxel, concurrent radiation, and androgen deprivation (ADT) were evaluated in patients with high-risk prostate cancer (PC) with or without prior prostatectomy (RP). Methods and Materials: Eligible post-RP patients included: pathological T3 disease, or rising prostate-specific antigen (PSA) {>=}0.5 ng/mL post-RP. Eligible locally advanced PC (LAPC) patients included: 1) cT2b-4N0N+, M0; 2) Gleason score (GS) 8-10; 3) GS 7 + PSA 10-20 ng/mL; or 4) PSA 20-150 ng/mL. Treatment included ADT (4 or 24 months), weekly paclitaxel (40, 50, or 60 mg/m{sup 2}/wk), and pelvic radiation therapy (total dose: RP = 64.8 Gy; LAPC = 70.2 Gy). Results: Fifty-nine patients were enrolled (LAPC, n = 29; RP, n = 30; ADT 4 months, n = 29; 24 months, n = 30; whites n = 29, African Americans [AA], n = 28). Baseline characteristics (median [range]) were: age 67 (45-86 years), PSA 5.9 (0.1-92.1 ng/mL), GS 8 (6-9). At escalating doses of paclitaxel, 99%, 98%, and 95% of doses were given with radiation and ADT, respectively, with dose modifications required primarily in RP patients. No acute Grade 4 toxicities occurred. Grade 3 toxicities were diarrhea 15%, urinary urgency/incontinence 10%, tenesmus 5%, and leukopenia 3%. Median follow-up was 75.3 months (95% CI: 66.8-82.3). Biochemical progression occurred in 24 (41%) patients and clinical progression in 11 (19%) patients. The 5- and 7-year OS rates were 83% and 67%. There were no differences in OS between RP and LAPC, 4- and 24-month ADT, white and AA patient categories. Conclusions: In addition to LAPC, to our knowledge, this is the first study to evaluate concurrent chemoradiation with ADT in high-risk RP patients. With a median follow-up of 75.3 months, this trial also represents the longest follow-up of patients treated with taxane-based chemotherapy with EBRT in high-risk prostate cancer. Concurrent ADT, radiation, and weekly paclitaxel at 40 mg/m{sup 2}/week in RP patients and 60 mg/m{sup 2}/week in LAPC patients is feasible and well-tolerated.

Hussain, Arif, E-mail: ahussain@som.umaryland.edu [University of Maryland Greenebaum Cancer Center, Baltimore, MD (United States); Department of Medicine, University of Maryland School of Medicine, Baltimore, MD (United States); Baltimore VA Medical Center, Baltimore, MD (United States); Wu, Yin [Department of Medicine, University of Maryland School of Medicine, Baltimore, MD (United States); Mirmiran, Alireza [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD (United States); DiBiase, Steven [Cooper University Hospital, Camden, NJ (United States); Goloubeva, Olga [University of Maryland Greenebaum Cancer Center, Baltimore, MD (United States); Bridges, Benjamin [University of Maryland Greenebaum Cancer Center, Baltimore, MD (United States); Department of Medicine, University of Maryland School of Medicine, Baltimore, MD (United States); Mannuel, Heather [University of Maryland Greenebaum Cancer Center, Baltimore, MD (United States); Department of Medicine, University of Maryland School of Medicine, Baltimore, MD (United States); Baltimore VA Medical Center, Baltimore, MD (United States); Engstrom, Christine [Baltimore VA Medical Center, Baltimore, MD (United States); Dawson, Nancy [Lombardi Cancer Center, Georgetown University, Washington, D.C (United States); Amin, Pradip; Kwok, Young [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD (United States)

2012-01-01T23:59:59.000Z

160

Steps to Preventing Colon Cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

watch out for belly fat. One of the key findings from the CUP report is that excess body fat is linked to increased risk of colorectal cancer. The report also concludes that...

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Effects of Neutron Irradiation on Positron Lifetime and Micro-Vicker ...  

Science Conference Proceedings (OSTI)

Aug 1, 1999 ... Effects of Neutron Irradiation on Positron Lifetime and Micro-Vicker Hardness of Fe-Cu Model Alloys and Reactor Pressure Vessel Steel

162

LIFETIME PREDICTION FOR MODEL 9975 O-RINGS IN KAMS  

SciTech Connect

The Savannah River Site (SRS) is currently storing plutonium materials in the K-Area Materials Storage (KAMS) facility. The materials are packaged per the DOE 3013 Standard and transported and stored in KAMS in Model 9975 shipping packages, which include double containment vessels sealed with dual O-rings made of Parker Seals compound V0835-75 (based on Viton{reg_sign} GLT). The outer O-ring of each containment vessel is credited for leaktight containment per ANSI N14.5. O-ring service life depends on many factors, including the failure criterion, environmental conditions, overall design, fabrication quality and assembly practices. A preliminary life prediction model has been developed for the V0835-75 O-rings in KAMS. The conservative model is based primarily on long-term compression stress relaxation (CSR) experiments and Arrhenius accelerated-aging methodology. For model development purposes, seal lifetime is defined as a 90% loss of measurable sealing force. Thus far, CSR experiments have only reached this target level of degradation at temperatures {ge} 300 F. At lower temperatures, relaxation values are more tolerable. Using time-temperature superposition principles, the conservative model predicts a service life of approximately 20-25 years at a constant seal temperature of 175 F. This represents a maximum payload package at a constant ambient temperature of 104 F, the highest recorded in KAMS to date. This is considered a highly conservative value as such ambient temperatures are only reached on occasion and for short durations. The presence of fiberboard in the package minimizes the impact of such temperature swings, with many hours to several days required for seal temperatures to respond proportionately. At 85 F ambient, a more realistic but still conservative value, bounding seal temperatures are reduced to {approx}158 F, with an estimated seal lifetime of {approx}35-45 years. The actual service life for O-rings in a maximum wattage package likely lies higher than the estimates due to the conservative assumptions used for the model. For lower heat loads at similar ambient temperatures, seal lifetime is further increased. The preliminary model is based on several assumptions that require validation with additional experiments and longer exposures at more realistic conditions. The assumption of constant exposure at peak temperature is believed to be conservative. Cumulative damage at more realistic conditions will likely be less severe but is more difficult to assess based on available data. Arrhenius aging behavior is expected, but non-Arrhenius behavior is possible. Validation of Arrhenius behavior is ideally determined from longer tests at temperatures closer to actual service conditions. CSR experiments will therefore continue at lower temperatures to validate the model. Ultrasensitive oxygen consumption analysis has been shown to be useful in identifying non-Arrhenius behavior within reasonable test periods. Therefore, additional experiments are recommended and planned to validate the model.

Hoffman, E.; Skidmore, E.

2009-11-24T23:59:59.000Z

163

WE?A?213AB?01: Second Cancers from Radiation Therapy Procedures  

Science Conference Proceedings (OSTI)

Second Cancers are the most common late effect among long?term cancer survivors. Radiation has been a known risk factor for cancer induction based on atomic bomb survivor follow?up. Over the last few decades

S Kry; R Howell

2012-01-01T23:59:59.000Z

164

Accelerated lifetime estimation of thermosonic Cu ball bonds on Al metallization  

Science Conference Proceedings (OSTI)

In this study a fast mechanical shear fatigue test technique for the quality assessment of thermosonic ball bonded interconnects was developed to estimate their lifetime behavior. The micro-interconnects were subjected to cyclic shear stress using a ... Keywords: Cu/Al Ball bond, Fatigue, Fracture mechanics, Lifetime, Microelectronic interconnects

A. Lassnig, W. Trasischker, G. Khatibi, B. Weiss, M. Nelhiebel, R. Pelzer

2013-06-01T23:59:59.000Z

165

Extending the lifetime of media recorders constrained by battery and flash memory size  

Science Conference Proceedings (OSTI)

The lifetime of a stand-alone media recorder is a function of both the battery size and flash memory size. In this paper, we present a power management framework for media recorders that significantly enhances their lifetime while minimizing the flash ... Keywords: dynamic voltage scaling, multimedia, passive voltage scaling

Younghyun Kim; Youngjin Cho; Naehyuck Chang; Chaitali Chakrabarti; Nam Ik Cho

2008-08-01T23:59:59.000Z

166

A Proactive Wearout Recovery Approach for Exploiting Microarchitectural Redundancy to Extend Cache SRAM Lifetime  

Science Conference Proceedings (OSTI)

Microarchitectural redundancy has been proposed as a means of improving chip lifetime reliability. It is typically used in a reactive way, allowing chips to maintain operability in the presence of failures by detecting and isolating, correcting, and/or ... Keywords: lifetime reliability, microarchitectural redundancy, proactive approach, wearout recovery

Jeonghee Shin; Victor Zyuban; Pradip Bose; Timothy M. Pinkston

2008-06-01T23:59:59.000Z

167

Deployment guidelines for achieving maximum lifetime and avoiding energy holes in sensor network  

Science Conference Proceedings (OSTI)

The demand for maximum network lifetime in many mission-critical applications of wireless sensor networks motivates the great significance to deploy as few sensors as possible to achieve the expected network performance. In this paper, we first characterize ... Keywords: Adjustable transmission range, Energy-hole, Network lifetime, Node deployment, Wireless sensor network

Anfeng Liu; Xin Jin; Guohua Cui; Zhigang Chen

2013-05-01T23:59:59.000Z

168

Optimizing lifetime for continuous data aggregation with precision guarantees in wireless sensor networks  

Science Conference Proceedings (OSTI)

This paper exploits the tradeoff between data quality and energy consumption to extend the lifetime of wireless sensor networks. To obtain an aggregate form of sensor data with precision guarantees, the precision constraint is partitioned and allocated ... Keywords: data accuracy, data aggregation, energy efficiency, network lifetime, sensor network

Xueyan Tang; Jianliang Xu

2008-08-01T23:59:59.000Z

169

Long-Term Results of a Prospective, Phase II Study of Long-Term Androgen Ablation, Pelvic Radiotherapy, Brachytherapy Boost, and Adjuvant Docetaxel in Patients With High-Risk Prostate Cancer  

Science Conference Proceedings (OSTI)

Purpose: We report the long-term results of a prospective, Phase II study of long-term androgen deprivation (AD), pelvic radiotherapy (EBRT), permanent transperineal prostate brachytherapy boost (PB), and adjuvant docetaxel in patients with high-risk prostate cancer. Methods and Materials: Eligibility included biopsy-proven prostate adenocarcinoma with the following: prostate-specific antigen (PSA) > 20 ng/ml; or Gleason score of 7 and a PSA >10 ng/ml; or any Gleason score of 8 to 10; or stage T2b to T3 irrespective of Gleason score or PSA. Treatment consisted of 45 Gy of pelvic EBRT, followed 1 month later by PB with either iodine-125 or Pd-103. One month after PB, patients received three cycles of docetaxel chemotherapy (35 mg/m{sup 2} per week, Days 1, 8, and 15 every 28 days). All patients received 2 years of AD. Biochemical failure was defined as per the Phoenix definition (PSA nadir + 2). Results: From August 2000 to March 2004, 42 patients were enrolled. The median overall and active follow-ups were 5.6 years (range, 0.9-7.8 years) and 6.3 years (range, 4-7.8 years), respectively. Grade 2 and 3 acute genitourinary (GU) and gastrointestinal (GI) toxicities were 50.0% and 14.2%, respectively, with no Grade 4 toxicities noted. Grade 3 and 4 acute hematologic toxicities were 19% and 2.4%, respectively. Of the patients, 85.7% were able to complete the planned multimodality treatment. The 5- and 7-year actuarial freedom from biochemical failures rates were 89.6% and 86.5%, and corresponding rates for disease-free survival were 76.2% and 70.4%, respectively. The 5- and 7-year actuarial overall survival rates were 83.3% and 80.1%, respectively. The 5- and 7-year actuarial rates of late Grade 2 GI/GU toxicity (no Grade 3-5) was 7.7%. Conclusions: The trimodality approach of using 2 years of AD, external radiation, brachytherapy, and upfront docetaxel in high-risk prostate cancer is well tolerated, produces encouraging long-term results, and should be validated in a multi-institutional setting.

DiBiase, Steven J., E-mail: sdibiase@dvullc.com [Department of Radiation Oncology, Robert Wood Johnson School of Medicine and Cooper University Hospital, Camden, NJ (United States); Hussain, Arif [Division of Hematology and Oncology, University of Maryland School of Medicine, Baltimore, MD (United States); Kataria, Ritesh; Amin, Pradip; Bassi, Sunakshi [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD (United States); Dawson, Nancy [Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC (United States); Kwok, Young [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD (United States)

2011-11-01T23:59:59.000Z

170

Patient-specific radiation dose and cancer risk estimation in CT: Part I. Development and validation of a Monte Carlo program  

SciTech Connect

Purpose: Radiation-dose awareness and optimization in CT can greatly benefit from a dose-reporting system that provides dose and risk estimates specific to each patient and each CT examination. As the first step toward patient-specific dose and risk estimation, this article aimed to develop a method for accurately assessing radiation dose from CT examinations. Methods: A Monte Carlo program was developed to model a CT system (LightSpeed VCT, GE Healthcare). The geometry of the system, the energy spectra of the x-ray source, the three-dimensional geometry of the bowtie filters, and the trajectories of source motions during axial and helical scans were explicitly modeled. To validate the accuracy of the program, a cylindrical phantom was built to enable dose measurements at seven different radial distances from its central axis. Simulated radial dose distributions in the cylindrical phantom were validated against ion chamber measurements for single axial scans at all combinations of tube potential and bowtie filter settings. The accuracy of the program was further validated using two anthropomorphic phantoms (a pediatric one-year-old phantom and an adult female phantom). Computer models of the two phantoms were created based on their CT data and were voxelized for input into the Monte Carlo program. Simulated dose at various organ locations was compared against measurements made with thermoluminescent dosimetry chips for both single axial and helical scans. Results: For the cylindrical phantom, simulations differed from measurements by -4.8% to 2.2%. For the two anthropomorphic phantoms, the discrepancies between simulations and measurements ranged between (-8.1%, 8.1%) and (-17.2%, 13.0%) for the single axial scans and the helical scans, respectively. Conclusions: The authors developed an accurate Monte Carlo program for assessing radiation dose from CT examinations. When combined with computer models of actual patients, the program can provide accurate dose estimates for specific patients.

Li Xiang; Samei, Ehsan; Segars, W. Paul; Sturgeon, Gregory M.; Colsher, James G.; Toncheva, Greta; Yoshizumi, Terry T.; Frush, Donald P. [Medical Physics Graduate Program, Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Medical Physics Graduate Program, Department of Physics, and Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States) and Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Duke Radiation Dosimetry Laboratory, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Duke Radiation Dosimetry Laboratory, Department of Radiology, Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 (United States); Division of Pediatric Radiology, Department of Radiology, Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27710 (United States)

2011-01-15T23:59:59.000Z

171

HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer  

SciTech Connect

Purpose: We investigated potential associations between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and overall survival in US patients with non-small cell lung cancer (NSCLC). Methods and Materials: Using available genomic DNA samples from 224 patients with NSCLC treated with definitive radio(chemo)therapy, we genotyped 2 SNPs of HSPB1 (NCBI SNP nos. rs2868370 and rs2868371). We used both Kaplan-Meier cumulative probability and Cox proportional hazards analyses to evaluate the effect of HSPB1 genotypes on survival. Results: Our cohort consisted of 117 men and 107 women, mostly white (79.5%), with a median age of 70 years. The median radiation dose was 66 Gy (range, 63-87.5 Gy), and 183 patients (82%) received concurrent platinum-based chemotherapy. The most common genotype of the rs2868371 SNP was CC (61%). Univariate and multivariate analyses showed that this genotype was associated with poorer survival than CG and GG genotypes (univariate hazard ratio [HR] = 1.39, 95% confidence interval [CI], 1.02-1.90; P=.037; multivariate HR = 1.39; 95% CI, 1.01-1.92; P=.045). Conclusions: Our results showed that the CC genotype of HSPB1 rs2868371 was associated with poorer overall survival in patients with NSCLC after radio(chemo)therapy, findings that contradict those of a previous study of Chinese patients. Validation of our findings with larger numbers of similar patients is needed, as are mechanical and clinical studies to determine the mechanism underlying these associations.

Xu Ting [Institute of Clinical Pharmacology, Central South University, Changsha, Hunan (China) [Institute of Clinical Pharmacology, Central South University, Changsha, Hunan (China); Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei Qingyi [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lopez Guerra, Jose Luis [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States) [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Instituto Madrileno de Oncologia/Grupo IMO, Madrid (Spain); Wang Lie; Liu Zhensheng [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gomez, Daniel; O'Reilly, Michael; Lin, Steven Hsesheng [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang Yan [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Levy, Lawrence B. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhou Honghao [Institute of Clinical Pharmacology, Central South University, Changsha, Hunan (China)] [Institute of Clinical Pharmacology, Central South University, Changsha, Hunan (China); Liao Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2012-10-01T23:59:59.000Z

172

Carbon Sequestration Risks and Risk Management  

NLE Websites -- All DOE Office Websites (Extended Search)

Carbon Sequestration Risks and Risk Management Title Carbon Sequestration Risks and Risk Management Publication Type Report Year of Publication 2008 Authors Price, Phillip N.,...

173

Optimal Reversible Annuities to Minimize the Probability of Lifetime Ruin  

E-Print Network (OSTI)

We find the minimum probability of lifetime ruin of an investor who can invest in a market with a risky and a riskless asset and who can purchase a reversible life annuity. The surrender charge of a life annuity is a proportion of its value. Ruin occurs when the total of the value of the risky and riskless assets and the surrender value of the life annuity reaches zero. We find the optimal investment strategy and optimal annuity purchase and surrender strategies in two situations: (i) the value of the risky and riskless assets is allowed to be negative, with the imputed surrender value of the life annuity keeping the total positive; or (ii) the value of the risky and riskless assets is required to be non-negative. In the first case, although the individual has the flexiblity to buy or sell at any time, we find that the individual will not buy a life annuity unless she can cover all her consumption via the annuity and she will never sell her annuity. In the second case, the individual surrenders just enough annuity income to keep her total assets positive. However, in this second case, the individual’s annuity purchasing strategy depends on the size of the proportional surrender charge. When the charge is large enough, the individual will not buy a life annuity unless she can cover all her consumption, the so-called safe level. When the charge is small enough, the individual will buy a life annuity at a wealth lower than this safe level. Key words. Life annuities, retirement, optimal investment, stochastic control, freeboundary problem 1

Ting Wang; Virginia R. Young

2009-01-01T23:59:59.000Z

174

Los Alamos National Laboratory W76 Pit Tube Lifetime Study  

SciTech Connect

A metallurgical study was requested as part of the Los Alamos National Laboratory (LANL) W76-1 life-extension program (LEP) involving a lifetime analysis of type 304 stainless steel pit tubes subject to repeat bending loads during assembly and disassembly operations at BWXT/Pantex. This initial test phase was completed during the calendar years of 2004-2006 and the report not issued until additional recommended tests could be performed. These tests have not been funded to this date and therefore this report is considered final. Tubes were reportedly fabricated according to Rocky Flats specification P14548 - Seamless Type 304 VIM/VAR Stainless Steel Tubing. Tube diameter was specified as 0.125 inches and wall thickness as 0.028 inches. A heat treat condition is not specified and the hardness range specification can be characteristic of both 1/8 and 1/4 hard conditions. Properties of all tubes tested were within specification. Metallographic analysis could not conclusively determine a specified limit to number of bends allowable. A statistical analysis suggests a range of 5-7 bends with a 99.95% confidence limit. See the 'Statistical Analysis' section of this report. The initial phase of this study involved two separate sets of test specimens. The first group was part of an investigation originating in the ESA-GTS [now Gas Transfer Systems (W-7) Group]. After the bend cycle test parameters were chosen (all three required bends subjected to the same amount of bend cycles) and the tubes bent, the investigation was transferred to Terri Abeln (Metallurgical Science and Engineering) for analysis. Subsequently, another limited quantity of tubes became available for testing and were cycled with the same bending fixture, but with different test parameters determined by T. Abeln.

Abeln, Terri G. [Los Alamos National Laboratory

2012-04-25T23:59:59.000Z

175

First working group meeting on the minority carrier diffusion length/lifetime measurement: Results of the round robin lifetime/diffusion length tests  

DOE Green Energy (OSTI)

As was noted in the cover letter that accompanied the samples, the eleven bare silicon samples were from various manufacturers. Table I lists the codes for the samples and the manufacturer of each sample. It also notes if the sample was single or poly-crystalline. The samples had been polished on one side before being sent out for measurements, but no further processing was done. The participants of the study were asked to measure either the lifetime or diffusion length of each of the samples using their standard procedure. Table II shows the experimental conditions used by the groups who measured diffusion length. All the diffusion length measurements were performed using the Surface Photovoltage method (SPV). Table M shows the experimental conditions for the lifetime measurements. All the lifetime measurements were made using the Photoconductance Decay method (PCD) under low level injection. These tables show the diameter of the spot size used during the measurement (the effective sampling area), the locations where measurements were taken, and the number of measurements taken at each location. Table N shows the results of the measurements. The table is divided into diffusion length and lifetime measurements for each sample. The values listed are the average values reported by each group. One of the immediate artifacts seen in the data is the large variation in the lifetime measurements. The values from MIT and Mobil are generally close. However, the measurements from NCSU are typically an order of magnitude lower.

Cudzinovic, M.; Sopori, B. [comp.

1995-11-01T23:59:59.000Z

176

New Tool Quantitatively Maps Minority-Carrier Lifetime of Multicrystalline Silicon Bricks (Fact Sheet)  

DOE Green Energy (OSTI)

NREL's new imaging tool could provide manufacturers with insight on their processes. Scientists at the National Renewable Energy Laboratory (NREL) have used capabilities within the Process Development and Integration Laboratory (PDIL) to generate quantitative minority-carrier lifetime maps of multicrystalline silicon (mc-Si) bricks. This feat has been accomplished by using the PDIL's photoluminescence (PL) imaging system in conjunction with transient lifetime measurements obtained using a custom NREL-designed resonance-coupled photoconductive decay (RCPCD) system. PL imaging can obtain rapid high-resolution images that provide a qualitative assessment of the material lifetime-with the lifetime proportional to the pixel intensity. In contrast, the RCPCD technique provides a fast quantitative measure of the lifetime with a lower resolution and penetrates millimeters into the mc-Si brick, providing information on bulk lifetimes and material quality. This technique contrasts with commercially available minority-carrier lifetime mapping systems that use microwave conductivity measurements. Such measurements are dominated by surface recombination and lack information on the material quality within the bulk of the brick. By combining these two complementary techniques, we obtain high-resolution lifetime maps at very fast data acquisition times-attributes necessary for a production-based diagnostic tool. These bulk lifetime measurements provide manufacturers with invaluable feedback on their silicon ingot casting processes. NREL has been applying the PL images of lifetime in mc-Si bricks in collaboration with a U.S. photovoltaic industry partner through Recovery Act Funded Project ARRA T24. NREL developed a new tool to quantitatively map minority-carrier lifetime of multicrystalline silicon bricks by using photoluminescence imaging in conjunction with resonance-coupled photoconductive decay measurements. Researchers are not hindered by surface recombination and can look deeper into the material to map bulk lifetimes. The tool is being applied to silicon bricks in a project collaborating with a U.S. photovoltaic industry partner. Photovoltaic manufacturers can use the NREL tool to obtain valuable feedback on their silicon ingot casting processes.

Not Available

2011-11-01T23:59:59.000Z

177

Increasing network lifetime in an energy-constrained wireless sensor network  

Science Conference Proceedings (OSTI)

Energy in wireless sensor networks is a scarce resource, therefore an energy-efficient mechanism is required to increase the network lifetime. In this paper, we study the problem of optimal power allocation, taking into account the estimation of the ...

Said El Abdellaoui; Mérouane Debbah; Youssef Fakhri; Driss Aboutajdine

2013-03-01T23:59:59.000Z

178

Modeling Minority-Carrier Lifetime Techniques That Use Transient Excess-Carrier Decay: Preprint  

DOE Green Energy (OSTI)

Lifetime spectroscopy is a valuable tool for the characterization of PV materials. This paper combines modeling and experimental results to illustrate the injection-level dependent response of three transient excess-carrier decay techniques.

Johnston, S. W.; Berman, G. M.; Ahrenkiel, R. K.

2008-05-01T23:59:59.000Z

179

New Accelerated Testing and Lifetime Modeling Methods Promise Faster Development of More Durable MEAs  

DOE Green Energy (OSTI)

For the successful commercialization of fuel cell technology, it is imperative that membrane electrode assembly (MEA) durability is understood and quantified. MEA lifetimes of 40,000 hours remain a key target for stationary power applications. Since it is impractical to wait 40,000 hours for durability results, it is critical to learn as much information as possible in as short a time period as possible to determine if an MEA sample will survive past its lifetime target. Consequently, 3M has utilized accelerated testing and statistical lifetime modeling tools to develop a methodology for evaluating MEA lifetime. Construction and implementation of a multi-cell test stand have allowed for multiple accelerated tests and stronger statistical data for learning about durability.

Pierpont, D. M.; Hicks, M. T.; Turner, P. L.; Watschke, T. M.

2005-11-01T23:59:59.000Z

180

Lifetime measurements of high-lying short lived states in {sup 69}As  

Science Conference Proceedings (OSTI)

Lifetimes of high-spin states in {sup 69}As have been measured using Doppler shift attenuation technique with the GASP and RFD setup. The determined transition probabilities indicate large deformation associated with some rotational bands in this nucleus.

Matejska-Minda, M.; Bednarczyk, P.; Fornal, B.; Ciemala, M.; Kmiecik, M.; Krzysiek, M.; Maj, A.; Meczynski, W.; Myalski, S.; Styczen, J.; Zieblinski, M.; Angelis, G. de; Huyuk, T.; Michelagnoli, C.; Sahin, E.; Aydin, S.; Farnea, E.; Menegazzo, R.; Recchia, F.; Ur, C. A. [Institute of Nuclear Physics, Polish Academy of Sciences, Krakow (Poland); INFN, Laboratori Nazionali di Legnaro, Legnaro (Italy); Dipartimento di Fisica e INFN Padova (Italy); Dipartimento di Fisica e INFN Milano (Italy); Heavy Ion Laboratory, University of Warsaw (Poland); University of York (United Kingdom); and others

2012-10-20T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

FISSION YIELDS AND LIFETIMES FOR MUON INDUCED FISSION IN 235U AND 238U  

E-Print Network (OSTI)

University of California. FISSION YIELDS AL\\JD LIFETIMES FORfor his assistance in the fission chamber calibrations andCl8 (1978) 1452. Table 1 Fission yields yf Nucleus 23su 23Su

Ahmad, S.

2012-01-01T23:59:59.000Z

182

Theory of SEI Formation in Rechargeable Batteries: Capacity Fade, Accelerated Aging and Lifetime Prediction  

E-Print Network (OSTI)

Cycle life is critically important in applications of rechargeable batteries, but lifetime prediction is mostly based on empirical trends, rather than mathematical models. In practical lithium-ion batteries, capacity fade ...

Pinson, Matthew Bede

183

The Needs of a Lifetime: The Search for Security, 1865-1914  

E-Print Network (OSTI)

age in an era without Social Security. v Table of Contentsthem for mortgages or securities, or to secure various formsLifetime: The Search for Security, 1865-1914 A Dissertation

Yang, Tony

2009-01-01T23:59:59.000Z

184

Lifetime reliability assessment with aging information from low-level sensors  

Science Conference Proceedings (OSTI)

Aggressive technology scaling has led Integrated Circuits (ICs) suffer from ever-increasing wearout effects. As a consequence, Dynamic Reliability Management (DRM) becomes an essential approach to assure IC's lifetime reliability. Accurate and efficient ... Keywords: dynamic reliability management, nbti, reliability

Yao Wang; Sorin D. Cotofana; Liang Fang

2013-05-01T23:59:59.000Z

185

Cascade Problems in Some Atomic Lifetime Measurements at a Heavy-Ion Storage Ring  

SciTech Connect

Lifetimes of 3s{sup 2}3p{sup k} ground configuration levels of Al-, Si-, P-, and S-like ions of Be, Co, and Ni have been measured at a heavy-ion storage ring. Some of the observed decay curves show strong evidence of cascade repopulation from specific 3d levels that feature lifetimes in the same multi-millisecond range as the levels of the ground configuration.

