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Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Firefighter Fatality & Injury Studies  

Science Conference Proceedings (OSTI)

... Firefighter Fatality & Injury Studies. Wind-Driven Fire in a Ranch-Style House in Texas, 2009. On April 12, 2009, a fire in ...

2013-07-16T23:59:59.000Z

2

Latent Matcher Fusion  

Science Conference Proceedings (OSTI)

Page 1. Latent Matcher Fusion -- Lessons Learned IAI ... 14 Page 15. The Fusion was in Two Steps • Step 1 – a reduced working candidate list was ...

2012-08-07T23:59:59.000Z

3

Bayesian Nonparametric Latent Feature Models  

E-Print Network (OSTI)

3 Bayesian Nonparametric Latent Feature Model Inference5 Non-exchangeable Bayesian Nonparametric Inferencefor Non-exchangeable Bayesian Nonparametric Latent ture

Miller, Kurt Tadayuki

2011-01-01T23:59:59.000Z

4

Latent effects decision analysis  

DOE Patents (OSTI)

Latent effects on a system are broken down into components ranging from those far removed in time from the system under study (latent) to those which closely effect changes in the system. Each component is provided with weighted inputs either by a user or from outputs of other components. A non-linear mathematical process known as `soft aggregation` is performed on the inputs to each component to provide information relating to the component. This information is combined in decreasing order of latency to the system to provide a quantifiable measure of an attribute of a system (e.g., safety) or to test hypotheses (e.g., for forensic deduction or decisions about various system design options).

Cooper, J. Arlin (Albuquerque, NM); Werner, Paul W. (Albuquerque, NM)

2004-08-24T23:59:59.000Z

5

Latent heat accumulating greenhouse  

Science Conference Proceedings (OSTI)

This invention relates to a latent heat accumulating greenhouse utilizing solar heat. The object of the invention is to provide a greenhouse which is simple in construction, of high efficiency for heat absorbing and capable of much absorbing and accumulating of heat. A heat accumulating chamber partitioned by transparent sheets is provided between the attic and a floor surface facing north in the greenhouse. A blower fan is disposed to confront an opening provided at the lower portion in said heat accumulating chamber. Also, in the heat accumulating chamber, a heat accumulating unit having a large number of light transmitting windows and enclosing a phase transformation heat accumulating material such as CaC1/sub 2/.6H/sub 2/O, Na/sub 2/SO/sub 4/.10H/sub 2/O therein is detachably suspended in a position close to windowpanes at the north side.

Yano, N.; Ito, H.; Makido, I.

1985-04-16T23:59:59.000Z

6

Content Modeling Using Latent Permutations  

E-Print Network (OSTI)

We present a novel Bayesian topic model for learning discourse-level document structure. Our model leverages insights from discourse theory to constrain latent topic assignments in a way that reflects the underlying ...

Chen, Harr

7

Flood Fatalities in the United States  

Science Conference Proceedings (OSTI)

This study compiles a nationwide database of flood fatalities for the contiguous United States from 1959 to 2005. Assembled data include the location of fatalities, age and gender of victims, activity and/or setting of fatalities, and the type of ...

Sharon T. Ashley; Walker S. Ashley

2008-03-01T23:59:59.000Z

8

ARM - Measurement - Latent heat flux  

NLE Websites -- All DOE Office Websites (Extended Search)

govMeasurementsLatent heat flux govMeasurementsLatent heat flux ARM Data Discovery Browse Data Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send Measurement : Latent heat flux The time rate of flow for the specific enthalpy difference between two phases of a substance at the same temperature, typically water. Categories Surface Properties Instruments The above measurement is considered scientifically relevant for the following instruments. Refer to the datastream (netcdf) file headers of each instrument for a list of all available measurements, including those recorded for diagnostic or quality assurance purposes. ARM Instruments CO2FLX : Carbon Dioxide Flux Measurement Systems ECOR : Eddy Correlation Flux Measurement System EBBR : Energy Balance Bowen Ratio Station

9

Retrieval of Latent Heating from TRMM Measurements  

Science Conference Proceedings (OSTI)

Rainfall is a fundamental process within the Earth's hydrological cycle because it represents a principal forcing term in surface water budgets, while its energetics corollary, latent heating, is the principal source of atmospheric diabatic ...

W-K. Tao; E. A. Smith; R. F. Adler; A. Y. Hou; R. Meneghini; J. Simpson; Z. S. Haddad; T. Iguchi; S. Satoh; R. Kakar; T. N. Krishnamurti; C. D. Kummerow; S. Lang; K. Nakamura; T. Nakazawa; K. Okamoto; S. Shige; W. S. Olson; Y. Takayabu; G. J. Tripoli; S. Yang

2006-11-01T23:59:59.000Z

10

Latent Heat Induced Energy Transformations during Cyclogenesis  

Science Conference Proceedings (OSTI)

Using real-data numerical simulation experiments, latent heat induced energy transformations during the development of the wave cyclone of 20 May 1977 are investigated. During a 24 h period over 5 cm of precipitation fell despite baroclinically ...

C. B. Chang; D. J. Pepkey; C. W. Kreitzberg

1984-02-01T23:59:59.000Z

11

Exploiting Latent I/O Asynchrony in Petascale Science Applications  

Science Conference Proceedings (OSTI)

We present a collection of techniques for exploiting latent I/O asynchrony which can substantially improve performance in data-intensive parallel applications. Latent asynchrony refers to an applicationâ??s tolerance for decoupling ancillary operations ...

Patrick Widener; Matthew Wolf; Hasan Abbasi; Scott Mcmanus; Mary Payne; Matthew Barrick; Jack Pulikottil; Patrick Bridges; Karsten Schwan

2011-05-01T23:59:59.000Z

12

Consistent and efficient reconstruction of latent tree models  

E-Print Network (OSTI)

We study the problem of learning a latent tree graphical model where samples are available only from a subset of variables. We propose two consistent and computationally efficient algorithms for learning minimal latent ...

Choi, Myung Jin

13

Latent Cracking of Tantalum - Titanium Welds Due to Hydrogen ...  

Science Conference Proceedings (OSTI)

About this Abstract. Meeting, Materials Science & Technology 2012. Symposium, Environmentally Assisted Cracking of Materials. Presentation Title, Latent ...

14

Knowledge transfer across multilingual corpora via latent topics  

Science Conference Proceedings (OSTI)

This paper explores bridging the content of two different languages via latent topics. Specifically, we propose a unified probabilistic model to simultaneously model latent topics from bilingual corpora that discuss comparable content and use the topics ... Keywords: cross-lingual knowledge transfer, latent topic models, text categorization

Wim De Smet; Jie Tang; Marie-Francine Moens

2011-05-01T23:59:59.000Z

15

OE Summary 2006-05: Preliminary Findings on Fatal Explosion...  

NLE Websites -- All DOE Office Websites (Extended Search)

PRELIMINARY FINDINGS ON FATAL EXPLOSION AT TEXAS REFINERY Operating Experience Summary 2005-11 described the March 23, 2005, explosions at the BP America Refinery in Texas City,...

16

Fatal Crash Trends and Analysis in Southeastern States .  

E-Print Network (OSTI)

??Southeastern states have about 26 percent of the nations total fatalities, and are about 24 percent above the national mean over recent years. Descriptive statistics,… (more)

Wang, Chunyan

2006-01-01T23:59:59.000Z

17

Projecting Fatalities in Crashes involving Older Drivers  

NLE Websites -- All DOE Office Websites (Extended Search)

Crashes Crashes Projecting Fatalities in Crashes Involving Older Drivers Involving Older Drivers Oak Oak Ridge Ridge National Laboratory National Laboratory, USA USA Presented at Presented at the the 17th 17th World Congress of the International World Congress of the International Association Association for Accident and Traffic Medicine for Accident and Traffic Medicine May May 30, 30, 2000, 2000, Stockholm, Sweden Stockholm, Sweden ORNL ORNL P. P. Hu Hu D. D. Jones Jones T. T. Reuscher Reuscher R. R. Schmoyer Schmoyer T. T. Truett Truett General General Motors Motors Annette Annette Irwin Irwin U.S. U.S. DOTransportation DOTransportation Jesse Jesse Blatt Blatt Acknowledgements Acknowledgements Objective Objective This This research research is is funded funded by by a a Cooperative Cooperative Research

18

Generic Text Summarization Using Probabilistic Latent Semantic Indexing  

E-Print Network (OSTI)

Generic Text Summarization Using Probabilistic Latent Semantic Indexing Harendra Bhandari Graduate School of Information Science Nara Institute of Science and Technology Nara 630-0192, Japan harendra

19

The Relationship between Tornadic and Nontornadic Convective Wind Fatalities and Warnings  

Science Conference Proceedings (OSTI)

A database of tornado fatalities, nontornadic convective wind fatalities, severe thunderstorm warnings, and tornado warnings was compiled for the period 1986–2007 to assess the spatial and temporal distribution of warned and unwarned fatalities. ...

Alan W. Black; Walker S. Ashley

2011-01-01T23:59:59.000Z

20

Sequential Inference for Latent Force Models  

E-Print Network (OSTI)

Latent force models (LFMs) are hybrid models combining mechanistic principles with non-parametric components. In this article, we shall show how LFMs can be equivalently formulated and solved using the state variable approach. We shall also show how the Gaussian process prior used in LFMs can be equivalently formulated as a linear statespace model driven by a white noise process and how inference on the resulting model can be efficiently implemented using Kalman filter and smoother. Then we shall show how the recently proposed switching LFM can be reformulated using the state variable approach, and how we can construct a probabilistic model for the switches by formulating a similar switching LFM as a switching linear dynamic system (SLDS). We illustrate the performance of the proposed methodology in simulated scenarios and apply it to inferring the switching points in GPS data collected from car movement data in urban environment.

Hartikainen, Jouni

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Physical model for the latent heat of fusion  

E-Print Network (OSTI)

The atomic movement induced on melting has to overcome a viscous drag resistance. It is suggested that the latent heat of fusion supplies the required energy for this physical process. The viscosity model introduced here allows computation of the latent heat from viscosity, molar volume, melting temperature, and atomic mass and diameter. The correlation between these parameters and the latent heat of 14 elements with body and face centered cubic structures was exceptional, with the correlation coefficients of 0.97 and 0.95 respectively.

Jozsef Garai

2004-07-15T23:59:59.000Z

22

Intercomparison of Various Surface Latent Heat Flux Fields  

Science Conference Proceedings (OSTI)

The Japanese Ocean Flux Data Sets with use of Remote Sensing Observations (J-OFURO) latent heat flux field is compared with the Hamburg Ocean–Atmosphere Parameters and Fluxes from Satellite Data (HOAPS), the Goddard Satellite-Based Surface ...

Masahisa Kubota; Atsuko Kano; Hidenori Muramatsu; Hiroyuki Tomita

2003-02-01T23:59:59.000Z

23

Global models of document structure using latent permutations  

E-Print Network (OSTI)

We present a novel Bayesian topic model for learning discourse-level document structure. Our model leverages insights from discourse theory to constrain latent topic assignments in a way that reflects the underlying ...

Chen, Harr

24

Sensible and Latent Heat Flux Measurements over the Ocean  

Science Conference Proceedings (OSTI)

This papar presents an extensive act of sensible heat (Reynolds flux and dissipation methods) and latent heat (dissipation method) flux measurements from a stable deep water tower and from ships on the deep sea. Operational difficulties ...

W. G. Large; S. Pond

1982-05-01T23:59:59.000Z

25

Intraseasonal Latent Heat Flux Based on Satellite Observations  

Science Conference Proceedings (OSTI)

Weekly average satellite-based estimates of latent heat flux (LHTFL) are used to characterize spatial patterns and temporal variability in the intraseasonal band (periods shorter than 3 months). As expected, the major portion of intraseasonal ...

Semyon A. Grodsky; Abderrahim Bentamy; James A. Carton; Rachel T. Pinker

2009-09-01T23:59:59.000Z

26

Shallow and Deep Latent Heating Modes over Tropical Oceans Observed with TRMM PR Spectral Latent Heating Data  

Science Conference Proceedings (OSTI)

Three-dimensional distributions of the apparent heat source (Q1) ? radiative heating (QR) estimated from Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (PR) utilizing the spectral latent heating (SLH) algorithm are analyzed. Mass-...

