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1

CANCER RISKS AM I AT RISK?  

E-Print Network [OSTI]

CANCER RISKS AM I AT RISK? It is often hard to explain why one person develops cancer and another does not. There are risk factors that could increase a person's likelihood of developing cancer, however, some people may have many of these risk factors and never get cancer. When thinking about your

Hardy, Christopher R.

2

Estimating radiogenic cancer risks  

SciTech Connect (OSTI)

This document presents a revised methodology for EPA`s estimation of cancer risks due to low-LET radiation exposures in light of information that has become available since the publication of BIER III, especially new information on the Japanese atomic bomb survivors. For most cancer sites, the risk model is one in which the age-specific relative risk coefficients are obtained by taking the geometric mean of coefficients derived from the atomic bomb survivor data employing two different methods for transporting risks from Japan to the U.S. (multiplicative and NIH projection methods). Using 1980 U.S. vital statistics, the risk models are applied to estimate organ-specific risks, per unit dose, for a stationary population.

NONE

1994-06-01T23:59:59.000Z

3

Supervised Machine Learning Algorithms for Early Detection of Oral Epithelial Cancer Using Fluorescence Lifetime Imaging Microscopy  

E-Print Network [OSTI]

In this study, the clinical potential of the endogenous multispectral Fluorescence lifetime imaging microscopy (FLIM) was investigated to objectively detect oral cancer. To this end, in vivo FLIM imaging was performed on a hamster cheek pouch model...

Lee, Joohyung

2014-08-06T23:59:59.000Z

4

Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk  

E-Print Network [OSTI]

cigarette smoking, and the risk of breast cancer. Cancerand breast cancer risk. JAMA Ambrosone, C.B. , Kropp, S. ,genotypes, and breast cancer risk: pooled analysis and meta-

2009-01-01T23:59:59.000Z

5

Identifying Risk Groups Associated with Colorectal Cancer  

E-Print Network [OSTI]

Identifying Risk Groups Associated with Colorectal Cancer Jie Chen1 , Hongxing He1 , Huidong Jin1 of identifying and describing risk groups for colorectal cancer (CRC) from population based administrative health are applied to the colorectal cancer patients' profiles in contrast to background pa- tients' profiles

Jin, Huidong "Warren"

6

WON EXPOSURE AND LUNG CANCER RISK  

E-Print Network [OSTI]

As information on indoor air quality accumulated * it became apparent that radon and its progeny are invariably present in indoor environments and that concentrations may reach unacceptably high levels. The lung cancer excess anong miners exposed to radon progeny raised concern that exposure to radon progeny might also cause lung cancer in the general population. This presentation first provides an ovemiew of radon daughter carcinogenesis, and then reviews the recent BEIR IV report. The report described a statistical model * based on analysis of data from four studies of miners, for estimating the lung cancer risk associated with exposure to radon progeny. Tbe analyses showed that the risk of radon exposure declines with time since exposure and with increasing age. The BEIR IV committee concluded that radon progeny and cigarette smoking interact in a multiplicative fashion and that exposure-dose relationships are similar for exposure in homes and in mines.

unknown authors

7

Sports activities and risk of testicular cancer  

E-Print Network [OSTI]

Summary.-The relationship of testicular seminoma with several factors was explored using a case-control study. Previously recognized associations with cryptorchidism and infantile inguinal hernia were confirmed and relationships were also found with cycling and horse-riding. These findings represent the first relationships of testicular cancer with well-defined postnatal risk factors. TESTICULAR CANCER is now the most common neoplasm in men aged 25-34 in England and Wales (Davies, 1981) and follows only non-melanoma skin cancer in Canada (Statistics Canada, 1980). Mortality in young men has been rising during this century in a number of countries (Davies, 1981; Grumet & MacMahon, 1958). Similar increases in incidence have been reported by several cancer registries for the age range 15-30 (Muir & Nectoux, 1978; Schottenfeld et al., 1980; Clemmesen, 1969; Petersen & Lee, 1972). Current estimates of incidence in British Columbia indicate that approximately 1 in 400 males will develop testicular cancer (Cancer Registry, 1975). The majority of studies of the epidemiology of testicular tumours have used routinely collected data to analyse the effects of factors such as social class, marital status, geography, racial group and religious preference. Case-control studies have analysed factors such as cryptorchidism and other prenatal conditions. Where it was examined, these studies have shown that, while differences exist in the age-specific incidence, treatment and prognosis of seminoma compared to other types of testicular cancer, the relationship to known risk factors is similar (Morrison, 1976b; Graham et al., 1977). The present report examines a number of characteristics of childhood and adolescence in a case-control study of all patients treated for seminoma of the testis at a regional treatment centre in the period 1970-77.

A. J. Coldman; J. M. Elwooda; R. P. Gallagher; Nottingham Nottingham

1982-01-01T23:59:59.000Z

8

Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study  

SciTech Connect (OSTI)

Purpose: To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials: Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results: During the time period of the study, 23 cases of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion: Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies.

Boukheris, Houda [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel S. [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stratton, Kayla L. [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States)] [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States); Smith, Susan A.; Weathers, Rita [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hammond, Sue [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States)] [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States); Mertens, Ann C. [Department of Pediatrics, Emory University, Atlanta, Georgia (United States)] [Department of Pediatrics, Emory University, Atlanta, Georgia (United States); Donaldson, Sarah S. [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States)] [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States); Armstrong, Gregory T.; Robison, Leslie L. [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States)] [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States); Neglia, Joseph P. [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States)] [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States); Inskip, Peter D., E-mail: inskippe@mail.nih.gov [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)

2013-03-01T23:59:59.000Z

9

Cancer risk estimates from radiation therapy for heterotopic ossification prophylaxis after total hip arthroplasty  

SciTech Connect (OSTI)

Purpose: Heterotopic ossification (HO) is a frequent complication following total hip arthroplasty. This study was conducted to calculate the radiation dose to organs-at-risk and estimate the probability of cancer induction from radiotherapy for HO prophylaxis.Methods: Hip irradiation for HO with a 6 MV photon beam was simulated with the aid of a Monte Carlo model. A realistic humanoid phantom representing an average adult patient was implemented in Monte Carlo environment for dosimetric calculations. The average out-of-field radiation dose to stomach, liver, lung, prostate, bladder, thyroid, breast, uterus, and ovary was calculated. The organ-equivalent-dose to colon, that was partly included within the treatment field, was also determined. Organ dose calculations were carried out using three different field sizes. The dependence of organ doses upon the block insertion into primary beam for shielding colon and prosthesis was investigated. The lifetime attributable risk for cancer development was estimated using organ, age, and gender-specific risk coefficients.Results: For a typical target dose of 7 Gy, organ doses varied from 1.0 to 741.1 mGy by the field dimensions and organ location relative to the field edge. Blocked field irradiations resulted in a dose range of 1.4–146.3 mGy. The most probable detriment from open field treatment of male patients was colon cancer with a high risk of 564.3 × 10{sup ?5} to 837.4 × 10{sup ?5} depending upon the organ dose magnitude and the patient's age. The corresponding colon cancer risk for female patients was (372.2–541.0) × 10{sup ?5}. The probability of bladder cancer development was more than 113.7 × 10{sup ?5} and 110.3 × 10{sup ?5} for males and females, respectively. The cancer risk range to other individual organs was reduced to (0.003–68.5) × 10{sup ?5}.Conclusions: The risk for cancer induction from radiation therapy for HO prophylaxis after total hip arthroplasty varies considerably by the treatment parameters, organ site in respect to treatment volume and patient's gender and age. The presented risk estimates may be useful in the follow-up studies of irradiated patients.

Mazonakis, Michalis; Berris, Theoharris; Damilakis, John [Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, 71003 Iraklion, Crete (Greece)] [Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, 71003 Iraklion, Crete (Greece); Lyraraki, Efrossyni [Department of Radiotherapy and Oncology, University Hospital of Iraklion, 71110 Iraklion, Crete (Greece)] [Department of Radiotherapy and Oncology, University Hospital of Iraklion, 71110 Iraklion, Crete (Greece)

2013-10-15T23:59:59.000Z

10

New perspectives on the cancer risks of trichloroethylene, its metabolites, and chlorination by-products  

SciTech Connect (OSTI)

Scientific developments in the 1990`s have important implications for the assessment of cancer risks posed by exposures to trichloroethylene (TCE). These new developments include: epidemiological studies; experimental studies of TCE carcinogenicity, metabolism and metabolite carcinogenicity; applications of new physiologically based pharmacokinetic (PBPK) models for TCE; and new pharmacodynamic data obtained for TCE and its rhetabolites. Following a review of previous assessments of TCE carcinogenicity, each of these new sets of developments is summarized. The new epidemiological data do not provide evidence of TCE carcinogenicity in humans, and the new pharmacodynamic data support the hypothesis that TCE carcinogenicity is caused by TCE-induced cytotoxicity. Based on this information, PBPK-based estimates for likely no-adverse effect levels (NOAELs) for human exposures to TCE are calculated to be 16 ppb for TCE in air respired 24 hr/day, and 210 ppb for TCE in drinking water. Cancer risks of zero are predicted for TCE exposures below these calculated NOAELs. For comparison, hypothetical cancer risks posed by lifetime ingestive and multiroute household exposures to TCE in drinking water, at the currently enforced Maximum Contaminant Level (MCL) concentration of 5 ppb are extrapolated from animal bioassay data using a conservative, linear dose-response model. These TCE-related risks are compared to corresponding ones associated with concentrations of chlorination by-products (CBP) in household water. It is shown that, from the standpoint of comparative hypothetical cancer risks, based on conservative linear dose-response extrapolations, there would likely be no health benefit, and more likely a possible health detriment, associated with any switch from a household water supply containing <375 ppb TCE to one containing CBP at levels corresponding to the currently proposed 80-ppb MCL for total trihalomethanes.

Bogen, K.T. [Lawrence Livermore National Lab., CA (United States); Slone, T.; Gold, L.S.; Manley, N.; Revzan, K. [Lawrence Berkeley Lab., CA (United States)

1994-12-08T23:59:59.000Z

11

Radiation Dose and Subsequent Risk for Stomach Cancer in Long-term Survivors of Cervical Cancer  

SciTech Connect (OSTI)

Purpose: To assess the dose–response relationship for stomach cancer after radiation therapy for cervical cancer. Methods and Materials: We conducted a nested, matched case–control study of 201 cases and 378 controls among 53,547 5-year survivors of cervical cancer diagnosed from 1943 to 1995, from 5 international, population-based cancer registries. We estimated individual radiation doses to the site of the stomach cancer for all cases and to corresponding sites for the matched controls (overall mean stomach tumor dose, 2.56 Gy, range 0.03-46.1 and after parallel opposed pelvic fields, 1.63 Gy, range 0.12-6.3). Results: More than 90% of women received radiation therapy, mostly with external beam therapy in combination with brachytherapy. Stomach cancer risk was nonsignificantly increased (odds ratio 1.27-2.28) for women receiving between 0.5 and 4.9 Gy to the stomach cancer site and significantly increased at doses ?5 Gy (odds ratio 4.20, 95% confidence interval 1.41-13.4, P{sub trend}=.047) compared with nonirradiated women. A highly significant radiation dose–response relationship was evident when analyses were restricted to the 131 cases (251 controls) whose stomach cancer was located in the middle and lower portions of the stomach (P{sub trend}=.003), whereas there was no indication of increasing risk with increasing dose for 30 cases (57 controls) whose cancer was located in the upper stomach (P{sub trend}=.23). Conclusions: Our findings show for the first time a significant linear dose–response relationship for risk of stomach cancer in long-term survivors of cervical cancer.

Kleinerman, Ruth A., E-mail: kleinerr@mail.nih.gov [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Holowaty, Eric [Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario (Canada); Hall, Per [Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm (Sweden); Pukkala, Eero [Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki (Finland); Vaalavirta, Leila [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Stovall, Marilyn; Weathers, Rita [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Aleman, Berthe M.P. [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands); Kaijser, Magnus [Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm (Sweden); Andersson, Michael [Department of Oncology, Copenhagen University Hospital, Copenhagen (Denmark); Storm, Hans [Cancer Prevention and Documentation, Danish Cancer Society, Copenhagen (Denmark); Joensuu, Heikki [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, Iowa (United States); and others

2013-08-01T23:59:59.000Z

12

RESEARCH Open Access Analysis of primary risk factors for oral cancer  

E-Print Network [OSTI]

RESEARCH Open Access Analysis of primary risk factors for oral cancer from select US states , Michelle Chino3 , Karl Kingsley1* Abstract Objectives: To examine the primary risk factor for oral cancer in oral cancer incidence and mortality. Methods: Population-based data on oral cancer morbidity

Ahmad, Sajjad

13

Improved Cancer Risk Assessment Using Text Mining Name Mode of Action Precision  

E-Print Network [OSTI]

Improved Cancer Risk Assessment Using Text Mining Name Mode of Action Precision Aflatoxin B1 for risk assessment purposes Cancer Risk Assessment examines existing scientific evidence to determine the relationship between exposure to a chemical and the likelihood of developing cancer from that exposure. Text

Korhonen, Anna

14

A New Formula for Prostate Cancer Lymph Node Risk  

SciTech Connect (OSTI)

Introduction: The successful treatment of prostate cancer depends on the accurate estimation of the risk of regional lymph node (LN) involvement. The Roach formula (RF) has been criticized as overestimating LN risk. A modification of the RF has been attempted by other investigators using simplified adjustment ratios: the Nguyen formula (NF). Methods and Materials: The National Cancer Institute Surveillance, Epidemiology, and End Results database was investigated for patients treated in 2004 through 2006 for whom at least 10 LN were examined at radical prostatectomy, cT1c or cT2 disease, and prostate-specific antigen (PSA) <26 ng/ml (N = 2,930). The Yale formula (YF) was derived from half of the sample (n = 1,460), and validated in the other half (n = 1,470). Results: We identified 2,930 patients. Only 4.6% of patients had LN+, and 72.6% had cT1c disease. Gleason (GS) 8-10 histology was found in 14.4% of patients. The YF for prediction of %LN+ risk is [GS - 5]x [PSA/3 + 1.5 x T], where T = 0, 1, and 2 for cT1c, cT2a, and cT2b/cT2c. Within each strata of predicted %LN+ risk, the actual %LN+ was closest to the YF. Using a >15% risk as an indicator of high-risk disease, the YF had increased sensitivity (39.0% vs. 13.6%) compared with the NF, without a significant reduction in specificity (94.9% vs. 98.8%). The NF was overly restrictive of the high-risk group, with only 2% of patients having a >15% risk of LN+ by that formula. Conclusion: The YF performed better than the RF and NF and was best at differentiating patients at high risk for LN+ disease.

Yu, James B., E-mail: james.b.yu@yale.ed [Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT (United States); Yale Cancer Center, New Haven, CT (United States); Makarov, Danil V. [Robert Wood Johnson Clinical Scholars Program, Yale School of Medicine, New Haven, CT (United States); Section of Urology, Yale School of Medicine, New Haven, CT (United States); Department of Veterans Affairs Connecticut Healthcare System, West Haven, CT (United States); Gross, Cary [Robert Wood Johnson Clinical Scholars Program, Yale School of Medicine, New Haven, CT (United States); Department of Internal Medicine, Yale School of Medicine, New Haven, CT (United States)

2011-05-01T23:59:59.000Z

15

Environmental Factors and Breast Cancer Risk For millions of women whose lives  

E-Print Network [OSTI]

on the ways disease themselves, and are likelyin which environmental exposures increase breast cancer risk will be analyzed for pesticides, heavy metals and other environmental chemicals that may be linked to breast cancerEnvironmental Factors and Breast Cancer Risk For millions of women whose lives have been affected

Bezrukov, Sergey M.

16

Identifying Men Diagnosed With Clinically Localized Prostate Cancer Who are at High Risk for Death From Prostate Cancer  

E-Print Network [OSTI]

Identifying Men Diagnosed With Clinically Localized Prostate Cancer Who are at High Risk for Death From Prostate Cancer Anthony V. D'Amico,* Ming Hui-Chen, Andrew A. Renshaw, Brenda Sussman, Kimberly A), Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, Department

Chen, Ming-Hui

17

E-Print Network 3.0 - anal cancer risk Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: anal cancer risk Page: << < 1 2 3 4 5 > >> 1 Summer Internship Results Symposium Text Mining...

18

Serum 25-hydroxyvitamin D and risk of breast cancer  

E-Print Network [OSTI]

and prevention of breast cancer: pooled analysis. AnticancerBray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA-Cancer J Clin. 2005;55(2):74-108. American Cancer

Mohr, Sharif Burgette

2012-01-01T23:59:59.000Z

19

Unanticipated potential cancer risk near metal recycling facilities  

SciTech Connect (OSTI)

Metal recycling is an important growing industry. Prior to this study, area sources consisting of metal recycling facilities fell in a category of limited regulatory scrutiny because of assumed low levels of annual emissions. Initiating with community complaints of nuisance from smoke, dust and odor, the Houston Department of Health and Human Services (HDHHS) began a monitoring program outside metal recycler facilities and found metal particulates in outdoor ambient air at levels which could pose a carcinogenic human health risk. In a study of five similar metal recycler facilities which used a torch cutting process, air downwind and outside the facility was sampled for eight hours between 6 and 10 times each over 18 months using a mobile laboratory. Ten background locations were also sampled. Iron, manganese, copper, chromium, nickel, lead, cobalt, cadmium and mercury were detected downwind of the metal recyclers at frequencies ranging from 100% of the time for iron to 2% of the time for mercury. Of these metals, chromium, nickel, lead, cobalt, cadmium and mercury were not detected in any sample in the background. Two pairs of samples were analyzed for total chromium and hexavalent chromium to establish a ratio of the fraction of hexavalent chromium in total chromium. This fraction was used to estimate hexavalent chromium at all locations. The carcinogenic risk posed to a residential receptor from metal particulate matter concentrations in the ambient air attributed to the metal recyclers was estimated from each of the five facilities in an effort to rank the importance of this source and inform the need for further investigation. The total risk from these area sources ranged from an increased cancer risk of 1 in 1,000,000 to 6 in 10,000 using the 95th upper confidence limit of the mean of the carcinogenic metal particulate matter concentration, assuming the point of the exposure is the sample location for a residential receptor after accounting for wind direction and the number of shifts that could operate a year. Further study is warranted to better understand the metal air pollution levels in the community and if necessary, to evaluate the feasibility of emission controls and identify operational improvements and best management practices for this industry. This research adds two new aspects to the literature: identification of types and magnitude of metal particulate matter air pollutants associated with a previously unrecognized area source, metal recyclers and their potential risk to health. -- Highlights: • Air monitoring study in response to community complaints found metal contamination. • Metal recyclers found to potentially pose cancer from metal particulates • Chromium, nickel, cobalt and cadmium samples were detected in five metal recyclers. • These metals were not detected in background air samples. • Estimated increased cancer risk ranges from 1 in 1,000,000 to 8 in 10,000.

Raun, Loren, E-mail: raun@rice.edu [Department of Statistics, MS 138, Rice University, P.O. Box 1892, Houston, TX 77251-1892 (United States)] [Department of Statistics, MS 138, Rice University, P.O. Box 1892, Houston, TX 77251-1892 (United States); Pepple, Karl, E-mail: pepple.karl@epa.gov [State and Local Programs Group, Air Quality Policy Division, Office of Air Quality Planning and Standards, Policy, Analysis, and Communications Staff, Mail Drop C404-03, U.S. EPA, Research Triangle Park, NC 27711 (United States)] [State and Local Programs Group, Air Quality Policy Division, Office of Air Quality Planning and Standards, Policy, Analysis, and Communications Staff, Mail Drop C404-03, U.S. EPA, Research Triangle Park, NC 27711 (United States); Hoyt, Daniel, E-mail: hoyt.daniel@epa.gov [Air Surveillance Section, US EPA, Region 6, 6EN-AS, 1445 Ross Avenue, Dallas, TX 75202-2733 (United States)] [Air Surveillance Section, US EPA, Region 6, 6EN-AS, 1445 Ross Avenue, Dallas, TX 75202-2733 (United States); Richner, Donald, E-mail: Donald.Richner@houstontx.gov [Houston Department of Health and Human Services, Bureau of Pollution Control and Prevention, 7411 Park Place Blvd., Houston, TX 77087 (United States)] [Houston Department of Health and Human Services, Bureau of Pollution Control and Prevention, 7411 Park Place Blvd., Houston, TX 77087 (United States); Blanco, Arturo, E-mail: arturo.blanco@houstontx.gov [Pollution Control and Prevention, Environmental Health Division, Houston Department of Health and Human Services, 7411 Park Place Blvd., Houston, TX 77087 (United States)] [Pollution Control and Prevention, Environmental Health Division, Houston Department of Health and Human Services, 7411 Park Place Blvd., Houston, TX 77087 (United States); Li, Jiao, E-mail: jiao.li@rice.edu [Wiess School of Natural Science, Rice University, 6100 Main St., Houston, TX 77005 (United States)] [Wiess School of Natural Science, Rice University, 6100 Main St., Houston, TX 77005 (United States)

2013-07-15T23:59:59.000Z

20

Algorithms for Fluorescence Lifetime Microscopy and Optical Coherence Tomography Data Analysis: Applications for Diagnosis of Atherosclerosis and Oral Cancer  

E-Print Network [OSTI]

imaging (FLIM) with optical coherence tomography (OCT), for the diagnosis of atherosclerosis and oral cancer. FLIM is a fluorescence imaging technique that is capable of providing information about auto fluorescent tissue biomolecules. OCT on the other...

Pande, Paritosh

2014-05-16T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

A stochastic approach to risk assessment of hazardous waste sites  

E-Print Network [OSTI]

action at the site ~ modify preliminary remediation goals ~ help support the selection of the "no-action" remedial alternative, where appropriate ~ document the magnitude of risk at a site, and the primary causes of that risk Baseline risk... of the general approach for risk assessment at sites on the National Priority List (4, 5) This method recommends remedial action at the site when the calculated individual lifetime cancer risk at the site is above 1 in 10, 000. This calculated risk is assumed...

Arangath, Vishwanathan Vasu

1995-01-01T23:59:59.000Z

22

The sensitivity of the statistical procedures utilizing the Hartley-Sielken models to do low dose cancer risk assessment  

E-Print Network [OSTI]

(d) for a grid of t and d values. ) The distribution of T2 was taken to be exponential with p(T & t) = 1 -e 2 and either 3. 5 which implies a median time from onset to cancer caused death of . 2 (that is, 1/5 of a lifetime), or 1. 4 2 which implies... a median of . 5 (that is, 1/2 of a lifetime). These two values correspond respectively to "short" and "moderately long" median times from cancer onset to cancer caused death. (Table A. 3 indicates the percentiles of both distributions for T2...

Sabbagh, Mayna

1982-01-01T23:59:59.000Z

23

Urinary strontium and the risk of breast cancer: A case-control study in Guangzhou, China  

SciTech Connect (OSTI)

Strontium has been widely used in industries like electronic and pharmacy. It has a carcinogenic potential, however, and no study has been conducted to evaluate its effects on cancer risk. The aim of this study was to explore the possible association between strontium and breast cancer risk in a case-control study including 240 incident invasive breast cancer patients and 246 age-matched controls. We measured the urinary concentrations of strontium by inductively coupled plasma mass spectrometry, and conducted face-to-face interviews to obtain information on potential breast cancer risk factors. Multivariable analysis was used to estimate the association. Creatinine-adjusted levels [median (25th, 75th) {mu}g/g] of strontium were 155.59 (99.05, 230.70) in the breast cancer patients and 119.62 (81.97, 163.76) in the controls. Women in the highest tertile of strontium showed 124% increased risk of breast cancer, when compared with those in the lowest tertile after adjustment for the potential risk factors [OR (95% CI): 2.24 (1.42-3.81)]. This association was particularly strong for HER2 positive breast cancer [OR (95% CI): 10.92 (3.53-33.77)], and only occurred among premenopausal women. These results suggest a potential role of strontium in the development of breast cancer and urge further studies on the environmental contamination and the physiological and pathological mechanisms of strontium.

Chen, Li-Juan [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China)] [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); Tang, Lu-Ying [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China) [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630 (China); He, Jian-Rong [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China) [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); Guangzhou Women and Children's Medical Center, Guangzhou 510623 (China); Su, Yi; Cen, Yu-Ling; Yu, Dan-Dan [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China)] [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); Wu, Bang-Hua [The Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510300 (China)] [The Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510300 (China); Lin, Ying [The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080 (China)] [The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080 (China); Chen, Wei-Qing [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China)] [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); Song, Er-Wei, E-mail: songerwei02@yahoo.com.cn [The Second Affiliated Hospital, Sun Yat-sen University, 107 Yanjiang West, Guangzhou 510120 (China)] [The Second Affiliated Hospital, Sun Yat-sen University, 107 Yanjiang West, Guangzhou 510120 (China); Ren, Ze-Fang, E-mail: renzef@mail.sysu.edu.cn [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China)] [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China)

2012-01-15T23:59:59.000Z

24

E-Print Network 3.0 - aya cancer survivors Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the Rapid Increase in CT Usage? Summary: depicts lifetime cancer risks from a given low dose of radiation, based on results from A-bomb survivors... S, Funamoto S, Nishi N, Soda...

25

E-Print Network 3.0 - adult cancer survivors Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

adults. With regard to the radiation... depicts lifetime cancer risks from a given low dose of radiation, based on results from A-bomb survivors... S, Funamoto S, Nishi N, Soda...

26

Arsenic Methylation and Bladder Cancer Risk in CaseControl Studies in Argentina and the  

E-Print Network [OSTI]

Arsenic Methylation and Bladder Cancer Risk in Case­Control Studies in Argentina and the United's susceptibility to bladder cancer. Methods: Urinary methylation products were measured in subjects from Argentina (114 cases and 114 controls) and the United States (23 cases and 49 controls). Results: In Argentina

California at Berkeley, University of

27

EPA`s program for risk assessment guidelines: Cancer classification issues  

SciTech Connect (OSTI)

Issues presented are related to classification of weight of evidence in cancer risk assessments. The focus in this paper is on lines of evidence used in constructing a conclusion about potential human carcinogenicity. The paper also discusses issues that are mistakenly addressed as classification issues but are really part of the risk assessment process. 2 figs.

Wiltse, J. [Environmental Protection Agency, Washington, DC (United States)

1990-12-31T23:59:59.000Z

28

Risk Factors Associated With Secondary Sarcomas in Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study  

SciTech Connect (OSTI)

Purpose: Childhood cancer survivors have an increased risk of secondary sarcomas. To better identify those at risk, the relationship between therapeutic dose of chemotherapy and radiation and secondary sarcoma should be quantified. Methods and Materials: We conducted a nested case-control study of secondary sarcomas (105 cases, 422 matched controls) in a cohort of 14,372 childhood cancer survivors. Radiation dose at the second malignant neoplasm (SMN) site and use of chemotherapy were estimated from detailed review of medical records. Odds ratios (ORs) and 95% confidence intervals were estimated by conditional logistic regression. Excess odds ratio (EOR) was modeled as a function of radiation dose, chemotherapy, and host factors. Results: Sarcomas occurred a median of 11.8 years (range, 5.3-31.3 years) from original diagnosis. Any exposure to radiation was associated with increased risk of secondary sarcoma (OR = 4.1, 95% CI = 1.8-9.5). A dose-response relation was observed, with elevated risks at doses between 10 and 29.9 Gy (OR = 15.6, 95% CI = 4.5-53.9), 30-49.9 Gy (OR = 16.0, 95% CI 3.8-67.8) and >50 Gy (OR = 114.1, 95% CI 13.5-964.8). Anthracycline exposure was associated with sarcoma risk (OR = 3.5, 95% CI = 1.6-7.7) adjusting for radiation dose, other chemotherapy, and primary cancer. Adjusting for treatment, survivors with a first diagnosis of Hodgkin lymphoma (OR = 10.7, 95% CI = 3.1-37.4) or primary sarcoma (OR = 8.4, 95% CI = 3.2-22.3) were more likely to develop a sarcoma. Conclusions: Of the risk factors evaluated, radiation exposure was the most important for secondary sarcoma development in childhood cancer survivors; anthracycline chemotherapy exposure was also associated with increased risk.

Henderson, Tara O., E-mail: thenderson@peds.bsd.uchicago.edu [University of Chicago, Chicago, IL (United States); Rajaraman, Preetha [National Cancer Institute, Bethesda, MD (United States)] [National Cancer Institute, Bethesda, MD (United States); Stovall, Marilyn [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States)] [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States); Constine, Louis S. [University of Rochester, Rochester, NY (United States)] [University of Rochester, Rochester, NY (United States); Olive, Aliza [Drexel University, Philadelphia, PA (United States)] [Drexel University, Philadelphia, PA (United States); Smith, Susan A. [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States)] [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States); Mertens, Ann [Emory University, Atlanta, GA (United States)] [Emory University, Atlanta, GA (United States); Meadows, Anna [Children's Hospital of Philadelphia, Philadelphia, PA (United States)] [Children's Hospital of Philadelphia, Philadelphia, PA (United States); Neglia, Joseph P. [University of Minnesota, Minneapolis, MN (United States)] [University of Minnesota, Minneapolis, MN (United States); Hammond, Sue [Nationwide Children's Hospital, Columbus, OH (United States)] [Nationwide Children's Hospital, Columbus, OH (United States); Whitton, John [Fred Hutchinson Cancer Research Center, Seattle, WA (United States)] [Fred Hutchinson Cancer Research Center, Seattle, WA (United States); Inskip, Peter D. [National Cancer Institute, Bethesda, MD (United States)] [National Cancer Institute, Bethesda, MD (United States); Robison, Leslie L. [St. Jude Children's Research Hospital, Memphis, TN (United States)] [St. Jude Children's Research Hospital, Memphis, TN (United States); Diller, Lisa [Dana-Farber Cancer Institute/Children's Hospital Cancer Center, Boston, MA (United States)] [Dana-Farber Cancer Institute/Children's Hospital Cancer Center, Boston, MA (United States)

2012-09-01T23:59:59.000Z

29

Cancer risks from soil emissions of volatile organic compounds at the Lawrence Livermore National Laboratory  

SciTech Connect (OSTI)

The emission isolation flux chamber (EIFC) methodology was applied to Superfund investigations at the Lawrence Livermore National Laboratory Site 300 to determine if on-site workers were exposed to VOCs volatilizing from the subsurface and what, if any, health risks could be attributed to the inhalation of the VOCs volatilizing from the subsurface. During July and August of 1996, twenty, eighteen, and twenty six VOC soil vapor flux samples were collected in the Building 830, 832, and 854 areas, respectively using EIFCS. The VOC concentrations in the vapor samples were used to calculate soil flux rates which were used as input into an air dispersion model to calculate ambient air exposure-point concentrations. The exposure-point concentrations were compared to EPA Region IX Preliminary Remediation Goals (PRGs). Buildings 830 and 832 exposure-point concentrations were less then the PRGs therefore no cancer risks were calculated. The cancer risks for Building 854 ranged from 1.6 x 10{sup -7} to 2.1 x 10{sup -6}. The resultant inhalation cancer risks were all within the acceptable range, implying that on-site workers were not exposed to VOC vapors volatilizing from the subsurface soil that could have significant cancer risks. Therefore remediation in these areas would not be necessary.

Dibley, V. R., LLNL

1998-02-01T23:59:59.000Z

30

Radiation Exposure to Patient and Staff in Hepatic Chemoembolization: Risk Estimation of Cancer and Deterministic Effects  

SciTech Connect (OSTI)

The purpose of the study was to determine the risks of radiation-induced cancer and deterministic effects for the patient and staff in transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). Sixty-five patients with HCC underwent the first cycle of TACE. Thermoluminescence dosemeters and conversion factors were used to measure surface doses and to calculate organ doses and effective dose. For the patient, the risk of fatal cancer and severe genetic defect was in the magnitude of 10{sup -4} and 10{sup -5}, respectively. Five patients showed surface doses over the first lumbar vertebra exceeding 2000 mSv and 45 patients showed doses over the spine or the liver region above 500 mSv. The risk of fatal cancer and severe genetic defect for the radiologist and assistant was in the magnitude of 10{sup -7} to 10{sup -8}. They could exceed the threshold for lens opacity in the case of more than 490 and 1613 TACE yearly for a period of many years, respectively. Radiation dose could lead to local transient erythema and/or local depression of hematopoiesis in many patients after TACE. For the radiologist and assistant, risk of fatal cancer and genetic defect and lens opacity might arise when they perform interventions such as TACE intensively.

Hidajat, Nico, E-mail: nico.hidajat@gmx.de; Wust, Peter; Felix, Roland; Schroeder, Ralf Juergen [Charite Campus Virchow-Klinikum, Humboldt-University of Berlin, Department of Radiology (Germany)

2006-10-15T23:59:59.000Z

31

Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition  

E-Print Network [OSTI]

model adjusted for age, sex, energy (nonfat and fat sources), height, weight, work-related physical. Affiliations of authors: From the Nutrition and Hormones Group, International Agency for Research on Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark (AO, A. Tjønneland); Institut National de la Santé et

Paris-Sud XI, Université de

32

Cancer risk estimation in Belarussian children due to thyroid irradiation as a consequence of the Chernobyl nuclear accident  

SciTech Connect (OSTI)

The thyroid doses received by the juvenile population of Belarus following the Chernobyl accident ranged up to about 10 Gy. The thyroid cancer risk estimate recommended in NCRP Report No. 80 was used to predict the number of thyroid cancer cases among children during 1990-1992 in selected Belarussian regions and cities. The results obtained using this risk estimate show an excess of thyroid cancer cases being registered vs. the predicted cases. Thyroid cancer incidence rate among boys under investigation is higher than among girls in the postaccident period. The excess of the observed over the expected incidence in the general juvenile population is caused by the high thyroid cancer incidence rate among boys. These results, which can be considered part of the first stage of a thorough thyroid cancer risk estimation after the Chernobyl accident, demonstrate the critical need to complete these studies in depth. 6 refs., 5 figs., 3 tabs.

Buglova, E.; Kenigsberg, J.E.; Sergeeva, N.V. [Research Inst. of Radiation Medicine, Minsk (Belarus)

1996-07-01T23:59:59.000Z

33

Predicting the Risk of Pelvic Node Involvement Among Men With Prostate Cancer in the Contemporary Era  

SciTech Connect (OSTI)

Purpose: The 'Roach formula' for the risk of pelvic lymph node metastases [(2/3) * PSA + (Gleason score - 6) * 10] was developed in the early prostate-specific antigen (PSA) era. We examined the accuracy of this formula in contemporary patients. Methods: We included men in the Surveillance, Epidemiology, and End Results Registry with a diagnosis of clinical T1c-T4 prostate cancer in 2004 who had a surgical lymph node evaluation, Gleason score (typically from prostatectomy), and baseline PSA level (n = 9,387). Expected and observed rates of node positivity were compared. Results: Ninety-eight percent were clinical T1c/T2, and 97% underwent prostatectomy. Overall, 309 patients (3.29%) had positive lymph nodes. Roach scores overestimated the actual rate of positive lymph nodes in the derivation set by 16-fold for patients with Roach score less than or equal to 10%, by 7-fold for scores greater than 10-20%, and by approximately 2.5-fold for scores greater than 20%. Applying these adjustment factors to Roach scores in the validation data set yielded accurate predictions of risk. For those with Roach score less than or equal to 10%, adjusted expected risk was 0.2% and observed risk was 0.2%. For Roach score greater than 10-20%, adjusted expected risk was 2.0% and observed risk was 2.1%. For Roach score greater than 20-30%, adjusted expected risk was 9.7% and observed risk was 6.5%. For Roach score greater than 30-40%, adjusted expected risk was 13.9% and observed risk was 13.9%. Conclusion: Applied to contemporary patients with mainly T1c/T2 disease, the Roach formula appears to overestimate pelvic lymph node risk. The adjustment factors presented here should be validated by using biopsy Gleason scores and extended lymphadenectomies.

Nguyen, Paul L. [Harvard Radiation Oncology Program, Boston, MA (United States)], E-mail: pnguyen@LROC.harvard.edu; Chen, M.-H. [Department of Statistics, University of Connecticut, Storrs, CT (United States); Hoffman, Karen E. [Harvard Radiation Oncology Program, Boston, MA (United States); Katz, Matthew S. [Division of Radiation Oncology, Saints Medical Center, Lowell, MA (United States); D'Amico, Anthony V. [Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA (United States)

2009-05-01T23:59:59.000Z

34

Genetic polymorphism in three glutathione s-transferase genes and breast cancer risk  

SciTech Connect (OSTI)

The role of the glutathione S-transferase (GST) enzyme family is to detoxify environmental toxins and carcinogens and to protect organisms from their adverse effects, including cancer. The genes GSTM1, GSTP1, and GSTT1 code for three GSTs involved in the detoxification of carcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and benzene. In humans, GSTM1 is deleted in about 50% of the population, GSTT1 is absent in about 20%, whereas the GSTP1 gene has a single base polymorphism resulting in an enzyme with reduced activity. Epidemiological studies indicate that GST polymorphisms increase the level of carcinogen-induced DNA damage and several studies have found a correlation of polymorphisms in one of the GST genes and an increased risk for certain cancers. We examined the role of polymorphisms in genes coding for these three GST enzymes in breast cancer. A breast tissue collection consisting of specimens of breast cancer patients and non-cancer controls was analyzed by polymerase chain reaction (PCR) for the presence or absence of the GSTM1 and GSTT1 genes and for GSTP1 single base polymorphism by PCR/RFLP. We found that GSTM1 and GSTT1 deletions occurred more frequently in cases than in controls, and GSTP1 polymorphism was more frequent in controls. The effective detoxifier (putative low-risk) genotype (defined as presence of both GSTM1 and GSTT1 genes and GSTP1 wild type) was less frequent in cases than controls (16% vs. 23%, respectively). The poor detoxifier (putative high-risk) genotype was more frequent in cases than controls. However, the sample size of this study was too small to provide conclusive results.

Woldegiorgis, S.; Ahmed, R.C.; Zhen, Y.; Erdmann, C.A.; Russell, M.L.; Goth-Goldstein, R.

2002-04-01T23:59:59.000Z

35

Draft Genome Sequences of Helicobacter pylori Strains Isolated from Regions of Low and High Gastric Cancer Risk in Colombia  

E-Print Network [OSTI]

The draft genome sequences of six Colombian Helicobacter pylori strains are presented. These strains were isolated from patients from regions of high and low gastric cancer risk in Colombia and were characterized by ...

Sheh, Alexander

36

Uncertainties in Cancer Risk Coefficients for Environmental Exposure to Radionuclides. An Uncertainty Analysis for Risk Coefficients Reported in Federal Guidance Report No. 13  

SciTech Connect (OSTI)

Federal Guidance Report No. 13 (FGR 13) provides risk coefficients for estimation of the risk of cancer due to low-level exposure to each of more than 800 radionuclides. Uncertainties in risk coefficients were quantified in FGR 13 for 33 cases (exposure to each of 11 radionuclides by each of three exposure pathways) on the basis of sensitivity analyses in which various combinations of plausible biokinetic, dosimetric, and radiation risk models were used to generate alternative risk coefficients. The present report updates the uncertainty analysis in FGR 13 for the cases of inhalation and ingestion of radionuclides and expands the analysis to all radionuclides addressed in that report. The analysis indicates that most risk coefficients for inhalation or ingestion of radionuclides are determined within a factor of 5 or less by current information. That is, application of alternate plausible biokinetic and dosimetric models and radiation risk models (based on the linear, no-threshold hypothesis with an adjustment for the dose and dose rate effectiveness factor) is unlikely to change these coefficients by more than a factor of 5. In this analysis the assessed uncertainty in the radiation risk model was found to be the main determinant of the uncertainty category for most risk coefficients, but conclusions concerning the relative contributions of risk and dose models to the total uncertainty in a risk coefficient may depend strongly on the method of assessing uncertainties in the risk model.

Pawel, David [U.S. Environmental Protection Agency; Leggett, Richard Wayne [ORNL; Eckerman, Keith F [ORNL; Nelson, Christopher [U.S. Environmental Protection Agency

2007-01-01T23:59:59.000Z

37

Hypertension, antihypertensive medication use, and breast cancer risk in the California Teachers Study cohort  

E-Print Network [OSTI]

x ORIGINAL PAPER Hypertension, antihypertensive medicationthe association between hypertension, antihypertensive (AH)Information on history of hypertension and lifetime regular

2010-01-01T23:59:59.000Z

38

Margin on Gross Tumor Volume and Risk of Local Recurrence in Head-and-Neck Cancer  

SciTech Connect (OSTI)

Purpose: To determine whether the method or extent of construction of the high-dose clinical target volume (CTV) and high-dose planning target volume (PTV) in intensity-modulated radiation therapy (IMRT) for head-and-neck cancer are associated with an increased risk of locoregional failure. Materials and Methods: Patients with nasopharyngeal, oropharyngeal, oral cavity, hypopharyngeal, or laryngeal squamous cell carcinomas treated definitively with IMRT were included. All patients without local relapse had a minimum follow-up of 12 months. Median follow-up for all patients was 24 months. Treatment plans of 85 available patients were reviewed, and the gross tumor volume (GTV) to PTV expansion method was estimated. Results: The GTVs were expanded volumetrically in 71 of 85 patients, by a median of 15 mm (range, 4-25 mm). An anatomic component to the expansion of GTV was used in 14 of 85 patients. Eighteen patients failed locoregionally, for an actuarial locoregional control rate of 77.2% at 2 years. There was no significant difference in locoregional control between patients with GTVs expanded volumetrically vs. those with a component of anatomic expansion. In patients with GTVs expanded volumetrically, no increase in risk of local failure was seen in patients with a total GTV expansion of <=15 mm. Conclusion: In this retrospective study, there was not an increased risk of local failure using smaller margins or expanding GTVs volumetrically when treating head-and-neck cancer patients definitively with IMRT.

Caudell, Jimmy J.; Meredith, Ruby F.; Spencer, Sharon A.; Keene, Kimberley S.; Dobelbower, M. Christian [Department of Radiation Oncology, University of Alabama-Birmingham, Birmingham, AL (United States); Bonner, James A., E-mail: jabonner@uabmc.ed [Department of Radiation Oncology, University of Alabama-Birmingham, Birmingham, AL (United States)

2010-01-15T23:59:59.000Z

39

Estimating the risks of cancer mortality and genetic defects resulting from exposures to low levels of ionizing radiation  

SciTech Connect (OSTI)

Estimators for calculating the risk of cancer and genetic disorders induced by exposure to ionizing radiation have been recommended by the US National Academy of Sciences Committee on the Biological Effects of Ionizing Radiations, the UN Scientific Committee on the Effects of Atomic Radiation, and the International Committee on Radiological Protection. These groups have also considered the risks of somatic effects other than cancer. The US National Council on Radiation Protection and Measurements has discussed risk estimate procedures for radiation-induced health effects. The recommendations of these national and international advisory committees are summarized and compared in this report. Based on this review, two procedures for risk estimation are presented for use in radiological assessments performed by the US Department of Energy under the National Environmental Policy Act of 1969 (NEPA). In the first procedure, age- and sex-averaged risk estimators calculated with US average demographic statistics would be used with estimates of radiation dose to calculate the projected risk of cancer and genetic disorders that would result from the operation being reviewed under NEPA. If more site-specific risk estimators are needed, and the demographic information is available, a second procedure is described that would involve direct calculation of the risk estimators using recommended risk-rate factors. The computer program REPCAL has been written to perform this calculation and is described in this report. 25 references, 16 tables.

Buhl, T.E.; Hansen, W.R.

1984-05-01T23:59:59.000Z

40

Reproductive Status at First Diagnosis Influences Risk of Radiation-Induced Second Primary Contralateral Breast Cancer in the WECARE Study  

SciTech Connect (OSTI)

Purpose: Our study examined whether reproductive and hormonal factors before, at the time of, or after radiation treatment for a first primary breast cancer modify the risk of radiation-induced second primary breast cancer. Methods and Materials: The Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study is a multicenter, population-based study of 708 women (cases) with asynchronous contralateral breast cancer (CBC) and 1399 women (controls) with unilateral breast cancer. Radiotherapy (RT) records, coupled with anthropomorphic phantom simulations, were used to estimate quadrant-specific radiation dose to the contralateral breast for each patient. Rate ratios (RR) and 95% confidence intervals (CI) were computed to assess the relationship between reproductive factors and risk of CBC. Results: Women who were nulliparous at diagnosis and exposed to {>=}1 Gy to the contralateral breast had a greater risk for CBC than did matched unexposed nulliparous women (RR = 2.2; 95% CI, 1.2-4.0). No increased risk was seen in RT-exposed parous women (RR = 1.1; 95% CI, 0.8-1.4). Women treated with RT who later became pregnant (8 cases and 9 controls) had a greater risk for CBC (RR = 6.0; 95% CI, 1.3-28.4) than unexposed women (4 cases and 7 controls) who also became pregnant. The association of radiation with risk of CBC did not vary by number of pregnancies, history of breastfeeding, or menopausal status at the time of first breast cancer diagnosis. Conclusion: Nulliparous women treated with RT were at an increased risk for CBC. Although based on small numbers, women who become pregnant after first diagnosis also seem to be at an increased risk for radiation-induced CBC.

Brooks, Jennifer D., E-mail: brooksj@mskcc.org [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Boice, John D. [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States)] [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Reiner, Anne S. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Bernstein, Leslie [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States)] [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States); John, Esther M. [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States)] [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, IA (United States)] [Department of Epidemiology, University of Iowa, Iowa City, IA (United States); Mellemkjaer, Lene [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark)] [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark); Knight, Julia A. [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada)] [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada); Thomas, Duncan C.; Haile, Robert W. [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States)] [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Capanu, Marinela; Bernstein, Jonine L. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Shore, Roy E. [Department of Environmental Medicine, New York University, New York, NY (United States) [Department of Environmental Medicine, New York University, New York, NY (United States); Radiation Effects Research Foundation, Hiroshima (Japan)

2012-11-15T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Asbestos exposure--quantitative assessment of risk  

SciTech Connect (OSTI)

Methods for deriving quantitative estimates of asbestos-associated health risks are reviewed and their numerous assumptions and uncertainties described. These methods involve extrapolation of risks observed at past relatively high asbestos concentration levels down to usually much lower concentration levels of interest today--in some cases, orders of magnitude lower. These models are used to calculate estimates of the potential risk to workers manufacturing asbestos products and to students enrolled in schools containing asbestos products. The potential risk to workers exposed for 40 yr to 0.5 fibers per milliliter (f/ml) of mixed asbestos fiber type (a permissible workplace exposure limit under consideration by the Occupational Safety and Health Administration (OSHA) ) are estimated as 82 lifetime excess cancers per 10,000 exposed. The risk to students exposed to an average asbestos concentration of 0.001 f/ml of mixed asbestos fiber types for an average enrollment period of 6 school years is estimated as 5 lifetime excess cancers per one million exposed. If the school exposure is to chrysotile asbestos only, then the estimated risk is 1.5 lifetime excess cancers per million. Risks from other causes are presented for comparison; e.g., annual rates (per million) of 10 deaths from high school football, 14 from bicycling (10-14 yr of age), 5 to 20 for whooping cough vaccination. Decisions concerning asbestos products require participation of all parties involved and should only be made after a scientifically defensible estimate of the associated risk has been obtained. In many cases to date, such decisions have been made without adequate consideration of the level of risk or the cost-effectiveness of attempts to lower the potential risk. 73 references.

Hughes, J.M.; Weill, H.

1986-01-01T23:59:59.000Z

42

The Neutron Lifetime  

E-Print Network [OSTI]

The decay of the free neutron into a proton, electron, and antineutrino is the prototype semileptonic weak decay and the simplest example of nuclear beta decay. The nucleon vector and axial vector weak coupling constants G_V and G_A determine the neutron lifetime as well as the strengths of weak interaction processes involving free neutrons and protons that are important in astrophysics, cosmology, solar physics and neutrino detection. In combination with a neutron decay angular correlation measurement, the neutron lifetime can be used to determine the first element of the CKM matrix Vud. Unfortunately the two main experimental methods for measuring the neutron lifetime currently disagree by almost 4 sigma. I will present a brief review of the status of the neutron lifetime and prospects for the future.

F. E. Wietfeldt

2014-11-13T23:59:59.000Z

43

Causes of Death in Men With Prevalent Diabetes and Newly Diagnosed High- Versus Favorable-Risk Prostate Cancer  

SciTech Connect (OSTI)

Purpose: To determine whether prevalent diabetes mellitus (pDM) affects the presentation, extent of radiotherapy, or prostate cancer (PCa)-specific mortality (PCSM) and whether PCa aggressiveness affects the risk of non-PCSM, DM-related mortality, and all-cause mortality in men with pDM. Methods: Between October 1997 and July 2907, 5,279 men treated at the Chicago Prostate Cancer Center with radiotherapy for PCa were included in the study. Logistic and competing risk regression analyses were performed to assess whether pDM was associated with high-grade PCa, less aggressive radiotherapy, and an increased risk of PCSM. Competing risks and Cox regression analyses were performed to assess whether PCa aggressiveness described by risk group in men with pDM was associated with the risk of non-PCSM, DM-related mortality, and all-cause mortality. Analyses were adjusted for predictors of high-grade PCa and factors that could affect treatment extent and mortality. Results: Men with pDM were more likely (adjusted hazard ratio [AHR], 1.9; 95% confidence interval [CI], 1.3-2.7; p = .002) to present with high-grade PCa but were not treated less aggressively (p = .33) and did not have an increased risk of PCSM (p = .58) compared to men without pDM. Among the men with pDM, high-risk PCa was associated with a greater risk of non-PCSM (AHR, 2.2; 95% CI, 1.1-4.5; p = .035), DM-related mortality (AHR, 5.2; 95% CI, 2.0-14.0; p = .001), and all-cause mortality (AHR, 2.4; 95% CI, 1.2-4.7; p = .01) compared to favorable-risk PCa. Conclusion: Aggressive management of pDM is warranted in men with high-risk PCa.

D'Amico, Anthony V., E-mail: adamico@partners.or [Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA (United States); Braccioforte, Michelle H.; Moran, Brian J. [Department of Radiation Oncology, Prostate Cancer Foundation of Chicago, Westmont, IL (United States); Chen, Ming-Hui [Department of Statistics, University of Connecticut, Storrs, CT (United States)

2010-08-01T23:59:59.000Z

44

Causes of Mortality After Dose-Escalated Radiation Therapy and Androgen Deprivation for High-Risk Prostate Cancer  

SciTech Connect (OSTI)

Purpose: Men with high-risk prostate cancer have other competing causes of mortality; however, current risk stratification schema do not account for comorbidities. We aim to identify the causes of death and factors predictive for mortality in this population. Methods and Materials: A total of 660 patients with high-risk prostate cancer were treated with definitive high-dose external beam radiation therapy (?74 Gy) and androgen deprivation (AD) between 1996 and 2009 at a single institution. Cox proportional hazards regression analysis was conducted to determine factors predictive of survival. Results: The median radiation dose was 78 Gy, median duration of AD was 6 months, and median follow-up was 74 months. The 10-year overall survival (OS) was 60.6%. Prostate cancer was the leading single cause of death, with 10-year mortality of 14.1% (95% CI 10.7-17.6), compared with other cancers (8.4%, 95% CI 5.7-11.1), cardiovascular disease (7.3%, 95% CI 4.7-9.9), and all other causes (10.4%, 95% CI 7.2-13.6). On multivariate analysis, older age (HR 1.55, P=.002) and Charlson comorbidity index score (CS) ?1 (HR 2.20, P<.0001) were significant factors predictive of OS, whereas Gleason score, T stage, prostate-specific antigen, duration of AD, radiation dose, smoking history, and body mass index were not. Men younger than 70 years of age with CS = 0 were more likely to die of prostate cancer than any other cause, whereas older men or those with CS ?1 more commonly suffered non-prostate cancer death. The cumulative incidences of prostate cancer-specific mortality were similar regardless of age or comorbidities (P=.60). Conclusions: Men with high-risk prostate cancer are more likely to die of causes other than prostate cancer, except for the subgroup of men younger than 70 years of age without comorbidities. Only older age and presence of comorbidities significantly predicted for OS, whereas prostate cancer- and treatment-related factors did not.

Tendulkar, Rahul D., E-mail: tendulr@ccf.org [Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (United States); Hunter, Grant K. [Department of Radiation Oncology, Intermountain Healthcare, Salt Lake City, Utah (United States); Reddy, Chandana A.; Stephans, Kevin L.; Ciezki, Jay P.; Abdel-Wahab, May [Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (United States); Stephenson, Andrew J.; Klein, Eric A. [Department of Urology, Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio (United States); Mahadevan, Arul [Seacoast Cancer Center New Hampshire, Dover, New Hampshire (United States); Kupelian, Patrick A. [Department of Radiation Oncology, University of California Los Angeles Health System, Los Angeles, California (United States)

2013-09-01T23:59:59.000Z

45

Neutron LifetimeNeutron Lifetime IUCF Colloquium April 13,  

E-Print Network [OSTI]

Neutron LifetimeNeutron Lifetime IUCF Colloquium April 13, 2007 Albert Steyerl Department 940 878.5±0.8 885.7±0.8 new result neutronlifetime(),s year world average Neutron lifetime data #12 world average Neutron lifetime data A. Serebrov et al. 2005Storage of ultra-cold neutrons878.5 ±±±± 0

Steyerl, Albert

46

STOMACH CANCER 9. STOMACH CANCER  

E-Print Network [OSTI]

of association and strength of evidence Increases risk Decreases risk Convincing or probable Helicobacter pylori/obesity 9 1 Helicobacter and Cancer Collaborative Group, 2001; 2 International Agency for Research on Cancer

Paxton, Anthony T.