Tr?bert, E; Hoffmann, J; Krantz, C; Wolf, A; Ishikawa, Y; Santana, J

2008-10-09T23:59:59.000Z

186

Ratio of D/sup 0/ and D/sup +/ lifetimes from their semileptonic decays  

Science Conference Proceedings (OSTI)

The conventional expectation for the decays of D mesons assumes that the charm quark decays in the presence of light, spectator quarks and thus the lifetimes of both charged and uncharged states are equal. In this article, evidence is presented from DELCO (at SPEAR) that the D lifetimes are quite different for neutral and charged mesons, and the results which have also become available from other experiments are reviewed.

Donaldson, G.J.

1980-06-01T23:59:59.000Z

187

Lifetime and diffusion length measurements on silicon material and solar cells. [Intentionally doped with impurities  

DOE Green Energy (OSTI)

Experimental methods were evaluated for the determination of lifetime and diffusion length in silicon intentionally doped with potentially lifetime-degrading impurities found in metallurgical grade silicon, impurities which may be residual in low-cost silicon intended for use in terrestrial flat-plat arrays. Results obtained by these methods were compared for mutual consistency. Lifetime measurements were made using a steady-state photoconductivity method, which was compared with a photoconductivity decay technique. Diffusion length determinations were made using short-circuit current measurements under penetrating illumination. This method was compared with a direct measurement of diffusion length using a scanning electron microscope. Mutual consistency among all experimental methods was verified, but steady-state photoconductivity was found preferable to photoconductivity decay at short lifetimes and in the presence of traps. The effects of a number of impurities on lifetime in bulk material, and on diffusion length in cells fabricated from this material, were determined. Results were compared with those obtained by others on the same material and devices using different techniques. General agreement was found in terms of the hierarchy of impurities which degrade the lifetime.

Othmer, S.; Chen, S.C.

1977-01-01T23:59:59.000Z

188

Dosimetric Comparison of Intensity-Modulated Radiotherapy Plans, With or Without Anterior Myocardial Territory and Left Ventricle as Organs at Risk, in Early-Stage Left-Sided Breast Cancer Patients  

SciTech Connect

Purpose: We evaluated heart sparing using an intensity-modulated radiotherapy (IMRT) plan with the left ventricle (LV) and/or the anterior myocardial territory (AMT) as additional organs at risk (OARs). Methods and Materials: A total of 10 patients with left-sided breast cancer were selected for dosimetric planning. Both lungs, the right breast, heart, LV, and AMT were defined as OARs. We generated one tangential field plan and four IMRT plans for each patient. We examined the dose-volume histogram parameters of the planning target volume and OARs. Results: Compared with the tangential field plan, the mean dose to the heart in the IMRT plans did not show significant differences; however, the dose to the AMT and LV decreased by 18.7-45.4% and 10.8-37.4%, respectively. The maximal dose to the heart decreased by 18.6-35.3%, to the AMT by 22.0-45.1%, and to the LV by 23.5-45.0%, And the relative volumes of the heart (V{sub {>=}12}), AMT (V{sub >11}) and LV (V{sub >10}) decreased significantly with different levels, respectively. The volume of the heart, AMT, LV, both lungs, and right breast receiving {>=}5 Gy showed a significant increase. Compared with the IMRT (H) plan, the mean dose to the heart, AMT, and LV decreased by 17.5-21.5%, 25.2-29.8%, and 22.8-29.8% and the maximal dose by 13.6-20.6%, 23.1-29.6%, and 17.3-29.1%, respectively. The IMRT plans for both lungs and the right breast showed no significant differences. Conclusions: The IMRT plans with the addition of the AMT and/or LV as OARs considerably increased heart sparing. We recommend including the LV as an additional OAR in such plans.

Tan Wenyong [Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology College of Life Science and Technology, Wuhan (China); Wang Xiaohong; Qiu Dasheng [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Liu Dong [Department of Radiology, Hubei Cancer Hospital, Wuhan (China); Jia Shaohui; Zeng Fanyu [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Chen Zhengwang [Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology College of Life Science and Technology, Wuhan (China); Li Beihui; Xu Jiaozhen; Wei Lai [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Hu Desheng, E-mail: tanwyym@yahoo.com.cn [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China)

2011-12-01T23:59:59.000Z

189

Radiation risk to low fluences of particles may be greater than we thought  

E-Print Network (OSTI)

principally on the cancer incidence found in survivors of the atomic bombs dropped in Hiroshima and Nagasaki-induced cancer has traditionally been estimated from cancer incidence among survivors of the atomic bombs dropped in Hiroshima and Nagasaki in 1945. These data provide the best estimate of human cancer risk over the dose

190

Simulation free measurement of the B+ lifetime using decays selected using displaced tracks  

SciTech Connect

The lifetime of the B{sup {+-}} meson is measured using the decay channel B{sup +} {yields} {bar D}{sup 0}{pi}{sup +}. The measurement is made using approximately 1.0 fb{sup -1} of Tevatron proton-anti-proton collision data at {radical}s = 1.96 TeV collected by the CDF detector. The data were collected using impact parameter based triggers that were designed to select events with a secondary vertex. The trigger selection criteria result in data rich in a variety of B hadron decays, but intrinsically bias the lifetime distribution of the collected signal events. The traditional way to compensate for the bias is to use information from simulation. Presented here is a new method for correction of the lifetime bias using an analytical technique that uses information from the data only. This eliminates measurement uncertainty due to data and simulation agreement, ultimately resulting in a smaller systematic measurement uncertainty. The B{sup {+-}} lifetime measurement is the first measurement using this new technique and demonstrates its potential for use in future measurements. The B{sup {+-}} lifetime is measured to be {tau}(B{sup {+-}}) = 1.662 {+-} 0.023(stat) {+-} 0.015(syst)ps.

Malde, Sneha; /Oxford U.

2009-03-01T23:59:59.000Z

191

Vibrational Infrared Lifetime of the Anesthetic nitrous oxide gas in solution  

E-Print Network (OSTI)

The lifetime of the asymmetric fundamental stretching 2218 cm$^{-1}$ vibration of the anesthetic gas nitrous oxide (N$_2$O) dissolved in octanol and olive oil is reported. These solvents are model systems commonly used to assess anesthetic potency. Picosecond time-scale molecular dynamics simulations have suggested that protein dynamics or membrane dynamics play a role in the molecular mechanism of anesthetic action. Ultrafast infrared spectroscopy with 100 fs time resolution is an ideal tool to probe dynamics of anesthetic molecules on such timescales. Pump-probe studies at the peak of the vibrational band yield a lifetime of $55 \\pm 1$ ps in olive oil and $52 \\pm 1 ps$ in octanol. The similarity of lifetimes suggests that energy relaxation of the anesthetic is determined primarily by the hydrophobic nature of the environment, consistent with models of anesthetic action. The results show that nitrous oxide is a good model system for probing anesthetic-solvent interactions using nonlinear infrared spectroscop...

Chieffo, Logan; Shattuck, Jeffrey; Hong, Mi K; Ziegler, Lawrence; Erramilli, Shyamsunder

2006-01-01T23:59:59.000Z

192

Measuring Lifetimes of Long-Lived Charged Massive Particles Stopped in LHC Detectors  

Science Conference Proceedings (OSTI)

Long-lived charged massive particles (CHAMPs) appear in various particle physics models beyond the standard model. In this Letter, we discuss the prospects for studying the stopping and decaying events of such long-lived CHAMPs at the LHC detectors, and show that the lifetime measurement (and the study of decay products) is possible with the LHC detectors for a wide range of the lifetime O(0.1)-O(10{sup 10}) sec, by using periods of no pp collision. Even a short lifetime of order 1 sec can be measured by (i) identifying the stopping event with the on-line event filter, (ii) immediately making a beam-dump signal which stops the pp collision of the LHC, and at the same time (iii) changing the trigger menu to optimize it for the detection of a CHAMP decay in the calorimeter. Other possibilities are also discussed.

Asai, Shoji; Shirai, Satoshi [Department of Physics, University of Tokyo, Tokyo 113-0033 (Japan); Hamaguchi, Koichi [Department of Physics, University of Tokyo, Tokyo 113-0033 (Japan); Institute for the Physics and Mathematics of the Universe, University of Tokyo, Chiba 277-8568 (Japan)

2009-10-02T23:59:59.000Z

193

The Effective Lifetime of ACSR Full Tension Splice Connector Operated at Higher Temperature  

Science Conference Proceedings (OSTI)

This paper is to address the issues related to integrity of ACSR full tension splice connectors operated at high temperatures. A protocol of integrating analytical and experimental approaches to evaluate the integrity of a full tension single-stage splice connector (SSC) assembly during service at high operating temperature was developed. Based on the developed protocol the effective lifetime evaluation was demonstrated with ACSR Drake conductor SSC systems. The investigation indicates that thermal cycling temperature and frequency, conductor cable tension loading, and the compressive residual stress field within a SSC system have significant impact on the SSC integrity and the associated effective lifetime.

Wang, Jy-An John [ORNL; Lara-Curzio, Edgar [ORNL; King Jr, Thomas J [ORNL; Graziano, Joe [Tennessee Valley Authority (TVA); Chan, John [Electric Power Research Institute (EPRI); Goodwin, Tip [PBS& J

2009-01-01T23:59:59.000Z

194

Nuclear matrix elements from direct lifetime or cross-section measurements  

SciTech Connect

The method of simultaneous lifetime and g factor measurements using a plunger device and the RDDS and TDRIV techniques is introduced. Results on lifetimes and hyperfine-interaction parameters for 2{sup +}{sub 1} states in {sup 104-108}Pd, {sup 96,98,104}Ru, and {sup 92,94}Zr, using a plunger device. Another method to obtain electromagnetic matrix elements is direct cross section measurements using NRF. The method is outlined, and some recent results on {sup 76}Se are shown.

Werner, V.; Cooper, N.; Hinton, M.; Ilie, G.; Radeck, D. [Wright Nuclear Structure Laboratory, Yale University, P.O. Box 208120, New Haven, CT 06520-8120 (United States); Wright Nuclear Structure Laboratory, Yale University, P.O. Box 208120, New Haven, CT 06520-8120 (United States) and Department of Physics, University of Surrey, Guilford, GU27XH (United Kingdom); Wright Nuclear Structure Laboratory, Yale University, P.O. Box 208120, New Haven, CT 06520-8120 (United States) and National Institute for Physics and Nuclear Engineering, P.O. Box MG-6, Bucharest-Magurele (Romania); Wright Nuclear Structure Laboratory, Yale University, P.O. Box 208120, New Haven, CT 06520-8120 (United States) and Institut fuer Kernphysik, Universitaet zu Koeln, Zuelpicher Str. 77, 50937 Koeln (Germany)

2012-11-20T23:59:59.000Z

195

THE LIFETIME OF AEROSOL DROPLETS IN AMBIENT AIR: CONSIDERATION OF THE EFFECTS OF SURFACTANTS AND CHEMICAL REACTIONS  

E-Print Network (OSTI)

of various urban sulfate aerosol production mechanisms.radius of an evaporating aerosol droplet in which oxidationEnvironment THE LIFETIME OF AEROSOL DROPLETS IN AMBIENT AIR:

Toossi, R.

2013-01-01T23:59:59.000Z

196

Framework for Risk-Informed Safety Margin Characterization  

Science Conference Proceedings (OSTI)

Commercial nuclear power plants in operation continue to undergo design and operational changes to support cost-effective long-term operation. Additionally, as plant operational lifetimes are extended, it is imperative that they effectively manage aging degradation, prevent the occurrence of any safety-significant operational events, and analytically demonstrate acceptable (and even improved) nuclear safety risk. This report describes initial research to develop and validate an integrated framework and a...

2009-12-22T23:59:59.000Z

197

Potential Operational Risk Due to Changes in Arsenic Regulatory Values  

Science Conference Proceedings (OSTI)

Inorganic arsenic (iAs) is an environmentally ubiquitous toxic metalloid associated with an increased risk of both cancer and non-cancer effects in exposed individuals. However, disagreement exists on what level exists, if any, that will not result in adverse health outcomes. As such, federal and state agencies rely on the development of scientific estimates of the exposure-to-response relationship to characterize and manage risk across an array of regulatory programs. In the United States, the ...

2012-12-31T23:59:59.000Z

198

Efficient Battery Management for Sensor Lifetime Malka N. Halgamuge, Student Member, IEEE  

E-Print Network (OSTI)

Efficient Battery Management for Sensor Lifetime Malka N. Halgamuge, Student Member, IEEE It is challenging to design a sensor network if sensors are battery powered. Efficient scheduling and budgeting battery power in sensor networks has become a critical issue in net- work design. We investigate how

Halgamuge, Malka N.

199

Internal Resistance Identification in Vehicle Power Lithium-Ion Battery and Application in Lifetime Evaluation  

Science Conference Proceedings (OSTI)

According to the characteristic analysis of lithium-ion power battery, battery accelerate life test is carried out to obtain the relevant conclusions such as the changing trend of battery ohmic resistance in different conditions. Battery ohmic resistance ... Keywords: Lithium-ion battery, Internal resistance, Equivalent model, Lifetime evaluation

Xuezhe Wei; Bing Zhu; Wei Xu

2009-04-01T23:59:59.000Z

200

Photoconductive Decay Lifetime and Suns-Voc Diagnostics of Efficient Heterojunction Solar Cells: Preprint  

DOE Green Energy (OSTI)

We report results of minority carrier lifetime measurements for double-sided p-type Si heterojunction devices and compare Suns-Voc results to Light I-V measurements on 1 cm2 solar cell devices measured on an AM1.5 calibrated XT-10 solar simulator.

Page, M. R.; Iwaniczko, E.; Xu, Y.; Roybal L.; Bauer, R.; Yan, H.-C.; Wang, Q.; Meier, D. L.

2008-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

REACTIVITY LIFETIME. TEST RESULTS DL-S-225(T-612118A). Section I, Second Performance  

SciTech Connect

The performance, reliability, stability, and reactivity lifetime variations of the Shippingport PWR are determined under normal steady state conditions. These characteristics are studied over a period of 758 EFPH, at a power level of about 60 Mw(e). Flux-tilt corrections and plant operations during this time are described. (T.F.H.)

1959-03-01T23:59:59.000Z

202

PGCapping: exploiting power gating for power capping and core lifetime balancing in CMPs  

Science Conference Proceedings (OSTI)

Optimizing the performance of a chip multiprocessor (CMP) within a power cap has recently received a lot of attention. However, most existing solutions rely solely on DVFS, which is anticipated to have only limited actuation ranges in the future. Power ... Keywords: chip multiprocessor, control theory, lifetime balancing, power capping, power control, power gating

Kai Ma; Xiaorui Wang

2012-09-01T23:59:59.000Z

203

A new extended Birnbaum-Saunders regression model for lifetime modeling  

Science Conference Proceedings (OSTI)

A new class of extended Birnbaum-Saunders regression models is introduced. It can be applied to censored data and be used more effectively in survival analysis and fatigue life studies. Maximum likelihood estimation of the model parameters with censored ... Keywords: Birnbaum-Saunders distribution, Censored data, Fatigue life distribution, Lifetime data, Local influence analysis

Artur J. Lemonte

2013-08-01T23:59:59.000Z

204

Radiative lifetime of the $a\\ ^3\\Sigma^+$ state of HeH$^+$ from ab initio calculations  

E-Print Network (OSTI)

The first metastable triplet state of HeH$^+$ was found to be present in ion beam experiments, with its lifetime estimated to be between hundreds of milliseconds and thousand of seconds. In this work, we use {\\it ab initio} methods to evaluate the radiative lifetimes of the six vibrational levels of the $a\\ ^3\\Sigma^+$ of HeH$^+$. The transition $a\\ ^3\\Sigma^+ \\rightarrow X \\ ^1\\Sigma^+$ is spin-forbidden, but acquires intensity through spin-orbit interaction with the singlet and triplet $\\Pi$ states. Large scale CASSCF/MRCI calculations using an adapted basis set were performed to determine the potential energy curves of the relevant states of HeH$^+$ as well as the matrix elements of the dipole and spin-orbit operators. The wave functions and energies of the vibrational levels of the $a\\ ^3\\Sigma^+$ and $X \\ ^1\\Sigma^+$ states are obtained using a B-spline method and compared to previous works. We find that radiative lifetime of the vibrational levels increases strongly with $v$, the lifetime of the $v=0$ s...

Loreau, J; Vaeck, N

2010-01-01T23:59:59.000Z

205

Enhancement of photoluminescence lifetime of ZnO nanorods making use of thiourea  

Science Conference Proceedings (OSTI)

We have investigated correlation of photoluminescence lifetime between zinc oxide (ZnO) nanorods and thiourea-doped ZnO nanorods (tu: CH4N2S). Aqueous solutions of ZnO nanorods were deposited on glass substrate by using pneumatic ...

Erdal Sönmez; Kadem Meral

2012-01-01T23:59:59.000Z

206

Coverage-Based Information Retrieval for Lifetime Maximization in Sensor Networks  

E-Print Network (OSTI)

Coverage-Based Information Retrieval for Lifetime Maximization in Sensor Networks Tong Zhao {ttzhao, qzhao}@ece.ucdavis.edu Abstract--We consider information retrieval in a wireless sensor network-of-service (QoS) specific information retrieval for the reconstruction of a spatially correlated random signal

Islam, M. Saif

207

ATA: adaptive transmission algorithms for prolonging lifetime in underwater sensor networks  

Science Conference Proceedings (OSTI)

The severe energy constraints of sensors and the unique characteristics of underwater sensor networks (UWSNs) present major challenges for the long-term monitoring applications. This paper proposes two novel adaptive transmission algorithms for UWSNs ... Keywords: algorithms, lifetime, underwater sensor networks

Zhongwen Guo; Jinfeng Dou; Wei Han; Guangxu Zhang; Zhengang Ha

2008-05-01T23:59:59.000Z

208

Alternative Size and Lifetime Measurements for High-Energy Heavy-Ion Collisions  

E-Print Network (OSTI)

Two-Particle correlations based on the interference of identical particles has provided the chief means for determining the shape and lifetime of sources in relativistic heavy ion collisions. Here, Strong and Coulomb induced correlations are shown to provide equivalent information.

Scott Pratt; Silvio Petriconi

2003-05-07T23:59:59.000Z

209

Experimental determination of neutron lifetimes through macroscopic neutron noise in the IPEN/MB-01 reactor  

SciTech Connect

The neutron lifetimes of the core, reflector, and global were experimentally obtained through macroscopic neutron noise in the IPEN/MB-01 reactor for five levels of subcriticality. The theoretical Auto Power Spectral Densities were derived by point kinetic equations taking the reflector effect into account, and one of the approaches consider an additional group of delayed neutrons.

Gonnelli, Eduardo; Diniz, Ricardo [Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP Travessa R-400, 05508-900, Cidade Universitaria, Sao Paulo (Brazil)

2013-05-06T23:59:59.000Z

210

Network lifetime analytical model for node-disjoint multipath routing in wireless sensor networks  

Science Conference Proceedings (OSTI)

The objective of every sensor node in a sensor network is to send the sensed data in the phenomena to a sink node. The network lifetime is maximal, when the energy consumption of each node is uniform. Many routing protocols select an optimal path to ...

Shiva G. Murthy; R. J. D. Souza; G. Varaprasad

2013-02-01T23:59:59.000Z

211

Development of a high average current polarized electron source with long cathode operational lifetime  

SciTech Connect

Substantially more than half of the electromagnetic nuclear physics experiments conducted at the Continuous Electron Beam Accelerator Facility of the Thomas Jefferson National Accelerator Facility (Jefferson Laboratory) require highly polarized electron beams, often at high average current. Spin-polarized electrons are produced by photoemission from various GaAs-based semiconductor photocathodes, using circularly polarized laser light with photon energy slightly larger than the semiconductor band gap. The photocathodes are prepared by activation of the clean semiconductor surface to negative electron affinity using cesium and oxidation. Historically, in many laboratories worldwide, these photocathodes have had short operational lifetimes at high average current, and have often deteriorated fairly quickly in ultrahigh vacuum even without electron beam delivery. At Jefferson Lab, we have developed a polarized electron source in which the photocathodes degrade exceptionally slowly without electron emission, and in which ion back bombardment is the predominant mechanism limiting the operational lifetime of the cathodes during electron emission. We have reproducibly obtained cathode 1/e dark lifetimes over two years, and 1/e charge density and charge lifetimes during electron beam delivery of over 2?105???C/cm2 and 200 C, respectively. This source is able to support uninterrupted high average current polarized beam delivery to three experimental halls simultaneously for many months at a time. Many of the techniques we report here are directly applicable to the development of GaAs photoemission electron guns to deliver high average current, high brightness unpolarized beams.

C. K. Sinclair; P. A. Adderley; B. M. Dunham; J. C. Hansknecht; P. Hartmann; M. Poelker; J. S. Price; P. M. Rutt; W. J. Schneider; M. Steigerwald

2007-02-01T23:59:59.000Z

212

Prolonging the lifetime of wireless sensor networks using multi-level clustering and heterogeneity  

Science Conference Proceedings (OSTI)

Clustering in wireless sensor networks (WSNs) is an important technique to prolong lifetime of a WSN. This paper proposes energy efficient multi-level clustering scheme called Power Aware Multi-level Clustering (PAMC) for homogeneous wireless sensor ... Keywords: algorithm, energy efficiency, heterogeneity, multi-level clustering, wireless sensor networks

Surender Soni; Vivek Katiyar

2011-02-01T23:59:59.000Z

213

Measurement of the Masses and Lifetimes of B Hadrons at the Tevatron  

SciTech Connect

The latest results for the B Hadron sector at the Tevatron Collider are summarized. The properties of B hadrons can be precisely measured at the Tevatron. In particularly they will focus on the masses and lifetimes. The new Tevatron results for the CP violation in B Hadrons are also discussed.

Catastini, Pierluigi; /Pisa U. /INFN, Pisa

2006-05-01T23:59:59.000Z

214

Energy-optimal SRAM supply voltage scheduling under lifetime and error constraints  

Science Conference Proceedings (OSTI)

This work addresses the energy efficiency of the memory architecture in safety-critical systems that have to guarantee a given level of service and a minimum lifetime. We specifically target SRAM structures in which decreased reliability manifests itself ... Keywords: NBTI, SRAM, aging, energy optimization, reliability

Andrea Calimera, Enrico Macii, Massimo Poncino

2013-05-01T23:59:59.000Z

215

Measurement and model assessment of fluorescence lifetime sensing in multiply scattering media  

E-Print Network (OSTI)

The generation and propagation of fluorescence light within biological tissue offers the potential for biomedical diagnostics and analyte sensing. Arising from an exogenous fluorescent dye injected as a contrast agent or immobilized in a polymer implant, the fluorescent decay kinetics can be sensitive to the tissue??s biochemical environment, providing quantitative in vivo information of the confined tissue site. The impact of light propagation and decay kinetics upon the measured signals is important for consideration, simply because tissue scatters light, giving rise to nanosecond photon time-of-flights that are comparable to fluorescence relaxation kinetics. The goal of this study is to develop a time-dependent model describing (i) the generation of fluorescence from dyes exhibiting multi-exponential or more complex kinetics and (ii) its propagation in scattering media. In the preliminary study, fluorescence lifetime spectroscopy is investigated in tissue-like scattering solution. Two fluorescent dyes, 3,3-diethylthiatricarbocyanine iodide (DTTCI) and Indocynanine Green (ICG), which exhibit distinctly different lifetimes and each exhibits single-exponential decay kinetics, were employed. Measurements of phase-modulation as a function of modulation frequency were made at varying concentration ratios of the two dyes to experimentally simulate fluorescence multi-exponential decay kinetics in non-scattering and scattering solutions. The results suggest that frequency-domain measurements of fluorescent decay kinetics along with models of light propagation may be enhanced by scatter in order to probe kinetics more sensitively than in non-scattering solutions. The next study involved fluorescence lifetime sensing in scattering and non-scattering solutions with a pH sensitive dye, Carboxy Seminaphthofluorescein-1 (C-SNAFL-1), which is known to exhibit multi-exponential decay kinetics. The results demonstrate accurate pH sensing in scattering solution via fluorescence kinetics using a simplified propagation model incorporating an average lifetime. Finally, fluorescence lifetime sensing in immobilized systems were investigated. C-SNAFL-1 was immobilized in poly(ethylene glycol) (PEG) microparticles that were immersed in buffered polystyrene solutions. The results demonstrate the ability to perform pH sensing with fluorescence lifetime without the confounding effect of fluorophore loading or the use of 'reference' measurement within multiply scattering systems. In addition, the stability of the immobilized fluorescence sensor and the reliability of fluorescence lifetime measurement verify the prospect of this technology for implantable purposes.

Kuwana, Eddy

2003-05-01T23:59:59.000Z

216

Wafer Preparation and Iodine-Ethanol Passivation Procedure for Reproducible Minority-Carrier Lifetime Measurement (Poster)  

DOE Green Energy (OSTI)

Measurement of the bulk minority-carrier lifetime (T{sub b}) by optical methods, such as photocurrent decay or quasi-steady-state photoconductance (QSSPC), is strongly influenced by surface recombination. Several techniques are known to lower the effective surface recombination velocity, including the following: use of oxidation, floating N/P junction, SiN:H layer, HF immersion, and use of iodine in ethanol or methanol (I-E solution). Using I-E appears to be very simple and does not require any high-temperature treatment such as oxidation, diffusion, or nitridation processes, which can change T{sub b}. However, this is not a preferred procedure within the photovoltaic community because it is difficult to obtain same T{sub b} values reproducibly, particularly when the wafer lifetime is long. The objectives are: (1) Investigate various reasons why lifetime measurements may be irreproducible using I-E solution passivation. (2) Study the influence of the strength of iodine in the ethanol solution, wafer-cleaning procedures, influence of the wafer container during lifetime measurements, and the stability of I-E. (3) Compare lifetimes of wafers (having different T{sub b}) by various techniques such as QSSPC and transient photoconductive decay using short laser pulses of different light intensity; (4) Make minority-carrier diffusion length (L) measurements by a surface photovoltage technique, and to use T{sub b} and L data to determine diffusivity (D) values for various impurity and defect concentrations, using the relationship L{sup 2} = D* T{sub b}.

Sopori, B.; Rupnowski, P.; Appel, J.; Mehta, V.; Li, C.; Johnston, S.

2008-05-01T23:59:59.000Z

217

doi:10.5402/2011/617082 Research Article Epithelial Ovarian Cancer and the Occurrence of Skin Cancer in  

E-Print Network (OSTI)

Copyright © 2011 Catharina C. van Niekerk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Patients with epithelial ovarian cancer have a high risk of (non-)melanoma skin cancer. The association between histological variants of primary ovarian cancer and skin cancer is poorly documented. Objectives. To further evaluate the risk of skin cancer based on the histology of the epithelial ovarian cancer. Methods. A cross-sectional study within a large populationbased dataset. Results. Skin cancer was found in 2.7 % (95 % CI: 2.3–3.1) of the 5366 individuals forming our dataset. The odds ratio (OR) for endometrioid cancer in the ovary to skin cancer in the under 50 age group was 8.9 (95 % CI: 3.2–25.0). The OR decreased in older patients to 1.2. Conclusions. Patients with epithelial ovarian malignancies show an increased risk of skin cancer. A significantly increased risk (4.3%) for endometrioid ovarian cancer was found in the group aged under 50. 1.

Isrn Obstetrics; Catharina C. Van Niekerk; Johan Bulten; Andrél. M. Verbeek

2011-01-01T23:59:59.000Z

218

Wafer Preparation and Iodine-Ethanol-Ethanol Passivation Procedure for Reproducible Minority-Carrier Lifetime Measurement: Preprint  

DOE Green Energy (OSTI)

This paper describes reasons that lifetime measurments may be irreproducible using iodine-in-ethanol (I-E) passivation. Possible factors include the strength of the iodine in ethanol solution, wafer cleaning procedures, influence of wafer container during lifetime measurement, and stability of I-E.

Sopori, B.; Rupnowski, P.; Appel, J.; Mehta, V.; Li, C.; Johnston, S.