Yukari N. Takayabu; Shoichi Shige; Wei-Kuo Tao; Nagio Hirota

2010-04-01T23:59:59.000Z

27

State Traffic Safety Information - Fatal Crashes Involving Speeding :  

NLE Websites -- All DOE Office Websites (Extended Search)

Illinois (2007-2009) Illinois (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving Speeding : Illinois (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet Usefulness 0 No votes yet

28

State Traffic Safety Information - Fatal Crashes Involving a Large Truck :  

NLE Websites -- All DOE Office Websites (Extended Search)

Hawaii (2007-2009) Hawaii (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving a Large Truck : Hawaii (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet Usefulness 0 No votes yet

29

State Traffic Safety Information - Fatal Crashes Involving a Large Truck :  

NLE Websites -- All DOE Office Websites (Extended Search)

Delaware (2007-2009) Delaware (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving a Large Truck : Delaware (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet Usefulness

30

State Traffic Safety Information - Fatal Crashes Involving Speeding :  

NLE Websites -- All DOE Office Websites (Extended Search)

Hawaii (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving Speeding : Hawaii (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet Usefulness 0 No votes yet

31

State Traffic Safety Information - Fatal Crashes Involving a Large Truck :  

NLE Websites -- All DOE Office Websites (Extended Search)

District of Columbia (2007-2009) District of Columbia (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving a Large Truck : District of Columbia (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility

32

State Traffic Safety Information - Fatal Single Vehicle Crashes : District  

NLE Websites -- All DOE Office Websites (Extended Search)

District District of Columbia (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Single Vehicle Crashes : District of Columbia (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet

33

State Traffic Safety Information - Fatal Crashes Involving Speeding : Iowa  

NLE Websites -- All DOE Office Websites (Extended Search)

Iowa Iowa (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving Speeding : Iowa (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet Usefulness 0 No votes yet

34

State Traffic Safety Information - Fatal Crashes Involving a Large Truck :  

NLE Websites -- All DOE Office Websites (Extended Search)

Indiana (2007-2009) Indiana (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving a Large Truck : Indiana (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet Usefulness

35

State Traffic Safety Information - Fatal Crashes Involving a Large Truck :  

NLE Websites -- All DOE Office Websites (Extended Search)

Idaho (2007-2009) Idaho (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving a Large Truck : Idaho (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet Usefulness 0 No votes yet

36

State Traffic Safety Information - Fatal Crashes Involving Speeding :  

NLE Websites -- All DOE Office Websites (Extended Search)

Kansas (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving Speeding : Kansas (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet Usefulness 0 No votes yet

37

State Traffic Safety Information - Fatal Crashes Involving Speeding : Maine  

NLE Websites -- All DOE Office Websites (Extended Search)

Maine Maine (2007-2009) Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research » Data State Traffic Safety Information - Fatal Crashes Involving Speeding : Maine (2007-2009) Dataset Summary Description The State Traffic Safety Information (STSI) portal is part of the larger Fatality Analysis Reporting System (FARS) Encyclopedia. STSI provides state-by-state traffic safety profiles, including: crash data, lives saved/savable, legislation, economic costs, grant funding, alcohol related crash data, performance measures, and geographic maps of crash data. Tags {geospatial,fatality,crash,data,safety,roadway,vehicle,human,person} Dataset Ratings Overall 0 No votes yet Data Utility 0 No votes yet Usefulness 0 No votes yet

38

Fighting fatalities and injuries: what to expect in 1985  

Science Conference Proceedings (OSTI)

This article describes the measures being taken by safety associations and agencies to reduce fatalities and disabling injuries among coal miners. A survey was conducted among the top 18 coal producing states' agencies and associations and national coal mining associations. The most common causes of fatalities are roof falls, haulage accidents, machinery accidents, and falls from a highwall. Drowning, electrocution, explosion, coal rockbusts, and overconfidence were also reported. Material handling, roof and rib falls, machinery, haulage, and electrical accidents were reported as the most frequent causes of disabling injuries, along with reaching, lifting, pushing, bending, and slips, trips and falls. The survey revealed that most of the largest coal producing states do have active safety programs, and that the states that lack safety program generally have a low fatality rate. Safety programs and materials are available, so it is up to the individual firms and coal miners to use them and to practice safe coal mining.

Erhart, P.P.

1985-03-01T23:59:59.000Z

39

Projecting Fatalities in Crashes Involving Older Drivers, 2000-2025  

Science Conference Proceedings (OSTI)

As part of this research effort, we developed a new methodology for projecting elderly traffic crash fatalities. This methodology separates exposure to crashes from crash risk per se, and further divides exposure into two components, the number of miles driven and the likelihood of being a driver. This component structure permits conceptually different determinants of traffic fatalities to be projected separately and has thorough motivation in behavioral theory. It also permits finer targeting of particular aspects of projections that need improvement and closer linking of projections to possible policy instruments for influencing them.

Hu, P.S.

2001-03-23T23:59:59.000Z

40

THE ANALYSIS OF FATAL ACCIDENTS IN INDIAN D. Sengupta1  

E-Print Network (OSTI)

THE ANALYSIS OF FATAL ACCIDENTS IN INDIAN COAL MINES A. Mandal D. Sengupta1 Indian Statistical of Indian coal mines from April 1989 to March 1998. It is found that Indian mines have considerably higher over 600,000 miners and other workers. Safety in the Indian coal mines is therefore a very important

Mandal, Abhyuday

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

A Small Updraft Producing a Fatal Lightning Flash  

Science Conference Proceedings (OSTI)

Just prior to 1900 UTC 25 July 2000, an 18-year-old male was fatally wounded by a lightning flash on the summit of Pikes Peak, Colorado. This case is believed to be unique in that radar and satellite data indicated that the cell that produced the ...

Stephen Hodanish; Ronald L. Holle; Daniel T. Lindsey

2004-06-01T23:59:59.000Z

42

Design and simulation of latent heat storage units  

DOE Green Energy (OSTI)

This report presents the results of two years of research and development on passive latent heat storage systems. Analytical models have been developed and extended, and a computer code for simulating the performance of a latent heat storage has been developed. The code is intended to be merged into a larger solar energy system simulation code and used for making realistic system studies. Simulation studies using a code which has a flexible and accurate routine for handling the storage subsystem should lead to the development of better systems than those in which storage is added on after the rest of the system has already been selected and optimized.

Shamsundar, N.; Stein, E.; Rooz, E.; Bascaran, E.; Lee, T.C. (Houston Univ., TX (United States))

1992-04-01T23:59:59.000Z

43

Design and simulation of latent heat storage units. Final report  

DOE Green Energy (OSTI)

This report presents the results of two years of research and development on passive latent heat storage systems. Analytical models have been developed and extended, and a computer code for simulating the performance of a latent heat storage has been developed. The code is intended to be merged into a larger solar energy system simulation code and used for making realistic system studies. Simulation studies using a code which has a flexible and accurate routine for handling the storage subsystem should lead to the development of better systems than those in which storage is added on after the rest of the system has already been selected and optimized.

Shamsundar, N.; Stein, E.; Rooz, E.; Bascaran, E.; Lee, T.C. [Houston Univ., TX (United States)

1992-04-01T23:59:59.000Z

44

Atmospheric Latent Heating Distributions in the Tropics Derived from Satellite Passive Microwave Radiometer Measurements  

Science Conference Proceedings (OSTI)

A method for the remote sensing of three-dimensional latent heating distributions in precipitating tropical weather systems from satellite passive microwave observations is presented. In this method, cloud model simulated hydrometeor/latent ...

William S. Olson; Christian D. Kummerow; Ye Hong; Wei-Kuo Tao

1999-06-01T23:59:59.000Z

45

Multi-Scale Kernel Latent Variable Models for Nonlinear Time Series Pattern Matching  

Science Conference Proceedings (OSTI)

In this paper we propose a method for nonlinear time series pattern matching: "Multi-Scale Kernel Latent Variable (MSKLV) models". The pattern matching methodology includes multi-scale analysis using wavelet decomposition of time series and finding latent ...

B. Venkataramana Kini; C. Chandra Sekhar

2008-01-01T23:59:59.000Z

46

Predictive discrete latent factor models for large scale dyadic data  

Science Conference Proceedings (OSTI)

We propose a novel statistical method to predict large scale dyadic response variables in the presence of covariate information. Our approach simultaneously incorporates the effect of covariates and estimates local structure that is induced by interactions ... Keywords: co-clustering, dyadic data, generalized linear regression, latent factor modeling

Deepak Agarwal; Srujana Merugu

2007-08-01T23:59:59.000Z

47

Fast structure learning in generalized stochastic processes with latent factors  

Science Conference Proceedings (OSTI)

Understanding and quantifying the impact of unobserved processes is one of the major challenges of analyzing multivariate time series data. In this paper, we analyze a flexible stochastic process model, the generalized linear auto-regressive process ... Keywords: generalized linear models, latent factors, time series analysis

Mohammad Taha Bahadori, Yan Liu, Eric P. Xing

2013-08-01T23:59:59.000Z

48

Predictive Inference Using Latent Variables with Lynne Steuerle Schofield  

E-Print Network (OSTI)

institutionally-generated PV methodology and find it applies with greater generality than shown previously. When latent proficiency is an independent variable, we show that the standard institu- tional PV methodology with high reliability and precision, due to their efficient use of assessment data. Econometricians, policy

49

Latent Heat Thermal Energy Storage with Embedded Heat Pipes for Concentrating Solar Power Applications.  

E-Print Network (OSTI)

?? An innovative, novel concept of combining heat pipes with latent heat thermal energy storage (LHTES) for concentrating solar power (CSP) applications is explored. The… (more)

Robak, Christopher

2012-01-01T23:59:59.000Z

50

Fatality and Injury Severity of Older Adult Motor Vehicle Collisions in Orange County, California, 1998-2007  

E-Print Network (OSTI)

Report of Fatal and Injury Motor Vehicle Traffic Collisions.of state regulations on motor vehicle fatalities for youngerXIV, NO . 1 : February 2013 motor vehicle traffic crashes.

2013-01-01T23:59:59.000Z

51

The Relationship between Sea Surface Temperature and Latent Heat Flux in the Equatorial Pacific  

Science Conference Proceedings (OSTI)

Moored buoy data from the equatorial Pacific are analyzed to investigate the relationship between sea surface temperature (SST) and latent heat flux from the ocean. It is found that at low SST the latent heat flux increases with SST; at high SST ...

Guang Jun Zhang; Michael J. Mcphaden

1995-03-01T23:59:59.000Z

52

The Effect of Latent Heat Release on the Evolution of a Warm Occluded Thermal Structure  

Science Conference Proceedings (OSTI)

The effect of latent heat release on the development of the occluded thermal structure in a major winter storm is examined through comparison of full physics (FP) and no-latent-heat-release (NLHR) simulations of the event performed using the ...

Derek J. Posselt; Jonathan E. Martin

2004-02-01T23:59:59.000Z

53

Equatorial Waves in the Upper Troposphere and Lower Stratosphere Forced by Latent Heating Estimated from TRMM Rain Rates  

Science Conference Proceedings (OSTI)

Equatorial atmospheric waves in the upper troposphere and lower stratosphere (UTLS), excited by latent heating, are investigated by using a global spectral model. The latent heating profiles are derived from the 3-hourly Tropical Rainfall ...

Jung-Hee Ryu; M. Joan Alexander; David A. Ortland

2011-10-01T23:59:59.000Z

54

Spectral Retrieval of Latent Heating Profiles from TRMM PR Data. Part I: Development of a Model-Based Algorithm  

Science Conference Proceedings (OSTI)

An algorithm, the spectral latent heating (SLH) algorithm, has been developed to estimate latent heating profiles for the Tropical Rainfall Measuring Mission precipitation radar with a cloud-resolving model (CRM). Heating-profile lookup tables ...

Shoichi Shige; Yukari N. Takayabu; Wei-Kuo Tao; Daniel E. Johnson

2004-08-01T23:59:59.000Z

55

The Role of Multiple Vortex Tornado Structure in Causing Storm Researcher Fatalities  

Science Conference Proceedings (OSTI)

A large and violent tornado/multiple vortex mesocyclone (MVMC) / tornado tracked east and northeastward near El Reno, Oklahoma on 31-May-2013, causing eight fatalities, including storm-chasers/researchers attempting to deploy in-situ instrumentation. Sub-...

Joshua Wurman; Karen Kosiba; Paul Robinson; Tim Marshall

56

Spatial and Temporal Analysis of Tornado Fatalities in the United States: 1880–2005  

Science Conference Proceedings (OSTI)

A dataset of killer tornadoes is compiled and analyzed spatially in order to assess region-specific vulnerabilities in the United States from 1880 to 2005. Results reveal that most tornado fatalities occur in the lower–Arkansas, Tennessee, and ...

Walker S. Ashley

2007-12-01T23:59:59.000Z

57

Underestimation of Latent and Sensible Heat Fluxes above the Agulhas Current in NCEP and ECMWF Analyses  

Science Conference Proceedings (OSTI)

The Agulhas Current is the major western boundary current of the Southern Hemisphere. South of Africa it retroflects back into the southwest Indian Ocean, transporting relatively warm water into the midlatitudes. Large sensible and latent heat ...

M. Rouault; C. J. C. Reason; J. R. E. Lutjeharms; A. C. M. Beljaars

2003-02-01T23:59:59.000Z

58

Rectified Wind Forcing and Latent Heat Flux Produced by the Madden–Julian Oscillation  

Science Conference Proceedings (OSTI)

Rectification of (Madden–Julian oscillation) MJO-induced wind speed and latent heat flux variations across the tropical Indian and western Pacific Oceans is estimated using 51 yr of NCEP–NCAR reanalysis. The rectified wind speed anomaly is ...

Toshiaki Shinoda; Harry H. Hendon

2002-12-01T23:59:59.000Z

59

Spatial and temporal distribution of latent heating in the South Asian monsoon region.  

E-Print Network (OSTI)

??Information from the TRMM-CSH and TRMM-2A12 datasets is used to examine the four-dimensional latent heating (LH) structures over the Asian monsoon region between 1998 and… (more)

Zuluaga-Arias, Manuel D.

2009-01-01T23:59:59.000Z

60

A Comparison of Latent Heat Fluxes over Global Oceans for Four Flux Products  

Science Conference Proceedings (OSTI)

The ocean surface latent heat flux (LHF) plays an essential role in global energy and water cycle variability. In this study, monthly LHF over global oceans during 1992–93 are compared among Goddard Satellite-Based Surface Turbulent Fluxes, ...

Shu-Hsien Chou; Eric Nelkin; Joe Ardizzone; Robert M. Atlas

2004-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Latent Heat Release in an Extratropical Cyclone that Developed Explosively over the Southeastern United States  

Science Conference Proceedings (OSTI)

Using the Goddard Laboratory for Atmospheres FGGE Level III-b analyses, the latent heat release (LHR) associated with an extratropical cyclone that deepened explosively over the southeastern United States is investigated. Parameterized LUR was ...

Earl K. Fosdick; Phillip J. Smith

1991-01-01T23:59:59.000Z

62

Precipitation and Latent Heating Characteristics of the Major Tropical Western Pacific Cloud Regimes  

Science Conference Proceedings (OSTI)

An objective tropical cloud regime classification based on daytime averaged cloud-top pressure and optical thickness information from the International Satellite Cloud Climatology Project (ISCCP) is combined with precipitation and latent heating ...