47

Reference computations of public dose and cancer risk from airborne releases of plutonium. Nuclear safety technical report  

SciTech Connect (OSTI)

This report presents results of computations of doses and the associated health risks of postulated accidental atmospheric releases from the Rocky Flats Plant (RFP) of one gram of weapons-grade plutonium in a form that is respirable. These computations are intended to be reference computations that can be used to evaluate a variety of accident scenarios by scaling the dose and health risk results presented here according to the amount of plutonium postulated to be released, instead of repeating the computations for each scenario. The MACCS2 code has been used as the basis of these computations. The basis and capabilities of MACCS2 are summarized, the parameters used in the evaluations are discussed, and results are presented for the doses and health risks to the public, both the Maximum Offsite Individual (a maximally exposed individual at or beyond the plant boundaries) and the population within 50 miles of RFP. A number of different weather scenarios are evaluated, including constant weather conditions and observed weather for 1990, 1991, and 1992. The isotopic mix of weapons-grade plutonium will change as it ages, the {sup 241}Pu decaying into {sup 241}Am. The {sup 241}Am reaches a peak concentration after about 72 years. The doses to the bone surface, liver, and whole body will increase slightly but the dose to the lungs will decrease slightly. The overall cancer risk will show almost no change over this period. This change in cancer risk is much smaller than the year-to-year variations in cancer risk due to weather. Finally, x/Q values are also presented for other applications, such as for hazardous chemical releases. These include the x/Q values for the MOI, for a collocated worker at 100 meters downwind of an accident site, and the x/Q value integrated over the population out to 50 miles.

Peterson, V.L.

1993-12-23T23:59:59.000Z

48

Establishment of a bioassay system for cancer risk assessment in energy technology  

SciTech Connect (OSTI)

Separate abstracts were prepared for 20 papers in this report. For several years the Department of Energy (DOE), Office of Health and Environmental Research (OHER), has supported a research program aimed at developing new experimental approaches for the improvement of cancer risk assessments. The central issue is to overcome the organizational, species and other barriers that make it difficult to extrapolate laboratory-based data to predict risk to man. Most of the participants at the meeting are involved in research aimed at understanding the mechanism(s) of chemical carcinogenesis. Complex mixtures of chemicals are associated with many energy technologies. DOE's initial program emphasis focused on semi-applied research aimed at quantitative evaluation of carcinogenic activity of complex materials. Since much progress has been made in DOE integrated technology-specific chemical-biological characterization studies, the number and kinds of chemicals of concern has been reduced to a relatively few well-defined classes. Although the classes of compounds seem to be unique to some of the synfuel technologies, they are quite similar to compounds of general interest, for example, poly-nuclear aromatic hydrocarbons. Special emphasis was placed on molecular and cellular dosimetry as one of the key requirements for quantitative comparison of effects at the cell level in vivo and in vitro. Although it is relatively easy to measure cell, tissue, organ and whole organism doses associated with radiation exposures, we are just learning how to do this for chemical agents. Several methods have been developed in the past several years which can be used.

Ts'o, P.O.P.; Bruce, S.A.; Brown, A. (eds.)

1983-09-01T23:59:59.000Z

49

Iodine-131 Releases from Radioactive Lanthanum Processing at the X-10 Site in Oak Ridge, Tennessee (1944-1956)- An Assessment of Quantities released, Off-Site Radiation Doses, and Potential Excess Risks of Thyroid Cancer, Volume 1  

SciTech Connect (OSTI)

In the early 1990s, concern about the Oak Ridge Reservation's past releases of contaminants to the environment prompted Tennessee's public health officials to pursue an in-depth study of potential off-site health effects at Oak Ridge. This study, the Oak Ridge dose reconstruction, was supported by an agreement between the U.S. Department of Energy (DOE) and the State of Tennessee, and was overseen by a 12-member panel appointed by Tennessee's Commissioner of Health. One of the major contaminants studied in the dose reconstruction was radioactive iodine, which was released to the air by X-10 (now called Oak Ridge National Laboratory) as it processed spent nuclear reactor fuel from 1944 through 1956. The process recovered radioactive lanthanum for use in weapons development. Iodine concentrates in the thyroid gland so health concerns include various diseases of the thyroid, such as thyroid cancer. The large report, ''Iodine-131 Releases from Radioactive Lanthanum Processing at the X-10 Site in Oak Ridge, Tennessee (1944-1956) - An Assessment of Quantities Released, Off-site Radiation Doses, and Potential Excess Risks of Thyroid Cancer,'' is in two volumes. Volume 1 is the main body of the report, and Volume 1A, which has the same title, consists of 22 supporting appendices. Together, these reports serve the following purposes: (1) describe the methodologies used to estimate the amount of iodine-131 (I-131) released; (2) evaluate I-131's pathway from air to vegetation to food to humans; (3) estimate doses received by human thyroids; (4) estimate excess risk of acquiring a thyroid cancer during ones lifetime; and (5) provide equations, examples of historical documents used, and tables of calculated values. Results indicate that females born in 1952 who consumed milk from a goat pastured a few miles east of X-10 received the highest doses from I-131 and would have had the highest risks of contracting thyroid cancer. Doses from cow's milk are considerably less . Detailed dose and risk estimates, and associated uncertainties, for other contaminants studied for the Oak Ridge dose reconstruction are presented in several other technical reports. One way to easily locate them in OSTI's Information Bridge is by searching the ''report number field'' for the number DOE/OR/21981*. Be sure to place the asterisk after the base number so your search can list the complete series of reports related to Oak Ridge Dose Reconstruction.

Apostoaei, A.I.; Burns, R.E.; Hoffman, F.O.; Ijaz, T.; Lewis, C.J.; Nair, S.K.; Widner, T.E.

1999-07-01T23:59:59.000Z

50

Treating radiation-induced trismus in head and neck cancer;Exercise intervention and risk structures.  

E-Print Network [OSTI]

??Abstract The overall aim of this thesis was to investigate the incidence of trismus in head and neck cancer (HNC) and to assess the treatment… (more)

Pauli, Nina

2015-01-01T23:59:59.000Z

51

Increased lung cancer risks are similar whether arsenic is ingested ALLAN H. SMITHa  

E-Print Network [OSTI]

and workers inhaling arsenic in copper smelters (IARC, 1980). At the same time that arsenic inhalation smelter workers inhaling arsenic, and a lung cancer case­control study involving ingestion of arsenic

California at Berkeley, University of

52

Clinical Trial Report: Eradication of Helicobacter pylori Reduces the Risk for Subsequent Gastric Cancer  

E-Print Network [OSTI]

Report: Eradication of Helicobacter pylori Reduces the RiskMeta-analysis: can Helicobacter pylori eradication treatmentet al. : Association of Helicobacter pylori infection with

Pisegna, Joseph R.; Surti, Bijal; Scott, David R.

2010-01-01T23:59:59.000Z

53

Runtime verification of object lifetime specifications  

E-Print Network [OSTI]

This thesis reports on the implementation of a runtime verification system for object lifetime specifications. This system is used to explore and evaluate the expressiveness object lifetime specifications. Object lifetime ...

Benjamin, Zev (Zev A.)

2009-01-01T23:59:59.000Z

54

Predicting risk for the appearance of melanoma.  

E-Print Network [OSTI]

for projecting the absolute risk of breast cancer. J NatlD, Gail MH, et al: Cancer risk prediction models: A workshopal model of breast cancer risk prediction and implications

Meyskens, Frank L Jr; Ransohoff, David F

2006-01-01T23:59:59.000Z

55

Pelvic Nodal Radiotherapy in Patients With Unfavorable Intermediate and High-Risk Prostate Cancer: Evidence, Rationale, and Future Directions  

SciTech Connect (OSTI)

Over the past 15 years, there have been three major advances in the use of external beam radiotherapy in the management of men with clinically localized prostate made. They include: (1) image guided (IG) three-dimensional conformal/intensity modulated radiotherapy; (2) radiation dose escalation; and (3) androgen deprivation therapy. To date only the last of these three advances have been shown to improve overall survival. The presence of occult pelvic nodal involvement could explain the failure of increased conformality and dose escalation to prolong survival, because the men who appear to be at the greatest risk of death from clinically localized prostate cancer are those who are likely to have lymph node metastases. This review discusses the evidence for prophylactic pelvic nodal radiotherapy, including the key trials and controversies surrounding this issue.

Morikawa, Lisa K. [The University of Texas, M. D. Anderson Cancer Center (United States); Memorial Sloan-Kettering Cancer Center (United States); Roach, Mack, E-mail: mroach@radonc.ucsf.ed [University of California San Francisco (UCSF), Helen Diller Family Comprehensive Cancer Center (United States)

2011-05-01T23:59:59.000Z

56

The Lifetime of Grand Design  

E-Print Network [OSTI]

The lifetime of the structure in grand design spiral galaxies is observationally ill-determined, but is essentially set by how accurately the pattern's rotation can be characterized by a single angular pattern speed. This paper derives a generalized version of the Tremaine-Weinberg method for observationally determining pattern speeds, in which the pattern speed is allowed to vary arbitrarily with radius. The departures of the derived pattern speed from a constant then provides a simple metric of the lifetime of the spiral structure. Application of this method to CO observations of NGC 1068 reveal that the pattern speed of the spiral structure in this galaxy varies rapidly with radius, and that the lifetime of the spiral structure is correspondingly very short. If this result turns out to be common in grand-design spiral galaxies, then these features will have to be viewed as highly transient phenomena.

M. R. Merrifield; R. J. Rand; S. E. Meidt

2005-11-02T23:59:59.000Z

57

Effect of induction chemotherapy on estimated risk of radiation pneumonitis in bulky non–small cell lung cancer  

SciTech Connect (OSTI)

Patients with bulky non–small cell lung cancer (NSCLC) may be at a high risk for radiation pneumonitis (RP) if treated with up-front concurrent chemoradiation. There is limited information about the effect of induction chemotherapy on the volume of normal lung subsequently irradiated. This study aims to estimate the reduction in risk of RP in patients with NSCLC after receiving induction chemotherapy. Between 2004 and 2009, 25 patients with Stage IV NSCLC were treated with chemotherapy alone (no surgery or radiation therapy [RT]) and had computed tomography (CT) scans before and after 2 cycles of chemotherapy. Simulated RT plans were created for the prechemotherapy and postchemotherapy scans so as to deliver 60 Gy to the thoracic disease in patients who had either a >20% volumetric increase or decrease in gross tumor volume (GTV) from chemotherapy. The prechemotherapy and postchemotherapy scans were analyzed to compare the percentage of lung volume receiving?20 Gy (V20), mean lung dose (MLD), and normal tissue complication probability (NTCP). Eight patients (32%) had a GTV reduction >20%, 2 (8%) had GTV increase >20%, and 15 (60%) had stable GTV. In the 8 responders, there was an absolute median GTV decrease of 88.1 cc (7.3 to 351.6 cc) or a 48% (20% to 62%) relative reduction in tumor burden. One had >20% tumor progression during chemotherapy, yet had an improvement in dosimetric parameters postchemotherapy. Among these 9 patients, the median decrease in V20, MLD, and NTCP was 2.6% (p<0.01), 2.1 Gy (p<0.01), and 5.6% (p<0.01), respectively. Less than one-third of patients with NSCLC obtain >20% volumetric tumor reduction from chemotherapy alone. Even with that amount of volumetric reduction, the 5% reduced risk of RP was only modest and did not convert previously ineligible patients to safely receive definitive thoracic RT.

Amin, Neha P., E-mail: npamin@gmail.com [Department of Radiation Oncology, Wayne State University and Karmanos Cancer Center, Detroit, MI (United States); Miften, Moyed; Thornton, Dale; Ryan, Nicole; Kavanagh, Brian; Gaspar, Laurie E [Department of Radiation Oncology, University of Colorado, Aurora, CO (United States)

2013-10-01T23:59:59.000Z

58

CONSTRAINTS ON ACCRETION DISK LIFETIMES  

E-Print Network [OSTI]

of stellar mass. #12; METHODOLOGY Constraining disk lifetimes means measuring infrared excesses and stellar ages and masses for large samples of young stellar objects. #12; Infrared excesses: #15; A combination of stellar irradiative and viscous heating in circumstellar disks produces ux excesses at micro

Hillenbrand, Lynne

59

Evidence That New Hypnotics Cause Cancer  

E-Print Network [OSTI]

medication use and risk of epithelial ovarian cancer.Cancer Epidemiol. Biomarkers Prev. , Hays, J. C. , Blazer,the likelihood of cancer causation is sufficiently strong

Kripke, Daniel F.

2008-01-01T23:59:59.000Z

60

Whole-Pelvic Nodal Radiation Therapy in the Context of Hypofractionation for High-Risk Prostate Cancer Patients: A Step Forward  

SciTech Connect (OSTI)

Given the low ?/? ratio of prostate cancer, prostate hypofractionation has been tested through numerous clinical studies. There is a growing body of literature suggesting that with high conformal radiation therapy and even with more sophisticated radiation techniques, such as high-dose-rate brachytherapy or image-guided intensity modulated radiation therapy, morbidity associated with shortening overall treatment time with higher doses per fraction remains low when compared with protracted conventional radiation therapy to the prostate only. In high-risk prostate cancer patients, there is accumulating evidence that either dose escalation to the prostate or hypofractionation may improve outcome. Nevertheless, selected patients who have a high risk of lymph node involvement may benefit from whole-pelvic radiation therapy (WPRT). Although combining WPRT with hypofractionated prostate radiation therapy is feasible, it remains investigational. By combining modern advances in radiation oncology (high-dose-rate prostate brachytherapy, intensity modulated radiation therapy with an improved image guidance for soft-tissue sparing), it is hypothesized that WPRT could take advantage of recent results from hypofractionation trials. Moreover, the results from hypofractionation trials raise questions as to whether hypofractionation to pelvic lymph nodes with a high risk of occult involvement might improve the outcomes in WPRT. Although investigational, this review discusses the challenging idea of WPRT in the context of hypofractionation for patients with high-risk prostate cancer.

Kaidar-Person, Orit [Division of Oncology, Rambam Health Care Campus, Haifa (Israel)] [Division of Oncology, Rambam Health Care Campus, Haifa (Israel); Roach, Mack [Department of Radiation Oncology, University of California, San Francisco, San Francisco, California (United States)] [Department of Radiation Oncology, University of California, San Francisco, San Francisco, California (United States); Créhange, Gilles, E-mail: gcrehange@cgfl.fr [Department of Radiation Oncology, Georges-François Leclerc Cancer Center, Dijon (France)] [Department of Radiation Oncology, Georges-François Leclerc Cancer Center, Dijon (France)

2013-07-15T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma  

SciTech Connect (OSTI)

In humans, hibernoma is a very rare, benign neoplasm of brown adipose tissue (BAT) that typically occurs at subcutaneous locations and is successfully treated by surgical excision. No single cause has been accepted to explain these very rare human tumors. In contrast, spontaneous hibernoma in rats is rare, often malignant, usually occurs in the thoracic or abdominal cavity, and metastases are common. In recent years, there has been an increased incidence of spontaneous hibernomas in rat carcinogenicity studies, but overall the occurrence remains relatively low and highly variable across studies. There have only been four reported examples of pharmaceutical-induced hibernoma in rat carcinogenicity studies. These include phentolamine, an alpha-adrenergic antagonist; varenicline, a nicotine partial agonist; tofacitinib, a Janus kinase (JAK) inhibitor; and hydromorphone, an opiod analgesic. Potential non-genotoxic mechanisms that may contribute to the pathogenesis of BAT activation/proliferation and/or subsequent hibernoma development in rats include: (1) physiological stimuli, (2) sympathetic stimulation, (3) peroxisome proliferator-activated receptor (PPAR) agonism, and/or (4) interference or inhibition of JAK/Signal Transducer and Activator of Transcription (JAK/STAT) signaling. The evaluation of an apparent increase of hibernoma in rats from 2-year carcinogenicity studies of novel pharmaceutical therapeutics and its relevance to human safety risk assessment is complex. One should consider: the genotoxicity of the test article, dose/exposure and safety margins, and pathophysiologic and morphologic differences and similarities of hibernoma between rats and humans. Hibernomas observed to date in carcinogenicity studies of pharmaceutical agents do not appear to be relevant for human risk at therapeutic dosages. - Highlights: • Highly variable incidence of spontaneous hibernoma in carcinogenicity studies • Recent increase in the spontaneous incidence of hibernomas in Sprague–Dawley rats • Pharmaceutical-related hibernoma has been observed in rats, but not in humans. • Pathophysiologic and morphologic differences of hibernoma between rats and 7 humans. • Hibernomas are unlikely to be relevant to human risk assessment.

Radi, Zaher, E-mail: zaher.radi@pfizer.com [Pfizer Worldwide Research and Development, Drug Safety R and D, 1 Burtt Rd., Andover, MA 01810 (United States); Bartholomew, Phillip, E-mail: phillip.m.bartholomew@pfizer.com [Pfizer Worldwide Research and Development, Drug Safety R and D, Eastern Point Road, Groton, CT 06340 (United States); Elwell, Michael, E-mail: michael.elwell@covance.com [Covance Laboratories, Chantilly, VA 20151 (United States); Vogel, W. Mark, E-mail: w.mark.vogel@pfizer.com [Pfizer Worldwide Research and Development, Drug Safety R and D, 1 Burtt Rd., Andover, MA 01810 (United States)

2013-12-15T23:59:59.000Z

62

Influence of egocentrism, future time perspective, and health locus of control on risk-takeing in adolescents diagosed with cancer and their siblings  

E-Print Network [OSTI]

WITH CANCER AND THEIR SIBLINGS A Thesis by NANCY ANN BAKER Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: Robert..., and Health Locus of Control on Risk-Taking in Adolescents Diagnosed with Cancer and Their Siblings. (December 1998) Nancy Ann Baker, B. S. , Sam Houston State University Chair of Advisory Committee: Dr. Robert W. Heffer, Jr. Professionals have noted...

Baker, Nancy Ann

1998-01-01T23:59:59.000Z

63

A Prospective Phase III Randomized Trial of Hypofractionation Versus Conventional Fractionation in Patients With High-Risk Prostate Cancer  

SciTech Connect (OSTI)

Purpose: To compare the toxicity and efficacy of hypofractionated (62 Gy/20 fractions/5 weeks, 4 fractions per week) vs. conventional fractionation radiotherapy (80 Gy/40 fractions/8 weeks) in patients with high-risk prostate cancer. Methods and Materials: From January 2003 to December 2007, 168 patients were randomized to receive either hypofractionated or conventional fractionated schedules of three-dimensional conformal radiotherapy to the prostate and seminal vesicles. All patients received a 9-month course of total androgen deprivation (TAD), and radiotherapy started 2 months thereafter. Results: The median (range) follow-up was 32 (8-66) and 35 (7-64) months in the hypofractionation and conventional fractionation arms, respectively. No difference was found for late toxicity between the two treatment groups, with 3-year Grade 2 rates of 17% and 16% for gastrointestinal and 14% and 11% for genitourinary in the hypofractionation and conventional fractionation groups, respectively. The 3-year freedom from biochemical failure (FFBF) rates were 87% and 79% in the hypofractionation and conventional fractionation groups, respectively (p = 0.035). The 3-year FFBF rates in patients at a very high risk (i.e., pretreatment prostate-specific antigen (iPSA) >20 ng/mL, Gleason score {>=}8, or T {>=}2c), were 88% and 76% (p = 0.014) in the former and latter arm, respectively. The multivariate Cox analysis confirmed fractionation, iPSA, and Gleason score as significant prognostic factors. Conclusions: Our findings suggest that late toxicity is equivalent between the two treatment groups and that the hypofractionated schedule used in this trial is superior to the conventional fractionation in terms of FFBF.

Arcangeli, Giorgio, E-mail: arcangeli@ifo.i [Department of Radiotherapy, Regina Elena National Cancer Institute, Rome (Italy); Saracino, Biancamaria; Gomellini, Sara; Petrongari, Maria Grazia; Arcangeli, Stefano [Department of Radiotherapy, Regina Elena National Cancer Institute, Rome (Italy)

2010-09-01T23:59:59.000Z

64

PSA Response to Neoadjuvant Androgen Deprivation Therapy Is a Strong Independent Predictor of Survival in High-Risk Prostate Cancer in the Dose-Escalated Radiation Therapy Era  

SciTech Connect (OSTI)

Purpose: The aim of the study was to evaluate the prognostic value of prostate-specific antigen (PSA) response to neoadjuvant androgen deprivation therapy (ADT) prior to dose-escalated radiation therapy (RT) and long-term ADT in high-risk prostate cancer. Methods and Materials: We reviewed the charts of all patients diagnosed with high-risk prostate cancer and treated with a combination of long-term ADT (median, 24 months) and dose-escalated (median, 75.6 Gy) RT between 1990 and 2007. The associations among patient, tumor, and treatment characteristics with biochemical response to neoadjuvant ADT and their effects on failure-free survival (FFS), time to distant metastasis (TDM), prostate cancer-specific mortality (PCSM) and overall survival (OS) were examined. Results: A total of 196 patients met criteria for inclusion. Median follow-up time for patients alive at last contact was 7.0 years (range, 0.5-18.1 years). Multivariate analysis identified the pre-RT PSA concentration (<0.5 vs {>=}0.5 ng/mL) as a significant independent predictor of FFS (P=.021), TDM (P=.009), PCSM (P=.039), and OS (P=.037). On multivariate analysis, pretreatment PSA (iPSA) and African-American race were significantly associated with failure to achieve a pre-RT PSA of <0.5 ng/mL. Conclusions: For high-risk prostate cancer patients treated with long-term ADT and dose-escalated RT, a pre-RT PSA level {>=}0.5 ng/mL after neoadjuvant ADT predicts for worse survival measures. Both elevated iPSA and African-American race are associated with increased risk of having a pre-RT PSA level {>=}0.5 ng/mL. These patients should be considered for clinical trials that test newer, more potent androgen-depleting therapies such as abiraterone and MDV3100 in combination with radiation.

McGuire, Sean E., E-mail: semcguir@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States); Lee, Andrew K. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cerne, Jasmina Z. [Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States)] [Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States); Munsell, Mark F. [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Levy, Lawrence B. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kudchadker, Rajat J. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Choi, Seungtaek L.; Nguyen, Quynh N.; Hoffman, Karen E.; Pugh, Thomas J.; Frank, Steven J. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Corn, Paul G.; Logothetis, Christopher J. [Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kuban, Deborah A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2013-01-01T23:59:59.000Z

65

Iodine-131 Releases from Radioactive Lanthanum Processing at the X-10 Site in Oak Ridge, Tennessee (1944-1956)- An Assessment of Quantities released, Off-Site Radiation Doses, and Potential Excess Risks of Thyroid Cancer- APPENDICES Appendices-Volume 1A  

SciTech Connect (OSTI)

This report consists of all the appendices for the report described below: In the early 1990s, concern about the Oak Ridge Reservation's past releases of contaminants to the environment prompted Tennessee's public health officials to pursue an in-depth study of potential off-site health effects at Oak Ridge. This study, the Oak Ridge dose reconstruction, was supported by an agreement between the U.S. Department of Energy (DOE) and the State of Tennessee, and was overseen by a 12-member panel appointed by Tennessee's Commissioner of Health. One of the major contaminants studied in the dose reconstruction was radioactive iodine, which was released to the air by X-10 (now called Oak Ridge National Laboratory) as it processed spent nuclear reactor fuel from 1944 through 1956. The process recovered radioactive lanthanum for use in weapons development. Iodine concentrates in the thyroid gland so health concerns include various diseases of the thyroid, such as thyroid cancer. The large report, ''Iodine-131 Releases from Radioactive Lanthanum Processing at the X-10 Site in Oak Ridge, Tennessee (1944-1956) - An Assessment of Quantities Released, Off-site Radiation Doses, and Potential Excess Risks of Thyroid Cancer,'' is in two volumes. Volume 1 is the main body of the report, and Volume 1A, which has the same title, consists of 22 supporting appendices. Together, these reports serve the following purposes: (1) describe the methodologies used to estimate the amount of iodine-131 (I-131) released; (2) evaluate I-131's pathway from air to vegetation to food to humans; (3) estimate doses received by human thyroids; (4) estimate excess risk of acquiring a thyroid cancer during ones lifetime; and (5) provide equations, examples of historical documents used, and tables of calculated values as appendices. Results indicate that females born in 1952 who consumed milk from a goat pastured a few miles east of X-10 received the highest doses from I-131 and would have had the highest risks of contracting thyroid cancer. Doses from cow's milk are considerably less. Detailed dose and risk estimates, and associated uncertainties, for other contaminants studied in the Oak Ridge dose reconstruction are presented in several other technical reports. One way to easily locate them in OSTI's Information Bridge is by searching the ''report number field'' for the number DOE/OR/21981*. Be sure to place the asterisk after the base number so your search can list the complete series of reports related to Oak Ridge Dose Reconstruction.

Apostoaei, A.I.; Burns, R.E.; Hoffman, F.O.; Ijaz, T.; Lewis, C.J.; Nair, S.K.; Widner, T.E.

1999-07-01T23:59:59.000Z

66

Lymphedema in Breast Cancer Survivors : : Risk Factors, Distress and Quality of Life, and Patient Compliance with a Physician Referral  

E-Print Network [OSTI]

function in breast cancer. Ann Behav Med. 2002;24(4):336–44.lymph nodes and lymphedema. Ann Surg Oncol. 2010;17:3278-86.of breast cancer survivors. Ann Surg Oncol. 2010;17(7):1847–

Dominick, Sally Ann

67

USING RISK-BASED CORRECTIVE ACTION (RBCA) TO ASSESS (THEORETICAL) CANCER DEATHS AVERTED COMPARED TO THE (REAL) COST OF ENVIRONMENTAL REMEDIATION  

SciTech Connect (OSTI)

In 1978, on the basis of existing health studies at the time, the Uranium Mill Tailings Remedial Action (UMTRA) Project legislation was proposed that would authorize remedial action at inactive uranium processing sites and vicinity properties. The cost of the program to the Federal Government was expected to be $180 million. With the completion of this project, approximately 1300 theoretical cancer deaths were prevented in the next 100 years at a cost of $1.45 billion, based on the Fiscal Year 1998 Federal UMTRA budget. The individual site costs ranged from $0.2 million up to $18 billion spent per theoretical cancer death averted over the next 100 years. Resources required to sustain remediation activities such as this are subject to reduction over time, and are originally based on conservative assumptions that tend to overestimate risks to the general public. This evaluation used a process incorporating risk-based corrective action (RBCA); a three-tiered, decision-making process tailoring corrective action activities according to site-specific conditions and risks. If RBCA had been applied at the start of the UMTRA Project, and using a criterion of >1 excess cancer death prevented as justification to remediate the site, only 50% of the existing sites would have been remediated, yielding a cost savings of $303.6 million to the Federal Government and affected States, which share 10% of the cost. This cost savings equates to 21% of the overall project budget. In addition, only 22% of the vicinity properties had structural contamination contributing to elevated interior gamma exposure and radon levels. Focusing only on these particular properties could have saved an additional $269.3 million, yielding a total savings of $573 million; 40% of the overall project budget. As operational experience is acquired, including greater understanding of the radiological and nonradiological risks, decisions should be based on the RBCA process, rather than relying on conservative assumptions that tend to overestimate risks to the general public.

Miller, M. L.; Hylko, J. M.

2002-02-25T23:59:59.000Z

68

E-Print Network 3.0 - advanced cancer detection Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Powered by Explorit Topic List Advanced Search Sample search results for: advanced cancer detection Page: << < 1 2 3 4 5 > >> 1 The Cancer Risk Clinic Cancer Risk Clinical...

69

Influence of Androgen Deprivation Therapy on All-Cause Mortality in Men With High-Risk Prostate Cancer and a History of Congestive Heart Failure or Myocardial Infarction  

SciTech Connect (OSTI)

Purpose: It is unknown whether the excess risk of all-cause mortality (ACM) observed when androgen deprivation therapy (ADT) is added to radiation for men with prostate cancer and a history of congestive heart failure (CHF) or myocardial infarction (MI) also applies to those with high-risk disease. Methods and Materials: Of 14,594 men with cT1c-T3aN0M0 prostate cancer treated with brachytherapy-based radiation from 1991 through 2006, 1,378 (9.4%) with a history of CHF or MI comprised the study cohort. Of these, 22.6% received supplemental external beam radiation, and 42.9% received a median of 4 months of neoadjuvant ADT. Median age was 71.8 years. Median follow-up was 4.3 years. Cox multivariable analysis tested for an association between ADT use and ACM within risk groups, after adjusting for treatment factors, prognostic factors, and propensity score for ADT. Results: ADT was associated with significantly increased ACM (adjusted hazard ratio [AHR] = 1.76; 95% confidence interval [CI], 1.32-2.34; p = 0.0001), with 5-year estimates of 22.71% with ADT and 11.62% without ADT. The impact of ADT on ACM by risk group was as follows: high-risk AHR = 2.57; 95% CI, 1.17-5.67; p = 0.019; intermediate-risk AHR = 1.75; 95% CI, 1.13-2.73; p = 0.012; low-risk AHR = 1.52; 95% CI, 0.96-2.43; p = 0.075). Conclusions: Among patients with a history of CHF or MI treated with brachytherapy-based radiation, ADT was associated with increased all-cause mortality, even for patients with high-risk disease. Although ADT has been shown in Phase III studies to improve overall survival in high-risk disease, the small subgroup of high-risk patients with a history of CHF or MI, who represented about 9% of the patients, may be harmed by ADT.

Nguyen, Paul L., E-mail: pnguyen@LROC.harvard.edu [Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States); Chen, Ming-Hui [Department of Statistics, University of Connecticut, Storrs, CT (United States); Beckman, Joshua A. [Department of Cardiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States); Beard, Clair J.; Martin, Neil E. [Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States); Choueiri, Toni K. [Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA (United States); Hu, Jim C. [Division of Urologic Surgery, Brigham and Women's/Faulkner Hospital, Harvard Medical School, Boston, MA (United States); Hoffman, Karen E. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Dosoretz, Daniel E. [21st Century Oncology, Fort Myers, FL (United States); Moran, Brian J. [Chicago Prostate Center, Westmont, IL (United States); Salenius, Sharon A. [21st Century Oncology, Fort Myers, FL (United States); Braccioforte, Michelle H. [Chicago Prostate Center, Westmont, IL (United States); Kantoff, Philip W. [Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA (United States); D'Amico, Anthony V. [Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States); Ennis, Ronald D. [Department of Radiation Oncology, St. Luke's-Roosevelt and Beth Israel Hospitals, Continuum Cancer Centers of New York, Albert Einstein College of Medicine, New York, NY (Israel)

2012-03-15T23:59:59.000Z

70

Retrospective Evaluation Reveals That Long-term Androgen Deprivation Therapy Improves Cause-Specific and Overall Survival in the Setting of Dose-Escalated Radiation for High-Risk Prostate Cancer  

SciTech Connect (OSTI)

Purpose: To evaluate the role of androgen deprivation therapy (ADT) and duration for high-risk prostate cancer patients treated with dose-escalated radiation therapy (RT). Methods and Materials: A retrospective analysis of high-risk prostate cancer patients treated with dose-escalated RT (minimum 75 Gy) with or without ADT was performed. The relationship between ADT use and duration with biochemical failure (BF), metastatic failure (MF), prostate cancer-specific mortality (PCSM), non-prostate cancer death (NPCD), and overall survival (OS) was assessed as a function of pretreatment characteristics, comorbid medical illness, and treatment using Fine and Gray's cumulative incidence methodology. Results: The median follow-up time was 64 months. In men with National Comprehensive Cancer Network defined high-risk prostate cancer treated with dose-escalated RT, on univariate analysis, both metastasis (P<.0001; hazard ratio 0.34; 95% confidence interval 0.18-0.67; cumulative incidence at 60 months 13% vs 35%) and PCSM (P=.015; hazard ratio 0.41; 95% confidence interval 0.2-1.0; cumulative incidence at 60 months 6% vs 11%) were improved with the use of ADT. On multivariate analysis for all high-risk patients, Gleason score was the strongest negative prognostic factor, and long-term ADT (LTAD) improved MF (P=.002), PCSM (P=.034), and OS (P=.001). In men with prostate cancer and Gleason scores 8 to 10, on multivariate analysis after adjustment for other risk features, there was a duration-dependent improvement in BF, metastasis, PCSM, and OS, all favoring LTAD in comparison with STAD or RT alone. Conclusion: For men with high-risk prostate cancer treated with dose-escalated EBRT, this retrospective study suggests that the combination of LTAD and RT provided a significant improvement in clinical outcome, which was especially true for those with Gleason scores of 8 to 10.

Feng, Felix Y., E-mail: ffeng@med.umich.edu [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Department of Radiation Oncology, Veterans Affairs Medical Center, Ann Arbor, Michigan (United States); Blas, Kevin; Olson, Karin; Stenmark, Matthew [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Sandler, Howard [Cedars Sinai Medical Center, Los Angeles, California (United States)] [Cedars Sinai Medical Center, Los Angeles, California (United States); Hamstra, Daniel A. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)

2013-05-01T23:59:59.000Z

71

Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the EPIC-Norfolk study  

E-Print Network [OSTI]

of breast cancer, but only a limited range of phytoestrogens has been examined in prospective cohort studies. Methods Serum and urine samples from 237 incident breast cancer cases and 952 control individuals (aged 45 to 75 years) in the European Prospective...

Ward, Heather A; Chapelais, Gaelle; Kuhnle, Gunter G C; Luben, Robert; Khaw, Kay-Tee; Bingham, Sheila

2008-04-17T23:59:59.000Z

72

Combination External Beam Radiation and Brachytherapy Boost With Androgen Suppression for Treatment of Intermediate-Risk Prostate Cancer: An Initial Report of CALGB 99809  

SciTech Connect (OSTI)

Purpose: Transperineal prostate brachytherapy (TPPB) can be used with external beam radiation therapy (EBRT) to provide a high-dose conformal boost to the prostate. The results of a multicenter Phase II trial assessing safety of combination of EBRT and TPPB boost with androgen suppression (AST) in treatment of intermediate-risk prostate cancer are present here. Materials and Methods: Patients had intermediate-risk prostate cancer. Six months of AST was administered. EBRT to the prostate and seminal vesicles was administered to 45Gy followed by TPPB using either {sup 125}I or {sup 103}Pd to deliver an additional 100Gy or 90Gy. Toxicity was graded using the National Cancer Institute CTC version 2 and the Radiation Therapy Oncology Group late radiation morbidity scoring systems. Results: Sixty-three patients were enrolled. Median follow-up was 38 months. Side effects of AST including sexual dysfunction and vasomotor symptoms were commonly observed. Apart from erectile dysfunction, short-term Grade 2 and 3 toxicity was noted in 21% and 7%, primarily genitourinary related. Long-term Grade 2 and 3 toxicities were noted in 13% and 3%. Two patients had Grade 3 dysuria that resolved with longer follow-up. The most common Grade 2 long-term toxicity was urinary frequency (5%). No biochemical or clinical evidence of progression was noted for the entire cohort. Conclusions: In a cooperative group setting, combination EBRT and TPPB boost with 6 months of AST was generally well tolerated with expected genitourinary and gastrointestinal toxicities. Further follow-up will be required to fully assess long-term toxicity and cancer control.

Hurwitz, Mark D. [Dana-Farber/Brigham and Women's Cancer Center, Boston, MA (United States)], E-mail: mhurwitz@lroc.harvard.edu; Halabi, Susan [Harvard Medical School, Boston, MA (United States); Ou, San-San [CALGB Statistical Center, Duke University Medical Center, Durham, NC (United States); McGinnis, Lamar S. [Southeast Cancer Control Consortium, Winston Salem, NC (United States); Keuttel, Michael R. [Roswell Park Cancer Institute, Buffalo, NY (United States); DiBiase, Steven J. [University of Maryland Medical Center, Baltimore, MD (United States); Small, Eric J. [University of California at San Francisco Comprehensive Cancer Center, San Francisco, CA (United States)

2008-11-01T23:59:59.000Z

73

Atmospheric Lifetime of Fossil Fuel Carbon Dioxide  

E-Print Network [OSTI]

Atmospheric Lifetime of Fossil Fuel Carbon Dioxide David Archer,1 Michael Eby,2 Victor Brovkin,3 released from combustion of fossil fuels equilibrates among the various carbon reservoirs of the atmosphere literature on the atmospheric lifetime of fossil fuel CO2 and its impact on climate, and we present initial

Scherer, Norbert F.

74

Is Biological Subtype Prognostic of Locoregional Recurrence Risk in Women With pT1-2N0 Breast Cancer Treated With Mastectomy?  

SciTech Connect (OSTI)

Purpose: To examine locoregional and distant recurrence (LRR and DR) in women with pT1-2N0 breast cancer according to approximated subtype and clinicopathologic characteristics. Methods and Materials: Two independent datasets were pooled and analyzed. The study participants were 1994 patients with pT1-2N0M0 breast cancer, treated with mastectomy without radiation therapy. The patients were classified into 1 of 5 subtypes: luminal A (ER+ or PR+/HER 2?/grade 1-2, n=1202); luminal B (ER+ or PR+/HER 2?/grade 3, n=294); luminal HER 2 (ER+ or PR+/HER 2+, n=221); HER 2 (ER?/PR?/HER 2+, n=105) and triple-negative breast cancer (TNBC) (ER?/PR?/HER 2?, n=172). Results: The median follow-up time was 4.3 years. The 5-year Kaplan-Meier (KM) LRR were 1.8% in luminal A, 3.1% in luminal B, 1.7% in luminal HER 2, 1.9% in HER 2, and 1.9% in TNBC cohorts (P=.81). The 5-year KM DR was highest among women with TNBC: 1.8% in luminal A, 5.0% in luminal B, 2.4% in luminal HER 2, 1.1% in HER 2, and 9.6% in TNBC cohorts (P<.001). Among 172 women with TNBC, the 5-year KM LRR were 1.3% with clear margins versus 12.5% with close or positive margins (P=.04). On multivariable analysis, factors that conferred higher LRR risk were tumors >2 cm, lobular histology, and close/positive surgical margins. Conclusions: The 5-year risk of LRR in our pT1-2N0 cohort treated with mastectomy was generally low, with no significant differences observed between approximated subtypes. Among the subtypes, TNBC conferred the highest risk of DR and an elevated risk of LRR in the presence of positive or close margins. Our data suggest that although subtype alone cannot be used as the sole criterion to offer postmastectomy radiation therapy, it may reasonably be considered in conjunction with other clinicopathologic factors including tumor size, histology, and margin status. Larger cohorts and longer follow-up times are needed to define which women with node-negative disease have high postmastectomy LRR risks in contemporary practice.

Truong, Pauline T., E-mail: ptruong@bccancer.bc.ca [Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, Victoria, BC (Canada); Breast Cancer Outcomes Unit, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, Victoria, BC (Canada); Sadek, Betro T. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Lesperance, Maria F. [Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, Victoria, BC (Canada); Alexander, Cheryl S. [Breast Cancer Outcomes Unit, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, Victoria, BC (Canada); Shenouda, Mina; Raad, Rita Abi; Taghian, Alphonse G. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)

2014-01-01T23:59:59.000Z

75

10-Year Survival and Quality of Life in Patients With High-Risk {sub P}N{sub 0} Prostate Cancer Following Definitive Radiotherapy  

SciTech Connect (OSTI)

Purpose: To evaluate long-term overall survival (OS), cancer-specific survival (CSS), clinical progression-free survival (cPFS), and health-related quality of life (HRQoL) following definitive radiotherapy (RT) given to T{sub 1-4p}N{sub 0}M{sub 0} prostate cancer patients provided by a single institution between 1989 and 1996. Methods and Materials: We assessed outcome among 203 patients who had completed three-dimensional conformal RT (66 Gy) without hormone treatment and in whom staging by lymphadenectomy had been performed. OS was compared with an age-matched control group from the general population. A cross-sectional, self-report survey of HRQoL was performed among surviving patients. Results: Median observation time was 10 years (range, 1-16 years). Eighty-one percent had high-risk tumors defined as T{sub 3-4} or Gleason score (GS) {>=}7B (4+3). Among these, 10-year OS, CSS, and cPFS rates were 52%, 66%, and 39%, respectively. The corresponding fractions in low-risk patients (T{sub 1-2} and GS {<=}7A [3+4]) were 79%, 95%, and 73%, respectively. Both CSS and cPFS were predicted by GS and T-classification; OS was associated with GS only. High-risk, but not low-risk, patients had reduced OS compared with the general population (p < 0.0005). When pelvis-related side effects were included in multivariate analyzes together with physical function and pain, sexual, urinary, and bowel function were not independently associated with self-reported global quality of life. Conclusions: Despite surgically proven {sub p}N{sub 0}, RT with dosage <70 Gy as monotherapy does not give satisfactory CSS rates after 10 years in patients with T{sub 3-4} or GS {>=}7B.

Berg, Arne [Faculty of Medicine, University of Oslo, Oslo (Norway)], E-mail: arne.berg@radiumhospitalet.no; Lilleby, Wolfgang [Department of Oncology, Rikshospitalet-Radiumhospitalet Medical Center, Oslo (Norway); Bruland, Oyvind Sverre; Fossa, Sophie Dorothea [Faculty of Medicine, University of Oslo, Oslo (Norway); Department of Oncology, Rikshospitalet-Radiumhospitalet Medical Center, Oslo (Norway)

2007-11-15T23:59:59.000Z

76

Functional Promoter Variant rs2868371 of HSPB1 Is Associated With Risk of Radiation Pneumonitis After Chemoradiation for Non-Small Cell Lung Cancer  

SciTech Connect (OSTI)

Purpose: To date, no biomarkers have been found to predict, before treatment, which patients will develop radiation pneumonitis (RP), a potentially fatal toxicity, after chemoradiation for lung cancer. We investigated potential associations between single nucleotide polymorphisms (SNPs) in HSPB1 and risk of RP after chemoradiation for non-small cell lung cancer (NSCLC). Methods and Materials: Subjects were patients with NSCLC treated with chemoradiation at 1 institution. The training data set comprised 146 patients treated from 1999 to July 2004; the validation data set was 125 patients treated from August 2004 to March 2010. We genotyped 2 functional SNPs of HSPB1 (rs2868370 and rs2868371) from all patients. We used Kaplan-Meier analysis to assess the risk of grade ?2 or ?3 RP in both data sets and a parametric log-logistic survival model to evaluate the association of HSPB1 genotypes with that risk. Results: Grade ?3 RP was experienced by 13% of those with CG/GG and 29% of those with CC genotype of HSPB1 rs2868371 in the training data set (P=.028); corresponding rates in the validation data set were 2% CG/GG and 14% CC (P=.02). Univariate and multivariate analysis confirmed the association of CC of HSPB1 rs2868371 with higher risk of grade ?3 RP than CG/GG after adjustment for sex, age, performance status, and lung mean dose. This association was validated both in the validation data set and with Harrell's C statistic. Conclusions: The CC genotype of HSPB1 rs2868371 was associated with severe RP after chemoradiation for NSCLC.

Pang, Qingsong [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States) [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Department of Radiation Oncology and Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin (China); Wei, Qingyi [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States); Xu, Ting [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Yuan, Xianglin [Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan (China)] [Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan (China); Lopez Guerra, Jose Luis [Department of Medicine, Universitat Autònoma de Barcelona (Spain)] [Department of Medicine, Universitat Autònoma de Barcelona (Spain); Levy, Lawrence B. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Liu, Zhensheng [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States); Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Zhuang, Yan [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States); Wang, Li-E. [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States); Mohan, Radhe [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States); Komaki, Ritsuko [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)

2013-04-01T23:59:59.000Z

77

Common variants in the ATM, BRCA1, BRCA2, CHEK2 & TP53 cancer susceptibility genes are unlikely to increase breast cancer risk  

E-Print Network [OSTI]

Abstract Introduction Certain rare, familial mutations in the ATM, BRCA1, BRCA2, CHEK2 or TP53 genes increase susceptibility to breast cancer but it has not, until now, been clear whether common polymorphic variants in the same genes also increase...

Baynes, Caroline; Healey, Catherine S; Pooley, Karen A; Scollen, Serena A; Luben, Robert; Thompson, Deborah J; Pharoah, Paul D P; Easton, Douglas F; Ponder, Bruce A J; Dunning, Alison M

2007-04-11T23:59:59.000Z

78

Nervous system cancer : analysis of historical mortality rates in the United States and Japan indicate sudden increases in environmental risk  

E-Print Network [OSTI]

Nervous System cancer age-specific mortality rates began being recorded for European and Non-European Americans in 1930 and for Japanese in 1952. All ethnic groups show significant historical increases in mortality rates. ...

Alhassani, Ali K

2008-01-01T23:59:59.000Z

79

Twice-Weekly Hypofractionated Intensity-Modulated Radiotherapy for Localized Prostate Cancer With Low-Risk Nodal Involvement: Toxicity and Outcome From a Dose Escalation Pilot Study  

SciTech Connect (OSTI)

Purpose: To evaluate the toxicity and preliminary outcome of patients with localized prostate cancer treated with twice-weekly hypofractionated intensity-modulated radiotherapy (IMRT). Methods and Materials: Between 2003 and 2006, 82 prostate cancer patients with a nodal involvement risk {<=}20% (Roach index) have been treated to the prostate with or without seminal vesicles with 56 Gy (4 Gy/fraction twice weekly) and an overall treatment time of 6.5 weeks. Acute and late genitourinary (GU) and gastrointestinal (GI) toxicities were scored according to the Radiation Therapy Oncology Group (RTOG) grading system. Median follow-up was 48 months (range, 9-67 months). Results: All patients completed the treatment without interruptions. No patient presented with Grade {>=}3 acute GU or GI toxicity. Of the patients, 4% presented with Grade 2 GU or GI persistent acute toxicity 6 weeks after treatment completion. The estimated 4-year probability of Grade {>=}2 late GU and GI toxicity-free survival were 94.2% {+-} 2.9% and 96.1% {+-} 2.2%, respectively. One patient presented with Grade 3 GI and another patient with Grade 4 GU late toxicity, which were transitory in both cases. The 4-year actuarial biochemical relapse-free survival was 91.3% {+-} 5.9%, 76.4% {+-} 8.8%, and 77.5% {+-} 8.9% for low-, intermediate-, and high-risk groups, respectively. Conclusions: In patients with localized prostate cancer, acute and late toxicity were minimal after dose-escalation administering twice-weekly 4 Gy to a total dose of 56 Gy, with IMRT. Further prospective trials are warranted to further assess the best fractionation schemes for these patients.

Zilli, Thomas, E-mail: thomaszilli@inwind.it [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Jorcano, Sandra [Servei de Radio-oncologia, Institut Oncologic Teknon, Barcelona (Spain); Rouzaud, Michel; Dipasquale, Giovanna; Nouet, Philippe [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Toscas, Jose Ignacio [Servei de Radio-oncologia, Institut Oncologic Teknon, Barcelona (Spain); Casanova, Nathalie; Wang, Hui [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Escude, Lluis; Molla, Meritxell; Linero, Dolors [Servei de Radio-oncologia, Institut Oncologic Teknon, Barcelona (Spain); Weber, Damien C. [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Miralbell, Raymond [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Servei de Radio-oncologia, Institut Oncologic Teknon, Barcelona (Spain)

2011-10-01T23:59:59.000Z

80

Models for Battery Reliability and Lifetime  

SciTech Connect (OSTI)

Models describing battery degradation physics are needed to more accurately understand how battery usage and next-generation battery designs can be optimized for performance and lifetime. Such lifetime models may also reduce the cost of battery aging experiments and shorten the time required to validate battery lifetime. Models for chemical degradation and mechanical stress are reviewed. Experimental analysis of aging data from a commercial iron-phosphate lithium-ion (Li-ion) cell elucidates the relative importance of several mechanical stress-induced degradation mechanisms.

Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G. H.; Neubauer, J.; Pesaran, A.

2014-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
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81

Eur J Cancer. Author manuscript Social inequalities in cancer incidence and cancer survival: Lessons from  

E-Print Network [OSTI]

Eur J Cancer. Author manuscript Page /1 5 Social inequalities in cancer incidence and cancer ( ). With regards to cancer risk, a first comprehensive review of socioeconomic inequalities was1 published by IARC in 1997 ( ). This review covered inequalities in cancer mortality, incidence and survival and discussed

Paris-Sud XI, Université de

82

Efficiency and lifetime of carbon foils  

SciTech Connect (OSTI)

Charge-exchange injection by means of carbon foils is a widely used method in accelerators. This paper discusses two critical issues concerning the use of carbon foils: efficiency and lifetime. An energy scaling of stripping efficiency was suggested and compared with measurements. Several factors that determine the foil lifetime--energy deposition, heating, stress and buckling--were studied by using the simulation codes MARS and ANSYS.

Chou, W.; /Fermilab; Kostin, M.; /Michigan State U., NSCL; Tang, Z.; /Fermilab

2006-11-01T23:59:59.000Z

83

Diffusion Simulation and Lifetime Calculation at RHIC  

SciTech Connect (OSTI)

The beam lifetime is an important parameter for any storage ring. For protons in RHIC it is dominated by the non-linear nature of the head-on collisions that causes the particles to diffuse outside the stable area in phase space. In this report we show results from diffusion simulation and lifetime calculation for the 2006 and 2008 polarized proton runs in RHIC.

Abreu,N.P.; Fischer, W.; Luo, Y.; Robert-Demolaize, G.

2009-01-02T23:59:59.000Z

84

EPA`s risk assessment guidelines: Overview  

SciTech Connect (OSTI)

The US Environmental Protection Agency (EPA) risk assessment guidelines for cancer, quantification, and exposure issues are discussed.

Patton, D.E. [Environmental Protection Agency, Washington, DC (United States)

1990-12-31T23:59:59.000Z

85

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation  

E-Print Network [OSTI]

Tchatchou52, Elinor J. Sawyer57, Ian Tomlinson58, Michael J. Kerin59, Nicola Miller59, Australian Ovarian Cancer Management Group2,60 , Christopher A. Haiman61, Brian E. Henderson61, Fredrick Schumacher61, Loic Le Marchand62, Annika Lindblom63, Sara...

Ghoussaini, Maya; Edwards, Stacey L.; Michailidou, Kyriaki; Nord, Silje; Cowper-Sal•lari, Richard; Desai, Kinjal; Kar, Siddhartha; Hillman, Kristine M.; Kaufmann, Susanne; Glubb, Dylan M.; Beesley, Jonathan; Dennis, Joe; Bolla, Manjeet K.; Wang, Qin; Dicks, Ed; Guo, Qi; Schmidt, Marjanka K.; Shah, Mitul; Luben, Robert; Brown, Judith; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Daniel, Klevebring; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Lambrechts, Diether; Thienpont, Bernard; Neven, Patrick; Wildiers, Hans; Broeks, Annegien; Van’t Veer, Laura J.; Rutgers, Emiel J. Th.; Couch, Fergus J.; Olson, Janet E.; Hallberg, Emily; Vachon, Celine; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Peto, Julian; dos-Santos-Silva, Isabel; Gibson, Lorna; Nevanlinna, Heli; Muranen, Taru A.; Aittomäki, Kristiina; Blomqvist, Carl; Hall, Per; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Kang, Daehee; Choi, Ji-Yeob; Park, Sue K.; Noh, Dong-Young; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Guénel, Pascal; Truong, Thérèse; Menegaux, Florence; Sanchez, Marie; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Wu, Anna H.; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O.; Benitez, Javier; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Menéndez, Primitiva; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Qiuyin; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Tchatchou, Sandrine; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Australian Ovarian Cancer Management Group; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Lindblom, Annika; Margolin, Sara; Teo, Soo Hwang; Yip, Cheng Har; Lee, Daphne S. C.; Wong, Tien Y.; Hooning, Maartje J.; Martens, John W. M.; Collée, J. Margriet; van Deurzen, Carolien H. M.; Hopper, John L.; Southey, Melissa C.; Tsimiklis, Helen; Kapuscinski, Miroslav K.; Shen, Chen-Yang; Wu, Pei-Ei; Yu, Jyh-Cherng; Chen, Shou-Tung; Grenaker Alnæs, Grethe; Borresen-Dale, Anne-Lise; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Hartman, Mikael; Miao, Hui; Syed Buhari, Shaik Ahmad Bin; Teo, Yik Ying; Fasching, Peter A.; Haeberle, Lothar; Ekici, Arif B.; Beckmann, Matthias W.; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Schoemaker, Minouk J.; García-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Brauch, Hiltrud; Brüning, Thomas; Koto, Yon-Dschun; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Volorio, Sara; Dörk, Thilo; Bogdanova, Natalia V.; Helbig, Sonja; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Devilee, Peter; Tollenaar, Robert A. E. M.; Seynaeve, Caroline; Van Asperen, Christi J.; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Slager, Susan; Toland, Amanda E.; Ambrosone, Christine B.; Yannoukakos, Drakoulis; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Hamann, Ute; Torres, Diana; Zheng, Wei; Long, Jirong; Anton-Culver, Hoda; Neuhausen, Susan L.; Luccarini, Craig; Baynes, Caroline; Ahmed, Shahana; Maranian, Mel; Healey, Catherine S.; González-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Álvarez, Nuria; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; de Santiago, Ines; Carroll, Jason; Caldas, Carlos; Brown, Melissa A.; Lupien, Mathieu; Kristensen, Vessela N.; Pharoah, Paul D.P.; Chenevix-Trench, Georgia; French, Juliet D.; Easton, Douglas F.; Dunning, Alison M.