2008-05-01T23:59:59.000Z

219

Benefits of quantile regression for the analysis of customer lifetime value in a contractual setting: An application in financial services  

Science Conference Proceedings (OSTI)

The move towards a customer-centred approach to marketing, coupled with the increasing availability of customer transaction data, has led to an interest in understanding and estimating customer lifetime value (CLV). Several authors point out that, when ... Keywords: Customer lifetime value, Customer relationship management (CRM), Customer segmentation, Database marketing, Prediction interval, Quantile regression

Dries F. Benoit; Dirk Van den Poel

2009-09-01T23:59:59.000Z

220

MO?F?103?01: Estimating Risk of Low Radiation Doses  

Science Conference Proceedings (OSTI)

Several articles in the medical literature over the past few years have predicted thousands of cancers and cancer deaths annually in the US population caused by radiation exposures from medical imaging. The predictions are derived from risk estimates in the National Academy of Sciences BEIR VII report. These risk estimates are highly speculative with wide confidence intervals

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Materials Lifetime  

Science Conference Proceedings (OSTI)

Tel: (765) 456-6218. E-mail: pliaw@utk.edu. E-mail: rab1@utk.edu. Fax: (765) 456-6925. Email:dklarstrom@haynesintl.com. Dr. R. P. Wei. Dr. D. G. Harlow.

222

B Lifetime  

NLE Websites -- All DOE Office Websites (Extended Search)

Project Contact: Thomas Jordan - jordant@fnal.gov Web Maintainer: qnet-webmaster@fnal.gov Last Update: April 13, 2001 http:quarknet.fnal.govrun2transverse...

223

B Lifetime  

NLE Websites -- All DOE Office Websites (Extended Search)

the beam pipe (2.5 cm)? References Assignments: Identifying B Project Contact: Thomas Jordan - jordant@fnal.gov Web Maintainer: qnet-webmaster@fnal.gov Last Update: January 10,...

224

Particle Lifetimes  

NLE Websites -- All DOE Office Websites (Extended Search)

Finding the Energy-Momentum Relationship       In classical physics, we can say that if we hold potential energy to be zero, then the total energy of an object...

225

Risk Management Tool Attributes:  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

- Tools & SMEs - Tools & SMEs Outline for Breakout Session TOOLS 1. Types of Tools a. Risk Management - Database & Reports, risk register, risk forms, risk tracking & monitoring, basis of estimate, action item tracking, historical record of risks & changes, configuration control, enterprise-wide, metrics, risk performance index, risk checklist, graphical display, management reporting (various levels), risk communications b. Risk Analysis i. Cost, ii. budgets, funding, cash-flow analysis, iii. Schedule iv. tailoring categories v. Integrated Cost & Schedule vi. Project phase analysis; organization ownership & joint planning c. Risk Knowledge and Lessons Learned Database i. Enterprise-wide ii. Job/owner-specific iii. Workshops - project specific, risk management,

226

Spontaneous fission lifetimes from the minimization of self-consistent collective action  

E-Print Network (OSTI)

The spontaneous fission lifetime of 264Fm has been studied within nuclear density functional theory by minimizing the collective action integral for fission in a two-dimensional quadrupole collective space representing elongation and triaxiality. The collective potential and inertia tensor are obtained self-consistently using the Skyrme energy density functional and density-dependent pairing interaction. The resulting spontaneous fission lifetimes are compared with the static result obtained with the minimum-energy pathway. We show that fission pathways strongly depend on assumptions underlying collective inertia. With the non-perturbative mass parameters, the dynamic fission pathway becomes strongly triaxial and it approaches the static fission valley. On the other hand, when the standard perturbative cranking inertia tensor is used, axial symmetry is restored along the path to fission; an effect that is an artifact of the approximation used.

Jhilam Sadhukhan; K. Mazurek; A. Baran; J. Dobaczewski; W. Nazarewicz; J. A. Sheikh

2013-10-08T23:59:59.000Z

227

History-based, online, battery lifetime prediction for embedded and mobile devices  

E-Print Network (OSTI)

This paper presents a novel, history-based, statistical technique for online battery lifetime prediction. The approach first takes a one-time, full cycle, voltage measurement of a constant load, and uses it to transform the partial voltage curve of the current workload into a form with robust predictability. Based on the transformed history curve, we apply a statistical method to make a lifetime prediction. We investigate the performance of the implementation of our approach on a widely used mobile device (HP iPAQ) running Linux, and compare it to two similar battery prediction technologies: ACPI and Smart Battery. We employ twenty-two constant and variable workloads to verify the efficacy of our approach. Our results show that this approach is efficient, accurate, and able to adapt to different systems and batteries easily. 1

Ye Wen; Rich Wolski; Chandra Krintz

2003-01-01T23:59:59.000Z

228

Phosphazene Based Additives for Improvement of Safety and Battery Lifetimes in Lithium-Ion Batteries  

DOE Green Energy (OSTI)

There need to be significant improvements made in lithium-ion battery technology, principally in the areas of safety and useful lifetimes to truly enable widespread adoption of large format batteries for the electrification of the light transportation fleet. In order to effect the transition to lithium ion technology in a timely fashion, one promising next step is through improvements to the electrolyte in the form of novel additives that simultaneously improve safety and useful lifetimes without impairing performance characteristics over wide temperature and cycle duty ranges. Recent efforts in our laboratory have been focused on the development of such additives with all the requisite properties enumerated above. We present the results of the study of novel phosphazene based electrolytes additives.

Mason K Harrup; Kevin L Gering; Harry W Rollins; Sergiy V Sazhin; Michael T Benson; David K Jamison; Christopher J Michelbacher

2011-10-01T23:59:59.000Z

229

Laser spectroscopy of the antiprotonic helium atom – its energy levels and state lifetimes  

E-Print Network (OSTI)

The antiprotonic atom is a three-body exotic system consisting of an antiproton, an electron and a helium nucleus. Its surprising longevity was found and has been studied for more than 10 years. In this work, transition energies and lifetimes of this exotic atom were systematically studied by using the antiproton beam of AD(Antiproton Decelerator) facility at CERN, with an RFQ antiproton decelerator, a narrow-bandwidth laser, Cerenkov counters with fast-response photomultiplier tubes, and cryogenic helium target systems. Thirteen transition energies were determined with precisions of better than 200 ppb by a laser spectroscopy method, together with the elimination of the shift effect caused by collisions with surrounding atoms. Fifteen lifetimes (decay rates) of short-lived states were determined from the time distributions of the antiproton-annihilation signals and the resonance widths of the atomic spectral lines. The relation between the magnitude of the decay rates and the transition multipolarity was inv...

Hidetoshi, Yamaguchi

2003-01-01T23:59:59.000Z

230

Theory of SEI Formation in Rechargeable Batteries: Capacity Fade, Accelerated Aging and Lifetime Prediction  

E-Print Network (OSTI)

Cycle life is critically important in applications of rechargeable batteries, but lifetime prediction is mostly based on empirical trends, rather than mathematical models. In practical lithium-ion batteries, capacity fade occurs over thousands of cycles, limited by slow electrochemical processes, such as the formation of a solid-electrolyte interphase (SEI) in the negative electrode, which compete with reversible lithium intercalation. Focusing on SEI growth as the canonical degradation mechanism, we show that a simple single-particle model can accurately explain experimentally observed capacity fade in commercial cells with graphite anodes, and predict future fade based on limited accelerated aging data for short times and elevated temperatures. The theory is extended to porous electrodes, predicting that SEI growth is essentially homogeneous throughout the electrode, even at high rates. The lifetime distribution for a sample of batteries is found to be consistent with Gaussian statistics, as predicted by th...

Pinson, Matthew B

2012-01-01T23:59:59.000Z

231

Comparison of Accelerated Testing with Modeling to Predict Lifetime of CPV Solder Layers (Presentation)  

DOE Green Energy (OSTI)

Concentrating photovoltaic (CPV) cell assemblies can fail due to thermomechanical fatigue in the die-attach layer. In this presentation, we show the latest results from our computational model of thermomechanical fatigue. The model is used to estimate the relative lifetime of cell assemblies exposed to various temperature histories consistent with service and with accelerated testing. We also present early results from thermal cycling experiments designed to help validate the computational model.

Silverman, T. J.; Bosco, N.; Kurtz, S.

2012-03-01T23:59:59.000Z

232

Lifetime of oil drops pressed by buoyancy against a planar interface: Large drops  

E-Print Network (OSTI)

In a previous report [10] it was shown that emulsion stability simulations are able to reproduce the lifetime of micrometer-size drops of hexadecane pressed by buoyancy against a planar water-hexadecane interface. It was confirmed that small drops (rioil stabilized with bovine serum albumin. The potential obtained is then employed to study the lifetime of deformable drops in the range 10 \\leq ri \\leq 1000 {\\mu}m. It is established that the average lifetime of these drops can be adequately replicated using the model of truncated spheres. However, the results depend sensibly on the expressions of the initial distance of deformation and the maximum film radius used in the calculations. The set of equations adequate for large drops is not satisfactory for medium-size drops (10 \\leq ri \\leq 100 {\\mu}m), and vice versa. In the case of large particles, the increase in the interfacial area as a consequence of the deformation of the drops generates a very large repulsive barrier which opposes coalescence. Nevertheless, the buoyancy force prevails. As a consequence, it is the hydrodynamic tensor of the drops which determine the characteristic behavior of the lifetime as a function of the particle size. While the average values of the coalescence time of the drops can be justified by the mechanism of film thinning, the scattering of the experimental data of large drops cannot be rationalized using the methodology previously described. A possible explanation of this phenomenon required elaborate simulations which combine deformable drops, capillary waves, repulsive interaction forces, and a time-dependent surfactant adsorption.

Clara Rojas; Máximo García-Sucre; Germán Urbina-Villalba

2010-12-15T23:59:59.000Z

233

Quasi-particle Lifetimes in a dx2?y2 Superconductor  

E-Print Network (OSTI)

We consider the lifetime of quasi-particles in a d-wave superconductor due to scattering from antiferromagnetic spin-fluctuations, and explicitly separate the contribution from Umklapp processes which determines the electrical conductivity. Results for the temperature dependence of the total scattering rate and the Umklapp scattering rate are compared with relaxation rates obtained from thermal and microwave conductivity measurements, respectively. Typeset using REVTEX

Daniel Duffy; P. J. Hirschfeld; Douglas J. Scalapino

2008-01-01T23:59:59.000Z

234

Spontaneous fission modes and lifetimes of super-heavy elements in the nuclear density functional theory  

E-Print Network (OSTI)

Lifetimes of super-heavy (SH) nuclei are primarily governed by alpha decay and spontaneous fission (SF). Here we study the competing decay modes of even-even SH isotopes with 108 cold fusion" and "hot fusion" reactions. The region of long-lived SH nuclei is expected to be centered on $^{294}$Ds with a total half-life of ?1.5 days.

A. Staszczak; A. Baran; W. Nazarewicz

2012-08-06T23:59:59.000Z

235

Renewals for exponentially increasing lifetimes, with an application to digital search trees  

E-Print Network (OSTI)

We show that the number of renewals up to time $t$ exhibits distributional fluctuations as $t\\to\\infty$ if the underlying lifetimes increase at an exponential rate in a distributional sense. This provides a probabilistic explanation for the asymptotics of insertion depth in random trees generated by a bit-comparison strategy from uniform input; we also obtain a representation for the resulting family of limit laws along subsequences. Our approach can also be used to obtain rates of convergence.

Dennert, Florian

2007-01-01T23:59:59.000Z

236

Source fabrication and lifetime for Li{sup +} ion beams extracted from alumino-silicate sources  

SciTech Connect

A space-charge-limited beam with current densities (J) exceeding 1 mA/cm{sup 2} have been measured from lithium alumino-silicate ion sources at a temperature of {approx}1275 deg. C. At higher extraction voltages, the source appears to become emission limited with J{>=} 1.5 mA/cm{sup 2}, and J increases weakly with the applied voltage. A 6.35 mm diameter source with an alumino-silicate coating, {<=}0.25 mm thick, has a measured lifetime of {approx}40 h at {approx}1275 deg. C, when pulsed at 0.05 Hz and with pulse length of {approx}6 {mu}s each. At this rate, the source lifetime was independent of the actual beam charge extracted due to the loss of neutral atoms at high temperature. The source lifetime increases with the amount of alumino-silicate coated on the emitting surface, and may also be further extended if the temperature is reduced between pulses.

Roy, Prabir K.; Greenway, Wayne G.; Kwan, Joe W. [Lawrence Berkeley National Laboratory (LBNL), One Cyclotron Road, Berkeley, California 94720 (United States)

2012-04-15T23:59:59.000Z

237

Source fabrication and lifetime for Li+ ion beams extracted from alumino-silicate sources  

Science Conference Proceedings (OSTI)

A space-charge-limited beam with current densities (J) exceeding 1 mA/cm{sup 2} have been measured from lithium alumino-silicate ion sources at a temperature of #24;~1275#14;{degrees} C. At higher extraction voltages, the source appears to become emission limited with J #21;{>=} 1.5 mA/cm{sup 2}, and J increases weakly with the applied voltage. A 6.35 mm diameter source with an alumino-silicate coating, {<=}#20;0.25 mm thick, has a measured lifetime of ~#24;40 hours at ~#24;1275#14;{degrees} C, when pulsed at 0.05 Hz and with pulse length of #24;~6 ?s each. At this rate, the source lifetime was independent of the actual beam charge extracted due to the loss of neutral atoms at high temperature. The source lifetime increases with the amount of alumino-silicate coated on the emitting surface, and may also be further extended if the temperature is reduced between pulses.

Roy, Prabir K.; Greenway, Wayne G.; Kwan, Joe W

2012-03-05T23:59:59.000Z

238

Source fabrication and lifetime for Li+ ion beams extracted from alumino-silicate sources  

SciTech Connect

A space-charge-limited beam with current densities (J) exceeding 1 mA/cm{sup 2} have been measured from lithium alumino-silicate ion sources at a temperature of #24;~1275#14;{degrees} C. At higher extraction voltages, the source appears to become emission limited with J #21;{>=} 1.5 mA/cm{sup 2}, and J increases weakly with the applied voltage. A 6.35 mm diameter source with an alumino-silicate coating, {<=}#20;0.25 mm thick, has a measured lifetime of ~#24;40 hours at ~#24;1275#14;{degrees} C, when pulsed at 0.05 Hz and with pulse length of #24;~6 μs each. At this rate, the source lifetime was independent of the actual beam charge extracted due to the loss of neutral atoms at high temperature. The source lifetime increases with the amount of alumino-silicate coated on the emitting surface, and may also be further extended if the temperature is reduced between pulses.

Roy, Prabir K.; Greenway, Wayne G.; Kwan, Joe W

2012-03-05T23:59:59.000Z

239

Macroparticle simulations of antiproton lifetime at 150 GeV in the te vatron  

SciTech Connect

In this paper we report on a systematic study of antiproton lifetime at the injection energy of 150 GeV in the Tevatron. Our parallel beam-beam model can handle both strong-strong and weak-strong beam-beam collisions with arbitrary beam-beam separation and beam distributions. In this study, we have only used the weak-strong capability due to the fact that the antiproton intensity is much smaller than the proton intensity. We have included all 72 long-range beam-beam collisions with a linear transfer map between adjacent collision points and taken into account linear chromaticity. The effects of antiproton emittance, beam-beam separation, proton intensity, and machine chromaticity have been investigated. Initial results show that the antiproton lifetime as a function of the proton intensity from the simulation is in good agreement with that from the experimental measurements. The antiproton lifetime can be significantly improved by increasing the beam separation and by reducing the antiproton emittance.

Qiang, Ji; Ryne, Robert D.; Sen, Tanaji; Xiao, Meiqin

2003-05-09T23:59:59.000Z

240

Excitation energies, polarizabilities, multipole transition rates, and lifetimes of ions along the francium isoelectronic sequence  

E-Print Network (OSTI)

Relativistic many-body perturbation theory is applied to study properties of ions of the francium isoelectronic sequence. Specifically, energies of the 7s, 7p, 6d, and 5f states of Fr-like ions with nuclear charges Z = 87 - 100 are calculated through third order; reduced matrix elements, oscillator strengths, transition rates, and lifetimes are determined for 7s - 7p, 7p - 6d, and 6d - 5f electric-dipole transitions; and 7s - 6d, 7s - 5f, and 5f_5/2 - 5f_7/2 multipole matrix elements are evaluated to obtain the lifetimes of low-lying excited states. Moreover, for the ions Z = 87 - 92 calculations are also carried out using the relativistic all-order single-double method, in which single and double excitations of Dirac-Fock wave functions are included to all orders in perturbation theory. With the aid of the SD wave functions, we obtain accurate values of energies, transition rates, oscillator strengths, and the lifetimes of these six ions. Ground state scalar polarizabilities in Fr I, Ra II, Ac III, and Th IV...

Safronova, U I; Safronova, M S

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Ensure Long Lifetimes from Electrolytic Capacitors: a Case Study in LED Light Bulbs  

E-Print Network (OSTI)

Abstract: Electrolytic capacitors are notorious for short lifetimes in high-temperature applications such as LED light bulbs. The careful selection of these devices with proper interpretation of their specifications is essential to ensure that they do not compromise the life of the end product. This application note discusses this problem with electrolytic capacitors in LED light bulbs and provides an analysis that shows how it is possible to use electrolytics in such products. A similar version of this article appeared on EDN, April 6, 2013. Hot LEDs and Short-Lived Electrolytic Capacitors Several years ago, I worked on a few designs for LED light bulbs. Very early on, it became clear that the temperatures of components in such light bulbs can get quite high. I personally measured component temperatures as high as +130°C in light bulbs purchased at local retail stores. Now admittedly, these were early LED bulb designs. Manufacturers now understand that, even though these LED bulbs consume substantially lower power than those they would replace, they still must have good thermal engineering. This is the only way to get the lifetime of the electronics to match the lifetime of the LEDs themselves. I found it disturbing that many of these hot designs contained electrolytic capacitors, which are notorious

Mark Fortunato; Senior Principal; Member Technical Staff

2013-01-01T23:59:59.000Z

242

Measurement of D0 lifetime with the BaBar detector  

SciTech Connect

This work is the result of the researchers carried out during a three years Ph.D. period in the BABAR experiment. The first chapter consists in an introduction to the theoretical aspects of the D{sup 0} meson lifetime determination and CP violation parameters, as well as an overview of the CP violation in the B sector, which is the main topic of the experiment. The description of the experimental apparatus follows with particular attention to the Silicon Vertex Tracker detector, the most critical detector for the determination of decay vertices and thus of lifetimes and time dependent CP violation asymmetries. In the fourth chapter the operation and running of the vertex detector is described, as a result from the experience as Operation Manager of the SVT, with particular attention to the safety of the device and the data quality assurance. The last chapter is dedicated to the determination of the D{sup 0} meson lifetime with the BABAR detector, which is the main data analysis carried out by the candidate. The analysis is characterized by the selection of an extremely pure sample of D{sup 0} mesons for which the decay flight length and proper time is reconstructed. The description of the unbinned maximum likelihood fit follows, as well as the discussion of the possible sources of systematic uncertainties. In the appendix is also presented a preliminary study of a possible development regarding the determination of mixing and CP violation parameters for the D{sup 0} meson.

Simi, Gabriele; /Pisa U. /SLAC

2009-12-17T23:59:59.000Z

243

Politics, externalities, and risk: the regulation of chemical carcinogens  

SciTech Connect

Starting from the premise that the risk to human health posed by the production of potentially carcinogenic chemical compounds constitutes an externality, this dissertation examines the various mechanisms available to the political system for controlling cancer risks. Both governmental regulation and market-oriented economic incentive structures are evaluated for their effectiveness in reducing cancer risks. For reasons enumerated in the text, it was found that market-oriented strategies by themselves do not constitute an advantage over government regulation. However, a combination of direct regulation and a system of effluent charges adjusted to include the cost of anticipated harm could provide the optimal strategy for reducing cancer risks as well as for providing a mechanism for the compensation of victims.

Brandys, M.W.

1983-01-01T23:59:59.000Z

244

Guidelines for Carcinogen Risk Assessment  

NLE Websites -- All DOE Office Websites (Extended Search)

P-03/001F P-03/001F March 2005 Guidelines for Carcinogen Risk Assessment Risk Assessment Forum U.S. Environmental Protection Agency Washington, DC DISCLAIMER This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. CONTENTS 1. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-1 1.1. PURPOSE AND SCOPE OF THE GUIDELINES . . . . . . . . . . . . . . . . . . . . . . . . 1-1 1.2. ORGANIZATION AND APPLICATION OF THE GUIDELINES . . . . . . . . . . . 1-3 1.2.1. Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-3 1.2.2. Application . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-5 1.3. KEY FEATURES OF THE CANCER GUIDELINES .

245

Precision Measurements of Atomic Lifetimes and Hyperfine Energies in Alkali Like Systems  

Science Conference Proceedings (OSTI)

Financial support of this research project has lead to advances in the study of atomic structure through precision measurements of atomic lifetimes, energy splittings, and transitions energies. The interpretation of data from many areas of physics and chemistry requires an accurate understanding of atomic structure. For example, scientists in the fields of astrophysics, geophysics, and plasma fusion depend on transition strengths to determine the relative abundances of elements. Assessing the operation of discharges and atomic resonance line filters also depends on accurate knowledge of transition strengths. Often relative transition strengths are measured precisely, but accurate atomic lifetimes are needed to obtain absolute values. Precision measurements of atomic lifetimes and energy splittings also provide fundamentally important atomic structure information. Lifetimes of allowed transitions depend most strongly on the electronic wave function far from the nucleus. Alternatively, hyperfine splittings give important information about the electronic wave function in the vicinity of the nucleus as well as the structure of the nucleus. Our main focus throughout this project has been the structure of atomic cesium because of its connection to the study of atomic parity nonconservation (PNC). The interpretation of atomic PNC experiments in terms of weak interaction coupling constants requires accurate knowledge of the electronic wave function near the nucleus as well as far from the nucleus. It is possible to address some of these needs theoretically with sophisticated many-electron atomic structure calculations. However, this program has been able to address these needs experimentally with a precision that surpasses current theoretical accuracy. Our measurements also play the important role of providing a means for testing the accuracy of many-electron calculations and guiding further theoretical development, Atomic systems such as cesium, with a single electron outside of a closed shell, provide the simplest open shell systems for detailed comparisons between experiment and theory. This program initially focused on measurements of excited state atomic lifetimes in alkali atomic systems. Our first measurements of atomic lifetimes in cesium surpassed the precision and accuracy of previous measurements and sparked renewed interest in the need for greater precision in lifetime measurements throughout the atomic physics community. After enhancing the capabilities of the laser systems built for these initial measurements, we began a study hyperfine energy splittings in cesium using a thermal atomic beam. The results surpassed previous measurements by more than an order of magnitude and lead to the first observation of the nuclear magnetic octupole moment in cesium demonstrating the inadequacy of the nuclear shell model for predicting high order nuclear moments. The laser system and atomic beam apparatus developed for these endeavors turned out to be perfectly suited for exploring the possibility of making absolute optical frequency measurements of atomic transitions. We initiated collaboration with researchers at NIST so that the desired optical frequencies could be reference with respect to the primary microwave frequency standard (Cs atomic fountain NIST-FI) via a femtosecond laser frequency comb. Our first absolute optical frequency measurement, of the cesium D2 line, surpassed the accuracy of a previous measurement by more than an order of magnitude. An absolute optical frequency measurement of the cesium D1 line, now near completion, also surpasses previous results and places us in a position to be able to report a new value for the fine structure constant which is the fundamental dimensionless constant that underlies all electromagnetic interactions.

Tanner, Carol E.

2005-03-04T23:59:59.000Z

246

Quasars Are Not Light-Bulbs: Testing Models of Quasar Lifetimes with the Observed Eddington Ratio Distribution  

E-Print Network (OSTI)

We use the observed distribution of Eddington ratios as a function of supermassive black hole (BH) mass to constrain models of AGN lifetimes and lightcurves. Given the observed AGN luminosity function, a model for AGN lifetimes (time above a given luminosity) translates directly to a predicted Eddington ratio distribution. Models for self-regulated BH growth, in which feedback produces a 'blowout' decay phase after some peak luminosity (shutting down accretion) make specific predictions for the lifetimes distinct from those expected if AGN are simply gas starved (without feedback) and very different from simple phenomenological 'light bulb' models. Present observations of the Eddington ratio distribution, spanning 5 decades in Eddington ratio, 3 in BH mass, and redshifts z=0-1, agree with the predictions of self-regulated models, and rule out 'light-bulb', pure exponential, and gas starvation models at high significance. We compare the Eddington ratio distributions at fixed BH mass and fixed luminosity (both are consistent, but the latter are much less constraining). We present empirical fits to the lifetime distribution and show how the Eddington ratio distributions place tight limits on AGN lifetimes at various luminosities. We use this to constrain the shape of the typical AGN lightcurve, and provide simple analytic fits. Given independent constraints on episodic lifetimes, most local BHs must have gained their mass in no more than a couple of bright episodes, in agreement with merger-driven fueling models.

Philip F. Hopkins; Lars Hernquist

2008-09-22T23:59:59.000Z

247

Lifetime Response of a Hi-Nicalon Fiber-Reinforced Melt-Infiltrated SiC Matrix Composites  

DOE Green Energy (OSTI)

Lifetime studies in four-point flexure were performed on a Hi-NicalonTM fiber-reinforced SiC matrix composite over a temperature range of 700 degrees to 1150 degrees C in air. The composite consisted of ~40 vol. % Hi-NicalonTM fiber (8-harness weave) with a 0.5 Mu-m BN fiber coating and a melt-infiltration SiC matrix wand was tested with as-machined surfaces. Lifetime results indicated that the composite exhibited a stress-dependent lifetime at stress levels above an apparent fatigue limit, similar to the trend observed in CG-NicalonTM fiber reinforced CVI SiC matrix composites. At less than or equal to 950 degrees C, the lifetimes of Hi-Nicalon/MI SiC composites decreased with increasing applied stress level and test temperature. However, the lifetimes were extended as test temperature increased from 950 degees to 1150 degrees C as a result of surface crack sealing due to glass formation by the oxidation of Mi SiC matrix. The lifetime governing processes were, in general, attributed to the progressive oxidation of BN fiber coating and formation of glassy phase, which formed a strong bond between fiber and matrix, resulting in embrittlement of the composite with time.

Becher, P.F.; Lin, H.T.; Singh, M.

1999-04-25T23:59:59.000Z

248

Risk Management RM  

Energy.gov (U.S. Department of Energy (DOE))

This tool is the process of continuous and iterative identification and control of project risks and opportunities. Risks can be technical, financial, or programmatic. The goal for the risk...

249

Risk and robust optimization  

E-Print Network (OSTI)

This thesis develops and explores the connections between risk theory and robust optimization. Specifically, we show that there is a one-to-one correspondence between a class of risk measures known as coherent risk measures ...

Brown, David Benjamin, Ph. D. Massachusetts Institute of Technology

2006-01-01T23:59:59.000Z

250

Use of silicide fuel in the Ford Nuclear Reactor - to lengthen fuel element lifetimes  

SciTech Connect

Based on economic considerations, it has been proposed to increase the lifetime of LEU fuel elements in the Ford Nuclear Reactor by raising the {sup 235}U plate loading from 9.3 grams in aluminide (UAl{sub x}) fuel to 12.5 grams in silicide (U{sub 3}Si{sub 2}) fuel. For a representative core configuration, preliminary neutronic depletion and steady state thermal hydraulic calculations have been performed to investigate core characteristics during the transition from an all-aluminide to an all-silicide core. This paper discusses motivations for this fuel element upgrade, results from the calculations, and conclusions.

Bretscher, M.M.; Snelgrove, J.L. [Argonne National Lab., IL (United States); Burn, R.R.; Lee, J.C. [Univ. of Michigan, Ann Arbor, MI (United States). Phoenix Memorial Lab.

1995-12-31T23:59:59.000Z

251

Lifetimes of electronic excitations in unoccupied surface states and the image potential states on Pd(110)  

SciTech Connect

The contribution of inelastic electron-electron scattering to the decay rate of excitations in the surface states and first two image potential states at the Y-bar point on the surface is calculated in the GW approximation, and the quasi-momentum dependence of the corresponding contribution for the surface states is analyzed. The mechanisms of electron scattering in these states are studied, and the temperature dependence of the excitation lifetime is analyzed with allowance for the contribution of the electron-phonon interaction calculated earlier.