Christian Jakob; Courtney Schumacher

2008-09-01T23:59:59.000Z

63

The Importance of Resolving Mesoscale Latent Heating in the North Atlantic Storm Track  

Science Conference Proceedings (OSTI)

Theoretical, observational, and modeling studies have established an important role for latent heating in midlatitude cyclone development. Models simulate some contribution from condensational heating to cyclogenesis, even with relatively coarse ...

Jeff Willison; Walter A. Robinson; Gary M. Lackmann

2013-07-01T23:59:59.000Z

64

Four-Dimensional Structure of Monthly Latent Heating Derived from SSM/ISatellite Measurements  

Science Conference Proceedings (OSTI)

Time–space distributions of mean monthly latent heating estimated from Special Sensor Microwave/Imager (SSM/I) passive microwave satellite measurements using the Florida State University precipitation profile retrieval algorithm over ocean ...

Song Yang; Eric A. Smith

1999-04-01T23:59:59.000Z

65

The Tropical Dynamical Response to Latent Heating Estimates Derived from the TRMM Precipitation Radar  

Science Conference Proceedings (OSTI)

A 3-yr (1998–2000) climatology of near-surface rainfall and stratiform rain fraction observed by the Tropical Rainfall Measuring Mission (TRMM) precipitation radar (PR) was used to calculate the four-dimensional distribution of tropical latent ...

Courtney Schumacher; Robert A. Houze Jr.; Ian Kraucunas

2004-06-01T23:59:59.000Z

66

Latent and Sensible Heat Flux Anomalies over the Northern Oceans: The Connection to Monthly Atmospheric Circulation  

Science Conference Proceedings (OSTI)

The influence of the atmospheric circulation on monthly anomalies of ocean surface latent and sensible heat fluxes is explored. The fluxes are estimated using bulk formulas applied to a set of about four decades of marine observations over 1946–...

Daniel R. Cayan

1992-04-01T23:59:59.000Z

67

Latent Heating and Mixing Due to Entrainment in Tropical Deep Convection  

Science Conference Proceedings (OSTI)

Recent studies have noted the role of latent heating above the freezing level in reconciling Riehl and Malkus’ Hot Tower Hypothesis (HTH) with evidence of diluted tropical deep convective cores. This study evaluates recent modifications to the HTH ...

Clayton J. McGee; Susan C. van den Heever

68

Mixtures of Gaussians for Uncertainty Description in Bivariate Latent Heat Flux Proxies  

Science Conference Proceedings (OSTI)

This paper proposes a new probabilistic approach for describing uncertainty in the ensembles of latent heat flux proxies. The proxies are obtained from hourly Bowen ratio and satellite-derived measurements, respectively, at several locations in ...

R. Wójcik; Peter A. Troch; H. Stricker; P. Torfs; E. Wood; H. Su; Z. Su

2006-06-01T23:59:59.000Z

69

Evaluation of Latent Heat Flux Fields from Satellites and Models during SEMAPHORE  

Science Conference Proceedings (OSTI)

Latent heat fluxes were derived from satellite observations in the region of Structure des Echanges Mer–Atmosphère, Propriétés des Hétérogénéités Océaniques: Recherche Expérimentale (SEMAPHORE), which was conducted near the Azores islands in the ...

Denis Bourras; W. Timothy Liu; Laurence Eymard; Wenqing Tang

2003-02-01T23:59:59.000Z

70

Non-Quasi-Geostrophic Effects in Baroclinic Waves with Latent Heat Release  

Science Conference Proceedings (OSTI)

A second-order theory of baroclinic waves is developed to investigate non-quasi-geostrophic behavior in disturbances in which latent heat release associated with condensation is permitted to occur in an atmosphere saturated with water vapor. A ...

Chung-Muh Tang; George H. Fichtl

1984-05-01T23:59:59.000Z

71

A Comparison of Sensible and Latent Heat Flux Calculations Using the Bowen Ratio and Aerodynamic Methods  

Science Conference Proceedings (OSTI)

An analysis technique is outlined that calculates the sensible and latent heat fluxes by the Bowen ratio and aerodynamic methods, using profile measurements at any number of heights. Field measurements at two sites near Churchill, Manitoba, ...

David H. Halliwell; Wayne R. Rouse

1989-08-01T23:59:59.000Z

72

Satellite-derived Surface Latent Heat Fluxes in a Rapidly Intensifying Marine Cyclone  

Science Conference Proceedings (OSTI)

The aim of this article is to estimate surface latent heat fluxes in the vicinity of a rapidly deepening cyclone before and during its period of most rapid intensification. This is done with a bulk parameterization scheme and remotely sensed ...

Douglas K. Miller; Kristina B. Katsaros

1992-07-01T23:59:59.000Z

73

Historical analysis of legal opinions with a sparse mixed-effects latent variable model  

Science Conference Proceedings (OSTI)

We propose a latent variable model to enhance historical analysis of large corpora. This work extends prior work in topic modelling by incorporating metadata, and the interactions between the components in metadata, in a general way. To test this, we ...

William Yang Wang; Elijah Mayfield; Suresh Naidu; Jeremiah Dittmar

2012-07-01T23:59:59.000Z

74

Direct and Indirect Effects of Latent Heat Release on a Synoptic-Scale Wave System  

Science Conference Proceedings (OSTI)

The primary goal of this paper is to diagnose, the “direct” and “indirect” effects of latent heat release on a synoptic-scale wave system containing an extratropical cyclone that developed over the eastern United States. To achieve this goal, ...

Patricia M. Pauley; Phillip J. Smith

1988-05-01T23:59:59.000Z

75

Latent Heat Release as a Possible Forcing Mechanism for Atmospheric Tides  

Science Conference Proceedings (OSTI)

The consequences of the hypothesis of Lindzen (1978) that latent heat release may be a significant excitation mechanism for the semidiurnal atmospheric tide are examined in some detail. Harmonic analysis of hourly rainfall data from 79 tropical ...

Kevin Hamilton

1981-01-01T23:59:59.000Z

76

The Role of Latent Heat Release in Baroclinic Waves-Without ?-Effect  

Science Conference Proceedings (OSTI)

In this paper we develop the analytical theory of two-level quasi-geostrophic baroclinic waves without ?-effect aimed at understanding the role of latent heat release on the development of baroclinic waves.

Chung-Muh Tang; George H. Fichtl

1983-01-01T23:59:59.000Z

77

Latent Heat Flux Profiles from Collocated Airborne Water Vapor and Wind Lidars during IHOP_2002  

Science Conference Proceedings (OSTI)

Latent heat flux profiles in the convective boundary layer (CBL) are obtained for the first time with the combination of the Deutsches Zentrum für Luft- und Raumfahrt (DLR) water vapor differential absorption lidar (DIAL) and the NOAA high ...

C. Kiemle; G. Ehret; A. Fix; M. Wirth; G. Poberaj; W. A. Brewer; R. M. Hardesty; C. Senff; M. A. LeMone

2007-04-01T23:59:59.000Z

78

A social demographic study of the likelihood of sustaining an occupational fatality resulting in death  

E-Print Network (OSTI)

This thesis explores occupational fatalities to American males for the years 1998 and 1999. The focus is on predicting the likelihood that the individual will sustain an occupational injury resulting in death based on an occupational status score. Demographic variables measuring Southern residence, race, ethnicity, marital status, education and age were also included in analyses. Research questions include whether or not individuals in higher status occupations are at a decreased risk of sustaining an occupational fatality, and how the demographic variables included effect occupational fatalities. Using data from death certificates allowed me to measure the individual’s occupational status based on their “usual occupation” and find out whether or not differences exist. The thesis involves two analyses, one with the sample comprised of only males between the ages of 25 and 55 and one including only married males between the ages of 25 and 55. Logistic regression is employed as the method of analysis to model the odds of the risk of sustaining an occupational fatality that results in death. The results of the first model found only marital status to be positively and significantly related to occupational fatalities. Black, Hispanic, South and education were found to be negatively related to occupational fatalities. The main hypothesis of this thesis was not supported, however because the regression shows that with each increase on the occupational status index, no significant increase or decrease occurred in sustaining an occupational injury that resulted in death. In the second regression that included only married males, many of the relationships no longer existed. Hispanic and the education variable both lost statistical significance. The only variables to maintain significance were black and South, which were both associated with a decreased risk of sustaining an occupational injury that resulted in death. Problems with the occupational status index as a predictor for the likelihood of sustaining an occupational fatality and restrictions of the data may be the main issue that resulted in a lack of findings.

Traut, Rachel Lynn

2007-05-01T23:59:59.000Z

79

Measuring the Burden of Non-Fatal Illness in Wisconsin Brief Month Year  

E-Print Network (OSTI)

To improve the health of Wisconsin, we need measures of disease burden for both fatal and non-fatal illnesses. This is the fifth in a series of brief reports from work on the “Making Wisconsin the Healthiest State ” project. With funding from the UW School of Medicine and Public Health Wisconsin Partnership Program, our goal for this 4-year project is to identify the most effective investments for Wisconsin to become the nation’s healthiest state with less health disparity. This report examines the availability of data on the morbidity of Wisconsin’s residents and estimates the burden of nonfatal illness. Vol. 2, Number 1

Vol X; Number X; Bridget C. Booske; Patrick L. Remington; David A. Kindig

2007-01-01T23:59:59.000Z

80

Motor Vehicle Crash Fatalities and Injuries: An Analysis of the Relationship of Roadway, Driver, Vehicle Characteristics in Oregon  

E-Print Network (OSTI)

Motor Vehicle Crash Fatalities and Injuries: An Analysis of the Relationship of Roadway, Driver, Vehicle Characteristics in Oregon Motor Vehicle Crash Fatalities and Injuries: An Analysis,000 population among Oregon counties from 2000-2005 ranged from 6.64-211.17. In the event of a severe motor

Bertini, Robert L.

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Fatalities Associated with Nonconvective High-Wind Events in the United States  

Science Conference Proceedings (OSTI)

A database was compiled for the period 1980–2005 to assess the threat to life in the conterminous United States from nonconvective high-wind events. This study reveals the number of fatalities from these wind storms, their cause, and their unique ...

Walker S. Ashley; Alan W. Black

2008-02-01T23:59:59.000Z

82

Avian risk behavior and fatalities at the Altamont Wind Resource Area: March 1998 - February 1999  

DOE Green Energy (OSTI)

Since 1981, more than 7,000 wind turbines have been installed in the Altamont Wind Resource Area in north-central California. Currently, about 5,000 turbines are operating. Past research efforts demonstrated that wind turbines frequently kill birds, especially raptors. Little is known about the specific flight and perching behaviors by birds near wind turbines. A better understanding of these interactions may one day yield insights on how to minimize bird fatalities. This Phase 1 progress report summarizes research findings obtained at 20 study plots totaling 785 turbines of various configurations and conducted between March 1998 and February 1999. The authors examined bird use and behaviors and collected data on fatalities at the same turbines throughout the course of the surveys. They completed 745 30-minute point counts (1,702 bird observations) that quantified bird risk behaviors and bird use of the study plots. The four most frequently observed bird species were red-tailed hawks, common ravens, turkey vultures, and golden eagles. During the same period, the authors recorded 95 bird fatalities. Raptors represent 51% (n=49) of the kills found. The data indicate that the relative abundance of species observed does not predict the relative frequency of fatalities per species. Phase II of the research is underway.

Thelander, C.; Rugge, L.

2000-05-08T23:59:59.000Z

83

Spatially Distributed CO2, Sensible, and Latent Heat Fluxes Over the  

NLE Websites -- All DOE Office Websites (Extended Search)

Spatially Distributed CO2, Sensible, and Latent Heat Fluxes Over the Spatially Distributed CO2, Sensible, and Latent Heat Fluxes Over the Southern Great Plains Berry, Joseph Carnegie Inst.of Washington Riley, William Lawrence Berkeley National Laboratory Biraud, Sebastien Lawrence Berkeley National Laboratory Torn, Margaret Lawrence Berkeley National Laboratory Fischer, Marc Lawrence Berkeley National Laboratory Category: Atmospheric State and Surface Vegetation strongly influences the spatial distribution of surface sensible and latent heat fluxes, and also impacts the ecosystem to atmosphere CO2 exchanges. We describe here a methodology to estimate surface energy fluxes and Net Ecosystem Exchange (NEE) of CO2 continuously over the Southern Great Plains, using (1) data from the Atmospheric Radiation Measurement (ARM) program in Oklahoma and Kansas; (2) meteorological forcing data from

84

Latent Heating and Cooling Rates in Developing and Nondeveloping Tropical Disturbances during TCS-08: Radar-Equivalent Retrievals from Mesoscale Numerical Models and ELDORA  

Science Conference Proceedings (OSTI)

Latent heating and cooling rates have a critical role in predicting tropical cyclone formation and intensification. In a prior study, Park and Elsberry estimated the latent heating and cooling rates from aircraft Doppler radar [Electra Doppler ...

Myung-Sook Park; Andrew B. Penny; Russell L. Elsberry; Brian J. Billings; James D. Doyle

2013-01-01T23:59:59.000Z

85

Spectral Retrieval of Latent Heating Profiles from TRMM PR Data. Part IV: Comparisons of Lookup Tables from Two- and Three-Dimensional Cloud-Resolving Model Simulations  

Science Conference Proceedings (OSTI)

The spectral latent heating (SLH) algorithm was developed to estimate latent heating profiles for the Tropical Rainfall Measuring Mission Precipitation Radar (TRMM PR). The method uses TRMM PR information (precipitation-top height, precipitation ...