2014-09-23T23:59:59.000Z

86

Determination of the historical changes in primary and secondary risk factors for cancer using U.S. public health records  

E-Print Network [OSTI]

Overall cancer mortality rates have risen from about 4% of all deaths in the early 20th century to about 25% of all deaths by the end of the century in the United States. To assess any potential hypotheses for this increase ...

Herrero Jimenez, Pablo, 1972-

2001-01-01T23:59:59.000Z

87

Lack of benefit of pelvic radiation in prostate cancer patients with a high risk of positive pelvic lymph nodes treated with high-dose radiation  

SciTech Connect (OSTI)

Purpose: The use of pelvic radiation for patients with a high risk of lymph node (LN) metastasis (>15%) remains controversial. We reviewed the data at three institutions treating patients with a combination of external-beam radiation therapy and high-dose-rate brachytherapy to address the prognostic implications of the use of the Roach formula and the benefit of pelvic treatment. Methods and Materials: From 1986 to 2003, 1,491 patients were treated with external-beam radiation therapy and high-dose-rate brachytherapy. The Roach formula [2/3 prostate-specific antigen + (Gleason score -6) x 10] could be calculated for 1,357 patients. Group I consisted of patients having a risk of positive LN {<=}15% (n = 761), Group II had a risk >15% and {<=}30% (n = 422), and Group III had a risk of LN disease >30% (n 174). A >15% risk of having positive LN was found in 596 patients and was used to determine the benefit of pelvic radiation. The pelvis was treated at two of the cancer centers (n = 312), whereas at the third center (n = 284) radiation therapy was delivered to the prostate and seminal vesicles alone. Average biologic effective dose was {>=}100 Gy ({alpha}{beta} = 1.2). Biochemical failure was as per the American Society for Therapeutic Radiology and Oncology definition. Statistics included the log-rank test as well as Cox univariate and multivariate analysis. Results: For all 596 patients with a positive LN risk >15%, median follow-up was 4.3 years, with a mean of 4.8 years. For all cases, median follow-up was 4 years and mean follow-up was 4.4 years. Five-year results for the three groups based on their risk of positive LN were significantly different in terms of biochemical failure (p < 0.001), clinical control (p < 0.001), disease-free survival excluding biochemical failure (p < 0.001), cause-specific survival (p < 0.001), and overall survival (p < 0.001). For all patients with a risk of positive LN >15% (n 596), Group II (>15-30% risk), or Group III (>30% risk), no benefit was seen in the 5-year rates of clinical failure, cause-specific survival, or overall survival with pelvic radiation. In the Cox multivariate analysis for cause-specific survival, Gleason score (p = 0.009, hazard ratio [HR] 3.1), T stage (p = 0.03, HR 1.8), and year of treatment (p = 0.05, HR 1.1) were significant. A log-rank test for cause-specific survival for all patients (n = 577) by the use of pelvic radiation was not significant (p = 0.99) accounting for high-dose-rate brachytherapy dose, neoadjuvant hormones, Gleason score, prostate-specific antigen, T stage, and year of treatment as covariates. Conclusions: The use of the Roach formula to stratify patients for clinical and biochemical outcomes is excellent. Pelvic radiation added to high prostate radiation doses did not show a clinical benefit for patients at a high risk of pelvic LN disease (>15%) selected using the Roach formula.

Vargas, Carlos Enrique [William Beaumont Hospital, Royal Oak, MI (United States); Galalae, Razavan [Kiel University Hospital, Kiel (Germany); Demanes, Jeffrey [California Endocuritherapy Cancer Center, Oakland, CA (United States); Harsolia, Asif [William Beaumont Hospital, Royal Oak, MI (United States); Meldolesi, Elisa [William Beaumont Hospital, Royal Oak, MI (United States); Nuernberg, Nils [Municipal Hospital Kiel, Kiel (Germany); Schour, Lionel [California Endocuritherapy Cancer Center, Oakland, CA (United States); Martinez, Alvaro [William Beaumont Hospital, Royal Oak, MI (United States)]. E-mail: amartinez@beaumont.edu

2005-12-01T23:59:59.000Z

88

Factors Affecting the Risk of Brain Metastasis in Small Cell Lung Cancer With Surgery: Is Prophylactic Cranial Irradiation Necessary for Stage I-III Disease?  

SciTech Connect (OSTI)

Purpose: The use of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) with surgical resection has not been fully identified. This study undertook to assess the factors affecting the risk of brain metastases in patients with stage I-III SCLC after surgical resection. The implications of PCI treatment for these patients are discussed. Methods and Materials: One hundred twenty-six patients treated with surgical resection for stage I-III SCLC from January 1998-December 2009 were retrospectively analyzed to elucidate the risk factors of brain metastases. Log-rank test and Cox regression model were used to determine the risk factors of brain metastases. Results: The median survival time for this patient population was 34 months, and the 5-year overall survival rate was 34.9%. For the whole group, 23.0% (29/126) of the patients had evidence of metastases to brain. Pathologic stage not only correlated with overall survival but also significantly affected the risk of brain metastases. The 5-year survival rates for patients with pathologic stages I, II, and III were 54.8%, 35.6%, and 14.1%, respectively (P=.001). The frequency of brain metastases in patients with pathologic stages I, II, and III were 6.25% (2/32), 28.2% (11/39), and 29.1% (16/55) (P=.026), respectively. A significant difference in brain metastases between patients with complete resection and incomplete resection was also observed (20.5% vs 42.9%, P=.028). The frequency of brain metastases was not found to be correlated with age, sex, pathologic type, induction chemotherapy, adjuvant chemotherapy, or adjuvant radiation therapy. Conclusions: Stage I SCLC patients with complete resection had a low incidence of brain metastases and a favorable survival rate. Stage II-III disease had a higher incidence of brain metastases. Thus, PCI might have a role for stage II-III disease but not for stage I disease.

Gong Linlin; Wang, Q.I.; Zhao Lujun; Yuan Zhiyong; Li Ruijian [Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, and Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin (China)] [Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, and Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin (China); Wang Ping, E-mail: Doctorwang66@yahoo.cn [Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, and Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin (China)

2013-01-01T23:59:59.000Z

89

E-Print Network 3.0 - advanced colon cancer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: advanced colon cancer Page: << < 1 2 3 4 5 > >> 1 The Cancer Risk Clinic Cancer Risk...

90

Toxicity Assessment of Pelvic Intensity-Modulated Radiotherapy With Hypofractionated Simultaneous Integrated Boost to Prostate for Intermediate- and High-Risk Prostate Cancer  

SciTech Connect (OSTI)

Purpose: To evaluate the toxicity of pelvic intensity-modulated radiotherapy (IMRT) with hypofractionated simultaneous integrated boost (SIB) to the prostate for patients with intermediate- to high-risk prostate cancer. Methods and Materials: A retrospective toxicity analysis was performed in 30 consecutive patients treated definitively with pelvic SIB-IMRT, all of whom also received androgen suppression. The IMRT plans were designed to deliver 70 Gy in 28 fractions (2.5 Gy/fraction) to the prostate while simultaneously delivering 50.4 Gy in 28 fractions (1.8 Gy/fraction) to the pelvic lymph nodes. The National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0, was used to score toxicity. Results: The most common acute Grade 2 events were cystitis (36.7%) and urinary frequency/urgency (26.7%). At a median follow-up of 24 months, late toxicity exceeding Grade 2 in severity was uncommon, with two Grade 3 events and one Grade 4 event. Grade 2 or greater acute bowel toxicity was associated with signficantly greater bowel volume receiving {>=}25 Gy (p = .04); Grade 2 or greater late bowel toxicity was associated with a higher bowel maximal dose (p = .04) and volume receiving {>=}50 Gy (p = .02). Acute or late bladder and rectal toxicity did not correlate with any of the dosimetric parameters examined. Conclusion: Pelvic IMRT with SIB to the prostate was well tolerated in this series, with low rates of Grade 3 or greater acute and late toxicity. SIB-IMRT combines pelvic radiotherapy and hypofractionation to the primary site and offers an accelerated approach to treating intermediate- to high-risk disease. Additional follow-up is necessary to fully define the long-term toxicity after hypofractionated, whole pelvic treatment combined with androgen suppression.

McCammon, Robert; Rusthoven, Kyle E.; Kavanagh, Brian; Newell, Sherri B.S.; Newman, Francis M.S. [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States); Raben, David [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States)], E-mail: david.raben@uchsc.edu

2009-10-01T23:59:59.000Z

91

Supercontinuum Stimulated Emission Depletion Fluorescence Lifetime Imaging  

SciTech Connect (OSTI)

Supercontinuum (SC) stimulated emission depletion (STED) fluorescence lifetime imaging is demonstrated by using time-correlated single-photon counting (TCSPC) detection. The spatial resolution of the developed STED instrument was measured by imaging monodispersed 40-nm fluorescent beads and then determining their fwhm, and was 36 ± 9 and 40 ± 10 nm in the X and Y coordinates, respectively. The same beads measured by confocal microscopy were 450 ± 50 and 430 ± 30 nm, which is larger than the diffraction limit of light due to underfilling the microscope objective. Underfilling the objective and time gating the signal were necessary to achieve the stated STED spatial resolution. The same fluorescence lifetime (2.0 ± 0.1 ns) was measured for the fluorescent beads by using confocal or STED lifetime imaging. The instrument has been applied to study Alexa Fluor 594-phalloidin labeled F-actin-rich projections with dimensions smaller than the diffraction limit of light in cultured cells. Fluorescence lifetimes of the actin-rich projections range from 2.2 to 2.9 ns as measured by STED lifetime imaging.

Lesoine, Michael; Bose, Sayantan; Petrich, Jacob; Smith, Emily

2012-06-13T23:59:59.000Z

92

Global and local cancer risks after the Fukushima Nuclear Power Plant accident as seen from Chernobyl: A modeling study for  

E-Print Network [OSTI]

Chernobyl: A modeling study for radiocaesium (134 Cs & 137 Cs) Nikolaos Evangeliou a, , Yves Balkanski risks, prior to epidemiology, and compare them with those occurred after the Chernobyl accident the accident of Chernobyl. © 2013 Elsevier Ltd. All rights reserved. 1. Introduction Accidental releases

Mousseau, Timothy A.

93

Early Lung Cancer Detection Program  

Broader source: Energy.gov [DOE]

Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

94

Novel Strategies in Cancer Prevention and Fertility Preservation with Tamoxifen  

E-Print Network [OSTI]

Women at high risk for breast cancer are often also at high risk for ovarian cancer, reflecting similar risk factors and suggesting intertwined disease pathways and common prevention targets. A novel strategy to overcome ...

Ting, Alison

2009-04-23T23:59:59.000Z

95

Potential health risks from postulated accidents involving the Pu-238 RTG (radioisotope thermoelectric generator) on the Ulysses solar exploration mission  

SciTech Connect (OSTI)

Potential radiation impacts from launch of the Ulysses solar exploration experiment were evaluated using eight postulated accident scenarios. Lifetime individual dose estimates rarely exceeded 1 mrem. Most of the potential health effects would come from inhalation exposures immediately after an accident, rather than from ingestion of contaminated food or water, or from inhalation of resuspended plutonium from contaminated ground. For local Florida accidents (that is, during the first minute after launch), an average source term accident was estimated to cause a total added cancer risk of up to 0.2 deaths. For accidents at later times after launch, a worldwide cancer risk of up to three cases was calculated (with a four in a million probability). Upper bound estimates were calculated to be about 10 times higher. 83 refs.

Goldman, M. (California Univ., Davis, CA (USA)); Nelson, R.C. (EG and G Idaho, Inc., Idaho Falls, ID (USA)); Bollinger, L. (Air Force Inspection and Safety Center, Kirtland AFB, NM (USA)); Hoover, M.D. (Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (USA). Inhalation Toxicology Research Inst.); Templeton, W. (Pacific Northwest Lab., Richland, WA (USA)); Anspaugh, L. (Lawren

1990-11-02T23:59:59.000Z

96

B lifetimes and mixing at the Tevatron  

SciTech Connect (OSTI)

The authors present recent results on b-hadron lifetimes and mixing obtained from the analysis of the data collected at the Tevatron Collider by the CDF and D0 Collaborations in the period 2002-2004. Many lifetime measurements have been updated since the Summer 2004 conferences, sometimes improving significantly the accuracy. Likewise the measurement of the B{sub d} oscillation frequency has been updated. New limits on the B{sub s} oscillation frequency have been determined using for the first time Run II data.

Bedeschi, Franco; /INFN, Pisa

2005-05-01T23:59:59.000Z

97

Prompt Neutron Lifetime for the NBSR Reactor  

SciTech Connect (OSTI)

In preparation for the proposed conversion of the National Institute of Standards and Technology (NIST) research reactor (NBSR) from high-enriched uranium (HEU) to low-enriched uranium (LEU) fuel, certain point kinetics parameters must be calculated. We report here values of the prompt neutron lifetime that have been calculated using three independent methods. All three sets of calculations demonstrate that the prompt neutron lifetime is shorter for the LEU fuel when compared to the HEU fuel and longer for the equilibrium end-of-cycle (EOC) condition when compared to the equilibrium startup (SU) condition for both the HEU and LEU fuels.

Hanson, A.L.; Diamond, D.

2012-06-24T23:59:59.000Z

98

Out-of-field organ doses and associated radiogenic risks from para-aortic radiotherapy for testicular seminoma  

SciTech Connect (OSTI)

Purpose: The aims of this study were to (a) calculate the radiation dose to out-of-field organs from radiotherapy for stage I testicular seminoma and (b) estimate the associated radiogenic risks. Methods: Monte Carlo methodology was employed to model radiation therapy with typical anteroposterior and posteroanterior para-aortic fields on an anthropomorphic phantom simulating an average adult. The radiation dose received by all main and remaining organs that defined by the ICRP publication 103 and excluded from the treatment volume was calculated. The effect of field dimensions on each organ dose was determined. Additional therapy simulations were generated by introducing shielding blocks to protect the kidneys from primary radiation. The gonadal dose was employed to assess the risk of heritable effects for irradiated male patients of reproductive potential. The lifetime attributable risks (LAR) of radiotherapy-induced cancer were estimated using gender- and organ-specific risk coefficients for patient ages of 20, 30, 40, and 50 years old. The risk values were compared with the respective nominal risks. Results: Para-aortic irradiation to 20 Gy resulted in out-of-field organ doses of 5.0–538.6 mGy. Blocked field treatment led to a dose change up to 28%. The mean organ dose variation by increasing or decreasing the applied field dimensions was 18.7% ± 3.9% and 20.8% ± 4.5%, respectively. The out-of-field photon doses increased the lifetime intrinsic risk of developing thyroid, lung, bladder, prostate, and esophageal cancer by (0.1–1.4)%, (0.4–1.1)%, (2.5–5.4)%, (0.2–0.4)%, and (6.4–9.2)%, respectively, depending upon the patient age at exposure and the field size employed. A low risk for heritable effects of less than 0.029% was found compared with the natural incidence of these defects. Conclusions: Testicular cancer survivors are subjected to an increased risk for the induction of bladder and esophageal cancer following para-aortic radiotherapy. The probability for the appearance of any other malignant disease to out-of-field organs was slightly elevated in respect to the nominal cancer incidence rates.

Mazonakis, Michalis, E-mail: mazonak@med.uoc.gr; Berris, Theocharis; Damilakis, John [Department of Medical Physics, Faculty of Medicine, University of Crete, P. O. Box 2208, 71003 Iraklion, Crete (Greece)] [Department of Medical Physics, Faculty of Medicine, University of Crete, P. O. Box 2208, 71003 Iraklion, Crete (Greece); Varveris, Charalambos; Lyraraki, Efrossyni [Department of Radiotherapy and Oncology, University Hospital of Iraklion, 71110 Iraklion, Crete (Greece)] [Department of Radiotherapy and Oncology, University Hospital of Iraklion, 71110 Iraklion, Crete (Greece)

2014-05-15T23:59:59.000Z

99

E-Print Network 3.0 - assessment guidelines cancer Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the NYS Cancer Services Program Summary: cancer and should be referred to an appropriate health care provider for a full risk assessment which can... for risk assessment (http:...

100

E-Print Network 3.0 - asbestos-related lung cancer Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the level of risk for lung and other cancers. Methods We performed a meta... household coal use and lung cancer risk, and to explore ... Source: Collection: Environmental...

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

The effect of gender on Helicobacter pylori and gastric cancer  

E-Print Network [OSTI]

Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium ...

Sheh, Alexander

2011-01-01T23:59:59.000Z

102

High-Dose-Rate Brachytherapy Alone for Localized Prostate Cancer in Patients at Moderate or High Risk of Biochemical Recurrence  

SciTech Connect (OSTI)

Purpose: To evaluate genitourinary (GU) and gastrointestinal (GI) morbidity and biochemical control of disease in patients with localized prostate adenocarcinoma treated with escalating doses per fraction of high-dose rate brachytherapy alone. Methods and Materials: A total of 197 patients were treated with 34 Gy in four fractions, 36 Gy in four fractions, 31.5 Gy in three fractions, or 26 Gy in two fractions. Median follow-up times were 60, 54, 36, and 6 months, respectively. Results: Incidence of early Grade {>=} 3 GU morbidity was 3% to 7%, and Grade 4 was 0% to 4%. During the first 12 weeks, the highest mean International Prostate Symptom Score (IPSS) value was 14, and between 6 months and 5 years it was 8. Grade 3 or 4 early GI morbidity was not observed. The 3-year actuarial rate of Grade 3 GU was 3% to 16%, and was 3% to 7% for strictures requiring surgery (4-year rate). An incidence of 1% Grade 3 GI events was seen at 3 years. Late Grade 4 GU or GI events were not observed. At 3 years, 99% of patients with intermediate-risk and 91% with high-risk disease were free of biochemical relapse (log-rank p = 0.02). Conclusions: There was no significant difference in urinary and rectal morbidity between schedules. Biochemical control of disease in patients with intermediate and high risk of relapse was good.

Hoskin, Peter [Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex (United Kingdom); Rojas, Ana, E-mail: arc03@btconnect.com [Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex (United Kingdom); Lowe, Gerry; Bryant, Linda; Ostler, Peter; Hughes, Rob; Milner, Jessica; Cladd, Helen [Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex (United Kingdom)

2012-03-15T23:59:59.000Z

103

Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts  

E-Print Network [OSTI]

at high risk for breast cancer with MR imaging. Breast Can-Findings from the Breast Cancer Surveillance Consortium:women undergoing biopsy after screening mammography. Cancer

Kelly, KM; Dean, J; Comulada, WS; Lee, S-J

2010-01-01T23:59:59.000Z

104

Lifetime tests for MAC vertex chamber  

SciTech Connect (OSTI)

A vertex chamber for MAC was proposed to increase precision in the measurement of the B hadron and tau lepton lifetimes. Thin-walled aluminized mylar drift tubes were used for detector elements. A study of radiation hardness was conducted under the conditions of the proposed design using different gases and different operating conditions. (LEW)

Nelson, H.N.

1986-07-01T23:59:59.000Z

105

Do red giants have short mode lifetimes?  

E-Print Network [OSTI]

We show evidence that the red giant star ksi Hya has an oscillation mode lifetime, tau, of about 2 days significantly shorter than predicted by theory (tau = 17 days, Houdek & Gough 2002). If this is a general trend of red giants it would limit the prospects of asteroseismology on these stars because of poor coherence of the oscillations.

D. Stello; H. Kjeldsen; T. R. Bedding; D. Buzasi

2005-10-18T23:59:59.000Z

106

Sunitinib Plus Androgen Deprivation and Radiation Therapy for Patients With Localized High-Risk Prostate Cancer: Results From a Multi-institutional Phase 1 Study  

SciTech Connect (OSTI)

Purpose: To evaluate the feasibility of administering sunitinib in combination with androgen deprivation therapy and external-beam intensity modulated radiation therapy (XRT) in patients with localized high-risk prostate cancer. Methods and Materials: Seventeen men with localized adenocarcinoma of the prostate with cT2c-cT4 or Gleason 8-10 or prostate-specific antigen >20 ng/mL received initial androgen deprivation (leuprolide 22.5 mg every 12 weeks plus oral bicalutamide 50 mg daily) for 4-8 weeks before oral sunitinib 12.5, 25, or 37.5 mg daily for 4 weeks as lead-in, then concurrently with and 4 weeks after XRT (75.6 Gy in 42 fractions to prostate and seminal vesicles). A 3+3 sequential dose-escalation design was used to assess the frequency of dose-limiting toxicity (DLT) and establish a maximal tolerated dose of sunitinib. Results: Sunitinib at 12.5- and 25-mg dose levels was well tolerated. The first 4 patients enrolled at 37.5 mg experienced a DLT during lead-in, and a drug interaction between sunitinib and bicalutamide was suspected. The protocol was revised and concurrent bicalutamide omitted. Of the next 3 patients enrolled at 37.5 mg, 2 of 3 receiving concurrent therapy experienced DLTs during radiation: grade 3 diarrhea and grade 3 proctitis, respectively. Only 1 of 7 patients completed sunitinib at 37.5 mg daily, whereas 3 of 3 patients (25 mg as starting dose) and 3 of 4 patients (25 mg as reduced dose) completed therapy. Conclusions: The feasibility of combined vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR) inhibitor therapy, androgen deprivation, and radiation therapy for prostate cancer was established. Using a daily dosing regimen with lead-in, concurrent, and post-XRT therapy, the recommended phase 2 dose of sunitinib is 25 mg daily.

Corn, Paul G., E-mail: pcorn@mdanderson.org [Department of Genitourinary Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Song, Danny Y. [Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland (United States)] [Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland (United States); Heath, Elisabeth; Maier, Jordan [Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (United States)] [Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (United States); Meyn, Raymond [Department of Experimental Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)] [Department of Experimental Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Kuban, Deborah [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); DePetrillo, Thomas A. [Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts (United States)] [Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts (United States); Mathew, Paul, E-mail: pmathew@tuftsmedicalcenter.org [Department of Hematology-Oncology, Tufts Medical Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)] [Department of Hematology-Oncology, Tufts Medical Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

2013-07-01T23:59:59.000Z

107

Interval to Biochemical Failure Predicts Clinical Outcomes in Patients With High-Risk Prostate Cancer Treated by Combined-Modality Radiation Therapy  

SciTech Connect (OSTI)

Purpose: To validate the prognostic value of interval to biochemical failure (IBF) in patients with high-risk prostate cancer (HiRPCa) treated with combined-modality radiation therapy (CMRT) with or without androgen deprivation therapy (ADT). Methods and Materials: We conducted a retrospective review of HiRPCa (prostate-specific antigen >20 ng/mL, Gleason score [GS] 8-10, or clinical T stage T3-T4) treated with either dose-escalated external beam radiation therapy (EBRT) or CMRT. Interval to biochemical failure was classified as ?18 or >18 months from the end of all therapy to the date of biochemical failure (BF). Kaplan-Meier methods and Cox proportional hazards regression were used to evaluate the prognostic value of IBF ?18 months for distant metastasis (DM) and prostate cancer-specific mortality (PCSM). Results: Of 958 patients with a median follow-up of 63.2 months, 175 patients experienced BF. In those with BF, there were no differences in pretreatment clinical characteristics between the EBRT and CMRT groups, except for a higher proportion of patients with GS 8-10 in the CMRT group (70% vs 52%, P=.02). Median IBF after all therapy was 24.0 months (interquartile range 9.6-46.0) in the EBRT group and 18.9 months (interquartile range 9.2-34.5) in the CMRT group (P=.055). On univariate analysis, IBF ?18 months was associated with increased risk of DM and PCSM in the entire cohort and the individual EBRT and CMRT groups. On multivariate analysis, only GS 9-10 and IBF ?18 months, but not the radiation therapy regimen or ADT use, predicted DM (hazard ratio [HR] 3.7, P<.01, 95% confidence interval [CI] 1.4-10.3 for GS 9-10; HR 3.9, P<.0001, 95% CI 2.4-6.5 for IBF ?18 months) and PCSM (HR 14.8, P<.009, 95% CI 2.0-110 for GS 9-10; HR 4.4, P<.0001, 95% CI 2.4-8.1 for IBF ?18 months). Conclusions: Short IBF was highly prognostic for higher DM and PCSM in patients with HiRPCa. The prognostic value of IBF for DM and PCSM was not affected by the radiation therapy regimen or ADT use.

Shilkrut, Mark; McLaughlin, P. William [Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, Michigan (United States); Merrick, Gregory S. [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, West Virginia (United States)] [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, West Virginia (United States); Vainshtein, Jeffrey M.; Feng, Felix Y. [Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, Michigan (United States); Hamstra, Daniel A., E-mail: dhamm@med.umich.edu [Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, Michigan (United States)

2013-07-15T23:59:59.000Z

108

A study on planning organ at risk volume for the rectum using cone beam computed tomography in the treatment of prostate cancer  

SciTech Connect (OSTI)

In this study, we analyzed planning organ at risk volume (PRV) for the rectum using a series of cone beam computed tomographies (CBCTs) acquired during the treatment of prostate cancer and evaluated the dosimetric effect of different PRV definitions. Overall, 21 patients with prostate cancer were treated radically with 78 Gy in 39 fractions had in total 418 CBCTs, each acquired at the end of the first 5 fractions and then every alternate fraction. The PRV was generated from the Boolean sum volume of the rectum obtained from first 5 fractions (PRV-CBCT-5) and from all CBCTs (PRV-CBCT-All). The PRV margin was compared at the superior, middle, and inferior slices of the contoured rectum to compare PRV-CBCT-5 and PRV-CBCT-All. We also compared the dose received by the planned rectum (Rectum-computed tomography [CT]), PRV-CBCT-5, PRV-CBCT-All, and average rectum (CBCT-AV-dose-volume histogram [DVH]) at critical dose levels. The average measured rectal volume for all 21 patients for Rectum-CT, PRV-CBCT-5, and PRV-CBCT-All was 44.3 ± 15.0, 92.8 ± 40.40, and 121.5 ± 36.7 cm{sup 3}, respectively. For PRV-CBCT-All, the mean ± standard deviation displacement in the anterior, posterior, right, and left lateral directions in centimeters was 2.1 ± 1.1, 0.9 ± 0.5, 0.9 ± 0.8, and 1.1 ± 0.7 for the superior rectum; 0.8 ± 0.5, 1.1 ± 0.5, 1.0 ± 0.5, and 1.0 ± 0.5 for the middle rectum; and 0.3 ± 0.3; 0.9 ± 0.5; 0.4 ± 0.2, and 0.5 ± 0.3 for the inferior rectum, respectively. The first 5 CBCTs did not predict the PRV for individual patients. Our study shows that the PRV margin is different for superior, middle, and the inferior parts of the rectum, it is wider superiorly and narrower inferiorly. A uniform PRV margin does not represent the actual rectal variations during treatment for all treatment fractions. The large variation in interpatient rectal size implies a potential role for adaptive radiotherapy for prostate cancer.

Prabhakar, Ramachandran, E-mail: Ramachandran.Prabhakar@petermac.org [Department of Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, Victoria (Australia); RMIT University, Melbourne (Australia); Oates, Richard; Jones, Daryl [Radiation Therapy Services, Peter MacCallum Cancer Centre, Melbourne (Australia); Kron, Tomas [Department of Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, Victoria (Australia); RMIT University, Melbourne (Australia); Cramb, Jim [Department of Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, Victoria (Australia); Foroudi, Farshad [Radiation Therapy Services, Peter MacCallum Cancer Centre, Melbourne (Australia); Geso, Moshi [RMIT University, Melbourne (Australia); Gill, Suki [Radiation Therapy Services, Peter MacCallum Cancer Centre, Melbourne (Australia)

2014-04-01T23:59:59.000Z

109

High-Dose-Rate Brachytherapy as Monotherapy Delivered in Two Fractions Within One Day for Favorable/Intermediate-Risk Prostate Cancer: Preliminary Toxicity Data  

SciTech Connect (OSTI)

Purpose: To report the toxicity profile of high-dose-rate (HDR)-brachytherapy (BT) as monotherapy in a Human Investigation Committee-approved study consisting of a single implant and two fractions (12 Gy Multiplication-Sign 2) for a total dose of 24 Gy, delivered within 1 day. The dose was subsequently increased to 27 Gy (13.5 Gy Multiplication-Sign 2) delivered in 1 day. We report the acute and early chronic genitourinary and gastrointestinal toxicity. Methods and Materials: A total of 173 patients were treated between December 2005 and July 2010. However, only the first 100 were part of the IRB-approved study and out of these, only 94 had a minimal follow-up of 6 months, representing the study population for this preliminary report. All patients had clinical Stage T2b or less (American Joint Committee on Cancer, 5th edition), Gleason score 6-7 (3+4), and prostate-specific antigen level of {<=}12 ng/mL. Ultrasound-guided HDR-BT with real-time dosimetry was used. The prescription dose was 24 Gy for the first 50 patients and 27 Gy thereafter. The dosimetric goals and constraints were the same for the two dose groups. Toxicity was scored using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3. The highest toxicity scores encountered at any point during follow-up are reported. Results: The median follow-up was 17 months (range, 6-40.5). Most patients had Grade 0-1 acute toxicity. The Grade 2 acute genitourinary toxicity was mainly frequency/urgency (13%), dysuria (5%), hematuria, and dribbling/hesitancy (2%). None of the patients required a Foley catheter at any time; however, 8% of the patients experienced transient Grade 1 diarrhea. No other acute gastrointestinal toxicities were found. The most common chronic toxicity was Grade 2 urinary frequency/urgency in 16% of patients followed by dysuria in 4% of patients; 2 patients had Grade 2 rectal bleeding and 1 had Grade 4, requiring laser treatment. Conclusions: Favorable-risk prostate cancer patients treated with a single implant HDR-BT to 24-27 Gy in two fractions within 1 day have excellent tolerance with minimal acute and chronic toxicity. Longer follow-up is needed to confirm these encouraging early results.

Ghilezan, Michel, E-mail: mghilezan@beaumont.edu [Department of Radiation Oncology, William Beaumont Hospital and Rose Cancer Institute, Royal Oak, Michigan (United States); Martinez, Alvaro; Gustason, Gary; Krauss, Daniel; Antonucci, J. Vito; Chen, Peter; Fontanesi, James; Wallace, Michelle; Ye Hong; Casey, Alyse; Sebastian, Evelyn; Kim, Leonard; Limbacher, Amy [Department of Radiation Oncology, William Beaumont Hospital and Rose Cancer Institute, Royal Oak, Michigan (United States)

2012-07-01T23:59:59.000Z

110

LUMINESCENCE LIFETIME INSTRUMENTATION DEVELOPMENT FOR MULTI-DYE ANALYSIS  

E-Print Network [OSTI]

Start Time of Window 4 ?1 Shorter Lifetime in Two Dye System ?2 Longer Lifetime in Two Dye System LED Light Emitting Diode PMT Photomultiplier Tube DAQ Data Acquisition Board SD Standard Deviation 95% CI 95% Confidence Interval SNR Signal...

Shadfan, Adam

2011-08-08T23:59:59.000Z

111

Photovoltaic Lifetime & Degradation Science Statistical Pathway Development: Acrylic Degradation  

E-Print Network [OSTI]

Photovoltaic Lifetime & Degradation Science Statistical Pathway Development: Acrylic Degradation, USA ABSTRACT In order to optimize and extend the life of photovoltaics (PV) modules, scientific photovoltaics. The statisti- cally significant relationships were investigated using lifetime and degradation

Rollins, Andrew M.

112

Degradation Pathway Models for Photovoltaics Module Lifetime Performance  

E-Print Network [OSTI]

Degradation Pathway Models for Photovoltaics Module Lifetime Performance Nicholas R. Wheeler, Laura data from Underwriter Labs, featuring measurements taken on 18 identical photovoltaic (PV) modules in modules and their effects on module performance over lifetime. Index Terms--photovoltaics, statistical

Rollins, Andrew M.

113

Mass and Lifetime Measurements in Storage Rings  

SciTech Connect (OSTI)

Masses of nuclides covering a large area of the chart of nuclides can be measured in storage rings where many ions circulate at the same time. In this paper the recent progress in the analysis of Schottky mass spectrometry data is presented as well as the technical improvements leading to higher accuracy for isochronous mass measurements with a time-of-flight detector. The high sensitivity of the Schottky method down to single ions allows to measure lifetimes of nuclides by observing mother and daughter nucleus simultaneously. In this way we investigated the decay of bare and H-like 140Pr. As we could show the lifetime can be even shortened compared to those of atomic nuclei despite of a lower number of electrons available for internal conversion or electron capture.All these techniques will be implemented with further improvements at the storage rings of the new FAIR facility at GSI in the future.

Weick, H.; Beckert, K.; Beller, P.; Bosch, F.; Dimopoulou, C.; Kozhuharov, C.; Kurcewicz, J.; Mazzocco, M.; Nociforo, C.; Nolden, F.; Steck, M.; Sun, B.; Winkler, M. [Gesellschaft fuer Schwerionenforschung mbH, 64291 Darmstadt (Germany); Brandau, C.; Chen, L.; Geissel, H.; Knoebel, R.; Litvinov, S. A.; Litvinov, Yu. A.; Scheidenberger, C. [Gesellschaft fuer Schwerionenforschung mbH, 64291 Darmstadt (Germany); II. Phys. Institut, Justus-Liebig-Universitaet Giessen, 35392 Giessen (Germany)] (and others)

2007-05-22T23:59:59.000Z

114

Activation of protein kinase B (PKB/Akt) and risk of lung cancer among rural women in India who cook with biomass fuel  

SciTech Connect (OSTI)

The impact of indoor air pollution (IAP) from biomass fuel burning on the risk of carcinogenesis in the airways has been investigated in 187 pre-menopausal women (median age 34 years) from eastern India who cooked exclusively with biomass and 155 age-matched control women from same locality who cooked with cleaner fuel liquefied petroleum gas. Compared with control, Papanicolau-stained sputum samples showed 3-times higher prevalence of metaplasia and 7-times higher prevalence of dysplasia in airway epithelial cell (AEC) of biomass users. Immunocytochemistry showed up-regulation of phosphorylated Akt (p-Akt{sup ser473} and p-Akt{sup thr308}) proteins in AEC of biomass users, especially in metaplastic and dysplastic cells. Compared with LPG users, biomass-using women showed marked rise in reactive oxygen species (ROS) generation and depletion of antioxidant enzyme, superoxide dismutase (SOD) indicating oxidative stress. There were 2–5 times more particulate pollutants (PM{sub 10} and PM{sub 2.5}), 72% more nitrogen dioxide and 4-times more particulate-laden benzo(a)pyrene, but no change in sulfur dioxide in indoor air of biomass-using households, and high performance liquid chromatography estimated 6-fold rise in the concentration of benzene metabolite trans,trans-muconic acid (t,t-MA) in urine of biomass users. Metaplasia and dysplasia, p-Akt expression and ROS generation were positively associated with PM and t,t-MA levels. It appears that cumulative exposure to biomass smoke increases the risk of lung carcinogenesis via oxidative stress-mediated activation of Akt signal transduction pathway. -- Highlights: ? Carcinogenesis in airway cells was examined in biomass and LPG using women. ? Metaplasia and dysplasia of epithelial cells were more prevalent in biomass users. ? Change in airway cytology was associated with oxidative stress and Akt activation. ? Biomass users had greater exposure to respirable PM, B(a)P and benzene. ? Cooking with biomass increases cancer risk in the airways via Akt activation.

Roychoudhury, Sanghita; Mondal, Nandan Kumar; Mukherjee, Sayali; Dutta, Anindita; Siddique, Shabana; Ray, Manas Ranjan, E-mail: manasrray@rediffmail.com

2012-02-15T23:59:59.000Z

115

aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer  

E-Print Network [OSTI]

--22000000 58 Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer

Paxton, Anthony T.

116

Anterior Myocardial Territory May Replace the Heart as Organ at Risk in Intensity-Modulated Radiotherapy for Left-Sided Breast Cancer  

SciTech Connect (OSTI)

Purpose: We investigated whether the heart could be replaced by the anterior myocardial territory (AMT) as the organ at risk (OAR) in intensity-modulated radiotherapy (IMRT) of the breast for patients with left-sided breast cancer. Methods and Materials: Twenty-three patients with left-sided breast cancer who received postoperative radiation after breast-conserving surgery were studied. For each patient, we generated five IMRT plans including heart (H), left ventricle (LV), AMT, LV+AMT, and H+LV as the primary OARs, respectively, except both lungs and right breast, which corresponded to IMRT(H), IMRT(LV), IMRT(AMT), IMRT(LV+AMT), and IMRT(H+LV). For the planning target volumes and OARs, the parameters of dose-volume histograms were compared. Results: The homogeneity index, conformity index, and coverage index were not compromised significantly in IMRT(AMT), IMRT(LV) and IMRT(LV+ AMT), respectively, when compared with IMRT(H). The mean dose to the heart, LV, and AMT decreased 5.3-21.5% (p < 0.05), 19.9-29.5% (p < 0.05), and 13.3-24.5% (p < 0.05), respectively. Similarly, the low (e.g., V5%), middle (e.g., V20%), and high (e.g., V30%) dose-volume of the heart, LV, and AMT decreased with different levels. The mean dose and V10% of the right lung increased by 9.2% (p < 0.05) and 27.6% (p < 0.05), respectively, in IMRT(LV), and the mean dose and V5% of the right breast decreased significantly in IMRT(AMT) and IMRT(LV+AMT). IMRT(AMT) was the preferred plan and was then compared with IMRT(H+LV); the majority of dose-volume histogram parameters of OARs including the heart, LV, AMT, both lungs, and the right breast were not statistically different. However, the low dose-volume of LV increased and the middle dose-volume decreased significantly (p < 0.05) in IMRT(AMT). Also, those of the right lung (V10%, V15%) and right breast (V5%, V10%) decreased significantly (p < 0.05). Conclusions: The AMT may replace the heart as the OAR in left-sided breast IMRT after breast-conserving surgery to decrease the radiation dose to the heart.

Tan Wenyong [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan (China); Liu Dong [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Xue Chenbin [Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan (China); Xu Jiaozhen; Li Beihui [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Chen Zhengwang [Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan (China); Hu Desheng [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Wang Xionghong, E-mail: tanwyym@yahoo.com.cn [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China)

2012-04-01T23:59:59.000Z

117

Final report on reliability and lifetime prediction.  

SciTech Connect (OSTI)

This document highlights the important results obtained from the subtask of the Goodyear CRADA devoted to better understanding reliability of tires and to developing better lifetime prediction methods. The overall objective was to establish the chemical and physical basis for the degradation of tires using standard as well as unique models and experimental techniques. Of particular interest was the potential application of our unique modulus profiling apparatus for assessing tire properties and for following tire degradation. During the course of this complex investigation, extensive relevant information was generated, including experimental results, data analyses and development of models and instruments. Detailed descriptions of the findings are included in this report.

Gillen, Kenneth Todd; Wise, Jonathan; Jones, Gary D.; Causa, Al G. [Goodyear Tire and Rubber Co., Akron, OH; Terrill, Edward R. [Goodyear Tire and Rubber Co., Akron, OH; Borowczak, Marc [Goodyear Tire and Rubber Co., Akron, OH

2012-12-01T23:59:59.000Z

118

Skin cancer is the most com-mon form of cancer in the United  

E-Print Network [OSTI]

Skin cancer is the most com- mon form of cancer in the United States. Excessive and unprotected exposure to the sun's ultraviolet radiation (UV light) is the primary risk factor for skin cancer. Howev- er, skin cancer is one of the most preventable types of cancer! The damaging and cumulative effects

119

Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer  

E-Print Network [OSTI]

Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer Society Cancer and Paolo Boffetta, MD, MPH3 In 1994, the International Agency for Research on Cancer (IARC) classified wood dust as a human carcinogen, based on very strong evidence of a carcinogenic risk of sino-nasal cancer

Salzman, Daniel

120

Critical dose and toxicity index of organs at risk in radiotherapy: Analyzing the calculated effects of modified dose fractionation in non–small cell lung cancer  

SciTech Connect (OSTI)

To increase the efficacy of radiotherapy for non–small cell lung cancer (NSCLC), many schemes of dose fractionation were assessed by a new “toxicity index” (I), which allows one to choose the fractionation schedules that produce less toxic treatments. Thirty-two patients affected by non resectable NSCLC were treated by standard 3-dimensional conformal radiotherapy (3DCRT) with a strategy of limited treated volume. Computed tomography datasets were employed to re plan by simultaneous integrated boost intensity-modulated radiotherapy (IMRT). The dose distributions from plans were used to test various schemes of dose fractionation, in 3DCRT as well as in IMRT, by transforming the dose-volume histogram (DVH) into a biological equivalent DVH (BDVH) and by varying the overall treatment time. The BDVHs were obtained through the toxicity index, which was defined for each of the organs at risk (OAR) by a linear quadratic model keeping an equivalent radiobiological effect on the target volume. The less toxic fractionation consisted in a severe/moderate hyper fractionation for the volume including the primary tumor and lymph nodes, followed by a hypofractionation for the reduced volume of the primary tumor. The 3DCRT and IMRT resulted, respectively, in 4.7% and 4.3% of dose sparing for the spinal cord, without significant changes for the combined-lungs toxicity (p < 0.001). Schedules with reduced overall treatment time (accelerated fractionations) led to a 12.5% dose sparing for the spinal cord (7.5% in IMRT), 8.3% dose sparing for V{sub 20} in the combined lungs (5.5% in IMRT), and also significant dose sparing for all the other OARs (p < 0.001). The toxicity index allows to choose fractionation schedules with reduced toxicity for all the OARs and equivalent radiobiological effect for the tumor in 3DCRT, as well as in IMRT, treatments of NSCLC.

Pedicini, Piernicola, E-mail: ppiern@libero.it [Service of Medical Physics, I.R.C.C.S. Regional Cancer Hospital C.R.O.B, Rionero in Vulture (Italy); Strigari, Lidia [Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome (Italy); Benassi, Marcello [Service of Medical Physics, Scientific Institute of Tumours of Romagna I.R.S.T., Meldola (Italy); Caivano, Rocchina [Service of Medical Physics, I.R.C.C.S. Regional Cancer Hospital C.R.O.B, Rionero in Vulture (Italy); Fiorentino, Alba [U.O. of Radiotherapy, I.R.C.C.S. Regional Cancer Hospital C.R.O.B., Rionero in Vulture (Italy); Nappi, Antonio [U.O. of Nuclear Medicine, I.R.C.C.S. Regional Cancer Hospital C.R.O.B., Rionero in Vulture (Italy); Salvatore, Marco [U.O. of Nuclear Medicine, I.R.C.C.S. SDN Foundation, Naples (Italy); Storto, Giovanni [U.O. of Nuclear Medicine, I.R.C.C.S. Regional Cancer Hospital C.R.O.B., Rionero in Vulture (Italy)

2014-04-01T23:59:59.000Z

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121

Identification and characterisation of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk  

E-Print Network [OSTI]

Department of 57 Neurosurgery, Chang Gung Memorial Hospital, Taoyuan County, 333, Taiwan, 3Department 58 of Internal Medicine, University of Utah School of Medicine, Salt Lake City Utah 84108-59 1266 USA, 4Centre for Cancer Genetic Epidemiology, Department... , London 77 School of Hygiene and Tropical Medicine, London WC1E 7HT, UK, 17Breakthrough Breast 78 4 Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK, 18Division 79 of Cancer Studies, Kings College London, Guy's Hospital...

Lin, Wei-Yu; Camp, Nicola J.; Ghoussaini, Maya; Beesley, Jonathan; Michailidou, Kyriaki; Hopper, John L.; Apicella, Carmel; Stone, Jennifer; Schmidt, Marjanka K.; Broeks, Annegien; Van't Veer, Laura J.; Rutgers, Emiel J. Th.; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Fasching, Peter A.; Haeberle, Lothar; Ekici, Arif B.; Beckmann, Matthias W.; Peto, Julian; dos-Santos-Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Sawyer, Elinor J.; Cheng, Timothy; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Marmé, Frederik; Surowy, Harald M.; Burwinkel, Barbara; Guénel, Pascal; Truong, Thérèse; Menegaux, Florence; Mulot, Claire; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Benitez, Javier; Zamora, M. Pilar; Perez, Jose Ignacio Arias; Menéndez, Primitiva; González-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Álvarez, Nuria; Herrero, Daniel; Anton-Culver, Hoda; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Meindl, Alfons; Lichtner, Peter; Schmutzler, Rita K.; Müller-Myhsok, Bertram; Brauch, Hiltrud; Brüning, Thomas; Ko, Yon-Dschun; The GENICA Network; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Nevanlinna, Heli; Aittomäki, Kristiina; Blomqvist, Carl; Khan, Sofia; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Horio, Akiyo; Bogdanova, Natalia V.; Antonenkova, Natalia N.; Dörk, Thilo; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; kConFab Investigators; Australian Ovarian Cancer Study Group; Wu, Anna H.; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O.; Neven, Patrick; Wauters, Els; Wildiers, Hans; Lambrechts, Diether; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Bonanni, Bernardo; Couch, Fergus J.; Wang, Xianshu; Vachon, Celine; Purrington, Kristen; Giles, Graham G.; Milne, Roger; McLean, Catriona; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Teo, Soo Hwang; Yip, Cheng Har; Hassan, Norhashimah; Vithana, Eranga Nishanthie; Kristensen, Vessela; Zheng, Wei; Deming-Halverson, Sandra; Shrubsole, Martha; Long, Jirong; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Tchatchou, Sandrine; Devilee, Peter; Tollenaar, Robert A. E. M.; Seynaeve, Caroline; Van Asperen, Christi J.; García-Closas, Montserrat; Figueroa, Jonine; Lissowska, Jolanta; Brinton, Louise; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Brand, Judith S.; Hooning, Maartje J.; Hollestelle, Antoinette; van den Ouweland, Ans M. W.; Jager, Agnes; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Cross, Simon S.; Reed, Malcolm W. R.; Blot, William; Signorello, Lisa B.; Cai, Qiuyin; Pharoah, Paul D. P.; Perkins, Barbara; Shah, Mitul; Blows, Fiona M.; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Hartman, Mikael; Miao, Hui; Chia, Kee Seng; Putti, Thomas Choudary; Hamann, Ute; Luccarini, Craig; Baynes, Caroline; Ahmed, Shahana; Maranian, Mel; Healey, Catherine S.; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Slager, Susan; Toland, Amanda E.; Yannoukakos, Drakoulis; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Ding, Shian-ling; Ashworth, Alan; Jones, Michael; Orr, Nick; Swerdlow, Anthony J.; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel F.; Bui, Quang M.; Chanock, Stephen J.; Hunter, David J.; Hein, Rebecca; Dahmen, Norbert; Beckmann, Lars; Aaltonen, Kirsimari; Muranen, Taru A.; Heikkinen, Tuomas; Irwanto, Astrid; Rahman, Nazneen; Turnbull, Clare; The Breast and Ovarian Cancer Susceptibility Study; Waisfisz, Quinten; Meijers-Heijboer, Hanne E. J.; Adank, Muriel A.; van der Luijt, Rob B.; Hall, Per; Chenevix-Trench, Georgia; Dunning, Alison; Easton, Douglas F.; Cox, Angela

2014-08-28T23:59:59.000Z

122

E-Print Network 3.0 - antibody-targeted radiation cancer Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is an increased risk of cancer. The amount of risk depends on the amount of radiation dose... low-level radiation exposure increases one's risk of cancer, medical studies have...

123

The lifetime of excess atmospheric carbon dioxide  

SciTech Connect (OSTI)

Since the beginning of the industrial revolution human activity has significantly altered biogeochemical cycling on a global scale. The uncertainties of future climate change rests partly on issues of physical-climate system dynamics and their representation in general circulation models. However understanding the carbon cycle is a key to comprehending the changing terrestrial biosphere and to developing a reasonable range of future concentrations of greenhouse gases. The authors look at correction of model uncertainties in the examination of the lifetime of carbon dioxide. The two difficulties analysed are as follows: (1) most model-derived estimates of the relaxation of the concentration of CO2 reveal a function which is not always well approximated by weighted sums of exponentials; (2) the function c(t) is quite sensitive to assumptions about the terrestrial biosphere and the relaxation experiment. 51 refs., 15 figs., 7 tabs.

Moore, B. III; Braswell, B.H. (Univ. of New Hampshire, Durham, NH (United States))

1994-03-01T23:59:59.000Z

124

Statistical and Domain Analytics Applied to PV Module Lifetime...  

Broader source: Energy.gov (indexed) [DOE]

This process exemplifies the development of a methodology to determine lifetime and degradation pathways present in modules and their eects on module perfor- and is...

125

Statistical and Domain Analytics Applied to PV Module Lifetime...  

Broader source: Energy.gov (indexed) [DOE]

Degradation Science Statistical and Domain Analytics Applied to PV Module Lifetime and Degradation Science Presented at the PV Module Reliability Workshop, February 26 - 27...

126

Societal lifetime cost of hydrogen fuel cell vehicles  

E-Print Network [OSTI]

Societal lifetime cost of hydrogen fuel cell vehiclesthe societal cost of hydrogen fuel-cell vehicles with modelsand running costs) than hydrogen fuel-cell vehicles in 2030.

Sun, Yongling; Ogden, J; Delucchi, Mark

2010-01-01T23:59:59.000Z

127

European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version  

E-Print Network [OSTI]

European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version REVIEW Energy balance and cancers M overweight, have been recognized as risk factors for the development of cancers. Human epidemiological

Boyer, Edmond

128

Inherited risk for common disease  

E-Print Network [OSTI]

Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

Banava, Helen

2007-01-01T23:59:59.000Z

129

Experimental Investigation of Excited-State Lifetimes in Atomic Ytterbium  

SciTech Connect (OSTI)

Lifetimes of 21 excited states in atomic Yb were measured using time-resolved fluorescence detection following pulsed laser excitation. The lifetime of the 4f{sup 14}5d6s {sup 3}D{sub 1} state, which is of particular importance for a proposed study of parity nonconservation in atoms, was measured to be 380(30) ns.

Bowers, C.J.; Budker, D.; Commins, E.D.; DeMille, D.; Freedman, S.J.; Nguyen, A.-T.; Shang, S.-Q.; /UC, Berkeley; Zolotorev, M.; /SLAC

2011-11-15T23:59:59.000Z

130

BAYESIAN RELIABILITY MODELING FOR MASKED SYSTEM LIFETIME DATA  

E-Print Network [OSTI]

BAYESIAN RELIABILITY MODELING FOR MASKED SYSTEM LIFETIME DATA Lynn KUO \\Lambda Department to fail. The objective is to make inferences for the reliability of the components. In this paper we Title: Reliability Inference for Masked System Lifetime Data. 1. Introduction In the masked system

Kuo, Lynn

131

Neutron lifetime measurements using gravitationally trapped ultracold neutrons  

SciTech Connect (OSTI)

Our experiment using gravitationally trapped ultracold neutrons (UCN) to measure the neutron lifetime is reviewed. Ultracold neutrons were trapped in a material bottle covered with perfluoropolyether. The neutron lifetime was deduced from comparison of UCN losses in the traps with different surface-to-volume ratios. The precise value of the neutron lifetime is of fundamental importance to particle physics and cosmology. In this experiment, the UCN storage time is brought closer to the neutron lifetime than in any experiments before: the probability of UCN losses from the trap was only 1% of that for neutron {beta} decay. The neutron lifetime obtained, 878.5{+-}0.7{sub stat}{+-}0.3{sub sys} s, is the most accurate experimental measurement to date.

Serebrov, A. P.; Varlamov, V. E.; Kharitonov, A. G.; Fomin, A. K.; Krasnoschekova, I. A.; Lasakov, M. S.; Taldaev, R. R.; Vassiljev, A. V.; Zherebtsov, O. M. [Petersburg Nuclear Physics Institute, Russian Academy of Sciences, RU-188300 Gatchina, Leningrad District (Russian Federation); Pokotilovski, Yu. N. [Joint Institute for Nuclear Research, RU-141980 Dubna, Moscow Region (Russian Federation); Geltenbort, P. [Institut Max von Laue Paul Langevin, Boite Postal 156, F-38042 Grenoble Cedex 9 (France)

2008-09-15T23:59:59.000Z

132

Neutron lifetime measurements using gravitationally trapped ultracold neutrons  

E-Print Network [OSTI]

Our experiment using gravitationally trapped ultracold neutrons (UCN) to measure the neutron lifetime is reviewed. Ultracold neutrons were trapped in a material bottle covered with perfluoropolyether. The neutron lifetime was deduced from comparison of UCN losses in the traps with different surface-to-volume ratios. The precise value of the neutron lifetime is of fundamental importance to particle physics and cosmology. In this experiment, the UCN storage time is brought closer to the neutron lifetime than in any experiments before:the probability of UCN losses from the trap was only 1% of that for neutron beta decay. The neutron lifetime obtained,878.5+/-0.7stat+/-0.3sys s, is the most accurate experimental measurement to date.