Tsirkin, S. S., E-mail: tsirkinss@gmail.com; Eremeev, S. V. [Tomsk State University (Russian Federation); Chulkov, E. V. [San Sebastian/Donostia, Donostia International Physics Center (DIPC) (Spain)

2012-10-15T23:59:59.000Z

252

Photo-degradation of Lexan polycarbonate studied using positron lifetime spectroscopy  

SciTech Connect

The free volume properties of pristine and UV irradiated Lexan polycarbonate have been investigated using Positron Lifetime Spectroscopy (PLS). The decrease in o-Ps life time and free volume size of irradiated sample is attributed to free volume modification and formation of more stable free radicals. These free radicals are formed due to the breakage of C-O bonds in Lexan polycarbonate after irradiation. This is also supported by the decrease in the intensity of C-O bond after exposure to UV-radiation as studied from Fourier Transform Infrared (FTIR) spectroscopy and it also shows that benzene ring does not undergo any changes after irradiation.

Hareesh, K.; Sanjeev, Ganesh [Microtron Centre, Department of Physics, Mangalore University, Mangalagangotri-574199 (India); Pandey, A. K. [Radiochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai-400085 (India); Meghala, D.; Ranganathaiah, C. [Department of Studies in Physics, University of Mysore, Manasagangotri-570006 (India)

2013-02-05T23:59:59.000Z

253

Measurement of the effective $B^0_s \\rightarrow K^+K^-$ lifetime  

E-Print Network (OSTI)

A measurement of the effective $B^0_s \\rightarrow K^+K^-$ lifetime is presented using approximately $37 pb^{-1}$ of data collected by LHCb during 2010. This quantity can be used to put constraints on contributions from processes beyond the Standard Model in the $B_s$ meson system and is determined by two complementary approaches as $\\tau_{B_s\\to K^+K^-} = 1.440 \\pm 0.096 (stat) \\pm 0.008 (syst) \\pm 0.003 (model) ps$.

Aaij, R; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amhis, Y; Anderson, J; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Arrabito, L; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Bailey, D S; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bates, A; Bauer, C; Bauer, Th; Bay, A; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blanks, C; Blouw, J; Blusk, S; Bobrov, A; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Brisbane, S; Britsch, M; Britton, T; Brook, N H; Brown, H; Büchler-Germann, A; Burducea, I; Bursche, A; Buytaert, J; Cadeddu, S; Caicedo Carvajal, J M; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Charles, M; Charpentier, Ph; Chiapolini, N; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Collins, P; Comerma-Montells, A; Constantin, F; Conti, G; Contu, A; Cook, A; Coombes, M; Corti, G; Cowan, G A; Currie, R; D'Almagne, B; D'Ambrosio, C; David, P; De Bonis, I; De Capua, S; De Cian, M; De Lorenzi, F; De Miranda, J M; De Paula, L; De Simone, P; Decamp, D; Deckenhoff, M; Degaudenzi, H; Deissenroth, M; Del Buono, L; Deplano, C; Derkach, D; Deschamps, O; Dettori, F; Dickens, J; Dijkstra, H; Diniz Batista, P; Domingo Bonal, F; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisele, F; Eisenhardt, S; Ekelhof, R; Eklund, L; Elsasser, Ch; d'Enterria, D G; Esperante Pereira, D; Estève, L; Falabella, A; Fanchini, E; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Fernandez Albor, V; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Frank, M; Frei, C; Frosini, M; Furcas, S; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garnier, J-C; Garofoli, J; Garra Tico, J; Garrido, L; Gascon, D; Gaspar, C; Gauvin, N; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Haefeli, G; Haen, C; Haines, S C; Hampson, T; Hansmann-Menzemer, S; Harji, R; Harnew, N; Harrison, J; Harrison, P F; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Holubyev, K; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Huston, R S; Hutchcroft, D; Hynds, D; Iakovenko, V; Ilten, P; Imong, J; Jacobsson, R; Jaeger, A; Jahjah Hussein, M; Jans, E; Jansen, F; Jaton, P; Jean-Marie, B; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Keaveney, J; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kim, Y M; Knecht, M; Koblitz, S; Koppenburg, P; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kruzelecki, K; Kucharczyk, M; Kumar, R; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Le Gac, R; van Leerdam, J; Lees, J-P; Lefévre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Li, L; Li Gioi, L; Lieng, M; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Luisier, J; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Magnin, J; Malde, S; Mamunur, R M D; Manca, G; Mancinelli, G; Mangiafave, N; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martin Sánchez, A; Martinez Santos, D; Massafferri, A; Mathe, Z; Matteuzzi, C; Matveev, M; Maurice, E; Maynard, B; Mazurov, A; McGregor, G; McNulty, R; Mclean, C; Meissner, M; Merk, M; Merkel, J; Messi, R; Miglioranzi, S; Milanes, D A; Minard, M-N; Monteil, S; Moran, D; Morawski, P; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Musy, M; Mylroie-Smith, J; Naik, P; Nakada, T; Nandakumar, R; Nardulli, J; Nasteva, I; Nedos, M; Needham, M; Neufeld, N; Nguyen-Mau, C; Nicol, M; Nies, S; Niess, V; Nikitin, N; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, K; Palacios, J; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C

2012-01-01T23:59:59.000Z

254

Excitation energies, polarizabilities, multipole transition rates, and lifetimes in Th IV  

E-Print Network (OSTI)

Excitation energies of the ns_{1/2} (n=7-10), np_j (n=7-9), nd_j (n=6-8), nf_{j} (n=5-7), and ng_{j} (n=5-6) states in Th IV are evaluated. First-, second-, third-, and all-order Coulomb energies and first- and second-order Coulomb-Breit energies are calculated. Reduced matrix elements, oscillator strengths, transition rates, and lifetimes are determined for the 96 possible nl_j-n'l'_j' electric-dipole transitions. Multipole matrix elements (7s_{1/2}-6d_j, 7s_{1/2}-5f_j, and 5f_{5/2}-5f_{7/2}) are evaluated to obtain the lifetimes of the $5f_{7/2}$ and 7s_{1/2}$ states. Matrix elements are calculated using both relativistic many-body perturbation theory, complete through third order, and a relativistic all-order method restricted to single and double (SD) excitations. Scalar and tensor polarizabilities for the 5f_{5/2} ground state in Th3+ are calculated using relativistic third-order and all-order methods. These calculations provide a theoretical benchmark for comparison with experiment and theory.

Safronova, U I; Safronova, M S

2006-01-01T23:59:59.000Z

255

Work at FNAL to achieve long electron drift lifetime in liquid argon  

SciTech Connect

This note records some of the work done between July 2005 and July 2006 to achieve long (many milliseconds) electron drift lifetimes in liquid argon at Fermilab. The work is part of a process to develop some experience at Fermilab with the technology required to construct a large liquid argon TPC. This technology has been largely developed by the ICARUS collaboration in Europe and this process can be seen as technology transfer. The capability to produce liquid argon in which electrons have drift lifetimes of several milliseconds is crucial to a successful device. Liquid argon calorimeters have been successfully operated at Fermilab; their electro-negative contaminants are at the level of 10{sup -7} while the TPC we are considering requires a contamination level at the level of 10{sup -11}, tens of parts per trillion (ppt). As well as demonstrating the ability to produce liquid argon at this level of purity, the work is part of a program to test the effect on the electron drift time of candidate materials for the construction of a TPC in liquid argon.

Finley, D.; Jaskierny, W.; Kendziora, C.; Krider, J.; Pordes, S.; Rapidis, P.A.; Tope, T.; /Fermilab

2006-10-01T23:59:59.000Z

256

Constraining cloud lifetime effects of aerosols using A-Train satellite observations  

Science Conference Proceedings (OSTI)

Aerosol indirect effects have remained the largest uncertainty in estimates of the radiative forcing of past and future climate change. Observational constraints on cloud lifetime effects are particularly challenging since it is difficult to separate aerosol effects from meteorological influences. Here we use three global climate models, including a multi-scale aerosol-climate model PNNL-MMF, to show that the dependence of the probability of precipitation on aerosol loading, termed the precipitation frequency susceptibility (S{sub pop}), is a good measure of the liquid water path response to aerosol perturbation ({lambda}), as both Spop and {lambda} strongly depend on the magnitude of autoconversion, a model representation of precipitation formation via collisions among cloud droplets. This provides a method to use satellite observations to constrain cloud lifetime effects in global climate models. S{sub pop} in marine clouds estimated from CloudSat, MODIS and AMSR-E observations is substantially lower than that from global climate models and suggests a liquid water path increase of less than 5% from doubled cloud condensation nuclei concentrations. This implies a substantially smaller impact on shortwave cloud radiative forcing (SWCF) over ocean due to aerosol indirect effects than simulated by current global climate models (a reduction by one-third for one of the conventional aerosol-climate models). Further work is needed to quantify the uncertainties in satellite-derived estimates of S{sub pop} and to examine S{sub pop} in high-resolution models.

Wang, Minghuai; Ghan, Steven J.; Liu, Xiaohong; Ecuyer, Tristan L.; Zhang, Kai; Morrison, H.; Ovchinnikov, Mikhail; Easter, Richard C.; Marchand, Roger; Chand, Duli; Qian, Yun; Penner, Joyce E.

2012-08-15T23:59:59.000Z

257

Spatiotemporal and spatial threshold models for relating UV exposures and skin cancer in the central United States  

Science Conference Proceedings (OSTI)

The exact mechanisms relating exposure to ultraviolet (UV) radiation and elevated risk of skin cancer remain the subject of debate. For example, there is disagreement on whether the main risk factor is duration of the exposure, its intensity, or some ...

Laura A. Hatfield; Richard W. Hoffbeck; Bruce H. Alexander; Bradley P. Carlin

2009-06-01T23:59:59.000Z

258

Application and modeling of frequency-domain lifetime spectroscopy for microsphere-based optical glucose sensors  

E-Print Network (OSTI)

A new glucose affinity sensor based on a homogeneous fluorescence resonance energy transfer (FRET) assay system was developed to monitor the competitive binding between concanavalin A (ConA) and dextran. The FRET quenching kinetics of the donor were analyzed from frequency-domain (FD) measurements as functions of both glucose and acceptor-protein concentrations using a Förster-type decay kinetics model. The results showed that the FD measurements and donor decay kinetics can indicate quantitative changes in the presence of glucose at concentrations ranging from 0 to 224 mg/dL. The second set of experiments proved the feasibility of performing analyte sensing with FD lifetime spectroscopy using microsphere-based sensors in multiple scattering solutions. A well characterized pH-sensitive fluorophore was entrapped in poly(ethylene glycol) microspheres. The particles were then immersed in a buffered polystyrene solution of various pH. Measurements of phase shift and modulation of the generated and multiply scattered fluorescent light were acquired as the modulation frequency of the incident excitation light varied from 10 to 120 MHz. After the measured data were analyzed with the coupled diffusion equations, the obtained lifetimes from the scattering measurements matched values from non-scattering measurements. Lastly, a new two-speed Monte Carlo (MC) simulation was developed to predict light propagation through the sensors and thus was used to evaluate these sensors and to design these sensors for implantation. The model used random packing structure and considered geometric optics and two light propagation speeds. Experimental measurements of phase-shift and modulation of excitation light were made on a cubic phantom with non-fluorescent resin microspheres of 74 µm diameter, and compared to those computed from the MC simulation. The results showed that the mean phase shift (PS) deviation was 0.736° and the mean amplitude deviation was 42%. Quantitative changes in detected fluorescence phase-shift and modulation were investigated for microsphere diameter, volume fraction, refractive index, and fluorophore lifetime. We also found that even though the sensitivity of PS change in the presence of scattering was the same as the value without scattering, the values of PS were magnified due to the scattering effects.

Liang, Feng

2006-12-01T23:59:59.000Z

259

The carcinogenic risks of low-LET and high-LET ionizing radiations  

SciTech Connect

New information is available concerning the carcinogenic effects of radiation and the implications for risk assessment and risk management. This information comes from further follow-up of the epidemiological studies of the Japanese atomic bomb survivors, patients irradiated medically for cancer and allied conditions, and workers exposed in various occupations. In the Japanese atomic bomb survivors the carcinogenic risks are estimated to be somewhat higher than previously, due to the reassessment of the atomic-bomb dosimetry, further follow-up with increase in the number of excess cancer deaths, particularly in survivors irradiated early in life, and changes in the methods of analysis to compute the age-specific risks of cancer. Because of the characteristics of the atomic bomb survivor series as regards sample size, age and sex distribution, duration for follow-up, person-years at risk, and type of dosimetry, the mortality experience of the atomic bomb survivors was selected by the UNSCEAR Committee and the BEIR V Committee as the more appropriate basis for projecting risk estimates for the general population. In the atomic bomb survivors, the dose-effect relationship for overall cancer mortality other than leukemia is consistent with linearity below 3 Gy, while the dose-effect relationship for leukemia, excluding chronic lymphatic leukemia, conforms best to a linear-quadratic function. The shape of the dose-incidence curve at low doses still remains uncertain, and the data do not rule out the possible existence of a threshold for an neoplasm. The excess relative risk of mortality from all cancers combined is estimated to be 1.39 per Gy (shielded kerma), which corresponds to an absolute risk of 10.0 excess cancer deaths per 10,000 PYGy; the relative risks is 1.41 at 1 Gy (organ-absorbed dose), and an absolute risk of 13.07 excess cancer deaths per 10,000 PYGy. 19 refs.

Fabrikant, J.I. (Lawrence Berkeley Lab., CA (USA))

1989-08-01T23:59:59.000Z

260

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

Risk Assessment Documents Risk Assessment Documents ORNL RA Graphic Results ORNL Baseline Risk Assessment Results ORNL Screening Risk Assessment Results ORNL Other Risk Assessment Results ORNL RA Graphic Results WAG 2 Residential Landuse Sediment - Total Risk Sediment - Cesium 137 Risk Sediment - Cobalt 60 Risk Surface Water - Total Hazard Surface Water - Total Risk Surface Water - Strontium 90 Risk Surface Water - Tritium Risk Recreational Landuse Sediment - Total Risk Sediment - Cesium 137 Risk Sediment - Cobalt 60 Risk Surface Water - Total Hazard Surface Water - Total Risk Surface Water - Strontium 90 Risk Surface Water - Tritium Risk Recreational Landuse (No Fish) Surface Water - Total Hazard Surface Water - Total Risk Surface Water - Strontium 90 Risk Surface Water - Tritium Risk Industrial Landuse

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Quasars Are Not Light-Bulbs: Testing Models of Quasar Lifetimes with the Observed Eddington Ratio Distribution  

E-Print Network (OSTI)

We use the observed distribution of Eddington ratios as a function of supermassive black hole (BH) mass to constrain models of AGN lifetimes and lightcurves. Given the observed AGN luminosity function, a model for AGN lifetimes (time above a given luminosity) translates directly to a predicted Eddington ratio distribution. Models for self-regulated BH growth, in which feedback produces a 'blowout' decay phase after some peak luminosity (shutting down accretion) make specific predictions for the lifetimes distinct from those expected if AGN are simply gas starved (without feedback) and very different from simple phenomenological 'light bulb' models. Present observations of the Eddington ratio distribution, spanning 5 decades in Eddington ratio, 3 in BH mass, and redshifts z=0-1, agree with the predictions of self-regulated models, and rule out 'light-bulb', pure exponential, and gas starvation models at high significance. We compare the Eddington ratio distributions at fixed BH mass and fixed luminosity (both ...

Hopkins, Philip F

2008-01-01T23:59:59.000Z

262

Theory and models of material erosion and lifetime during plasma instabilities in a tokamak environment.  

SciTech Connect

Surface and structural damage to plasma-facing components (PFCs) due to the frequent loss of plasma confinement remains a serious problem for the tokamak reactor concept. The deposited plasma energy causes significant surface erosion, possible structural failure, and frequent plasma contamination. Surface damage consists of vaporization, spallation, and liquid splatter of metallic materials. Structural damage includes large temperature increases in structural materials and at the interfaces between surface coatings and structural members. To evaluate the lifetimes of plasma-facing materials and nearby components and to predict the various forms of damage that they experience, comprehensive models (contained in the HEIGHTS computer simulation package) are developed, integrated self-consistently, and enhanced. Splashing mechanisms such as bubble boiling and various liquid magnetohydrodynamic instabilities and brittle destruction mechanisms of nonmelting materials are being examined. The design requirements and implications of plasma-facing and nearby components are discussed, along with recommendations to mitigate and reduce the effects of plasma instabilities on reactor components.

Hassanein, A.; Konkashbaev, I.

1999-11-08T23:59:59.000Z

263

PREDICTION OF DISSOLVER LIFETIMES THROUGH NON-DESTRUCTIVE EVALUATION AND LABORATORY TESTING  

Science Conference Proceedings (OSTI)

Non-destructive evaluation was used as the primary method of monitoring the corrosion degradation of nuclear material dissolvers and assessing the remaining lifetimes. Materials were typically processed in nitric acid based (4-14M) solutions containing fluoride concentrations less than 0.2 M. The primary corrosion issue for the stainless steel dissolvers is the occurrence of localized corrosion near the tank bottom and the heat affected zones of the welds. Laboratory data for a range of operational conditions, including solution chemistry and temperature, was used to assess the impact of processing changes on the dissolver corrosion rate. Experimental and NDE-based general corrosion rates were found to be in reasonable agreement for standard dissolution chemistries consisting of nitric acid with fluorides and at temperatures less than 95 C. Greater differences were observed when chloride was present as an impurity and temperatures exceeded 100 C.

Mickalonis, J.; Woodsmall, T.; Hinz, W.; Edwards, T.

2011-10-03T23:59:59.000Z

264

Lifetime Measurement of the 2{sub 1}{sup +} State in {sup 20}C  

Science Conference Proceedings (OSTI)

Establishing how and when large N/Z values require modified or new theoretical tools is a major quest in nuclear physics. Here we report the first measurement of the lifetime of the 2{sub 1}{sup +} state in the near-dripline nucleus {sup 20}C. The deduced value of {tau}{sub 2{sub 1}{sup +}}=9.8{+-}2.8(stat){sub -1.1}{sup +0.5}(syst) ps gives a reduced transition probability of B(E2;2{sub 1}{sup +}{yields}0{sub g.s.}{sup +})=7.5{sub -1.7}{sup +3.0}(stat){sub -0.4}{sup +1.0}(syst) e{sup 2} fm{sup 4} in good agreement with a shell model calculation using isospin-dependent effective charges.

Petri, M.; Fallon, P.; Macchiavelli, A. O.; Paschalis, S.; Clark, R. M.; Cromaz, M.; Gros, S.; Jeppesen, H. B.; Lee, I. Y. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Starosta, K. [Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6 (Canada); National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824 (United States); Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824 (United States); Baugher, T.; Gade, A.; McDaniel, S.; Miller, D.; Ratkiewicz, A.; Voss, P.; Walsh, K. A. [National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824 (United States); Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824 (United States); Bazin, D.; Grinyer, G. F.; Weisshaar, D. [National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824 (United States)

2011-09-02T23:59:59.000Z

265

EFFECTIVE LIFETIME ESTIMATE OF CRIMPED POWERLINE SPLICE CONNECTOR OPERATED AT HIGH TEMPERATURE  

SciTech Connect

This paper addresses the thermal-mechanical properties and performance characteristics of full tension splice connectors under high temperature operation, in particular those used in overhead transmission and distribution lines. Due to the increase in power demand existing overhead power transmission lines often need to operate at temperatures higher than those originally considered for their design. This has led to the accelerated aging and degradation of splice connectors. The compressive residual stresses induced by the crimping process within the splice connector provide the clamping forces to secure the conductor and therefore, the determination of the state of compressive residual stresses in splice connectors is a necessary requirement to provide an accurate estimate of their service lifetime. This paper presents a protocol for integrating analytical and experimental approaches to evaluate the integrity of a full tension single-stage splice connector assembly.

Wang, Jy-An John [ORNL; Lara-Curzio, Edgar [ORNL; King Jr, Thomas J [ORNL; An, Ke [ORNL; Hubbard, Camden R [ORNL

2008-01-01T23:59:59.000Z

266

Norwegian National Program for Lifetime Commissioning and Energy Efficient Operation of Buildings  

E-Print Network (OSTI)

The project “Life-Time Commissioning for Energy Efficient Operation of Buildings” is actually a network of industrial companies, private and public entities, and R&D organizations. The overall objective of the project is to contribute to the implementation of life-long commissioning of building HVAC systems, so that this becomes a standardized way of building, operating and maintaining the HVAC systems in Norway. The project is organized as an industry research program with minimum duration of five years. Project members pay an annual membership fee. The main goal for the project is to develop, verify, document and implement suitable tools for functional control of energy and indoor environment in buildings under continuous operation during the entire operational life of the building. This will improve energy efficiency and ensure a rational use of energy and a sound indoor environment. All achievements concerning energy improvement will also contribute to the decrease of CO2 emissions.

Novakovic, V.; Djuric, N.; Holst, J.; Frydenlund, F.

2006-01-01T23:59:59.000Z

267

What is the probability that radiation caused a particular cancer  

SciTech Connect

Courts, lawyers, health physicists, physicians, and others are searching for a credible answer to the question posed in the title of this paper. The cases in which the question arises frequently stem from an individual that has cancer and they, or their next-of-kin, are convinced that a past radiation exposure - usually small - is responsible for causing it. An arithmetic expression of this problem is simple: the probability of causation by the radiation dose in question is equal to the risk of cancer from the radiation dose divided by the risk of cancer from all causes. The application of risk factors to this equation is not so simple. It must involve careful evaluation of the reliability of and variations in risk coefficients for development of cancer due to radiation exposure, other carcinogenic agents, and natural causes for the particular individual. Examination of our knowledge of these various factors indicates that a large range in the answers can result due to the variability and imprecision of the data. Nevertheless, the attempts to calculate and the probability that radiation caused the cancer is extremely useful to provide a gross perspective on the probability of causation. It will likely rule in or out a significant number of cases despite the limitations in our understandings of the etiology of cancer and the risks from various factors. For the remaining cases, a thoughtful and educated judgment based on selected data and circumstances of the case will also be needed before the expert can develop and support his opinion.

Voelz, G.L.

1983-01-01T23:59:59.000Z

268

An overview of the United States Department of Energy plant lifetime improvement program  

Science Conference Proceedings (OSTI)

Today, 109 nuclear power plants provide over 20 percent of the electrical energy generated in the US. The operating license of the first of these plants will expire in the year 2000; one third of the operating licenses will expire by 2010 and the remaining plant licenses are scheduled to expire by 2033. The National Energy Strategy assumes that 70 percent of these plants will continue to operate beyond their current license expiration to assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth. In order to preserve this energy resource in the US three major tasks must be successfully completed: (1) establishment of the regulations, technical standards, and procedures for the preparation and review of a license renewal application; (2) development, verification, and validation of the various technical criteria and bases for needed monitoring, refurbishment, or replacement of plant equipment; and (3) demonstration of the regulatory process. Since 1985, the US Department of Energy (DOE) has been working with the nuclear industry and the US Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of nuclear power plants through the renewal of operating licenses. This paper focuses primarily on DOE`s Plant Lifetime Improvement (PLIM) Program efforts to develop the technical criteria and bases for effective aging management and lifetime improvement for continued operation of nuclear power plants. This paper describes current projects to resolve generic technical issues, including degradation of long-lived components, reactor pressure vessel (RPV) embrittlement management approaches, and analytical methodologies to characterize RPV integrity.

Rosinski, S.T.; Clauss, J.M. [Sandia National Labs., Albuquerque, NM (United States); Harrison, D.L. [USDOE, Washington, DC (United States)

1993-08-01T23:59:59.000Z

269

Environmental Health & Safety Risk Categories for EH&S Laboratory Inspections  

E-Print Network (OSTI)

and safety certification Training/ SOPs Risk Category Training and Procedure Requirements Level 1 - Requires Revised 01/11/2011 "Carcinogens" are chemicals which cause cancer. For the purpose of the CHP, chemicals

Elser, Jim

270

REACTIVITY LIFETIME 5091.4-5806.1 EFPH. CORE I, SEED 1. Test Results T- 612118-B  

SciTech Connect

The Shippingport Atomic Power Station was operated for 715 EFPH from Ang. 11 to Oct. 7, 1959, in order to determine the performance characteristics reliability, stability, and lifetime variation of the core during rated power operation for an extended period of time. The plant was operated at successively lower power levels of 60, 43, and 17 Mwe to extend the Core I, Seed 1 lifetime. Logs and tables are included which present the events and all recorded data in this period. (D.L.C.)

1960-08-01T23:59:59.000Z

271

LPP Risk Management Plan  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

History and Process History and Process Slide 2 M E Environmental Management Environmental Management History â—¦ Current Baseline Process Overview â—¦ Identification â—¦ Simulation â—¦ Management Successes & Challenges Slide 3 M E Environmental Management Environmental Management Current Baseline Risks â—¦ 1 Week Risk Summit held week of August 4 th , 2008 Broad representation from all levels of Isotek, DOE, PTC, and outside consultants Focused on risk and opportunity identification Included risk description, assumptions, and triggers No quantification or analysis No restrictions, constraints, or filtering HQ provided facilitator Prescribed format and capture methodology Slide 4 M E Environmental Management Environmental Management Current Baseline Risks â—¦ Risk Summit Results

272

Commentary Breast cancer and childhood anthropometry: emerging hypotheses?  

E-Print Network (OSTI)

In this issue of Breast Cancer Research, Baer and colleagues report a strong protective effect of childhood and adolescent body fatness on premenopausal breast cancer risk based on a large prospective study. Methodological issues are discussed, as are tentative biological interpretations regarding the findings. In this issue of Breast Cancer Research, Baer and colleagues [1] report a strong protective effect of childhood and adolescent body fatness on premenopausal breast cancer risk. The report is based on the Nurses ’ Health Study II, a prospective cohort study including 116,671 US female nurses, aged 25–42 years at recruitment in 1989, in which 1318 breast cancer cases occurred during 12 years of follow up. There were slightly stronger associations between average childhood and adolescent body fatness and

Cecilia Mk Magnusson; Andrew W Roddam

2005-01-01T23:59:59.000Z

273

Evaluation of Lifetime of High Efficiency Organic Photovoltaic Devices: Cooperative Research and Development Final Report, CRADA Number CRD-10-379  

DOE Green Energy (OSTI)

As a part of this joint work, Solarmer and NREL will investigate the lifetime and stability of Organic Photovoltaic Devices based on Solarmer high efficiency active layer materials.

Olson, D.

2013-04-01T23:59:59.000Z

274

Risk Assess - updated  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Software Development Risk Assessment Software Development Risk Assessment Note: The purpose of this prompt list is to provide project managers with a tool for identifying and planning for potential project risks. It is process-based and supports the framework established by the DOE Software Engineering Methodology. It will be used within the stage exit process as an additional tool to ensure that the project manager has identified and is managing known risk factors. Additional detailed information describes the various risk factors and how to score them. Performing a risk assessment is an important step in being prepared for potential problems that can occur within any software project. During the risk assessment, if a potential risk is identified, a solution or plan of action should be developed. (A problem analyzed and planned

275

Anodic dissolution characteristics and electrochemical migration lifetimes of Sn solder in NaCl and Na2SO4 solutions  

Science Conference Proceedings (OSTI)

In situ water drop tests and anodic polarization tests of pure Sn solder were carried out in deaerated 0.001% NaCl and Na"2SO"4 solutions to determine the correlation between anodic dissolution characteristics and the electrochemical migration lifetime. ... Keywords: Anodic dissolution, Electrochemical migration, Life time, Na2SO4, NaCl, Sn solder

Ja-Young Jung; Shin-Bok Lee; Young-Chang Joo; Ho-Young Lee; Young-Bae Park

2008-07-01T23:59:59.000Z

276

Algorithm for equalization of cluster lifetimes in a multi-level Beacon enabled 802.15.4 sensor network  

Science Conference Proceedings (OSTI)

We consider the problem of maintaining the prescribed event sensing reliability while maximizing cluster and network lifetime in a multi-cluster 802.15.4 sensor network. Clusters are connected through bridges which also act as cluster coordinators; both ... Keywords: IEEE 802.15.4, Power management, Sensor networks

Jelena Miši?