Shoichi Shige; Yukari N. Takayabu; Satoshi Kida; Wei-Kuo Tao; Xiping Zeng; Chie Yokoyama; Tristan L’Ecuyer

2009-10-01T23:59:59.000Z

86

Overcoming Network Overload and Redundancy in Interorganizational Networks: The Roles of Potential and Latent Ties  

Science Conference Proceedings (OSTI)

This paper builds on Granovetter's distinction between strong and weak ties [Granovetter, M. S. 1973. The strength of weak ties. Amer. J. Sociol.78(6) 1360–1380] in order to respond ... Keywords: exploration, interorganizational ties, network evolution, network overload, potential and latent ties, redundancy

Francesca Mariotti; Rick Delbridge

2012-03-01T23:59:59.000Z

87

Estimates of Surface Humidity and Latent Heat Fluxes over Oceans from SSM/I Data  

Science Conference Proceedings (OSTI)

Monthly averages of daily latent heat fluxes over the oceans for February and August 1988 are estimated using a stability-dependent bulk scheme. Daily fluxes are computed from daily SSM/I (Special Sensor Microwave/Imager) wind speeds and EOF-...

Shu-Hsien Chou; Robert M. Atlas; Chung-Lin Shie; Joe Ardizzone

1995-08-01T23:59:59.000Z

88

Latent factor models with additive and hierarchically-smoothed user preferences  

Science Conference Proceedings (OSTI)

Items in recommender systems are usually associated with annotated attributes: for e.g., brand and price for products; agency for news articles, etc. Such attributes are highly informative and must be exploited for accurate recommendation. While learning ... Keywords: inference, latent variable models, recomcollaborative filtering, recomfactor models, recommendation

Amr Ahmed; Bhargav Kanagal; Sandeep Pandey; Vanja Josifovski; Lluis Garcia Pueyo; Jeff Yuan

2013-02-01T23:59:59.000Z

89

On the Use of Lower Saturation Criteria for Release of Latent Heat in NWP Models  

Science Conference Proceedings (OSTI)

In several numerical models the large-scale release of latent heat is evaluated when the mixing ratio q exceeds a certain fraction (SATRH < 1) of its saturation value qs. The predicted mixing ratio at the end of a time step in the above case is ...

Mukut B. Mathur

1983-09-01T23:59:59.000Z

90

Latent Community Topic Analysis: Integration of Community Discovery with Topic Modeling  

Science Conference Proceedings (OSTI)

This article studies the problem of latent community topic analysis in text-associated graphs. With the development of social media, a lot of user-generated content is available with user networks. Along with rich information in networks, user graphs ... Keywords: Topic modeling, community discovery

Zhijun Yin; Liangliang Cao; Quanquan Gu; Jiawei Han

2012-09-01T23:59:59.000Z

91

A latent topic extracting method based on events in a document and its application  

Science Conference Proceedings (OSTI)

Recently, several latent topic analysis methods such as LSI, pLSI, and LDA have been widely used for text analysis. However, those methods basically assign topics to words, but do not account for the events in a document. With this background, in this ...

Risa Kitajima; Ichiro Kobayashi

2011-06-01T23:59:59.000Z

92

Recovering latent information in treebanks David Chiang and Daniel M. Bikel  

E-Print Network (OSTI)

Recovering latent information in treebanks David Chiang and Daniel M. Bikel University lexicalized TAG models in (Chiang, 2000; Sarkar, 2001; Chen and Vijay­ Shanker, 2000). Inducing a lexicalized­ searchers investigated this type of extraction to con­ struct stochastic TAG parsers (Chiang, 2000; Chen

Chiang, David

93

The Role of Latent Heat Release in the Evolution of a Weak Extratropical Cyclone  

Science Conference Proceedings (OSTI)

A study of the sensitivity of a weak winter extratropical cyclone to latent heat release (LHR) is presented using 48-h simulations of the cyclone's evolution derived from three versions of the LFM model: a MOIST simulation in which full model ...

John E. Zimmerman; Phillip J. Smith; David R. Smith

1989-05-01T23:59:59.000Z

94

Beyond Networks and Hierarchies: Latent Organizations in the U.K. Television Industry  

Science Conference Proceedings (OSTI)

Since the mid 1980s, organization theorists have highlighted the emergence of the networked model of organization as a response to global competition and pressures for increased market flexibility. Cultural industries have not been immune from this development. ... Keywords: Brokers, Hierarchy, Knowledge, Latent organization, Networks, Television industry, Trust

Ken Starkey; Christopher Barnatt; Sue Tempest

2000-05-01T23:59:59.000Z

95

Environmental Forcing of Supertyphoon Paka’s (1997) Latent Heat Structure  

Science Conference Proceedings (OSTI)

The distribution and intensity of total (i.e., combined stratified and convective processes) rain rate/latent heat release (LHR) were derived for Tropical Cyclone Paka during the period 9–21 December 1997 from the F-10, F-11, F-13, and F-14 ...

Edward Rodgers; William Olson; Jeff Halverson; Joanne Simpson; Harold Pierce

2000-12-01T23:59:59.000Z

96

A Latent-and Sensible-Heat Polynya Model for the North Water, Northern Baffin Bay  

Science Conference Proceedings (OSTI)

The Pease latent-heat polynya model is coupled to a reduced-gravity, coastal upwelling model in order to simulate the formation and maintenance of the North Water (NOW), the Arctic's largest polynya, located in northern Beffin Bay. In this region,...

Lawrence A. Mysak; Fengting Huang

1992-06-01T23:59:59.000Z

97

Snow Temperature Changes within a Seasonal Snowpack and their Relationship to Turbulent Fluxes of Sensible and Latent Heat  

Science Conference Proceedings (OSTI)

Snowpack temperatures from a subalpine forest below Niwot Ridge, Colorado are examined with respect to atmospheric conditions and the 30-min above-canopy and subcanopy eddy covariance fluxes of sensible Qh and latent Qe heat. In the lower snowpack,...

Sean P. Burns; Noah P. Molotch; Mark W. Williams; John F. Knowles; Brian Seok; Russell K. Monson; Andrew A. Turnipseed; Peter D. Blanken

98

The Sensitivity of Latent Heat Flux to Changes in the Radiative Forcing: A Framework for Comparing Models and Observations  

Science Conference Proceedings (OSTI)

A climate model must include an accurate surface physics scheme in order to examine the interactions between the land and atmosphere. Given an increase in the surface radiative forcing, the sensitivity of latent heat flux to available energy ...

Jonathan M. Winter; Elfatih A. B. Eltahir

2010-05-01T23:59:59.000Z

99

Variations of Sensible and Latent Heat Fluxes from a Great Lakes Buoy and Associated Synoptic Weather Patterns  

Science Conference Proceedings (OSTI)

An investigation of sensible and latent heat fluxes and their relation to synoptic weather events was performed using hourly meteorological measurements from National Data Buoy Center buoy 45003, located in northern Lake Huron, during April–...

Neil F. Laird; David A. R. Kristovich

2002-02-01T23:59:59.000Z

100

Estimation of Latent Heating of Rainfall during the Onset of the Indian Monsoon Using TRMM PR and Radiosonde Data  

Science Conference Proceedings (OSTI)

The objective of this study is to estimate the vertical structure of the latent heating of precipitation in the vicinity of the Himalayas. Based on a cloud physics parameterization and the thermodynamic equilibrium equation, a simple algorithm is ...

Ramata Magagi; Ana P. Barros

2004-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Entropy Budget of an Atmosphere in Radiative–Convective Equilibrium. Part II: Latent Heat Transport and Moist Processes  

Science Conference Proceedings (OSTI)

In moist convection, atmospheric motions transport water vapor from the earth's surface to the regions where condensation occurs. This transport is associated with three other aspects of convection: the latent heat transport, the expansion work ...

Olivier Pauluis; Isaac M. Held

2002-01-01T23:59:59.000Z

102

Latent Heating and Cooling Rates in Developing and Nondeveloping Tropical Disturbances during TCS-08: TRMM PR versus ELDORA Retrievals  

Science Conference Proceedings (OSTI)

Unique sets of Electra Doppler Radar (ELDORA) observations in both developing and nondeveloping tropical disturbances in the western North Pacific are used to retrieve latent heating and cooling rates. During the reintensification of Sinlaku, ...

Myung-Sook Park; Russell L. Elsberry

2013-01-01T23:59:59.000Z

103

Comparison between Global Latent Heat Flux Computed from Multisensor (SSM/I and AVHRR) and from In Situ Data  

Science Conference Proceedings (OSTI)

The accurate estimate of the latent heat flux (LHF) is important to understand better the coupling between the atmosphere and the ocean and their respective circulation. In the near future, the availability of satellite-derived datasets over long ...

Didier Jourdan; Catherine Gautier

1995-02-01T23:59:59.000Z

104

The Sensitivity of Latent Heat Flux to Changes in the Radiative Forcing: A Framework for Comparing Models and Observations  

E-Print Network (OSTI)

A climate model must include an accurate surface physics scheme in order to examine the interactions between the land and atmosphere. Given an increase in the surface radiative forcing, the sensitivity of latent heat flux ...

Winter, Jonathan (Jonathan Mark)

105

Assessment of the risk of fatal electric shocks inside a substation and in nearby exposed areas  

SciTech Connect

A simulation approach is elaborated for the risk assessment of fatal electric shocks due to touch and step voltages that are caused inside and around substations by ground faults. The approach suggested takes into account specific effects of ground faults, depending on their location, and various exposures encountered in practice. The fibrillation thresholds and human body impedance values are modelled as random functions to match well with the available experimental data. Several typical cases are analyzed for a substation, as an illustration. The approach developed is intended to serve for a realistic analysis of risks implied by grounding system design of a substation surrounded by exposed areas.

Nahman, J.M. (Belgrade Univ. (Yugoslavia))

1990-10-01T23:59:59.000Z

106

Reducing Bat Fatalities From Interactions with Operating Wind Turbines (Fact Sheet)  

Science Conference Proceedings (OSTI)

One of the biggest advantages of wind energy is that, overall, it has fewer negative impacts on the environment than fossil fuel-generated energy. Most professionals in the wind industry would like to reduce the impact of energy generation on plants, animals, and their habitats. This is why the industry is highly motivated to find out why migrating bats have unexpectedly high fatality rates near operating wind farms. New research has provided quantitative data that indicates barotrauma is not a major cause of bat deaths around operating turbines.

Lawson, M.

2013-11-01T23:59:59.000Z

107

A Fern Fatale - X-ray Absorption Spectroscopy Imaging an Arsenic-Loving  

NLE Websites -- All DOE Office Websites (Extended Search)

Fern Fatale - X-ray Absorption Spectroscopy Imaging of an Arsenic-Loving Fern Fatale - X-ray Absorption Spectroscopy Imaging of an Arsenic-Loving Fern For many people, arsenic is synonymous with poison, so it is perhaps a surprise that some plants, such as the fern Pteris vittata (Figure 1) seem to quite deliberately accumulate large amounts of it. What is more, the plant converts it to the most toxic inorganic form known. How does it do this? First some background; while there is some evidence that arsenic is required for health [1], this is debatable. On the other hand, the poisonous nature of arsenic compounds was understood by the ancient Greeks and Romans, and it has been used throughout history as a homicidal and suicidal agent. It is found in two environmentally common oxy acids; arsenous acid (H3AsO3), and arsenic acid (H3AsO4), whose salts are known as arsenites and arsenates, respectively. Of these, the trivalent arsenic species are the most toxic. The infamous agent of murder is arsenic trioxide (white arsenic or As2O3), which is simply the (reputedly tasteless) anhydride of arsenous acid.

108

Session 1: Fatal Construction Injuries Guiding Construction Injury Research: Data Coupled with Industry  

E-Print Network (OSTI)

of examining current construction injury research, identifying research gaps, and developing a strategic research plan. Through existing injury surveillance data systems, much is known about the leading causes of fatal (falls, motor vehicles, machines, and electrocutions) and nonfatal injury (overexertion, falls, and struck by objects) in the construction industry; however, little research has focused on identifying injury problems for specific subsectors of the construction industry. Research that is focused on specific injury problems and specific types of construction work (e.g., falls during truss installation) may lead more directly to identification of effective interventions than research on general injury categories in the construction industry as a whole (e.g., falls in construction). Three high-risk construction industry sectors (highway and street construction, residential building construction, and roofing and truss installation) were selected based on a review of fatal and nonfatal injury data, the number of workers at risk, current trends in the construction industry, OSHA’s regulatory agenda, an external

Casini V; Furrow K; Hause M; Linn H; Washenitz F

1997-01-01T23:59:59.000Z

109

Development of a Physics of Failure Model and Quantitative Assessment of the Fire Fatality Risk of Compressed Natural Gas Bus Cylinders.  

E-Print Network (OSTI)

??Title of Dissertation: DEVELOPMENT OF A PHYSICS OF FAILURE MODEL AND QUANTITATIVE ASSESSMENT OF THE FIRE FATALITY RISKS OF COMPRESSED NATURAL GAS BUS CYLINDERS The… (more)

Chamberlain, Samuel Seamore

2004-01-01T23:59:59.000Z

110

Indirectly heated fluidized bed biomass gasification using a latent heat ballast  

DOE Green Energy (OSTI)

The objective of this study is to improve the heating value of gas produced during gasification of biomass fuels using an indirectly heated gasifier based on latent heat ballasting. The latent heat ballast consists of lithium fluoride salt encased in tubes suspended in the reactor. The lithium fluoride has a melting point that is near the desired gasification temperature. With the ballast a single reactor operating in a cyclic mode stores energy during a combustion phase and releases it during a pyrolysis phase. Tests were carried out in a fluidized bed reactor to evaluate the concept. The time to cool the reactor during the pyrolysis phase from 1,172 K (1,650 F) to 922 K (1,200 F) increased 102% by use of the ballast system. This extended pyrolysis time allowed 33% more biomass to be gasified during a cycle. Additionally, the total fuel fraction pyrolyzed to produce useful gas increased from 74--80%. Higher heating values of 14.2 to 16.6 MJ/Nm{sup 3} (382--445 Btu/scf) on a dry basis were obtained from the ballasted gasifier.

