National Library of Energy BETA

Sample records for lcf latent cancer

  1. Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis

    E-Print Network [OSTI]

    Gerry, Arianna Aldridge

    2011-01-01

    1998). Reducing cervical cancer among First Nations women.K. , & Edwards, B.K. (2002). Cancer survival among US whitestreatment of primary breast cancer: A systematic review.

  2. Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis

    E-Print Network [OSTI]

    Gerry, Arianna Aldridge

    2011-01-01

    treatment of primary breast cancer: A systematic review.Perceived risk of breast cancer among women at average and2003). Nutrition and breast cancer. Breast, 12, 412-416.

  3. Latent effects decision analysis

    DOE Patents [OSTI]

    Cooper, J. Arlin (Albuquerque, NM); Werner, Paul W. (Albuquerque, NM)

    2004-08-24

    Latent effects on a system are broken down into components ranging from those far removed in time from the system under study (latent) to those which closely effect changes in the system. Each component is provided with weighted inputs either by a user or from outputs of other components. A non-linear mathematical process known as `soft aggregation` is performed on the inputs to each component to provide information relating to the component. This information is combined in decreasing order of latency to the system to provide a quantifiable measure of an attribute of a system (e.g., safety) or to test hypotheses (e.g., for forensic deduction or decisions about various system design options).

  4. ARM - Measurement - Latent heat flux

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Comments?govInstrumentsnoaacrnBarrow, Alaska Outreach Home Roomparticle sizefractiongovMeasurementsLatent heat

  5. Assessment of Latent Heat Reservoirs for Thermal Management of...

    Office of Scientific and Technical Information (OSTI)

    Assessment of Latent Heat Reservoirs for Thermal Management of QCW Laser Diodes Citation Details In-Document Search Title: Assessment of Latent Heat Reservoirs for Thermal...

  6. A Feedback Paradigm for Latent Fingerprint Matching

    E-Print Network [OSTI]

    suspects · Improving latent fingerprint matching accuracy is one of the major goals of FBI's NGI program FBI's IAFIS.* *http://www.fbi.gov/news/stories /2011/october/print_101411 2 #12;Motivation · NIST Fp

  7. Latent class analysis of new self-report measures of physical and sexual abuse

    E-Print Network [OSTI]

    Nooner, Kate Brody

    2007-01-01

    Collins, L.M. (2003). Latent class and latent transitionSTATE UNIVERSITY Latent Class Analysis of New Self-ReportFigure 6 Class 1 of Combined

  8. Patterns of neighborhood environment attributes related to physical activity across 11 countries: a latent class analysis

    E-Print Network [OSTI]

    2013-01-01

    built environment: a latent class analysis approach. Health37. Collins LM, Lanza ST: Latent Class and Latent Transition11 countries: a latent class analysis Marc A Adams 1* , Ding

  9. Latent Class Analysis of Antisocial Behavior: Interaction of Serotonin Transporter Genotype and Maltreatment

    E-Print Network [OSTI]

    Li, James J.; Lee, Steve S.

    2010-01-01

    fit testing for latent class models. Multivariate BehavioralFerdinand, R. F. (2007). Classes of disruptive behaviorVermunt, J. K. (2004). Latent class models. In D. Kaplan (

  10. A Topography-Preserving Latent Variable Model with Learning Metrics

    E-Print Network [OSTI]

    Kaski, Samuel

    A Topography-Preserving Latent Variable Model with Learning Metrics Samuel Kaski and Janne grid to the input spa- ce. The mapping preserves the topography but measures local distances in terms

  11. Experimental Evaluation of Latent Variable Models for Dimensionality Reduction

    E-Print Network [OSTI]

    Carreira-Perpinan, Miguel A; Renals, Steve

    1998-01-01

    We use electropalatographic (EPG) data as a test bed for dimensionality reduction methods based in latent variable modelling, in which an underlying lower dimension representation is inferred directly from the data. Several ...

  12. Project Profile: Heat Transfer and Latent Heat Storage in Inorganic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    energy storage capacity of a thermocline. The PCM-based TES uses the latent heat of fusion of inorganic salt mixtures for storing thermal energy. The concepts being applied by...

  13. A latent-variable modelling approach to the acoustic-to-articulatory mapping problem. I

    E-Print Network [OSTI]

    Carreira-Perpinan, Miguel A; Renals, Steve

    1999-01-01

    We present a latent variable approach to the acoustic-to-articulatory mapping problem, where different vocal tract configurations can give rise to the same acoustics. In latent variable modelling, the combined acoustic and ...

  14. Analysis of a graphite foam-NaCl latent heat storage system for...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Analysis of a graphite foam-NaCl latent heat storage system for supercritical CO2 power cycles for concentrated solar power Title Analysis of a graphite foam-NaCl latent heat...

  15. Latent-Descriptor Clustering for Unsupervised POS Induction Michael Lamar

    E-Print Network [OSTI]

    Bienenstock, Elie

    Latent-Descriptor Clustering for Unsupervised POS Induction Michael Lamar Department of Mathematics unsupervised, POS tagging, based on an adaptation of the EM algorithm for the esti- mation of a Gaussian evaluation criteria for unsupervised POS tagging, LDC shows a substantial im- provement in performance over

  16. T THE FOURTH TRMM LATENT HEATING WORKSHOP WHAT: Scientists from Japan and the United States

    E-Print Network [OSTI]

    Houze Jr., Robert A.

    T THE FOURTH TRMM LATENT HEATING WORKSHOP WHAT: Scientists from Japan and the United States shared with the associated latent heat (LH) release accounting for three-fourths of the total heat energy available to Earth for improving cloud parameterizations in environmental predic- tion models. The Fourth TRMM Latent Heating

  17. Switched Dynamical Latent Force Models for Modelling Transcriptional Regulation

    E-Print Network [OSTI]

    Lpez-Lopera, Andrs F

    2015-01-01

    In order to develop statistical approaches for transcription networks, statistical community has proposed several methods to infer activity levels of proteins, from time-series measurements of targets' expression levels. A few number of approaches have been proposed in order to outperform the representation of fast switching time instants, but computational overheads are significant due to complex inference algorithms. Using the theory related to latent force models (LFM), the development of this project provide a switched dynamical hybrid model based on Gaussian processes (GPs). To deal with discontinuities in dynamical systems (or latent driving force), an extension of the single input motif approach is introduced, that switches between different protein concentrations, and different dynamical systems. This creates a versatile representation for transcription networks that can capture discrete changes and non-linearities in the dynamics. The proposed method is evaluated on both simulated data and real data,...

  18. Bayesian latent variable modelling in studies of air pollution and health

    E-Print Network [OSTI]

    Scheichl, Robert

    Bayesian latent variable modelling in studies of air pollution and health Duncan Lee, Gavin://www.bath.ac.uk/math-sci/BICS #12;Bayesian latent variable modelling in studies of air pollution and health. Duncan Lee (1), Gavin to air pollution on respiratory mortality in the elderly (aged 65 and above) in London, England, between

  19. Identifying the Membrane Proteome of HIV-1 Latently Infected Cells*S

    E-Print Network [OSTI]

    Vertes, Akos

    Identifying the Membrane Proteome of HIV-1 Latently Infected Cells*S Received for publication, **Department of Biochemistry/ Center for Sickle Cell Disease, Howard University, Washington, D. C. 20059 of established human immunodeficiency virus-1 (HIV-1) latent cell models and parental cell lines. To this end we

  20. Considering latent attitudes in mode choice: The case of Switzerland Hurtubia, Atasoy, Glerum, Curchod and Bierlaire

    E-Print Network [OSTI]

    Bierlaire, Michel

    Considering latent attitudes in mode choice: The case of Switzerland Hurtubia, Atasoy, Glerum, Curchod and Bierlaire Considering latent attitudes in mode choice: The case of Switzerland Ricardo, Switzerland, ricardo.hurtubia@epfl.ch Bilge Atasoy, Transport and Mobility Laboratory, Ecole Polytechnique F

  1. Selection of latent variables for multiple mixed-outcome LING ZHOU, HUAZHEN LIN

    E-Print Network [OSTI]

    Li, Yi

    Survey, a global research project that explores peoples' values and beliefs and the social and personal outcomes, latent variables represent theoretical concepts or constructs that cannot be directly assessed's statistical properties. We propose a new penalized pseudo-likelihood method that selects latent variables

  2. Clustering South African Households Based on their Asset Status Using Latent Variable Models.

    E-Print Network [OSTI]

    Washington at Seattle, University of

    Clustering South African Households Based on their Asset Status Using Latent Variable Models into homogeneous groups based on their asset status. A model-based approach to clustering, based on latent variable and the models are combined to produce a hybrid model capable of handling mixed data types. Further, a mixture

  3. Liu UCD Phy9B 07 12 17-6. Phase Change: Latent Heat

    E-Print Network [OSTI]

    Yoo, S. J. Ben

    Liu UCD Phy9B 07 12 17-6. Phase Change: Latent Heat GasLiquidSolid onVaporizatiFusion Phase of fusion LF Absorbs leasesRe Solid Liquid Absorbs leasesRe Liquid Gas heat of vaporization LV Latent in fluids: liquids & gases. Forced convection: circulation by pump/blower Natural convection: natural

  4. An investigation into the thermal properties of selected sensible and latent heat storage materials

    E-Print Network [OSTI]

    Wood, Stanley Clayton

    1982-01-01

    in the latent heat of fusion. Considerable work has been done in analyzing latent heat storage systems. Telkes and Raymond [lj did early work with a sodium sulfate system using sealed drums. iVore recent experimental work was conducted with other salt...

  5. Formation of nanometer-size wires using infiltration into latent nuclear tracks

    DOE Patents [OSTI]

    Musket, Ronald G. (Danville, CA); Felter, Thomas E. (Livermore, CA)

    2002-01-01

    Nanometer-size wires having a cross-sectional dimension of less than 8 nm with controllable lengths and diameters are produced by infiltrating latent nuclear or ion tracks formed in trackable materials with atomic species. The trackable materials and atomic species are essentially insoluble in each other, thus the wires are formed by thermally driven, self-assembly of the atomic species during annealing, or re-crystallization, of the damage in the latent tracks. Unlike conventional ion track lithography, the inventive method does not require etching of the latent tracks.

  6. Latent class analysis of new self-report measures of physical and sexual abuse

    E-Print Network [OSTI]

    Nooner, Kate Brody

    2007-01-01

    Latent class analysis (LCA) will be used to meet this goalLanza, Flaherty & Collins, 2003). LCA capitalizes on the3) physical and sexual abuse. LCA will be used to identify

  7. Multiple memory systems and extinction: the neurobiological basis of latent extinction

    E-Print Network [OSTI]

    Gabriele, Amanda

    2009-05-15

    to be impaired following hippocampal inactivation and the goal of Aim 1 was to examine other neural systems potentially involved in latent extinction through examination of brain structures such as the dorsal striatum, medial prefrontal cortex, and basolateral...

  8. Project Profile: Hybrid Organic Silicone HTF Utilizing Endothermic Chemical Reactions for Latent Heat Storage

    Broader source: Energy.gov [DOE]

    Los Alamos National Laboratory, under an ARRA CSP Award, is developing a thermally stable, working heat transfer fluid (HTF) that is integrated with chemical reactions as a methodology to store large amounts of latent heat.

  9. Quantification of latent travel demand on new urban facilities in the state of Texas

    E-Print Network [OSTI]

    Henk, Russell H

    1989-01-01

    , becomes obvious that there is a need for a more accurate procedure in the identification of this commonly occurring phenomenon known as latent travel demand. The SDHPT is responsible for evaluating and prioritizing alternative highway projects...QUANTIFICATION OF LATENT TRAVEL DEMAND ON NEW URBAN FACILITIES IN THE STATE OF TEXAS A Thesis by RUSSELL HAROLD HENK Submitted to the Office of Graduate Studies of Texas ASM University in partial fulfillment of the requirements...

  10. Global patterns of landatmosphere fluxes of carbon dioxide, latent heat, and sensible heat derived from eddy covariance,

    E-Print Network [OSTI]

    Chen, Jiquan

    Global patterns of landatmosphere fluxes of carbon dioxide, latent heat, and sensible heat derived 2011. [1] We upscaled FLUXNET observations of carbon dioxide, water, and energy fluxes to the global (NEE), latent energy (LE), and sensible heat (H) based on remote sensing indices, climate

  11. Clustering Educational Digital Library Usage Data: A Comparison of Latent Class Analysis and

    E-Print Network [OSTI]

    Qi, Xiaojun

    Clustering Educational Digital Library Usage Data: A Comparison of Latent Class Analysis and K an educational digital library service, the Instructional Architect (IA.usu.edu). Using a multi-faceted approach Class Analysis, K-means, Digital Libraries, Teacher Users

  12. Segmentation and Enhancement of Latent Fingerprints: A Coarse to Fine Ridge

    E-Print Network [OSTI]

    ., "Image Quality Assessment: From Error Visibility to Structural Similarity", IEEE Transaction on ImageSegmentation and Enhancement of Latent Fingerprints: A Coarse to Fine Ridge Structure Dictionary ridge Pores Include all dimensional attributes of the ridge such as pores, edge contour, incipient

  13. Efficient Energy Management and Data Recovery in Sensor Networks using Latent Variables Based Tensor

    E-Print Network [OSTI]

    Simunic, Tajana

    Efficient Energy Management and Data Recovery in Sensor Networks using Latent Variables Based factor in a successful sensor network deployment is finding a good balance between maximizing the number of measurements taken (to maintain a good sampling rate) and minimizing the overall energy consumption (to extend

  14. The immunology of Human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?

    E-Print Network [OSTI]

    Wills, M. R.; Poole, Emma; Lau, Betty; Krishna, Ben; Sinclair, John

    2014-08-18

    employed during latent infection. US28 is a G-protein coupled receptor that can bind both CC (eg CCL5, MCP-1, MCP-3, MIP1-?, and MIP1-?) and Cx3C (eg fractalkine) chemokines. The ability of US28 to bind multiple cytokines and cause their internalization...

  15. Determination of solid fractiontemperature relation and latent heat using full scale

    E-Print Network [OSTI]

    Beckermann, Christoph

    Determination of solid fractiontemperature relation and latent heat using full scale casting* Casting simulation results are only useful to a foundry if they reflect reality, which requires accurate of commonly used metal alloys for which no reliable material data are available. The present study focuses

  16. A Dynamic Model for Induced Reactivation of Latent Virus G.M. Kepler1,5

    E-Print Network [OSTI]

    that inducing agents such as Tetradecanoyl Phorbol Acetate (TPA), sodium butyrate, and other short chain fatty is applied to the reactivation of latent KSHV in BCBL-1 cell cultures with butyrate as the inducing agent acids (SFAs) can induce lytic replication of Kaposi's Sarcoma-associated Herpes virus (KSHV) and Epstein

  17. AEROSOL-CLOUD INTERACTIONS CONTROL OF EARTH RADIATION AND LATENT HEAT RELEASE BUDGETS

    E-Print Network [OSTI]

    Daniel, Rosenfeld

    AEROSOL-CLOUD INTERACTIONS CONTROL OF EARTH RADIATION AND LATENT HEAT RELEASE BUDGETS D. ROSENFELD simulations show that cloud development is strongly mod- ulated by the impact of cloud-aerosol interactions on precipitation forming processes. New insights into the mechanisms by which aerosols dominate the cloud cover

  18. Second neoplasms following radiotherapy or chemotherapy for cancer

    SciTech Connect (OSTI)

    Penn, I.

    1982-02-01

    While radiotherapy and antineoplastic chemotherapy often control malignancies they may, paradoxically, cause new cancers to develop as long-term complications. Although almost any type of neoplasm can occur, radiation-induced malignancies are most likely to affect the myelopoietic tissues and the thyroid gland. The former tissues are also most frequently involved by chemotherapy. The combination of intensive radiotherapy and intensive chemotherapy is particularly leukemogenic. Acute myeloid leukemia has occurred with increased frequency following treatment of Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, ovarian cancer, polycythemia vera, carcinoma of the thyroid gland, and carcinoma of the breast. Radiation-induced malignancies usually occur in the field of irradiation. Tumors developing in an irradiated field include a substantial number of soft tissue sarcomas or osteosarcomas. There is a 20-fold increase of second cancers following treatment of childhood malignancies, mostly sarcomas of bone and soft tissues, but including leukemia, and carcinomas of the thyroid gland, skin, and breast. The latent period between radiotherapy and the appearance of a second cancer ranges from 2 years to several decades, often being 10-15 years. With chemotherapy the mean latent period is shorter, approximately 4 years. The mechanism of oncogenesis by radiotherapy or chemotherapy is poorly understood and probably involves a complex interplay of somatic mutation, co-oncogenic effects, depression of host immunity, stimulation of cellular proliferation, and genetic susceptibility.

  19. The Sensitivity of Latent Heat Flux to Changes in the Radiative Forcing: A Framework for Comparing Models and Observations

    E-Print Network [OSTI]

    Eltahir, Elfatih A. B.

    A climate model must include an accurate surface physics scheme in order to examine the interactions between the land and atmosphere. Given an increase in the surface radiative forcing, the sensitivity of latent heat flux ...

  20. Assessment and Prediction of the Thermal Performance of a Centralized Latent Heat Thermal Energy Storage Utilizing Artificial Neural Network

    E-Print Network [OSTI]

    El-Sawi, A.; Haghighat, F.; Akbari, H.

    2013-01-01

    A simulation tool is developed to analyze the thermal performance of a centralized latent heat thermal energy storage system (LHTES) using computational fluid dynamics (CFD). The LHTES system is integrated with a mechanical ventilation system...

  1. Stochastic volatility models with persistent latent factors: theory and its applications to asset prices

    E-Print Network [OSTI]

    Lee, Hyoung Il

    2008-10-10

    filter. See, e.g., Tanizaki (1996) for a general introduction to the density-based Kalman fil- ter. The second approach applies the standard Bayesian procedure and estimates the unknown parameters and latent factor by their posterior means, which... transition and persistent la- tent factors. We argue that this model has advantages over theconventional stochastic model for the persistent volatility factor. Though the linear filtering is widely used in the state space model, the simulation result, as well...

  2. SU(3) Latent Heat and Surface Tension from Tree Level and Tadpole Improved Actions

    E-Print Network [OSTI]

    Beinlich, B; Peikert, A

    1996-01-01

    We analyze the latent heat and surface tension at the SU(3) deconfinement phase transition with tree level and tadpole improved Symanzik actions on lattices with temporal extent $N_\\tau = 3$ and 4 and spatial extent $N_\\sigma/ N_\\tau = 4$, 6 and 8. In comparison to the standard Wilson action we do find a drastic reduction of cut-off effects already with tree level improved actions. On lattices with temporal extent $N_\\tau=4$ results for the surface tension and latent heat obtained with a tree level improved action agree well with those obtained with a tadpole improved action. A comparison with $N_\\tau=3$ calculations, however, shows that results obtained with tadpole action remain unaffected by cut-off effects even on this coarse lattice, while the tree level action becomes sensitive to the cut-off. For the surface tension and latent heat we find $\\sigma_I/ T_c^3 = 0.0155~(16)$ and $\\Delta\\epsilon/T_c^4 = 1.40~(9)$, respectively.

  3. SU(3) Latent Heat and Surface Tension from Tree Level and Tadpole Improved Actions

    E-Print Network [OSTI]

    B. Beinlich; F. Karsch; A. Peikert

    1996-08-27

    We analyze the latent heat and surface tension at the SU(3) deconfinement phase transition with tree level and tadpole improved Symanzik actions on lattices with temporal extent $N_\\tau = 3$ and 4 and spatial extent $N_\\sigma/ N_\\tau = 4$, 6 and 8. In comparison to the standard Wilson action we do find a drastic reduction of cut-off effects already with tree level improved actions. On lattices with temporal extent $N_\\tau=4$ results for the surface tension and latent heat obtained with a tree level improved action agree well with those obtained with a tadpole improved action. A comparison with $N_\\tau=3$ calculations, however, shows that results obtained with tadpole action remain unaffected by cut-off effects even on this coarse lattice, while the tree level action becomes sensitive to the cut-off. For the surface tension and latent heat we find $\\sigma_I/ T_c^3 = 0.0155~(16)$ and $\\Delta\\epsilon/T_c^4 = 1.40~(9)$, respectively.

  4. Analysis of Senate Bill 961: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2010-01-01

    endometrial cancer, ovarian cancer, uterine cancer, andagents No Epithelial ovarian cancer, Hodgkins lymphomacancer, endometrial cancer, ovarian cancer, uterine sarcoma

  5. BREAST CANCER SUPPORT RESOURCES Smilow Cancer Hospital

    E-Print Network [OSTI]

    O'Hern, Corey S.

    BREAST CANCER SUPPORT RESOURCES Smilow Cancer Hospital Early Stage Breast Cancer Support Group Advanced Stage Cancer Support Group IMPACT Young Cancer Survivors' Group Contact: Angela Khairallah, LCSW at 203-200-2360 Reach to Recovery American Cancer Society 1-800-227-2345 www.cancer.org Sisters

  6. Method for charging and discharging a latent-heat storage medium and heat storage

    SciTech Connect (OSTI)

    Kreikenbohm, R.; Reusch, H.

    1982-12-28

    A heat storage unit is disclosed having a vertically cylindrical container accommodating a latent-heat storage medium and a conduit introducing a heat carrier liquid not miscible with the medium at the bottom of the container. The conduit has an exit nozzle which is located outside the axial center of the cylinder and nearly perpendicular to the radius of the cylinder so that the heat carrier liquid enters the cylinder at the bottom in a direction to cause the heat storage melt to be set into a rotary motion.

  7. Method for charging and discharging a latent-heat storage medium and heat storage

    SciTech Connect (OSTI)

    Kreikenbohm, R.; Reusch, H.

    1981-10-13

    A heat storage unit is disclosed having a vertically cylindrical container accommodating a latent-heat storage medium and a conduit introducing a heat carrier liquid not miscible with the medium at the bottom of the container. The conduit has an exit nozzle which is located outside the axial center of the cylinder and nearly perpendicular to the radius of the cylinder so that the heat carrier liquid enters the cylinder at the bottom in a direction to cause the heat storage melt to be set into a rotary motion.

  8. PHYS 101 Lecture 37 -Latent heat and specific heat 37 -1 2001 by David Boal, Simon Fraser University. All rights reserved; further copying or resale is strictly prohibited.

    E-Print Network [OSTI]

    Boal, David

    PHYS 101 Lecture 37 - Latent heat and specific heat 37 - 1 2001 by David Boal, Simon Fraser and specific heat What's important: latent heat at a phase change specific heat of gases Demonstrations and specific heat 37 - 2 2001 by David Boal, Simon Fraser University. All rights reserved; further copying

  9. Analysis of Assembly Bill 1000: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    endometrial cancer, ovarian cancer, uterine cancer, andagents No Epithelial ovarian cancer, melanoma, multiplein advanced, inoperable ovarian cancer; used as palliative

  10. A Framework for Incorporating General Domain Knowledge into Latent Dirichlet Allocation using First-Order Logic

    SciTech Connect (OSTI)

    Andrzejewski, D; Zhu, X; Craven, M; Recht, B

    2011-01-18

    Topic models have been used successfully for a variety of problems, often in the form of application-specific extensions of the basic Latent Dirichlet Allocation (LDA) model. Because deriving these new models in order to encode domain knowledge can be difficult and time-consuming, we propose the Fold-all model, which allows the user to specify general domain knowledge in First-Order Logic (FOL). However, combining topic modeling with FOL can result in inference problems beyond the capabilities of existing techniques. We have therefore developed a scalable inference technique using stochastic gradient descent which may also be useful to the Markov Logic Network (MLN) research community. Experiments demonstrate the expressive power of Fold-all, as well as the scalability of our proposed inference method.

  11. Heat Transfer and Latent Heat Storage in Inorganic Molten Salts for Concentrating Solar Power Plants

    SciTech Connect (OSTI)

    Mathur, Anoop

    2013-08-14

    A key technological issue facing the success of future Concentrating Solar Thermal Power (CSP) plants is creating an economical Thermal Energy Storage (TES) system. Current TES systems use either sensible heat in fluids such as oil, or molten salts, or use thermal stratification in a dual-media consisting of a solid and a heat-transfer fluid. However, utilizing the heat of fusion in inorganic molten salt mixtures in addition to sensible heat , as in a Phase change material (PCM)-based TES, can significantly increase the energy density of storage requiring less salt and smaller containers. A major issue that is preventing the commercial use of PCM-based TES is that it is difficult to discharge the latent heat stored in the PCM melt. This is because when heat is extracted, the melt solidifies onto the heat exchanger surface decreasing the heat transfer. Even a few millimeters of thickness of solid material on heat transfer surface results in a large drop in heat transfer due to the low thermal conductivity of solid PCM. Thus, to maintain the desired heat rate, the heat exchange area must be large which increases cost. This project demonstrated that the heat transfer coefficient can be increase ten-fold by using forced convection by pumping a hyper-eutectic salt mixture over specially coated heat exchanger tubes. However,only 15% of the latent heat is used against a goal of 40% resulting in a projected cost savings of only 17% against a goal of 30%. Based on the failure mode effect analysis and experience with pumping salt at near freezing point significant care must be used during operation which can increase the operating costs. Therefore, we conclude the savings are marginal to justify using this concept for PCM-TES over a two-tank TES. The report documents the specialty coatings, the composition and morphology of hypereutectic salt mixtures and the results from the experiment conducted with the active heat exchanger along with the lessons learnt during experimentation.

  12. Josephine Ford Cancer Center Cancer Research Programs

    E-Print Network [OSTI]

    Finley Jr., Russell L.

    Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

  13. Comprehensive Cancer Center Nutrition

    E-Print Network [OSTI]

    Anderson, Paul R.

    Comprehensive Cancer Center Nutrition Bldg.Pedestrian Link from Ardmore Tower to Comprehensive Cancer Center on Ground Floor Emergency Room Parking Ardmore Cafeteria Ardmore Tower North Tower Janeway

  14. Exploring potential R&D collaboration partners through patent analysis based on bibliographic coupling and latent semantic analysis

    E-Print Network [OSTI]

    Park, I.; Jeong, Y.; Yoon, B.; Mortara, L.

    2014-10-22

    or complex matrix in linear algebra, is used to estimate the latent structure, and to get rid of the obscuring noise in LSA. The LSA model scored as well as that of second-language English speakers, as evidenced by scores on the Test of English as a... within top 15 technological similarity scores and the map by LSA matches three pairs among six real collaboration pairs within top 10 technological similarity scores. Figure 9. R&D collaboration state map at the second period (1995-2004) 5...

  15. Lung Cancer James Nguyen

    E-Print Network [OSTI]

    Brutlag, Doug

    Lung Cancer James Nguyen Biochemistry 118Q Doug Brutlag A Case Study of Genetics and Environment #12;Lung Cancer Leading cause of cancer for men and women in United States Every year, about 164,000 new cases are diagnosed in the US, with an estimated 157,000 deaths. Leading cause of cancer death

  16. The National Cancer Institute,

    E-Print Network [OSTI]

    The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

  17. AT NORTHWESTERN EARLY CANCER DETECTION

    E-Print Network [OSTI]

    Chisholm, Rex L.

