National Library of Energy BETA

Sample records for lifetime cancer risk

  1. Identifying Risk Groups Associated with Colorectal Cancer

    E-Print Network [OSTI]

    Jin, Huidong "Warren"

    Identifying Risk Groups Associated with Colorectal Cancer Jie Chen1 , Hongxing He1 , Huidong Jin1 of identifying and describing risk groups for colorectal cancer (CRC) from population based administrative health are applied to the colorectal cancer patients' profiles in contrast to background pa- tients' profiles

  2. LITERATURE REVIEW Autism and Cancer Risk

    E-Print Network [OSTI]

    Crespi, Bernard J.

    LITERATURE REVIEW Autism and Cancer Risk B. Crespi A literature review was conducted on the genetic and developmental bases of autism in relation to genes and pathways associated with cancer risk. Convergent lines cancer-associated genes and pathways, and (4) contrasts with schizophrenia, Parkinson's, and Alzheimer

  3. Bacon butty cancer risk ONLINE REPORTER

    E-Print Network [OSTI]

    Lega, Joceline

    Bacon butty cancer risk ONLINE REPORTER Published: 31st October 2007 0 PROCESSED meats, including ham and bacon are such a high risk factor for bowel cancer they should be avoided completely, bacon, pastrami, salami, and frankfurters. However, not all minced meats and hamburgers were considered

  4. Serum 25-hydroxyvitamin D and risk of breast cancer

    E-Print Network [OSTI]

    Mohr, Sharif Burgette

    2012-01-01

    and prevention of breast cancer: pooled analysis. Anticancerand reduced risk of breast cancer: a population-based case-between vitamin D and breast cancer incidence and natural

  5. Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk

    E-Print Network [OSTI]

    2009-01-01

    1996. Cigarette smoking and breast cancer. Cancer Epidemiol.Cigarette smoking and breast cancer. BMJ 310, 1431-1433.smoking, and the risk of breast cancer. Cancer Detect. Prev.

  6. Targeted CT Screening for Lung Cancer using Absolute Risk Prediction

    E-Print Network [OSTI]

    Brent, Roger

    Targeted CT Screening for Lung Cancer using Absolute Risk Prediction Stephanie A. Kovalchik skovalch@rand.org FHCRC 2014 Risk Prediction Symposium June 11, 2014 1 #12;Outline · Lung Cancer Epidemiology and Screening · Screening Benefit and Absolute Risk · Absolute Risk Model for Lung Cancer

  7. EPA 402-R-93-076 ESTIMATING RADIOGENIC CANCER RISKS

    E-Print Network [OSTI]

    comparing health risk estimates due to low level exposures of low-LET radiation based on models recently This document presents a revised methodology for EPA's estimation of cancer risks due to low-LET radiation. With the exception of breast cancer, low-LET radiogenic cancer risks are assumed to be reduced by a dose and dose

  8. The Reproductive Factors Linked to Breast Cancer Risk

    E-Print Network [OSTI]

    Chen, Tsuhan

    The Reproductive Factors Linked to Breast Cancer Risk The breast is a reproductive organ, so it makes sense that breast cancer risk would be related to reproductive variables. A woman's own estrogen contributes to the normal development and functioning of the breast, as well as to breast cancer risk. Being

  9. SU-E-T-208: Incidence Cancer Risk From the Radiation Treatment for Acoustic Neuroma Patient

    SciTech Connect (OSTI)

    Kim, D; Chung, W; Shin, D; Yoon, M

    2014-06-01

    Purpose: The present study aimed to compare the incidence risk of a secondary cancer from therapeutic doses in patients receiving intensitymodulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic radiosurgery (SRS). Methods: Four acoustic neuroma patients were treated with IMRT, VMAT, or SRS. Their incidnece excess relative risk (ERR), excess absolute risk (EAR), and lifetime attributable risk (LAR) were estimated using the corresponding therapeutic doses measured at various organs by radio-photoluminescence glass dosimeters (RPLGD) placed inside a humanoid phantom. Results: When a prescription dose was delivered in the planning target volume of the 4 patients, the average organ equivalent doses (OED) at the thyroid, lung, normal liver, colon, bladder, prostate (or ovary), and rectum were measured. The OED decreased as the distance from the primary beam increased. The thyroid received the highest OED compared to other organs. A LAR were estimated that more than 0.03% of AN patients would get radiation-induced cancer. Conclusion: The tyroid was highest radiation-induced cancer risk after radiation treatment for AN. We found that LAR can be increased by the transmitted dose from the primary beam. No modality-specific difference in radiation-induced cancer risk was observed in our study.

  10. Buccal Spectral Markers for Lung Cancer Risk Stratification

    E-Print Network [OSTI]

    Hartline, Jason D.

    Buccal Spectral Markers for Lung Cancer Risk Stratification Andrew J. Radosevich1 *, Nikhil N, United States of America Abstract Lung cancer remains the leading cause of cancer deaths in the US with .150,000 deaths per year. In order to more effectively reduce lung cancer mortality, more sophisticated

  11. Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

    SciTech Connect (OSTI)

    Boukheris, Houda; Stovall, Marilyn; Gilbert, Ethel S.; Stratton, Kayla L.; Smith, Susan A.; Weathers, Rita; Hammond, Sue; Mertens, Ann C.; Donaldson, Sarah S.; Armstrong, Gregory T.; Robison, Leslie L.; Neglia, Joseph P.; Inskip, Peter D.

    2013-03-01

    Purpose: To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials: Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results: During the time period of the study, 23 cases of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion: Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies.

  12. Estrogen withdrawal, increased breast cancer risk and the KRAS-variant

    E-Print Network [OSTI]

    2015-01-01

    estrogen signaling and Table 5. Second breast cancer risk inKRAS- variant breast cancer patients controlling for lobularand metachronous breast cancer when controlling for lobular

  13. Cancer risk estimates from radiation therapy for heterotopic ossification prophylaxis after total hip arthroplasty

    SciTech Connect (OSTI)

    Mazonakis, Michalis; Berris, Theoharris; Damilakis, John; Lyraraki, Efrossyni

    2013-10-15

    Purpose: Heterotopic ossification (HO) is a frequent complication following total hip arthroplasty. This study was conducted to calculate the radiation dose to organs-at-risk and estimate the probability of cancer induction from radiotherapy for HO prophylaxis.Methods: Hip irradiation for HO with a 6 MV photon beam was simulated with the aid of a Monte Carlo model. A realistic humanoid phantom representing an average adult patient was implemented in Monte Carlo environment for dosimetric calculations. The average out-of-field radiation dose to stomach, liver, lung, prostate, bladder, thyroid, breast, uterus, and ovary was calculated. The organ-equivalent-dose to colon, that was partly included within the treatment field, was also determined. Organ dose calculations were carried out using three different field sizes. The dependence of organ doses upon the block insertion into primary beam for shielding colon and prosthesis was investigated. The lifetime attributable risk for cancer development was estimated using organ, age, and gender-specific risk coefficients.Results: For a typical target dose of 7 Gy, organ doses varied from 1.0 to 741.1 mGy by the field dimensions and organ location relative to the field edge. Blocked field irradiations resulted in a dose range of 1.4–146.3 mGy. The most probable detriment from open field treatment of male patients was colon cancer with a high risk of 564.3 × 10{sup ?5} to 837.4 × 10{sup ?5} depending upon the organ dose magnitude and the patient's age. The corresponding colon cancer risk for female patients was (372.2–541.0) × 10{sup ?5}. The probability of bladder cancer development was more than 113.7 × 10{sup ?5} and 110.3 × 10{sup ?5} for males and females, respectively. The cancer risk range to other individual organs was reduced to (0.003–68.5) × 10{sup ?5}.Conclusions: The risk for cancer induction from radiation therapy for HO prophylaxis after total hip arthroplasty varies considerably by the treatment parameters, organ site in respect to treatment volume and patient's gender and age. The presented risk estimates may be useful in the follow-up studies of irradiated patients.

  14. Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

    E-Print Network [OSTI]

    Amin Al Olama, Ali; Benlloch, Sara; Antoniou, Antonis C.; Giles, Graham G.; Severi, Gianluca; Neal, David; Hamdy, Freddie C.; Donovan, Jenny L.; Muir, Kenneth; Schleutker, Johanna; Henderson, Brian E.; Haiman, Christopher; Schumacher, Fredrick R.; Pashayan, Nora; Pharoah, Paul D. P.; Ostrander, Elaine A.; Stanford, Janet L.; Batra, Jyotsna; Clements, Judith A.; Chambers, Suzanne K.; Weischer, Maren; Nordestgaard, Břrge G.; Ingles, Sue Ann; Sorensen, Karina D.; Orntoft, Torben F.; Park, Jong Y.; Cybulski, Cezary; Maier, Christiane; Doerk, Thilo; Dickinson, Joanne L.; Cannon-Albright, Lisa; Brenner, Hermann; Rebbeck, Timothy R.; Zeigler-Johnson, Charnita; Habuchi, Tomonori; Thibodeau, Stephen N.; Cooney, Kathleen; Chappuis, Pierre O.; Hutter, Pierre; Kaneva, Radka P.; Foulkes, William D.; Zeegers, Maurice P.; Lu, Yong-Jie; Zhang, Hong-Wei; Stephenson, Robert; Cox, Angela; Southey, Melissa C.; Spurdle, Amanda B.; FitzGerald, Liesel; Leongamornlert, Daniel; Saunders, Edward; Tymrakiewicz, Malgorzata; Guy, Michelle; Dadaev, Tokhir; Little, Sarah J.; Govindasami, Koveela; Sawyer, Emma; Wilkinson, Rosemary; Herkommer, Kathleen; Hopper, John L.; Lophatonanon, Aritaya; Rinckleb, Antje E.; Kote-Jarai, Zsofia; Eeles, Rosalind A.; Easton, Douglas F.

    2015-04-02

    & Prevention.pdf.txt Content-Type text/plain; charset=UTF-8 1 Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci Ali Amin Al Olama1,56, Sara Benlloch1,56, Antonis C... @medschl.cam.ac.uk Tel: 0044 1223 748638 Fax: 0044 1223 748628 Running Title: Risk Analysis of Prostate Cancer in PRACTICAL Consortium Keywords: Prostate Cancer risk, Genetic and Molecular Epidemiology, Genitourinary Cancers: Prostate, Risk...

  15. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The selenium and vitamin E cancer prevention trial (SELECT)

    E-Print Network [OSTI]

    2009-01-01

    PR, Albanes D. Selenium, vitamin E, and prostate cancer--Effect of Selenium and Vitamin E on Risk of Prostate CancerOther Cancers: The Selenium and Vitamin E Cancer Prevention

  16. Second cancer incidence risk estimates using BEIR VII models for standard and complex external beam radiotherapy for early breast cancer

    SciTech Connect (OSTI)

    Donovan, E. M.; James, H.; Bonora, M.; Yarnold, J. R.; Evans, P. M.

    2012-10-15

    Purpose: To compare organ specific cancer incidence risks for standard and complex external beam radiotherapy (including cone beam CT verification) following breast conservation surgery for early breast cancer.Method: Doses from breast radiotherapy and kilovoltage cone beam CT (CBCT) exposures were obtained from thermoluminescent dosimeter measurements in an anthropomorphic phantom in which the positions of radiosensitive organs were delineated. Five treatment deliveries were investigated: (i) conventional tangential field whole breast radiotherapy (WBRT), (ii) noncoplanar conformal delivery applicable to accelerated partial beast irradiation (APBI), (iii) two-volume simultaneous integrated boost (SIB) treatment, (iv) forward planned three-volume SIB, and (v) inverse-planned three volume SIB. Conformal and intensity modulated radiotherapy methods were used to plan the complex treatments. Techniques spanned the range from simple methods appropriate for patient cohorts with a low cancer recurrence risk to complex plans relevant to cohorts with high recurrence risk. Delineated organs at risk included brain, salivary glands, thyroid, contralateral breast, left and right lung, esophagus, stomach, liver, colon, and bladder. Biological Effects of Ionizing Radiation (BEIR) VII cancer incidence models were applied to the measured mean organ doses to determine lifetime attributable risk (LAR) for ages at exposure from 35 to 80 yr according to radiotherapy techniques, and included dose from the CBCT imaging. Results: All LAR decreased with age at exposure and were lowest for brain, thyroid, liver, and bladder (<0.1%). There was little dependence of LAR on radiotherapy technique for these organs and for colon and stomach. LAR values for the lungs for the three SIB techniques were two to three times those from WBRT and APBI. Uncertainties in the LAR models outweigh any differences in lung LAR between the SIB methods. Constraints in the planning of the SIB methods ensured that contralateral breast doses and LAR were comparable to WBRT, despite their added complexity. The smaller irradiated volume of the ABPI plan contributed to a halving of LAR for contralateral breast compared with the other plan types. Daily image guided radiotherapy (IGRT) for a left breast protocol using kilovoltage CBCT contributed <10% to LAR for the majority of organs, and did not exceed 22% of total organ dose. Conclusions: Phantom measurements and calculations of LAR from the BEIR VII models predict that complex breast radiotherapy techniques do not increase the theoretical risk of second cancer incidence for organs distant from the treated breast, or the contralateral breast where appropriate plan constraints are applied. Complex SIB treatments are predicted to increase the risk of second cancer incidence in the lungs compared to standard whole breast radiotherapy; this is outweighed by the threefold reduction in 5 yr local recurrence risk for patients of high risk of recurrence, and young age, from the use of radiotherapy. APBI may have a favorable impact on risk of second cancer in the contralateral breast and lung for older patients at low risk of recurrence. Intensive use of IGRTincreased the estimated values of LAR but these are dominated by the effect of the dose from the radiotherapy, and any increase in LAR from IGRT is much lower than the models' uncertainties.

  17. Vitamin E and the risk of prostate cancer: Updated results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

    E-Print Network [OSTI]

    2012-01-01

    10.1001/jama.2011.1437. Vitamin E and the Risk of Prostateof The Selenium and Vitamin E Cancer Prevention Trial (Effect of Selenium and Vitamin E on Risk of Prostate Cancer

  18. Fluorescence Lifetime Imaging Microscopy (FLIM) System for Imaging of Oral Cancer and Precancer 

    E-Print Network [OSTI]

    Cheng, Shuna

    2014-10-10

    of the requirements for the degree of DOCTOR OF PHILOSOPHY Chair of Committee, Javier A. Jo Co-Chair of Commettee, Kristen C. Maitland Committee Members, Brian E. Applegate Jim Ji Head of Department, Gerard L. Coté December 2014 Major Subject... of multispectral FLIM for oral cancer and precancer detection. iv DEDICATION To my parents and my husband v ACKNOWLEDGEMENTS I want to first thank my advisor Dr. Javier Jo, who has given me the chance to study and work in such a good...

  19. Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility â??Hot-Spotâ?ť

    E-Print Network [OSTI]

    2010-01-01

    and susceptibility to serous ovarian cancer in three studygenetic risk associations for ovarian cancer throughthe international Ovarian Cancer Association Consortium. Br

  20. Radiation Dose and Subsequent Risk for Stomach Cancer in Long-term Survivors of Cervical Cancer

    SciTech Connect (OSTI)

    Kleinerman, Ruth A.; Smith, Susan A.; Holowaty, Eric; Hall, Per; Pukkala, Eero; Vaalavirta, Leila; Stovall, Marilyn; Weathers, Rita; Gilbert, Ethel; Aleman, Berthe M.P.; Kaijser, Magnus; Andersson, Michael; Storm, Hans; Joensuu, Heikki; Lynch, Charles F.; and others

    2013-08-01

    Purpose: To assess the dose–response relationship for stomach cancer after radiation therapy for cervical cancer. Methods and Materials: We conducted a nested, matched case–control study of 201 cases and 378 controls among 53,547 5-year survivors of cervical cancer diagnosed from 1943 to 1995, from 5 international, population-based cancer registries. We estimated individual radiation doses to the site of the stomach cancer for all cases and to corresponding sites for the matched controls (overall mean stomach tumor dose, 2.56 Gy, range 0.03-46.1 and after parallel opposed pelvic fields, 1.63 Gy, range 0.12-6.3). Results: More than 90% of women received radiation therapy, mostly with external beam therapy in combination with brachytherapy. Stomach cancer risk was nonsignificantly increased (odds ratio 1.27-2.28) for women receiving between 0.5 and 4.9 Gy to the stomach cancer site and significantly increased at doses ?5 Gy (odds ratio 4.20, 95% confidence interval 1.41-13.4, P{sub trend}=.047) compared with nonirradiated women. A highly significant radiation dose–response relationship was evident when analyses were restricted to the 131 cases (251 controls) whose stomach cancer was located in the middle and lower portions of the stomach (P{sub trend}=.003), whereas there was no indication of increasing risk with increasing dose for 30 cases (57 controls) whose cancer was located in the upper stomach (P{sub trend}=.23). Conclusions: Our findings show for the first time a significant linear dose–response relationship for risk of stomach cancer in long-term survivors of cervical cancer.

  1. Approaches to cancer assessment in EPA's Integrated Risk Information System

    SciTech Connect (OSTI)

    Gehlhaus, Martin W.; Gift, Jeffrey S.; Hogan, Karen A.; Kopylev, Leonid; Schlosser, Paul M.; Kadry, Abdel-Razak

    2011-07-15

    The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) Program develops assessments of health effects that may result from chronic exposure to chemicals in the environment. The IRIS database contains more than 540 assessments. When supported by available data, IRIS assessments provide quantitative analyses of carcinogenic effects. Since publication of EPA's 2005 Guidelines for Carcinogen Risk Assessment, IRIS cancer assessments have implemented new approaches recommended in these guidelines and expanded the use of complex scientific methods to perform quantitative dose-response assessments. Two case studies of the application of the mode of action framework from the 2005 Cancer Guidelines are presented in this paper. The first is a case study of 1,2,3-trichloropropane, as an example of a chemical with a mutagenic mode of carcinogenic action thus warranting the application of age-dependent adjustment factors for early-life exposure; the second is a case study of ethylene glycol monobutyl ether, as an example of a chemical with a carcinogenic action consistent with a nonlinear extrapolation approach. The use of physiologically based pharmacokinetic (PBPK) modeling to quantify interindividual variability and account for human parameter uncertainty as part of a quantitative cancer assessment is illustrated using a case study involving probabilistic PBPK modeling for dichloromethane. We also discuss statistical issues in assessing trends and model fit for tumor dose-response data, analysis of the combined risk from multiple types of tumors, and application of life-table methods for using human data to derive cancer risk estimates. These issues reflect the complexity and challenges faced in assessing the carcinogenic risks from exposure to environmental chemicals, and provide a view of the current trends in IRIS carcinogenicity risk assessment.

  2. Low Dose Radiation Cancer Risks: Epidemiological and Toxicological Models

    SciTech Connect (OSTI)

    David G. Hoel, PhD

    2012-04-19

    The basic purpose of this one year research grant was to extend the two stage clonal expansion model (TSCE) of carcinogenesis to exposures other than the usual single acute exposure. The two-stage clonal expansion model of carcinogenesis incorporates the biological process of carcinogenesis, which involves two mutations and the clonal proliferation of the intermediate cells, in a stochastic, mathematical way. The current TSCE model serves a general purpose of acute exposure models but requires numerical computation of both the survival and hazard functions. The primary objective of this research project was to develop the analytical expressions for the survival function and the hazard function of the occurrence of the first cancer cell for acute, continuous and multiple exposure cases within the framework of the piece-wise constant parameter two-stage clonal expansion model of carcinogenesis. For acute exposure and multiple exposures of acute series, it is either only allowed to have the first mutation rate vary with the dose, or to have all the parameters be dose dependent; for multiple exposures of continuous exposures, all the parameters are allowed to vary with the dose. With these analytical functions, it becomes easy to evaluate the risks of cancer and allows one to deal with the various exposure patterns in cancer risk assessment. A second objective was to apply the TSCE model with varing continuous exposures from the cancer studies of inhaled plutonium in beagle dogs. Using step functions to estimate the retention functions of the pulmonary exposure of plutonium the multiple exposure versions of the TSCE model was to be used to estimate the beagle dog lung cancer risks. The mathematical equations of the multiple exposure versions of the TSCE model were developed. A draft manuscript which is attached provides the results of this mathematical work. The application work using the beagle dog data from plutonium exposure has not been completed due to the fact that the research project did not continue beyond its first year.

  3. Primary research Polymorphic repeat in AIB1 does not alter breast cancer risk

    E-Print Network [OSTI]

    Brown, Myles

    Primary research Polymorphic repeat in AIB1 does not alter breast cancer risk Christopher A Haiman assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case no association between AIB1 genotype and breast cancer incidence, or specific tumor characteristics

  4. Cancer Risk Assessment: Should New Science be Applied? Workgroup summary

    SciTech Connect (OSTI)

    Richard J. Bull; Antone L. Brooks

    2002-12-15

    OAK-B135 A symposium discussing the implications of certain phenomena observed in radiation biology for cancer risk assessment in general. In July of 2002 a workshop was convened that explored some of the intercellular phenomena that appear to condition responses to carcinogen exposure. Effects that result from communication between cells that appear to either increase the sphere of damage or to modify the sensitivity of cells to further damage were of particular interest. Much of the discussion focused on the effects of ionizing radiation that were transmitted from cells directly hit to cells not receiving direct exposure to radiation (bystander cells). In cell culture, increased rates of mutation, chromosomal aberration, apoptosis, genomic instability, and decreased clonogenic survival have all been observed in cells that have experienced no direct radiation. In addition, there is evidence that low doses of radiation or certain chemicals give rise to adaptive responses in which the treated cells develop resistance to the effects of high doses given in subsequent exposures. Data were presented at the workshop indicating that low dose exposure of animals to radiation and some chemicals frequently reduces the spontaneous rate of mutation in vitro and tumor responses in vivo. Finally, it was concluded that considerable improvement in understanding of how genetic variation may modify the impact of these phenomena is necessary before the risk implications can be fully appreciated. The workshop participants discussed the substantive challenge that these data present with respect to simple linear methodologies that are currently used in cancer risk assessment and attempted to identify broad strategies by which these phenomena may start to be used to refine cancer risk assessment methods in the future.

  5. TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors

    E-Print Network [OSTI]

    TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk mutations are observed in about 40e70% of lung cancer tissues, and the hot spot codon mu- tations factors that influence TP53 gene mutation in lung cancer patients residing areas with high lung cancer

  6. Clinical Investigation: Breast Cancer Predicting the Risk of Secondary Lung Malignancies

    E-Print Network [OSTI]

    Brenner, David Jonathan

    Clinical Investigation: Breast Cancer Predicting the Risk of Secondary Lung Malignancies Associated. Accepted for publication Sep 19, 2011 Summary The risk of secondary lung cancers after whole breast lower risk of secondary lung malignancy than treatment with the supine breast tech- nique. Breast

  7. Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

    E-Print Network [OSTI]

    Mavaddat, Nasim; Pharoah, Paul D. P.; Michailidou, Kyriaki; Tyrer, Jonathan; Brook, Mark N.; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Dunning, Alison M.; Shah, Mitul; Luben, Robert; Brown, Judith; Bojesen, Stig E.; Nordestgaard, Břrge G.; Nielsen, Sune F.; Flyger, Henrik; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Peto, Julian; dos-Santos-Silva, Isabel; Dudbridge, Frank; Johnson, Nichola; Schmidt, Marjanka K.; Broeks, Annegien; Verhoef, Senno; Rutgers, Emiel J.; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Schoemaker, Minouk J.; Figueroa, Jonine; Chanock, Stephen J.; Brinton, Louise; Lissowska, Jolanta; Couch, Fergus J.; Olson, Janet E.; Vachon, Celine; Pankratz, Vernon S.; Lambrechts, Diether; Wildiers, Hans; Van Ongeval, Chantal; van Limbergen, Erik; Kristensen, Vessela; Grenaker Alnćs, Grethe; Nord, Silje; Borresen-Dale, Anne-Lise; Nevanlinna, Heli; Muranen, Taru A.; Aittomäki, Kristiina; Blomqvist, Carl; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Fasching, Peter A.; Haeberle, Lothar; Ekici, Arif B.; Beckmann, Matthias W.; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Trentham-Dietz, Amy; Newcomb, Polly; Titus, Linda; Egan, Kathleen M.; Hunter, David J.; Lindstrom, Sara; Tamimi, Rulla M.; Kraft, Peter; Rahman, Nazneen; Turnbull, Clare; Renwick, Anthony; Seal, Sheila; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Benitez, Javier; Pilar Zamora, M.; Arias Perez, Jose Ignacio; Menéndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Bogdanova, Natalia V.; Antonenkova, Natalia N.; Dörk, Thilo; Anton-Culver, Hoda; Neuhausen, Susan L.; Ziogas, Argyrios; Bernstein, Leslie; Devilee, Peter; Tollenaar, Robert A. E. M.; Seynaeve, Caroline; van Asperen, Christi J.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Khusnutdinova, Elza; Bermisheva, Marina; Prokofyeva, Darya; Takhirova, Zalina; Meindl, Alfons; Schmutzler, Rita K.; Sutter, Christian; Yang, Rongxi; Schürmann, Peter; Bremer, Michael; Christiansen, Hans; Park-Simon, Tjoung-Won; Hillemanns, Peter; Guénel, Pascal; Truong, Thérčse; Menegaux, Florence; Sanchez, Marie; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Pensotti, Valeria; Hopper, John L.; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C.; Brauch, Hiltrud; Brüning, Thomas; Ko, Yon-Dschun; Sigurdson, Alice J.; Doody, Michele M.; Hamann, Ute; Torres, Diana; Ulmer, Hans-Ulrich; Försti, Asta; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Marie Mulligan, Anna; Chenevix-Trench, Georgia; Balleine, Rosemary; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Lindblom, Annika; Margolin, Sara; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Eilber, Ursula; Wang-Gohrke, Shan; Hooning, Maartje J.; Hollestelle, Antoinette; van den Ouweland, Ans M. W.; Koppert, Linetta B.; Carpenter, Jane; Clarke, Christine; Scott, Rodney; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Brenner, Hermann; Arndt, Volker; Stegmaier, Christa; Karina Dieffenbach, Aida; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Offit, Kenneth; Vijai, Joseph; Robson, Mark; Rau-Murthy, Rohini; Dwek, Miriam; Swann, Ruth; Annie Perkins, Katherine; Goldberg, Mark S.; Labrčche, France; Dumont, Martine; Eccles, Diana M.; Tapper, William J.; Rafiq, Sajjad; John, Esther M.; Whittemore, Alice S.; Slager, Susan; Yannoukakos, Drakoulis; Toland, Amanda E.; Yao, Song; Zheng, Wei; Halverson, Sandra L.; González-Neira, Anna; Pita, Guillermo; Rosario Alonso, M.; Álvarez, Nuria; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Baynes, Caroline; Ahmed, Shahana; Maranian, Mel; Healey, Catherine S.; Simard, Jacques; Hall, Per; Easton, Douglas F.; Garcia-Closas, Montserrat

    2015-04-02

    Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical...

  8. Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men

    E-Print Network [OSTI]

    2010-01-01

    y ORIGINAL PAPER Serum 25-OH vitamin D levels and risk ofshown clear evidence of vitamin D’s anti-tumor effects onthe associa- tion between vitamin D and prostate cancer risk

  9. Serum 25-hydroxyvitamin D and risk of breast cancer

    E-Print Network [OSTI]

    Mohr, Sharif Burgette

    2012-01-01

    and prevention of breast cancer: pooled analysis. AnticancerBray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA-Cancer J Clin. 2005;55(2):74-108. American Cancer

  10. Vol. 00 no. 00 2008 A New Challenge for Text Mining: Cancer Risk

    E-Print Network [OSTI]

    Korhonen, Anna

    Vol. 00 no. 00 2008 Pages 1­4 A New Challenge for Text Mining: Cancer Risk Assessment Ian Lewin 1 Institutet, S-17177, Stockholm, Sweden ABSTRACT Motivation: Cancer Risk Assessment (RA) of chemicals are now installing the automated classifier into the pipeline so that we can assess its impact on the RA

  11. Regulatory approval of cancer risk-reducing (chemopreventive) drugs: moving what we have learned into the clinic.

    E-Print Network [OSTI]

    2011-01-01

    Risk-Reducing (Chemopreventive) Drugs: Moving What We Haverisk reduction) drugs and discusses possible improvements toof Cancer Risk- Reducing Drugs approach along with primary

  12. Lung cancer risks in the vicinity of uranium tailings sites. [UMTRA Project

    SciTech Connect (OSTI)

    Rogers, V.C.; Sandquist, G.M. (Rogers and Associates Engineering Corp., Salt Lake City, UT (USA))

    1982-04-01

    Lung cancer mortality data have been assembled for many counties of interest to the Uranium Mill Tailings Remedial Action Program (UMTRAP). The counties generally either contain UMTRAP tailings sites or are adjacent to them. The lung cancer rates of nearly all counties are less than the US average rate. In addition, some of the many factors associated with lung cancer are identified as are cancer risk estimators for radon daughters. 17 refs., 19 figs., 1 tab.

  13. A Pilot study of the Sharing Risk Information Tool (ShaRIT) for Families with Hereditary Breast and Ovarian Cancer Syndrome

    E-Print Network [OSTI]

    Kardashian, Ani; Fehniger, Julia; Creasman, Jennifer; Cheung, Eleanor; Beattie, Mary

    2012-01-01

    Hereditary Breast and Ovarian Cancer Syndrome. Hereditaryrisks of breast and ovarian cancer associated with BRCA1 orMandell JB: Breast and ovarian cancer risks due to inherited

  14. Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk

    E-Print Network [OSTI]

    2009-01-01

    Group on the Evaluation of Carcinogenic Risk to Humans.on the Evaluation of Carcinogenic Risks to Humans. Volumeon the Evaluation of Carcinogenic Risks to Humans, Volume

  15. Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know

    E-Print Network [OSTI]

    Brenner, David Jonathan

    Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know David J low radiation doses the situation is much less clear, but the risks of low-dose radiation terrorism. We review the difficulties involved in quantifying the risks of low-dose radiation and address

  16. Using mammographic density to predict breast cancer risk: dense area or percent dense area

    E-Print Network [OSTI]

    Stone, Jennifer; Ding, Jane; Warren, Ruth M L; Duffy, Stephen; Hopper, John L

    2010-11-18

    and dense area were strongly associated with breast cancer risk; however, inclusion of dense area in a PDA-adjusted model improved the pre- diction of breast cancer risk, but not vice versa. This suggests that, in terms of a single parameter, dense area... dense area alone. Conclusions: As a single parameter, dense area provides more information than PDA on breast cancer risk. Introduction A number of prospective, nested case control studies have shown that, for women of the same age, those with greater...

  17. Two-Year and Lifetime Cost-Effectiveness of Intensity Modulated Radiation Therapy Versus 3-Dimensional Conformal Radiation Therapy for Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Kohler, Racquel E. [Department of Health Policy and Management, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Sheets, Nathan C. [Department of Radiation Oncology, University of North Carolina Hospitals, Chapel Hill, North Carolina (United States); Wheeler, Stephanie B. [Department of Health Policy and Management, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Nutting, Chris [Royal Marsden Hospital, London, United Kindom (United Kingdom); Hall, Emma [Clinical Trials and Statistics Unit, Division of Clinical Studies, Institute of Cancer Research, London (United Kingdom); Chera, Bhishamjit S., E-mail: bchera@med.unc.edu [Department of Radiation Oncology, University of North Carolina Hospitals, Chapel Hill, North Carolina (United States)

    2013-11-15

    Purpose: To assess the cost-effectiveness of intensity modulated radiation therapy (IMRT) versus 3-dimensional conformal radiation therapy (3D-CRT) in the treatment of head-and neck-cancer (HNC). Methods and Materials: We used a Markov model to simulate radiation therapy-induced xerostomia and dysphagia in a hypothetical cohort of 65-year-old HNC patients. Model input parameters were derived from PARSPORT (CRUK/03/005) patient-level trial data and quality-of-life and Medicare cost data from published literature. We calculated average incremental cost-effectiveness ratios (ICERs) from the US health care perspective as cost per quality-adjusted life-year (QALY) gained and compared our ICERs with current cost-effectiveness standards whereby treatment comparators less than $50,000 per QALY gained are considered cost-effective. Results: In the first 2 years after initial treatment, IMRT is not cost-effective compared with 3D-CRT, given an average ICER of $101,100 per QALY gained. However, over 15 years (remaining lifetime on the basis of average life expectancy of a 65-year-old), IMRT is more cost-effective at $34,523 per QALY gained. Conclusion: Although HNC patients receiving IMRT will likely experience reduced xerostomia and dysphagia symptoms, the small quality-of-life benefit associated with IMRT is not cost-effective in the short term but may be cost-effective over a patient's lifetime, assuming benefits persist over time and patients are healthy and likely to live for a sustained period. Additional data quantifying the long-term benefits of IMRT, however, are needed.

  18. Arsenic Methylation and Bladder Cancer Risk in CaseControl Studies in Argentina and the

    E-Print Network [OSTI]

    California at Berkeley, University of

    Arsenic Methylation and Bladder Cancer Risk in Case­Control Studies in Argentina and the United's susceptibility to bladder cancer. Methods: Urinary methylation products were measured in subjects from Argentina (114 cases and 114 controls) and the United States (23 cases and 49 controls). Results: In Argentina

  19. Increased lung cancer risks are similar whether arsenic is ingested ALLAN H. SMITHa

    E-Print Network [OSTI]

    California at Berkeley, University of

    Increased lung cancer risks are similar whether arsenic is ingested or inhaled ALLAN H. SMITHa that inorganic arsenic was a human lung carcinogen based on studies involving exposure through inhalation. In 2004, IARC listed arsenic in drinking water as a cause of lung cancer, making arsenic the first

  20. EPA`s program for risk assessment guidelines: Cancer classification issues

    SciTech Connect (OSTI)

    Wiltse, J.

    1990-12-31

    Issues presented are related to classification of weight of evidence in cancer risk assessments. The focus in this paper is on lines of evidence used in constructing a conclusion about potential human carcinogenicity. The paper also discusses issues that are mistakenly addressed as classification issues but are really part of the risk assessment process. 2 figs.

  1. Determination of Cancer Risk Associated with Germ Line BRCA1 Missense Variants by Functional Analysis

    E-Print Network [OSTI]

    Sali, Andrej

    Determination of Cancer Risk Associated with Germ Line BRCA1 Missense Variants by Functional Analysis Marcelo A. Carvalho, 1,3 Sylvia M. Marsillac, 1,4 Rachel Karchin, 6 Siranoush Manoukian, 7 Scott Andrej Sali, 13 David Goldgar, 14 Fergus J. Couch, 15 Paolo Radice, 7,8 and Alvaro N.A. Monteiro 1 1 Risk

  2. EXTRAPOLATING RADIATION-INDUCED CANCER RISKS FROM LOW DOSES TO VERY LOW DOSES

    E-Print Network [OSTI]

    Brenner, David Jonathan

    Paper EXTRAPOLATING RADIATION-INDUCED CANCER RISKS FROM LOW DOSES TO VERY LOW DOSES David J are increased at low doses ( 10 mGy). Discussed here are the issues related to extrapolating radiation risks from low radiation doses to very low doses (

  3. An association between the risk of ovarian cancer and rare HRAS1 alleles

    SciTech Connect (OSTI)

    Weitzel, J.N.; Patel, J.; Smith, D.M.

    1994-09-01

    The highly polymorphic HRAS1 minisatellite locus just downstream from the proto-oncogene H-ras-1 on chromosome 11p consists of four common progenitor alleles and several dozen rare alleles, which apparently derive from mutations of the progenitors. Mutant alleles of this locus represent a major risk factor for common types of cancer. Rare-sized HRAS1 alleles have been found more frequently in patients with carcinoma of the breast, colorectum, and urinary bladder and acute leukemia, compared to cancer-free controls. This highly significant association (p<1.001) results in a modest relative risk for patients with one rare allele, but the prevalence of this class of mutant alleles implies an important attributable risk: 1 in 11 cancers of the breast, colorectum, and bladder. Therefore, we performed a case-control study using conventional (Southern blot) and PCR-based methods to score HRAS1 alleles in the leukocyte DNA from 59 patients with ovarian cancer, and 51 cancer-free controls. Our preliminary data suggest an increased incidence of rare and intermediate HRAS1 alleles in caucasian ovarian cancer patients (13%) compared to cancer-free controls (4%). These results parallel the allele distribution seen in the large published series, and lend support for a significant association between rare HRAS1 alleles and ovarian cancer predisposition.

  4. Risk Factors Associated With Secondary Sarcomas in Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study

    SciTech Connect (OSTI)

    Henderson, Tara O.; Rajaraman, Preetha; Stovall, Marilyn; Constine, Louis S.; Olive, Aliza; Smith, Susan A.; Mertens, Ann; Meadows, Anna; Neglia, Joseph P.; Hammond, Sue; Whitton, John; Inskip, Peter D.; Robison, Leslie L.; Diller, Lisa

    2012-09-01

    Purpose: Childhood cancer survivors have an increased risk of secondary sarcomas. To better identify those at risk, the relationship between therapeutic dose of chemotherapy and radiation and secondary sarcoma should be quantified. Methods and Materials: We conducted a nested case-control study of secondary sarcomas (105 cases, 422 matched controls) in a cohort of 14,372 childhood cancer survivors. Radiation dose at the second malignant neoplasm (SMN) site and use of chemotherapy were estimated from detailed review of medical records. Odds ratios (ORs) and 95% confidence intervals were estimated by conditional logistic regression. Excess odds ratio (EOR) was modeled as a function of radiation dose, chemotherapy, and host factors. Results: Sarcomas occurred a median of 11.8 years (range, 5.3-31.3 years) from original diagnosis. Any exposure to radiation was associated with increased risk of secondary sarcoma (OR = 4.1, 95% CI = 1.8-9.5). A dose-response relation was observed, with elevated risks at doses between 10 and 29.9 Gy (OR = 15.6, 95% CI = 4.5-53.9), 30-49.9 Gy (OR = 16.0, 95% CI 3.8-67.8) and >50 Gy (OR = 114.1, 95% CI 13.5-964.8). Anthracycline exposure was associated with sarcoma risk (OR = 3.5, 95% CI = 1.6-7.7) adjusting for radiation dose, other chemotherapy, and primary cancer. Adjusting for treatment, survivors with a first diagnosis of Hodgkin lymphoma (OR = 10.7, 95% CI = 3.1-37.4) or primary sarcoma (OR = 8.4, 95% CI = 3.2-22.3) were more likely to develop a sarcoma. Conclusions: Of the risk factors evaluated, radiation exposure was the most important for secondary sarcoma development in childhood cancer survivors; anthracycline chemotherapy exposure was also associated with increased risk.

  5. [CANCER RESEARCH 61, 54205424, July 15, 2001] Modification of BRCA1-and BRCA2-associated Breast Cancer Risk by AIB1

    E-Print Network [OSTI]

    Brown, Myles

    [CANCER RESEARCH 61, 5420­5424, July 15, 2001] Modification of BRCA1- and BRCA2-associated Breast/2) genes have a greatly increased risk of developing breast cancer compared with the general population. However, there is also substantial interindividual variability in the occurrence of breast cancer among

  6. Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk

    E-Print Network [OSTI]

    Painter, Jodie N.; O’Mara, Tracy A.; Batra, Jyotsna; Cheng, Timothy; Lose, Felicity A.; Dennis, Joe; Michailidou, Kyriaki; Tyrer, Jonathan P.; Ahmed, Shahana; Ferguson, Kaltin; Healey, Catherine S.; Kaufmann, Susanne; Hillman, Kristine M.; Walpole, Carina; Moya, Carina; Pollock, Pamela; Jones, Angela; Howarth, Kimberley; Martin, Lynn; Gorman, Maggie; Hodgson, Shirley; National Study of Endometrial Cancer Genetics Group (NSECG); CHIBCHA Consortium; de Polanco, Ma. Magdalena Echeverry; Sans, Monica; Carracedo, Angel; Castellvi-Bel, Sergi; Rojas-Martinez, Augusto; Santos, Erika; Teixeira, Manuel R.; Carvajal-Carmona, Luis; Shu, Xiao-Ou; Long, Jirong; Zheng, Wei; Xiang, Yong-Bing; The Australian National Endometrial Cancer Study Group (ANECS); Montgomery, Grant W.; Webb, Penelope M.; Scott, Rodney J.; McEvoy, Mark; Attia, John; Holliday, Elizabeth; Martin, Nicholas G.; Nyholt, Dale R.; Henders, Anjali K.; Fasching, Peter A.; Hein, Alexander; Beckmann, Matthias W.; Renner, Stefan P.; Dörk, Thilo; Hillemanns, Peter; Dürst, Matthias; Runnebaum, Ingo; Lambrechts, Diether; Coenegrachts, Lieve; Schrauwen, Stefanie; Amant, Frederic; Winterhoff, Boris; Dowdy, Sean C.; Goode, Ellen L.; Teoman, Attila; Salvesen, Helga B.; Trovik, Jone; Njolstad, Tormund S.; Werner, Henrica M. J.; Ashton, Katie; Proietto, Tony; Otton, Geoffrey; Tzortzatos, Gerasimos; Mints, Miriam; Tham, Emma; RENDOCAS; Hall, Per; Czene, Kamila; Liu, Jianjun; Li, Jingmei; Hopper, John L.; Southey, Melissa C.; Australian Ovarian Cancer Study (AOCS); Ekici, Arif B.; Ruebner, Matthias; Johnson, Nicola; Peto, Julian; Burwinkel, Barbara; Marme, Frederik; Brenner, Hermann; Dieffenbach, Aida K.; Meindl, Alfons; Brauch, Hiltrud; The GENICA Network; Lindblom, Annika; Depreeuw, Jeroen; Moisse, Matthieu; Chang-Claude, Jenny; Rudolph, Anja; Couch, Fergus J.; Olson, Janet E.; Giles, Graham G.; Bruinsma, Fiona; Cunningham, Julie M.; Fridley, Brooke L.; Břrresen-Dale, Anne-Lise; Kristensen, Vessela N.; Cox, Angela; Swerdlow, Anthony J.; Orr, Nicholas; Bolla, Manjeet K.; Wang, Qin; Weber, Rachel Palmieri; Chen, Zhihua; Shah, Mitul; French, Juliet D.; Pharoah, Paul D. P.; Dunning, Alison M.; Tomlinson, Ian; Easton, Douglas F.; Edwards, Stacey L.; Thompson, Deborah J.; Spurdle, Amanda B.

    2014-11-06

    Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B...

  7. SU-D-9A-07: Imaging Dose and Cancer Risk in Image-Guided Radiotherapy of Cancers

    SciTech Connect (OSTI)

    Zhou, L; Bai, S; Zhang, Y; Ming, X; Zhang, Y; Deng, J

    2014-06-01

    Purpose: To systematically evaluate the imaging doses and cancer risks associated with various imaging procedures involving ionizing radiation during image-guided radiotherapy of an increasingly large number of cancer patients. Methods: 141 patients (52 brain cases, 47 thoracic cases, 42 abdominal cases, aged 3 to 91 years old) treated between October 2009 and March 2010 were included in this IRB-approved retrospective study. During the whole radiotherapy course, each patient underwent at least one type of imaging procedures, i.e., kV portal, MV portal and kVCBCT, besides CT simulations. Based on Monte Carlo modeling and particle transport in human anatomy of various dimensions, the correlations between the radiation doses to the various organs-at-risk (OARs) at the head, the thoracic and the abdominal regions and one's weight, circumference, scan mAs and kVp have been obtained and used to estimate the radiation dose from a specific imaging procedure. The radiation-induced excess relative risk (ERR) was then estimated with BEIR VII formulism based on one's gender, age and radiation dose. 1+ ERR was reported in this study as relative cancer risk. Results: For the whole cohort of 141 patients, the mean imaging doses from various imaging procedures were 8.3 cGy to the brain, 10.5 cGy to the lungs and 19.2 cGy to the red bone marrow, respectively. Accordingly, the cancer risks were 1.140, 1.369 and 2.671, respectively. In comparison, MV portal deposited largest doses to the lungs while kVCBCT delivered the highest doses to the red bone marrow. Conclusion: The compiled imaging doses to a patient during his/her treatment course were patient-specific and site-dependent, varying from 1.2 to 263.5 cGy on average, which were clinically significant and should be included in the treatment planning and overall decision-making. Our results indicated the necessity of personalized imaging to maximize its clinical benefits while reducing the associated cancer risks. Sichuan University Scholarship.

  8. Screening for ovarian cancer in women with varying levels of risk, using annual tests, results in high recall for repeat screening tests.

    E-Print Network [OSTI]

    Nobbenhuis, Marielle A. E.; Bancroft, Elizabeth; Moskovic, Eleanor; Lennard, Fiona; Pharoah, Paul D. P.; Jacobs, Ian; Ward, Ann; Barton, Desmond P. J.; Ind, Thomas E. J.; Shepherd, John H.; Bridges, Jane E.; Gore, Martin; Haracopos, Chris; Shanley, Susan; Ardern-Jones, Audrey; Thomas, Sarah; Eeles, Rosalind A.

    2011-11-23

    Abstract Background We assessed ovarian cancer screening outcomes in women with a positive family history of ovarian cancer divided into a low-, moderate- or high-risk group for development of ovarian cancer. Methods 545 women with a positive family...

  9. Parental occupational exposures and risk of childhood cancer: A review

    SciTech Connect (OSTI)

    O'Leary, L.M.; Hicks, A.M.; Peters, J.M.; London, S. (University of Southern California School of Medicine, Los Angeles (USA))

    1991-01-01

    The authors reviewed the literature in order to summarize the present knowledge on the association between parental occupational exposures to chemicals and the risk of childhood malignancy. The 32 studies pertaining to this topic were evaluated by considering various study qualities such as sample size, specificity of outcome, confounding, exposure specificity, and control selection. When evaluating the findings from any epidemiologic study, the potential sources of bias have to be considered. The selection of subjects, misclassification of exposure or outcome, and confounding from extraneous factors can contribute to a biased estimate of effect. Studies done to minimize these potential biases will be more valid, and these studies should be given the most weight when parental occupational exposures are evaluated as risk factors for childhood malignancy. We conclude that the preponderance of evidence supports the hypothesis that occupational exposure of parents to chemicals increases the risk of childhood malignancy. The parental occupational exposures implicated in childhood malignancy risk are exposure to chemicals including paints, petroleum products, solvents (especially chlorinated hydrocarbons) and pesticides, and exposure to metals. The available data do not allow the identification of specific etiologic agents within these categories of compounds. Future epidemiologic and toxicologic studies should be designed to pursue these leads. 49 references.

  10. Breast Cancer After Treatment of Hodgkin's Lymphoma: Risk Factors That Really Matter

    SciTech Connect (OSTI)

    Alm El-Din, Mohamed A. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Hughes, Kevin S. [Department of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Finkelstein, Dianne M.; Betts, Keith A. [Department of Biostatistics, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Yock, Torunn I.; Tarbell, Nancy J. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Aisenberg, Alan C. [Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Taghian, Alphonse G. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States)], E-mail: ataghian@partners.org

    2009-01-01

    Purpose: To evaluate the risk of breast cancer (BC) and the contributing risk factors in women after supradiaphragmatic irradiation (SDI) for Hodgkin's lymphoma (HL). Subjects and Methods: Medical records of 248 women 60 years of age or less who received SDI for stage I/II HL between 1964 and 2001 at Massachusetts General Hospital were retrospectively reviewed. Results: The median age at SDI was 26 years (range, 5.7-59.3). The median follow-up was 15.2 years (range, 0.1-41.3). In 36 patients, BC developed (bilaterally in 11 patients) at a median interval of 18.4 years (range, 4.3-33.8) after SDI. Based on data from the National Cancer Institute Surveillance, Epidemiology, and End Results program, the standardized morbidity ratio (SMR) for the first BC after SDI was 9.78 (95% confidence interval [CI], 4.64-18.11, p < 0.0001). The SMR of patients who received radiation before age of 30 years was 19.05 (95% CI, 12.33-28.13) compared with 4.64 (95% CI, 2.31-8.30) for patients aged 30 years or more at the time of treatment (p < 0.00003). Risk for BC was significantly higher 15 years or more after SDI compared with the risk during the first 15 years (p = 0.0026). None of HL characteristics or treatment details was associated with higher risk of BC after adjusting for age and calendar time. Conclusions: Age at irradiation and time since therapy appear to be the only significant risk factors for development of BC after treatment of HL. The risk is significantly higher 15 years or more after radiation and for women treated before age 30 years. Long-term surveillance strategies are indicated for women at risk.

  11. Residential Mobility and Lung Cancer Risk: Data-Driven Exploration Using Internet Sources

    SciTech Connect (OSTI)

    Yoon, Hong-Jun; Tourassi, Georgia; Xu, Songhua

    2015-01-01

    Frequent relocation has been linked to health decline, particularly with respect to emotional and psychological wellbeing. In this paper we investigate whether there is an association between frequent relocation and lung cancer risk. For the initial investigation we leverage two online data sources to collect cancer and control subjects using web crawling and tailored text mining. The two data sources share different strengths and weaknesses in terms of the amount of detail, population representation, and sample size. One data source includes online obituaries. The second data source includes augmented LinkedIn profiles. For each data source, the subjects spatiotemporal history is reconstructed from the available information provided in the obituaries and from the education and work experience provided in the LinkedIn profiles. The study shows that lung cancer subjects have higher mobility frequency than the control group. This trend is consistent for both data sources.

  12. Percentage of Positive Biopsy Cores: A Better Risk Stratification Model for Prostate Cancer?

    SciTech Connect (OSTI)

    Huang Jiayi; Vicini, Frank A. [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Williams, Scott G. [Peter Maccallum Cancer Centre and University of Melbourne, Melbourne, Victoria (Australia); Ye Hong; McGrath, Samuel; Ghilezan, Mihai; Krauss, Daniel; Martinez, Alvaro A. [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Kestin, Larry L., E-mail: lkestin@comcast.net [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States)

    2012-07-15

    Purpose: To assess the prognostic value of the percentage of positive biopsy cores (PPC) and perineural invasion in predicting the clinical outcomes after radiotherapy (RT) for prostate cancer and to explore the possibilities to improve on existing risk-stratification models. Methods and Materials: Between 1993 and 2004, 1,056 patients with clinical Stage T1c-T3N0M0 prostate cancer, who had four or more biopsy cores sampled and complete biopsy core data available, were treated with external beam RT, with or without a high-dose-rate brachytherapy boost at William Beaumont Hospital. The median follow-up was 7.6 years. Multivariate Cox regression analysis was performed with PPC, Gleason score, pretreatment prostate-specific antigen, T stage, PNI, radiation dose, androgen deprivation, age, prostate-specific antigen frequency, and follow-up duration. A new risk stratification (PPC classification) was empirically devised to incorporate PPC and replace the T stage. Results: On multivariate Cox regression analysis, the PPC was an independent predictor of distant metastasis, cause-specific survival, and overall survival (all p < .05). A PPC >50% was associated with significantly greater distant metastasis (hazard ratio, 4.01; 95% confidence interval, 1.86-8.61), and its independent predictive value remained significant with or without androgen deprivation therapy (all p < .05). In contrast, PNI and T stage were only predictive for locoregional recurrence. Combining the PPC ({<=}50% vs. >50%) with National Comprehensive Cancer Network risk stratification demonstrated added prognostic value of distant metastasis for the intermediate-risk (hazard ratio, 5.44; 95% confidence interval, 1.78-16.6) and high-risk (hazard ratio, 4.39; 95% confidence interval, 1.70-11.3) groups, regardless of the use of androgen deprivation and high-dose RT (all p < .05). The proposed PPC classification appears to provide improved stratification of the clinical outcomes relative to the National Comprehensive Cancer Network classification. Conclusions: The PPC is an independent and powerful predictor of clinical outcomes of prostate cancer after RT. A risk model replacing T stage with the PPC to reduce subjectivity demonstrated potentially improved stratification.

  13. HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm

    E-Print Network [OSTI]

    Full Paper HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk patients as presenting a high or low risk for epithelial ovarian cancer (EOC). We validated this algorithm, measurement of HE4 serum levels does not contribute to the diagnosis of ovarian cancer. British Journal

  14. Three-dimensional fluorescence lifetime tomography

    SciTech Connect (OSTI)

    Godavarty, Anuradha; Sevick-Muraca, Eva M.; Eppstein, Margaret J. [327 Votey Building, Department of Computer Science, University of Vermont, Burlington, Vermont 05405 (United States); 1011 Richardson Building, Photon Migration Laboratories, Texas A and M University, College Station, Texas 77843 (United States); 327 Votey Building, Department of Computer Science, University of Vermont, Burlington, Vermont 05405 (United States)

    2005-04-01

    Near-infrared fluorescence tomography using molecularly targeted lifetime-sensitive, fluorescent contrast agents have applications for early-stage cancer diagnostics. Yet, although the measurement of fluorescent lifetime imaging microscopy (FLIM) is extensively used in microscopy and spectroscopy applications, demonstration of fluorescence lifetime tomography for medical imaging is limited to two-dimensional studies. Herein, the feasibility of three-dimensional fluorescence-lifetime tomography on clinically relevant phantom volumes is established, using (i) a gain-modulated intensified charge coupled device (CCD) and modulated laser diode imaging system, (ii) two fluorescent contrast agents, e.g., Indocyanine green and 3-3'-Diethylthiatricarbocyanine iodide differing in their fluorescence lifetime by 0.62 ns, and (iii) a two stage approximate extended Kalman filter reconstruction algorithm. Fluorescence measurements of phase and amplitude were acquired on the phantom surface under different target to background fluorescence absorption (70:1, 100:1) and fluorescence lifetime (1:1, 2.1:1) contrasts at target depths of 1.4-2 cm. The Bayesian tomography algorithm was employed to obtain three-dimensional images of lifetime and absorption owing to the fluorophores.