Pletka, R.; Brown, R.; Smeenk, J. [Iowa State Univ., Ames, IA (United States). Center for Coal and the Environment

1998-12-31T23:59:59.000Z

111

Experimental Research on Solar Assisted Heat Pump Heating System with Latent Heat Storage  

E-Print Network (OSTI)

Based on the status quo that conventional energy sources are more and more reduced and environmental pollution is increasingly serious, this paper presents a new model system of conserving energy and environmental protection, namely, a Solar Assisted Heat Pump Heating System with Latent Heat Storage. In this system, solar energy is the major heat source for a heat pump, and the supplementary heat source is soil. The disagreement in time between the space heat load and heat collected by solar heat collector is solved by latent heat storage. In order to obtain such system running conditions and effects in different heating periods, an experiment has been carried out during the whole heating period in Harbin, China. The experimental results show that this system is much better for heating in initial and late periods than that in middle periods. The average heating coefficient is 6.13 for heating in initial and late periods and 2.94 for heating in middle periods. At the same time, this paper also predicts system running properties in other regions.

Han, Z.; Zheng, M.; Liu, W.; Wang, F.

2006-01-01T23:59:59.000Z

112

A stochastic model of radiation carcinogenesis: Latent time distributions and their properties  

Science Conference Proceedings (OSTI)

A stochastic model of radiation carcinogenesis is proposed that has much in common with the ideas suggested by M. Pike as early as 1966. The model allows one to obtain a parametric family of substochastic-type distributions for the time of tumor latency that provides a description of the rate of tumor development and the number of affected individuals. With this model it is possible to interpret data on tumor incidence in terms of promotion and progression processes. The basic model is developed for a prolonged irradiation at a constant dose rate and includes short-term irradiation as a special case. A limiting form of the latent time distribution for short-term irradiation at high doses is obtained. This distribution arises in the extreme value theory within the random minima framework. An estimate for the rate of convergence to a limiting distributions is given. Based on the proposed latent time distributions, long-term predictions of carcinogenic risk do not call for information about irradiation dose. As shown by computer simulation studies and real data analysis, the parametric estimation of carcinogenic risk appears to be robust to the loss of statistical information caused by the right-hand censoring of time-to-tumor observations. It seems likely that this property, although revealed by means of a purely empirical procedure, may be useful in selecting a model for the practical purpose of risk prediction. 44 refs., 3 figs., 1 tab.

Klebanov, L.V.; Yakovlev, A.Yu. (St. Petersburg Technical Univ. (Russian Federation)); Rachev, S.T. (Univ. of California, Santa Barbara (United States))

1993-01-01T23:59:59.000Z

113

Assessment of Latent Heat Reservoirs for Thermal Management of QCW Laser Diodes  

SciTech Connect

There is great interest in improving the thermal management of laser diodes intended for use as pumps in inertial confinement fusion systems. Laser diode power is currently constrained by heat dissipation in the diodes. Diodes typically dissipate a quantity of heat that is comparable to their optical power output. This heating of the diode junction causes a thermal rollover that prevents the output power from scaling linearly with current drive, and also results in reliability limits due to catastrophic failure at diode mirror facets. For the pulsed, quasi-continuous wave (QCW) operating mode employed for LIFE and certain DOD applications, {approx}5 kW/cm{sup 2} of heat must be removed on timescales of {approx}100{micro}s, which is determined by thermal paths located within {approx}200 {micro}m of the laser junction. For these reasons, QCW thermal management is extremely challenging. Reducing the diode junction temperature enables more efficient operation, reduced thermal chirp, and operation at higher output power without compromised reliability - which improves the diode costs as measured in $/W. We have proposed the use of latent heat reservoirs to improve thermal management of diodes used in pulsed, quasi-continuous wave (QCW) operation. Our basic concept involves placement of a reservoir of low-melting-point metal within a few hundred microns of the laser junction, as in Fig. 1-1. This metal's latent heat of fusion maintains a nearly constant temperature (like a cold plate) in the very near vicinity of the diode junction. This cold reservoir creates large thermal gradients, which in turn are anticipated to drive a large heat flow from the diode. In contrast, conventional QCW devices rely on thermal diffusion into a large solid mass which cannot be held at a fixed temperature, which significantly limits the thermal extraction. Our operational concept involves phase changes within the reservoir during every QCW pulse. During the early portion of the pulse, heating of the diode and its surrounding material initiates melting within the latent heat reservoir. This phase change results in a near-constant reservoir temperature that facilitates heat transfer. During the long ({approx}100 ms) time between QCW pulses, the reservoir metal resolidifies. A simple back-of-the-envelope calculation based on Gallium metal shows that a 50 {micro}m thick Gallium reservoir is sufficient to absorb all heat generated by a 350 {micro}s pulse at 5 kW/cm{sup 2}. While this calculation shows that a latent heat reservoir can provide sufficient capacity to handle the magnitude of heat generated, it does not address the transient change in the diode junction temperature, which depends on details the heat flow into and through the reservoir. For this reason, we undertook a set of numerical experiments to quantitatively assess the impact of latent heat reservoirs on junction temperature. This report documents the results of these simulations.

Deri, B; Kotovsky, J; Spadaccini, C

2010-03-15T23:59:59.000Z

114

Considerations and measurements of latent-heat-storage salts for secondary thermal battery applications  

Science Conference Proceedings (OSTI)

Given its potential benefits, the practicality of using a latent heat-storage material as the basis for a passive thermal management system is being assessed by Chloride Silent Power Ltd. (CSPL) with technical assistance from Beta Power, Inc. and Sandia National Laboratories (SNL). Based on the experience gained in large-scale solar energy storage programs, fused salts were selected as the primary candidates for the heat-storage material. The initial phase of this assessment was directed to an EV battery being designed at CSPL for the ETX-II program. Specific tasks included the identification and characterization of potential fused salts, a determination of placement options for the salts within the battery, and an assessment of the ultimate benefit to the battery system. The results obtained to date for each of these tasks are presented in this paper.

Koenig, A.A.; Braithwaite, J.W.; Armijo, J.R.

1988-05-16T23:59:59.000Z

115

A Framework for Incorporating General Domain Knowledge into Latent Dirichlet Allocation using First-Order Logic  

Science Conference Proceedings (OSTI)

Topic models have been used successfully for a variety of problems, often in the form of application-specific extensions of the basic Latent Dirichlet Allocation (LDA) model. Because deriving these new models in order to encode domain knowledge can be difficult and time-consuming, we propose the Fold-all model, which allows the user to specify general domain knowledge in First-Order Logic (FOL). However, combining topic modeling with FOL can result in inference problems beyond the capabilities of existing techniques. We have therefore developed a scalable inference technique using stochastic gradient descent which may also be useful to the Markov Logic Network (MLN) research community. Experiments demonstrate the expressive power of Fold-all, as well as the scalability of our proposed inference method.

Andrzejewski, D; Zhu, X; Craven, M; Recht, B

2011-01-18T23:59:59.000Z

116

Effects of Cloud Seeding, Latent Heat of Fusion, and Condensate Loading on Cloud Dynamics and Precipitation Evolution: A Numerical Study  

Science Conference Proceedings (OSTI)

This study attempts to isolate the dynamic and microphysical effects of seeding. A two-dimensional, time-dependent cloud model has been used to simulate silver iodide (AgI) seeding of convective clouds. Two major dynamic effects (latent heat of ...

Harold D. Orville; Jeng-Ming Chen

1982-12-01T23:59:59.000Z

117

Improving Latent and Sensible Heat Flux Estimates for the Atlantic Ocean (1988–99) by a Synthesis Approach  

Science Conference Proceedings (OSTI)

A new daily latent and sensible flux product developed at the Woods Hole Oceanographic Institution (WHOI) with 1° × 1° resolution for the Atlantic Ocean (65°S–65°N) for the period from 1988 to 1999 was presented. The flux product was developed by ...

Lisan Yu; Robert A. Weller; Bomin Sun

2004-01-01T23:59:59.000Z

118

National Melanoma/Skin Cancer Detection  

E-Print Network (OSTI)

The American Academy of Dermatology (AAD) has designated May as National Melanoma/Skin Cancer Detection and Prevention Month. In 1996, an estimated 1 million cases of skin cancer will be diagnosed, of which approximately 95 % will be squamous cell or basal cell carcinomas (1). Although the incidence of melanoma is lower than those of squamous cell and basal cell carcinomas, the case-fatality rate is highest for persons with melanoma. During 1973–1992, mortality from melanoma increased 34%—the third highest increase of all cancers (2). CDC, in collaboration with the AAD, has initiated the National Skin Cancer Prevention Education Program (NSCPEP) to increase public awareness about skin cancer and to help reduce the occurrence of and deaths associated with skin cancer. Goals of this program are to develop and disseminate educational messages for children, their parents, and other caregivers; develop guidelines for school curricula; evaluate the utility and value of the ultraviolet (UV) index; and develop educational messages for health-care providers. Additional information about this month and the NSCPEP is available from

Among Children; Young Adults

1996-01-01T23:59:59.000Z

119

Heat Transfer and Latent Heat Storage in Inorganic Molten Salts for Concentrating Solar Power Plants  

Science Conference Proceedings (OSTI)

A key technological issue facing the success of future Concentrating Solar Thermal Power (CSP) plants is creating an economical Thermal Energy Storage (TES) system. Current TES systems use either sensible heat in fluids such as oil, or molten salts, or use thermal stratification in a dual-media consisting of a solid and a heat-transfer fluid. However, utilizing the heat of fusion in inorganic molten salt mixtures in addition to sensible heat , as in a Phase change material (PCM)-based TES, can significantly increase the energy density of storage requiring less salt and smaller containers. A major issue that is preventing the commercial use of PCM-based TES is that it is difficult to discharge the latent heat stored in the PCM melt. This is because when heat is extracted, the melt solidifies onto the heat exchanger surface decreasing the heat transfer. Even a few millimeters of thickness of solid material on heat transfer surface results in a large drop in heat transfer due to the low thermal conductivity of solid PCM. Thus, to maintain the desired heat rate, the heat exchange area must be large which increases cost. This project demonstrated that the heat transfer coefficient can be increase ten-fold by using forced convection by pumping a hyper-eutectic salt mixture over specially coated heat exchanger tubes. However,only 15% of the latent heat is used against a goal of 40% resulting in a projected cost savings of only 17% against a goal of 30%. Based on the failure mode effect analysis and experience with pumping salt at near freezing point significant care must be used during operation which can increase the operating costs. Therefore, we conclude the savings are marginal to justify using this concept for PCM-TES over a two-tank TES. The report documents the specialty coatings, the composition and morphology of hypereutectic salt mixtures and the results from the experiment conducted with the active heat exchanger along with the lessons learnt during experimentation.

Mathur, Anoop [Terrafore Inc.] [Terrafore Inc.

2013-08-14T23:59:59.000Z

120

Modeling threat assessments of water supply systems using markov latent effects methodology.  

SciTech Connect

Recent amendments to the Safe Drinking Water Act emphasize efforts toward safeguarding our nation's water supplies against attack and contamination. Specifically, the Public Health Security and Bioterrorism Preparedness and Response Act of 2002 established requirements for each community water system serving more than 3300 people to conduct an assessment of the vulnerability of its system to a terrorist attack or other intentional acts. Integral to evaluating system vulnerability is the threat assessment, which is the process by which the credibility of a threat is quantified. Unfortunately, full probabilistic assessment is generally not feasible, as there is insufficient experience and/or data to quantify the associated probabilities. For this reason, an alternative approach is proposed based on Markov Latent Effects (MLE) modeling, which provides a framework for quantifying imprecise subjective metrics through possibilistic or fuzzy mathematics. Here, an MLE model for water systems is developed and demonstrated to determine threat assessments for different scenarios identified by the assailant, asset, and means. Scenario assailants include terrorists, insiders, and vandals. Assets include a water treatment plant, water storage tank, node, pipeline, well, and a pump station. Means used in attacks include contamination (onsite chemicals, biological and chemical), explosives and vandalism. Results demonstrated highest threats are vandalism events and least likely events are those performed by a terrorist.

Silva, Consuelo Juanita

2006-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
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to obtain the most current and comprehensive results.


121

Spectral Retrieval of Latent Heating Profiles from TRMM PR Data. Part II: Algorithm Improvement and Heating Estimates over Tropical Ocean Regions  

Science Conference Proceedings (OSTI)

The spectral latent heating (SLH) algorithm was developed for the Tropical Rainfall Measuring Mission (TRMM) precipitation radar (PR) in Part I of this study. The method uses PR information [precipitation-top height (PTH), precipitation rates at ...

Shoichi Shige; Yukari N. Takayabu; Wei-Kuo Tao; Chung-Lin Shie

2007-07-01T23:59:59.000Z

122

Moisture Budget Analysis of TOGA COARE Area Using SSM/I-Retrieved Latent Heating and Large-Scale Q2 Estimates  

Science Conference Proceedings (OSTI)

This study addresses the retrieval of tropical open-ocean latent heating using Special Sensor Microwave Imager (SSM/I) satellite measurements. The analysis is carried out for the Tropical Ocean and Global Atmosphere Coupled Ocean–Atmosphere ...

Song Yang; Eric A. Smith

1999-06-01T23:59:59.000Z

123

A Latent Heat Retrieval and Its Effects on the Intensity and Structure Change of Hurricane Guillermo (1997). Part I: The Algorithm and Observations  

Science Conference Proceedings (OSTI)

Despite the fact that latent heating in cloud systems drives many atmospheric circulations, including tropical cyclones, little is known of its magnitude and structure, largely because of inadequate observations. In this work, a reasonably high-...