A. P. Serebrov; V. E. Varlamov; A. G. Kharitonov; A. K. Fomin; Yu. N. Pokotilovski; P. Geltenbort; I. A. Krasnoschekova; M. S. Lasakov; R. R. Taldaev; A. V. Vassiljev; O. M. Zherebtsov

2007-02-06T23:59:59.000Z

133

Produced water radionuclide hazard/risk assessment, Phase 1  

SciTech Connect (OSTI)

Petroleum production may be accompanied by the production of saline water, called ``produced water.`` Produced water discharged into freshwater streams, estuaries, coastal and outer continental shelf waters can contained enhanced levels of radium isotopes. This document reports on the first phase of a study to estimate the risk to human health and the environment from radium discharged in produced water. The study involved five major steps: (1) evaluate the usefulness of available produced water outfall data for developing estimates of radium environmental concentrations; (2) review the literature on the bioaccumulation of radium by aquatic organism; (3) review the literature on the effects of radiation on aquatic organisms; (4) review the information available concerning the human health risks associated with exposure to Ra-226 and Ra-228 and (5) perform a conservative, screening-level assessment of the health and environmental risks posed by Ra-226 and Ra-228 discharged in produced waters. A screening-level analysis was performed to determine whether radium discharged to coastal Louisiana in produced waters presents potential health or environmental risks requiring further study. This conservative assessment suggested that no detectable impact on populations of fish, molluscs or crustaceans from radium discharged in produced waters is likely. The analysis also suggested that there is a potential for risk were an individual to ingest a large amount of seafood harvested near a produced water discharge point over a lifetime. The number of excess cancers predicted per year under a conservative scenario is comparable to those expected to result from background concentrations of radium.

Hamilton, L.D.; Meinhold, A.F.; Nagy, J.

1991-06-01T23:59:59.000Z

134

Produced water radionuclide hazard/risk assessment, Phase 1  

SciTech Connect (OSTI)

Petroleum production may be accompanied by the production of saline water, called produced water.'' Produced water discharged into freshwater streams, estuaries, coastal and outer continental shelf waters can contained enhanced levels of radium isotopes. This document reports on the first phase of a study to estimate the risk to human health and the environment from radium discharged in produced water. The study involved five major steps: (1) evaluate the usefulness of available produced water outfall data for developing estimates of radium environmental concentrations; (2) review the literature on the bioaccumulation of radium by aquatic organism; (3) review the literature on the effects of radiation on aquatic organisms; (4) review the information available concerning the human health risks associated with exposure to Ra-226 and Ra-228 and (5) perform a conservative, screening-level assessment of the health and environmental risks posed by Ra-226 and Ra-228 discharged in produced waters. A screening-level analysis was performed to determine whether radium discharged to coastal Louisiana in produced waters presents potential health or environmental risks requiring further study. This conservative assessment suggested that no detectable impact on populations of fish, molluscs or crustaceans from radium discharged in produced waters is likely. The analysis also suggested that there is a potential for risk were an individual to ingest a large amount of seafood harvested near a produced water discharge point over a lifetime. The number of excess cancers predicted per year under a conservative scenario is comparable to those expected to result from background concentrations of radium.

Hamilton, L.D.; Meinhold, A.F.; Nagy, J.

1991-06-01T23:59:59.000Z

135

ASSOCIATIONS BETWEEN POLYMORPHISMS AND ABNORMAL RPFNA CYTOMORPHOLOGY IN HIGH-RISK POSTMENOPAUSAL WOMEN TAKING HRT  

E-Print Network [OSTI]

Introduction: Hormone replacement therapy (HRT) is an effective treatment option for women experiencing symptoms of menopause but long-term use is associated with an increased risk of breast cancer. HRT-related breast cancer risk is dependent...

Michaels, Whitney Lee

2014-08-31T23:59:59.000Z

136

Krypton-85 health risk assessment for a nuclear fuel reprocessing plant  

SciTech Connect (OSTI)

The risks involved in the routine release of /sup 85/Kr from nuclear fuel reprocessing operations to the environment were compared to those resulting from the capture and storage of /sup 85/Kr. Instead of releasing the /sup 85/Kr to the environment when fuel is reprocessed, it can be captured, immobilized and stored. Two alternative methods of capturing /sup 85/Kr (cryogenic distillation and fluorocarbon absorption) and one method of immobilizing the captured gas (ion implantation/sputtering) were theoretically incorporated into a representative fuel reprocessing plant, the Barnwell Nuclear Fuel Plant, even though there are no known plans to start up this facility. Given the uncertainties in the models used to generate lifetime risk numbers (0.02 to 0.027 radiation induced fatal cancers expected in the occupational workforce and 0.017 fatal cancers in the general population), the differences in total risks for the three situations, (i.e., no-capture and two-capture alternatives) cannot be considered meaningful. It is possible that no risks would occur from any of the three situations. There is certainly no reason to conclude that risks from /sup 85/Kr routinely released to the environment are greater than those that would result from the other two situations considered. Present regulations mandate recovery and disposal of /sup 85/Kr from the off gases of a facility reprocessing spent fuel from commercial sources. Because of the lack of a clear-cut indication that recovery woud be beneficial, it does not seem prudent to burden the facilities with a requirement for /sup 85/Kr recovery, at least until operating experience demonstrates the incentive. The probable high aging of the early fuel to be processed and the higher dose resulting from the release of the unregulated /sup 3/H and /sup 14/C also encourage delaying implementation of the /sup 85/Kr recovery in the early plants.

Mellinger, P.J.; Brackenbush, L.W.; Tanner, J.E.; Gilbert, E.S.

1984-08-01T23:59:59.000Z

137

The Lifetime of a beautiful and charming meson: B_c lifetime measured using the D0 detector  

SciTech Connect (OSTI)

Using approximately 1.3 fb{sup -1} of data collected by the D0 detector between 2002 and 2006, the lifetime of the B{sub c}{sup {+-}} meson is studied in the B{sub c}{sup {+-}} {yields} J/{psi}{mu}{sup {+-}} + X final state. Using an unbinned likelihood simultaneous fit to J/{psi} + {mu} invariant mass and lifetime distributions, a signal of 810 {+-} 80(stat.) candidates is estimated and a lifetime measurement made of: {tau}(B{sub c}{sup {+-}}) = 0.448{sub -0.036}{sup +0.038}(stat) {+-} 0.032(sys) ps.

Welty-Rieger, Leah Christine; /Indiana U.

2008-09-01T23:59:59.000Z

138

Measurement of the lifetimes of B meson mass eigenstates  

E-Print Network [OSTI]

In this dissertation, we present the results of the average lifetime measurements in ..., ..., and ... decays, as well as the results of a time-dependent angular analysis of ... and ... decays. The time-dependent angular ...

Anikeev, Konstantin

2004-01-01T23:59:59.000Z

139

Direct Measurements of the Lifetime of Heavy Hypernuclei  

E-Print Network [OSTI]

The lifetime of a Lambda particle embedded in a nucleus (hypernucleus) decreases from that of free Lambda decay due to the opening of the Lambda N to NN weak decay channel. However, it is generally believed that the lifetime of a hypernucleus attains a constant value (saturation) for medium to heavy hypernuclear masses, yet this hypothesis has been difficult to verify. The present paper reports a direct measurement of the lifetime of medium-heavy hypernuclei produced with a photon-beam from Fe, Cu, Ag, and Bi targets. The recoiling hypernuclei were detected by a fission fragment detector using low-pressure multi-wire proportional chambers. The experiment agrees remarkably well with the only previously-measured single-species heavy-hypernucleus lifetime, that of Fe56_Lambda at KEK, and has significantly higher precision. The experiment disagrees with the measured lifetime of an unknown combination of heavy hypernuclei with 180lifetime decrease.

X. Qiu; L. Tang; A. Margaryan; P. Achenbach; A. Ahmidouch; I. Albayrak; D. Androic; A. Asaturyan; R. Asaturyan; O. Ates; R. Badui; P. Baturin; W. Boeglin; J. Bono; E. Brash; P. Carter; C. Chen; X. Chen; A. Chiba; E. Christy; M. M. Dalton; S. Danagoulian; R. De Leo; D. Doi; M. Elaasar; R. Ent; H. Fenker; Y. Fujii; M. Furic; M. Gabrielyan; L. Gan; F. Garibaldi; D. Gaskell; A. Gasparian; T. Gogami; O. Hashimoto; T. Horn; B. Hu; E. V. Hungerford; M. Jones; H. Kanda; M. Kaneta; M. Kawai; D. Kawama; H. Khanal; M. Kohl; A. Liyanage; W. Luo; K. Maeda; P. Markowitz; T. Maruta; A. Matsumura; V. Maxwell; A. Mkrtchyan; H. Mkrtchyan; S. Nagao; S. N. Nakamura; A. Narayan; C. Neville; G. Niculescu; M. I. Niculescu; A. Nunez; Nuruzzaman; Y. Okayasu; T. Petkovic; J. Pochodzalla; J. Reinhold; V. M. Rodriguez; C. Samanta; B. Sawatzky; T. Seva; A. Shichijo; V. Tadevosyan; N. Taniya; K. Tsukada; M. Veilleux; W. Vulcan; F. R. Wesselmann; S. A. Wood; L. Ya; T. Yamamoto; Z. Ye; K. Yokota; L. Yuan; S. Zhamkochyan; L. Zhu

2013-01-16T23:59:59.000Z

140

Geographic information system for Long Island: An epidemiologic systems approach to identify environmental breast cancer risks on Long Island. Phase 1  

SciTech Connect (OSTI)

BNL is developing and implementing the project ``Geographic Information System (GIS) for Long Island`` to address the potential relationship of environmental and occupational exposures to breast cancer etiology on Long Island. The project is divided into two major phases: The four month-feasibility project (Phase 1), and the major development and implementation project (Phase 2). This report summarizes the work completed in the four month Phase 1 Project, ``Feasibility of a Geographic Information System for Long Island.`` It provides the baseline information needed to further define and prioritize the scope of work for subsequent tasks. Phase 2 will build upon this foundation to develop an operational GIS for the Long Island Breast Cancer Study Project (LIBCSP).

Barancik, J.I.; Kramer, C.F.; Thode, H.C. Jr.

1995-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Risk Assessment of Diesel-Fired  

E-Print Network [OSTI]

65 20 3.4 Direct Mortality Risk 21 3.5 Ambient PM10 Concentrations 21 4.0 Low Wind Speed (Calm Risk Zones Table 2-7: Emission Factor Sensitivity Analysis Appendix 3: Low Wind Speed (Calm) Conditions Cancer Risk Spreadsheet 4-2: PM Mortality Table 4-3: Engine Size Distribution Table 4-4: Permitted vs

Mlllet, Dylan B.

142

DYNAMIC ILM AN APPROACH TO INFRARED-CAMERA BASED DYNAMICAL LIFETIME IMAGING  

E-Print Network [OSTI]

measurements in measurement times as fast as 1 sec per wafer. Keywords: carrier lifetime, imaging, thermography

143

Models for Battery Reliability and Lifetime: Applications in Design and Health Management (Presentation)  

SciTech Connect (OSTI)

This presentation discusses models for battery reliability and lifetime and the Battery Ownership Model.

Smith, K.; Neubauer, J.; Wood, E.; Jun, M.; Pesaran, A.

2013-06-01T23:59:59.000Z

144

Risk assessment of soil-based exposures to plutonium at experimental sites located on the Nevada Test Site and adjoining areas  

SciTech Connect (OSTI)

In the late 1950s and early 1960s, a series of tests was conducted at or near the Nevada Test Site to study issues involving plutonium-bearing devices. These tests resulted in the dispersal of about 5 TBq of {sup 239,240}Pu on the surficial soils at the test locations. Access to the sites is strictly controlled; therefore, it does not constitute a threat to human health at the present time. However, because the residual {sup 239} Pu decays slowly (half-life of 24,110 y), the sites could indeed represent a long-term hazard if they are not remediated and if institutional controls are lost. To investigate the magnitude of the potential health risks for this no-remediation case, we defined three basic exposure scenarios that could bring individuals in contact with {sup 239,240}Pu at the sites: (1) a resident living in a subdivision located at a test site, (2) a resident farmer, and (3) a worker at a commercial facility. Our screening analyses indicated that doses to organs are dominated by the intemal deposition of Pu via the inhalation pathway, and thus our risk assessment focused on those factors that affect inhalation exposures and associated doses, including inhalation rates, activity patterns, tenure at a residence or occupation, indoor/outdoor air relationships, and resuspension outdoors. Cancer risks were calculated as a function of lifetime cumulative doses to the key target organs (i.e., bone surface, liver, and lungs) and risk factors for those organs. Uncertainties in the predicted cancer risks were analyzed using Monte-Carlo simulations of the probability distributions used to represent assessment parameters. The principal sources of uncertainty in the estimated risks were population mobility, the relationship between indoor and outdoor contaminant levels, and the dose and risk factors for bone, liver, and lung.

Layton, D.W.; Anspaugh, L.R.; Bogen, K.T.; Straume, T.

1993-06-01T23:59:59.000Z

145

"Skin Cancer-What to Look For" Rochester Recreation  

E-Print Network [OSTI]

"Skin Cancer- What to Look For" Rochester Recreation Club for the Deaf May 20, 2010 #12;Supporters for the Deaf ("REAP") #12;Overview Skin Overview What is skin cancer? Who is at risk? How common is skin cancer? Signs of skin cancer Prevention Treatments #12;Skin Overview Skin is the largest organ in your body

Goldman, Steven A.

146

Thyroid cancer around Chernobyl  

SciTech Connect (OSTI)

The author`s presentation on thyroid cancer around Chernobyl will focus on four different things. First will be the time trends, or the pattern of thyroid cancer occurrence before and after the accident. It is now very well known that the increase in thyroid cancer in children in several areas has been unprecedented. Second, the author discusses thyroid cancer in general and patterns of thyroid cancer around the world before the Chernobyl accident, including differences by age and pathology. Third, the author presents relatively crude analyses of risk according to dose to the thyroid gland. And last, the author attempts to contrast the findings for thyroid cancer in relation to the internal radioiodine dose in Chernobyl studies with analyses of the effects of external dose on thyroid cancer incidence. The bottom line to be developed is similar to that presented by Elaine Ron with regard to effects of external dose on thyroid cancer. The similarities between the childhood finding from Chernobyl studies and external radiation studies appear more remarkable than the differences.

Beral, V. [Univ. of Oxford (United Kingdom)

1997-03-01T23:59:59.000Z

147

Measurement of the KL meson lifetime with the KLOE detector  

E-Print Network [OSTI]

We present a measurement of the KL lifetime using the KLOE detector. From a sample of 4 x 10^8 KS KL pairs following the reaction e+ e- -> phi -> KS KL we select 15 x 10^6 KL -> p0 p0 p0 decays tagged by KS -> pi+ pi- events. From a fit of the proper time distribution we find tau_L = (50.92 +- 0.17{stat} +- 0.25{syst})$ ns. This is the most precise measurement of the KL lifetime performed to date.

The KLOE collaboration

2005-10-17T23:59:59.000Z

148

Infrared-Active Heterostructured Nanocrystals with Ultralong Carrier Lifetimes  

SciTech Connect (OSTI)

We present the synthesis of composite PbSe/CdSe/CdS nanocrystals with two distinct geometries: core/shell/shell structures and tetrapods. These novel nanostructures exhibit extremely long carrier decay times up to 20 ?s that are combined with high emission efficiencies in the infrared. The increase in carrier lifetimes is attributed to the reduction of the electron?hole overlap as a result of delocalization of the electron wave function into the outer CdS shell or arms. The ultralong carrier lifetimes and controlled geometry render these nanocrystals attractive for a variety of applications from lasing to photocatalysis and photovoltaics.

Lee, Doh C.; Robel, Istvan; Pietryga, Jeffrey M.; Klimov, Victor I.

2010-01-01T23:59:59.000Z

149

doi:10.1016/j.ijrobp.2006.02.044 INDUCED SECOND CANCERS AFTER PROSTATE-CANCER  

E-Print Network [OSTI]

doi:10.1016/j.ijrobp.2006.02.044 EDITORIAL INDUCED SECOND CANCERS AFTER PROSTATE-CANCER University Medical Center, New York, NY The absolute risks of a radiation-induced second cancer among long concern, expressed by Kendal et al. (5) in this issue, that prostate cancer patients may be unduly

Brenner, David Jonathan

150

Diabetes and breast cancer : the women's healthy eating & living study  

E-Print Network [OSTI]

and their effects on diabetes risk, randomized controlledQiao Q, Zethelius B, et al: Diabetes, prediabetes and cancerS, Lopez A, et al: Diabetes, obesity and survival in a large

Erickson, Kirsten Diann

2011-01-01T23:59:59.000Z

151

Polymer Electrolyte Fuel Cell Lifetime Limitations: The Role of  

E-Print Network [OSTI]

conditions, load profiles, and type of electrocatalyst on the performance degradation, and ­ Determine-Horn ­ Massachusetts Institute of Technology Paulo Ferreira ­ University of Texas at Austin Dane Morgan ­ University systems to achieve the DOE lifetime targets. Technical Targets ­ Durability with cycling 5,000 hours (

152

Lifetime Prediction for Supercapacitor-powered Wireless Sensor Nodes  

E-Print Network [OSTI]

Lifetime Prediction for Supercapacitor-powered Wireless Sensor Nodes Christian Renner, J step towards reaching this goal: It explores discharging-characteristics of supercapacitors, discusses-ion polymers, supercapacitors can last for 10 years or even more. Superca- pacitors do not need a complex

Turau, Volker

153

Design of the Muon Lifetime Experiment By Steve Kliewer  

E-Print Network [OSTI]

the lifetime of the Muon particle. This planned device will use 4, low voltage, classroom safe scintillator detectors and a data acquisition electronics board developed by Quarknet of FermiLab. Analysis, low voltage, classroom safe, detectors 2. DAQ: use the electronics developed by Quarknet (QNET2) 3

California at Santa Cruz, University of

154

MAJOR, LIFETIME ACHIEVEMENT AWARD FOR POET, PROF. PAUL MARIANI  

E-Print Network [OSTI]

MAJOR, LIFETIME ACHIEVEMENT AWARD FOR POET, PROF. PAUL MARIANI CHESTNUT HILL, MA (February 2009) -- University Prof. of English Paul Mariani, a noted Catholic poet and essayist who is one of America's foremost regarded biographies of twentieth-century American poets": William Carlos Williams: A New World Naked (1981

Huang, Jianyu

155

Precision Measurement of the ?[0 over b] Baryon Lifetime  

E-Print Network [OSTI]

The ratio of the ?[0 over b] baryon lifetime to that of the B?[superscript 0] meson is measured using 1.0??fb[superscript -1] of integrated luminosity in 7 TeV center-of-mass energy pp collisions at the LHC. The ?[0 over ...

Williams, Michael

156

Precision measurement of the Lambda_b baryon lifetime  

E-Print Network [OSTI]

The ratio of the \\Lambda b baryon lifetime to that of the B0 meson is measured using 1.0/fb of integrated luminosity in 7 TeV center-of-mass energy pp collisions at the LHC. The \\Lambda b baryon is observed for the first time in the decay mode \\Lambda b -> J/\\psi pK-, while the B0 meson decay used is the well known B0 -> J/\\psi pi+K- mode, where the pi+ K- mass is consistent with that of the K*0(892) meson. The ratio of lifetimes is measured to be 0.976 +/- 0.012 +/- 0.006, in agreement with theoretical expectations based on the heavy quark expansion. Using previous determinations of the B0 meson lifetime, the \\Lambda b lifetime is found to be 1.482 +/- 0.018 +/- 0.012 ps. In both cases the first uncertainty is statistical and the second systematic.

LHCb collaboration; R. Aaij; B. Adeva; M. Adinolfi; C. Adrover; A. Affolder; Z. Ajaltouni; J. Albrecht; F. Alessio; M. Alexander; S. Ali; G. Alkhazov; P. Alvarez Cartelle; A. A. Alves Jr; S. Amato; S. Amerio; Y. Amhis; L. Anderlini; J. Anderson; R. Andreassen; J. E. Andrews; R. B. Appleby; O. Aquines Gutierrez; F. Archilli; A. Artamonov; M. Artuso; E. Aslanides; G. Auriemma; M. Baalouch; S. Bachmann; J. J. Back; C. Baesso; V. Balagura; W. Baldini; R. J. Barlow; C. Barschel; S. Barsuk; W. Barter; Th. Bauer; A. Bay; J. Beddow; F. Bedeschi; I. Bediaga; S. Belogurov; K. Belous; I. Belyaev; E. Ben-Haim; G. Bencivenni; S. Benson; J. Benton; A. Berezhnoy; R. Bernet; M. -O. Bettler; M. van Beuzekom; A. Bien; S. Bifani; T. Bird; A. Bizzeti; P. M. Bj\\ornstad; T. Blake; F. Blanc; J. Blouw; S. Blusk; V. Bocci; A. Bondar; N. Bondar; W. Bonivento; S. Borghi; A. Borgia; T. J. V. Bowcock; E. Bowen; C. Bozzi; T. Brambach; J. van den Brand; J. Bressieux; D. Brett; M. Britsch; T. Britton; N. H. Brook; H. Brown; I. Burducea; A. Bursche; G. Busetto; J. Buytaert; S. Cadeddu; O. Callot; M. Calvi; M. Calvo Gomez; A. Camboni; P. Campana; D. Campora Perez; A. Carbone; G. Carboni; R. Cardinale; A. Cardini; H. Carranza-Mejia; L. Carson; K. Carvalho Akiba; G. Casse; L. Castillo Garcia; M. Cattaneo; Ch. Cauet; R. Cenci; M. Charles; Ph. Charpentier; P. Chen; N. Chiapolini; M. Chrzaszcz; K. Ciba; X. Cid Vidal; G. Ciezarek; P. E. L. Clarke; M. Clemencic; H. V. Cliff; J. Closier; C. Coca; V. Coco; J. Cogan; E. Cogneras; P. Collins; A. Comerma-Montells; A. Contu; A. Cook; M. Coombes; S. Coquereau; G. Corti; B. Couturier; G. A. Cowan; D. C. Craik; S. Cunliffe; R. Currie; C. D'Ambrosio; P. David; P. N. Y. David; A. Davis; I. De Bonis; K. De Bruyn; S. De Capua; M. De Cian; J. M. De Miranda; L. De Paula; W. De Silva; P. De Simone; D. Decamp; M. Deckenhoff; L. Del Buono; N. Déléage; D. Derkach; O. Deschamps; F. Dettori; A. Di Canto; H. Dijkstra; M. Dogaru; S. Donleavy; F. Dordei; A. Dosil Suárez; D. Dossett; A. Dovbnya; F. Dupertuis; P. Durante; R. Dzhelyadin; A. Dziurda; A. Dzyuba; S. Easo; U. Egede; V. Egorychev; S. Eidelman; D. van Eijk; S. Eisenhardt; U. Eitschberger; R. Ekelhof; L. Eklund; I. El Rifai; Ch. Elsasser; A. Falabella; C. Färber; G. Fardell; C. Farinelli; S. Farry; D. Ferguson; V. Fernandez Albor; F. Ferreira Rodrigues; M. Ferro-Luzzi; S. Filippov; M. Fiore; C. Fitzpatrick; M. Fontana; F. Fontanelli; R. Forty; O. Francisco; M. Frank; C. Frei; M. Frosini; S. Furcas; E. Furfaro; A. Gallas Torreira; D. Galli; M. Gandelman; P. Gandini; Y. Gao; J. Garofoli; P. Garosi; J. Garra Tico; L. Garrido; C. Gaspar; R. Gauld; E. Gersabeck; M. Gersabeck; T. Gershon; Ph. Ghez; V. Gibson; L. Giubega; V. V. Gligorov; C. Göbel; D. Golubkov; A. Golutvin; A. Gomes; P. Gorbounov; H. Gordon; M. Grabalosa Gándara; R. Graciani Diaz; L. A. Granado Cardoso; E. Graugés; G. Graziani; A. Grecu; E. Greening; S. Gregson; P. Griffith; O. Grünberg; B. Gui; E. Gushchin; Yu. Guz; T. Gys; C. Hadjivasiliou; G. Haefeli; C. Haen; S. C. Haines; S. Hall; B. Hamilton; T. Hampson; S. Hansmann-Menzemer; N. Harnew; S. T. Harnew; J. Harrison; T. Hartmann; J. He; T. Head; V. Heijne; K. Hennessy; P. Henrard; J. A. Hernando Morata; E. van Herwijnen; A. Hicheur; E. Hicks; D. Hill; M. Hoballah; C. Hombach; P. Hopchev; W. Hulsbergen; P. Hunt; T. Huse; N. Hussain; D. Hutchcroft; D. Hynds; V. Iakovenko; M. Idzik; P. Ilten; R. Jacobsson; A. Jaeger; E. Jans; P. Jaton; A. Jawahery; F. Jing; M. John; D. Johnson; C. R. Jones; C. Joram; B. Jost; M. Kaballo; S. Kandybei; W. Kanso; M. Karacson; T. M. Karbach; I. R. Kenyon; T. Ketel; A. Keune; B. Khanji; O. Kochebina; I. Komarov; R. F. Koopman; P. Koppenburg; M. Korolev; A. Kozlinskiy; L. Kravchuk; K. Kreplin; M. Kreps; G. Krocker; P. Krokovny; F. Kruse; M. Kucharczyk; V. Kudryavtsev; T. Kvaratskheliya; V. N. La Thi; D. Lacarrere; G. Lafferty; A. Lai; D. Lambert; R. W. Lambert; E. Lanciotti; G. Lanfranchi; C. Langenbruch; T. Latham; C. Lazzeroni; R. Le Gac; J. van Leerdam; J. -P. Lees; R. Lefèvre; A. Leflat; J. Lefrançois; S. Leo; O. Leroy; T. Lesiak; B. Leverington; Y. Li; L. Li Gioi; M. Liles; R. Lindner; C. Linn; B. Liu; G. Liu; S. Lohn; I. Longstaff; J. H. Lopes; N. Lopez-March; H. Lu; D. Lucchesi; J. Luisier; H. Luo; F. Machefert; I. V. Machikhiliyan; F. Maciuc; O. Maev; S. Malde; G. Manca; G. Mancinelli; J. Maratas; U. Marconi; P. Marino; R. Märki; J. Marks; G. Martellotti; A. Martens; A. Martín Sánchez; M. Martinelli; D. Martinez Santos; D. Martins Tostes; A. Massafferri; R. Matev; Z. Mathe; C. Matteuzzi; E. Maurice; A. Mazurov; B. Mc Skelly; J. McCarthy; A. McNab; R. McNulty; B. Meadows; F. Meier; M. Meissner; M. Merk; D. A. Milanes; M. -N. Minard; J. Molina Rodriguez; S. Monteil; D. Moran; P. Morawski; A. Mordà; M. J. Morello; R. Mountain; I. Mous; F. Muheim; K. Müller; R. Muresan

2013-07-31T23:59:59.000Z

157

Detection of Atherosclerotic Coronary Plaques by Fluorescence Lifetime Imaging Angioscopy  

E-Print Network [OSTI]

and sliced open to have their lumens imaged. For each sample, 51 time resolved wide-field images were taken over 10 nanoseconds at 390 (±40) nm, 450 (±40) nm, and 550 (±88) nm wavelengths. To analyze the samples, the intensity map and lifetime map were...

Thomas, Patrick A.

2010-10-12T23:59:59.000Z

158

AIAA-2001-0025 SPECTRUM FATIGUE LIFETIME AND RESIDUAL STRENGTH  

E-Print Network [OSTI]

on a typical fiberglass laminate configuration turbine blade fiberglass material has been undertaken under at various fractions of the lifetime turbine blade materials.. are consistent with the residual strength of fiberglass spectrum have been studied. Data have been obtained for materials produce results that may

159

A Treatment Planning and Acute Toxicity Comparison of Two Pelvic Nodal Volume Delineation Techniques and Delivery Comparison of Intensity-Modulated Radiotherapy Versus Volumetric Modulated Arc Therapy for Hypofractionated High-Risk Prostate Cancer Radiotherapy  

SciTech Connect (OSTI)

Purpose: To perform a comparison of two pelvic lymph node volume delineation strategies used in intensity-modulated radiotherapy (IMRT) for high risk prostate cancer and to determine the role of volumetric modulated arc therapy (VMAT). Methods and Materials: Eighteen consecutive patients accrued to an ongoing clinical trial were identified according to either the nodal contouring strategy as described based on lymphotropic nanoparticle-enhanced magnetic resonance imaging technology (9 patients) or the current Radiation Therapy Oncology Group (RTOG) consensus guidelines (9 patients). Radiation consisted of 45 Gy to prostate, seminal vesicles, and lymph nodes, with a simultaneous integrated boost to the prostate alone, to a total dose of 67.5 Gy delivered in 25 fractions. Prospective acute genitourinary and gastrointestinal toxicities were compared at baseline, during radiotherapy, and 3 months after radiotherapy. Each patient was retrospectively replanned using the opposite method of nodal contouring, and plans were normalized for dosimetric comparison. VMAT plans were also generated according to the RTOG method for comparison. Results: RTOG plans resulted in a significantly lower rate of genitourinary frequency 3 months after treatment. The dosimetric comparison showed that the RTOG plans resulted in both favorable planning target volume (PTV) coverage and lower organs at risk (OARs) and integral (ID) doses. VMAT required two to three arcs to achieve adequate treatment plans, we did not observe consistent dosimetric benefits to either the PTV or the OARs, and a higher ID was observed. However, treatment times were significantly shorter with VMAT. Conclusion: The RTOG guidelines for pelvic nodal volume delineation results in favorable dosimetry and acceptable acute toxicities for both the target and OARs. We are unable to conclude that VMAT provides a benefit compared with IMRT.

Myrehaug, Sten [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada); Chan, Gordon [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Craig, Tim [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada); Weinberg, Vivian [Biostatistics Core, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA (United States); Cheng, Chun [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Roach, Mack [Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (United States); Cheung, Patrick [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Sahgal, Arjun, E-mail: arjun.sahgal@sunnybrook.ca [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada)

2012-03-15T23:59:59.000Z

160

AmericanLungAssociationStateofLungDiseaseinDiverseCommunities2010 55 Lung Cancer  

E-Print Network [OSTI]

AmericanLungAssociationStateofLungDiseaseinDiverseCommunities2010 55 Lung Cancer Lung cancer of cancer cells (tumors) then form and grow . Besides interfering with how the lung functions, cancer cells organs . Causes Cigarette smoking is by far the most important cause of lung cancer, and the risk from

Kaski, Samuel

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Risk of Subclinical Micrometastatic Disease in the Supraclavicular Nodal Bed According to the Anatomic Distribution in Patients With Advanced Breast Cancer  

SciTech Connect (OSTI)

Purpose: To determine the anatomic distribution of gross supraclavicular nodes within the supraclavicular fossa using 2-deoxy-2-[F-18] fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) scans, and to evaluate likely coverage of specific regions of the supraclavicular fossa using standard radiation fields. Methods and Materials: We identified 33 patients with advanced or metastatic breast cancer who had a PET/CT scan demonstrating hypermetabolic supraclavicular lymph nodes in 2005. The locations of the involved lymph nodes were mapped onto a single CT set of images of the supraclavicular fossa. These lymph nodes were also mapped onto the treatment-planning CT dataset of 4 patients treated in our institution (2 patients with biopsy-proven supraclavicular nodes and 2 patients with clinically negative supraclavicular nodes). Results: We were able to determine the distribution of 52 supraclavicular lymph nodes in 32 patients. Of 32 patients, 28 (87%) had a history of metastatic disease, and 2 patients had isolated nodal recurrences. Five patients had supraclavicular nodes posterior to the vertebral body transverse process, and several lymph nodes were in close proximity to the medial field border, raising the possibility of geographic miss in these areas. Conclusions: In patients with locally advanced disease, increased coverage of the supraclavicular fossa medially and posteriorly may be warranted.

Reed, Valerie K. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Cavalcanti, Jose L. [Department of Nuclear Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Strom, Eric A.; Perkins, George H.; Oh, Julia L.; Tereffe, Welela; Yu, T.-K. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Yeung, Henry [Department of Nuclear Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Whitman, Gary J. [Department of Diagnostic Imaging, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Bedrosian, Isabelle [Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Macapinlac, Homer A. [Department of Nuclear Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Buchholz, Thomas A. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Woodward, Wendy A. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)], E-mail: wwoodward@mdanderson.org

2008-06-01T23:59:59.000Z

162

aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Lung cancer Lung cancer Lung cancer Lung c  

E-Print Network [OSTI]

--22000000 34 Lung cancer Lung cancer Lung cancer Lung c ancer Lung cancer Lung cancer Lung cancer L ung cancer Lung cancer Lung cancer Lung can cer Lung cancer Lung cancer Lung cancer Lun g cancer Lung cancer Lung cancer Lung cance r Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer

Paxton, Anthony T.

163

United States Environmental Protection Agency: Use of risk assessment and risk management methodologies. Master's thesis  

SciTech Connect (OSTI)

Make a full investigation of the policy implications and appropriate uses of risk assessment and risk management in regulatory programs under various Federal laws to prevent cancer and other chronic health effects which may result from exposure to hazardous substances. This is the primary mission of the Risk Assessment and Management Commission (Risk Commission). The Clean Air Act Amendments of 1990 (CAAA), created the Risk Commission reflecting Congress' concern over agency use of risk assessment and risk management techniques and methodologies to implement federal laws protective of human health. The Risk Commission is to consider: methods for measuring and describing risks of chronic health effects from hazardous substances; methods to reflect uncertainties associated with estimation techniques, and whether it is possible or desirable to develop a consistent risk assessment methodology or a consistent standard of acceptable risk for various federal programs.

Lamuro, R.J.

1992-09-30T23:59:59.000Z

164

E-Print Network 3.0 - accurate lifetime measurements Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Science 45 Measurements of the mean lifetime and kinetic-energy release of metastable CO2 J. P. Bouhnik,* I. Gertner, and B. Rosner Summary: Measurements of the mean lifetime...

165

UIUC Collector Erosion and Optical Lifetime Project Results: Time Dependent Exposures  

E-Print Network [OSTI]

UIUC Collector Erosion and Optical Lifetime Project Results: Time Dependent Exposures Darren A is the lifetime of collector optics. Frequent replacement of the mirror system will detract from the economic

Spila, Timothy P.

166

Apparatus for measuring minority carrier lifetimes in semiconductor materials  

DOE Patents [OSTI]

An apparatus for determining the minority carrier lifetime of a semiconductor sample includes a positioner for moving the sample relative to a coil. The coil is connected to a bridge circuit such that the impedance of one arm of the bridge circuit is varied as sample is positioned relative to the coil. The sample is positioned relative to the coil such that any change in the photoconductance of the sample created by illumination of the sample creates a linearly related change in the input impedance of the bridge circuit. In addition, the apparatus is calibrated to work at a fixed frequency so that the apparatus maintains a consistently high sensitivity and high linearly for samples of different sizes, shapes, and material properties. When a light source illuminates the sample, the impedance of the bridge circuit is altered as excess carriers are generated in the sample, thereby producing a measurable signal indicative of the minority carrier lifetimes or recombination rates of the sample.

Ahrenkiel, Richard K. (Lakewood, CO)

1999-01-01T23:59:59.000Z

167

Orientation-Dependent Entanglement Lifetime in a Squeezed Atomic Clock  

SciTech Connect (OSTI)

We study experimentally the application of a class of entangled states, squeezed spin states, to the improvement of atomic-clock precision. In the presence of anisotropic noise, the entanglement lifetime is strongly dependent on squeezing orientation. We measure the Allan deviation spectrum of a clock operated with a phase-squeezed input state. For averaging times up to 50 s the squeezed clock achieves a given precision 2.8(3) times faster than a clock operating at the standard quantum limit.

Leroux, Ian D.; Schleier-Smith, Monika H.; Vuletic, Vladan [Department of Physics, MIT-Harvard Center for Ultracold Atoms and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

2010-06-25T23:59:59.000Z

168

Detection of counterfeit U.S. paper money using intrinsic fluorescence lifetime  

E-Print Network [OSTI]

-photon spectral and lifetime fluorescence microscopy," Appl. Opt. 43(27), 5173­5182 (2004). #118121 - $15.00 USD

Levene, Michael J.

169

Predictive Models of Li-ion Battery Lifetime (Presentation)  

SciTech Connect (OSTI)

Predictive models of Li-ion battery reliability must consider a multiplicity of electrochemical, thermal and mechanical degradation modes experienced by batteries in application environments. Complicating matters, Li-ion batteries can experience several path dependent degradation trajectories dependent on storage and cycling history of the application environment. Rates of degradation are controlled by factors such as temperature history, electrochemical operating window, and charge/discharge rate. Lacking accurate models and tests, lifetime uncertainty must be absorbed by overdesign and warranty costs. Degradation models are needed that predict lifetime more accurately and with less test data. Models should also provide engineering feedback for next generation battery designs. This presentation reviews both multi-dimensional physical models and simpler, lumped surrogate models of battery electrochemical and mechanical degradation. Models are compared with cell- and pack-level aging data from commercial Li-ion chemistries. The analysis elucidates the relative importance of electrochemical and mechanical stress-induced degradation mechanisms in real-world operating environments. Opportunities for extending the lifetime of commercial battery systems are explored.

Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G.; Shi, Y.; Pesaran, A.

2014-09-01T23:59:59.000Z

170

NEUTRON LIFETIME EXPERIMENT USING UCN STORAGE IN AN `ACCORDION-LIKE' TRAP  

E-Print Network [OSTI]

NEUTRON LIFETIME EXPERIMENT USING UCN STORAGE IN AN `ACCORDION-LIKE' TRAP BY ASHISH M. DESAI determination of the neutron lifetime has an impact on particle physics and cosmology. We report progress towards a measurement of the neutron lifetime using an accordion-like storage trap. Ultracold neutrons

Steyerl, Albert

171

Dosimetric Comparison of Intensity-Modulated Radiotherapy Plans, With or Without Anterior Myocardial Territory and Left Ventricle as Organs at Risk, in Early-Stage Left-Sided Breast Cancer Patients  

SciTech Connect (OSTI)

Purpose: We evaluated heart sparing using an intensity-modulated radiotherapy (IMRT) plan with the left ventricle (LV) and/or the anterior myocardial territory (AMT) as additional organs at risk (OARs). Methods and Materials: A total of 10 patients with left-sided breast cancer were selected for dosimetric planning. Both lungs, the right breast, heart, LV, and AMT were defined as OARs. We generated one tangential field plan and four IMRT plans for each patient. We examined the dose-volume histogram parameters of the planning target volume and OARs. Results: Compared with the tangential field plan, the mean dose to the heart in the IMRT plans did not show significant differences; however, the dose to the AMT and LV decreased by 18.7-45.4% and 10.8-37.4%, respectively. The maximal dose to the heart decreased by 18.6-35.3%, to the AMT by 22.0-45.1%, and to the LV by 23.5-45.0%, And the relative volumes of the heart (V{sub {>=}12}), AMT (V{sub >11}) and LV (V{sub >10}) decreased significantly with different levels, respectively. The volume of the heart, AMT, LV, both lungs, and right breast receiving {>=}5 Gy showed a significant increase. Compared with the IMRT (H) plan, the mean dose to the heart, AMT, and LV decreased by 17.5-21.5%, 25.2-29.8%, and 22.8-29.8% and the maximal dose by 13.6-20.6%, 23.1-29.6%, and 17.3-29.1%, respectively. The IMRT plans for both lungs and the right breast showed no significant differences. Conclusions: The IMRT plans with the addition of the AMT and/or LV as OARs considerably increased heart sparing. We recommend including the LV as an additional OAR in such plans.

Tan Wenyong [Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology College of Life Science and Technology, Wuhan (China); Wang Xiaohong; Qiu Dasheng [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Liu Dong [Department of Radiology, Hubei Cancer Hospital, Wuhan (China); Jia Shaohui; Zeng Fanyu [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Chen Zhengwang [Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology College of Life Science and Technology, Wuhan (China); Li Beihui; Xu Jiaozhen; Wei Lai [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China); Hu Desheng, E-mail: tanwyym@yahoo.com.cn [Department of Radiotherapy, Hubei Cancer Hospital, Wuhan (China)

2011-12-01T23:59:59.000Z

172

Silicon avalanche photodiode operation and lifetime analysis for small satellites  

E-Print Network [OSTI]

Silicon avalanche photodiodes (APDs) are sensitive to operating temperature fluctuations and are also susceptible to radiation flux expected in satellite-based quantum experiments. We introduce a low power voltage adjusting mechanism to overcome the effects of in-orbit temperature fluctuations. We also present data on the performance of Si APDs after irradiation (gamma-ray and proton beam). Combined with an analysis of expected orbital irradiation, we propose that a Si APD in a 400 km equatorial orbit may operate beyond the lifetime of the satellite.

Tan, Yue Chuan; Cheng, Cliff; Ling, Alexander

2013-01-01T23:59:59.000Z

173

Silicon avalanche photodiode operation and lifetime analysis for small satellites  

E-Print Network [OSTI]

Silicon avalanche photodiodes (APDs) are sensitive to operating temperature fluctuations and are also susceptible to radiation flux expected in satellite-based quantum experiments. We introduce a low power voltage adjusting mechanism to overcome the effects of in-orbit temperature fluctuations. We also present data on the performance of Si APDs after irradiation (gamma-ray and proton beam). Combined with an analysis of expected orbital irradiation, we propose that a Si APD in a 400 km equatorial orbit may operate beyond the lifetime of the satellite.

Yue Chuan Tan; Rakhitha Chandrasekara; Cliff Cheng; Alexander Ling

2013-06-28T23:59:59.000Z

174

Lifetime of 981-Kev State in Li-8  

E-Print Network [OSTI]

V y-ray transition observed at 0' to the beam axis was expected to be shifted upward in energy to 1017 keV (unattenuated shift). Since the lifetime was known to be much shorter than the slowing-down times typically obtainable with solid materials... target (full shift ?no significant slowing down of the recoiling nucleus before decay) and the energy of the Doppler- shifted y ray for a solid target (attenuated shift? target material chosen to maximize the slowing- down time). The attenuated...

Throop, M. J.; Youngblood, David H.; Morrison, G. C.

1971-01-01T23:59:59.000Z

175

Nanoscale fluorescence lifetime imaging with a single diamond NV center  

E-Print Network [OSTI]

Solid-state quantum emitters, such as artificially engineered quantum dots or naturally occurring defects in solids, are being investigated for applications ranging from quantum information science and optoelectronics to biomedical imaging. Recently, these same systems have also been studied from the perspective of nanoscale metrology. In this letter we study the near-field optical properties of a diamond nanocrystal hosting a single nitrogen vacancy center. We find that the nitrogen vacancy center is a sensitive probe of the surrounding electromagnetic mode structure. We exploit this sensitivity to demonstrate nanoscale fluorescence lifetime imaging microscopy (FLIM) with a single nitrogen vacancy center by imaging the local density of states of an optical antenna.

Ryan Beams; Dallas Smith; Timothy W. Johnson; Sang-Hyun Oh; Lukas Novotny; Nick Vamivakas

2013-03-05T23:59:59.000Z

176

Lifetimes of negative parity states in {sup 168}Er  

SciTech Connect (OSTI)

Using the GRID method the lifetimes of 12 states belonging to four negative parity bands in {sup 168}Er were measured at the high flux reactor of the Institut Laue-Langevin (ILL). For K{sup {pi}}=0{sub 1}{sup -} and K{sup {pi}}=2{sub 1}{sup -} bands the absolute E1 transitions are in agreement with those obtained within the framework of the sdf IBA-1 model and their octupole vibrational character is confirmed. (c) 2000 The American Physical Society.

Genilloud, L. [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland)] [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland); Jolie, J. [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland)] [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland); Boerner, H. G. [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France)] [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France); Lehmann, H. [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France)] [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France); Becvar, F. [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic)] [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic); Krticka, M. [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic)] [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic); Zamfir, N. V. [WNSL, Yale University, New Haven, Connecticut 06520 (United States) [WNSL, Yale University, New Haven, Connecticut 06520 (United States); Clark University, Worcester, Massachusetts 01610 (United States); Casten, R. F. [WNSL, Yale University, New Haven, Connecticut 06520 (United States)] [WNSL, Yale University, New Haven, Connecticut 06520 (United States)

2000-09-01T23:59:59.000Z

177

Positron lifetime spectrometer using a DC positron beam  

DOE Patents [OSTI]

An entrance grid is positioned in the incident beam path of a DC beam positron lifetime spectrometer. The electrical potential difference between the sample and the entrance grid provides simultaneous acceleration of both the primary positrons and the secondary electrons. The result is a reduction in the time spread induced by the energy distribution of the secondary electrons. In addition, the sample, sample holder, entrance grid, and entrance face of the multichannel plate electron detector assembly are made parallel to each other, and are arranged at a tilt angle to the axis of the positron beam to effectively separate the path of the secondary electrons from the path of the incident positrons.

Xu, Jun; Moxom, Jeremy

2003-10-21T23:59:59.000Z

178

Sandia National Laboratories: acceler-ated lifetime test  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1development Sandia, NREL Release Wave EnergyLinksZ News Dry-runacceler-ated lifetime

179

A simulation model for the lifetime of wireless sensor networks  

E-Print Network [OSTI]

In this paper we present a model for the lifetime of wireless sensor networks. The model takes into consideration several parameters such as the total number of sensors, network size, percentage of sink nodes, location of sensors, the mobility of sensors, and power consumption. A definition of the life time of the network based on three different criteria is introduced; percentage of available power to total power, percentage of alive sensors to total sensors, and percentage of alive sink sensors to total sink sensors. A Matlab based simulator is developed for the introduced model. A number of wireless sensor networks scenarios are presented and discussed.

Elleithy, Abdelrahman

2012-01-01T23:59:59.000Z

180

Body Weight Status, Inflammation, and Prognostic Markers in Early-Stage Prostate Cancer  

E-Print Network [OSTI]

Body Weight Status, Inflammation, and Prognostic Markers in Early-Stage Prostate Cancer Brown Bag (UICCC) IHRP Fellow #12;Outline Relative risk of cancer mortality in obese men Pathophysiologic basis for excess risk The case for inflammation/immunity in prostate cancer Preliminary results from

Illinois at Chicago, University of

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Genetic Susceptibility and Survival: Application to Breast Cancer  

E-Print Network [OSTI]

Genetic Susceptibility and Survival: Application to Breast Cancer Edwin S. IVERSEN, JR., Giovanni are known to confer an elevated risk of both breast and ovarian cancers. The effect of carrying such a mutation on survival after developing breast or ovarian cancer is less well understood. We investigate

West, Mike

182

Some problems of steam turbine lifetime assessment and extension  

SciTech Connect (OSTI)

The problems of lifetime assessment and extension in reference to power equipment (including high-temperature rotors and casings of power steam turbines) and theoretical and normative grounds for these procedures, as well as some specific measures to prolong the turbine service time and diagnose the turbine components` conditions in the operation process, were covered in many published works, including the authors` ones. The present paper is to consider in more details some aspects of these problems that have not been sufficiently considered in known publications. In particular, it seems important to dwell on experimental verification of some mathematical models for calculating temperatures, stresses, and strains in the turbine casings on the basis of direct measurements at turbines in service. Another item to be discussed ia an approach to choosing the system of interrelated criteria and safety factors referring to the upper admissible values of stresses, strains, cycles, and accumulated damage, as well as crack resistance, as applied to an adopted conception of the limiting states for the rotors and casings with taking into consideration their loads and resulted stress-strain states. In this connection, it is important to arrange and use properly the continuous monitoring of temperatures, stresses, and accumulated metal damage to assess the residual lifetime of the rotors and casings more accurately. Certain design, technology, and repair measures are briefly described. They have successfully been employed at fossil power plants of the former Soviet Union to raise the steam turbine reliability and durability.

Berlyand, V.; Pozhidaev, A.; Glyadya, A. [Kharkov Central Designers Bureau (Ukraine); Plotkin, E.; Avrutsky, G. [All-Russia Thermal Engineering Research Inst., Moscow (Russian Federation); Leyzerovich, A. [Actinium Corp., Mountain View, CA (United States)

1999-11-01T23:59:59.000Z

183

Apparatus for measuring minority carrier lifetimes in semiconductor materials  

DOE Patents [OSTI]

An apparatus for determining the minority carrier lifetime of a semiconductor sample includes a positioner for moving the sample relative to a coil. The coil is connected to a bridge circuit such that the impedance of one arm of the bridge circuit is varied as sample is positioned relative to the coil. The sample is positioned relative to the coil such that any change in the photoconductance of the sample created by illumination of the sample creates a linearly related change in the input impedance of the bridge circuit. In addition, the apparatus is calibrated to work at a fixed frequency so that the apparatus maintains a consistently high sensitivity and high linearly for samples of different sizes, shapes, and material properties. When a light source illuminates the sample, the impedance of the bridge circuit is altered as excess carriers are generated in the sample, thereby producing a measurable signal indicative of the minority carrier lifetimes or recombination rates of the sample. 17 figs.

Ahrenkiel, R.K.

1999-07-27T23:59:59.000Z

184

The Differential Lifetimes of Protostellar Gas and Dust Disks  

E-Print Network [OSTI]

We construct a protostellar disk model that takes into account the combined effect of viscous evolution, photoevaporation and the differential radial motion of dust grains and gas. For T Tauri disks, the lifetimes of dust disks that are mainly composed of millimeter sized grains are always shorter than the gas disks' lifetimes, and become similar only when the grains are fluffy (density 10 AU), without strong signs of gas accretion nor of millimeter thermal emission from the dust. For Herbig AeBe stars, the strong photoevaporation clears the inner disks in 10^6 yr, before the dust grains in the outer disk migrate to the inner region. In this case, the grains left behind in the outer gas disk accumulate at the disk inner edge (at 10-100 AU from the star). The dust grains remain there even after the entire gas disk has been photoevaporated, and form a gas-poor dust ring similar to that observed around HR 4796A. Hence, depending on the strength of the stellar ionizing flux, our model predicts opposite types of products around young stars. For low mass stars with a low photoevaporation rate, dust-poor gas disks with an inner hole would form, whereas for high mass stars with a high photoevaporation rate, gas-poor dust rings would form. This prediction should be examined by observations of gas and dust around weak line T Tauri stars and evolved Herbig AeBe stars.

Taku Takeuchi; C. J. Clarke; D. N. C. Lin

2005-03-22T23:59:59.000Z

185

Extending the lifetime of fuel cell based hybrid systems  

E-Print Network [OSTI]

Fuel cells are clean power sources that have much higher energy densities and lifetimes compared to batteries. However, fuel cells have limited load following capabilities and cannot be efficiently utilized if used in isolation. In this work, we consider a hybrid system where a fuel cell based hybrid power source is used to provide power to a DVFS processor. The hybrid power source consists of a room temperature fuel cell operating as the primary power source and a Li-ion battery (that has good load following capability) operating as the secondary source. Our goal is to develop polices to extend the lifetime of the fuel cell based hybrid system. First, we develop a charge based optimization framework which minimizes the charge loss of the hybrid system (and not the energy consumption of the DVFS processor). Next, we propose a new algorithm to minimize the charge loss by judiciously scaling the load current. We compare the performance of this algorithm with one that has been optimized for energy, and demonstrate its superiority. Finally, we evaluate the performance of the hybrid system under different system configurations and show how to determine the best combination of fuel cell size and battery capacity for a given embedded application.

Jianli Zhuo; Chaitali Chakrabarti; Naehyuck Chang; Sarma Vrudhula

2006-01-01T23:59:59.000Z

186

Potential for Cardiovascular Exercise Dosing to Improve Cardiorespiratory Fitness in Breast Cancer Survivors  

E-Print Network [OSTI]

to investigating feasibility, we analyzed the potential for cardiovascular exercise dosing to have different effects on CVD and breast cancer risk factors including low VO2max and weight gain during an Energy Balance Program. Nineteen female breast cancer survivors...

Burnett, Dave

2013-05-31T23:59:59.000Z

187

Mechanisms of Action of Metformin as an Anti-cancer Agent  

E-Print Network [OSTI]

Cancer is the second leading cause of death worldwide and epidemiological studies suggest the association of diabetes mellitus with an enhanced risk for multiple cancers. Metformin (1,1-dimethylbiguanide hydrochloride) is the most widely prescribed...

Ramachandran Nair Vasanthakum, Vijayalekshmi

2014-08-13T23:59:59.000Z

188

E-Print Network 3.0 - assessing cancer stage Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer stage Search Powered by Explorit Topic List Advanced Search Sample search results for: assessing cancer stage Page: << < 1 2 3 4 5 > >> 1 Risk Assessment of Breast and...

189

First $?K$ atom lifetime and $?K$ scattering length measurements  

E-Print Network [OSTI]

The results of a search for hydrogen-like atoms consisting of $\\pi^{\\mp}K^{\\pm}$ mesons are presented. Evidence for $\\pi K$ atom production by 24 GeV/c protons from CERN PS interacting with a nickel target has been seen in terms of characteristic $\\pi K$ pairs from their breakup in the same target ($178 \\pm 49$) and from Coulomb final state interaction ($653 \\pm 42$). Using these results the analysis yields a first value for the $\\pi K$ atom lifetime of $\\tau=(2.5_{-1.8}^{+3.0})$ fs and a first model-independent measurement of the S-wave isospin-odd $\\pi K$ scattering length $\\left|a_0^-\\right|=\\frac{1}{3}\\left|a_{1/2}-a_{3/2}\\right|= \\left(0.11_{-0.04}^{+0.09} \\right)M_{\\pi}^{-1}$ ($a_I$ for isospin $I$).