  15. Global and local cancer risks after the Fukushima Nuclear Power Plant accident as seen from Chernobyl: A modeling study for

    E-Print Network [OSTI]

    Mousseau, Timothy A.

    Global and local cancer risks after the Fukushima Nuclear Power Plant accident as seen from-model Death risks The accident at the Fukushima Daiichi Nuclear Power Plant (NPP) in Japan resulted with iodine isotopes and noble gasses) after nuclear releases. The main purpose is to provide preliminary

  16. Lifetimes of noisy repellors

    E-Print Network [OSTI]

    H. Faisst; B. Eckhardt

    2003-08-27

    We study the effects of additive noise on the lifetimes of chaotic repellors. Using first order perturbation theory we argue that noise will increase the lifetime if the escape holes lie in regions where the unperturbed density is higher than in the immediate vicinity and that it decreases if the density is lower. Numerical experiments support the qualitative conclusions also beyond perturbation theory.

  17. Reproductive Status at First Diagnosis Influences Risk of Radiation-Induced Second Primary Contralateral Breast Cancer in the WECARE Study

    SciTech Connect (OSTI)

    Brooks, Jennifer D.; Boice, John D.; Stovall, Marilyn; Reiner, Anne S.; Bernstein, Leslie; John, Esther M.; Lynch, Charles F.; Mellemkjaer, Lene; Knight, Julia A.; Thomas, Duncan C.; Haile, Robert W.; Smith, Susan A.; Capanu, Marinela; Bernstein, Jonine L.; Shore, Roy E.; Radiation Effects Research Foundation, Hiroshima

    2012-11-15

    Purpose: Our study examined whether reproductive and hormonal factors before, at the time of, or after radiation treatment for a first primary breast cancer modify the risk of radiation-induced second primary breast cancer. Methods and Materials: The Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study is a multicenter, population-based study of 708 women (cases) with asynchronous contralateral breast cancer (CBC) and 1399 women (controls) with unilateral breast cancer. Radiotherapy (RT) records, coupled with anthropomorphic phantom simulations, were used to estimate quadrant-specific radiation dose to the contralateral breast for each patient. Rate ratios (RR) and 95% confidence intervals (CI) were computed to assess the relationship between reproductive factors and risk of CBC. Results: Women who were nulliparous at diagnosis and exposed to {>=}1 Gy to the contralateral breast had a greater risk for CBC than did matched unexposed nulliparous women (RR = 2.2; 95% CI, 1.2-4.0). No increased risk was seen in RT-exposed parous women (RR = 1.1; 95% CI, 0.8-1.4). Women treated with RT who later became pregnant (8 cases and 9 controls) had a greater risk for CBC (RR = 6.0; 95% CI, 1.3-28.4) than unexposed women (4 cases and 7 controls) who also became pregnant. The association of radiation with risk of CBC did not vary by number of pregnancies, history of breastfeeding, or menopausal status at the time of first breast cancer diagnosis. Conclusion: Nulliparous women treated with RT were at an increased risk for CBC. Although based on small numbers, women who become pregnant after first diagnosis also seem to be at an increased risk for radiation-induced CBC.

  18. Rare alleles of the HRAS polymorphism do not modify the risk of breast or ovarian cancer in BRCA1 carriers

    SciTech Connect (OSTI)

    Phelan, C.; Tonin, P.; Lynch, H.T.

    1994-09-01

    The presence of one of the rare alleles of a minisatellite polymorphism at the HRAS locus on chromosome 11p15 has been associated with a roughly two-fold increase in the risk of breast cancer. The BRCA1 gene on chromosome 17q12-21 is responsible for the majority of the families with the breast-ovarian cancer syndrome. It is estimated that 87% of BRCA1 carriers will be affected with breast cancer by age 70. The relative risk for premenopausal breast cancer in carriers, compared to non-carriers, is roughly 100. Because of the wide range in ages of onset of cancer among BRCA1 carriers, it is likely that additional factors modify the risk of cancer. The role of other modifying genetic loci has not been studied. Through haplotype analysis we have identified 199 female BRCA1 carriers above the age of 20 years in 25 linked families. 127 of these women have been diagnosed with cancer and 72 are currently healthy. DNA was available on 59 carriers. Each sample was typed for the HRAS polymorphism by PCR, using primers flanking the minisatellite. Rare alleles were identified in 18 carriers. The penetrance of the BRCA1 gene was not higher among those women who carried a rare HRAS allele (mean age of onset 49 years) than among those who carried two common alleles (mean age of onset 43 years) (p= 0.59; log rank test). Similar results were obtained for ovarian cancer. These data do not support the hypothesis that the HRAS locus modified the risk of cancer among carriers of mutations in BRCA1.

  19. Health anxiety and cognitive processes as risks for insomnia in women undergoing chemotherapy for breast cancer

    E-Print Network [OSTI]

    Rissling, Michelle Brosemer; Rissling, Michelle Brosemer

    2012-01-01

    symptom cluster in breast cancer patients is associated withFatigue and Sleep in Breast Cancer Patients Undergoingwomen with metastatic breast cancer. The breast journal, 8(

  20. Asbestos exposure--quantitative assessment of risk

    SciTech Connect (OSTI)

    Hughes, J.M.; Weill, H.

    1986-01-01

    Methods for deriving quantitative estimates of asbestos-associated health risks are reviewed and their numerous assumptions and uncertainties described. These methods involve extrapolation of risks observed at past relatively high asbestos concentration levels down to usually much lower concentration levels of interest today--in some cases, orders of magnitude lower. These models are used to calculate estimates of the potential risk to workers manufacturing asbestos products and to students enrolled in schools containing asbestos products. The potential risk to workers exposed for 40 yr to 0.5 fibers per milliliter (f/ml) of mixed asbestos fiber type (a permissible workplace exposure limit under consideration by the Occupational Safety and Health Administration (OSHA) ) are estimated as 82 lifetime excess cancers per 10,000 exposed. The risk to students exposed to an average asbestos concentration of 0.001 f/ml of mixed asbestos fiber types for an average enrollment period of 6 school years is estimated as 5 lifetime excess cancers per one million exposed. If the school exposure is to chrysotile asbestos only, then the estimated risk is 1.5 lifetime excess cancers per million. Risks from other causes are presented for comparison; e.g., annual rates (per million) of 10 deaths from high school football, 14 from bicycling (10-14 yr of age), 5 to 20 for whooping cough vaccination. Decisions concerning asbestos products require participation of all parties involved and should only be made after a scientifically defensible estimate of the associated risk has been obtained. In many cases to date, such decisions have been made without adequate consideration of the level of risk or the cost-effectiveness of attempts to lower the potential risk. 73 references.

  1. The Neutron Lifetime

    E-Print Network [OSTI]

    F. E. Wietfeldt

    2014-11-13

    The decay of the free neutron into a proton, electron, and antineutrino is the prototype semileptonic weak decay and the simplest example of nuclear beta decay. The nucleon vector and axial vector weak coupling constants G_V and G_A determine the neutron lifetime as well as the strengths of weak interaction processes involving free neutrons and protons that are important in astrophysics, cosmology, solar physics and neutrino detection. In combination with a neutron decay angular correlation measurement, the neutron lifetime can be used to determine the first element of the CKM matrix Vud. Unfortunately the two main experimental methods for measuring the neutron lifetime currently disagree by almost 4 sigma. I will present a brief review of the status of the neutron lifetime and prospects for the future.

  2. Evidence That New Hypnotics Cause Cancer

    E-Print Network [OSTI]

    Kripke, Daniel F.

    2008-01-01

    use and risk of epithelial ovarian cancer. Cancer Epidemiol.and risk of epithelial ovarian cancer: evidence from twowere associated with ovarian cancer (Harlow et al. 1998;

  3. Chapter 16: Log-linear regression for Poisson counts Exposure to ionizing radiation is recognized as a cancer risk. In the United States, EPA

    E-Print Network [OSTI]

    Bardsley, John

    as a cancer risk. In the United States, EPA sets guidelines specifying upper limits on the amount of exposure groups than low exposure. The objective of regression analysis is to estimate the rate of cancer deaths cases or deaths attributable to cancer) using a number of explanatory variables believed to be related

  4. Risk Factors of Developing Long-Lasting Breast Pain After Breast Cancer Radiotherapy

    SciTech Connect (OSTI)

    Lundstedt, Dan; Gustafsson, Magnus; Steineck, Gunnar; Malmstroem, Per; Alsadius, David; Sundberg, Agnetha; Wilderaeng, Ulrica; Holmberg, Erik; Johansson, Karl-Axel; Karlsson, Per

    2012-05-01

    Purpose: Postoperative radiotherapy decreases breast cancer mortality. However, studies have revealed a long-lasting breast pain among some women after radiotherapy. The purpose of this study was to identify risk factors that contribute to breast pain after breast cancer radiotherapy. Methods and Materials: We identified 1,027 recurrence-free women in two cohorts of Swedish women treated for breast cancer. The women had breast-conserving surgery and postoperative radiotherapy, the breast was treated to 48 Gy in 2.4-Gy fractions or to 50 Gy in 2.0-Gy fractions. Young women received a boost of up to 16 Gy. Women with more than three lymph node metastases had locoregional radiotherapy. Systemic treatments were given according to health-care guidelines. Three to 17 years after radiotherapy, we collected data using a study-specific questionnaire. We investigated the relation between breast pain and potential risk modifiers: age at treatment, time since treatment, chemotherapy, photon energy, fractionation size, boost, loco-regional radiotherapy, axillary surgery, overweight, and smoking. Results: Eight hundred seventy-seven women (85%) returned the questionnaires. Among women up to 39 years of age at treatment, 23.1% had breast pain, compared with 8.7% among women older than 60 years (RR 2.66; 95% CI 1.33-5.36). Higher age at treatment (RR 0.96; 95% CI 0.94-0.98, annual decrease) and longer time since treatment (RR 0.93; 95% CI 0.88-0.98, annual decrease) were related to a lower occurrence of breast pain. Chemotherapy increased the occurrence of breast pain (RR 1.72; 95% CI 1.19-2.47). In the multivariable model only age and time since treatment were statistically significantly related to the occurrence of breast pain. We found no statistically significant relation between breast pain and the other potential risk modifiers. Conclusions: Younger women having undergone breast-conserving surgery with postoperative radiotherapy report a higher occurrence of long-lasting breast pain compared to older women. Time since treatment may decrease the occurrence of pain.

  5. PHOSPHOLIPID AND TRIACYLGLYCEROL FATTY ACIDS IN BLOOD AND BREAST TISSUE OBTAINED FROM WOMEN AT INCREASED RISK OF BREAST CANCER

    E-Print Network [OSTI]

    Li, Shengqi

    2010-06-08

    The purpose of this study was to determine the fatty acids composition in breast tissue of women with increased risk of breast cancer, and if the fatty acid composition in both PL and TAG in blood, both plasma and RBC, correlated to the fatty acid...

  6. Phase 1 Trial of Neoadjuvant Radiation Therapy Before Prostatectomy for High-Risk Prostate Cancer

    SciTech Connect (OSTI)

    Koontz, Bridget F., E-mail: Bridget.Koontz@duke.edu [Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina (United States); Duke Prostate Center, Duke Cancer Institute, Durham, North Carolina (United States); Quaranta, Brian P. [21st Century Oncology, Asheville, North Carolina (United States); Pura, John A. [Division of Biostatistics, Duke Cancer Institute, Durham, North Carolina (United States); Lee, W.R.; Vujaskovic, Zeljko [Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina (United States); Duke Prostate Center, Duke Cancer Institute, Durham, North Carolina (United States); Gerber, Leah [Duke Prostate Center, Duke Cancer Institute, Durham, North Carolina (United States); Haake, Michael [Southeast Radiation Oncology, Charlotte, North Carolina (United States); Anscher, Mitchell S. [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia (United States); Robertson, Cary N.; Polascik, Thomas J.; Moul, Judd W. [Department of Surgery, Duke Cancer Institute, Durham, North Carolina (United States); Duke Prostate Center, Duke Cancer Institute, Durham, North Carolina (United States)

    2013-09-01

    Purpose: To evaluate, in a phase 1 study, the safety of neoadjuvant whole-pelvis radiation therapy (RT) administered immediately before radical prostatectomy in men with high-risk prostate cancer. Methods and Materials: Twelve men enrolled and completed a phase 1 single-institution trial between 2006 and 2010. Eligibility required a previously untreated diagnosis of localized but high-risk prostate cancer. Median follow-up was 46 months (range, 14-74 months). Radiation therapy was dose-escalated in a 3 × 3 design with dose levels of 39.6, 45, 50.4, and 54 Gy. The pelvic lymph nodes were treated up to 45 Gy with any additional dose given to the prostate and seminal vesicles. Radical prostatectomy was performed 4-8 weeks after RT completion. Primary outcome measure was intraoperative and postoperative day-30 morbidity. Secondary measures included late morbidity and oncologic outcomes. Results: No intraoperative morbidity was seen. Chronic urinary grade 2+ toxicity occurred in 42%; 2 patients (17%) developed a symptomatic urethral stricture requiring dilation. Two-year actuarial biochemical recurrence-free survival was 67% (95% confidence interval 34%-86%). Patients with pT3 or positive surgical margin treated with neoadjuvant RT had a trend for improved biochemical recurrence-free survival compared with a historical cohort with similar adverse factors. Conclusions: Neoadjuvant RT is feasible with moderate urinary morbidity. However, oncologic outcomes do not seem to be substantially different from those with selective postoperative RT. If this multimodal approach is further evaluated in a phase 2 setting, 54 Gy should be used in combination with neoadjuvant androgen deprivation therapy to improve biochemical outcomes.

  7. Causes of Mortality After Dose-Escalated Radiation Therapy and Androgen Deprivation for High-Risk Prostate Cancer

    SciTech Connect (OSTI)

    Tendulkar, Rahul D.; Hunter, Grant K.; Reddy, Chandana A.; Stephans, Kevin L.; Ciezki, Jay P.; Abdel-Wahab, May; Stephenson, Andrew J.; Klein, Eric A.; Mahadevan, Arul; Kupelian, Patrick A.

    2013-09-01

    Purpose: Men with high-risk prostate cancer have other competing causes of mortality; however, current risk stratification schema do not account for comorbidities. We aim to identify the causes of death and factors predictive for mortality in this population. Methods and Materials: A total of 660 patients with high-risk prostate cancer were treated with definitive high-dose external beam radiation therapy (?74 Gy) and androgen deprivation (AD) between 1996 and 2009 at a single institution. Cox proportional hazards regression analysis was conducted to determine factors predictive of survival. Results: The median radiation dose was 78 Gy, median duration of AD was 6 months, and median follow-up was 74 months. The 10-year overall survival (OS) was 60.6%. Prostate cancer was the leading single cause of death, with 10-year mortality of 14.1% (95% CI 10.7-17.6), compared with other cancers (8.4%, 95% CI 5.7-11.1), cardiovascular disease (7.3%, 95% CI 4.7-9.9), and all other causes (10.4%, 95% CI 7.2-13.6). On multivariate analysis, older age (HR 1.55, P=.002) and Charlson comorbidity index score (CS) ?1 (HR 2.20, P<.0001) were significant factors predictive of OS, whereas Gleason score, T stage, prostate-specific antigen, duration of AD, radiation dose, smoking history, and body mass index were not. Men younger than 70 years of age with CS = 0 were more likely to die of prostate cancer than any other cause, whereas older men or those with CS ?1 more commonly suffered non-prostate cancer death. The cumulative incidences of prostate cancer-specific mortality were similar regardless of age or comorbidities (P=.60). Conclusions: Men with high-risk prostate cancer are more likely to die of causes other than prostate cancer, except for the subgroup of men younger than 70 years of age without comorbidities. Only older age and presence of comorbidities significantly predicted for OS, whereas prostate cancer- and treatment-related factors did not.

  8. Is Androgen Deprivation Therapy Necessary in All Intermediate-Risk Prostate Cancer Patients Treated in the Dose Escalation Era?

    SciTech Connect (OSTI)

    Castle, Katherine O.; Hoffman, Karen E.; Levy, Lawrence B.; Lee, Andrew K.; Choi, Seungtaek; Nguyen, Quynh N.; Frank, Steven J.; Pugh, Thomas J.; McGuire, Sean E.; Kuban, Deborah A.

    2013-03-01

    Purpose: The benefit of adding androgen deprivation therapy (ADT) to dose-escalated radiation therapy (RT) for men with intermediate-risk prostate cancer is unclear; therefore, we assessed the impact of adding ADT to dose-escalated RT on freedom from failure (FFF). Methods: Three groups of men treated with intensity modulated RT or 3-dimensional conformal RT (75.6-78 Gy) from 1993-2008 for prostate cancer were categorized as (1) 326 intermediate-risk patients treated with RT alone, (2) 218 intermediate-risk patients treated with RT and ?6 months of ADT, and (3) 274 low-risk patients treated with definitive RT. Median follow-up was 58 months. Recursive partitioning analysis based on FFF using Gleason score (GS), T stage, and pretreatment PSA concentration was applied to the intermediate-risk patients treated with RT alone. The Kaplan-Meier method was used to estimate 5-year FFF. Results: Based on recursive partitioning analysis, intermediate-risk patients treated with RT alone were divided into 3 prognostic groups: (1) 188 favorable patients: GS 6, ?T2b or GS 3+4, ?T1c; (2) 71 marginal patients: GS 3+4, T2a-b; and (3) 68 unfavorable patients: GS 4+3 or T2c disease. Hazard ratios (HR) for recurrence in each group were 1.0, 2.1, and 4.6, respectively. When intermediate-risk patients treated with RT alone were compared to intermediate-risk patients treated with RT and ADT, the greatest benefit from ADT was seen for the unfavorable intermediate-risk patients (FFF, 74% vs 94%, respectively; P=.005). Favorable intermediate-risk patients had no significant benefit from the addition of ADT to RT (FFF, 94% vs 95%, respectively; P=.85), and FFF for favorable intermediate-risk patients treated with RT alone approached that of low-risk patients treated with RT alone (98%). Conclusions: Patients with favorable intermediate-risk prostate cancer did not benefit from the addition of ADT to dose-escalated RT, and their FFF was nearly as good as patients with low-risk disease. In patients with GS 4+3 or T2c disease, the addition of ADT to dose-escalated RT did improve FFF.

  9. Estrogen withdrawal, increased breast cancer risk and the KRAS-variant

    E-Print Network [OSTI]

    2015-01-01

    menopausal women 3 and ovarian cancer. 4-6 The KRAS-variantvariant patients with ovarian cancer or head and neck cancerincluding breast and ovarian cancer, as well as a third

  10. Risk of Cerebrovascular Events in Elderly Patients After Radiation Therapy Versus Surgery for Early-Stage Glottic Cancer

    SciTech Connect (OSTI)

    Hong, Julian C.; Kruser, Tim J.; Gondi, Vinai; Mohindra, Pranshu; Cannon, Donald M.; Harari, Paul M.; Bentzen, Sřren M.

    2013-10-01

    Purpose: Comprehensive neck radiation therapy (RT) has been shown to increase cerebrovascular disease (CVD) risk in advanced-stage head-and-neck cancer. We assessed whether more limited neck RT used for early-stage (T1-T2 N0) glottic cancer is associated with increased CVD risk, using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. Methods and Materials: We identified patients ?66 years of age with early-stage glottic laryngeal cancer from SEER diagnosed from 1992 to 2007. Patients treated with combined surgery and RT were excluded. Medicare CPT codes for carotid interventions, Medicare ICD-9 codes for cerebrovascular events, and SEER data for stroke as the cause of death were collected. Similarly, Medicare CPT and ICD-9 codes for peripheral vascular disease (PVD) were assessed to serve as an internal control between treatment groups. Results: A total of 1413 assessable patients (RT, n=1055; surgery, n=358) were analyzed. The actuarial 10-year risk of CVD was 56.5% (95% confidence interval 51.5%-61.5%) for the RT cohort versus 48.7% (41.1%-56.3%) in the surgery cohort (P=.27). The actuarial 10-year risk of PVD did not differ between the RT (52.7% [48.1%-57.3%]) and surgery cohorts (52.6% [45.2%-60.0%]) (P=.89). Univariate analysis showed an increased association of CVD with more recent diagnosis (P=.001) and increasing age (P=.001). On multivariate Cox analysis, increasing age (P<.001) and recent diagnosis (P=.002) remained significantly associated with a higher CVD risk, whereas the association of RT and CVD remained not statistically significant (HR=1.11 [0.91-1.37,] P=.31). Conclusions: Elderly patients with early-stage laryngeal cancer have a high burden of cerebrovascular events after surgical management or RT. RT and surgery are associated with comparable risk for subsequent CVD development after treatment in elderly patients.

  11. Plasma Vitamin D and Prostate Cancer Risk: Results from the Selenium and Vitamin E Cancer Prevention Trial

    E-Print Network [OSTI]

    2014-01-01

    Biomarkers & Prevention Plasma Vitamin D and Prostate Cancerfrom the Selenium and Vitamin E Cancer Prevention Trial Alanwho are using supplemental vitamin D should limit their dose

  12. Breast cancer and personal environmental risk factors in Marin County - Pilot study

    SciTech Connect (OSTI)

    Erdmann, C.A.; Farren, G.; Baltzell, K.; Chew, T.; Clarkson, C.; Fleshman, R.; Leary, C.; Mizroch, M.; Orenstein, F.; Russell, M.L.; Souders-Mason, V.; Wrensch, M.

    2003-02-01

    The purpose of the Personal Environmental Risk Factor Study (PERFS) pilot project was to develop methodologies and a questionnaire for a future population-based case-control study to investigate the role of selected environmental exposures in breast cancer development. Identification of etiologically relevant exposures during a period of potential vulnerability proximate to disease onset offers the possibility of clinical disease prevention even when disease initiation may have already occurred many years earlier. Certain personal environmental agents or combinations of agents may influence disease promotion. Therefore, this pilot study focused on exposures that occurred during the ten-year period prior to diagnosis for cases and the last ten years for controls, rather than more historic exposures. For this pilot study, they used a community-based research approach. In the collaborative efforts, community members participated with academic researchers in all phases of the research, including research question identification, study design, development of research tools, development of the human subjects protocol, and report writing. Community member inclusion was based upon the concept that community participation could improve the relevance of scientific studies and ultimate success of the research by encouraging an ongoing dialogue between community members and academic representatives. Early activities of this project focused on the collection of input from the community regarding the possible role of environmental factors in the incidence of breast cancer in Marin County. The intent was to inform the scientists of community concerns, enhance the research team's understanding of the community being studied, and provide interested community members with a better understanding of the strengths and weaknesses of traditional research methods through active participation in the research process.

  13. Reference computations of public dose and cancer risk from airborne releases of plutonium. Nuclear safety technical report

    SciTech Connect (OSTI)

    Peterson, V.L.

    1993-12-23

    This report presents results of computations of doses and the associated health risks of postulated accidental atmospheric releases from the Rocky Flats Plant (RFP) of one gram of weapons-grade plutonium in a form that is respirable. These computations are intended to be reference computations that can be used to evaluate a variety of accident scenarios by scaling the dose and health risk results presented here according to the amount of plutonium postulated to be released, instead of repeating the computations for each scenario. The MACCS2 code has been used as the basis of these computations. The basis and capabilities of MACCS2 are summarized, the parameters used in the evaluations are discussed, and results are presented for the doses and health risks to the public, both the Maximum Offsite Individual (a maximally exposed individual at or beyond the plant boundaries) and the population within 50 miles of RFP. A number of different weather scenarios are evaluated, including constant weather conditions and observed weather for 1990, 1991, and 1992. The isotopic mix of weapons-grade plutonium will change as it ages, the {sup 241}Pu decaying into {sup 241}Am. The {sup 241}Am reaches a peak concentration after about 72 years. The doses to the bone surface, liver, and whole body will increase slightly but the dose to the lungs will decrease slightly. The overall cancer risk will show almost no change over this period. This change in cancer risk is much smaller than the year-to-year variations in cancer risk due to weather. Finally, x/Q values are also presented for other applications, such as for hazardous chemical releases. These include the x/Q values for the MOI, for a collocated worker at 100 meters downwind of an accident site, and the x/Q value integrated over the population out to 50 miles.

  14. Establishment of a bioassay system for cancer risk assessment in energy technology

    SciTech Connect (OSTI)

    Ts'o, P.O.P.; Bruce, S.A.; Brown, A. (eds.)

    1983-09-01

    Separate abstracts were prepared for 20 papers in this report. For several years the Department of Energy (DOE), Office of Health and Environmental Research (OHER), has supported a research program aimed at developing new experimental approaches for the improvement of cancer risk assessments. The central issue is to overcome the organizational, species and other barriers that make it difficult to extrapolate laboratory-based data to predict risk to man. Most of the participants at the meeting are involved in research aimed at understanding the mechanism(s) of chemical carcinogenesis. Complex mixtures of chemicals are associated with many energy technologies. DOE's initial program emphasis focused on semi-applied research aimed at quantitative evaluation of carcinogenic activity of complex materials. Since much progress has been made in DOE integrated technology-specific chemical-biological characterization studies, the number and kinds of chemicals of concern has been reduced to a relatively few well-defined classes. Although the classes of compounds seem to be unique to some of the synfuel technologies, they are quite similar to compounds of general interest, for example, poly-nuclear aromatic hydrocarbons. Special emphasis was placed on molecular and cellular dosimetry as one of the key requirements for quantitative comparison of effects at the cell level in vivo and in vitro. Although it is relatively easy to measure cell, tissue, organ and whole organism doses associated with radiation exposures, we are just learning how to do this for chemical agents. Several methods have been developed in the past several years which can be used.

  15. Secondary Malignancies From Prostate Cancer Radiation Treatment: A Risk Analysis of the Influence of Target Margins and Fractionation Patterns

    SciTech Connect (OSTI)

    Dasu, Alexandru; Toma-Dasu, Iuliana; Franzen, Lars; Widmark, Anders; Nilsson, Per

    2011-03-01

    Purpose: This study explores the implications for cancer induction of treatment details such as fractionation, planning target volume (PTV) definition, and interpatient variations, which are relevant for the radiation treatment of prostate carcinomas. Methods and Materials: Treatment planning data from 100 patients have been analyzed with a risk model based on the United Nations Scientific Committee on the Effects of Atomic Radiation competition model. The risk model can account for dose heterogeneity and fractionation effects characteristic for modern radiotherapy. Biologically relevant parameters from clinical and experimental data have been used with the model. Results: The results suggested that changes in prescribed dose could lead to a modification of the risks for individual organs surrounding the clinical target volume (CTV) but that the total risk appears to be less affected by changes in the target dose. Larger differences are observed for modifications of the margins between the CTV and the PTV because these have direct impact onto the dose level and dose heterogeneity in the healthy tissues surrounding the CTV. Interpatient anatomic variations also have to be taken into consideration for studies of the risk for cancer induction from radiotherapy. Conclusions: The results have shown the complex interplay between the risk for secondary malignancies, the details of the treatment delivery, and the patient heterogeneity that may influence comparisons between the long-term effects of various treatment techniques. Nevertheless, absolute risk levels seem very small and comparable to mortality risks from surgical interventions, thus supporting the robustness of radiation therapy as a successful treatment modality for prostate carcinomas.

  16. Stereotactic body radiotherapy for low-risk prostate cancer: five-year outcomes

    E-Print Network [OSTI]

    Freeman, Debra E; King, Christopher R

    2011-01-01

    GS: High dose rate brachytherapy as prostate cancerDose-Rate Prostate Brachytherapy: An Excellent Accelerated-Inoue T: High-dose-rate brachytherapy without external beam

  17. Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men

    E-Print Network [OSTI]

    2010-01-01

    older men Christine M. Barnett • Carrie M. Nielson • JackieD Á Prostate cancer C. M. Barnett Á T. M. Beer (&) Division

  18. Measurement of charm meson lifetimes

    E-Print Network [OSTI]

    Ammar, Raymond G.; Baringer, Philip S.; Bean, Alice; Besson, David Zeke; Coppage, Don; Davis, Robin E. P.; Kravchenko, I.; Kwak, Nowhan; Zhao, L.

    1999-06-01

    We report measurements of the D-0, D-,(+) and D-s(+) meson lifetimes using 3.7 fb(-1) of e(+)e(-) annihilation data collected near the Y(4S) resonance with the CLEO detector. The measured lifetimes of the D-0, D+, and D-s(+) mesons are 408.5 +/- 4.1(-3.4)(+3.5...

  19. Candidate locus analysis of the TERT–CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk

    E-Print Network [OSTI]

    Carvajal-Carmona, Luis G.; O’Mara, Tracy A.; Painter, Jodie N.; Lose, Felicity A.; Dennis, Joe; Michailidou, Kyriaki; Tyrer, Jonathan P.; Ahmed, Shahana; Ferguson, Kaltin; Healey, Catherine S.; Pooley, Karen; Beesley, Jonathan; Cheng, Timothy; Jones, Angela; Howarth, Kimberley; Martin, Lynn; Gorman, Maggie; Hodgson, Shirley; National Study of Endometrial Cancer Genetics Group (NSECG); The Australian National Endometrial Cancer Study Group (ANECS); Wentzensen, Nicholas; Fasching, Peter A.; Hein, Alexander; Beckmann, Matthias W.; Renner, Stefan P.; Dörk, Thilo; Hillemanns, Peter; Dürst, Matthias; Runnebaum, Ingo; Lambrechts, Diether; Coenegrachts, Lieve; Schrauwen, Stefanie; Amant, Frederic; Winterhoff, Boris; Dowdy, Sean C.; Goode, Ellen L.; Teoman, Attila; Salvesen, Helga B.; Trovik, Jone; Njolstad, Tormund S.; Werner, Henrica M. J.; Scott, Rodney J.; Ashton, Katie; Proietto, Tony; Otton, Geoffrey; Tzortzatos, Gerasimos; Mints, Miriam; Tham, Emma; RENDOCAS; Hall, Per; Czene, Kamila; Liu, Jianjun; Li, Jingmei; Hopper, John L.; Southey, Melissa C.; Australian Ovarian Cancer Study (AOCS); Ekici, Arif B.; Ruebner, Matthias; Johnson, Nichola; Peto, Julian; Burwinkel, Barbara; Marme, Frederik; Brenner, Hermann; Dieffenbach, Aida K.; Meindl, Alfons; Brauch, Hiltrud; The GENICA Network; Lindblom, Annika; Depreeuw, Jeroen; Moisse, Matthieu; Chang-Claude, Jenny; Rudolph, Anja; Couch, Fergus J.; Olson, Janet E.; Giles, Graham G.; Bruinsma, Fiona; Cunningham, Julie M.; Fridley, Brooke L.; Břrresen-Dale, Anne-Lise; Kristensen, Vessela N.; Cox, Angela; Swerdlow, Anthony; Orr, Nicholas; Bolla, Manjeet K.; Wang, Qin; Weber, Rachel Palmieri; Chen, Zhihua; Shah, Mitul; Pharoah, Paul D. P.; Dunning, Alison M.; Tomlinson, Ian; Easton, Douglas F.; Spurdle, Amanda B.; Thompson, Deborah J.

    2014-12-09

    , Sweden J. Liu · J. Li Human Genetics, Genome Institute of Singapore, Singapore, Singapore J. L. Hopper · G. G. Giles Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne... 2010 release of the 1000 Genomes Project (2012). These included all known SNPs with MAF >0.02 in Europeans and r2 > 0.1 with the then-known cancer-associated SNPs [rs402710 (McKay et al. 2008)] and/or rs3816659 (Shen et al. 2010), plus a tagging set...

  20. Pre-counseling Education for Low Literacy Women at Risk of Hereditary Breast and Ovarian Cancer (HBOC): Patient Experiences Using the Cancer Risk Education Intervention Tool (CREdIT)

    E-Print Network [OSTI]

    2010-01-01

    history of breast or ovarian cancer. JAMA, 293, Axilbund, J.131–136. Healthwise (2007) Ovarian cancer: Should I have myremoved to prevent ovarian cancer? Accessed January 14,

  1. Risk Factors for Regional Nodal Relapse in Breast Cancer Patients With One to Three Positive Axillary Nodes

    SciTech Connect (OSTI)

    Yates, Lucy; Kirby, Anna; Crichton, Siobhan; Gillett, Cheryl; Cane, Paul; Fentiman, Ian; Sawyer, Elinor

    2012-04-01

    Purpose: In many centers, supraclavicular fossa radiotherapy (SCF RT) is not routinely offered to breast cancer patients with one to three positive lymph nodes. We aimed to identify a subgroup of these patients who are at high risk of supra or infraclavicular fossa relapse (SCFR) such that they can be offered SCFRT at the time of diagnosis to improve long term locoregional control. Methods and Materials: We performed a retrospective analysis of the pathological features of 1,065 cases of invasive breast cancer with one to three positive axillary lymph nodes. Patients underwent radical breast conserving surgery or mastectomy. A total of 45% of patients received adjuvant chest wall/breast RT. No patients received adjuvant SCFRT. The primary outcome was SCFR. Secondary outcomes were chest wall/breast recurrence, distant metastasis, all death, and breast-cancer specific death. Kaplan-Meier estimates were used to calculate actuarial event rates and survival functions compared using log-rank tests. Multivariate analyses (MVA) of factors associated with outcome were conducted using Cox proportional hazards models. Results: Median follow-up was 9.7 years. SCFR rate was 9.2%. Median time from primary diagnosis to SCFR was 3.4 years (range, 0.7-14.4 years). SCFR was associated with significantly lower 10-year survival (18% vs. 65%; p < 0.001). Higher grade and number of positive lymph nodes were the most significant predictors of SCFR on MVA (p < 0.001). 10 year SCFR rates were less than 1% in all patients with Grade 1 cancers compared with 30% in those having Grade 3 cancers with three positive lymph nodes. Additional factors associated with SCFR on univariate analysis but not on MVA included larger nodal deposits (p = 0.002) and proportion of positive nodes (p = 0.003). Conclusions: Breast cancer patients with one to three positive lymph nodes have a heterogenous risk of SCFR. Patients with two to three positive axillary nodes and/or high-grade disease may warrant consideration of SCFRT.

  2. Urinary arsenic profiles and the risks of cancer mortality: A population-based 20-year follow-up study in arseniasis-endemic areas in Taiwan

    SciTech Connect (OSTI)

    Chung, Chi-Jung; Department of Medical Research, China Medical Hospital, Taichung, Taiwan ; Huang, Ya-Li; Huang, Yung-Kai; Wu, Meei-Maan; Chen, Shu-Yuan; Hsueh, Yu-Mei; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan ; Chen, Chien-Jen

    2013-04-15

    Few studies investigated the association between chronic arsenic exposure and the mortality of cancers by estimating individual urinary arsenic methylation profiles. Therefore, we compared with the general population in Taiwan to calculate the standardized mortality ratio (SMR) in arseniasis-endemic area of Taiwan from 1996 to 2010 and evaluated the dose-response relationships between environmental arsenic exposure indices or urinary arsenic profiles and the mortality of cause-specific cancer. A cohort of 1563 residents was conducted and collected their urine sample and information regarding arsenic exposure from a questionnaire. All-cause death was identified using the National Death Registry of Taiwan. Urinary arsenic profiles were measured using high performance liquid chromatography–hydride generator–atomic absorption spectrometry. We used Cox proportional hazard models to evaluate the mortality risks. In results, 193 all-site cancer deaths, and 29, 71, 43 deaths respectively for liver, lung and bladder cancers were ascertained. The SMRs were significantly high in arseniasis-endemic areas for liver, lung, and bladder cancers. People with high urinary InAs% or low DMA% or low secondary methylation index (SMI) were the most likely to suffer bladder cancer after adjusting other risk factors. Even stopping exposure to arsenic from the artesian well water, the mortality rates of the residents were higher than general population. Finally, urinary InAs%, DMA% and SMI could be the potential biomarkers to predict the mortality risk of bladder cancer. -- Highlights: ? The SMRs were significantly high in arseniasis-endemic areas for liver, lung, and bladder cancers. ? People with high urinary InAs% were the most likely to suffer bladder cancer. ? People with low DMA% or low SMI were the most likely to suffer bladder cancer.

  3. Parity and breast cancer risk among BRCA1and BRCA2mutation carriers

    E-Print Network [OSTI]

    Antoniou, Antonis C.; Shenton, Andrew; Maher, Eamonn R.; Watson, Emma; Woodward, Emma; Lalloo, Fiona; Easton, Douglas F.; Evans, D. Gareth

    2006-12-22

    this possible bias by including infor- mation on reproductive history on all known carriers, including those who are obligate carriers or who have died from a rele- vant cancer. However, the possibility of selection bias cannot be ruled out. Population...

  4. Competing-Risks Mortality After Radiotherapy vs. Observation for Localized Prostate Cancer: A Population-based Study

    SciTech Connect (OSTI)

    Abdollah, Firas; Department of Urology, Vita Salute San Raffaele University, Milan ; Sun, Maxine; Schmitges, Jan; Martini-Clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg ; Thuret, Rodolphe; Department of Urology, University of Montpellier Health Centre, Montpellier ; Tian, Zhe; Shariat, Shahrokh F.; Briganti, Alberto; Jeldres, Claudio; Perrotte, Paul; Department of Urology, University of Montreal Health Centre, Montreal ; Montorsi, Francesco; Karakiewicz, Pierre I.; Department of Urology, University of Montreal Health Centre, Montreal

    2012-09-01

    Purpose: Contemporary patients with localized prostate cancer (PCa) are more frequently treated with radiotherapy. However, there are limited data on the effect of this treatment on cancer-specific mortality (CSM). Our objective was to test the relationship between radiotherapy and survival in men with localized PCa and compare it with those treated with observation. Methods: A population-based cohort identified 68,797 men with cT1-T2 PCa treated with radiotherapy or observation between the years 1992 and 2005. Propensity-score matching was used to minimize potential bias related to treatment assignment. Competing-risks analyses tested the effect of treatment type (radiotherapy vs. observation) on CSM, after accounting to other-cause mortality. All analyses were carried out within PCa risk, baseline comorbidity status, and age groups. Results: Radiotherapy was associated with more favorable 10-year CSM rates than observation in patients with high-risk PCa (8.8 vs. 14.4%, hazard ratio [HR]: 0.59, 95% confidence interval [CI]: 0.50-0.68). Conversely, the beneficial effect of radiotherapy on CSM was not evident in patients with low-intermediate risk PCa (3.7 vs. 4.1%, HR: 0.91, 95% CI: 0.80-1.04). Radiotherapy was beneficial in elderly patients (5.6 vs. 7.3%, HR: 0.70, 95% CI: 0.59-0.80). Moreover, it was associated with improved CSM rates among patients with no comorbidities (5.7 vs. 6.5%, HR: 0.81, 95% CI: 0.67-0.98), one comorbidity (4.6 vs. 6.0%, HR: 0.87, 95% CI: 0.75-0.99), and more than two comorbidities (4.2 vs. 5.0%, HR: 0.79, 95% CI: 0.65-0.96). Conclusions: Radiotherapy substantially improves CSM in patients with high-risk PCa, with little or no benefit in patients with low-/intermediate-risk PCa relative to observation. These findings must be interpreted within the context of the limitations of observational data.

  5. Lymphedema in Breast Cancer Survivors : : Risk Factors, Distress and Quality of Life, and Patient Compliance with a Physician Referral

    E-Print Network [OSTI]

    Dominick, Sally Ann

    11 to 20 nodes ? 21 nodes Breast Cancer Surgery Lumpectomy/Mastectomies Time since Breast Cancer Surgery, yearsKahn KL. Arm edema in breast cancer patients. J Natl Cancer

  6. EPA Radiogenic Cancer Risk Models and Projections for the U.S. Population

    E-Print Network [OSTI]

    -LET Risks to Low Doses and Low Dose Rates .................................................. 15 2.1.5 Low ............................................................... 18 3. EPA Risk Projections for Low-LET Radiation ............................... 21 3.1 Introduction in Projections of LAR for Low-LET Radiation .............. 59 4.1 Introduction

  7. The Lifetime of Grand Design

    E-Print Network [OSTI]

    M. R. Merrifield; R. J. Rand; S. E. Meidt

    2005-11-02

    The lifetime of the structure in grand design spiral galaxies is observationally ill-determined, but is essentially set by how accurately the pattern's rotation can be characterized by a single angular pattern speed. This paper derives a generalized version of the Tremaine-Weinberg method for observationally determining pattern speeds, in which the pattern speed is allowed to vary arbitrarily with radius. The departures of the derived pattern speed from a constant then provides a simple metric of the lifetime of the spiral structure. Application of this method to CO observations of NGC 1068 reveal that the pattern speed of the spiral structure in this galaxy varies rapidly with radius, and that the lifetime of the spiral structure is correspondingly very short. If this result turns out to be common in grand-design spiral galaxies, then these features will have to be viewed as highly transient phenomena.

  8. Biochemical Control With Radiotherapy Improves Overall Survival in Intermediate and High-Risk Prostate Cancer Patients Who Have an Estimated 10-Year Overall Survival of >90%

    SciTech Connect (OSTI)

    Herbert, Christopher; Liu, Mitchell; Tyldesley, Scott; Morris, W. James; Joffres, Michel; Khaira, Mandip; Kwan, Winkle; Moiseenko, Vitali; Pickles, Thomas

    2012-05-01

    Purpose: To identify subgroups of patients with carcinoma of the prostate treated with radical radiotherapy that have improved overall survival when disease is biochemically controlled. Methods and Materials: A cohort of 1,060 prostate cancer patients treated with radical radiotherapy was divided into nine subgroups based on National Comprehensive Cancer Network risk category and estimated 10-year overall survival (eOS 10y) derived from the age adjusted Charlson Comorbidity Index. Patients with and without biochemical control were compared with respect to overall survival. Actuarial estimates of overall survival were calculated using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazards models were used for analysis of overall survival. Results: Median follow-up was 125 months (range, 51-176 months). Only the subgroups with high or intermediate risk disease and an eOS 10y of >90% had a statistically significantly improved overall survival when prostate cancer was biochemically controlled. In all other groups, biochemical control made no significant difference to overall survival. In the subgroup with high-risk disease and eOS 10y >90%, actuarial overall survival was 86.3% (95% confidence interval [CI] 78.5%-94.1%) and 62.1% (95% CI 52.9%-71.3%) for patients with biochemical control and biochemical relapse respectively (p = 0.002). In the intermediate risk group with eOS >90%, actuarial overall survival was 95.3% (95% CI 89.0%-100%) and 79.8% (95% CI 68.0%-91.6%) for biochemically controlled and biochemically relapsed patients (p = 0.033). On multivariate analysis, National Comprehensive Cancer Network risk group (p = 0.005), biochemical control (p = 0.033) and eOS 10y (p < 0.001) were statistically significant. Conclusion: Biochemical control translates into improved overall survival in patients with high or intermediate risk disease and an estimated 10-year overall survival of >90%.

  9. Evidence That New Hypnotics Cause Cancer

    E-Print Network [OSTI]

    Kripke, Daniel F.

    2008-01-01

    medication use and risk of epithelial ovarian cancer.Cancer Epidemiol. Biomarkers Prev. , Hays, J. C. , Blazer,the likelihood of cancer causation is sufficiently strong

  10. Pegfilgrastim prophylaxis is associated with a lower risk of hospitalization of cancer patients than filgrastim prophylaxis: a retrospective United States claims analysis of granulocyte colony-stimulating factors (G-CSF)

    E-Print Network [OSTI]

    2013-01-01

    cancer, lung cancer, ovarian cancer, or colorectal cancer.cancer, lung cancer, ovarian cancer, or colorectal cancerlung cancer, NHL, ovarian cancer, or colorectal cancer

  11. Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma

    SciTech Connect (OSTI)

    Radi, Zaher; Bartholomew, Phillip; Elwell, Michael; Vogel, W. Mark

    2013-12-15

    In humans, hibernoma is a very rare, benign neoplasm of brown adipose tissue (BAT) that typically occurs at subcutaneous locations and is successfully treated by surgical excision. No single cause has been accepted to explain these very rare human tumors. In contrast, spontaneous hibernoma in rats is rare, often malignant, usually occurs in the thoracic or abdominal cavity, and metastases are common. In recent years, there has been an increased incidence of spontaneous hibernomas in rat carcinogenicity studies, but overall the occurrence remains relatively low and highly variable across studies. There have only been four reported examples of pharmaceutical-induced hibernoma in rat carcinogenicity studies. These include phentolamine, an alpha-adrenergic antagonist; varenicline, a nicotine partial agonist; tofacitinib, a Janus kinase (JAK) inhibitor; and hydromorphone, an opiod analgesic. Potential non-genotoxic mechanisms that may contribute to the pathogenesis of BAT activation/proliferation and/or subsequent hibernoma development in rats include: (1) physiological stimuli, (2) sympathetic stimulation, (3) peroxisome proliferator-activated receptor (PPAR) agonism, and/or (4) interference or inhibition of JAK/Signal Transducer and Activator of Transcription (JAK/STAT) signaling. The evaluation of an apparent increase of hibernoma in rats from 2-year carcinogenicity studies of novel pharmaceutical therapeutics and its relevance to human safety risk assessment is complex. One should consider: the genotoxicity of the test article, dose/exposure and safety margins, and pathophysiologic and morphologic differences and similarities of hibernoma between rats and humans. Hibernomas observed to date in carcinogenicity studies of pharmaceutical agents do not appear to be relevant for human risk at therapeutic dosages. - Highlights: • Highly variable incidence of spontaneous hibernoma in carcinogenicity studies • Recent increase in the spontaneous incidence of hibernomas in Sprague–Dawley rats • Pharmaceutical-related hibernoma has been observed in rats, but not in humans. • Pathophysiologic and morphologic differences of hibernoma between rats and 7 humans. • Hibernomas are unlikely to be relevant to human risk assessment.

  12. Technical challenges of sparing infrahyoid swallowing organs at risk in oropharynx squamous cell cancer treated with IMRT

    SciTech Connect (OSTI)

    Morley, Lyndon; Tsang, Shirley W.S.; Breen, Stephen L.; Waldron, John N.; Maganti, Manjula; Pintilie, Melania; Dawson, Laura A.; Ringash, Jolie; Huang, Shao Hui; Kim, John

    2014-07-01

    This study reports clinical performance in the sparing of infrahyoid swallowing organs at risk (SWOARs) in oropharynx cancer intensity-modulated radiation therapy (IMRT) plans. Rates of meeting dose-volume planning goals are reported and compared with geometry-based estimates of what is achievable. This study also develops 3 measures of target-SWOAR geometry and tests their usefulness in providing geometry-based dose-volume planning goals. A total of 50 oropharynx cancer IMRT plans were reviewed. Success rates in meeting institutional dose-volume goals were determined for the glottic larynx (G), postcricoid pharynx (P), and esophagus (E). The following 3 measures of target-SWOAR geometry were investigated as methods of identifying geometry-based planning goals: presence of gross disease in neck levels 3 to 4, target-SWOAR overlap, and a 3-dimensional (3D) measure of target-SWOAR geometry. Locally advanced disease was predominant in this patient population with target volumes overlapping SWOARs in 68% to 98% of cases. Clinical rates of success in meeting dose-volume goals varied by SWOAR (16% to 82%) but compared well with estimated potentially achievable rates in most cases (14% average difference between clinical and potential). Cases grouped by the presence of levels 3 to 4 neck nodes or target-SWOAR overlap did not have significantly different SWOAR doses. Cases grouped using a 3D measure of target-SWOAR geometry differed significantly, providing useful geometry-based planning goals (e.g., mean Glottis dose <45 Gy was achieved 19%, 44%, or 81% of the time in each of 3 groups). This study describes the technical challenge of sparing SWOARs and investigates several potential methods for grouping cases to assist with treatment plan evaluation. Quantifying the 3-D relationship between the targets and SWOARs is a promising way of approaching this complex problem. Data presented in this paper may be useful to evaluate treatment plans using objective geometry-based goals.

  13. Quantification of Contralateral Breast Dose and Risk Estimate of Radiation-Induced Contralateral Breast Cancer Among Young Women Using Tangential Fields and Different Modes of Breathing

    SciTech Connect (OSTI)

    Zurl, Brigitte; Stranzl, Heidi; Winkler, Peter; Kapp, Karin Sigrid

    2013-02-01

    Purpose: Whole breast irradiation with deep-inspiration breath-hold (DIBH) technique among left-sided breast cancer patients significantly reduces cardiac irradiation; however, a potential disadvantage is increased incidental irradiation of the contralateral breast. Methods and Materials: Contralateral breast dose (CBD) was calculated by comparing 400 treatment plans of 200 left-sided breast cancer patients whose tangential fields had been planned on gated and nongated CT data sets. Various anatomic and field parameters were analyzed for their impact on CBD. For a subgroup of patients (aged {<=}45 years) second cancer risk in the contralateral breast (CB) was modeled by applying the linear quadratic model, compound models, and compound models considering dose-volume information (DVH). Results: The mean CBD was significantly higher in DIBH with 0.69 Gy compared with 0.65 Gy in normal breathing (P=.01). The greatest impact on CBD was due to a shift of the inner field margin toward the CB in DIBH (mean 0.4 cm; range, 0-2), followed by field size in magnitude. Calculation with different risk models for CBC revealed values of excess relative risk/Gy ranging from 0.48-0.65 vs 0.46-0.61 for DIBH vs normal breathing, respectively. Conclusion: Contralateral breast dose, although within a low dose range, was mildly but significantly increased in 200 treatment plans generated under gated conditions, predominately due to a shift in the medial field margin. Risk modeling for CBC among women aged {<=}45 years also pointed to a higher risk when comparing DIBH with normal breathing. This risk, however, was substantially lower in the model considering DVH information. We think that clinical decisions should not be affected by this small increase in CBD with DIBH because DIBH is effective in reducing the dose to the heart in all patients.

  14. Acute Toxicity in High-Risk Prostate Cancer Patients Treated With Androgen Suppression and Hypofractionated Intensity-Modulated Radiotherapy

    SciTech Connect (OSTI)

    Pervez, Nadeem, E-mail: nadeempe@cancerboard.ab.c [Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); Small, Cormac [Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); MacKenzie, Marc [Division of Medical Physics, Cross Cancer Institute, Edmonton, Alberta (Canada); Yee, Don; Parliament, Matthew [Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); Ghosh, Sunita [Division of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); Mihai, Alina; Amanie, John; Murtha, Albert [Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); Field, Colin [Division of Medical Physics, Cross Cancer Institute, Edmonton, Alberta (Canada); Murray, David [Division of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); Fallone, Gino [Division of Medical Physics, Cross Cancer Institute, Edmonton, Alberta (Canada); Pearcey, Robert, E-mail: robertpe@cancerboard.ab.c [Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada)

    2010-01-15

    Purpose: To report acute toxicity resulting from radiotherapy (RT) dose escalation and hypofractionation using intensity-modulated RT (IMRT) treatment combined with androgen suppression in high-risk prostate cancer patients. Methods and Materials: Sixty patients with a histological diagnosis of high-risk prostatic adenocarcinoma (having either a clinical Stage of >=T3a or an initial prostate-specific antigen [PSA] level of >=20 ng/ml or a Gleason score of 8 to 10 or a combination of a PSA concentration of >15 ng/ml and a Gleason score of 7) were enrolled. RT prescription was 68 Gy in 25 fractions (2.72 Gy/fraction) over 5 weeks to the prostate and proximal seminal vesicles. The pelvic lymph nodes and distal seminal vesicles concurrently received 45 Gy in 25 fractions. The patients were treated with helical TomoTherapy-based IMRT and underwent daily megavoltage CT image-guided verification prior to each treatment. Acute toxicity scores were recorded weekly during RT and at 3 months post-RT, using Radiation Therapy Oncology Group acute toxicity scales. Results: All patients completed RT and follow up for 3 months. The maximum acute toxicity scores were as follows: 21 (35%) patients had Grade 2 gastrointestinal (GI) toxicity; 4 (6.67%) patients had Grade 3 genitourinary (GU) toxicity; and 30 (33.33%) patients had Grade 2 GU toxicity. These toxicity scores were reduced after RT; there were only 8 (13.6%) patients with Grade 1 GI toxicity, 11 (18.97%) with Grade 1 GU toxicity, and 5 (8.62%) with Grade 2 GU toxicity at 3 months follow up. Only the V60 to the rectum correlated with the GI toxicity. Conclusion: Dose escalation using a hypofractionated schedule to the prostate with concurrent pelvic lymph node RT and long-term androgen suppression therapy is well tolerated acutely. Longer follow up for outcome and late toxicity is required.

  15. Clinical Application of High-Dose, Image-Guided Intensity-Modulated Radiotherapy in High-Risk Prostate Cancer

    SciTech Connect (OSTI)

    Bayley, Andrew, E-mail: Andrew.Bayley@rmp.uhn.on.c [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada) and Department of Radiation Oncology, University of Toronto, Toronto, ON (Canada); Rosewall, Tara; Craig, Tim; Bristow, Rob; Chung, Peter; Gospodarowicz, Mary; Menard, Cynthia; Milosevic, Michael; Warde, Padraig; Catton, Charles [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada) and Department of Radiation Oncology, University of Toronto, Toronto, ON (Canada)

    2010-06-01

    Purpose: To report the feasibility and early toxicity of dose-escalated image-guided IMRT to the pelvic lymph nodes (LN), prostate (P), and seminal vesicles (SV). Methods and Materials: A total of 103 high-risk prostate cancer patients received two-phase, dose-escalated, image-guided IMRT with 3 years of androgen deprivation therapy. Clinical target volumes (CTVs) were delineated using computed tomography/magnetic resonance co-registration and included the prostate, portions of the SV, and the LN. Planning target volume margins (PTV) used were as follows: P (10 mm, 7 mm posteriorly), SV (10 mm), and LN (5 mm). Organs at risk (OaR) were the rectal and bladder walls, femoral heads, and large and small bowel. The IMRT was planned with an intended dose of 55.1 Gy in 29 fractions to all CTVs (Phase 1), with P+SV consecutive boost of 24.7 Gy in 13 fractions. Daily online image guidance was performed using bony landmarks and intraprostatic markers. Feasibility criteria included delivery of intended doses in 80% of patients, 95% of CTV displacements incorporated within PTV during Phase 1, and acute toxicity rate comparable to that of lower-dose pelvic techniques. Results: A total of 91 patients (88%) received the total prescription dose. All patients received at least 72 Gy. In Phase 1, 63 patients (61%) received the intended 55.1 Gy, whereas 87% of patients received at least 50 Gy. Dose reductions were caused by small bowel and rectal wall constraints. All CTVs received the planned dose in >95% of treatment fractions. There were no Radiation Therapy Oncology Group acute toxicities greater than Grade 3, although there were five incidences equivalent to Grade 3 within a median follow-up of 23 months. Conclusion: These results suggest that dose escalation to the PLN+P+SV using IMRT is feasible, with acceptable rates of acute toxicity.