    --including lung cancer, pancreatic cancer, and ovarian cancer-- there is simply no screening option available, such as pancreatic, ovarian, and lung cancer. Improve existing screening techniques, such as those for colon cancer, with the THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE EARLY CANCER DETECTION TECHNOLOGIES INSTITUTE

  18. CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER

    E-Print Network [OSTI]

    Sherman, S. Murray

    CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

  19. Cancer Stage at Diagnosis, 2013

    E-Print Network [OSTI]

    2013-01-01

    of avoiding death due to a particular cancer. Stage atdiagnosis by the American Joint Committee on Cancer (AJCC) Cancer Staging Manual, sixth edition. Source:

  20. Targeting ILK and {beta}4 integrin abrogates the invasive potential of ovarian cancer

    SciTech Connect (OSTI)

    Choi, Yoon Pyo; Kim, Baek Gil; Department of Pathology, Yonsei University College of Medicine, Seoul ; Gao, Ming-Qing; Kang, Suki; Cho, Nam Hoon

    2012-10-26

    Highlights: Black-Right-Pointing-Pointer The potential of targeting ILK and integrins for highly aggressive ovarian cancer. Black-Right-Pointing-Pointer Unanticipated synergistic effect for the combination of ILK/{beta}4 integrin. Black-Right-Pointing-Pointer Combination of ILK/{beta}4 integrin effectively inhibited the PI3K/Akt/Rac1 cascade. Black-Right-Pointing-Pointer Targeting of {beta}4 integrin/ILK had potent inhibitory effects in ovarian cancer. -- Abstract: Integrins and integrin-linked kinase (ILK) are essential to cancerous invasion because they mediate physical interactions with the extracellular matrix, and regulate oncogenic signaling pathways. The purpose of our study is to determine whether deletion of {beta}1 and {beta}4 integrin and ILK, alone or in combination, has antitumoral effects in ovarian cancer. Expression of {beta}1 and {beta}4 integrin and ILK was analyzed by immunohistochemistry in 196 ovarian cancer tissue samples. We assessed the effects of depleting these molecules with shRNAs in ovarian cancer cells by Western blot, conventional RT-PCR, cell proliferation, migration, invasion, and in vitro Rac1 activity assays, and in vivo xenograft formation assays. Overexpression of {beta}4 integrin and ILK in human ovarian cancer specimens was found to correlate with tumor aggressiveness. Depletion of these targets efficiently suppresses ovarian cancer cell proliferation, migration, and invasion in vitro and xenograft tumor formation in vivo. We also demonstrated that single depletion of ILK or combination depletion of {beta}4 integrin/ILK inhibits phosphorylation of downstream signaling targets, p-Ser 473 Akt and p-Thr202/Tyr204 Erk1/2, and activation of Rac1, as well as reduce expression of MMP-2 and MMP-9 and increase expression of caspase-3 in vitro. In conclusion, targeting {beta}4 integrin combined with ILK can instigate the latent tumorigenic potential and abrogate the invasive potential in ovarian cancer.

  1. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

    E-Print Network [OSTI]

    2006-01-01

    1996): Nutrition and breast cancer. Cancer Causes Control 7:of premenopausal breast cancer. Cancer Epidemiol.BiomarkersDiagnosis Weight Gain and Breast Cancer Recurrence In Women

  2. Familial Breast Cancer Julie Saffarian

    E-Print Network [OSTI]

    Brutlag, Doug

    Familial Breast Cancer Julie Saffarian Genomics & Medicine Stanford University #12;Definitions metastasis" Wikipedia.com What is Breast Cancer? - Breast Cancer is a disease in which the uncontrollable Breast Cancer? - Sporadic Breast Cancer is non-hereditary and represents 85-90% of Cancer cases

  3. Regional CO2 and latent heat surface fluxes in the Southern Great Plains: Measurements, modeling, and scaling

    SciTech Connect (OSTI)

    Riley, W. J.; Biraud, S.C.; Torn, M.S.; Fischer, M.L.; Billesbach, D.P.; Berry, J.A.

    2009-08-15

    Characterizing net ecosystem exchanges (NEE) of CO{sub 2} and sensible and latent heat fluxes in heterogeneous landscapes is difficult, yet critical given expected changes in climate and land use. We report here a measurement and modeling study designed to improve our understanding of surface to atmosphere gas exchanges under very heterogeneous land cover in the mostly agricultural U.S. Southern Great Plains (SGP). We combined three years of site-level, eddy covariance measurements in several of the dominant land cover types with regional-scale climate data from the distributed Mesonet stations and Next Generation Weather Radar precipitation measurements to calibrate a land surface model of trace gas and energy exchanges (isotope-enabled land surface model (ISOLSM)). Yearly variations in vegetation cover distributions were estimated from Moderate Resolution Imaging Spectroradiometer normalized difference vegetation index and compared to regional and subregional vegetation cover type estimates from the U.S. Department of Agriculture census. We first applied ISOLSM at a 250 m spatial scale to account for vegetation cover type and leaf area variations that occur on hundred meter scales. Because of computational constraints, we developed a subsampling scheme within 10 km 'macrocells' to perform these high-resolution simulations. We estimate that the Atmospheric Radiation Measurement Climate Research Facility SGP region net CO{sub 2} exchange with the local atmosphere was -240, -340, and -270 gC m{sup -2} yr{sup -1} (positive toward the atmosphere) in 2003, 2004, and 2005, respectively, with large seasonal variations. We also performed simulations using two scaling approaches at resolutions of 10, 30, 60, and 90 km. The scaling approach applied in current land surface models led to regional NEE biases of up to 50 and 20% in weekly and annual estimates, respectively. An important factor in causing these biases was the complex leaf area index (LAI) distribution within cover types. Biases in predicted weekly average regional latent heat fluxes were smaller than for NEE, but larger than for either ecosystem respiration or assimilation alone. However, spatial and diurnal variations of hundreds of W m{sup -2} in latent heat fluxes were common. We conclude that, in this heterogeneous system, characterizing vegetation cover type and LAI at the scale of spatial variation are necessary for accurate estimates of bottom-up, regional NEE and surface energy fluxes.

  4. Cancer: A suppression switch

    E-Print Network [OSTI]

    Starobinets, H; Debnath, J

    2013-01-01

    Cancer A suppression switch The status of the protein p53it seems that p53 acts as a switch in pancreatic cancer thatthe ability of p53 to switch the clinical outcome of

  5. Comprehensive Cancer Center Nutrition

    E-Print Network [OSTI]

    Anderson, Paul R.

    Comprehensive Cancer Center Nutrition Bldg.Pedestrian Link from Ardmore Tower to Comprehensive Cancer Center on Ground Floor Emergency Room Parking Pedestrian Link to Parking on 4th Floor Surgical

  6. Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA15 pathway

    E-Print Network [OSTI]

    Poole, Emma; Lau, Jonathan; Sinclair, John

    2015-05-08

    ., Breidenstein, A. & Compton, T. (2012). Human cytomegalovirus activation of ERK 214 and myeloid cell leukemia-1 protein correlates with survival of latently infected cells. Proc 215 Natl Acad Sci U S A 109, 588-593. 216 Reeves, M. B., MacAry, P. A., Lehner, P...

  7. PROSTATE CANCER EVIDENCE ACADEMY

    E-Print Network [OSTI]

    Bushman, Frederic

    PROSTATE CANCER EVIDENCE ACADEMY CME/CNE-Certified Course The Inn at Penn 3600 Sansom Street:30 PM R E G I S T E R O N L I N E AT PENNCMEONLINE.COM/NODE/57378 #12;OVERVIEW The Prostate Cancer, and model programs that are proven effective or being studied to improve prostate cancer prevention, control

  8. Evidence That New Hypnotics Cause Cancer

    E-Print Network [OSTI]

    Kripke, Daniel F.

    2008-01-01

    use and risk of epithelial ovarian cancer. Cancer Epidemiol.and risk of epithelial ovarian cancer: evidence from twowere associated with ovarian cancer (Harlow et al. 1998;

  9. FIGHTING CANCER Cancer Research at the University of Notre Dame

    E-Print Network [OSTI]

    Buechler, Steven

    FIGHTING CANCER Cancer Research at the University of Notre Dame College of Science 168 Hurley Hall Fighting Cancer 5 Ani Aprahamian Isotopes for cancer therapy and immuno-diagnosis 7 Brian Baker Development of improved immunological therapies for cancer based on cellular immunity 9 Suzanne Bohlson Inflammation

  10. CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER SYNDROME (HBOC) BRCA1 PATIENT INFORMATION What is Hereditary Breast and Ovarian Cancer syndrome? Hereditary Breast and Ovarian Cancer syndrome (HBOC) is the most common hereditary form of breast and ovarian cancer. About 2% of women

  11. Cancer Due to Prolonged Inflammation

    E-Print Network [OSTI]

    Lingampalli, Nithya

    2013-01-01

    Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

  12. Bismuth 213 Cancer Treatment

    ScienceCinema (OSTI)

    None

    2013-05-28

    See how INL scientists are increasing supplies of radioactive medical isotopes to treat cancer. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  13. Sample-Specific Cancer Pathway Analysis Using PARADIGM

    E-Print Network [OSTI]

    Benz, Stephen Charles

    2012-01-01

    associated with Ovarian Cancer 29 3.2.3 Di?erentiallyOvarian Cancer . . . . . . . . . . . . . . . . . . . . . .Ovarian Cancer) . . . . . . . . . . . . . . . . . . . . . .

  14. SOARCA Peach Bottom Atomic Power Station Long-Term Station Blackout Uncertainty Analysis: Convergence of the Uncertainty Results

    SciTech Connect (OSTI)

    Bixler, Nathan E.; Osborn, Douglas M.; Sallaberry, Cedric Jean-Marie; Eckert-Gallup, Aubrey Celia; Mattie, Patrick D.; Ghosh, S. Tina

    2014-02-01

    This paper describes the convergence of MELCOR Accident Consequence Code System, Version 2 (MACCS2) probabilistic results of offsite consequences for the uncertainty analysis of the State-of-the-Art Reactor Consequence Analyses (SOARCA) unmitigated long-term station blackout scenario at the Peach Bottom Atomic Power Station. The consequence metrics evaluated are individual latent-cancer fatality (LCF) risk and individual early fatality risk. Consequence results are presented as conditional risk (i.e., assuming the accident occurs, risk per event) to individuals of the public as a result of the accident. In order to verify convergence for this uncertainty analysis, as recommended by the Nuclear Regulatory Commissions Advisory Committee on Reactor Safeguards, a high source term from the original population of Monte Carlo runs has been selected to be used for: (1) a study of the distribution of consequence results stemming solely from epistemic uncertainty in the MACCS2 parameters (i.e., separating the effect from the source term uncertainty), and (2) a comparison between Simple Random Sampling (SRS) and Latin Hypercube Sampling (LHS) in order to validate the original results obtained with LHS. Three replicates (each using a different random seed) of size 1,000 each using LHS and another set of three replicates of size 1,000 using SRS are analyzed. The results show that the LCF risk results are well converged with either LHS or SRS sampling. The early fatality risk results are less well converged at radial distances beyond 2 miles, and this is expected due to the sparse data (predominance of zero results).

  15. Inflammation & Inflammation & cancer

    E-Print Network [OSTI]

    Beimel, Amos

    Tam & tnf dc cytokines metastasis metabolism #12;22 chemokine gradient in cancer (Balkwill et al. 2004 1861) Wound healing dc Tam & tnf cytokines metastasis therapeutics metabolism inflammation The end #12 & tnf cytokines metastasis metabolism #12;4 Motivation Cancer as an overhealing wound Lets Go! Wound

  16. Cancer Cell Survival of Cancer Cells Is Maintained

    E-Print Network [OSTI]

    Leps, Jan "Suspa"

    Cancer Cell Article Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase,* and Mien-Chie Hung2,* 1Department of Cancer Biology 2Department of Molecular and Cellular Oncology The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA 3Present

  17. Mathematics for Cancer Research making optimal use of cancer data

    E-Print Network [OSTI]

    Coolen, ACC "Ton"

    Mathematics for Cancer Research making optimal use of cancer data ACC Coolen King's College London ACC Coolen (KCL) Mathematics in cancer research January 2015 1 / 63 #12;1 Quality of raw data Bayesian projects ... ACC Coolen (KCL) Mathematics in cancer research January 2015 2 / 63 #12;biomedical research

  18. CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER SYNDROME (HBOC) BRCA2 PATIENT INFORMATION What is Hereditary Breast and Ovarian Cancer syndrome? People with BRCA2 alterations have a genetic condition called Hereditary Breast and Ovarian Cancer syndrome (HBOC). HBOC is caused by an error

  19. Digital Tomosynthesis: Advanced Breast Cancer

    E-Print Network [OSTI]

    Hansma, Paul

    Digital Tomosynthesis: Advanced Breast Cancer Imaging Technique Max Wiedmann #12;Digital in CT. #12;Breast Cancer The leading Cause of death for women ages 40-55. Is only behind lung and bronchus cancer in terms of number of deaths in US. Early detection of breast cancer is believed to save

  20. Survivorship Clinic Nutrition after Cancer

    E-Print Network [OSTI]

    Brent, Roger

    Survivorship Clinic Nutrition after Cancer Surviving cancer has a way of changing the way you look of practical, everyday questions that accompany life as a cancer survivor: Now what? How should I live successful treatment and are now leading vital, cancer- free lives. Maybe your doctor or dietitian has

  1. QUESTIONS & ANSWERS ABOUT LUNG CANCER

    E-Print Network [OSTI]

    QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

  2. Evidence That New Hypnotics Cause Cancer

    E-Print Network [OSTI]

    Kripke, Daniel F.

    2008-01-01

    medication use and risk of epithelial ovarian cancer.Cancer Epidemiol. Biomarkers Prev. , Hays, J. C. , Blazer,the likelihood of cancer causation is sufficiently strong

  3. Targeting mTOR in Pancreatic Cancer

    E-Print Network [OSTI]

    Soares, Heloisa Prado

    2015-01-01

    Parsons J, Kern SE. Progression model for pancreatic cancer.Clinical Cancer Research. 2000;6(N8):2969-72.Martinelli P. Pancreatic Cancer Development and Progression:

  4. Aneuploidy: Cancer's Fatal Flaw?

    E-Print Network [OSTI]

    Williams, Bret R.

    Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we ...

  5. Eye Cancer- Cobalt Treatment

    E-Print Network [OSTI]

    Unknown

    2011-08-17

    Ductal carcinoma in situ (DCIS) has been shown to be a precursor to invasive ductal cancer (IDC). Though the progression of DCIS to IDC is believed to be an important aspect of tumor aggressiveness, prognosis and molecular markers that predict...

  6. Targeting Breast Cancer Metastasis

    E-Print Network [OSTI]

    Mu, Ping

    Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 3040% of patients may eventually suffer from distant relapse and ...

  7. Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer

    E-Print Network [OSTI]

    Weber, David J.

    Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer Associate Professor Tenuretrack Health is expanding research in Cancer Genetic Epidemiology to enrich an already robust campuswide

  8. Colorectal cancer and diet in Scotland

    E-Print Network [OSTI]

    Theodoratou, Evropi

    2008-01-01

    Introduction Colorectal cancer is a cancer that forms in the tissues of the colon and/ or rectum and more than 95% of colorectal cancers are adenocarcinomas. It is the third most common cancer in incidence and mortality ...

  9. Hollow nanoshells for cancer diagnostics and therapy

    E-Print Network [OSTI]

    Sandoval, Sergio

    2012-01-01

    Protein Is a Marker for Ovarian-Cancer. Cancer Research,binding protein in ovarian cancers. International Journal ofTrophoblast and Ovarian-Cancer Antigen-Lk26 - Sensitivity

  10. Dynamic Latent Plan Models

    E-Print Network [OSTI]

    Choudhury, Charisma F.

    Planning is an integral part of many behavioural aspects related to transportation: residential relocation, activity and travel scheduling, route choice, etc. People make plans and then select actions to execute those ...

  11. CHEST Supplement Screening for Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    e78S CHEST Supplement Screening for Lung Cancer DIAGNOSIS AND MANAGEMENT OF LUNG CANCER, 3RD ED individuals). 3.2.2. In patients at risk for developing lung cancer, screening for lung cancer with sputum are age 55 to 74 and who have smoked for Background: Lung cancer is by far the major cause of cancer

  12. Pegfilgrastim prophylaxis is associated with a lower risk of hospitalization of cancer patients than filgrastim prophylaxis: a retrospective United States claims analysis of granulocyte colony-stimulating factors (G-CSF)

    E-Print Network [OSTI]

    2013-01-01

    cancer, lung cancer, ovarian cancer, or colorectal cancer.cancer, lung cancer, ovarian cancer, or colorectal cancerlung cancer, NHL, ovarian cancer, or colorectal cancer

  13. Cell Senescence: Aging and Cancer

    ScienceCinema (OSTI)

    Campisi, Judith

    2013-05-29

    Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

  14. Early Lung Cancer Detection Program

    Broader source: Energy.gov [DOE]

    Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

  15. Hindawi Publishing Corporation Prostate Cancer

    E-Print Network [OSTI]

    Ahn, Hongshik

    Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 176164, 7 pages doi:10.1155/2011/176164 Clinical Study Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone

  16. Cancer Therapy with Particle Beams

    E-Print Network [OSTI]

    Olszewski Jr., Edward A.

    Cancer Therapy with Particle Beams #12; The potential to use high energy particle beams to treat many types of cancer has been known even before their creation. The availability of these treatments to be used in medicine, specifically for the treatment of certain cancers. His paper was published when

  17. Potential molecular targeting of splice variants for cancer treatment

    E-Print Network [OSTI]

    Blair, Christopher A; Zi, Xiaolin

    2011-01-01

    isoform contributes to ovarian cancer progression. Molin taxane-resistant ovarian cancer. Clin Cancer Res. 2011;Recent report in ovarian cancer has identified tumor-

  18. Diabetes and breast cancer : the women's healthy eating & living study

    E-Print Network [OSTI]

    Erickson, Kirsten Diann

    2011-01-01

    or experience significant weight gain after breast cancer.cohort of early-stage breast cancer patients [abstract]. Ja history of early stage breast cancer. Breast Cancer Res

  19. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

    E-Print Network [OSTI]

    2006-01-01

    Hunter DJ, Willett WC (1996): Nutrition and breast cancer.Cancer Causes Control 7:56- 37. Weiderpass E, Braaten T,of premenopausal breast cancer. Cancer Epidemiol.Biomarkers

  20. Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer

    E-Print Network [OSTI]

    Spellman, Paul T.

    2011-01-01

    RahmanN. ATMandbreastcancersusceptibility. Oncogenegenesforinheritedbreastcancer. CancerCell2007;11:studyidentifiesnovelbreast cancersusceptibilityloci.

  1. Plant Disease Note 2005 | First Report of Onion yellow dwarf virus, Leek ye... stripe virus, and Garlic common latent virus in Garlic in Washington State Overview Current Issue Past Issues Search PD Search APS Journals

    E-Print Network [OSTI]

    Pappu, Hanu R.

    Plant Disease Note 2005 | First Report of Onion yellow dwarf virus, Leek ye... stripe virus, and Garlic common latent virus in Garlic in Washington State Overview Current Issue Past Issues Search PD-2006 The American Phytopathological Society First Report of Onion yellow dwarf virus, Leek yellow stripe virus

  2. Apple latent spherical virus vectors for reliable and effective virus-induced gene silencing among a broad range of plants including tobacco, tomato, Arabidopsis thaliana, cucurbits, and legumes

    SciTech Connect (OSTI)

    Igarashi, Aki; Yamagata, Kousuke; Sugai, Tomokazu; Takahashi, Yukari; Sugawara, Emiko; Tamura, Akihiro; Yaegashi, Hajime; Yamagishi, Noriko; Takahashi, Tsubasa; Isogai, Masamichi; Takahashi, Hideki; Yoshikawa, Nobuyuki

    2009-04-10

    Apple latent spherical virus (ALSV) vectors were evaluated for virus-induced gene silencing (VIGS) of endogenous genes among a broad range of plant species. ALSV vectors carrying partial sequences of a subunit of magnesium chelatase (SU) and phytoene desaturase (PDS) genes induced highly uniform knockout phenotypes typical of SU and PDS inhibition on model plants such as tobacco and Arabidopsis thaliana, and economically important crops such as tomato, legume, and cucurbit species. The silencing phenotypes persisted throughout plant growth in these plants. In addition, ALSV vectors could be successfully used to silence a meristem gene, proliferating cell nuclear antigen and disease resistant N gene in tobacco and RCY1 gene in A. thaliana. As ALSV infects most host plants symptomlessly and effectively induces stable VIGS for long periods, the ALSV vector is a valuable tool to determine the functions of interested genes among a broad range of plant species.

  3. Colon Cancer Is colon cancer a func.on of race or gene.cs?

    E-Print Network [OSTI]

    Brutlag, Doug

    Colon Cancer Is colon cancer a func.on of race or gene.cs? #12;Colon Cancer What is colon cancer? What genes are associated with colon cancer? What external factors contribute to colon cancer? What is done to diagnose

  4. THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE

    E-Print Network [OSTI]

    Chisholm, Rex L.

    THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE INTERNATIONAL RELATIONS PROGRAM THE INSTITUTES AT NORTHWESTERN MEDICINE #12;To maximize Northwestern's scientific contributions to the field of cancer Comprehensive Cancer Center of Northwestern University are partnering to create robust research collaborations

  5. Diet, MicroRNAs and Prostate Cancer

    E-Print Network [OSTI]

    Saini, Sharanjot; Majid, Shahana; Dahiya, Rajvir

    2010-01-01

    deregulation in human cancer. Cell Cycle. 2008;7:26436. 25.genomic regions involved in cancers. Proc Natl Acad Sci USA.A, Jacks T. MicroRNAs and cancer: short RNAs go a long way.

  6. Analysis of Senate Bill 255: Breast Cancer

    E-Print Network [OSTI]

    California Health Benefits Review Program

    2011-01-01

    women with stage 1 or II breast cancer who Lumpectomy plus=1.06 (0.56-2.00) II breast cancer who received mastectomya Fact Sheet on Breast Cancer Surgery/Partial Mastectomies

  7. YY1 modulates taxane response in epithelial ovarian cancer

    E-Print Network [OSTI]

    Matsumura, Noriomi

    2009-01-01

    A), but not to cisplatin (B) in ovarian cancer cell lines.al. Human epithelial ovarian cancer allelotype. Cancer Resallelotyping of human ovarian cancer. Br J Cancer 1994;69(

  8. Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk

    E-Print Network [OSTI]

    2009-01-01

    1996. Cigarette smoking and breast cancer. Cancer Epidemiol.Cigarette smoking and breast cancer. BMJ 310, 1431-1433.smoking, and the risk of breast cancer. Cancer Detect. Prev.

  9. Mathematical Toolkit Unlocks Some Cancer Secrets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mathematical Models Shed New Light on Cancer Mutations Mathematical Models Shed New Light on Cancer Mutations Calculations Run at NERSC Pinpoint Rare Mutants More Quickly November...

  10. Developed by the Yale Lung Screening and Nodule Program at Yale Cancer Center Smilow Cancer Hospital at Yale-New Haven Copyright 2013, Yale Cancer Center

    E-Print Network [OSTI]

    O'Hern, Corey S.

    Developed by the Yale Lung Screening and Nodule Program at Yale Cancer Center Smilow Cancer Hospital at Yale-New Haven Copyright 2013, Yale Cancer Center Summary of Lung Cancer Screening Guidelines Program American Cancer Society (ACS) American Cancer Society. Interim Guidance on Lung Cancer Screening

  11. Breakthrough: Fighting Cancer with Nanoparticles

    ScienceCinema (OSTI)

    Rozhkova, Elena

    2013-04-19

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  12. Breakthrough: Fighting Cancer with Nanoparticles

    SciTech Connect (OSTI)

    Rozhkova, Elena

    2012-01-01

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  13. KEY FACTS The Alvin J. Siteman Cancer Center is a National Cancer Institute (NCI) designated comprehensive cancer

    E-Print Network [OSTI]

    Subramanian, Venkat

    KEY FACTS The Alvin J. Siteman Cancer Center is a National Cancer Institute (NCI) designated comprehensive cancer center, the only one in Missouri and within a 240 that would speed discoveries in the lab into actual patient care. In 2009, Siteman Cancer

  14. Genetics of Hereditary Breast and Ovarian Cancer The majority of cancer cases are not attributable to hereditary causes. However, cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    May 2013 Genetics of Hereditary Breast and Ovarian Cancer The majority of cancer cases are not attributable to hereditary causes. However, cancer can be hereditary in some families. There are many factors that can increase the probability that the cancers in a family may be hereditary. Some of these factors are

  15. Prognostic and therapeutic relevance of molecular subtypes in high-grade serous ovarian cancer.

    E-Print Network [OSTI]

    2014-01-01

    targeted therapies in ovarian cancer. Nat Rev Cancer. 2009;Brief Communication | JNCI ovarian cancer linked to clinicaldebulked patients with ovarian cancer. Cancer Res. 2008;68(

  16. A Million Cancer Genome Warehouse David Haussler

    E-Print Network [OSTI]

    McAuliffe, Jon

    Warehouse Regional Warehouses Design and Cost to Build and Operate a Million Cancer Genome Warehouse CAPEX

  17. What Lung Cancer Patients Need to Know

    E-Print Network [OSTI]

    Kaski, Samuel

    What Lung Cancer Patients Need to Know About Bone Health A Publication of The Bone and Cancer Foundation #12;Contents THIS PUBLICATION PROVIDES IMPORTANT INFORMATION ABOUT THE RELATIONSHIP BETWEEN LUNG CANCER AND BONE HEALTH. HOW BONE WORKS (PAGE 2). WHAT LUNG CANCER CAN DO TO BONE (PAGE 2). TREATING BONE

  18. Pancreatic Cancer Clinical Trials Guest Expert

    E-Print Network [OSTI]

    O'Hern, Corey S.

    about pancreatic cancer. In the United States in 2014 we are expecting to see about 45,000 cases and unfortunately, the death rate is about 40,000 deaths from pancreas cancer and although it is actually uncommon, only about 3% of all cancers diagnosed in the United States are pancreatic cancer, it is in fact

  19. AGE -A HEA Cancer FoRs

    E-Print Network [OSTI]

    Balasuriya, Sanjeeva

    CANCER CANCER R REVIEW D DR ADAM B FoRs RESEARCH DOCUMENT BUTLER, RE H COVERA T ESEARCH P AGE;Cancer FoRs 5 June 2013 Page 2 BACKGROUND This document was created for the Health and Medical Research Strategic Review and attempts to outline the coverage of cancer research throughout the university

  20. colon cancer Can genetics help tackle

    E-Print Network [OSTI]

    Rasdeaconu, Rares

    Predicting colon cancer Can genetics help tackle the second leading cancer killer? momentum without cancer. #12;EDITOR Melissa Marino CONTRIBUTING WRITERS Stephanie Crowe Leigh MacMillan Cynthia, TN 37232-2390 (615) 322-4747 Momentum is published twice a year by Vanderbilt-Ingram Cancer Center

  1. TARGETING CANCER STEM CELLS Summary of technology

    E-Print Network [OSTI]

    Mucina, Ladislav

    TARGETING CANCER STEM CELLS Summary of technology Cancerstemcells(CSCs)playasignificantroleinleukemia, glioma, and breast, lung, gastrointestinal, prostate and ovarian cancer etiology, causing therapy of a new adjunct for targeted therapy of cancer involving CSCs, for use in combination with existing cancer

  2. Contact Details Journeying Beyond Breast Cancer

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    Home About Contact Details Facebook Search Journeying Beyond Breast Cancer making sense of the cancer experience Feeds: Posts Comments Cancer-fighting fountain pen May 20, 2009 by JBBC A research team be used both as a research tool in the development of next-generation cancer treatments

  3. Breast Cancer and Genetic Testing Mari Suzuki

    E-Print Network [OSTI]

    Brutlag, Doug

    Breast Cancer and Genetic Testing Mari Suzuki BIOCHEM 118Q Professor Doug Brutlag Spring 2005 #12, which is often referred to as the breast cancer gene. My mother had fought off breast cancer and she the mutation means it's almost certain that I will develop breast cancer at some point in my life. It also

  4. Dominant Negative ATM Mutations in Breast Cancer Families

    E-Print Network [OSTI]

    Nyholt, Dale R.

    cancer fami- lies containing members with ovarian cancer or male breast cancer (1). However, mutations of female breast cancer but no cases of male breast cancer or ovarian cancer (1). It is, therefore, likelyDominant Negative ATM Mutations in Breast Cancer Families Georgia Chenevix-Trench, Amanda B

  5. Role for a region of helically unstable DNA within the Epstein-Barr virus latent cycle origin of DNA replication oriP in origin function

    SciTech Connect (OSTI)

    Polonskaya, Zhanna; Benham, Craig J.; Hearing, Janet . E-mail: jhearing@ms.cc.sunysb.edu

    2004-10-25

    The minimal replicator of the Epstein-Barr virus (EBV) latent cycle origin of DNA replication oriP is composed of two binding sites for the Epstein-Barr virus nuclear antigen-1 (EBNA-1) and flanking inverted repeats that bind the telomere repeat binding factor TRF2. Although not required for minimal replicator activity, additional binding sites for EBNA-1 and TRF2 and one or more auxiliary elements located to the right of the EBNA-1/TRF2 sites are required for the efficient replication of oriP plasmids. Another region of oriP that is predicted to be destabilized by DNA supercoiling is shown here to be an important functional component of oriP. The ability of DNA fragments of unrelated sequence and possessing supercoiled-induced DNA duplex destabilized (SIDD) structures, but not fragments characterized by helically stable DNA, to substitute for this component of oriP demonstrates a role for the SIDD region in the initiation of oriP-plasmid DNA replication.