2007-08-01T23:59:59.000Z

277

Strength and Lifetime Analysis of SMT Solder Joints: An Exemplary Study of the MiniMELF Component  

E-Print Network (OSTI)

-linear three-dimensional finite element (FE) analysis of the thermally loaded struc- ture. In the present case by using the CAD software I-DEAS [2]. To allow for a swift and reliable stress / strain analysis including626 Strength and Lifetime Analysis of SMT Solder Joints: An Exemplary Study of the Mini

Berlin,Technische Universität

278

The Effects of a Hydrogen Environment on the Lifetime of Small-Diameter Drift Chamber Anode Wires  

DOE Green Energy (OSTI)

Possible deterioration of anode sense wires used in a hydrogen-filled neutron detector is investigated. Wires were loaded with free weights and put into a wire detector environment. Stainless Steel, Tungsten, and Platinum wires did not break after exposure to charge equivalent to many wire lifetimes. Furthermore, exposure to hydrogen gas caused no noticeable surface degradation or change in wire yield strength.

King, J; Smith, T; Kunkle, J; Castelaz, J; Thomson, S; Burstein, Z; Bernstein, A; Rosenberg, L; Hefner, M

2005-04-29T23:59:59.000Z

279

Cancer incidence in atomic bomb survivors. Part IV: Comparison of cancer incidence and mortality  

SciTech Connect

This report compares cancer incidence and mortality among atomic bomb survivors in the Radiation Effects Research Foundation Life Span Study (LSS) cohort. Because the incidence data are derived from the Hiroshima and Nagasaki tumor registries, case ascertainment is limited to the time (1958-1987) and geographic restrictions (Hiroshima and Nagasaki) of the registries, whereas mortality data are available from 1950-1987 anywhere in Japan. With these conditions, there were 9,014 first primary incident cancer cases identified among LSS cohort members compared with 7,308 deaths for which cancer was listed as the underlying cause of death on death certificates. When deaths were limited to those occurring between 1958-1987 in Hiroshima or Nagasaki, there were 3,155 more incident cancer cases overall, and 1,262 more cancers of the digestive system. For cancers of the oral cavity and pharynx, skin, breast, female and male genital organs, urinary system and thyroid, the incidence series was at least twice as large as the comparable mortality series. Although the incidence and mortality data are dissimilar in many ways, the overall conclusions regarding which solid cancers provide evidence of a significant dose response generally confirm the mortality findings. When either incidence or mortality data are evaluated, significant excess risks are observed for all solid cancers, stomach, colon, liver (when it is defined as primary liver cancer or liver cancer not otherwise specified on the death certificate), lung, breast, ovary and urinary bladder. No significant radiation effect is seen for cancers of the pharynx, rectum, gallbladder, pancreas, nose, larynx, uterus, prostate or kidney in either series. There is evidence of a significant excess of nonmelanoma skin cancer in the incidence data, but not in the mortality series. 19 refs., 2 figs., 10 tabs.

Ron, E. (Radiation Effects Research Foundation, Hiroshima (Japan) National Cancer Institute, Bethesda, MD (United States)); Preston, D.L.; Mabuchi, Kiyohiko (Radiation Effects Research Foundation, Hiroshima (Japan)); Thompson, D.E. (Radiation Effects Research Foundation, Hiroshima (Japan) George Washington Univ., Rockville, MD (United States) Radiation Effects Research Foundation, Nagasaki (Japan)); Soda, Midori (Radiation Effects Research Foundation, Nagasaki (Japan))

1994-02-01T23:59:59.000Z

280

Former Worker Program - Early Lung Cancer Detection Program  

NLE Websites -- All DOE Office Websites (Extended Search)

Former Worker Program (FWP) Former Worker Program (FWP) Home Covered Sites/Populations › Construction Worker Screening Projects › Production Worker Screening Projects › Supplemental Screening Program › Beryllium Vendor Screening Program Upcoming Events Program Implementation Outreach Medical Screening - Conventional Medical Screening - Early Lung Cancer Detection Communicating Results Protecting Participant Information Sharing De-identified Data Chronic Beryllium Disease Awareness Joint Outreach Task Group (JOTG) Worker Testimonials Contact Us FWP Scientific Publications FWP Documents Related Links Office of Health and Safety Home Page HSS Logo Early Lung Cancer Detection Program Former Worker Medical Screening Program (FWP) Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer. Through the FWP, DOE initiated the Early Lung Cancer Detection (ELCD) program using low-dose helical CT scans to detect lung cancers at an earlier, more treatable stage. Lung cancer results in about 160,000 deaths in the U.S. every year. The most common causes of lung cancer are long-term exposures to tobacco smoke and residential radon emissions, but occupational hazards, such as asbestos and ionizing radiation, also cause or contribute to the disease.

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

Technical Memorandum , Part II. Screening Level Risk Assessment 92-225-161-49 K-33 Cooling Towers screening risk assessments (2) K-770 sites screening risk assessment (9...

282

Screening Risk Evaluation methodology  

Science Conference Proceedings (OSTI)

The Screening Risk Evaluation (SRE) Guidance document is a set of guidelines provided for the uniform implementation of SREs performed on D&D facilities. These guidelines are designed specifically for the completion of the second (semi-quantitative screening) phase of the D&D Risk-Based Process. The SRE Guidance produces screening risk scores reflecting levels of risk through the use of risk ranking indices. Five types of possible risk are calculated from the SRE: current releases, worker exposures, future releases, physical hazards, and criticality. The Current Release Index (CRI) calculates the risk to human health and the environment from ongoing or probable releases within a one year time period. The Worker Exposure Index (WEI) calculates the risk to workers, occupants, and visitors in D&D facilities of contaminant exposure. The Future Release Index (FRI) calculates the risk of future releases of contaminants, after one year, to human health and the environment. The Physical Hazards Index (PHI) calculates the risk-to human health due to factors other than that of contaminants. The index of Criticality is approached as a modifying factor to the entire SRE, due to the fact that criticality issues are strictly regulated under DOE. Screening risk results will be tabulated in matrix form and Total Risk will be calculated (weighted equation) to produce a score on which to base early action recommendations. Other recommendations from the screening risk scores will be made based either on individual index scores or from reweighted Total Risk calculations. All recommendations based on the SRE will be made based on a combination of screening risk scores, decision drivers, and other considerations, determined on a project by project basis. The SRE is the first and most important step in the overall D&D project level decision making process.

Hopper, K.M. [Midwest Technical, Inc., Oak Ridge, TN (United States)

1994-06-01T23:59:59.000Z

283

Acceptability of risk from radiation: Application to human space flight  

SciTech Connect

This one of NASA`s sponsored activities of the NCRP. In 1983, NASA asked NCRP to examine radiation risks in space and to make recommendations about career radiation limits for astronauts (with cancer considered as the principal risk). In conjunction with that effort, NCRP was asked to convene this symposium; objective is to examine the technical, strategic, and philosophical issues pertaining to acceptable risk and radiation in space. Nine papers are included together with panel discussions and a summary. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

1997-04-30T23:59:59.000Z

284

Cancer in atomic bomb survivors  

SciTech Connect

Radiation carcinogenesis was first noted in studies of individuals with occupational or therapeutic exposure to radiation. Data from long-term follow-up studies of atomic bomb survivors in Hiroshima and Nagasaki have greatly enhanced our knowledge of radiation carcinogenesis. This book presents current results obtained from epidemiological studies and pathological studies on cancer among atomic bomb survivors. It includes a description of the dosimetry system which is currently being revised. Although many of the details about radiation carcinogenesis remain unknown or uncertain, it is clear that the incidence of radiation-induced cancer among atomic bomb survivors continues unabated 40 years after exposure. Recent increases in occupational and environmental exposure to radiation together with the need for a thorough review of radiation protection standards have led to increased recognition of the importance of research on radiation carcinogenesis and risk assessment.

Shigematsu, I.; Kagan, A.

1986-01-01T23:59:59.000Z

285

Air pollution and lung cancer  

SciTech Connect

Epidemiological evidence proves conclusively that lung cancer correlates with air pollution. However, data on lung cancer death rates and smoking show that mankind accepts the risk of long-term and low-level exposure to carcinogens. As a rule, immediate benefits are sought and remote hazards ignored. Fear of atmospheric contamination by radioactive fallout seems to be the main factor for awareness of air pollution. Experimental works help us to understand physics of particle deposition in the lungs (inertial impactation, sedimentation, Brownian movement), shed light on carcinogenesis (eg, bay region theory in case of polycyclic aromatic hydrocarbons and surface charge changes regarding asbestos), show that atmospheric particulates accepted as harmless may act as co-carcinogens (eg, iron and benzo(a)pyrene) and stress the importance of in vitro research (bacterial mutation tests, organ cultures, sister chromatid exchange system) to screen pollutants for their malignant potential and study their pathogenesis.

Boehm, G.M.

1982-01-01T23:59:59.000Z

286

Efficient Charging of Supercapacitors for Extended Lifetime of Wireless Sensor Nodes”,in  

E-Print Network (OSTI)

Abstract—This paper describes an efficient charging method for a supercapacitor-operated, solar-powered wireless sensor node called Everlast. Unlike traditional wireless sensors that store energy in batteries, Everlast’s use of supercapacitors enables the system to operate for an estimated lifetime of 20 years without any maintenance. The novelty of this system lies in the feed-forward, pulse frequency modulated converter and open-circuit solar voltage method for maximum power point tracking (MPPT), enabling the solar cell to efficiently charge the supercapacitor and power the node. Experimental results show that by its low-complexity MPPT, Everlast can achieve over 89 % conversion efficiency with lower power overhead than the state-of-the-art by two orders of magnitude, while enabling charging a supercapacitor up to 400 % faster than direct charging. This makes Everlast particularly applicable to miniature-scale, high-impedance energy harvesting systems. Index Terms—Energy harvesting, maximum power point tracking (MPPT), solar power, supercapacitor, wireless sensor node (WSN). I.

Farhan I. Simjee; Pai H. Chou

2008-01-01T23:59:59.000Z

287

Blackbody radiation shift, multipole polarizabilities, oscillator strengths, lifetimes, hyperfine constants, and excitation energies in Ca+  

E-Print Network (OSTI)

A systematic study of Ca+ atomic properties is carried out using high-precision relativistic all-order method where all single, double, and partial triple excitations of the Dirac-Fock wave functions are included to all orders of perturbation theory. Reduced matrix elements, oscillator strengths, transition rates, and lifetimes are determined for the levels up to n = 7. Recommended values and estimates of their uncertainties are provided for a large number of electric-dipole transitions. Electric-dipole scalar polarizabilities for the 5s, 6s, 7s, 8s, 4p, 5p, 3d, and 4d states and tensor polarizabilities for the 4p, 5p, 3d, and 4d states in Ca+ are calculated. Methods are developed to accurately treat the contributions from highly-excited states, resulting in significant (factor of 3) improvement in accuracy of the 3d_{5/2} static polarizability value, 31.8(3) a.u., in comparison with the previous calculation [Arora et al., Phys. Rev. A 76, 064501 (2007)]. The blackbody radiation (BBR) shift of the 4s - 3d_{5/...

Safronova, M S

2010-01-01T23:59:59.000Z

288

Spectroscopy and lifetime measurements of states in {sup 76}Kr populated in {sup 76}Rb decay  

SciTech Connect

The properties of the excited states of {sup 76}Kr, populated in the decay of {sup 76}Rb produced at ISOLDE isotopic separator, have been investigated by using K-conversion electron, {gamma}-ray, and {gamma}-{gamma} coincidence measurements. The lifetimes of several levels have been measured by means of the advanced time-delayed {beta}{gamma}{gamma}(t) method. The identification of 19 new levels and 55 transitions and the information deduced on spin and/or parity of the observed states from K-conversion coefficients, log ft values and decay properties have led to an improved knowledge of the level scheme. In particular, six 1{sup -} states have been definitely identified and J{sup {pi}}=2{sup -} has been assigned to the 2227 keV level, on which a band proposed to have negative-parity and even-spin had been previously observed. The strengths of the E0 and E2 transitions deexciting the 0{sub 2}{sup +} and 0{sub 3}{sup +} states (the latter is here identified with the state at 1598 keV) have been measured. The experimental data concerning the 0{sub 2}{sup +} state have been analyzed in a simple two states mixing model and in the framework of the proton-neutron interacting boson model.

Giannatiempo, A.; Perego, A.; Sona, P.; Nannini, A.; Mach, H.; Fogelberg, B.; Borge, M.J.G.; Tengblad, O.; Fraile, L.M.; Aas, A.J.; Gulda, K. [Dipartimento di Fisica, Universita di Firenze and Istituto Nazionale di Fisica Nucleare, Florence (Italy); Istituto Nazionale di Fisica Nucleare, Florence (Italy); Department of Radiation Sciences, University of Uppsala, S-75121 Uppsala (Sweden); Instituto 'Estructura de la Materia' Consejo Superior de Investigaciones Cientificas, Madrid (Spain); McKinsey and Company, Oslo (Norway); Ministry of Economic Affairs and Labour Department of Innovation, Warsaw (Poland)

2005-10-01T23:59:59.000Z

289

Study of the B-Meson Lifetime and the Performance of the Outer Tracker at LHCb  

E-Print Network (OSTI)

The research in the dissertation addresses two issues: the overall performance of the LHCb Outer Tracker (OT) detectors as shown during quality checks and beam tests; the study of the lifetimes of B+ and B0 mesons at LHCb. Physics at the Large Hadron Collider (LHC) at CERN, Geneva requires high performance detectors. One of the four major LHC experiments is the Large Hadron Collider beauty experiment (LHCb). It is a dedicated B-physics experiment for precision measurements of CP violation in the B-meson system and for studying rare B decays. In order to efficiently reconstruct the trajectories of charged particles, LHCb is equipped with Outer Tracker (OT), consisting of gaseous straw tube detectors. The OT system comprises three stations each consisting of multiple layers of wires in vertical and non-vertical orientation. Basic unit of the stations is the OT module - a self-contained gas-detector unit filled with a counting gas mixture. The outer tracker module production was carefully monitored by variety of...

Vankov, P

2008-01-01T23:59:59.000Z

290

Recovery Act: Low-Cost, Highly Lambertian Reflector Composite For Improved LED Fixture Efficiency and Lifetime  

SciTech Connect

The overall objective of the program was to demonstrate a 98% or greater reflective, highly diffuse, low-cost composite material that significantly improves luminaire efficiency, is able to withstand 50,000 hours or greater luminaire operation under expected LED system thermal and environmental operating extremes and meets the cost targets required to be an effective commercial solution for the Solid State Lighting industry. This project met most of the goals defined and contributed to the understanding of high reflectance, white coatings. Research under this program increased the understanding of coatings development using particle size reduction techniques and preparation of coating solutions with a broad range of particle types. The research explored scale-up of coating systems and generated understanding of processing required for high volume manufacturing applications. The work demonstrated how coating formulation and application technique can translate to material durability and LED system lifetime. The research also demonstrated improvements in lighting efficiency to be gained using high reflectance white coatings.

Teather, Eric

2013-02-15T23:59:59.000Z

291

Comparison of Minority Carrier Lifetime Measurements in Superstrate and Substrate CdTe PV Devices: Preprint  

DOE Green Energy (OSTI)

We discuss typical and alternative procedures to analyze time-resolved photoluminescence (TRPL) measurements of minority carrier lifetime (MCL) with the hope of enhancing our understanding of how this technique may be used to better analyze CdTe photovoltaic (PV) device functionality. Historically, TRPL measurements of the fast recombination rate (t1) have provided insightful correlation with broad device functionality. However, we have more recently found that t1 does not correlate as well with smaller changes in device performance, nor does it correlate well with performance differences observed between superstrate and substrate CdTe PV devices. This study presents TRPL data for both superstrate and substrate CdTe devices where both t1 and the slower TRPL decay (t2) are analyzed. The study shows that changes in performance expected from small changes in device processing may correlate better with t2. Numerical modeling further suggests that, for devices that are expected to have similar drift field in the depletion region, effects of changes in bulk MCL and interface recombination should be more pronounced in t2. Although this technique may provide future guidance to improving CdS/CdTe device performance, it is often difficult to extract statistically precise values for t2, and therefore t2 data may demonstrate significant scatter when correlated with performance parameters.

Gessert, T. A.; Dhere, R. G.; Duenow, J. N.; Kuciauskas, D.; Kanevce, A.; Bergeson, J. D.

2011-07-01T23:59:59.000Z

292

Lifetime Prediction for Degradation of Solar Mirrors using Step-Stress Accelerated Testing (Presentation)  

DOE Green Energy (OSTI)

This research is to illustrate the use of statistical inference techniques in order to quantify the uncertainty surrounding reliability estimates in a step-stress accelerated degradation testing (SSADT) scenario. SSADT can be used when a researcher is faced with a resource-constrained environment, e.g., limits on chamber time or on the number of units to test. We apply the SSADT methodology to a degradation experiment involving concentrated solar power (CSP) mirrors and compare the results to a more traditional multiple accelerated testing paradigm. Specifically, our work includes: (1) designing a durability testing plan for solar mirrors (3M's new improved silvered acrylic "Solar Reflector Film (SFM) 1100") through the ultra-accelerated weathering system (UAWS), (2) defining degradation paths of optical performance based on the SSADT model which is accelerated by high UV-radiant exposure, and (3) developing service lifetime prediction models for solar mirrors using advanced statistical inference. We use the method of least squares to estimate the model parameters and this serves as the basis for the statistical inference in SSADT. Several quantities of interest can be estimated from this procedure, e.g., mean-time-to-failure (MTTF) and warranty time. The methods allow for the estimation of quantities that may be of interest to the domain scientists.

Lee, J.; Elmore, R.; Kennedy, C.; Gray, M.; Jones, W.

2011-09-01T23:59:59.000Z

293

SU?E?I?47: Comparison of Risks for Two Medical Imaging Procedures  

Science Conference Proceedings (OSTI)

Purpose:Radiologists may need to decide which type of image procedure is most appropriate for a particular patient. One factor relevant in making this decision is the relative risk of secondary cancers due to each relevant procedure. Differences in the risk posed by each method are not just due to the total radiationdose imparted by each procedure

K Roy Choudhury; R Tian; X Li; E Samei

2012-01-01T23:59:59.000Z

294

ICT Supply Chain Risk Management  

Science Conference Proceedings (OSTI)

... ICT Supply Chain Risk Management Manager's Forum ... ICT Supply Chain Risk Management National Institute of Standards and Technology Page 6. ...

2013-06-04T23:59:59.000Z

295

Sociocultural definitions of risk  

SciTech Connect

Public constituencies frequently are criticized by technical experts as being irrational in response to low-probability risks. This presentation argued that most people are concerned with a variety of risk attributes other than probability and that is rather irrational to exclude these from the definition and analysis of technological risk. Risk communication, which is at the heart of the right-to-know concept, is described as the creation of shared meaning rather than the mere transmission of information. A case study of utilities, public utility commissions, and public interest groups illustrates how the diversity of institutional cultures in modern society leads to problems for the creation of shared meanings in establishing trust, distributing liability, and obtaining consent to risk. This holistic approach to risk analysis is most appropriate under conditions of high uncertainty and/or decision stakes. 1 fig., 5 tabs.

Rayner, S.

1990-10-01T23:59:59.000Z

296

DUF6 Environmental Risks  

NLE Websites -- All DOE Office Websites (Extended Search)

Risks A discussion of the potential environmental impacts associated with depleted uranium handling or processing facilities. Impacts Considered in the PEIS Depleted uranium...

297

Risk Management Tool Attributes:  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

of cost - input cost distribution; expert input on distribution selection g. time-phase input h. scenarios 2. Outputs a. Distributions b. Graphics c. Key risks (tornado) d....

298

Blackbody radiation shift, multipole polarizabilities, oscillator strengths, lifetimes, hyperfine constants, and excitation energies in Ca+  

E-Print Network (OSTI)

A systematic study of Ca+ atomic properties is carried out using high-precision relativistic all-order method where all single, double, and partial triple excitations of the Dirac-Fock wave functions are included to all orders of perturbation theory. Reduced matrix elements, oscillator strengths, transition rates, and lifetimes are determined for the levels up to n = 7. Recommended values and estimates of their uncertainties are provided for a large number of electric-dipole transitions. Electric-dipole scalar polarizabilities for the 5s, 6s, 7s, 8s, 4p, 5p, 3d, and 4d states and tensor polarizabilities for the 4p, 5p, 3d, and 4d states in Ca+ are calculated. Methods are developed to accurately treat the contributions from highly-excited states, resulting in significant (factor of 3) improvement in accuracy of the 3d_{5/2} static polarizability value, 31.8(3) a.u., in comparison with the previous calculation [Arora et al., Phys. Rev. A 76, 064501 (2007)]. The blackbody radiation (BBR) shift of the 4s - 3d_{5/2} clock transition in Ca+ is calculated to be 0.381(4) Hz at room temperature, T=300K. Electric-quadrupole 4s -nd and electric-octupole 4s -nf matrix elements are calculated to obtain the ground state multipole E2 and E3 static polarizabilities. The hyperfine constants A are determined for the low-lying levels up to n = 7. The quadratic Stark effect on hyperfine structure levels of 43Ca+ ground state is investigated. These calculations provide recommended values critically evaluated for their accuracy for a number of Ca+ atomic properties for use in planning and analysis of various experiments as well as theoretical modeling.

M. S. Safronova; U. I. Safronova

2010-11-27T23:59:59.000Z

299

Variation in Use of Androgen Suppression With External-Beam Radiotherapy for Nonmetastatic Prostate Cancer  

SciTech Connect

Purpose: To describe practice patterns associated with androgen suppression (AS) stratified by disease risk group in patients undergoing external-beam radiotherapy (EBRT) for localized prostate cancer. Methods and Materials: We identified 2,184 low-risk, 2,339 intermediate-risk, and 2,897 high-risk patients undergoing EBRT for nonmetastatic prostate cancer diagnosed between January 1, 2004, and December 31, 2005, in the linked Surveillance, Epidemiology, and End Results-Medicare database. We examined the association of patient, clinical, and demographic characteristics with AS use by multivariate logistic regression. Results: The proportions of patients receiving AS for low-risk, intermediate-risk, and high-risk prostate cancer were 32.2%, 56.3%, and 81.5%, respectively. AS use among men in the low-risk disease category varied widely, ranging from 13.6% in Detroit to 47.8% in Kentucky. We observed a significant decline in AS use between 2004 and 2005 within all three disease risk categories. Men aged {>=}75 years or with elevated comorbidity levels were more likely to receive AS. Conclusion: Our results identified apparent overuse and underuse of AS among men within the low-risk and high-risk disease categories, respectively. These results highlight the need for clinician and patient education regarding the appropriate use of AS. Practice patterns among intermediate-risk patients reflect the clinical heterogeneity of this population and underscore the need for better evidence to guide the treatment of these patients.

Swisher-McClure, Samuel, E-mail: Swisher-Mcclure@uphs.upenn.edu [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Pollack, Craig E. [Division of General Internal Medicine, Johns Hopkins University School of Medicine and Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (United States); Christodouleas, John P. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (United States); Guzzo, Thomas J. [Department of Surgery, Division of Urology, University of Pennsylvania, Philadelphia, PA (United States); Haas, Naomi B. [Department of Medicine, Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA (United States); Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (United States); Vapiwala, Neha [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (United States); Bekelman, Justin E. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (United States); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA (United States)

2012-05-01T23:59:59.000Z

300

Application of the U.S. high cycle fatigue data base to wind turbine blade lifetime predictions  

DOE Green Energy (OSTI)

This paper demonstrates a methodology for predicting the service lifetime of wind turbine blades using the high-cycle fatigue data base for typical U.S. blade materials developed by Mandell, et al. (1995). The first step in the analysis is to normalize the data base (composed primarily of data obtained from specialized, relatively small coupons) with fatigue data from typical industrial laminates to obtain a Goodman Diagram that is suitable for analyzing wind turbine blades. The LIFE2 fatigue analysis code for wind turbines is then used for the fatigue analysis of a typical turbine blade with a known load spectrum. In the analysis, a linear damage model, Miner`s Rule, is used to demonstrate the prediction of the service lifetime for a typical wind turbine blade under assumed operating strain ranges and stress concentration factors. In contrast to typical European data, the asymmetry in this data base predicts failures under typical loads to be compressive.

Sutherland, H.J. [Sandia National Labs., Albuquerque, NM (United States); Mandell, J.F. [Montana State Univ., Bozeman, MT (United States)

1995-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Zinc Deficiency Linked to Increased Risk of Less-Common Form of Esophageal  

NLE Websites -- All DOE Office Websites (Extended Search)

National Cancer Institute National Cancer Institute Journal of the NCI X-ray Microscopy Group Zinc Deficiency Linked to Increased Risk of Less-Common Form of Esophageal Cancer Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, using x-ray fluorescence spectroscopy at X-ray Operations and Research beamline 2-BM at the U.S. Department of Energy's Advanced Photon Source have found that zinc deficiency in humans is associated with an increased risk of developing esophageal squamous cell carcinoma, an often-fatal form of esophageal cancer that has about 7,000 cases a year. NCI researchers used a novel approach to measure the concentration of zinc and other elements directly in the esophageal tissue. Their results, appearing in the February 15, 2005, Journal of the National

302

Long lifetime, low intensity light source for use in nighttime viewing of equipment maps and other writings  

DOE Patents (OSTI)

A long-lifetime light source is discussed with sufficiently low intensity to be used for reading a map or other writing at nightime, while not obscuring the user's normal night vision. This light source includes a diode electrically connected in series with a small power source and a lens properly positioned to focus at least a portion of the light produced by the diode.

Frank, A.M.; Edwards, W.R.

1982-03-23T23:59:59.000Z

303

Long lifetime, low intensity light source for use in nighttime viewing of equipment maps and other writings  

DOE Patents (OSTI)

A long-lifetime light source with sufficiently low intensity to be used for reading a map or other writing at nighttime, while not obscuring the user's normal night vision. This light source includes a diode electrically connected in series with a small power source and a lens properly positioned to focus at least a portion of the light produced by the diode.

Frank, Alan M. (Livermore, CA); Edwards, William R. (Modesto, CA)

1983-01-01T23:59:59.000Z

304

Long lifetime, low intensity light source for use in nighttime viewing of equipment maps and other writings  

DOE Patents (OSTI)

A long-lifetime light source with sufficiently low intensity to be used for reading a map or other writing at nighttime, while not obscuring the user's normal night vision is disclosed. This light source includes a diode electrically connected in series with a small power source and a lens properly positioned to focus at least a portion of the light produced by the diode. 1 fig.

Frank, A.M.; Edwards, W.R.

1983-10-11T23:59:59.000Z

305

Performance of ad hoc networks with two-hop relay routing and limited packet lifetime (extended version)  

Science Conference Proceedings (OSTI)

We consider a mobile ad hoc network consisting of three types of nodes (source, destination and relay nodes) and using the two-hop relay routing. This type of routing takes advantage of the mobility and the storage capacity of the nodes, called the relay ... Keywords: Delay tolerant network, Limited packet lifetime, Mobile ad hoc network, Mobility model, Performance analysis, Two-hop relay protocol

Ahmad Al Hanbali; Philippe Nain; Eitan Altman

2008-06-01T23:59:59.000Z

306

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

Graphic Results Graphic Results Baseline Risk Assessment Results Screening Risk Assessment Results Other Risk Assessment Results Graphic Results K-25 Groundwater Residential Landuse Bedrock Wells - Total Hazard (range: 1-30) Bedrock Wells - Total Hazard (range: 0.1 - 1) Bedrock Wells - Total Risk Bedrock Wells - Arsenic Risk Bedrock Wells - Dichloroethene, 1,1- Risk Bedrock Wells - Trichloroethene Risk Unconsolidated Wells - Total Hazard (range: 1-150) Unconsolidated Wells - Total Hazard (range: 0.1 - 1) Unconsolidated Wells - Total Risk (range:10-4 - 1) Unconsolidated Wells - Total Risk (range:10-6 - 10-4) Unconsolidated Wells - Arsenic Risk Unconsolidated Wells - Trichloroethene Risk ORNL WAG 2 Residential Landuse Sediment - Total Risk Sediment - Cesium 137 Risk Sediment - Cobalt 60 Risk

307

171Yb+ System Stability, 5D3/2 Hyperfine State Detection Efficiency and F=2 Lifetime  

E-Print Network (OSTI)

A data acquisition system is described that is designed to stabilize cooling and probe rates to maximize detection sensitivity and minimize possible systematic errors due to correlations between drifting experimental conditions and varying drive parameters. Experimental parameters that affect the Yb171 5D3/2 hyperfine state preparation and detection efficiency are characterized and optimized. A set of wait times for optimal sampling of the D3/2(F=2) lifetime is chosen and used to measure that lifetime with high statistical sensitivity. A systematic variation in this lifetime seems to be apparent. The source of the variation was not identified, but ion number and cooling rate appear to be ruled out. A net determination is made of tau=61.8ms+-(0.6)_stat+-(6.4)_sys which is significantly longer than other measurements of the same quantity. An alternate shelving scheme is proposed that would provide S-D state discrimination for Yb even isotopes as well as improved sensitivity for D state hyperfine discrimination ...