  16. PSA Response to Neoadjuvant Androgen Deprivation Therapy Is a Strong Independent Predictor of Survival in High-Risk Prostate Cancer in the Dose-Escalated Radiation Therapy Era

    SciTech Connect (OSTI)

    McGuire, Sean E.; Lee, Andrew K.; Cerne, Jasmina Z.; Munsell, Mark F.; Levy, Lawrence B.; Kudchadker, Rajat J.; Choi, Seungtaek L.; Nguyen, Quynh N.; Hoffman, Karen E.; Pugh, Thomas J.; Frank, Steven J.; Corn, Paul G.; Logothetis, Christopher J.; Kuban, Deborah A.

    2013-01-01

    Purpose: The aim of the study was to evaluate the prognostic value of prostate-specific antigen (PSA) response to neoadjuvant androgen deprivation therapy (ADT) prior to dose-escalated radiation therapy (RT) and long-term ADT in high-risk prostate cancer. Methods and Materials: We reviewed the charts of all patients diagnosed with high-risk prostate cancer and treated with a combination of long-term ADT (median, 24 months) and dose-escalated (median, 75.6 Gy) RT between 1990 and 2007. The associations among patient, tumor, and treatment characteristics with biochemical response to neoadjuvant ADT and their effects on failure-free survival (FFS), time to distant metastasis (TDM), prostate cancer-specific mortality (PCSM) and overall survival (OS) were examined. Results: A total of 196 patients met criteria for inclusion. Median follow-up time for patients alive at last contact was 7.0 years (range, 0.5-18.1 years). Multivariate analysis identified the pre-RT PSA concentration (<0.5 vs {>=}0.5 ng/mL) as a significant independent predictor of FFS (P=.021), TDM (P=.009), PCSM (P=.039), and OS (P=.037). On multivariate analysis, pretreatment PSA (iPSA) and African-American race were significantly associated with failure to achieve a pre-RT PSA of <0.5 ng/mL. Conclusions: For high-risk prostate cancer patients treated with long-term ADT and dose-escalated RT, a pre-RT PSA level {>=}0.5 ng/mL after neoadjuvant ADT predicts for worse survival measures. Both elevated iPSA and African-American race are associated with increased risk of having a pre-RT PSA level {>=}0.5 ng/mL. These patients should be considered for clinical trials that test newer, more potent androgen-depleting therapies such as abiraterone and MDV3100 in combination with radiation.

  17. LONG-CHAIN POLYUNSATURATED FATTY ACID INTAKE AND ITS RELATIONSHIP TO RED BLOOD CELL AND SERUM LONG-CHAIN POLYUNSATURATED FATTY ACIDS IN WOMEN AT HIGH RISK FOR BREAST CANCER

    E-Print Network [OSTI]

    Harvey, Katherine

    2010-04-27

    A higher ratio of omega-6 (n-6) to omega-3 (n-3) long chain polyunsaturated fatty acids (LCPUFA) in breast tissue triglyceride (TG) has been correlated with increased risk of developing breast cancer. Before dietary recommendations can be made...

  18. USING RISK-BASED CORRECTIVE ACTION (RBCA) TO ASSESS (THEORETICAL) CANCER DEATHS AVERTED COMPARED TO THE (REAL) COST OF ENVIRONMENTAL REMEDIATION

    SciTech Connect (OSTI)

    Miller, M. L.; Hylko, J. M.

    2002-02-25

    In 1978, on the basis of existing health studies at the time, the Uranium Mill Tailings Remedial Action (UMTRA) Project legislation was proposed that would authorize remedial action at inactive uranium processing sites and vicinity properties. The cost of the program to the Federal Government was expected to be $180 million. With the completion of this project, approximately 1300 theoretical cancer deaths were prevented in the next 100 years at a cost of $1.45 billion, based on the Fiscal Year 1998 Federal UMTRA budget. The individual site costs ranged from $0.2 million up to $18 billion spent per theoretical cancer death averted over the next 100 years. Resources required to sustain remediation activities such as this are subject to reduction over time, and are originally based on conservative assumptions that tend to overestimate risks to the general public. This evaluation used a process incorporating risk-based corrective action (RBCA); a three-tiered, decision-making process tailoring corrective action activities according to site-specific conditions and risks. If RBCA had been applied at the start of the UMTRA Project, and using a criterion of >1 excess cancer death prevented as justification to remediate the site, only 50% of the existing sites would have been remediated, yielding a cost savings of $303.6 million to the Federal Government and affected States, which share 10% of the cost. This cost savings equates to 21% of the overall project budget. In addition, only 22% of the vicinity properties had structural contamination contributing to elevated interior gamma exposure and radon levels. Focusing only on these particular properties could have saved an additional $269.3 million, yielding a total savings of $573 million; 40% of the overall project budget. As operational experience is acquired, including greater understanding of the radiological and nonradiological risks, decisions should be based on the RBCA process, rather than relying on conservative assumptions that tend to overestimate risks to the general public.

  19. Retrospective Evaluation Reveals That Long-term Androgen Deprivation Therapy Improves Cause-Specific and Overall Survival in the Setting of Dose-Escalated Radiation for High-Risk Prostate Cancer

    SciTech Connect (OSTI)

    Feng, Felix Y.; Blas, Kevin; Olson, Karin; Stenmark, Matthew; Sandler, Howard; Hamstra, Daniel A.

    2013-05-01

    Purpose: To evaluate the role of androgen deprivation therapy (ADT) and duration for high-risk prostate cancer patients treated with dose-escalated radiation therapy (RT). Methods and Materials: A retrospective analysis of high-risk prostate cancer patients treated with dose-escalated RT (minimum 75 Gy) with or without ADT was performed. The relationship between ADT use and duration with biochemical failure (BF), metastatic failure (MF), prostate cancer-specific mortality (PCSM), non-prostate cancer death (NPCD), and overall survival (OS) was assessed as a function of pretreatment characteristics, comorbid medical illness, and treatment using Fine and Gray's cumulative incidence methodology. Results: The median follow-up time was 64 months. In men with National Comprehensive Cancer Network defined high-risk prostate cancer treated with dose-escalated RT, on univariate analysis, both metastasis (P<.0001; hazard ratio 0.34; 95% confidence interval 0.18-0.67; cumulative incidence at 60 months 13% vs 35%) and PCSM (P=.015; hazard ratio 0.41; 95% confidence interval 0.2-1.0; cumulative incidence at 60 months 6% vs 11%) were improved with the use of ADT. On multivariate analysis for all high-risk patients, Gleason score was the strongest negative prognostic factor, and long-term ADT (LTAD) improved MF (P=.002), PCSM (P=.034), and OS (P=.001). In men with prostate cancer and Gleason scores 8 to 10, on multivariate analysis after adjustment for other risk features, there was a duration-dependent improvement in BF, metastasis, PCSM, and OS, all favoring LTAD in comparison with STAD or RT alone. Conclusion: For men with high-risk prostate cancer treated with dose-escalated EBRT, this retrospective study suggests that the combination of LTAD and RT provided a significant improvement in clinical outcome, which was especially true for those with Gleason scores of 8 to 10.

  20. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

    E-Print Network [OSTI]

    2009-01-01

    breast cancer and ovarian cancers as compared with thedence of breast and ovarian cancers, even among women whoof breast cancer and/or ovarian cancer. The current study is

  1. Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the EPIC-Norfolk study

    E-Print Network [OSTI]

    Ward, Heather A; Chapelais, Gaelle; Kuhnle, Gunter G C; Luben, Robert; Khaw, Kay-Tee; Bingham, Sheila

    2008-04-17

    of breast cancer, but only a limited range of phytoestrogens has been examined in prospective cohort studies. Methods Serum and urine samples from 237 incident breast cancer cases and 952 control individuals (aged 45 to 75 years) in the European Prospective...

  2. Solutions 1 Part B Statistical Lifetime-Models Oxford HT 2015 I B.1 Lifetime distributions

    E-Print Network [OSTI]

    Winkel, Matthias

    withdrawal from service; lifetime of a lightbulb before burn-out; time a new employee spends at a firm before

  3. Drogue and Transmitter Lifetime Presented by

    E-Print Network [OSTI]

    sensors still "max out" and the GDP is waiting on strain gauge drifters to be deployed for evaluation. #12Drogue and Transmitter Lifetime Evaluation Presented by: Erik Valdes Drifter Data Assembly Center lifetime Evaluation All manufacturers except Pacific Gyre have changed to tether strain by early 2010

  4. Atmospheric Lifetime of Fossil Fuel Carbon Dioxide

    E-Print Network [OSTI]

    Atmospheric Lifetime of Fossil Fuel Carbon Dioxide David Archer,1 Michael Eby,2 Victor Brovkin,3 released from combustion of fossil fuels equilibrates among the various carbon reservoirs of the atmosphere literature on the atmospheric lifetime of fossil fuel CO2 and its impact on climate, and we present initial

  5. Is Biological Subtype Prognostic of Locoregional Recurrence Risk in Women With pT1-2N0 Breast Cancer Treated With Mastectomy?

    SciTech Connect (OSTI)

    Truong, Pauline T.; Sadek, Betro T.; Lesperance, Maria F.; Alexander, Cheryl S.; Shenouda, Mina; Raad, Rita Abi; Taghian, Alphonse G.

    2014-01-01

    Purpose: To examine locoregional and distant recurrence (LRR and DR) in women with pT1-2N0 breast cancer according to approximated subtype and clinicopathologic characteristics. Methods and Materials: Two independent datasets were pooled and analyzed. The study participants were 1994 patients with pT1-2N0M0 breast cancer, treated with mastectomy without radiation therapy. The patients were classified into 1 of 5 subtypes: luminal A (ER+ or PR+/HER 2?/grade 1-2, n=1202); luminal B (ER+ or PR+/HER 2?/grade 3, n=294); luminal HER 2 (ER+ or PR+/HER 2+, n=221); HER 2 (ER?/PR?/HER 2+, n=105) and triple-negative breast cancer (TNBC) (ER?/PR?/HER 2?, n=172). Results: The median follow-up time was 4.3 years. The 5-year Kaplan-Meier (KM) LRR were 1.8% in luminal A, 3.1% in luminal B, 1.7% in luminal HER 2, 1.9% in HER 2, and 1.9% in TNBC cohorts (P=.81). The 5-year KM DR was highest among women with TNBC: 1.8% in luminal A, 5.0% in luminal B, 2.4% in luminal HER 2, 1.1% in HER 2, and 9.6% in TNBC cohorts (P<.001). Among 172 women with TNBC, the 5-year KM LRR were 1.3% with clear margins versus 12.5% with close or positive margins (P=.04). On multivariable analysis, factors that conferred higher LRR risk were tumors >2 cm, lobular histology, and close/positive surgical margins. Conclusions: The 5-year risk of LRR in our pT1-2N0 cohort treated with mastectomy was generally low, with no significant differences observed between approximated subtypes. Among the subtypes, TNBC conferred the highest risk of DR and an elevated risk of LRR in the presence of positive or close margins. Our data suggest that although subtype alone cannot be used as the sole criterion to offer postmastectomy radiation therapy, it may reasonably be considered in conjunction with other clinicopathologic factors including tumor size, histology, and margin status. Larger cohorts and longer follow-up times are needed to define which women with node-negative disease have high postmastectomy LRR risks in contemporary practice.

  6. Functional Promoter Variant rs2868371 of HSPB1 Is Associated With Risk of Radiation Pneumonitis After Chemoradiation for Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Pang, Qingsong; Department of Radiation Oncology and Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin ; Wei, Qingyi; Xu, Ting; Yuan, Xianglin; Lopez Guerra, Jose Luis; Levy, Lawrence B.; Liu, Zhensheng; Gomez, Daniel R.; Zhuang, Yan; Wang, Li-E.; Mohan, Radhe; Komaki, Ritsuko; Liao, Zhongxing

    2013-04-01

    Purpose: To date, no biomarkers have been found to predict, before treatment, which patients will develop radiation pneumonitis (RP), a potentially fatal toxicity, after chemoradiation for lung cancer. We investigated potential associations between single nucleotide polymorphisms (SNPs) in HSPB1 and risk of RP after chemoradiation for non-small cell lung cancer (NSCLC). Methods and Materials: Subjects were patients with NSCLC treated with chemoradiation at 1 institution. The training data set comprised 146 patients treated from 1999 to July 2004; the validation data set was 125 patients treated from August 2004 to March 2010. We genotyped 2 functional SNPs of HSPB1 (rs2868370 and rs2868371) from all patients. We used Kaplan-Meier analysis to assess the risk of grade ?2 or ?3 RP in both data sets and a parametric log-logistic survival model to evaluate the association of HSPB1 genotypes with that risk. Results: Grade ?3 RP was experienced by 13% of those with CG/GG and 29% of those with CC genotype of HSPB1 rs2868371 in the training data set (P=.028); corresponding rates in the validation data set were 2% CG/GG and 14% CC (P=.02). Univariate and multivariate analysis confirmed the association of CC of HSPB1 rs2868371 with higher risk of grade ?3 RP than CG/GG after adjustment for sex, age, performance status, and lung mean dose. This association was validated both in the validation data set and with Harrell's C statistic. Conclusions: The CC genotype of HSPB1 rs2868371 was associated with severe RP after chemoradiation for NSCLC.

  7. Nervous system cancer : analysis of historical mortality rates in the United States and Japan indicate sudden increases in environmental risk

    E-Print Network [OSTI]

    Alhassani, Ali K

    2008-01-01

    Nervous System cancer age-specific mortality rates began being recorded for European and Non-European Americans in 1930 and for Japanese in 1952. All ethnic groups show significant historical increases in mortality rates. ...

  8. Health and environmental risks of energy systems

    SciTech Connect (OSTI)

    Hamilton, L.D.

    1984-01-01

    This paper gives four examples of health risk assessments of energy systems: (1) Comparative risk assessment of the health effects of the coal and nuclear fuel cycles. Estimates differ from previous values chiefly by inclusion of ranges of uncertainty, but some coal-cycle numbers were re-estimated. Upper-boundary public disease risks of air pollution from coal-fired plants dominate. Reactors probably account for most of the potential effect of major nuclear accidents. Accidental death rates in electricity generation are low for reactors and higher for coal. (2) Upper boundary air pollution health risks of existing fossil-based energy technologies in the United States. Preliminary mortality estimates were obtained combining potential impacts of three index pollutants - SO/sub 4/, NO/sub 2/, and CO - as independent measures of risk. Four fuel cycle trajectories leading to three end-uses were analyzed. Example results: domestic wood burning has substantial potential impact, with an upper boundary exceeding that of coal; upper-boundary air pollution impacts of gas can exceed those of oil, because of NO/sub 2/. (3) Health risks of acid deposition and other transported air pollutants, carried out as part of an assessment of the US Congress Office of Technology Assessment (OTA) Acid Rain and Transported Air Pollutants - Implications for Public Policy. Three scenarios were examined, leading to estimates of 40,000 to 50,000 annual premature deaths, depending on year (1978 vs 2000) and scenario (holding total emissions constant vs 30% reduction). (4) health effects of uranium mill tailings piles. Mortality risk is estimated to be minuscule (8.7 x 10/sup -9/ average individual lifetime cancer risk from a model mill, compared with 9.5 x 10/sup -4/ for background radiation). Methods that sum risks over the indefinite future are shown to be to be unrealistic. 39 references, 7 figures, 15 tables.

  9. A Phase I Trial of Samarium-153-Lexidronam Complex for Treatment of Clinically Nonmetastatic High-Risk Prostate Cancer: First Report of a Completed Study

    SciTech Connect (OSTI)

    Valicenti, Richard K., E-mail: richard.valicenti@ucdmc.ucdavis.ed [Department Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Trabulsi, Edouard [Department of Urology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States); Intenzo, Charles [Department of Radiology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States); Lavarino, Jorosali [Department Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Xu Yihuan; Chervoneva, Inna [Department of Pharmacology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States)

    2011-03-01

    Purpose: We completed a Phase I trial to determine the maximum tolerated dose of samarium-153 EDTMP ({sup 153}Sm) with hormonal therapy (HT) and radiation therapy (RT) in high-risk clinically nonmetastatic prostate cancer. Methods and Materials: High-risk M0 prostate cancer patients (prostate-specific antigen >20 ng/mL, Gleason score >7, or >T3) were eligible for this prospective trial of dose-escalated radioactive {sup 153}Sm-EDTMP (.25-2.0 mCi/kg) as primary or postoperative therapy. After 1 month of HT, we administered {sup 153}Sm-EDTMP followed by 4 more months of HT, 46.8 Gy to the pelvic region and 23.4 Gy to the prostate target (TD = 70.2 Gy). The primary endpoint was Grade III toxicity or higher by the National Cancer Institute Common Toxicity Criteria. Results: Twenty-nine patients enrolled (median prostate-specific antigen = 8.2 ng/mL, 27/29 (93%) T stage {>=}T2b, 24/29 (83%) had Gleason >7) and received {sup 153}Sm-EDTMP (.25 mCi/kg, 4 patients; 0.5 mCi/kg, 4 patients; 0.75 mCi/kg, 6 patients; 1.0 mCi/kg, 6 patients; 1.5 mCi/kg, 5 patients; 2.0mCi/kg, 4 patients). Twenty-eight patients underwent all planned therapy without delays (1 patient required surgery before the start of RT). With a median follow-up time of 23 months, there were 2 patients (7 %) experiencing Grade III hematologic toxicity. There were no other Grade III or IV side effects. Conclusions: Our trial demonstrates that 2 mCi/kg {sup 153}Sm -EDTMP with HT and RT was safe and feasible in men with high-risk M0 prostate cancer. A Phase II study to test this treatment is currently underway by the Radiation Therapy Oncology Group.

  10. Models for Battery Reliability and Lifetime

    SciTech Connect (OSTI)

    Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G. H.; Neubauer, J.; Pesaran, A.

    2014-03-01

    Models describing battery degradation physics are needed to more accurately understand how battery usage and next-generation battery designs can be optimized for performance and lifetime. Such lifetime models may also reduce the cost of battery aging experiments and shorten the time required to validate battery lifetime. Models for chemical degradation and mechanical stress are reviewed. Experimental analysis of aging data from a commercial iron-phosphate lithium-ion (Li-ion) cell elucidates the relative importance of several mechanical stress-induced degradation mechanisms.

  11. Polymer Electrolyte Fuel Cell Lifetime Limitations: The Role...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Electrolyte Fuel Cell Lifetime Limitations: The Role of Electrocatalyst Degradation Polymer Electrolyte Fuel Cell Lifetime Limitations: The Role of Electrocatalyst Degradation...

  12. Kidney cancer is one of the most common cancers occurring in 1-2% of individuals in their

    E-Print Network [OSTI]

    O'Hern, Corey S.

    Kidney cancer is one of the most common cancers occurring in 1-2% of individuals in their lifetime. The current incidence in the United States is approximately 60,000-cases/ year. While many cancers were believed to occur sporadically, it's now understood approximately 5-8% of kidney cancers have a genetic

  13. CHEST Supplement Screening for Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    e78S CHEST Supplement Screening for Lung Cancer DIAGNOSIS AND MANAGEMENT OF LUNG CANCER, 3RD ED individuals). 3.2.2. In patients at risk for developing lung cancer, screening for lung cancer with sputum are age 55 to 74 and who have smoked for Background: Lung cancer is by far the major cause of cancer

  14. Determination of the historical changes in primary and secondary risk factors for cancer using U.S. public health records

    E-Print Network [OSTI]

    Herrero Jimenez, Pablo, 1972-

    2001-01-01

    Overall cancer mortality rates have risen from about 4% of all deaths in the early 20th century to about 25% of all deaths by the end of the century in the United States. To assess any potential hypotheses for this increase ...

  15. EPA`s risk assessment guidelines: Overview

    SciTech Connect (OSTI)

    Patton, D.E.

    1990-12-31

    The US Environmental Protection Agency (EPA) risk assessment guidelines for cancer, quantification, and exposure issues are discussed.

  16. Factors Affecting the Risk of Brain Metastasis in Small Cell Lung Cancer With Surgery: Is Prophylactic Cranial Irradiation Necessary for Stage I-III Disease?

    SciTech Connect (OSTI)

    Gong Linlin; Wang, Q.I.; Zhao Lujun; Yuan Zhiyong; Li Ruijian; Wang Ping

    2013-01-01

    Purpose: The use of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) with surgical resection has not been fully identified. This study undertook to assess the factors affecting the risk of brain metastases in patients with stage I-III SCLC after surgical resection. The implications of PCI treatment for these patients are discussed. Methods and Materials: One hundred twenty-six patients treated with surgical resection for stage I-III SCLC from January 1998-December 2009 were retrospectively analyzed to elucidate the risk factors of brain metastases. Log-rank test and Cox regression model were used to determine the risk factors of brain metastases. Results: The median survival time for this patient population was 34 months, and the 5-year overall survival rate was 34.9%. For the whole group, 23.0% (29/126) of the patients had evidence of metastases to brain. Pathologic stage not only correlated with overall survival but also significantly affected the risk of brain metastases. The 5-year survival rates for patients with pathologic stages I, II, and III were 54.8%, 35.6%, and 14.1%, respectively (P=.001). The frequency of brain metastases in patients with pathologic stages I, II, and III were 6.25% (2/32), 28.2% (11/39), and 29.1% (16/55) (P=.026), respectively. A significant difference in brain metastases between patients with complete resection and incomplete resection was also observed (20.5% vs 42.9%, P=.028). The frequency of brain metastases was not found to be correlated with age, sex, pathologic type, induction chemotherapy, adjuvant chemotherapy, or adjuvant radiation therapy. Conclusions: Stage I SCLC patients with complete resection had a low incidence of brain metastases and a favorable survival rate. Stage II-III disease had a higher incidence of brain metastases. Thus, PCI might have a role for stage II-III disease but not for stage I disease.

  17. Early Lung Cancer Detection Program

    Broader source: Energy.gov [DOE]

    Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

  18. Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

    E-Print Network [OSTI]

    Ghoussaini, Maya; Edwards, Stacey L.; Michailidou, Kyriaki; Nord, Silje; Cowper-Sal•lari, Richard; Desai, Kinjal; Kar, Siddhartha; Hillman, Kristine M.; Kaufmann, Susanne; Glubb, Dylan M.; Beesley, Jonathan; Dennis, Joe; Bolla, Manjeet K.; Wang, Qin; Dicks, Ed; Guo, Qi; Schmidt, Marjanka K.; Shah, Mitul; Luben, Robert; Brown, Judith; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Daniel, Klevebring; Bojesen, Stig E.; Nordestgaard, Břrge G.; Nielsen, Sune F.; Flyger, Henrik; Lambrechts, Diether; Thienpont, Bernard; Neven, Patrick; Wildiers, Hans; Broeks, Annegien; Van’t Veer, Laura J.; Rutgers, Emiel J. Th.; Couch, Fergus J.; Olson, Janet E.; Hallberg, Emily; Vachon, Celine; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Peto, Julian; dos-Santos-Silva, Isabel; Gibson, Lorna; Nevanlinna, Heli; Muranen, Taru A.; Aittomäki, Kristiina; Blomqvist, Carl; Hall, Per; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Kang, Daehee; Choi, Ji-Yeob; Park, Sue K.; Noh, Dong-Young; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Guénel, Pascal; Truong, Thérčse; Menegaux, Florence; Sanchez, Marie; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Wu, Anna H.; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O.; Benitez, Javier; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Menéndez, Primitiva; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Qiuyin; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Tchatchou, Sandrine; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Australian Ovarian Cancer Management Group; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Lindblom, Annika; Margolin, Sara; Teo, Soo Hwang; Yip, Cheng Har; Lee, Daphne S. C.; Wong, Tien Y.; Hooning, Maartje J.; Martens, John W. M.; Collée, J. Margriet; van Deurzen, Carolien H. M.; Hopper, John L.; Southey, Melissa C.; Tsimiklis, Helen; Kapuscinski, Miroslav K.; Shen, Chen-Yang; Wu, Pei-Ei; Yu, Jyh-Cherng; Chen, Shou-Tung; Grenaker Alnćs, Grethe; Borresen-Dale, Anne-Lise; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Hartman, Mikael; Miao, Hui; Syed Buhari, Shaik Ahmad Bin; Teo, Yik Ying; Fasching, Peter A.; Haeberle, Lothar; Ekici, Arif B.; Beckmann, Matthias W.; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Schoemaker, Minouk J.; García-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Simard, Jacques; Goldberg, Mark S.; Labrčche, France; Dumont, Martine; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Brauch, Hiltrud; Brüning, Thomas; Koto, Yon-Dschun; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Volorio, Sara; Dörk, Thilo; Bogdanova, Natalia V.; Helbig, Sonja; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Devilee, Peter; Tollenaar, Robert A. E. M.; Seynaeve, Caroline; Van Asperen, Christi J.; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Slager, Susan; Toland, Amanda E.; Ambrosone, Christine B.; Yannoukakos, Drakoulis; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Hamann, Ute; Torres, Diana; Zheng, Wei; Long, Jirong; Anton-Culver, Hoda; Neuhausen, Susan L.; Luccarini, Craig; Baynes, Caroline; Ahmed, Shahana; Maranian, Mel; Healey, Catherine S.; González-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Álvarez, Nuria; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; de Santiago, Ines; Carroll, Jason; Caldas, Carlos; Brown, Melissa A.; Lupien, Mathieu; Kristensen, Vessela N.; Pharoah, Paul D. P.; Chenevix-Trench, Georgia; French, Juliet D.; Easton, Douglas F.; Dunning, Alison M.

    2014-09-23

    school, Warwick University, Coventry CV4 7AL, UK. 84. Institute of Population Health, University of Manchester, Manchester M13 9PL, UK. 85. Ministry of Public Health, Bangkok 10400, Thailand. 86. Department of Surgery, Yong Loo Lin School... Hannover, Germany. 118. Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany. 119. Cancer Center of Eastern Finland, University of Eastern Finland, FI-70211 Kuopio, Finland. 120. Imaging Center, Department of Clinical...

  19. The effect of gender on Helicobacter pylori and gastric cancer

    E-Print Network [OSTI]

    Sheh, Alexander

    2011-01-01

    Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium ...

  20. Reference computations of public dose and cancer risk from airborne releases of uranium and Class W plutonium

    SciTech Connect (OSTI)

    Peterson, V.L.

    1995-06-06

    This report presents ``reference`` computations that can be used by safety analysts in the evaluations of the consequences of postulated atmospheric releases of radionuclides from the Rocky Flats Environmental Technology Site. These computations deal specifically with doses and health risks to the public. The radionuclides considered are Class W Plutonium, all classes of Enriched Uranium, and all classes of Depleted Uranium. (The other class of plutonium, Y, was treated in an earlier report.) In each case, one gram of the respirable material is assumed to be released at ground leveL both with and without fire. The resulting doses and health risks can be scaled to whatever amount of release is appropriate for a postulated accident being investigated. The report begins with a summary of the organ-specific stochastic risk factors appropriate for alpha radiation, which poses the main health risk of plutonium and uranium. This is followed by a summary of the atmospheric dispersion factors for unfavorable and typical weather conditions for the calculation of consequences to both the Maximum Offsite Individual and the general population within 80 km (50 miles) of the site.

  1. Making sense of cancer risk Hereditary factors account for only a small portion (10-20%) of

    E-Print Network [OSTI]

    Chen, Tsuhan

    as studies of human populations, cell cultures, and other methods are each important sources of scientific to determine the extent to which a chemical may pose a risk to human health. Not all man-made chemicals hold cases each year. The vast majority of cases can be attrib- uted to environmental factors

  2. Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts

    E-Print Network [OSTI]

    Kelly, KM; Dean, J; Comulada, WS; Lee, SJ

    2010-01-01

    at high risk for breast cancer with MR imaging. Breast Can-Findings from the Breast Cancer Surveillance Consortium:women undergoing biopsy after screening mammography. Cancer

  3. Touschek Lifetime Calculations for NSLS-II

    SciTech Connect (OSTI)

    Nash,B.; Kramer, S.

    2009-05-04

    The Touschek effect limits the lifetime for NSLS-II. The basic mechanism is Coulomb scattering resulting in a longitudinal momentum outside the momentum aperture. The momentum aperture results from a combination of the initial betatron oscillations after the scatter and the non-linear properties determining the resultant stability. We find that higher order multipole errors may reduce the momentum aperture, particularly for scattered particles with energy loss. The resultant drop in Touschek lifetime is minimized, however, due to less scattering in the dispersive regions. We describe these mechanisms, and present calculations for NSLS-II using a realistic lattice model including damping wigglers and engineering tolerances.

  4. Measurement of the Omega0(c) lifetime

    SciTech Connect (OSTI)

    Iori, M.; Ayan, A.S.; Akgun, U.; Alkhazov, G.; Amaro-Reyes, J.; Atamantchouk, A.G.; Balatz, M.Y.; Blanco-Covarrubias, A.; Bondar, N.F.; Cooper, P.S.; Dauwe, L.J.; /Ball State U. /Bogazici U. /Carnegie Mellon U. /Rio de Janeiro, CBPF /Fermilab /Serpukhov, IHEP /Beijing, Inst. High Energy Phys. /Moscow, ITEP /Heidelberg, Max Planck Inst. /Moscow State U. /St. Petersburg, INP

    2007-01-01

    The authors report a precise measurement of the {Omega}{sub c}{sup 0} lifetime. The data were taken by the SELEX (E781) experiment using 600 GeV/c {Sigma}{sup -}, {pi}{sup -} and p beams. The measurement has been made using 83 {+-} 19 reconstructed {Omega}{sub c}{sup 0} in the {Omega}{sup -} {pi}{sup -}{pi}{sup +}{pi}{sup +} and {Omega}{sup -} {pi}{sup +} decay modes. The lifetime of the {Omega}{sub c}{sup 0} is measured to be 65 {+-} 13(stat) {+-} 9(sys) fs.

  5. Prompt Neutron Lifetime for the NBSR Reactor

    SciTech Connect (OSTI)

    Hanson, A.L.; Diamond, D.

    2012-06-24

    In preparation for the proposed conversion of the National Institute of Standards and Technology (NIST) research reactor (NBSR) from high-enriched uranium (HEU) to low-enriched uranium (LEU) fuel, certain point kinetics parameters must be calculated. We report here values of the prompt neutron lifetime that have been calculated using three independent methods. All three sets of calculations demonstrate that the prompt neutron lifetime is shorter for the LEU fuel when compared to the HEU fuel and longer for the equilibrium end-of-cycle (EOC) condition when compared to the equilibrium startup (SU) condition for both the HEU and LEU fuels.

  6. A Dosimetric Comparison of Tomotherapy and Volumetric Modulated Arc Therapy in the Treatment of High-Risk Prostate Cancer With Pelvic Nodal Radiation Therapy

    SciTech Connect (OSTI)

    Pasquier, David; Universite Lille Nord de France, Lille; Centre Galilee, Clinique de la Louviere, Lille ; Cavillon, Fabrice; Faculte Libre de Medecine, Lille ; Lacornerie, Thomas; Universite Lille Nord de France, Lille ; Touzeau, Claire; Tresch, Emmanuelle; Lartigau, Eric; Universite Lille Nord de France, Lille

    2013-02-01

    Purpose: To compare the dosimetric results of volumetric modulated arc therapy (VMAT) and helical tomotherapy (HT) in the treatment of high-risk prostate cancer with pelvic nodal radiation therapy. Methods and Materials: Plans were generated for 10 consecutive patients treated for high-risk prostate cancer with prophylactic whole pelvic radiation therapy (WPRT) using VMAT and HT. After WPRT, a sequential boost was delivered to the prostate. Plan quality was assessed according to the criteria of the International Commission on Radiation Units and Measurements 83 report: the near-minimal (D98%), near-maximal (D2%), and median (D50%) doses; the homogeneity index (HI); and the Dice similarity coefficient (DSC). Beam-on time, integral dose, and several organs at risk (OAR) dosimetric indexes were also compared. Results: For WPRT, HT was able to provide a higher D98% than VMAT (44.3 {+-} 0.3 Gy and 43.9 {+-} 0.5 Gy, respectively; P=.032) and a lower D2% than VMAT (47.3 {+-} 0.3 Gy and 49.1 {+-} 0.7 Gy, respectively; P=.005), leading to a better HI. The DSC was better for WPRT with HT (0.89 {+-} 0.009) than with VMAT (0.80 {+-} 0.02; P=.002). The dosimetric indexes for the prostate boost did not differ significantly. VMAT provided better rectum wall sparing at higher doses (V70, V75, D2%). Conversely, HT provided better bladder wall sparing (V50, V60, V70), except at lower doses (V20). The beam-on times for WPRT and prostate boost were shorter with VMAT than with HT (3.1 {+-} 0.1 vs 7.4 {+-} 0.6 min, respectively; P=.002, and 1.5 {+-} 0.05 vs 3.7 {+-} 0.3 min, respectively; P=.002). The integral dose was slightly lower for VMAT. Conclusion: VMAT and HT provided very similar and highly conformal plans that complied well with OAR dose-volume constraints. Although some dosimetric differences were statistically significant, they remained small. HT provided a more homogeneous dose distribution, whereas VMAT enabled a shorter delivery time.

  7. Out-of-field organ doses and associated radiogenic risks from para-aortic radiotherapy for testicular seminoma

    SciTech Connect (OSTI)

    Mazonakis, Michalis Berris, Theocharis; Damilakis, John; Varveris, Charalambos; Lyraraki, Efrossyni

    2014-05-15

    Purpose: The aims of this study were to (a) calculate the radiation dose to out-of-field organs from radiotherapy for stage I testicular seminoma and (b) estimate the associated radiogenic risks. Methods: Monte Carlo methodology was employed to model radiation therapy with typical anteroposterior and posteroanterior para-aortic fields on an anthropomorphic phantom simulating an average adult. The radiation dose received by all main and remaining organs that defined by the ICRP publication 103 and excluded from the treatment volume was calculated. The effect of field dimensions on each organ dose was determined. Additional therapy simulations were generated by introducing shielding blocks to protect the kidneys from primary radiation. The gonadal dose was employed to assess the risk of heritable effects for irradiated male patients of reproductive potential. The lifetime attributable risks (LAR) of radiotherapy-induced cancer were estimated using gender- and organ-specific risk coefficients for patient ages of 20, 30, 40, and 50 years old. The risk values were compared with the respective nominal risks. Results: Para-aortic irradiation to 20 Gy resulted in out-of-field organ doses of 5.0–538.6 mGy. Blocked field treatment led to a dose change up to 28%. The mean organ dose variation by increasing or decreasing the applied field dimensions was 18.7% ± 3.9% and 20.8% ± 4.5%, respectively. The out-of-field photon doses increased the lifetime intrinsic risk of developing thyroid, lung, bladder, prostate, and esophageal cancer by (0.1–1.4)%, (0.4–1.1)%, (2.5–5.4)%, (0.2–0.4)%, and (6.4–9.2)%, respectively, depending upon the patient age at exposure and the field size employed. A low risk for heritable effects of less than 0.029% was found compared with the natural incidence of these defects. Conclusions: Testicular cancer survivors are subjected to an increased risk for the induction of bladder and esophageal cancer following para-aortic radiotherapy. The probability for the appearance of any other malignant disease to out-of-field organs was slightly elevated in respect to the nominal cancer incidence rates.

  8. Lifetime Ruin Minimization: Should Retirees Hedge Inflation

    E-Print Network [OSTI]

    Huang, Huaxiong

    - conomic inflation rate for the population. For example in the U.S. the Consumer Price Index (CPI) has happy, in the appendix we also solve the model by maximizing utility of lifetime consumption. Either way industry is shifting its attention from wealth accumulation to generating a sustainable retirement income

  9. APPLICATIONS RIE-induced carrier lifetime degradation

    E-Print Network [OSTI]

    environmental impact [11,12]. However, RIE generates defects in the near-surface region of the semiconductor [13 in the fabrication of some types of solar cells to achieve a highly directional etch. However, cells fabricated using. Characterisation of the carrier lifetime in solar cells was conducted using the quasi steady state photoconductance

  10. Overview of Field Experience - Degradation Rates & Lifetimes

    SciTech Connect (OSTI)

    Jordan, Dirk; Kurtz, Sarah

    2015-09-14

    The way a PV module fails may depend not only on its design and the materials used in its construction, but also on the weather it experiences, the way it is mounted, and the quality control during its manufacture. This presentation gives an overview of Field Experience - what degradation rates and what lifetimes are being observed in various regions.

  11. Integration of copy number and transcriptomics provides risk stratification in prostate cancer: a discovery and validation cohort study

    E-Print Network [OSTI]

    Ross-Adams, H.; Lamb, A. D.; Dunning, M. J.; Halim, S.; Lindberg, J.; Massie, C. M.; Egevad, L. A.; Russell, R.; Ramos-Montoya, A.; Vowler, S. L.; Sharma, N. L.; Kay, J.; Whitaker, H.; Clark, J.; Hurst, R.; Gnanapragasam, V. J.; Shah, N. C.; Warren, A. Y.; Cooper, C. S.; Lynch, A. G.; Stark, R.; Mills, I. G.; Grönberg, H.; Neal, D. E.

    2015-01-01

    ), and positive surgical margins (PSM). We also compared each subgroup to the best outcome cluster (iCluster4) (Fig. 4D), in a combined analysis of the Cambridge and Stockholm data sets, to ensure sufficient power for robust statistical testing37. We found... that iClusters1 and 3 identified men with the highest risk of relapse more effectively than either elevated Gleason score (?4+3), high PSA, ECE or PSM. Genomic features of the molecular subtypes identified In both the Cambridge and Stockholm...

  12. Modeling the Risk of Radiation-Induced Acute Esophagitis for Combined Washington University and RTOG Trial 93-11 Lung Cancer Patients

    SciTech Connect (OSTI)

    Huang, Ellen X.; Bradley, Jeffrey D.; El Naqa, Issam [Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO (United States); Hope, Andrew J.; Lindsay, Patricia E. [Princess Margaret Hospital, Toronto, ON (Canada); Bosch, Walter R.; Matthews, John W. [Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO (United States); Sause, William T. [Department of Radiation Oncology, LDS Hospital, Salt Lake City, UT (United States); Graham, Mary V. [Department of Radiation Oncology, Phelps County Regional Hospital, Rolla, MO (United States); Deasy, Joseph O., E-mail: deasyj@mskcc.org [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

    2012-04-01

    Purpose: To construct a maximally predictive model of the risk of severe acute esophagitis (AE) for patients who receive definitive radiation therapy (RT) for non-small-cell lung cancer. Methods and Materials: The dataset includes Washington University and RTOG 93-11 clinical trial data (events/patients: 120/374, WUSTL = 101/237, RTOG9311 = 19/137). Statistical model building was performed based on dosimetric and clinical parameters (patient age, sex, weight loss, pretreatment chemotherapy, concurrent chemotherapy, fraction size). A wide range of dose-volume parameters were extracted from dearchived treatment plans, including Dx, Vx, MOHx (mean of hottest x% volume), MOCx (mean of coldest x% volume), and gEUD (generalized equivalent uniform dose) values. Results: The most significant single parameters for predicting acute esophagitis (RTOG Grade 2 or greater) were MOH85, mean esophagus dose (MED), and V30. A superior-inferior weighted dose-center position was derived but not found to be significant. Fraction size was found to be significant on univariate logistic analysis (Spearman R = 0.421, p < 0.00001) but not multivariate logistic modeling. Cross-validation model building was used to determine that an optimal model size needed only two parameters (MOH85 and concurrent chemotherapy, robustly selected on bootstrap model-rebuilding). Mean esophagus dose (MED) is preferred instead of MOH85, as it gives nearly the same statistical performance and is easier to compute. AE risk is given as a logistic function of (0.0688 Asterisk-Operator MED+1.50 Asterisk-Operator ConChemo-3.13), where MED is in Gy and ConChemo is either 1 (yes) if concurrent chemotherapy was given, or 0 (no). This model correlates to the observed risk of AE with a Spearman coefficient of 0.629 (p < 0.000001). Conclusions: Multivariate statistical model building with cross-validation suggests that a two-variable logistic model based on mean dose and the use of concurrent chemotherapy robustly predicts acute esophagitis risk in combined-data WUSTL and RTOG 93-11 trial datasets.

  13. Sunitinib Plus Androgen Deprivation and Radiation Therapy for Patients With Localized High-Risk Prostate Cancer: Results From a Multi-institutional Phase 1 Study

    SciTech Connect (OSTI)

    Corn, Paul G.; Song, Danny Y.; Heath, Elisabeth; Maier, Jordan; Meyn, Raymond; Kuban, Deborah; DePetrillo, Thomas A.; Mathew, Paul

    2013-07-01

    Purpose: To evaluate the feasibility of administering sunitinib in combination with androgen deprivation therapy and external-beam intensity modulated radiation therapy (XRT) in patients with localized high-risk prostate cancer. Methods and Materials: Seventeen men with localized adenocarcinoma of the prostate with cT2c-cT4 or Gleason 8-10 or prostate-specific antigen >20 ng/mL received initial androgen deprivation (leuprolide 22.5 mg every 12 weeks plus oral bicalutamide 50 mg daily) for 4-8 weeks before oral sunitinib 12.5, 25, or 37.5 mg daily for 4 weeks as lead-in, then concurrently with and 4 weeks after XRT (75.6 Gy in 42 fractions to prostate and seminal vesicles). A 3+3 sequential dose-escalation design was used to assess the frequency of dose-limiting toxicity (DLT) and establish a maximal tolerated dose of sunitinib. Results: Sunitinib at 12.5- and 25-mg dose levels was well tolerated. The first 4 patients enrolled at 37.5 mg experienced a DLT during lead-in, and a drug interaction between sunitinib and bicalutamide was suspected. The protocol was revised and concurrent bicalutamide omitted. Of the next 3 patients enrolled at 37.5 mg, 2 of 3 receiving concurrent therapy experienced DLTs during radiation: grade 3 diarrhea and grade 3 proctitis, respectively. Only 1 of 7 patients completed sunitinib at 37.5 mg daily, whereas 3 of 3 patients (25 mg as starting dose) and 3 of 4 patients (25 mg as reduced dose) completed therapy. Conclusions: The feasibility of combined vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR) inhibitor therapy, androgen deprivation, and radiation therapy for prostate cancer was established. Using a daily dosing regimen with lead-in, concurrent, and post-XRT therapy, the recommended phase 2 dose of sunitinib is 25 mg daily.

  14. A study on planning organ at risk volume for the rectum using cone beam computed tomography in the treatment of prostate cancer

    SciTech Connect (OSTI)

    Prabhakar, Ramachandran; Oates, Richard; Jones, Daryl; Kron, Tomas; Cramb, Jim; Foroudi, Farshad; Geso, Moshi; Gill, Suki

    2014-04-01

    In this study, we analyzed planning organ at risk volume (PRV) for the rectum using a series of cone beam computed tomographies (CBCTs) acquired during the treatment of prostate cancer and evaluated the dosimetric effect of different PRV definitions. Overall, 21 patients with prostate cancer were treated radically with 78 Gy in 39 fractions had in total 418 CBCTs, each acquired at the end of the first 5 fractions and then every alternate fraction. The PRV was generated from the Boolean sum volume of the rectum obtained from first 5 fractions (PRV-CBCT-5) and from all CBCTs (PRV-CBCT-All). The PRV margin was compared at the superior, middle, and inferior slices of the contoured rectum to compare PRV-CBCT-5 and PRV-CBCT-All. We also compared the dose received by the planned rectum (Rectum-computed tomography [CT]), PRV-CBCT-5, PRV-CBCT-All, and average rectum (CBCT-AV-dose-volume histogram [DVH]) at critical dose levels. The average measured rectal volume for all 21 patients for Rectum-CT, PRV-CBCT-5, and PRV-CBCT-All was 44.3 ± 15.0, 92.8 ± 40.40, and 121.5 ± 36.7 cm{sup 3}, respectively. For PRV-CBCT-All, the mean ± standard deviation displacement in the anterior, posterior, right, and left lateral directions in centimeters was 2.1 ± 1.1, 0.9 ± 0.5, 0.9 ± 0.8, and 1.1 ± 0.7 for the superior rectum; 0.8 ± 0.5, 1.1 ± 0.5, 1.0 ± 0.5, and 1.0 ± 0.5 for the middle rectum; and 0.3 ± 0.3; 0.9 ± 0.5; 0.4 ± 0.2, and 0.5 ± 0.3 for the inferior rectum, respectively. The first 5 CBCTs did not predict the PRV for individual patients. Our study shows that the PRV margin is different for superior, middle, and the inferior parts of the rectum, it is wider superiorly and narrower inferiorly. A uniform PRV margin does not represent the actual rectal variations during treatment for all treatment fractions. The large variation in interpatient rectal size implies a potential role for adaptive radiotherapy for prostate cancer.

  15. A Model to Estimate the Risk of Breast Cancer-Related Lymphedema: Combinations of Treatment-Related Factors of the Number of Dissected Axillary Nodes, Adjuvant Chemotherapy, and Radiation Therapy

    SciTech Connect (OSTI)

    Kim, Myungsoo; Kim, Seok Won; Lee, Sung Uk; Lee, Nam Kwon; Jung, So-Youn; Kim, Tae Hyun; Lee, Eun Sook; Kang, Han-Sung; Shin, Kyung Hwan

    2013-07-01

    Purpose: The development of breast cancer-related lymphedema (LE) is closely related to the number of dissected axillary lymph nodes (N-ALNs), chemotherapy, and radiation therapy. In this study, we attempted to estimate the risk of LE based on combinations of these treatment-related factors. Methods and Materials: A total of 772 patients with breast cancer, who underwent primary surgery with axillary lymph node dissection from 2004 to 2009, were retrospectively analyzed. Adjuvant chemotherapy (ACT) was performed in 677 patients (88%). Among patients who received radiation therapy (n=675), 274 (35%) received supraclavicular radiation therapy (SCRT). Results: At a median follow-up of 5.1 years (range, 3.0-8.3 years), 127 patients had developed LE. The overall 5-year cumulative incidence of LE was 17%. Among the 127 affected patients, LE occurred within 2 years after surgery in 97 (76%) and within 3 years in 115 (91%) patients. Multivariate analysis showed that N-ALN (hazard ratio [HR], 2.81; P<.001), ACT (HR, 4.14; P=.048), and SCRT (HR, 3.24; P<.001) were independent risk factors for LE. The total number of risk factors correlated well with the incidence of LE. Patients with no risk or 1 risk factor showed a significantly lower 5-year probability of LE (3%) than patients with 2 (19%) or 3 risk factors (38%) (P<.001). Conclusions: The risk factors associated with LE were N-ALN, ACT, and SCRT. A simple model using combinations of these factors may help clinicians predict the risk of LE.

  16. Photovoltaic Lifetime & Degradation Science Statistical Pathway Development: Acrylic Degradation

    E-Print Network [OSTI]

    Rollins, Andrew M.

    Photovoltaic Lifetime & Degradation Science Statistical Pathway Development: Acrylic Degradation, USA ABSTRACT In order to optimize and extend the life of photovoltaics (PV) modules, scientific photovoltaics. The statisti- cally significant relationships were investigated using lifetime and degradation

  17. Degradation Pathway Models for Photovoltaics Module Lifetime Performance

    E-Print Network [OSTI]

    Rollins, Andrew M.

    Degradation Pathway Models for Photovoltaics Module Lifetime Performance Nicholas R. Wheeler, Laura data from Underwriter Labs, featuring measurements taken on 18 identical photovoltaic (PV) modules in modules and their effects on module performance over lifetime. Index Terms--photovoltaics, statistical

  18. Battery Lifetime-Aware Automotive Climate Control for Electric Vehicles

    E-Print Network [OSTI]

    Al Faruque, Mohammad Abdullah

    Battery Lifetime-Aware Automotive Climate Control for Electric Vehicles Korosh Vatanparvar) optimization involves stringent con- straints on driving range and battery lifetime. Sophisticated embedded systems and huge number of computing resources have enabled re- searchers to implement advanced Battery

  19. Neutrinos and cosmology: a lifetime relationship

    SciTech Connect (OSTI)

    Serpico, Pasquale D.; /Fermilab

    2008-06-01

    We consider the example of neutrino decays to illustrate the profound relation between laboratory neutrino physics and cosmology. Two case studies are presented: In the first one, we show how the high precision cosmic microwave background spectral data collected by the FIRAS instrument on board of COBE, when combined with Lab data, have greatly changed bounds on the radiative neutrino lifetime. In the second case, we speculate on the consequence for neutrino physics of the cosmological detection of neutrino masses even as small as {approx}0.06 eV, the lower limit guaranteed by neutrino oscillation experiments. We show that a detection at that level would improve by many orders of magnitude the existing limits on neutrino lifetime, and as a consequence on some models of neutrino secret interactions.

  20. The Expected Lifetime of an Extraction Project

    E-Print Network [OSTI]

    Sidorov, Nikita

    sources, such as polit- ical risk and labour market changes, however, the key financial uncertainties be of great use to a company, as it is a quantitative measure of a project's risk, and easily interpreted

  1. Elevated levels of somatic mutation of the glycophorin A locus in cancer patients: Relevance for incidence of secondary cancer

    SciTech Connect (OSTI)

    Grant, S.G.; Bigbee, W.L. [Univ. of Pittsburgh, PA (United States)

    1994-09-01

    The glycophorin A (GPA)-based human in vivo somatic mutation assay was used to survey a large number of newly diagnosed cancer patients presenting with a variety of solid tumors. This cancer patient population was sampled pre-therapy and frequencies of two types of variant cells determined: allele loss segregants arising by mutation, deletion, chromosome loss or gene inactivation, and allele loss and duplication segregants arising by chromosome missegregation, mitotic recombination and possibly gene conversion. When compared with matched controls, the cancer patient population exhibited significantly elevated frequencies of both types of segregants. Cancer patients undergoing genotoxic therapy with chemicals and/or ionizing radiation were then examined, yielding variable results depending on the particular agent. In patients receiving localized high dose radiotherapy there was no response with either endpoint. In most cases involving chemotherapy, a significant elevation in the frequency of allele loss variants was observed within one month of the initiation of therapy which persisted at least one erythrocyte lifetime ({approximately}4 months) post therapy. In a subset of these cases, specifically, involving the known stem cell mutagen cis-platinum, the allele loss variant cell frequency remained significantly elevated up to 7 years after treatment. These results indicate that individuals with cancer have inherently higher levels of somatic mutation and segregation, due to genetic predisposition or exposure to environmental genotoxicants, or both, and that certain types of cancer therapy add significantly to the burden of mutation. These data provide a molecular rationale for the increased frequency of secondary malignancy observed in primary cancer patients: they are at increased risk of already having or easily acquiring the necessary carcinogenic events implicated in the progression of multi-step oncogenesis.

  2. Activation of protein kinase B (PKB/Akt) and risk of lung cancer among rural women in India who cook with biomass fuel

    SciTech Connect (OSTI)

    Roychoudhury, Sanghita; Mondal, Nandan Kumar; Mukherjee, Sayali; Dutta, Anindita; Siddique, Shabana; Ray, Manas Ranjan

    2012-02-15

    The impact of indoor air pollution (IAP) from biomass fuel burning on the risk of carcinogenesis in the airways has been investigated in 187 pre-menopausal women (median age 34 years) from eastern India who cooked exclusively with biomass and 155 age-matched control women from same locality who cooked with cleaner fuel liquefied petroleum gas. Compared with control, Papanicolau-stained sputum samples showed 3-times higher prevalence of metaplasia and 7-times higher prevalence of dysplasia in airway epithelial cell (AEC) of biomass users. Immunocytochemistry showed up-regulation of phosphorylated Akt (p-Akt{sup ser473} and p-Akt{sup thr308}) proteins in AEC of biomass users, especially in metaplastic and dysplastic cells. Compared with LPG users, biomass-using women showed marked rise in reactive oxygen species (ROS) generation and depletion of antioxidant enzyme, superoxide dismutase (SOD) indicating oxidative stress. There were 2–5 times more particulate pollutants (PM{sub 10} and PM{sub 2.5}), 72% more nitrogen dioxide and 4-times more particulate-laden benzo(a)pyrene, but no change in sulfur dioxide in indoor air of biomass-using households, and high performance liquid chromatography estimated 6-fold rise in the concentration of benzene metabolite trans,trans-muconic acid (t,t-MA) in urine of biomass users. Metaplasia and dysplasia, p-Akt expression and ROS generation were positively associated with PM and t,t-MA levels. It appears that cumulative exposure to biomass smoke increases the risk of lung carcinogenesis via oxidative stress-mediated activation of Akt signal transduction pathway. -- Highlights: ? Carcinogenesis in airway cells was examined in biomass and LPG using women. ? Metaplasia and dysplasia of epithelial cells were more prevalent in biomass users. ? Change in airway cytology was associated with oxidative stress and Akt activation. ? Biomass users had greater exposure to respirable PM, B(a)P and benzene. ? Cooking with biomass increases cancer risk in the airways via Akt activation.