Stephen R. Guimond; Mark A. Bourassa; Paul D. Reasor

2011-08-01T23:59:59.000Z

124

A Latent Heat Retrieval and Its Effects on the Intensity and Structure Change of Hurricane Guillermo (1997). Part II: Numerical Simulations  

Science Conference Proceedings (OSTI)

In Part I of this study, a new algorithm for retrieving the latent heat field in tropical cyclones from airborne Doppler radar was presented and fields from rapidly intensifying Hurricane Guillermo (1997) were shown. In Part II, the usefulness and ...

Stephen R. Guimond; Jon M. Reisner

2012-11-01T23:59:59.000Z

125

Mean and Variability of the WHOI Daily Latent and Sensible Heat Fluxes at In Situ Flux Measurement Sites in the Atlantic Ocean  

Science Conference Proceedings (OSTI)

Daily latent and sensible heat fluxes for the Atlantic Ocean from 1988 to 1999 with 1° × 1° resolution have been recently developed at Woods Hole Oceanographic Institution (WHOI) by using a variational object analysis approach. The present study ...

Lisan Yu; Robert A. Weller; Bomin Sun

2004-06-01T23:59:59.000Z

126

An Error Analysis of the Thornthwaite-Holzman Equations for Estimating Sensible and Latent Heat Fluxes over Crop and Forest Canopies  

Science Conference Proceedings (OSTI)

Computations of sensible and latent heat fluxes over forest and crop canopies using the Thornthwaite-Holzman equations require an a priori knowledge of roughness and data displacement heights. If the values of these parameters are not ...

O. E. Thompson; R. T. Pinker

1981-03-01T23:59:59.000Z

127

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

128

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

129

Testing executive function models of ADHD and its comorbid conditions: A latent variable approach  

E-Print Network (OSTI)

Current theoretical models of ADHD (i.e., Disinhibition Model: Barkley, 1997; Working Memory Model: Rapport et al., 2001) conceptualize ADHD as the disorder of executive function (EF) with some variation in their emphases on particular components of the broadly-defined EF (e.g., working memory vs. inhibition) and in their postulated relationships with ADHD symptoms. Although these models provide systematic accounts of the manifestation of ADHD, they have not been extensively tested from an empirical standpoint. Moreover, despite the fact that ADHD is highly comorbid with other additional conditions such as learning and behavioral problems and EF deficits are found in individuals with these conditions as well as in those with ADHD, current EF models have not specified the developmental relationship between ADHD and its comorbid conditions. This study was: (1) to examine the extent to which two current models of ADHD are supported in a sample of 102 adults; (2) to present an ??integrated?? model by combining two current models of ADHD and linking them to recent research findings on two common comorbid conditions with ADHD (i.e., reading difficulty and substance abuse); and (3) to test and revise such an integrated model in the light of data using a latent variable analysis. Major findings provided a strong support for the Working Memory Model with a lesser degree of support for the Disinhibition Model. Preliminary evidence of working memory as the primary deficit in ADHD was also obtained in the present sample. Finally, the integrated EF model and its revised model (final model) demonstrated a very good fit to the data. These findings suggest that the integrated model provides a unified account of how EF deficits contribute to the manifestation of ADHD symptoms and comorbid conditions with ADHD. Given some limitations (e.g., sample size and scope) of the present study, current findings need to be replicated.

Lee, Dong Hyung

2004-08-01T23:59:59.000Z

130

From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory  

Science Conference Proceedings (OSTI)

In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

Martineau, Rebecca M [Los Alamos National Laboratory

2012-07-26T23:59:59.000Z

131

Bird Risk Behaviors and Fatalities at the Altamont Pass Wind Resource Area: Period of Performance, March 1998--December 2000  

SciTech Connect

It has been documented that wind turbine operations at the Altamont Pass Wind Resource Area kill large numbers of birds of multiple species, including raptors. We initiated a study that integrates research on bird behaviors, raptor prey availability, turbine design, inter-turbine distribution, landscape attributes, and range management practices to explain the variation in avian mortality at two levels of analysis: the turbine and the string of turbines. We found that inter-specific differences in intensities of use of airspace within close proximity did not explain the variation in mortality among species. Unique suites of attributes relate to mortality of each species, so species-specific analyses are required to understand the factors that underlie turbine-caused fatalities. We found that golden eagles are killed by turbines located in the canyons and that rock piles produced during preparation of the wind tower laydown areas related positively to eagle mortality, perhaps due to the use of these rock piles as cover by desert cottontails. Other similar relationships between fatalities and environmental factors are identified and discussed. The tasks remaining to complete the project are summarized.

Thelander, C. G.; Smallwood, K. S.; Rugge, L.

2003-12-01T23:59:59.000Z

132

Disaggregating Cooling Energy Use of Commercial Buildings Into Sensible and Latent Fractions From Whole-Building Monitored Data: Methodology and Advantages  

E-Print Network (OSTI)

In hot and humid climates, where summers are both warm and humid, the latent cooling can be a significant portion of the total cooling load (as much as 40%). Typically the monitored data only includes whole-building heating and cooling energy use and total electric consumption. A method to disaggregate the latent cooling energy use from the measured whole-building heating and cooling energy use would be of particular interest. This paper presents such a method and discusses its benefits. It is shown that the overall heat transfer coefficient including the conduction, infiltration, and ventilation effects of a building, can be evaluated. Subsequently this enables the disaggregation of the total cooling energy use into sensible and latent cooling fractions. The benefits of such a method include: (i) better understanding of the sensible and latent fractions in the total cooling energy use of a building, and (ii) better regression models for energy analysis. In addition to the whole-building cooling and heating energy use and the ambient conditions, the required system parameters include: (i) cold deck supply temperature, (ii) hot deck supply temperature, (iii) mixed air temperature or ventilation rate, (iv) internal gains, and (v) total mass flow rate of the dual duct constant volume system. If continuous measurements of the system parameters are not available, then one-time measurements may be used to disaggregate the latent cooling energy use.

Katipamula, S.; Reddy, T. A.; Claridge, D. E.

1992-05-01T23:59:59.000Z

133

Webinar on Improving Methods for Estimating Fatality of Birds and Bats at Wind Energy Facilities 10Noon Pacific Wednesday, September 26, 2012  

E-Print Network (OSTI)

Webinar on Improving Methods for Estimating Fatality of Birds and Bats at Wind Energy Facilities 10 results from a California Wind Energy Association (CalWEA)sponsored, California Energy Commissionfunded associated with wind energy facilities, including an improved equation developed to adjust mortality

134

Candidate chemical systems for air cooled, solar powered, absorption air conditioner design. Part II. Solid absorbents, high latent heat refrigerants  

DOE Green Energy (OSTI)

Work done in attempting to qualify absorption refrigeration systems based on refrigerants with intermediate latent heats of vaporization is summarized. In practice, these comprise methanol, ammonia, and methylamine. A wide variety of organic substances, salts, and mixtures were evaluated in as systematic a manner as possible. Several systems of interest are described. The system, LiClO/sub 3/--LiBr--H/sub 2/O, is a good back up system to our first choice of an antifreeze additive system, and thermodynamically promising but subject to some inconvenient materials limitations. The system, LiBr/ZnBr/sub 2/--methanol, is thermodynamically promising but requires additional kinetic qualification. Chemical stability of the system, LiCNS--ammonia/methylamine with various other third components, does not appear to be adequate for a long-lived system.

Biermann, W. J.

1978-04-01T23:59:59.000Z

135

Comparisons of sensible and latent heat fluxes using surface and aircraft data over adjacent wet and dry surfaces  

SciTech Connect

In June 1991, a field study of surface fluxes of latent and sensible heat over heterogeneous surfaces was carried out near Boardman, Oregon (Doran et al., 1992). The object of the study was to develop improved methods of extrapolating from local measurements of fluxes to area-averaged values suitable for use in general circulation models (GCMs) applied to climate studies. A grid element in a GCM is likely to encompass regions whose fluxes vary significantly from one surface type to another. The problem of integrating these fluxes into a single, representative value for the whole element is not simple, and describing such a flux in terms of flux-gradient relationships, as is often done, presents additional difficulties.

Doran, J.C.; Hubbe, J.M.; Shaw, W.J. (Pacific Northwest Lab., Richland, WA (United States)); Baldocchi, D.D.; Crawford, T.L.; Dobosy, R.J.; Meyers, T.J. (National Oceanic and Atmospheric Administration, Oak Ridge, TN (United States). Air Resources Lab. Atmospheric Turbulence and Diffusion Div.)

1992-01-01T23:59:59.000Z

136

Latent Heat Flux and Canopy Conductance Based on Penman–Monteith, Priestley–Taylor Equation, and Bouchet’s Complementary Hypothesis  

Science Conference Proceedings (OSTI)

A novel method is presented to analytically resolve the terrestrial latent heat flux (?E) and conductances (boundary layer gB and surface gS) using net radiation (RN), ground heat flux (G), air temperature (Ta), and relative humidity (RH). This ...

Kaniska Mallick; Andrew Jarvis; Joshua B. Fisher; Kevin P. Tu; Eva Boegh; Dev Niyogi

2013-04-01T23:59:59.000Z

137

A Model for the Influence of Wind and Oceanic Currents on the Size of a Steady-State Latent Heat Coastal Polynya  

Science Conference Proceedings (OSTI)

This paper presents a model for determining the size and shape of a steady-state latent heat coastal polynya in terms of the following free parameters: 1) the frazil ice production rate (F); 2) the wind stress (?); 3) the surface ocean velocity ...

A. J. Willmott; M. A. Morales Maqueda; M. S. Darby

1997-10-01T23:59:59.000Z

138

The Role of Low-Level Moisture Convergence and Ocean Latent Heat Fluxes in the Madden and Julian Oscillation: An Observational Analysis Using ISCCP Data and ECMWF Analyses  

Science Conference Proceedings (OSTI)

This paper examines whether or not low-level moisture convergence and surface latent heat flux act as forcing mechanisms of the Madden and Julian oscillation (MJO), as it is proposed by the theories of wave-CISK (conditional instability of the ...

Charles Jones; Bryan C. Weare

1996-12-01T23:59:59.000Z

139

Validation of Satellite-Derived Daily Latent-Heat Flux over the South China Sea, Compared with Observations and Five Products  

Science Conference Proceedings (OSTI)

We have developed the South China Sea (SCS) daily satellite-derived latent-heat flux (SCSSLH) for the period of 1998 to 2011 at 0.25°×0.25° resolution using data mainly from the Tropical Rain Measuring Mission (TRMM) Microwave Imager (TMI). Flux-...

Dongxiao Wang; Lili Zeng; Xixi Li; Ping Shi

140

Numerical Simulation of a Latent Heat Storage System of a Solar-Aided Ground Source Heat Pump  

E-Print Network (OSTI)

In this study, the rectangular phase change storage tank (PCST) linked to a solar-aided ground source heat pump (SAGSHP) system is investigated experimentally and theoretically. The container of the phase change material (PCM) is the controlling unit of the phase change heat transfer model. It was solved numerically by an enthalpy-based finite difference method and was validated by experimental data. CaCl2•6H2O was used as the PCM in the latent heat storage system of SAGSHP system. In the tank, the PCMs are encapsulated in plastic kegs that are setting on the serpentine coil. The experiments were performed from March 12 to April 10, 2004 in the heating season of the transition period. In order to reflect the effects of the system, two days were chosen to compare the numerical results with experimental data. The inlet and outlet temperature of the water in the PCST, temperature of PCM and storage and emission heat of PCST were measured. The trends of the variation of numerical results and experimental data were in close agreement. Numerical results can reflect the operation mode of the system very well.

Wang, F.; Zheng, M.; Li, Z.; Lei, B.

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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142

Cancer in Australia  

E-Print Network (OSTI)

statistics and information agency. The Institute’s mission is better health and wellbeing for Australians through better health and welfare statistics and information. The Australasian Association of Cancer Registries (AACR) is a collaborative body representing state and territory cancer registries in Australia and New Zealand. Most are members of the International Association of Cancer Registries. The AACR was formed in November 1982 to provide a formal mechanism for promoting uniformity of collection, classification and collation of cancer data. The objectives of the AACR are to: • Achieve national agreement on cancer-specific data definitions and coding and to encourage compliance with such agreements. As far as possible, data definitions and coding should be consistent with existing International Association of Cancer Registries (IACR) protocols and conventions. Facilitate the production of Australian, state and territory and national statistical publications on cancer that are comparable with each other and with international statistical publications. Improve the operational efficiency, and data completeness and quality, of the state and territory and New Zealand cancer registries through collaborative sharing of information. Contribute to national cancer control development in Australia and New Zealand through the regular and timely publication of local and national cancer statistics and the provision of data for cancer control research and health promotion. Contribute national data to international publications of the IACR. Contribute to international cancer coding and statistical analysis developments via members ’ involvement with IACR. Facilitate national epidemiological research projects on cancer (given appropriate local and AIHW ethics committee approvals).CANCER SERIES Number 28

unknown authors

2004-01-01T23:59:59.000Z

143

Cancer Due to Prolonged Inflammation  

E-Print Network (OSTI)

Development. Molecular Cancer Research 4.221 (2006): 5-261.direction of future cancer research is to better understand

Lingampalli, Nithya

2013-01-01T23:59:59.000Z

144

Shark cartilage and cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

speculation in the past that there may be some factor in shark's cartilage that prevents cancer, recent research by the National Cancer Institute could not confirm this, and there...