  6. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The selenium and vitamin E cancer prevention trial (SELECT)

    E-Print Network [OSTI]

    2009-01-01

    PR, Albanes D. Selenium, vitamin E, and prostate cancer--Effect of Selenium and Vitamin E on Risk of Prostate CancerOther Cancers: The Selenium and Vitamin E Cancer Prevention

  7. Markers of chemically induced cancer

    SciTech Connect (OSTI)

    Freeman, G.; Milman, H.A. (eds.)

    1984-01-01

    This book is a concise review and evaluation of available data for recognizing and measuring markers of cancer or oncogenesis provoked in vivo by chemicals using relatively short-term experiments in animals. This review focuses on biochemical and immunological changes that correlate with carcinogenicity. Such ''markers,'' if occurring early enough, may be used to predict the onset of cancer in experimental animals exposed to potential chemical carcinogens long before morphological changes are seen. It is by examining all the information available about the potential carcinogenicity of chemicals that proper decisions can be made towards limiting the risk of cancer due to exposure to chemical carcinogens.

  8. The Cancer Genome Atlas Pan-Cancer analysis project

    E-Print Network [OSTI]

    Lander, Eric S.

    The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a ...

  9. Stromal Modulation of Radiation Carcinogenesis in Breast Cancer

    E-Print Network [OSTI]

    Nguyen, David Hiendat Hua

    2011-01-01

    receptor-negative breast cancer patients. J Clin Invest 120,Triple-Negative Breast Cancer: Distinguishing between Basaland Nonbasal Subtypes. Clin Cancer Res 15, 2302-2310. Reis-

  10. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein...

  11. School Response to Families with Children with Cancer

    E-Print Network [OSTI]

    Nielsen, Shelley Lynn

    2010-01-01

    Coping with childhood cancer: Where do we go from here?issues in childhood cancer. School Psychology Review, 28(2),2001). Children surviving cancer: Psychosocial adjustment,

  12. Approaches to identifying synthetic lethal interactions in cancer

    E-Print Network [OSTI]

    Thompson, JM; Nguyen, QH; Singh, M; Razorenova, OV

    2015-01-01

    options in recurrent ovarian cancer: latest evidence andsensitive relapsed ovarian cancer. N Engl J Med. 2012;366:29. Agarwal R, Kaye SB. Ovarian cancer: strategies for over-

  13. Mapping Dysregulated Metabolic Pathways in Cancer Using Functional Metabolomic Platforms

    E-Print Network [OSTI]

    Benjamin, Daniel Isaac

    2015-01-01

    al. Adipocytes promote ovarian cancer metastasis and provideterm migration of human ovarian cancer cells. Cell Communand invasion of ovarian cancer cells, through direct

  14. Stromal Modulation of Radiation Carcinogenesis in Breast Cancer

    E-Print Network [OSTI]

    Nguyen, David Hiendat Hua

    2011-01-01

    2009). Triple-Negative Breast Cancer: Distinguishing betweenreceptor-negative breast cancer patients. J Clin Invest 120,sporadic basal-like breast cancer. Oncogene 26, 2126-2132.

  15. Diffusion MRI Methods for Improved Treatment Monitoring in Breast Cancer

    E-Print Network [OSTI]

    Aliu, Sheye

    2009-01-01

    Breast Cancer Overview 2.1 Breast Anatomy . . . . .2.2 Breast Cancer Demographics . . . . . . . . 2.3 Breastii References Diffusion Tensor Imaging in Breast Cancer 5.1

  16. Breast Cancer and Melanoma in the Same Pedigree

    E-Print Network [OSTI]

    Seltzer, Murray H; Leachman, Sancy A

    2008-01-01

    6 [ PubMed ] 11. The Breast Cancer Linkage Consortium. (of ocular melanoma with breast cancer but not with cutaneousin women with previous breast cancer. Journal of Clinical

  17. Serum 25-hydroxyvitamin D and risk of breast cancer

    E-Print Network [OSTI]

    Mohr, Sharif Burgette

    2012-01-01

    and prevention of breast cancer: pooled analysis. Anticancerand reduced risk of breast cancer: a population-based case-between vitamin D and breast cancer incidence and natural

  18. Cancer prevention for global health: a report from the ASPO International Cancer Prevention Interest Group.

    E-Print Network [OSTI]

    Braithwaite, Dejana; Boffetta, Paolo; Rebbeck, Timothy R; Meyskens, Frank

    2012-01-01

    Bull 14. WHO. International Agency for Research on Cancer:World Cancer Report. In Stuart BW, Kleihues P, editors.of environmental and occupational cancer. Oncogene 2004;23:

  19. Protein engineering for cancer therapy

    E-Print Network [OSTI]

    Liu, David Victor

    2012-01-01

    The immunosuppressive effects of CD4?CD25? regulatory T cells (Tregs) interfere with anti-tumor immune responses in cancer patients. In the first part of this work, we present a novel class of engineered Interleukin-2 ...

  20. Chromatin organisation in breast cancer

    E-Print Network [OSTI]

    Rafique, Sehrish

    2013-11-29

    Epigenetic misregulation of gene expression is known to be an important feature in cancer. This has mainly been studied at the level of changes in DNA methylation and histone modifications at individual genes. In this ...

  1. Fusion genes in breast cancer

    E-Print Network [OSTI]

    Batty, Elizabeth

    2012-02-07

    Fusion genes in breast cancer Elizabeth M. Batty Clare College, University of Cambridge A dissertation submitted to the University of Cambridge in candidature for the degree of Doctor of Philosophy November 2010 ii... is the outcome of work done in collaboration except where specifically indicated in the text. It has not been submitted whole or in part for any other qualification at any other University. iii Summary Fusion genes in breast cancer Elizabeth Batty...

  2. The effect of gender on Helicobacter pylori and gastric cancer

    E-Print Network [OSTI]

    Sheh, Alexander

    2011-01-01

    Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium ...

  3. Serum 25-hydroxyvitamin D and risk of breast cancer

    E-Print Network [OSTI]

    Mohr, Sharif Burgette

    2012-01-01

    and prevention of breast cancer: pooled analysis. AnticancerBray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA-Cancer J Clin. 2005;55(2):74-108. American Cancer

  4. An analytics approach to designing clinical trials for cancer

    E-Print Network [OSTI]

    Relyea, Stephen L. (Stephen Lawrence)

    2013-01-01

    Since chemotherapy began as a treatment for cancer in the 1940s, cancer drug development has become a multi-billion dollar industry. Combination chemotherapy remains the leading treatment for advanced cancers, and cancer ...

  5. Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer

    E-Print Network [OSTI]

    Greenaway, Alan

    Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer Graeme Houston Fluoroscopy 2 #12;Treatments for Cancer Palliative Relief of obstruction Reduce Bleeding Pain Control Avoid complications Disease Modifying 4 #12;Disease Modifying Cancer Treatment In Situ Ablation

  6. Communication and Cancer Suggestions for Navigating Relationships

    E-Print Network [OSTI]

    Brent, Roger

    Communication and Cancer Suggestions for Navigating Relationships During and After Cancer Moving Increased attention to the effect of communication Increased awareness of communication styles Introduction to theories about communication Consider communication patterns in relationships Resources

  7. Genetics and molecular biology of breast cancer

    SciTech Connect (OSTI)

    King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

    1992-12-31

    This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

  8. Targeting cancer metabolism: a therapeutic window opens

    E-Print Network [OSTI]

    Vander Heiden, Matthew G.

    Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

  9. ANTI-CANCER NANOPARTICLE SYNTHESIS AND CHARACTERIZATION

    E-Print Network [OSTI]

    ANTI-CANCER NANOPARTICLE SYNTHESIS AND CHARACTERIZATION Fan Mei1 , Da-Ren Chen2 and Yin-Nan Lee1 1, (-)-epigallocatechin-3-gallate (EGCG) from Green tea, Irresa and resveratrol have been shown to exhibit cancer

  10. Lgr4 in Breast Cancer Stem Cells

    E-Print Network [OSTI]

    Zeng, Li

    2014-12-11

    Breast cancer is the most commonly diagnosed cancer among American women. G-protein coupled receptors (GPCR) comprise a huge family protein with almost 800 members. GPCRs sense molecules or other stimuli outside the cell, and activate intracellular...

  11. Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

    SciTech Connect (OSTI)

    Boukheris, Houda; Stovall, Marilyn; Gilbert, Ethel S.; Stratton, Kayla L.; Smith, Susan A.; Weathers, Rita; Hammond, Sue; Mertens, Ann C.; Donaldson, Sarah S.; Armstrong, Gregory T.; Robison, Leslie L.; Neglia, Joseph P.; Inskip, Peter D.

    2013-03-01

    Purpose: To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials: Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results: During the time period of the study, 23 cases of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion: Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies.

  12. Identifying Risk Groups Associated with Colorectal Cancer

    E-Print Network [OSTI]

    Jin, Huidong "Warren"

    Identifying Risk Groups Associated with Colorectal Cancer Jie Chen1 , Hongxing He1 , Huidong Jin1 of identifying and describing risk groups for colorectal cancer (CRC) from population based administrative health are applied to the colorectal cancer patients' profiles in contrast to background pa- tients' profiles

  13. www.yalecancercenter.org Lung Cancer Screening

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Lung Cancer Screening Guest Experts: Lynn Tanoue, MD Professor of Therapeutic Radiology and an expert in the use of radiation to treat lung cancers and cutaneous lymphomas Oncology Program. Dr. Detterbeck and I also co- direct the new Yale Lung Cancer and Lung Nodule Screening

  14. www.yalecancercenter.org Lung Cancer Awareness

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Lung Cancer Awareness Month Update Guest Expert: Frank Detterbeck, MD take a look at the prevention and treatment of lung cancer with Dr. Frank Detterbeck, Professor I want to start out with a question about cigarette smoking and lung cancer. Obviously

  15. www.yalecancercenter.org Lung Cancer Awareness

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Lung Cancer Awareness Month Update 2008 Guest Expert: Frank Detterbeck, MD reach the end of lung cancer awareness month, Ed and Ken welcome the Directors of the Yale Cancer Center of thoracic surgery at Yale and Dr. Tanoue is a Professor of pulmonary medicine. Tanoue Unfortunately, lung

  16. www.yalecancercenter.org Understanding Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Understanding Lung Cancer Guest Expert: Daniel Morgensztern, MD www of radiation to treat lung cancer and cutaneous lymphomas. If you would like to join the conversation, you can at the Yale School of Medicine and he specializes in the treatment and care of patients with lung cancer. Here

  17. Birgit Arb, MD Cape Fear Cancer

    E-Print Network [OSTI]

    Olszewski Jr., Edward A.

    Birgit Arb, MD Cape Fear Cancer Specialists Women of Hope is a charitable organization dedicated to enhancing the quality of life for the female cancer patient, their families, and friends. They provide through any type of cancer from diagnosis through survivorship. Women of Hope 1642 South 41st Street

  18. Breast Cancer Research Finding Answers. Finding Cures.

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

  19. LITERATURE REVIEW Autism and Cancer Risk

    E-Print Network [OSTI]

    Crespi, Bernard J.

    LITERATURE REVIEW Autism and Cancer Risk B. Crespi A literature review was conducted on the genetic and developmental bases of autism in relation to genes and pathways associated with cancer risk. Convergent lines cancer-associated genes and pathways, and (4) contrasts with schizophrenia, Parkinson's, and Alzheimer

  20. Breast Cancer Awareness Day October 7, 2009

    E-Print Network [OSTI]

    Kihara, Daisuke

    Breast Cancer Awareness Day October 7, 2009 All are welcome to the different events organized by the Purdue Breast Cancer Discovery Group. Sigma Xi Distinguished Lecture "Genes and the microenvironment: the two faces of breast cancer" Deans Auditorium (PFEN241) Pfendler Hall Purdue University 12

  1. This issue of the Stanford Cancer Institute Clinical Research Newsletter is focused on our multi-disciplinary Women's Cancer and Urologic Cancer Programs.

    E-Print Network [OSTI]

    Puglisi, Joseph

    This issue of the Stanford Cancer Institute Clinical Research Newsletter is focused on our multi-disciplinary Women's Cancer and Urologic Cancer Programs. Both programs provide comprehensive cancer services, employ, including targeted therapies and vaccines. The new Stanford Women's Cancer Center opened on June 27, 2011

  2. SKIN CANCER INSTITUTE THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE

    E-Print Network [OSTI]

    Chisholm, Rex L.

    of specimens with unclear diagnoses sent from throughout the United States. Our pathologists are thus some than 75 percent of skin cancer deaths. It is now estimated that one in every 55 people will be diagnosed with melanoma. The incidence also is rising at a rate faster than that of the seven most common

  3. Interim Action Determination

    Broader source: Energy.gov (indexed) [DOE]

    and uranium stored in vaults for vitrification in DWPF would result in 0.07 latent cancer fatalities (or, zero) in the offsite population, and 0.11 latent cancer fatalities...

  4. Colorectal Cancer Video for the Deaf Community: A Randomized Control Trial

    E-Print Network [OSTI]

    Shabaik, Salma; LaHousse, Sheila F.; Branz, Patricia; Gandhi, Visha; Khan, Amir M.; Sadler, Georgia Robins

    2010-01-01

    cantly more colorectal cancer knowledge than the controlthe Deaf community about colorectal cancer. KeywordsASL . Cancer prevention . Colorectal cancer . Deaf .

  5. The path to personalized medicine in women?s cancers: challenges and recent advances

    E-Print Network [OSTI]

    Konecny, GE

    2015-01-01

    staging system for ovarian cancer: what is new in comparisontarget tumor vasculature in ovarian cancer. Curr Opin Obstetbreast cancer and ovarian cancer therapy. Curr Opin Obstet

  6. The path to personalized medicine in women cancers: Challenges and recent advances

    E-Print Network [OSTI]

    Konecny, GE

    2015-01-01

    staging system for ovarian cancer: what is new in comparisontarget tumor vasculature in ovarian cancer. Curr Opin Obstetbreast cancer and ovarian cancer therapy. Curr Opin Obstet

  7. Chemotherapy of ovarian cancer directed by the human tumor stem cell assay.

    E-Print Network [OSTI]

    1981-01-01

    RC (1975) Chemotherapy of ovarian cancer: Past and present.treatment of advanced ovarian cancer. Cancer Treat Rep 63:for predicting response of ovarian cancer to chemotherapy.

  8. Bayesian Nonparametric Latent Feature Models

    E-Print Network [OSTI]

    Miller, Kurt Tadayuki

    2011-01-01

    Association, 96(455):1077 John Paisley and Lawrence Carin.learning (ICML), John Paisley, Aimee Zaas, Christopher W.work was later mirrored by Paisley and Carin (2009), whose

  9. DIESEL et CANCER Dominique Lafon

    E-Print Network [OSTI]

    Boyer, Edmond

    1/5 DIESEL et CANCER Dominique Lafon INERIS (*) De nombreuses questions se posent sur la toxicit des missions des moteurs diesel. C'est un sujet qui a beaucoup proccup les scientifiques ces EMISSIONS DU DIESEL. Avant d'aborder la toxicit des missions du diesel, un rappel de leur composition est

  10. Do Cell Phones Cause Cancer?

    E-Print Network [OSTI]

    Leikind, Bernard

    2010-01-01

    Do cell phones, household electrical power wiring or appliance, or high voltage power lines cause cancer? Fuggedaboudit! No way! When pigs fly! When I'm the Pope! Don't text while you're driving, however, or eat your cell phone. All organisms absorb microwave radiation directly as thermal energy. In living organisms, the organisms' thermal control systems, including the blood flow, and various cooling mechanisms, such as sweating in humans, that work to maintain a stable body temperature rapidly transfer the absorbed energy to the environment. Any temperature rise is small or even unobserved. Any proposed mechanism by which cell phone radiation might cause cancer must begin with this fact. But the amount of radiation absorbed from a cell phone is less than that produced by normal metabolic processes, and much less than that produced by, for example, exercise. None of these normal metabolic processes cause cancer. Therefore, the much smaller amounts of energy from cell phones doesn't cause cancer either. All f...

  11. Pancreatic cancer: Pathogenesis, prevention and treatment

    SciTech Connect (OSTI)

    Sarkar, Fazlul H. Banerjee, Sanjeev; Li, Yiwei

    2007-11-01

    Pancreatic cancer is the fourth leading cause of cancer death in the United States with a very low survival rate of 5 years. To better design new preventive and/or therapeutic strategies for the fight against pancreatic cancer, the knowledge of the pathogenesis of pancreatic cancer at the molecular level is very important. It has been known that the development and the progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes, and the deregulation of many signaling pathways among which the EGFR, Akt, and NF-{kappa}B pathways appear to be most relevant. Therefore, the strategies targeting EGFR, Akt, NF-{kappa}B, and their downstream signaling could be promising for the prevention and/or treatment of pancreatic cancer. In this brief review, we will summarize the current knowledge regarding the pathogenesis, prevention, and treatment of pancreatic cancer.

  12. Predictive and therapeutic markers in ovarian cancer

    DOE Patents [OSTI]

    Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; Fridlyand, Jane; Mills, Gordon B.

    2013-03-26

    Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

  13. Anti-cancer Technology Summary 121 Research Drive, Suite 501

    E-Print Network [OSTI]

    Peak, Derek

    Anti-cancer Technology Summary 121 Research Drive, Suite 501 Saskatoon, SK, S7N 1K2 Tel: (306) 966 cancers are ranked 2ed , 3ed and 11th of the most diagnosed cancers (National Cancer Institute, USA cancer cells but also healthy ones. A great opportunity exists for targeted therapies for the use solely

  14. Cancer Research in Botswana Surbhi Grover, MD MPH

    E-Print Network [OSTI]

    Bushman, Frederic

    Cancer Research in Botswana Surbhi Grover, MD MPH Assistant Professor, Radiation Oncology, UPENN and are developing cancers and other NCDs #12;3 HIV and Cancer wHIV infection increases the risk of cancer wIn the later stages of HIV infection, chronic immunosuppression (& other co-factors) leads to cancer formation

  15. PrincetonUniversity In-Vitro Studies of Cancer

    E-Print Network [OSTI]

    Petta, Jason

    PrincetonUniversity In-Vitro Studies of Cancer Cell Death Due to Hyperthermia C. Barkey1, RUniversity Cancer: Facts and Figures World Wide 10.1 million newly diagnoses/year with ~10% increase 6.2 million deaths are attributed to cancer and its complication each year American Cancer Society 2007 and Le Cancer

  16. Selective pressures for and against genetic instability in cancer

    E-Print Network [OSTI]

    Wan, Frederic Yui-Ming

    Selective pressures for and against genetic instability in cancer: a time-dependent problem Natalia instability in cancer is a two-edge sword. It can both increase the rate of cancer progression (by increasing the probability of cancerous mutations) and decrease the rate of cancer growth (by imposing a large death toll

  17. High Throughput Analysis of Breast Cancer Specimens on the Grid

    E-Print Network [OSTI]

    cancer accounts for about 30% of all cancers and 15% of all cancer deaths in women in the United States in the United States. Women living in North America have the highest rate of breast cancer in the world [1]. In spite of the increase in the incidence of the disease, the death rates of breast cancer continue

  18. Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam

    E-Print Network [OSTI]

    Petta, Jason

    Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam PresentedPresentation Overview What is Synthetic Biology?What is Synthetic Biology? ProjectProject Cancer: Detect and DestroyCancer regeneration Diabetes Cancer therapy Artificial immune system Environmental Biosensing Environmental

  19. Global modeling of cancer gene expression signa-Cancer leads to permanent changes in cell's physiological state and various

    E-Print Network [OSTI]

    Kaski, Samuel

    Global modeling of cancer gene expression signa- tures Cancer leads to permanent changes in cell cancer types. Less is known about the underlying biological processes, or relationships between different cancer types with respect to these changes. While each specific cancer type has a set of unique

  20. Genome Science and Personalized Cancer Treatment

    ScienceCinema (OSTI)

    Gray, Joe

    2010-01-08

    August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  1. Genome Science and Personalized Cancer Treatment

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-07

    August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks particularly with regard to breast cancer.

  2. Genome Science and Personalized Cancer Treatment

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-04

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks particularly with regard to breast cancer.

  3. Perspectives on the mesenchymal origin of metastatic cancer

    E-Print Network [OSTI]

    Huysentruyt, Leanne C.; Seyfried, Thomas N.

    2010-01-01

    of metastasis. Nature Reviews Cancer, 9(4), 239252. 12.M. , & Kovarik, J. (1987). Is cancer a macrophage- mediatedof secondary growths in cancer of the breast. Lancet, 1,

  4. Nanomaterials for the detection of cancer-associated biomarkers

    E-Print Network [OSTI]

    Mu, Chunyao Jenny

    2010-01-01

    Prostate cancer persists as a major public health issue in the United States and remains the second leading cause of cancer death in men. Early detection and disease monitoring in prostate cancer can significantly improve ...

  5. Microwave imaging for ultra-wideband antenna based cancer detection

    E-Print Network [OSTI]

    Zhang, Haoyu

    2015-06-29

    Breast cancer is one of the most widespread types of cancer in the world. The key factor in treatment is to reliably diagnose the cancer in the early stages. Moreover, currently used clinical diagnostic methods, such as ...

  6. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print Tuesday, 23 June 2015 13:00 The cancer drug...

  7. The genomic complexity of primary human prostate cancer

    E-Print Network [OSTI]

    Carter, Scott L.

    Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence ...

  8. Analysis of Assembly Bill 547: Ovarian Cancer Screening

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2004-01-01

    al. (1999). Screening for ovarian cancer: a pilot randomizedLung, Colorectal & Ovarian Cancer Screening Trial ( P L CA Snapshot of Ovarian Cancer. http://prg.nci.nih.gov/

  9. Cell Motility and Deformability in the Pathogenesis of Lung Cancer

    E-Print Network [OSTI]

    Pagano, Paul Carmelo

    2015-01-01

    metastatic potential of ovarian cancer cells. PLoS One 2012;cisplatin resistance in ovarian cancer cells. Nanomedicine :metastatic potential of ovarian cancer cells. PLoS One 2012;

  10. Cutaneous cancers in Calabar, Southern Nigeria

    E-Print Network [OSTI]

    Asuquo, Maurice E; Ebughe, Godwin

    2009-01-01

    Skin cancer in Zaria, Nigeria. Trop Doct 1995; 25(Suppl. ):Malignancies in Kano, Northern Nigeria: A histopathologicalequatorial rain forest of Nigeria. International Journal of

  11. Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group

    E-Print Network [OSTI]

    2009-01-01

    quality of life among long-term survivors of breast cancer.Breast Cancer Res Treat. 1996;39(3):26173. doi:B, Bower JE. Breast Cancer in Younger Women: Reproductive

  12. Polymorphisms in Stromal Genes and Susceptibility to Serous Epithelial Ovarian Cancer: A Report from the Ovarian Cancer Association Consortium

    E-Print Network [OSTI]

    2011-01-01

    and serous epithelial ovarian cancer stratified by case PLoSLumican SNPs and Serous Ovarian Cancer References 1. JemalEpidemiology and etiology of ovarian cancer. Semin Oncol 18:

  13. Breast cancer is a common form of cancer among women. Mammography is used for early detection, but it cannot detect all instances of cancer. New magnetic resonance imaging

    E-Print Network [OSTI]

    Subramanian, Kalpathi R.

    1 Breast cancer is a common form of cancer among women. Mammography is used for early detection by Stanford University and used at Presbyterian Hospital have detected breast cancer where mammography has possible to render MR data in 3D at interactive rates. This paper presents the design of breast cancer

  14. Nanotechnology in Cancer Treatment and Detection Richard Acosta

    E-Print Network [OSTI]

    Fygenson, Deborah Kuchnir

    Nanotechnology in Cancer Treatment and Detection Richard Acosta #12;Motivation Ineffectiveness or roughly 100 times smaller than most human cells Cancer Nanotechnology research is interdisciplinary

  15. Los Alamos researcher pens prizewinning essay on cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Researcher pens prizewinning essay on cancer Los Alamos researcher pens prizewinning essay on cancer Ludmil Alexandrov made strong points this week in the journal Science winning a...

  16. Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Print Wednesday, 03 December 2014 00:00 Immortality is...

  17. Isotope production facility produces cancer-fighting actinium

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer therapy gets a boost from new isotope Isotope production facility produces cancer-fighting actinium A new medical isotope project shows promise for rapidly producing major...

  18. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Review Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer Cancer Center, University of California, Davis, CA 95616, United States b Department of Food Science

  19. The Viability of Cancerous vs. Non-cancerous Cells

    E-Print Network [OSTI]

    Nickels, Logan

    2009-10-01

    is to use a cell-based assay to inject the compounds into the cells, and then measure the cells growth. To find the effects the compounds had on the cells, we needed some way to visualize the viability of the cell lines. To do this, we used... before the actual assay was a toxicity screen. The compounds used in the screen were stored in 384-well polypropylene plates. The plates contained 20 l of compound Figure 2. This graph shows the growth curve of the cancerous A-549 cells, which have...

  20. Early Growth Response 3 (Egr3) Is Highly Over-Expressed in Non-Relapsing Prostate Cancer but Not in Relapsing Prostate Cancer

    E-Print Network [OSTI]

    Pio, Rebecca; Jia, Zhenyu; Baron, Veronique T; Mercola, Dan; Agoulnik, Irina U

    2013-01-01

    company developing prostate cancer related tests. Dr. Barontherapy for prostate cancer. There are no marketed productsand prognosis of prostate cancer. September 2011: US

  1. Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

    E-Print Network [OSTI]

    2012-01-01

    Familial Breast and Ovarian Cancer and Center of IntegratedAustralia, 66 Australian Ovarian Cancer Study [AOCS], PeterHereditary Breast & Ovarian Cancer (GC-HBOC) was supported

  2. Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility ??Hot-Spot?

    E-Print Network [OSTI]

    2010-01-01

    and susceptibility to serous ovarian cancer in three studygenetic risk associations for ovarian cancer throughthe international Ovarian Cancer Association Consortium. Br

  3. Development of a Breast Cancer Stem Cell Model and the Inhibitory Regulation of Small Molecule Phytochemicals on Various Stages of Human Breast Cancer Cells

    E-Print Network [OSTI]

    Tin, Antony Shen

    2013-01-01

    stem cells in breast cancer and metastasis. Breast cancer research and treatment 118(2):241-?Birnbaum D (2009) Breast cancer stem cells: tools

  4. Bacon butty cancer risk ONLINE REPORTER

    E-Print Network [OSTI]

    Lega, Joceline

    Bacon butty cancer risk ONLINE REPORTER Published: 31st October 2007 0 PROCESSED meats, including ham and bacon are such a high risk factor for bowel cancer they should be avoided completely, bacon, pastrami, salami, and frankfurters. However, not all minced meats and hamburgers were considered

  5. Cancer Stem Cells: Models and Concepts

    E-Print Network [OSTI]

    Brutlag, Doug

    Cancer Stem Cells: Models and Concepts Piero Dalerba, Robert W. Cho, and Michael F. Clarke Stanford c 2007 by Annual Reviews. All rights reserved 0066-4219/07/0218-0267$20.00 Key Words self-renewal by a pathologi- cal counterpart of normal adult stem cells, cancer stem cells. This model, first developed

  6. Diet and Cancer Are Cooked Meats Involved

    ScienceCinema (OSTI)

    LLNL - University of California Television

    2009-09-01

    Diet has been associated with differences in cancer rates in human populations for many years. Mark Knize presents the latest research on cancer causes including work performed at Lawrence Livermore National Laboratory investigating some interesting chemical products created when meat is cooked and how to reduce them. Series: Science on Saturday [10/2006] [Health and Medicine] [Science] [Show ID: 11542

  7. Clinical and experimental pathology of lung cancer

    SciTech Connect (OSTI)

    McVie, J.G.; Bakker, W.; Wagenaar, S.C.; Carney, D.