  3. Common variation in EMSYand risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs

    E-Print Network [OSTI]

    Benusiglio, Patrick R.; Lesueur, Fabienne; Luccarini, Craig; McIntosh, Joan; Luben, Robert; Smith, Paula; Dunning, Alison M.; Easton, Douglas F.; Ponder, Bruce A. J.; Pharoah, Paul D. P.

    2005-07-19

    Abstract Background EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast cancer patients. Furthermore...

  4. Lifetime Analysis at High Intensity Colliders Applied to the LHC

    E-Print Network [OSTI]

    Salvachua, B; Bruce, R; Burkart, F; Redaelli, S; Valentino, G; Wollmann, D

    2013-01-01

    The beam lifetime is one of the main parameters to define the performance of a collider. In a super-conducting machine like the LHC, the lifetime determines the intensity reach for a given collimation cleaning. The beam lifetime can be calculated from the direct measurement of beam current. However, due to the noise in the beam current signal only an average lifetime over several seconds can be calculated. We propose here an alternative method, which uses the signal of the beam loss monitors in the vicinity of the primary collimators to get the instantaneous beam lifetime at the collimators. In this paper we compare the lifetime from the two methods and investigate the minimum lifetime over the LHC cycle for all the physics fills in 2011 and 2012. These data provide a reference for estimates of performance reach from collimator cleaning.

  5. Anterior Myocardial Territory May Replace the Heart as Organ at Risk in Intensity-Modulated Radiotherapy for Left-Sided Breast Cancer

    SciTech Connect (OSTI)

    Tan Wenyong; Liu Dong; Xue Chenbin; Xu Jiaozhen; Li Beihui; Chen Zhengwang; Hu Desheng; Wang Xionghong

    2012-04-01

    Purpose: We investigated whether the heart could be replaced by the anterior myocardial territory (AMT) as the organ at risk (OAR) in intensity-modulated radiotherapy (IMRT) of the breast for patients with left-sided breast cancer. Methods and Materials: Twenty-three patients with left-sided breast cancer who received postoperative radiation after breast-conserving surgery were studied. For each patient, we generated five IMRT plans including heart (H), left ventricle (LV), AMT, LV+AMT, and H+LV as the primary OARs, respectively, except both lungs and right breast, which corresponded to IMRT(H), IMRT(LV), IMRT(AMT), IMRT(LV+AMT), and IMRT(H+LV). For the planning target volumes and OARs, the parameters of dose-volume histograms were compared. Results: The homogeneity index, conformity index, and coverage index were not compromised significantly in IMRT(AMT), IMRT(LV) and IMRT(LV+ AMT), respectively, when compared with IMRT(H). The mean dose to the heart, LV, and AMT decreased 5.3-21.5% (p < 0.05), 19.9-29.5% (p < 0.05), and 13.3-24.5% (p < 0.05), respectively. Similarly, the low (e.g., V5%), middle (e.g., V20%), and high (e.g., V30%) dose-volume of the heart, LV, and AMT decreased with different levels. The mean dose and V10% of the right lung increased by 9.2% (p < 0.05) and 27.6% (p < 0.05), respectively, in IMRT(LV), and the mean dose and V5% of the right breast decreased significantly in IMRT(AMT) and IMRT(LV+AMT). IMRT(AMT) was the preferred plan and was then compared with IMRT(H+LV); the majority of dose-volume histogram parameters of OARs including the heart, LV, AMT, both lungs, and the right breast were not statistically different. However, the low dose-volume of LV increased and the middle dose-volume decreased significantly (p < 0.05) in IMRT(AMT). Also, those of the right lung (V10%, V15%) and right breast (V5%, V10%) decreased significantly (p < 0.05). Conclusions: The AMT may replace the heart as the OAR in left-sided breast IMRT after breast-conserving surgery to decrease the radiation dose to the heart.

  6. Final report on reliability and lifetime prediction.

    SciTech Connect (OSTI)

    Gillen, Kenneth Todd; Wise, Jonathan; Jones, Gary D.; Causa, Al G.; Terrill, Edward R.; Borowczak, Marc

    2012-12-01

    This document highlights the important results obtained from the subtask of the Goodyear CRADA devoted to better understanding reliability of tires and to developing better lifetime prediction methods. The overall objective was to establish the chemical and physical basis for the degradation of tires using standard as well as unique models and experimental techniques. Of particular interest was the potential application of our unique modulus profiling apparatus for assessing tire properties and for following tire degradation. During the course of this complex investigation, extensive relevant information was generated, including experimental results, data analyses and development of models and instruments. Detailed descriptions of the findings are included in this report.

  7. Analog detection for cavity lifetime spectroscopy

    DOE Patents [OSTI]

    Zare, Richard N. (Stanford, CA); Harb, Charles C. (Palo Alto, CA); Paldus, Barbara A. (Mountain View, CA); Spence, Thomas G. (Palo Alto, CA)

    2003-01-01

    An analog detection system for determining a ring-down rate or decay rate 1/.tau. of an exponentially decaying ring-down beam issuing from a lifetime or ring-down cavity during a ring-down phase. Alternatively, the analog detection system determines a build-up rate of an exponentially growing beam issuing from the cavity during a ring-up phase. The analog system can be employed in continuous wave cavity ring-down spectroscopy (CW CRDS) and pulsed CRDS (P CRDS) arrangements utilizing any type of ring-down cavity including ring-cavities and linear cavities.

  8. Analog detection for cavity lifetime spectroscopy

    DOE Patents [OSTI]

    Zare, Richard N. (Stanford, CA); Harb, Charles C. (Palo Alto, CA); Paldus, Barbara A. (Mountain View, CA); Spence, Thomas G. (Palo Alto, CA)

    2001-05-15

    An analog detection system for determining a ring-down rate or decay rate 1/.tau. of an exponentially decaying ring-down beam issuing from a lifetime or ring-down cavity during a ring-down phase. Alternatively, the analog detection system determines a build-up rate of an exponentially growing beam issuing from the cavity during a ring-up phase. The analog system can be employed in continuous wave cavity ring-down spectroscopy (CW CRDS) and pulsed CRDS (P CRDS) arrangements utilizing any type of ring-down cavity including ring-cavities and linear cavities.

  9. Critical dose and toxicity index of organs at risk in radiotherapy: Analyzing the calculated effects of modified dose fractionation in non–small cell lung cancer

    SciTech Connect (OSTI)

    Pedicini, Piernicola; Strigari, Lidia; Benassi, Marcello; Caivano, Rocchina; Fiorentino, Alba; Nappi, Antonio; Salvatore, Marco; Storto, Giovanni

    2014-04-01

    To increase the efficacy of radiotherapy for non–small cell lung cancer (NSCLC), many schemes of dose fractionation were assessed by a new “toxicity index” (I), which allows one to choose the fractionation schedules that produce less toxic treatments. Thirty-two patients affected by non resectable NSCLC were treated by standard 3-dimensional conformal radiotherapy (3DCRT) with a strategy of limited treated volume. Computed tomography datasets were employed to re plan by simultaneous integrated boost intensity-modulated radiotherapy (IMRT). The dose distributions from plans were used to test various schemes of dose fractionation, in 3DCRT as well as in IMRT, by transforming the dose-volume histogram (DVH) into a biological equivalent DVH (BDVH) and by varying the overall treatment time. The BDVHs were obtained through the toxicity index, which was defined for each of the organs at risk (OAR) by a linear quadratic model keeping an equivalent radiobiological effect on the target volume. The less toxic fractionation consisted in a severe/moderate hyper fractionation for the volume including the primary tumor and lymph nodes, followed by a hypofractionation for the reduced volume of the primary tumor. The 3DCRT and IMRT resulted, respectively, in 4.7% and 4.3% of dose sparing for the spinal cord, without significant changes for the combined-lungs toxicity (p < 0.001). Schedules with reduced overall treatment time (accelerated fractionations) led to a 12.5% dose sparing for the spinal cord (7.5% in IMRT), 8.3% dose sparing for V{sub 20} in the combined lungs (5.5% in IMRT), and also significant dose sparing for all the other OARs (p < 0.001). The toxicity index allows to choose fractionation schedules with reduced toxicity for all the OARs and equivalent radiobiological effect for the tumor in 3DCRT, as well as in IMRT, treatments of NSCLC.

  10. High-Risk Prostate Cancer With Gleason Score 8-10 and PSA Level {<=}15 ng/ mL Treated With Permanent Interstitial Brachytherapy

    SciTech Connect (OSTI)

    Fang, L. Christine [Department of Radiation Oncology, University of Washington, Seattle, WA (United States); Merrick, Gregory S., E-mail: gmerrick@urologicresearchinstitute.org [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV (United States); Butler, Wayne M.; Galbreath, Robert W.; Murray, Brian C.; Reed, Joshua L. [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV (United States); Adamovich, Edward [Department of Pathology, Wheeling Hospital, Wheeling, WV (United States); Wallner, Kent E. [Puget Sound Veterans Affairs Hospital, Seattle, WA (United States)

    2011-11-15

    Purpose: With widespread prostate-specific antigen (PSA) screening, there has been an increase in men diagnosed with high-risk prostate cancer defined by a Gleason score (GS) {>=}8 coupled with a relatively low PSA level. The optimal management of these patients has not been defined. Cause-specific survival (CSS), biochemical progression-free survival (bPFS), and overall survival (OS) were evaluated in brachytherapy patients with a GS {>=}8 and a PSA level {<=}15 ng/mL with or without androgen-deprivation therapy (ADT). Methods and Materials: From April 1995 to October 2005, 174 patients with GS {>=}8 and a PSA level {<=}15 ng/mL underwent permanent interstitial brachytherapy. Of the patients, 159 (91%) received supplemental external beam radiation, and 113 (64.9%) received ADT. The median follow-up was 6.6 years. The median postimplant Day 0 minimum percentage of the dose covering 90% of the target volume was 121.1% of prescription dose. Biochemical control was defined as a PSA level {<=}0.40 ng/mL after nadir. Multiple parameters were evaluated for impact on survival. Results: Ten-year outcomes for patients without and with ADT were 95.2% and 92.5%, respectively, for CSS (p = 0.562); 86.5% and 92.6%, respectively, for bPFS (p = 0.204); and 75.2% and 66.0%, respectively, for OS (p = 0.179). The median post-treatment PSA level for biochemically controlled patients was <0.02 ng/mL. Multivariate analysis failed to identify any predictors for CSS, whereas bPFS and OS were most closely related to patient age. Conclusions: Patients with GS {>=}8 and PSA level {<=}15 ng/mL have excellent bPFS and CSS after brachytherapy with supplemental external beam radiotherapy. The use of ADT did not significantly impact bPFS, CSS, or OS.

  11. Stochastic modeling and survival analysis of marginally trapped neutrons for a magnetic trapping neutron lifetime experiment

    E-Print Network [OSTI]

    K. J. Coakley; M. S. Dewey; M. G. Huber; P. R. Huffman; C. R. Huffer; D. E. Marley; H. P. Mumm; C. M. O'Shaughnessy; K. W. Schelhammer; A. K. Thompson; A. T. Yue

    2015-08-10

    In a variety of neutron lifetime experiments, in addition to $\\beta-$decay, neutrons can be lost by other mechanisms including wall losses. Failure to account for these other loss mechanisms produces systematic measurement error and associated systematic uncertainties in neutron lifetime measurements. In this work, we develop a physical model for neutron wall losses and construct a competing risks survival analysis model to account for losses due to the joint effect of $\\beta-$decay losses, wall losses of marginally trapped neutrons, and an additional absorption mechanism. We determine the survival probability function associated with the wall loss mechanism by a Monte Carlo method. Based on a fit of the competing risks model to a subset of the NIST experimental data, we determine the mean lifetime of trapped neutrons to be approximately 700 s -- considerably less than the current best estimate of (880.1 $\\pm$ 1.1) s promulgated by the Particle Data Group [1]. Currently, experimental studies are underway to determine if this discrepancy can be explained by neutron capture by ${}^3$He impurities in the trapping volume. Analysis of the full NIST data will be presented in a later publication.

  12. Predictive Models of Li-ion Battery Lifetime (Presentation) Smith...

    Office of Scientific and Technical Information (OSTI)

    Predictive Models of Li-ion Battery Lifetime (Presentation) Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G.; Shi, Y.; Pesaran, A. 25 ENERGY STORAGE; 33 ADVANCED PROPULSION...

  13. Battery Lifetime Analysis and Simulation Tool (BLAST) Documentation

    Office of Scientific and Technical Information (OSTI)

    Battery Lifetime Analysis and Simulation Tool (BLAST) Documentation Neubauer, J. 25 ENERGY STORAGE BATTERY; LITHIUM-ION; STATIONARY ENERGY STORAGE; BLAST; BATTERY DEGRADATION;...

  14. Analysis of Incomplete Data in Presence of Dependent Competing Risks

    E-Print Network [OSTI]

    Kundu, Debasis

    Analysis of Incomplete Data in Presence of Dependent Competing Risks Debasis Kundu1 and Sankarshan, the cause of failure of an individual or item may be due to one of several causes. The competing risks model the assumption that the lifetime of the different risks are independent. Kundu and Basu (2000) recently

  15. Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study

    E-Print Network [OSTI]

    Peters, Tricia M.; Moore, Steven C.; Gierach, Gretchen L.; Wareham, Nicholas J.; Ekelund, Ulf; Hollenbeck, Albert R.; Schatzkin, Arthur; Leitzmann, Michael F.

    2009-10-01

    - ously reported effect modifiers including baseline BMI, BMI at age 18 years, family history of breast cancer in first- degree female relatives, parity, and menopausal hormone therapy use, and the statistical significance of the interac- tion was assessed... of breast cancer in a first-degree female relative. ‡MHT: menopausal hormone therapy. BMC Cancer 2009, 9:349 http://www.biomedcentral.com/1471-2407/9/349 ity, the most active women reported that they were leaner at age 18 years than inactive women. Women...

  16. Do Angiotensin-Converting Enzyme Inhibitors Reduce the Risk of Symptomatic Radiation Pneumonitis in Patients With Non-Small Cell Lung Cancer After Definitive Radiation Therapy? Analysis of a Single-Institution Database

    SciTech Connect (OSTI)

    Wang, Hongmei [Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, P.R. of China (China); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang, Yan; Xu, Ting; Nguyen, Quynh-Nhu; Levy, Lawrence B.; O'Reilly, Michael [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gold, Kathryn A. [Department of Thoracic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-12-01

    Purpose: Preclinical studies have suggested that angiotensin-converting enzyme inhibitors (ACEIs) can mitigate radiation-induced lung injury. We sought here to investigate possible associations between ACEI use and the risk of symptomatic radiation pneumonitis (RP) among patients undergoing radiation therapy (RT) for non–small cell lung cancer (NSCLC). Methods and Materials: We retrospectively identified patients who received definitive radiation therapy for stages I to III NSCLC between 2004 and 2010 at a single tertiary cancer center. Patients must have received a radiation dose of at least 60 Gy for a single primary lung tumor and have had imaging and dosimetric data available for analysis. RP was quantified according to Common Terminology Criteria for Adverse Events, version 3.0. A Cox proportional hazard model was used to assess potential associations between ACEI use and risk of symptomatic RP. Results: Of 413 patients analyzed, 65 were using ACEIs during RT. In univariate analysis, the rate of RP grade ?2 seemed lower in ACEI users than in nonusers (34% vs 46%), but this apparent difference was not statistically significant (P=.06). In multivariate analysis of all patients, ACEI use was not associated with the risk of symptomatic RP (hazard ratio [HR] = 0.66; P=.07) after adjustment for sex, smoking status, mean lung dose (MLD), and concurrent carboplatin and paclitaxel chemotherapy. Subgroup analysis showed that ACEI use did have a protective effect from RP grade ?2 among patients who received a low (?20-Gy) MLD (P<.01) or were male (P=.04). Conclusions: A trend toward reduction in symptomatic RP among patients taking ACEIs during RT for NSCLC was not statistically significant on univariate or multivariate analyses, although certain subgroups may benefit from use (ie, male patients and those receiving low MLD). The evidence at this point is insufficient to establish whether the use of ACEIs does or does not reduce the risk of RP.

  17. Lifetime Prediction for Supercapacitor-powered Wireless Sensor Nodes

    E-Print Network [OSTI]

    Turau, Volker

    with a prediction of future incoming energy, e.g., obtained from a solar cell. II. RELATED WORK Several approachesLifetime Prediction for Supercapacitor-powered Wireless Sensor Nodes Christian Renner, J research direction for wireless sensor networks. It depends on accurate models for lifetime prediction

  18. Exploiting Sensor Spatial Redundancy to Improve Network Lifetime

    E-Print Network [OSTI]

    issues. Indeed, recharging or replacing the nodes' battery may be inconvenient, or even impossible- erage. While monitoring the area of interest, sensors gather information (i.e., images), and send battery lifetime should be maximized to maximize network lifetime, a fairly intuitive approach

  19. Lifetime Benefits through Load Balancing in Homogeneous Sensor Networks

    E-Print Network [OSTI]

    Haenggi, Martin

    , battery depletion is emulated so that it becomes possible to actually measure the load balancingLifetime Benefits through Load Balancing in Homogeneous Sensor Networks Daniele Puccinelli network. The use of load balancing schemes can be expected to provide significant lifetime benefits

  20. Astroparticle physics, 2013 Problem 3: Lifetime of electrons

    E-Print Network [OSTI]

    Pohl, Martin Karl Wilhelm

    "the mean lifetime of electrons as function of their energy. The typical matter density in interstellar space is 1 hydrogen atom per cubic centimeter. b) Consider the energy dependence of the lifetime the energy-loss rate of relativistic electrons for bremsstrahlung a) Energy losses imply that high-energy

  1. Cancer Research in Botswana Surbhi Grover, MD MPH

    E-Print Network [OSTI]

    Bushman, Frederic

    Cancer Research in Botswana Surbhi Grover, MD MPH Assistant Professor, Radiation Oncology, UPENN and are developing cancers and other NCDs #12;3 HIV and Cancer wHIV infection increases the risk of cancer wIn the later stages of HIV infection, chronic immunosuppression (& other co-factors) leads to cancer formation

  2. Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

    E-Print Network [OSTI]

    2012-01-01

    The Hereditary Breast and Ovarian Cancer Research GroupHereditary Breast and Ovarian Cancer Study (IOVHBOCS) ThisHungarian Breast and Ovarian Cancer Study (HUNBOCS) The

  3. Neutron lifetime measurements using gravitationally trapped ultracold neutrons

    E-Print Network [OSTI]

    A. P. Serebrov; V. E. Varlamov; A. G. Kharitonov; A. K. Fomin; Yu. N. Pokotilovski; P. Geltenbort; I. A. Krasnoschekova; M. S. Lasakov; R. R. Taldaev; A. V. Vassiljev; O. M. Zherebtsov

    2009-02-02

    Our experiment using gravitationally trapped ultracold neutrons (UCN) to measure the neutron lifetime is reviewed. Ultracold neutrons were trapped in a material bottle covered with perfluoropolyether. The neutron lifetime was deduced from comparison of UCN losses in the traps with different surface-to-volume ratios. The precise value of the neutron lifetime is of fundamental importance to particle physics and cosmology. In this experiment, the UCN storage time is brought closer to the neutron lifetime than in any experiments before:the probability of UCN losses from the trap was only 1% of that for neutron beta decay. The neutron lifetime obtained,878.5+/-0.7stat+/-0.3sys s, is the most accurate experimental measurement to date.

  4. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  5. Impact of Screening and Risk Factors for Local Recurrence and Survival After Conservative Surgery and Radiotherapy for Early Breast Cancer: Results From a Large Series With Long-Term Follow-Up

    SciTech Connect (OSTI)

    Kunkler, Ian H.; Kerr, Gillian R.; Thomas, Jeremy S.; Jack, Wilma J.L.; Bartlett, John M.S.; Pedersen, Hans C.; Cameron, David A.; Dixon, J. Michael; Chetty, Udi

    2012-07-01

    Purpose: To investigate conventional prognostic factors for ipsilateral breast tumor recurrence (IBTR), distant metastasis (DM), and survival after breast-conserving therapy (BCT) in screen-detected and symptomatic cases on surveillance up to 25 years. Patients and Methods: A total of 1812 consecutive patients in three cohorts (1981-1989, 1990-1992, and 1993-1998) with T12N01M0 invasive breast cancer were treated with BCT (median follow-up, 14 years). Tumor type and grade were reviewed by a single pathologist. Hormone receptor status was measured by immunohistochemistry on tissue microarrays. A Cox proportional hazards model was used to assess independent prognostic variables for relapse and survival. Results: A total of 205 IBTR occurred, with 5-, 10-, 15-, and 20-year actuarial relapse rates of 4.5% (95% confidence interval [CI] 3.35-5.5%), 8.4% (95% CI 7.1-9.8%), 14.1% (95% CI 12.0-16%), and 17.4% (95% CI 14.5-20.2%). Number of nodes, young age, pathologic tumor size, and multifocality were significant factors for IBTR. Three hundred seventy-eight patients developed DM. The actuarial metastatic rate was 12% at 5 years and 17.9% at 10 years. Young age, number of positive nodes, pathologic tumor size, and tumor grade were significant factors for DM relapse. When conventional prognostic indices were taken into account screen-detected cancers showed no improvement in overall relapse or survival rate compared with symptomatic cases but did show a reduced risk of DM after IBTR. After 10 years IBTR relapse continued at a constant rate of 0.87% per annum. Conclusions: The Edinburgh BCT series has shown that screen-detected invasive breast cancers do not have significantly different clinical outcomes compared with symptomatic cases when pathologic risk factors are taken into account. This suggests that these patients be managed in a similar way.

  6. Produced water radionuclide hazard/risk assessment, Phase 1

    SciTech Connect (OSTI)

    Hamilton, L.D.; Meinhold, A.F.; Nagy, J.

    1991-06-01

    Petroleum production may be accompanied by the production of saline water, called ``produced water.`` Produced water discharged into freshwater streams, estuaries, coastal and outer continental shelf waters can contained enhanced levels of radium isotopes. This document reports on the first phase of a study to estimate the risk to human health and the environment from radium discharged in produced water. The study involved five major steps: (1) evaluate the usefulness of available produced water outfall data for developing estimates of radium environmental concentrations; (2) review the literature on the bioaccumulation of radium by aquatic organism; (3) review the literature on the effects of radiation on aquatic organisms; (4) review the information available concerning the human health risks associated with exposure to Ra-226 and Ra-228 and (5) perform a conservative, screening-level assessment of the health and environmental risks posed by Ra-226 and Ra-228 discharged in produced waters. A screening-level analysis was performed to determine whether radium discharged to coastal Louisiana in produced waters presents potential health or environmental risks requiring further study. This conservative assessment suggested that no detectable impact on populations of fish, molluscs or crustaceans from radium discharged in produced waters is likely. The analysis also suggested that there is a potential for risk were an individual to ingest a large amount of seafood harvested near a produced water discharge point over a lifetime. The number of excess cancers predicted per year under a conservative scenario is comparable to those expected to result from background concentrations of radium.

  7. Produced water radionuclide hazard/risk assessment, Phase 1

    SciTech Connect (OSTI)

    Hamilton, L.D.; Meinhold, A.F.; Nagy, J.

    1991-06-01

    Petroleum production may be accompanied by the production of saline water, called produced water.'' Produced water discharged into freshwater streams, estuaries, coastal and outer continental shelf waters can contained enhanced levels of radium isotopes. This document reports on the first phase of a study to estimate the risk to human health and the environment from radium discharged in produced water. The study involved five major steps: (1) evaluate the usefulness of available produced water outfall data for developing estimates of radium environmental concentrations; (2) review the literature on the bioaccumulation of radium by aquatic organism; (3) review the literature on the effects of radiation on aquatic organisms; (4) review the information available concerning the human health risks associated with exposure to Ra-226 and Ra-228 and (5) perform a conservative, screening-level assessment of the health and environmental risks posed by Ra-226 and Ra-228 discharged in produced waters. A screening-level analysis was performed to determine whether radium discharged to coastal Louisiana in produced waters presents potential health or environmental risks requiring further study. This conservative assessment suggested that no detectable impact on populations of fish, molluscs or crustaceans from radium discharged in produced waters is likely. The analysis also suggested that there is a potential for risk were an individual to ingest a large amount of seafood harvested near a produced water discharge point over a lifetime. The number of excess cancers predicted per year under a conservative scenario is comparable to those expected to result from background concentrations of radium.

  8. Lifetime of topological quantum memories in thermal environment

    E-Print Network [OSTI]

    Abbas Al-Shimary; James R. Wootton; Jiannis K. Pachos

    2012-09-13

    Here we investigate the effect lattice geometry has on the lifetime of two-dimensional topological quantum memories. Initially, we introduce various lattice patterns and show how the error-tolerance against bit-flips and phase-flips depends on the structure of the underlying lattice. Subsequently, we investigate the dependence of the lifetime of the quantum memory on the structure of the underlying lattice when it is subject to a finite temperature. Importantly, we provide a simple effective formula for the lifetime of the memory in terms of the average degree of the lattice. Finally, we propose optimal geometries for the Josephson junction implementation of topological quantum memories.

  9. Lifetime of the phonons in the PLT ceramic

    SciTech Connect (OSTI)

    Barba-Ortega, J. Joya, M. R.; Londońo, F. A.

    2014-11-05

    The lifetimes at higher temperatures on lanthanum-modified lead titanate (PLT) are mainly due to the anharmonic decay of optical phonons into low-energy phonons. The temperature-independent contributions from inherent crystal defects and from boundary scattering become comparable to the phonon scattering contribution at lower temperatures. The thermal interaction is large at higher temperatures which decreases the phonon mean free path, and so the decay lifetime decreases as the temperature of the system is increased. This leads to the increased line width at higher temperatures. We made an estimate of the lifetimes for different concentrations and temperatures in PLT.

  10. The Lifetime of a beautiful and charming meson: B_c lifetime measured using the D0 detector

    SciTech Connect (OSTI)

    Welty-Rieger, Leah Christine; /Indiana U.

    2008-09-01

    Using approximately 1.3 fb{sup -1} of data collected by the D0 detector between 2002 and 2006, the lifetime of the B{sub c}{sup {+-}} meson is studied in the B{sub c}{sup {+-}} {yields} J/{psi}{mu}{sup {+-}} + X final state. Using an unbinned likelihood simultaneous fit to J/{psi} + {mu} invariant mass and lifetime distributions, a signal of 810 {+-} 80(stat.) candidates is estimated and a lifetime measurement made of: {tau}(B{sub c}{sup {+-}}) = 0.448{sub -0.036}{sup +0.038}(stat) {+-} 0.032(sys) ps.

  11. Measurement of the lifetimes of B meson mass eigenstates

    E-Print Network [OSTI]

    Anikeev, Konstantin

    2004-01-01

    In this dissertation, we present the results of the average lifetime measurements in ..., ..., and ... decays, as well as the results of a time-dependent angular analysis of ... and ... decays. The time-dependent angular ...

  12. A New World Average Value for the Neutron Lifetime

    E-Print Network [OSTI]

    A. P. Serebrov; A. K. Fomin

    2010-05-27

    The analysis of the data on measurements of the neutron lifetime is presented. A new most accurate result of the measurement of neutron lifetime [Phys. Lett. B 605 (2005) 72] 878.5 +/- 0.8 s differs from the world average value [Phys. Lett. B 667 (2008) 1] 885.7 +/- 0.8 s by 6.5 standard deviations. In this connection the analysis and Monte Carlo simulation of experiments [Phys. Lett. B 483 (2000) 15] and [Phys. Rev. Lett. 63 (1989) 593] is carried out. Systematic errors of about -6 s are found in each of the experiments. The summary table for the neutron lifetime measurements after corrections and additions is given. A new world average value for the neutron lifetime 879.9 +/- 0.9 s is presented.

  13. Societal lifetime cost of hydrogen fuel cell vehicles

    E-Print Network [OSTI]

    Sun, Yongling; Ogden, J; Delucchi, Mark

    2010-01-01

    gas emissions over the full fuel cycle and vehicle lifetime.are estimated over the full fuel cycle and entire vehicleoperation and maintenance, full fuel-cycle air-pollutant and

  14. Quantitative Characterization of Filament Dynamics by Single-Molecule Lifetime

    E-Print Network [OSTI]

    Needleman, Daniel

    CHAPTER 29 Quantitative Characterization of Filament Dynamics by Single-Molecule Lifetime University, Cambridge, Massachusetts 02138 Abstract I. Introduction to Cytoskeletal Filament Dynamics II III. Theoretical Foundations A. Equivalence to the First-Passage Time Problem B. Models of Filament

  15. Excess carrier lifetimes in Ge layers on Si

    SciTech Connect (OSTI)

    Geiger, R., E-mail: richard.geiger@psi.ch, E-mail: hans.sigg@psi.ch; Sigg, H., E-mail: richard.geiger@psi.ch, E-mail: hans.sigg@psi.ch [Laboratory for Micro- and Nanotechnology, Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Frigerio, J.; Chrastina, D.; Isella, G. [L-NESS, Dipartimento di Fisica del Politecnico di Milano, Via Anzani 42, 22100 Como (Italy); Süess, M. J. [Laboratory for Micro- and Nanotechnology, Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Laboratory for Nanometallurgy, Department of Materials Science, ETH Zurich, 8093 Zurich (Switzerland); Scientific Center for Optical and Electron Microscopy (SCOPEM), ETH Zurich, 8093 Zurich (Switzerland); Spolenak, R. [Laboratory for Nanometallurgy, Department of Materials Science, ETH Zurich, 8093 Zurich (Switzerland); Faist, J. [Institute for Quantum Electronics, ETH Zurich, 8093 Zurich (Switzerland)

    2014-02-10

    The excess charge carrier lifetimes in Ge layers grown on Si or germanium-on-insulator are measured by synchrotron based pump-probe transmission spectroscopy. We observe that the lifetimes do not strongly depend on growth parameters and annealing procedure, but on the doping profile. The defect layer at the Ge/Si interface is found to be the main non-radiative recombination channel. Therefore, the longest lifetimes in Ge/Si (2.6?ns) are achieved in sufficiently thick Ge layers with a built-in field, which repels electrons from the Ge/Si interface. Longer lifetimes (5.3?ns) are obtained in overgrown germanium-on-insulator due to the absence of the defective interface.

  16. Potential for Cardiovascular Exercise Dosing to Improve Cardiorespiratory Fitness in Breast Cancer Survivors

    E-Print Network [OSTI]

    Burnett, Dave

    2013-05-31

    With an increase in early detection and curative treatment for breast cancer, there is a growing number of breast cancer survivors. Cancer survivors are at greater risk than their age matched peers for long-term health ...

  17. Cancer Prognosis Through Gene Expression Analysis Steven Buechler, Applied and Computational Mathematics and Statistics,

    E-Print Network [OSTI]

    Buechler, Steven

    Cancer Prognosis Through Gene Expression Analysis Steven Buechler, Applied the breast cancer patients who can avoid chemotherapy without increasing the risk of recurrence. Background. Following the initial surgery, many breast cancer patients

  18. Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis

    E-Print Network [OSTI]

    Gerry, Arianna Aldridge

    2011-01-01

    treatment of primary breast cancer: A systematic review.Perceived risk of breast cancer among women at average and2003). Nutrition and breast cancer. Breast, 12, 412-416.

  19. Models for Battery Reliability and Lifetime: Applications in Design and Health Management (Presentation)

    SciTech Connect (OSTI)

    Smith, K.; Neubauer, J.; Wood, E.; Jun, M.; Pesaran, A.

    2013-06-01

    This presentation discusses models for battery reliability and lifetime and the Battery Ownership Model.

  20. Ultralong minority-carrier lifetime epitaxial GaAs by photon recycling

    SciTech Connect (OSTI)

    Ahrenkiel, R.K.; Dunlavy, D.J.; Keyes, B. (Solar Energy Research Institute, Golden, Colorado 80401 (US)); Vernon, S.M.; Dixon, T.M.; Tobin, S.P. (Spire Corporation, Bedford, Massachusetts 01730); Miller, K.L.; Hayes, R.E. (Department of Electrical and Computer Engineering, University of Colorado, Boulder, Colorado 80303)

    1989-09-11

    The minority-carrier lifetime has been measured by time-resolved photoluminescence in epitaxial films of GaAs grown by metalorganic chemical vapor deposition. The measured lifetimes in thicker devices are 4 to 6 times the theoretical or radiative lifetime. These long lifetimes are the result of photon recycling or self-generation of the self-absorbed radiation.

  1. doi:10.1016/j.ijrobp.2006.02.044 INDUCED SECOND CANCERS AFTER PROSTATE-CANCER

    E-Print Network [OSTI]

    Brenner, David Jonathan

    doi:10.1016/j.ijrobp.2006.02.044 EDITORIAL INDUCED SECOND CANCERS AFTER PROSTATE-CANCER University Medical Center, New York, NY The absolute risks of a radiation-induced second cancer among long concern, expressed by Kendal et al. (5) in this issue, that prostate cancer patients may be unduly

  2. SU-D-16A-01: A Novel Method to Estimate Normal Tissue Dose for Radiotherapy Patients to Support Epidemiologic Studies of Second Cancer Risk

    SciTech Connect (OSTI)

    Lee, C; Jung, J; Pelletier, C; Kim, J; Lee, C

    2014-06-01

    Purpose: Patient cohort of second cancer study often involves radiotherapy patients with no radiological images available: We developed methods to construct a realistic surrogate anatomy by using computational human phantoms. We tested this phantom images both in a commercial treatment planning system (Eclipse) and a custom Monte Carlo (MC) transport code. Methods: We used a reference adult male phantom defined by International Commission on Radiological Protection (ICRP). The hybrid phantom which was originally developed in Non-Uniform Rational B-Spline (NURBS) and polygon mesh format was converted into more common medical imaging format. Electron density was calculated from the material composition of the organs and tissues and then converted into DICOM format. The DICOM images were imported into the Eclipse system for treatment planning, and then the resulting DICOM-RT files were imported into the MC code for MC-based dose calculation. Normal tissue doses were calculation in Eclipse and MC code for an illustrative prostate treatment case and compared to each other. Results: DICOM images were generated from the adult male reference phantom. Densities and volumes of selected organs between the original phantom and ones represented within Eclipse showed good agreements, less than 0.6%. Mean dose from Eclipse and MC code match less than 7%, whereas maximum and minimum doses were different up to 45%. Conclusion: The methods established in this study will be useful for the reconstruction of organ dose to support epidemiological studies of second cancer in cancer survivors treated by radiotherapy. We also work on implementing body size-dependent computational phantoms to better represent patient's anatomy when the height and weight of patients are available.

  3. TOUSCHEK LIFETIME CALCULATIONS AND SIMULATIONS FOR NSLS-II

    SciTech Connect (OSTI)

    MONTAG,C.; BENGTSSON, J.; NASH, B.

    2007-06-25

    The beam lifetime in most medium energy synchrotron radiation sources is limited by the Touschek effect, which describes the momentum transfer from the transverse into the longitudinal direction due to binary collisions between electrons. While an analytical formula exists to calculate the resulting lifetime, the actual momentum acceptance necessary to perform this calculation can only be determined by tracking. This is especially the case in the presence of small vertical apertures at insertion devices. In this case, nonlinear betatron coupling leads to beam losses at these vertical aperture restrictions. In addition, a realistic model of the storage ring is necessary for calculation of equilibrium beam sizes (particularly in the vertical direction) which are important for a self-consistent lifetime calculation.

  4. Radiative lifetimes of metastable states of negative ions

    SciTech Connect (OSTI)

    Andersson, Pontus; Fritioff, Karin; Sandstroem, Joakim; Collins, Gerard; Hanstorp, Dag; Ellmann, Anna; Schef, Peter; Lundin, Peter; Mannervik, Sven; Royen, Peder; Froese Fischer, K. Charlotte; Oesterdahl, Fabian; Rostohar, Danijela; Pegg, David J.; Gibson, N. D.; Danared, Haakan; Kaellberg, Anders

    2006-03-15

    We present a technique for measuring the radiative lifetimes of metastable states of negative ions that involves the use of a heavy-ion storage ring. The method has been applied to investigate the radiative decay of the np{sup 3} {sup 2}P{sub 1/2} levels of Te{sup -}(n=5) and Se{sup -}(n=4) and the 3p{sup 3} {sup 2}D state of Si{sup -} for which the J=3/2 and 5/2 levels were unresolved. All of these states are metastable and decay primarily by emission of E2 and M1 radiation. Multi Configuration Dirac-Hartree-Fock calculations of rates for the transitions in Te{sup -} and Se{sup -} yielded lifetimes of 0.45 s and 4.7 s, respectively. The measured values agree well with these predicted values. In the case of the {sup 2}D state of Si{sup -}, however, our measurement was only able to set a lower limit on the lifetime. The upper limit of the lifetime that can be measured with our apparatus is set by how long the ions can be stored in the ring, a limit determined by the rate of collisional detachment. Our lower limit of 1 min for the lifetime of the {sup 2}D state is consistent with both the calculated lifetimes of 162 s for the {sup 2}D{sub 3/2} level and 27.3 h for the {sup 2}D{sub 5/2} level reported by O'Malley and Beck and 14.5 h and 12.5 h, respectively, from our Breit-Pauli calculations.

  5. Effect of Superalloy Substrate and Bond Coating on TBC Lifetime

    SciTech Connect (OSTI)

    Pint, Bruce A; Haynes, James A; Zhang, Ying

    2010-01-01

    Several different single-crystal superalloys were coated with different bond coatings to study the effect of composition on the cyclic oxidation lifetime of an yttria-stabilized zirconia (YSZ) top coating deposited by electron beam physical vapor deposition from a commercial source. Three different superalloys were coated with a 7 {micro}m Pt layer that was diffused into the surface prior to YSZ deposition. One of the superalloys, N5, was coated with a low activity, Pt-modified aluminide coating and Pt-diffusion coatings with 3 and 7 {micro}m of Pt. Three coatings of each type were furnace cycled to failure in 1 h cycles at 1150 C to assess average coating lifetime. The 7 {micro}m Pt diffusion coating on N5 had an average YSZ coating lifetime >50% higher than a Pt-modified aluminide coating on N5. Without a YSZ coating, the Pt-modified aluminide coating on N5 showed the typical surface deformation during cycling, however, the deformation was greatly reduced when constrained by the YSZ coating. The 3 {micro}m Pt diffusion coating had a similar average lifetime as the Pt-modified aluminide coating but a much wider scatter. The Pt diffusion bond coating on superalloy X4 containing Ti exhibited the shortest YSZ coating lifetime, this alloy-coating combination also showed the worst alumina scale adhesion without a YSZ coating. The third generation superalloy N6 exhibited the longest coating lifetime with a 7 {micro}m Pt diffusion coating.

  6. Risk assessment of soil-based exposures to plutonium at experimental sites located on the Nevada Test Site and adjoining areas

    SciTech Connect (OSTI)

    Layton, D.W.; Anspaugh, L.R.; Bogen, K.T.; Straume, T.

    1993-06-01

    In the late 1950s and early 1960s, a series of tests was conducted at or near the Nevada Test Site to study issues involving plutonium-bearing devices. These tests resulted in the dispersal of about 5 TBq of {sup 239,240}Pu on the surficial soils at the test locations. Access to the sites is strictly controlled; therefore, it does not constitute a threat to human health at the present time. However, because the residual {sup 239} Pu decays slowly (half-life of 24,110 y), the sites could indeed represent a long-term hazard if they are not remediated and if institutional controls are lost. To investigate the magnitude of the potential health risks for this no-remediation case, we defined three basic exposure scenarios that could bring individuals in contact with {sup 239,240}Pu at the sites: (1) a resident living in a subdivision located at a test site, (2) a resident farmer, and (3) a worker at a commercial facility. Our screening analyses indicated that doses to organs are dominated by the intemal deposition of Pu via the inhalation pathway, and thus our risk assessment focused on those factors that affect inhalation exposures and associated doses, including inhalation rates, activity patterns, tenure at a residence or occupation, indoor/outdoor air relationships, and resuspension outdoors. Cancer risks were calculated as a function of lifetime cumulative doses to the key target organs (i.e., bone surface, liver, and lungs) and risk factors for those organs. Uncertainties in the predicted cancer risks were analyzed using Monte-Carlo simulations of the probability distributions used to represent assessment parameters. The principal sources of uncertainty in the estimated risks were population mobility, the relationship between indoor and outdoor contaminant levels, and the dose and risk factors for bone, liver, and lung.

  7. CA-TSL: Energy Adaptation for Targeted System Lifetime in

    E-Print Network [OSTI]

    Singh, Jaswinder Pal

    are severely energy-constrained, and energy usage is one of the most common causes of failure. Although much work has focused on policies to reduce and regulate energy usage in fixed and dense networks lifetime in an intermittently connected system by adapting node energy usage to an estimated desired energy

  8. Precision measurement of the Lambda_b baryon lifetime

    E-Print Network [OSTI]

    LHCb collaboration; R. Aaij; B. Adeva; M. Adinolfi; C. Adrover; A. Affolder; Z. Ajaltouni; J. Albrecht; F. Alessio; M. Alexander; S. Ali; G. Alkhazov; P. Alvarez Cartelle; A. A. Alves Jr; S. Amato; S. Amerio; Y. Amhis; L. Anderlini; J. Anderson; R. Andreassen; J. E. Andrews; R. B. Appleby; O. Aquines Gutierrez; F. Archilli; A. Artamonov; M. Artuso; E. Aslanides; G. Auriemma; M. Baalouch; S. Bachmann; J. J. Back; C. Baesso; V. Balagura; W. Baldini; R. J. Barlow; C. Barschel; S. Barsuk; W. Barter; Th. Bauer; A. Bay; J. Beddow; F. Bedeschi; I. Bediaga; S. Belogurov; K. Belous; I. Belyaev; E. Ben-Haim; G. Bencivenni; S. Benson; J. Benton; A. Berezhnoy; R. Bernet; M. -O. Bettler; M. van Beuzekom; A. Bien; S. Bifani; T. Bird; A. Bizzeti; P. M. Bj\\ornstad; T. Blake; F. Blanc; J. Blouw; S. Blusk; V. Bocci; A. Bondar; N. Bondar; W. Bonivento; S. Borghi; A. Borgia; T. J. V. Bowcock; E. Bowen; C. Bozzi; T. Brambach; J. van den Brand; J. Bressieux; D. Brett; M. Britsch; T. Britton; N. H. Brook; H. Brown; I. Burducea; A. Bursche; G. Busetto; J. Buytaert; S. Cadeddu; O. Callot; M. Calvi; M. Calvo Gomez; A. Camboni; P. Campana; D. Campora Perez; A. Carbone; G. Carboni; R. Cardinale; A. Cardini; H. Carranza-Mejia; L. Carson; K. Carvalho Akiba; G. Casse; L. Castillo Garcia; M. Cattaneo; Ch. Cauet; R. Cenci; M. Charles; Ph. Charpentier; P. Chen; N. Chiapolini; M. Chrzaszcz; K. Ciba; X. Cid Vidal; G. Ciezarek; P. E. L. Clarke; M. Clemencic; H. V. Cliff; J. Closier; C. Coca; V. Coco; J. Cogan; E. Cogneras; P. Collins; A. Comerma-Montells; A. Contu; A. Cook; M. Coombes; S. Coquereau; G. Corti; B. Couturier; G. A. Cowan; D. C. Craik; S. Cunliffe; R. Currie; C. D'Ambrosio; P. David; P. N. Y. David; A. Davis; I. De Bonis; K. De Bruyn; S. De Capua; M. De Cian; J. M. De Miranda; L. De Paula; W. De Silva; P. De Simone; D. Decamp; M. Deckenhoff; L. Del Buono; N. Déléage; D. Derkach; O. Deschamps; F. Dettori; A. Di Canto; H. Dijkstra; M. Dogaru; S. Donleavy; F. Dordei; A. Dosil Suárez; D. Dossett; A. Dovbnya; F. Dupertuis; P. Durante; R. Dzhelyadin; A. Dziurda; A. Dzyuba; S. Easo; U. Egede; V. Egorychev; S. Eidelman; D. van Eijk; S. Eisenhardt; U. Eitschberger; R. Ekelhof; L. Eklund; I. El Rifai; Ch. Elsasser; A. Falabella; C. Färber; G. Fardell; C. Farinelli; S. Farry; D. Ferguson; V. Fernandez Albor; F. Ferreira Rodrigues; M. Ferro-Luzzi; S. Filippov; M. Fiore; C. Fitzpatrick; M. Fontana; F. Fontanelli; R. Forty; O. Francisco; M. Frank; C. Frei; M. Frosini; S. Furcas; E. Furfaro; A. Gallas Torreira; D. Galli; M. Gandelman; P. Gandini; Y. Gao; J. Garofoli; P. Garosi; J. Garra Tico; L. Garrido; C. Gaspar; R. Gauld; E. Gersabeck; M. Gersabeck; T. Gershon; Ph. Ghez; V. Gibson; L. Giubega; V. V. Gligorov; C. Göbel; D. Golubkov; A. Golutvin; A. Gomes; P. Gorbounov; H. Gordon; M. Grabalosa Gándara; R. Graciani Diaz; L. A. Granado Cardoso; E. Graugés; G. Graziani; A. Grecu; E. Greening; S. Gregson; P. Griffith; O. Grünberg; B. Gui; E. Gushchin; Yu. Guz; T. Gys; C. Hadjivasiliou; G. Haefeli; C. Haen; S. C. Haines; S. Hall; B. Hamilton; T. Hampson; S. Hansmann-Menzemer; N. Harnew; S. T. Harnew; J. Harrison; T. Hartmann; J. He; T. Head; V. Heijne; K. Hennessy; P. Henrard; J. A. Hernando Morata; E. van Herwijnen; A. Hicheur; E. Hicks; D. Hill; M. Hoballah; C. Hombach; P. Hopchev; W. Hulsbergen; P. Hunt; T. Huse; N. Hussain; D. Hutchcroft; D. Hynds; V. Iakovenko; M. Idzik; P. Ilten; R. Jacobsson; A. Jaeger; E. Jans; P. Jaton; A. Jawahery; F. Jing; M. John; D. Johnson; C. R. Jones; C. Joram; B. Jost; M. Kaballo; S. Kandybei; W. Kanso; M. Karacson; T. M. Karbach; I. R. Kenyon; T. Ketel; A. Keune; B. Khanji; O. Kochebina; I. Komarov; R. F. Koopman; P. Koppenburg; M. Korolev; A. Kozlinskiy; L. Kravchuk; K. Kreplin; M. Kreps; G. Krocker; P. Krokovny; F. Kruse; M. Kucharczyk; V. Kudryavtsev; T. Kvaratskheliya; V. N. La Thi; D. Lacarrere; G. Lafferty; A. Lai; D. Lambert; R. W. Lambert; E. Lanciotti; G. Lanfranchi; C. Langenbruch; T. Latham; C. Lazzeroni; R. Le Gac; J. van Leerdam; J. -P. Lees; R. Lefčvre; A. Leflat; J. Lefrançois; S. Leo; O. Leroy; T. Lesiak; B. Leverington; Y. Li; L. Li Gioi; M. Liles; R. Lindner; C. Linn; B. Liu; G. Liu; S. Lohn; I. Longstaff; J. H. Lopes; N. Lopez-March; H. Lu; D. Lucchesi; J. Luisier; H. Luo; F. Machefert; I. V. Machikhiliyan; F. Maciuc; O. Maev; S. Malde; G. Manca; G. Mancinelli; J. Maratas; U. Marconi; P. Marino; R. Märki; J. Marks; G. Martellotti; A. Martens; A. Martín Sánchez; M. Martinelli; D. Martinez Santos; D. Martins Tostes; A. Massafferri; R. Matev; Z. Mathe; C. Matteuzzi; E. Maurice; A. Mazurov; B. Mc Skelly; J. McCarthy; A. McNab; R. McNulty; B. Meadows; F. Meier; M. Meissner; M. Merk; D. A. Milanes; M. -N. Minard; J. Molina Rodriguez; S. Monteil; D. Moran; P. Morawski; A. Mordŕ; M. J. Morello; R. Mountain; I. Mous; F. Muheim; K. Müller; R. Muresan

    2013-07-31

    The ratio of the \\Lambda b baryon lifetime to that of the B0 meson is measured using 1.0/fb of integrated luminosity in 7 TeV center-of-mass energy pp collisions at the LHC. The \\Lambda b baryon is observed for the first time in the decay mode \\Lambda b -> J/\\psi pK-, while the B0 meson decay used is the well known B0 -> J/\\psi pi+K- mode, where the pi+ K- mass is consistent with that of the K*0(892) meson. The ratio of lifetimes is measured to be 0.976 +/- 0.012 +/- 0.006, in agreement with theoretical expectations based on the heavy quark expansion. Using previous determinations of the B0 meson lifetime, the \\Lambda b lifetime is found to be 1.482 +/- 0.018 +/- 0.012 ps. In both cases the first uncertainty is statistical and the second systematic.

  9. Maximizing Static Network Lifetime of Wireless Broadcast Adhoc Networks

    E-Print Network [OSTI]

    Poovendran, Radha

    of the important applications of wireless static adhoc net- works includes wireless sensor networks. The technology- cast routing over wireless static adhoc network where host mobility is not involved. We define the lifetime of a network as the dura- tion of time until the first node failure due to battery depletion. We

  10. Online Prediction of Battery Lifetime for Embedded and Mobile Devices

    E-Print Network [OSTI]

    Krintz, Chandra

    Online Prediction of Battery Lifetime for Embedded and Mobile Devices Ye Wen, Rich Wolski, and compare it to two similar battery prediction technologies: ACPI and Smart Battery. We employ twenty is a critical resource for battery-powered embedded systems and mobile devices. As such, battery life must

  11. General Network Lifetime and Cost Models for Evaluating Sensor Network

    E-Print Network [OSTI]

    Heinzelman, Wendi

    General Network Lifetime and Cost Models for Evaluating Sensor Network Deployment Strategies Zhao Cheng, Mark Perillo, and Wendi B. Heinzelman, Senior Member, IEEE Abstract--In multihop wireless sensor to energy imbalance among sensors often appear. Sensors closer to a data sink are usually required

  12. AIAA-2001-0025 SPECTRUM FATIGUE LIFETIME AND RESIDUAL STRENGTH

    E-Print Network [OSTI]

    on a typical fiberglass laminate configuration turbine blade fiberglass material has been undertaken under a variety of load sequences. Repeated block loading for the development of refined design tools. Present at two or more load levels as well as a modified standard design tools for estimating lifetimes

  13. The millennial atmospheric lifetime of anthropogenic CO2

    E-Print Network [OSTI]

    Cambridge, University of

    /ocean carbon cycle, which we review here. The largest fraction of the CO2 recovery will take place on time scales of centuries, as CO2 invades the ocean, but a significant fraction of the fossil fuel CO2, rangingThe millennial atmospheric lifetime of anthropogenic CO2 David Archer & Victor Brovkin Received: 19

  14. Environmental Aspects of Thin Film Module Production and Product Lifetime

    E-Print Network [OSTI]

    Bergman, Keren

    Impact #12;3 Thin-Film PV -The Triangle of SuccessThin-Film PV -The Triangle of Success Low Cost of Thin Film Module Production and Product Lifetime Vasilis Fthenakis PV Environmental Research Center@bnl.gov web: www.pv.bnl.gov www.clca.columbia.edu #12;2 PV Sustainability CriteriaPV Sustainability Criteria

  15. Fission life-time calculation using a complex absorbing potential

    E-Print Network [OSTI]

    Guillaume Scamps; Kouichi Hagino

    2015-12-28

    A comparison between the semi-classical approximation and the full quantum calculation with a complex absorbing potential is made with a model of the fission of 258Fm. The potential barrier is obtained with the constrained Skyrme HF+BCS theory. The life-time obtained by the two calculations agree with each other the difference being only by 25%.

  16. Link Lifetimes and Randomized Neighbor Selection in DHTs

    E-Print Network [OSTI]

    Yao, Zhongmei

    }@cs.tamu.edu Abstract--Several models of user churn, resilience, and link lifetime have recently appeared of the failed zone in the DHT space. To understand neighbor churn in such networks, this paper proposes a simple peer-to-peer (P2P) networks under user churn has recently attracted significant attention and has

  17. LUMINESCENCE LIFETIME INSTRUMENTATION DEVELOPMENT FOR MULTI-DYE ANALYSIS 

    E-Print Network [OSTI]

    Shadfan, Adam

    2011-08-08

    . These probes, or dyes, were platinum octaethyl porphyrin (PtOEP) and palladium (II)- 5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorphenyl)-porphyrin (PdTFPP). When oxygen has been purged from the dyes, the lifetimes of the dyes are approximately 90 ?s for Pt...

  18. Contribution of the PALB2 c.2323C>T [p. Q775X] Founder mutation in well-defined breast and/or ovarian cancer families and unselected ovarian cancer cases of French Canadian descent

    E-Print Network [OSTI]

    Tischkowitz, Marc; Sabbaghian, Nelly; Hamel, Nancy; Pouchet, Carly; Foulkes, William D.; Mes-Masson, Anne-Marie; Provencher, Diane M.; Tonin, Patricia N.

    2013-01-09

    -positive cases reported varied based on criteria of ascertainment of index cases tested. Although inherited PALB2 mutations are associated with increased risks of developing breast cancer, risk to ovarian cancer has not been fully explored in this demographically...