Schacht, M

2013-01-01T23:59:59.000Z

308

Risk and risk management in software projects: A reassessment  

Science Conference Proceedings (OSTI)

Controlling risk in software projects is considered to be a major contributor to project success. This paper reconsiders the status of risk and risk management in the literature and practice. The analysis is supported by a study of risk practices in ... Keywords: Project management, Risk management, Software projects, Threat management

Paul L. Bannerman

2008-12-01T23:59:59.000Z

309

Risk management for IT and software projects  

Science Conference Proceedings (OSTI)

Risk management can be defined as a systematic process for identifying, analyzing and controlling risks in projects or organizations. Definitions and illustrations of risks are given; in particular, a list of ten risk factors which occur most frequently ... Keywords: Riskit, analysis of risks, control of risks, identification of risks, monitoring of risks, project risks, quality management, risk definition, risk management, risk management process, risk scenario

E. Wallmüller

2002-01-01T23:59:59.000Z

310

Spontaneous Fission Modes and Lifetimes of Superheavy Elements in the Nuclear Density Functional Theory  

Science Conference Proceedings (OSTI)

Background: The reactions with the neutron-rich 48Ca beam and actinide targets resulted in the detection of new superheavy (SH) nuclides with Z=104 118. The unambiguous identification of the new isotopes, however, still poses a problem because their -decay chains terminate by spontaneous fission (SF) before reaching the known region of the nuclear chart. The understanding of the competition between -decay and SF channels in SH nuclei is, therefore, of crucial importance for our ability to map the SH region and to assess its extent. Purpose: We perform self-consistent calculations of the competing decay modes of even-even SH isotopes with 108 Z 126 and 148 N 188. Methods: We use the state-of-the-art computational framework based on self-consistent symmetry-unrestricted nuclear density functional theory capable of describing the competition between nuclear attraction and electrostatic repulsion. We apply the SkM* Skyrme energy density functional. The collective mass tensor of the fissioning superfluid nucleus is computed by means of the cranking approximation to the adiabatic time-dependent Hartree-Fock-Bogoliubov (HFB) approach. This paper constitutes a systematic self-consistent study of spontaneous fission in the SH region, carried out at a full HFB level, that simultaneously takes into account both triaxiality and reflection asymmetry. Results: Breaking axial symmetry and parity turns out to be crucial for a realistic estimate of collective action; it results in lowering SF lifetimes by more than 7 orders of magnitude in some cases. We predict two competing SF modes: reflection symmetric modes and reflection asymmetric modes. Conclusions: The shortest-lived SH isotopes decay by SF; they are expected to lie in a narrow corridor formed by 280Hs, 284Fl, and 118284Uuo that separates the regions of SH nuclei synthesized in cold-fusion and hot-fusion reactions. The region of long-lived SH nuclei is expected to be centered on 294Ds with a total half-life of 1.5 days. Our survey provides a solid benchmark for the future improvements of self-consistent SF calculations in the region of SH nuclei.

Staszczak, A, [UTK/ORNL/Inst. Physics, Maria Curie-Sklodowska University, Poland; Baran, A. [UTK/ORNL/Inst. Physics, Maria Curie-Sklodowska University, Poland; Nazarewicz, Witold [UTK/ORNL/University of Warsaw

2013-01-01T23:59:59.000Z

311

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

Risk Assessment Documents Risk Assessment Documents Y-12 RA Graphic Results Y-12 Baseline Risk Assessment Results Y-12 Screening Risk Assessment Results Bullet Graphic Risk Results Arrow Bear Creek Valley Maps Residential Landuse Groundwater - Total Hazard (range: 1 - 900) Groundwater - Total Hazard (range: 0.1 - 1) Groundwater - Total Risk (range: 10-4 - 1) Groundwater - Total Risk (range: 10-5 - 10-4) Groundwater - Total Risk (range: 10-6 - 10-5) Groundwater - Dichloroethane, 1,1- Hazard Groundwater - Dichloroethene, 1,1- Hazard Groundwater - Dichloroethene, 1,1- Risk Groundwater - Dichloroethane, 1,2- Risk Groundwater - Dichloroethene, 1,2- Hazard Groundwater - Nitrate Hazard Groundwater - Radium Risk Groundwater - Technetium-99 Risk Groundwater - Tetrachloroethene Hazard Groundwater - Tetrachloroethene Risk

312

RISK-INFORMED SAFETY MARGIN CHARACTERIZATION  

Science Conference Proceedings (OSTI)

The concept of safety margins has served as a fundamental principle in the design and operation of commercial nuclear power plants (NPPs). Defined as the minimum distance between a system’s “loading” and its “capacity”, plant design and operation is predicated on ensuring an adequate safety margin for safety-significant parameters (e.g., fuel cladding temperature, containment pressure, etc.) is provided over the spectrum of anticipated plant operating, transient and accident conditions. To meet the anticipated challenges associated with extending the operational lifetimes of the current fleet of operating NPPs, the United States Department of Energy (USDOE), the Idaho National Laboratory (INL) and the Electric Power Research Institute (EPRI) have developed a collaboration to conduct coordinated research to identify and address the technological challenges and opportunities that likely would affect the safe and economic operation of the existing NPP fleet over the postulated long-term time horizons. In this paper we describe a framework for developing and implementing a Risk-Informed Safety Margin Characterization (RISMC) approach to evaluate and manage changes in plant safety margins over long time horizons.

Nam Dinh; Ronaldo Szilard

2009-07-01T23:59:59.000Z

313

Cancer in Australia  

E-Print Network (OSTI)

statistics and information agency. The Institute’s mission is better health and wellbeing for Australians through better health and welfare statistics and information. The Australasian Association of Cancer Registries (AACR) is a collaborative body representing state and territory cancer registries in Australia and New Zealand. Most are members of the International Association of Cancer Registries. The AACR was formed in November 1982 to provide a formal mechanism for promoting uniformity of collection, classification and collation of cancer data. The objectives of the AACR are to: • Achieve national agreement on cancer-specific data definitions and coding and to encourage compliance with such agreements. As far as possible, data definitions and coding should be consistent with existing International Association of Cancer Registries (IACR) protocols and conventions. Facilitate the production of Australian, state and territory and national statistical publications on cancer that are comparable with each other and with international statistical publications. Improve the operational efficiency, and data completeness and quality, of the state and territory and New Zealand cancer registries through collaborative sharing of information. Contribute to national cancer control development in Australia and New Zealand through the regular and timely publication of local and national cancer statistics and the provision of data for cancer control research and health promotion. Contribute national data to international publications of the IACR. Contribute to international cancer coding and statistical analysis developments via members ’ involvement with IACR. Facilitate national epidemiological research projects on cancer (given appropriate local and AIHW ethics committee approvals).CANCER SERIES Number 28

unknown authors

2004-01-01T23:59:59.000Z

314

Radiation Risk from Chronic Low Dose-Rate Radiation Exposures: The Role of Life-Time Animal Studies - Workshop October 2005  

SciTech Connect

As a part of Radiation research conference, a workshop was held on life-long exposure studies conducted in the course of irradiation experiements done at Argonne National Laboratory between 1952-1992. A recent review article documents many of the issues discussed at that workshop.

Gayle Woloschak

2009-12-16T23:59:59.000Z

315

Supporting clinical processes with semantic web technologies: a case in breast cancer treatment  

Science Conference Proceedings (OSTI)

Breast cancer surgery is carried out almost entirely manually and there is an obvious risk of human error due to temporary or occasional lack of staff experience (substitutions, sick leaves and other reasons). Another aspect is that the successful ... Keywords: OWL, SOA, automated decision making, breast cancer, cancer treatment, e-healthcare, electronic healthcare, electronic healthcare records, electronic medical records, monitoring, ontologies, ontology web language, patient safety, prognostic factors, semantic web, service-oriented architecture

Ainhoa Serna Nocedal; Jon Kepa Gerrikagoitia; Iker Huerga

2010-09-01T23:59:59.000Z

316

Risk And Risk Management In Geothermal Exploration And Development...  

Open Energy Info (EERE)

Up Search Page Edit with form History Facebook icon Twitter icon Risk And Risk Management In Geothermal Exploration And Development Jump to: navigation, search GEOTHERMAL...

317

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

Debra Stewart at (865)482-2657 or dthomas3@utk.edu. Risk assessments conducted for the DOE-ORO should implement Guidance for Conducting Risk Assessments and Related Risk...

318

Risk in the Weapons Stockpile  

Science Conference Proceedings (OSTI)

When it comes to the nuclear weapons stockpile, risk must be as low as possible. Design and care to keep the stockpile healthy involves all aspects of risk management. Design diversity is a method that helps to mitigate risk.

Noone, Bailey C [Los Alamos National Laboratory

2012-08-14T23:59:59.000Z

319

High Risk Plan  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Risk Plan Risk Plan John Bashista Melissa Rider Jeff Davis Timeline to date * OMB memo on Improving Government Acquisition issued July 29, 2009 - Review existing contracts and acquisition practices to save 7% of baseline contract spending (3.5% in FY 2010 and 3.5% in FY 2011) - Reduce high risk contracts by 10% the share of dollars obligated in FY2010 - Final plan was due and submitted on November 2, 2009 - OMB reviewed and requested revision Dec 23, 2009 - Revision submitted April 21, 2010 M&Os are an Issue * With respect to reductions in high risk contracting strategies, the M&O contracts was also a challenge since the opportunity to further influence competition and contract type was highly constrained. The Department had already competed approximately 85 percent of its M&O

320

Risk Management RM  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Risk Management Review Module Risk Management Review Module March 2010 CD-0 O 0 OFFICE OF C CD-1 F ENVIRO Standard R Risk M Rev Critical Decis CD-2 M ONMENTAL Review Plan Managem view Module sion (CD) Ap CD March 2010 L MANAGE (SRP) ment e pplicability D-3 EMENT CD-4 Post Ope eration Standard Review Plan, 2 nd Edition, March 2010 i FOREWORD The Standard Review Plan (SRP) 1 provides a consistent, predictable corporate review framework to ensure that issues and risks that could challenge the success of Office of Environmental Management (EM) projects are identified early and addressed proactively. The internal EM project review process encompasses key milestones established by DOE O 413.3A, Change 1, Program and Project Management for the Acquisition of Capital Assets, DOE-STD-1189-2008, Integration of Safety into the Design Process, and EM's internal

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Risks to the public  

Science Conference Proceedings (OSTI)

Edited by Peter G. Neumann (Risks Forum Moderator and Chairman of the ACM Committee on Computers and Public Policy), plus personal contributions by others, as indicated. Opinions expressed are individual rather than organizational, and all of the usual ...

Peter G. Neumann

2009-02-01T23:59:59.000Z

322

Risks to the public  

Science Conference Proceedings (OSTI)

Edited by Peter G. Neumann (Risks Forum Moderator and Chairman of the ACM Committee on Computers and Public Policy), plus personal contributions by others, as indicated. Opinions expressed are individual rather than organizational, and all of the usual ...

Peter G. Neumann

2006-11-01T23:59:59.000Z

323

Risks to the public  

Science Conference Proceedings (OSTI)

Edited by Peter G. Neumann (Risks Forum Moderator and Chairman of the ACM Committee on Computers and Public Policy), plus personal contributions by others, as indicated. Opinions expressed are individual rather than organizational, and all of the usual ...

Peter G. Neumann

2005-07-01T23:59:59.000Z

324

Risks to the public  

Science Conference Proceedings (OSTI)

Edited by Peter G. Neumann (Risks Forum Moderator and Chairman of the ACM Committee on Computers and Public Policy), plus personal contributions by others, as indicated. Opinions expressed are individual rather than organizational, and all of the usual ...

Peter G. Neumann

2009-05-01T23:59:59.000Z

325

Risks to the public  

Science Conference Proceedings (OSTI)

Edited by Peter G. Neumann (Risks Forum Moderator and Chairman of the ACM Committee on Computers and Public Policy), plus personal contributions by others, as indicated. Opinions expressed are individual rather than organizational, and all of the usual ...

Peter G. Neumann

2008-10-01T23:59:59.000Z

326

Risks to the public  

Science Conference Proceedings (OSTI)

Edited by Peter G. Neumann (Risks Forum Moderator and Chairman of the ACM Committee on Computers and Public Policy), plus personal contributions by others, as indicated. Opinions expressed are individual rather than organizational, and all of the usual ...

Peter G. Neumann

2005-11-01T23:59:59.000Z

327

Risks to the public  

Science Conference Proceedings (OSTI)

Edited by Peter G. Neumann (Risks Forum Moderator and Chairman of the ACM Committee on Computers and Public Policy), plus personal contributions by others, as indicated. Opinions expressed are individual rather than organizational, and all of the usual ...

Peter G. Neumann

2005-05-01T23:59:59.000Z

328

Cancer Due to Prolonged Inflammation  

E-Print Network (OSTI)

Development. Molecular Cancer Research 4.221 (2006): 5-261.direction of future cancer research is to better understand

Lingampalli, Nithya

2013-01-01T23:59:59.000Z

329

Residential radon and lung cancer incidence in a Danish cohort  

SciTech Connect

High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993-1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed. Median estimated radon was 35.8 Bq/m{sup 3}. The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69-1.56) in association with a 100 Bq/m{sup 3} higher radon concentration and 1.67 (95% CI: 0.69-4.04) among non-smokers. We found no evidence of effect modification. We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

Braeuner, Elvira V., E-mail: ole@cancer.dk [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Danish Building Research Institute, Aalborg University (Denmark); Andersen, Claus E. [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark)] [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark); Sorensen, Mette [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Jovanovic Andersen, Zorana [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark) [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Center for Epidemiology Screening, Department of Public Health, University of Copenhagen (Denmark); Gravesen, Peter [Geological Survey of Denmark and Greenland, Copenhagen (Denmark)] [Geological Survey of Denmark and Greenland, Copenhagen (Denmark); Ulbak, Kaare [National Institute of Radiation Protection, Herlev (Denmark)] [National Institute of Radiation Protection, Herlev (Denmark); Hertel, Ole [Department of Environmental Science, Aarhus University, Aarhus (Denmark)] [Department of Environmental Science, Aarhus University, Aarhus (Denmark); Pedersen, Camilla [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Overvad, Kim [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark)] [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark); Tjonneland, Anne; Raaschou-Nielsen, Ole [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)

2012-10-15T23:59:59.000Z

330

Risk Mitigation Strategies  

Science Conference Proceedings (OSTI)

This technical update builds upon the development of attack/failure and cyber-physical attack scenarios focused on combined cyber-physical attacks. These scenarios include threats and vulnerabilities that may be exploited by well-financed and motivated entities. It also leverages risk assessment processes developed to address combined cyber-physical attack scenarios. The framework in this update supports the further development of risk mitigation strategies focused on combined cyber-physical ...

2012-12-28T23:59:59.000Z

331

Transmission Price Risk Management  

Science Conference Proceedings (OSTI)

This report is concerned with the financial risks that arise from the uncertain price of transmission service in restructured or competitive electricity markets. These risks are most severe in markets with locational pricing (LMP), but they also exist in more traditionally organized electricity markets. This report has two main purposes. The first is to review the existing mathematical models of electricity price formation in spot and forward markets that may be helpful as the foundations for developing ...

2006-12-04T23:59:59.000Z

332

Lessons learned: Needs for improving human health risk assessment at USDOE Sites  

SciTech Connect

Realistic health risk assessments were performed in a pilot study of three U.S. Department of Energy (USDOE) sites. These assessments, covering a broad spectrum of data and methods, were used to identify needs for improving future health risk assessments at USDOE sites. Topics receiving specific recommendations for additional research include: choice of distributions for Monte Carlo simulation; estimation of risk reduction; analysis of the U.S. Department of Agriculture Database on food and nutrient intakes; investigations on effects of food processing on contaminant levels; background food and environmental concentrations of contaminants; method for handling exposures to groundwater plumes, methods for analyzing less than lifetime exposure to carcinogens; and improvement of bioaccumulation factors.

Hamilton, L.D.; Holtzman, S.; Meinhold, A.F.; Morris, S.C.; Rowe, M.D. [Brookhaven National Lab., Upton, NY (United States); Daniels, J.I.; Layton, D.W.; Anspaugh, L.R. [Lawrence Livermore National Lab., CA (United States)

1993-09-01T23:59:59.000Z

333

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

Guidance for Conducting Risk Assessments and Related Risk Activities for the DOE-ORO Environmental Management Program. BJCOR-271 Guidance for Treatment of Variability and...

334

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

risk assessment information used to evaluate and remediate legacy contamination from the Manhattan Project. The RAIS was designed to provide all risk assessment processes in a...

335

Risk Management Process Overview | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Cybersecurity Risk Management Process Risk Management Process Overview Risk Management Process Overview figure depicting three tier risk management process The cybersecurity...

336

US/UK second level panel discussions on the health and value of: Ageing and lifetime predictions (u)  

SciTech Connect

Many healthy physics, engineering, and materials exchanges are being accomplished in ageing and lifetime prediction that directly supports US and UK Stockpile Management Programs. Lifetime assessment studies of silicon foams under compression - Joint AWE/LANLlLLNL study of compression set in stress cushions completed. Provides phenomenological prediction out to 50 years. Polymer volatile out-gassing studies - New exchange on the out-gassing of Ethylene Vinyl Acetate (EVA) using isotopic {sup 13}C labeling studies to interrogate mechanistic processes. Infra-red (IR) gas cell analytical capabilities developed by AWE will be used to monitor polymer out-gassing profiles. Pu Strength ageing Experiments and Constitutive Modeling - In recently compared modeling strategies for ageing effects on Pu yield strength at high strain rates, a US/UK consensus was reached on the general principle that the ageing effect is additive and not multiplicative. The fundamental mechanisms for age-strengthening in Pu remains unknown. Pu Surface and Interface Reactions - (1) US/UK secondment resulted in developing a metal-metal oxide model for radiation damaged studies consistent with a Modified Embedded Atom Method (MEAM) potential; and (2) Joint US/UK collaboration to study the role of impurities in hydride initiation. Detonator Ageing (wide range of activities) - (1) Long-term ageing study with field trials at Pantex incorporating materials from LANL, LLNL, SNL and AWE; (2) Characterization of PETN growth to detonation process; (3) Detonator performance modeling; and (4) Performance fault tree analysis. Benefits are a unified approach to lifetime prediction that Includes: materials characterization and the development of ageing models through improved understanding of the relationship between materials properties, ageing properties and detonator performance.

Castro, Richard G [Los Alamos National Laboratory

2011-01-18T23:59:59.000Z

337

The Post-Shock Chemical Lifetimes of Outflow Tracers and a Possible New Mechanism to Produce Water Ice Mantles  

E-Print Network (OSTI)

We have used a coupled time-dependent chemical and dynamical model to investigate the lifetime of the chemical legacy left in the wake of C-type shocks. We concentrate this study on the chemistry of H2O and O2, two molecules which are predicted to have abundances that are significantly affected in shock-heated gas. Two models are presented: (1) a three-stage model of pre-shock, shocked, and post-shock gas; and (2) a Monte-Carlo cloud simulation where we explore the effects of stochastic shock activity on molecular gas over a cloud lifetime. In agreement with previous studies, we find that shock velocities in excess of 10 km s^-1 are required to convert all of the oxygen not locked in CO into H2O before the gas has an opportunity to cool. For pure gas-phase models the lifetime of the high water abundances, or ``H2O legacy'', in the post-shock gas is 4 - 7 x 10^5 years. Through the Monte Carlo cloud simulation we demonstrate that the time-average abundance of H2O is a sensitive function of the frequency of shocks. Thus we predict that the abundance of H2O and other known outflow tracers can be used to trace the history of shock activity in molecular gas. For gas-grain models we find that the abundance of water-ice on grain surfaces can be quite large and is comparable to that observed in molecular clouds. This offers a possible alternative method to create water mantles without resorting to grain surface chemistry: gas heating and chemical modification due to a C-type shock and subsequent depletion of the gas-phase species onto grain mantles.

Edwin A. Bergin; Gary J. Melnick; David A. Neufeld

1998-03-30T23:59:59.000Z

338

Shark cartilage and cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

speculation in the past that there may be some factor in shark's cartilage that prevents cancer, recent research by the National Cancer Institute could not confirm this, and there...

339

Soy and breast cancer  

Science Conference Proceedings (OSTI)

Are soy foods safe for breast cancer patients? Soy is a rich source of isoflavones (primarily genistein, daidzein, and glycitein). The standard oral therapy undertaken after initial treatment (known as “adjuvant therapy”) for estrogen-sensitive cancers is

340

New Mass and Lifetime Measurements of $^{152}$Sm Projectile Fragments with Time-Resolved Schottky Mass Spectrometry  

E-Print Network (OSTI)

The FRS-ESR facilities at GSI provide unique conditions for precision measurements with stored exotic nuclei over a large range in the chart of nuclides. In the present experiment the exotic nuclei were produced via fragmentation of $^{152}$Sm projectiles in a thick beryllium target at 500-600 MeV/u, separated in-flight with the fragment separator FRS, and injected into the storage-cooler ring ESR. Mass and lifetime measurements have been performed with bare and few-electron ions. The experiment and first results will be presented in this contribution.

Litvinov, Y A; Geissel, H; Weick, H; Beckert, Karl; Beller, Peter; Boutin, D; Brandau, C; Chen, L; Klepper, O; Knöbel, R; Kozhuharov, C; Kurcewicz, J; Litvinov, S A; Mazzocco, M; Münzenberg, G; Nociforo, C; Nolden, F; Plass, W; Scheidenberger, C; Steck, Markus; Sun, B; Winkler, M; Litvinov, Yu.A.

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Value Proposition for High Lifetime (p-type) and Thin Silicon Materials in Solar PV Applications: Preprint  

DOE Green Energy (OSTI)

Most silicon PV road maps forecast a continued reduction in wafer thickness, despite rapid declines in the primary incentive for doing so -- polysilicon feedstock price. Another common feature of most silicon-technology forecasts is the quest for ever-higher device performance at the lowest possible costs. The authors present data from device-performance and manufacturing- and system-installation cost models to quantitatively establish the incentives for manufacturers to pursue advanced (thin) wafer and (high efficiency) cell technologies, in an age of reduced feedstock prices. This analysis exhaustively considers the value proposition for high lifetime (p-type) silicon materials across the entire c-Si PV supply chain.

Goodrich, A.; Woodhouse, M.; Hacke, P.

2012-06-01T23:59:59.000Z

342

Radiation-Induced Cancers From Modern Radiotherapy Techniques: Intensity-Modulated Radiotherapy Versus Proton Therapy  

Science Conference Proceedings (OSTI)

Purpose: To assess and compare secondary cancer risk resulting from intensity-modulated radiotherapy (IMRT) and proton therapy in patients with prostate and head-and-neck cancer. Methods and Materials: Intensity-modulated radiotherapy and proton therapy in the scattering mode were planned for 5 prostate caner patients and 5 head-and-neck cancer patients. The secondary doses during irradiation were measured using ion chamber and CR-39 detectors for IMRT and proton therapy, respectively. Organ-specific radiation-induced cancer risk was estimated by applying organ equivalent dose to dose distributions. Results: The average secondary doses of proton therapy for prostate cancer patients, measured 20-60cm from the isocenter, ranged from 0.4 mSv/Gy to 0.1 mSv/Gy. The average secondary doses of IMRT for prostate patients, however, ranged between 3 mSv/Gy and 1 mSv/Gy, approximately one order of magnitude higher than for proton therapy. Although the average secondary doses of IMRT were higher than those of proton therapy for head-and-neck cancers, these differences were not significant. Organ equivalent dose calculations showed that, for prostate cancer patients, the risk of secondary cancers in out-of-field organs, such as the stomach, lungs, and thyroid, was at least 5 times higher for IMRT than for proton therapy, whereas the difference was lower for head-and-neck cancer patients. Conclusions: Comparisons of organ-specific organ equivalent dose showed that the estimated secondary cancer risk using scattering mode in proton therapy is either significantly lower than the cases in IMRT treatment or, at least, does not exceed the risk induced by conventional IMRT treatment.

Yoon, Myonggeun, E-mail: mxy131@ncc.re.k [Proton Therapy Center, National Cancer Center, Goyang (Korea, Republic of); Ahn, Sung Hwan; Kim, Jinsung; Shin, Dong Ho; Park, Sung Yong; Lee, Se Byeong; Shin, Kyung Hwan; Cho, Kwan Ho [Proton Therapy Center, National Cancer Center, Goyang (Korea, Republic of)

2010-08-01T23:59:59.000Z

343

From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory  

Science Conference Proceedings (OSTI)

In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

Martineau, Rebecca M [Los Alamos National Laboratory

2012-07-26T23:59:59.000Z

344

Reflections in Mutation Research Electric light causes cancer?  

E-Print Network (OSTI)

]. And on a population level, there is a strong international correlation between estimates of per capita fat consumption) wasted energy, (3) harm to animal and plant life, (4) and perhaps increases in some severe human maladies dismayed by the recent reports that dietary fat consumption was unrelated to risk of breast cancer in women

Oliver, Douglas L.

345

Charge Lifetime Study of K2CsSb Photocathode Inside a JLAB DC High Voltage Gun  

SciTech Connect

Two photocathodes are frequently considered for generating high average current electron beams and/or beams with high brightness for current and future accelerator applications: GaAs:Cs and K2CsSb. Each photocathode has advantages and disadvantages, and need to demonstrate performance at 'production' accelerator facilities. To this end a K2CsSb photocathode was manufactured at Brookhaven National Lab and delivered to Jefferson Lab within a compact vacuum apparatus at pressure {approx} 5 x 10{sup -11} Torr. This photocathode was installed inside a dc high voltage photogun biased at voltages up to 200 kV, and illuminated with laser light at 440 or 532 nm, to generate beams up to 20 mA. Photocathode charge lifetime measurements indicate that under some conditions this cathode has exceptionally high charge lifetime, without measurable QE decay, even from the center of the photocathode where operation using GaAs photocathodes is precluded due to ion bombardment. These studies also suggest a complex QE decay mechanism likely related to chemistry and localized heating via the laser beam.

Mammei, R.; Rao, T.; Suleiman, R.; Poelker, M.; Smedley, J.; McCarter, J.L.

2011-10-01T23:59:59.000Z

346

Distribution of lifetimes of kinetochore-microtubule attachments:interplay of energy landscape, molecular motors and microtubule (de-)polymerization  

E-Print Network (OSTI)

Before a cell divides into two daughter cells, the chromosomes are replicated resulting in two sister chromosomes embracing each other. Each sister chromosome is bound to a separate proteinous structure, called kinetochore (kt), that captures the tip of a filamentous protein, called microtubule (MT). Two oppositely oriented MTs pull the two kts attached to two sister chromosomes thereby pulling the two sisters away from each other. Here we theoretically study an even simpler system, namely an isolated kt coupled to a single MT; this system mimics an {\\it in-vitro} experiment where a single kt-MT attachment is reconstituted using purified extracts from budding yeast. Our models not only account for the experimentally observed "catch-bond-like" behavior of the kt-MT coupling, but also make new predictions on the probability distribution of the lifetimes of the attachments. In principle, our new predictions can be tested by analyzing the data collected in the {\\it in-vitro} experiments provided the experiment is repeated sufficiently large number of times. Our theory provides a deep insight into the effects of (a) size, (b) energetics, and (c) stochastic kinetics of the kt-MT coupling on the distribution of the lifetimes of these attachments.