B. Adeva; L. Afanasyev; Y. Allkofer; C. Amsler; A. Anania; S. Aogaki; A. Benelli; V. Brekhovskikh; T. Cechak; M. Chiba; P. Chliapnikov; C. Ciocarlan; S. Constantinescu; P. Doskarova; D. Drijard; A. Dudarev; M. Duma; D. Dumitriu; D. Fluerasu; A. Gorin; O. Gorchakov; K. Gritsay; C. Guaraldo; M. Gugiu; M. Hansroul; Z. Hons; S. Horikawa; Y. Iwashita; V. Karpukhin; J. Kluson; M. Kobayashi; V. Kruglov; L. Kruglova; A. Kulikov; E. Kulish; A. Kuptsov; A. Lamberto; A. Lanaro; R. Lednicky; C. Mariñas; J. Martincik; L. Nemenov; M. Nikitin; K. Okada; V. Olchevskii; M. Pentia; A. Penzo; M. Plo; T. Ponta; P. Prusa; G. Rappazzo; A. Romero Vidal; A. Ryazantsev; V. Rykalin; J. Schacher; A. Sidorov; J. Smolik; S. Sugimoto; F. Takeutchi; L. Tauscher; T. Trojek; S. Trusov; T. Urban; T. Vrba; V. Yazkov; Y. Yoshimura; M. Zhabitsky; P. Zrelov

2014-03-04T23:59:59.000Z

190

Measurements of ultracold neutron lifetimes in solid deuterium  

E-Print Network [OSTI]

We present the first measurements of the survival time of ultracold neutrons (UCNs) in solid deuterium SD2. This critical parameter provides a fundamental limitation to the effectiveness of superthermal UCN sources that utilize solid ortho-deuterium as the source material. Superthermal UCN sources offer orders of magnitude improvement in the available densities of UCNs, and are of great importance to fundamental particle-physics experiments such as searches for a static electric dipole moment and lifetime measurements of the free neutron. These measurements are performed utilizing a SD2 source coupled to a spallation source of neutrons, providing a demonstration of UCN production in this geometry and permitting systematic studies of the influence of thermal up-scatter and contamination with para-deuterium on the UCN survival time.

C. L. Morris; J. M. Anaya; T. J. Bowles; B. W. Filippone; P. Geltenbort; R. E. Hill; M. Hino; S. Hoedl; G. E. Hogan; T. M. Ito; T. Kawai; K. Kirch; S. K. Lamoreaux; C. -Y. Liu; M. Makela; L. J. Marek; J. W. Martin; R. N. Mortensen; A. Pichlmaier; A. Saunders; S. J. Seestrom; D. Smith; W. Teasdale; B. Tipton; M. Utsuro; A. R. Young; J. Yuan

2001-09-28T23:59:59.000Z

191

Measurement of the B hadron lifetime at the SLC  

SciTech Connect (OSTI)

We have measured the average B hadron lifetime from Z{sup 0} {r arrow} b{bar b} events using the Mark II detector at the SLC. We use an impact parameter tag, requiring two or more tracks with significant impact parameter ({delta}) in a hemisphere, to obtain a 40% efficiency and an 80% B-purity. The {Sigma}{delta} distribution from charged tracks in the hemisphere opposite the tag is used to fit for {tau}{sub b}. From 53 tagged B decays we find {tau}{sub b} = 1.63{sub {minus}0.40}{sup +0.64}(stat) {plus minus}0.16(syst) psec (preliminary), consistent with the world average. This method can be competitive with {tau}{sub b} measurements using high P{sub T} leptons and has a different sensitivity to {tau}(B{sup +})/{tau}(B{sup 0}).

Fujino, D.

1991-11-01T23:59:59.000Z

192

Measurement of the B hadron lifetime at the SLC  

SciTech Connect (OSTI)

We have measured the average B hadron lifetime from Z{sup 0} {r_arrow} b{bar b} events using the Mark II detector at the SLC. We use an impact parameter tag, requiring two or more tracks with significant impact parameter ({delta}) in a hemisphere, to obtain a 40% efficiency and an 80% B-purity. The {Sigma}{delta} distribution from charged tracks in the hemisphere opposite the tag is used to fit for {tau}{sub b}. From 53 tagged B decays we find {tau}{sub b} = 1.63{sub {minus}0.40}{sup +0.64}(stat) {plus_minus}0.16(syst) psec (preliminary), consistent with the world average. This method can be competitive with {tau}{sub b} measurements using high P{sub T} leptons and has a different sensitivity to {tau}(B{sup +})/{tau}(B{sup 0}).

Fujino, D.; The MARK II Collaboration.

1991-11-01T23:59:59.000Z

193

The lifetime problem of evaporating black holes: mutiny or resignation  

E-Print Network [OSTI]

It is logically possible that regularly evaporating black holes exist in nature. In fact, the prevalent theoretical view is that these are indeed the real objects behind the curtain in astrophysical scenarios. There are several proposals for regularizing the classical singularity of black holes so that their formation and evaporation do not lead to information-loss problems. One characteristic is shared by most of these proposals: these regularly evaporating black holes present long-lived trapping horizons, with absolutely enormous evaporation lifetimes in whatever measure. Guided by the discomfort with these enormous and thus inaccessible lifetimes, we elaborate here on an alternative regularization of the classical singularity, previously proposed by the authors in an emergent gravity framework, which leads to a completely different scenario. In our scheme the collapse of a stellar object would result in a genuine time-symmetric bounce, which in geometrical terms amounts to the connection of a black-hole geometry with a white-hole geometry in a regular manner. The two most differential characteristics of this proposal are: i) the complete bouncing geometry is a solution of standard classical general relativity everywhere except in a transient region that necessarily extends beyond the gravitational radius associated with the total mass of the collapsing object; and ii) the duration of the bounce as seen by external observers is very brief (fractions of milliseconds for neutron-star-like collapses). This scenario motivates the search for new forms of stellar equilibrium different from black holes. In a brief epilogue we compare our proposal with a similar geometrical setting recently proposed by Haggard and Rovelli.

Carlos Barceló; Raúl Carballo-Rubio; Luis J. Garay; Gil Jannes

2015-02-09T23:59:59.000Z

194

Local Measurement of Fuel Energy Deposition and Heat Transfer Environment During Fuel Lifetime Using Controlled Calorimetry  

SciTech Connect (OSTI)

A comprehensive description of the accomplishments of the DOE grant titled, ''Local Measurement of Fuel Energy Deposition and Heat Transfer Environment During Fuel Lifetime using Controlled Calorimetry''.

Don W. Miller; Andrew Kauffmann; Eric Kreidler; Dongxu Li; Hanying Liu; Daniel Mills; Thomas D. Radcliff; Joseph Talnagi

2001-12-31T23:59:59.000Z

195

E-Print Network 3.0 - annihilation lifetime measurement Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with recent positron lifetime measurements for group IV and V refractory metal carbides and in hexagonal WC... ; this is lower than the values found for most transition...

196

E-Print Network 3.0 - accurate atomic lifetime Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

compared... with recent positron lifetime measurements for group IV and V refractory metal carbides and in hexagonal WC... a very high electronic density. The corresponding...

197

E-Print Network 3.0 - analysing positron lifetime Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with recent positron lifetime measurements for group IV and V refractory metal carbides and in hexagonal WC... a very high electronic density. The corresponding positron ......

198

Market Based Risk Mitigation: Risk Management vs. Risk Avoidance  

E-Print Network [OSTI]

Market Based Risk Mitigation: Risk Management vs. Risk Avoidance Shmuel Oren University of the critical infrastructures in our society. Risk assessment and systematic consideration of risk in the design knowledge for engineers, like physics for instance, consideration of risk has penetrated all engineering

199

LIFETIME PREDICTION FOR MODEL 9975 O-RINGS IN KAMS  

SciTech Connect (OSTI)

The Savannah River Site (SRS) is currently storing plutonium materials in the K-Area Materials Storage (KAMS) facility. The materials are packaged per the DOE 3013 Standard and transported and stored in KAMS in Model 9975 shipping packages, which include double containment vessels sealed with dual O-rings made of Parker Seals compound V0835-75 (based on Viton{reg_sign} GLT). The outer O-ring of each containment vessel is credited for leaktight containment per ANSI N14.5. O-ring service life depends on many factors, including the failure criterion, environmental conditions, overall design, fabrication quality and assembly practices. A preliminary life prediction model has been developed for the V0835-75 O-rings in KAMS. The conservative model is based primarily on long-term compression stress relaxation (CSR) experiments and Arrhenius accelerated-aging methodology. For model development purposes, seal lifetime is defined as a 90% loss of measurable sealing force. Thus far, CSR experiments have only reached this target level of degradation at temperatures {ge} 300 F. At lower temperatures, relaxation values are more tolerable. Using time-temperature superposition principles, the conservative model predicts a service life of approximately 20-25 years at a constant seal temperature of 175 F. This represents a maximum payload package at a constant ambient temperature of 104 F, the highest recorded in KAMS to date. This is considered a highly conservative value as such ambient temperatures are only reached on occasion and for short durations. The presence of fiberboard in the package minimizes the impact of such temperature swings, with many hours to several days required for seal temperatures to respond proportionately. At 85 F ambient, a more realistic but still conservative value, bounding seal temperatures are reduced to {approx}158 F, with an estimated seal lifetime of {approx}35-45 years. The actual service life for O-rings in a maximum wattage package likely lies higher than the estimates due to the conservative assumptions used for the model. For lower heat loads at similar ambient temperatures, seal lifetime is further increased. The preliminary model is based on several assumptions that require validation with additional experiments and longer exposures at more realistic conditions. The assumption of constant exposure at peak temperature is believed to be conservative. Cumulative damage at more realistic conditions will likely be less severe but is more difficult to assess based on available data. Arrhenius aging behavior is expected, but non-Arrhenius behavior is possible. Validation of Arrhenius behavior is ideally determined from longer tests at temperatures closer to actual service conditions. CSR experiments will therefore continue at lower temperatures to validate the model. Ultrasensitive oxygen consumption analysis has been shown to be useful in identifying non-Arrhenius behavior within reasonable test periods. Therefore, additional experiments are recommended and planned to validate the model.

Hoffman, E.; Skidmore, E.

2009-11-24T23:59:59.000Z

200

SO2 emissions and lifetimes: Estimates from inverse modeling using in situ and global, spacebased  

E-Print Network [OSTI]

SO2 emissions and lifetimes: Estimates from inverse modeling using in situ and global, spacebased 18 March 2011. [1] Topdown constraints on global sulfur dioxide (SO2) emissions are inferred through of GEOSChem for inversion of SO2 columns to emissions. The seasonal mean SO2 lifetime calculated with the GEOS

Martin, Randall

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

On Lifetime Extension and Route Stabilization of Energy-Efficient Broadcast Routing over MANET  

E-Print Network [OSTI]

of network lifetime. Keywords MANET, Adhoc Networks, Energy Efficient Routing, Multicasting Tree, BIP an approach that tries to develop energy-efficient broadcast routing trees. They presented a tree constructionOn Lifetime Extension and Route Stabilization of Energy- Efficient Broadcast Routing over MANET

Poovendran, Radha

202

Maximizing Lifetime in an Energy Constrained Wireless Sensor Array Using Team Optimization  

E-Print Network [OSTI]

Maximizing Lifetime in an Energy Constrained Wireless Sensor Array Using Team Optimization of Cooperating Systems Robert J. Marks II, Arindam K. Das, Mohamed El-Sharkawi Department of Electrical trees to do this. For a known node constellation, the maximum lifetime of a single tree is equal

Arabshahi, Payman

203

Ris-R-1515(EN) Lifetime Modelling of Lead Acid Batteries  

E-Print Network [OSTI]

Profile 18 3.2 Wind and PV test profiles for lifetime assessment 19 3.2.1 Renewable energy system profiles-01 Sponsorship: Cover : Pages: 82 Tables: 10 References: 18 Abstract: The performance and lifetime of energy storage in batteries are an important part of many renewable based energy systems. Not only do batteries

204

Environment and the Lifetime of Tropical Deep Convection in a Cloud-Permitting Regional Model Simulation  

SciTech Connect (OSTI)

By applying a cloud tracking algorithm to tropical convective systems simulated by a regional high resolution model, the study documents environmental conditions before and after convective systems are initiated over ocean and land by following them during their lifetime. The comparative roles of various environmental fields in affecting the lifetime of convection are also quantified. The statistics of lifetime, maximum area, propagation speed and direction of the simulated deep convection agrees well with geostationary satellite observations. Over ocean, convective systems enhance surface fluxes through the associated wind gusts as well as cooling and drying of the boundary layer. A significant relationship is found between the mean surface fluxes during their lifetime and the longevity of the systems which in turn is related to the initial intensity of the moist updraft and to a lesser extent upper level shear. Over land, on the other hand, convective activity suppresses surface fluxes through cloud cover and the lifetime of convection is related to the upper level shear during their lifetime and strength of the heat fluxes several hours before the initiation of convection. For systems of equal lifetime, those over land are significantly more intense than those over ocean especially during early stages of their lifetime.

Hagos, Samson M.; Feng, Zhe; McFarlane, Sally A.; Leung, Lai-Yung R.

2013-08-01T23:59:59.000Z

205

Post-Doctoral Research Associate Position in Photovoltaic Lifetime and Degradation Science  

E-Print Network [OSTI]

Post-Doctoral Research Associate Position in Photovoltaic Lifetime and Degradation Science A Post establish a facility for PV lifetime and degradation studies, including solar and environmental exposures and optical characterization techniques including UV/vis, FTIR and light scattering, and will develop

Rollins, Andrew M.

206

NEUTRON DAMAGE IN REACTOR PRESSURE-VESSEL STEEL EXAMINED WITH POSITRON ANNIHILATION LIFETIME SPECTROSCOPY  

E-Print Network [OSTI]

NEUTRON DAMAGE IN REACTOR PRESSURE-VESSEL STEEL EXAMINED WITH POSITRON ANNIHILATION LIFETIME-vessel steels. We irradiated samples ofASTM A508 nuclear reactor pressure-vessel steel to fast neutron 17 2 (PALS) to study the effects of neutron damage in the steels on positron lifetimes. Non

Motta, Arthur T.

207

Investigating Upper Bounds on Network Lifetime Extension for Cell-Based Energy Conservation Techniques  

E-Print Network [OSTI]

Investigating Upper Bounds on Network Lifetime Extension for Cell-Based Energy Conservation either for a base network (one without any energy conservation technique) or for one using cooperative energy conservation strategies. In this paper, we investigate the lifetime/density tradeoff under

Santi, Paolo

208

On how to calculate methane lifetime from OH concentrations (FORTRAN): Integer I, J, L ! counters  

E-Print Network [OSTI]

On how to calculate methane lifetime from OH concentrations (FORTRAN): Integer I, J, L ! counters_ch4 ! methane lifetime (years) C Initialize: ch4_sum=0. yield=0. C Calculate sums: Do J = 1 , JM Do I in tropospheric ozone and methane; global 3D model studies, Atmospheric Environment, 33, 961-977, 1999

Haak, Hein

209

A LIFETIME PREDICTION MODEL FOR SINGLE CRYSTAL SUPERALLOYS SUBJECTED TO THERMOMECHANICAL  

E-Print Network [OSTI]

-FATIGUE-OXIDATION DAMAGE A. M. ALAM1 and L. REMY2 1 ALSTOM (Power), Gas Turbine Design Department, Brown Boveri Strasse 7A LIFETIME PREDICTION MODEL FOR SINGLE CRYSTAL SUPERALLOYS SUBJECTED TO THERMOMECHANICAL CREEP 91003, Evry, France ABSTRACT This paper contains a brief description of a lifetime prediction model

Paris-Sud XI, Université de

210

Novel Battery Thermal Management System for Greater Lifetime Ratifying Current Quality and Safety Standard  

E-Print Network [OSTI]

acceptance; o power and energy capability; o reliability; o lifetime and life cycle cost. ThereofNovel Battery Thermal Management System for Greater Lifetime Ratifying Current Quality and Safety,Denmark. Temperature excursions and non-uniformity of the temperature inside the battery systems are the main concern

Andreasen, Søren Juhl

211

CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM  

E-Print Network [OSTI]

CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM 2010 ANNUAL REPORT WITH STATISTICAL DATA FROM 2009 UNIVERSITY OF ILLINOIS MEDICAL CENTER #12;2 CANCER PROGRAM ANNUAL REPORT 2 #12;3 CANCER PROGRAM ANNUAL REPORT 3 UIMC CANCER PROGRAM CHANGING MULTIDISCIPLINARY CARE. FOR GOOD. #12;4 CANCER PROGRAM ANNUAL REPORT

Illinois at Chicago, University of

212

Measuring the Neutron Lifetime Using Magnetically Trapped Neutrons  

E-Print Network [OSTI]

The neutron beta-decay lifetime plays an important role both in understanding weak interactions within the framework of the Standard Model and in theoretical predictions of the primordial abundance of 4He in Big Bang Nucleosynthesis. In previous work, we successfully demonstrated the trapping of ultracold neutrons (UCN) in a conservative potential magnetic trap. A major upgrade of the apparatus is nearing completion at the National Institute of Standards and Technology Center for Neutron Research (NCNR). In our approach, a beam of 0.89 nm neutrons is incident on a superfluid 4He target within the minimum field region of an Ioffe-type magnetic trap. A fraction of the neutrons is downscattered in the helium to energies <200 neV, and those in the appropriate spin state become trapped. The inverse process is suppressed by the low phonon density of helium at temperatures less than 200 mK, allowing the neutron to travel undisturbed. When the neutron decays the energetic electron ionizes the helium, producing scintillation light that is detected using photomultiplier tubes. Statistical limitations of the previous apparatus will be alleviated by significant increases in field strength and trap volume resulting in twenty times more trapped neutrons.

C. M. O'Shaughnessy; R. Golub; K. W. Schelhammer; C. M. Swank; P. -N. Seo; P. R. Huffman; S. N. Dzhosyuk; C. E. H. Mattoni; L. Yang; J. M. Doyle; K. J. Coakley; A. K. Thompson; H. P. Mumm; S. K. Lamoreaux; G. Yang

2009-03-31T23:59:59.000Z

213

Measuring the Neutron Lifetime Using Magnetically Trapped Neutrons  

E-Print Network [OSTI]

The neutron beta-decay lifetime plays an important role both in understanding weak interactions within the framework of the Standard Model and in theoretical predictions of the primordial abundance of 4He in Big Bang Nucleosynthesis. In previous work, we successfully demonstrated the trapping of ultracold neutrons (UCN) in a conservative potential magnetic trap. A major upgrade of the apparatus is nearing completion at the National Institute of Standards and Technology Center for Neutron Research (NCNR). In our approach, a beam of 0.89 nm neutrons is incident on a superfluid 4He target within the minimum field region of an Ioffe-type magnetic trap. A fraction of the neutrons is downscattered in the helium to energies <200 neV, and those in the appropriate spin state become trapped. The inverse process is suppressed by the low phonon density of helium at temperatures less than 200 mK, allowing the neutron to travel undisturbed. When the neutron decays the energetic electron ionizes the helium, producing sci...

O'Shaughnessy, C M; Schelhammer, K W; Swank, C M; Seo, P -N; Huffman, P R; Dzhosyuk, S N; Mattoni, C E H; Yang, L; Doyle, J M; Coakley, K J; Thompson, A K; Mumm, H P; Lamoreaux, S K; Yang, G

2009-01-01T23:59:59.000Z

214

Battery Lifetime Analysis and Simulation Tool (BLAST) Documentation  

SciTech Connect (OSTI)

The deployment and use of lithium-ion batteries in automotive and stationary energy storage applications must be optimized to justify their high up-front costs. Given that batteries degrade with use and storage, such optimizations must evaluate many years of operation. As the degradation mechanisms are sensitive to temperature, state-of-charge histories, current levels, and cycle depth and frequency, it is important to model both the battery and the application to a high level of detail to ensure battery response is accurately predicted. To address these issues, the National Renewable Energy Laboratory has developed the Battery Lifetime Analysis and Simulation Tool (BLAST) suite of tools. This suite of tools pairs NREL's high-fidelity battery degradation model with a battery electrical and thermal performance model, application-specific electrical and thermal performance models of the larger system (e.g., an electric vehicle), application-specific system use data (e.g., vehicle travel patterns and driving data), and historic climate data from cities across the United States. This provides highly realistic, long-term predictions of battery response and thereby enables quantitative comparisons of varied battery use strategies.

Neubauer, J.

2014-12-01T23:59:59.000Z

215

Cancer Imaging Clinical Cancer Research  

E-Print Network [OSTI]

Purpose: Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging of tumors. In this study, we show the preferential uptake and retention of two hepatamethine cyanine dyes, IR-783 and MHI-148, in tumor cells and tissues. Experimental Design: IR-783 and MHI-148 were investigated for their ability to accumulate in human cancer cells, tumor xenografts, and spontaneous mouse tumors in transgenic animals. Time- and concentration-dependent dye uptake and retention in normal and cancer cells and tissues were compared, and subcellular localization of the dyes and mechanisms of the dye uptake and retention in tumor cells were evaluated using organelle-specific tracking dyes and bromosulfophthalein, a competitive inhibitor of organic anion transporting peptides. These dyes were used to detect human cancer metastases in a mouse model and differentiate cancer cells from normal cells in blood. Results: These near-IR hepatamethine cyanine dyes were retained in cancer cells but not normal cells, in tumor xenografts, and in spontaneous tumors in transgenic mice. They can be used to detect cancer metastasis and cancer cells in blood with a high degree of sensitivity. The dyes were found to concentrate in the mitochondria and lysosomes of cancer cells, probably through organic anion transporting peptides,

Near Ir; Heptamethine Cyanine Dye–mediated; Xiaojian Yang; Chunmeng Shi; Rong Tong; Weiping Qian; Haiyen E. Zhau; Ruoxiang Wang; Guodong Zhu; Jianjun Cheng; Vincent W. Yang; Tianmin Cheng; Maged Henary; Lucjan Strekowski; W. K. Chung

216

First working group meeting on the minority carrier diffusion length/lifetime measurement: Results of the round robin lifetime/diffusion length tests  

SciTech Connect (OSTI)

As was noted in the cover letter that accompanied the samples, the eleven bare silicon samples were from various manufacturers. Table I lists the codes for the samples and the manufacturer of each sample. It also notes if the sample was single or poly-crystalline. The samples had been polished on one side before being sent out for measurements, but no further processing was done. The participants of the study were asked to measure either the lifetime or diffusion length of each of the samples using their standard procedure. Table II shows the experimental conditions used by the groups who measured diffusion length. All the diffusion length measurements were performed using the Surface Photovoltage method (SPV). Table M shows the experimental conditions for the lifetime measurements. All the lifetime measurements were made using the Photoconductance Decay method (PCD) under low level injection. These tables show the diameter of the spot size used during the measurement (the effective sampling area), the locations where measurements were taken, and the number of measurements taken at each location. Table N shows the results of the measurements. The table is divided into diffusion length and lifetime measurements for each sample. The values listed are the average values reported by each group. One of the immediate artifacts seen in the data is the large variation in the lifetime measurements. The values from MIT and Mobil are generally close. However, the measurements from NCSU are typically an order of magnitude lower.

Cudzinovic, M.; Sopori, B. [comp.] [comp.

1995-11-01T23:59:59.000Z

217

Los Alamos National Laboratory W76 Pit Tube Lifetime Study  

SciTech Connect (OSTI)

A metallurgical study was requested as part of the Los Alamos National Laboratory (LANL) W76-1 life-extension program (LEP) involving a lifetime analysis of type 304 stainless steel pit tubes subject to repeat bending loads during assembly and disassembly operations at BWXT/Pantex. This initial test phase was completed during the calendar years of 2004-2006 and the report not issued until additional recommended tests could be performed. These tests have not been funded to this date and therefore this report is considered final. Tubes were reportedly fabricated according to Rocky Flats specification P14548 - Seamless Type 304 VIM/VAR Stainless Steel Tubing. Tube diameter was specified as 0.125 inches and wall thickness as 0.028 inches. A heat treat condition is not specified and the hardness range specification can be characteristic of both 1/8 and 1/4 hard conditions. Properties of all tubes tested were within specification. Metallographic analysis could not conclusively determine a specified limit to number of bends allowable. A statistical analysis suggests a range of 5-7 bends with a 99.95% confidence limit. See the 'Statistical Analysis' section of this report. The initial phase of this study involved two separate sets of test specimens. The first group was part of an investigation originating in the ESA-GTS [now Gas Transfer Systems (W-7) Group]. After the bend cycle test parameters were chosen (all three required bends subjected to the same amount of bend cycles) and the tubes bent, the investigation was transferred to Terri Abeln (Metallurgical Science and Engineering) for analysis. Subsequently, another limited quantity of tubes became available for testing and were cycled with the same bending fixture, but with different test parameters determined by T. Abeln.

Abeln, Terri G. [Los Alamos National Laboratory

2012-04-25T23:59:59.000Z

218

“It’s Not If I Get Cancer, It’s When I Get Cancer”: Exploring Previvors’ Management of Uncertainty for Hereditary Cancer in Clinical Encounters  

E-Print Network [OSTI]

decisions affect their subsequent sense of uncertainty. A previvor is an individual who is highly predisposed to breast and ovarian cancer due to a genetic mutation called BRCA1/2. Previvors have a 44 to 87 percent risk of developing cancer during...

Dean, Marleah Lynn

2014-07-10T23:59:59.000Z

219

Bulk Tungsten in the JET Divertor: Potential Influence of the Exhaustion of Ductility and Grain Growth on the Lifetime  

E-Print Network [OSTI]

Bulk Tungsten in the JET Divertor: Potential Influence of the Exhaustion of Ductility and Grain Growth on the Lifetime

220

Laser spectroscopic studies of state-dependent collisional quenching of the lifetimes of metastable antiprotonic helium atoms  

E-Print Network [OSTI]

Laser spectroscopic studies of state-dependent collisional quenching of the lifetimes of metastable antiprotonic helium atoms

Hori, M; Torii, H A; Ishikawa, T; Maas, F E; Yamazaki, T; Eades, John; Widmann, E; Kumakara, M; Morita, N; Sugai, I; Horváth, D; Ketzer, B; Hartmann, F J; Maierl, C; Hasinoff, M D; Von Egidy, T; Tamura, H

1998-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Does living near heavy industry cause lung cancer in women? A case control study using life grid interviews.   

E-Print Network [OSTI]

of a modestly raised risk of lung cancer with prolonged residence close to heavy industry, although the confidence intervals were wide. The effect of air pollution on the incidence of lung cancer merits continued study....

Edwards, R; Pless-Mulloli, T; Howel, D; Chadwick, TJ; Bhopal, Raj; Harrison, R N; Gribbin, H

2006-10-13T23:59:59.000Z

222

Advanced Models and Controls for Prediction and Extension of Battery Lifetime (Presentation)  

SciTech Connect (OSTI)

Predictive models of capacity and power fade must consider a multiplicity of degradation modes experienced by Li-ion batteries in the automotive environment. Lacking accurate models and tests, lifetime uncertainty must presently be absorbed by overdesign and excess warranty costs. To reduce these costs and extend life, degradation models are under development that predict lifetime more accurately and with less test data. The lifetime models provide engineering feedback for cell, pack and system designs and are being incorporated into real-time control strategies.

Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G.; Pesaran, A.

2014-02-01T23:59:59.000Z

223

Exciton Lifetime Paradoxically Enhanced by Dissipation and Decoherence - Toward Efficient Energy Conversion of Solar Cell  

E-Print Network [OSTI]

Energy dissipation and decoherence are at first glance harmful to acquiring long exciton lifetime desired for efficient photovoltaics. In the presence of both optically forbidden (namely, dark) and allowed (bright) excitons, however, they can be instrumental as suggested in photosynthesis. By simulating quantum dynamics of exciton relaxations, we show that the optimized decoherence that imposes a quantum-to-classical crossover with the dissipation realizes a dramatically longer lifetime. In an example of carbon nanotube, the exciton lifetime increases by nearly two orders of magnitude when the crossover triggers stable high population in the dark exciton.

Yamada, Yasuhiro; Imada, Masatoshi

2015-01-01T23:59:59.000Z

224

Exciton Lifetime Paradoxically Enhanced by Dissipation and Decoherence - Toward Efficient Energy Conversion of Solar Cell  

E-Print Network [OSTI]

Energy dissipation and decoherence are at first glance harmful to acquiring long exciton lifetime desired for efficient photovoltaics. In the presence of both optically forbidden (namely, dark) and allowed (bright) excitons, however, they can be instrumental as suggested in photosynthesis. By simulating quantum dynamics of exciton relaxations, we show that the optimized decoherence that imposes a quantum-to-classical crossover with the dissipation realizes a dramatically longer lifetime. In an example of carbon nanotube, the exciton lifetime increases by nearly two orders of magnitude when the crossover triggers stable high population in the dark exciton.

Yasuhiro Yamada; Youhei Yamaji; Masatoshi Imada

2015-02-25T23:59:59.000Z

225

Generation and Recombination Carrier Lifetimes in 4H SiC Epitaxial Wafers , M. J. Loboda1)  

E-Print Network [OSTI]

Generation and Recombination Carrier Lifetimes in 4H SiC Epitaxial Wafers G. Chung1) , M. J. Loboda comparative studies of recombination and carrier lifetimes in SiC. For the first time, both generation-wafer structures. The ratio of the generation to recombination lifetime is much different in SiC compared to Si

Schroder, Dieter K.

226

Risk Without Return  

E-Print Network [OSTI]

and Mitra, I. (2010). Extreme risk analysis. The Journal offrom the fact that the risk parity strategy was diversifiedboth in capital and in risk weights. Further research into

Goldberg, Lisa R.; Mahmoud, Ola

2013-01-01T23:59:59.000Z

227

Norwegian National Program for Lifetime Commissioning and Energy Efficient Operation of Buildings  

E-Print Network [OSTI]

The project “Life-Time Commissioning for Energy Efficient Operation of Buildings” is actually a network of industrial companies, private and public entities, and R&D organizations. The overall objective of the project is to contribute...

Novakovic, V.; Djuric, N.; Holst, J.; Frydenlund, F.

2006-01-01T23:59:59.000Z

228

Comparison of spatially resolved carrier lifetimes in mc-Si with solar cell and material characteristics  

SciTech Connect (OSTI)

The authors introduce a novel application of modulated free carrier absorption (MFCA) for measuring minority carrier lifetimes in multicrystalline silicon with high spatial resolution. The improved lateral resolution compared to other contactless techniques allows the correlation between these lifetime maps and solar cell characteristics as well as microscopic properties, like dislocations, precipitates, oxygen concentration, etc. Comparisons of the lifetime maps measured on the starting material and light beam induced current (LBIC) maps exhibit a very good qualitative correlation of the structures observed in both cases. In addition, correlations to microscopic characteristics like high dislocation density in regions with low lifetimes are investigated and a comparison with spatially resolved FT-IR measurements of the interstitial oxygen concentration is performed.

Glunz, S.W.; Hebling, C.; Warta, W.; Wettling, W. [Fraunhofer-Inst. fuer Solare Energiesysteme, Freiburg (Germany)

1994-12-31T23:59:59.000Z

229

Measurement and model assessment of fluorescence lifetime sensing in multiply scattering media  

E-Print Network [OSTI]

fluorescent dyes, 3,3-diethylthiatricarbocyanine iodide (DTTCI) and Indocynanine Green (ICG), which exhibit distinctly different lifetimes and each exhibits single-exponential decay kinetics, were employed. Measurements of phase-modulation as a function...

Kuwana, Eddy

2005-08-29T23:59:59.000Z

230

Sacrificial high-temperature phosphorus diffusion gettering for lifetime improvement of multicrystalline silicon wafers  

E-Print Network [OSTI]

Iron is among the most deleterious lifetime-limiting impurities in crystalline silicon solar cells. In as-grown material, iron is present in precipitates and in point defects. To achieve conversion efficiencies in excess ...

Scott, Stephanie Morgan

2014-01-01T23:59:59.000Z

231

E-Print Network 3.0 - atomic lifetime based Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with halogen atom. Nonetheless, we are able to account for the magnitudes of the caX and SrX lifetimes to 4... ). 19The computer programs used are based on those written by...

232

Quasiparticle lifetimes in magnesium clusters modeled by self-consistent GW? calculations  

E-Print Network [OSTI]

Quasiparticle (QP) lifetimes in magnesium clusters are calculated using many-body Green's-function theory. We analyze the effect of the self-consistency of the one-particle Green's function G on the calculations and ...

He, Yi

233

Lifetime measurements of high-lying short lived states in {sup 69}As  

SciTech Connect (OSTI)

Lifetimes of high-spin states in {sup 69}As have been measured using Doppler shift attenuation technique with the GASP and RFD setup. The determined transition probabilities indicate large deformation associated with some rotational bands in this nucleus.

Matejska-Minda, M.; Bednarczyk, P.; Fornal, B.; Ciemala, M.; Kmiecik, M.; Krzysiek, M.; Maj, A.; Meczynski, W.; Myalski, S.; Styczen, J.; Zieblinski, M.; Angelis, G. de; Huyuk, T.; Michelagnoli, C.; Sahin, E.; Aydin, S.; Farnea, E.; Menegazzo, R.; Recchia, F.; Ur, C. A. [Institute of Nuclear Physics, Polish Academy of Sciences, Krakow (Poland); INFN, Laboratori Nazionali di Legnaro, Legnaro (Italy); Dipartimento di Fisica e INFN Padova (Italy); Dipartimento di Fisica e INFN Milano (Italy); Heavy Ion Laboratory, University of Warsaw (Poland); University of York (United Kingdom); and others

2012-10-20T23:59:59.000Z

234

Theory of SEI Formation in Rechargeable Batteries: Capacity Fade, Accelerated Aging and Lifetime Prediction  

E-Print Network [OSTI]

Cycle life is critically important in applications of rechargeable batteries, but lifetime prediction is mostly based on empirical trends, rather than mathematical models. In practical lithium-ion batteries, capacity fade ...

Pinson, Matthew Bede

235

The Application of Fluorescence Lifetime Imaging Microscopy to Quantitatively Map Mixing and Temperature in Microfluidic Systems   

E-Print Network [OSTI]

The technique of Fluorescence Lifetime Imaging Microscopy (FLIM) has been employed to quantitatively and spatially map the fluid composition and temperature within microfluidic systems. A molecular probe with a ...

Graham, Emmelyn M

2008-01-01T23:59:59.000Z

236

E-Print Network 3.0 - absorber element lifetime Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

) o - is the change in the ring-down lifetime without and with the absorber present... -water interface as a function of bulk pH by the direct measurement of the absorbance of...

237

AYUSH: A Technique for Extending Lifetime of SRAM-NVM Hybrid Caches  

SciTech Connect (OSTI)

Recently, researchers have explored way-based hybrid SRAM-NVM (non-volatile memory) last level caches (LLCs) to bring the best of SRAM and NVM together. However, the limited write endurance of NVMs restricts the lifetime of these hybrid caches. We present AYUSH, a technique to enhance the lifetime of hybrid caches, which works by using data-migration to preferentially use SRAM for storing frequently-reused data. Microarchitectural simulations confirm that AYUSH achieves larger improvement in lifetime than a previous technique and also maintains performance and energy efficiency. For single, dual and quad-core workloads, the average increase in cache lifetime with AYUSH is 6.90X, 24.06X and 47.62X, respectively.

Mittal, Sparsh [ORNL; Vetter, Jeffrey S [ORNL

2014-01-01T23:59:59.000Z

238

Improved Measurement of the Muon Lifetime and Determination of the Fermi Constant  

E-Print Network [OSTI]

The MuLan collaboration has measured the lifetime of the positve muon to a precision of 1.0 parts per million. The Fermi constant is determined to a precision of 0.6 parts per million.

P. T. Debevec

2011-08-22T23:59:59.000Z

239

Cascade Problems in Some Atomic Lifetime Measurements at a Heavy-Ion Storage Ring  

SciTech Connect (OSTI)

Lifetimes of 3s{sup 2}3p{sup k} ground configuration levels of Al-, Si-, P-, and S-like ions of Be, Co, and Ni have been measured at a heavy-ion storage ring. Some of the observed decay curves show strong evidence of cascade repopulation from specific 3d levels that feature lifetimes in the same multi-millisecond range as the levels of the ground configuration.

Trabert, E; Hoffmann, J; Krantz, C; Wolf, A; Ishikawa, Y; Santana, J

2008-10-09T23:59:59.000Z

240

A portable time-domain LED fluorimeter for nanosecond fluorescence lifetime measurements  

SciTech Connect (OSTI)

Fluorescence lifetime measurements are becoming increasingly important in chemical and biological research. Time-domain lifetime measurements offer fluorescence multiplexing and improved handling of interferers compared with the frequency-domain technique. In this paper, an all solid-state, filterless, and highly portable light-emitting-diode based time-domain fluorimeter (LED TDF) is reported for the measurement of nanosecond fluorescence lifetimes. LED based excitation provides more wavelengths options compared to laser diode based excitation, but the excitation is less effective due to the uncollimated beam, less optical power, and longer latency in state transition. Pulse triggering and pre-bias techniques were implemented in our LED TDF to improve the peak optical power to over 100 mW. The proposed pulsing circuit achieved an excitation light fall time of less than 2 ns. Electrical resetting technique realized a time-gated photo-detector to remove the interference of the excitation light with fluorescence. These techniques allow the LED fluorimeter to accurately measure the fluorescence lifetime of fluorescein down to concentration of 0.5 ?M. In addition, all filters required in traditional instruments are eliminated for the non-attenuated excitation/emission light power. These achievements make the reported device attractive to biochemical laboratories seeking for highly portable lifetime detection devices for developing sensors based on fluorescence lifetime changes. The device was initially validated by measuring the lifetimes of three commercial fluorophores and comparing them with reported lifetime data. It was subsequently used to characterize a ZnSe quantum dot based DNA sensor.

Wang, Hongtao; Salthouse, Christopher D., E-mail: salthouse@ecs.umass.edu [Electrical and Computer Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003 (United States); Center for Personalized Health Monitoring, University of Massachusetts, Amherst, Massachusetts 01003 (United States); Qi, Ying; Mountziaris, T. J. [Center for Personalized Health Monitoring, University of Massachusetts, Amherst, Massachusetts 01003 (United States) [Center for Personalized Health Monitoring, University of Massachusetts, Amherst, Massachusetts 01003 (United States); Chemical Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003 (United States)

2014-05-15T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Ratio of D/sup 0/ and D/sup +/ lifetimes from their semileptonic decays  

SciTech Connect (OSTI)

The conventional expectation for the decays of D mesons assumes that the charm quark decays in the presence of light, spectator quarks and thus the lifetimes of both charged and uncharged states are equal. In this article, evidence is presented from DELCO (at SPEAR) that the D lifetimes are quite different for neutral and charged mesons, and the results which have also become available from other experiments are reviewed.

Donaldson, G.J.

1980-06-01T23:59:59.000Z

242

D.E. Corpet / Meat Science 2011 -doi:10.1016/j.meatsci.2011.04.009 Red meat and colon cancer  

E-Print Network [OSTI]

D.E. Corpet / Meat Science 2011 - doi:10.1016/j.meatsci.2011.04.009 . 1 Red meat and colon cancer consumption on cancer risk is a controversial issue. However, recent meta-analyses show that high consumers of cured meats and red meat are at increased risk of colorectal cancer. This increase is significant

Paris-Sud XI, Université de

243

Examination of sun awareness behavior, knowledge, and attitudes before and after a sun awareness program in 4th to 8th grade students.  

E-Print Network [OSTI]

??Sun exposure is a potential risk factor for skin cancer and melanoma. Since most sun exposure during one's lifetime occurs during childhood, sun protection at… (more)

Tavares, Venessa

2007-01-01T23:59:59.000Z

244

Hurricane wind fields needed to assess risk to offshore wind farms  

E-Print Network [OSTI]

LETTER Hurricane wind fields needed to assess risk to offshore wind farms In their paper in PNAS losses attributable to hurricane activity at four hypothetical offshore wind farm sites. We found one a 20-y typical wind farm lifetime. They combined a county annual landfall frequency probability density

Jaramillo, Paulina

245

Enterprise Risk Management Program  

E-Print Network [OSTI]

..........................................................................23 Appendix C - ERM Program Goals, ERM Guiding Principles, and Institutional Risk Philosophy Enterprise Risk Management Program Guide to Risk Assessment & Response August 16, 2012 #12; i ........................................................................................................................3 Step 2: Risk Identification

Hayden, Nancy J.

246

Northern Kentucky University Honor Roll of Donors: Lifetime Giving Northern Kentucky University's lifetime giving societies recognize donors who have made significant contributions  

E-Print Network [OSTI]

Northern Kentucky University Honor Roll of Donors: Lifetime Giving Northern Kentucky University master's degrees are included. 1968 Society - ($5,000,000+) The Bank of Kentucky The Carol and Ralph Northern Kentucky Society - ($500,000+) William P. and Mary S. Butler Castellini Foundation Corporex Family

Boyce, Richard L.

247

LONG-CHAIN POLYUNSATURATED FATTY ACID INTAKE AND ITS RELATIONSHIP TO RED BLOOD CELL AND SERUM LONG-CHAIN POLYUNSATURATED FATTY ACIDS IN WOMEN AT HIGH RISK FOR BREAST CANCER  

E-Print Network [OSTI]

questionnaire (DHQ). The mean age of the subjects was 47 ± 9.9 years, and the mean body mass index (BMI) was 25 ± 4.4. The mean 5-year Gail risk was 2.7 ± 2.2%. Twenty-two (48%) of the subjects were premenopausal and 24 (52%) were postmenopausal. Fifteen (33...

Harvey, Katherine

2010-04-27T23:59:59.000Z

248

Radiation risk to low fluences of particles may be greater than we thought  

E-Print Network [OSTI]

Radiation risk to low fluences of particles may be greater than we thought Hongning Zhou*, Masao on Radiation Protection and Measurements (NCRP) have recommended that estimates of cancer risk for low dose to reconsider the validity of the linear extrapolation in making risk estimates for low dose, high linear

249

Reflections in Mutation Research Electric light causes cancer?  

E-Print Network [OSTI]

]. And on a population level, there is a strong international correlation between estimates of per capita fat consumption dismayed by the recent reports that dietary fat consumption was unrelated to risk of breast cancer in women prospective cohort studies, estimates of fat consumption for individual women and risk to those women

Oliver, Douglas L.

250

Josephine Ford Cancer Center Cancer Research Programs  

E-Print Network [OSTI]

Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

Berdichevsky, Victor

251

Simulation free measurement of the B+ lifetime using decays selected using displaced tracks  

SciTech Connect (OSTI)

The lifetime of the B{sup {+-}} meson is measured using the decay channel B{sup +} {yields} {bar D}{sup 0}{pi}{sup +}. The measurement is made using approximately 1.0 fb{sup -1} of Tevatron proton-anti-proton collision data at {radical}s = 1.96 TeV collected by the CDF detector. The data were collected using impact parameter based triggers that were designed to select events with a secondary vertex. The trigger selection criteria result in data rich in a variety of B hadron decays, but intrinsically bias the lifetime distribution of the collected signal events. The traditional way to compensate for the bias is to use information from simulation. Presented here is a new method for correction of the lifetime bias using an analytical technique that uses information from the data only. This eliminates measurement uncertainty due to data and simulation agreement, ultimately resulting in a smaller systematic measurement uncertainty. The B{sup {+-}} lifetime measurement is the first measurement using this new technique and demonstrates its potential for use in future measurements. The B{sup {+-}} lifetime is measured to be {tau}(B{sup {+-}}) = 1.662 {+-} 0.023(stat) {+-} 0.015(syst)ps.

Malde, Sneha; /Oxford U.

2009-03-01T23:59:59.000Z

252

What is the probability that radiation caused a particular cancer  

SciTech Connect (OSTI)

Courts, lawyers, health physicists, physicians, and others are searching for a credible answer to the question posed in the title of this paper. The cases in which the question arises frequently stem from an individual that has cancer and they, or their next-of-kin, are convinced that a past radiation exposure - usually small - is responsible for causing it. An arithmetic expression of this problem is simple: the probability of causation by the radiation dose in question is equal to the risk of cancer from the radiation dose divided by the risk of cancer from all causes. The application of risk factors to this equation is not so simple. It must involve careful evaluation of the reliability of and variations in risk coefficients for development of cancer due to radiation exposure, other carcinogenic agents, and natural causes for the particular individual. Examination of our knowledge of these various factors indicates that a large range in the answers can result due to the variability and imprecision of the data. Nevertheless, the attempts to calculate and the probability that radiation caused the cancer is extremely useful to provide a gross perspective on the probability of causation. It will likely rule in or out a significant number of cases despite the limitations in our understandings of the etiology of cancer and the risks from various factors. For the remaining cases, a thoughtful and educated judgment based on selected data and circumstances of the case will also be needed before the expert can develop and support his opinion.

Voelz, G.L.

1983-01-01T23:59:59.000Z

253

Phonon lifetime in SiSn and its suitability for hot-carrier solar cells  

SciTech Connect (OSTI)

We present a phononic and electronic study of SiSn in the zinc-blende phase. A detailed description of the longitudinal optical (LO) phonon decay in a three-phonon process is presented together with the corresponding lifetime. The necessity to go beyond the zone center phonon approximation in this case is highlighted as it reveals a steep dependence of the lifetime on the initial phonon wavenumber, which differs from usual semiconductors. The electronic band structure is calculated within the GW formalism and shows a small direct band gap. It is shown that the LO-phonon resulting from electron cooling has a lifetime four to eight orders of magnitude above all the known value in semiconductors for this process. We finally show the suitability of SiSn for hot-carrier solar cells, as it is endowed with ultra-slow cooling of hot carriers.

Levard, Hugo; Laribi, Sana; Guillemoles, Jean-François [Institute for Research and Development on Photovoltaic Energy (IRDEP), UMR 7174, EDF R and D/CNRS/Chimie ParisTech, 6 quai Watier, 78401 Chatou (France)

2014-06-02T23:59:59.000Z

254

Precision lifetime measurements of a single trapped ion with ultrafast laser pulses  

E-Print Network [OSTI]

We report precision measurements of the excited state lifetime of the $5p$ $^2P_{1/2}$ and $5p$ $^2P_{3/2}$ levels of a single trapped Cd$^+$ ion. The ion is excited with picosecond laser pulses from a mode-locked laser and the distribution of arrival times of spontaneously emitted photons is recorded. The resulting lifetimes are 3.148 $\\pm$ 0.011 ns and 2.647 $\\pm$ 0.010 ns for $^2P_{1/2}$ and $^2P_{3/2}$ respectively. With a total uncertainty of under 0.4%, these are among the most precise measurements of any atomic state lifetimes to date.

D. L. Moehring; B. B. Blinov; D. W. Gidley; R. N. Kohn Jr.; M. J. Madsen; T. D. Sanderson; R. S. Vallery; C. Monroe

2005-05-15T23:59:59.000Z

255

Dependence of nuclear spin singlet lifetimes on RF spin-locking power  

E-Print Network [OSTI]

We measure the lifetime of long-lived nuclear spin singlet states as a function of the strength of the RF spin-locking field and present a simple theoretical model that agrees well with our measurements, including the low-RF-power regime. We also measure the lifetime of a long-lived coherence between singlet and triplet states that does not require a spin-locking field for preservation. Our results indicate that for many molecules, singlet states can be created using weak RF spin-locking fields: more than two orders of magnitude lower RF power than in previous studies. Our findings suggest that in many biomolecules, singlets and related states with enhanced lifetimes might be achievable in vivo with safe levels of RF power.

Stephen J. DeVience; Ronald L. Walsworth; Matthew S. Rosen

2012-01-06T23:59:59.000Z

256

1 888 939 3333 | cancer.ca Cancer Statistics  

E-Print Network [OSTI]

1 888 939 3333 | cancer.ca Canadian Cancer Statistics 2013 Special topic: Liver cancer Produced by Canadian Cancer Society, Statistics Canada, Public Health Agency of Canada, Provincial/Territorial Cancer Registries cancer.ca/statistics #12;2Canadian Cancer Society n Canadian Cancer Statistics 2013 Citation

Habib, Ayman

257

The Lifetime Estimate for ACSR Single-Stage Splice Connector Operating at Higher Temperatures  

SciTech Connect (OSTI)

This paper is the continuation of Part I effort to develop a protocol of integrating analytical and experimental approaches to evaluate the integrity of a full tension single-stage splice connector (SSC) assembly during service at high operating temperature.1The Part II efforts are mainly focused on the thermal mechanical testing, thermal-cycling simulation and its impact on the effective lifetime of the SSC system. The investigation indicates that thermal cycling temperature and frequency, conductor cable tension loading, and the compressive residual stress field within a SSC system have significant impact on the SSC integrity and the associated effective lifetime.

Wang, Jy-An John [ORNL; Graziano, Joe [Tennessee Valley Authority (TVA); Chan, John [Electric Power Research Institute (EPRI)

2011-01-01T23:59:59.000Z

258

The Effective Lifetime of ACSR Full Tension Splice Connector Operated at Higher Temperature  

SciTech Connect (OSTI)

This paper is to address the issues related to integrity of ACSR full tension splice connectors operated at high temperatures. A protocol of integrating analytical and experimental approaches to evaluate the integrity of a full tension single-stage splice connector (SSC) assembly during service at high operating temperature was developed. Based on the developed protocol the effective lifetime evaluation was demonstrated with ACSR Drake conductor SSC systems. The investigation indicates that thermal cycling temperature and frequency, conductor cable tension loading, and the compressive residual stress field within a SSC system have significant impact on the SSC integrity and the associated effective lifetime.

Wang, Jy-An John [ORNL] [ORNL; Lara-Curzio, Edgar [ORNL] [ORNL; King Jr, Thomas J [ORNL] [ORNL; Graziano, Joe [Tennessee Valley Authority (TVA)] [Tennessee Valley Authority (TVA); Chan, John [Electric Power Research Institute (EPRI)] [Electric Power Research Institute (EPRI); Goodwin, Tip [PBS& J] [PBS& J

2009-01-01T23:59:59.000Z

259

Nuclear matrix elements from direct lifetime or cross-section measurements  

SciTech Connect (OSTI)

The method of simultaneous lifetime and g factor measurements using a plunger device and the RDDS and TDRIV techniques is introduced. Results on lifetimes and hyperfine-interaction parameters for 2{sup +}{sub 1} states in {sup 104-108}Pd, {sup 96,98,104}Ru, and {sup 92,94}Zr, using a plunger device. Another method to obtain electromagnetic matrix elements is direct cross section measurements using NRF. The method is outlined, and some recent results on {sup 76}Se are shown.

Werner, V.; Cooper, N.; Hinton, M.; Ilie, G.; Radeck, D. [Wright Nuclear Structure Laboratory, Yale University, P.O. Box 208120, New Haven, CT 06520-8120 (United States); Wright Nuclear Structure Laboratory, Yale University, P.O. Box 208120, New Haven, CT 06520-8120 (United States) and Department of Physics, University of Surrey, Guilford, GU27XH (United Kingdom); Wright Nuclear Structure Laboratory, Yale University, P.O. Box 208120, New Haven, CT 06520-8120 (United States) and National Institute for Physics and Nuclear Engineering, P.O. Box MG-6, Bucharest-Magurele (Romania); Wright Nuclear Structure Laboratory, Yale University, P.O. Box 208120, New Haven, CT 06520-8120 (United States) and Institut fuer Kernphysik, Universitaet zu Koeln, Zuelpicher Str. 77, 50937 Koeln (Germany)

2012-11-20T23:59:59.000Z

260

Reporting on the lifetime of charmless B/s meson decay to K+ K-  

SciTech Connect (OSTI)

The authors use data collected by the displaced track trigger of the CDF Run II detector at TeVatron to measure the B mesons lifetime in the hadronic decays: B{sub u} {yields} D{sup 0}{pi}, B{sub d} {yields} D{sup {-+}}{pi}{sup {+-}}, B{sub d} {yields} D{sup {-+}}3{pi}, B{sub s} {yields} D{sub s}{sup {-+}}{pi}{sup {+-}}, B{sub s} {yields} D{sub s}{sup {-+}}3{pi}. Recent developments in the measurement of the lifetime of the charmless B{sub s} {yields} K{sup +}k{sup -} mode is presented.

Donega, M.; /Geneva U.

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PL LDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN  

E-Print Network [OSTI]

BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PL LDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN BUILDING A R RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN BUILDIN T PLAN BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEM

Florida, University of

262

Enterprise Risk Management Framework  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Framework The Enterprise Risk Management (ERM) framework includes four steps: identify the risks, determine the probability and impact of each one, identify controls that are...