  19. HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Xu Ting [Institute of Clinical Pharmacology, Central South University, Changsha, Hunan (China) [Institute of Clinical Pharmacology, Central South University, Changsha, Hunan (China); Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei Qingyi [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lopez Guerra, Jose Luis [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States) [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Instituto Madrileno de Oncologia/Grupo IMO, Madrid (Spain); Wang Lie; Liu Zhensheng [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gomez, Daniel; O'Reilly, Michael; Lin, Steven Hsesheng [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang Yan [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Levy, Lawrence B. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhou Honghao [Institute of Clinical Pharmacology, Central South University, Changsha, Hunan (China)] [Institute of Clinical Pharmacology, Central South University, Changsha, Hunan (China); Liao Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2012-10-01

    Purpose: We investigated potential associations between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and overall survival in US patients with non-small cell lung cancer (NSCLC). Methods and Materials: Using available genomic DNA samples from 224 patients with NSCLC treated with definitive radio(chemo)therapy, we genotyped 2 SNPs of HSPB1 (NCBI SNP nos. rs2868370 and rs2868371). We used both Kaplan-Meier cumulative probability and Cox proportional hazards analyses to evaluate the effect of HSPB1 genotypes on survival. Results: Our cohort consisted of 117 men and 107 women, mostly white (79.5%), with a median age of 70 years. The median radiation dose was 66 Gy (range, 63-87.5 Gy), and 183 patients (82%) received concurrent platinum-based chemotherapy. The most common genotype of the rs2868371 SNP was CC (61%). Univariate and multivariate analyses showed that this genotype was associated with poorer survival than CG and GG genotypes (univariate hazard ratio [HR] = 1.39, 95% confidence interval [CI], 1.02-1.90; P=.037; multivariate HR = 1.39; 95% CI, 1.01-1.92; P=.045). Conclusions: Our results showed that the CC genotype of HSPB1 rs2868371 was associated with poorer overall survival in patients with NSCLC after radio(chemo)therapy, findings that contradict those of a previous study of Chinese patients. Validation of our findings with larger numbers of similar patients is needed, as are mechanical and clinical studies to determine the mechanism underlying these associations.

  20. Lifetime-dependent Battery Usage Optimization for Grid-Connected Residential Systems

    E-Print Network [OSTI]

    Simunic, Tajana

    utility energy prices. Our approach enables us determine the true operational cost and lifetimeLifetime-dependent Battery Usage Optimization for Grid-Connected Residential Systems Jagannathan Venkatesh# , Shengbo Chen* , Peerapol Tinnakornsrisuphap*, Tajana Simunic Rosing# # University of California

  1. Investigations of Game of Life cellular automata rules on Penrose Tilings: lifetime and ash

    E-Print Network [OSTI]

    Stepney, Susan

    Investigations of Game of Life cellular automata rules on Penrose Tilings: lifetime and ash; section 6 reports the statistics of lifetimes, ash densities, and growth of the region of activity. 2

  2. ISOTOPE, ELECTRIC FIELD, AND VIBRATIONAL STATE DEPENDENCE OF SINGLE ROTATIONAL LEVEL LIFETIMES OF S1 FORMALDEHYDE

    E-Print Network [OSTI]

    Weisshaar, James C.

    2012-01-01

    LEVEL LIFETIMES OF s 1 FORMALDEHYDE James C. Weisshaar andLEVEL LIFETIMES OF S SI FORMALDEHYDE James C. Weisshaara anda long history of s formaldehyde life- 1 • 2 Discrepancies

  3. Apparatus for measuring minority carrier lifetimes in semiconductor materials

    DOE Patents [OSTI]

    Ahrenkiel, Richard K. (Lakewood, CO)

    1999-01-01

    An apparatus for determining the minority carrier lifetime of a semiconductor sample includes a positioner for moving the sample relative to a coil. The coil is connected to a bridge circuit such that the impedance of one arm of the bridge circuit is varied as sample is positioned relative to the coil. The sample is positioned relative to the coil such that any change in the photoconductance of the sample created by illumination of the sample creates a linearly related change in the input impedance of the bridge circuit. In addition, the apparatus is calibrated to work at a fixed frequency so that the apparatus maintains a consistently high sensitivity and high linearly for samples of different sizes, shapes, and material properties. When a light source illuminates the sample, the impedance of the bridge circuit is altered as excess carriers are generated in the sample, thereby producing a measurable signal indicative of the minority carrier lifetimes or recombination rates of the sample.

  4. Lifetime statistics of quantum chaos studied by a multiscale analysis

    SciTech Connect (OSTI)

    Di Falco, A.; Krauss, T. F. [School of Physics and Astronomy, University of St. Andrews, North Haugh, St. Andrews, KY16 9SS (United Kingdom); Fratalocchi, A. [PRIMALIGHT, Faculty of Electrical Engineering, Applied Mathematics and Computational Science, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Saudi Arabia)

    2012-04-30

    In a series of pump and probe experiments, we study the lifetime statistics of a quantum chaotic resonator when the number of open channels is greater than one. Our design embeds a stadium billiard into a two dimensional photonic crystal realized on a silicon-on-insulator substrate. We calculate resonances through a multiscale procedure that combines energy landscape analysis and wavelet transforms. Experimental data is found to follow the universal predictions arising from random matrix theory with an excellent level of agreement.

  5. DISSERTATION IMPACT OF LIFETIME VARIATIONS AND SECONDARY BARRIERS ON

    E-Print Network [OSTI]

    Sites, James R.

    Te Solar-cell Performance The thin-film CdTe solar cell (generally n-CdS/p-CdTe) is one of the leading, where the best CdTe cells are about 250 mV below the best GaAs cells when an appropriate adjustmentDISSERTATION IMPACT OF LIFETIME VARIATIONS AND SECONDARY BARRIERS ON CdTe SOLAR-CELL PERFORMANCE

  6. Argon metastable dynamics and lifetimes in a direct current microdischarge

    SciTech Connect (OSTI)

    Stefanovi?, Ilija; Kuschel, Thomas; Schröter, Sandra; Böke, Marc

    2014-09-21

    In this paper we study the properties of a pulsed dc microdischarge with the continuous flow of argon. Argon metastable lifetimes are measured by tunable diode laser absorption spectroscopy (TDLAS) and are compared with calculated values which yield information about excitation and de-excitation processes. By increasing the gas flow-rate about 5 times from 10 to 50 sccm, the Ar{sup m} lifetime increases from 1 to 5 ?s due to the reduction of metastable quenching with gas impurities. Optical emission spectroscopy reveals nitrogen and water molecules as the main gas impurities. The estimated N? density [N?]=0.1% is too low to explain the measured metastable lifetimes. Water impurity was found to be the main de-excitation source of argon metastable atoms due to high quenching coefficients. The water impurity level of [H?O]=0.15% to 1% is sufficient to bring calculated metastable lifetimes in line with experiments. The maximum value of water content in the discharge compared to the argon atoms is estimated to approximately 6%, due to the large surface to volume ratio of the microdischarge. The current pulse releases the water molecules from the electrode surface and they are either re-adsorbed in the time between 0.4 ms for [H?O]=1% and 2.6 ms for [H?O]=0.15% or pumped out of the discharge with the speed equal to the gas flow-rate. Depending on its partial pressure, the water impurity re-adsorption time is of the order of magnitude or less then the argon gas residence time.

  7. He II Proximity Effect and the Lifetime of Quasars

    E-Print Network [OSTI]

    Khrykin, I S; McQuinn, M; Worseck, G

    2015-01-01

    The lifetime of quasars is fundamental for understanding the growth of supermassive black holes, and is an important ingredient in models of the reionization of the intergalactic medium. However, despite various attempts to determine quasar lifetimes, current estimates from a variety of methods are uncertain by orders of magnitude. This work combines cosmological hydrodynamical simulations and 1D radiative transfer to investigate the structure and evolution of the He II Ly$\\alpha$ proximity zones around quasars at $z \\simeq 3-4$. We show that the time evolution in the proximity zone can be described by a simple analytical model for the approach of the He II fraction $x_{\\rm HeII}\\left( t \\right)$ to ionization equilibrium, and use this picture to illustrate how the transmission profile depends on the quasar lifetime, quasar UV luminosity, and the ionization state of helium in the ambient IGM (i.e. the average He II fraction, or equivalently the metagalactic He II ionizing background). A significant degeneracy...

  8. Restrictions on the lifetime of sterile neutrinos from primordial nucleosynthesis

    SciTech Connect (OSTI)

    Ruchayskiy, Oleg [Physics Department, Theory Division, CERN, CH-1211 Geneva 23 (Switzerland); Ivashko, Artem, E-mail: oleg.ruchayskiy@epfl.ch, E-mail: ivashko@lorentz.leidenuniv.nl [Instituut-Lorentz for Theoretical Physics, Universiteit Leiden, Niels Bohrweg 2, Leiden (Netherlands)

    2012-10-01

    We analyze the influence of sterile neutrinos with the masses in the MeV range on the primordial abundances of Helium-4 and Deuterium. We solve explicitly the Boltzmann equations for all particle species, taking into account neutrino flavour oscillations and demonstrate that the abundances are sensitive mostly to the sterile neutrino lifetime and only weakly to the way the active-sterile mixing is distributed between flavours. The decay of these particles also perturbs the spectra of (decoupled) neutrinos and heats photons, changing the ratio of neutrino to photon energy density, that can be interpreted as extra neutrino species at the recombination epoch. We derive upper bounds on the lifetime of sterile neutrinos based on both astrophysical and cosmological measurements of Helium-4 and Deuterium. We also demonstrate that the recent results of Izotov and Thuan [1], who find 2? higher than predicted by the standard primordial nucleosynthesis value of Helium-4 abundance, are consistent with the presence in the plasma of sterile neutrinos with the lifetime 0.01–2 seconds.

  9. Biologically Effective Dose (BED) Correlation With Biochemical Control After Low-Dose Rate Prostate Brachytherapy for Clinically Low-Risk Prostate Cancer

    SciTech Connect (OSTI)

    Miles, Edward F.; Nelson, John W.; Alkaissi, Ali K.; Das, Shiva; Clough, Robert W.; Broadwater, Gloria; Anscher, Mitchell S.; Chino, Junzo P.; Oleson, James R.

    2010-05-01

    Purpose: To assess the correlation of postimplant dosimetric quantifiers with biochemical control of prostate cancer after low-dose rate brachytherapy. Methods and Materials: The biologically effective dose (BED), dose in Gray (Gy) to 90% of prostate (D{sub 90}), and percent volume of the prostate receiving 100% of the prescription dose (V{sub 100}) were calculated from the postimplant dose-volume histogram for 140 patients undergoing low-dose rate prostate brachytherapy from 1997 to 2003 at Durham Regional Hospital and the Durham VA Medical Center (Durham, NC). Results: The median follow-up was 50 months. There was a 7% biochemical failure rate (10 of 140), and 91% of patients (127 of 140) were alive at last clinical follow-up. The median BED was 148 Gy (range, 46-218 Gy). The median D{sub 90} was 139 Gy (range, 45-203 Gy). The median V{sub 100} was 85% (range, 44-100%). The overall 5-year biochemical relapse-free survival (bRFS) rate was 90.1%. On univariate Cox proportional hazards modeling, no pretreatment characteristic (Gleason score sum, age, baseline prostate-specific antigen, or clinical stage) was predictive of bRFS. The BED, D{sub 90}, and V{sub 100} were all highly correlated (Pearson coefficients >92%), and all were strongly correlated with bRFS. Using the Youden method, we identified the following cut points for predicting freedom from biochemical failure: D{sub 90} >= 110 Gy, V{sub 100} >= 74%, and BED >= 115 Gy. None of the covariates significantly predicted overall survival. Conclusions: We observed significant correlation between BED, D{sub 90}, and V{sub 100} with bRFS. The BED is at least as predictive of bRFS as D{sub 90} or V{sub 100}. Dosimetric quantifiers that account for heterogeneity in tumor location and dose distribution, tumor repopulation, and survival probability of tumor clonogens should be investigated.

  10. NEUTRON LIFETIME EXPERIMENT USING UCN STORAGE IN AN `ACCORDION-LIKE' TRAP

    E-Print Network [OSTI]

    Steyerl, Albert

    NEUTRON LIFETIME EXPERIMENT USING UCN STORAGE IN AN `ACCORDION-LIKE' TRAP BY ASHISH M. DESAI determination of the neutron lifetime has an impact on particle physics and cosmology. We report progress towards a measurement of the neutron lifetime using an accordion-like storage trap. Ultracold neutrons

  11. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three US population-based case-control studies of ovarian cancer

    SciTech Connect (OSTI)

    Whittemore, A.S.; Gong, G.; Itnyre, J.

    1997-03-01

    We investigate the familial risks of cancers of the breast and ovary, using data pooled from three population-based case-control studies of ovarian cancer that were conducted in the United States. We base estimates of the frequency of mutations of BRCA1 (and possibly other genes) on the reported occurrence of breast cancer and ovarian cancer in the mothers and sisters of 922 women with incident ovarian cancer (cases) and in 922 women with no history of ovarian cancer (controls). Segregation analysis and goodness-of-fit testing of genetic models suggest that rare mutations (frequency .0014; 95% confidence interval .0002-.011) account for all the observed aggregation of breast cancer and ovarian cancer in these families. The estimated risk of breast cancer by age 80 years is 73.5% in mutation carriers and 6.8% in noncarriers. The corresponding estimates for ovarian cancer are 27.8% in carriers and 1.8% in noncarriers. For cancer risk in carriers, these estimates are lower than those obtained from families selected for high cancer prevalence. The estimated proportion of all U.S. cancer diagnoses, by age 80 years, that are due to germ-line BRCA1 mutations is 3.0% for breast cancer and 4.4% for ovarian cancer. Aggregation of breast cancer and ovarian cancer was less evident in the families of 169 cases with borderline ovarian cancers than in the families of cases with invasive cancers. Familial aggregation did not differ by the ethnicity of the probands, although the number of non-White and Hispanic cases (N = 99) was sparse. 14 refs., 3 figs., 6 tabs.

  12. United States Environmental Protection Agency: Use of risk assessment and risk management methodologies. Master's thesis

    SciTech Connect (OSTI)

    Lamuro, R.J.

    1992-09-30

    Make a full investigation of the policy implications and appropriate uses of risk assessment and risk management in regulatory programs under various Federal laws to prevent cancer and other chronic health effects which may result from exposure to hazardous substances. This is the primary mission of the Risk Assessment and Management Commission (Risk Commission). The Clean Air Act Amendments of 1990 (CAAA), created the Risk Commission reflecting Congress' concern over agency use of risk assessment and risk management techniques and methodologies to implement federal laws protective of human health. The Risk Commission is to consider: methods for measuring and describing risks of chronic health effects from hazardous substances; methods to reflect uncertainties associated with estimation techniques, and whether it is possible or desirable to develop a consistent risk assessment methodology or a consistent standard of acceptable risk for various federal programs.

  13. Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in tourette syndrome

    E-Print Network [OSTI]

    2015-01-01

    McMahon, M.D. 7 ; Gholson J. Lyon, M.D. , Ph.D. 8 ; DanielleUtrecht, The Netherlands; G.J. Lyon, Stanley Institute forIllmann, King, Kurlan, Lee, Lyon, McMahon, Osiecki, Pauls,

  14. Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in tourette syndrome

    E-Print Network [OSTI]

    2015-01-01

    a Eating disorders Anorexia nervosa Comorbid disorder Sexa Eating disorders Anorexia nervosa Comorbid disorderdisorder Eating disorders Anorexia nervosa Bulimia nervosa b

  15. Markers of chemically induced cancer

    SciTech Connect (OSTI)

    Freeman, G.; Milman, H.A. (eds.)

    1984-01-01

    This book is a concise review and evaluation of available data for recognizing and measuring markers of cancer or oncogenesis provoked in vivo by chemicals using relatively short-term experiments in animals. This review focuses on biochemical and immunological changes that correlate with carcinogenicity. Such ''markers,'' if occurring early enough, may be used to predict the onset of cancer in experimental animals exposed to potential chemical carcinogens long before morphological changes are seen. It is by examining all the information available about the potential carcinogenicity of chemicals that proper decisions can be made towards limiting the risk of cancer due to exposure to chemical carcinogens.

  16. Lung Cancer . Author manuscript p16INK4A inactivation mechanisms in non-small-cell lung cancer patients

    E-Print Network [OSTI]

    Boyer, Edmond

    Lung Cancer . Author manuscript Page /1 10 p16INK4A inactivation mechanisms in non-small-cell lung occupational risk factor and that asbestos acts synergistically with tobacco smoking to induce lung cancer. Although some somatic gene alterations in lung cancer have been linked to tobacco smoke, few data

  17. Supervised Machine Learning Algorithms for Early Detection of Oral Epithelial Cancer Using Fluorescence Lifetime Imaging Microscopy 

    E-Print Network [OSTI]

    Lee, Joohyung

    2014-08-06

    fulfillment of the requirements for the degree of MASTER OF SCIENCE Chair of Committee, Jim Ji Co-Chair of Committee, Javier Jo Committee Members, Raffaella Righetti Sebastian Hoyos Head of Department, Chanan Singh August 2014 Major...

  18. Electron Beam Polarization Measurement Using Touschek Lifetime Technique

    SciTech Connect (OSTI)

    Sun, Changchun; /Duke U., DFELL; Li, Jingyi; /Duke U., DFELL; Mikhailov, Stepan; /Duke U., DFELL; Popov, Victor; /Duke U., DFELL; Wu, Wenzhong; /Duke U., DFELL; Wu, Ying; /Duke U., DFELL; Chao, Alex; /SLAC; Xu, Hong-liang; /Hefei, NSRL; Zhang, Jian-feng; /Hefei, NSRL

    2012-08-24

    Electron beam loss due to intra-beam scattering, the Touschek effect, in a storage ring depends on the electron beam polarization. The polarization of an electron beam can be determined from the difference in the Touschek lifetime compared with an unpolarized beam. In this paper, we report on a systematic experimental procedure recently developed at Duke FEL laboratory to study the radiative polarization of a stored electron beam. Using this technique, we have successfully observed the radiative polarization build-up of an electron beam in the Duke storage ring, and determined the equilibrium degree of polarization and the time constant of the polarization build-up process.

  19. Positron lifetime spectrometer using a DC positron beam

    DOE Patents [OSTI]

    Xu, Jun; Moxom, Jeremy

    2003-10-21

    An entrance grid is positioned in the incident beam path of a DC beam positron lifetime spectrometer. The electrical potential difference between the sample and the entrance grid provides simultaneous acceleration of both the primary positrons and the secondary electrons. The result is a reduction in the time spread induced by the energy distribution of the secondary electrons. In addition, the sample, sample holder, entrance grid, and entrance face of the multichannel plate electron detector assembly are made parallel to each other, and are arranged at a tilt angle to the axis of the positron beam to effectively separate the path of the secondary electrons from the path of the incident positrons.

  20. Phenomenology of Light Gauginos: I. Motivation, Masses, Lifetimes and Limits

    E-Print Network [OSTI]

    Glennys R. Farrar

    1995-08-14

    I explore an economical variant on supersymmetric standard models which may be indicated on cosmological grounds and is shown to have no SUSY-CP problem. Demanding radiative electroweak symmetry breaking suggests that the Higgs is light; other scalar masses may be ~ 100-200 GeV or less. In this case the gluino and photino, while massless at tree level, have 1-loop masses m(gluino) ~ 100 - 600 MeV and m(photino) ~ 100 - 1000 MeV. New hadrons with mass ~ 1 - 3 GeV are predicted and their lifetimes estimated. Existing experimental limits are discussed.

  1. Cosmological neutrino mass detection: The Best probe of neutrino lifetime

    SciTech Connect (OSTI)

    Serpico, Pasquale D.; /Fermilab

    2007-01-01

    Future cosmological data may be sensitive to the effects of a finite sum of neutrino masses even as small as {approx}0.06 eV, the lower limit guaranteed by neutrino oscillation experiments. We show that a cosmological detection of neutrino mass at that level would improve by many orders of magnitude the existing limits on neutrino lifetime, and as a consequence on neutrino secret interactions with (quasi-)massless particles as in majoron models. On the other hand, neutrino decay may provide a way-out to explain a discrepancy {approx}< 0.1 eV between cosmic neutrino bounds and Lab data.

  2. Origin of the Anomalous Long Lifetime of 14C

    SciTech Connect (OSTI)

    Dean, David Jarvis [ORNL; Nam, Hai Ah [ORNL; Maris, Pieter [Iowa State University; Vary, J. P. [Iowa State University; Navratil, Petr [Lawrence Livermore National Laboratory (LLNL); Ormand, W. Erich [Lawrence Livermore National Laboratory (LLNL)

    2011-01-01

    We report the microscopic origins of the anomalously suppressed beta decay of 14C to 14N using the ab initio no-core shell model with the Hamiltonian from the chiral effective field theory including three-nucleon force terms. The three-nucleon force induces unexpectedly large cancellations within the p shell between contributions to beta decay, which reduce the traditionally large contributions from the nucleon-nucleon interactions by an order of magnitude, leading to the long lifetime of 14C.

  3. Battery Lifetime Analysis and Simulation Tool (BLAST) Documentation

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield MunicipalTechnical Report:Speeding accessby a contractor ofvarDOEBattery Lifetime Analysis and

  4. Analysis of Senate Bill 961: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2010-01-01

    endometrial cancer, ovarian cancer, uterine cancer, andagents No Epithelial ovarian cancer, Hodgkins lymphomacancer, endometrial cancer, ovarian cancer, uterine sarcoma

  5. BREAST CANCER SUPPORT RESOURCES Smilow Cancer Hospital

    E-Print Network [OSTI]

    O'Hern, Corey S.

    BREAST CANCER SUPPORT RESOURCES Smilow Cancer Hospital · Early Stage Breast Cancer Support Group · Advanced Stage Cancer Support Group · IMPACT ­ Young Cancer Survivors' Group Contact: Angela Khairallah, LCSW at 203-200-2360 Reach to Recovery ­ American Cancer Society 1-800-227-2345 www.cancer.org Sisters

  6. Aging Impacts Transcriptome but not Genome of Hormone-dependentBreast Cancers

    SciTech Connect (OSTI)

    Yau, Christina; Fedele, Vita; Roydasgupta, Ritu; Fridlyand, Jane; Hubbard, Alan; Gray, Joe W.; Chew, Karen; Dairkee, Shanaz H.; Moore, DanH.; Schittulli, Francesco; Tommasi, Stefania; Paradiso, Angelo; Albertson, Donna G.; Benz, Christopher C.

    2007-10-09

    Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age-at-diagnosis has been shown to be an independent indicator of breast cancer prognosis. However, except for inherited forms of breast cancer, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior.

  7. Apparatus for measuring minority carrier lifetimes in semiconductor materials

    DOE Patents [OSTI]

    Ahrenkiel, R.K.

    1999-07-27

    An apparatus for determining the minority carrier lifetime of a semiconductor sample includes a positioner for moving the sample relative to a coil. The coil is connected to a bridge circuit such that the impedance of one arm of the bridge circuit is varied as sample is positioned relative to the coil. The sample is positioned relative to the coil such that any change in the photoconductance of the sample created by illumination of the sample creates a linearly related change in the input impedance of the bridge circuit. In addition, the apparatus is calibrated to work at a fixed frequency so that the apparatus maintains a consistently high sensitivity and high linearly for samples of different sizes, shapes, and material properties. When a light source illuminates the sample, the impedance of the bridge circuit is altered as excess carriers are generated in the sample, thereby producing a measurable signal indicative of the minority carrier lifetimes or recombination rates of the sample. 17 figs.

  8. Measurements of aperture and beam lifetime using movable beam scrapers in Indus-2 electron storage ring

    SciTech Connect (OSTI)

    Kumar, Pradeep; Ghodke, A. D.; Karnewar, A. K.; Holikatti, A. C.; Yadav, S.; Puntambekar, T. A.; Singh, G.; Singh, P.

    2013-12-15

    In this paper, the measurements of vertical and horizontal aperture which are available for stable beam motion in Indus-2 at beam energy 2.5 GeV using movable beam scrapers are presented. These beam scrapers are installed in one of the long straight sections in the ring. With the movement of beam scrapers towards the beam centre, the beam lifetime is measured. The beam lifetime data obtained from the movement of vertical and horizontal beam scrapers are analyzed. The contribution of beam loss due to beam-gas scattering (vacuum lifetime) and electron-electron scattering within a beam bunch (Touschek lifetime) is separated from the measured beam lifetime at different positions of the beam scrapers. Vertical and horizontal beam sizes at scrapers location are estimated from the scraper movement towards the beam centre in quantum lifetime limit and their values closely agree with measured value obtained using X-ray diagnostic beamline.

  9. Proton lifetime bounds from chirally symmetric lattice QCD

    E-Print Network [OSTI]

    Y. Aoki; P. Boyle; P. Cooney; L. Del Debbio; R. Kenway; C. M. Maynard; A. Soni; R. Tweedie

    2008-06-05

    We present results for the matrix elements relevant for proton decay in Grand Unified Theories (GUTs). The calculation is performed at a fixed lattice spacing a^{-1}=1.73(3) GeV using 2+1 flavors of domain wall fermions on lattices of size 16^3\\times32 and 24^3\\times64 with a fifth dimension of length 16. We use the indirect method which relies on an effective field theory description of proton decay, where we need to estimate the low energy constants, \\alpha = -0.0112(25) GeV^3 and \\beta = 0.0120(26) GeV^3. We relate these low energy constants to the proton decay matrix elements using leading order chiral perturbation theory. These can then be combined with experimental bounds on the proton lifetime to bound parameters of individual GUTs.

  10. Measurements of ultracold neutron lifetimes in solid deuterium

    E-Print Network [OSTI]

    C. L. Morris; J. M. Anaya; T. J. Bowles; B. W. Filippone; P. Geltenbort; R. E. Hill; M. Hino; S. Hoedl; G. E. Hogan; T. M. Ito; T. Kawai; K. Kirch; S. K. Lamoreaux; C. -Y. Liu; M. Makela; L. J. Marek; J. W. Martin; R. N. Mortensen; A. Pichlmaier; A. Saunders; S. J. Seestrom; D. Smith; W. Teasdale; B. Tipton; M. Utsuro; A. R. Young; J. Yuan

    2001-09-28

    We present the first measurements of the survival time of ultracold neutrons (UCNs) in solid deuterium SD2. This critical parameter provides a fundamental limitation to the effectiveness of superthermal UCN sources that utilize solid ortho-deuterium as the source material. Superthermal UCN sources offer orders of magnitude improvement in the available densities of UCNs, and are of great importance to fundamental particle-physics experiments such as searches for a static electric dipole moment and lifetime measurements of the free neutron. These measurements are performed utilizing a SD2 source coupled to a spallation source of neutrons, providing a demonstration of UCN production in this geometry and permitting systematic studies of the influence of thermal up-scatter and contamination with para-deuterium on the UCN survival time.

  11. Lifetime measurements of nuclei in few-electron ions

    E-Print Network [OSTI]

    Faestermann, Thomas

    2015-01-01

    In this review lifetime measurements of ions with at most two electrons are summarized. Such highly ionized systems have been studied - until now - only in the Experimental Storage Ring of the GSI in Darmstadt. Emphasis is put on decays via the weak interaction. The first observations of beta-decay into bound atomic states are described as well as its time mirrored counterpart, the electron-capture decay. In the latter case the decays of hydrogen- and helium-like ions are compared with a surprising result. Further on, the observation of sinusoidal modulations of the decay rate in two-body decays is summarized. As a possible cause an interference due to the emission of neutrinos with different rest mass is discussed.

  12. Atomistic Fracture and Nano-Macro Transition for Strength and Lifetime Statistics of Quasibrittle Structures

    E-Print Network [OSTI]

    Bazant, Martin Z.

    and lifetime distributions of quasibrittle structures. The theory is derived from the fracture mechanics materials, which include concrete, fiber composites, rocks, stiff cohesive soils, tough ceramics, rigid

  13. Risk Prioritization

    Energy Savers [EERE]

    Quality Managers Software Quality Assurance Subcommittee Reference Document SQAS21.01.00 - 1999 Software Risk Management A Practical Guide February, 2000 Abstract This document is...

  14. New methods for predicting lifetimes. Part 2 -- The Wear-out approach for predicting the remaining lifetime of materials

    SciTech Connect (OSTI)

    GILLEN,KENNETH T.; CELINA,MATHIAS C.

    2000-04-20

    The so-called Palmgren-Miner concept that degradation is cumulative, and that failure is therefore considered to be the direct result of the accumulation of damage with time, has been known for decades. Cumulative damage models based on this concept have been derived and used mainly for fatigue life predictions for metals and composite materials. The authors review the principles underlying such models and suggest ways in which they may be best applied to polymeric materials in temperature environments. The authors first consider cases where polymer degradation data can be rigorously time-temperature superposed over a given temperature range. For a step change in temperature after damage has occurred at an initial temperature in this range, they show that the remaining lifetime at the second temperature should be linearly related to the aging time prior to the step. This predicted linearity implies that it may be possible to estimate the remaining lifetime of polymeric materials aging under application ambient conditions by completing the aging at an accelerated temperature. They refer to this generic temperature-step method as the Wear-out approach. They then outline the expectations for Wear-out experiments when time-temperature superposition is invalid, specifically describing the two cases where so-called interaction effects are absent and are present. Finally, they present some preliminary results outlining the application of the Wear-out approach to polymers. In analyzing the experimental Wear-out results, they introduce a procedure that they refer to as time-damage superposition. This procedure not only utilizes all of the experimental data instead of a single point from each data set, but also allows them to determine the importance of any interaction effects.

  15. Throughput-Lifetime Tradeoffs in Multihop Wireless Networks under an SINR-based

    E-Print Network [OSTI]

    Rosenberg, Catherine P.

    1 Throughput-Lifetime Tradeoffs in Multihop Wireless Networks under an SINR-based Interference crucial design objectives for a number of multihop wireless network applica- tions. As these two this tradeoff between the network throughput and lifetime, for the case of fixed wireless networks where link

  16. SCHEDULING ABOVE MAC TO MAXIMIZE BATTERY LIFETIME AND THROUGHPUT IN WLANS

    E-Print Network [OSTI]

    Simunic, Tajana

    SCHEDULING ABOVE MAC TO MAXIMIZE BATTERY LIFETIME AND THROUGHPUT IN WLANS Edoardo Regini, Daeseob Diego La Jolla, CA 92093 {eregini, dalim, tajana}@ucsd.edu ABSTRACT Maximizing battery lifetime. This is because in heavy traffic conditions, the chance of nodes to successfully transmit a packet decreases

  17. NEWS REPORT William L. Ogren was honored with a Lifetime Achievement

    E-Print Network [OSTI]

    Govindjee

    is a brief description of the 2010 Lifetime Achievement Award received by William (Bill) L. Ogren from; William Lucas, University of California at Davis; Harald Paulsen, Johannes Gutenberg University MainzNEWS REPORT William L. Ogren was honored with a Lifetime Achievement Award by the Rebeiz Foundation

  18. Ris-R-1515(EN) Lifetime Modelling of Lead Acid Batteries

    E-Print Network [OSTI]

    Risř-R-1515(EN) Lifetime Modelling of Lead Acid Batteries Henrik Bindner, Tom Cronin, Per Lundsager Baring-Gould Title: Lifetime Modelling of Lead Acid Batteries Department: VEA, VES Risř-R-1515 April 2005 storage in batteries are an important part of many renewable based energy systems. Not only do batteries

  19. SO2 emissions and lifetimes: Estimates from inverse modeling using in situ and global, spacebased

    E-Print Network [OSTI]

    Dickerson, Russell R.

    SO2 emissions and lifetimes: Estimates from inverse modeling using in situ and global, spacebased 18 March 2011. [1] Topdown constraints on global sulfur dioxide (SO2) emissions are inferred through of GEOSChem for inversion of SO2 columns to emissions. The seasonal mean SO2 lifetime calculated with the GEOS

  20. Minimizing Energy and Maximizing Network Lifetime Multicasting in Wireless Ad Hoc Networks

    E-Print Network [OSTI]

    Liang, Weifa

    Minimizing Energy and Maximizing Network Lifetime Multicasting in Wireless Ad Hoc Networks Weifa Abstract-- Most mobile nodes in a wireless ad hoc network are powered by energy limited batteries, the limited battery lifetime imposes a constraint on the network performance. Therefore, energy efficiency

  1. Quantitative Fluorescence Microscopy autofocusing, z-axis calibration, image sensors, fluorescence lifetime imaging

    E-Print Network [OSTI]

    van Vliet, Lucas J.

    Prof. dr ir A. van den Bos, Technische Universiteit Delft Prof. dr H.J. Tanke, Rijksuniversiteit Leiden of ideas and concepts that other people have set out for you. Now it is your turn. You get to design lifetime calculation 124 Dual-lifetime estimators 127 Materials and methods 130 Calibration of the FLIM

  2. Vibrational Lifetimes and Spectral Shifts in Supercritical Fluids as a Function of Density: Experiments and Theory

    E-Print Network [OSTI]

    Fayer, Michael D.

    (CO2) as a function of density from low density (well below the critical density) to high densityVibrational Lifetimes and Spectral Shifts in Supercritical Fluids as a Function of Density Vibrational lifetime and spectral shift data for the asymmetric CO stretching mode of W(CO)6 in supercritical

  3. Environment and the Lifetime of Tropical Deep Convection in a Cloud-Permitting Regional Model Simulation

    SciTech Connect (OSTI)

    Hagos, Samson M.; Feng, Zhe; McFarlane, Sally A.; Leung, Lai-Yung R.

    2013-08-01

    By applying a cloud tracking algorithm to tropical convective systems simulated by a regional high resolution model, the study documents environmental conditions before and after convective systems are initiated over ocean and land by following them during their lifetime. The comparative roles of various environmental fields in affecting the lifetime of convection are also quantified. The statistics of lifetime, maximum area, propagation speed and direction of the simulated deep convection agrees well with geostationary satellite observations. Over ocean, convective systems enhance surface fluxes through the associated wind gusts as well as cooling and drying of the boundary layer. A significant relationship is found between the mean surface fluxes during their lifetime and the longevity of the systems which in turn is related to the initial intensity of the moist updraft and to a lesser extent upper level shear. Over land, on the other hand, convective activity suppresses surface fluxes through cloud cover and the lifetime of convection is related to the upper level shear during their lifetime and strength of the heat fluxes several hours before the initiation of convection. For systems of equal lifetime, those over land are significantly more intense than those over ocean especially during early stages of their lifetime.

  4. Enterprise Risk Management Program

    E-Print Network [OSTI]

    Hayden, Nancy J.

    Enterprise Risk Management Program DRAFT Introduction to Enterprise Risk Management at UVM 1 #12;Enterprise Risk Management Program DRAFT What is Enterprise Risk Management? Enterprise risk management governance, and accountability · Facilitates effective management of the uncertainty and associated risks

  5. The Ideal Evaluation of a Risk Prediction Model: A Randomized Clinical Trial

    E-Print Network [OSTI]

    Brent, Roger

    The Ideal Evaluation of a Risk Prediction Model: A Randomized Clinical Trial Holly Janes Fred Hutchinson Cancer Research Center 1/25 #12;Context Often a risk prediction model is developed to identify high risk subjects who can benefit from preventative therapy E.g. Framingham risk model to identify

  6. Risk Management under Liquidity Risk: Liquidity inclusive Risk Measures

    E-Print Network [OSTI]

    Brigo, Damiano

    Risk Management under Liquidity Risk: Liquidity inclusive Risk Measures GARP Seminar, London, Nov://www.capco.com/capco-insights -- Joint work with Claudio Nordio Prof. D. Brigo (Imperial College and Capco) Risk Management under Management under Liquidity Risk GARP Seminar London 2 / 60 #12;Introduction Liquidity in Risk Measurement

  7. Lifetime measurements in {sup 63}Co and {sup 65}Co

    SciTech Connect (OSTI)

    Dijon, A.; Clement, E.; France, G. de; Van Isacker, P.; Rejmund, M.; Schmitt, C.; Goergen, A.; Obertelli, A.; Korten, W.; Dewald, A.; Hackstein, M.; Pissulla, Th.; Rother, W.; Zell, K. O.; Gadea, A.; Gaudefroy, L.; Mengoni, D.; Recchia, F.; Sahin, E.

    2011-06-15

    Lifetimes of the 9/2{sub 1}{sup -} and 3/2{sub 1}{sup -} states in {sup 63}Co and the 9/2{sub 1}{sup -} state in {sup 65}Co were measured using the recoil distance Doppler shift and the differential decay curve methods. The nuclei were populated by multinucleon transfer reactions in inverse kinematics. {gamma} rays were measured with the EXOGAM Ge array and the recoiling fragments were fully identified using the large-acceptance VAMOS spectrometer. The E2 transition probabilities from the 3/2{sub 1}{sup -} and 9/2{sub 1}{sup -} states to the 7/2{sup -} ground state could be extracted in {sup 63}Co as well as an upper limit for the 9/2{sub 1}{sup -}{yields}7/2{sub 1}{sup -} B(E2) value in {sup 65}Co. The experimental results were compared to large-scale shell-model calculations in the pf and pfg{sub 9/2} model spaces, allowing us to draw conclusions on the single-particle or collective nature of the various states.

  8. Accelerated stress rupture lifetime assessment for fiber composites

    SciTech Connect (OSTI)

    Groves, S.E.; DeTeresa, S.J.; Sanchez, R.J.; Zocher, M.A.; Christensen, R.M.

    1997-02-01

    Objective was to develop a theoretical and experimental framework for predicting stress rupture lifetime for fiber polymer composites based on short-term accelerated testing. Originally a 3-year project, it was terminated after the first year, which included stress rupture experiments and viscoelastic material characterization. In principle, higher temperature, stress, and saturated environmental conditions are used to accelerate stress rupture. Two types of specimens were to be subjected to long-term and accelerated static tensile loading at various temperatures, loads in order to quantify both fiber and matrix dominated failures. Also, we were to apply state-of-the-art analytical and experimental characterization techniques developed under a previous DOE/DP CRADA for capturing and tracking incipient degradation mechanisms associated with mechanical performance. Focus was increase our confidence to design, analyze, and build long-term composite structures such as flywheels and hydrogen gas storage vessels; other applications include advanced conventional weapons, infrastructures, marine and offshore systems, and stockpile stewardship and surveillance. Capabilities developed under this project, though not completed or verified, are being applied to NIF, AVLIS, and SSMP programs.

  9. Analysis of Assembly Bill 1000: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    endometrial cancer, ovarian cancer, uterine cancer, andagents No Epithelial ovarian cancer, melanoma, multiplein advanced, inoperable ovarian cancer; used as palliative

  10. On the low carrier lifetime edge zone in multicrystalline silicon ingots

    SciTech Connect (OSTI)

    Jiang, Tingting; Yu, Xuegong; Wang, Lei; Gu, Xin; Yang, Deren, E-mail: mseyang@zju.edu.cn [State Key Laboratory of Silicon Materials and Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027 (China)

    2014-01-07

    We have demonstrated the cause of low minority carrier lifetime corresponding to the edge zone of casting multicrystalline silicon ingots and its influence on the performance of solar cells. It is found that the concentration of substitutional carbon, interstitial oxygen, and dislocation density have no direct correlation with the low minority carrier lifetime in the edge zone. However, the distribution of interstitial iron exactly coincides with the minority carrier lifetime, indicating that iron contamination is mainly responsible for the lifetime degradation. After phosphorus diffusion gettering process, the low carrier lifetime region became narrower, and the concentration of interstitial iron is reduced by almost one order of magnitude. However, the carrier lifetime in the edge zone cannot be raised to average level. After celling process, the internal quantum efficiency map of the edge zone has a lower response to the long wavelength light, in accordance with the minority carrier lifetime distribution in this region. Therefore, the solar cells based on edge zones exhibit slightly lower efficiency than those conventional ones.

  11. Los Alamos National Laboratory W76 Pit Tube Lifetime Study

    SciTech Connect (OSTI)

    Abeln, Terri G.

    2012-04-25

    A metallurgical study was requested as part of the Los Alamos National Laboratory (LANL) W76-1 life-extension program (LEP) involving a lifetime analysis of type 304 stainless steel pit tubes subject to repeat bending loads during assembly and disassembly operations at BWXT/Pantex. This initial test phase was completed during the calendar years of 2004-2006 and the report not issued until additional recommended tests could be performed. These tests have not been funded to this date and therefore this report is considered final. Tubes were reportedly fabricated according to Rocky Flats specification P14548 - Seamless Type 304 VIM/VAR Stainless Steel Tubing. Tube diameter was specified as 0.125 inches and wall thickness as 0.028 inches. A heat treat condition is not specified and the hardness range specification can be characteristic of both 1/8 and 1/4 hard conditions. Properties of all tubes tested were within specification. Metallographic analysis could not conclusively determine a specified limit to number of bends allowable. A statistical analysis suggests a range of 5-7 bends with a 99.95% confidence limit. See the 'Statistical Analysis' section of this report. The initial phase of this study involved two separate sets of test specimens. The first group was part of an investigation originating in the ESA-GTS [now Gas Transfer Systems (W-7) Group]. After the bend cycle test parameters were chosen (all three required bends subjected to the same amount of bend cycles) and the tubes bent, the investigation was transferred to Terri Abeln (Metallurgical Science and Engineering) for analysis. Subsequently, another limited quantity of tubes became available for testing and were cycled with the same bending fixture, but with different test parameters determined by T. Abeln.

  12. Detection of Atherosclerotic Coronary Plaques by Fluorescence Lifetime Imaging Angioscopy 

    E-Print Network [OSTI]

    Thomas, Patrick A.

    2010-10-12

    of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, Javier Jo Committee Members, Fred Clubb Kristen Maitland Head of Department, Gerard Cote... of Advisory Committee: Dr. Javier Jo Vulnerable plaque is a clinically silent condition of atherosclerotic plaque that leaves a large number of patients at risk of a coronary event. A method to detect vulnerable atherosclerotic plaque would greatly...

  13. New Tool Quantitatively Maps Minority-Carrier Lifetime of Multicrystalline Silicon Bricks (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2011-11-01

    NREL's new imaging tool could provide manufacturers with insight on their processes. Scientists at the National Renewable Energy Laboratory (NREL) have used capabilities within the Process Development and Integration Laboratory (PDIL) to generate quantitative minority-carrier lifetime maps of multicrystalline silicon (mc-Si) bricks. This feat has been accomplished by using the PDIL's photoluminescence (PL) imaging system in conjunction with transient lifetime measurements obtained using a custom NREL-designed resonance-coupled photoconductive decay (RCPCD) system. PL imaging can obtain rapid high-resolution images that provide a qualitative assessment of the material lifetime-with the lifetime proportional to the pixel intensity. In contrast, the RCPCD technique provides a fast quantitative measure of the lifetime with a lower resolution and penetrates millimeters into the mc-Si brick, providing information on bulk lifetimes and material quality. This technique contrasts with commercially available minority-carrier lifetime mapping systems that use microwave conductivity measurements. Such measurements are dominated by surface recombination and lack information on the material quality within the bulk of the brick. By combining these two complementary techniques, we obtain high-resolution lifetime maps at very fast data acquisition times-attributes necessary for a production-based diagnostic tool. These bulk lifetime measurements provide manufacturers with invaluable feedback on their silicon ingot casting processes. NREL has been applying the PL images of lifetime in mc-Si bricks in collaboration with a U.S. photovoltaic industry partner through Recovery Act Funded Project ARRA T24. NREL developed a new tool to quantitatively map minority-carrier lifetime of multicrystalline silicon bricks by using photoluminescence imaging in conjunction with resonance-coupled photoconductive decay measurements. Researchers are not hindered by surface recombination and can look deeper into the material to map bulk lifetimes. The tool is being applied to silicon bricks in a project collaborating with a U.S. photovoltaic industry partner. Photovoltaic manufacturers can use the NREL tool to obtain valuable feedback on their silicon ingot casting processes.

  14. Advanced Models and Controls for Prediction and Extension of Battery Lifetime (Presentation)

    SciTech Connect (OSTI)

    Smith, K.; Wood, E.; Santhanagopalan, S.; Kim, G.; Pesaran, A.

    2014-02-01

    Predictive models of capacity and power fade must consider a multiplicity of degradation modes experienced by Li-ion batteries in the automotive environment. Lacking accurate models and tests, lifetime uncertainty must presently be absorbed by overdesign and excess warranty costs. To reduce these costs and extend life, degradation models are under development that predict lifetime more accurately and with less test data. The lifetime models provide engineering feedback for cell, pack and system designs and are being incorporated into real-time control strategies.

  15. Measurement of the B-cmeson lifetime in the decay B-c?J/???

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Aaltonen, T.; Álvarez González, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J. A.; Arisawa, T.; et al

    2013-01-02

    The lifetime of the B-c meson is measured using 272 exclusive B-c?J/?(?????)?? decays reconstructed in data from proton-antiproton collisions corresponding to an integrated luminosity of 6.7 fb?ą recorded by the CDF II detector at the Fermilab Tevatron. The lifetime of the B-cmeson is measured to be ?(B-c)=0.452±0.048(stat)±0.027(syst) ps. This is the first measurement of the B-c meson lifetime in a fully reconstructed hadronic channel, and it agrees with previous results and has comparable precision.

  16. Calculation of the extinction cross section and lifetime of a gold nanoparticle using FDTD simulations

    SciTech Connect (OSTI)

    Radhakrishnan, Archana, E-mail: anju.archana@gmail.com [B.Tech, Engineering Physics, National Institute Of Technology, Calicut (India); Murugesan, Dr V., E-mail: murugesh@serc.iisc.in [Assistant Professor, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore (India)

    2014-10-15

    The electromagnetic theory of light explains the behavior of light in most of the domains quite accurately. The problem arises when the exact solution of the Maxwell's equation is not present, in case of objects with arbitrary geometry. To find the extinction cross-section and lifetime of the gold nanoparticle, the software FDTD solutions 8.6 by Lumerical is employed. The extinction cross-sections and lifetimes of Gold nanospheres of different sizes and arrangements are studied using pulse lengths of the order of femtoseconds. The decay constant and other properties are compared. Further, the lifetimes are calculated using frequency and time domain calculations.

  17. Exciton Lifetime Paradoxically Enhanced by Dissipation and Decoherence - Toward Efficient Energy Conversion of Solar Cell

    E-Print Network [OSTI]

    Yasuhiro Yamada; Youhei Yamaji; Masatoshi Imada

    2015-02-25

    Energy dissipation and decoherence are at first glance harmful to acquiring long exciton lifetime desired for efficient photovoltaics. In the presence of both optically forbidden (namely, dark) and allowed (bright) excitons, however, they can be instrumental as suggested in photosynthesis. By simulating quantum dynamics of exciton relaxations, we show that the optimized decoherence that imposes a quantum-to-classical crossover with the dissipation realizes a dramatically longer lifetime. In an example of carbon nanotube, the exciton lifetime increases by nearly two orders of magnitude when the crossover triggers stable high population in the dark exciton.

  18. Exciton Lifetime Paradoxically Enhanced by Dissipation and Decoherence - Toward Efficient Energy Conversion of Solar Cell

    E-Print Network [OSTI]

    Yamada, Yasuhiro; Imada, Masatoshi

    2015-01-01

    Energy dissipation and decoherence are at first glance harmful to acquiring long exciton lifetime desired for efficient photovoltaics. In the presence of both optically forbidden (namely, dark) and allowed (bright) excitons, however, they can be instrumental as suggested in photosynthesis. By simulating quantum dynamics of exciton relaxations, we show that the optimized decoherence that imposes a quantum-to-classical crossover with the dissipation realizes a dramatically longer lifetime. In an example of carbon nanotube, the exciton lifetime increases by nearly two orders of magnitude when the crossover triggers stable high population in the dark exciton.

  19. Generation and Recombination Carrier Lifetimes in 4H SiC Epitaxial Wafers , M. J. Loboda1)

    E-Print Network [OSTI]

    Schroder, Dieter K.

    Generation and Recombination Carrier Lifetimes in 4H SiC Epitaxial Wafers G. Chung1) , M. J. Loboda comparative studies of recombination and carrier lifetimes in SiC. For the first time, both generation-wafer structures. The ratio of the generation to recombination lifetime is much different in SiC compared to Si

  20. www.yalecancercenter.org Coping with a Breast Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    rates of breast cancer. However, Asians who migrate and live in the United States have a higher rate are not at risk of breast cancer. It's a very common disease and in the United States at this time almost one out the fact that the incidence has been increasing, the death rate for most of the last century has remained

  1. Nutr Cancer . Author manuscript Freeze-dried ham promotes azoxymethane-induced mucin-depleted foci

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Nutr Cancer . Author manuscript Page /1 9 Freeze-dried ham promotes azoxymethane-induced mucin and red meat consumption is associated with the risk of colorectal cancer. Meta-analyses have suggested that the risk associated with processed meat is higher. Most processed meats are cured and cooked, which leads

  2. Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer

    E-Print Network [OSTI]

    Aickelin, Uwe

    1 Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer , IO Ellis*1,4 1 Breast Cancer Pathology Research Group, Division of Oncology, School of Medicine and 2: Nottingham Prognostic Index Plus #12;2 Abstract Current management of breast cancer (BC) relies on risk

  3. Breast Cancer Research and Treatment 75: 147157, 2002. 2002 Kluwer Academic Publishers. Printed in the Netherlands.

    E-Print Network [OSTI]

    Apkarian, A. Vania

    Breast Cancer Research and Treatment 75: 147­157, 2002. © 2002 Kluwer Academic Publishers. Printed-MPQ) for the measurement of mastalgia, and have administered it to 271 women with breast pain and without breast cancer these differences, particularly with regard to a possible connection with breast cancer risk. Introduction Mastalgia

  4. Breast Cancer and Biomedical Informatics: The PrognoChip Project G. Potamias1,2

    E-Print Network [OSTI]

    Analyti, Anastasia

    Breast Cancer and Biomedical Informatics: The PrognoChip Project G. Potamias1,2 *, A. Analyti1 , D, Greece, 6 Prolipsis Diagnostic Breast Center, Athens, Greece. Abstract - Breast cancer is the most common malignancy affecting women, the life time risk being approximately 10%. Breast cancer is both genetically

  5. An Admixture Scan in 1,484 African American Women with Breast Cancer

    E-Print Network [OSTI]

    Reich, David

    An Admixture Scan in 1,484 African American Women with Breast Cancer Laura Fejerman,1 Christopher A women with breast cancer present more commonly with aggressive tumors that do not ex- press the estrogen-wide scan to search for risk alleles for breast cancer that are highly differentiated in fre- quency between

  6. Sacrificial high-temperature phosphorus diffusion gettering for lifetime improvement of multicrystalline silicon wafers

    E-Print Network [OSTI]

    Scott, Stephanie Morgan

    2014-01-01

    Iron is among the most deleterious lifetime-limiting impurities in crystalline silicon solar cells. In as-grown material, iron is present in precipitates and in point defects. To achieve conversion efficiencies in excess ...

  7. Effective lifetimes exceeding 300 ?s in gettered p-type epitaxial kerfless silicon for photovoltaics

    E-Print Network [OSTI]

    Powell, D. M.

    We evaluate defect concentrations and investigate the lifetime potential of p-type single-crystal kerfless silicon produced via epitaxy for photovoltaics. In gettered material, low interstitial iron concentrations (as low ...

  8. Volume163,number 4,5 CHEMICALPHYSICSLETTERS 17November 1989 EXPERIMENTAL MEASUREMENT OF THE RADIATIVE LIFETIME

    E-Print Network [OSTI]

    OF THE RADIATIVE LIFETIME OF NO+(X%+, v=l, 2 AND 3) C.-H. KUO, C.G. BEGGS, P.R. KEMPER, M.T. BOWERS ' Department

  9. Norwegian National Program for Lifetime Commissioning and Energy Efficient Operation of Buildings 

    E-Print Network [OSTI]

    Novakovic, V.; Djuric, N.; Holst, J.; Frydenlund, F.

    2006-01-01

    The project “Life-Time Commissioning for Energy Efficient Operation of Buildings” is actually a network of industrial companies, private and public entities, and R&D organizations. The overall objective of the project is to contribute...

  10. Measurement of the ?[superscript 0 over subscript b] lifetime and mass in the ATLAS experiment

    E-Print Network [OSTI]

    Taylor, Frank E.

    A measurement of the ?[superscript 0 over subscript b] lifetime and mass in the decay channel ?[superscript 0 over subscript b]?J/?(?[superscript +]?[superscript -])?[superscript 0](p?[superscript -]) is presented. The ...

  11. The Application of Fluorescence Lifetime Imaging Microscopy to Quantitatively Map Mixing and Temperature in Microfluidic Systems 

    E-Print Network [OSTI]

    Graham, Emmelyn M

    2008-01-01

    The technique of Fluorescence Lifetime Imaging Microscopy (FLIM) has been employed to quantitatively and spatially map the fluid composition and temperature within microfluidic systems. A molecular probe with a ...

  12. Lifetime measurements of high-lying short lived states in {sup 69}As

    SciTech Connect (OSTI)

    Matejska-Minda, M.; Bednarczyk, P.; Fornal, B.; Ciemala, M.; Kmiecik, M.; Krzysiek, M.; Maj, A.; Meczynski, W.; Myalski, S.; Styczen, J.; Zieblinski, M.; Angelis, G. de; Huyuk, T.; Michelagnoli, C.; Sahin, E.; Aydin, S.; Farnea, E.; Menegazzo, R.; Recchia, F.; Ur, C. A.; and others

    2012-10-20

    Lifetimes of high-spin states in {sup 69}As have been measured using Doppler shift attenuation technique with the GASP and RFD setup. The determined transition probabilities indicate large deformation associated with some rotational bands in this nucleus.