    1986-01-01

    This book contains 17 selections. Some of the titles are: Flow cytometric DNA analysis in the study of small cell carcinoma of the lung; Mechanisms of oncogenesis; Adhesion mechanisms in liver metastasis; Current concepts in the therapy of small cell lung cancer; Application of monoclonal antibodies in imaging and therapy; and Clinical applications of the biologic properties of small cell lung cancer.

  8. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

    1998-01-01

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

  9. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, M.J.; Weaver, V.M.

    1998-12-08

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying {beta}{sub 1} integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive. 14 figs.

  10. How much do cancer-related symptoms contribute to health-related quality of life in lung and colorectal cancer patients? A report from the Cancer Care Outcomes Research and Surveillance (CanCORS) Consortium.

    E-Print Network [OSTI]

    2015-01-01

    Cancer Societys studies of cancer survivors. Can- cer.palliative care provider. Cancer J. 2013;19: 31. Catalanoof par- ticipants in the Cancer Care Outcomes Research and

  11. Identification of Genomic Predictors of Response to the CDK4/6 Inhibitor Palbociclib using the UCLATORL Panel of Human Cancer Cell Lines

    E-Print Network [OSTI]

    Conklin, Dylan Francis

    2013-01-01

    invasive epithelial ovarian cancer. Cancer treatment reviewsto breast and ovarian cancer. European journal of cancer 42,locus in advanced human ovarian-cancer. Int J Oncol 6, 129-

  12. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three US population-based case-control studies of ovarian cancer

    SciTech Connect (OSTI)

    Whittemore, A.S.; Gong, G.; Itnyre, J.

    1997-03-01

    We investigate the familial risks of cancers of the breast and ovary, using data pooled from three population-based case-control studies of ovarian cancer that were conducted in the United States. We base estimates of the frequency of mutations of BRCA1 (and possibly other genes) on the reported occurrence of breast cancer and ovarian cancer in the mothers and sisters of 922 women with incident ovarian cancer (cases) and in 922 women with no history of ovarian cancer (controls). Segregation analysis and goodness-of-fit testing of genetic models suggest that rare mutations (frequency .0014; 95% confidence interval .0002-.011) account for all the observed aggregation of breast cancer and ovarian cancer in these families. The estimated risk of breast cancer by age 80 years is 73.5% in mutation carriers and 6.8% in noncarriers. The corresponding estimates for ovarian cancer are 27.8% in carriers and 1.8% in noncarriers. For cancer risk in carriers, these estimates are lower than those obtained from families selected for high cancer prevalence. The estimated proportion of all U.S. cancer diagnoses, by age 80 years, that are due to germ-line BRCA1 mutations is 3.0% for breast cancer and 4.4% for ovarian cancer. Aggregation of breast cancer and ovarian cancer was less evident in the families of 169 cases with borderline ovarian cancers than in the families of cases with invasive cancers. Familial aggregation did not differ by the ethnicity of the probands, although the number of non-White and Hispanic cases (N = 99) was sparse. 14 refs., 3 figs., 6 tabs.

  13. INCITE Seeking Proposals to Advance Science and Engineering at...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the LCF systems or require the unique LCF architectural infrastructure for high-performance computing projects that cannot be performed anywhere else. Proposals may be for up to...

  14. The Role of the Tumor Microenvironment and Epithelial-Mesenchymal Plasticity in Prostate Cancer Progression and Metastasis

    E-Print Network [OSTI]

    Ruscetti, Marcus Andrew

    2015-01-01

    in patients with castration-resistant prostate cancer.Cancer chemotherapy and pharmacology. 2010;66:181-9.in metastatic breast cancer. British journal of cancer.

  15. Polymorphisms of the Hypoxia Inducible Factor 1 and microRNA Related Genes and the Susceptibility and Survival of Lung Cancer and Upper Aero-Digestive Tract Cancers

    E-Print Network [OSTI]

    YANG, YING

    2014-01-01

    1 I. Lung and upper aero-digestive tractof Lung Cancer and Upper Aero-Digestive Tract Cancers Aof Lung Cancer and Upper Aero-Digestive Tract Cancers by

  16. Predicting Cancer-Specific Vulnerability via Data-Driven

    E-Print Network [OSTI]

    Ruppin, Eytan

    Resource Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic LethalityCancer Research UK, The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, Scotland the inhibition of each single gene is not. It can be harnessed to selectively treat cancer by identifying

  17. www.yalecancercenter.org Lung Cancer Awareness 2009

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Lung Cancer Awareness 2009 Guest Expert: Thomas Lynch, Jr., MD Director of lung cancer. Chu What got you interested in focusing your career on the treatment of lung cancer? Lynch I actually got into lung cancer sort of by serendipity. I wish I could tell you that it was a well

  18. Study for Advanced Lung Cancer Patients Guest Expert

    E-Print Network [OSTI]

    O'Hern, Corey S.

    Study for Advanced Lung Cancer Patients Guest Expert: Roy S. Herbst, MD, PhD Ensign Professor message at 888-234-4YCC. This week you will hear a conversation about clinical trials for advanced lung of lung caner at Yale Cancer Center and Smilow Cancer Hospital? Herbst As you probably know, lung cancer

  19. www.yalecancercenter.org An Update on Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org An Update on Lung Cancer Guest Expert: Roy Decker, MD, PhD Assistant the detection and treatment of lung cancer with Dr. Scott Gettinger and Dr. Roy Decker. Chu Scott, let us start off by telling our listeners what lung cancer is and how common it is. Gettinger Lung cancer

  20. AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention

    E-Print Network [OSTI]

    Kaski, Samuel

    AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention What are the chances that I will develop lung cancer? The #1 cause of lung cancer is exposure to tobacco smoke. Your chances increase others (second-hand smoke), the greater your chances of developing lung cancer. People who have never

  1. Cancer and the Golub Paper BINF702 WEEK 1 1

    E-Print Network [OSTI]

    Solka, Jeff

    1/2/2015 1 Cancer and the Golub Paper BINF702 WEEK 1 1 Cancer Known medically as a malignant uncontrollably, forming a tumor Not all tumors are cancerous; benign tumors do not invade neighboring tissues is the spread of a malignant cancer to more distant parts of the body through the lymphatic system

  2. Cancer Prevention in Eastern North Carolina Task 3: Final Report

    E-Print Network [OSTI]

    Gopalakrishnan, K.

    1 Cancer Prevention in Eastern North Carolina Task 3: Final Report A Cancer Profile of Eastern, MPA Interim Manager, NC Comprehensive Cancer Program North Carolina Department of Health and Human University Greenville, NC 27834 Contract # 02776-12 #12;2 Project Title: Cancer Prevention in Eastern North

  3. When life hurts, writing can help... Writing Through Cancer

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    When life hurts, writing can help... Writing Through Cancer An expressive writing program for people living with cancer Led by Sharon Bray, Ed.D. NEW SERIES BEGINS FRIDAY, FEBRUARY 13, 2015 10 weeks of other cancer patients and survivors. We meet each week to explore and share our stories of the cancer

  4. Cancer Cells DOI: 10.1002/anie.201103189

    E-Print Network [OSTI]

    Zhang, Liangfang

    Cancer Cells DOI: 10.1002/anie.201103189 Self-Propelled Microrockets to Capture and Isolate Circulating Tumor Cells Weiwei Gao and Omid C. Farokhzad* cancer micromachines nanorobots nanotechnology metastatic cancer.[1] Since then cancer research has proved the critical roles played by CTC

  5. Eighth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer

    E-Print Network [OSTI]

    Ronquist, Fredrik

    Eighth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer Supplement to Cancer- therapy of Cancer, Princeton, New Jersey, October 1214, 2000. Supported by grant no. 1387 from the Swedish Cancer Research Council; the Lions Foundation in Ume, Sweden; the University of Ume, Sweden

  6. Buccal Spectral Markers for Lung Cancer Risk Stratification

    E-Print Network [OSTI]

    Hartline, Jason D.

    Buccal Spectral Markers for Lung Cancer Risk Stratification Andrew J. Radosevich1 *, Nikhil N, United States of America Abstract Lung cancer remains the leading cause of cancer deaths in the US with .150,000 deaths per year. In order to more effectively reduce lung cancer mortality, more sophisticated

  7. Using Near-Infrared Light To Detect Breast Cancer

    E-Print Network [OSTI]

    Fantini, Sergio

    Using Near-Infrared Light To Detect Breast Cancer Using Near-Infrared Light To Detect Breast Cancer News 25 T he idea of using light to non- invasively detect breast cancer has been revisited in the past of selectively labeling breast tumors may open new opportunities in the optical detection of breast cancer

  8. Breast Cancer: Modelling and Detection D.J. GAVAGHANa

    E-Print Network [OSTI]

    Maini, Philip K.

    Breast Cancer: Modelling and Detection D.J. GAVAGHANa , J.M. BRADYb , C.P. BEHRENBRUCHb , R cancer, breast carcinoma, to illustrate how the modelling can be used in aiding detection. We to meet some of the major challenges in cancer detection. Keywords: Breast cancer; Tumour; Image

  9. Estrogen receptor prevents p53-dependent apoptosis in breast cancer

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    Estrogen receptor prevents p53-dependent apoptosis in breast cancer Shannon T. Baileya,b,c,1) More than two-thirds of breast cancers express the estrogen receptor (ER) and depend on estrogen in the treatment of ER+ breast cancers of all stages. In contrast to ER- breast cancers, which frequently harbor

  10. Breast Cancer Research and ISSN 0167-6806

    E-Print Network [OSTI]

    1 23 Breast Cancer Research and Treatment ISSN 0167-6806 Breast Cancer Res Treat DOI 10.1007/s10549-012-2266-3 Cognitive function and breast cancer: promise and potential insights from functional brain imaging Patricia function and breast cancer: promise and potential insights from functional brain imaging Patricia A. Reuter

  11. Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal cell to a malignant one

    E-Print Network [OSTI]

    Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal regulators of growth. Biomarkers associated with cancer were examined in human breast epithelial cells transformed by high-LET radiation in the presence of 17-estradiol. An established cancer model was used

  12. Kidney cancer is one of the most common cancers occurring in 1-2% of individuals in their

    E-Print Network [OSTI]

    O'Hern, Corey S.

    Kidney cancer is one of the most common cancers occurring in 1-2% of individuals in their lifetime. The current incidence in the United States is approximately 60,000-cases/ year. While many cancers were believed to occur sporadically, it's now understood approximately 5-8% of kidney cancers have a genetic

  13. Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

    E-Print Network [OSTI]

    Wahl, Geoffrey M.

    Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Hospital for Sick Children, Toronto, Ontario, Canada; 4 Terry Fox Laboratory BC Cancer Research Center, Vancouver, British Columbia, Canada; 5 Moores University of California San Diego Cancer Center; 6 The Salk

  14. doi:10.1016/j.ijrobp.2006.02.044 INDUCED SECOND CANCERS AFTER PROSTATE-CANCER

    E-Print Network [OSTI]

    Brenner, David Jonathan

    doi:10.1016/j.ijrobp.2006.02.044 EDITORIAL INDUCED SECOND CANCERS AFTER PROSTATE-CANCER University Medical Center, New York, NY The absolute risks of a radiation-induced second cancer among long concern, expressed by Kendal et al. (5) in this issue, that prostate cancer patients may be unduly

  15. [CANCER RESEARCH 63, 71587166, November 1, 2003] The Gene Expression Response of Breast Cancer to Growth Regulators: Patterns

    E-Print Network [OSTI]

    Ringnr, Markus

    [CANCER RESEARCH 63, 71587166, November 1, 2003] The Gene Expression Response of Breast Cancer transcriptional effects elicited in MCF7, T-47D, and MDA-MB-436 breast cancer cell lines by nine regulators at the gene expression level of diverse regulators of breast cancer growth and links the behavior of breast

  16. Genetic heterogeneity of breast-ovarian cancer revisited

    SciTech Connect (OSTI)

    Narod, S.; Ford, D.; Easton, D.

    1995-10-01

    We have recently reported the results of a linkage analysis of 145 breast-ovarian cancer families. Each family has three or more cases of early-onset breast cancer (age {le}60) or of ovarian cancer, and all families have at least one case of ovarian cancer (there were nine site-specific ovarian cancer families). Overall, we estimated that 76% of the families were linked to the BRCA1 locus. 5 refs., 1 tab.

  17. Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

    E-Print Network [OSTI]

    Fendt, Sarah-Maria

    Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin; however, the mechanism by which metformin improves cancer ...

  18. Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts

    E-Print Network [OSTI]

    Kelly, KM; Dean, J; Comulada, WS; Lee, SJ

    2010-01-01

    at high risk for breast cancer with MR imaging. Breast Can-Findings from the Breast Cancer Surveillance Consortium:women undergoing biopsy after screening mammography. Cancer

  19. Analysis of Genomic Rearrangements in Cancer from High Throughput Sequencing Data

    E-Print Network [OSTI]

    Ballinger, Tracy Jean

    2015-01-01

    2.2 Cancer evolution . . . . . . . . . . . . . . . . . . . .5 Retrotransposition in cancer genomes 5.1 Retrotransposonrearrangements in cancer . . . . . . . . 2.3.2 Graph-based

  20. Estrogen withdrawal, increased breast cancer risk and the KRAS-variant

    E-Print Network [OSTI]

    2015-01-01

    estrogen signaling and Table 5. Second breast cancer risk inKRAS- variant breast cancer patients controlling for lobularand metachronous breast cancer when controlling for lobular

  1. Progression of endometriosis to cancer: too MUCh FoxP3+ regulatory T-cell response?

    E-Print Network [OSTI]

    Prieto, G. A

    2011-01-01

    glycosylated Mucin-1 in ovarian cancer. Histopathology 57,and endometrioid ovarian cancer. Nat. Med. 11, 63-70.T. and Konishi, I. (2009). Ovarian cancer in endometriosis:

  2. Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status

    E-Print Network [OSTI]

    2014-01-01

    OPEN SUBJECT AREAS: OVARIAN CANCER DISEASES Received 9Characteristics of Ovarian Cancer Classified by BRCA1,B. A. The genetics of ovarian cancer. Best Pract Res Clin

  3. Sociodemographic disparities in advanced ovarian cancer survival and adherence to treatment guidelines

    E-Print Network [OSTI]

    Bristow, RE; Chang, J; Ziogas, A; Campos, B; Chavez, LR; Anton-Culver, H

    2015-01-01

    women diagnosed with ovarian cancer in the United States. JOzols R, et al. NCCN Ovarian Cancer Practice Guidelines. Thepractice guidelines for ovarian cancer. Version 2000. Fort

  4. Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance

    E-Print Network [OSTI]

    2014-01-01

    ticellular spheroids in ovarian cancer metasta- ses: biologyNaora H, Montell DJ. Ovarian cancer metastasis: integratingpatients with primary ovarian cancer. J Surg Oncol. 2009; 6.

  5. Health anxiety and cognitive processes as risks for insomnia in women undergoing chemotherapy for breast cancer

    E-Print Network [OSTI]

    Rissling, Michelle Brosemer; Rissling, Michelle Brosemer

    2012-01-01

    symptom cluster in breast cancer patients is associated withFatigue and Sleep in Breast Cancer Patients Undergoingwomen with metastatic breast cancer. The breast journal, 8(

  6. Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

    E-Print Network [OSTI]

    Amin Al Olama, Ali; Benlloch, Sara; Antoniou, Antonis C.; Giles, Graham G.; Severi, Gianluca; Neal, David; Hamdy, Freddie C.; Donovan, Jenny L.; Muir, Kenneth; Schleutker, Johanna; Henderson, Brian E.; Haiman, Christopher; Schumacher, Fredrick R.; Pashayan, Nora; Pharoah, Paul D. P.; Ostrander, Elaine A.; Stanford, Janet L.; Batra, Jyotsna; Clements, Judith A.; Chambers, Suzanne K.; Weischer, Maren; Nordestgaard, Brge G.; Ingles, Sue Ann; Sorensen, Karina D.; Orntoft, Torben F.; Park, Jong Y.; Cybulski, Cezary; Maier, Christiane; Doerk, Thilo; Dickinson, Joanne L.; Cannon-Albright, Lisa; Brenner, Hermann; Rebbeck, Timothy R.; Zeigler-Johnson, Charnita; Habuchi, Tomonori; Thibodeau, Stephen N.; Cooney, Kathleen; Chappuis, Pierre O.; Hutter, Pierre; Kaneva, Radka P.; Foulkes, William D.; Zeegers, Maurice P.; Lu, Yong-Jie; Zhang, Hong-Wei; Stephenson, Robert; Cox, Angela; Southey, Melissa C.; Spurdle, Amanda B.; FitzGerald, Liesel; Leongamornlert, Daniel; Saunders, Edward; Tymrakiewicz, Malgorzata; Guy, Michelle; Dadaev, Tokhir; Little, Sarah J.; Govindasami, Koveela; Sawyer, Emma; Wilkinson, Rosemary; Herkommer, Kathleen; Hopper, John L.; Lophatonanon, Aritaya; Rinckleb, Antje E.; Kote-Jarai, Zsofia; Eeles, Rosalind A.; Easton, Douglas F.

    2015-04-02

    & Prevention.pdf.txt Content-Type text/plain; charset=UTF-8 1 Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci Ali Amin Al Olama1,56, Sara Benlloch1,56, Antonis C... @medschl.cam.ac.uk Tel: 0044 1223 748638 Fax: 0044 1223 748628 Running Title: Risk Analysis of Prostate Cancer in PRACTICAL Consortium Keywords: Prostate Cancer risk, Genetic and Molecular Epidemiology, Genitourinary Cancers: Prostate, Risk...

  7. Cancer-specific variation in emergency presentation by sex, age and deprivation across 27 common and rarer cancers

    E-Print Network [OSTI]

    Abel, G. A.; Shelton, J.; Johnson, S.; Elliss-Brookes, L.; Lyratzopoulos, G.

    2015-03-03

    logistic regression model that, conditional on being a cancer case, predicts the emergency presentation status (yes/no binary variable) adjusting for age, sex, deprivation group, year of diagnosis and cancer (model 1). Subsequently, we examined whether... age groups (laryngeal, melanoma, thyroid, oral, anal, brain, oropharynx, renal cancer and soft-tissue sarcoma). For one cancer (ALL), the reverse pattern was observed. For the remaining cancers (AML, colon, stomach, oesophageal, liver, bladder, Sex6 O...

  8. Engineering persistent interleukin-2 for cancer immunotherapy

    E-Print Network [OSTI]

    Gai, Shuning

    2012-01-01

    Mobilizing the immune system to recognize and destroy tumor cells is a promising strategy for treating cancer. In contrast to standard therapeutic approaches such as surgery, radiation, and chemotherapy, immunotherapy ...

  9. Stromal Endothelial Cells Directly Influence Cancer Progression

    E-Print Network [OSTI]

    Franses, Joseph Wang

    Cancer growth and metastasis are regulated in part by stromal cells such as fibroblasts and immune cells within the tumor microenvironment. Endothelial cells (ECs) are also ubiquitous within tumors because tumors are ...

  10. Cancer systems biology: a network modeling perspective

    E-Print Network [OSTI]

    Lauffenburger, Douglas A.

    Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell type and tissue origin but also as a disease involving dysregulation of multiple pathways governing fundamental cell processes such ...

  11. Regulation of apoptosis in human cancer cells

    E-Print Network [OSTI]

    Lloyd, S. Julie-Ann (Simone Julie-Ann)

    2005-01-01

    Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis ...

  12. Micro and nanotechnology for cancer treatment

    E-Print Network [OSTI]

    Ullal, Adeeti (Adeeti Vedantham)

    2013-01-01

    Cancer is responsible for over 7.6 million deaths worldwide; the majority of patients fail to respond to drugs or become resistant over time. In order to gain a better understanding of drug efficacy in patients, we developed ...

  13. Development of New Treatments for Prostate Cancer

    SciTech Connect (OSTI)

    DiPaola, R. S.; Abate-Shen, C.; Hait, W. N.

    2005-02-01

    The Dean and Betty Gallo Prostate Cancer Center (GPCC) was established with the goal of eradicating prostate cancer and improving the lives of men at risk for the disease through research, treatment, education and prevention. GPCC was founded in the memory of Dean Gallo, a beloved New Jersey Congressman who died tragically of prostate cancer diagnosed at an advanced stage. GPCC unites a team of outstanding researchers and clinicians who are committed to high-quality basic research, translation of innovative research to the clinic, exceptional patient care, and improving public education and awareness of prostate cancer. GPCC is a center of excellence of The Cancer Institute of New Jersey, which is the only NCI-designated comprehensive cancer center in the state. GPCC efforts are now integrated well as part of our Prostate Program at CINJ, in which Dr. Robert DiPaola and Dr. Cory Abate-Shen are co-leaders. The Prostate Program unites 19 investigators from 10 academic departments who have broad and complementary expertise in prostate cancer research. The overall goal and unifying theme is to elucidate basic mechanisms of prostate growth and oncogenesis, with the ultimate goal of promoting new and effective strategies for the eradication of prostate cancer. Members' wide range of research interests collectively optimize the chances of providing new insights into normal prostate biology and unraveling the molecular pathophysiology of prostate cancer. Cell culture and powerful animal models developed by program members recapitulate the various stages of prostate cancer progression, including prostatic intraepithelial neoplasia, adenocarcinoma, androgen-independence, invasion and metastases. These models promise to further strengthen an already robust program of investigator-initiated therapeutic clinical trials, including studies adopted by national cooperative groups. Efforts to translate laboratory results into clinical studies of early detection and chemoprevention are underway. The specific goals of this program are: (1) To investigate the molecular mechanisms underlying normal prostate growth and differentiation and elucidate the molecular mechanisms underlying prostate oncogenesis. (2) To build on fundamental knowledge to develop effective therapeutic approaches for the treatment of prostate cancer. (3) To improve the control of prostate cancer through early detection, chemoprevention, and outreach and education. This new disease-based program is structured to improve interdisciplinary interactions and translational results. Already, through the dynamic leadership of Drs. Cory Abate-Shen and Robert DiPaola, new investigators were attracted to the field, new collaborations engendered, and numerous investigator-initiated trials implemented. Progress in GPCC and the program overall has been outstanding. The Center has success in uniting investigators with broad and complementary expertise in prostate cancer research. The overall goal and unifying theme is to elucidate basic mechanisms of prostate growth and oncogenesis, with the ultimate goal of promoting new and effective strategies for the eradication of prostate cancer in patients and populations at risk. Members wide range of research interests collectively optimize the chances of providing new insights into normal prostate biology and unraveling the molecular pathophysiology of prostate cancer. Studies in cell culture and powerful animal models developed recapitulate the various stages of prostate cancer progression, including prostatic intraepithelial neoplasia, adenocarcinoma, androgen-independence, invasion and metastases. These models promise to further strengthen an already robust program of investigator-initiated therapeutic clinical trials, including studies adopted by national cooperative groups. Efforts to translate laboratory results into clinical studies of early detection and chemoprevention are underway.

  14. Focus on the Physics of Cancer

    E-Print Network [OSTI]

    Risler, Thomas

    2015-01-01

    Despite the spectacular achievements of molecular biology in the second half of the twentieth century and the crucial advances it permitted in cancer research, the fight against cancer has brought some disillusions. It is nowadays more and more apparent that getting a global picture of the very diverse and interlinked aspects of cancer development necessitates, in synergy with these achievements, other perspectives and investigating tools. In this undertaking, multidisciplinary approaches that include quantitative sciences in general and physics in particular play a crucial role. This `focus on' collection contains 19 articles representative of the diversity and state-of-the-art of the contributions that physics can bring to the field of cancer research.

  15. Cancer Cell Metabolism: One Hallmark, Many Faces

    E-Print Network [OSTI]

    Sabatini, David M.

    Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly ...

  16. Regulatory roles of endothelial cells in cancer

    E-Print Network [OSTI]

    Franses, Joseph W. (Joseph Wang)

    2011-01-01

    This thesis describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view ...

  17. Investigation into taxane resistant breast cancer

    E-Print Network [OSTI]

    Kenicer, Juliet Elisabeth Margaret

    2011-11-25

    One group of chemotherapeutics that are used successfully to treat breast cancer, alone or in combination with other agents, are the taxanes; paclitaxel and docetaxel. They act by interfering with the spindle microtubule ...

  18. Breast Density and Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Breast Cancer Awareness Series: Understanding Breast Density Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in...

  19. Photoswitchable nanoparticles for in vivo cancer chemotherapy

    E-Print Network [OSTI]

    Tong, Rong

    There are many obstacles to effective cancer chemotherapy, including drug penetration and accumulation in tumors and drug systemic toxicity. The penetration of therapies into tumors is limited by the dense tumor matrix and ...

  20. Somatic retrotransposition in the cancer genome

    E-Print Network [OSTI]

    Helman, Elena

    2014-01-01

    Cancer is a complex disease of the genome exhibiting myriad somatic mutations, from single nucleotide changes to various chromosomal rearrangements. The technological advances of next-generation sequencing enable high-throughput ...

  1. Mueller matrix imaging for skin cancer detection

    E-Print Network [OSTI]

    Baldwin, Angela Michelle

    2004-09-30

    is suspect, a biopsy is performed to verify the diagnosis. For squamous cell and basal cell carcinomas, the most common treatment options are excision, curettage and electrodesiccation, cryosurgery, radiation, and Moh?s micrographic surgery. Excision... is where all visible cancer is cut away together with a 3 to 10 mm margin of healthy tissue and then the skin is stitched closed with sutures. Curettage and electrodesiccation are where all visible cancer is scraped away and then an electric probe...

  2. Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer

    SciTech Connect (OSTI)

    Spellman, Paul T.; Heiser, Laura; Gray, Joe W.

    2009-06-18

    Breast cancer is predominantly a disease of the genome with cancers arising and progressing through accumulation of aberrations that alter the genome - by changing DNA sequence, copy number, and structure in ways that that contribute to diverse aspects of cancer pathophysiology. Classic examples of genomic events that contribute to breast cancer pathophysiology include inherited mutations in BRCA1, BRCA2, TP53, and CHK2 that contribute to the initiation of breast cancer, amplification of ERBB2 (formerly HER2) and mutations of elements of the PI3-kinase pathway that activate aspects of epidermal growth factor receptor (EGFR) signaling and deletion of CDKN2A/B that contributes to cell cycle deregulation and genome instability. It is now apparent that accumulation of these aberrations is a time-dependent process that accelerates with age. Although American women living to an age of 85 have a 1 in 8 chance of developing breast cancer, the incidence of cancer in women younger than 30 years is uncommon. This is consistent with a multistep cancer progression model whereby mutation and selection drive the tumor's development, analogous to traditional Darwinian evolution. In the case of cancer, the driving events are changes in sequence, copy number, and structure of DNA and alterations in chromatin structure or other epigenetic marks. Our understanding of the genetic, genomic, and epigenomic events that influence the development and progression of breast cancer is increasing at a remarkable rate through application of powerful analysis tools that enable genome-wide analysis of DNA sequence and structure, copy number, allelic loss, and epigenomic modification. Application of these techniques to elucidation of the nature and timing of these events is enriching our understanding of mechanisms that increase breast cancer susceptibility, enable tumor initiation and progression to metastatic disease, and determine therapeutic response or resistance. These studies also reveal the molecular differences between cancer and normal that may be exploited to therapeutic benefit or that provide targets for molecular assays that may enable early cancer detection, and predict individual disease progression or response to treatment. This chapter reviews current and future directions in genome analysis and summarizes studies that provide insights into breast cancer pathophysiology or that suggest strategies to improve breast cancer management.