145

Soy and breast cancer  

Science Conference Proceedings (OSTI)

Are soy foods safe for breast cancer patients? Soy is a rich source of isoflavones (primarily genistein, daidzein, and glycitein). The standard oral therapy undertaken after initial treatment (known as “adjuvant therapy”) for estrogen-sensitive cancers is

146

Sensible and Latent Cooling Load Control Using Centrally-Ducted, Variable-Capacity Space Conditioning Systems in Low Sensible Load Environments  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Sensible and Latent Cooling Load Control Using Centrally-Ducted, Variable-Capacity Space Conditioning Systems in Low Sensible Load Environments James Cummings BA-PIRC; Florida Solar Energy Center Presented at BA Summer Meeting, July 26, 2012 The gist of my message * Fixed capacity AC systems generally provide good RH control in typical residences. * In low-load homes, they may be less effective in achieving good RH control. * On the other hand, variable capacity AC systems have several characteristics which can provide improved RH control in homes. - Both Nordyne and Carrier have variable capacity units, varying from about 40% to 100% of nominal full capacity. - What is variable capacity? -- condenser fan, compressor speed, and AHU fan speed. The gist, continued

147

ENVIRONMENTAL CANCER RISK  

E-Print Network (OSTI)

This report is submitted to the President of the United States in fulfillment of the obligations of the President’s Cancer Panel to appraise the National Cancer Program as established in accordance with the National Cancer Act of 1971 (P.L. 92-218), the

Margaret L. Kripke, Ph.D.; Abby B. S, Ph.D.; Suzanne H. Reuben

2010-01-01T23:59:59.000Z

148

Defining the Critical Hurdles in Cancer Immunotherapy  

E-Print Network (OSTI)

Australia. Ovarian Cancer Research Center, University ofal: New models for cancer research: human cancer stem cellAmerican Association for Cancer Research 2010, 16:2861-71.

2011-01-01T23:59:59.000Z

149

Intraoperative Radiotherapy for Parotid Cancer: A Single-Institution Experience  

Science Conference Proceedings (OSTI)

Purpose: Our practice policy has been to provide intraoperative radiotherapy (IORT) at resection to patients with head-and-neck malignancies considered to be at high risk of recurrence. The purpose of the present study was to review our experience with the use of IORT for primary or recurrent cancer of the parotid gland. Methods and Materials: Between 1982 and 2007, 96 patients were treated with gross total resection and IORT for primary or recurrent cancer of the parotid gland. The median age was 62.9 years (range, 14.3-88.1). Of the 96 patients, 33 had previously undergone external beam radiotherapy as a component of definitive therapy. Also, 34 patients had positive margins after surgery, and 40 had perineural invasion. IORT was administered as a single fraction of 15 or 20 Gy with 4-6-MeV electrons. The median follow-up period was 5.6 years. Results: Only 1 patient experienced local recurrence, 19 developed regional recurrence, and 12 distant recurrence. The recurrence-free survival rate at 1, 3, and 5 years was 82.0%, 68.5%, and 65.2%, respectively. The 1-, 3-, and 5-year overall survival rate after surgery and IORT was 88.4%, 66.1%, and 56.2%, respectively. No perioperative fatalities occurred. Complications developed in 26 patients and included vascular complications in 7, trismus in 6, fistulas in 4, radiation osteonecrosis in 4, flap necrosis in 2, wound dehiscence in 2, and neuropathy in 1. Of these 26 patients, 12 had recurrent disease, and 8 had undergone external beam radiotherapy before IORT. Conclusions: IORT results in effective local disease control at acceptable levels of toxicity and should be considered for patients with primary or recurrent cancer of the parotid gland.

Zeidan, Youssef H., E-mail: youssefzaidan@gmail.com [Department of Radiation Oncology, Methodist Hospital, Indianapolis, IN (United States); Shiue, Kevin; Weed, Daniel [Department of Radiation Oncology, Methodist Hospital, Indianapolis, IN (United States); Johnstone, Peter A. [Department of Radiation Oncology, Indiana University, Indianapolis, IN (United States); Terry, Colin [Methodist Research Institute, Methodist Hospital, Indianapolis, IN (United States); Freeman, Stephen; Krowiak, Edward; Borrowdale, Robert; Huntley, Tod [CENTA Otolaryngology, Indianapolis, IN (United States); Yeh, Alex [Department of Radiation Oncology, Methodist Hospital, Indianapolis, IN (United States)

2012-04-01T23:59:59.000Z

150

Cancer survivorship : understanding the issues faced by cancer survivors.  

E-Print Network (OSTI)

??International research on cancer survivorship has started to identify a range of issues that affect cancer survivors physically, mentally, emotionally and spiritually. These issues can… (more)

Hayward, Penelope Anne

2010-01-01T23:59:59.000Z

151

Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk  

E-Print Network (OSTI)

Family Institute for Breast Cancer Research Ontario CancerInternational Agency for Research on Cancer, 2000. CancerThe Canadian Cancer Registries Epidemiology Research Group,

2009-01-01T23:59:59.000Z

152

Northeast Regional Cancer Institute's Cancer Surveillance and Risk Factor Program  

Science Conference Proceedings (OSTI)

OBJECTIVES The Northeast Regional Cancer Institute is conducting a program of ongoing epidemiologic research to address cancer disparities in northeast Pennsylvania. Of particular concern are disparities in the incidence of, stage at diagnosis, and mortality from colorectal cancer. In northeast Pennsylvania, age-adjusted incidence and mortality rates for colorectal cancer are higher, and a significantly smaller proportion of new colorectal cancer cases are diagnosed with local stage disease than is observed in comparable national data. Further, estimates of the prevalence of colorectal cancer screening in northeast Pennsylvania are lower than the US average. The Northeast Regional Cancer Institute’s research program supports surveillance of common cancers, investigations of cancer risk factors and screening behaviors, and the development of resources to further cancer research in this community. This project has the following specific objectives: I. To conduct cancer surveillance in northeast Pennsylvania. a. To monitor incidence and mortality for all common cancers, and colorectal cancer, in particular, and b. To document changes in the stage at diagnosis of colorectal cancer in this high-risk, underserved community. II. To conduct a population-based study of cancer risk factors and screening behavior in a six county region of northeast Pennsylvania. a. To monitor and document changes in colorectal cancer screening rates, and b. To document the prevalence of cancer risk factors (especially factors that increase the risk of colorectal cancer) and to identify those risk factors that are unusually common in this community. APPROACH Cancer surveillance was conducted using data from the Northeast Regional Cancer Institute’s population-based Regional Cancer Registry, the Pennsylvania Cancer Registry, and NCI’s SEER program. For common cancers, incidence and mortality were examined by county within the region and compared to data for similar populations in the US. For colorectal cancer, the stage at diagnosis of cases diagnosed in northeast Pennsylvania was compared to data from prior years. A population-based interview study of healthy adults was conducted to document the status of cancer screening and to estimate the prevalence of established cancer risk factors in this community. This study is similar in design to that used by the Centers for Disease Control and Prevention’s (CDC) Behavioral Risk Factor Surveillance System (BRFSS). EXPERIMENTAL METHODS AND PROCEDURES: This program includes two distinct but related projects. The first project uses existing data to conduct cancer surveillance in northeast Pennsylvania, and the second is a population-based study of cancer risk factors and cancer screening behaviors in this same population. HUMAN SUBJECTS CONSIDERATIONS This program includes two projects: cancer surveillance and a population-based study of cancer risk factors and screening behavior. The cancer surveillance project involves only the use of existing aggregate data or de-identified data. As such, the surveillance project is exempt from human subjects considerations. The study of cancer risk factors and screening behaviors includes data from a random sample of adult residents of northeast Pennsylvania who are 18 or more years of age. All races, ethnicities and both sexes are included in proportion to their representation in the population. Subjects are interviewed anonymously by telephone; those who are unable to complete an interview in English are ineligible. This project has been reviewed and approved by the Scranton-Temple Residency Program IRB (IRB00001355), which is the IRB for the Northeast Regional Cancer Institute.

Lesko, Samuel M.

2007-07-31T23:59:59.000Z

153

Proteomics for cancer biomarker discovery  

E-Print Network (OSTI)

Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, ...

Volchenboum, Samuel Louis

2007-01-01T23:59:59.000Z

154

Animal Models in Cancer Research  

Science Conference Proceedings (OSTI)

Cancer is a disorder that results in inappropriate growth of cells in the wrong place and at the wrong time. Most frequently cancer arises in older individuals and becomes problematic as it grows large enough to interrupt normal organ function, invades adjacent normal tissues disrupting their function, and spreads to other sites in the body, metastatic sites, where it causes further disabilities. Cancer arises in normal cells of our body. The environmental causes of cancer include numerous, disparate fac...

2009-12-17T23:59:59.000Z

155

Assessment of the risk of transporting spent nuclear fuel by truck  

SciTech Connect

The assessment includes the risks from release of spent fuel materials and radioactive cask cavity cooling water due to transportation accidents. The contribution to the risk of package misclosure and degradation during normal transport was also considered. The results of the risk assessment have been related to a time in the mid-1980's, when it is projected that nuclear plants with an electrical generating capacity of 100 GW will be operating in the U.S. For shipments from reactors to interim storage facilities, it is estimated that a truck carrying spent fuel will be involved in an accident that would not be severe enough to result in a release of spent fuel material about once in 1.1 years. It was estimated that an accident that could result in a small release of radioactive material (primarily contaminated cooling water) would occur once in about 40 years. The frequency of an accident resulting in one or more latent cancer fatalities from release of radioactive materials during a truck shipment of spent fuel to interim storage was estimated to be once in 41,000 years. No accidents were found that would result in acute fatalities from releases of radioactive material. The risk for spent fuel shipments from reactors to reprocessing plants was found to be about 20% less than the risk for shipments to interim storage. Although the average shipment distance for the reprocessing case is larger, the risk is somewhat lower because the shipping routes, on average, are through less populated sections of the country. The total risk from transporting 180-day cooled spent fuel by truck in the reference year is 4.5 x 10/sup -5/ fatalities. An individual in the population at risk would have one chance in 6 x 10/sup 11/ of suffering a latent cancer fatality from a release of radioactive material from a truck carrying spent fuel in the reference year. (DLC)

Elder, H.K.

1978-11-01T23:59:59.000Z

156

Cancer in atomic bomb survivors  

SciTech Connect

This book presents information on the following topics: sampling of atomic bomb survivors and method of cancer detection in Hiroshima and Nagasaki; atomic bomb dosimetry for epidemiological studies of survivors in Hiroshima and Nagasaki; tumor and tissue registries in Hiroshima and Nagasaki; the cancer registry in Nagasaki, with atomic bomb survivor data, 1973-1977; cancer mortality; methods for study of delayed health effects of a-bomb radiation; experimental radiation carcinogenesis in rodents; leukemia, multiple myeloma, and malignant lymphoma; cancer of the thyroid and salivary glands; malignant tumors in atomic bomb survivors with special reference to the pathology of stomach and lung cancer; colorectal cancer among atomic bomb survivors; breast cancer in atomic bomb survivors; and ovarian neoplasms in atomic bomb survirors.

Shigematsu, I.; Kagan, A.

1986-01-01T23:59:59.000Z

157

Aging Impacts Transcriptome but not Genome of Hormone-dependent Breast Cancers  

E-Print Network (OSTI)

and Cancer Interface. Cancer Research 2007, Geigl JB, LangerBreast Cancer Research This Provisional PDF corresponds tobreast cancers Breast Cancer Research 2007, 9:R59 doi:

2007-01-01T23:59:59.000Z

158

Accelerators for Cancer Therapy  

DOE R&D Accomplishments (OSTI)

The vast majority of radiation treatments for cancerous tumors are given using electron linacs that provide both electrons and photons at several energies. Design and construction of these linacs are based on mature technology that is rapidly becoming more and more standardized and sophisticated. The use of hadrons such as neutrons, protons, alphas, or carbon, oxygen and neon ions is relatively new. Accelerators for hadron therapy are far from standardized, but the use of hadron therapy as an alternative to conventional radiation has led to significant improvements and refinements in conventional treatment techniques. This paper presents the rationale for radiation therapy, describes the accelerators used in conventional and hadron therapy, and outlines the issues that must still be resolved in the emerging field of hadron therapy.

Lennox, Arlene J.

2000-05-30T23:59:59.000Z

159

Fertility, pregnancy, and breastfeeding among younger breast cancer survivors  

E-Print Network (OSTI)

the California Breast Cancer Research Program, who awardedthe California Breast Cancer Research Program, dissertationquality of life. Breast cancer Research and Treatment. 1996;

Gorman, Jessica Lynn Rickard

2009-01-01T23:59:59.000Z

160

Physics and Cancer Student Homepage  

NLE Websites -- All DOE Office Websites (Extended Search)

tests. He had an MRI that showed a growth in the area of swelling around his salivary gland and, after a biopsy, was diagnosed with salivary gland cancer and has been recommended...

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Steps to Preventing Colon Cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

watch out for belly fat. One of the key findings from the CUP report is that excess body fat is linked to increased risk of colorectal cancer. The report also concludes that...

162

EPS Global International Cancer Conference  

NLE Websites -- All DOE Office Websites (Extended Search)

Sept.10-12th, 2010 Suzhou, China Welcome Message Dear Colleagues and Friends, It is my pleasure to announce that EPS Global International Cancer Conference will be held on...

163

Identifying and Understanding the Functional Significance of Cancer Stem Cells in Prostate and Pancreatic Cancer Initiation and Chemoresistance  

E-Print Network (OSTI)

prostate tumorigenesis. Cancer Research, 71: 3459-3470. Kongprogenitor cells. Cancer Research, 72: 1878-89. Murtaughin human brain tumors. Cancer Research, 63: 5821-5828. Steer

Hindoyan, Antreas Agop

2013-01-01T23:59:59.000Z

164

Study of familial breast cancer: identifying additional breast cancer susceptibility loci;.  