Ajeet K. Sharma; Blerta Shtylla; Debashish Chowdhury

2013-10-06T23:59:59.000Z

347

Mercury Risk Assessment  

NLE Websites -- All DOE Office Websites (Extended Search)

ASSESSING THE MERCURY HEALTH RISKS ASSOCIATED ASSESSING THE MERCURY HEALTH RISKS ASSOCIATED WITH COAL-FIRED POWER PLANTS: IMPACTS OF LOCAL DEPOSITIONS *T.M. Sullivan 1 , F.D. Lipfert 2 , S.M. Morris 2 , and S. Renninger 3 1 Building 830, Brookhaven National Laboratory, Upton, NY 11973 2 Private Consultants 3 Department of Energy, National Energy Technology Laboratory, Morgantown, WV ABSTRACT The U.S. Environmental Protection Agency has announced plans to regulate emissions of mercury to the atmosphere from coal-fired power plants. However, there is still debate over whether the limits should be placed on a nationwide or a plant-specific basis. Before a nationwide limit is selected, it must be demonstrated that local deposition of mercury from coal-fired power plants does not impose an excessive local health risk. The principal health

348

Defining the Critical Hurdles in Cancer Immunotherapy  

E-Print Network (OSTI)

Australia. Ovarian Cancer Research Center, University ofal: New models for cancer research: human cancer stem cellAmerican Association for Cancer Research 2010, 16:2861-71.

2011-01-01T23:59:59.000Z

349

Equipment Risk and Performance Assessment  

Science Conference Proceedings (OSTI)

Risk assessment and management are key elements in a well developed asset management implementation. Consequently an increasing number of utility managers are devoting resources to the task of improving their capabilities for risk-based decision making. Equipment risk models are essential elements in a risk assessment process. However, most proposed power delivery equipment risk models require for their successful application some probabilistic representation describing the chances of equipment ...

2012-12-14T23:59:59.000Z

350

Equipment Risk and Performance Assessment  

Science Conference Proceedings (OSTI)

Risk assessment and management are key elements in a well-developed asset management implementation. Consequently, an increasing number of utility managers are devoting resources to the task of improving their capabilities for risk-based decision making. Equipment risk models are essential elements in the risk assessment process. However, for their application, most proposed power delivery equipment risk models require some probabilistic representation describing the chances of equipment failure. This re...

2011-12-21T23:59:59.000Z

351

NGNP Risk Management Database: A Model for Managing Risk  

Science Conference Proceedings (OSTI)

The Next Generation Nuclear Plant (NGNP) Risk Management System (RMS) is a database used to maintain the project risk register. The RMS also maps risk reduction activities to specific identified risks. Further functionality of the RMS includes mapping reactor suppliers Design Data Needs (DDNs) to risk reduction tasks and mapping Phenomena Identification Ranking Table (PIRTs) to associated risks. This document outlines the basic instructions on how to use the RMS. This document constitutes Revision 1 of the NGNP Risk Management Database: A Model for Managing Risk. It incorporates the latest enhancements to the RMS. The enhancements include six new custom views of risk data - Impact/Consequence, Tasks by Project Phase, Tasks by Status, Tasks by Project Phase/Status, Tasks by Impact/WBS, and Tasks by Phase/Impact/WBS.

John Collins; John M. Beck

2011-11-01T23:59:59.000Z

352

Health risks in perspective: Judging health risks of energy technologies  

Science Conference Proceedings (OSTI)

Almost daily, Americans receive reports from the mass news media about some new and frightening risk to health and welfare. Most such reports emphasize the newsworthiness of the risks -- the possibility of a crisis, disagreements among experts, how things happened, who is responsible for fixing them, how much will it cost, conflict among parties involved, etc. As a rule, the magnitudes of the risks, or the difficulty of estimating those magnitudes, have limited newsworthiness, and so they are not mentioned. Because of this emphasis in the news media, most people outside the risk assessment community must judge the relative significance of the various risks to which we all are exposed with only that information deemed newsworthy by reporters. This information is biased and shows risks in isolation. There is no basis for understanding and comparing the relative importance of risks among themselves, or for comparing one risk, perhaps a new or newly-discovered one, in the field of all risks. The purpose of this report is to provide perspective on the various risks to which we are routinely exposed. It serves as a basis for understanding the meaning of quantitative risk estimates and for comparing new or newly-discovered risks with other, better-understood risks. Specific emphasis is placed on health risks of energy technologies.

Rowe, M.D.

1992-09-18T23:59:59.000Z

353

Does Treatment Duration Affect Outcome After Radiotherapy for Prostate Cancer?  

SciTech Connect

Purpose: The protraction of external beam radiotherapy (RT) time is detrimental in several disease sites. In prostate cancer, the overall treatment time can be considerable, as can the potential for treatment breaks. We evaluated the effect of elapsed treatment time on outcome after RT for prostate cancer. Methods and Materials: Between April 1989 and November 2004, 1,796 men with prostate cancer were treated with RT alone. The nontreatment day ratio (NTDR) was defined as the number of nontreatment days divided by the total elapsed days of RT. This ratio was used to account for the relationship between treatment duration and total RT dose. Men were stratified into low risk (n = 789), intermediate risk (n = 798), and high risk (n = 209) using a single-factor model. Results: The 10-year freedom from biochemical failure (FFBF) rate was 68% for a NTDR <33% vs. 58% for NTDR {>=}33% (p = 0.02; BF was defined as a prostate-specific antigen nadir + 2 ng/mL). In the low-risk group, the 10-year FFBF rate was 82% for NTDR <33% vs. 57% for NTDR {>=}33% (p = 0.0019). The NTDR was independently predictive for FFBF (p = 0.03), in addition to T stage (p = 0.005) and initial prostate-specific antigen level (p < 0.0001) on multivariate analysis, including Gleason score and radiation dose. The NTDR was not a significant predictor of FFBF when examined in the intermediate-risk group, high-risk group, or all risk groups combined. Conclusions: A proportionally longer treatment duration was identified as an adverse factor in low-risk patients. Treatment breaks resulting in a NTDR of {>=}33% (e.g., four or more breaks during a 40-fraction treatment, 5 d/wk) should be avoided.

D'Ambrosio, David J. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Li Tianyu [Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, PA (United States); Horwitz, Eric M. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Chen, David Y.T. [Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Pollack, Alan [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Buyyounouski, Mark K. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States)], E-mail: mark.buyyounouski@fccc.edu

2008-12-01T23:59:59.000Z

354

Modelling environmental risk  

Science Conference Proceedings (OSTI)

As environmental issues have become increasingly important in economic research and policy for sustainable development, firms in the private sector have introduced environmental and social issues in conducting their business activities. Such behaviour ... Keywords: Asymmetry, Conditional volatility, Dow Jones Sustainability Indexes, Environmental risk, Environmental sustainability index, GARCH, GJR, Log-moment condition, Moment condition, Persistence, Shocks

Suhejla Hoti; Michael McAleer; Laurent L. Pauwels

2005-10-01T23:59:59.000Z

355

Waste management health risk assessment: A case study of a solid waste landfill in South Italy  

Science Conference Proceedings (OSTI)

An integrated risk assessment study has been performed in an area within 5 km from a landfill that accepts non hazardous waste. The risk assessment was based on measured emissions and maximum chronic population exposure, for both children and adults, to contaminated air, some foods and soil. The toxic effects assessed were limited to the main known carcinogenic compounds emitted from landfills coming both from landfill gas torch combustion (e.g., dioxins, furans and polycyclic aromatic hydrocarbons, PAHs) and from diffusive emissions (vinyl chloride monomer, VCM). Risk assessment has been performed both for carcinogenic and non-carcinogenic effects. Results indicate that cancer and non-cancer effects risk (hazard index, HI) are largely below the values accepted from the main international agencies (e.g., WHO, US EPA) and national legislation ( and ).

Davoli, E., E-mail: enrico.davoli@marionegri.i [Istituto di Ricerche Farmacologiche 'Mario Negri', Environmental Health Sciences Department, Via Giuseppe La Masa 19, 20156 Milano (Italy); Fattore, E.; Paiano, V.; Colombo, A.; Palmiotto, M. [Istituto di Ricerche Farmacologiche 'Mario Negri', Environmental Health Sciences Department, Via Giuseppe La Masa 19, 20156 Milano (Italy); Rossi, A.N.; Il Grande, M. [Progress S.r.l., Via Nicola A. Porpora 147, 20131 Milano (Italy); Fanelli, R. [Istituto di Ricerche Farmacologiche 'Mario Negri', Environmental Health Sciences Department, Via Giuseppe La Masa 19, 20156 Milano (Italy)

2010-08-15T23:59:59.000Z

356

Lung cancer epidemiology in New Mexico uranium miners  

SciTech Connect

This investigation assesses the health effects of radon progeny exposure in New Mexico uranium miners. Cumulative exposures sustained by most New Mexico miners are well below those received earlier in the Colorado Plateau. This project utilizes the research opportunity offered by New Mexico miners to address unresolved issues related to radon progeny exposure: (1) the lung cancer risk of lower levels of exposure, (2) interaction between radon progeny exposure and cigarette smoking in the causation of lung cancer, (3) the relationship between lung cancer histologic type and radon progeny exposure, and (4) possible effects of radon progeny exposure other than lung cancer. A cohort study of 3800 men with at least one year of underground uranium mining experience in New Mexico is in progress. Results are discussed.

Samet, J.M.

1991-11-01T23:59:59.000Z

357

Nested methylation-specific polymerase chain reaction cancer detection method  

DOE Patents (OSTI)

A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

2007-05-08T23:59:59.000Z

358

The Value Proposition for High Lifetime (p-type) and Thin Silicon Materials in Solar PV Applications: Preprint  

NLE Websites -- All DOE Office Websites (Extended Search)

Proposition for High Proposition for High Lifetime (p-type) and Thin Silicon Materials in Solar PV Applications Preprint Alan Goodrich, Michael Woodhouse, and Peter Hacke Presented at the 2012 IEEE Photovoltaic Specialists Conference Austin, Texas June 3-8, 2012 Conference Paper NREL/CP-6A20-55477 June 2012 NOTICE The submitted manuscript has been offered by an employee of the Alliance for Sustainable Energy, LLC (Alliance), a contractor of the US Government under Contract No. DE-AC36-08GO28308. Accordingly, the US Government and Alliance retain a nonexclusive royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for US Government purposes. This report was prepared as an account of work sponsored by an agency of the United States government.

359

Determination of the 5d6s 3D1 state lifetime and blackbody radiation clock shift in Yb  

E-Print Network (OSTI)

The Stark shift of the ytterbium optical clock transition due to room temperature blackbody radiation is dominated by a static Stark effect, which was recently measured to high accuracy [J. A. Sherman et al., Phys. Rev. Lett. 108, 153002 (2012)]. However, room temperature operation of the clock at 10^{-18} inaccuracy requires a dynamic correction to this static approximation. This dynamic correction largely depends on a single electric dipole matrix element for which theoretically and experimentally derived values disagree significantly. We determine this important matrix element by two independent methods, which yield consistent values. Along with precise radiative lifetimes of 6s6p 3P1 and 5d6s 3D1, we report the clock's blackbody radiation shift to 0.05% precision.

Beloy, K; Lemke, N D; Hinkley, N; Oates, C W; Ludlow, A D

2012-01-01T23:59:59.000Z

360

Literature review of the lifetime of DOE materials: Aging of plastic bonded explosives and the explosives and polymers contained therein  

SciTech Connect

There are concerns about the lifetime of the nation`s stockpile of high explosives (HEs) and their components. The DOE`s Core Surveillance and Enhanced Surveillance programs specifically target degradation of HE, binders, and plastic-bonded explosives (PBXs) for determination of component lifetimes and handling procedures. The principal goal of this project is to identify the decomposition mechanisms of HEs, plasticizers, and plastic polymer binders resulting from exposure to ionizing radiation, heat, and humidity. The primary HEs of concern are 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) and 1,3,5,7-tetranitro-1,3,5,7-tetraazocyclooctane (HMX). Hexahydro-1,3,5-triazine (RDX) is closely related to these two compounds and is also included in the literature review. Both Kel-F 800 and Estane are polymers of interest. A stabilizer, Irganox 1010, and an energetic plasticizer that is a blend of acetaldehyde 2,2-dinitropropyl acetal, are also of interest, but the focus of this report will be on the explosives and polymers. This presents a literature review that provides background on the synthesis, degradation, and techniques to analyze TATB, HMX, RDX, Kel-F 800, Estane, and the PBXs of these compounds. As there are many factors that can influence degradation of materials, the degradation discussion will be divided into sections based on each factor and how it might affect the degradation mechanism. The factors reviewed that influence the degradation of these materials are exposure to heat, UV- and {gamma}-irradiation, and the chemistry of these compounds. The report presents a recently compiled accounting of the available literature. 80 refs., 7 figs.

Burgess, C.E.; Woodyard, J.D. [West Texas A and M Univ., Canyon, TX (United States); Rainwater, K.A. [Texas Tech Univ., Lubbock, TX (United States); Lightfoot, J.M. [Pantex Plant, Amarillo, TX (United States); Richardson, B.R. [Engineered Carbons, Inc., Borger, TX (United States)

1998-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Cancer survivorship : understanding the issues faced by cancer survivors.  

E-Print Network (OSTI)

??International research on cancer survivorship has started to identify a range of issues that affect cancer survivors physically, mentally, emotionally and spiritually. These issues can… (more)

Hayward, Penelope Anne

2010-01-01T23:59:59.000Z

362

A system to test the effects of materials on the electron drift lifetime in liquid argon and observations on the effect of water  

SciTech Connect

A materials test system (MTS) has been developed at FNAL to assess the suitability of materials for use in a large liquid argon time projection chamber. During development of the MTS, it was noted that controlling the cryostat pressure with a 'raining' condenser reduced the electron drift lifetime in the liquid argon. The effect of condensing has been investigated using a series of passive materials to filter the condensate. We report the results of these studies and of tests on different candidate materials for detector construction. The inferred reduction of electron drift lifetime by water concentrations in the parts per trillion is of particular interest.

Andrews, R.; Jaskierny, W.; Jostlein, H.; Kendziora, C.; Pordes, S.; Tope, T.; /Fermilab

2009-07-01T23:59:59.000Z

363

Draft Risk Assessment Processes  

Science Conference Proceedings (OSTI)

A cyber security risk assessment process includes the characterization of assets. A thorough asset characterization process can lead to a more robust threat characterization. One means of enhancing the thoroughness of the asset-and-threat characterization processes is to improve the characterization mechanisms. This technical update supports this approach by providing the results of initial research and developing a framework to support further analysis.This project builds upon the work ...

2012-12-28T23:59:59.000Z

364

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

RAIS Risk Exposure Models for Radionuclides User's Guide RAIS Risk Exposure Models for Radionuclides User's Guide Note The RAIS presents this updated Risk calculator in response to the following: incorporating chemical-specific parameters from the lastest EPI release, addition of air as a media, and conversion to a new database structure. The previous RAIS Risk calculator presented Risks for radionuclides and chemcials together. Recent development of chemical and radionuclide exposure equations has necessitated that the RAIS separate the chemicals and the radionuclides. To calculate risks for chemicals, use the RAIS Risk Exposure Models for Chemicals calculator. Currently the agricultural equations for the RAIS chemical and radionuclide risk calculators are identical. The EPA's Preliminary Remediation Goals for

365

Probabilistic Risk Assessment - A Bibliography  

Science Conference Proceedings (OSTI)

Probabilistic risk analysis is an integration of failure modes and effects analysis (FEMA), fault tree analysis and other techniques to assess the potential for failure and to find ways to reduce risk. This bibliography references 160 documents in the ...

Program NASA Scientific and Technical Information

2000-07-01T23:59:59.000Z

366

Risk assessment handbook  

SciTech Connect

The Probabilistic Risk Assessment Unit at EG G Idaho has developed this handbook to provide guidance to a facility manager exploring the potential benefit to be gained by performance of a risk assessment properly scoped to meet local needs. This document is designed to help the manager control the resources expended commensurate with the risks being managed and to assure that the products can be used programmatically to support future needs in order to derive maximum beneflt from the resources expended. We present a logical and functional mapping scheme between several discrete phases of project definition to ensure that a potential customer, working with an analyst, is able to define the areas of interest and that appropriate methods are employed in the analysis. In addition the handbook is written to provide a high-level perspective for the analyst. Previously, the needed information was either scattered or existed only in the minds of experienced analysts. By compiling this information and exploring the breadth of knowledge which exists within the members of the PRA Unit, the functional relationships between the customers' needs and the product have been established.

Farmer, F.G.; Jones, J.L.; Hunt, R.N.; Roush, M.L.; Wierman, T.E.

1990-09-01T23:59:59.000Z

367

Risk assessment handbook  

SciTech Connect

The Probabilistic Risk Assessment Unit at EG&G Idaho has developed this handbook to provide guidance to a facility manager exploring the potential benefit to be gained by performance of a risk assessment properly scoped to meet local needs. This document is designed to help the manager control the resources expended commensurate with the risks being managed and to assure that the products can be used programmatically to support future needs in order to derive maximum beneflt from the resources expended. We present a logical and functional mapping scheme between several discrete phases of project definition to ensure that a potential customer, working with an analyst, is able to define the areas of interest and that appropriate methods are employed in the analysis. In addition the handbook is written to provide a high-level perspective for the analyst. Previously, the needed information was either scattered or existed only in the minds of experienced analysts. By compiling this information and exploring the breadth of knowledge which exists within the members of the PRA Unit, the functional relationships between the customers` needs and the product have been established.

Farmer, F.G.; Jones, J.L.; Hunt, R.N.; Roush, M.L.; Wierman, T.E.

1990-09-01T23:59:59.000Z

368

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

occupational inhalation exposure to nickel dust (primarily nickel subsulfate) at refineries has resulted in increased incidences of pulmonary and nasal cancer (NAS 1975,...

369

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

RAIS Chemical Risk Calculator RAIS Chemical Soil to Ground Water Calculator Radionuclide Calculators Preliminary Remediation Goals (PRGs) Radionuclide Calculator RAIS...

370

Arsenic in drinking water and lung cancer: A systematic review  

SciTech Connect

Exposure to inorganic arsenic via drinking water is a growing public health concern. We conducted a systematic review of the literature examining the association between arsenic in drinking water and the risk of lung cancer in humans. Towards this aim, we searched electronic databases for articles published through April 2006. Nine ecological studies, two case-control studies, and six cohort studies were identified. The majority of the studies were conducted in areas of high arsenic exposure (100 {mu}g/L) such as southwestern Taiwan, the Niigata Prefecture, Japan, and Northern Chile. Most of the studies reported markedly higher risks of lung cancer mortality or incidence in high arsenic areas compared to the general population or a low arsenic exposed reference group. The quality assessment showed that, among the studies identified, only four assessed arsenic exposure at the individual level. Further, only one of the ecological studies presented results adjusted for potential confounders other than age; of the cohort and case-control studies, only one-half adjusted for cigarette smoking status in the analysis. Despite these methodologic limitations, the consistent observation of strong, statistically significant associations from different study designs carried out in different regions provide support for a causal association between ingesting drinking water with high concentrations of arsenic and lung cancer. The lung cancer risk at lower exposure concentrations remains uncertain.

Celik, Ismail [Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara (Turkey); Gallicchio, Lisa [Prevention and Research Center, Mercy Medical Center (United States); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Boyd, Kristina; Lam, Tram K.; Matanoski, Genevieve [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Tao Xuguang [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Department of Occupational and Environmental Medicine, Johns Hopkins University School of Medicine (United States); Shiels, Meredith; Hammond, Edward [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Chen Liwei [Department of International Health, Center for Human Nutrition, Johns Hopkins University Bloomberg School of Public Health (United States); Robinson, Karen A. [Department of General Internal Medicine, Johns Hopkins University School of Medicine (United States); Caulfield, Laura E. [Department of International Health, Center for Human Nutrition, Johns Hopkins University Bloomberg School of Public Health (United States); Herman, James G. [Department of Oncology, Johns Hopkins University School of Medicine (United States); Guallar, Eliseo [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Alberg, Anthony J. [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Cancer Prevention and Control Program, Hollings Cancer Center, and Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina (United States)], E-mail: alberg@musc.edu

2008-09-15T23:59:59.000Z

371

Enterprise level IT risk management  

Science Conference Proceedings (OSTI)

Increasing IT budget and over-dependence of business on IT infra-structure makes risk management a critical component of enterprise management. The creation and sustenance of an IT risk management framework is one of the crucial and challenging tasks ... Keywords: enterprise level, information technology, risk management

Nadhirah Azizi; Khairuddin Hashim

2008-11-01T23:59:59.000Z

372

CALIFORNIA STATE UNIVERSITY, RISK MANAGEMENT  

E-Print Network (OSTI)

performance within the CSU System. #12;2004 ­ 2005 Risk Management Annual Report Page 3 · Chaired the CSU-04 2004-05 Fullerton System-Wide #12;2004 ­ 2005 Risk Management Annual Report Page 10 University · International travel · Facilities use · Deferred maintenance Working with the University's Risk Management

de Lijser, Peter

373

Belief-based risk analysis  

Science Conference Proceedings (OSTI)

This paper describes a method for risk analysis based on the approach used in CRAMM, but instead of using discrete measures for threats and vulnerabilities and look-up tables to derive levels of risk, it uses subjective beliefs about threats and vulnerabilities ... Keywords: belief calculus, risk analysis, security

Audun Jøsang; Daniel Bradley; Svein J. Knapskog

2004-01-01T23:59:59.000Z

374

NGNP Risk Management Database: A Model for Managing Risk  

Science Conference Proceedings (OSTI)

To facilitate the implementation of the Risk Management Plan, the Next Generation Nuclear Plant (NGNP) Project has developed and employed an analytical software tool called the NGNP Risk Management System (RMS). A relational database developed in Microsoft® Access, the RMS provides conventional database utility including data maintenance, archiving, configuration control, and query ability. Additionally, the tool’s design provides a number of unique capabilities specifically designed to facilitate the development and execution of activities outlined in the Risk Management Plan. Specifically, the RMS provides the capability to establish the risk baseline, document and analyze the risk reduction plan, track the current risk reduction status, organize risks by reference configuration system, subsystem, and component (SSC) and Area, and increase the level of NGNP decision making.

John Collins

2009-09-01T23:59:59.000Z

375

LPP Risk Management Plan | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Plan More Documents & Publications Software Development Risk Assessment High Risk Plan SC Introduction to Risk Management Energy.gov Careers & Internships For Staff &...

376

Cancer mortality among a group of fluorspar miners exposed to radon progeny  

SciTech Connect

A cohort study of the mortality experience (1950-1984) of 1,772 Newfoundland underground fluorspar miners occupationally exposed to high levels of radon daughters (mean dose = 382.8 working levels months) has been conducted. Observed numbers of cancers of the lung, salivary gland, and buccal cavity and pharynx were significantly elevated among these miners. A highly significant relation was noted between radon daughter exposure and risk of dying of lung cancer; the small numbers of salivary gland (n = 2) and buccal cavity and pharynx (n = 6) cancers precluded meaningful analysis of dose response. Attributable and relative risk coefficients for lung cancer were estimated as 6.3 deaths per working level month per million person-years and 0.9% per working level month, respectively. Relative risk coefficients were highest for those first exposed before age 20 years. Cigarette smokers had relative and attributable risk coefficients comparable to those of nonsmokers. Relative risks fell sharply with age, whereas attributable risks were lowest in the youngest and oldest age groups. The results suggest that efforts to raise existing occupational exposure standards may be inappropriate.

Morrison, H.I.; Semenciw, R.M.; Mao, Y.; Wigle, D.T.

1988-12-01T23:59:59.000Z

377

EMAB Risk Subcommittee Interim Report  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FIRST INTERIM REPORT TO THE ENVIRONMENTAL MANAGEMENT ADVISORY BOARD Incorporating Risk and Sustainability into Decision Making Submitted by the EMAB Risk Subcommittee December 3, 2012 Background: In December 2011, then Acting Assistant Secretary for Environmental Management David Huizenga, asked the Environmental Management Advisory Board (EMAB or Board) to establish a Risk Subcommittee. In February 2012, the Subcommittee's Work Plan was approved. Under the Work Plan, the purpose of the Subcommittee is to evaluate "risk-informed decision making," specifically whether the prioritization tool developed by the Consortium for Risk Evaluation with Stakeholder Participation (CRESP) for use at the Oak Ridge Reservation (Oak Ridge) is one that

378

Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the atomic bomb survivors study  

Science Conference Proceedings (OSTI)

Current lung cancer risk estimates after exposure to low-linear energy transfer radiation such as X rays are based on studies of people exposed to such radiation at high dose rates, for example the atomic bomb survivors. Radiobiology and animal experiments suggest that risks from exposure at low to moderate dose rates, for example medical diagnostic procedures, may be overestimated by such risk models, but data for humans to examine this issue are limited. In this paper we report on lung cancer mortality between 1950 and 1987 in a cohort of 64,172 Canadian tuberculosis patients, of whom 39% were exposed to highly fractionated multiple chest fluoroscopies leading to a mean lung radiation dose of 1.02 Sv received at moderate dose rates. These data have been used to estimate the excess relative risk per sievert of lung cancer mortality, and this is compared directly to estimates derived from 75,991 atomic bomb survivors. Based on 1,178 lung cancer deaths in the fluoroscopy study, there was no evidence of any positive association between risk and dose, with the relative risk at 1 Sv being 1.00 (95% confidence interval 0.94, 1.07), which contrasts with that based on the atomic bomb survivors, 1.60 (1.27, 1.99). The difference in effect between the two studies almost certainly did not arise by chance (P = 0.0001). This study provides strong support from data for humans for a substantial fractionation/dose-rate effect for low-linear energy transfer radiation and lung cancer risk. This implies that lung cancer risk from exposures to such radiation at present-day dose rates is likely to be lower than would be predicted by current radiation risk models based on studies of high-dose-rate exposures. 25 refs., 8 tabs.

Howe, G.R. [Univ. of Toronto, Ontario (Canada)

1995-06-01T23:59:59.000Z

379

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

Risk Exposure Models for Chemicals User's Guide Risk Exposure Models for Chemicals User's Guide 1. Introduction The purpose of this calculator is to assist Remedial Project Managers (RPMs), On Scene Coordinators (OSC's), risk assessors and others involved in decision-making at hazardous waste sites and to determine whether levels of contamination found at the site may warrant further investigation or site cleanup, or whether no further investigation or action may be required. The risk values presented on this site are chemical-specific values for individual contaminants in air, water, soil and biota that may warrant further investigation or site cleanup. It should be noted that the risks in this calculator are based upon human health risk and do not address potential ecological risk. Some sites in sensitive ecological settings may also need to be evaluated for potential

380

Observed Changes in the Lifetime and Amplitude of the Madden–Julian Oscillation Associated with Interannual ENSO Sea Surface Temperature Anomalies  

Science Conference Proceedings (OSTI)

The Madden–Julian oscillation (MJO) is analyzed using the reanalysis zonal wind– and satellite outgoing longwave radiation–based indices of Wheeler and Hendon for the 1974–2005 period. The average lifetime of the MJO events varies with season (36 ...

Benjamin Pohl; Adrian J. Matthews

2007-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Enhancement of electron lifetime in dye-sensitized solar cells using anodically grown TiO2 nanotube/nanoparticle composite photoanodes  

Science Conference Proceedings (OSTI)

Dye-sensitized solar cells (DSCs) based on TiO"2 nanotube/nanoparticle (NT/NP) composite photoanodes were fabricated including different NT content into the NP network. The NPs expose large surface area for the dye anchoring, while the incorporated nanotubes ... Keywords: Anodic oxidation, Charge transport, Dye-sensitized solar cell, Electron lifetime, TiO2 nanotubes

Andrea Lamberti, Adriano Sacco, Stefano Bianco, Marzia Quaglio, Diego Manfredi, Candido Fabrizio Pirri

2013-11-01T23:59:59.000Z

382

Measurement of D-D-bar mixing using the ratio of lifetimes for the decays D-->K- pi + and K+K-  

E-Print Network (OSTI)

We measure the rate of D0-D[over-bar] 0 mixing with the observable yCP=(?Kpi/?KK)-1, where ?KK and ?Kpi are, respectively, the mean lifetimes of CP-even D0-->K+K- and CP-mixed D0-->K-pi+ decays, using a data sample of ...

Fisher, Peter H.

383

Effects of Cu Diffusion from ZnTe:Cu/Ti Contacts on Carrier Lifetime of CdS/CdTe Thin Film Solar Cells: Preprint  

DOE Green Energy (OSTI)

We study the performance of CdS/CdTe thin film PV devices processed with a ZnTe:Cu/Ti contact to investigate how carrier lifetime in the CdTe layer is affected by Cu diffusion from the contact.

Gessert, T. A.; Metzger, W. K.; Asher, S. E.; Young, M. R.; Johnston, S.; Dhere, R. G.; Duda, A.