  3. Radiation Dose and Subsequent Risk for Stomach Cancer in Long-term Survivors of Cervical Cancer

    SciTech Connect (OSTI)

    Kleinerman, Ruth A.; Smith, Susan A.; Holowaty, Eric; Hall, Per; Pukkala, Eero; Vaalavirta, Leila; Stovall, Marilyn; Weathers, Rita; Gilbert, Ethel; Aleman, Berthe M.P.; Kaijser, Magnus; Andersson, Michael; Storm, Hans; Joensuu, Heikki; Lynch, Charles F.; and others

    2013-08-01

    Purpose: To assess the doseresponse relationship for stomach cancer after radiation therapy for cervical cancer. Methods and Materials: We conducted a nested, matched casecontrol study of 201 cases and 378 controls among 53,547 5-year survivors of cervical cancer diagnosed from 1943 to 1995, from 5 international, population-based cancer registries. We estimated individual radiation doses to the site of the stomach cancer for all cases and to corresponding sites for the matched controls (overall mean stomach tumor dose, 2.56 Gy, range 0.03-46.1 and after parallel opposed pelvic fields, 1.63 Gy, range 0.12-6.3). Results: More than 90% of women received radiation therapy, mostly with external beam therapy in combination with brachytherapy. Stomach cancer risk was nonsignificantly increased (odds ratio 1.27-2.28) for women receiving between 0.5 and 4.9 Gy to the stomach cancer site and significantly increased at doses ?5 Gy (odds ratio 4.20, 95% confidence interval 1.41-13.4, P{sub trend}=.047) compared with nonirradiated women. A highly significant radiation doseresponse relationship was evident when analyses were restricted to the 131 cases (251 controls) whose stomach cancer was located in the middle and lower portions of the stomach (P{sub trend}=.003), whereas there was no indication of increasing risk with increasing dose for 30 cases (57 controls) whose cancer was located in the upper stomach (P{sub trend}=.23). Conclusions: Our findings show for the first time a significant linear doseresponse relationship for risk of stomach cancer in long-term survivors of cervical cancer.

  4. Cantilever MEMS Detection ofCantilever MEMS Detection of CancerCancer

    E-Print Network [OSTI]

    Petta, Jason

    Cantilever MEMS Detection ofCantilever MEMS Detection of CancerCancer O. Bravo, C. Milburn, W, NJ 08544 #12;OutlineOutline Introduction of bioMEMS AFM platform schematics Nanoindentations Vimentin antigen Graphs and data Clinical implications Future work #12;Introduction to BioMEMS Structure

  5. A filter-based feature selection approach for identifying potential biomarkers for lung cancer

    E-Print Network [OSTI]

    Lee, In-Hee; Lushington, Gerald H.; Visvanathan, Mahesh

    2011-03-21

    Background: Lung cancer is the leading cause of death from cancer in the world and its treatment is dependant on the type and stage of cancer detected in the patient. Molecular biomarkers that can characterize the cancer ...

  6. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01

    of lung cancer, Clinical Cancer Research, vol. 4, no. 7,pathogenesis of lung cancer, Annual Review of Physiology,immunoreac- tivity in lung cancer: yet another player in the

  7. An intraperitoneal implantable drug delivery device for the treatment of ovarian cancer

    E-Print Network [OSTI]

    Ye, Hongye

    2014-01-01

    Ovarian cancer is the fifth leading cause of cancer-related deaths in women and the deadliest gynecologic cancer. The current standard treatment for advanced ovarian cancer includes a minimally invasive cytoreduction ...

  8. Links Between Inflammation, Amygdala Reactivity, and Social Support in Breast Cancer Survivors.

    E-Print Network [OSTI]

    Muscatell, KA; Eisenberger, NI; Dutcher, JM; Cole, SW; Bower, JE

    2015-01-01

    women with advanced ovarian cancer. Cancer, 104, 305-313.outcomes of patients with ovarian cancer. J Clin Oncol, 30,killer cell activity in ovarian cancer. J Clin Oncol, 23,

  9. Vascular endothelial growth factor (VEGF) expression in locally advanced prostate cancer: secondary analysis of radiation therapy oncology group (RTOG) 8610

    E-Print Network [OSTI]

    2013-01-01

    of Radiation Oncology, Prince Edward Island Cancer Treatmentof Radiation Oncology, Prince Edward Island Cancer Treatment

  10. Online prediction of ovarian cancer

    E-Print Network [OSTI]

    Zhdanov, Fedor; Burford, Brian; Devetyarov, Dmitry; Nouretdinov, Ilia; Gammerman, Alex

    2009-01-01

    In this paper we apply computer learning methods to diagnosing ovarian cancer using the level of the standard biomarker CA125 in conjunction with information provided by mass-spectrometry. We are working with a new data set collected over a period of 7 years. Using the level of CA125 and mass-spectrometry peaks, our algorithm gives probability predictions for the disease. To estimate classification accuracy we convert probability predictions into strict predictions. Our algorithm makes fewer errors than almost any linear combination of the CA125 level and one peak's intensity (taken on the log scale). To check the power of our algorithm we use it to test the hypothesis that CA125 and the peaks do not contain useful information for the prediction of the disease at a particular time before the diagnosis. Our algorithm produces $p$-values that are better than those produced by the algorithm that has been previously applied to this data set. Our conclusion is that the proposed algorithm is more reliable for predi...

  11. The role of uPAR signaling in lung cancer Background and significance

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    The role of uPAR signaling in lung cancer Background and significance Lung cancer is the leading of lung cancer non-small-cell-lung cancer (about 85% of all lung cancer cases) and small- cell-lung cancer (about 15%) (Herbst et al., 2008). Small cell lung carcinoma (SCLC) is rapidly growing and often

  12. Cold atmospheric plasma in cancer therapy

    SciTech Connect (OSTI)

    Keidar, Michael; Shashurin, Alex; Volotskova, Olga; Ann Stepp, Mary; Srinivasan, Priya; Sandler, Anthony; Trink, Barry

    2013-05-15

    Recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in understanding of cold plasma physics as well as application of cold atmospheric plasma (CAP) in cancer therapy. Varieties of novel plasma diagnostic techniques were developed recently in a quest to understand physics of CAP. It was established that the streamer head charge is about 10{sup 8} electrons, the electrical field in the head vicinity is about 10{sup 7} V/m, and the electron density of the streamer column is about 10{sup 19} m{sup ?3}. Both in-vitro and in-vivo studies of CAP action on cancer were performed. It was shown that the cold plasma application selectively eradicates cancer cells in-vitro without damaging normal cells and significantly reduces tumor size in-vivo. Studies indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. It is also shown that the cancer cells are more susceptible to the effects of CAP because a greater percentage of cells are in the S phase of the cell cycle.

  13. Oestrogen metabolism and action in epithelial ovarian cancer

    E-Print Network [OSTI]

    Ren, Xia

    2011-11-25

    Ovarian cancer is the most fatal of all gynecological malignancies. Epithelial ovarian cancer (EOC) accounts for about 90% of malignant ovarian tumours and is thought to originate mostly from ovarian surface epithelium ...

  14. www.yalecancercenter.org The Biology of Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org The Biology of Lung Cancer Guest Expert: Katerina Politi, PhD www lung cancers and cutaneous lymphomas. If you would like to join the conversation, you can contact

  15. SCHOOL OF GRADUATE STUDIES CANCER RESEARCHwww.queensu.ca/cancergradprogram

    E-Print Network [OSTI]

    Fletcher, Robin

    and genetics, through epidemiology, to outcomes research, cell signaling and health policy development designated Cancer Research courses. Participate in the Cancer Research Seminar Series. SUPERVISORS that increase individual susceptibility to carcinogens. Trainees will conduct research developing or employing

  16. Comprehensive genomic characterization of squamous cell lung cancers

    E-Print Network [OSTI]

    Lander, Eric S.

    Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no ...

  17. Molecular Mechanisms of Cannabinoids as Anti-cancer Agents

    E-Print Network [OSTI]

    Sreevalsan, Sandeep

    2013-05-31

    Cancer is a growing health concern world-wide and is the second most common cause of death after heart diseases. Current treatment strategies such as surgery, chemotherapy and radiation provide some relief to cancer patients ...

  18. Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    protein inhibitor of EBV-associated cancer, and can now be used to design proteins to fight other infectious agents and cancers. Some viruses plan for this, and produce proteins...

  19. Microfabricated Optical Sensor Probe for the Detection of Esophageal Cancer

    E-Print Network [OSTI]

    Chinna Balareddy, Karthik Reddy

    2012-10-19

    Cancer is a class of diseases in which a group of cells grow uncontrollably, destroy surrounding tissue and eventually spread to other parts of the body, often leading to death. According to the American Cancer Society ...

  20. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enzyme Structure Provides Insights into Cancer and Aging Enzyme Structure Provides Insights into Cancer and Aging Print Wednesday, 25 February 2009 00:00 XPD helicase is an enzyme...

  1. Boron-Nitride Nanotubes Show Potential in Cancer Treatment |...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Boron-Nitride Nanotubes Show Potential in Cancer Treatment NEWPORT NEWS, VA, April 26 - A new study has shown that adding boron-nitride nanotubes to the surface of cancer cells can...

  2. Function of the anterior gradient protein family in cancer

    E-Print Network [OSTI]

    Fourtouna, Argyro

    2009-01-01

    Proteomic technologies verified Anterior Gradient 2, AGR-2, as a protein over-expressed in human cancers, including breast, prostate and oesophagus cancers, with the ability to inhibit the tumour suppressor protein p53. AGR-2 gene is a hormone...

  3. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  4. Breaking a Pocket of Resistance in the Fight Against Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Breaking a Pocket of Resistance in the Fight Against Cancer Breaking a Pocket of Resistance in the Fight Against Cancer Print Thursday, 12 December 2013 11:55 ras protein The new...

  5. Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

    E-Print Network [OSTI]

    Ooi, Chia Huey

    Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships ...

  6. Spiritual Coping and Adjustment in Siblings of Children with Cancer

    E-Print Network [OSTI]

    Kaal, Julia

    2011-11-23

    Approximately 12 000 US children are diagnosed with some form of cancer every year (Ries et al., 2006).

  7. Vitamin E and the risk of prostate cancer: Updated results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

    E-Print Network [OSTI]

    2012-01-01

    10.1001/jama.2011.1437. Vitamin E and the Risk of Prostateof The Selenium and Vitamin E Cancer Prevention Trial (Effect of Selenium and Vitamin E on Risk of Prostate Cancer

  8. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

    E-Print Network [OSTI]

    Ren, Yin

    A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches. Efforts such as The Cancer Genome Atlas Project will identify genes ...

  9. Algorithms for Detecting Significantly Mutated Pathways in Cancer

    E-Print Network [OSTI]

    Raphael, Ben J.

    Algorithms for Detecting Significantly Mutated Pathways in Cancer Fabio Vandin1, , Eli Upfal2 genome sequencing studies have shown that the so- matic mutations that drive cancer development functional mutations from sporadic, passenger mutations. Since cancer mutations are hypothesized to target

  10. Modeling cancer metabolism on a genome scale Keren Yizhak1,*

    E-Print Network [OSTI]

    Ruppin, Eytan

    Review Modeling cancer metabolism on a genome scale Keren Yizhak1,* , Barbara Chaneton2 , Eyal Gottlieb2 & Eytan Ruppin1,3,4,** Abstract Cancer cells have fundamentally altered cellular metabolism, several new key metabolic alterations in cancer have been established over the last decade, leading

  11. www.yalecancercenter.org Robotic Surgery for Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Robotic Surgery for Lung Cancer Guest Expert: Anthony Kim, MD Assistant and an expert in the use of radiation to treat lung cancers and cutaneous lymphomas. If you would like to join for a conversation about robotic surgery for lung cancer. Here is Francine Foss. Foss Let's start off by talking

  12. www.yalecancercenter.org Non-Small Cell Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Non-Small Cell Lung Cancer Therapies Guest Expert: Roy Decker, MD, Ph Scott, let's start off by discussing why lung cancer is still such a significant public health problem it has decreased in the last 10- 15 years. The incidence of lung cancer might be decreasing a little

  13. EPA 402-R-93-076 ESTIMATING RADIOGENIC CANCER RISKS

    E-Print Network [OSTI]

    comparing health risk estimates due to low level exposures of low-LET radiation based on models recently This document presents a revised methodology for EPA's estimation of cancer risks due to low-LET radiation. With the exception of breast cancer, low-LET radiogenic cancer risks are assumed to be reduced by a dose and dose

  14. [CANCER RESEARCH 62, 56185621, October 1, 2002] Meeting Report

    E-Print Network [OSTI]

    Kimchi, Adi

    [CANCER RESEARCH 62, 56185621, October 1, 2002] Meeting Report Progress in Differentiation of Cancer Research, Chester Beatty Laboratories, London, United Kingdom [A. Z.]; Department of Molecular and pro- grammed cell death as cancer cell-selective therapies. As in the past, the organizers

  15. Cancer Cell Dissecting the Unique Role of the Retinoblastoma

    E-Print Network [OSTI]

    Cancer Cell Article Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has for cancer development; hence, the roles and regulation of RB have been intensively studied (reviewed

  16. Cancer Phylogenetics from Single-Cell Assays Gregory Pennington

    E-Print Network [OSTI]

    Cancer Phylogenetics from Single-Cell Assays Gregory Pennington Stanley Shackney Russell Schwartz the Carnegie Mellon University Berkman Faculty Development Fund. #12;Keywords: computational biology, cancer, FISH, phylogeny #12;Abstract In the field of cancer biology, there is currently great interest

  17. Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy

    E-Print Network [OSTI]

    Smith, Elizabeth Brooks

    2009-05-15

    Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

  18. Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a)

    E-Print Network [OSTI]

    Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a) , Davina Porock(b) , Nick of the study: was to evaluate the attitudinal barriers to cancer-pain management among cnacer patients five factors . These factors contribute to ineffective cancer pain management among them and include

  19. [CANCER RESEARCH 61, 59745978, August 15, 2001] Advances in Brief

    E-Print Network [OSTI]

    Jin, Jiashun

    [CANCER RESEARCH 61, 59745978, August 15, 2001] Advances in Brief Analysis of Gene Expression Identifies Candidate Markers and Pharmacological Targets in Prostate Cancer John B. Welsh, Lisa M. Sapinoso., H. F. F.] Abstract Detection, treatment, and prediction of outcome for men with prostate cancer

  20. No Evidence of Dioxin Cancer Threshold David Mackie1

    E-Print Network [OSTI]

    Thomas, Valerie

    1 No Evidence of Dioxin Cancer Threshold David Mackie1 , Junfeng Liu1 , Yeong-Shang Loh2 , Valerie Environmental Institute, Guyot Hall, Princeton University, Princeton NJ 08544 #12;2 No Evidence of Dioxin Cancer Threshold Key Words: Dioxin, TCDD, Cancer, Threshold Acknowledgements: This work was carried out as part

  1. [CANCER RESEARCH 64, 46934698, July 15, 2004] Advances in Brief

    E-Print Network [OSTI]

    Meucci, Olimpia

    [CANCER RESEARCH 64, 46934698, July 15, 2004] Advances in Brief CX3CR1-Fractalkine Expression Regulates Cellular Mechanisms Involved in Adhesion, Migration, and Survival of Human Prostate Cancer Cells of specific organs by metastatic cancer cells. For instance, the CXCR4- SDF-1 pair regulates adhesion

  2. DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER

    E-Print Network [OSTI]

    Raphael, Ben J.

    DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER FABIO VANDIN, PATRICK CLAY,pclay,eli,braphael}@cs.brown.edu A major goal of cancer sequencing projects is to identify genetic alterations that determine clinical phenotypes, such as survival time or drug response. Somatic mutations in cancer are typically very diverse

  3. Enhancing cancer therapeutics using size-optimized magnetic fluid hyperthermia

    E-Print Network [OSTI]

    Krishnan, Kannan M.

    Enhancing cancer therapeutics using size-optimized magnetic fluid hyperthermia Amit P. Khandhar, R cancer therapeutics using size-optimized magnetic fluid hyperthermia Amit P. Khandhar,1 R. Matthew & Engineering, Seattle, Washington 98195, USA 2 Fred Hutchinson Cancer Research Center, Division of Clinical

  4. An analysis and hypothesis generation platform for heterogeneous cancer

    E-Print Network [OSTI]

    Reed, Chris

    An analysis and hypothesis generation platform for heterogeneous cancer databases. Philip Roy QUINLAN a,1, Alastair THOMPSON a and Chris REED b a Dundee Cancer Centre, University of Dundee, Ninewells Hospital, Dundee b School of Computing, University of Dundee, Dundee Abstract. The field of cancer research

  5. Glucose conjugation for the specific targeting and treatment of cancer

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    Glucose conjugation for the specific targeting and treatment of cancer Emilia C. Calvaresia and Paul J. Hergenrother*ab Cancers of diverse origins exhibit marked glucose avidity and high rates has led to an interest in targeting it for cancer therapy. One promising strategy for such targeting

  6. Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn

    E-Print Network [OSTI]

    Gilsinn, David E.

    Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn Bruce R. Borchardt Amelia Tebbe July 15, 2009 Abstract Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. Computed to- mography (CT) shows promise in detecting lung cancers at earlier, more operable

  7. Targeted CT Screening for Lung Cancer using Absolute Risk Prediction

    E-Print Network [OSTI]

    Brent, Roger

    Targeted CT Screening for Lung Cancer using Absolute Risk Prediction Stephanie A. Kovalchik skovalch@rand.org FHCRC 2014 Risk Prediction Symposium June 11, 2014 1 #12;Outline Lung Cancer Epidemiology and Screening Screening Benefit and Absolute Risk Absolute Risk Model for Lung Cancer

  8. Research Article Epithelial Phenotype Confers Resistance of Ovarian Cancer

    E-Print Network [OSTI]

    Hemminki, Akseli

    Research Article Epithelial Phenotype Confers Resistance of Ovarian Cancer Cells to Oncolytic, Helsinki, Finland Abstract We studied the susceptibility of primary ovarian cancer cells to oncolytic oncolysis, we discovered that the epithelial phenotype of ovarian cancer represents a barrier to infection

  9. Transcriptional Targeting for Ovarian Cancer Gene Therapy E. Casado,*,

    E-Print Network [OSTI]

    Hemminki, Akseli

    REVIEW Transcriptional Targeting for Ovarian Cancer Gene Therapy E. Casado,*, D. M. Nettelbeck Paz, Madrid, Spain Received November 10, 2000 Ovarian carcinoma is a leading cause of cancer death patients diagnosed with ovarian cancer are still low. Therefore, novel molecular therapeutic strat- egies

  10. Physiologic, Metabolic, and Structural Alterations in Breast Cancer

    E-Print Network [OSTI]

    Ramanujam, Nimmi

    Physiologic, Metabolic, and Structural Alterations in Breast Cancer: Assessment via Optical;MOTIVATION METHODOLOGY / TOOLS VALIDATION EX VIVO ANALYSIS IN VIVO ANALYSIS Breast Cancer Facts and Figures Approx. 213,000 women in the US develop invasive breast cancer each year; 62,000 are diagnosed

  11. PRECLINICAL STUDY Prediction of lymph node involvement in breast cancer

    E-Print Network [OSTI]

    PRECLINICAL STUDY Prediction of lymph node involvement in breast cancer from primary tumor tissue- ther lymph node involvement in breast cancer is influenced by gene or miRNA expression of the primary tissue from a group of 96 breast cancer patients balanced for lymph node involvement using Affymetrix

  12. Predicting breast cancer using an expression values weighted clinical classifier

    E-Print Network [OSTI]

    Predicting breast cancer using an expression values weighted clinical classifier Minta Thomas 1. Results: We compared and evaluated the proposed methods on five breast cancer case studies. Compared to LS Curve (AUC), on all breast cancer case studies. Conclusions: Thus a clinical classifier weighted

  13. Implanted adipose progenitor cells as physicochemical regulators of breast cancer

    E-Print Network [OSTI]

    Cohen, Itai

    Implanted adipose progenitor cells as physicochemical regulators of breast cancer Emily M that soluble factors from breast cancer cells inhibit adipogenic differentiation while increasing proliferation surgery for breast cancer, which compose the majority of the 93,000 breast reconstructions per- formed

  14. METHODOLOGY ARTICLE Open Access A simple and reproducible breast cancer

    E-Print Network [OSTI]

    Geman, Donald

    METHODOLOGY ARTICLE Open Access A simple and reproducible breast cancer prognostic test Luigi test for breast cancer based on a 70-gene expression signature. We provide all the software, Personalized medicine, Breast cancer, MammaPrint Background Currently, a number of molecular-based prognostic

  15. COMPUTERIZED BREAST CANCER DIAGNOSIS AND PROGNOSIS FROM FINE NEEDLE ASPIRATES

    E-Print Network [OSTI]

    Street, Nick

    1 COMPUTERIZED BREAST CANCER DIAGNOSIS AND PROGNOSIS FROM FINE NEEDLE ASPIRATES William H. Wolberg methods based on linear programming that were applicable to breast cancer diagnosis and prognostic), and 2) improve breast cancer prognostic estimations. The diagnostic accuracy of FNA to diagnose breast

  16. The Reproductive Factors Linked to Breast Cancer Risk

    E-Print Network [OSTI]

    Chen, Tsuhan

    The Reproductive Factors Linked to Breast Cancer Risk The breast is a reproductive organ, so it makes sense that breast cancer risk would be related to reproductive variables. A woman's own estrogen contributes to the normal development and functioning of the breast, as well as to breast cancer risk. Being

  17. A Systems Approach to Breast Cancer Carcinogenesis to Therapy

    E-Print Network [OSTI]

    A Systems Approach to Breast Cancer Carcinogenesis to Therapy Speaker: Dr. Joe Gray Director, Center for Spatial Systems Biomedicine Oregon Health & Science University Date: Monday, April 18, 2011 that influence cancer behavior, (b) systems biology approaches to elucidate mechanisms by which cancer

  18. Lung Cancer . Author manuscript p16INK4A inactivation mechanisms in non-small-cell lung cancer patients

    E-Print Network [OSTI]

    Boyer, Edmond

    Lung Cancer . Author manuscript Page /1 10 p16INK4A inactivation mechanisms in non-small-cell lung occupational risk factor and that asbestos acts synergistically with tobacco smoking to induce lung cancer. Although some somatic gene alterations in lung cancer have been linked to tobacco smoke, few data

  19. Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: A role in ovarian pathogenesis

    E-Print Network [OSTI]

    Nanjundan, Meera

    2009-01-01

    beta} Signaling in Ovarian Cancer. Cancer Res, 66, 8404-coincides with ovarian cancer resistance to transformingproliferation of human ovarian cancer cells obtained from

  20. Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities

    E-Print Network [OSTI]

    Langland, Gregory T.

    2011-01-01

    platinumresistant ovarian cancer. Expert Opin Pharmacothertherapy in advanced ovarian cancer. Gynecol Oncol 90: S8-The molecular basis of ovarian cancer. Cancer 76 (Suppl 10):

  1. Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency

    E-Print Network [OSTI]

    Yuan, Xiaoqin; Lin, Xinjian; Manorek, Gerald; Howell, Stephen B

    2011-01-01

    overexpressed in ovarian cancer but not in ovariandifferentially expressed in ovarian cancer. Cancer Res 2000,markers for epithelial ovarian cancer with gene expression

  2. Mutational heterogeneity in cancer and the search for new cancer genes

    E-Print Network [OSTI]

    Helman, Elena

    Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched ...

  3. Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

    SciTech Connect (OSTI)

    Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

    2012-07-01

    Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

  4. Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

    E-Print Network [OSTI]

    2012-01-01

    Comparison of 6q25 Breast Cancer Hits from Asian andStudies in the Breast Cancer Association Consortium (BCAC)7 | Issue 8 | e42380 6q25 Breast Cancer GWAS Hits B. ]; the

  5. Small RNA combination therapy for lung cancer

    E-Print Network [OSTI]

    Tammela, Tuomas

    MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering ...

  6. Advances in cancer research: Volume 47

    SciTech Connect (OSTI)

    Klein, G.; Weinhouse, S.

    1986-01-01

    This book contains eight chapters. Some of the titles are: Genetic Epidemiology of Familial Aggregation of Cancer; Terminal Transferase in Normal and Leukemic Cells; Malignant Metamorphosis: Developmental Genes as Culprits for Oncogenesis in Xiphophorus; and Transcription Activation by Viral and Cellular Oncogenes.

  7. Isotope Cancer Treatment Research at LANL

    ScienceCinema (OSTI)

    Weidner, John; Nortier, Meiring

    2014-06-02

    Los Alamos National Laboratory has produced medical isotopes for diagnostic and imaging purposes for more than 30 years. Now LANL researchers have branched out into isotope cancer treatment studies. New results show that an accelerator-based approach can produce clinical trial quantities of actinium-225, an isotope that has promise as a way to kill tumors without damaging surrounding healthy cells.

  8. Original Articles The Nested Structure of Cancer

    E-Print Network [OSTI]

    Bhavnani, Suresh K.

    for the design of systems that assist in symptom assessment and man- agement.The main limitation of the studyOriginal Articles The Nested Structure of Cancer Symptoms Implications for Analyzing Co; 2Michigan Institute for Clinical and Health Research, Ann Arbor, MI, USA; 3Electrical Engineering

  9. Breast Cancer Detection Using Multilevel Thresholding

    E-Print Network [OSTI]

    Rejani, Y Ireaneus Anna

    2009-01-01

    This paper presents an algorithm which aims to assist the radiologist in identifying breast cancer at its earlier stages. It combines several image processing techniques like image negative, thresholding and segmentation techniques for detection of tumor in mammograms. The algorithm is verified by using mammograms from Mammographic Image Analysis Society. The results obtained by applying these techniques are described.

  10. Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis

    SciTech Connect (OSTI)

    Bian, Yongqian [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China); Wang, Li; Lu, Huanyu; Yang, Guodong [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China); Zhang, Zhang [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China); Fu, Haiyan; Lu, Xiaozhao; Wei, Mengying [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China); Sun, Jianyong; Zhao, Qingchuan [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China); Dong, Guanglong, E-mail: gldong301@gmail.com [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China) [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China); Department of General Surgery, The General Hospital of the PLA, Beijing 100853 (China); Lu, Zifan, E-mail: luzfliuq@fmmu.edu.cn [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China)

    2012-05-25

    Highlights: Black-Right-Pointing-Pointer QKI expression is decreased in gastric cancer samples. Black-Right-Pointing-Pointer Promoter hyper methylation contributes to the downregulation of QKI. Black-Right-Pointing-Pointer QKI inhibits the growth of gastric cancer cells. Black-Right-Pointing-Pointer Decreased QKI expression predicts poor survival. -- Abstract: Gastric cancer (GC) is the fourth most common cancer and second leading cause of cancer-related death worldwide. RNA-binding protein Quaking (QKI) is a newly identified tumor suppressor in multiple cancers, while its role in GC is largely unknown. Our study here aimed to clarify the relationship between QKI expression with the clinicopathologic characteristics and the prognosis of GC. In the 222 GC patients' specimens, QKI expression was found to be significantly decreased in most of the GC tissues, which was largely due to promoter hypermethylation. QKI overexpression reduced the proliferation ability of GC cell line in vitro study. In addition, the reduced QKI expression correlated well with poor differentiation status, depth of invasion, gastric lymph node metastasis, distant metastasis, advanced TNM stage, and poor survival. Multivariate analysis showed QKI expression was an independent prognostic factor for patient survival.

  11. Discovery Radiomics for Multi-Parametric MRI Prostate Cancer Detection

    E-Print Network [OSTI]

    Chung, Audrey G; Kumar, Devinder; Khalvati, Farzad; Haider, Masoom A; Wong, Alexander

    2015-01-01

    Prostate cancer is the most diagnosed form of cancer in Canadian men, and is the third leading cause of cancer death. Despite these statistics, prognosis is relatively good with a sufficiently early diagnosis, making fast and reliable prostate cancer detection crucial. As imaging-based prostate cancer screening, such as magnetic resonance imaging (MRI), requires an experienced medical professional to extensively review the data and perform a diagnosis, radiomics-driven methods help streamline the process and has the potential to significantly improve diagnostic accuracy and efficiency, and thus improving patient survival rates. These radiomics-driven methods currently rely on hand-crafted sets of quantitative imaging-based features, which are selected manually and can limit their ability to fully characterize unique prostate cancer tumour phenotype. In this study, we propose a novel \\textit{discovery radiomics} framework for generating custom radiomic sequences tailored for prostate cancer detection. Discover...

  12. Pre-counseling Education for Low Literacy Women at Risk of Hereditary Breast and Ovarian Cancer (HBOC): Patient Experiences Using the Cancer Risk Education Intervention Tool (CREdIT)

    E-Print Network [OSTI]

    2010-01-01

    history of breast or ovarian cancer. JAMA, 293, Axilbund, J.131136. Healthwise (2007) Ovarian cancer: Should I have myremoved to prevent ovarian cancer? Accessed January 14,

  13. Decreased expression of RNA interference machinery, Dicer and Drosha, is associated with poor outcome in ovarian cancer patients

    E-Print Network [OSTI]

    Merritt, William M.

    2009-01-01

    Molecular determinants of ovarian cancer plasticity. Am Jsmall interfering RNA on ovarian cancer cell growth. Journalwith Poor Outcome in Ovarian Cancer Patients William M.