  13. A portable time-domain LED fluorimeter for nanosecond fluorescence lifetime measurements

    SciTech Connect (OSTI)

    Wang, Hongtao; Salthouse, Christopher D., E-mail: salthouse@ecs.umass.edu [Electrical and Computer Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003 (United States); Center for Personalized Health Monitoring, University of Massachusetts, Amherst, Massachusetts 01003 (United States); Qi, Ying; Mountziaris, T. J. [Center for Personalized Health Monitoring, University of Massachusetts, Amherst, Massachusetts 01003 (United States) [Center for Personalized Health Monitoring, University of Massachusetts, Amherst, Massachusetts 01003 (United States); Chemical Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003 (United States)

    2014-05-15

    Fluorescence lifetime measurements are becoming increasingly important in chemical and biological research. Time-domain lifetime measurements offer fluorescence multiplexing and improved handling of interferers compared with the frequency-domain technique. In this paper, an all solid-state, filterless, and highly portable light-emitting-diode based time-domain fluorimeter (LED TDF) is reported for the measurement of nanosecond fluorescence lifetimes. LED based excitation provides more wavelengths options compared to laser diode based excitation, but the excitation is less effective due to the uncollimated beam, less optical power, and longer latency in state transition. Pulse triggering and pre-bias techniques were implemented in our LED TDF to improve the peak optical power to over 100 mW. The proposed pulsing circuit achieved an excitation light fall time of less than 2 ns. Electrical resetting technique realized a time-gated photo-detector to remove the interference of the excitation light with fluorescence. These techniques allow the LED fluorimeter to accurately measure the fluorescence lifetime of fluorescein down to concentration of 0.5 ?M. In addition, all filters required in traditional instruments are eliminated for the non-attenuated excitation/emission light power. These achievements make the reported device attractive to biochemical laboratories seeking for highly portable lifetime detection devices for developing sensors based on fluorescence lifetime changes. The device was initially validated by measuring the lifetimes of three commercial fluorophores and comparing them with reported lifetime data. It was subsequently used to characterize a ZnSe quantum dot based DNA sensor.

  14. An experimental study of spatial effects on mean neutron lifetime measurement 

    E-Print Network [OSTI]

    Hooke, William Bruce

    1966-01-01

    and Reactor Stability Analysis", USAEC Report ANL-6205, Argonne National Laboratory, May, 1960 Qazi, M. N. , "An Oscillator Measurement of the Prompt Neutron Lifetime in the Pennsylvania State University Reactor, ' Unpublished Masters Thesis, Pennsylvania... OF SCIENCE May, 1966 Major Subject Nuclear Engineering AN EXPERIMENTAL STUDY OF SPATIAL EFFECTS ON MEAN NEUTRON LIFETIME MEASUREMENT A Thesis By William Bruce Hooks Approved as to style and content by: airman o ommx tee ea o epar men e er e er e er...

  15. Ratio of D/sup 0/ and D/sup +/ lifetimes from their semileptonic decays

    SciTech Connect (OSTI)

    Donaldson, G.J.

    1980-06-01

    The conventional expectation for the decays of D mesons assumes that the charm quark decays in the presence of light, spectator quarks and thus the lifetimes of both charged and uncharged states are equal. In this article, evidence is presented from DELCO (at SPEAR) that the D lifetimes are quite different for neutral and charged mesons, and the results which have also become available from other experiments are reviewed.

  16. New evaluation of neutron lifetime from UCN storage experiments and beam experiments

    E-Print Network [OSTI]

    A. P. Serebrov; A. K. Fomin

    2011-04-21

    The analysis of experiments on measuring neutron lifetime has been made. The latest most accurate result of measuring neutron lifetime [Phys. Lett. B 605, 72 (2005)] 878.5 \\pm 0.8 s differs from the world average value [Phys. Lett. B 667, 1 (2008)] 885.7 \\pm 0.8 s by 6.5 standard deviations. In view of this both the analysis and the Monte Carlo simulation of experiments [Phys. Lett. B 483, 15 (2000)] and [Phys. Rev. Lett. 63, 593 (1989)] have been performed. Systematic errors about -6 s have been found in both experiments. The table of results of neutron lifetime measurements is given after corrections and additions have been made. A new world average value of neutron lifetime makes up 880.0 \\pm 0.9 s. Here is also presented a separate analysis of experiments on measuring neutron lifetime with UCN and experiments on the beams. The average neutron lifetime for experiments with UCN is equal to 879.3(0.6) s, while for experiments on the beams it is equal to 889.1(2.9) s. The present difference of average values for both groups is (3.3 sigma) and needs consideration. The contribution of beam experiments into the world average value is not high, therefore it does not influence the above analysis. However, it is an independent problem to be solved. It seems desirable that the precision of beam experiments should be enhanced.

  17. Power Blackout Risks Risk Management Options

    E-Print Network [OSTI]

    Schrijver, Karel

    Power Blackout Risks Risk Management Options Emerging Risk Initiative ­ Position Paper November 2011 #12;2 Content 1. Summary 3 2. Power blackouts challenge society and economy 4 3. Blackout risks on the increase 5 3.1. How power market trends influence blackout risks 5 3.1.1. Liberalisation and privatisation

  18. Josephine Ford Cancer Center Cancer Research Programs

    E-Print Network [OSTI]

    Finley Jr., Russell L.

    Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

  19. Ecological Risk Assessments

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ecological Risk Assessments Ecological Risk Assessments Ecological risk assessment is the appraisal of potential adverse effects of exposure to contaminants on plants and animals....

  20. Hurricane wind fields needed to assess risk to offshore wind farms

    E-Print Network [OSTI]

    Jaramillo, Paulina

    LETTER Hurricane wind fields needed to assess risk to offshore wind farms In their paper in PNAS losses attributable to hurricane activity at four hypothetical offshore wind farm sites. We found one a 20-y typical wind farm lifetime. They combined a county annual landfall frequency probability density

  1. What is the probability that radiation caused a particular cancer

    SciTech Connect (OSTI)

    Voelz, G.L.

    1983-01-01

    Courts, lawyers, health physicists, physicians, and others are searching for a credible answer to the question posed in the title of this paper. The cases in which the question arises frequently stem from an individual that has cancer and they, or their next-of-kin, are convinced that a past radiation exposure - usually small - is responsible for causing it. An arithmetic expression of this problem is simple: the probability of causation by the radiation dose in question is equal to the risk of cancer from the radiation dose divided by the risk of cancer from all causes. The application of risk factors to this equation is not so simple. It must involve careful evaluation of the reliability of and variations in risk coefficients for development of cancer due to radiation exposure, other carcinogenic agents, and natural causes for the particular individual. Examination of our knowledge of these various factors indicates that a large range in the answers can result due to the variability and imprecision of the data. Nevertheless, the attempts to calculate and the probability that radiation caused the cancer is extremely useful to provide a gross perspective on the probability of causation. It will likely rule in or out a significant number of cases despite the limitations in our understandings of the etiology of cancer and the risks from various factors. For the remaining cases, a thoughtful and educated judgment based on selected data and circumstances of the case will also be needed before the expert can develop and support his opinion.

  2. Radiation risk to low fluences of particles may be greater than we thought

    E-Print Network [OSTI]

    on Radiation Protection and Measurements (NCRP) have recommended that estimates of cancer risk for low doseRadiation risk to low fluences of particles may be greater than we thought Hongning Zhou*, Masao to reconsider the validity of the linear extrapolation in making risk estimates for low dose, high linear

  3. Enterprise Risk Management Program

    E-Print Network [OSTI]

    Hayden, Nancy J.

    Enterprise Risk Management Program Guide to Risk Assessment & Response August 16, 2012 #12; i ...........26 List of Figures Figure 1: The Risk Management Process.......................................................................................................12 #12; 1 Overview The risk management process--of identifying, analyzing, evaluating

  4. Site Risks:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect Photovoltaics -7541 UnlimitedShiftwater vaporRisks: ď‚· Radiation - alpha,

  5. Impact of Minority Carrier Lifetime on the Performance of Strained Ge Light Sources

    E-Print Network [OSTI]

    Sukhdeo, David S; Birendra,; Dutt,; Nam, Donguk

    2015-01-01

    We theoretically investigate the impact of the defect-limited carrier lifetime on the performance of germanium (Ge) light sources, specifically LEDs and lasers. For Ge LEDs, we show that improving the material quality can offer even greater enhancements than techniques such as tensile strain, the leading approach for enhancing Ge light emission. Even for Ge that is so heavily strained that it becomes a direct bandgap semiconductor, the ~1 ns defect-limited carrier lifetime of typical epitaxial Ge limits the LED internal quantum efficiency to less than 10%. In contrast, if the epitaxial Ge carrier lifetime can be increased to its bulk value, internal quantum efficiencies exceeding 90% become possible. For Ge lasers, we show that the defect-limited lifetime becomes increasing important as tensile strain is introduced, and that this defect-limited lifetime must be improved if the full benefits of strain are to be realized. We conversely show that improving the material quality supersedes much of the utility of n...

  6. Alignments Of Black Holes With Their Warped Accretion Disks And Episodic Lifetimes Of Active Galactic Nuclei

    E-Print Network [OSTI]

    Yan-Rong Li; Jian-Min Wang; Cheng Cheng; Jie Qiu

    2015-03-02

    Warped accretion disks have attracted intensive attention because of their critical role on shaping the spin of supermassive massive black holes (SMBHs) through the Bardeen-Petterson effect, a general relativistic effect that leads to final alignments or anti-alignments between black holes and warped accretion disks. We study such alignment processes by explicitly taking into account the finite sizes of accretion disks and the episodic lifetimes of AGNs that delineate the duration of gas fueling onto accretion disks. We employ an approximate global model to simulate the evolution of accretion disks, allowing to determine the gravitomagnetic torque that drives the alignments in a quite simple way. We then track down the evolutionary paths for mass and spin of black holes both in a single activity episode and over a series of episodes. Given with randomly and isotropically oriented gas fueling over episodes, we calculate the spin evolution with different episodic lifetimes and find that it is quite sensitive to the lifetimes. We therefore propose that spin distribution of SMBHs can place constraints on the episodic lifetimes of AGNs and vice versa. Applications of our results on the observed spin distributions of SMBHs and the observed episodic lifetimes of AGNs are discussed, although both the measurements at present are yet ambiguous to draw a firm conclusion. Our prescription can be easily incorporated into semi-analytic models for black hole growth and spin evolution.

  7. Robust Maximum Lifetime Routing and Energy Allocation in Wireless Sensor Networks

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Paschalidis, Ioannis Ch.; Wu, Ruomin

    2012-01-01

    We consider the maximum lifetime routing problem in wireless sensor networks in two settings: (a) when nodes’ initial energy is given and (b) when it is subject to optimization. The optimal solution and objective value provide optimal flows and the corresponding predicted lifetime, respectively. We stipulate that there is uncertainty in various network parameters (available energy and energy depletion rates). In setting (a) we show that for specific, yet typical, network topologies, the actual network lifetime will reach the predicted value with a probability that converges to zero as the number of nodes grows large. In setting (b) the samemore »result holds for all topologies. We develop a series of robust problem formulations, ranging from pessimistic to optimistic. A set of parameters enable the tuning of the conservatism of the formulation to obtain network flows with a desirably high probability that the corresponding lifetime prediction is achieved. We establish a number of properties for the robust network flows and energy allocations and provide numerical results to highlight the tradeoff between predicted lifetime and the probability achieved. Further, we analyze an interesting limiting regime of massively deployed sensor networks and essentially solve a continuous version of the problem.« less

  8. Risk Management, Mar 2012 Risk Management

    E-Print Network [OSTI]

    Risk Management, Mar 2012 Risk Management Conditions of Volunteer Service (Please send completed form to the Office of Risk Management) riskmanagement@uoregon.edu Fax: 541-346-7008 As a volunteer Tort Claims Act, ORS 30.260-300, and Oregon Department of Administrative Services Risk Management

  9. Dependence of nuclear spin singlet lifetimes on RF spin-locking power

    E-Print Network [OSTI]

    Stephen J. DeVience; Ronald L. Walsworth; Matthew S. Rosen

    2012-01-06

    We measure the lifetime of long-lived nuclear spin singlet states as a function of the strength of the RF spin-locking field and present a simple theoretical model that agrees well with our measurements, including the low-RF-power regime. We also measure the lifetime of a long-lived coherence between singlet and triplet states that does not require a spin-locking field for preservation. Our results indicate that for many molecules, singlet states can be created using weak RF spin-locking fields: more than two orders of magnitude lower RF power than in previous studies. Our findings suggest that in many biomolecules, singlets and related states with enhanced lifetimes might be achievable in vivo with safe levels of RF power.

  10. Dependence of nuclear spin singlet lifetimes on RF spin-locking power

    E-Print Network [OSTI]

    DeVience, Stephen J; Rosen, Matthew S

    2012-01-01

    We measure the lifetime of long-lived nuclear spin singlet states as a function of the strength of the RF spin-locking field and present a simple theoretical model that agrees well with our measurements, including the low-RF-power regime. We also measure the lifetime of a long-lived coherence between singlet and triplet states that does not require a spin-locking field for preservation. Our results indicate that for many molecules, singlet states can be created using weak RF spin-locking fields: more than two orders of magnitude lower RF power than in previous studies. Our findings suggest that in many biomolecules, singlets and related states with enhanced lifetimes might be achievable in vivo with safe levels of RF power.

  11. Lifetime measurement of excited low-spin states via the $(p,p^{\\prime}\\gamma$) reaction

    E-Print Network [OSTI]

    Hennig, A; Mineva, M N; Petkov, P; Pickstone, S G; Spieker, M; Zilges, A

    2015-01-01

    In this article a method for lifetime measurements in the sub-picosecond regime via the Doppler-shift attenuation method (DSAM) following the inelastic proton scattering reaction is presented. In a pioneering experiment we extracted the lifetimes of 30 excited low-spin states of $^{96}$Ru, taking advantage of the coincident detection of scattered protons and de-exciting $\\gamma$-rays as well as the large number of particle and $\\gamma$-ray detectors provided by the SONIC@HORUS setup at the University of Cologne. The large amount of new experimental data shows that this technique is suited for the measurement of lifetimes of excited low-spin states, especially for isotopes with a low isotopic abundance, where $(n,n^{\\prime}\\gamma$) or - in case of investigating dipole excitations - ($\\gamma,\\gamma^{\\prime}$) experiments are not feasible due to the lack of sufficient isotopically enriched target material.

  12. Lifetime measurement of excited low-spin states via the $(p,p^{\\prime}?$) reaction

    E-Print Network [OSTI]

    A. Hennig; V. Derya; M. N. Mineva; P. Petkov; S. G. Pickstone; M. Spieker; A. Zilges

    2015-06-19

    In this article a method for lifetime measurements in the sub-picosecond regime via the Doppler-shift attenuation method (DSAM) following the inelastic proton scattering reaction is presented. In a pioneering experiment we extracted the lifetimes of 30 excited low-spin states of $^{96}$Ru, taking advantage of the coincident detection of scattered protons and de-exciting $\\gamma$-rays as well as the large number of particle and $\\gamma$-ray detectors provided by the SONIC@HORUS setup at the University of Cologne. The large amount of new experimental data shows that this technique is suited for the measurement of lifetimes of excited low-spin states, especially for isotopes with a low isotopic abundance, where $(n,n^{\\prime}\\gamma$) or - in case of investigating dipole excitations - ($\\gamma,\\gamma^{\\prime}$) experiments are not feasible due to the lack of sufficient isotopically enriched target material.

  13. Comprehensive Cancer Center Nutrition

    E-Print Network [OSTI]

    Anderson, Paul R.

    Comprehensive Cancer Center Nutrition Bldg.Pedestrian Link from Ardmore Tower to Comprehensive Cancer Center on Ground Floor Emergency Room Parking Ardmore Cafeteria Ardmore Tower North Tower Janeway

  14. Nuclear matrix elements from direct lifetime or cross-section measurements

    SciTech Connect (OSTI)

    Werner, V.; Cooper, N.; Hinton, M.; Ilie, G.; Radeck, D.

    2012-11-20

    The method of simultaneous lifetime and g factor measurements using a plunger device and the RDDS and TDRIV techniques is introduced. Results on lifetimes and hyperfine-interaction parameters for 2{sup +}{sub 1} states in {sup 104-108}Pd, {sup 96,98,104}Ru, and {sup 92,94}Zr, using a plunger device. Another method to obtain electromagnetic matrix elements is direct cross section measurements using NRF. The method is outlined, and some recent results on {sup 76}Se are shown.

  15. Note on an integral expression for the average lifetime of the bound state in 2D

    E-Print Network [OSTI]

    Thorsten Prustel; Martin Meier-Schellersheim

    2012-10-04

    Recently, an exact Green's function of the diffusion equation for a pair of spherical interacting particles in two dimensions subject to a backreaction boundary condition was used to derive an exact expression for the average lifetime of the bound state. Here, we show that the corresponding divergent integral may be considered as the formal limit of a Stieltjes transform. Upon analytically calculating the Stieltjes transform one can obtain an exact expression for the finite part of the divergent integral and hence for the average lifetime.

  16. Genetic variants on 15q25.1, smoking and lung cancer: an assessment of mediation and interaction

    E-Print Network [OSTI]

    Lin, Xihong

    1 Genetic variants on 15q25.1, smoking and lung cancer: an assessment of mediation and interaction-wide association studies have identified variants on chromosome 15q25.1 that increase the risk of both lung cancer as to whether the association with lung cancer is direct or mediated by pathways related to smoking behavior

  17. Development of a Standardized Method for Contouring the Lumbosacral Plexus: A Preliminary Dosimetric Analysis of this Organ at Risk Among 15 Patients Treated With Intensity-Modulated Radiotherapy for Lower Gastrointestinal Cancers and the Incidence of Radiation-Induced Lumbosacral Plexopathy

    SciTech Connect (OSTI)

    Yi, Sun K., E-mail: sun.yi@ucdmc.ucdavis.edu [Department of Radiation Oncology, University of California, Davis Cancer Center, Sacramento, CA (United States); Mak, Walter [Department of Radiology, University of California, Davis Medical Center, Sacramento, CA (United States)] [Department of Radiology, University of California, Davis Medical Center, Sacramento, CA (United States); Yang, Claus C.; Liu Tianxiao [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS (United States)] [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS (United States); Cui Jing; Chen, Allen M.; Purdy, James A.; Monjazeb, Arta M. [Department of Radiation Oncology, University of California, Davis Cancer Center, Sacramento, CA (United States)] [Department of Radiation Oncology, University of California, Davis Cancer Center, Sacramento, CA (United States); Do, Ly [Cancer Care Institute, San Jose, CA (United States)] [Cancer Care Institute, San Jose, CA (United States)

    2012-10-01

    Purpose: To generate a reproducible step-wise guideline for the delineation of the lumbosacral plexus (LSP) on axial computed tomography (CT) planning images and to provide a preliminary dosimetric analysis on 15 representative patients with rectal or anal cancers treated with an intensity-modulated radiotherapy (IMRT) technique. Methods and Materials: A standardized method for contouring the LSP on axial CT images was devised. The LSP was referenced to identifiable anatomic structures from the L4-5 interspace to the level of the sciatic nerve. It was then contoured retrospectively on 15 patients treated with IMRT for rectal or anal cancer. No dose limitations were placed on this organ at risk during initial treatment planning. Dosimetric parameters were evaluated. The incidence of radiation-induced lumbosacral plexopathy (RILSP) was calculated. Results: Total prescribed dose to 95% of the planned target volume ranged from 50.4 to 59.4 Gy (median 54 Gy). The mean ({+-}standard deviation [SD]) LSP volume for the 15 patients was 100 {+-} 22 cm{sup 3} (range, 71-138 cm{sup 3}). The mean maximal dose to the LSP was 52.6 {+-} 3.9 Gy (range, 44.5-58.6 Gy). The mean irradiated volumes of the LSP were V40Gy = 58% {+-} 19%, V50Gy = 22% {+-} 23%, and V55Gy = 0.5% {+-} 0.9%. One patient (7%) was found to have developed RILSP at 13 months after treatment. Conclusions: The true incidence of RILSP in the literature is likely underreported and is not a toxicity commonly assessed by radiation oncologists. In our analysis the LSP commonly received doses approaching the prescribed target dose, and 1 patient developed RILSP. Identification of the LSP during IMRT planning may reduce RILSP. We have provided a reproducible method for delineation of the LSP on CT images and a preliminary dosimetric analysis for potential future dose constraints.

  18. Risk Management Policy 1 Risk Management Policy (December, 2014)

    E-Print Network [OSTI]

    Wapstra, Erik

    Risk Management Policy 1 Risk Management Policy (December, 2014) Risk Management Policy Responsible Governance Level Principle No. 2 - Risk Management Responsible Organisational Unit Audit & Risk CONTENTS 1 ........................................................................................................2 3.1 Effective Risk Management

  19. 18 Abstracts, 10th Nottingham International Breast Cancer Conference, 18-20 September 2007 O-56 Quality assurance issues in breast cancer

    E-Print Network [OSTI]

    Aickelin, Uwe

    to the outside and vice versa. This is called the exchange time. The exchange time is related to the permeability for screening women at high risk of developing breast cancer due to a genetic disposition. This results led

  20. Risk Management Strategy Introduction

    E-Print Network [OSTI]

    Edinburgh, University of

    Risk Management Strategy Introduction 1. The risk of adverse consequences is inherent in all activity. Dynamic enterprise will inevitably create new risks. Risk management is about ensuring that all significant relevant risks are understood and prioritised as part of normal management

  1. Lung Cancer James Nguyen

    E-Print Network [OSTI]

    Brutlag, Doug

    Lung Cancer James Nguyen Biochemistry 118Q Doug Brutlag A Case Study of Genetics and Environment #12;Lung Cancer · Leading cause of cancer for men and women in United States · Every year, about 164,000 new cases are diagnosed in the US, with an estimated 157,000 deaths. · Leading cause of cancer death

  2. The National Cancer Institute,

    E-Print Network [OSTI]

    The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

  3. LIFETIME OF THE EXCITED STATE IN VIVO I. CHLOROPHYLL a IN ALGAE, AT ROOM

    E-Print Network [OSTI]

    Govindjee

    LIFETIME OF THE EXCITED STATE IN VIVO I. CHLOROPHYLL a IN ALGAE, AT ROOM AND AT LIQUID NITROGEN decay of chloro- phyll (Chl) a in the green alga Chlorella pyrenoidosa, the red alga Porphyridium cruentum, and the blue-green alga Anacystis nidulans was measured by the phase- shift method under

  4. History-based, Online, Battery Lifetime Prediction for Embedded and Mobile Devices

    E-Print Network [OSTI]

    Krintz, Chandra

    History-based, Online, Battery Lifetime Prediction for Embedded and Mobile Devices Ye Wen Rich approach on a widely used mobile device (HP iPAQ) running Linux, and compare it to two similar battery pre- diction technologies: ACPI and Smart Battery. We em- ploy twenty-two constant and variable workloads

  5. Lifetime-Aware Hierarchical Wireless Sensor Network Architecture with Mobile Overlays

    E-Print Network [OSTI]

    Pedram, Massoud

    ,morteza,pedram}@usc.edu ABSTRACT-- Recent technological advances have led to the emergence of small battery-powered sensors battery replacement in a large network is not a feasible solution, we consider mobile relays. Mobility1 Lifetime-Aware Hierarchical Wireless Sensor Network Architecture with Mobile Overlays Maryam

  6. Genetic variation in nuclear and mitochondrial markers supports a large sex difference in lifetime reproductive

    E-Print Network [OSTI]

    and Engineering Research Council of Canada. YIV was supported by a start-up grant to TP from the University in skews of vertebrate lifetime reproductive success are difficult to measure directly. Evolutionary; Kokko et al. 1998, 1999). Variance in LRS may be smaller than expected because mating skews at leks

  7. DEVELOPMENT AND OPTIMIZATION OF BACK SURFACE ACRYLIC SOLAR MIRRORS TO ASSURE 25 YEAR LIFETIME PERFORMANCE

    E-Print Network [OSTI]

    Rollins, Andrew M.

    DEVELOPMENT AND OPTIMIZATION OF BACK SURFACE ACRYLIC SOLAR MIRRORS TO ASSURE 25 YEAR LIFETIME at NREL was extremely valuable in completing this work. Funding for this project was obtained from Ohio 2. Literature Review 10 Solar Mirrors 10 Technology Development 15 Substrate PMMA Acrylic Weathering

  8. Sensor Network Lifetime Maximization Via Sensor Energy Balancing: Construction and Optimal Scheduling of Sensor Trees

    E-Print Network [OSTI]

    Johansson, Karl Henrik

    in such a way that the total energy usage of the active sensor nodes in the tree is minimized. However whenSensor Network Lifetime Maximization Via Sensor Energy Balancing: Construction and Optimal, node energy, etc), the collected data are transmitted to their final destination, usually a fusion

  9. Development of a high average current polarized electron source with long cathode operational lifetime

    SciTech Connect (OSTI)

    C. K. Sinclair; P. A. Adderley; B. M. Dunham; J. C. Hansknecht; P. Hartmann; M. Poelker; J. S. Price; P. M. Rutt; W. J. Schneider; M. Steigerwald

    2007-02-01

    Substantially more than half of the electromagnetic nuclear physics experiments conducted at the Continuous Electron Beam Accelerator Facility of the Thomas Jefferson National Accelerator Facility (Jefferson Laboratory) require highly polarized electron beams, often at high average current. Spin-polarized electrons are produced by photoemission from various GaAs-based semiconductor photocathodes, using circularly polarized laser light with photon energy slightly larger than the semiconductor band gap. The photocathodes are prepared by activation of the clean semiconductor surface to negative electron affinity using cesium and oxidation. Historically, in many laboratories worldwide, these photocathodes have had short operational lifetimes at high average current, and have often deteriorated fairly quickly in ultrahigh vacuum even without electron beam delivery. At Jefferson Lab, we have developed a polarized electron source in which the photocathodes degrade exceptionally slowly without electron emission, and in which ion back bombardment is the predominant mechanism limiting the operational lifetime of the cathodes during electron emission. We have reproducibly obtained cathode 1/e dark lifetimes over two years, and 1/e charge density and charge lifetimes during electron beam delivery of over 2?105???C/cm2 and 200 C, respectively. This source is able to support uninterrupted high average current polarized beam delivery to three experimental halls simultaneously for many months at a time. Many of the techniques we report here are directly applicable to the development of GaAs photoemission electron guns to deliver high average current, high brightness unpolarized beams.

  10. Z .Applied Surface Science 149 1999 97102 Unfolding positron lifetime spectra with neural networks

    E-Print Network [OSTI]

    Pázsit, Imre

    Z .Applied Surface Science 149 1999 97­102 Unfolding positron lifetime spectra with neural networks is based on the use of artificial neural networks ANNs . By using data from simulated positron spectra: Artificial neural networks ANNs ; Amplitudes; Simulation model 1. Introduction Determination of mean

  11. Lifetime broadening in the gas phase ~BB2 electronic spectrum of C8H

    E-Print Network [OSTI]

    Maier, John Paul

    . It is con- cluded that the rotational lines are broadened by rapid radiationless transitions fromLifetime broadening in the gas phase ~BB2 P ~XX2 P electronic spectrum of C8H Petre Birza, Dmitriy transition of linear C8H was recorded in a planar supersonic ex- pansion by a cw cavity ring

  12. Lifetime Assessment for Thermal Barrier Coatings: Tests for Measuring Mixed Mode Delamination Toughness

    E-Print Network [OSTI]

    Hutchinson, John W.

    Lifetime Assessment for Thermal Barrier Coatings: Tests for Measuring Mixed Mode Delamination Mechanisms leading to degradation of the adherence of thermal barrier coatings (TBC) used in aircraft of coatings have not emerged based on predictions of the degradation processes due to their complexity

  13. Testing the effect of surface coatings on alkali atom polarization lifetimes S. J. Seltzer,1

    E-Print Network [OSTI]

    Romalis, Mike

    Testing the effect of surface coatings on alkali atom polarization lifetimes S. J. Seltzer,1 D. M The evaluation of different surface coatings used in alkali metal atomic magnetometers is necessary in the region between substrates with different coatings was developed to determine the effectiveness

  14. Electron generation of leptons and hadrons with reciprocal -quantized lifetimes and masses

    E-Print Network [OSTI]

    1 Electron generation of leptons and hadrons with reciprocal -quantized lifetimes and masses generation occurs via an initial "-leap" from an electron pair to a "platform state" M, and then subsequent in the generation of hadron masses. In fact, the role of the electron in generating lepton masses has never been

  15. Centralized Routing Protocol for Wireless Sensor Networks with Ultra Low Duty Cycle to Achieve Maximum Lifetime

    E-Print Network [OSTI]

    Bahk, Saewoong

    Centralized Routing Protocol for Wireless Sensor Networks with Ultra Low Duty Cycle to Achieve performance because most of them are designed without considering a ultra low duty cycled environment to improve a network lifetime and a routing maintenance cost. We explain the issues of a ultra low duty

  16. Film drainage and the lifetime of bubbles C. T. Nguyen, H. M. Gonnermann, and Y. Chen

    E-Print Network [OSTI]

    Gonnermann, Helge

    Film drainage and the lifetime of bubbles C. T. Nguyen, H. M. Gonnermann, and Y. Chen Department film thinning and bubble coalescence as a consequence of liquid expulsion by gravitational.25 film drainage is due to capillary forces, whereas at Bo > 0.25 gravitational forces result in film

  17. Isolating signatures of major cloud-cloud collisions II: The lifetimes of broad bridge features

    E-Print Network [OSTI]

    Haworth, T J; Tasker, E J; Fukui, Y; Torii, K; Dale, J E; Takahira, K; Habe, A

    2015-01-01

    We investigate the longevity of broad bridge features in position-velocity diagrams that appear as a result of cloud-cloud collisions. Broad bridges will have a finite lifetime due to the action of feedback, conversion of gas into stars and the timescale of the collision. We make a series of analytic arguments with which to estimate these lifetimes. Our simple analytic arguments suggest that for collisions between clouds larger than R~10 pc the lifetime of the broad bridge is more likely to be determined by the lifetime of the collision rather than the radiative or wind feedback disruption timescale. However for smaller clouds feedback becomes much more effective. This is because the radiative feedback timescale scales with the ionising flux Nly as R^{7/4}Nly^{-1/4} so a reduction in cloud size requires a relatively large decrease in ionising photons to maintain a given timescale. We find that our analytic arguments are consistent with new synthetic observations of numerical simulations of cloud-cloud collisi...

  18. Lifetime Behavior and its Impact on Web Caching Xiangping Chen and Prasant Mohapatra

    E-Print Network [OSTI]

    Mohapatra, Prasant

    Lifetime Behavior and its Impact on Web Caching Xiangping Chen and Prasant Mohapatra Department@iastate.edu Abstract The exponential growth of the World Wide Web has made it the most popular information on the web to al­ leviate the web server load, conserve the network band­ width, and reduce the retrieval

  19. Network lifetime maximization for time-sensitive data gathering in wireless sensor networks

    E-Print Network [OSTI]

    Liang, Weifa

    or human inaccessible environments such as battlefields or nuclear polluted re- gions. Therefore, energy Keywords: Wireless sensor networks Network lifetime prolongation Energy optimization Load-balanced spanning tree Network flow Algorithm design a b s t r a c t Energy-constrained sensor networks have been widely

  20. Classes of multivariate lifetimes distributions based on the multivariate excess wealth function

    E-Print Network [OSTI]

    Ceragioli, Francesca

    Classes of multivariate lifetimes distributions based on the multivariate excess wealth function of their quantile functions and excess wealth func- tions. Here we consider the multivariate versions of these characterizations, defining new multivariate aging classes based on properties of the multivariate u

  1. J-RoC: a Joint Routing and Charging Scheme to Prolong Sensor Network Lifetime

    E-Print Network [OSTI]

    Qiao, Daji

    -lasting and fundamental problem. To address this issue, harvesting the ambient energy such as solar [1], wind [2. Zhang et al. [7] apply this technique to replenish battery energy in med- ical sensors and implantableJ-RoC: a Joint Routing and Charging Scheme to Prolong Sensor Network Lifetime Zi Li, Yang Peng

  2. Maximizing Network Lifetime Via 3G Gateway Assignment in Dual-Radio Sensor Networks

    E-Print Network [OSTI]

    Liang, Weifa

    - ments, such as temperature, humidity, wind, solar radiation, etc. [3]. Sensor nodes are typically as well as in the idling cost [5]. If all sensors are gateways, they will run out of energy within a shortMaximizing Network Lifetime Via 3G Gateway Assignment in Dual-Radio Sensor Networks Xu Xu, Weifa

  3. Accurate economic analysis of photovoltaic (PV) systems performance over the system lifetime requires knowledge

    E-Print Network [OSTI]

    Oregon, University of

    ABSTRACT Accurate economic analysis of photovoltaic (PV) systems performance over the system placed on the performance of the photovoltaic (PV) system over the lifetime of the system. Many. The economic evaluation is dependent on system production, MEASURING DEGRADATION OF PHOTOVOLTAIC MODULE

  4. Aalborg Universitet Novel Battery Thermal Management System for Greater Lifetime Ratifying Current

    E-Print Network [OSTI]

    Berning, Torsten

    , telecommunications installations, large industrial and commercial installations, large uninterruptible power supply and drawback for any attempt to scale-up battery cells to the larger sizes as required for high power acceptance; o power and energy capability; o reliability; o lifetime and life cycle cost. Thereof

  5. Measured lifetimes of metastable levels of Mn X, Mn XI, Mn XII, and Mn XIII ions 

    E-Print Network [OSTI]

    Moehs, D. P.; Church, David A.

    1999-01-01

    An ion storage technique, based on the capture of metastable multiply charged ions from an external ion source into a Kingdon ion trap, has been used to measure the lifetimes of eight metastable levels of Mn ions with 3s(2)3p(k) configurations, k...

  6. SENSOR PLACEMENT FOR MAXIMIZING LIFETIME PER UNIT COST IN WIRELESS SENSOR NETWORKS

    E-Print Network [OSTI]

    Chuah, Chen-Nee

    in a wireless sensor network (WSN). Analyzing the lifetime per unit cost of a linear WSN, we find that deploying commercial and military applications. A WSN consists of a large number of low-cost, low-power, energy the sen- sor placement and the transmission structure in a one- dimensional data-gathering WSN

  7. Temperature dependent vibrational lifetimes in supercritical fluids near the critical point

    E-Print Network [OSTI]

    Fayer, Michael D.

    also initially increases with increasing temperature. However, in supercritical CO2 at the critical, fluoroform, and CO2 solvents are presented and analyzed. The measurements are made at constant densityTemperature dependent vibrational lifetimes in supercritical fluids near the critical point D. J

  8. Robust Lifetime Measurement in Large-Scale P2P Systems with Non-Stationary Arrivals

    E-Print Network [OSTI]

    Yao, Zhongmei

    @nec-labs.com Abstract--Characterizing user churn has become an important topic in studying P2P networks, both impossible. We overcome this problem using two contributions: a novel non-stationary ON/OFF churn model and the corresponding analysis of lifetime sampling. We focus on these issues next. A. Non-Stationary User Churn Recall

  9. Alternative Size and Lifetime Measurements for High-Energy Heavy-Ion Collisions

    E-Print Network [OSTI]

    Scott Pratt; Silvio Petriconi

    2003-06-16

    Two-Particle correlations based on the interference of identical particles has provided the chief means for determining the shape and lifetime of sources in relativistic heavy ion collisions. Here, Strong and Coulomb induced correlations are shown to provide equivalent information.

  10. NEUTRON DAMAGE IN REACTOR PRESSURE-VESSEL STEEL EXAMINED WITH POSITRON ANNIHILATION LIFETIME SPECTROSCOPY

    E-Print Network [OSTI]

    Motta, Arthur T.

    annealing the samples at 280' C. INTRODUCTION Reactor pressure-vessel steel embrittlement is one ofthe mostNEUTRON DAMAGE IN REACTOR PRESSURE-VESSEL STEEL EXAMINED WITH POSITRON ANNIHILATION LIFETIME spectroscopy to study the development of damage and annealing behavior ofneutron-irradiated reactor pressure

  11. Adaptive Data Collection Strategies for Lifetime-Constrained Wireless Sensor Networks

    E-Print Network [OSTI]

    Tang, Xueyan

    significantly improve the accuracy of data collected by the base station. Index Terms--data collection, energy to the energy constraint [7]. However, this approach is not effective. Consider, for example, a series of solar1 Adaptive Data Collection Strategies for Lifetime-Constrained Wireless Sensor Networks Xueyan Tang

  12. Excitation energies, polarizabilities, multipole transition rates, and lifetimes of ions along the francium isoelectronic sequence

    E-Print Network [OSTI]

    Safronova, Marianna

    Excitation energies, polarizabilities, multipole transition rates, and lifetimes of ions along rates and oscillator strengths for a limited number of transitions using the energies given by Blaise, energies of the 7s, 7p, 6d, and 5f states of Fr-like ions with nuclear charges Z =87­100 are calculated

  13. A LIFETIME PREDICTION MODEL FOR SINGLE CRYSTAL SUPERALLOYS SUBJECTED TO THERMOMECHANICAL

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    materials tensile, creep and LCF test data at different temperatures. Some parameters, independentA LIFETIME PREDICTION MODEL FOR SINGLE CRYSTAL SUPERALLOYS SUBJECTED TO THERMOMECHANICAL CREEP for Single Crystal Superalloys operated at high temperatures and subjected to creep, fatigue and oxidation

  14. Experimental determination of neutron lifetimes through macroscopic neutron noise in the IPEN/MB-01 reactor

    SciTech Connect (OSTI)

    Gonnelli, Eduardo; Diniz, Ricardo [Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP Travessa R-400, 05508-900, Cidade Universitaria, Sao Paulo (Brazil)

    2013-05-06

    The neutron lifetimes of the core, reflector, and global were experimentally obtained through macroscopic neutron noise in the IPEN/MB-01 reactor for five levels of subcriticality. The theoretical Auto Power Spectral Densities were derived by point kinetic equations taking the reflector effect into account, and one of the approaches consider an additional group of delayed neutrons.

  15. Fluorescence Lifetime of Emitters with Broad Homogeneous Linewidths Modified in Opal Photonic Crystals

    E-Print Network [OSTI]

    Vos, Willem L.

    Fluorescence Lifetime of Emitters with Broad Homogeneous Linewidths Modified in Opal Photonic, 2008 We have investigated the dynamics of spontaneous emission from dye molecules embedded in opal optical frequency and crystal lattice parameter of the polystyrene opals. Due to the broad homogeneous

  16. Extending the Lifetime of Portable Video Communication Devices Using Power-Rate-Distortion Optimization

    E-Print Network [OSTI]

    He, Zhihai "Henry"

    -Rate-Distortion Optimization Zhihai He, Wenye Cheng, and Xi Chen Ł Department of Electrical and Computer Engineering University framework to save the data processing energy and extend the operational lifetime of portable video communication devices. Video compression is computationally intensive and energy-consuming. However, portable

  17. Application and modeling of frequency-domain lifetime spectroscopy for microsphere-based optical glucose sensors 

    E-Print Network [OSTI]

    Liang, Feng

    2009-05-15

    changes in the presence of glucose at concentrations ranging from 0 to 224 mg/dL. The second set of experiments proved the feasibility of performing analyte sensing with FD lifetime spectroscopy using microsphere-based sensors in multiple scattering...

  18. STUDY OF CLOUD LIFETIME EFFECTS USING THE SGP HETEROGENEOUS DISTRIBUTED RADAR NETWORK: PRELIMINARY CONSIDERATIONS

    E-Print Network [OSTI]

    STUDY OF CLOUD LIFETIME EFFECTS USING THE SGP HETEROGENEOUS DISTRIBUTED RADAR NETWORK: PRELIMINARY-dimensional morphology and life cycle of clouds. Detailing key cloud processes as they transit from the formation stage to precipitation onset and cloud dissipation is critical towards establishing uncertainties in climate models

  19. Efficient Battery Management for Sensor Lifetime Malka N. Halgamuge, Student Member, IEEE

    E-Print Network [OSTI]

    Halgamuge, Malka N.

    Efficient Battery Management for Sensor Lifetime Malka N. Halgamuge, Student Member, IEEE It is challenging to design a sensor network if sensors are battery powered. Efficient scheduling and budgeting battery power in sensor networks has become a critical issue in net- work design. We investigate how

  20. Exploiting Overhearing: Flow-Aware Routing for Improved Lifetime in Ad Hoc Networks

    E-Print Network [OSTI]

    Mans, Bernard

    neighboring flows and adapt their local routing dynamically. By combining this awareness with battery- aware flow and neighborhood is then presented in Section II-D. By combining the flow awareness with batteryExploiting Overhearing: Flow-Aware Routing for Improved Lifetime in Ad Hoc Networks Nirisha

  1. BRCA1-linked marker in postmenopausal breast cancer families

    SciTech Connect (OSTI)

    Folsom, A.R.; Chen, P.L.; Sellers, T.A.

    1994-09-01

    A majority of breast and ovarian cancer families and half of the early-onset breast cancer families are linked to markers on 17q (BRCA1). While linkage has been demonstrated in families with premenopausal disease, few studies have tested these markers in families with postmenopausal breast cancer. In the Iowa Women`s Health Study, a population-based study of over 42,000 women, an association of waist-to-hip ratio (WHR) with the risk of postmenopausal breast cancer was found predominantly in women with a positive family history -- this interaction was associated with a 3.2-fold elevated risk. This effect was even more pronounced when the definition of family history included breast and ovarian cancer, known to be linked to 17q markers. We evaluated evidence for linkage with D17S579, a BRCA-1-linked marker, in 13 families in which the index case had postmenopausal breast cancer. Genotyping for alleles at D17S579 was performed on 84 blood samples. Linkage analysis assumed that the breast cancer trait had an autosomal dominant mode of inheritance with a penetrance of 80%. For the 13 families studied, the maximum lod score was 0.29 at a theta of 0.27. There was significant evidence against tight linkage of breast cancer with D17S579 (theta<0.4). Heterogeneity analysis suggested evidence for the presence of both linked and unlinked families. Partitioning informative families on WHR of the index case suggested heterogeneity. These data suggest that, in a subset of families identified by a postmenopausal breast cancer proband, risk of breast cancer may be mediated by BRCA1, with heterogeneity defined by WHR.

  2. Algorithms for Fluorescence Lifetime Microscopy and Optical Coherence Tomography Data Analysis: Applications for Diagnosis of Atherosclerosis and Oral Cancer 

    E-Print Network [OSTI]

    Pande, Paritosh

    2014-05-16

    in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Chair of Committee, Javier A. Jo Committee Members, Brian E. Applegate Kristen C. Maitland Byung-Jun Yoon Head of Department, Gerard L. Cote´ August 2014 Major Subject...

  3. AT NORTHWESTERN EARLY CANCER DETECTION

    E-Print Network [OSTI]

    Chisholm, Rex L.

    --including lung cancer, pancreatic cancer, and ovarian cancer-- there is simply no screening option available, such as pancreatic, ovarian, and lung cancer. · Improve existing screening techniques, such as those for colon cancer, with the THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE EARLY CANCER DETECTION TECHNOLOGIES INSTITUTE

  4. Pretreatment [{sup 18}F]-fluoro-2-deoxy-glucose Positron Emission Tomography Maximum Standardized Uptake Value as Predictor of Distant Metastasis in Early-Stage Non-Small Cell Lung Cancer Treated With Definitive Radiation Therapy: Rethinking the Role of Positron Emission Tomography in Personalizing Treatment Based on Risk Status

    SciTech Connect (OSTI)

    Nair, Vimoj J.; MacRae, Robert; Sirisegaram, Abby; Pantarotto, Jason R.

    2014-02-01

    Purpose: The aim of this study was to determine whether the preradiation maximum standardized uptake value (SUV{sub max}) of the primary tumor for [{sup 18}F]-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) has a prognostic significance in patients with Stage T1 or T2N0 non-small cell lung cancer (NSCLC) treated with curative radiation therapy, whether conventional or stereotactic body radiation therapy (SBRT). Methods and Materials: Between January 2007 and December 2011, a total of 163 patients (180 tumors) with medically inoperable histologically proven Stage T1 or T2N0 NSCLC and treated with radiation therapy (both conventional and SBRT) were entered in a research ethics board approved database. All patients received pretreatment FDG-PET / computed tomography (CT) at 1 institution with consistent acquisition technique. The medical records and radiologic images of these patients were analyzed. Results: The overall survival at 2 years and 3 years for the whole group was 76% and 67%, respectively. The mean and median SUV{sub max} were 8.1 and 7, respectively. Progression-free survival at 2 years with SUV{sub max} <7 was better than that of the patients with tumor SUV{sub max} ?7 (67% vs 51%; P=.0096). Tumors with SUV{sub max} ?7 were associated with a worse regional recurrence-free survival and distant metastasis-free survival. In the multivariate analysis, SUV{sub max} ?7 was an independent prognostic factor for distant metastasis-free survival. Conclusion: In early-stage NSCLC managed with radiation alone, patients with SUV{sub max} ?7 on FDG-PET / CT scan have poorer outcomes and high risk of progression, possibly because of aggressive biology. There is a potential role for adjuvant therapies for these high-risk patients with intent to improve outcomes.

  5. Risk Dynamics?An Analysis for the Risk of Change

    E-Print Network [OSTI]

    Huang, Tailin

    2010-01-01

    Risk Assessment?" Risk Analysis, Aubrey, A. (2010). "T. (2003). Foundations of Risk Analysis : A Knowledge andNJ. Ayyub, B. M. (2003). Risk Analysis in Engineering and

  6. Predicting the Remaining Useful Lifetime of a Proton Exchange Membrane Fuel Cell using an Echo State Network

    E-Print Network [OSTI]

    Boyer, Edmond

    1 Predicting the Remaining Useful Lifetime of a Proton Exchange Membrane Fuel Cell using an Echo industrial Fuel Cell (FC) application resides in the system limited useful lifetime. Consequently, it Membrane Fuel Cell using an iterative predictive structure, which is the most common approach performing

  7. Energy-efficient Search for Finite-lifetime Resources in Sensor Networks with Time-constrained Queries

    E-Print Network [OSTI]

    Kharoufeh, Jeffrey P.

    Energy-efficient Search for Finite-lifetime Resources in Sensor Networks with Time to the originating node prior to the expiration of a specific deadline. From the per- spective of energy efficiency networks when resources are subject to limited lifetimes and queries are constrained by application

  8. Extending the Lifetime of Fuel Cell Based Hybrid Systems* Jianli Zhuo1, Chaitali Chakrabartil, Naehyuck Chang2, Sarma Vrudhula3

    E-Print Network [OSTI]

    Kambhampati, Subbarao

    34.1 Extending the Lifetime of Fuel Cell Based Hybrid Systems* Jianli Zhuo1, Chaitali Chakrabartil@asu.edu ABSTRACT for portable applications. Fuel cells have very high energy densities Fuel cells are clean power densities and lifetimes compared to batteries. However, fuel cells

  9. Supervised learning of a regression model based on latent process. Application to the estimation of Fuel Cell lifetime

    E-Print Network [OSTI]

    Chamroukhi, Faicel

    of Fuel Cell lifetime Raďssa Onanena(1), Faicel Chamroukhi(1), Latifa Oukhellou(1), Denis Candusso(1 A probabilistic approach Parameter estimation 3 Fuel Cell lifetime estimation 4 Conclusion Faicel Chamroukhi maintenance of the Fuel Cells (FCs) Fuel Cells (FCs) are widely used in many domains including transport

  10. Risk and robust optimization

    E-Print Network [OSTI]

    Brown, David Benjamin, Ph. D. Massachusetts Institute of Technology

    2006-01-01

    This thesis develops and explores the connections between risk theory and robust optimization. Specifically, we show that there is a one-to-one correspondence between a class of risk measures known as coherent risk measures ...

  11. Why Risk Assessment? Because ...

    E-Print Network [OSTI]

    Střlen, Ketil

    Why Risk Assessment? Because ... CORAS is committed to supporting international industry can take advantage of the CORAS technology in order to give their mission critical risk assessment assessment methodology integrating techniques and features from partly complementary risk assessment methods

  12. CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER

    E-Print Network [OSTI]

    Sherman, S. Murray

    CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

  13. Cancer Stage at Diagnosis, 2013

    E-Print Network [OSTI]

    2013-01-01

    of avoiding death due to a particular cancer. Stage atdiagnosis by the American Joint Committee on Cancer (AJCC) Cancer Staging Manual, sixth edition. Source:

  14. The development of a sensitive method to study volatile organic compounds in gaseous emissions of lung cancer cell lines 

    E-Print Network [OSTI]

    Maroly, Anupam

    2005-08-29

    ]. Workers exposed to tar and soot (which contains benzo[a]pyrene), such as coke oven workers, [7, 8] in concentrations exceeding those present in urban air are at increased risk of lung cancer. Occupational exposures to a number of metals, including... detection of lung cancer. Tests involved the quantitation of gaseous metabolic emissions from immortalized lung cancer cell lines in order to correlate the chemical markers to be of cancerous origin. The specific aims of the project were the study of gas...

  15. BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PL LDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN

    E-Print Network [OSTI]

    Florida, University of

    BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PL LDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN BUILDING A R RISK MANAGEMENT PLAN BUILDING A RISK MANAGEMENT PLAN BUILDIN T PLAN BUILDING A RISK MANAGEMENT PLAN BUILDING A RISK MANAGEM

  16. Enterprise Risk Management Framework

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Framework The Enterprise Risk Management (ERM) framework includes four steps: identify the risks, determine the probability and impact of each one, identify controls that are...

  17. Development of New Treatments for Prostate Cancer

    SciTech Connect (OSTI)

    DiPaola, R. S.; Abate-Shen, C.; Hait, W. N.

    2005-02-01

    The Dean and Betty Gallo Prostate Cancer Center (GPCC) was established with the goal of eradicating prostate cancer and improving the lives of men at risk for the disease through research, treatment, education and prevention. GPCC was founded in the memory of Dean Gallo, a beloved New Jersey Congressman who died tragically of prostate cancer diagnosed at an advanced stage. GPCC unites a team of outstanding researchers and clinicians who are committed to high-quality basic research, translation of innovative research to the clinic, exceptional patient care, and improving public education and awareness of prostate cancer. GPCC is a center of excellence of The Cancer Institute of New Jersey, which is the only NCI-designated comprehensive cancer center in the state. GPCC efforts are now integrated well as part of our Prostate Program at CINJ, in which Dr. Robert DiPaola and Dr. Cory Abate-Shen are co-leaders. The Prostate Program unites 19 investigators from 10 academic departments who have broad and complementary expertise in prostate cancer research. The overall goal and unifying theme is to elucidate basic mechanisms of prostate growth and oncogenesis, with the ultimate goal of promoting new and effective strategies for the eradication of prostate cancer. Members' wide range of research interests collectively optimize the chances of providing new insights into normal prostate biology and unraveling the molecular pathophysiology of prostate cancer. Cell culture and powerful animal models developed by program members recapitulate the various stages of prostate cancer progression, including prostatic intraepithelial neoplasia, adenocarcinoma, androgen-independence, invasion and metastases. These models promise to further strengthen an already robust program of investigator-initiated therapeutic clinical trials, including studies adopted by national cooperative groups. Efforts to translate laboratory results into clinical studies of early detection and chemoprevention are underway. The specific goals of this program are: (1) To investigate the molecular mechanisms underlying normal prostate growth and differentiation and elucidate the molecular mechanisms underlying prostate oncogenesis. (2) To build on fundamental knowledge to develop effective therapeutic approaches for the treatment of prostate cancer. (3) To improve the control of prostate cancer through early detection, chemoprevention, and outreach and education. This new disease-based program is structured to improve interdisciplinary interactions and translational results. Already, through the dynamic leadership of Drs. Cory Abate-Shen and Robert DiPaola, new investigators were attracted to the field, new collaborations engendered, and numerous investigator-initiated trials implemented. Progress in GPCC and the program overall has been outstanding. The Center has success in uniting investigators with broad and complementary expertise in prostate cancer research. The overall goal and unifying theme is to elucidate basic mechanisms of prostate growth and oncogenesis, with the ultimate goal of promoting new and effective strategies for the eradication of prostate cancer in patients and populations at risk. Members wide range of research interests collectively optimize the chances of providing new insights into normal prostate biology and unraveling the molecular pathophysiology of prostate cancer. Studies in cell culture and powerful animal models developed recapitulate the various stages of prostate cancer progression, including prostatic intraepithelial neoplasia, adenocarcinoma, androgen-independence, invasion and metastases. These models promise to further strengthen an already robust program of investigator-initiated therapeutic clinical trials, including studies adopted by national cooperative groups. Efforts to translate laboratory results into clinical studies of early detection and chemoprevention are underway.

  18. Estrogenic Properties of Sorghum Phenolics: Possible Role in Colon Cancer Prevention 

    E-Print Network [OSTI]

    Yang, Liyi

    2013-07-03

    Consumption of whole grains has been linked to reduced risk of colon cancer. This study determined estrogenic activity of sorghum phenolic extracts of different phenolic profiles and identified possible estrogenic compounds in sorghum in vitro...

  19. Investigating the role of vitamin D and DNA repair in influencing cancer presentation and outcomes 

    E-Print Network [OSTI]

    Varrier, Shilpa

    2015-04-23

    Recent studies have identified differences in cancer risk, severity, and response to treatments in different ethnic groups. When comparing Americans of African descent to those of Caucasian descent, symptoms in African American patients were...

  20. Investigating the role of vitamin D and DNA repair in influencing cancer presentation and outcome 

    E-Print Network [OSTI]

    Pidaparti, Divya

    2015-04-24

    Recent studies have identified differences in cancer risk, severity, and response to treatments in different ethnic groups. When comparing Americans of African descent to those of Caucasian descent, symptoms in African American patients were...