263

Cigarettes Health Risks  

E-Print Network [OSTI]

those around you: Quitting will help protect your friends and family from the dangers of second hand of a smokingrelated illness. Smoking not only harms your lungs, it negatively affects nearly every organ in the body. Smoking is the leading cause of cancer, and leads to the most deaths from cancer. These cancers include

Oregon, University of

264

Seminars in Cancer Biology 14 (2004) 413426 Role and limitations of epidemiology in establishing a causal association  

E-Print Network [OSTI]

Seminars in Cancer Biology 14 (2004) 413­426 Role and limitations of epidemiology in establishing MD Anderson Cancer Center, Houston, TX, USA e Department of Biostatistics, Bloomberg School of Public Clinic College of Medicine, Rochester, MN, USA Abstract Cancer risk assessment is one of the most visible

Barthelat, Francois

265

A METHODOLOGY FOR THE CONTROL OF THE RESIDUAL LIFETIMES OF CARBON FIBRE  

E-Print Network [OSTI]

on composite materials, France (2005)" #12;carbon fibre composites are considered by these authors as beingA METHODOLOGY FOR THE CONTROL OF THE RESIDUAL LIFETIMES OF CARBON FIBRE REINFORCED COMPOSITE of their loading history with precision. KEYWORDS: pressure vessels, carbon fibre composites, life time prediction

Boyer, Edmond

266

Sensor Node Lifetime Analysis: Models and Tools Deokwoo Jung, Thiago Teixeira, Andreas Savvides  

E-Print Network [OSTI]

decisions, compute energy budgets and duty-cycles, and to preform side-by-side comparison of different's average lifetime for a given event arrival rate. Through comparison of the two models and a case study & Simulation Package (MATSNL). This demonstrates the use of the models using sample applications drawn from

Teixeira, Thiago

267

Feasibility of Underwater Sensor Networks for Lifetime Assessment of Offshore Civil Structures  

E-Print Network [OSTI]

Feasibility of Underwater Sensor Networks for Lifetime Assessment of Offshore Civil Structures is to investigate the feasibility of underwater sensor networks for offshore and deep-sea structural monitoring. In this paper, the network communication topology and in-network processing algorithm for two offshore wind

Zhou, Shengli

268

Sensor Network Lifetime Maximization Via Sensor Energy Balancing: Construction and Optimal Scheduling of Sensor Trees  

E-Print Network [OSTI]

in such a way that the total energy usage of the active sensor nodes in the tree is minimized. However whenSensor Network Lifetime Maximization Via Sensor Energy Balancing: Construction and Optimal Scheduling of Sensor Trees Ling Shi , Agostino Capponi , Karl H. Johansson and Richard M. Murray Abstract

Johansson, Karl Henrik

269

Minimizing Energy and Maximizing Network Lifetime Multicasting in Wireless Ad Hoc Networks  

E-Print Network [OSTI]

trees with multiple optimization objectives. A. Related Work A number of energy-aware broadcast] that the problem of finding a minimum-energy broadcast tree is NP-hard. Particularly in [2], they have shownMinimizing Energy and Maximizing Network Lifetime Multicasting in Wireless Ad Hoc Networks Weifa

Liang, Weifa

270

The average person sheds 40 pounds of skin during his or her lifetime. That's the  

E-Print Network [OSTI]

Q: MSU N 19 o. The average person sheds 40 pounds of skin during his or her lifetime. That whether they are facts or opinions. Fact or opinion? A fact is something that can be tested. An opinion is something that someone thinks or believes. 1. Wooly mammoths are extinct. fact opinion 2. Ear wax can

271

Shirokov's contracting lifetimes and the interpretation of velocity eigenstates for unstable quantons  

E-Print Network [OSTI]

This paper is concerned with the interpretation of velocity eigenstates for unstable quantons, their relationship to space like momentum eigenstates for such quantons and the explanation of Shirokovs contracting lifetimes for such velocity eigenstates. It is an elaboration of a portion of the authors earlier study.

Gordon N. Fleming

2009-11-02T23:59:59.000Z

272

Development of a high average current polarized electron source with long cathode operational lifetime  

SciTech Connect (OSTI)

Substantially more than half of the electromagnetic nuclear physics experiments conducted at the Continuous Electron Beam Accelerator Facility of the Thomas Jefferson National Accelerator Facility (Jefferson Laboratory) require highly polarized electron beams, often at high average current. Spin-polarized electrons are produced by photoemission from various GaAs-based semiconductor photocathodes, using circularly polarized laser light with photon energy slightly larger than the semiconductor band gap. The photocathodes are prepared by activation of the clean semiconductor surface to negative electron affinity using cesium and oxidation. Historically, in many laboratories worldwide, these photocathodes have had short operational lifetimes at high average current, and have often deteriorated fairly quickly in ultrahigh vacuum even without electron beam delivery. At Jefferson Lab, we have developed a polarized electron source in which the photocathodes degrade exceptionally slowly without electron emission, and in which ion back bombardment is the predominant mechanism limiting the operational lifetime of the cathodes during electron emission. We have reproducibly obtained cathode 1/e dark lifetimes over two years, and 1/e charge density and charge lifetimes during electron beam delivery of over 2?105???C/cm2 and 200 C, respectively. This source is able to support uninterrupted high average current polarized beam delivery to three experimental halls simultaneously for many months at a time. Many of the techniques we report here are directly applicable to the development of GaAs photoemission electron guns to deliver high average current, high brightness unpolarized beams.

C. K. Sinclair; P. A. Adderley; B. M. Dunham; J. C. Hansknecht; P. Hartmann; M. Poelker; J. S. Price; P. M. Rutt; W. J. Schneider; M. Steigerwald

2007-02-01T23:59:59.000Z

273

LIFETIME OF THE EXCITED STATE IN VIVO I. CHLOROPHYLL a IN ALGAE, AT ROOM  

E-Print Network [OSTI]

LIFETIME OF THE EXCITED STATE IN VIVO I. CHLOROPHYLL a IN ALGAE, AT ROOM AND AT LIQUID NITROGEN decay of chloro- phyll (Chl) a in the green alga Chlorella pyrenoidosa, the red alga Porphyridium cruentum, and the blue-green alga Anacystis nidulans was measured by the phase- shift method under

Govindjee

274

Lifetime Behavior and its Impact on Web Caching Xiangping Chen and Prasant Mohapatra  

E-Print Network [OSTI]

Lifetime Behavior and its Impact on Web Caching Xiangping Chen and Prasant Mohapatra Department@iastate.edu Abstract The exponential growth of the World Wide Web has made it the most popular information on the web to al­ leviate the web server load, conserve the network band­ width, and reduce the retrieval

Mohapatra, Prasant

275

Lifetime Assessment for Thermal Barrier Coatings: Tests for Measuring Mixed Mode Delamination Toughness  

E-Print Network [OSTI]

the thermally grown oxide (TGO), and a porous ceramic topcoat which serves as the thermal insulation. DetailsLifetime Assessment for Thermal Barrier Coatings: Tests for Measuring Mixed Mode Delamination Mechanisms leading to degradation of the adherence of thermal barrier coatings (TBC) used in aircraft

Hutchinson, John W.

276

A Hybrid Solid-State Storage Architecture for the Performance, Energy Consumption, and Lifetime Improvement  

E-Print Network [OSTI]

A Hybrid Solid-State Storage Architecture for the Performance, Energy Consumption, and Lifetime-place updating so that it significantly im- proves the usage efficiency of log pages by eliminating out- of results show that our proposed methods can substantially improve the perfor- mance, energy consumption

Giles, C. Lee

277

Extending the Lifetime of Media Recorders Constrained by Battery and Flash Memory Size  

E-Print Network [OSTI]

balancing the energy consumption and the flash memory usage. The proposed method can be effectively employed recorders that signifi- cantly enhances their lifetime while minimizing the flash memory usage.3 [Microcomputers]: Portable devices (e.g., laptops, personal digital assistants) General Terms Design, Performance

Kambhampati, Subbarao

278

Lifetime of the Bose Gas with Resonant Interactions B. S. Rem,1  

E-Print Network [OSTI]

Lifetime of the Bose Gas with Resonant Interactions B. S. Rem,1 A. T. Grier,1 I. Ferrier-Barbut,1 U at and around unitarity using a Feshbach resonance in lithium 7. At unitarity, we measure the temperature length a describing two-body interactions becomes infinite. It has been demonstrated both experimentally

279

Re-evaluation of the lifetimes of the major CFCs and CH3  

E-Print Network [OSTI]

Re-evaluation of the lifetimes of the major CFCs and CH3 CCl3 using atmospheric trends* M. Rigby, R interactions among natural and human climate system components; objectively assess uncertainty in economic, monitor and verify greenhouse gas emissions and climatic impacts. This reprint is one of a series intended

280

Photoconductive Decay Lifetime and Suns-Voc Diagnostics of Efficient Heterojunction Solar Cells: Preprint  

SciTech Connect (OSTI)

We report results of minority carrier lifetime measurements for double-sided p-type Si heterojunction devices and compare Suns-Voc results to Light I-V measurements on 1 cm2 solar cell devices measured on an AM1.5 calibrated XT-10 solar simulator.

Page, M. R.; Iwaniczko, E.; Xu, Y.; Roybal L.; Bauer, R.; Yan, H.-C.; Wang, Q.; Meier, D. L.

2008-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Precision Measurement of the Mass and Lifetime of the ?[? over b] Baryon  

E-Print Network [OSTI]

We report on measurements of the mass and lifetime of the ?[- over b] baryon using about 1800 ?[- over b] decays reconstructed in a proton-proton collision data set corresponding to an integrated luminosity of 3.0??fb[superscript ...

Aaij, R.

282

STUDY OF CLOUD LIFETIME EFFECTS USING THE SGP HETEROGENEOUS DISTRIBUTED RADAR NETWORK: PRELIMINARY CONSIDERATIONS  

E-Print Network [OSTI]

STUDY OF CLOUD LIFETIME EFFECTS USING THE SGP HETEROGENEOUS DISTRIBUTED RADAR NETWORK: PRELIMINARY-dimensional morphology and life cycle of clouds. Detailing key cloud processes as they transit from the formation stage to precipitation onset and cloud dissipation is critical towards establishing uncertainties in climate models

283

Exploring the Multicast Lifetime Capacity of WANETs with Directional Multibeam Antennas  

E-Print Network [OSTI]

Columbia Vancouver, Canada leung@ece.ubc.ca Abstract--We explore the multicast lifetime capacity of energy a given task. Because energy supplied by batteries is likely to be scarce and non-renewable resource approaches for energy saving in WANETs. This is because directional communications can save transmission

Guo, Minyi

284

Distributed Algorithms for Lifetime Maximization in Sensor Networks via Min-Max  

E-Print Network [OSTI]

of the network and edges between nodes within maximum transmission range. Although the problem can in principle.lastname@tkk.fi Abstract We consider the problem of static transmission-power assignment for lifetime maximization to forward the collected data, at what intervals, transmission power levels, etc. One important goal

Orponen, Pekka

285

Alternative Size and Lifetime Measurements for High-Energy Heavy-Ion Collisions  

E-Print Network [OSTI]

Two-Particle correlations based on the interference of identical particles has provided the chief means for determining the shape and lifetime of sources in relativistic heavy ion collisions. Here, Strong and Coulomb induced correlations are shown to provide equivalent information.

Scott Pratt; Silvio Petriconi

2003-06-16T23:59:59.000Z

286

Near Infrared Dyes as Lifetime Solvatochromic Probes for Micropolarity Measurements of Biological Systems  

E-Print Network [OSTI]

Near Infrared Dyes as Lifetime Solvatochromic Probes for Micropolarity Measurements of Biological, metabolism, and excretion. With the recent widespread use of near-infrared (NIR) fluorescent dyes, ultraviolet/visible/near-infrared (NIR) absorption, and fluorescence (7,8) have been developed. The latter

Larson-Prior, Linda

287

Investigation on the performance of airliner cabin air filter throughout the lifetime usage  

E-Print Network [OSTI]

of Pollution Control and Resource Reuse, Tongji University, 1239 Siping Road, Shanghai, China 200092 2 School' exposure to particulate pollutants, most of aircraft environmental control systems have been installed1 Investigation on the performance of airliner cabin air filter throughout the lifetime usage Bin

Chen, Qingyan "Yan"

288

Lifetime Optimization of Multi-hop Wireless Sensor Networks by Regulating the Frequency of Use of  

E-Print Network [OSTI]

of Cooperative Transmission Jin Woo Jung and Mary Ann Ingram School of Electrical and Computer EngineeringLifetime Optimization of Multi-hop Wireless Sensor Networks by Regulating the Frequency of Use model, we show how Cooperative Transmission (CT), when it is used to extend the communication range, can

Ingram, Mary Ann

289

Kinetics of the photoreactions of some organic free radicals and lifetimes of electronically excited states  

SciTech Connect (OSTI)

The lifetimes of electronically excited states of the antraquinone radical anion and of the stable 1,3-bisdiphenylene-2-phenylallyl (DPPA) radical during their photoreactions with organic solvents have been evaluated by analyzing kinetic curves. The results obtained suggest that the anthraquinone radical anion undergoes a photoreaction in a quartet state, while DPPA does so in one of the higher doublet states.

Oginets, V.Ya.

1986-04-01T23:59:59.000Z

290

Electron generation of leptons and hadrons with reciprocal -quantized lifetimes and masses  

E-Print Network [OSTI]

1 Electron generation of leptons and hadrons with reciprocal -quantized lifetimes and masses generation occurs via an initial "-leap" from an electron pair to a "platform state" M, and then subsequent in the generation of hadron masses. In fact, the role of the electron in generating lepton masses has never been

291

Assessing node risk and vulnerability in epidemics on networks  

E-Print Network [OSTI]

Which nodes are most vulnerable to an epidemic spreading through a network, and which carry the highest risk of causing a major outbreak if they are the source of the infection? Here we show how these questions can be answered to good approximation using the cavity method. Several curious properties of node vulnerability and risk are explored: some nodes are more vulnerable than others to weaker infections, yet less vulnerable to stronger ones; a node is always more likely to be caught in an outbreak than it is to start one, except when the disease has a deterministic lifetime; the rank order of node risk depends on the details of the distribution of infectious periods.

Rogers, Tim

2015-01-01T23:59:59.000Z

292

Extending the Lifetime of Fuel Cell Based Hybrid Systems* Jianli Zhuo1, Chaitali Chakrabartil, Naehyuck Chang2, Sarma Vrudhula3  

E-Print Network [OSTI]

34.1 Extending the Lifetime of Fuel Cell Based Hybrid Systems* Jianli Zhuo1, Chaitali Chakrabartil@asu.edu ABSTRACT for portable applications. Fuel cells have very high energy densities Fuel cells are clean power densities and lifetimes compared to batteries. However, fuel cells

Kambhampati, Subbarao

293

Wafer Preparation and Iodine-Ethanol-Ethanol Passivation Procedure for Reproducible Minority-Carrier Lifetime Measurement: Preprint  

SciTech Connect (OSTI)

This paper describes reasons that lifetime measurments may be irreproducible using iodine-in-ethanol (I-E) passivation. Possible factors include the strength of the iodine in ethanol solution, wafer cleaning procedures, influence of wafer container during lifetime measurement, and stability of I-E.

Sopori, B.; Rupnowski, P.; Appel, J.; Mehta, V.; Li, C.; Johnston, S.

2008-05-01T23:59:59.000Z

294

Predicting the Remaining Useful Lifetime of a Proton Exchange Membrane Fuel Cell using an Echo State Network  

E-Print Network [OSTI]

1 Predicting the Remaining Useful Lifetime of a Proton Exchange Membrane Fuel Cell using an Echo industrial Fuel Cell (FC) application resides in the system limited useful lifetime. Consequently, it Membrane Fuel Cell using an iterative predictive structure, which is the most common approach performing

Boyer, Edmond

295

Global Climate & Catastrophic Risk  

E-Print Network [OSTI]

Global Climate & Catastrophic Risk Forum 2012 A Joint Program with LA RIMS Education Day Rethinking Catastrophic Risk in Risk Management: Earthquake-Related Challenges Featuring: Keynote Speaker Dr. Frank Beuthin, Willis Group Holdings Plc. Yohei Miyamoto, Aon Risk Solutions Curtis deVera, Marsh

de Lijser, Peter

296

The National Cancer Institute,  

E-Print Network [OSTI]

The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

297

CANCER BIOLOGY Infectioustumourcells  

E-Print Network [OSTI]

CANCER BIOLOGY Infectioustumourcells David Dingli and Martin A. Nowak Cancer cells are generally infectious agents and be transmitted between individuals. The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer- promoting

Nowak, Martin A.

298

Cancer mortality and residence near petrochemical industries in Taiwan  

SciTech Connect (OSTI)

An ecologic study design was used to investigate the relationship between cancer risks and residence in communities adjacent to petrochemical industrial counties (PICs). Directly age-adjusted mortality rates for cancer during 1982-1991 among 16 counties characterized by a heavy concentration of petrochemical industries were compared to rates among 16 matched counties with similar concentration of nonpetrochemical manufacturing industries, urbanization level, and demographic characteristics. An excess rate for liver cancer among males was found in the so-called PICs. The correlation could not be explained by confounding variables such as urbanization, socioeconomic class, or employment in nonpetrochemical industries. No other increased cancer risks were found to be associated with residence near petrochemical industries. 30 refs., 3 tabs.

Yang, Chun-Yuh; Chiu, Hui-Fen; Chiu, Jeng-Fen [Kaohsiung Medical College (Taiwan, Province of China)] [and others

1997-02-21T23:59:59.000Z

299

Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.  

E-Print Network [OSTI]

Abstract Introduction Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles...

Mulligan, Anna Marie; Couch, Fergus J; Barrowdale, Daniel; Domchek, Susan M; Eccles, Diana; Nevanlinna, Heli; Ramus, Susan J; Robson, Mark; Sherman, Mark; Spurdle, Amanda B; Wappenschmidt, Barbara; Antoniou, Antonis C; Family Registry, Breast Cancer; Embrace, .; Collaborators, GEMO Study; Hebon, .; Network, Ontario Cancer Genetics; Swe-brca, .; Cimba, .; Osorio, Ana; Munoz-Repeto, Ivan; Coupier, Isabelle; Duran, Mercedes; Godino, Javier; Pertesi, Maroulio; Benitez, Javier; Peterlongo, Paolo; Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Cattaneo, Elisa; Bonanni, Bernardo; Lebrun, Marine; Viel, Alessandra; Pasini, Barbara; Papi, Laura; Ottini, Laura; Savarese, Antonella; Bernard, Loris; Radice, Paolo; Hamann, Ute; Verheus, Martijn; Meijers-Heijboer, Hanne EJ; Kientz, Caroline; Wijnen, Juul; Gomez Garcia, Encarna B; Nelen, Marcel R; Kets, C Marleen; Seynaeve, Caroline; Tilanus-Linthorst, Madeleine MA; van der Luijt, Rob B; van Os, Theo; Rookus, Matti; Frost, Debra; Longy, Michel; Jones, J Louise; Evans, D Gareth; Lalloo, Fiona; Eeles, Ros; Izatt, Louise; Adlard, Julian; Davidson, Rosemarie; Cook, Jackie; Donaldson, Alan; Dorkins, Huw; Sevenet, Nicolas; Gregory, Helen; Eason, Jacqueline; Houghton, Catherine; Barwell, Julian; Side, Lucy E; McCann, Emma; Murray, Alex; Peock, Susan; Godwin, Andrew; Schmutzler, Rita K; Stoppa-Lyonnet, Dominique; Rhiem, Kerstin; Engel, Christoph; Meindl, Alfons; Ruehl, Ina; Arnold, Norbert; Niederacher, Dieter; Sutter, Christian; Deissler, Helmut; Gadzicki, Dorothea; Kast, Karin; Isaacs, Claudine; Preisler-Adams, Sabine; Varon-Mateeva, Raymonda; Schoenbuchner, Ines; Fiebig, Britta; Heinritz, Wolfram; Schafer, Dieter; Gevensleben, Heidrun; Caux-Moncoutier, Virginie; Fassy-Colcombet, Marion; Cornelis, Francois; Caldes, Trinidad; Mazoyer, Sylvie; Leone, Melanie; Boutry-Kryza, Nadia; Hardouin, Agnes; Berthet, Pascaline; Muller, Daniele; Fricker, Jean-Pierre; Mortemousque, Isabelle; Pujol, Pascal; de al Hoya, Miguel; Heikkinen, Tuomas; Lee, Andrew; Aittomaki, Kristiina; Blanco, Ignacio; Lazaro, Conxi; Barkardottir, Rosa B; Soucy, Penny; Dumont, Martine; Simard, Jacques; Montagna, Marco; Tognazzo, Silvia; D'Andrea, Emma; McGuffog, Lesley; Fox, Stephen; Yan, Max; Rebbeck, Timothy R; Olopade, Olufunmilayo I; Weitzel, Jeffrey N; Lynch, Henry T; Ganz, Patricia A; Tomlinson, Gail E; Wang, Xianshu; Fredericksen, Zachary; Healey, Sue; Pankratz, Vernon S; Lindor, Noralane M; Szabo, Csila; Offit, Kenneth; Sakr, Rita; Gaudet, Mia; Bhatia, Jasmine; Kauff, Noah; Singer, Christian F; Tea, Muy-Kheng; Sinilnikova, Olga M; Gschwantler-Kaulich, Daphne; Fink-Retter, Anneliese; Mai, Phuong L; Greene, Mark H; Imyanitov, Evgeny; O'Malley, Frances P; Ozcelik, Hilmi; Glendon, Gordon; Toland, Amanda E; Gerdes, Anne-Marie; Janavicius, Ramunas; Thomassen, Mads; Kruse, Torben A; Birk Jensen, Uffe; Skytte, Anne-Bine; Caligo, Maria A; Soller, Maria; Henriksson, Karin; von Wachenfeldt, Anna; Arver, Brita; Stenmark-Askmalm, Marie; Hansen, Thomas V O; Karlsson, Per; Ding, Yuan Chun; Neuhausen, Susan L; Beattie, Mary; Pharoah, Paul D P; Moysich, Kirsten B; Nathanson, Katherine L; Karlan, Beth Y; Gross, Jenny; John, Esther M; Nielsen, Finn C; Daly, Mary B; Buys, Saundra M; Southey, Melissa C; Hopper, John L; Terry, Mary Beth; Chung, Wendy; Miron, Alexander F; Goldgar, David; Chenevix-Trench, Georgia; Easton, Douglas F; Ejlertsen, Bent; Andrulis, Irene L

2011-11-02T23:59:59.000Z

300

CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER  

E-Print Network [OSTI]

CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

Sherman, S. Murray

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Franck-Condon factors, transition probabilities, and radiative lifetimes for hydrogen molecules and their isotopomeres  

SciTech Connect (OSTI)

stematic fundamental molecular database for all isotopomeres of the hydrogen molecule (H{sub 2}, D{sub 2}, T{sub 2}, HD, HT, DT) is calculated on the basis of the latest Born-Oppenheimer potential curves and the latest electronic dipole transition moments of hydrogen molecules. Vibrational eigenvalues, Franck-Condon factors, and vibrationally resolved transition probabilities are presented for electronic transitions in each multiplet system up to principal quantum number n = 4. Radiative lifetimes of the vibrational levels in the electronically excited states are obtained from the summation over the optically allowed transitions. In a similar manner, effective transition probabilities and effective radiative lifetimes of electronically excited states are determined assuming that only the lowest vibrational level in the ground state is populated, i.e. the data are directly applicable to molecular gases. Differences between the isotopomeres are discussed briefly.

Fantz, U. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Boltzmannstr. 2, D-85748 Garching (Germany)]. E-mail: fantz@ipp.mpg.de; Wuenderlich, D. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Boltzmannstr. 2, D-85748 Garching (Germany)

2006-11-15T23:59:59.000Z

302

Phosphazene Based Additives for Improvement of Safety and Battery Lifetimes in Lithium-Ion Batteries  

SciTech Connect (OSTI)

There need to be significant improvements made in lithium-ion battery technology, principally in the areas of safety and useful lifetimes to truly enable widespread adoption of large format batteries for the electrification of the light transportation fleet. In order to effect the transition to lithium ion technology in a timely fashion, one promising next step is through improvements to the electrolyte in the form of novel additives that simultaneously improve safety and useful lifetimes without impairing performance characteristics over wide temperature and cycle duty ranges. Recent efforts in our laboratory have been focused on the development of such additives with all the requisite properties enumerated above. We present the results of the study of novel phosphazene based electrolytes additives.

Mason K Harrup; Kevin L Gering; Harry W Rollins; Sergiy V Sazhin; Michael T Benson; David K Jamison; Christopher J Michelbacher

2011-10-01T23:59:59.000Z

303

Gamma-ray induced Doppler broadening and the determination of lifetimes of excited nuclear states  

SciTech Connect (OSTI)

Measurements of lifetimes of excited states in nuclei yield crucial information for sensitive tests of nuclear models. Here a novel method will be discussed which involves the GRID (Gamma Ray Induced Doppler broadening) technique, in which Doppler broadening is observed in a transition from a nucleus recoiling from the emission of a previous gamma ray. As the recoil energy is extremely small, ultra-high energy resolving power has to be used. To date all such experiments have been carried out at ILL using the GAMS4 double flat crystal spectrometer which is operated in a NIST-ILL collaboration. The method can be used for all lifetimes below a few picoseconds. The wide range of applicability, together with the very exhaustive set of data often obtained, is an advantage with respect to many other methods. The characteristic features of GRID will be discussed using some selected examples. 21 refs., 8 figs.

Boerner, H.G.; Jolie, J.; Robinson, S.J. (Institut Laue-Langevin, 38 - Grenoble (France)); Kessler, E.G.; Dewey, S.M.; Greene, G.; Deslattes, R. (National Inst. of Standards and Technology, Gaithersburg, MD (USA)); Ulbig, S.; Lieb, K.P. (Goettingen Univ. (Germany, F.R.)); Casten, R.F. (Brookhaven National Lab., Upton, NY (USA)); Krusche, B. (Giessen Univ. (Germany, F.R.)); Cizewski, J.A. (Rutgers--the

1990-01-01T23:59:59.000Z

304

Measurement of the Neutron Lifetime by Counting Trapped Protons in a Cold Neutron Beam  

E-Print Network [OSTI]

A measurement of the neutron lifetime $\\tau_{n}$ performed by the absolute counting of in-beam neutrons and their decay protons has been completed. Protons confined in a quasi-Penning trap were accelerated onto a silicon detector held at a high potential and counted with nearly unit efficiency. The neutrons were counted by a device with an efficiency inversely proportional to neutron velocity, which cancels the dwell time of the neutron beam in the trap. The result is $\\tau_{n} = (886.6\\pm1.2{\\rm [stat]}\\pm3.2{\\rm [sys]})$ s, which is the most precise measurement of the lifetime using an in-beam method. The systematic uncertainty is dominated by neutron counting, in particular the mass of the deposit and the $^{6}$Li({\\it{n,t}}) cross section. The measurement technique and apparatus, data analysis, and investigation of systematic uncertainties are discussed in detail.

J. S. Nico; M. S. Dewey; D. M. Gilliam; F. E. Wietfeldt; X. Fei; W. M. Snow; G. L. Greene; J. Pauwels; R. Eykens; A. Lamberty; J. Van Gestel; R. D. Scott

2004-11-19T23:59:59.000Z

305

Theory of SEI Formation in Rechargeable Batteries: Capacity Fade, Accelerated Aging and Lifetime Prediction  

E-Print Network [OSTI]

Cycle life is critically important in applications of rechargeable batteries, but lifetime prediction is mostly based on empirical trends, rather than mathematical models. In practical lithium-ion batteries, capacity fade occurs over thousands of cycles, limited by slow electrochemical processes, such as the formation of a solid-electrolyte interphase (SEI) in the negative electrode, which compete with reversible lithium intercalation. Focusing on SEI growth as the canonical degradation mechanism, we show that a simple single-particle model can accurately explain experimentally observed capacity fade in commercial cells with graphite anodes, and predict future fade based on limited accelerated aging data for short times and elevated temperatures. The theory is extended to porous electrodes, predicting that SEI growth is essentially homogeneous throughout the electrode, even at high rates. The lifetime distribution for a sample of batteries is found to be consistent with Gaussian statistics, as predicted by th...

Pinson, Matthew B

2012-01-01T23:59:59.000Z

306

Recombination Lifetime of InxGa1-xAs Alloys Used in Thermophotovoltaic Converters  

SciTech Connect (OSTI)

The family of ternary compounds of composition InxGa1-xAs are of considerable interest for thermophotovoltaic energy converters. The recombination lifetimes of the various compositions are critical to the successful application of these materials as efficient converters. Here we will describe experimental results on the composition. In0.53Ga0.47 that is lattice-matched to InP. We will also describe lifetime results on the compositions In0.68Ga0.32As, with bandgap of 0.60 eV to compositions In0.78Ga0.22As with a bandgap of 0.50 eV. Double heterostructure confinement devices have been made over a range of both n- and p-type doping. These results are preliminary, but the goal is to obtain the radiative and Auger recombination coefficients for the alloys in this composition range.

Ahrenkiel, R. K.; Ellingson, R.; Johnston, S.; Webb, J.; Carapella, J.; Wanlass, M.

1999-02-16T23:59:59.000Z

307

Measurement of the Lifetime of the B(±)(c) Meson in the Semileptonic Decay Channel  

E-Print Network [OSTI]

; published 2 March 2009) Using approximately 1:3 fb#2;1 of data collected by the D0 detector between 2002 and 2006, we measure the lifetime of the B#1;c meson in the B#1;c ! J=c#1;#1; þ X final state. A simultaneous unbinned likelihood fit to the J=c þ#1... weakly-decaying b hadrons. Examples of final states where the c quark acts as a spectator while the b quark decays weakly are B#1;c ! J=c#3;#1;, B#1;c ! J=cD#1;s , and B#1;c ! J=c ‘#1;#4;. In this Letter we present a measurement of the lifetime of the B#1...

Baringer, Philip S.; Bean, Alice; Clutter, Justace Randall; Moulik, Tania; Wilson, Graham Wallace

2009-03-02T23:59:59.000Z

308

Apparatus and method for measuring minority carrier lifetimes in semiconductor materials  

DOE Patents [OSTI]

An apparatus for determining the minority carrier lifetime of a semiconductor sample includes a positioner for moving the sample relative to a coil. The coil is connected to a bridge circuit such that the impedance of one arm of the bridge circuit is varied as sample is positioned relative to the coil. The sample is positioned relative to the coil such that any change in the photoconductance of the sample created by illumination of the sample creates a linearly related change in the input impedance of the bridge circuit. In addition, the apparatus is calibrated to work at a fixed frequency so that the apparatus maintains a consistently high sensitivity and high linearity for samples of different sizes, shapes, and material properties. When a light source illuminates the sample, the impedance of the bridge circuit is altered as excess carriers are generated in the sample, thereby producing a measurable signal indicative of the minority carrier lifetimes or recombination rates of the sample.

Ahrenkiel, Richard K. (Lakewood, CO); Johnston, Steven W. (Golden, CO)

2001-01-01T23:59:59.000Z

309

Risk assessment for organic micropollutants: U. S. point of view  

SciTech Connect (OSTI)

Basic research and monitoring of sludge utilization programs have identified specific pathways by which potentially toxic constituents of sewage sludge can reach and cause toxicity to livestock, humans, plants, soil biota, wildlife, etc. In the process of preparing a new regulation for land application of sewage sludge in the US, a pathway approach to risk assessment was undertaken. Two Pathways were found to comprise the greatest risk from persistent lipophilic organic compounds such as PCBs: (1) direct ingestion of sludge by children; and (2) adherence of sludge to forage/pasture crops from surface application of fluid sludge, followed by grazing and ingestion of sludge by livestock used as human food. Each pathway considers risk to Most Exposed Individuals (MEIs) who have high exposure to sludge. Because 1990 sewage sludges contain very low levels of PCBs, the estimated risk level to MEIs was less 0.0001, low sludge PCBs and low probability of simultaneously meeting all the constraints of the MEI indicate that MEIs are at less 0.0000001 lifetime risk. The authors conclude that quantitative risk assessment for potentially toxic constituents in sewage sludge can be meaningfully conducted because research has provided transfer coefficients from sludges and sludge-amended soils to plants and animals needed for many organic compounds.

Chaney, R.L.; Ryan, J.A.; O'Connor, G.A.

1991-01-01T23:59:59.000Z

310

Lifetime of oil drops pressed by buoyancy against a planar interface: Large drops  

E-Print Network [OSTI]

In a previous report [10] it was shown that emulsion stability simulations are able to reproduce the lifetime of micrometer-size drops of hexadecane pressed by buoyancy against a planar water-hexadecane interface. It was confirmed that small drops (rioil stabilized with bovine serum albumin. The potential obtained is then employed to study the lifetime of deformable drops in the range 10 \\leq ri \\leq 1000 {\\mu}m. It is established that the average lifetime of these drops can be adequately replicated using the model of truncated spheres. However, the results depend sensibly on the expressions of the initial distance of deformation and the maximum film radius used in the calculations. The set of equations adequate for large drops is not satisfactory for medium-size drops (10 \\leq ri \\leq 100 {\\mu}m), and vice versa. In the case of large particles, the increase in the interfacial area as a consequence of the deformation of the drops generates a very large repulsive barrier which opposes coalescence. Nevertheless, the buoyancy force prevails. As a consequence, it is the hydrodynamic tensor of the drops which determine the characteristic behavior of the lifetime as a function of the particle size. While the average values of the coalescence time of the drops can be justified by the mechanism of film thinning, the scattering of the experimental data of large drops cannot be rationalized using the methodology previously described. A possible explanation of this phenomenon required elaborate simulations which combine deformable drops, capillary waves, repulsive interaction forces, and a time-dependent surfactant adsorption.

Clara Rojas; Máximo García-Sucre; Germán Urbina-Villalba

2011-09-22T23:59:59.000Z

311

Comparison of Accelerated Testing with Modeling to Predict Lifetime of CPV Solder Layers (Presentation)  

SciTech Connect (OSTI)

Concentrating photovoltaic (CPV) cell assemblies can fail due to thermomechanical fatigue in the die-attach layer. In this presentation, we show the latest results from our computational model of thermomechanical fatigue. The model is used to estimate the relative lifetime of cell assemblies exposed to various temperature histories consistent with service and with accelerated testing. We also present early results from thermal cycling experiments designed to help validate the computational model.

Silverman, T. J.; Bosco, N.; Kurtz, S.

2012-03-01T23:59:59.000Z

312

Lifetime performance of Brahman-Hereford crossbred calves influenced by environment and preweaning stocking rates  

E-Print Network [OSTI]

as to style and content by: J. W. Turner (Chair of Committee) F. M. ouq ett, (Men ber W, L. Mies (Member) R. L. Edwards (Head of Department) December 1992 ABSTRACT Lifetime Performance of Brahman-Hereford Crossbred Calves Influenced by Environment... effects when additional nutrition was provided through creep feeding (15 ~ 3 kg). Additional creep feeding effects have been documented by (Prichard et al. , 1983; Martin et al. , 1981, 1977; Stricker et al. , 1979 and Holloway and Totusek, 1973...

Harris, Billy Todd

2012-06-07T23:59:59.000Z

313

Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer  

E-Print Network [OSTI]

The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors.1 To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we ...

Green, Todd

314

Metabolic Syndrome, Vitamin D Status, and the Incidence of Prostate Cancer  

E-Print Network [OSTI]

ABSTRACT Background: Epidemiologic data on the role of metabolic syndrome on prostate cancer risk is inconsistent, and only one case-control trial has examined the combined relationship of metabolic syndrome and vitamin D deficiency. Objective...

Rorabaugh, Joseph Randall

2012-08-31T23:59:59.000Z

315

Measurement of D0 lifetime with the BaBar detector  

SciTech Connect (OSTI)

This work is the result of the researchers carried out during a three years Ph.D. period in the BABAR experiment. The first chapter consists in an introduction to the theoretical aspects of the D{sup 0} meson lifetime determination and CP violation parameters, as well as an overview of the CP violation in the B sector, which is the main topic of the experiment. The description of the experimental apparatus follows with particular attention to the Silicon Vertex Tracker detector, the most critical detector for the determination of decay vertices and thus of lifetimes and time dependent CP violation asymmetries. In the fourth chapter the operation and running of the vertex detector is described, as a result from the experience as Operation Manager of the SVT, with particular attention to the safety of the device and the data quality assurance. The last chapter is dedicated to the determination of the D{sup 0} meson lifetime with the BABAR detector, which is the main data analysis carried out by the candidate. The analysis is characterized by the selection of an extremely pure sample of D{sup 0} mesons for which the decay flight length and proper time is reconstructed. The description of the unbinned maximum likelihood fit follows, as well as the discussion of the possible sources of systematic uncertainties. In the appendix is also presented a preliminary study of a possible development regarding the determination of mixing and CP violation parameters for the D{sup 0} meson.

Simi, Gabriele; /Pisa U. /SLAC

2009-12-17T23:59:59.000Z

316

Effects of impurity atoms and molecules on the lifetime of antiprotonic helium atoms  

E-Print Network [OSTI]

Delayed annihilation time spectra of antiprotons (DATS) in room temperature helium gas have been studied as a function of the concentration of admixed noble gases (Ne, Ar, Kr, Xe) as well as molecular gases (N_2,O_2,H_2) at the low energy antiproton ring (LEAR) at CERN. The DATS were a superposition of two exponential components, one with lifetime of several 100 ns and the other with lifetime 1 to 3 \\mus. They showed a shorter average lifetime (T_{av}) than DATS of pure helium. Ne, Ar, and Kr were found to affect T_{av} only slightly even in concentrations up to 20\\%, while Xe showed a much stronger influence. In the case of molecular gases the presence of N_2 influenced the DATS much less than O_2 and H_2 which destroyed the metastability almost completely in concentrations of 100 ppm and less. The decay rate of the slow component of DATS was found to exhibit a linear relation to the number density of the admixture. From this a collisional destruction (``quenching'') cross section \\sigma_q was extracted. No ...

Widmann, E; Yamazaki, T; Hayano, R S; Iwasaki, M; Nakamura, S N; Tamura, H; Ito, T M; Kawachi, A; Nishida, N; Higemoto, M; Ito, Y; Morita, N; Hartmann, F J; Daniel, H; Von Egidy, T; Schmid, W; Hoffmann, J; Eades, John

1996-01-01T23:59:59.000Z

317

Measurement of the $B^-$ lifetime using a simulation free approach for trigger bias correction  

SciTech Connect (OSTI)

The collection of a large number of B hadron decays to hadronic final states at the CDF II detector is possible due to the presence of a trigger that selects events based on track impact parameters. However, the nature of the selection requirements of the trigger introduces a large bias in the observed proper decay time distribution. A lifetime measurement must correct for this bias and the conventional approach has been to use a Monte Carlo simulation. The leading sources of systematic uncertainty in the conventional approach are due to differences between the data and the Monte Carlo simulation. In this paper they present an analytic method for bias correction without using simulation, thereby removing any uncertainty between data and simulation. This method is presented in the form of a measurement of the lifetime of the B{sup -} using the mode B{sup -} {yields} D{sup 0}{pi}{sup -}. The B{sup -} lifetime is measured as {tau}{sub B{sup -}} = 1.663 {+-} 0.023 {+-} 0.015 ps, where the first uncertainty is statistical and the second systematic. This new method results in a smaller systematic uncertainty in comparison to methods that use simulation to correct for the trigger bias.

Aaltonen, T.; /Helsinki Inst. of Phys.; Adelman, J.; /Chicago U., EFI; Alvarez Gonzalez, B.; /Cantabria Inst. of Phys.; Amerio, S.; /INFN, Padua; Amidei, D.; /Michigan U.; Anastassov, A.; /Northwestern U.; Annovi, A.; /Frascati; Antos, J.; /Comenius U.; Apollinari, G.; /Fermilab; Appel, J.; /Fermilab; Apresyan, A.; /Purdue U. /Waseda U.

2010-04-01T23:59:59.000Z

318

Constraining the Lifetime of QSOs with Present-day Mass Function of Supermassive Black Holes  

E-Print Network [OSTI]

Using the theoretical models of the QSO formation, we can reproduce optical QSO luminosity functions (LFs) at high redshifts (z > 2.2). Two different models can reproduce LFs successfully, though the lifetime of QSOs, t_Q, and the relation between the black hole mass and the host halo mass are different each other; t_Q = 10^6yr, in one model, t_Q > 10^7yr, in other models. Here, we propose a method to break this degeneracy. We calculate the mass function of supermassive black holes (SMBHs) at z=2.5, and compare the result with the current mass function obtained by Salucci et al.(1999). In the shorter lifetime model, the mass function at z=2.5 exceeds that of z=0.0 by one order of magnitude, then it should be ruled out. We conclude that the lifetime is at least t_Q > 10^7yr. Next, we examine the difference of the formation epoch of SMBHs existing at z=3.0 for each model under the model assumptions. We simply discuss the difference of formation epoch as another possible model-discriminator.

T. Hosokawa

2002-05-13T23:59:59.000Z

319

Stress-temperature-lifetime response of nicalon fiber-reinforced SiC composites in air  

SciTech Connect (OSTI)

Time-to-failure tests were conducted in four-point flexure and in air as a function of stress levels and temperatures to study the lifetime response of various Nicalon fiber-reinforced SiC (designated as Nic/SiC) composites with a graphitic interfacial coating. The results indicated that all of the Nic/SiC composites exhibit a similar stress-dependent failure at applied stress greater than a threshold value. In this case, the lifetimes of the composites increased with decrease in both stress level and test temperature. The lifetime of the composites appeared to be relatively insensitive to the thickness of graphitic interface layer and was enhanced somewhat by the addition of oxidation inhibitors. Electron microscopy and oxidation studies indicated that the life of the Nic/SiC composites was governed by the oxidation of the graphitic interfaces and the on of glass(es) in composites due to the oxidation of the fiber and matrix, inhibitor phases.

Lin, Hua-Tay; Becher, P.F.

1996-02-01T23:59:59.000Z

320

Source fabrication and lifetime for Li{sup +} ion beams extracted from alumino-silicate sources  

SciTech Connect (OSTI)

A space-charge-limited beam with current densities (J) exceeding 1 mA/cm{sup 2} have been measured from lithium alumino-silicate ion sources at a temperature of {approx}1275 deg. C. At higher extraction voltages, the source appears to become emission limited with J{>=} 1.5 mA/cm{sup 2}, and J increases weakly with the applied voltage. A 6.35 mm diameter source with an alumino-silicate coating, {<=}0.25 mm thick, has a measured lifetime of {approx}40 h at {approx}1275 deg. C, when pulsed at 0.05 Hz and with pulse length of {approx}6 {mu}s each. At this rate, the source lifetime was independent of the actual beam charge extracted due to the loss of neutral atoms at high temperature. The source lifetime increases with the amount of alumino-silicate coated on the emitting surface, and may also be further extended if the temperature is reduced between pulses.

Roy, Prabir K.; Greenway, Wayne G.; Kwan, Joe W. [Lawrence Berkeley National Laboratory (LBNL), One Cyclotron Road, Berkeley, California 94720 (United States)

2012-04-15T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
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to obtain the most current and comprehensive results.


321

Source fabrication and lifetime for Li{sup +} ion beams extracted from alumino-silicate sources  

SciTech Connect (OSTI)

A space-charge-limited beam with current densities (J) exceeding 1 mA/cm{sup 2} have been measured from lithium alumino-silicate ion sources at a temperature of ?1275{degrees}C. At higher extraction voltages, the source appears to become emission limited with J ? 1.5 mA/cm{sup 2}, and J increases weakly with the applied voltage. A source with an alumino-silicate coating 6.35 mm in diameter and ?0.25 mm thick, has a lifetime of ?40 hours at ?1275{degrees}C, when pulsed at 0.05 Hz and with pulse length of ?6 ?s each. At this rate, the source lifetime was independent of the actual beam charge extracted due to the loss of neutral atoms at high temperature. Furthermore, the source lifetime increases with the amount of alumino-silicate coated on the emitting surface, and may also be extended if the temperature is reduced between pulses.

Greenway, W. G.; Kwan, J. W.

2012-02-10T23:59:59.000Z

322

Source fabrication and lifetime for Li+ ion beams extracted from alumino-silicate sources  

SciTech Connect (OSTI)

A space-charge-limited beam with current densities (J) exceeding 1 mA/cm{sup 2} have been measured from lithium alumino-silicate ion sources at a temperature of #24;~1275#14;{degrees} C. At higher extraction voltages, the source appears to become emission limited with J #21;{>=} 1.5 mA/cm{sup 2}, and J increases weakly with the applied voltage. A 6.35 mm diameter source with an alumino-silicate coating, {<=}#20;0.25 mm thick, has a measured lifetime of ~#24;40 hours at ~#24;1275#14;{degrees} C, when pulsed at 0.05 Hz and with pulse length of #24;~6 μs each. At this rate, the source lifetime was independent of the actual beam charge extracted due to the loss of neutral atoms at high temperature. The source lifetime increases with the amount of alumino-silicate coated on the emitting surface, and may also be further extended if the temperature is reduced between pulses.

Roy, Prabir K.; Greenway, Wayne G.; Kwan, Joe W

2012-03-05T23:59:59.000Z

323

Rangeland Risk Management for Texans: Types of Risk  

E-Print Network [OSTI]

Types of risk associated with range ecosystems include climatic, biological, financial and political risks. These risks are explained so that managers can know how to handle them....

White, Larry D.; Hanselka, C. Wayne

2000-11-01T23:59:59.000Z

324

Risk Dynamics?An Analysis for the Risk of Change  

E-Print Network [OSTI]

Bookstaber, R. (1999). "Risk Management in ComplexG. E. (2004). "How Useful Is Quantitative Risk Assessment?"Risk Analysis, Aubrey, A. (2010). "Preventing Diabetes:

Huang, Tailin

2010-01-01T23:59:59.000Z

325

Studies on the Use of Liquid Surface Passivation for Lifetime Measurements on Good-Quality Silicon Wafers  

SciTech Connect (OSTI)

We evaluated several liquid passivants, viz. solutions of iodine ethanol (IE), quinhydrone methanol (QHM), and potassium cyanide (KCN), for measuring minority-carrier lifetime. Lifetime was measured by the WCT-100 (Sinton Instruments) and WT-2000 (Semilab). Our results show that both IE and QHM passivation are reliable mechanisms. We also find that the KCN solution is moderately passivating on oxidized surfaces, but is only minimally effective on bare Si surfaces. This paper presents details of our studies. In particular, the effect of illumination on IE-passivated surfaces and possible reasons for variations in lifetime measurement are discussed.

Devayajanam, S.; Rupnowski, P.; Shet, S.; Sopori, B. L.; Ravindra, N. M.; Caskey, D.; Chang, J.; Covington, J.

2011-01-01T23:59:59.000Z

326

Learning and risk aversion  

E-Print Network [OSTI]

This dissertation contains three essays on learning and risk aversion. In the first essay we consider how learning may lead to risk averse behavior. A learning rule is said to be risk averse if it is expected to add more probability to an action...

Oyarzun, Carlos

2009-06-02T23:59:59.000Z

327

Paul Workman Cancer Research UK Cancer Therapeutics Unit  

E-Print Network [OSTI]

Paul Workman Cancer Research UK Cancer Therapeutics Unit Institute of Cancer Research/Royal Marsden Hospital Sutton, Surrey SM2 5NG UK ian.collins@icr.ac.uk Drugging the cancer genome: The challenges therapeutic agents Personalised diagnosis and treatment Exploiting cancer biology and the cancer genome

328

Subjective Risk, Confidence, and Ambiguity  

E-Print Network [OSTI]

Paper 1103) Subjective Risk, Confidence, and Ambiguityby author(s). Subjective Risk, Con?dence, and Ambiguity ?567. Ellsberg, D. (1961), ‘Risk, ambiguity and the savage

Traeger, Christian P.

2011-01-01T23:59:59.000Z

329

Essays in time and risk  

E-Print Network [OSTI]

4.4.1 Risk Attitudes . . . . . . . . . . . . . . . . .3.3.1 Additional Risk Preference Measures . . . . . . . .An Endowment Effect for Risk: Experimental Tests of

Sprenger, Charles

2011-01-01T23:59:59.000Z

330

Second Solid Cancers After Radiation Therapy: A Systematic Review of the Epidemiologic Studies of the Radiation Dose-Response Relationship  

SciTech Connect (OSTI)

Rapid innovations in radiation therapy techniques have resulted in an urgent need for risk projection models for second cancer risks from high-dose radiation exposure, because direct observation of the late effects of newer treatments will require patient follow-up for a decade or more. However, the patterns of cancer risk after fractionated high-dose radiation are much less well understood than those after lower-dose exposures (0.1-5 Gy). In particular, there is uncertainty about the shape of the dose-response curve at high doses and about the magnitude of the second cancer risk per unit dose. We reviewed the available evidence from epidemiologic studies of second solid cancers in organs that received high-dose exposure (>5 Gy) from radiation therapy where dose-response curves were estimated from individual organ-specific doses. We included 28 eligible studies with 3434 second cancer patients across 11 second solid cancers. Overall, there was little evidence that the dose-response curve was nonlinear in the direction of a downturn in risk, even at organ doses of ?60 Gy. Thyroid cancer was the only exception, with evidence of a downturn after 20 Gy. Generally the excess relative risk per Gray, taking account of age and sex, was 5 to 10 times lower than the risk from acute exposures of <2 Gy among the Japanese atomic bomb survivors. However, the magnitude of the reduction in risk varied according to the second cancer. The results of our review provide insights into radiation carcinogenesis from fractionated high-dose exposures and are generally consistent with current theoretical models. The results can be used to refine the development of second solid cancer risk projection models for novel radiation therapy techniques.

Berrington de Gonzalez, Amy, E-mail: berringtona@mail.nih.gov [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Gilbert, Ethel; Curtis, Rochelle; Inskip, Peter; Kleinerman, Ruth; Morton, Lindsay; Rajaraman, Preetha; Little, Mark P. [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)

2013-06-01T23:59:59.000Z

331

Pulse length and terminal-level lifetime dependence of energy extraction for neodymium-doped phosphate amplifier glass  

SciTech Connect (OSTI)

On the basis of detailed numerical calculations, the authors have formulated an empirical expression for the saturation fluence in neodymium-doped phosphate amplifier glass that explicitly depends upon the ratio of the pulse width to the terminal-level lifetime. The empirical expression, when substituted within the Frantz-Nodvik solution for energy extraction, can be used to determine the impact of the lower level lifetime on the energy extracted from Nd:phosphate glass amplifiers. They used their empirical solution to model experimental gain-saturation data and determine the terminal-level lifetime. They compared this value with two independent experiments and found that all three experiments yielded similar results. The terminal-level lifetime of LG-750 at room temperature is found to be 253 ps {+-} 50 ps.

Bibeau, C.; Trenholme, J.B.; Payne, S.A. [Lawrence Livermore National Lab., CA (United States)] [Lawrence Livermore National Lab., CA (United States)

1996-08-01T23:59:59.000Z

332

Lifetime Tests on a High Ohms/Square Metalized High Crystalline Polypropylene Film Capacitor with Application to a Marx Modulator  

SciTech Connect (OSTI)

This paper presents accelerated lifetime tests on a polypropylene film capacitor. Experimental parameters (20% droop, 5 Hz repetition rate) simulate anticipated operating conditions encountered in the SLAC P2 Marx. Elevated film electric field stress is utilized as the acceleration parameter. Results indicate that, for the particular film of interest, a film stress of {approx}290 V/{mu}m corresponds to a 10{sup 5} hour lifetime. In addition, the voltage scaling exponent for this film is 13.1.

Kemp, Mark A.; Burkhart, Craig; Tang, Tao; /SLAC; ,

2010-06-07T23:59:59.000Z

333

Lifetime Response of a Hi-Nicalon Fiber-Reinforced Melt-Infiltrated SiC Matrix Composites  

SciTech Connect (OSTI)

Lifetime studies in four-point flexure were performed on a Hi-NicalonTM fiber-reinforced SiC matrix composite over a temperature range of 700 degrees to 1150 degrees C in air. The composite consisted of ~40 vol. % Hi-NicalonTM fiber (8-harness weave) with a 0.5 Mu-m BN fiber coating and a melt-infiltration SiC matrix wand was tested with as-machined surfaces. Lifetime results indicated that the composite exhibited a stress-dependent lifetime at stress levels above an apparent fatigue limit, similar to the trend observed in CG-NicalonTM fiber reinforced CVI SiC matrix composites. At less than or equal to 950 degrees C, the lifetimes of Hi-Nicalon/MI SiC composites decreased with increasing applied stress level and test temperature. However, the lifetimes were extended as test temperature increased from 950 degees to 1150 degrees C as a result of surface crack sealing due to glass formation by the oxidation of Mi SiC matrix. The lifetime governing processes were, in general, attributed to the progressive oxidation of BN fiber coating and formation of glassy phase, which formed a strong bond between fiber and matrix, resulting in embrittlement of the composite with time.

Becher, P.F.; Lin, H.T.; Singh, M.