  14. Identifying gaps in breast cancer research: Addressing disparities and the roles of the physical and social environment

    E-Print Network [OSTI]

    2007-01-01

    Physical Environment and Breast Cancer Overarching Issues A.II: Disparities in Breast Cancer: Domains of Individual-Environmental pollutants and breast cancer. Environ Health

  15. Prediction of Breast Cancer Biopsy Outcomes Using a Distributed Genetic Programming Approach

    E-Print Network [OSTI]

    Ludwig, Simone

    Prediction of Breast Cancer Biopsy Outcomes Using a Distributed Genetic Programming Approach Simone@cs.usask.ca ABSTRACT Worldwide, breast cancer is the second most common type of can- cer after lung cancer and the fifth most common cause of cancer death. In 2004, breast cancer caused 519,000 deaths worldwide

  16. The Statewide Cancer Prevention and Control Program (CPCP) was the first formal collaboration between the South Carolina Cancer Center and the Hollings Cancer

    E-Print Network [OSTI]

    Almor, Amit

    collaboration between the South Carolina Cancer Center and the Hollings Cancer Center at the Medical University of South Carolina in Charleston. The CPCP stems from an initiative of Dr. James R. Hebert who, working the ground up. Dr. Hebert is now the Director of the South Carolina Statewide CPCP Currently, the CPCP

  17. Dark matter as a cancer hazard

    E-Print Network [OSTI]

    Chashchina, Olga

    2015-01-01

    We comment on the paper "Dark Matter collisions with the Human Body" by K.~Freese and C.~Savage (Phys.\\ Lett.\\ B {\\bf 717}, 25 (2012) [arXiv:1204.1339]) and describe a dark matter model for which the results of the previous paper do not apply. Within this mirror dark matter model, potentially hazardous objects, mirror micrometeorites, can exist potentially leading to diseases triggered by multiple mutations, such as cancer.

  18. Dark matter as a cancer hazard

    E-Print Network [OSTI]

    Olga Chashchina; Zurab Silagadze

    2015-09-17

    We comment on the paper "Dark Matter collisions with the Human Body" by K.~Freese and C.~Savage (Phys.\\ Lett.\\ B {\\bf 717}, 25 (2012) [arXiv:1204.1339]) and describe a dark matter model for which the results of the previous paper do not apply. Within this mirror dark matter model, potentially hazardous objects, mirror micrometeorites, can exist potentially leading to diseases triggered by multiple mutations, such as cancer.

  19. Latent Variable Modeling in Heterogeneous Populations

    E-Print Network [OSTI]

    Bengt O. Muthn

    2011-01-01

    A final general theme is the standard statistical assump-standard errors of estimates. Referring back to the themes

  20. Compositions and methods for cancer treatment using targeted carbon nanotubes

    DOE Patents [OSTI]

    Harrison, Jr., Roger G; Resasco, Daniel E; Neves, Luis Filipe Ferreira

    2013-08-27

    The present invention is a method for detecting and destroying cancer tumors. The method is based on the concept of associating a linking protein or linking peptide such as, but not limited to, annexin V or other annexins to carbon nanotubes such as single-walled carbon nanotubes (SWNTs) to form a protein-CNT complex. Said linking protein or peptide can selectively bind to cancerous cells, especially tumor vasculature endothelial cells, rather than to healthy ones by binding to cancer-specific external receptors such as anionic phospholipids including phosphatidylserine expressed on the outer surfaces of cancer cells only. Irradiation of bound CNTs with one or more specific electromagnetic wavelengths is then used to detect and destroy those cells to which the CNTs are bound via the linking protein or peptide thereby destroying the tumor or cancer cells and preferably an immunostimulant is provided to the patient to enhance the immune response against antigens released from the tumor or cancer cells.

  1. Translating the cancer genome: Going beyond p values

    SciTech Connect (OSTI)

    Chin, Lynda; Chin, Lynda; Gray, Joe W.

    2008-04-03

    Cancer cells are endowed with diverse biological capabilities driven by myriad inherited and somatic genetic and epigenetic aberrations that commandeer key cancer-relevant pathways. Efforts to elucidate these aberrations began with Boveri's hypothesis of aberrant mitoses causing cancer and continue today with a suite of powerful high-resolution technologies that enable detailed catalogues of genomic aberrations and epigenomic modifications. Tomorrow will likely bring the complete atlas of reversible and irreversible alteration in individual cancers. The challenge now is to discern causal molecular abnormalities from genomic and epigenomic 'noise', to understand how the ensemble of these aberrations collaborate to drive cancer pathophysiology. Here, we highlight lessons learned from now classical examples of successful translation of genomic discoveries into clinical practice, lessons that may be used to guide and accelerate translation of emerging genomic insights into practical clinical endpoints that can impact on practice of cancer medicine.

  2. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Gray, Joe

    2011-04-28

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  3. Genetic heterogeneity in breast cancer: the road to personalised medicine?

    E-Print Network [OSTI]

    Baird, Richard D.; Caldas, Carlos

    2013-06-18

    , Alipaz J, Bauer MJ, Beare D, Butler A, Carter RJ, Chen L, Cox AJ, Edkins S, Kokko- Gonzales PI, Gormley NA, Grocock RJ, Haudenschild CD, Hims MM, James T, Jia M, Kingsbury Z, Leroy C, Marshall J, Menzies A, et al: A comprehensive catalogue of somatic... . Keywords: Breast cancer, Next-generation sequencing, W Personalized medicine, Heterogeneity The genetic heterogeneity seen in breast cancer has important clinical implications In 2008 it was estimated that the annual number of new breast cancer diagnoses...

  4. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-04

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks particularly with regard to breast cancer.

  5. The impact of cancer on the neural activity

    E-Print Network [OSTI]

    Iarosz, Kelly Cristiane; Baptista, Murilo da Silva; Protachevicz, Paulo Ricardo

    2015-01-01

    We study the impact of the decrease in the neural population on the neuronal firing rate. We propose a cellular automaton model from cancerous growth in a brain tissue and the death of neurons due absence of cells that help support to neurons. We use this model to study how the firing rate changes when the neuronal networks is under different external stimuli and the cancerous cells have different proliferation rate. Our work shows that the cancer proliferation decreases the neuronal firing rate.

  6. MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines

    E-Print Network [OSTI]

    Kumar, Smriti R.

    Background: Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive ...

  7. Lymphedema in Breast Cancer Survivors : : Risk Factors, Distress and Quality of Life, and Patient Compliance with a Physician Referral

    E-Print Network [OSTI]

    Dominick, Sally Ann

    11 to 20 nodes ? 21 nodes Breast Cancer Surgery Lumpectomy/Mastectomies Time since Breast Cancer Surgery, yearsKahn KL. Arm edema in breast cancer patients. J Natl Cancer

  8. Development of alternating amphiphilic copolymers for targeted delivery applications in cancer

    E-Print Network [OSTI]

    Brower, Kevin P. (Kevin Peter)

    2011-01-01

    According to the American Cancer Society, approximately 1,479,000 new cases of cancer were expected to be diagnosed, while 562,340 Americans were expected to die from cancer in 2009 alone. Even though advances in early ...

  9. Potential for Cardiovascular Exercise Dosing to Improve Cardiorespiratory Fitness in Breast Cancer Survivors

    E-Print Network [OSTI]

    Burnett, Dave

    2013-05-31

    With an increase in early detection and curative treatment for breast cancer, there is a growing number of breast cancer survivors. Cancer survivors are at greater risk than their age matched peers for long-term health ...

  10. The shared experience of adolescent and young adult cancer patients and their caregivers

    E-Print Network [OSTI]

    Juth, V; Silver, RC; Sender, L

    2015-01-01

    young adult survivors of childhood cancer. Oncology Nursingadults with cancer. Journal of Pediatric Oncology Nursing,adults with cancer: Comparing the findings from two qualitative studies. European Journal of Oncology Nursing,

  11. A theory of the cancer age-specific incidence data based on extreme value distributions

    E-Print Network [OSTI]

    Soto-Ortiz, Luis; Brody, James P

    2012-01-01

    2011). 7 P. Armitage and R. Doll, Br J Cancer 8, 1 (1954). 8P. Armitage and R. Doll, Br J Cancer 91, 1983 (2004). 9 E.10 P. Armitage and R. Doll, Br J Cancer 11, 161 (1957). 11

  12. Cancer survivors and survivorship care: Provider expectations, post-treatment health services, and patient reported outcomes

    E-Print Network [OSTI]

    Hahn, Erin Elizabeth

    2013-01-01

    2011) Long Term Effects and Cancer Survivorship in the OlderGanz (Eds. ), Management of Cancer for the Older Patient (the Quality of Care for Cancer Survivors. Psycho-Oncology (

  13. Cancer Prognosis Through Gene Expression Analysis Steven Buechler, Applied and Computational Mathematics and Statistics,

    E-Print Network [OSTI]

    Buechler, Steven

    Cancer Prognosis Through Gene Expression Analysis Steven Buechler, Applied the breast cancer patients who can avoid chemotherapy without increasing the risk of recurrence. Background. Following the initial surgery, many breast cancer patients

  14. Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer

    E-Print Network [OSTI]

    2007-01-01

    transcription in serous ovarian cancers; prognostic markersnumber changes at 8q24 in ovarian cancer cell lines. Table 2cells Table S1 List of ovarian cancer cell lines used in the

  15. Are ABCB1 (P-glycoprotein) polymorphisms clinically relevant in ovarian cancer? - Finally an Answer!

    E-Print Network [OSTI]

    Konecny, GE

    2013-01-01

    of MDR1 in epithelial ovarian cancer and its associationnucleotide polymorphisms in ovarian cancer tissue: G2677T/Atherapy in advanced ovarian cancer. Anticancer Res 2006;26:

  16. Estrogen withdrawal, increased breast cancer risk and the KRAS-variant

    E-Print Network [OSTI]

    2015-01-01

    menopausal women 3 and ovarian cancer. 4-6 The KRAS-variantvariant patients with ovarian cancer or head and neck cancerincluding breast and ovarian cancer, as well as a third

  17. Recent breast cancer incidence trends according to hormone therapy use: the California Teachers Study cohort

    E-Print Network [OSTI]

    2010-01-01

    European populations. Breast Cancer Res Treat 2008, 107:389-as: Marshall et al. : Recent breast cancer incidence trendsTeachers Study cohort. Breast Cancer Research 2010 12:R4.

  18. PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer

    E-Print Network [OSTI]

    Wishart, Gordon C.; Azzato, Elizabeth M.; Greenberg, David C.; Rashbass, Jem; Kearins, Olive; Lawrence, Gill; Caldas, Carlos; Pharoah, Paul D. P.

    2010-01-06

    Abstract Introduction The aim of this study was to develop and validate a prognostication model to predict overall and breast cancer specific survival for women treated for early breast cancer in the UK. Methods Using the Eastern Cancer Registration...

  19. Unraveling the microenvironmental influences on the normal mammary gland and induction and progression of breast cancer

    E-Print Network [OSTI]

    Weigelt, Britta

    2009-01-01

    hollow lumen. (right) Breast cancer cells form disorganizedFig. 2. Morphologies of breast cancer cell lines cultured inof 4 representative breast cancer cell lines cultured as 2D

  20. Breast Cancer Protein Scrutinized -Softpedia http://news.softpedia.com/news/Breast-Cancer-Protein-Scrutinized-153216.shtml[8/24/2010 4:07:21 PM

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Breast Cancer Protein Scrutinized - Softpedia http://news.softpedia.com/news/Breast-Cancer >> Home > News > Science > Microbiology/Genetics Microbiology/Genetics Breast Cancer Protein Scrutinized the development of new diagnosis and treatment methods for breast cancer, researchers managed to study in depth

  1. 7/3/13 3:01 PMBreast-cancer protein purified Page 2 of 5http://www.news.chauthiduniya.com/breast-cancer-protein-purified

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    7/3/13 3:01 PMBreast-cancer protein purified Page 2 of 5http://www.news.chauthiduniya.com/breast-cancer-protein-purified Health & Yoga Breast-cancer protein purified Share This Tags BREAST CANCERproteinpurified TweetTweet 0 Like 0 submit StumbleUpon London: Scientists have purified the protein produced by the breast cancer

  2. High-dose-rate brachytherapy as monotherapy for prostate cancer

    E-Print Network [OSTI]

    Demanes, DJ; Ghilezan, MI

    2014-01-01

    comparison with HDR brachytherapy and preliminary clinicalrisk prostate cancer. Brachytherapy 2013;12:428e433.Demanes, M.I. Ghilezan / Brachytherapy 13 (2014) 529e541

  3. Nanotechnology in Head and Neck Cancer: The Race Is On

    E-Print Network [OSTI]

    El-Sayed, Ivan H.

    2010-01-01

    10.1007/s11912-010-0087-2 Nanotechnology in Head and Neckthe applications of nanotechnology in head and neck cancer,plasmonic gold nanotechnology. Keywords Nanotechnology .

  4. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in...

  5. Yeast-based vaccine approaches to cancer immunotherapy

    E-Print Network [OSTI]

    Howland, Shanshan W

    2008-01-01

    Saccharomyces cerevisiae stimulates dendritic cells and represents a promising candidate for cancer immunotherapy development. Effective cross-presentation of antigen delivered to dendritic cells is necessary for successful ...

  6. Cell Motility and Deformability in the Pathogenesis of Lung Cancer

    E-Print Network [OSTI]

    Pagano, Paul Carmelo

    2015-01-01

    25-26; Rockville, MD. Philadelphia. xviii 3. Pagano PC, etJan 6-9; San Diego, CA. Philadelphia (PA): AACR Clin Cancer

  7. Identification of cancer protein biomarkers using proteomic techniques

    DOE Patents [OSTI]

    Mor, Gil G. (Cheshire, CT); Ward, David C. (Las Vegas, NV); Bray-Ward, Patricia (Las Vegas, NV)

    2010-02-23

    The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.

  8. Insight into Alzheimer's, cancer, anemia gleaned from ribosome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insights from ribosome research Insight into Alzheimer's, cancer, anemia gleaned from ribosome research Groundbreaking study of the human ribosome reveals tiny molecular machine is...

  9. Protocadherin-7 induces bone metastasis of breast cancer

    SciTech Connect (OSTI)

    Li, Ai-Min; Tian, Ai-Xian; Zhang, Rui-Xue; Ge, Jie; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Sun, Xuan; Cao, Xu-Chen; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin

    2013-07-05

    Highlights: PCDH7 is overexpression in high bone metastatic MDA-MB-231 cells. PCDH7 is up-regulation in bone metastatic breast cancer tissues. Suppression of PCDH7 inhibits cell proliferation, migration, and invasion in vitro. PCDH7 induces breast cancer bone metastasis in vivo. -- Abstract: Breast cancer had a propensity to metastasize to bone, resulting in serious skeletal complications associated with poor outcome. Previous study showed that Protocadherin-7 (PCDH7) play an important role in brain metastatic breast cancer, however, the role of PCDH7 in bone metastatic breast cancer has never been explored. In the present study, we found that PCDH7 expression was up-regulation in bone metastatic breast cancer tissues by real-time PCR and immunohistochemistry assays. Furthermore, suppression of PCDH7 inhibits breast cancer cell proliferation, migration, and invasion in vitro by MTT, scratch, and transwell assays. Most importantly, overexpression of PCDH7 promotes breast cancer cell proliferation and invasion in vitro, and formation of bone metastasis in vivo. These data provide an important insight into the role of PCDH7 in bone metastasis of breast cancer.

  10. Three-Dimensional Thermal Tomography Advances Cancer Treatment...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Three-Dimensional Thermal Tomography Advances Cancer Treatment Technology available for licensing: A 3D technique to detect early skin changes due to radiation treatment in breast...

  11. Locally Advanced Prostate Cancer: Three-Dimensional Magnetic...

    Office of Scientific and Technical Information (OSTI)

    Locally Advanced Prostate Cancer: Three-Dimensional Magnetic Resonance Spectroscopy to Monitor Prostate Response to Therapy Citation Details In-Document Search Title: Locally...

  12. Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL...

    Office of Science (SC) Website

    Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Applications of Nuclear...

  13. Is Primary Prostate Cancer Treatment Influenced by Likelihood...

    Office of Scientific and Technical Information (OSTI)

    Cancer Center, Chapel Hill, NC 2 ; Carpenter, William R. 4 ; Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 2 ;...

  14. From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory

    SciTech Connect (OSTI)

    Martineau, Rebecca M

    2012-07-26

    In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

  15. 7/3/13 10:04 AM2010 Breast Cancer Highlights, Breast Cancer Research Program, Congressionally Directed Medical Research Programs Page 1 of 10http://cdmrp.army.mil/bcrp/research_highlights/2010.shtml#top

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    7/3/13 10:04 AM2010 Breast Cancer Highlights, Breast Cancer Research Program, Congressionally > Breast Cancer > Research Highlights > 2010 Breast Cancer Highlights 2010 Breast Cancer Research Highlights Successful Isolation of BRCA2 (breast cancer type 2 susceptibility protein) and Elucidation of Its

  16. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

    E-Print Network [OSTI]

    2009-01-01

    breast cancer and ovarian cancers as compared with thedence of breast and ovarian cancers, even among women whoof breast cancer and/or ovarian cancer. The current study is

  17. Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change

    E-Print Network [OSTI]

    2012-01-01

    full- length cDNA collection using the following primers: 59-CGA TCT Co-culture of fibroblasts with cancer cells

  18. Plasma Vitamin D and Prostate Cancer Risk: Results from the Selenium and Vitamin E Cancer Prevention Trial

    E-Print Network [OSTI]

    2014-01-01

    Biomarkers & Prevention Plasma Vitamin D and Prostate Cancerfrom the Selenium and Vitamin E Cancer Prevention Trial Alanwho are using supplemental vitamin D should limit their dose

  19. The Study of Mechanical Properties of Cells as a Biomarker for Cancer Diagnostics

    E-Print Network [OSTI]

    Tse, Henry Tat Kwong

    2012-01-01

    Di Carlo, D. (2012). A Mechanical Biomarker of Cell State inusing a microfluidic device for mechanical and electricalOral Cancer Diagnosis by Mechanical Phenotyping. Cancer Res

  20. Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence

    E-Print Network [OSTI]

    Duin, Robert P.W.

    2005-01-01

    Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence bronchoscopy spectroscopy; Lung cancer; Bronchoscopy Summary Detection of malignancies of the bronchial tree in an early

  1. 1Q1 Esterase-activatable -lapachone prodrug micelles for NQO1-targeted 2 lung cancer therapy

    E-Print Network [OSTI]

    Gao, Jinming

    -targeted 2 lung cancer therapy 3Q2 Xinpeng Ma a,1 , Xiumei Huang b,1 , Zachary Moore b , Gang Huang lung cancer 20 Cancer nanomedicine 21Lung cancer is one of the most lethal forms of cancer and current to be highly efficacious in killing non-small cell lung 23cancer (NSCLC) cells regardless of their p53, cell

  2. Targeting NRF2 signaling for cancer chemoprevention

    SciTech Connect (OSTI)

    Kwak, Mi-Kyoung; Kensler, Thomas W.

    2010-04-01

    Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

  3. Successful management of elderly breast cancer patients treated without radiotherapy

    E-Print Network [OSTI]

    Valassiadou, Kalliope; Morgan, David A. L.; Robertson, John F. R.; Pinder, Sarah E.; Cheung, Kwok-Leung

    2007-06-03

    -three cancers were ER positive and 26 were ER negative. ER status was not recorded in four patients. Forty of the 53 ER positive patients were treated with adju- vant tamoxifen. The median size of the cancers was 19 mm (range 2 mm 40 mm). Seventeen patients...

  4. Neural Networks for Breast Cancer Diagnosis School of Computer Science

    E-Print Network [OSTI]

    Yao, Xin

    Neural Networks for Breast Cancer Diagnosis Xin Yao School of Computer Science The University neural network based approaches to breast cancer diag- nosis, both of which have displayed good general- isation. The first approach is based on evolution- ary artificial neural networks. In this approach

  5. www.yalecancercenter.org Coping with a Breast Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    rates of breast cancer. However, Asians who migrate and live in the United States have a higher rate are not at risk of breast cancer. It's a very common disease and in the United States at this time almost one out the fact that the incidence has been increasing, the death rate for most of the last century has remained

  6. Method for detecting the presence of prostate cancer

    DOE Patents [OSTI]

    Karin, Michael; Luo, Jun-Li; Tan, Wei

    2010-04-13

    The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.

  7. Berkeley Lab Scientist Co-Leads Breast Cancer Dream Team

    ScienceCinema (OSTI)

    Gray, Joe

    2013-05-29

    An $16.5 million, three-year grant to develop new and more effective therapies to fight breast cancer was awarded today to a multi-institutional Dream Team of scientists and clinicians that is co-led by Joe Gray, a renowned cancer researcher with the U.S. Department of Energys Lawrence Berkeley National Laboratory. http://newscenter.lbl.gov/

  8. Method for restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

    2000-01-01

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

  9. Recent Progress in Ultra-Wideband Microwave Breast Cancer Detection

    E-Print Network [OSTI]

    Coates, Mark

    were diagnosed in the United States and Canada with as many as 45,000 cases leading to death. For women, breast cancer mortality rates are higher than for any other cancer, with the exception of lung as early as possible. This will not only reduce mortality and incidence rates, but also significantly ease

  10. Lung Cancer and Arsenic Concentrations in Drinking Water in Chile

    E-Print Network [OSTI]

    California at Berkeley, University of

    Lung Cancer and Arsenic Concentrations in Drinking Water in Chile Catterina Ferreccio,1,2 Claudia- trations have since been reduced to 40 g/liter. We investi- gated the relation between lung cancer and arsenic in drinking water in northern Chile in a case-control study involving patients diagnosed with lung

  11. Investigating the initiation and progression of small cell lung cancer

    E-Print Network [OSTI]

    Brauneis, Alison Dooley

    2011-01-01

    Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. ...

  12. Therapeutics, Targets, and Chemical Biology Prostate Cancer Radiosensitization through

    E-Print Network [OSTI]

    Gao, Jinming

    in the United States. It occurs with the highest inci- dence (25%) of all cancers and is the second leading, which were associated with ATP loss and induction of -calpaininduced programmed cell death cause of cancer-related death in men (1). Radiation therapy [X-ray therapy (XRT)] using fractionated low

  13. Berkeley Lab Scientist Co-Leads Breast Cancer Dream Team

    SciTech Connect (OSTI)

    Gray, Joe

    2009-01-01

    An $16.5 million, three-year grant to develop new and more effective therapies to fight breast cancer was awarded today to a multi-institutional Dream Team of scientists and clinicians that is co-led by Joe Gray, a renowned cancer researcher with the U.S. Department of Energys Lawrence Berkeley National Laboratory. http://newscenter.lbl.gov/

  14. Cancer evolution: mathematical models and computational inference

    E-Print Network [OSTI]

    Beerenwinkel, Niko; Schwarz, Roland F.; Gerstung, Moritz; Markowetz, Florian

    2014-10-07

    and the presence of mutator phenotypes make it challenging to separate driver from passenger mutations. To identify genes under positive somatic selection, one can detect an excess of nonsynonymous somatic mutations, that is, a high dN/dS ratio, in cancer genome... sequences. The same genes are often under purifying selection in intergenerational terms leading to a depletion of nonsynonymous polymorphisms in the human population. Based on the idea of a high somatic dN/dS, (Greenman et al. (2006)) formulated a...

  15. Using HEP Technology to Fight Cancer

    SciTech Connect (OSTI)

    Le Du, Patrick

    2004-06-30

    Many engineering and physics HEP groups are now collaborating with medical doctors and biomedical scientists to develop new modern and 'state of the art' radiation instruments for cancer diagnostics and treatment. This presentation will review some of these studies, oriented towards the imaging fields for diagnostic (Positron Emission Tomography and Computed Tomography) and particle therapy for tumor treatment (from proton to light ions). I will try, using appropriate examples, to show what are the challenges and where the development of HEP concepts, tools and techniques can be used.

  16. Laser research shows promise for cancer treatment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse Bergkamp Graduate studentScienceLaboratoryandBryanoutreachCancer treatment

  17. BRCA1-linked marker in postmenopausal breast cancer families

    SciTech Connect (OSTI)

    Folsom, A.R.; Chen, P.L.; Sellers, T.A.

    1994-09-01

    A majority of breast and ovarian cancer families and half of the early-onset breast cancer families are linked to markers on 17q (BRCA1). While linkage has been demonstrated in families with premenopausal disease, few studies have tested these markers in families with postmenopausal breast cancer. In the Iowa Women`s Health Study, a population-based study of over 42,000 women, an association of waist-to-hip ratio (WHR) with the risk of postmenopausal breast cancer was found predominantly in women with a positive family history -- this interaction was associated with a 3.2-fold elevated risk. This effect was even more pronounced when the definition of family history included breast and ovarian cancer, known to be linked to 17q markers. We evaluated evidence for linkage with D17S579, a BRCA-1-linked marker, in 13 families in which the index case had postmenopausal breast cancer. Genotyping for alleles at D17S579 was performed on 84 blood samples. Linkage analysis assumed that the breast cancer trait had an autosomal dominant mode of inheritance with a penetrance of 80%. For the 13 families studied, the maximum lod score was 0.29 at a theta of 0.27. There was significant evidence against tight linkage of breast cancer with D17S579 (theta<0.4). Heterogeneity analysis suggested evidence for the presence of both linked and unlinked families. Partitioning informative families on WHR of the index case suggested heterogeneity. These data suggest that, in a subset of families identified by a postmenopausal breast cancer proband, risk of breast cancer may be mediated by BRCA1, with heterogeneity defined by WHR.

  18. P/1WINTER 2014 Welcome to the Winter 2014 issue of the Stanford Cancer

    E-Print Network [OSTI]

    Puglisi, Joseph

    P/1WINTER 2014 Welcome to the Winter 2014 issue of the Stanford Cancer Institute Clinical Research, and especially physicians who are considering treatment options for their patients with cancer, about clinical trials and programs available at the Stanford Cancer Institute. We have more than 300 cancer clinical

  19. Ref: 13/133 10 July 2013 New hope in the fight against childhood cancer

    E-Print Network [OSTI]

    Molinari, Marc

    Ref: 13/133 10 July 2013 New hope in the fight against childhood cancer Cancer Research UK bring treatments for a particular aggressive form of childhood cancer closer to reality. Researchers in the immune system, potentially heightening the body's own immune response to cancer. Published in the July

  20. National Cancer Institute at the National Institutes of Health Posted: 02/09/2012

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    National Cancer Institute at the National Institutes of Health Posted: 02/09/2012 NCI Cancer Center and copying are strongly linked to cancer, birth defects and other problems. Click here to read full press 66 as Cancer Centers. Largely based in research universities, these facilities are home to many

  1. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

    E-Print Network [OSTI]

    Cai, Long

    Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer, Timothy Anderson6, Norman Gerry7, Joseph Keane4, Marc E Lenburg7 & Jerome S Brody1 Lung cancer smokers with suspicion of lung cancer could be used as a lung cancer biomarker. Using a training set (n

  2. Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 19952007 (the

    E-Print Network [OSTI]

    Maizels, Rick

    1 Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 19952007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data M P Coleman Background Cancer survival is a key measure of the effectiveness of health-care systems. Persistent regional

  3. Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14)

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14 is that this behavior is extremely unhealthy and risky for their bodies, specifically their skin. Skin cancer is the most common form of cancer found in young adults and second most common cancer found in adolescents

  4. Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and

    E-Print Network [OSTI]

    Rosenberg, Michael S.

    Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and geographic We have previously shown that geographic differences in cancer mortalities in Europe are related of 45 male and 47 female cancers. Differences in cancer incidences are correlated moder- ately, first

  5. http://arXiv.org/abs/physics/0011002 A HISTORICAL PERSPECTIVE ON CANCER *

    E-Print Network [OSTI]

    Sorkin, Rafael Dolnick

    http://arXiv.org/abs/physics/0011002 A HISTORICAL PERSPECTIVE ON CANCER * Rafael D. Sorkin@physics.syr.edu Abstract It is proposed that cancer results from the breakdown of universal con trol mechanisms which the damaged control mechanisms and thereby arresting the cancer. More or less by definition, a cancerous cell

  6. http://arXiv.org/abs/physics/0011002 A HISTORICAL PERSPECTIVE ON CANCER *

    E-Print Network [OSTI]

    Sorkin, Rafael Dolnick

    http://arXiv.org/abs/physics/0011002 A HISTORICAL PERSPECTIVE ON CANCER * Rafael D. Sorkin@physics.syr.edu Abstract It is proposed that cancer results from the breakdown of universal con- trol mechanisms which the damaged control mechanisms and thereby arresting the cancer. More or less by definition, a cancerous cell

  7. Cancer classification by gradient LDA technique using microarray gene expression data

    E-Print Network [OSTI]

    Cancer classification by gradient LDA technique using microarray gene expression data Alok Sharma a) Dimensionality reduction Cancer classification Feature selection Feature extraction a b s t r a c t Cancer techniques are applied for cancer classification, they face the small sample size (SSS) problem of gene

  8. TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors

    E-Print Network [OSTI]

    TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk mutations are observed in about 40e70% of lung cancer tissues, and the hot spot codon mu- tations factors that influence TP53 gene mutation in lung cancer patients residing areas with high lung cancer

  9. QCL-based TDLAS sensor for detection of NO toward emission measurements from ovarian cancer cells

    E-Print Network [OSTI]

    QCL-based TDLAS sensor for detection of NO toward emission measurements from ovarian cancer cells M. On the other hand, high concentra- tions of NO can suppress tumor growth [47]. Ovarian cancer is the leading cause of gynecological cancer-related deaths, and *14,270 US women will die of ovarian cancer in 2014 [8

  10. Letter to the Editor Molecular profiling of platinum resistant ovarian cancer: Use of the

    E-Print Network [OSTI]

    Letter to the Editor Molecular profiling of platinum resistant ovarian cancer: Use of the model to predict platin resistance in ovarian cancer. The authors studied a training set obtained from 24 tumours. Molecular profiling of platinum resistant ovar- ian cancer. Int J Cancer 2005;118:196371. 2. Thigpen T

  11. Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells1

    E-Print Network [OSTI]

    Hemminki, Akseli

    of receptor expression and infectivity by Ad, a panel of ovarian cancer cell lines and purified primary cancer displays enhanced infectivity for ovarian cancer cell lines and purified primary tumor cells, which could translate into increased efficacy in clinical trials. INTRODUCTION Epithelial ovarian cancer is the leading

  12. Computer-aided identification of ovarian cancer in confocal microendoscope images

    E-Print Network [OSTI]

    Gmitro, Arthur F.

    Computer-aided identification of ovarian cancer in confocal microendoscope images Saurabh of ovarian cancer is introduced. The cellular-level struc- ture present in ex vivo confocal microendoscope, 2008. 1 Introduction Ovarian cancer is the fifth most common cancer in women. According to statistics

  13. Learning Causal Models for Noisy Biological Data Mining: An Application to Ovarian Cancer Detection

    E-Print Network [OSTI]

    Tan, Ah-Hwee

    Learning Causal Models for Noisy Biological Data Mining: An Application to Ovarian Cancer Detection and accounts for their un- certainties during diagnosis. An application to the problem of ovarian cancer) describe a technique that could identify ovarian cancer patients with perfect sensitivity (cancer

  14. Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular Therapeutic Applications1

    E-Print Network [OSTI]

    Hemminki, Akseli

    Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular therapy of ovarian cancer. Experimental Design: Established and primary ovarian cancer and mesothelial: Consistent activation of the MK and cox-2 promoters was noted in all of the ovarian cancer cell lines

  15. Cancer Therapy: Preclinical Modulating Endogenous NQO1 Levels Identifies Key Regulatory

    E-Print Network [OSTI]

    Gao, Jinming

    Pancreatic cancer is the fourth leading cause of cancer- related death in the United States. (1). Current cancer is the fourth leading cause of cancer-related deaths, in which the 5-year survival rate is less. Results: b-Lapmediated cell death required $90 enzymatic units of NQO1. Essential downstream mediators

  16. Therapeutic Discovery ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

    E-Print Network [OSTI]

    Kenny, Paraic

    Therapeutic Discovery ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer Damara Mc and pumps are a key feature of some cancers, including breast cancer, understanding these calcium influx Orai1, activated by Stim2. Breast cancer cell lines had increased levels of ORAI1. ORAI1 si

  17. Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer

    E-Print Network [OSTI]

    Hemminki, Akseli

    metastatic breast cancer Tuuli Ranki1,2,3 , Merja Sarkioja1,2,3 , Tanja Hakkarainen1,2,3 , Karl von Smitten4- fractory to current treatments, such as hormone refractory meta- static breast cancer. In clinical cancer several capsid-modified oncolytic adenoviruses for the treatment of breast cancer with and without Kupffer

  18. EPIDEMIOLOGY Global and focal brain volume in long-term breast cancer

    E-Print Network [OSTI]

    van Vliet, Lucas J.

    EPIDEMIOLOGY Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant of non-CNS directed chemotherapy-exposed breast cancer survivors, on average 21 years post chemotherapy-exposed breast cancer patients, mean age 64.0 (SD = 6.5) years, who had been diagnosed with cancer

  19. An ex vivo co-culture model system to evaluate stromalepithelial interactions in breast cancer

    E-Print Network [OSTI]

    Cheng, Ji-Xin

    An ex vivo co-culture model system to evaluate stromalepithelial interactions in breast cancer T, Purdue University, West Lafayette, IN Breast cancer is the most commonly diagnosed cancer among women worldwide. High breast cancer incidence and mortality rates, especially in obese patients, emphasize

  20. Aging Impacts Transcriptome but not Genome of Hormone-dependentBreast Cancers

    SciTech Connect (OSTI)

    Yau, Christina; Fedele, Vita; Roydasgupta, Ritu; Fridlyand, Jane; Hubbard, Alan; Gray, Joe W.; Chew, Karen; Dairkee, Shanaz H.; Moore, DanH.; Schittulli, Francesco; Tommasi, Stefania; Paradiso, Angelo; Albertson, Donna G.; Benz, Christopher C.

    2007-10-09

    Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age-at-diagnosis has been shown to be an independent indicator of breast cancer prognosis. However, except for inherited forms of breast cancer, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior.

  1. Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo

    SciTech Connect (OSTI)

    Hashimoto, Kae; Morishige, Ken-ichirou . E-mail: mken@gyne.med.osaka-u.ac.jp; Sawada, Kenjiro; Ogata, Seiji; Tahara, Masahiro; Shimizu, Shoko; Sakata, Masahiro; Tasaka, Keiichi; Kimura, Tadashi

    2007-04-27

    Geranylgeranylacetone (GGA), an isoprenoid compound, is an anti-ulcer drug developed in Japan. In our previous study, GGA was shown to inhibit ovarian cancer invasion by attenuating Rho activation [K. Hashimoto, K. Morishige, K. Sawada, M. Tahara, S. Shimizu, M. Sakata, K. Tasaka, Y. Murata, Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro. Cancer 103 (2005) 1529-1536.]. In the present study, GGA treatment inhibited ovarian cancer progression in vitro and suppressed the tumor growth and ascites in the in vivo ovarian cancer model. In vitro analysis, treatment of cancer cells by GGA resulted in the inhibition of cancer cell proliferation, the inactivation of Ras, and the suppression of tyrosine phosphorylation of mitogen-activated protein kinase (MAPK). In conclusion, this is the first report that GGA inhibited ovarian cancer progression and the anti-tumor effect by GGA is, at least in part, derived not only from the suppression of Rho activation but also Ras-MAPK activation.

  2. Practice Patterns of Radiotherapy in Cervical Cancer Among Member Groups of the Gynecologic Cancer Intergroup (GCIG)

    SciTech Connect (OSTI)

    Gaffney, David K. . E-mail: david.gaffney@hci.utah.edu; Du Bois, Andreas; Narayan, Kailash; Reed, Nick; Toita, Takafumi; Pignata, Sandro; Blake, Peter; Portelance, Lorraine; Sadoyze, Azmat; Poetter, Richard; Colombo, Alessandro; Randall, Marcus; Mirza, Mansoor R.; Trimble, Edward L.

    2007-06-01

    Purpose: The aim of this study was to describe radiotherapeutic practice of the treatment of cervical cancer in member groups of the Gynecologic Cancer Intergroup (GCIG). Methods and Materials: A survey was developed and distributed to the members of the GCIG focusing on details of radiotherapy practice. Different scenarios were queried including advanced cervical cancer, postoperative patients, and para-aortic-positive lymph node cases. Items focused on indications for radiation therapy, radiation fields, dose, use of chemotherapy, brachytherapy and others. The cooperative groups from North America were compared with the other groups to evaluate potential differences in radiotherapy doses. Results: A total of 39 surveys were returned from 13 different cooperative groups. For the treatment of advanced cervical cancer, external beam pelvic doses and total doses to point A were 47 + 3.5 Gy (mean + SD) and 79.1 + 7.9 Gy, respectively. Point A doses were not different between the North American cooperative groups compared with the others (p = 0.103). All groups used concomitant chemotherapy, with 30 of 36 respondents using weekly cisplatin. Of 33 respondents, 31 intervened for a low hemoglobin level. For a para-aortic field, the upper border was most commonly (15 of 24) at the T12-L1 interspace. Maintenance chemotherapy (after radiotherapy) was not performed by 68% of respondents. For vaginal brachytherapy after hysterectomy, 23 groups performed HDR brachytherapy and four groups used LDR brachytherapy. In the use of brachytherapy, there was no uniformity in dose prescription. Conclusions: Radiotherapy practices among member groups of the GCIG are similar in terms of both doses and use of chemotherapy.

  3. Cancer survival: global variation and long-term trends

    E-Print Network [OSTI]

    Lyratzopoulos, Georgios

    2015-03-03

    diagnosed with breast cancer between 2005 and 2009, net 5-year survival exceeded 80% in most developed countries, but was probably lower than 60% in Algeria, South Africa, Mongolia, and Jordan.1 Considering the overall number of potentially avoidable years... statistics, 2014. CA Cancer J. Clin. 64, 929 (2014). 8. De Angelis, R. et al. Cancer survival in Europe 19992007 by country and age: results of EUROCARE--5-a population-based study. Lancet Oncol. 15, 2334 (2014). 9. Perme, M. P., Stare, J. & Estve, J...

  4. The Kauai Skin Cancer Study--1983 to 1992

    SciTech Connect (OSTI)

    Reizner, G.T. )

    1993-05-01

    The Kauai Skin Cancer Study began as a modest effort in 1983 to look at this island's skin cancer incidence. David Elpern MD, Kauai's only dermatologist at the time, was interested in the large number of these tumors in his practice. He first enlisted his office staff to help keep track of the numbers and type of these skin cancers. Along with this information, the basic demographic data on each patient was collected. These records became the first entries into what has become a decade-long project.

  5. STAT3 regulated ARF expression suppresses prostate cancer metastasis

    E-Print Network [OSTI]

    Pencik, Jan; Schlederer, Michaela; Gruber, Wolfgang; Unger, Christine; Walker, Steven M.; Chalaris, Athena; Mari, Isabelle J.; Hassler, Melanie R.; Javaheri, Tahereh; Aksoy, Osman; Blayney, Jaine K.; Prutsch, Nicole; Skucha, Anna; Herac, Merima; Krmer, Oliver H.; Mazal, Peter; Grebien, Florian; Egger, Gerda; Poli, Valeria; Mikulits, Wolfgang; Eferl, Robert; Esterbauer, Harald; Kennedy, Richard; Fend, Falko; Scharpf, Marcus; Braun, Martin; Perner, Sven; Levy, David E.; Malcolm, Tim; Turner, Suzanne D.; Haitel, Andrea; Susani, Martin; Moazzami, Ali; Rose-John, Stefan; Aberger, Fritz; Merkel, Olaf; Moriggl, Richard; Culig, Zoran; Dolznig, Helmut; Kenner, Lukas

    2015-01-01

    P cells due to the lack of JAK1 gene expression. Cancer Res 65, 3447-53 (2005). 32. Hedvat, M. et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 16, 487-97 (2009). 33. Lou, W., Ni, Z., Dyer... . Nat Rev Cancer 6, 663-73 (2006). 49. Chen, Z. et al. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci Signal 2, ra44 (2009). 50. Kamijo, T., Bodner, S., van de Kamp, E., Randle, D.H. & Sherr, C.J. Tumor spectrum in ARF...

  6. Radiotherapy in the management of early breast cancer

    SciTech Connect (OSTI)

    Wang, Wei

    2013-03-15

    Radiotherapy is an indispensible part of the management of all stages of breast cancer. In this article, the common indications for radiotherapy in the management of early breast cancer (stages 0, I, and II) are reviewed, including whole-breast radiotherapy as part of breast-conserving treatment for early invasive breast cancer and pre-invasive disease of ductal carcinoma in situ, post-mastectomy radiotherapy, locoregional radiotherapy, and partial breast irradiation. Key clinical studies that underpin our current practice are discussed briefly.

  7. Protein Modifications as Potential Biomarkers in Breast Cancer

    SciTech Connect (OSTI)

    Jin, Hongjun; Zangar, Richard C.

    2009-11-30

    A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.

  8. Detection of eight BRCA1 mutations in 10 breast/ovarian cancer families, including 1 family with male breast cancer

    SciTech Connect (OSTI)

    Sruewing, J.P.; Brody, L.C.; Erdos, M.R.

    1995-07-01

    Genetic epidemiological evidence suggests that mutations in BRCA1 may be responsible for approximately one half of early onset familial breast cancer and the majority of familial breast/ovarian cancer. The recent cloning of BRCA1 allows for the direct detection of mutations, but the feasibility of presymptomatic screening for cancer susceptibility is unknown. We analyzed genomic DNA from one affected individual from each of 24 families with at least three cases of ovarian or breast cancer, using SSCP assays. Variant SSCP bands were subcloned and sequenced. Allele-specific oligonucleotide hybridization was used to verify sequence changes and to screen DNA from control individuals. Six frameshift and two missense mutations were detected in 10 different families. A frameshift mutation was detected in a male proband affected with both breast and prostate cancer. A 40-bp deletion was detected in a patient who developed intra-abdominal carcinomatosis 1 year after prophylactic oophorectomy. Mutations were detected throughout the gene, and only one was detected in more than a single family. These results provide further evidence that inherited breast and ovarian cancer can occur as a consequence of a wide array of BRCA1 mutations. These results suggests that development of a screening test for BRCA1 mutations will be technically challenging. The finding of a mutation in a family with male breast cancer, not previously thought to be related to BRCA1, also illustrates the potential difficulties of genetic counseling for individuals known to carry mutations. 37 refs., 1 fig., 1 tab.

  9. Colony-Stimulating Factor-1 Receptor Inhibition Reverses the Vascular Leakage that Causes Malignant Ascites in Late-Stage Epithelial Ovarian Cancer

    E-Print Network [OSTI]

    Moughon, Diana Louise

    2015-01-01

    HC, Ledermann JA. Ovarian cancer. The Lancet. 2014 Oct88. Quirk JT, Natarajan N. Ovarian cancer incidence in theand Treatment of Ovarian Cancer: Shifting from Early Stage

  10. A Pilot study of the Sharing Risk Information Tool (ShaRIT) for Families with Hereditary Breast and Ovarian Cancer Syndrome

    E-Print Network [OSTI]

    Kardashian, Ani; Fehniger, Julia; Creasman, Jennifer; Cheung, Eleanor; Beattie, Mary

    2012-01-01

    Hereditary Breast and Ovarian Cancer Syndrome. Hereditaryrisks of breast and ovarian cancer associated with BRCA1 orMandell JB: Breast and ovarian cancer risks due to inherited

  11. Targeted resequencing of the microRNAome and 3?UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer

    E-Print Network [OSTI]

    2015-01-01

    target for therapy in ovarian cancer. Oncogene 2012; 31:1 Agarwal R, Kaye SB. Ovarian cancer: strategies forgenetic basis of ovarian cancer and its roadmap towards a

  12. Gene expression profiles in irradiated cancer cells

    SciTech Connect (OSTI)

    Minafra, L.; Bravat, V.; Russo, G.; Ripamonti, M.; Gilardi, M. C.

    2013-07-26

    Knowledge of the molecular and genetic mechanisms underlying cellular response to radiation may provide new avenues to develop innovative predictive tests of radiosensitivity of tumours and normal tissues and to improve individual therapy. Nowadays very few studies describe molecular changes induced by hadrontherapy treatments, therefore this field has to be explored and clarified. High-throughput methodologies, such as DNA microarray, allow us to analyse mRNA expression of thousands of genes simultaneously in order to discover new genes and pathways as targets of response to hadrontherapy. Our aim is to elucidate the molecular networks involved in the sensitivity/resistance of cancer cell lines subjected to hadrontherapy treatments with a genomewide approach by using cDNA microarray technology to identify gene expression profiles and candidate genes responsible of differential cellular responses.

  13. Intraoperative radiation therapy in recurrent ovarian cancer

    SciTech Connect (OSTI)

    Yap, O.W. Stephanie . E-mail: stbeast@stanford.edu; Kapp, Daniel S.; Teng, Nelson N.H.; Husain, Amreen

    2005-11-15

    Purpose: To evaluate disease outcomes and complications in patients with recurrent ovarian cancer treated with cytoreductive surgery and intraoperative radiation therapy (IORT). Methods and Materials: A retrospective study of 24 consecutive patients with ovarian carcinoma who underwent secondary cytoreduction and intraoperative radiation therapy at our institution between 1994 and 2002 was conducted. After optimal cytoreductive surgery, IORT was delivered with orthovoltage X-rays (200 kVp) using individually sized and beveled cone applications. Outcomes measures were local control of disease, progression-free interval, overall survival, and treatment-related complications. Results: Of these 24 patients, 22 were available for follow-up analysis. Additional treatment at the time of and after IORT included whole abdominopelvic radiation, 9; pelvic or locoregional radiation, 5; chemotherapy, 6; and no adjuvant treatment, 2. IORT doses ranged from 9-14 Gy (median, 12 Gy). The anatomic sites treated were pelvis (sidewalls, vaginal cuff, presacral area, anterior pubis), para-aortic and paracaval lymph node beds, inguinal region, or porta hepatitis. At a median follow-up of 24 months, 5 patients remain free of disease, whereas 17 patients have recurred, of whom 4 are alive with disease and 13 died from disease. Five patients recurred within the radiation fields for a locoregional relapse rate of 32% and 12 patients recurred at distant sites with a median time to recurrence of 13.7 months. Five-year overall survival was 22% with a median survival of 26 months from time of IORT. Nine patients (41%) experienced Grade 3 toxicities from their treatments. Conclusion: In carefully selected patients with locally recurrent ovarian cancer, combined IORT and tumor reductive surgery is reasonably tolerated and may contribute to achieving local control and disease palliation.

  14. Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer

    E-Print Network [OSTI]

    Faber, Anthony C.

    BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in small-cell lung cancer (SCLC) and other solid tumor malignancies, ...

  15. Targeting nucleic acids for pancreatic cancer: disease modeling and therapy

    E-Print Network [OSTI]

    Lo, Justin Han Je

    2015-01-01

    Pancreatic cancer is responsible for nearly 40,000 deaths in the U.S. annually, with a dismal 5-year survival rate below 7%. The poor therapeutic outcomes reflect a paucity of new approaches targeting the genomic underpinnings ...

  16. Characterizing deformability and surface friction of cancer cells

    E-Print Network [OSTI]

    Byun, Sangwon

    Metastasis requires the penetration of cancer cells through tight spaces, which is mediated by the physical properties of the cells as well as their interactions with the confined environment. Various microfluidic approaches ...

  17. The use of polarized light for skin cancer detecton

    E-Print Network [OSTI]

    DeLaughter, Aimee Hill

    2002-01-01

    detection system. Presented here is a method for the optical determination of cancerous tissue using polarized light. This thesis describes the development of a polarimetric imaging system including its calibration and testing. In addition, experiments...

  18. Investigating immune surveillance, tolerance, and therapy in cancer

    E-Print Network [OSTI]

    Cheung, Ann F

    2009-01-01

    Maximizing the potential of cancer immunotherapy requires model systems that closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems ...

  19. Novel mechanisms of endothelial-epithelial interactions underlying cancer metastasis

    E-Print Network [OSTI]

    Connor, Yamicia Doyasi

    2013-01-01

    Elucidation of molecular mechanisms underlying metastasis is the final frontier in cancer biology research. Identifying individual pathways in the metastatic cascade could lead to development of metastasis-specific ...

  20. Measuring the effects of drugs on single cancer cell growth

    E-Print Network [OSTI]

    Weng, Yaochung

    2012-01-01

    Understanding the effectiveness of a drug therapy on halting disease progression is an essential aspect of cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response ...

  1. Breast cancer incidence following preeclampsia or gestational hypertension

    E-Print Network [OSTI]

    Wormuth, Jennifer Karen

    1997-01-01

    A retrospective cohort study was conducted to examine the relationship between preeclampsia or gestational hypertension and subsequent breast cancer in a population of 6,564 pregnant women. Data on the study population came from the Child Health...

  2. Systems consequences of amplicon formation in human breast cancer

    E-Print Network [OSTI]

    Inaki, Koichiro

    Chromosomal structural variations play an important role in determining the transcriptional landscape of human breast cancers. To assess the nature of these structural variations, we analyzed eight breast tumor samples ...

  3. Tumour microenvironment interactions of small cell lung cancer.

    E-Print Network [OSTI]

    Hodkinson, Philip Simon

    2009-01-01

    Small cell lung cancer (SCLC) is characterised by rapid growth, early metastatic spread and poor long-term survival. The tumour is initially sensitive to chemotherapy and thus objective response rates are high. Unfortunately, ...

  4. Selectins Mediate Small Cell Lung Cancer Systemic Metastasis

    E-Print Network [OSTI]

    Heidemann, Franziska

    Metastasis formation is the major reason for the extremely poor prognosis in small cell lung cancer (SCLC) patients. The molecular interaction partners regulating metastasis formation in SCLC are largely unidentified, ...

  5. Text Mining in Cancer Gene and Pathway Prioritization

    E-Print Network [OSTI]

    Riedlinger, Gregory

    Prioritization of cancer implicated genes has received growing attention as an effective way to reduce wet lab cost by computational analysis that ranks candidate genes according to the likelihood that experimental ...

  6. Genomics at the Ontario Institute for Cancer Research

    SciTech Connect (OSTI)

    Ali, Johar

    2010-06-02

    Johar Ali of the Ontario Institute for Cancer Research discusses genomics and next-gen applications at the OICR on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  7. Our Role in the War on Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Our Role in the War on Cancer Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window) Click to share on...

  8. Jackson Poulos Gene Expression Profiling in Cancer Diagnosis

    E-Print Network [OSTI]

    Brutlag, Doug

    is oncogenesis, or the formation and creation of cancerous tumor cells (Delaval). At its most basic level, oncogenesis involved a cell's internal mechanisms becoming altered in order to allow for uninhibited cell

  9. An Analytical Method For Multi-class Molecular Cancer Classification

    E-Print Network [OSTI]

    Poggio, Tomaso

    Institute / Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139 Vector Machines. We apply this methodology to the diagnosis of multiple common adult malignancies using using standard clinical and histopathologic approaches. Molecular approaches to cancer classification

  10. Targeting the tight junction : immunotherapy of colon cancer

    E-Print Network [OSTI]

    Ackerman, Margaret E

    2010-01-01

    A33 is a cell surface glycoprotein of colon epithelium with a long clinical history as a target in antibody-based cancer therapy. Despite being present in normal colon, radio-labeled antibodies against A33 are selectively ...

  11. Cell Death Pathways in Photodynamic Therapy of Cancer

    E-Print Network [OSTI]

    Mroz, Pawel

    Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ...

  12. Overshoot during phenotypic switching of cancer cell populations

    E-Print Network [OSTI]

    Sellerio, Alessandro L; Ben-Moshe, Noa Bossel; Coco, Stefania; Piccinini, Andrea; Myers, Christopher R; Sethna, James P; Giampietro, Costanza; Zapperi, Stefano; La Porta, Caterina A M

    2015-01-01

    The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a subpopulation of cancer stem cells (CSCs), or are stochastic transitions that mutate differentiated cancer cells to CSCs important? Here we argue that regulation must also be important. We sort human melanoma cells using three distinct cancer stem cell (CSC) markers - CXCR6, CD271 and ABCG2 - and observe that the fraction of non-CSC-marked cells first overshoots to a higher level and then returns to the level of unsorted cells. This clearly indicates that the CSC population is homeostatically regulated. Combining experimental measurements with theoretical modeling and numerical simulations, we show that the population dynamics of cancer cells is associated with a complex miRNA network regulating the Wnt and PI3K pathways. Hence phenotypic switching is not stochastic, but is tightly regulated by the balance between positive and negative cells in the population. Reducing the fraction of CSCs below a threshold tr...

  13. Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Print Immortality is not a good thing for cells, and in fact, cells will destroy themselves in a process called...

  14. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism...

  15. Nested methylation-specific polymerase chain reaction cancer detection method

    DOE Patents [OSTI]

    Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

    2007-05-08

    A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

  16. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  17. Scanxiety: Waiting anxiously for childhood cancer test results...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    results that could change your life Mark Frontera 2015.09.18 September is Childhood Cancer Awareness Month and we are publishing a series of blog posts to share stories about...

  18. Oncotripsy: Targeting cancer cells selectively via resonant harmonic excitation

    E-Print Network [OSTI]

    Heyden, Stefanie

    2015-01-01

    We investigate a method of selectively targeting cancer cells by means of ultrasound harmonic excitation at their resonance frequency, which we refer to as oncotripsy. The geometric model of the cells takes into account the cytoplasm, nucleus and nucleolus, as well as the plasma membrane and nuclear envelope. Material properties are varied within a pathophysiologically-relevant range. A first modal analysis reveals the existence of a spectral gap between the natural frequencies and, most importantly, resonant growth rates of healthy and cancerous cells. The results of the modal analysis are verified by simulating the fully-nonlinear transient response of healthy and cancerous cells at resonance. The fully nonlinear analysis confirms that cancerous cells can be selectively taken to lysis by the application of carefully tuned ultrasound harmonic excitation while simultaneously leaving healthy cells intact.

  19. Cornell dots research collaboration leads to $10M cancer center...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cornell dots research collaboration leads to 10M cancer center September 24th, 2015 ProvidedWiesner Lab A rendering of the molecular structure of a Cornell dot, which is...

  20. Doctor Patient Conversation Around Breast Cancer | GE Global...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Doctor Patient Conversation Around Breast Cancer Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window)...

  1. Technology Relay Race in Cancer Prevention Research | GE Global...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Technology Relay Race in Cancer Prevention Research Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new...

  2. Analysis of alterations in the human cancer genome

    E-Print Network [OSTI]

    Carter, Scott L. (Scott Lambert)

    2011-01-01

    Aneuploidy, an abnormal complement of chromosomes, is present in approximately 90% of human malignancies. Despite over 100 years of research, many questions remain regarding the contribution of aneuploidy to the cancer ...

  3. Breast Cancer Diagnosis and Prognosis via Linear Programming \\Lambda Olvi L. Mangasarian, W. Nick Street y & William H. Wolberg z

    E-Print Network [OSTI]

    Street, Nick

    Breast Cancer Diagnosis and Prognosis via Linear Programming \\Lambda Olvi L. Mangasarian, W. Nick cancer diagnosis and prognosis. The first application to breast cancer diagnosis utilizes characteristics breast cancer is likely to recur in patients that have had their cancers excised. This gives

  4. Genetic heterogeneity in breast cancer: the road to personalized medicine?

    E-Print Network [OSTI]

    Baird, Richard D.; Caldas, Carlos

    2013-06-21

    , Alipaz J, Bauer MJ, Beare D, Butler A, Carter RJ, Chen L, Cox AJ, Edkins S, Kokko- Gonzales PI, Gormley NA, Grocock RJ, Haudenschild CD, Hims MM, James T, Jia M, Kingsbury Z, Leroy C, Marshall J, Menzies A, et al: A comprehensive catalogue of somatic... , Next-generation sequencing, W Personalized medicine, Heterogeneity The genetic heterogeneity seen in breast cancer has important clinical implications In 2008 it was estimated that the annual number of new breast cancer diagnoses globally...