  1. Investigating the role of vitamin D and DNA repair in influencing cancer presentation and outcome 

    E-Print Network [OSTI]

    Stonecipher, Ashley

    2015-04-23

    Recent studies have identified differences in cancer risk, severity, and response to treatments in different ethnic groups. When comparing Americans of African descent to those of Caucasian descent, symptoms in African American patients were...

  2. Metabolic Syndrome, Vitamin D Status, and the Incidence of Prostate Cancer

    E-Print Network [OSTI]

    Rorabaugh, Joseph Randall

    2012-08-31

    ABSTRACT Background: Epidemiologic data on the role of metabolic syndrome on prostate cancer risk is inconsistent, and only one case-control trial has examined the combined relationship of metabolic syndrome and vitamin D deficiency. Objective...

  3. Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer

    E-Print Network [OSTI]

    Green, Todd

    The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors.1 To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we ...

  4. Variation in Use of Androgen Suppression With External-Beam Radiotherapy for Nonmetastatic Prostate Cancer

    SciTech Connect (OSTI)

    Swisher-McClure, Samuel; Pollack, Craig E.; Christodouleas, John P.; Guzzo, Thomas J.; Haas, Naomi B.; Vapiwala, Neha; Bekelman, Justin E.

    2012-05-01

    Purpose: To describe practice patterns associated with androgen suppression (AS) stratified by disease risk group in patients undergoing external-beam radiotherapy (EBRT) for localized prostate cancer. Methods and Materials: We identified 2,184 low-risk, 2,339 intermediate-risk, and 2,897 high-risk patients undergoing EBRT for nonmetastatic prostate cancer diagnosed between January 1, 2004, and December 31, 2005, in the linked Surveillance, Epidemiology, and End Results-Medicare database. We examined the association of patient, clinical, and demographic characteristics with AS use by multivariate logistic regression. Results: The proportions of patients receiving AS for low-risk, intermediate-risk, and high-risk prostate cancer were 32.2%, 56.3%, and 81.5%, respectively. AS use among men in the low-risk disease category varied widely, ranging from 13.6% in Detroit to 47.8% in Kentucky. We observed a significant decline in AS use between 2004 and 2005 within all three disease risk categories. Men aged {>=}75 years or with elevated comorbidity levels were more likely to receive AS. Conclusion: Our results identified apparent overuse and underuse of AS among men within the low-risk and high-risk disease categories, respectively. These results highlight the need for clinician and patient education regarding the appropriate use of AS. Practice patterns among intermediate-risk patients reflect the clinical heterogeneity of this population and underscore the need for better evidence to guide the treatment of these patients.

  5. RISK JOURNALS CATALOGUE 2015 www.risk.net/journal

    E-Print Network [OSTI]

    RISK JOURNALS CATALOGUE 2015 www.risk.net/journal #12;Risk Journals deliver academically rigorous accurately. DISCOVER RISK JOURNALS HOW CAN RISK JOURNALS HELP YOU? www.risk.net/journal Risk Journals deliver strategies, commodities, infrastructures, derivatives, regulation and more. Each quarter Risk Journals

  6. Risk Assessment Sally Brown

    E-Print Network [OSTI]

    Brown, Sally

    or publicly owned treatment works) whose regulations and rule enforcement work to make sure that the risksRisk Assessment Sally Brown University of Washington Risk in our day to day routines One could argue that every thing that we do, every day is fraught with risks and that the safest approach is just

  7. Risk Assessment Fact Sheet

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Risk Assessment ® Fact Sheet U.S. Army Corps of Engineers Building Strong ® Buffalo District June 2012 Risk Assessment A risk assessment is performed for hazardous, toxic, and radioactive waste sites and chemicals in the environment. Information from the risk assessment is used to determine whether action

  8. Theory of SEI Formation in Rechargeable Batteries: Capacity Fade, Accelerated Aging and Lifetime Prediction

    E-Print Network [OSTI]

    Pinson, Matthew B

    2012-01-01

    Cycle life is critically important in applications of rechargeable batteries, but lifetime prediction is mostly based on empirical trends, rather than mathematical models. In practical lithium-ion batteries, capacity fade occurs over thousands of cycles, limited by slow electrochemical processes, such as the formation of a solid-electrolyte interphase (SEI) in the negative electrode, which compete with reversible lithium intercalation. Focusing on SEI growth as the canonical degradation mechanism, we show that a simple single-particle model can accurately explain experimentally observed capacity fade in commercial cells with graphite anodes, and predict future fade based on limited accelerated aging data for short times and elevated temperatures. The theory is extended to porous electrodes, predicting that SEI growth is essentially homogeneous throughout the electrode, even at high rates. The lifetime distribution for a sample of batteries is found to be consistent with Gaussian statistics, as predicted by th...

  9. Alignments Of Black Holes With Their Warped Accretion Disks And Episodic Lifetimes Of Active Galactic Nuclei

    E-Print Network [OSTI]

    Li, Yan-Rong; Cheng, Cheng; Qiu, Jie

    2015-01-01

    Warped accretion disks have attracted intensive attention because of their critical role on shaping the spin of supermassive massive black holes (SMBHs) through the Bardeen-Petterson effect, a general relativistic effect that leads to final alignments or anti-alignments between black holes and warped accretion disks. We study such alignment processes by explicitly taking into account the finite sizes of accretion disks and the episodic lifetimes of AGNs that delineate the duration of gas fueling onto accretion disks. We employ an approximate global model to simulate the evolution of accretion disks, allowing to determine the gravitomagnetic torque that drives the alignments in a quite simple way. We then track down the evolutionary paths for mass and spin of black holes both in a single activity episode and over a series of episodes. Given with randomly and isotropically oriented gas fueling over episodes, we calculate the spin evolution with different episodic lifetimes and find that it is quite sensitive to...

  10. Apparatus and method for measuring minority carrier lifetimes in semiconductor materials

    DOE Patents [OSTI]

    Ahrenkiel, Richard K. (Lakewood, CO); Johnston, Steven W. (Golden, CO)

    2001-01-01

    An apparatus for determining the minority carrier lifetime of a semiconductor sample includes a positioner for moving the sample relative to a coil. The coil is connected to a bridge circuit such that the impedance of one arm of the bridge circuit is varied as sample is positioned relative to the coil. The sample is positioned relative to the coil such that any change in the photoconductance of the sample created by illumination of the sample creates a linearly related change in the input impedance of the bridge circuit. In addition, the apparatus is calibrated to work at a fixed frequency so that the apparatus maintains a consistently high sensitivity and high linearity for samples of different sizes, shapes, and material properties. When a light source illuminates the sample, the impedance of the bridge circuit is altered as excess carriers are generated in the sample, thereby producing a measurable signal indicative of the minority carrier lifetimes or recombination rates of the sample.

  11. Preliminary lifetime predictions for 304 stainless steel as the LANL ABC blanket material

    SciTech Connect (OSTI)

    Park, J.J.; Buksa, J.J.; Houts, M.G.; Arthur, E.D.

    1997-11-01

    The prediction of materials lifetime in the preconceptual Los Alamos National Laboratory (LANL) Accelerator-Based Conversion of Plutonium (ABC) is of utmost interest. Because Hastelloy N showed good corrosion resistance to the Oak Ridge National Laboratory Molten Salt Reactor Experiment fuel salt that is similar to the LANL ABC fuel salt, Hastelloy N was originally proposed for the LANL ABC blanket material. In this paper, the possibility of using 304 stainless steel as a replacement for the Hastelloy N is investigated in terms of corrosion issues and fluence-limit considerations. An attempt is made, based on the previous Fast Flux Test Facility design data, to predict the preliminary lifetime estimate of the 304 stainless steel used in the blanket region of the LANL ABC.

  12. Heating rate and spin flip lifetime due to near field noise in layered superconducting atom chips

    E-Print Network [OSTI]

    Rachele Fermani; Tobias Mueller; Bo Zhang; Michael J. Lim; Rainer Dumke

    2009-12-11

    We theoretically investigate the heating rate and spin flip lifetimes due to near field noise for atoms trapped close to layered superconducting structures. In particular, we compare the case of a gold layer deposited above a superconductor with the case of a bare superconductor. We study a niobium-based and a YBCO-based chip. For both niobium and YBCO chips at a temperature of 4.2 K, we find that the deposition of the gold layer can have a significant impact on the heating rate and spin flip lifetime, as a result of the increase of the near field noise. At a chip temperature of 77 K, this effect is less pronounced for the YBCO chip.

  13. Phosphazene Based Additives for Improvement of Safety and Battery Lifetimes in Lithium-Ion Batteries

    SciTech Connect (OSTI)

    Mason K Harrup; Kevin L Gering; Harry W Rollins; Sergiy V Sazhin; Michael T Benson; David K Jamison; Christopher J Michelbacher

    2011-10-01

    There need to be significant improvements made in lithium-ion battery technology, principally in the areas of safety and useful lifetimes to truly enable widespread adoption of large format batteries for the electrification of the light transportation fleet. In order to effect the transition to lithium ion technology in a timely fashion, one promising next step is through improvements to the electrolyte in the form of novel additives that simultaneously improve safety and useful lifetimes without impairing performance characteristics over wide temperature and cycle duty ranges. Recent efforts in our laboratory have been focused on the development of such additives with all the requisite properties enumerated above. We present the results of the study of novel phosphazene based electrolytes additives.

  14. Radiative lifetime and energy of the low-energy isomeric level in $^{229}$Th

    E-Print Network [OSTI]

    Tkalya, E V; Jeet, Justin; Hudson, Eric R

    2015-01-01

    We estimate the range of the radiative lifetime and energy of the anomalous, low-energy $3/2^+(7.8 \\pm 0.5$ eV) state in the $^{229}$Th nucleus. Our phenomenological calculations are based on the available experimental data for the intensities of $M1$ and $E2$ transitions between excited levels of the $^{229}$Th nucleus in the $K^{\\pi}[Nn_Z\\Lambda]=5/2^+[633]$ and $3/2^+[631]$ rotational bands. We also discuss the influence of certain branching coefficients, which affect the currently accepted measured energy of the isomeric state. From this work, we establish a favored region where the transition lifetime and energy should lie at roughly the 90% confidence level. We also suggest new nuclear physics measurements, which would significantly reduce the ambiguity in the present data.

  15. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

    E-Print Network [OSTI]

    2006-01-01

    1996): Nutrition and breast cancer. Cancer Causes Control 7:of premenopausal breast cancer. Cancer Epidemiol.BiomarkersDiagnosis Weight Gain and Breast Cancer Recurrence In Women

  16. Risk communications & emergency planning

    SciTech Connect (OSTI)

    Baranski, S.C. [EQUINOX Environmental, Inc., Shushan, NY (United States)

    1995-12-31

    This talk outlines the interface between good risk communication and emergency planning. The major topics include the following: What is risk communication and how is it applied to emergency planning; crisis communication and the need to know and how to integrate crisis communication and risk communication; the face of the emergency: spokespersons, public information; The Media`s role in emergency Public information and risk communication; Developing the risk communication message; How to respond to continuing need for 24 hours communications; the EAS and Risk communication and Crisis communication; and finally where is risk communication heading and how it can help.

  17. Paul Sellin, Centre for Nuclear and Radiation Physics Mobility and lifetime mapping in wide bandgap

    E-Print Network [OSTI]

    Sellin, Paul

    Paul Sellin, Centre for Nuclear and Radiation Physics Mobility and lifetime mapping in wide bandgap uniformity #12;Paul Sellin, Centre for Nuclear and Radiation Physics µ mapping in CdZnTe with IBIC Electron µ for Nuclear and Radiation Physics µ maps of CdZnTe and CdTe CdZnTe CdTe Map of electron µ in CdZnTe shows µe

  18. Investigation of in-vivo skin autofluorescence lifetimes under long-term cw optical excitation

    SciTech Connect (OSTI)

    Lihachev, A; Ferulova, I; Vasiljeva, K; Spigulis, J

    2014-08-31

    The main results obtained during the last five years in the field of laser-excited in-vivo human skin photobleaching effects are presented. The main achievements and results obtained, as well as methods and experimental devices are briefly described. In addition, the impact of long-term 405-nm cw low-power laser excitation on the skin autofluorescence lifetime is experimentally investigated. (laser biophotonics)

  19. Lifetime of oil drops pressed by buoyancy against a planar interface: Large drops

    E-Print Network [OSTI]

    Clara Rojas; Máximo García-Sucre; Germán Urbina-Villalba

    2011-09-22

    In a previous report [10] it was shown that emulsion stability simulations are able to reproduce the lifetime of micrometer-size drops of hexadecane pressed by buoyancy against a planar water-hexadecane interface. It was confirmed that small drops (rioil stabilized with bovine serum albumin. The potential obtained is then employed to study the lifetime of deformable drops in the range 10 \\leq ri \\leq 1000 {\\mu}m. It is established that the average lifetime of these drops can be adequately replicated using the model of truncated spheres. However, the results depend sensibly on the expressions of the initial distance of deformation and the maximum film radius used in the calculations. The set of equations adequate for large drops is not satisfactory for medium-size drops (10 \\leq ri \\leq 100 {\\mu}m), and vice versa. In the case of large particles, the increase in the interfacial area as a consequence of the deformation of the drops generates a very large repulsive barrier which opposes coalescence. Nevertheless, the buoyancy force prevails. As a consequence, it is the hydrodynamic tensor of the drops which determine the characteristic behavior of the lifetime as a function of the particle size. While the average values of the coalescence time of the drops can be justified by the mechanism of film thinning, the scattering of the experimental data of large drops cannot be rationalized using the methodology previously described. A possible explanation of this phenomenon required elaborate simulations which combine deformable drops, capillary waves, repulsive interaction forces, and a time-dependent surfactant adsorption.

  20. Bounds for Lifetime Maximization with Multiple Sinks in Wireless Sensor Networks

    E-Print Network [OSTI]

    Wong, Vincent

    in the literature (e.g., [2], [3]). The network lifetime in a WSN can be defined as the time at which the first node-sink WSN. In [9], Oyman and Ersoy used multiple sinks to reduce the energy consumption of WSN. The network-efficient routing for multi-sink WSNs. In this scheme, each partition in the WSN has one sink and the source only

  1. Vibrational lifetimes and vibrational line positions in polyatomic supercritical fluids near the critical point

    E-Print Network [OSTI]

    Fayer, Michael D.

    of the asymmetric (T1u) CO stretching mode of W CO 6 in supercritical CO2, C2H6, and CHF3 as a function of solvent spectra of W CO 6 and Rh CO 2acac in supercritical CO2, C2H6, and CHF3 acquired for the same isothermsVibrational lifetimes and vibrational line positions in polyatomic supercritical fluids near

  2. Breakdown of the photon lifetime concept in optical cavities with negative group delay

    E-Print Network [OSTI]

    Lauprętre, T; Ghosh, R; Carusotto, I; Goldfarb, F; Bretenaker, F

    2011-01-01

    The concept of photon lifetime in a cavity is shown to be non-relevant in the case where the cavity round-trip group delay is negative due to the presence of a strong intracavity negative dispersion. Causality is shown to forbid the cavity spectrum from being a single Lorentzian. These features are tested experimentally using intracavity detuned electromagnetically induced transparency in room-temperature metastable helium.

  3. Mechanistic Investigation of Tolfenamic Acid, Betulinic Acid, and Aspirin in Anti-Cancer Therapy 

    E-Print Network [OSTI]

    Liu, Xinyi

    2012-10-19

    to high levels of certain aromatic amines, the N-acetyltransferase (NAT2) slow acetylator phenotype confers a higher risk of bladder cancer [17]. Mutations in glutathione S- transferase genes are associated with increased lung cancer risk [18... proto-oncogene and its corresponding protein product. For example, amplification of the N-myc proto-oncogene has been linked to a number of human neuroblastomas, retinoblastomas, small cell lung carcinomas, and astrocytomas [23]; ErbB2 amplifications...

  4. Familial Breast Cancer Julie Saffarian

    E-Print Network [OSTI]

    Brutlag, Doug

    Familial Breast Cancer Julie Saffarian Genomics & Medicine Stanford University #12;Definitions metastasis" ­ Wikipedia.com What is Breast Cancer? - Breast Cancer is a disease in which the uncontrollable Breast Cancer? - Sporadic Breast Cancer is non-hereditary and represents 85-90% of Cancer cases

  5. 505: New Mass and Lifetime of the \\Xi + Sergio P. Ratti (for the E687 Collaboration ? ) (ratti@pv.infn.it)

    E-Print Network [OSTI]

    Ratti, Sergio P.

    505: New Mass and Lifetime of the \\Xi + c Sergio P. Ratti (for the E687 Collaboration ? ) (ratti@pv

  6. Analysis of Lifetime Data for the Linac 201 MHz Power Amplifiers

    SciTech Connect (OSTI)

    Elliot McCrory and Robert C. Webber

    2002-07-09

    This document analyzes data on the lifetime of the 201-MHz triode power amplifier (PA) vacuum tube, model number 7835, used in the low-energy half of the Linac. We observe that a 7835 power amplifier vacuum tube has historically provided about one and one-third years service in the Linac. The lifetime of recently re-manufactured tubes is somewhat less, but it is not clear if this is because the manufacturer is ''loosing their touch,'' or because tubes cannot be effectively rebuilt after a certain number of times. Taking into account the expected tube lifetimes, the statistical fluctuations on this number, and the amount of time it takes for the manufacturer to make good tubes, we require about 14 tubes either operating, ready as good spares or being manufactured, in order to have sufficient spares to run the Linac. As a hedge against supplier drop out, we need to increase our inventory of good spare tubes by about three tubes per year for the next few years.

  7. Source fabrication and lifetime for Li+ ion beams extracted from alumino-silicate sources

    SciTech Connect (OSTI)

    Roy, Prabir K.; Greenway, Wayne G.; Kwan, Joe W

    2012-03-05

    A space-charge-limited beam with current densities (J) exceeding 1 mA/cm{sup 2} have been measured from lithium alumino-silicate ion sources at a temperature of #24;~1275#14;{degrees} C. At higher extraction voltages, the source appears to become emission limited with J #21;{>=} 1.5 mA/cm{sup 2}, and J increases weakly with the applied voltage. A 6.35 mm diameter source with an alumino-silicate coating, {<=}#20;0.25 mm thick, has a measured lifetime of ~#24;40 hours at ~#24;1275#14;{degrees} C, when pulsed at 0.05 Hz and with pulse length of #24;~6 μs each. At this rate, the source lifetime was independent of the actual beam charge extracted due to the loss of neutral atoms at high temperature. The source lifetime increases with the amount of alumino-silicate coated on the emitting surface, and may also be further extended if the temperature is reduced between pulses.

  8. Constraining the Lifetime of QSOs with Present-day Mass Function of Supermassive Black Holes

    E-Print Network [OSTI]

    T. Hosokawa

    2002-05-13

    Using the theoretical models of the QSO formation, we can reproduce optical QSO luminosity functions (LFs) at high redshifts (z > 2.2). Two different models can reproduce LFs successfully, though the lifetime of QSOs, t_Q, and the relation between the black hole mass and the host halo mass are different each other; t_Q = 10^6yr, in one model, t_Q > 10^7yr, in other models. Here, we propose a method to break this degeneracy. We calculate the mass function of supermassive black holes (SMBHs) at z=2.5, and compare the result with the current mass function obtained by Salucci et al.(1999). In the shorter lifetime model, the mass function at z=2.5 exceeds that of z=0.0 by one order of magnitude, then it should be ruled out. We conclude that the lifetime is at least t_Q > 10^7yr. Next, we examine the difference of the formation epoch of SMBHs existing at z=3.0 for each model under the model assumptions. We simply discuss the difference of formation epoch as another possible model-discriminator.

  9. Measurement of D0 lifetime with the BaBar detector

    SciTech Connect (OSTI)

    Simi, Gabriele; /Pisa U. /SLAC

    2009-12-17

    This work is the result of the researchers carried out during a three years Ph.D. period in the BABAR experiment. The first chapter consists in an introduction to the theoretical aspects of the D{sup 0} meson lifetime determination and CP violation parameters, as well as an overview of the CP violation in the B sector, which is the main topic of the experiment. The description of the experimental apparatus follows with particular attention to the Silicon Vertex Tracker detector, the most critical detector for the determination of decay vertices and thus of lifetimes and time dependent CP violation asymmetries. In the fourth chapter the operation and running of the vertex detector is described, as a result from the experience as Operation Manager of the SVT, with particular attention to the safety of the device and the data quality assurance. The last chapter is dedicated to the determination of the D{sup 0} meson lifetime with the BABAR detector, which is the main data analysis carried out by the candidate. The analysis is characterized by the selection of an extremely pure sample of D{sup 0} mesons for which the decay flight length and proper time is reconstructed. The description of the unbinned maximum likelihood fit follows, as well as the discussion of the possible sources of systematic uncertainties. In the appendix is also presented a preliminary study of a possible development regarding the determination of mixing and CP violation parameters for the D{sup 0} meson.

  10. Studies of unicellular micro-organisms Saccharomyces cerevisiae by means of Positron Annihilation Lifetime Spectroscopy

    E-Print Network [OSTI]

    Kubicz, E; Zgardzi?ska, B; Bednarski, T; Bia?as, P; Czerwi?ski, E; Gajos, A; Gorgol, M; Kami?ska, D; Kap?on, ?; Kochanowski, A; Korcyl, G; Kowalski, P; Kozik, T; Krzemie?, W; Nied?wiecki, S; Pa?ka, M; Raczy?ski, L; Rajfur, Z; Rudy, Z; Rundel, O; Sharma, N G; Silarski, M; S?omski, A; Strzelecki, A; Wieczorek, A; Wi?licki, W; Zieli?ski, M; Moskal, P

    2015-01-01

    Results of Positron Annihilation Lifetime Spectroscopy (PALS) and microscopic studies on simple microorganisms: brewing yeasts are presented. Lifetime of ortho - positronium (o-Ps) were found to change from 2.4 to 2.9 ns (longer lived component) for lyophilised and aqueous yeasts, respectively. Also hygroscopicity of yeasts in time was examined, allowing to check how water - the main component of the cell - affects PALS parameters, thus lifetime of o-Ps were found to change from 1.2 to 1.4 ns (shorter lived component) for the dried yeasts. The time sufficient to hydrate the cells was found below 10 hours. In the presence of liquid water an indication of reorganization of yeast in the molecular scale was observed. Microscopic images of the lyophilised, dried and wet yeasts with best possible resolution were obtained using Inverted Microscopy (IM) and Environmental Scanning Electron Microscopy (ESEM) methods. As a result visible changes to the surface of the cell membrane were observed in ESEM images.

  11. Measurement of the B-cmeson lifetime in the decay B-c?J/???

    SciTech Connect (OSTI)

    Aaltonen, T.; Álvarez González, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J. A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Auerbach, B.; Aurisano, A.; Azfar, F.; Badgett, W.; Bae, T.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauce, M.; Bedeschi, F.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Bisello, D.; Bizjak, I.; Bland, K. R.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brigliadori, L.; Bromberg, C.; Brucken, E.; Budagov, J.; Budd, H. S.; Burkett, K.; Busetto, G.; Bussey, P.; Buzatu, A.; Calamba, A.; Calancha, C.; Camarda, S.; Campanelli, M.; Campbell, M.; Canelli, F.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Carron, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Chlebana, F.; Cho, K.; Chokheli, D.; Chung, W. H.; Chung, Y. S.; Ciocci, M. A.; Clark, A.; Clarke, C.; Compostella, G.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Crescioli, F.; Cuevas, J.; Culbertson, R.; Dagenhart, D.; d’Ascenzo, N.; Datta, M.; de Barbaro, P.; Dell’Orso, M.; Demortier, L.; Deninno, M.; Devoto, F.; d’Errico, M.; Di Canto, A.; Di Ruzza, B.; Dittmann, J. R.; D’Onofrio, M.; Donati, S.; Dong, P.; Dorigo, M.; Dorigo, T.; Ebina, K.; Elagin, A.; Eppig, A.; Erbacher, R.; Errede, S.; Ershaidat, N.; Eusebi, R.; Farrington, S.; Feindt, M.; Fernandez, J. P.; Field, R.; Flanagan, G.; Forrest, R.; Frank, M. J.; Franklin, M.; Freeman, J. C.; Funakoshi, Y.; Furic, I.; Gallinaro, M.; Garcia, J. E.; Garfinkel, A. F.; Garosi, P.; Gerberich, H.; Gerchtein, E.; Giagu, S.; Giakoumopoulou, V.; Giannetti, P.; Gibson, K.; Ginsburg, C. M.; Giokaris, N.; Giromini, P.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldin, D.; Goldschmidt, N.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Guimaraes da Costa, J.; Hahn, S. R.; Halkiadakis, E.; Hamaguchi, A.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, D.; Hare, M.; Harr, R. F.; Hatakeyama, K.; Hays, C.; Heck, M.; Heinrich, J.; Herndon, M.; Hewamanage, S.; Hocker, A.; Hopkins, W.; Horn, D.; Hou, S.; Hughes, R. E.; Hurwitz, M.; Husemann, U.; Hussain, N.; Hussein, M.; Huston, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jindariani, S.; Jones, M.; Joo, K. K.; Jun, S. Y.; Junk, T. R.; Kamon, T.; Karchin, P. E.; Kasmi, A.; Kato, Y.; Ketchum, W.; Keung, J.; Khotilovich, V.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. B.; Kim, S. H.; Kim, Y. K.; Kim, Y. J.; Kimura, N.; Kirby, M.; Klimenko, S.; Knoepfel, K.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Krop, D.; Kruse, M.; Krutelyov, V.; Kuhr, T.; Kurata, M.; Kwang, S.; Laasanen, A. T.; Lami, S.; Lammel, S.; Lancaster, M.; Lander, R. L.; Lannon, K.; Lath, A.; Latino, G.; LeCompte, T.; Lee, E.; Lee, H. S.; Lee, J. S.; Lee, S. W.; Leo, S.; Leone, S.; Lewis, J. D.; Limosani, A.; Lin, C.-J.; Lindgren, M.; Lipeles, E.; Lister, A.; Litvintsev, D. O.; Liu, C.; Liu, H.; Liu, Q.; Liu, T.; Lockwitz, S.; Loginov, A.; Lucchesi, D.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; Madrak, R.; Maeshima, K.; Maestro, P.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Margaroli, F.; Marino, C.; Martínez, M.; Mastrandrea, P.; Matera, K.; Mattson, M. E.; Mazzacane, A.; Mazzanti, P.; McFarland, K. S.; McIntyre, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Mesropian, C.; Miao, T.; Mietlicki, D.; Mitra, A.; Miyake, H.; Moed, S.; Moggi, N.; Mondragon, M. N.; Moon, C. S.; Moore, R.; Morello, M. J.; Morlock, J.; Movilla Fernandez, P.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Neubauer, M. S.; Nielsen, J.; Nodulman, L.; Noh, S. Y.; Norniella, O.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Ortolan, L.; Pagan Griso, S.; Pagliarone, C.; Palencia, E.; Papadimitriou, V.; Paramonov, A. A.; Patrick, J.; Pauletta, G.; Paulini, M.; Paus, C.; Pellett, D. E.; Penzo, A.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pilot, J.; Pitts, K.; Plager, C.; Pondrom, L.; Poprocki, S.; Potamianos, K.; Prokoshin, F.; Pranko, A.; Ptohos, F.; Punzi, G.; Rahaman, A.; Ramakrishnan, V.; Ranjan, N.; Redondo, I.; Renton, P.; Rescigno, M.; Riddick, T.; Rimondi, F.; Ristori, L.; Robson, A.; Rodrigo, T.; Rodriguez, T.; Rogers, E.; Rolli, S.; Roser, R.; Ruffini, F.; Ruiz, A.; Russ, J.; Rusu, V.; Safonov, A.; Sakumoto, W. K.

    2013-01-01

    The lifetime of the B-c meson is measured using 272 exclusive B-c?J/?(?????)?? decays reconstructed in data from proton-antiproton collisions corresponding to an integrated luminosity of 6.7 fb?ą recorded by the CDF II detector at the Fermilab Tevatron. The lifetime of the B-cmeson is measured to be ?(B-c)=0.452±0.048(stat)±0.027(syst) ps. This is the first measurement of the B-c meson lifetime in a fully reconstructed hadronic channel, and it agrees with previous results and has comparable precision.

  12. Cancer: A suppression switch

    E-Print Network [OSTI]

    Starobinets, H; Debnath, J

    2013-01-01

    Cancer A suppression switch The status of the protein p53it seems that p53 acts as a switch in pancreatic cancer thatthe ability of p53 to switch the clinical outcome of

  13. Comprehensive Cancer Center Nutrition

    E-Print Network [OSTI]

    Anderson, Paul R.

    Comprehensive Cancer Center Nutrition Bldg.Pedestrian Link from Ardmore Tower to Comprehensive Cancer Center on Ground Floor Emergency Room Parking Pedestrian Link to Parking on 4th Floor Surgical

  14. Final Report DOE Grant# DE-FG02-98ER62592: Second Cancers, Tumor p53, and Archaea Research

    SciTech Connect (OSTI)

    Samuel M. Lesko, MD, MPH

    2006-01-14

    The Northeast Regional Cancer Institute conducted cancer surveillance in Northeast Pennsylvania using data from the instituteâ??s population-based regional cancer registry and the Pennsylvania Cancer Registry. The results of this surveillance have been used to set priorities for research and outreach activities at the Cancer Institute and selected results have been reported to medical professionals at member hospitals and in the community. One consistent observation of this surveillance was that colorectal cancer was unusually common in Northeast Pennsylvania; incidence was approximately 25% higher than the rate published for NCIâ??s Surveillance Epidemiology and End Results (SEER) Program. In addition, death rates form colorectal cancer in several counties in this region were above the 90Th percentile for colorectal cancer mortality in the United States. As a result of these observations, several activities have been developed to increase awareness of colorectal cancer and the value of screening for this cancer in both the lay and medical communities. Funding from this grant also provided support for a population-based study of cancer risk factors, screening practices, and related behaviors. This project continues beyond the termination of the present grant with funding from other sources. This project gathers data from a representative sample of adults residing in a six county area of Northeast Pennsylvania. Analyses conducted to date of the established risk factors for colorectal cancer have not revealed an explanation for the high incidence of this cancer in this population.

  15. www.thelancet.com Vol 372 October 25, 2008 1473 Effects of smoking and solid-fuel use on COPD, lung cancer,

    E-Print Network [OSTI]

    Cohen, Ted

    on COPD, lung cancer, and tuberculosis in China: a time-based, multiple risk factor, modelling study Hsien pulmonary disease (COPD), lung cancer, and tuberculosis are three leading causes of death in China, where on COPD, lung cancer, and tuberculosis. Methods We used representative data sources to estimate past

  16. Second Solid Cancers After Radiation Therapy: A Systematic Review of the Epidemiologic Studies of the Radiation Dose-Response Relationship

    SciTech Connect (OSTI)

    Berrington de Gonzalez, Amy; Gilbert, Ethel; Curtis, Rochelle; Inskip, Peter; Kleinerman, Ruth; Morton, Lindsay; Rajaraman, Preetha; Little, Mark P.

    2013-06-01

    Rapid innovations in radiation therapy techniques have resulted in an urgent need for risk projection models for second cancer risks from high-dose radiation exposure, because direct observation of the late effects of newer treatments will require patient follow-up for a decade or more. However, the patterns of cancer risk after fractionated high-dose radiation are much less well understood than those after lower-dose exposures (0.1-5 Gy). In particular, there is uncertainty about the shape of the dose-response curve at high doses and about the magnitude of the second cancer risk per unit dose. We reviewed the available evidence from epidemiologic studies of second solid cancers in organs that received high-dose exposure (>5 Gy) from radiation therapy where dose-response curves were estimated from individual organ-specific doses. We included 28 eligible studies with 3434 second cancer patients across 11 second solid cancers. Overall, there was little evidence that the dose-response curve was nonlinear in the direction of a downturn in risk, even at organ doses of ?60 Gy. Thyroid cancer was the only exception, with evidence of a downturn after 20 Gy. Generally the excess relative risk per Gray, taking account of age and sex, was 5 to 10 times lower than the risk from acute exposures of <2 Gy among the Japanese atomic bomb survivors. However, the magnitude of the reduction in risk varied according to the second cancer. The results of our review provide insights into radiation carcinogenesis from fractionated high-dose exposures and are generally consistent with current theoretical models. The results can be used to refine the development of second solid cancer risk projection models for novel radiation therapy techniques.

  17. PROSTATE CANCER EVIDENCE ACADEMY

    E-Print Network [OSTI]

    Bushman, Frederic

    PROSTATE CANCER EVIDENCE ACADEMY CME/CNE-Certified Course The Inn at Penn 3600 Sansom Street:30 PM R E G I S T E R O N L I N E AT PENNCMEONLINE.COM/NODE/57378 #12;OVERVIEW The Prostate Cancer, and model programs that are proven effective or being studied to improve prostate cancer prevention, control

  18. Residential radon and lung cancer incidence in a Danish cohort

    SciTech Connect (OSTI)

    Braeuner, Elvira V., E-mail: ole@cancer.dk [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Danish Building Research Institute, Aalborg University (Denmark); Andersen, Claus E. [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark)] [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark); Sorensen, Mette [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Jovanovic Andersen, Zorana [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark) [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Center for Epidemiology Screening, Department of Public Health, University of Copenhagen (Denmark); Gravesen, Peter [Geological Survey of Denmark and Greenland, Copenhagen (Denmark)] [Geological Survey of Denmark and Greenland, Copenhagen (Denmark); Ulbak, Kaare [National Institute of Radiation Protection, Herlev (Denmark)] [National Institute of Radiation Protection, Herlev (Denmark); Hertel, Ole [Department of Environmental Science, Aarhus University, Aarhus (Denmark)] [Department of Environmental Science, Aarhus University, Aarhus (Denmark); Pedersen, Camilla [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Overvad, Kim [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark)] [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark); Tjonneland, Anne; Raaschou-Nielsen, Ole [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)

    2012-10-15

    High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993-1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed. Median estimated radon was 35.8 Bq/m{sup 3}. The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69-1.56) in association with a 100 Bq/m{sup 3} higher radon concentration and 1.67 (95% CI: 0.69-4.04) among non-smokers. We found no evidence of effect modification. We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

  19. From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory

    SciTech Connect (OSTI)

    Martineau, Rebecca M

    2012-07-26

    In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

  20. Lifetime of high-k gate dielectrics and analogy with strength of quasibrittle Jia-Liang Le,1

    E-Print Network [OSTI]

    Bazant, Martin Z.

    for breakdown lifetime increases in proportion to the thickness of the oxide layer and suggests new ideas in the gate oxide layer induces the trap-assisted tunneling process, which leads to the gate leakage current

  1. Excited-Level Lifetimes and Hyperfine-Structure Measurements on Ions using Collinear Laser Ion-Beam Spectroscopy 

    E-Print Network [OSTI]

    Jin, J.; Church, David A.

    1994-01-01

    The mean lifetimes tau of the Ca II 4p P-2(1/2) and 4p P-2(3/2) levels, and the Cl-35 II 4p' F-1(3) level, have been measured by a variant of the collinear laser-ion-beam lifetime technique applied previously to the Ar II 4p' F-2(7/2)o level [Jian...

  2. Rangeland Risk Management for Texans: Types of Risk 

    E-Print Network [OSTI]

    White, Larry D.; Hanselka, C. Wayne

    2000-11-01

    Types of risk associated with range ecosystems include climatic, biological, financial and political risks. These risks are explained so that managers can know how to handle them....

  3. State Energy Risk Assessment Initiative - State Energy Risk Profiles...

    Energy Savers [EERE]

    Mission Energy Infrastructure Modeling and Analysis State Energy Risk Assessment Initiative - State Energy Risk Profiles State Energy Risk Assessment Initiative - State...

  4. risk management annual report

    E-Print Network [OSTI]

    Frantz, Kyle J.

    ____________________________________________________________________ 2 The ERM Process______________________________________________________________________ 28 The ERM Process in 2014 and Beyond and mitigating the risks that threaten its mission, the Office of Enterprise Risk Management (ERM) was tasked

  5. Finance and Risk & ENGINEERING

    E-Print Network [OSTI]

    Aronov, Boris

    Finance and Risk & ENGINEERING Charles S. Tapiero Department Head and Morton and Angela Topfer · Corporate Finance and Financial Markets · Computational Finance · Risk Finance · Technology and Algorithmic Finance A Collective Leadership Students participation #12;RESEARCH STRENGTHS · Black Swans and Fragility

  6. FIGHTING CANCER Cancer Research at the University of Notre Dame

    E-Print Network [OSTI]

    Buechler, Steven

    FIGHTING CANCER Cancer Research at the University of Notre Dame College of Science 168 Hurley Hall Fighting Cancer 5 Ani Aprahamian Isotopes for cancer therapy and immuno-diagnosis 7 Brian Baker Development of improved immunological therapies for cancer based on cellular immunity 9 Suzanne Bohlson Inflammation

  7. CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER SYNDROME (HBOC) ­ BRCA1 PATIENT INFORMATION What is Hereditary Breast and Ovarian Cancer syndrome? Hereditary Breast and Ovarian Cancer syndrome (HBOC) is the most common hereditary form of breast and ovarian cancer. About 2% of women

  8. THE BIOLOGICAL EFFECTS OF IONIZING RADIATION: EPIDEMIOLOGICAL SURVEYS AND LABORATORY ANIMAL EXPERIMENTS. IMPLICATIONS FOR RISK EVALUATION AND DECISION PROCESSES

    E-Print Network [OSTI]

    Fabrikant, J.I.

    2010-01-01

    human cancer risk from low radiation doses primarily frommodel for low-dose, low-LET radiation and carcinogenesis theis not observed at low radiation doses [ 1 9 ] . ships for

  9. Intrinsic state lifetimes in {sup 103}Pd and {sup 106,107}Cd

    SciTech Connect (OSTI)

    Ashley, S. F.; Thomas, N. J.; Regan, P. H.; Gelletly, W.; Andgren, K.; McCutchan, E. A.; Casten, R. F.; Plettner, C.; Vinson, J.; Werner, V.; Williams, E.; Zamfir, N. V.; Amon, L.; Cakirli, R. B.; Clark, R. M.; Guerdal, G.; Keyes, K. L.; Papenberg, A.; Meyer, D. A.; Erduran, M. N.

    2007-12-15

    The mean-lifetimes, {tau}, of various medium-spin excited states in {sup 103}Pd and {sup 106,107}Cd have been deduced using the Recoil Distance Doppler Shift technique and the Differential Decay Curve Method. In {sup 106}Cd, the mean-lifetimes of the I{sup {pi}}=12{sup +} state at E{sub x}=5418 keV and the I{sup {pi}}=11{sup -} state at E{sub x}=4324 keV have been deduced as 11.4(17)ps and 8.2(7)ps, respectively. The associated {beta}{sub 2} deformation within the axially-symmetric deformed rotor model for these states are 0.14(1) and 0.14(1), respectively. The {beta}{sub 2} deformation of 0.14(1) for the I{sup {pi}}=12{sup +} state in {sup 106}Cd compares with a predicted {beta}{sub 2} value from total Routhian surface (TRS) calculations of 0.17. In addition, the mean-lifetimes of the yrast I{sup {pi}}=(15/2){sup -} states in {sup 103}Pd (at E{sub x}=1262 keV) and {sup 107}Cd (at E{sub x}=1360 keV) have been deduced to be 31.2(44)ps and 31.4(17)ps, respectively, corresponding to {beta}{sub 2} values of 0.16(1) and 0.12(1) assuming axial symmetry. Agreement with TRS calculations are good for {sup 103}Pd but deviate for that predicted for {sup 107}Cd.

  10. Learning and risk aversion 

    E-Print Network [OSTI]

    Oyarzun, Carlos

    2009-06-02

    This dissertation contains three essays on learning and risk aversion. In the first essay we consider how learning may lead to risk averse behavior. A learning rule is said to be risk averse if it is expected to add more probability to an action...

  11. February 2002 RISK MANAGEMENT

    E-Print Network [OSTI]

    February 2002 RISK MANAGEMENT GUIDANCE FOR INFORMATION TECHNOLOGY SYSTEMS By Joan S. Hash, Computer is the ability to iden tify and protect critical information assets. A sound risk management pro gram-30, Risk Management Guide For Information Technology Systems, by Gary Stoneburner, Alice Goguen, and Alexis

  12. NISTIR 8023 Risk Management for

    E-Print Network [OSTI]

    with replication devices. Keywords 3D printers; 3D scanners; copiers; countermeasures; exploits; mitigation; multifunction devices; printers; replication devices; risk; risk assessment; risk management; scanners; security

  13. Sandia Energy - Probabilistic Risk Assessment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Probabilistic Risk Assessment Home Stationary Power Nuclear Fuel Cycle Nuclear Energy Safety Technologies Risk and Safety Assessment Probabilistic Risk Assessment Probabilistic...

  14. Sandia Energy - Security Risk Assessment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Security Risk Assessment Home Climate & Earth Systems WaterEnergy Nexus Water Monitoring & Treatment Technology Security Risk Assessment Security Risk Assessmentcwdd2015-05-04T21:...

  15. Data acquisition system for the MuLan muon lifetime experiment

    E-Print Network [OSTI]

    V. Tishchenko; S. Battu; S. Cheekatmalla; D. B. Chitwood; S. Dhamija; T. P. Gorringe; F. Gray; K. R. Lynch; I. Logashenko; S. Rath; D. M. Webber

    2008-02-07

    We describe the data acquisition system for the MuLan muon lifetime experiment at Paul Scherrer Institute. The system was designed to record muon decays at rates up to 1 MHz and acquire data at rates up to 60 MB/sec. The system employed a parallel network of dual-processor machines and repeating acquisition cycles of deadtime-free time segments in order to reach the design goals. The system incorporated a versatile scheme for control and diagnostics and a custom web interface for monitoring experimental conditions.

  16. Improved Measurement of the Positive Muon Lifetime and Determination of the Fermi Constant

    E-Print Network [OSTI]

    MuLan Collaboration; D. B. Chitwood; T. I. Banks; M. J. Barnes; S. Battu; R. M. Carey; S. Cheekatmalla; S. M. Clayton; J. Crnkovic; K. M. Crowe; P. T. Debevec; S. Dhamija; W. Earle; A. Gafarov; K. Giovanetti; T. P. Gorringe; F. E. Gray; M. Hance; D. W. Hertzog; M. F. Hare; P. Kammel; B. Kiburg; J. Kunkle; B. Lauss; I. Logashenko; K. R. Lynch; R. McNabb; J. P. Miller; F. Mulhauser; C. J. G. Onderwater; C. S. Ozben; Q. Peng; C. C. Polly; S. Rath; B. L. Roberts; V. Tishchenko; G. D. Wait; J. Wasserman; D. M. Webber; P. Winter; P. A. Zolnierczuk

    2008-02-08

    The mean life of the positive muon has been measured to a precision of 11 ppm using a low-energy, pulsed muon beam stopped in a ferromagnetic target, which was surrounded by a scintillator detector array. The result, tau_mu = 2.197013(24) us, is in excellent agreement with the previous world average. The new world average tau_mu = 2.197019(21) us determines the Fermi constant G_F = 1.166371(6) x 10^-5 GeV^-2 (5 ppm). Additionally, the precision measurement of the positive muon lifetime is needed to determine the nucleon pseudoscalar coupling g_P.

  17. Photo-degradation of Lexan polycarbonate studied using positron lifetime spectroscopy

    SciTech Connect (OSTI)

    Hareesh, K.; Sanjeev, Ganesh; Pandey, A. K.; Meghala, D.; Ranganathaiah, C.

    2013-02-05

    The free volume properties of pristine and UV irradiated Lexan polycarbonate have been investigated using Positron Lifetime Spectroscopy (PLS). The decrease in o-Ps life time and free volume size of irradiated sample is attributed to free volume modification and formation of more stable free radicals. These free radicals are formed due to the breakage of C-O bonds in Lexan polycarbonate after irradiation. This is also supported by the decrease in the intensity of C-O bond after exposure to UV-radiation as studied from Fourier Transform Infrared (FTIR) spectroscopy and it also shows that benzene ring does not undergo any changes after irradiation.

  18. Temperature dependence of diffusion length, lifetime and minority electron mobility in GaInP

    SciTech Connect (OSTI)

    Schultes, F. J.; Haegel, N. M.; Christian, T.; Alberi, K.; Fluegel, B.; Jones-Albertus, R.; Pickett, E.; Liu, T.; Misra, P.; Sukiasyan, A.; Yuen, H.

    2013-12-09

    The mobility of electrons in double heterostructures of p-type Ga{sub 0.50}In{sub 0.50}P has been determined by measuring minority carrier diffusion length and lifetime. The minority electron mobility increases monotonically from 300?K to 5?K, limited primarily by optical phonon and alloy scattering. Comparison to majority electron mobility over the same temperature range in comparably doped samples shows a significant reduction in ionized impurity scattering at lower temperatures, due to differences in interaction of repulsive versus attractive carriers with ionized dopant sites. These results should be useful in modeling and optimization for multi-junction solar cells and other optoelectronic devices.

  19. Backward air lasing actions induced by femtosecond laser filamentation: influence of population inversion lifetime

    E-Print Network [OSTI]

    Xie, Hongqiang; chu, Wei; Zeng, Bin; Yao, Jinping; Jing, Chenrui; Li, Ziting; Cheng, Ya

    2015-01-01

    We experimentally investigate generation of backward 357 nm N2 laser in a gas mixture of N2/Ar using 800-nm femtosecond laser pulses, and examine the involved gain dynamics based on pump-probe measurements. Our findings show that a minimum lifetime of population inversion in the excited N2 molecules is required for generating intense backward nitrogen lasers, which is ~0.8 ns under our experimental conditions. The results shed new light on the mechanism for generating intense backward lasers from ambient air, which are highly in demand for high sensitivity remote atmospheric sensing application.

  20. Addressing Inter-set Write-Variation for Improving Lifetime of Non-Volatile Caches

    SciTech Connect (OSTI)

    Mittal, Sparsh [ORNL] [ORNL; Vetter, Jeffrey S [ORNL] [ORNL

    2014-01-01

    We propose a technique which minimizes inter-set write variation in NVM caches for improving its lifetime. Our technique uses cache coloring scheme to add a software-controlled mapping layer between groups of physical pages (called memory regions) and cache sets. Periodically, the number of writes to different colors of the cache is computed and based on this result, the mapping of a few colors is changed to channel the write traffic to least utilized cache colors. This change helps to achieve wear-leveling.

  1. Development of time projection chamber for precise neutron lifetime measurement using pulsed cold neutron beams

    E-Print Network [OSTI]

    Y. Arimoto; N. Higashi; Y. Igarashi; Y. Iwashita; T. Ino; R. Katayama; R. Kitahara; M. Kitaguchi; H. Matsumura; K. Mishima; H. Oide; H. Otono; R. Sakakibara; T. Shima; H. M. Shimizu; T. Sugino; N. Sumi; H. Sumino; K. Taketani; G. Tanaka; M. Tanaka; K. Tauchi; A. Toyoda; T. Yamada; S. Yamashita; H. Yokoyama; T. Yoshioka

    2015-09-11

    A new time projection chamber (TPC) was developed for neutron lifetime measurement using a pulsed cold neutron spallation source at the Japan Proton Accelerator Research Complex (J-PARC). Managing considerable background events from natural sources and the beam radioactivity is a challenging aspect of this measurement. To overcome this problem, the developed TPC has unprecedented features such as the use of polyether-ether-ketone plates in the support structure and internal surfaces covered with $^6$Li-enriched tiles to absorb outlier neutrons. In this paper, the design and performance of the new TPC are reported in detail.

  2. Measurements of the masses, lifetimes and mixings of B hadrons at the Tevatron

    SciTech Connect (OSTI)

    Malde, S; /Oxford U.

    2009-09-01

    The Tevatron, with p{bar p} collisions at {radical}s = 1.96 TeV, can produce all flavors of B hadrons and allows for unprecedented studies in the B physics sector. The CDF and D0 collaborations have more than 5 fb{sup -1} of data recorded. I present here a selection of recent results on the masses, lifetimes and mixings of B hadrons using between 1.0 and 2.8 fb{sup -1} of data.

  3. Limits on the Higgs boson lifetime and width from its decay to four charged leptons

    E-Print Network [OSTI]

    Khachatryan, Vardan; Tumasyan, Armen; Adam, Wolfgang; A??lar, Ece; Bergauer, Thomas; Brandstetter, Johannes; Brondolin, Erica; Dragicevic, Marko; Erö, Janos; Flechl, Martin; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; Knünz, Valentin; König, Axel; Krammer, Manfred; Krätschmer, Ilse; Liko, Dietrich; Matsushita, Takashi; Mikulec, Ivan; Rabady, Dinyar; Rahbaran, Babak; Rohringer, Herbert; Schieck, Jochen; Schöfbeck, Robert; Strauss, Josef; Treberer-Treberspurg, Wolfgang; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Alderweireldt, Sara; Cornelis, Tom; De Wolf, Eddi A; Janssen, Xavier; Knutsson, Albert; Lauwers, Jasper; Luyckx, Sten; Ochesanu, Silvia; Rougny, Romain; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Abu Zeid, Shimaa; Blekman, Freya; D'Hondt, Jorgen; Daci, Nadir; De Bruyn, Isabelle; Deroover, Kevin; Heracleous, Natalie; Keaveney, James; Lowette, Steven; Moreels, Lieselotte; Olbrechts, Annik; Python, Quentin; Strom, Derek; Tavernier, Stefaan; Van Doninck, Walter; Van Mulders, Petra; Van Onsem, Gerrit Patrick; Van Parijs, Isis; Barria, Patrizia; Caillol, Cécile; Clerbaux, Barbara; De Lentdecker, Gilles; Delannoy, Hugo; Fasanella, Giuseppe; Favart, Laurent; Gay, Arnaud; Grebenyuk, Anastasia; Lenzi, Thomas; Léonard, Alexandre; Maerschalk, Thierry; Marinov, Andrey; Pernič, Luca; Randle-conde, Aidan; Reis, Thomas; Seva, Tomislav; Vander Velde, Catherine; Vanlaer, Pascal; Yonamine, Ryo; Zenoni, Florian; Zhang, Fengwangdong; Beernaert, Kelly; Benucci, Leonardo; Cimmino, Anna; Crucy, Shannon; Dobur, Didar; Fagot, Alexis; Garcia, Guillaume; Gul, Muhammad; Mccartin, Joseph; Ocampo Rios, Alberto Andres; Poyraz, Deniz; Ryckbosch, Dirk; Salva Diblen, Sinem; Sigamani, Michael; Strobbe, Nadja; Tytgat, Michael; Van Driessche, Ward; Yazgan, Efe; Zaganidis, Nicolas; Basegmez, Suzan; Beluffi, Camille; Bondu, Olivier; Brochet, Sébastien; Bruno, Giacomo; Castello, Roberto; Caudron, Adrien; Ceard, Ludivine; Da Silveira, Gustavo Gil; Delaere, Christophe; Favart, Denis; Forthomme, Laurent; Giammanco, Andrea; Hollar, Jonathan; Jafari, Abideh; Jez, Pavel; Komm, Matthias; Lemaitre, Vincent; Mertens, Alexandre; Nuttens, Claude; Perrini, Lucia; Pin, Arnaud; Piotrzkowski, Krzysztof; Popov, Andrey; Quertenmont, Loic; Selvaggi, Michele; Vidal Marono, Miguel; Beliy, Nikita; Hammad, Gregory Habib; Aldá Júnior, Walter Luiz; Alves, Gilvan; Brito, Lucas; Correa Martins Junior, Marcos; Hamer, Matthias; Hensel, Carsten; Mora Herrera, Clemencia; Moraes, Arthur; Pol, Maria Elena; Rebello Teles, Patricia; Belchior Batista Das Chagas, Ewerton; Carvalho, Wagner; Chinellato, Jose; Custódio, Analu; Da Costa, Eliza Melo; De Jesus Damiao, Dilson; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Huertas Guativa, Lina Milena; Malbouisson, Helena; Matos Figueiredo, Diego; Mundim, Luiz; Nogima, Helio; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Sznajder, Andre; Tonelli Manganote, Edmilson José; Vilela Pereira, Antonio; Ahuja, Sudha; Bernardes, Cesar Augusto; De Souza Santos, Angelo; Dogra, Sunil; Tomei, Thiago; De Moraes Gregores, Eduardo; Mercadante, Pedro G; Moon, Chang-Seong; Novaes, Sergio F; Padula, Sandra; Romero Abad, David; Ruiz Vargas, José Cupertino; Aleksandrov, Aleksandar; Genchev, Vladimir; Hadjiiska, Roumyana; Iaydjiev, Plamen; Piperov, Stefan; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Vutova, Mariana; Dimitrov, Anton; Glushkov, Ivan; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Ahmad, Muhammad; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Chen, Mingshui; Cheng, Tongguang; Du, Ran; Jiang, Chun-Hua; Plestina, Roko; Romeo, Francesco; Shaheen, Sarmad Masood; Tao, Junquan; Wang, Chunjie; Wang, Zheng; Zhang, Huaqiao; Asawatangtrakuldee, Chayanit; Ban, Yong; Li, Qiang; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Wang, Dayong; Xu, Zijun; Zou, Wei; Avila, Carlos; Cabrera, Andrés; Chaparro Sierra, Luisa Fernanda; Florez, Carlos; Gomez, Juan Pablo; Gomez Moreno, Bernardo; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Polic, Dunja; Puljak, Ivica; Ribeiro Cipriano, Pedro M; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Kadija, Kreso; Luetic, Jelena; Micanovic, Sasa; Sudic, Lucija; Attikis, Alexandros; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Rykaczewski, Hans; Bodlak, Martin; Finger, Miroslav; Finger Jr, Michael

    2015-01-01

    Constraints on the lifetime and width of the Higgs boson are obtained from $\\mathrm{H} \\to \\mathrm{ZZ} \\to 4\\ell$ events using data recorded by the CMS experiment during the LHC run 1 with an integrated luminosity of 5.1 and 19.7 fb$^{-1}$ at a center-of-mass energy of 7 and 8 TeV, respectively. The measurement of the Higgs boson lifetime is derived from its flight distance in the CMS detector with an upper bound of $\\tau_{\\mathrm{H}} $ lower than $ 1.9 \\times 10^{-13}$ s at the 95% confidence level (CL), corresponding to a lower bound on the width of $\\Gamma_{\\mathrm{H}} $ larger than $ 3.5 \\times 10^{-9} $ MeV. The measurement of the width is obtained from an off-shell production technique, generalized to include anomalous couplings of the Higgs boson to two electroweak bosons. From this measurement, a joint constraint is set on the Higgs boson width and a parameter $f_{\\Lambda Q}$ that expresses an anomalous coupling contribution as an on-shell cross-section fraction. The limit on the Higgs boson width is ...