1999-04-25T23:59:59.000Z

334

From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory  

SciTech Connect (OSTI)

In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

Martineau, Rebecca M [Los Alamos National Laboratory

2012-07-26T23:59:59.000Z

335

Cancer Research Beckman Institute  

E-Print Network [OSTI]

Cancer Research Beckman Institute FOR ADVANCED SCIENCE AND TECHNOLOGY #12;T The medical and scientific worlds have known for many years that in order to truly understand and treat cancer, the fight has and cancerous tumors have to first be visualized at the smallest scales possible, and then treated in the most

Illinois at Urbana-Champaign, University of

336

Intervention strategies for energy efficient municipal buildings: Influencing energy decisions throughout buildings` lifetimes  

SciTech Connect (OSTI)

The current energy-related decisionmaking processes that take place during the lifetimes of municipal buildings in San Francisco do not reflect our ideal picture of energy efficiency as a part of staff awareness and standard practice. Two key problems that undermine the success of energy efficiency programs are lost opportunities and incomplete actions. These problems can be caused by technology-related issues, but often the causes are institutional barriers (organizational or procedural {open_quotes}people problems{close_quotes}). Energy efficient decisions are not being made because of a lack of awareness or policy mandate, or because financial resources are not available to decisionmakers. The Bureau of Energy Conservation (BEC) is working to solve such problems in the City & County of San Francisco through the Intervention Strategies project. In the first phase of the project, using the framework of the building lifetime, we learned how energy efficiency in San Francisco municipal buildings can be influenced through delivering services to support decisionmakers; at key points in the process of funding, designing, constructing and maintaining them. The second phase of the project involved choosing and implementing five pilot projects. Through staff interviews, we learned how decisions that impact energy use are made at various levels. We compiled information about city staff and their needs, and resources available to meet those needs. We then designed actions to deliver appropriate services to staff at these key access points. BEC implemented five pilot projects corresponding to various stages in the building`s lifetime. These were: Bond Guidelines, Energy Efficient Design Practices, Commissioning, Motor Efficiency, and Facilities Condition Monitoring Program.

NONE

1993-12-31T23:59:59.000Z

337

Experimental limits on the proton life-time from the neutrino experiments with heavy water  

E-Print Network [OSTI]

Experimental data on the number of neutrons born in the heavy water targets of the large neutrino detectors are used to set the limit on the proton life-time independently on decay mode through the reaction d -> n+?. The best up-to-date limit tau_p > 4 10^23 yr with 95% C.L. is derived from the measurements with D_2O target (mass 267 kg) installed near the Bugey reactor. This value can be improved by six orders of magnitude with future data accumulated with the SNO detector containing 1000 t of D_2O.

V. I. Tretyak; Yu. G. Zdesenko

2001-04-11T23:59:59.000Z

338

Development of time projection chamber for precise neutron lifetime measurement using pulsed cold neutron beams  

E-Print Network [OSTI]

A new time projection chamber (TPC) was developed for neutron lifetime measurement using a pulsed cold neutron spallation source at the Japan Proton Accelerator Research Complex (J-PARC). Managing considerable background events from natural sources and the beam radioactivity is a challenging aspect of this measurement. To overcome this problem, the developed TPC has unprecedented features such as the use of polyether-ether-ketone plates in the support structure and internal surfaces covered with $^6$Li-enriched tiles to absorb outlier neutrons. In this paper, the design and performance of the new TPC are reported in detail.

Arimoto, Y; Igarashi, Y; Iwashita, Y; Ino, T; Katayama, R; Kitahara, R; Kitaguchi, M; Matsumura, H; Mishima, K; Oide, H; Otono, H; Sakakibara, R; Shima, T; Shimizu, H M; Sugino, T; Sumi, N; Sumino, H; Taketani, K; Tanaka, G; Tanaka, M; Tauchi, K; Toyoda, A; Yamada, T; Yamashita, S; Yokoyama, H; Yoshioka, T

2015-01-01T23:59:59.000Z

339

Project Risk Management:.  

E-Print Network [OSTI]

?? The recent increase in international projects has resulted in higher risk along with difficulties in control and coordination. Effective project management can therefore be… (more)

Koelmeyer, Chris

2013-01-01T23:59:59.000Z

340

Risk-Informed Decisions  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Laboratory's Risk-Informed Decisions division study the interaction between human and machines to determine how that relationship can be improved in order to enhance performance...

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Political Risk in Finland.  

E-Print Network [OSTI]

?? Thesis political risk in Finland will explain the real nature of the financial crisis in Finland in the beginning of 1990’s. Before 1990’s Finland… (more)

Davidsson, Jukka

2007-01-01T23:59:59.000Z

342

Work at FNAL to achieve long electron drift lifetime in liquid argon  

SciTech Connect (OSTI)

This note records some of the work done between July 2005 and July 2006 to achieve long (many milliseconds) electron drift lifetimes in liquid argon at Fermilab. The work is part of a process to develop some experience at Fermilab with the technology required to construct a large liquid argon TPC. This technology has been largely developed by the ICARUS collaboration in Europe and this process can be seen as technology transfer. The capability to produce liquid argon in which electrons have drift lifetimes of several milliseconds is crucial to a successful device. Liquid argon calorimeters have been successfully operated at Fermilab; their electro-negative contaminants are at the level of 10{sup -7} while the TPC we are considering requires a contamination level at the level of 10{sup -11}, tens of parts per trillion (ppt). As well as demonstrating the ability to produce liquid argon at this level of purity, the work is part of a program to test the effect on the electron drift time of candidate materials for the construction of a TPC in liquid argon.

Finley, D.; Jaskierny, W.; Kendziora, C.; Krider, J.; Pordes, S.; Rapidis, P.A.; Tope, T.; /Fermilab

2006-10-01T23:59:59.000Z

343

A Modification of the Inner and Outer Core for Reactor Pressure Vessel Lifetime Extension  

SciTech Connect (OSTI)

The feasibility of nuclear power plant lifetime extension was examined by reducing the fast neutron fluence at the reactor pressure vessel (RPV) and relieving irradiation embrittlement of materials, and thus ensuring enough structural integrity beyond the design lifetime. Two fluence reduction options, peripheral assembly replacement and additional shield installation in the outer core structures, were applied to the Kori Unit-1 reactor, and the fluence reduction effect was carefully analyzed. For an accurate estimate of the neutron fluence at the RPV and a reasonable description of the modified peripheral assemblies, a full-scope explicit modeling of a Monte Carlo simulation was employed in all calculations throughout this study. The Kori Unit-1 cycle-16 core was modeled on a three-dimensional representation by using the MCNP4B code, and the fluence distribution was estimated at the inner wall beltline around the circumferential weld of the RPV. On the basis of fracture toughness requirements of the RPV, the two modified cases were predicted to have an additional life of 7 to 10 effective full-power years. Throughout the core nuclear characteristics analyses, it was confirmed that the critical peaking factors for safe reactor operation were satisfied with the design limits.

Seo, Bo Kyun [Hanyang University (Korea, Republic of); Kim, Jong Kyung [Hanyang University (Korea, Republic of); Shin, Chang Ho [Hanyang University (Korea, Republic of); Kwon, Tae Je [Nuclear Fuel Company (Korea, Republic of)

2001-03-15T23:59:59.000Z

344

Constraining cloud lifetime effects of aerosols using A-Train satellite observations  

SciTech Connect (OSTI)

Aerosol indirect effects have remained the largest uncertainty in estimates of the radiative forcing of past and future climate change. Observational constraints on cloud lifetime effects are particularly challenging since it is difficult to separate aerosol effects from meteorological influences. Here we use three global climate models, including a multi-scale aerosol-climate model PNNL-MMF, to show that the dependence of the probability of precipitation on aerosol loading, termed the precipitation frequency susceptibility (S{sub pop}), is a good measure of the liquid water path response to aerosol perturbation ({lambda}), as both Spop and {lambda} strongly depend on the magnitude of autoconversion, a model representation of precipitation formation via collisions among cloud droplets. This provides a method to use satellite observations to constrain cloud lifetime effects in global climate models. S{sub pop} in marine clouds estimated from CloudSat, MODIS and AMSR-E observations is substantially lower than that from global climate models and suggests a liquid water path increase of less than 5% from doubled cloud condensation nuclei concentrations. This implies a substantially smaller impact on shortwave cloud radiative forcing (SWCF) over ocean due to aerosol indirect effects than simulated by current global climate models (a reduction by one-third for one of the conventional aerosol-climate models). Further work is needed to quantify the uncertainties in satellite-derived estimates of S{sub pop} and to examine S{sub pop} in high-resolution models.

Wang, Minghuai; Ghan, Steven J.; Liu, Xiaohong; Ecuyer, Tristan L.; Zhang, Kai; Morrison, H.; Ovchinnikov, Mikhail; Easter, Richard C.; Marchand, Roger; Chand, Duli; Qian, Yun; Penner, Joyce E.

2012-08-15T23:59:59.000Z

345

Spontaneous fission modes and lifetimes of super-heavy elements in the nuclear density functional theory  

E-Print Network [OSTI]

Lifetimes of super-heavy (SH) nuclei are primarily governed by alpha decay and spontaneous fission (SF). Here we study the competing decay modes of even-even SH isotopes with 108 density functional theory framework capable of describing the competition between nuclear attraction and electrostatic repulsion. The collective mass tensor of the fissioning superfluid nucleus is computed by means of the cranking approximation to the adiabatic time-dependent Hartree-Fock-Bogoliubov approach. Along the path to fission, our calculations allow for the simultaneous breaking of axial and space inversion symmetries; this may result in lowering SF lifetimes by more than seven orders of magnitude in some cases. We predict two competing SF modes: reflection-symmetric and reflection-asymmetric.The shortest-lived SH isotopes decay by SF; they are expected to lie in a narrow corridor formed by $^{280}$Hs, $^{284}$Fl, and $^{284}_{118}$Uuo that separates the regions of SH nuclei synthesized in "cold fusion" and "hot fusion" reactions. The region of long-lived SH nuclei is expected to be centered on $^{294}$Ds with a total half-life of ?1.5 days.

A. Staszczak; A. Baran; W. Nazarewicz

2012-08-06T23:59:59.000Z

346

Lifetime measurement of metastable fluorine atoms using electron cyclotron resonance plasma source  

SciTech Connect (OSTI)

The authors have measured the lifetime of metastable state (3s {sup 4}P{sub 5/2}) of F atoms by resonant laser-induced fluorescence method. For this experiment, a special 2.45 GHz electron cyclotron resonance (ECR) plasma source, which is highly efficient in F radical generation and free from magnetic field leakage in front of the beam-emitting orifice, has been developed. Using the ECR plasma gun, the authors observed a precision fluorescence spectrum related to 3p {sup 4}D{sub 7/2}{sup 0}(F=4){yields}3s {sup 4}P{sub 5/2}(F=3) transition of F radicals, which made it possible to experimentally determine the longitudinal velocity distribution and the angular spread of the F radical beam. Based on these measured beam characteristics, the authors extracted a true decay curve of fluorescence intensity as a function of distance from the source and determined the lifetime of F metastable state (3s {sup 4}P{sub 5/2}) as 7.3{+-}0.5 {mu}s.

Shimizu, Masao; Ohmi, Hiromasa; Kakiuchi, Hiroaki; Yasutake, Kiyoshi [Yasu Semiconductor Corporation, 686-1 Ichimiyake, Yasu-cho, Yasu-gun, Shiga 520-2632 (Japan); Department of Precision Science and Technology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)

2006-11-15T23:59:59.000Z

347

Measurement of the B+- lifetime and top quark identification using secondary vertex b-tagging  

SciTech Connect (OSTI)

This dissertation presents a preliminary measurement of the B{sup {+-}} lifetime through the full reconstruction of its decay chain, and the identification of top quark production in the electron plus jets channel using the displaced vertex b-tagging method. Its main contribution is the development, implementation and optimization of the Kalman filter algorithm for vertex reconstruction, and of the displaced vertex technique for tagging jets arising from b quark fragmentation, both of which have now become part of the standard D0 reconstruction package. These two algorithms fully exploit the new state-of-the-art tracking detectors, recently installed as part of the Run 2 D0 upgrade project. The analysis is based on data collected during Run 2a at the Fermilab Tevatron p{bar p} Hadron Collider up to April 2003, corresponding to an integrated luminosity of 60 pb{sup -1}. The measured B meson lifetime of {tau} = 1.57 {+-} 0.18 ps is in agreement with the current world average, with a competitive level of precision expected when the full data sample becomes available.

Schwartzman, Ariel G

2004-02-01T23:59:59.000Z

348

Finance and Risk & ENGINEERING  

E-Print Network [OSTI]

Finance and Risk & ENGINEERING Charles S. Tapiero Department Head and Morton and Angela Topfer · Corporate Finance and Financial Markets · Computational Finance · Risk Finance · Technology and Algorithmic Finance A Collective Leadership Students participation #12;RESEARCH STRENGTHS · Black Swans and Fragility

Aronov, Boris

349

Cumulative exposure to arsenic and its relationship to respiratory cancer among copper-smelter employees  

SciTech Connect (OSTI)

To explore the role of arsenic as a human carcinogen, the respiratory cancer-mortality experience (1938 to 1977) of 8045 white-male smelter employees in Montana was examined relative to cumulative exposure to arsenic trioxide and was compared with that of the white male population of the same region. Exposure to arsenic was estimated for various work areas from industrial-hygiene reports of average concentrations present in the smelter. Respiratory cancer mortality was analyzed further by time period of first employment and maximum lifetime exposure to arsenic trioxide. When exposure was estimated with arithmetic means of measured concentrations among men first employed prior to 1925, respiratory cancer mortality increased linearly with increasing cumulative exposure group, ranging from two to nine times expected; among those first employed in the period 1925 to 1947 it also increased linearly with increasing cumulative exposure group.

Lee-Feldstein, A.

1986-01-01T23:59:59.000Z

350

Cumulative exposure to arsenic and its relationship to respiratory cancer among copper smelter employees  

SciTech Connect (OSTI)

To explore the role of arsenic as a human carcinogen, the respiratory cancer mortality experience (1938 to 1977) of 8,045 while male smelter employees in Montana was examined relative to cumulative exposure to arsenic trioxide and was compared with that of the white male population of the same region. Exposure to arsenic was estimated for various work areas from industrial hygiene reports of average concentrations present in the smelter. Respiratory cancer mortality was analyzed further by time period of first employment and maximum lifetime exposure to arsenic trioxide. When exposure was estimated with arithmetic means of measured concentrations among men first employed prior to 1925, respiratory cancer mortality increased linearly with increasing cumulative exposure group, ranging from two to nine times expected; among those first employed in the period 1925 to 1947 it also increased linearly with increasing cumulative exposure group.

Lee-Feldstein, A.

1986-04-01T23:59:59.000Z

351

Nested methylation-specific polymerase chain reaction cancer detection method  

DOE Patents [OSTI]

A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

2007-05-08T23:59:59.000Z

352

Lung cancer epidemiology in New Mexico uranium miners  

SciTech Connect (OSTI)

This investigation assesses the health effects of radon progeny exposure in New Mexico uranium miners. Cumulative exposures sustained by most New Mexico miners are well below those received earlier in the Colorado Plateau. This project utilizes the research opportunity offered by New Mexico miners to address unresolved issues related to radon progeny exposure: (1) the lung cancer risk of lower levels of exposure, (2) interaction between radon progeny exposure and cigarette smoking in the causation of lung cancer, (3) the relationship between lung cancer histologic type and radon progeny exposure, and (4) possible effects of radon progeny exposure other than lung cancer. A cohort study of 3800 men with at least one year of underground uranium mining experience in New Mexico is in progress. Results are discussed.

Samet, J.M.

1991-11-01T23:59:59.000Z

353

Analysis of Xq27-28 Linkage in the International Consortium for Prostate Cancer Genetics (ICPCG) Families  

E-Print Network [OSTI]

. Ardern-Jones, D. Dearnaley, The UKGPCS Collaborators, British Association of Urological Surgeons' Section of Oncology, R. Eeles + UK, Cambridge: Chris Evans, M. Dawn Teare, Doug Easton + (Cancer Research UK Genetic Epidemiology Unit, Strangeways Research... risk and progression. Carcinogenesis 2010, 31(9):1597–1603. 8. Fesinmeyer MD, Kwon EM, Fu R, Ostrander EA, Stanford JL: Genetic variation in RNASEL and risk for prostate cancer in a population-based case–control study. Prostate 2011, 71...

Bailey-Wilson, Joan E; Childs, Erica J; Cropp, Cheryl D; Schaid, Daniel J; Xu, Jianfeng; Camp, Nicola J; Cannon-Albright, Lisa A; Farnham, James M; George, Asha; Powell, Isaac; Carpten, John D; Giles, Graham G; Hopper, John L; Severi, Gianluca; English, Dallas R; Foulkes, William D; Mæhle, Lovise; Møller, Pål; Eeles, Rosalind; Easton, Douglas; Guy, Michelle; Edwards, Steve; Badzioch, Michael D; Whittemore, Alice S; Oakley-Girvan, Ingrid; Hsieh, Chih-Lin; Dimitrov, Latchezar; Stanford, Janet L; Karyadi, Danielle M; Deutsch, Kerry; McIntosh, Laura; Ostrander, Elaine A; Wiley, Kathleen E; Isaacs, Sarah D; Walsh, Patrick C; Thibodeau, Stephen N; McDonnell, Shannon K; Hebbring, Scott; Lange, Ethan M; Cooney, Kathleen A; Tammela, Teuvo LJ; Schleutker, Johanna; Maier, Christiane; Bochum, Sylvia; Hoegel, Josef; Grönberg, Henrik; Wiklund, Fredrik; Emanuelsson, Monica; Cancel-Tassin, Geraldine; Valeri, Antoine; Cussenot, Olivier; Isaacs, William B; International Consortium for Prostate Cancer Genetics

2012-06-19T23:59:59.000Z

354

Cancer Due to Prolonged Inflammation  

E-Print Network [OSTI]

Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

Lingampalli, Nithya

2013-01-01T23:59:59.000Z

355

Bismuth 213 Cancer Treatment  

ScienceCinema (OSTI)

See how INL scientists are increasing supplies of radioactive medical isotopes to treat cancer. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

None

2013-05-28T23:59:59.000Z

356

An overview of the US Department of Energy Plant Lifetime Improvement Program  

SciTech Connect (OSTI)

This paper provides a brief summary of the U.S. Department of Energy`s (USDOE`s) cooperative effort with the nuclear industry to develop technology to manage the effects of material degradation in systems, structures and components (SSCs) that impact plant safety or can significantly improve plant performance/economics and to establish and demonstrate the license renewal process. Also included are efforts to reduce decontamination/decommission costs, and reduce the uncertainty in long-term service-life decision making. During 1995, the Plant Lifetime Improvement (PLIM) Program was renamed the Commercial Operating Light Water Reactor (COLWR) Program activities are focused on sustaining the LWR option for domestic electricity generation by supporting operation of existing LWRs as long as they are safe, efficient, and economical. The status of the key projects is discussed in this paper.

Moonka, A.K. [Los Alamos National Lab., NM (United States); Harrison, D.L. [USDOE, Washington, DC (United States)

1995-08-01T23:59:59.000Z

357

Theory and models of material erosion and lifetime during plasma instabilities in a tokamak environment.  

SciTech Connect (OSTI)

Surface and structural damage to plasma-facing components (PFCs) due to the frequent loss of plasma confinement remains a serious problem for the tokamak reactor concept. The deposited plasma energy causes significant surface erosion, possible structural failure, and frequent plasma contamination. Surface damage consists of vaporization, spallation, and liquid splatter of metallic materials. Structural damage includes large temperature increases in structural materials and at the interfaces between surface coatings and structural members. To evaluate the lifetimes of plasma-facing materials and nearby components and to predict the various forms of damage that they experience, comprehensive models (contained in the HEIGHTS computer simulation package) are developed, integrated self-consistently, and enhanced. Splashing mechanisms such as bubble boiling and various liquid magnetohydrodynamic instabilities and brittle destruction mechanisms of nonmelting materials are being examined. The design requirements and implications of plasma-facing and nearby components are discussed, along with recommendations to mitigate and reduce the effects of plasma instabilities on reactor components.

Hassanein, A.; Konkashbaev, I.

1999-11-08T23:59:59.000Z

358

EFFECTIVE LIFETIME ESTIMATE OF CRIMPED POWERLINE SPLICE CONNECTOR OPERATED AT HIGH TEMPERATURE  

SciTech Connect (OSTI)

This paper addresses the thermal-mechanical properties and performance characteristics of full tension splice connectors under high temperature operation, in particular those used in overhead transmission and distribution lines. Due to the increase in power demand existing overhead power transmission lines often need to operate at temperatures higher than those originally considered for their design. This has led to the accelerated aging and degradation of splice connectors. The compressive residual stresses induced by the crimping process within the splice connector provide the clamping forces to secure the conductor and therefore, the determination of the state of compressive residual stresses in splice connectors is a necessary requirement to provide an accurate estimate of their service lifetime. This paper presents a protocol for integrating analytical and experimental approaches to evaluate the integrity of a full tension single-stage splice connector assembly.

Wang, Jy-An John [ORNL] [ORNL; Lara-Curzio, Edgar [ORNL] [ORNL; King Jr, Thomas J [ORNL] [ORNL; An, Ke [ORNL] [ORNL; Hubbard, Camden R [ORNL] [ORNL

2008-01-01T23:59:59.000Z

359

Lifetime Measurement of the 2{sup +}{sub 1} state in {sup 20}C  

SciTech Connect (OSTI)

Establishing how and when large N/Z values require modified or new theoretical tools is a major quest in nuclear physics. Here we report the first measurement of the lifetime of the 2{sup +}{sub 1} state in the near-dripline nucleus {sup 20}C. The deduced value of {tau}{sub #28;2{sup +}{sub 1}} = 9.8 ± 2.8(stat){sup +0.5}{sub ?1.1}(syst) ps gives a reduced transition probability of B(E2;2{sup +}{sub 1}{yields}0{sup +}{sub g.s.}) = 7.5{sup +3.0}{sub ?1.7}(stat){sup +1.0}{sub ?0.4}(syst) e{sup 2}fm{sup 4} in good agreement with a shell model calculation using isospin-dependent effective charges.

Petri, Marina-Kalliopi; Fallon, Paul; Macchiavelli, Augusto; Paschalis, Stephanos; Starosta, Krzysztof; Baugher, Travis; Bazin, Daniel; Cartegni, Lucia; Clark, Roderick; Crawford, Heather; Cromaz, Mario; Dewald, Alfred; Gade, Alexandra; Grinyer, Geoff; Gros, Sebastian; Hackstein, Matthias; Jeppesen, Hendrick; Lee, I-Yang; McDaniel, Sean; Miller, Doug; Rajabali, Mustafa; Ratkiewicz, Andrew; Rother, Wolfram; Voss, Phillip; Walsh, Kathleen Ann; Weisshaar, Dirk; Wiedeking, Mathis; Brown, Boyd Alex

2011-06-28T23:59:59.000Z

360

Study of behavior and determination of customer lifetime value(CLV) using Markov chain model  

SciTech Connect (OSTI)

Customer Lifetime Value or CLV is a restriction on interactive marketing to help a company in arranging financial for the marketing of new customer acquisition and customer retention. Additionally CLV can be able to segment customers for financial arrangements. Stochastic models for the fairly new CLV used a Markov chain. In this model customer retention probability and new customer acquisition probability play an important role. This model is originally introduced by Pfeifer and Carraway in 2000 [1]. They introduced several CLV models, one of them only involves customer and former customer. In this paper we expand the model by adding the assumption of the transition from former customer to customer. In the proposed model, the CLV value is higher than the CLV value obtained by Pfeifer and Caraway model. But our model still requires a longer convergence time.

Permana, Dony, E-mail: donypermana@students.itb.ac.id [Statistics Research Division, Faculty of Mathematics and Natural Science, Bandung Institute of Technology, Indonesia and Statistics Study Program, Faculty of Mathematics and Natural Sciences, Padang State University (Indonesia); Indratno, Sapto Wahyu; Pasaribu, Udjianna S. [Statistics Research Division, Faculty of Mathematics and Natural Science, Bandung Institute of Technology (Indonesia)

2014-03-24T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

PREDICTION OF DISSOLVER LIFETIMES THROUGH NON-DESTRUCTIVE EVALUATION AND LABORATORY TESTING  

SciTech Connect (OSTI)

Non-destructive evaluation was used as the primary method of monitoring the corrosion degradation of nuclear material dissolvers and assessing the remaining lifetimes. Materials were typically processed in nitric acid based (4-14M) solutions containing fluoride concentrations less than 0.2 M. The primary corrosion issue for the stainless steel dissolvers is the occurrence of localized corrosion near the tank bottom and the heat affected zones of the welds. Laboratory data for a range of operational conditions, including solution chemistry and temperature, was used to assess the impact of processing changes on the dissolver corrosion rate. Experimental and NDE-based general corrosion rates were found to be in reasonable agreement for standard dissolution chemistries consisting of nitric acid with fluorides and at temperatures less than 95 C. Greater differences were observed when chloride was present as an impurity and temperatures exceeded 100 C.

Mickalonis, J.; Woodsmall, T.; Hinz, W.; Edwards, T.

2011-10-03T23:59:59.000Z

362

Systems at Risk as Risk to the System  

E-Print Network [OSTI]

infrastructure protection (CIP) debate itself, but its twosystemic risk language. CIP practitioners are particularlyinteraction. Risk: Because CIP is primarily concerned with

Cavelty, Myriam Dunn

2011-01-01T23:59:59.000Z

363

An overview of the United States Department of Energy plant lifetime improvement program  

SciTech Connect (OSTI)

Today, 109 nuclear power plants provide over 20 percent of the electrical energy generated in the US. The operating license of the first of these plants will expire in the year 2000; one third of the operating licenses will expire by 2010 and the remaining plant licenses are scheduled to expire by 2033. The National Energy Strategy assumes that 70 percent of these plants will continue to operate beyond their current license expiration to assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth. In order to preserve this energy resource in the US three major tasks must be successfully completed: (1) establishment of the regulations, technical standards, and procedures for the preparation and review of a license renewal application; (2) development, verification, and validation of the various technical criteria and bases for needed monitoring, refurbishment, or replacement of plant equipment; and (3) demonstration of the regulatory process. Since 1985, the US Department of Energy (DOE) has been working with the nuclear industry and the US Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of nuclear power plants through the renewal of operating licenses. This paper focuses primarily on DOE`s Plant Lifetime Improvement (PLIM) Program efforts to develop the technical criteria and bases for effective aging management and lifetime improvement for continued operation of nuclear power plants. This paper describes current projects to resolve generic technical issues, including degradation of long-lived components, reactor pressure vessel (RPV) embrittlement management approaches, and analytical methodologies to characterize RPV integrity.

Rosinski, S.T.; Clauss, J.M. [Sandia National Labs., Albuquerque, NM (United States); Harrison, D.L. [USDOE, Washington, DC (United States)

1993-08-01T23:59:59.000Z

364

CONSTRAINTS ON THE LIFETIMES OF DISKS RESULTING FROM TIDALLY DESTROYED ROCKY PLANETARY BODIES  

SciTech Connect (OSTI)

Spitzer IRAC observations of 15 metal-polluted white dwarfs reveal infrared excesses in the spectral energy distributions of HE 0110-5630, GD 61, and HE 1349-2305. All three of these stars have helium-dominated atmospheres, and their infrared emissions are consistent with warm dust produced by the tidal destruction of (minor) planetary bodies. This study brings the number of metal-polluted, helium and hydrogen atmosphere white dwarfs surveyed with IRAC to 53 and 38, respectively. It also nearly doubles the number of metal-polluted helium-rich white dwarfs found to have closely orbiting dust by Spitzer. From the increased statistics for both atmospheric types with circumstellar dust, we derive a typical disk lifetime of log [t{sub disk}(yr)] = 5.6 {+-} 1.1 (ranging from 3 Multiplication-Sign 10{sup 4} to 5 Multiplication-Sign 10{sup 6} yr). This assumes a relatively constant rate of accretion over the timescale where dust persists, which is uncertain. We find that the fraction of highly metal-polluted helium-rich white dwarfs that have an infrared excess detected by Spitzer is only 23%, compared to 48% for metal-polluted hydrogen-rich white dwarfs, and we conclude from this difference that the typical lifetime of dusty disks is somewhat shorter than the diffusion timescales of helium-rich white dwarf. We also find evidence for higher time-averaged accretion rates onto helium-rich stars compared to the instantaneous accretion rates onto hydrogen-rich stars; this is an indication that our picture of evolved star-planetary system interactions is incomplete. We discuss some speculative scenarios that can explain the observations.

Girven, J.; Gaensicke, B. T.; Marsh, T. R. [Department of Physics, University of Warwick, Coventry CV4 7AL (United Kingdom); Brinkworth, C. S.; Hoard, D. W. [Spitzer Science Center, California Institute of Technology, Pasadena, CA 91125 (United States); Farihi, J. [Department of Physics and Astronomy, University of Leicester, Leicester LE1 7RH (United Kingdom); Koester, D., E-mail: j.m.girven@warwick.ac.uk [Institut fuer Theoretische Physik und Astrophysik, University of Kiel, 24098 Kiel (Germany)

2012-04-20T23:59:59.000Z

365

Progress on Establishing Guidelines for National Ignition Facility (NIF) Experiments to Extend Debris Shield Lifetime  

SciTech Connect (OSTI)

The survivability and performance of the debris shields on the National Ignition Facility (NIF) are a key factor for the successful conduct and affordable operation of the facility. The improvements required over Nova debris shields are described. Estimates of debris shield lifetimes in the presence of target emissions with 4 - 5 J/cm{sup 2} laser fluences (and higher) indicate lifetimes that may contribute unacceptably to operations costs for NIF. We are developing detailed guidance for target and experiment designers for NIF to assist in minimizing the damage to, and therefore the cost of, maintaining NIF debris shields. The guidance limits the target mass that is allowed to become particulate on the debris shields (300 mg). It also limits the amount of material that can become shrapnel for any given shot (10 mg). Finally, it restricts the introduction of non-volatile residue (NVR) that is a threat to the sol-gel coatings on the debris shields to ensure that the chamber loading at any time is less than 1 pg/cm{sup 2}. We review the experimentation on the Nova chamber that included measuring quantities of particulate on debris shields by element and capturing shrapnel pieces in aerogel samples mounted in the chamber. We also describe computations of x-ray emissions from a likely NIF target and the associated ablation expected from this x-ray exposure on supporting target hardware. We describe progress in assessing the benefits of a pre-shield and the possible impact on the guidance for target experiments on NIF. Plans for possible experimentation on Omega and other facilities to improve our understanding of target emissions and their impacts are discussed. Our discussion of planned future work provides a forum to invite possible collaboration with the IFE community.

Tobin, M; Eder, D; Braun, D; MacGowan, B

2000-07-26T23:59:59.000Z

366

Development of high performance refractory fibers with enhanced insulating properties and longer service lifetimes  

SciTech Connect (OSTI)

We have initiated a three phase investigation of the development of high performance refractory fibers with enhanced insulating properties and longer usable lifetimes. This report presents the results of the first phase of the study, performed from Aug. 1989 through Feb. 1991, which shows that significant energy saving are possible through the use of high temperature insulating fibers that better retain their efficient insulating properties during the service lifetime of the fibers. The remaining phases of this program include the pilot scale development and then full scale production feasibility development and evaluation of enhanced high temperature refractory insulting fibers. This first proof of principle phase of the program presents a summary of the current use patterns of refractory fibers, a laboratory evaluation of the high temperature performance characteristics of selected typical refractory fibers and an analysis of the potential energy savings through the use of enhanced refractory fibers. The current use patterns of refractory fibers span a wide range of industries and high temperature furnaces within those industries. The majority of high temperature fiber applications are in furnaces operating between 2000 and 26000{degrees}F. The fibers used in furnaces operating within this range provide attractive thermal resistance and low thermal storage at reasonable cost. A series of heat treatment studies performed for this phase of the program has shown that the refractory fibers, as initially manufactured, have attractive thermal conductivities for high temperature applications but the fibers go through rapid devitrification and subsequent crystal growth upon high temperature exposure. Development of improved fibers, maintaining the favorable characteristics of the existing as-manufactured fibers, could save between 1 and 4% of the energy consumed in high temperature furnaces using refractory fibers.

Martin, P.C.; DePoorter, G.L.; Munoz, D.R.

1991-02-01T23:59:59.000Z

367

Evaluation of Lifetime of High Efficiency Organic Photovoltaic Devices: Cooperative Research and Development Final Report, CRADA Number CRD-10-379  

SciTech Connect (OSTI)

As a part of this joint work, Solarmer and NREL will investigate the lifetime and stability of Organic Photovoltaic Devices based on Solarmer high efficiency active layer materials.

Olson, D.

2013-04-01T23:59:59.000Z

368

Risk in the Weapons Stockpile  

SciTech Connect (OSTI)

When it comes to the nuclear weapons stockpile, risk must be as low as possible. Design and care to keep the stockpile healthy involves all aspects of risk management. Design diversity is a method that helps to mitigate risk.

Noone, Bailey C [Los Alamos National Laboratory

2012-08-14T23:59:59.000Z

369

Measurement of the B meson Lifetimes with the Collider Detector at Fermilab  

SciTech Connect (OSTI)

The lifetimes of the B{sup -}, B{sup 0} and B{sub s}{sup 0} mesons are measured using partially reconstructed semileptonic decays. Following semileptonic decay processes and their charge conjugates are used for this analysis: B{sup -}/B{sup 0} {yields} {ell}{sup -}{nu}D{sup 0}X; B{sup -}/B{sup 0} {yields} {ell}{sup -}{nu}D*{sup +}X; B{sub s}{sup 0} {yields} {ell}{sup -}{nu}D{sub s}{sup +}x, where {ell}{sup -} denotes either a muon or electron. The data are collected during 2002-2004 by the 8 GeV single lepton triggers in CDF Run II at the Fermilab Tevatron Collider. Corresponding integrated luminosity is about 260 and 360 pb{sup -1} used for the B{sup -}/B{sup 0} and B{sub s}{sup 0} lifetime analyses, respectively. With the single lepton triggers, events which contain a muon or electron with a transverse momentum greater than 8 GeV/c are selected. For these lepton candidates, further lepton identification cuts are applied to improve purity of the B semileptonic decay signal. After the lepton selection, three types of charm mesons associated with the lepton candidates are reconstructed. Following exclusive decay modes are used for the charm meson reconstruction: D{sup 0} {yields} K{sup -}{pi}{sup +}; D*{sup +} {yields} D{sup 0}{pi}{sub s}{sup +}, followed by D{sup 0} {yields} K{sup -}{pi}{sup +}; D{sub s}{sup +} {yields} {phi}{pi}{sup +}, followed by {phi} {yields} K{sup +}K{sup -}. Here {pi}{sub s}{sup +} denotes a slow pion from D*{sup +} decay. Species of the reconstructed charm meson identify the parent B meson species. However in the B{sup -}/B{sup 0} semileptonic decays, both mesons decay into the identical lepton + D{sup 0} final state. To solve this mixture of the B components in the D{sup 0} sample, they adopt the following method: First among the inclusive D{sup 0} sample, they look for the D*{sup +} {yields} D{sup 0} {pi}{sub s}{sup +} signal. The inclusive D{sup 0} sample is then split into the two samples of D{sup 0} mesons which are from the D*{sup +} meson and not from D*{sup +}. They use the fact that D*{sup +} sample is dominated by the B{sup 0} component, and the D{sup 0} sample after excluding the D*{sup +} events is dominated by the B{sup -} component. Fraction of remaining mixture of B{sup -}/B{sup 0} components in each sample is estimated using a Monte Carlo simulation. From the lepton + charm meson pairs, they measure the B meson decay lengths to extract the lifetimes. Since the B meson momentum, necessary to calculate the B meson decay time, is not fully reconstructed in semileptonic decays, the missing momentum is corrected using a Monte Carlo simulation during lifetime fits. Also, contributions of various kinds of backgrounds are considered and subtracted. As a result of the fit, the B meson lifetimes are measured to be c{tau}(B{sup -}) = 495.6 {+-} 8.6 {sub -12.8}{sup +13.3} {micro}m; c{tau}(B{sup 0}) = 441.5 {+-} 10.9 {+-} 17.0 {micro}m; c{tau}(B{sub s}{sup 0}) = 414.0 {+-} 16.6 {sub -13.8}{sup +15.6} {micro}m or {tau}(B{sup 0}) = 1.653 {+-} 0.029 {sub -0.031}{sup +0.033} ps; {tau}(B{sup 0}) = 1.473 {+-} 0.036 {+-} 0.054 ps; {tau}(B{sub s}{sup 0}) = 1.381 {+-} 0.055 {sub -0.046}{sup +0.052} ps, and the lifetime ratios to be {tau}(B{sup 0})/{tau}(B{sup 0}) = 1.123 {+-} 0.040 {sub -0.039}{sup +0.041}; {tau}(B{sub s}{sup 0})/{tau}(B{sup 0}) = 0.938 {+-} 0.044 {sub -0.046}{sup +0.049} where the first uncertainty is statistical and the second is systematic.

Uozumi, Satoru; /Tsukuba U.

2006-01-01T23:59:59.000Z

370

RISK-INFORMED SAFETY MARGIN CHARACTERIZATION  

SciTech Connect (OSTI)

The concept of safety margins has served as a fundamental principle in the design and operation of commercial nuclear power plants (NPPs). Defined as the minimum distance between a system’s “loading” and its “capacity”, plant design and operation is predicated on ensuring an adequate safety margin for safety-significant parameters (e.g., fuel cladding temperature, containment pressure, etc.) is provided over the spectrum of anticipated plant operating, transient and accident conditions. To meet the anticipated challenges associated with extending the operational lifetimes of the current fleet of operating NPPs, the United States Department of Energy (USDOE), the Idaho National Laboratory (INL) and the Electric Power Research Institute (EPRI) have developed a collaboration to conduct coordinated research to identify and address the technological challenges and opportunities that likely would affect the safe and economic operation of the existing NPP fleet over the postulated long-term time horizons. In this paper we describe a framework for developing and implementing a Risk-Informed Safety Margin Characterization (RISMC) approach to evaluate and manage changes in plant safety margins over long time horizons.

Nam Dinh; Ronaldo Szilard

2009-07-01T23:59:59.000Z

371

ORISE: Crisis and Risk Communication  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Crisis and Risk Communication Crisis and Risk Communication Because a natural disaster, act of terrorism or other public emergency can happen without notice, having a planned,...

372

Livestock Risk Protection  

E-Print Network [OSTI]

Livestock risk protection (LRP) insurance policies protect producers from adverse price changes in the livestock market. This publication explains how LRP works, discusses the advantages and disadvantages of these polices, and gives examples...

Thompson, Bill; Bennett, Blake; Jones, Diana

2008-10-21T23:59:59.000Z

373

Risk Management Guide  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This Guide provides non-mandatory risk management approaches for implementing the requirements of DOE O 413.3B, Program and Project Management for the Acquisition of Capital Assets. Cancels DOE G 413.3-7.

2011-01-18T23:59:59.000Z

374

Receipt of Guideline-Concordant Treatment in Elderly Prostate Cancer Patients  

SciTech Connect (OSTI)

Purpose: To examine the proportion of elderly prostate cancer patients receiving guideline-concordant treatment, using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. Methods and Materials: A total of 29,001 men diagnosed in 2004-2007 with localized prostate cancer, aged 66 to 79 years, were included. We characterized the proportion of men who received treatment concordant with the National Comprehensive Cancer Network guidelines, stratified by risk group and age. Logistic regression was used to examine covariates associated with receipt of guideline-concordant management. Results: Guideline concordance was 79%-89% for patients with low- or intermediate-risk disease. Among high-risk patients, 66.6% of those aged 66-69 years received guideline-concordant management, compared with 51.9% of those aged 75-79 years. Discordance was mainly due to conservative management—no treatment or hormone therapy alone. Among the subgroup of patients aged ?76 years with no measured comorbidity, findings were similar. On multivariable analysis, older age (75-79 vs 66-69 years, odds ratio 0.51, 95% confidence interval 0.50-0.57) was associated with a lower likelihood of guideline concordance for high-risk prostate cancer, but comorbidity was not. Conclusions: There is undertreatment of elderly but healthy patients with high-risk prostate cancer, the most aggressive form of this disease.

Chen, Ronald C., E-mail: Ronald_chen@med.unc.edu [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Carpenter, William R. [Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Hendrix, Laura H. [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Bainbridge, John [Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Wang, Andrew Z. [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Nielsen, Matthew E. [Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); and others

2014-02-01T23:59:59.000Z

375

Workshop overview: Arsenic research and risk assessment  

SciTech Connect (OSTI)

The chronic exposure of humans through consumption of high levels of inorganic arsenic (iAs)-contaminated drinking water is associated with skin lesions, peripheral vascular disease, hypertension, and cancers. Additionally, humans are exposed to organic arsenicals when used as pesticides and herbicides (e.g., monomethylarsonic acid, dimethylarsinic acid (DMA{sup V}) also known as cacodylic acid). Extensive research has been conducted to characterize the adverse health effects that result from exposure to iAs and its metabolites to describe the biological pathway(s) that lead to adverse health effects. To further this effort, on May 31, 2006, the United States Environmental Protection Agency (USEPA) sponsored a meeting entitled 'Workshop on Arsenic Research and Risk Assessment'. The invited participants from government agencies, academia, independent research organizations and consultants were asked to present their current research. The overall focus of these research efforts has been to determine the potential human health risks due to environmental exposures to arsenicals. Pursuant in these efforts is the elucidation of a mode of action for arsenicals. This paper provides a brief overview of the workshop goals, regulatory context for arsenical research, mode of action (MOA) analysis in human health risk assessment, and the application of MOA analysis for iAs and DMA{sup V}. Subsequent papers within this issue will present the research discussed at the workshop, ensuing discussions, and conclusions of the workshop.

Sams, Reeder [Integrated Risk Information System Program, National Center for Environmental Assessment, MC: B-243 01, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711 (United States)], E-mail: sams.reeder@epa.gov; Wolf, Douglas C. [Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711 (United States); Ramasamy, Santhini; Ohanian, Ed [Health and Ecological Criteria Division, Office of Science and Technology, Office of Water, United States Environmental Protection Agency, Washington, DC 20460 (United States); Chen, Jonathan [Antimicrobials Division, Office of Pesticide Programs, United States Environmental Protection Agency, Washington, DC 20460 (United States); Lowit, Anna [Health Effects Division, Office of Pesticide Programs, United States Environmental Protection Agency, Washington, DC 20460 (United States)

2007-08-01T23:59:59.000Z

376

Evaluation of the {sup 4}I{sub 11/2} terminal level lifetime for several neodymium-doped laser crystals and glasses  

SciTech Connect (OSTI)

All models of lasing action require knowledge of the physical parameters involved, of which many can be measured or estimated. The value of the terminal level lifetime is an important parameter in modeling many high power laser systems since the terminal level lifetime can have a substantial impact on the extraction efficiency of the system. However, the values of the terminal level lifetimes for a number of important laser materials such as ND:YAG and ND:YLF are not well known. The terminal level lifetime, a measure of the time it takes for the population to drain out of the terminal (lower) lasing level, has values that can range from picoseconds to microseconds depending on the host medium, thus making it difficult to construct one definitive experiment for all materials. Until recently, many of the direct measurements of the terminal level lifetime employed complex energy extraction or gain recovery methods coupled with a numerical model which often resulted in large uncertainties in the measured lifetimes. In this report we demonstrate a novel and more accurate approach which employs a pump-probe technique to measure the terminal level lifetime of 16 neodymium-doped materials. An alternative yet indirect method, which is based on the ``Energy Gap Law,`` is to measure the nonradiative lifetime of another transition which has the same energy gap as the transition of the terminal level lifetime. Employing this simpler approach, we measured the lifetime for 30 neodymium-doped materials. We show for the first time a direct comparison between the two methods and determine that the indirect method can be used to infer the terminal level lifetime within a factor of two for most neodymium-doped glasses and crystals.

Bibeau, C.

1995-04-25T23:59:59.000Z

377

Radiative lifetimes of the alkaline earth monohalides Paul J. Dagdigian, Howard W. Cruse*, and Richard N. Zare  

E-Print Network [OSTI]

standard deviation, are given in parentheses. The lifetimes of the caX and SrX states are seen moments. Por the X, A, and B states of CaX and SrX, the nonbonding orbital is primarily n s 0", n p 11

Zare, Richard N.

378

Energy Consumption in Wireless Sensor Networks is a fundamental issue in terms of functionality and network lifetime. Minimization  

E-Print Network [OSTI]

ABSTRACT Energy Consumption in Wireless Sensor Networks is a fundamental issue in terms of functionality and network lifetime. Minimization of energy consumption by applying optimization techniques setup. Application driven profiling of energy consumption at the node level is a useful tool for optimal

Vouyioukas, Demosthenes

379

Measurement of the [bar over B][0 over s] Meson Lifetime in D[+ over s]?[superscript ?] Decays  

E-Print Network [OSTI]

We present a measurement of the ratio of the [bar over B][0 over s] meson lifetime, in the flavor-specific decay to D[+ over s]?[superscript ?], to that of the [bar over B][superscript 0] meson. The pp collision data used ...

Aaij, R.

380

Measurements and calculations of metastable level lifetimes in Fe X, Fe XI, Fe XII, Fe XIII, and Fe XIV  

E-Print Network [OSTI]

Lifetimes of metastable levels in the ground term of Fe ions within the 3s(2)3p(k), k=1-5, isoelectronic sequences have been measured. These measurements were performed utilizing ions that were selected by mass to charge ratio while transported from...

Moehs, D. P.; Bhatti, M. I.; Church, David A.

2001-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Dependence of nuclear spin singlet lifetimes on RF spin-locking power Stephen J. DeVience a,  

E-Print Network [OSTI]

Dependence of nuclear spin singlet lifetimes on RF spin-locking power Stephen J. DeVience a: Received 6 January 2012 Revised 14 March 2012 Available online 28 March 2012 Keywords: Nuclear singlet of long-lived nuclear spin singlet states as a function of the strength of the RF spin-locking field

Rosen, Matthew S

382

Prediction of the Creep-Fatigue Lifetime of Alloy 617: An Application of Non-destructive Evaluation and Information Integration  

SciTech Connect (OSTI)

A relatively simple method using the nominal constant average stress information and the creep rupture model is developed to predict the creep-fatigue lifetime of Alloy 617, in terms of time to rupture. The nominal constant average stress is computed using the stress relaxation curve. The predicted time to rupture can be converted to number of cycles to failure using the strain range, the strain rate during each cycle, and the hold time information. The predicted creep-fatigue lifetime is validated against the experimental measurements of the creep-fatigue lifetime collected using conventional laboratory creep-fatigue tests. High temperature creep-fatigue tests of Alloy 617 were conducted in air at 950°C with a tensile hold period of up to 1800s in a cycle at total strain ranges of 0.3% and 0.6%. It was observed that the proposed method is conservative in that the predicted lifetime is less than the experimentally determined values. The approach would be relevant to calculate the remaining useful life to a component like a steam generator that might fail by the creep-fatigue mechanism.

Vivek Agarwal; Richard Wright; Timothy Roney

2014-08-01T23:59:59.000Z

383

Lifetime studies of 130nm nMOS transistors intended for long-duration, cryogenic high-energy physics experiments.  

SciTech Connect (OSTI)

Future neutrino physics experiments intend to use unprecedented volumes of liquid argon to fill a time projection chamber in an underground facility. To increase performance, integrated readout electronics should work inside the cryostat. Due to the scale and cost associated with evacuating and filling the cryostat, the electronics will be unserviceable for the duration of the experiment. Therefore, the lifetimes of these circuits must be well in excess of 20 years. The principle mechanism for lifetime degradation of MOSFET devices and circuits operating at cryogenic temperatures is via hot carrier degradation. Choosing a process technology that is, as much as possible, immune to such degradation and developing design techniques to avoid exposure to such damage are the goals. This requires careful investigation and a basic understanding of the mechanisms that underlie hot carrier degradation and the secondary effects they cause in circuits. In this work, commercially available 130nm nMOS transistors operating at cryogenic temperatures are investigated. The results show that the difference in lifetime for room temperature operation and cryogenic operation for this process are not great and the lifetimes at both 300K and at 77K can be projected to more than 20 years at the nominal voltage (1.5V) for this technology.

Hoff, J.R.; /Fermilab; Arora, R.; Cressler, J.D.; /Georgia Tech; Deptuch, G.W.; /Fermilab; Gui, P.; /Southern Methodist U.; Lourenco, N.E.; /Georgia Tech; Wu, G.; /Southern Methodist U.; Yarema, R.J.; /Fermilab

2011-12-01T23:59:59.000Z

384

Improving the lifetime performance of ceramic fuel cells Fuel cells generate electricity from fuels more efficiently and with  

E-Print Network [OSTI]

to the development of low-cost, modular and fuel-flexible solid oxide fuel cell technology. #12;2014 Improving the lifetime performance of ceramic fuel cells Fuel cells generate electricity from fuels more efficiently and with fewer emissions per watt than burning fossil fuels. But as fuel cells

Rollins, Andrew M.

385

Long lifetime, low intensity light source for use in nighttime viewing of equipment maps and other writings  

DOE Patents [OSTI]

A long-lifetime light source with sufficiently low intensity to be used for reading a map or other writing at nighttime, while not obscuring the user's normal night vision. This light source includes a diode electrically connected in series with a small power source and a lens properly positioned to focus at least a portion of the light produced by the diode.

Frank, Alan M. (Livermore, CA); Edwards, William R. (Modesto, CA)

1983-01-01T23:59:59.000Z

386

IEEE TVLSI SPECIAL SECTION ON LOW POWER ELECTRONICS AND DESIGN 2007 1 Maximizing the Lifetime of Embedded Systems  

E-Print Network [OSTI]

of Embedded Systems Powered by Fuel Cell-Battery Hybrids Jianli Zhuo, Student Member, IEEE, Chaitali, and Sarma Vrudhula, Senior Member, IEEE Abstract--Fuel cell (FC) is a viable alternative power source capabilities. In this work, we consider the problem of extending the lifetime of a fuel-cell-based hybrid

Kambhampati, Subbarao

387

Hydrogen Bond Lifetimes and Energetics for Solute/Solvent Complexes Studied with 2D-IR Vibrational Echo Spectroscopy  

E-Print Network [OSTI]

Hydrogen Bond Lifetimes and Energetics for Solute/Solvent Complexes Studied with 2D-IR Vibrational@stanford.edu Abstract: Weak hydrogen-bonded solute/solvent complexes are studied with ultrafast two the dissociation and formation rates of the hydrogen-bonded complexes. The dissociation rates of the weak hydrogen

Fayer, Michael D.

388

306 IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS, VOL. 25, NO. 2, FEBRUARY 2007 Lifetime Maximization via Cooperative Nodes and  

E-Print Network [OSTI]

locations and energy levels among distributed nodes. First, a lifetime maximization problem via cooperative is with the Department of Electrical and Computer Engineer- ing and the Institute for Systems Research, University of Maryland, College Park, MD 20742 USA (email: kjrliu@eng.umd.edu). Z. Han is with the Department

Liu, K. J. Ray

389

Waste management health risk assessment: A case study of a solid waste landfill in South Italy  

SciTech Connect (OSTI)

An integrated risk assessment study has been performed in an area within 5 km from a landfill that accepts non hazardous waste. The risk assessment was based on measured emissions and maximum chronic population exposure, for both children and adults, to contaminated air, some foods and soil. The toxic effects assessed were limited to the main known carcinogenic compounds emitted from landfills coming both from landfill gas torch combustion (e.g., dioxins, furans and polycyclic aromatic hydrocarbons, PAHs) and from diffusive emissions (vinyl chloride monomer, VCM). Risk assessment has been performed both for carcinogenic and non-carcinogenic effects. Results indicate that cancer and non-cancer effects risk (hazard index, HI) are largely below the values accepted from the main international agencies (e.g., WHO, US EPA) and national legislation ( and ).

Davoli, E., E-mail: enrico.davoli@marionegri.i [Istituto di Ricerche Farmacologiche 'Mario Negri', Environmental Health Sciences Department, Via Giuseppe La Masa 19, 20156 Milano (Italy); Fattore, E.; Paiano, V.; Colombo, A.; Palmiotto, M. [Istituto di Ricerche Farmacologiche 'Mario Negri', Environmental Health Sciences Department, Via Giuseppe La Masa 19, 20156 Milano (Italy); Rossi, A.N.; Il Grande, M. [Progress S.r.l., Via Nicola A. Porpora 147, 20131 Milano (Italy); Fanelli, R. [Istituto di Ricerche Farmacologiche 'Mario Negri', Environmental Health Sciences Department, Via Giuseppe La Masa 19, 20156 Milano (Italy)

2010-08-15T23:59:59.000Z

390

Rethinking Risk: Aspiration as Pure Risk  

E-Print Network [OSTI]

of an environmental decision problem where di¤erent investment packages (acts) lead to di¤erent possible levels of global wealth and overall levels of global warming. Avoiding the all too easy economic assumption that the global wealth levels can simply be adjusted... by some amount to re‡ect the e¤ect of the global temperature levels, we are now left with two numerical components in this problem. There are thus separate measures of risk aversion that deal with wealth and temperature, and therefore two di¤erent concepts...

Davies, Greg B

2006-03-14T23:59:59.000Z

391

Lessons learned: Needs for improving human health risk assessment at USDOE Sites  

SciTech Connect (OSTI)

Realistic health risk assessments were performed in a pilot study of three U.S. Department of Energy (USDOE) sites. These assessments, covering a broad spectrum of data and methods, were used to identify needs for improving future health risk assessments at USDOE sites. Topics receiving specific recommendations for additional research include: choice of distributions for Monte Carlo simulation; estimation of risk reduction; analysis of the U.S. Department of Agriculture Database on food and nutrient intakes; investigations on effects of food processing on contaminant levels; background food and environmental concentrations of contaminants; method for handling exposures to groundwater plumes, methods for analyzing less than lifetime exposure to carcinogens; and improvement of bioaccumulation factors.