  5. Bone Cancer Rates in Dinosaurs Compared with Modern Vertebrates

    E-Print Network [OSTI]

    L. C. Natarajan; A. L. Melott; B. M. Rothschild; L. D. Martin

    2007-10-16

    Data on the prevalence of bone cancer in dinosaurs is available from past radiological examination of preserved bones. We statistically test this data for consistency with rates extrapolated from information on bone cancer in modern vertebrates, and find that there is no evidence of a different rate. Thus, this test provides no support for a possible role of ionizing radiation in the K-T extinction event.

  6. MicroRNA expression in canine mammary cancer

    E-Print Network [OSTI]

    Boggs, Rene' Michelle

    2008-10-10

    to act as both tumor suppressors and oncogenes in several different cancers, expression patterns of ten miRNAs (miR-15a, miR-16, miR-17-5p, miR-21, miR-29b, miR-125b, miR-145, miR-155, miR-181b, let-7f) known to be associated with human breast cancer were...

  7. Abstract --In USA, breast cancer is a most frequent cause of deaths for women. It is important to detect the cancer in its early

    E-Print Network [OSTI]

    Abstract -- In USA, breast cancer is a most frequent cause of deaths for women. It is important in USA. Women have a much better chance of surviving breast cancer if the disease can be detected early to detect the cancer in its early stage. X-ray three-dimensional (3D) mammography can provide a good image

  8. [CANCER RESEARCH 61, 54205424, July 15, 2001] Modification of BRCA1-and BRCA2-associated Breast Cancer Risk by AIB1

    E-Print Network [OSTI]

    Brown, Myles

    [CANCER RESEARCH 61, 54205424, July 15, 2001] Modification of BRCA1- and BRCA2-associated Breast/2) genes have a greatly increased risk of developing breast cancer compared with the general population. However, there is also substantial interindividual variability in the occurrence of breast cancer among

  9. What is the probability that radiation caused a particular cancer

    SciTech Connect (OSTI)

    Voelz, G.L.

    1983-01-01

    Courts, lawyers, health physicists, physicians, and others are searching for a credible answer to the question posed in the title of this paper. The cases in which the question arises frequently stem from an individual that has cancer and they, or their next-of-kin, are convinced that a past radiation exposure - usually small - is responsible for causing it. An arithmetic expression of this problem is simple: the probability of causation by the radiation dose in question is equal to the risk of cancer from the radiation dose divided by the risk of cancer from all causes. The application of risk factors to this equation is not so simple. It must involve careful evaluation of the reliability of and variations in risk coefficients for development of cancer due to radiation exposure, other carcinogenic agents, and natural causes for the particular individual. Examination of our knowledge of these various factors indicates that a large range in the answers can result due to the variability and imprecision of the data. Nevertheless, the attempts to calculate and the probability that radiation caused the cancer is extremely useful to provide a gross perspective on the probability of causation. It will likely rule in or out a significant number of cases despite the limitations in our understandings of the etiology of cancer and the risks from various factors. For the remaining cases, a thoughtful and educated judgment based on selected data and circumstances of the case will also be needed before the expert can develop and support his opinion.

  10. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells

    E-Print Network [OSTI]

    and their relationships to nonstem cancer cells (NSCCs) are poorly understood. In an inducible breast oncogenesis model address these questions using an inducible model of oncogenesis that involves nontransformed mammary

  11. Volumetric modulated arc radiotherapy for esophageal cancer

    SciTech Connect (OSTI)

    Vivekanandan, Nagarajan, E-mail: viveknaren@hotmail.com [Department of Medical Physics, Cancer Institute, Chennai (India); Sriram, Padmanaban; Syam Kumar, S.A.; Bhuvaneswari, Narayanan; Saranya, Kamalakannan [Department of Medical Physics, Cancer Institute, Chennai (India)

    2012-04-01

    A treatment planning study was performed to evaluate the performance of volumetric arc modulation with RapidArc (RA) against 3D conformal radiation therapy (3D-CRT) and conventional intensity-modulated radiation therapy (IMRT) techniques for esophageal cancer. Computed tomgraphy scans of 10 patients were included in the study. 3D-CRT, 4-field IMRT, and single-arc and double-arc RA plans were generated with the aim to spare organs at risk (OAR) and healthy tissue while enforcing highly conformal target coverage. The planning objective was to deliver 54 Gy to the planning target volume (PTV) in 30 fractions. Plans were evaluated based on target conformity and dose-volume histograms of organs at risk (lung, spinal cord, and heart). The monitor unit (MU) and treatment delivery time were also evaluated to measure the treatment efficiency. The IMRT plan improves target conformity and spares OAR when compared with 3D-CRT. Target conformity improved with RA plans compared with IMRT. The mean lung dose was similar in all techniques. However, RA plans showed a reduction in the volume of the lung irradiated at V{sub 20Gy} and V{sub 30Gy} dose levels (range, 4.62-17.98%) compared with IMRT plans. The mean dose and D{sub 35%} of heart for the RA plans were better than the IMRT by 0.5-5.8%. Mean V{sub 10Gy} and integral dose to healthy tissue were almost similar in all techniques. But RA plans resulted in a reduced low-level dose bath (15-20 Gy) in the range of 14-16% compared with IMRT plans. The average MU needed to deliver the prescribed dose by RA technique was reduced by 20-25% compared with IMRT technique. The preliminary study on RA for esophageal cancers showed improvements in sparing OAR and healthy tissue with reduced beam-on time, whereas only double-arc RA offered improved target coverage compared with IMRT and 3D-CRT plans.

  12. Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy

    E-Print Network [OSTI]

    2014-01-01

    in advanced-stage ovarian cancer: a Phase III Trial of the3 weeks for advanced ovarian cancer: a phase 3, open-label,receptor alpha in ovarian cancer. Onkologie 2009; National

  13. A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer

    E-Print Network [OSTI]

    Yau, Christina; Esserman, Laura; Moore, Dan H; Waldman, Fred; Sninsky, John; Benz, Christopher C

    2010-01-01

    hormone receptor-negative and triple-negative breast cancer.Breast Cancer Research 2010 12:R85. Submit your nexttreating triple-negative breast cancer. Oncology 2008, 22:

  14. An integrative genomic and proteomic analysis of PIK3CA, PTEN and AKT mutations in breast cancer

    E-Print Network [OSTI]

    Stemke-Hale, Katherine

    2009-01-01

    receptor-positive breast cancer patients treated only withPTEN and AKT mutations in breast cancer Running title: PI3Kpathway mutations in breast cancer Katherine Stemke-Hale

  15. The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer

    E-Print Network [OSTI]

    Hu, Zhi

    2010-01-01

    predicts the sensitivity to radiotherapy in breast cancer.Breast Cancer Research 2010 12:R18. Submit your nextnode-negative primary breast cancer. Lancet 2005, 365:671-

  16. Residential radon and lung cancer incidence in a Danish cohort

    SciTech Connect (OSTI)

    Braeuner, Elvira V., E-mail: ole@cancer.dk [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Danish Building Research Institute, Aalborg University (Denmark); Andersen, Claus E. [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark)] [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark); Sorensen, Mette [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Jovanovic Andersen, Zorana [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark) [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Center for Epidemiology Screening, Department of Public Health, University of Copenhagen (Denmark); Gravesen, Peter [Geological Survey of Denmark and Greenland, Copenhagen (Denmark)] [Geological Survey of Denmark and Greenland, Copenhagen (Denmark); Ulbak, Kaare [National Institute of Radiation Protection, Herlev (Denmark)] [National Institute of Radiation Protection, Herlev (Denmark); Hertel, Ole [Department of Environmental Science, Aarhus University, Aarhus (Denmark)] [Department of Environmental Science, Aarhus University, Aarhus (Denmark); Pedersen, Camilla [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Overvad, Kim [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark)] [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark); Tjonneland, Anne; Raaschou-Nielsen, Ole [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)

    2012-10-15

    High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993-1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed. Median estimated radon was 35.8 Bq/m{sup 3}. The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69-1.56) in association with a 100 Bq/m{sup 3} higher radon concentration and 1.67 (95% CI: 0.69-4.04) among non-smokers. We found no evidence of effect modification. We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

  17. Microsatellite instability is rare in sporadic ovarian cancer

    SciTech Connect (OSTI)

    Chen, S.S.; Han, H.; Schwartz, P.E.

    1994-09-01

    Microsatellite instability was first demonstrated to be a common underlying mechanism in hereditary nonpolyposis colorectal cancer (HNPCC) and has recently been implicated in the development of several other human cancers. Although numerous genetic changes have been documented in ovarian cancer, their molecular bases are poorly understood. In investigating the molecular genetics of ovarian cancer, we analyzed twelve short tandem repeats that were amplified by PCR from DNA of 48 tumors and their corresponding lymphocyte samples. All of the 48 cases studied have no noticeable family history and, of them, 42 are epithelial (benign/borderline, 5; grade I, 4; GII, 4; GIII, 29) and 6 are nonepithelial. A microsatellite instability has been shown to be inversely correlated with the occurrence of allelic losses, half of those cases chosen have a fractional allele loss of {le}15 (median = .18 of 50 tumors tested for 86 loci from every chromosomal arm). The loci examined included eight dinucleotide repeats (D2S123, D9S104, D10S197, D11S904, D16S408, D16S421, D17S250, and D17S579), two trinucleotide repeats (DM and AR) and two tetranucleotide repeats (DXS981 and VWF). Despite the fact that HNPCC phenotype includes ovarian cancer and that microsatellite instability has been shown in one ovarian cancer from an HNPCC family, the allele sizes of 12 loci were found to be identical in all paired tumor and normal samples we studied except for one tumor at a single locus. The band shift displayed on polyacrylamide gel representing an additional allele of VWF was only observed in one grade III tumor. Our results are thus a strong indication that the alteration of microsatellite repeats may not play a major role in the development of sporadic ovarian cancer.

  18. Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells

    SciTech Connect (OSTI)

    Hamada, Shin [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan); Masamune, Atsushi, E-mail: amasamune@med.tohoku.ac.jp [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan); Takikawa, Tetsuya; Suzuki, Noriaki; Kikuta, Kazuhiro; Hirota, Morihisa [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan); Hamada, Hirofumi [Laboratory of Oncology, Department of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji (Japan)] [Laboratory of Oncology, Department of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji (Japan); Kobune, Masayoshi [Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo (Japan)] [Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo (Japan); Satoh, Kennichi [Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori (Japan)] [Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori (Japan); Shimosegawa, Tooru [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)

    2012-05-04

    Highlights: Black-Right-Pointing-Pointer Pancreatic stellate cells (PSCs) promote the progression of pancreatic cancer. Black-Right-Pointing-Pointer Pancreatic cancer cells co-cultured with PSCs showed enhanced spheroid formation. Black-Right-Pointing-Pointer Expression of stem cell-related genes ABCG2, Nestin and LIN28 was increased. Black-Right-Pointing-Pointer Co-injection of PSCs enhanced tumorigenicity of pancreatic cancer cells in vivo. Black-Right-Pointing-Pointer This study suggested a novel role of PSCs as a part of the cancer stem cell niche. -- Abstract: The interaction between pancreatic cancer cells and pancreatic stellate cells (PSCs), a major profibrogenic cell type in the pancreas, is receiving increasing attention. There is accumulating evidence that PSCs promote the progression of pancreatic cancer by increasing cancer cell proliferation and invasion as well as by protecting them from radiation- and gemcitabine-induced apoptosis. Recent studies have identified that a portion of cancer cells, called 'cancer stem cells', within the entire cancer tissue harbor highly tumorigenic and chemo-resistant phenotypes, which lead to the recurrence after surgery or re-growth of the tumor. The mechanisms that maintain the 'stemness' of these cells remain largely unknown. We hypothesized that PSCs might enhance the cancer stem cell-like phenotypes in pancreatic cancer cells. Indirect co-culture of pancreatic cancer cells with PSCs enhanced the spheroid-forming ability of cancer cells and induced the expression of cancer stem cell-related genes ABCG2, Nestin and LIN28. In addition, co-injection of PSCs enhanced tumorigenicity of pancreatic cancer cells in vivo. These results suggested a novel role of PSCs as a part of the cancer stem cell niche.

  19. An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families

    SciTech Connect (OSTI)

    Narod, S.A.; Ford, D.; Devilee, P.; Barkardottir, R.B.; Lynch, H.T.; Smith, S.A.; Ponder, B.A.J.; Weber, B.L.; Garber, J.E.; Birch, J.M.

    1995-01-01

    The breast-ovary cancer-family syndrome is a dominant predisposition to cancer of the breast and ovaries which has been mapped to chromosome region 17q12-q21. The majority, but not all, of breast-ovary cancer families show linkage to this susceptibility locus, designated BRCA1. We report the results of a linkage analysis of 145 families with both breast and ovarian cancer. These families contain either a total of three or more cases of early-onset (before age 60 years) breast cancer or ovarian cancer. All families contained at least one case of ovarian cancer. Overall, an estimated 76% of the 145 families are linked to the BRCA1 locus. None of the 13 families with cases of male breast cancer appear to be linked, but it is estimated that 92% (95% confidence interval 76%-100%) of families with no male breast cancer and with two or more ovarian cancers are linked to BRCA1. These data suggest that the breast-ovarian cancer-family syndrome is genetically heterogeneous. However, the large majority of families with early-onset breast cancer and with two or more cases of ovarian cancer are likely to be due to BRCA1 mutations. 39 refs., 6 figs., 3 tabs.

  20. cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction

    SciTech Connect (OSTI)

    Son, Jieun; Lee, Jong-Ho; Kim, Ha-Neui; Ha, Hyunil Lee, Zang Hee

    2010-07-23

    Research highlights: {yields} CREB is highly expressed in advanced breast cancer cells. {yields} Tumor-related factors such as TGF-{beta} further elevate CREB expression. {yields} CREB upregulation stimulates metastatic potential of breast cancer cells. {yields} CREB signaling is required for breast cancer-induced bone destruction. -- Abstract: cAMP-response-element-binding protein (CREB) signaling has been reported to be associated with cancer development and poor clinical outcome in various types of cancer. However, it remains to be elucidated whether CREB is involved in breast cancer development and osteotropism. Here, we found that metastatic MDA-MB-231 breast cancer cells exhibited higher CREB expression than did non-metastatic MCF-7 cells and that CREB expression was further increased by several soluble factors linked to cancer progression, such as IL-1, IGF-1, and TGF-{beta}. Using wild-type CREB and a dominant-negative form (K-CREB), we found that CREB signaling positively regulated the proliferation, migration, and invasion of MDA-MB-231 cells. In addition, K-CREB prevented MDA-MB-231 cell-induced osteolytic lesions in a mouse model of cancer metastasis. Furthermore, CREB signaling in cancer cells regulated the gene expression of PTHrP, MMPs, and OPG, which are closely involved in cancer metastasis and bone destruction. These results indicate that breast cancer cells acquire CREB overexpression during their development and that this CREB upregulation plays an important role in multiple steps of breast cancer bone metastasis.

  1. Elevated levels of somatic mutation of the glycophorin A locus in cancer patients: Relevance for incidence of secondary cancer

    SciTech Connect (OSTI)

    Grant, S.G.; Bigbee, W.L. [Univ. of Pittsburgh, PA (United States)

    1994-09-01

    The glycophorin A (GPA)-based human in vivo somatic mutation assay was used to survey a large number of newly diagnosed cancer patients presenting with a variety of solid tumors. This cancer patient population was sampled pre-therapy and frequencies of two types of variant cells determined: allele loss segregants arising by mutation, deletion, chromosome loss or gene inactivation, and allele loss and duplication segregants arising by chromosome missegregation, mitotic recombination and possibly gene conversion. When compared with matched controls, the cancer patient population exhibited significantly elevated frequencies of both types of segregants. Cancer patients undergoing genotoxic therapy with chemicals and/or ionizing radiation were then examined, yielding variable results depending on the particular agent. In patients receiving localized high dose radiotherapy there was no response with either endpoint. In most cases involving chemotherapy, a significant elevation in the frequency of allele loss variants was observed within one month of the initiation of therapy which persisted at least one erythrocyte lifetime ({approximately}4 months) post therapy. In a subset of these cases, specifically, involving the known stem cell mutagen cis-platinum, the allele loss variant cell frequency remained significantly elevated up to 7 years after treatment. These results indicate that individuals with cancer have inherently higher levels of somatic mutation and segregation, due to genetic predisposition or exposure to environmental genotoxicants, or both, and that certain types of cancer therapy add significantly to the burden of mutation. These data provide a molecular rationale for the increased frequency of secondary malignancy observed in primary cancer patients: they are at increased risk of already having or easily acquiring the necessary carcinogenic events implicated in the progression of multi-step oncogenesis.

  2. Sexual Function in Males After Radiotherapy for Rectal Cancer

    SciTech Connect (OSTI)

    Bruheim, Kjersti, E-mail: Kjersti.bruheim@medisin.uio.n [Oslo University Hospital, Ulleval Cancer Centre, Oslo (Norway); Guren, Marianne G. [Oslo University Hospital, Ulleval Cancer Centre, Oslo (Norway); Dahl, Alv A. [Oslo University Hospital, Department of Clinical Cancer Research, the Norwegian Radium Hospital, Oslo (Norway); Faculty of Medicine, University of Oslo, Oslo (Norway); Skovlund, Eva [School of Pharmacy, University of Oslo, Oslo (Norway); Balteskard, Lise [University Hospital of Northern Norway, Tromso (Norway); Carlsen, Erik [Oslo University Hospital, Department of Gastrointestinal Surgery, Ulleval, Oslo (Norway); Fossa, Sophie D. [Oslo University Hospital, Department of Clinical Cancer Research, the Norwegian Radium Hospital, Oslo (Norway); Faculty of Medicine, University of Oslo, Oslo (Norway); Tveit, Kjell Magne [Oslo University Hospital, Ulleval Cancer Centre, Oslo (Norway); Faculty of Medicine, University of Oslo, Oslo (Norway)

    2010-03-15

    Purpose: Knowledge of sexual problems after pre- or postoperative radiotherapy (RT) with 50 Gy for rectal cancer is limited. In this study, we aimed to compare self-rated sexual functioning in irradiated (RT+) and nonirradiated (RT-) male patients at least 2 years after surgery for rectal cancer. Methods and Materials: Patients diagnosed with rectal cancer from 1993 to 2003 were identified from the Norwegian Rectal Cancer Registry. Male patients without recurrence at the time of the study. The International Index of Erectile Function, a self-rated instrument, was used to assess sexual functioning, and serum levels of serum testosterone were measured. Results: Questionnaires were returned from 241 patients a median of 4.5 years after surgery. The median age was 67 years at survey. RT+ patients (n = 108) had significantly poorer scores for erectile function, orgasmic function, intercourse satisfaction, and overall satisfaction with sex life compared with RT- patients (n = 133). In multiple age-adjusted analysis, the odds ratio for moderate-severe erectile dysfunction in RT+ patients was 7.3 compared with RT- patients (p <0.001). Furthermore, erectile dysfunction of this degree was associated with low serum testosterone (p = 0.01). Conclusion: RT for rectal cancer is associated with significant long-term effects on sexual function in males.

  3. Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells

    E-Print Network [OSTI]

    Papa, Anne-Laure

    Background: Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical ...

  4. Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis

    E-Print Network [OSTI]

    Jackson, Erica L. (Erica Lynn), 1973-

    2003-01-01

    Lung cancer is the leading cause of cancer deaths worldwide. Patients are typically diagnosed with advanced disease and have a high fatality:case ratio. Despite its prevalence, the identity of the cell of origin, precursor ...

  5. Nuclear Factor I/B is an Oncogene in Small Cell Lung Cancer

    E-Print Network [OSTI]

    Dooley, Alison L.

    Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. ...

  6. Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling

    E-Print Network [OSTI]

    Gupta, Piyush

    Many tumors contain heterogeneous populations of cells, only some of which exhibit increased tumorigenicity and resistance to anticancer therapies. Evidence suggests that these aggressive cancer cells, often termed cancer ...

  7. Can A Virus Cause Cancer: A Look Into The History And Significance Of Oncoviruses

    E-Print Network [OSTI]

    Rwazavian, Niema

    2011-01-01

    zur Hausen. Herald. 1991. Viruses in Human Cancers. Science.Deilson E. 2007. DNA Viruses in Human Cancer: An IntegratedRous: Father of the Tumor Virus. Journal of Experimental

  8. Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

    E-Print Network [OSTI]

    Fillmore, Christine M.

    Cancer cells within individual tumors often exist in distinct phenotypic states that differ in functional attributes. While cancer cell populations typically display distinctive equilibria in the proportion of cells in ...

  9. Julie Gralow, MD Director Breast Medical Oncology, Seattle Cancer Care Alliance

    E-Print Network [OSTI]

    Brent, Roger

    Julie Gralow, MD Director Breast Medical Oncology, Seattle Cancer Care Alliance Founder Care Alliance, as well as a Member of the Clinical Research Division of the Fred Hutchinson Cancer

  10. The Design and Manufacturability of Metastasis Mimetic Devices Used for Cancer Research

    E-Print Network [OSTI]

    White III, John Preston

    2012-12-31

    Metastatic cancer causes the death in 80% of its patients, due to the failure of detecting the metastatic events early enough and the failure to effectively treat and eliminate the metastatic cancer cells. A limited understanding of the molecular...

  11. Overcoming cancer therapy resistance by targeting inhibitors of apoptosis proteins and nuclear factor-kappa B

    E-Print Network [OSTI]

    Dai, Yao; Lawrence, Theodore S.; Xu, Liang

    2008-10-25

    Chemo- or radioresistance markedly impairs the efficacy of cancer therapy and involves anti-apoptotic signal transduction pathways that prevent cell death. In resistant cancer cells, both inhibitors of apoptosis proteins ...

  12. Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Target ID4

    E-Print Network [OSTI]

    Ren, Yin

    The comprehensive characterization of a large number of cancer genomes will eventually lead to a compendium of genetic alterations in specific cancers. Unfortunately, the number and complexity of identified alterations ...

  13. Study of inflammatory signalling in epithelial ovarian cancer and the normal human mesothelium

    E-Print Network [OSTI]

    Fegan, Kenneth Scott

    2010-01-01

    Epithelial Ovarian Cancer (EOC) kills more women annually in the United Kingdom than any other gynaecological cancer. Survival rates for women diagnosed with EOC have not improved over the past 30 years, due to the often ...

  14. A general method for studying autocrine signaling and its impact on cancer cell growth

    E-Print Network [OSTI]

    Sampattavanich, Somponnat

    2011-01-01

    Autocrine signaling plays essential roles in providing self-sustaining growth signals to cancer cells. Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine signaling in cancer medicine ...

  15. Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer

    E-Print Network [OSTI]

    Steine, Eveline J.

    Human cancer cells frequently have regions of their DNA hypermethylated, which results in transcriptional silencing of affected genes and promotion of tumor formation. However, it is still unknown whether cancer-associated ...

  16. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

    E-Print Network [OSTI]

    Lander, Eric S.

    Prostate cancer is the second most common cancer in men worldwide and causes over 250,000 deaths each year. Overtreatment of indolent disease also results in significant morbidity. Common genetic alterations in prostate ...

  17. High-order chromatin architecture determines the landscape of chromosomal alterations in cancer

    E-Print Network [OSTI]

    Fudenberg, Geoffrey

    The accumulation of data on structural variation in cancer genomes provides an opportunity to better understand the mechanisms of genomic alterations and the forces of selection that act upon these alterations in cancer. ...

  18. Role of intracellular signalling pathways in conferring resistance to endocrine therapies in breast cancer

    E-Print Network [OSTI]

    Cerqueira, Vera

    2010-01-01

    Breast cancer is the most prevalent form of cancer in women and accounts for 519,000 annual deaths (WHO Statistics). It has long been established that oestrogen (E2) stimulates tumour growth of oestrogen receptor (ER) ...

  19. Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

    E-Print Network [OSTI]

    Mavaddat, Nasim; Pharoah, Paul D. P.; Michailidou, Kyriaki; Tyrer, Jonathan; Brook, Mark N.; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Dunning, Alison M.; Shah, Mitul; Luben, Robert; Brown, Judith; Bojesen, Stig E.; Nordestgaard, Brge G.; Nielsen, Sune F.; Flyger, Henrik; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Peto, Julian; dos-Santos-Silva, Isabel; Dudbridge, Frank; Johnson, Nichola; Schmidt, Marjanka K.; Broeks, Annegien; Verhoef, Senno; Rutgers, Emiel J.; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Schoemaker, Minouk J.; Figueroa, Jonine; Chanock, Stephen J.; Brinton, Louise; Lissowska, Jolanta; Couch, Fergus J.; Olson, Janet E.; Vachon, Celine; Pankratz, Vernon S.; Lambrechts, Diether; Wildiers, Hans; Van Ongeval, Chantal; van Limbergen, Erik; Kristensen, Vessela; Grenaker Alns, Grethe; Nord, Silje; Borresen-Dale, Anne-Lise; Nevanlinna, Heli; Muranen, Taru A.; Aittomki, Kristiina; Blomqvist, Carl; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Fasching, Peter A.; Haeberle, Lothar; Ekici, Arif B.; Beckmann, Matthias W.; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Trentham-Dietz, Amy; Newcomb, Polly; Titus, Linda; Egan, Kathleen M.; Hunter, David J.; Lindstrom, Sara; Tamimi, Rulla M.; Kraft, Peter; Rahman, Nazneen; Turnbull, Clare; Renwick, Anthony; Seal, Sheila; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Benitez, Javier; Pilar Zamora, M.; Arias Perez, Jose Ignacio; Menndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Bogdanova, Natalia V.; Antonenkova, Natalia N.; Drk, Thilo; Anton-Culver, Hoda; Neuhausen, Susan L.; Ziogas, Argyrios; Bernstein, Leslie; Devilee, Peter; Tollenaar, Robert A. E. M.; Seynaeve, Caroline; van Asperen, Christi J.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Khusnutdinova, Elza; Bermisheva, Marina; Prokofyeva, Darya; Takhirova, Zalina; Meindl, Alfons; Schmutzler, Rita K.; Sutter, Christian; Yang, Rongxi; Schrmann, Peter; Bremer, Michael; Christiansen, Hans; Park-Simon, Tjoung-Won; Hillemanns, Peter; Gunel, Pascal; Truong, Thrse; Menegaux, Florence; Sanchez, Marie; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Pensotti, Valeria; Hopper, John L.; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C.; Brauch, Hiltrud; Brning, Thomas; Ko, Yon-Dschun; Sigurdson, Alice J.; Doody, Michele M.; Hamann, Ute; Torres, Diana; Ulmer, Hans-Ulrich; Frsti, Asta; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Marie Mulligan, Anna; Chenevix-Trench, Georgia; Balleine, Rosemary; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Lindblom, Annika; Margolin, Sara; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Eilber, Ursula; Wang-Gohrke, Shan; Hooning, Maartje J.; Hollestelle, Antoinette; van den Ouweland, Ans M. W.; Koppert, Linetta B.; Carpenter, Jane; Clarke, Christine; Scott, Rodney; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Brenner, Hermann; Arndt, Volker; Stegmaier, Christa; Karina Dieffenbach, Aida; Winqvist, Robert; Pylks, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Offit, Kenneth; Vijai, Joseph; Robson, Mark; Rau-Murthy, Rohini; Dwek, Miriam; Swann, Ruth; Annie Perkins, Katherine; Goldberg, Mark S.; Labrche, France; Dumont, Martine; Eccles, Diana M.; Tapper, William J.; Rafiq, Sajjad; John, Esther M.; Whittemore, Alice S.; Slager, Susan; Yannoukakos, Drakoulis; Toland, Amanda E.; Yao, Song; Zheng, Wei; Halverson, Sandra L.; Gonzlez-Neira, Anna; Pita, Guillermo; Rosario Alonso, M.; lvarez, Nuria; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Baynes, Caroline; Ahmed, Shahana; Maranian, Mel; Healey, Catherine S.; Simard, Jacques; Hall, Per; Easton, Douglas F.; Garcia-Closas, Montserrat

    2015-04-02

    Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical...

  20. Molecular biomarker discovery and physiological assessment of skeletal muscle in cancer cachexia

    E-Print Network [OSTI]

    Stephens, Nathan Andrew

    2014-07-05

    Cachexia affects up to two thirds of all cancer patients with progressive disease. It is a syndrome characterised by weight-loss, anorexia, fatigue, asthenia, peripheral oedema, and is responsible for around 20% of cancer ...