  4. Lifetime measurements of normal deformed states in {sub 71}{sup 165}Lu

    SciTech Connect (OSTI)

    Andgren, K. [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom); Department of Physics, Royal Institute of Technology, Stockholm (Sweden); Podolyak, Zs.; Gelletly, W.; Walker, P. M.; Wheldon, C. [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom); Dewald, A.; Fitzler, A.; Moeller, O.; Pissulla, T. [Institut fuer Kernphysik, Universitaet zu Koeln, Zuelpicher Str. 77, D-50937 Cologne (Germany); Xu, F.R. [School of Physics, Peking University, Beijing (China); Algora, A. [IFIC, Valencia (Spain); MTA, ATOMKI, Debrecen (Hungary); Axiotis, M.; Angelis, G. de; Farnea, E.; Gadea, A.; Marginean, N.; Martinez, T.; Rusu, C. [I.N.F.N., Laboratori Nazionali di Legnaro, Legnaro (Italy); Bazzacco, D.; Lunardi, S. [Dipartimento di Fisica and I.N.F.N., Sezione di Padova, Padova (Italy)] [and others

    2005-01-01

    Picosecond lifetimes of medium spin states in {sup 165}Lu were measured for the first time. The reaction used to populate the nucleus of interest was {sup 139}La({sup 30}Si,4n){sup 165}Lu at a beam energy of 135 MeV. The beam was provided by the XTU-tandem accelerator of Laboratori Nazionali di Legnaro, Italy. By using the differential decay curve method, lifetimes of 19 states in four different rotational bands were obtained. Therefrom the B(E2) values and the transitional quadrupole moments were deduced. The obtained Q{sub t} for the different bands are compared with total Routhian surface (TRS) calculations and particle-rotor-model calculations. The TRS calculations predict different axial symmetric shapes for the bands built on the 9/2{sup -}[514], 9/2{sup +}[404], and 1/2{sup -}[541] configurations, with a {gamma} softness for the 9/2{sup -}[514] configuration. This band has also been studied using the particle-rotor model, the results of which, however, are consistent with a triaxial shape with a {gamma} value of -15 degrees.

  5. Recoil Distance Method Lifetime Measurements in 107Cd and 103Pd

    SciTech Connect (OSTI)

    Andgren, K.; Ashley, S. F.; Regan, P. H.; McCutchan, E. A.; Zamfir, N. V.; Casten, R. F.; Meyer, D. A.; Plettner, C.; Vinson, J.; Werner, V.; Williams, E.; Amon, L.; Cakirli, R. B.; Erduran, M. N.; Clark, R. M.; Guerdal, G.; Keyes, K. L.; Papenberg, A.; Pietralla, N.; Rainovski, G.

    2006-04-26

    Preliminary lifetime values have been measured for a number of near-yrast states in the odd-A transitional nuclei 107Cd and 103Pd. The reaction used to populate the nuclei of interest was 98Mo(12C,3nx{alpha})107Cd, 103Pd, with the beam delivered by the tandem accelerator of the Wright Nuclear Structure Laboratory at an incident beam energy of 60 MeV. Our experiment was aimed at the investigation of collective excitations built on the unnatural parity, {nu} h11/2 orbital, specifically by measuring the B(E2) values of decays from the excited levels built on this intrinsic structure, using the Doppler Recoil Distance Method. We report lifetimes and associated transition probabilities for decays from the 15/2- and the 19/2- states in 107Cd and the first measurement of the 15/2- state in 103Pd. These results suggest that neither a simple rotational or vibrational interpretation is sufficient to explain the observed structures.

  6. Limits on the Higgs boson lifetime and width from its decay to four charged leptons

    E-Print Network [OSTI]

    CMS Collaboration

    2015-07-23

    Constraints on the lifetime and width of the Higgs boson are obtained from H to ZZ to 4 lepton events using data recorded by the CMS experiment during the LHC run 1 with an integrated luminosity of 5.1 and 19.7 inverse femtobarns at a center-of-mass energy of 7 and 8 TeV, respectively. The measurement of the Higgs boson lifetime is derived from its flight distance in the CMS detector with an upper bound of tau[H] 3.5E-9 MeV. The measurement of the width is obtained from an off-shell production technique, generalized to include anomalous couplings of the Higgs boson to two electroweak bosons. From this measurement, a joint constraint is set on the Higgs boson width and a parameter f[LQ] that expresses an anomalous coupling contribution as an on-shell cross-section fraction. The limit on the Higgs boson width is Gamma[H] Higgs boson width.

  7. The wear-out approach for predicting the remaining lifetime of materials

    SciTech Connect (OSTI)

    GILLEN,KENNETH T.; CELINA,MATHIAS C.

    2000-05-11

    Failure models based on the Palmgren-Miner concept that material damage is cumulative have been derived and used mainly for fatigue life predictions for metals and composite materials. The authors review the principles underlying such models and suggest ways in which they may be best applied to polymeric materials in temperature environments. They first outline expectations when polymer degradation data can be rigorously time-temperature superposed over a given temperature range. For a step change in temperature after damage has occurred at an initial temperature in this range, the authors show that the remaining lifetime at the second temperature should be linearly related to the aging time prior to the step. This predicted linearity implies that it should be possible to estimate the remaining and therefore the service lifetime of polymers by completing the aging at an accelerated temperature. They refer to this generic temperature-step method as the Wear-out approach. They next outline the expectations for Wear-out experiments when time-temperature superposition is invalid. Experimental Wear-out results are then analyzed for one material where time-temperature superposition is valid and for another where evidence suggests it is invalid. In analyzing the data, they introduce a procedure that they refer to as time-degradation superposition. This procedure not only utilizes all of the experimental data instead of a single point from each data set, but also allows them to determine the importance of any interaction effects.

  8. Work at FNAL to achieve long electron drift lifetime in liquid argon

    SciTech Connect (OSTI)

    Finley, D.; Jaskierny, W.; Kendziora, C.; Krider, J.; Pordes, S.; Rapidis, P.A.; Tope, T.; /Fermilab

    2006-10-01

    This note records some of the work done between July 2005 and July 2006 to achieve long (many milliseconds) electron drift lifetimes in liquid argon at Fermilab. The work is part of a process to develop some experience at Fermilab with the technology required to construct a large liquid argon TPC. This technology has been largely developed by the ICARUS collaboration in Europe and this process can be seen as technology transfer. The capability to produce liquid argon in which electrons have drift lifetimes of several milliseconds is crucial to a successful device. Liquid argon calorimeters have been successfully operated at Fermilab; their electro-negative contaminants are at the level of 10{sup -7} while the TPC we are considering requires a contamination level at the level of 10{sup -11}, tens of parts per trillion (ppt). As well as demonstrating the ability to produce liquid argon at this level of purity, the work is part of a program to test the effect on the electron drift time of candidate materials for the construction of a TPC in liquid argon.

  9. Nonbreast Second Malignancies After Treatment of Primary Breast Cancer

    SciTech Connect (OSTI)

    Yadav, Budhi S. Sharma, Suresh C.; Patel, Firuza D.; Ghoshal, Sushmita; Kapoor, Rakesh; Kumar, Rajinder

    2009-04-01

    Purpose: To determine the incidence and risk factors for nonbreast second malignancies (NBSMs) in women after treatment for primary breast cancer. Methods and Materials: Between January 1985 and December 1995, a total of 1,084 breast cancer patients were analyzed for NBSMs. Detailed analysis was carried out for age, family history, disease stage, radiation therapy, chemotherapy, hormone therapy, other clinical/pathologic characteristics, and site of NBSMs. The Cox proportional hazard regression model was used to estimate the relative risk of NBSMs. Results: Median follow-up was 12 years. In total, 33 cases of NBSMs were noted in 29 patients. The overall incidence of NBSM was 3%, and the median time for NBSMs was 7 years. The most common NBSMs were gynecologic (22 patients), gastrointestinal (4 patients), head and neck (3 patients), hematologic (2 patients), lung (1 patient), and thyroid (1 patient). The NBSMs rate at 12 years was 2.4% for both mastectomy and radiation therapy groups. In the subset of patients less than 45 years of age at the time of treatment, the NBSMs rate was 0.7% as compared with 4.6% in patients more than 45 years of age (p = 0.001). Statistically significant higher incidences of endometrial and ovarian cancer were seen in patients with hormonal therapy (5.2%) as compared with patients without hormonal therapy (1.8%, p = 0.002). Women with a family history of breast cancer had a higher incidence (6%) of endometrial and ovarian malignancy compared with women without such a history (2.1%, p = 0.003). Chemotherapy did not affect the risk of second malignancy. Conclusion: The most common NBSMs in this study were gynecologic. Family history of breast cancer was a high risk factor for NBSMs. No risk of NBSMs with radiotherapy was observed.

  10. Risk Assessment Coherent Risks: An Axiomatic Approach Relation with Cooperative Game Concluding Remarks Risk, Coherency and Cooperative Game

    E-Print Network [OSTI]

    Li, Haijun

    Risk Assessment Coherent Risks: An Axiomatic Approach Relation with Cooperative Game Concluding 2011 1 / 30 #12;Risk Assessment Coherent Risks: An Axiomatic Approach Relation with Cooperative Game Concluding Remarks Outline 1 Risk Assessment Risk = Volatility? Modern Portfolio Theory (MPT) Risk

  11. Nested methylation-specific polymerase chain reaction cancer detection method

    DOE Patents [OSTI]

    Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

    2007-05-08

    A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

  12. Cancer Due to Prolonged Inflammation

    E-Print Network [OSTI]

    Lingampalli, Nithya

    2013-01-01

    Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

  13. Bismuth 213 Cancer Treatment

    ScienceCinema (OSTI)

    None

    2013-05-28

    See how INL scientists are increasing supplies of radioactive medical isotopes to treat cancer. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  14. Sample-Specific Cancer Pathway Analysis Using PARADIGM

    E-Print Network [OSTI]

    Benz, Stephen Charles

    2012-01-01

    associated with Ovarian Cancer 29 3.2.3 Di?erentiallyOvarian Cancer . . . . . . . . . . . . . . . . . . . . . .Ovarian Cancer) . . . . . . . . . . . . . . . . . . . . . .

  15. Detailed Report of the MuLan Measurement of the Positive Muon Lifetime and Determination of the Fermi Constant

    E-Print Network [OSTI]

    V. Tishchenko; S. Battu; R. M. Carey; D. B. Chitwood; J. Crnkovic; P. T. Debevec; S. Dhamija; W. Earle; A. Gafarov; K. Giovanetti; T. P. Gorringe; F. E. Gray; Z. Hartwig; D. W. Hertzog; B. Johnson; P. Kammel; B. Kiburg; S. Kizilgul; J. Kunkle; B. Lauss; I. Logashenko; K. R. Lynch; R. McNabb; J. P. Miller; F. Mulhauser; C. J. G. Onderwater; Q. Peng; J. Phillips; S. Rath; B. L. Roberts; D. M. Webber; P. Winter; B. Wolfe

    2012-11-05

    We present a detailed report of the method, setup, analysis and results of a precision measurement of the positive muon lifetime. The experiment was conducted at the Paul Scherrer Institute using a time-structured, nearly 100%-polarized, surface muon beam and a segmented, fast-timing, plastic scintillator array. The measurement employed two target arrangements; a magnetized ferromagnetic target with a ~4 kG internal magnetic field and a crystal quartz target in a 130 G external magnetic field. Approximately 1.6 x 10^{12} positrons were accumulated and together the data yield a muon lifetime of tau_{mu}(MuLan) = 2196980.3(2.2) ps (1.0 ppm), thirty times more precise than previous generations of lifetime experiments. The lifetime measurement yields the most accurate value of the Fermi constant G_F (MuLan) = 1.1663787(6) x 10^{-5} GeV^{-2} (0.5 ppm). It also enables new precision studies of weak interactions via lifetime measurements of muonic atoms.

  16. Correlation lifetimes of quiet and magnetic granulation from the SOUP (Solar Optical Universal Polarimeter) instrument on Spacelab 2

    SciTech Connect (OSTI)

    Title, A.; Tarbell, T.; Topka, K.; Acton, L.; Duncan, D.

    1988-10-01

    The flight of the Solar Optical Universal Polarimeter (SOUP) on Spacelab 2 allowed the collection of time sequences of diffraction-limited (0.5 arc second) granulation images with excellent pointing (0.003 arc second jitter RMS) and freedom from the distortion that plagues ground-based images. The solar 5 minute oscillations are clearly seen in the data. Using Fourier transforms in the temporal and spatial domain, the authors show that these dominate the autocorrelation lifetime in magnetic regions. When the oscillations are removed the autocorrelation lifetime is found to be 410 and 890 seconds, respectively, in quiet and magnetic regions. In quiet areas exploding granules are common. It is hard to find that neither explodes nor is unaffected by a nearby explosion. A significant fraction of granule lifetimes are terminated by nearby explosions. Local correlation-tracking techniques are used to measure horizontal displacements, and thus transverse velocities, in the intensity field. In the quiet sun it is possible to detect both super- and mesogranulation. Horizontal velocities are as great as 1000 m/s quiet sun, and the average velocity is 400 m/s. In magnetic regions, horizontal velocities are much less, about 200 m/s. These flows effect the measured lifetime. A lower limit to the lifetime in quiet and magnetic sun is estimated to be 440 and 950 seconds respectively.

  17. Risk Policy and Risk Management Procedures The University's Risk Policy sets out The University's approach to risk and its

    E-Print Network [OSTI]

    Aickelin, Uwe

    Risk Policy and Risk Management Procedures Preface The University's Risk Policy sets out The University's approach to risk and its management together with the means for identifying, analysing and managing risk in order to minimise its frequency and impact. The risks considered significant

  18. Professional Certificate in Risk Management

    E-Print Network [OSTI]

    Carleton University

    Professional Certificate in Risk Management 2010 Program 3 Part-time Courses CRM01: Essentials of Risk Management ­ Next Session Fall 2010 CRM02: Risk Control ­ Jan. 12 - April 26, 2010 CRM03: Risk to apply for the Canadian Risk Management (CRM) designation. #12;Professional Certificate in Risk

  19. HOUNSFIELD REVIEW SERIES Cancer risks from diagnostic radiology

    E-Print Network [OSTI]

    Brenner, David Jonathan

    the ``As Low As Reasonably Achievable'' (ALARA) principle and, as we discuss, opportunities do exist

  20. Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk

    E-Print Network [OSTI]

    2009-01-01

    Tob. Control 14, 396-404. Schick, S. , Glantz, S.A. 2006.J Epidemiol. 130, 213-220. Schick, S. , Glantz, S.A. 2005.four times more toxic (Schick and Glantz, 2005). Moreover,

  1. Talking About Breast Density and Cancer Risk | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    by a complicated relationship between ethnic, hereditary, environmental (diet, geography), reproductive (age at first pregnancy, number of children) and hormonal factors....

  2. Sociocultural definitions of risk

    SciTech Connect (OSTI)

    Rayner, S.

    1990-10-01

    Public constituencies frequently are criticized by technical experts as being irrational in response to low-probability risks. This presentation argued that most people are concerned with a variety of risk attributes other than probability and that is rather irrational to exclude these from the definition and analysis of technological risk. Risk communication, which is at the heart of the right-to-know concept, is described as the creation of shared meaning rather than the mere transmission of information. A case study of utilities, public utility commissions, and public interest groups illustrates how the diversity of institutional cultures in modern society leads to problems for the creation of shared meanings in establishing trust, distributing liability, and obtaining consent to risk. This holistic approach to risk analysis is most appropriate under conditions of high uncertainty and/or decision stakes. 1 fig., 5 tabs.

  3. Measurement of the Positive Muon Lifetime and Determination of the Fermi Constant to Part-per-Million Precision

    E-Print Network [OSTI]

    D. M. Webber; V. Tishchenko; Q. ~Peng; S. Battu; R. M. Carey; D. B. Chitwood; J. Crnkovic; P. T. Debevec; S. Dhamija; W. Earle; A. Gafarov; K. Giovanetti; T. P. Gorringe; F. E. Gray; Z. Hartwig; D. W. Hertzog; B. Johnson; P. Kammel; B. Kiburg; S. Kizilgul; J. Kunkle; B. Lauss; I. Logashenko; K. R. Lynch; R. McNabb; J. P. Miller; F. Mulhauser; C. J. G. Onderwater; J. Phillips; S. Rath; B. L. Roberts; P. Winter; B. Wolfe

    2010-12-06

    We report a measurement of the positive muon lifetime to a precision of 1.0 parts per million (ppm); it is the most precise particle lifetime ever measured. The experiment used a time-structured, low-energy muon beam and a segmented plastic scintillator array to record more than 2 x 10^{12} decays. Two different stopping target configurations were employed in independent data-taking periods. The combined results give tau_{mu^+}(MuLan) = 2196980.3(2.2) ps, more than 15 times as precise as any previous experiment. The muon lifetime gives the most precise value for the Fermi constant: G_F(MuLan) = 1.1663788 (7) x 10^-5 GeV^-2 (0.6 ppm). It is also used to extract the mu^-p singlet capture rate, which determines the proton's weak induced pseudoscalar coupling g_P.

  4. Collision lifetimes of polyatomic molecules at low temperatures: Benzene–benzene vs benzene–rare gas atom collisions

    SciTech Connect (OSTI)

    Cui, Jie; Krems, Roman V.; Li, Zhiying

    2014-10-28

    We use classical trajectory calculations to study the effects of the interaction strength and the geometry of rigid polyatomic molecules on the formation of long-lived collision complexes at low collision energies. We first compare the results of the calculations for collisions of benzene molecules with rare gas atoms He, Ne, Ar, Kr, and Xe. The comparison illustrates that the mean lifetimes of the collision complexes increase monotonically with the strength of the atom–molecule interaction. We then compare the results of the atom–benzene calculations with those for benzene–benzene collisions. The comparison illustrates that the mean lifetimes of the benzene–benzene collision complexes are significantly reduced due to non-ergodic effects prohibiting the molecules from sampling the entire configuration space. We find that the thermally averaged lifetimes of the benzene–benzene collisions are much shorter than those for Xe with benzene and similar to those for Ne with benzene.

  5. Use of groundwater lifetime expectancy for the performance assessment of a deep geologic waste repository: 1. Theory, illustrations, and implications

    E-Print Network [OSTI]

    Cornaton, F J; Normani, S D; Sudicky, E A; Sykes, J F

    2011-01-01

    Long-term solutions for the disposal of toxic wastes usually involve isolation of the wastes in a deep subsurface geologic environment. In the case of spent nuclear fuel, if radionuclide leakage occurs from the engineered barrier, the geological medium represents the ultimate barrier that is relied upon to ensure safety. Consequently, an evaluation of radionuclide travel times from a repository to the biosphere is critically important in a performance assessment analysis. In this study, we develop a travel time framework based on the concept of groundwater lifetime expectancy as a safety indicator. Lifetime expectancy characterizes the time that radionuclides will spend in the subsurface after their release from the repository and prior to discharging into the biosphere. The probability density function of lifetime expectancy is computed throughout the host rock by solving the backward-in-time solute transport adjoint equation subject to a properly posed set of boundary conditions. It can then be used to defi...

  6. Inflammation & Inflammation & cancer

    E-Print Network [OSTI]

    Beimel, Amos

    Tam & tnf dc cytokines metastasis metabolism #12;22 chemokine gradient in cancer (Balkwill et al. 2004 1861) Wound healing dc Tam & tnf cytokines metastasis therapeutics metabolism inflammation The end #12 & tnf cytokines metastasis metabolism #12;4 Motivation Cancer as an overhealing wound Lets Go! Wound

  7. Enhancement of minority carrier lifetime of GaInP with lateral composition modulation structure grown by molecular beam epitaxy

    SciTech Connect (OSTI)

    Park, K. W.; Ravindran, Sooraj; Kang, S. J.; Hwang, H. Y.; Jho, Y. D.; Park, C. Y.; Jo, Y. R.; Kim, B. J.; Lee, Y. T.

    2014-07-28

    We report the enhancement of the minority carrier lifetime of GaInP with a lateral composition modulated (LCM) structure grown using molecular beam epitaxy (MBE). The structural and optical properties of the grown samples are studied by transmission electron microscopy and photoluminescence, which reveal the formation of vertically aligned bright and dark slabs corresponding to Ga-rich and In-rich GaInP regions, respectively, with good crystal quality. With the decrease of V/III ratio during LCM GaInP growth, it is seen that the band gap of LCM GaInP is reduced, while the PL intensity remains high and is comparable to that of bulk GaInP. We also investigate the minority carrier lifetime of LCM structures made with different flux ratios. It is found that the minority carrier lifetime of LCM GaInP is ?37 times larger than that of bulk GaInP material, due to the spatial separation of electrons and holes by In-rich and Ga-rich regions of the LCM GaInP, respectively. We further demonstrate that the minority carrier lifetime of the grown LCM GaInP structures can easily be tuned by simply adjusting the V/III flux ratio during MBE growth, providing a simple yet powerful technique to tailor the electrical and optical properties at will. The exceptionally high carrier lifetime and the reduced band gap of LCM GaInP make them a highly attractive candidate for forming the top cell of multi-junction solar cells and can enhance their efficiency, and also make them suitable for other optoelectronics devices, such as photodetectors, where longer carrier lifetime is beneficial.

  8. Study of behavior and determination of customer lifetime value(CLV) using Markov chain model

    SciTech Connect (OSTI)

    Permana, Dony, E-mail: donypermana@students.itb.ac.id [Statistics Research Division, Faculty of Mathematics and Natural Science, Bandung Institute of Technology, Indonesia and Statistics Study Program, Faculty of Mathematics and Natural Sciences, Padang State University (Indonesia); Indratno, Sapto Wahyu; Pasaribu, Udjianna S. [Statistics Research Division, Faculty of Mathematics and Natural Science, Bandung Institute of Technology (Indonesia)

    2014-03-24

    Customer Lifetime Value or CLV is a restriction on interactive marketing to help a company in arranging financial for the marketing of new customer acquisition and customer retention. Additionally CLV can be able to segment customers for financial arrangements. Stochastic models for the fairly new CLV used a Markov chain. In this model customer retention probability and new customer acquisition probability play an important role. This model is originally introduced by Pfeifer and Carraway in 2000 [1]. They introduced several CLV models, one of them only involves customer and former customer. In this paper we expand the model by adding the assumption of the transition from former customer to customer. In the proposed model, the CLV value is higher than the CLV value obtained by Pfeifer and Caraway model. But our model still requires a longer convergence time.

  9. Monte Carlo simulation of the experiment MAMBO I and possible correction of neutron lifetime result

    E-Print Network [OSTI]

    A. P. Serebrov; A. K. Fomin

    2009-04-14

    We are discussing the present situation with neutron lifetime measurements. There is a serious discrepancy between the previous experiments and the recent precise experiment [1]. The possible reason of the discrepancy can be connected with a quasi-elastic scattering of UCN on the surface of liquid fomblin which was used for most of the previous experiments. The Monte Carlo simulation of one of the previous experiments [2] shows that the result of this experiment [2] has to be corrected and instead of the previous result 887.6 +/- 3 s the new result 880.4 +/- 3 s has to be claimed. [1] A.P. Serebrov et al., Phys. Lett. B 605 (2005) 72. [2] W. Mampe et al., Phys. Rev. Lett. 63 (1989) 593.

  10. Constraints on neutrino decay lifetime using long-baseline charged and neutral current data

    E-Print Network [OSTI]

    R. A. Gomes; A. L. G. Gomes; O. L. G. Peres

    2014-12-11

    We investigate the status of a scenario involving oscillations and decay for charged and neutral current data from the MINOS and T2K experiments. We first present an analysis of charged current neutrino and anti-neutrino data from MINOS in the framework of oscillation with decay and obtain a best fit for non-zero decay parameter $\\alpha_3$. The MINOS charged and neutral current data analysis results in the best fit for $|\\Delta m_{32}^2| = 2.34\\times 10^{-3}$~eV$^2$, $\\sin^2 \\theta_{23} = 0.60$ and zero decay parameter, which corresponds to the limit for standard oscillations. Our combined MINOS and T2K analysis reports a constraint at the 90\\% confidence level for the neutrino decay lifetime $\\tau_3/m_3 > 2.8 \\times 10^{-12}$~s/eV. This is the best limit based only on accelerator produced neutrinos.

  11. Stochastic Boundary, Diffusion, Emittance Growth and Lifetime calculation for the RHIC e-lens

    SciTech Connect (OSTI)

    Abreu,N.P.; Fischer, W.; Luo, Y.; Robert-Demolaize, G.

    2009-01-20

    To compensate the large tune shift and tune spread generated by the head-on beam-beam interactions in polarized proton operation in the Relativistic Heavy Ion Collider (RHIC), a low energy electron beam with proper Gaussian transverse profiles was proposed to collide head-on with the proton beam. In this article, using a modified version of SixTrack [1], we investigate stability of the single particle in the presence of head-on beam-beam compensation. The Lyapunov exponent and action diffusion are calculated and compared between the cases without and with beam-beam compensation for two different working points and various bunch intensities. Using the action diffusion results the emittance growth rate and lifetime of the proton beam is also estimated for the different scenarios.

  12. Lifetime improvement of sheathed thermocouples for use in high-temperature and thermal transient operations

    SciTech Connect (OSTI)

    McCulloch, R.W.; Clift, J.H.

    1982-01-01

    Premature failure of small-diameter, magnesium-oxide-insulated sheathed thermocouples occurred when they were placed within nuclear fuel rod simulators (FRSs) to measure high temperatures and to follow severe thermal transients encountered during simulation of nuclear reactor accidents in Oak Ridge National Laboratory (ORNL) thermal-hydraulic test facilities. Investigation of thermally cycled thermocouples yielded three criteria for improvement of thermocouple lifetime: (1) reduction of oxygen impurities prior to and during their fabrication, (2) refinement of thermoelement grain size during their fabrication, and (3) elimination of prestrain prior to use above their recrystallization temperature. The first and third criteria were satisfied by improved techniques of thermocouple assembly and by a recovery anneal prior to thermocouple use.

  13. Combined results on b-hadron production rates, lifetimes, oscillations and semileptonic decays

    SciTech Connect (OSTI)

    WIllocq, stephane

    2000-08-02

    Combined results on b-hadron lifetimes, b-hadron production rates B{sub d}{sup 0}--Anti-B{sub d}{sup 0} and B{sub s}{sup 0}--Anti-B{sub s}{sup 0} oscillations, the decay width difference between the mass eigenstates of the B{sub s}{sup 0}--Anti-B{sub s}{sup 0} system, and the values of the CKM matrix elements {vert_bar}V{sub cb}{vert_bar} and {vert_bar}V{sub ub}{vert_bar} are obtained from published and preliminary measurements available in Summer 99 from the ALEPH, CDF, DELPHI, L3, OPAL and SLD Collaborations.

  14. Cancer Cell Survival of Cancer Cells Is Maintained

    E-Print Network [OSTI]

    Leps, Jan "Suspa"

    Cancer Cell Article Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase,* and Mien-Chie Hung2,* 1Department of Cancer Biology 2Department of Molecular and Cellular Oncology The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA 3Present

  15. Mathematics for Cancer Research making optimal use of cancer data

    E-Print Network [OSTI]

    Coolen, ACC "Ton"

    Mathematics for Cancer Research making optimal use of cancer data ACC Coolen King's College London ACC Coolen (KCL) Mathematics in cancer research January 2015 1 / 63 #12;1 Quality of raw data Bayesian projects ... ACC Coolen (KCL) Mathematics in cancer research January 2015 2 / 63 #12;biomedical research

  16. CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER SYNDROME (HBOC) ­ BRCA2 PATIENT INFORMATION What is Hereditary Breast and Ovarian Cancer syndrome? People with BRCA2 alterations have a genetic condition called Hereditary Breast and Ovarian Cancer syndrome (HBOC). HBOC is caused by an error

  17. Evaluation of Lifetime of High Efficiency Organic Photovoltaic Devices: Cooperative Research and Development Final Report, CRADA Number CRD-10-379

    SciTech Connect (OSTI)

    Olson, D.

    2013-04-01

    As a part of this joint work, Solarmer and NREL will investigate the lifetime and stability of Organic Photovoltaic Devices based on Solarmer high efficiency active layer materials.

  18. Progress on Establishing Guidelines for National Ignition Facility (NIF) Experiments to Extend Debris Shield Lifetime

    SciTech Connect (OSTI)

    Tobin, M; Eder, D; Braun, D; MacGowan, B

    2000-07-26

    The survivability and performance of the debris shields on the National Ignition Facility (NIF) are a key factor for the successful conduct and affordable operation of the facility. The improvements required over Nova debris shields are described. Estimates of debris shield lifetimes in the presence of target emissions with 4 - 5 J/cm{sup 2} laser fluences (and higher) indicate lifetimes that may contribute unacceptably to operations costs for NIF. We are developing detailed guidance for target and experiment designers for NIF to assist in minimizing the damage to, and therefore the cost of, maintaining NIF debris shields. The guidance limits the target mass that is allowed to become particulate on the debris shields (300 mg). It also limits the amount of material that can become shrapnel for any given shot (10 mg). Finally, it restricts the introduction of non-volatile residue (NVR) that is a threat to the sol-gel coatings on the debris shields to ensure that the chamber loading at any time is less than 1 pg/cm{sup 2}. We review the experimentation on the Nova chamber that included measuring quantities of particulate on debris shields by element and capturing shrapnel pieces in aerogel samples mounted in the chamber. We also describe computations of x-ray emissions from a likely NIF target and the associated ablation expected from this x-ray exposure on supporting target hardware. We describe progress in assessing the benefits of a pre-shield and the possible impact on the guidance for target experiments on NIF. Plans for possible experimentation on Omega and other facilities to improve our understanding of target emissions and their impacts are discussed. Our discussion of planned future work provides a forum to invite possible collaboration with the IFE community.

  19. Risk assessment for osteoporotic fractures among men and women from a prospective population study: the EPIC-Norfolk study

    E-Print Network [OSTI]

    Moayyeri, Alireza

    2012-03-06

    . In this thesis, I aimed to evaluate novel risk factors for osteoporosis and develop a fracture risk assessment model among the middle-aged and older people. I used data from the European Prospective Investigation into Cancer (EPIC)-Norfolk study, which is a large...

  20. Receipt of Guideline-Concordant Treatment in Elderly Prostate Cancer Patients

    SciTech Connect (OSTI)

    Chen, Ronald C., E-mail: Ronald_chen@med.unc.edu [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Carpenter, William R. [Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Hendrix, Laura H. [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Bainbridge, John [Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Wang, Andrew Z. [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Nielsen, Matthew E. [Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); and others

    2014-02-01

    Purpose: To examine the proportion of elderly prostate cancer patients receiving guideline-concordant treatment, using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. Methods and Materials: A total of 29,001 men diagnosed in 2004-2007 with localized prostate cancer, aged 66 to 79 years, were included. We characterized the proportion of men who received treatment concordant with the National Comprehensive Cancer Network guidelines, stratified by risk group and age. Logistic regression was used to examine covariates associated with receipt of guideline-concordant management. Results: Guideline concordance was 79%-89% for patients with low- or intermediate-risk disease. Among high-risk patients, 66.6% of those aged 66-69 years received guideline-concordant management, compared with 51.9% of those aged 75-79 years. Discordance was mainly due to conservative management—no treatment or hormone therapy alone. Among the subgroup of patients aged ?76 years with no measured comorbidity, findings were similar. On multivariable analysis, older age (75-79 vs 66-69 years, odds ratio 0.51, 95% confidence interval 0.50-0.57) was associated with a lower likelihood of guideline concordance for high-risk prostate cancer, but comorbidity was not. Conclusions: There is undertreatment of elderly but healthy patients with high-risk prostate cancer, the most aggressive form of this disease.

  1. Page 1 of 2 Risk Management March 2012 Risk Management

    E-Print Network [OSTI]

    Page 1 of 2 Risk Management March 2012 Risk Management Supervisor's Vehicle Incident Report (Complete all sections of this form and return within 24 hours of incident to the Office of Risk Management Risk Management March 2012 Risk Management Unsafe Conditions or Actions (describe all contributing

  2. OPERATIONAL RISK RODNEY COLEMAN

    E-Print Network [OSTI]

    Coleman, Rodney

    the business environment. These include terrorism, civil unrest, systems fail- ings including hacking RISKS ARISING FROM BUSINESS ACTIVITY You lose business opportunities while your computer systems a business beyond those from its money-making activities. This is operational risk, often shortened to oprisk

  3. RISK ASSESSMENT CLOUD COMPUTING

    E-Print Network [OSTI]

    Columbia University

    SECURITY RESEARCH PRIVACY RISK ASSESSMENT AMC DATA FISMA CLOUD COMPUTING MOBILE DEVICES OPERATIONS PRACTICES TRENDS AUDITS policies #12;2 Privacy & Information Security Annual Update Thursday, June 20, 2013 of Breach statistics Plan to comply with requirements · Training and Education Information Security · Risk

  4. Recognizing liability risks

    SciTech Connect (OSTI)

    Price, C.; Zimmer, M.J.; Karas, J.L. (Reid Priest, Washington, DC (United States))

    1993-09-01

    Project developers, owners, investors, and lenders face potential liability for environmental contamination and cleanup. Being aware of the risks is the first step in mitigating future concerns. Independent power participants are wise to be concerned with a range of risks arising from off- or on-site contamination, civil and criminal violations of rules and regulations, and future compliance costs.

  5. Digital Tomosynthesis: Advanced Breast Cancer

    E-Print Network [OSTI]

    Hansma, Paul

    Digital Tomosynthesis: Advanced Breast Cancer Imaging Technique Max Wiedmann #12;Digital in CT. #12;Breast Cancer · The leading Cause of death for women ages 40-55. · Is only behind lung and bronchus cancer in terms of number of deaths in US. · Early detection of breast cancer is believed to save

  6. Survivorship Clinic Nutrition after Cancer

    E-Print Network [OSTI]

    Brent, Roger

    Survivorship Clinic Nutrition after Cancer Surviving cancer has a way of changing the way you look of practical, everyday questions that accompany life as a cancer survivor: Now what? How should I live successful treatment and are now leading vital, cancer- free lives. Maybe your doctor or dietitian has

  7. QUESTIONS & ANSWERS ABOUT LUNG CANCER

    E-Print Network [OSTI]

    QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

  8. Familial site-specific Ovarian cancer is linked to BRCA1 on 17q12-21

    SciTech Connect (OSTI)

    Steichen-Gersdorf, E.; Gallion, H.H.; Ponder, M.A.; Pye, C.; Mazoyer, S.; Smith, S.A.; Ponder, B.A.J.; Ford, D.; Easton, D.F.; Girodet, C.

    1994-11-01

    In a study of nine families with {open_quotes}site-specific{close_quotes} ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age <50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32-1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46-1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive. 17 refs., 3 figs., 1 tab.

  9. Molecular Markers of Lung Cancer in MAYAK Workers

    SciTech Connect (OSTI)

    Steven A. Belinsky, PhD

    2007-02-15

    The molecular mechanisms that result in the elevated risk for lung cancer associated with exposure to radiation have not been well characterized. Workers from the MAYAK nuclear enterprise are an ideal cohort in which to study the molecular epidemiology of cancer associated with radiation exposure and to identify the genes targeted for inactivation that in turn affect individual risk for radiation-induced lung cancer. Epidemiology studies of the MAYAK cohort indicate a significantly higher frequency for adenocarcinoma and squamous cell carcinoma (SCC) in workers than in a control population and a strong correlation between these tumor types and plutonium exposure. Two hypotheses will be evaluated through the proposed studies. First, radiation exposure targets specific genes for inactivation by promoter methylation. This hypothesis is supported by our recent studies with the MAYAK population that demonstrated the targeting of the p16 gene for inactivation by promoter methylation in adenocarcinomas from workers (1). Second, genes inactivated in tumors can serve as biomarkers for lung cancer risk in a cancer-free population of workers exposed to plutonium. Support for this hypothesis is based on exciting preliminary results of our nested, case-control study of persons from the Colorado cohort. In that study, a panel of methylation markers for predicting lung cancer risk is being evaluated in sputum samples from incident lung cancer cases and controls. The first hypothesis will be tested by determining the prevalence for promoter hypermethylation of a panel of genes shown to play a critical role in the development of either adenocarcinoma and/or SCC associated with tobacco. Our initial studies on adenocarcinoma in MAYAK workers will be extended to evaluate methylation of the PAX5 {alpha}, PAX5 {beta}, H-cadherin, GATA5, and bone morphogenesis 3B (BMP3B) genes in the original sample set described under Preliminary studies. In addition, studies will be initiated in SCC from workers and controls to identify genes targeted for inactivation by plutonium in this other common histologic form of lung cancer. We will examine methylation of the p16, O{sup 6}-methylguanine-DNA methyl-transferase (MGMT), and death associated protein kinase genes ([DAP-K], evaluated previously in adenocarcinomas) as well as the new genes being assessed in the adenocarcinomas. The second hypothesis will be tested in a cross-sectional study of cancer-free workers exposed to plutonium and an unexposed population. A cohort of 700 cancer-free workers and 700 unexposed persons is being assembled, exposures are being defined, and induced sputum collected at initial entry into the study and approximately 1-year later. Exposed and unexposed persons will be matched by 5-year age intervals and smoking status (current and former). The frequency for methylation of four genes that show the greatest difference in prevalence in tumors from workers and controls will be determined in exfoliated cells within sputum. These studies will extend those in primary tumors to determine whether difference in prevalence for individual or multiple genes are detected in sputum samples from high-risk subjects exposed to plutonium. Follow-up of this cohort offers the opportunity to validate these endpoints and future biomarkers as true markers for lung cancer risk.

  10. Modeling toxic endpoints for improving human health risk assessment 

    E-Print Network [OSTI]

    Bruce, Erica Dawn

    2009-05-15

    RAGS Risk Assessment Guidance For Superfund RCRA Resource Conservation and Recovery Act SD Sum of Squared Deviation TCDD 2,3,7,8-Tetrachlorodibenzo-p-Dioxin TEF Toxic Equivalency Factor TEF B Bioassay Based Toxic Equivalency... Amendments (HSWA) of 1984 further strengthened the EPA?s ability to regulate waste disposal. The HSWA was responsible for the eventual removal of land disposal of hazardous wastes. Cancers, renal disease, circulatory disorders, reproductive disorders...

  11. Prediction of the Creep-Fatigue Lifetime of Alloy 617: An Application of Non-destructive Evaluation and Information Integration

    SciTech Connect (OSTI)

    Vivek Agarwal; Richard Wright; Timothy Roney

    2014-08-01

    A relatively simple method using the nominal constant average stress information and the creep rupture model is developed to predict the creep-fatigue lifetime of Alloy 617, in terms of time to rupture. The nominal constant average stress is computed using the stress relaxation curve. The predicted time to rupture can be converted to number of cycles to failure using the strain range, the strain rate during each cycle, and the hold time information. The predicted creep-fatigue lifetime is validated against the experimental measurements of the creep-fatigue lifetime collected using conventional laboratory creep-fatigue tests. High temperature creep-fatigue tests of Alloy 617 were conducted in air at 950°C with a tensile hold period of up to 1800s in a cycle at total strain ranges of 0.3% and 0.6%. It was observed that the proposed method is conservative in that the predicted lifetime is less than the experimentally determined values. The approach would be relevant to calculate the remaining useful life to a component like a steam generator that might fail by the creep-fatigue mechanism.

  12. Doping dependence of the carrier lifetime crossover point upon dissociation of iron-boron pairs in crystalline silicon

    E-Print Network [OSTI]

    in crystalline silicon D. Macdonald, T. Roth, P. N. K. Deenapanray, T. Trupke, and R. A. Bardos Citation: Applied in crystalline silicon by temperature- and injection-level-dependent lifetime measurements J. Appl. Phys. 97 crossover point upon dissociation of iron-boron pairs in crystalline silicon D. Macdonald,a T. Roth,b and P

  13. Evolution and lifetimes of flow topology in a turbulent boundary layer G. E. Elsinga and I. Marusic

    E-Print Network [OSTI]

    Marusic, Ivan

    Evolution and lifetimes of flow topology in a turbulent boundary layer G. E. Elsinga and I. Marusic of Physics. Related Articles Lagrangian evolution of the invariants of the velocity gradient tensor subject to AIP license or copyright; see http://pof.aip.org/about/rights_and_permissions #12;Evolution

  14. Improving the lifetime performance of ceramic fuel cells Fuel cells generate electricity from fuels more efficiently and with

    E-Print Network [OSTI]

    Rollins, Andrew M.

    2014 Improving the lifetime performance of ceramic fuel cells Fuel cells generate electricity from fuels more efficiently and with fewer emissions per watt than burning fossil fuels. But as fuel cells received an $800,000 Department of Energy grant to study how to make one type of fuel cell--solid oxide

  15. Fluorescence Lifetimes and Emission Patterns Probe the 3D Orientation of the Emitting Chromophore in a Multichromophoric System

    E-Print Network [OSTI]

    Enderlein, Jörg

    Fluorescence Lifetimes and Emission Patterns Probe the 3D Orientation of the Emitting Chromophore the orientation of the absorption transition dipole)15,16 and wide-field defocusing (probing the emission. It was suggested that, at any moment in time, the emission of a single dendrimer originates from the chromophore

  16. Hydrogen Bond Lifetimes and Energetics for Solute/Solvent Complexes Studied with 2D-IR Vibrational Echo Spectroscopy

    E-Print Network [OSTI]

    Fayer, Michael D.

    Hydrogen Bond Lifetimes and Energetics for Solute/Solvent Complexes Studied with 2D-IR Vibrational@stanford.edu Abstract: Weak hydrogen-bonded solute/solvent complexes are studied with ultrafast two the dissociation and formation rates of the hydrogen-bonded complexes. The dissociation rates of the weak hydrogen

  17. Accelerating Solutions of Perfect Fluid Hydrodynamics for Initial Energy Density and Life-Time Measurements in Heavy Ion Collisions

    E-Print Network [OSTI]

    T. Csorgo; M. I. Nagy; M. Csanad

    2007-04-17

    A new class of accelerating, exact, explicit and simple solutions of relativistic hydrodynamics is presented. Since these new solutions yield a finite rapidity distribution, they lead to an advanced estimate of the initial energy density and life-time of high energy heavy ion reactions. Accelerating solutions are also given for spherical expansions in arbitrary number of spatial dimensions.

  18. MAXIMIZING THE LIFETIME OF CLUSTERS WITH SLEPIAN-WOLF CODING Tianqi Wang, Wendi Heinzelman, Alireza Seyedi, and Azadeh Vosoughi

    E-Print Network [OSTI]

    Heinzelman, Wendi

    is not energy constrained. When the fusion center is energy constrained, a near optimum solution is provided coding of data sent to a fusion center. Exact closed form solutions are derived when the fusion center-- Distributed source coding, Wireless sensor networks, Energy efficiency, Lifetime I. INTRODUCTION In general

  19. Magnetic dipole transition rates from measured lifetimes of levels of Be-like and B-like argon ions 

    E-Print Network [OSTI]

    Moehs, D. P.; Church, David A.

    1998-01-01

    The lifetimes of the 1s(2)2s2p P-3(2) level of Ar XV and 1s(2)2s(2)2p P-2(3/2) of Ar XIV have been measured using metastable Ar14+ and Ar13+ ions produced by an electron cyclotron resonance ion source, which were subsequently separately captured...

  20. Dependence of nuclear spin singlet lifetimes on RF spin-locking power Stephen J. DeVience a,

    E-Print Network [OSTI]

    Rosen, Matthew S

    Dependence of nuclear spin singlet lifetimes on RF spin-locking power Stephen J. DeVience a: Received 6 January 2012 Revised 14 March 2012 Available online 28 March 2012 Keywords: Nuclear singlet of long-lived nuclear spin singlet states as a function of the strength of the RF spin-locking field

  1. Measurements and calculations of metastable level lifetimes in Fe X, Fe XI, Fe XII, Fe XIII, and Fe XIV 

    E-Print Network [OSTI]

    Moehs, D. P.; Bhatti, M. I.; Church, David A.

    2001-01-01

    Lifetimes of metastable levels in the ground term of Fe ions within the 3s(2)3p(k), k=1-5, isoelectronic sequences have been measured. These measurements were performed utilizing ions that were selected by mass to charge ratio while transported from...

  2. Measurement of the [bar over B][0 over s] Meson Lifetime in D[+ over s]?[superscript ?] Decays

    E-Print Network [OSTI]

    Aaij, R.

    We present a measurement of the ratio of the [bar over B][0 over s] meson lifetime, in the flavor-specific decay to D[+ over s]?[superscript ?], to that of the [bar over B][superscript 0] meson. The pp collision data used ...

  3. 1834 IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS, VOL. 22, NO. 11, NOVEMBER 2011 Analysis of Link Lifetimes and Neighbor

    E-Print Network [OSTI]

    Yao, Zhongmei

    , Senior Member, IEEE Abstract--Several models of user churn, resilience, and link lifetime have recently restricted to the successor of the failed zone in the DHT space. To understand neighbor churn Churn. ! 1 INTRODUCTION RESILIENCE of distributed peer-to-peer (P2P) networks under user churn has

  4. Influence of local-field effects on the radiative lifetime of liquid suspensions of Nd:YAG

    E-Print Network [OSTI]

    Boyd, Robert W.

    Influence of local-field effects on the radiative lifetime of liquid suspensions of Nd Received July 24, 2006; revised September 29, 2006; accepted October 13, 2006; posted October 25, 2006 (Doc information regarding local-field effects, we fitted the ex- perimental data to three different local

  5. Targeting mTOR in Pancreatic Cancer

    E-Print Network [OSTI]

    Soares, Heloisa Prado

    2015-01-01

    Parsons J, Kern SE. Progression model for pancreatic cancer.Clinical Cancer Research. 2000;6(N8):2969-72.Martinelli P. Pancreatic Cancer Development and Progression:

  6. Model Risk in Finance Department of Statistics

    E-Print Network [OSTI]

    Stine, Robert A.

    worth taking Statistical issues Multiplicity Transformations to obtain "independence" Orthogonality Year Valueof$100Investment Case-Shiller Housing Total Stock Market 3 #12;Wharton default Correlation risk Regulatory risk Reputation risk Operational risk Systemic risk, market risk

  7. Written Informed Consent for Computed Tomography of the Abdomen/Pelvis is Associated with Decreased CT Utilization in Low-Risk Emergency Department Patients

    E-Print Network [OSTI]

    Merck, Lisa H.; Ward, Laura A.; Applegate, Kimberly E.; Choo, Esther; Lowery-North, Douglas W.; Heilpern, Katherine L.

    2015-01-01

    of cancer from low-dose radiation. Pediatr and neutrons.Eur Urol. Low Doses of Ionizing Radiation: Assessing What WeLand CE. Low-Dose Extrapolation of Radiation Health Risks:

  8. Systemic risk in consumer finance

    E-Print Network [OSTI]

    Poon, Martha

    2011-01-01

    Systemic risk in consumer finance Uncertain about risk HowComplexity, Ecology, Finance The Pre-History of ResilienceSystemic risk in consumer finance Martha Poon, NYU At the

  9. Risk in the Weapons Stockpile

    SciTech Connect (OSTI)

    Noone, Bailey C

    2012-08-14

    When it comes to the nuclear weapons stockpile, risk must be as low as possible. Design and care to keep the stockpile healthy involves all aspects of risk management. Design diversity is a method that helps to mitigate risk.

  10. Risk Management in Biopharmaceutical Supply Chains

    E-Print Network [OSTI]

    Ma, Yao

    2011-01-01

    Supply Chain Risk Managementof Recent Work on Supply Chain Risk Management . . . . .M. , Supply chain risk management: Outlining an agenda for

  11. Extending the Lifetime of a Network of Battery-Powered Mobile Devices by Remote Processing: A Markovian Decision-based Approach

    E-Print Network [OSTI]

    Pedram, Massoud

    Extending the Lifetime of a Network of Battery-Powered Mobile Devices by Remote Processing the lifetime of a battery- powered mobile host in a client-server wireless network by using task migration-line adaptive policy is proposed, which dynamically monitors the channel conditions and the server behavior

  12. Modifications of the exciton lifetime and internal quantum efficiency for organic light-emitting devices with a weak/strong microcavity

    E-Print Network [OSTI]

    Wai, Ping-kong Alexander

    to their applications in display and lighting.1­4 Considering the microcavity effect, OLEDs can be roughly categorizedModifications of the exciton lifetime and internal quantum efficiency for organic light on the modifications of the exciton lifetime and internal quantum efficiency int for organic light-emitting devices

  13. Aneuploidy: Cancer's Fatal Flaw?

    E-Print Network [OSTI]

    Williams, Bret R.

    Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we ...

  14. Eye Cancer- Cobalt Treatment 

    E-Print Network [OSTI]

    Unknown

    2011-08-17

    Ductal carcinoma in situ (DCIS) has been shown to be a precursor to invasive ductal cancer (IDC). Though the progression of DCIS to IDC is believed to be an important aspect of tumor aggressiveness, prognosis and molecular markers that predict...

  15. Targeting Breast Cancer Metastasis

    E-Print Network [OSTI]

    Mu, Ping

    Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30–40% of patients may eventually suffer from distant relapse and ...

  16. A Reanalysis of Curvature in the Dose Response for Cancer and Modifications by Age at Exposure Following Radiation Therapy for Benign Disease

    SciTech Connect (OSTI)

    Little, Mark P.; Stovall, Marilyn; Smith, Susan A.; Kleinerman, Ruth A.

    2013-02-01

    Purpose: To assess the shape of the dose response for various cancer endpoints and modifiers by age and time. Methods and Materials: Reanalysis of the US peptic ulcer data testing for heterogeneity of radiogenic risk by cancer endpoint (stomach, pancreas, lung, leukemia, all other). Results: There are statistically significant (P<.05) excess risks for all cancer and for lung cancer and borderline statistically significant risks for stomach cancer (P=.07), and leukemia (P=.06), with excess relative risks Gy{sup -1} of 0.024 (95% confidence interval [CI] 0.011, 0.039), 0.559 (95% CI 0.221, 1.021), 0.042 (95% CI -0.002, 0.119), and 1.087 (95% CI -0.018, 4.925), respectively. There is statistically significant (P=.007) excess risk of pancreatic cancer when adjusted for dose-response curvature. General downward curvature is apparent in the dose response, statistically significant (P<.05) for all cancers, pancreatic cancer, and all other cancers (ie, other than stomach, pancreas, lung, leukemia). There are indications of reduction in relative risk with increasing age at exposure (for all cancers, pancreatic cancer), but no evidence for quadratic variations in relative risk with age at exposure. If a linear-exponential dose response is used, there is no significant heterogeneity in the dose response among the 5 endpoints considered or in the speed of variation of relative risk with age at exposure. The risks are generally consistent with those observed in the Japanese atomic bomb survivors and in groups of nuclear workers. Conclusions: There are excess risks for various malignancies in this data set. Generally there is a marked downward curvature in the dose response and significant reduction in relative risk with increasing age at exposure. The consistency of risks with those observed in the Japanese atomic bomb survivors and in groups of nuclear workers implies that there may be little sparing effect of fractionation of dose or low-dose-rate exposure.

  17. Risk Management Process Overview | Department of Energy

    Energy Savers [EERE]

    Risk Management Process Overview Risk Management Process Overview figure depicting three tier risk management process The cybersecurity risk management process explained in the...

  18. Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer

    E-Print Network [OSTI]

    Weber, David J.

    Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program ­ Genetic Epidemiology of Cancer Associate Professor Tenuretrack Health is expanding research in Cancer Genetic Epidemiology to enrich an already robust campuswide

  19. Global Asteroid Risk Analysis

    E-Print Network [OSTI]

    Rumpf, Clemens

    2014-01-01

    Potentially impacting asteroids were analysed for their impact risk on the Earth. To this end, the Asteroid Risk Mitigation Optimization and Research (ARMOR) tool is currently being developed. The tool's modules are described and their validation is documented. Based on the asteroid ephemeris, the tool calculates the impact location probability distribution on the surface of the Earth (in the literature, occasionally referred to as risk corridor). NASA's Near Earth Object (NEO) risk list served as the source for asteroid ephemerides. The Line of Variation (LOV) method was employed to find virtual impactors. While offering a simple and fast way of identifying virtual impactors, the method provides a low impactor identification rate. This is because the search space is tightly constricted to the LOV and thus excludes virtual impactors located elsewhere in the asteroid position uncertainty region. The method's performance was evaluated and suggestions for improvements are provided. Application of the tool showed...

  20. Risk Management Guide

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-01-18

    This Guide provides non-mandatory risk management approaches for implementing the requirements of DOE O 413.3B, Program and Project Management for the Acquisition of Capital Assets. Supersedes DOE G 413.3-7.