Hamilton, L.D.; Holtzman, S.; Meinhold, A.F.; Morris, S.C.; Rowe, M.D. [Brookhaven National Lab., Upton, NY (United States); Daniels, J.I.; Layton, D.W.; Anspaugh, L.R. [Lawrence Livermore National Lab., CA (United States)

1993-09-01T23:59:59.000Z

392

Molecular Markers of Lung Cancer in MAYAK Workers  

SciTech Connect (OSTI)

The molecular mechanisms that result in the elevated risk for lung cancer associated with exposure to radiation have not been well characterized. Workers from the MAYAK nuclear enterprise are an ideal cohort in which to study the molecular epidemiology of cancer associated with radiation exposure and to identify the genes targeted for inactivation that in turn affect individual risk for radiation-induced lung cancer. Epidemiology studies of the MAYAK cohort indicate a significantly higher frequency for adenocarcinoma and squamous cell carcinoma (SCC) in workers than in a control population and a strong correlation between these tumor types and plutonium exposure. Two hypotheses will be evaluated through the proposed studies. First, radiation exposure targets specific genes for inactivation by promoter methylation. This hypothesis is supported by our recent studies with the MAYAK population that demonstrated the targeting of the p16 gene for inactivation by promoter methylation in adenocarcinomas from workers (1). Second, genes inactivated in tumors can serve as biomarkers for lung cancer risk in a cancer-free population of workers exposed to plutonium. Support for this hypothesis is based on exciting preliminary results of our nested, case-control study of persons from the Colorado cohort. In that study, a panel of methylation markers for predicting lung cancer risk is being evaluated in sputum samples from incident lung cancer cases and controls. The first hypothesis will be tested by determining the prevalence for promoter hypermethylation of a panel of genes shown to play a critical role in the development of either adenocarcinoma and/or SCC associated with tobacco. Our initial studies on adenocarcinoma in MAYAK workers will be extended to evaluate methylation of the PAX5 {alpha}, PAX5 {beta}, H-cadherin, GATA5, and bone morphogenesis 3B (BMP3B) genes in the original sample set described under Preliminary studies. In addition, studies will be initiated in SCC from workers and controls to identify genes targeted for inactivation by plutonium in this other common histologic form of lung cancer. We will examine methylation of the p16, O{sup 6}-methylguanine-DNA methyl-transferase (MGMT), and death associated protein kinase genes ([DAP-K], evaluated previously in adenocarcinomas) as well as the new genes being assessed in the adenocarcinomas. The second hypothesis will be tested in a cross-sectional study of cancer-free workers exposed to plutonium and an unexposed population. A cohort of 700 cancer-free workers and 700 unexposed persons is being assembled, exposures are being defined, and induced sputum collected at initial entry into the study and approximately 1-year later. Exposed and unexposed persons will be matched by 5-year age intervals and smoking status (current and former). The frequency for methylation of four genes that show the greatest difference in prevalence in tumors from workers and controls will be determined in exfoliated cells within sputum. These studies will extend those in primary tumors to determine whether difference in prevalence for individual or multiple genes are detected in sputum samples from high-risk subjects exposed to plutonium. Follow-up of this cohort offers the opportunity to validate these endpoints and future biomarkers as true markers for lung cancer risk.

Steven A. Belinsky, PhD

2007-02-15T23:59:59.000Z

393

Pest Risk Analysis for Hymenoscyphus  

E-Print Network [OSTI]

Pest Risk Analysis for Hymenoscyphus pseudoalbidus for the UK and the Republic of Ireland #12;2 PRA for Hymenoscyphus pseudoalbidus C.E. Sansford 23rd May 2013 Pest Risk Analysis Pest Risk Analysis for Hymenoscyphus (Kowalski and Holdenrieder, 2009). 1 Please cite this document as: Sansford, CE (2013). Pest Risk Analysis

394

Fluorescence lifetimes and linewidths of dye in photonic crystals Mischa Megens, Judith E. G. J. Wijnhoven, Ad Lagendijk, and Willem L. Vos*  

E-Print Network [OSTI]

Fluorescence lifetimes and linewidths of dye in photonic crystals Mischa Megens, Judith E. G. J fluorescence lifetimes of dye incorporated in high-quality photonic crystals, made of colloidal spheres in a cavity. The effects of homogeneous and inhomogeneous broadening of the emission spectrum of dye inside

Vos, Willem L.

395

JOURNAL DE PHYSIQUE Colloque C7, supplement au n 12, Tome 37, Decembre 1976, page C7-359 CATIONIC HEATS OF TRANSPORT AND VACANCY LIFETIMES  

E-Print Network [OSTI]

HEATS OF TRANSPORT AND VACANCY LIFETIMES IN SINGLE CRYSTALS OF SODIUM CHLORIDE AND POTASSIUM CHLORIDE A on resistance along with corresponding driving forces provides a means for estimation of vacancy lifetimes of this experimental work. Theory. -- In a material at equilibrium, vacancies are produced and annihilated at a rate

Paris-Sud XI, Université de

396

Positron lifetime in vacancy-impurity complexes (*) Section d'Etudes des Solides Irradis, Centre d'Etudes Nuclaires, Boite Postale n 6, 92260 Fontenay aux Roses, France  

E-Print Network [OSTI]

L-547 Positron lifetime in vacancy-impurity complexes (*) C. Corbel Section d'Etudes des Solides positon. Abstract. 2014 We calculate the positron lifetime in vacancy-solute (Na, Mg, Zn) complexes in Al of the same order as for the divacancy. These results indicate that vacancy complexes and vacancy

Boyer, Edmond

397

Estimated human health risks of disposing of nonhazardous oil field waste in salt caverns  

SciTech Connect (OSTI)

Argonne National Laboratory (ANL) has completed an evaluation of the possibility that adverse human health effects (carcinogenic and noncarcinogenic) could result from exposure to contaminants released from nonhazardous oil field wastes (NOW) disposed in domal salt caverns. In this assessment, several steps were used to evaluate potential human health risks: identifying potential contaminants of concern, determining how humans could be exposed to these contaminants, assessing the contaminants` toxicities, estimating contaminant intakes, and, finally, calculating human cancer and noncancer risks.

Tomasko, D.; Elcock, D.; Veil, J.

1997-09-01T23:59:59.000Z

398

QUESTIONS & ANSWERS ABOUT LUNG CANCER  

E-Print Network [OSTI]

QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

399

A Reanalysis of Curvature in the Dose Response for Cancer and Modifications by Age at Exposure Following Radiation Therapy for Benign Disease  

SciTech Connect (OSTI)

Purpose: To assess the shape of the dose response for various cancer endpoints and modifiers by age and time. Methods and Materials: Reanalysis of the US peptic ulcer data testing for heterogeneity of radiogenic risk by cancer endpoint (stomach, pancreas, lung, leukemia, all other). Results: There are statistically significant (P<.05) excess risks for all cancer and for lung cancer and borderline statistically significant risks for stomach cancer (P=.07), and leukemia (P=.06), with excess relative risks Gy{sup -1} of 0.024 (95% confidence interval [CI] 0.011, 0.039), 0.559 (95% CI 0.221, 1.021), 0.042 (95% CI -0.002, 0.119), and 1.087 (95% CI -0.018, 4.925), respectively. There is statistically significant (P=.007) excess risk of pancreatic cancer when adjusted for dose-response curvature. General downward curvature is apparent in the dose response, statistically significant (P<.05) for all cancers, pancreatic cancer, and all other cancers (ie, other than stomach, pancreas, lung, leukemia). There are indications of reduction in relative risk with increasing age at exposure (for all cancers, pancreatic cancer), but no evidence for quadratic variations in relative risk with age at exposure. If a linear-exponential dose response is used, there is no significant heterogeneity in the dose response among the 5 endpoints considered or in the speed of variation of relative risk with age at exposure. The risks are generally consistent with those observed in the Japanese atomic bomb survivors and in groups of nuclear workers. Conclusions: There are excess risks for various malignancies in this data set. Generally there is a marked downward curvature in the dose response and significant reduction in relative risk with increasing age at exposure. The consistency of risks with those observed in the Japanese atomic bomb survivors and in groups of nuclear workers implies that there may be little sparing effect of fractionation of dose or low-dose-rate exposure.

Little, Mark P., E-mail: mark.little@nih.gov [Radiation Epidemiology Branch, National Cancer Institute, Rockville, Maryland (United States); Stovall, Marilyn; Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kleinerman, Ruth A. [Radiation Epidemiology Branch, National Cancer Institute, Rockville, Maryland (United States)] [Radiation Epidemiology Branch, National Cancer Institute, Rockville, Maryland (United States)

2013-02-01T23:59:59.000Z

400

ITER risk workshop participant guide  

SciTech Connect (OSTI)

The goal of planning risk management is to make everyone involved in a program aware that risk should be a consideration in the design, development, and fielding of a system. Risk planning is a tool to assess and mitigate events that might adversely impact the program. Therefore, risk management increases the probability/likelihood of program success and can help to avoid program crisis management and improve problem solving by managing risk early in the acquisition cycle.

Medina, Patricia [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Arsenic exposure, smoking, and lung cancer in smelter workers--a case-control study  

SciTech Connect (OSTI)

A cohort of 3,916 Swedish copper smelter workers employed for at least 3 months between 1928 and 1967 was followed up through 1981. Arsenic exposure was estimated for different time periods at each workplace within the smelter. Detailed job records were linked to the exposure matrix, thus forming individual cumulative arsenic exposure measures for each smelter worker. Smoking history was collected for 107 lung cancer cases and 214 controls from the cohort. Lung cancer risks were positively related to cumulative arsenic exposure with smoking standardized relative risks ranging from 0.7 to 8.7 in different exposure groups. A negative confounding by smoking was suggested in the higher exposure categories. The interaction between arsenic and smoking for the risk of developing lung cancer was intermediate between additive and multiplicative and appeared less pronounced among heavy smokers.

Jaerup, L.P.; Pershagen, G. (Department of Environmental Hygiene, Karolinska Institutet, Stockholm (Sweden))

1991-09-15T23:59:59.000Z

402

Comparison of Minority Carrier Lifetime Measurements in Superstrate and Substrate CdTe PV Devices: Preprint  

SciTech Connect (OSTI)

We discuss typical and alternative procedures to analyze time-resolved photoluminescence (TRPL) measurements of minority carrier lifetime (MCL) with the hope of enhancing our understanding of how this technique may be used to better analyze CdTe photovoltaic (PV) device functionality. Historically, TRPL measurements of the fast recombination rate (t1) have provided insightful correlation with broad device functionality. However, we have more recently found that t1 does not correlate as well with smaller changes in device performance, nor does it correlate well with performance differences observed between superstrate and substrate CdTe PV devices. This study presents TRPL data for both superstrate and substrate CdTe devices where both t1 and the slower TRPL decay (t2) are analyzed. The study shows that changes in performance expected from small changes in device processing may correlate better with t2. Numerical modeling further suggests that, for devices that are expected to have similar drift field in the depletion region, effects of changes in bulk MCL and interface recombination should be more pronounced in t2. Although this technique may provide future guidance to improving CdS/CdTe device performance, it is often difficult to extract statistically precise values for t2, and therefore t2 data may demonstrate significant scatter when correlated with performance parameters.

Gessert, T. A.; Dhere, R. G.; Duenow, J. N.; Kuciauskas, D.; Kanevce, A.; Bergeson, J. D.

2011-07-01T23:59:59.000Z

403

Comparison of Minority Carrier Lifetime Measurements in Superstrate and Substrate CdTe PV Devices  

SciTech Connect (OSTI)

We discuss typical and alternative procedures to analyze time-resolved photoluminescence (TRPL) measurements of minority carrier lifetime (MCL) with the hope of enhancing our understanding of how this technique may be used to better analyze CdTe photovoltaic (PV) device functionality. Historically, TRPL measurements of the fast recombination rate (t{sub 1}) have provided insightful correlation with broad device functionality. However, we have more recently found that t{sub 1} does not correlate as well with smaller changes in device performance, nor does it correlate well with performance differences observed between superstrate and substrate CdTe PV devices. This study presents TRPL data for both superstrate and substrate CdTe devices where both t{sub 1} and the slower TRPL decay (t{sub 2}) are analyzed. The study shows that changes in performance expected from small changes in device processing may correlate better with t{sub 2}. Numerical modeling further suggests that, for devices that are expected to have similar drift field in the depletion region, effects of changes in bulk MCL and interface recombination should be more pronounced in t{sub 2}. Although this technique may provide future guidance to improving CdS/CdTe device performance, it is often difficult to extract statistically precise values for t{sub 2}, and therefore t{sub 2} data may demonstrate significant scatter when correlated with performance parameters.

Gessert, T. A.; Dhere, R. G.; Duenow, J. N.; Kuciauskas, D.; Kanevce, A.; Bergeson, J. D.

2011-01-01T23:59:59.000Z

404

THE LIFETIME OF PROTOPLANETARY DISKS IN A LOW-METALLICITY ENVIRONMENT  

SciTech Connect (OSTI)

The extreme outer Galaxy (EOG), the region with a Galactic radius of more than 18 kpc, is known to have a very low metallicity, about one-tenth that of the solar neighborhood. We obtained the deep near-infrared (NIR) images of two very young (approx0.5 Myr) star-forming clusters that are two of the most distant embedded clusters in the EOG. We find that in both clusters the fraction of stars with NIR excess, which originates from the circumstellar dust disk at radii of <=0.1 AU, is significantly lower than those in the solar neighborhood. Our results suggest that most of the stars forming in the low-metallicity environment experience disk dispersal at an earlier stage (<1 Myr) than those forming in the solar metallicity environment (as much as approx5-6 Myr). Such a rapid disk dispersal may make the formation of planets difficult, and the shorter disk lifetime with a lower metallicity, could contribute to the strong metallicity dependence of the well-known 'planet-metallicity correlation', which states that the probability of a star hosting a planet increases steeply with stellar metallicity. The reason for the rapid disk dispersal could be the increase of the mass accretion rate and/or the effective far-ultraviolet photoevaporation due to the low extinction; however, another unknown mechanism for the EOG environment could be contributing significantly.

Yasui, Chikako; Kobayashi, Naoto [Institute of Astronomy, School of Science, University of Tokyo, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Tokunaga, Alan T. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Saito, Masao [ALMA Project, National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Tokoku, Chihiro, E-mail: ck_yasui@ioa.s.u-tokyo.ac.j [Astronomical Institute, Tohoku University, Aramaki, Aoba, Sendai 980-8578 (Japan)

2009-11-01T23:59:59.000Z

405

Lifetime Prediction for Degradation of Solar Mirrors using Step-Stress Accelerated Testing (Presentation)  

SciTech Connect (OSTI)

This research is to illustrate the use of statistical inference techniques in order to quantify the uncertainty surrounding reliability estimates in a step-stress accelerated degradation testing (SSADT) scenario. SSADT can be used when a researcher is faced with a resource-constrained environment, e.g., limits on chamber time or on the number of units to test. We apply the SSADT methodology to a degradation experiment involving concentrated solar power (CSP) mirrors and compare the results to a more traditional multiple accelerated testing paradigm. Specifically, our work includes: (1) designing a durability testing plan for solar mirrors (3M's new improved silvered acrylic "Solar Reflector Film (SFM) 1100") through the ultra-accelerated weathering system (UAWS), (2) defining degradation paths of optical performance based on the SSADT model which is accelerated by high UV-radiant exposure, and (3) developing service lifetime prediction models for solar mirrors using advanced statistical inference. We use the method of least squares to estimate the model parameters and this serves as the basis for the statistical inference in SSADT. Several quantities of interest can be estimated from this procedure, e.g., mean-time-to-failure (MTTF) and warranty time. The methods allow for the estimation of quantities that may be of interest to the domain scientists.

Lee, J.; Elmore, R.; Kennedy, C.; Gray, M.; Jones, W.

2011-09-01T23:59:59.000Z

406

NGNP Risk Management Database: A Model for Managing Risk  

SciTech Connect (OSTI)

The Next Generation Nuclear Plant (NGNP) Risk Management System (RMS) is a database used to maintain the project risk register. The RMS also maps risk reduction activities to specific identified risks. Further functionality of the RMS includes mapping reactor suppliers Design Data Needs (DDNs) to risk reduction tasks and mapping Phenomena Identification Ranking Table (PIRTs) to associated risks. This document outlines the basic instructions on how to use the RMS. This document constitutes Revision 1 of the NGNP Risk Management Database: A Model for Managing Risk. It incorporates the latest enhancements to the RMS. The enhancements include six new custom views of risk data - Impact/Consequence, Tasks by Project Phase, Tasks by Status, Tasks by Project Phase/Status, Tasks by Impact/WBS, and Tasks by Phase/Impact/WBS.

John Collins; John M. Beck

2011-11-01T23:59:59.000Z

407

Consumption of PCB-contaminated sport fish and risk of spontaneous fetal death  

SciTech Connect (OSTI)

Spontaneous fetal death has been observed among various mammalian species after exposure to polychlorinated biphenyls (PCBs). Our exposure-based cohort study assessed the relationship between consumption of PCB-contaminated Lake Ontario sport fish and spontaneous fetal death using 1820 multigravid fertile women from the 1990-1991 New York State Angler Cohort Study. Fish consumption data were obtained from food frequency questionnaires and history of spontaneous fetal death from live birth certificates. Analyses were stratified by number of prior pregnancies and controlled for smoking and maternal age. No significant increases in risk for fetal death were observed across four measures of exposure: a lifetime estimate of PCB exposure based on species-specific PCB levels; the number of years of fish consumption; kilograms of sport fish consumed in 1990-1991; and a lifetime estimate of kilograms eaten. A slight risk reduction was seen for women with two prior pregnancies at the highest level of PCB exposure (odds ratio = 0.36; 95% CI, 0.14-0.92) and for women with three or more prior pregnancies with increasing years of fish consumption (odds ratio = 0.97; 95% CI, 0.94-0.99). These findings suggest that consumption of PCB-contaminated sport fish does not increase the risk of spontaneous fetal death. 50 refs., 2 tabs.

Mendola, P.; Buck, G.M.; Vena, J.E.; Zielezny, M. [State Univ. of New York, Buffalo, NY (United States); Sever, L.E. [Battelle Seattle Research Center, WA (United States)

1995-05-01T23:59:59.000Z

408

Health risks in perspective: Judging health risks of energy technologies  

SciTech Connect (OSTI)

Almost daily, Americans receive reports from the mass news media about some new and frightening risk to health and welfare. Most such reports emphasize the newsworthiness of the risks -- the possibility of a crisis, disagreements among experts, how things happened, who is responsible for fixing them, how much will it cost, conflict among parties involved, etc. As a rule, the magnitudes of the risks, or the difficulty of estimating those magnitudes, have limited newsworthiness, and so they are not mentioned. Because of this emphasis in the news media, most people outside the risk assessment community must judge the relative significance of the various risks to which we all are exposed with only that information deemed newsworthy by reporters. This information is biased and shows risks in isolation. There is no basis for understanding and comparing the relative importance of risks among themselves, or for comparing one risk, perhaps a new or newly-discovered one, in the field of all risks. The purpose of this report is to provide perspective on the various risks to which we are routinely exposed. It serves as a basis for understanding the meaning of quantitative risk estimates and for comparing new or newly-discovered risks with other, better-understood risks. Specific emphasis is placed on health risks of energy technologies.

Rowe, M.D.

1992-09-18T23:59:59.000Z

409

Risk assessment in the DOE Assurance Program for Remedial Action  

SciTech Connect (OSTI)

This document provides information obtained during the performance of risk assessment tasks in support of the Assurance Program for Remedial Action (APRA) sponsored by the Office of Operational Safety of the Department of Energy. We have presented a method for the estimation of projected health effects at properties in the vicinity of uranium mill tailing piles due to transported tailings or emissions from the piles. Because radon and radon daughter exposure is identified as the principal factor contributing to health effects at such properties, the basis for estimating lung cancer risk as a result of such exposure is discussed in detail. Modeling of health risk due to a secondary pathway, ingestion of contaminated, home-grown food products, is also discussed since it is a potentially important additional source of exposure in certain geographic locations. Risk assessment methods used in various mill tailings reports are reviewed. The protocols for radiological surveys conducted in DOE-sponsored remedial action programs are critically reviewed with respect to their relevance to the needs of health risk estimation. The relevance of risk assessment to the APRA program is discussed briefly.

Marks, S.; Cross, F.T.; Denham, D.H.; Kennedy, W.E.; Stenner, R.D.

1985-08-01T23:59:59.000Z

410

E-Print Network 3.0 - ar-negative prostate cancers Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer Summary: --22000000 58 Prostate cancer Prostate cancer...

411

The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer  

E-Print Network [OSTI]

THE PROTECTIVE EFFECTS OF ESTRADIOL ON SPORADIC AND INFLAMMATION-ASSOCIATED COLON CANCER A Dissertation by CAMERON MICHELLE ARMSTRONG Submitted to the Office of Graduate and Professional Studies of Texas A&M University... Major Subject: Nutrition Copyright 2013 Cameron M. Armstrong ii ABSTRACT Epidemiological studies suggest pre-menopausal women have a reduced risk for sporadic and inflammation-associated colon cancer compared to post-menopausal women and men...

Armstrong, Cameron Michelle

2013-11-22T23:59:59.000Z

412

Volumetric Mammographic Density: Heritability and Association With Breast Cancer Susceptibility Loci  

E-Print Network [OSTI]

was estimated by fitting variance-component models as implemented in the Sequential Oligogenic Linkage Analysis Routines package (SOLAR, version 7.2.5.) (33,34). This approach is based on maximum likelihood estimation of a linear mixed-effects model... Cormack VA, Highnam RP, et al. Screen-film mammographic density and breast cancer risk: a comparison of the volumetric standard mammogram form and the interactive threshold measurement methods. Cancer Epidemiol Biomarkers Prev. 2010;19(2):418-428. 23...

Brand, Judith S.; Humphreys, Keith; Thompson, Deborah J.; Li, Jingmei; Eriksson, Mikael; Czene, Kamila

2014-09-15T23:59:59.000Z

413

A genome-wide association scan on estrogen receptor -negative breast cancer  

E-Print Network [OSTI]

in this study. The discovery stage consists of cases and controls from Finland and Sweden. The vali- dation stage consists of breast cancer cases from two further studies: the Study of Epidemiology and Risk fac- tors in Cancer Heredity (SEARCH) and Rotterdam... genotype, an indicator variable speci- fying country (Sweden and Finland), and interaction effects of Eigen values of PCs × country specified in such a way that country-specific PCs were implemented for the relevant subjects. Quantile-quantile plots were...

Li, Jingmei; Humphreys, Keith; Darabi, Hatef; Rosin, Gustaf; Hannelius, Ulf; Heikkinen, Tuomas; Aittomaki, Kristiina; Blomqvist, Carl; Pharoah, Paul D P; Dunning, Alison M; Ahmed, Shahana; Hooning, Maartje J; Hollestelle, Antoinette; Oldenburg, Rogier A; Alfredsson, Lars; Palotie, Aarno; Peltonen-Palotie, Leena; Irwanto, Astrid K; Low, Hui Qi; Teoh, Garrett H K; Thalamuthu, Anbupalam; Kere, Juha; D'Amato, Mauro; Easton, Douglas F; Nevanlinna, Heli; Liu, Jianjun; Czene, Kamila; Hall, Per

2010-11-09T23:59:59.000Z

414

Aneuploidy: Cancer's Fatal Flaw?  

E-Print Network [OSTI]

Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we ...

Williams, Bret R.

415

17(lowercase beta)-estradiol and Tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice  

E-Print Network [OSTI]

Helicobacter pylori infection promotes male predominant gastric adenocarcinoma in humans. Estrogens reduce gastric cancer risk and previous studies showed that prophylactic 17?-estradiol (E2) in INS-GAS mice decreases H. ...

Sheh, Alexander

416

Essays on risk aversion  

E-Print Network [OSTI]

more risk averse than v. Fix s, and let av be the value that maximizes v's expected utility. Assume, without loss of generality, that u(w ? c(av)) = v(w ? c(av)) = 1 and that u(w ? D(s) ? c(av...

Jindapon, Paan

2006-10-30T23:59:59.000Z

417

Risk Management Guide  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This Guide provides a framework for identifying and managing key technical, schedule, and cost risks through applying the requirements of DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, dated 7-28-06. Canceled by DOE G 413.3-7A, dated 1-12-11. Does not cancel other directives.

2008-09-16T23:59:59.000Z

418

Automated assessment of bilateral breast volume asymmetry as a breast cancer biomarker during mammographic screening  

SciTech Connect (OSTI)

The biological concept of bilateral symmetry as a marker of developmental stability and good health is well established. Although most individuals deviate slightly from perfect symmetry, humans are essentially considered bilaterally symmetrical. Consequently, increased fluctuating asymmetry of paired structures could be an indicator of disease. There are several published studies linking bilateral breast size asymmetry with increased breast cancer risk. These studies were based on radiologists manual measurements of breast size from mammographic images. We aim to develop a computerized technique to assess fluctuating breast volume asymmetry in screening mammograms and investigate whether it correlates with the presence of breast cancer. Using a large database of screening mammograms with known ground truth we applied automated breast region segmentation and automated breast size measurements in CC and MLO views using three well established methods. All three methods confirmed that indeed patients with breast cancer have statistically significantly higher fluctuating asymmetry of their breast volumes. However, statistically significant difference between patients with cancer and benign lesions was observed only for the MLO views. The study suggests that automated assessment of global bilateral asymmetry could serve as a breast cancer risk biomarker for women undergoing mammographic screening. Such biomarker could be used to alert radiologists or computer-assisted detection (CAD) systems to exercise increased vigilance if higher than normal cancer risk is suspected.

Williams, Alex C [ORNL; Hitt, Austin N [ORNL; Voisin, Sophie [ORNL; Tourassi, Georgia [ORNL

2013-01-01T23:59:59.000Z

419

Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer  

E-Print Network [OSTI]

Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program ­ Genetic Epidemiology of Cancer Associate Professor Tenuretrack Health is expanding research in Cancer Genetic Epidemiology to enrich an already robust campuswide

Weber, David J.

420

Inhibition of Aurora-kinases for Tailored Risk Adapted Treatment of Multiple Myeloma  

E-Print Network [OSTI]

Inhibition of Aurora-kinases for Tailored Risk Adapted Treatment of Multiple Myeloma Dirk Hose1 associated with Aurora-kinase expression in several cancer entities, including multiple myeloma. Therefore, the expression of Aurora-A, -B and -C was determined by Affymetrix DNA-microarrays in 784 samples including two

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Rethinking diagnostic delay in cancer: how difficult is the diagnosis?  

E-Print Network [OSTI]

for Health Services Research, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK; 2Health Behaviour Research Centre, University College London, London, UK; 3School of Medicine, Pharmacy and Health, University... U. Evaluation of risk assessment tools for suspected cancer in general practice: a cohort study. Br J Gen Pract 2013;63:e30-6. 23 Guldbrandt LM, Rasmussen TR, Rasmussen F, Vedsted P. Implementing direct access to low-dose computed tomography...

Lyratzopoulos, Georgios; Wardle, Jane; Rubin, Greg

2014-12-10T23:59:59.000Z

422

Measurement of the B+_c Meson Lifetime Using B+_c -->J/psi e+nu_e  

SciTech Connect (OSTI)

We present a measurement of the B{sub c}{sup +} meson lifetime in the decay mode B{sub c}{sup +}{yields}J/{psi}e{sup +}{nu}e using the Collider Detector at Fermilab II detector at the Fermilab Tevatron Collider. From a sample of about 360 pb{sup -1} of p{bar p} collisions at {radical}(s)=1.96 TeV, we reconstruct J/{psi}e{sup +} pairs with invariant mass in the kinematically allowed range 4lifetime of 0.463((+0.073)/(-0.065))(stat){+-}0.036(syst) ps.

Abulencia, A.; Budd, S.; Chu, P.H.; Ciobanu, C.I.; Errede, D.; Errede, S.; Gerberich, H.; Grundler, U.; Junk, T.R.; Kraus, J.; Liss,T.M.; Marino, C.; Pitts,K.; Rogers, E.; Taffard, A.; Veramendi, G.; Zhang, X.; Acosta, D.; Cruz, A.; Field, R.

2006-07-06T23:59:59.000Z

423

Measurement of the B(c)+ meson lifetime using B(c)+ ---> J/psi e+ nu(e)  

SciTech Connect (OSTI)

The authors present a measurement of the B{sub c}{sup +} meson lifetime in the semileptonic decay mode B{sub c}{sup +} {yields} J/{psi}e{sup +}{nu}{sub e} using the CDF II detector at the Fermilab Tevatron Collider. From a sample of about 360 pb{sup -1} of p{bar p} collisions at {radical}s = 1.96 TeV, they reconstruct J/{psi}e{sup +} pairs with invariant mass in the kinematically allowed range 4 < M{sub J/{psi}e} < 6 GeV/c{sup 2}. A fit to the decay-length distribution of 238 signal events yields a measured B{sub c}{sup +} meson lifetime of 0.463{sub -0.065}{sup +0.073}(stat) {+-} 0.036(syst) ps.

Abulencia, A.; Acosta, D.; Adelman, Jahred A.; Affolder, T.; Akimoto, T.; Albrow, M.G.; Ambrose, D.; Amerio, S.; Amidei, D.; Anastassov, A.; Anikeev, K.; /Taiwan, Inst.

2006-03-01T23:59:59.000Z

424

Precision measurement of the mass and lifetime of the $?_b^0$ baryon  

E-Print Network [OSTI]

Using a proton-proton collision data sample corresponding to an integrated luminosity of 3 fb$^{-1}$ collected by LHCb at center-of-mass energies of 7 and 8 TeV, about 3800 $\\Xi_b^0\\to\\Xi_c^+\\pi^-$, $\\Xi_c^+\\to pK^-\\pi^+$ signal decays are reconstructed. From this sample, the first measurement of the $\\Xi_b^0$ baryon lifetime is made, relative to that of the $\\Lambda_b^0$ baryon. The mass differences $M(\\Xi_b^0)-M(\\Lambda_b^0)$ and $M(\\Xi_c^+)-M(\\Lambda_c^+)$ are also measured with precision more than four times better than the current world averages. The resulting values are $\\frac{\\tau_{\\Xi_b^0}}{\\tau_{\\Lambda_b^0}} = 1.006\\pm0.018\\pm0.010$, $M(\\Xi_b^0) - M(\\Lambda_b^0) = 172.44\\pm0.39\\pm0.17 MeV/c^2$, $M(\\Xi_c^+) - M(\\Lambda_c^+) = 181.51\\pm0.14\\pm0.10 MeV/c^2$, where the first uncertainty is statistical and the second is systematic. The relative rate of $\\Xi_b^0$ to $\\Lambda_b^0$ baryon production is measured to be $\\frac{f_{\\Xi_b^0}}{f_{\\Lambda_b^0}}\\frac{{\\cal{B}}(\\Xi_b^0\\to\\Xi_c^+\\pi^-)}{{\\cal{B}}(\\Lambda_b^0\\to\\Lambda_c^+\\pi^-)}\\frac{{\\cal{B}}(\\Xi_c^+\\to pK^-\\pi^+)}{{\\cal{B}}(\\Lambda_c^+\\to pK^-\\pi^+)} = (1.88\\pm0.04\\pm0.03)\\times10^{-2}$, where the first factor is the ratio of fragmentation fractions, $b\\to\\Xi_b^0$ relative to $b\\to\\Lambda_b^0$. Relative production rates as functions of transverse momentum and pseudorapidity are also presented.

LHCb collaboration; R. Aaij; B. Adeva; M. Adinolfi; A. Affolder; Z. Ajaltouni; S. Akar; J. Albrecht; F. Alessio; M. Alexander; S. Ali; G. Alkhazov; P. Alvarez Cartelle; A. A. Alves Jr; S. Amato; S. Amerio; Y. Amhis; L. An; L. Anderlini; J. Anderson; R. Andreassen; M. Andreotti; J. E. Andrews; R. B. Appleby; O. Aquines Gutierrez; F. Archilli; A. Artamonov; M. Artuso; E. Aslanides; G. Auriemma; M. Baalouch; S. Bachmann; J. J. Back; A. Badalov; V. Balagura; W. Baldini; R. J. Barlow; C. Barschel; S. Barsuk; W. Barter; V. Batozskaya; V. Battista; A. Bay; L. Beaucourt; J. Beddow; F. Bedeschi; I. Bediaga; S. Belogurov; K. Belous; I. Belyaev; E. Ben-Haim; G. Bencivenni; S. Benson; J. Benton; A. Berezhnoy; R. Bernet; M. -O. Bettler; M. van Beuzekom; A. Bien; S. Bifani; T. Bird; A. Bizzeti; P. M. Bjørnstad; T. Blake; F. Blanc; J. Blouw; S. Blusk; V. Bocci; A. Bondar; N. Bondar; W. Bonivento; S. Borghi; A. Borgia; M. Borsato; T. J. V. Bowcock; E. Bowen; C. Bozzi; T. Brambach; J. van den Brand; J. Bressieux; D. Brett; M. Britsch; T. Britton; J. Brodzicka; N. H. Brook; H. Brown; A. Bursche; G. Busetto; J. Buytaert; S. Cadeddu; R. Calabrese; M. Calvi; M. Calvo Gomez; A. Camboni; P. Campana; D. Campora Perez; A. Carbone; G. Carboni; R. Cardinale; A. Cardini; H. Carranza-Mejia; L. Carson; K. Carvalho Akiba; G. Casse; L. Cassina; L. Castillo Garcia; M. Cattaneo; Ch. Cauet; R. Cenci; M. Charles; Ph. Charpentier; S. Chen; S. -F. Cheung; N. Chiapolini; M. Chrzaszcz; K. Ciba; X. Cid Vidal; G. Ciezarek; P. E. L. Clarke; M. Clemencic; H. V. Cliff; J. Closier; V. Coco; J. Cogan; E. Cogneras; P. Collins; A. Comerma-Montells; A. Contu; A. Cook; M. Coombes; S. Coquereau; G. Corti; M. Corvo; I. Counts; B. Couturier; G. A. Cowan; D. C. Craik; M. Cruz Torres; S. Cunliffe; R. Currie; C. D'Ambrosio; J. Dalseno; P. David; P. N. Y. David; A. Davis; K. De Bruyn; S. De Capua; M. De Cian; J. M. De Miranda; L. De Paula; W. De Silva; P. De Simone; D. Decamp; M. Deckenhoff; L. Del Buono; N. Déléage; D. Derkach; O. Deschamps; F. Dettori; A. Di Canto; H. Dijkstra; S. Donleavy; F. Dordei; M. Dorigo; A. Dosil Suárez; D. Dossett; A. Dovbnya; K. Dreimanis; G. Dujany; F. Dupertuis; P. Durante; R. Dzhelyadin; A. Dziurda; A. Dzyuba; S. Easo; U. Egede; V. Egorychev; S. Eidelman; S. Eisenhardt; U. Eitschberger; R. Ekelhof; L. Eklund; I. El Rifai; Ch. Elsasser; S. Ely; S. Esen; H. -M. Evans; T. Evans; A. Falabella; C. Färber; C. Farinelli; N. Farley; S. Farry; RF Fay; D. Ferguson; V. Fernandez Albor; F. Ferreira Rodrigues; M. Ferro-Luzzi; S. Filippov; M. Fiore; M. Fiorini; M. Firlej; C. Fitzpatrick; T. Fiutowski; M. Fontana; F. Fontanelli; R. Forty; O. Francisco; M. Frank; C. Frei; M. Frosini; J. Fu; E. Furfaro; A. Gallas Torreira; D. Galli; S. Gallorini; S. Gambetta; M. Gandelman; P. Gandini; Y. Gao; J. Garofoli; J. Garra Tico; L. Garrido; C. Gaspar; R. Gauld; L. Gavardi; G. Gavrilov; E. Gersabeck; M. Gersabeck; T. Gershon; Ph. Ghez; A. Gianelle; S. Giani'; V. Gibson; L. Giubega; V. V. Gligorov; C. Göbel; D. Golubkov; A. Golutvin; A. Gomes; H. Gordon; C. Gotti; M. Grabalosa Gándara; R. Graciani Diaz; L. A. Granado Cardoso; E. Graugés; G. Graziani; A. Grecu; E. Greening; S. Gregson; P. Griffith; L. Grillo; O. Grünberg; B. Gui; E. Gushchin; Yu. Guz; T. Gys; C. Hadjivasiliou; G. Haefeli; C. Haen; S. C. Haines; S. Hall; B. Hamilton; T. Hampson; X. Han; S. Hansmann-Menzemer; N. Harnew; S. T. Harnew; J. Harrison; T. Hartmann; J. He; T. Head; V. Heijne; K. Hennessy; P. Henrard; L. Henry; J. A. Hernando Morata; E. van Herwijnen; M. Heß; A. Hicheur; D. Hill; M. Hoballah; C. Hombach; W. Hulsbergen; P. Hunt; N. Hussain; D. Hutchcroft; D. Hynds; M. Idzik; P. Ilten; R. Jacobsson; A. Jaeger; J. Jalocha; E. Jans; P. Jaton; A. Jawahery; F. Jing; M. John; D. Johnson; C. R. Jones; C. Joram; B. Jost; N. Jurik; M. Kaballo; S. Kandybei; W. Kanso; M. Karacson; T. M. Karbach; S. Karodia; M. Kelsey; I. R. Kenyon; T. Ketel; B. Khanji; C. Khurewathanakul; S. Klaver; O. Kochebina; M. Kolpin; I. Komarov; R. F. Koopman; P. Koppenburg; M. Korolev; A. Kozlinskiy; L. Kravchuk; K. Kreplin; M. Kreps; G. Krocker; P. Krokovny; F. Kruse; W. Kucewicz; M. Kucharczyk; V. Kudryavtsev; K. Kurek; T. Kvaratskheliya; V. N. La Thi; D. Lacarrere; G. Lafferty; A. Lai; D. Lambert; R. W. Lambert; E. Lanciotti; G. Lanfranchi; C. Langenbruch; B. Langhans; T. Latham; C. Lazzeroni; R. Le Gac; J. van Leerdam; J. -P. Lees; R. Lefèvre; A. Leflat; J. Lefrançois; S. Leo; O. Leroy; T. Lesiak; B. Leverington; Y. Li; M. Liles; R. Lindner; C. Linn; F. Lionetto; B. Liu; G. Liu; S. Lohn; I. Longstaff; J. H. Lopes; N. Lopez-March; P. Lowdon; H. Lu; D. Lucchesi; H. Luo; A. Lupato; E. Luppi; O. Lupton; F. Machefert; I. V. Machikhiliyan; F. Maciuc; O. Maev; S. Malde; G. Manca; G. Mancinelli; J. Maratas; J. F. Marchand; U. Marconi; C. Marin Benito; P. Marino; R. Märki; J. Marks

2014-07-16T23:59:59.000Z

425

Long lifetime, low intensity light source for use in nighttime viewing of equipment maps and other writings  

DOE Patents [OSTI]

A long-lifetime light source with sufficiently low intensity to be used for reading a map or other writing at nighttime, while not obscuring the user's normal night vision is disclosed. This light source includes a diode electrically connected in series with a small power source and a lens properly positioned to focus at least a portion of the light produced by the diode. 1 fig.

Frank, A.M.; Edwards, W.R.

1983-10-11T23:59:59.000Z

426

Long lifetime, low intensity light source for use in nighttime viewing of equipment maps and other writings  

DOE Patents [OSTI]

A long-lifetime light source is discussed with sufficiently low intensity to be used for reading a map or other writing at nightime, while not obscuring the user's normal night vision. This light source includes a diode electrically connected in series with a small power source and a lens properly positioned to focus at least a portion of the light produced by the diode.

Frank, A.M.; Edwards, W.R.

1982-03-23T23:59:59.000Z

427

E-Print Network 3.0 - a-bomb survivors Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

survivors. The reason that the A-bomb... depicts lifetime cancer risks from a given low dose of radiation, based on results from A-bomb survivors... .15 200 mAs different organs...

428

E-Print Network 3.0 - atomic bomb radiation Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

survivors. The reason that the A-bomb... depicts lifetime cancer risks from a given low dose of radiation, based on results from A-bomb survivors... S, Funamoto S, Nishi N, Soda...

429

Colorectal cancer and diet in Scotland   

E-Print Network [OSTI]

Introduction Colorectal cancer is a cancer that forms in the tissues of the colon and/ or rectum and more than 95% of colorectal cancers are adenocarcinomas. It is the third most common cancer in incidence and mortality ...

Theodoratou, Evropi

2008-01-01T23:59:59.000Z

430

Radiation Risk from Chronic Low Dose-Rate Radiation Exposures: The Role of Life-Time Animal Studies - Workshop October 2005  

SciTech Connect (OSTI)

As a part of Radiation research conference, a workshop was held on life-long exposure studies conducted in the course of irradiation experiements done at Argonne National Laboratory between 1952-1992. A recent review article documents many of the issues discussed at that workshop.

Gayle Woloschak

2009-12-16T23:59:59.000Z

431

Risks and Risk Governance in Unconventional Shale Gas Development  

E-Print Network [OSTI]

Risks and Risk Governance in Unconventional Shale Gas Development Mitchell J. Small,*, Paul C, Desert Research Institute, Reno, Nevada 89512, United States 1. INTRODUCTION The recent U.S. shale gas Issue: Understanding the Risks of Unconventional Shale Gas Development Published: July 1, 2014 A broad

Jackson, Robert B.

432

The Post-Shock Chemical Lifetimes of Outflow Tracers and a Possible New Mechanism to Produce Water Ice Mantles  

E-Print Network [OSTI]

We have used a coupled time-dependent chemical and dynamical model to investigate the lifetime of the chemical legacy left in the wake of C-type shocks. We concentrate this study on the chemistry of H2O and O2, two molecules which are predicted to have abundances that are significantly affected in shock-heated gas. Two models are presented: (1) a three-stage model of pre-shock, shocked, and post-shock gas; and (2) a Monte-Carlo cloud simulation where we explore the effects of stochastic shock activity on molecular gas over a cloud lifetime. In agreement with previous studies, we find that shock velocities in excess of 10 km s^-1 are required to convert all of the oxygen not locked in CO into H2O before the gas has an opportunity to cool. For pure gas-phase models the lifetime of the high water abundances, or ``H2O legacy'', in the post-shock gas is 4 - 7 x 10^5 years. Through the Monte Carlo cloud simulation we demonstrate that the time-average abundance of H2O is a sensitive function of the frequency of shoc...

Bergin, E A; Neufeld, D A; Bergin, Edwin A.; Melnick, Gary J.; Neufeld, David A.

1998-01-01T23:59:59.000Z

433

EqualChance: Addressing Intra-set Write Variation to Increase Lifetime of Non-volatile Caches  

SciTech Connect (OSTI)

To address the limitations of SRAM such as high-leakage and low-density, researchers have explored use of non-volatile memory (NVM) devices, such as ReRAM (resistive RAM) and STT-RAM (spin transfer torque RAM) for designing on-chip caches. A crucial limitation of NVMs, however, is that their write endurance is low and the large intra-set write variation introduced by existing cache management policies may further exacerbate this problem, thereby reducing the cache lifetime significantly. We present EqualChance, a technique to increase cache lifetime by reducing intra-set write variation. EqualChance works by periodically changing the physical cache-block location of a write-intensive data item within a set to achieve wear-leveling. Simulations using workloads from SPEC CPU2006 suite and HPC (high-performance computing) field show that EqualChance improves the cache lifetime by 4.29X. Also, its implementation overhead is small, and it incurs very small performance and energy loss.

Mittal, Sparsh [ORNL; Vetter, Jeffrey S [ORNL

2014-01-01T23:59:59.000Z

434

(Energy Risk Professional, ERP), (GARP),  

E-Print Network [OSTI]

1 ( ) : . (Energy Risk Professional, ERP and Chris Strickland. Energy Derivatives: Pricing and Risk Management (London: Lacima Publications, 2000). Chapter 4: Energy Forward Curves ­ Steven Errera and Stewart L. Brown. Fundamentals

Kaplan, Alexander

435

Essays on Measuring Systemic Risk  

E-Print Network [OSTI]

CoRISK indicator, whereas HSBC with the lowest average VaRAG * † Barclays Bank Plc * † HSBC Holdings Plc * † Lloyds

Sharifova, Manizha

2014-01-01T23:59:59.000Z

436

"" EPAT# Risk Assessments Environmental Impact  

E-Print Network [OSTI]

"" EPAT# Risk Assessments Appendixes Environmental Impact Statement NESHAPS for Radionuclides for Hazardous Air Pollutants Risk Assessments Environmental Impact Statement for NESHAPS Radionuclides VOLUME 2 for Hazardous Air Pollutants EPA 520.1'1.-89-006,-2 Risk Assessments Environmental Impact Statement for NESHAPS

437

Risk Management Process Overview | Department of Energy  

Energy Savers [EERE]

risk management process The cybersecurity risk management process explained in the Electricity Sector Cybersecurity Risk Management Process (RMP) Guideline has two primary...

438

Equity Risk Premium and Insecure Property Rights  

E-Print Network [OSTI]

Paper # 2009 -01 Equity Risk and Insecure Property Rightsof California Berkeley Equity Risk Premium and InsecureHow much of the equity risk premium puzzle can be attributed

Magin, Konstantin

2009-01-01T23:59:59.000Z

439

Risk-Averse Stochastic Dual Dynamic Programming  

E-Print Network [OSTI]

Feb 26, 2013 ... Abstract: We formulate a risk-averse multi-stage stochastic program using conditional value at risk as the risk measure. The underlying random ...

Václav Kozmík

2013-02-26T23:59:59.000Z

440

Vulnerability, Risk Management, and Agricultural Development  

E-Print Network [OSTI]

P. (1980). “Attitudes Towards Risk: Experimental MeasurementIncentive Flexibility, and Risk. ” Americal Journal ofCaria, A. S. (2009), Risk Attitudes and The Formation of

Fafchamps, Marcel

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "lifetime cancer risk" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Risk Taking and Gender in Hierarchies  

E-Print Network [OSTI]

and Investors’ Attitudes toward Risk. ” forthcoming (2003)in attitudes toward ?nancial risk. ” Evolution and HumanGrossman. 2005a. “Sex and Risk: Experimen- tal Evidence. ” (

Scotchmer, Suzanne

2006-01-01T23:59:59.000Z

442

NGNP Risk Management Database: A Model for Managing Risk  

SciTech Connect (OSTI)

To facilitate the implementation of the Risk Management Plan, the Next Generation Nuclear Plant (NGNP) Project has developed and employed an analytical software tool called the NGNP Risk Management System (RMS). A relational database developed in Microsoft® Access, the RMS provides conventional database utility including data maintenance, archiving, configuration control, and query ability. Additionally, the tool’s design provides a number of unique capabilities specifically designed to facilitate the development and execution of activities outlined in the Risk Management Plan. Specifically, the RMS provides the capability to establish the risk baseline, document and analyze the risk reduction plan, track the current risk reduction status, organize risks by reference configuration system, subsystem, and component (SSC) and Area, and increase the level of NGNP decision making.

John Collins

2009-09-01T23:59:59.000Z

443

Cell Senescence: Aging and Cancer  

ScienceCinema (OSTI)

Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

Campisi, Judith

2013-05-29T23:59:59.000Z

444

Spontaneous Fission Modes and Lifetimes of Superheavy Elements in the Nuclear Density Functional Theory  

SciTech Connect (OSTI)

Background: The reactions with the neutron-rich 48Ca beam and actinide targets resulted in the detection of new superheavy (SH) nuclides with Z=104 118. The unambiguous identification of the new isotopes, however, still poses a problem because their -decay chains terminate by spontaneous fission (SF) before reaching the known region of the nuclear chart. The understanding of the competition between -decay and SF channels in SH nuclei is, therefore, of crucial importance for our ability to map the SH region and to assess its extent.

Purpose: We perform self-consistent calculations of the competing decay modes of even-even SH isotopes with 108 Z 126 and 148 N 188.

Methods: We use the state-of-the-art computational framework based on self-consistent symmetry-unrestricted nuclear density functional theory capable of describing the competition between nuclear attraction and electrostatic repulsion. We apply the SkM* Skyrme energy density functional. The collective mass tensor of the fissioning superfluid nucleus is computed by means of the cranking approximation to the adiabatic time-dependent Hartree-Fock-Bogoliubov (HFB) approach. This paper constitutes a systematic self-consistent study of spontaneous fission in the SH region, carried out at a full HFB level, that simultaneously takes into account both triaxiality and reflection asymmetry.

Results: Breaking axial symmetry and parity turns out to be crucial for a realistic estimate of collective action; it results in lowering SF lifetimes by more than 7 orders of magnitude in some cases. We predict two competing SF modes: reflection symmetric modes and reflection asymmetric modes.

Conclusions: The shortest-lived SH isotopes decay by SF; they are expected to lie in a narrow corridor formed by 280Hs, 284Fl, and 118284Uuo that separates the regions of SH nuclei synthesized in cold-fusion and hot-fusion reactions. The region of long-lived SH nuclei is expected to be centered on 294Ds with a total half-life of 1.5 days. Our survey provides a solid benchmark for the future improvements of self-consistent SF calculations in the region of SH nuclei.

Staszczak, A, [UTK/ORNL/Inst. Physics, Maria Curie-Sklodowska University, Poland; Baran, A. [UTK/ORNL/Inst. Physics, Maria Curie-Sklodowska University, Poland; Nazarewicz, Witold [UTK/ORNL/University of Warsaw

2013-01-01T23:59:59.000Z

445

Quantum efficiency temporal response and lifetime of a GaAs cathode in SRF electron gun  

SciTech Connect (OSTI)

RF electron guns with a strained super lattice GaAs cathode can generate polarized electron beam of higher brightness and lower emittance than do DC guns, due to their higher field gradient at the cathode's surface. In a normal conducting RF gun, the extremely high vaccum required by these cathodes can not be met. We report on an experiment with a superconducting SRF gun, which can maintain a vacuum of nearly 10-12 torr because of cryo-pumping at the temperature of 4.2K. With conventional activation, we obtained a QE of 3% at 532 nm, with lifetime of nearly 3 days in the preparation chamber. We plan to use this cathode in a 1.3 GHz 1/2 cell SRF gun to study its performance. In addition, we studied the multipacting at the location of cathode. A new model based on the Forkker-Planck equation which can estimate the bunch length of the electron beam is discussed in this paper. Future particle accelerators such as eRHIC and ILC require high brightness, high current polarized electrons Recently, using a superlattice crystal, the maximum polarization of 95% was reached. Activation with Cs,O lowers the electron affinity and makes it energetically possible for all the electrons excited in to the conduction band and reach the surface to escape into the vacuum. Presently the polarized electron sources are based on DC gun, such as that at the CEBAF at Jlab. In these devices, the life time of the cathode is extended due to the reduced back bombardment in their UHV conditions. However, the low accelerating gradient of the DC guns lead to poor longitudinal emittance. The higher accelerating gradient of the RF gun generates low emittance beams. Superconducting RF guns combine the excellent vacuum conditions of the DC guns with the higher accelerating gradients of the RF guns and provide potentially a long lived cathode with very low transverse and longitudinal emittance. In our work at BNL, we successfully activated the GaAs. The quantum efficient is 3% at 532 nm and is expected to improve further. In addition, we studied the multipacting at the location of cathode. A new model based on the Forkker-Planck equation which can estimate the bunch length of the electron beam is discussed in this paper.

Wang, E.; Ben-Zvi, I.; Kewisch, J.; Burrill, A.; Rao, T.; Wu, Q.; Holmes, D.

2010-05-23T23:59:59.000Z

446

Hindawi Publishing Corporation Prostate Cancer  

E-Print Network [OSTI]

Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 176164, 7 pages doi:10.1155/2011/176164 Clinical Study Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone

Ahn, Hongshik

447

Optimal risk sharing under distorted probabilities  

E-Print Network [OSTI]

theory of risk. Geneva Pap. Risk Insurance Theory 25, 141–A. : Two-persons ef?cient risk-sharing and equilibria for36(2), 189–223 (2008) Optimal risk sharing under distorted

Ludkovski, Michael; Young, Virginia R.

2009-01-01T23:59:59.000Z

448

Methodology of organizational learning in risk management A method of organizational risk perception by the stakeholders  

E-Print Network [OSTI]

Methodology of organizational learning in risk management A method of organizational risk) and the Departmental Veterinary Services (DDSV) within the framework of organizational learning in risk management Experience reflection, organizational risks, food-related sanitary alert, risk perception. Abstract

Paris-Sud XI, Université de

449

Photovoltaic Degradation Risk: Preprint  

SciTech Connect (OSTI)

The ability to accurately predict power delivery over the course of time is of vital importance to the growth of the photovoltaic (PV) industry. Important cost drivers include the efficiency with which sunlight is converted into power, how this relationship changes over time, and the uncertainty in this prediction. An accurate quantification of power decline over time, also known as degradation rate, is essential to all stakeholders - utility companies, integrators, investors, and researchers alike. In this paper we use a statistical approach based on historical data to quantify degradation rates, discern trends and quantify risks related to measurement uncertainties, number of measurements and methodologies.

Jordan, D. C.; Kurtz, S. R.

2012-04-01T23:59:59.000Z

450

Risk Identification and Assessment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared0 Resource Program September DepartmentRio GrandeAssessmentRisk

451

Technology: basis, gaps, risks and facility needs.  

E-Print Network [OSTI]

" lifetime dose =12-50 dpa ( M. Abdou's talk) FS irradiation data base from fission reactors extends to ~80 up to ~ 300 appm He at irrad. temp. > 350°C. (M.Abdou's) RAFM is the ref. structural material

452