2008-05-01T23:59:59.000Z

384

Photovoltaic Degradation Risk: Preprint  

SciTech Connect

The ability to accurately predict power delivery over the course of time is of vital importance to the growth of the photovoltaic (PV) industry. Important cost drivers include the efficiency with which sunlight is converted into power, how this relationship changes over time, and the uncertainty in this prediction. An accurate quantification of power decline over time, also known as degradation rate, is essential to all stakeholders - utility companies, integrators, investors, and researchers alike. In this paper we use a statistical approach based on historical data to quantify degradation rates, discern trends and quantify risks related to measurement uncertainties, number of measurements and methodologies.

Jordan, D. C.; Kurtz, S. R.

2012-04-01T23:59:59.000Z

385

Reading the Tea Leaves: How Utilities in the West Are Managing Carbon Regulatory Risk in their Resource Plans  

Science Conference Proceedings (OSTI)

The long economic lifetime and development lead-time of many electric infrastructure investments requires that utility resource planning consider potential costs and risks over a lengthy time horizon. One long-term -- and potentially far-reaching -- risk currently facing the electricity industry is the uncertain cost of future carbon dioxide (CO2) regulations. Recognizing the importance of this issue, many utilities (sometimes spurred by state regulatory requirements) are beginning to actively assess carbon regulatory risk within their resource planning processes, and to evaluate options for mitigating that risk. However, given the relatively recent emergence of this issue and the rapidly changing political landscape, methods and assumptions used to analyze carbon regulatory risk, and the impact of this analysis on the selection of a preferred resource portfolio, vary considerably across utilities. In this study, we examine the treatment of carbon regulatory risk in utility resource planning, through a comparison of the most-recent resource plans filed by fifteen investor-owned and publicly-owned utilities in the Western U.S. Together, these utilities account for approximately 60percent of retail electricity sales in the West, and cover nine of eleven Western states. This report has two related elements. First, we compare and assess utilities' approaches to addressing key analytical issues that arise when considering the risk of future carbon regulations. Second, we summarize the composition and carbon intensity of the preferred resource portfolios selected by these fifteen utilities and compare them to potential CO2 emission benchmark levels.

Barbose, Galen; Wiser, Ryan; Phadke, Amol; Goldman, Charles

2008-02-01T23:59:59.000Z

386

Roles for Cardiac MyBP-C in Maintaining Myofilament Lattice Rigidity and Prolonging Myosin Cross-Bridge Lifetime  

Science Conference Proceedings (OSTI)

We investigated the influence of cardiac myosin binding protein-C (cMyBP-C) and its constitutively unphosphorylated status on the radial and longitudinal stiffnesses of the myofilament lattice in chemically skinned myocardial strips of the following mouse models: nontransgenic (NTG), effective null for cMyBP-C (t/t), wild-type cMyBP-C expressed into t/t (WT{sub t/t}), and constitutively unphosphorylated cMyBP-C (AllP{sub -t/t}). We found that the absence of cMyBP-C in the t/t and the unphosphorylated cMyBP-C in the AllP{sub -t/t} resulted in a compressible cardiac myofilament lattice induced by rigor not observed in the NTG and WT{sub t/t}. These results suggest that the presence and phosphorylation of the N-terminus of cMyBP-C provides structural support and radial rigidity to the myofilament lattice. Examination of myofilament longitudinal stiffness under rigor conditions demonstrated a significant reduction in cross-bridge-dependent stiffness in the t/t compared with NTG controls, but not in the AllP{sub -t/t} compared with WT{sub t/t} controls. The absence of cMyBP-C in the t/t and the unphosphorylated cMyBP-C in the AllP{sub -t/t} both resulted in a shorter myosin cross-bridge lifetime when myosin isoform was controlled. These data collectively suggest that cMyBP-C provides radial rigidity to the myofilament lattice through the N-terminus, and that disruption of the phosphorylation of cMyBP-C is sufficient to abolish this structural role of the N-terminus and shorten cross-bridge lifetime. Although the presence of cMyBP-C also provides longitudinal rigidity, phosphorylation of the N-terminus is not necessary to maintain longitudinal rigidity of the lattice, in contrast to radial rigidity.

Palmer, B.M.; Sadayappan, S.; Wang, Y.; Weith, A.E.; Previs, M.J.; Bekyarova, T.; Irving, T.C.; Robbins, J.; Maughan, D.W. (Vermont)

2011-10-06T23:59:59.000Z

387

Collateral Risk Analytics for Energy Trading and Portfolio Risk Management  

Science Conference Proceedings (OSTI)

This report describes the need for a strong collateral risk management function as an integral part of an energy company’s risk management program. It reviews the basics of margining and collateral both in over-the-counter markets and on exchanges. In addition, it details the technology available to measure collateral risk properly. Then it reviews the recent efforts to regulate OTC derivatives, the potential impact that it could have on energy companies’ management of cash collateral, and strategies tha...

2010-12-21T23:59:59.000Z

388

Predicting the Risk of Secondary Lung Malignancies Associated With Whole-Breast Radiation Therapy  

Science Conference Proceedings (OSTI)

Purpose: The risk of secondary lung malignancy (SLM) is a significant concern for women treated with whole-breast radiation therapy after breast-conserving surgery for early-stage breast cancer. In this study, a biologically based secondary malignancy model was used to quantify the risk of secondary lung malignancies (SLMs) associated with several common methods of delivering whole-breast radiation therapy (RT). Methods and Materials: Both supine and prone computed tomography simulations of 15 women with early breast cancer were used to generate standard fractionated and hypofractionated whole-breast RT treatment plans for each patient. Dose-volume histograms (DVHs) of the ipsilateral breast and lung were calculated for each patient on each plan. A model of spontaneous and radiation-induced carcinogenesis was used to determine the relative risks of SLMs for the different treatment techniques. Results: A higher risk of SLMs was predicted for supine breast irradiation when compared with prone breast irradiation for both the standard fractionation and hypofractionation schedules (relative risk [RR] = 2.59, 95% confidence interval (CI) = 2.30-2.88, and RR = 2.68, 95% CI = 2.39-2.98, respectively). No difference in risk of SLMs was noted between standard fractionation and hypofractionation schedules in either the supine position (RR = 1.05, 95% CI = 0.97-1.14) or the prone position (RR = 1.01, 95% CI = 0.88-1.15). Conclusions: Compared with supine whole-breast irradiation, prone breast irradiation is associated with a significantly lower predicted risk of secondary lung malignancy. In this modeling study, fractionation schedule did not have an impact on the risk of SLMs in women treated with whole-breast RT for early breast cancer.

Ng, John, E-mail: jon9024@nyp.org [Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Shuryak, Igor [Center for Radiological Research, Columbia University Medical Center, New York, NY (United States); Xu Yanguang; Clifford Chao, K.S. [Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Brenner, David J. [Center for Radiological Research, Columbia University Medical Center, New York, NY (United States); Burri, Ryan J. [Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States)

2012-07-15T23:59:59.000Z

389

Testing and Analysis for Lifetime Prediction of Crystalline Silicon PV Modules Undergoing Degradation by System Voltage Stress: Preprint  

DOE Green Energy (OSTI)

Acceleration factors are calculated for crystalline silicon PV modules under system voltage stress by comparing the module power during degradation outdoors to that in accelerated testing at three temperatures and 85% relative humidity. A lognormal analysis is applied to the accelerated lifetime test data considering failure at 80% of the initial module power. Activation energy of 0.73 eV for the rate of failure is determined, and the probability of module failure at an arbitrary temperature is predicted. To obtain statistical data for multiple modules over the course of degradation in-situ of the test chamber, dark I-V measurements are obtained and transformed using superposition, which is found well suited for rapid and quantitative evaluation of potential-induced degradation. It is determined that shunt resistance measurements alone do not represent the extent of power degradation. This is explained with a two-diode model analysis that shows an increasing second diode recombination current and ideality factor as the degradation in module power progresses. Failure modes of the modules stressed outdoors are examined and compared to those stressed in accelerated tests.

Hacke, P.; Smith, R.; Terwiliger, K.; Glick, S.; Jordan, D.; Johnston, S.; Kempe, M.; Kurtz, S.

2012-07-01T23:59:59.000Z

390

Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987  

Science Conference Proceedings (OSTI)

This report presents, for the first time, comprehensive data on the incidence of solid cancer and risk estimates for A-bomb survivors in the extended Life Span Study (LSS-E85) cohort. Among 79,972 individuals, 8613 first primary solid cancers were diagnosed between 1958 and 1987. As part of the standard registration process of the Hiroshima and Nagasaki tumor registries, cancer cases occurring among members of the LSS-E85 cohort were identified using a computer linkage system supplemented by manual searches. Special efforts were made to ensure complete case ascertainment, data quality and data consistency in the two cities. For all sites combined, 75% of the cancers were verified histologically, 6% were diagnosed by direct observation, 8% were based on a clinical diagnosis, and 12.6% were ascertained by death certificate only. A standard set of analyses was carried out for each of the organs and organ systems considered. Depending on the cancer site, Dosimetry System 1986 (DS86) organ or kerma doses were used for computing risk estimates. Analyses were based on a general excess relative risk model (the background rate times one plus the excess relative risk). Analyses carried out for each site involved fitting the background model with no dose effect, a linear dose-response model with no effect modifiers, a linear-quadratic dose-response model with no effect modifiers, and a series of linear dose-response models that included each of the covariates (sex, age at exposure, time since exposure, attained age and city) individually as effect modifiers. Because the tumor registries ascertain cancers in the registry catchment areas only, an adjustment was made for the effects of migration. In agreement with prior LSS findings, a statistically significant excess risk for all solid cancers was demonstrated. 116 refs., 8 figs., 78 tabs.

Thompson, D.E. (Radiation Effects Research Foundation, Nagasaki (Japan) George Washington Univ., Rockville, MD (United States) Radiation Effects Research Foundation, Hiroshima (Japan)); Soda, Midori (Radiation Effects Research Foundation, Nagasaki (Japan)); Izumi, Shizue; Mabuchi, Kiyohiko (Radiation Effects Research Foundation, Hiroshima (Japan)); Ron, E.; Tokunaga, Masayoshi (Radiation Effects Research Foundation, Hiroshima (Japan) National Cancer Institute, Bethesda, MD (United States)); Ochikubo, Sachio (Hiroshima City Medical Association (Japan)); Sugimoto, Sumio (Hiroshima Prefectural Medical Association (Japan)); Ikeda, Takayoshi (Nagasaki Univ. Medical School (Japan)); Terasaki, Masayuki (Nagasaki City Medical Association (Japan)) (and others)

1994-02-01T23:59:59.000Z

391

Medical & Risk-related Research Archive of Science Articles  

NLE Websites -- All DOE Office Websites (Extended Search)

Search News Archive Search News Archive Advanced Search Search Tips Medical & Risk-related Research Computer Simulations Point Way to New Finding About the Immune System Secrets Of Drug Resistance Revealed New Breast Cancer Gene Found That Can Affect Cell Growth Controls New Bioactive Metal Coating Allows Metal Implants To Bond With Bone Online National Health Survey Seeks to Sign Up Millions Heading Off Terrorism, Scientists Model Airflow Transport Faster, Better Way to Compute Medical Models from Noisy Images Promising New Treatment for Brain Cancer on the Horizon New Sensor Provides First Instant Test for Toxic E. Coli Organism History of Nuclear Medicine: From Radioisotopes to Medical Imaging Water Purification System Has Vast Potential to Save Lives in Third World Exercise and Not Genetics Is Major Determinant of Weight, Study

392

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

Risk Assessment Documents - ORR Risk Assessment Documents - ORR Bullet Baseline Risk Assessments Bullet Remedial Investigation/Feasibility Study Environmental Assessment Report South Campus Facility, Oak Ridge Tenn [DOE/OR/02-1274&D] Bullet Baseline Risk Assessment for Lower East Fork Poplar Creek [DOE/OR/1119 & D2 & V2] Bullet Remedial Investigation/ Feasibility Study Report for Lower Watts Bar Reservoir Operable Unit [DOE/OR/01 1282 & D1] [ORNL/ER-2] Bullet The Utility of Existing Data Conducting a CERCLA Baseline Risk Assessment for Lower Watts Bar Reservoir (draft) [ORNL/ER-?] Bullet East Fork Poplar Creek Sewer Line Beltway Remedial Investigation Report [DOE/OR/02-1119&D2] Bullet Screening Risk Assessments Bullet Preliminary Assessment of Radiation Doses to the Public from Cesium

393

Electrogenerated Chemiluminescence and Fluorescence Lifetime Spatial Heterogeneity of Poly (2-methoxy-5-(2-ethylhexyloxy)-1, 4-phenylenevinylene) in Presence of [6,6]-phenyl-C61-butyric Acid Methyl Ester  

SciTech Connect

In this paper, we studied the luminescence property and fluorescence lifetime mapping of MEH-PPV/PCBM system by using electrogenerated chemiluminescence (ECL) and time-correlated single photo counting (TC-SPC) technologies. The ECL results showed that the oxidation peak of MEH-PPV near 0.7 V (vs. SCE) and ECL response of films shifted positively towards 1.2 V when in the presence of PCBM. At the same time, the oxidation peak current density of MEH-PPV increases while the ECL response decreased with the loading of PCBM in the composite films. The fluorescence lifetime images clearly show that the lifetime fluctuation is effected by different substrates and MEH-PPV/PCBM ratios. Meanwhile, the lifetime of MEH-PPV decreases with the increasing of film thickness. The lifetimes of MEH-PPV films on TiO2 substrate are lower than them of films on cover slips.

Geng, Hongwei; Pan, Shanlin; Hu, Dehong

2013-04-01T23:59:59.000Z

394

Relative risks of energy sources  

Science Conference Proceedings (OSTI)

This paper compares the risks associated with various energy sources in an attempt to demonstrate the relative safety of nuclear energy. (JEF)

Haire, M.J.

1990-01-01T23:59:59.000Z

395

Pollutant Exposure and Health Risk  

NLE Websites -- All DOE Office Websites (Extended Search)

TEMcKone@lbl.gov (510) 486-6163 Links Exposure and Risk Assessment Group Batteries and Fuel Cells Buildings Energy Efficiency Electricity Grid Energy Analysis Energy...

396

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

U.S. EPA, Washington, D.C. 1992. Risk Assessment Forum. Wildlife Exposure Factors Handbook. Vol. I. United Staes Environmental Protection Agency. Office of Research and...

397

ORISE: Crisis and Risk Communication  

NLE Websites -- All DOE Office Websites (Extended Search)

and Risk Communication Because a natural disaster, act of terrorism or other public emergency can happen without notice, having a planned, coordinated communication effort is...

398

HPV & head and neck cancer: a descriptive update  

E-Print Network (OSTI)

similar to tobacco smoke but actually has a greater concentration of the aromatic poly-carbon carcinogens found in cigarette smoke. Fur- thermore, cannabis is usually smoked unfiltered, allowing a greater concentration of toxin unfettered access... implicated in the aetiology of HNSCC, especially a low consumption of fibre and vita- mins in the form of fresh fruit and vegetables [11]. Oral hygiene and the state of dentition have also been linked to an increased risk of developing oro-pharyngeal cancer...

Goon, Peter K C; Stanley, Margaret A; Ebmeyer, Jorg; Steinstraesser, Lars; Upile, Tahwinder; Jerjes, Waseem; Bernal-Sprekelsen, Manuel; Gorner, Martin; Sudhoff, Holger H

2009-10-14T23:59:59.000Z

399

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

A mice. Cancer Res. 36:1744-1747. (Cited in U.S. EPA, 1990). Tipton, I.H.; Stewart, P.L.; Dickson, J. 1969. Title not given. Health Physics 9:109-145. (Cited in Friberg and...

400

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

ATSDR, 1990) Purde, M. and S. Etlin. 1980. Cancer cases among workers in the Estonia oil shale processing industry. In: Health Implications of New Energy Technologies, W.N. Rom...

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401

The Risk Assessment Information System  

NLE Websites -- All DOE Office Websites (Extended Search)

hydrocarbons in newborn mice." Cancer Lett. 34: 15-20. Lide, D.R., Ed. 1991. CRC Handbook of Chemistry and Physics, 1991-1992, 72nd ed. Boca Raton, FL, p. 3-96. Sellakumar,...

402

LED Lifetime Measurements  

Science Conference Proceedings (OSTI)

... at a time,” Zong says, providing information about how ... DOE's Energy Star program requires accreditation of ... products available on market, and then ...

2013-08-16T23:59:59.000Z

403

Optimistic biases in public perceptions of the risk from radon  

SciTech Connect

Survey data were obtained from a random sample of 657 homeowners in New Jersey and also from 141 homeowners who had already monitored their homes for radon. People who had not tested tended to believe that they were less at risk than their neighbors, and they interpreted ambiguous predictors of home radon levels in ways that supported their beliefs of below-average risk. Residents who had already tested their homes were relatively accurate about the probability of health effects. In both groups less than half of those who knew that radon can cause lung cancer were willing to admit that it would be serious if they suffered health effects from this source. The optimistic biases of the public may hamper attempts to encourage home radon monitoring and to promote appropriate mitigation measures in homes with elevated radon concentrations.

Weinstein, N.D.; Klotz, M.L.; Sandman, P.M.

1988-07-01T23:59:59.000Z

404

Software products for risk assessment  

Science Conference Proceedings (OSTI)

For assessing risks in all environments it is often necessary to use a systematic approach of modeling and simulation with the aim to simplify this process in the framework of designing new technological lines, machines, equipment and processes. Also ... Keywords: crisis management, risk assessment, software products

Jozef Ristvej; Tomas Lovecek

2011-11-01T23:59:59.000Z

405

Equipment Risk and Performance Assessment  

Science Conference Proceedings (OSTI)

This report introduces the basis for understanding, developing, and applying a new set of practical, condition-based risk models for substation equipment. Because of the great variety of risks encountered in the power delivery industry and the diversity in utility equipment and business practices, the focus at this stage of the project is at the conceptual level.

2010-12-23T23:59:59.000Z

406

A Detailed Analysis and Monte Carlo Simulation of the Neutron Lifetime Experiment S. Arzumanov et al., Phys. Lett. B 483 (2000) 15  

E-Print Network (OSTI)

We performed a detailed analysis and the Monte Carlo simulation of the neutron lifetime experiment [S. Arzumanov et al., Phys. Lett. B 483 (2000) 15] because of the strong disagreement by 5.6 standard deviations between the results of this experiment and our experiment [A. Serebrov et al., Phys. Lett. B 605 (2005) 72]. We found a few effects which were not taken into account in the experiment [S. Arzumanov et al., Phys. Lett. B 483 (2000) 15]. The possible correction is -5.5 s with uncertainty of 2.4 s which comes from initial data knowledge. We assume that after taking into account this correction the result of work [S. Arzumanov et al., Phys. Lett. B 483 (2000) 15] for neutron lifetime 885.4 +/- 0.9stat +/- 0.4syst s could be corrected to 879.9 +/- 0.9stat +/- 2.4syst s.

Fomin, A K

2010-01-01T23:59:59.000Z

407

Measurement of the B_d0 lifetime using B_d0 to J/psi K0_S decays at Dzero  

SciTech Connect

This thesis describes a measurement of the B{sub d}{sup 0} lifetime in the decay to (J/{psi}K{sub S}{sup 0}), using 114 pb{sup -1} of data collected by the D0 experiment at the Tevatron from October 15, 2002, to June 10, 2003. The measurement is motivated by the tests of the Standard Model that it makes possible. These include tests of Heavy Quark Effective Theory predicting B-meson lifetimes, and of the complex phase in the CKM-matrix as the source of CP-violation in B{sub d}{sup 0} decays to (J/{psi}K{sub S}{sup 0}).

Balm, Paul W.; /Amsterdam U.

2004-12-01T23:59:59.000Z

408

Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990  

Science Conference Proceedings (OSTI)

This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation. The follow-up is extended by the 5 years 1986-1990, and analysis includes an additional 10,500 survivors with recently estimated radiation doses. Together these extensions add about 550,000 person-years of follow-up. The cohort analyzed consists of 86,572 subjects, of which about 60% have dose estimates of at least 0.005 Sv. During 1950-1990 there have been 3086 and 4741 cancer deaths for the less than and greater than 0.005 Sv groups, respectively. It is estimated that among these there have been approximately 420 excess cancer deaths during 19509-1990, of which about 85 were due to leukemia, For cancers other than leukemia (solid cancers), about 25% of the excess deaths in 1950-1990 occurred during the last 5 years; for those exposed as children this figure is nearly 50%. For leukemia only about 3% of the excess deaths in 1950-1990 occurred in th last 5 years. Whereas most of the excess for leukemia occurred in the first 15 years after exposure, for solid cancers the pattern of excess risk in apparently more like alife-long elevation of the natural age-specific cancer risk. 29 refs., 8 figs., 19 tabs.

Pierce, D.A.; Shimizu, Y.; Preston, D.L. [Radiation Effects Research Foundation, Hiroshima (Japan)] [and others

1996-07-01T23:59:59.000Z

409

Probabilistic Assessment of Failure Risk in Gas Turbine Discs.  

E-Print Network (OSTI)

?? Gas turbine discs are heavily loaded due to centrifugal and thermal loads and are therefore designed for a service lifetime specified in hours and… (more)

Forsberg, Fredrik

2008-01-01T23:59:59.000Z

410

Second Malignant Neoplasms in Digestive Organs After Childhood Cancer: A Cohort-Nested Case-Control Study  

SciTech Connect

Purpose: Cancers of the digestive system constitute a major risk for childhood cancer survivors treated with radiotherapy once they reach adulthood. The aim of this study was to determine therapy-related risk factors for the development of a second malignancy in the digestive organs (SMDO) after a childhood cancer. Methods and Materials: Among 4,568 2-year survivors of a childhood solid cancer diagnosed before 17 years of age at eight French and British centers, and among 25,120 patients diagnosed as having a malignant neoplasm before the age of 20 years, whose data were extracted from the Nordic Cancer Registries, we matched 58 case patients (41 men and 17 women) of SMDO and 167 controls, in their respective cohort, for sex, age at first cancer, calendar year of occurrence of the first cancer, and duration of follow-up. The radiation dose received at the site of each second malignancy and at the corresponding site of its matched control was estimated. Results: The risk of developing a SMDO was 9.7-fold higher in relation to the general populations in France and the United Kingdom. In the case-control study, a strong dose-response relationship was estimated, compared with that in survivors who had not received radiotherapy; the odds ratio was 5.2 (95% CI, 1.7-16.0) for local radiation doses between 10 and 29 Gy and 9.6 (95% CI, 2.6-35.2) for doses equal to or greater than 30 Gy. Chemotherapy was also found to increase the risk of developing SMDO. Conclusions: This study confirms that childhood cancer treatments strongly increase the risk of SMDO, which occur only after a very long latency period.

Tukenova, Markhaba; Diallo, Ibrahima [Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, INSERM, Villejuif (France); University Paris Sud 11, UMRS, Villejuif (France); Gustave Roussy Institute, Villejuif (France); Anderson, Harald [Department of Cancer Epidemiology, Lund University, Lund (Sweden); Hawkins, Mike [Center for Childhood Cancer Survivor Studies, Department of Public Health and Epidemiology, University of Birmingham, Birmingham (United Kingdom); Garwicz, Stanislaw [Childhood Cancer Research Center, University Children's Hospital, Lund (Sweden); Sankila, Risto [Finnish Cancer Registry, Helsinki (Finland); El Fayech, Chiraz [Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, INSERM, Villejuif (France); University Paris Sud 11, UMRS, Villejuif (France); Gustave Roussy Institute, Villejuif (France); Winter, Dave [Center for Childhood Cancer Survivor Studies, Department of Public Health and Epidemiology, University of Birmingham, Birmingham (United Kingdom); Rubino, Carole [Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, INSERM, Villejuif (France); University Paris Sud 11, UMRS, Villejuif (France); Gustave Roussy Institute, Villejuif (France); Adjadj, Elisabeth [Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, INSERM, Villejuif (France); University Paris Sud 11, UMRS, Villejuif (France); Gustave Roussy Institute, Villejuif (France); Curie Institute, Paris (France); Haddy, Nadia; Oberlin, Odile [Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, INSERM, Villejuif (France); University Paris Sud 11, UMRS, Villejuif (France); Gustave Roussy Institute, Villejuif (France); Moller, Torgil [Department of Cancer Epidemiology, Lund University, Lund (Sweden); Langmark, Froydis [Finnish Cancer Registry, Helsinki (Finland); and others

2012-03-01T23:59:59.000Z

411

Capital Requirements, Risk Measures and Comonotonicity  

E-Print Network (OSTI)

In this paper we examine and summarize properties of several well-known risk measures, with special attention given to the class of distortion risk measures. We investigate the relationship between these risk measures and theories of choice under risk. We also consider the problem of evaluating risk measures for sums of nonindependent random variables and propose approximations based on the concept of comonotonicity.

Jan Dhaene; Steven Vanduffel; Qihe Tang; Marc J. Goovaerts; Rob Kaas; David Vyncke; Robkaas Davidvyncke

2004-01-01T23:59:59.000Z

412

Financial risk measurement with imprecise probabilities  

Science Conference Proceedings (OSTI)

Although financial risk measurement is a largely investigated research area, its relationship with imprecise probabilities has been mostly overlooked. However, risk measures can be viewed as instances of upper (or lower) previsions, thus letting us apply ... Keywords: Coherent and convex risk measures, Dilation, Envelope theorems, Imprecise previsions, Natural extension, Risk measures, Shortfall, Value-at-Risk (VaR)

Paolo Vicig

2008-09-01T23:59:59.000Z

413

Profiling risk sensibility through association rules  

Science Conference Proceedings (OSTI)

In the last recent years several approaches to risk assessment and risk management have been adopted to reduce the potential for specific risks in working environments. A safety culture has also developed to let workers acquire knowledge and understanding ... Keywords: Association rules, Frequent patterns, Risk perception, Risk propensity

Beatrice Lazzerini; Francesco Pistolesi

2013-04-01T23:59:59.000Z

414

Airport risk assessment: a probabilistic approach  

Science Conference Proceedings (OSTI)

Risk reduction is one of the key objectives pursued by transport safety policies. Particularly, the formulation and implementation of transport safety policies needs the systematic assessment of the risks, the specification of residual risk targets and ... Keywords: risk assessment methodology, risk management, safety civil aviation

L. Guerra; T. Murino; E. Romano

2008-05-01T23:59:59.000Z

415

Risk-based decision-making: A reality at the INEL  

SciTech Connect

Risk Analysis and Risk Management are major components of the Idaho National Engineering Laboratory`s (INEL`s) environmental restoration and waste management program. These tools help define responsible and cost-effective approaches to address potential human health and environmental risks from past operational practices. These techniques along with stake holder involvement, play a key role in the decision-making process which involves the US Department of Energy Idaho Operations Office (DOE), the US Environmental Protection Agency Region 10 (EPA), and the State of Idaho Department of Health and Welfare (IDHW), hereafter referred to as the agencies. An example of how this process works is Pad A, an above-ground mixed waste disposal site composed mainly of transuranic-contaminated evaporation pond salts. The site was constructed in 1972 for the disposal of solid radioactive wastes. A Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) baseline risk assessment was conducted to determine the incremental cancer risk and potential for adverse health effects to the public and the impacts to the environment if no action was performed. The risk characterization indicated that the carcinogenic risk for current and future hypothetical scenarios was below or within the NCP acceptable risk range. There was a potential 10 year window for an adverse health effect to an infant from nitrate contamination of the groundwater in about 250 years. Based on these results, a responsible and sound decision was reached to maintain and recontour the existing soil cover and to perform monitoring to confirm modeling assumptions.

Halford, V.E.; Nitschke, R.L. [Lockheed Idaho Technologies Co., Idaho Falls, ID (United States); Hula, G.A. [USDOE Idaho Operations Office, Idaho Falls, ID (United States)

1994-12-31T23:59:59.000Z

416

Security risk assessment: toward a comprehensive practical risk management  

Science Conference Proceedings (OSTI)

This paper introduces a unique approach to a more integrated security risk assessment SRA. This is formalised based on the proven mathematical methods described in various articles in the literature and combined with the work developed by the author. ...

Danilo Valeros Bernardo

2012-01-01T23:59:59.000Z

417

Proteomics for cancer biomarker discovery  

E-Print Network (OSTI)

Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, ...

Volchenboum, Samuel Louis

2007-01-01T23:59:59.000Z

418