E-Print Network (OSTI)

??Breast cancer is a serious public health concern and despite intensive research, the etiology of breast cancer is poorly understood. Known risk factors explain only… (more)

Allen-Brady, Kristina Lisa

2006-01-01T23:59:59.000Z

165

Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer  

E-Print Network (OSTI)

11.  Katoh M.  Cancer genomics and genetics of FGFR2 [Chapter 27  Breast Cancer Genomics  Paul T.  Spellman, 

Spellman, Paul T.

2011-01-01T23:59:59.000Z

166

A RE-LOOK AT THE US NRC SAFETY GOALS  

SciTech Connect

Since they were adopted in 1986, the US NRC’s Safety Goals have played a valuable role as a de facto risk acceptance criterion against which the predicted performance of a commercial nuclear power reactor can be evaluated and assessed. The current safety goals are cast in terms of risk metrics called quantitative health objectives (QHOs), limiting numerical values of the risks of the early and latent health effects of accidental releases of radioactivity to the offsite population. However, while demonstrating compliance with current safety goals has been an important step in assessing the acceptance of the risk posed by LWRs, new or somewhat different goals may be needed that go beyond the current early fatality and latent cancer fatality QHOs in assessing reactor risk. Natural phenomena such as hurricanes seem to be suitable candidates for establishing a background rate to derive a risk goal as their order of magnitude cost of damages is similar to those estimated in severe accident Level 3 PRAs done for nuclear power plants. This paper obtains a risk goal that could have a wider applicability, compared to the current QHOs, as a technology-neutral goal applicable to future reactors and multi-unit sites.

mubayi v.

2013-09-22T23:59:59.000Z

167

Microchip Technology for High-Throughput Cancer Pathology  

E-Print Network (OSTI)

Sequencing in Cancer Research . . . . 80 Appendix A: High-the Warburg Effect. Cancer Research, 2006. 66(18): p. 8927-Breast Cancer Risk. Cancer Research, 2007. 67(10): p. 4687-

Duberow, Jr, David Paul

2009-01-01T23:59:59.000Z

168

Analysis of Senate Bill 1245: Cervical Cancer Screening Test  

E-Print Network (OSTI)

cervical cancer mortality by race/ethnicity Other researchCancer: Recommendations and Rationale. Rockville, MD: Agency for Healthcare Research

California Health Benefits Review Program (CHBRP)

2006-01-01T23:59:59.000Z

169

Genetics and molecular biology of breast cancer  

SciTech Connect

This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

1992-12-31T23:59:59.000Z

170

Targeting cancer metabolism: a therapeutic window opens  

E-Print Network (OSTI)

Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

Vander Heiden, Matthew G.

171

Benedikt Lowe Fatal Heyting Algebras and  

E-Print Network (OSTI)

by Leo Esakia in Tbilisi. When I was visiting Tbilisi in late May 2007, Leo's group asked me to give two discussion when I returned to Tbilisi later that year (October 2007) and Leo informed me then that our "joint

Amsterdam, University of

172

Paper Electrical Fatalities in Northern Ireland  

E-Print Network (OSTI)

A review of autopsy reports in cases of electrocution in Northern Ireland revealed that there were 50 accidental electrocutions and 9 suicidal electrocutions over a 22 year period (1982 – 2003). No cases of homicidal electrocution were detected in this jurisdiction. Analysis of the cohort of accidental electrocutions showed that there was a clear skew towards young and middle-aged male adults with deaths occurring more frequently in the summer months. Almost 60 % of individuals were engaged in occupational tasks when they were accidentally electrocuted. High and low voltagerelated deaths occurred with similar frequency and electrical appliances were found to be responsible for approximately one third of accidental electrocutions. The potential hazards of electricity must continue to be stressed in public safety campaigns if these relatively uncommon but tragic deaths are to be prevented.

James Lucas

2008-01-01T23:59:59.000Z

173

Final November 2011 Accident Investigation Report - Fatality...  

NLE Websites -- All DOE Office Websites (Extended Search)

P2-B) ChangesDeparture from Routine, P2-D) Work-AroundOut-of-Service Instrumentation, P2-J) Excessive Group CohesivenessPeer Pressure, P3-A) Unfamiliarity...

174

Differential expression of anterior gradient gene AGR2 in prostate cancer  

E-Print Network (OSTI)

circulating tumor cells. Cancer research 2005, 48. Kovalev2 in prostate cancer. Cancer research 2010, 19. Zhang Y,cellular transformation. Cancer research 2008, 68(2):492-

2010-01-01T23:59:59.000Z

175

Cell and nanomaterial-based approaches for diagnosis and chemotherapy of metastatic cancer cells  

E-Print Network (OSTI)

Metastasis is a multistep process during which tumor cells separate from a primary tumor, penetrate the bloodstream, evade host defenses, and colonize distant organs. This final and fatal step in tumor development is the ...

Kohli, Aditya (Aditya Gobind)

2010-01-01T23:59:59.000Z

176

Predictive and therapeutic markers in ovarian cancer  

DOE Patents (OSTI)

Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; Fridlyand, Jane; Mills, Gordon B.

2013-03-26T23:59:59.000Z

177

Chest Reirradiation With External Beam Radiotherapy for Locally Recurrent Non-Small-Cell Lung Cancer: A Review  

Science Conference Proceedings (OSTI)

Lung cancer remains one of the most prevalent and deadliest malignancies worldwide. For 2008, the International Agency for the Research of Cancer (IARC) estimated 1.6 million new cancer cases of lung cancer (1.095 million in men and 0.514 million in women), with an associated 1.38 million deaths (0.95 million in men and 0.43 million in women). In the United States, lung cancer remained the number one cancer killer for both sexes in 2009, with 219,440 new cases diagnosed overall and an estimated 159,390 deaths. Recent biological and technological advances in lung cancer management notwithstanding, disease recurrence is still the dominant cause of death after initial treatment of lung cancer. This is irrespective of histology (NSCLC vs. small cell cancer), stage (early vs. locally advanced vs. metastatic), or initial treatment (surgery, RT, chemotherapy [CHT] or combinations thereof). Time to recurrence of lung cancer is not predictable, with some failures appearing early and others manifesting years later. Patterns of failure are also not easily anticipated as local (e.g., lung parenchyma, bronchial stump, or chest wall), regional (e.g., mediastinal lymph nodes), or distant (e.g., brain, liver, or bone) recurrences can appear alone or in combination. Whatever the presentation, recurrent lung cancer has historically been judged almost universally fatal as only rarely did efforts at treatment lead to control, let alone cure. More importantly, recurrence is often associated with significant distress requiring substantial supportive treatment. Recurrence leads ultimately to a significant decrease in patient quality of life, making further interventions even more limited. Because of the bleak outcome associated with recurrence, palliative retreatment has nonetheless often been attempted precisely as a means of preventing this decline in quality of life and/or reversing symptoms. However, complicating these attempts at retreatment has been the forms of initial therapy used to manage the lung cancer, the site of recurrence, and the performance of the patient at relapse. All of these have been relevant to the issue of whether the modality used initially for primary treatment could be both safe and effective in the setting of retreatment. That said, some reports in the surgical literature have suggested, for example, that re-resection in the case of local relapses in selected patients who had previous surgery for stage I lung cancer is feasible and effective and could predict for survival compared to providing the patients with supportive care alone. A particular challenge has been the question of the role and safety of thoracic reirradiation for local recurrences in those patients where RT was used as part of their initial management strategy. Thus, it has been generally assumed that once definitive EBRT has been administered further RT cannot be given because it would likely exceed normal tissue tolerances (6), or, if done, thoracic reirradiation could only be a palliative measure, as the expectation was that patients would not survive to experience potential late effects. A 2007 retrospective study by Estall et al. (4) is instructive in regard to rates of chest reirradiation. Of 527 lung cancer patients treated between 1993 and 1996, the authors reported that 279 (53%) patients were treated at least once with RT, with initial treatment being palliative for 79% of patients, definitive for 14% of patients, and adjuvant for 7% of patients. Of these 279 initial cases, 73 (27%) patients subsequently received a second course of RT, 19 (7%) patients had a third RT course, and 6 (2%) patients received a fourth course. Contemporary technological advances in the diagnosis and staging of lung cancer as well as in the delivery of EBRT, along with the increasing primary role of RT in lung cancer care, now raise the question as to the appropriateness of a palliative-only model for dealing with locally recurrent lung cancer. However, in order to appropriately characterize the historic practice relevant to thoracic reirradiation of recurrent l

Jeremic, Branislav, E-mail: nebareje@gmail.com [Institute of Pulmonary Diseases, Sremska Kamenica (Serbia); Videtic, Gregory M.M. [Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH (United States)

2011-07-15T23:59:59.000Z

178

Cancer in atomic bomb survivors  

SciTech Connect

Radiation carcinogenesis was first noted in studies of individuals with occupational or therapeutic exposure to radiation. Data from long-term follow-up studies of atomic bomb survivors in Hiroshima and Nagasaki have greatly enhanced our knowledge of radiation carcinogenesis. This book presents current results obtained from epidemiological studies and pathological studies on cancer among atomic bomb survivors. It includes a description of the dosimetry system which is currently being revised. Although many of the details about radiation carcinogenesis remain unknown or uncertain, it is clear that the incidence of radiation-induced cancer among atomic bomb survivors continues unabated 40 years after exposure. Recent increases in occupational and environmental exposure to radiation together with the need for a thorough review of radiation protection standards have led to increased recognition of the importance of research on radiation carcinogenesis and risk assessment.

Shigematsu, I.; Kagan, A.

1986-01-01T23:59:59.000Z

179

Air pollution and lung cancer  

SciTech Connect

Epidemiological evidence proves conclusively that lung cancer correlates with air pollution. However, data on lung cancer death rates and smoking show that mankind accepts the risk of long-term and low-level exposure to carcinogens. As a rule, immediate benefits are sought and remote hazards ignored. Fear of atmospheric contamination by radioactive fallout seems to be the main factor for awareness of air pollution. Experimental works help us to understand physics of particle deposition in the lungs (inertial impactation, sedimentation, Brownian movement), shed light on carcinogenesis (eg, bay region theory in case of polycyclic aromatic hydrocarbons and surface charge changes regarding asbestos), show that atmospheric particulates accepted as harmless may act as co-carcinogens (eg, iron and benzo(a)pyrene) and stress the importance of in vitro research (bacterial mutation tests, organ cultures, sister chromatid exchange system) to screen pollutants for their malignant potential and study their pathogenesis.

Boehm, G.M.

1982-01-01T23:59:59.000Z

180

Latent Print AFIS Interoperability Working Group  

Science Conference Proceedings (OSTI)

... Future State of Interoperability (.jpg) • Enter Once, Search ... between examiner time and search accuracy ... DRAFT Glossary of AFIS Terms (PDF) • NEW ...

2013-08-07T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Latent Semantic Indexing with Selective Query Expansion  

Science Conference Proceedings (OSTI)

... Similarly, on topic 402 (not shown), only teams “ot” and “mlb” outperformed the URS system on the initial run with respect to Page 8. estimated F1. ...

2012-02-03T23:59:59.000Z

182

Latent Semantic Indexing (LSI): TREC-3 Report  

Science Conference Proceedings (OSTI)

... Finally,several are about counter intelligence and government security breaches, again not aimed at a specificcompany. ...

1997-09-23T23:59:59.000Z

183

Latent Print Examiner Personnel Selection Test Samples  

Science Conference Proceedings (OSTI)

... examination. The full test and more information is available through Cognitive Profile Testing. Which line matches the line above? ...

2013-04-11T23:59:59.000Z

184

Latent social structure in open source projects  

Science Conference Proceedings (OSTI)

Commercial software project managers design project organizational structure carefully, mindful of available skills, division of labour, geographical boundaries, etc. These organizational "cathedrals" are to be contrasted with the "bazaar-like" nature ... Keywords: collaboration, open source software, social networks

Christian Bird; David Pattison; Raissa D'Souza; Vladimir Filkov; Premkumar Devanbu

2008-11-01T23:59:59.000Z

185

Latent semantic description of iconic scenes  

Science Conference Proceedings (OSTI)

It is proposed an approach for the automatic description of scenes using a LSA–like technique. The described scenes are composed by a set of elements that can be geometric forms or iconic representation of objects. Every icon is characterized by ...

Filippo Vella; Giovanni Pilato; Giorgio Vassallo; Salvatore Gaglio

2005-10-01T23:59:59.000Z

186

Available Technologies: High Selectivity Peptides for Cancer ...  

Biofuels; Biotechnology & Medicine. Diagnostics and Therapeutics; Medical Devices; ... Rac1b: A Highly Selective Marker and Target for Cancer, IB-2167 ;

187

Laser research shows promise for cancer treatment  

NLE Websites -- All DOE Office Websites (Extended Search)

treatment Laser research shows promise for cancer treatment Scientists have observed for the first time how a laser penetrates dense, electron-rich plasma to generate ions. August...

188

HIV/Cancer DB Match Document  

NLE Websites -- All DOE Office Websites (Extended Search)

Los Angeles Massachusetts New York New Jersey San Diego San Francisco Seattle METHODS Matching The Cancer and HIVAIDS records were linked using the commercially...

189

BMC Cancer BioMed Central  

E-Print Network (OSTI)

Research article Genistein inhibits radiation-induced activation of NF-?B in prostate cancer cells promoting apoptosis and G2 /M cell cycle arrest

Julian J Raffoul; Yu Wang; Omer Kucuk; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman

2006-01-01T23:59:59.000Z

190

Improving Screening Strategies for Prostate Cancer.  

E-Print Network (OSTI)

??Th is thesis describes research on screening for prostate cancer. To improve understanding of the thesis, some background information will be provided in this introduction.… (more)

Wolters, T.

2010-01-01T23:59:59.000Z

191

Aligned Nanofiber Multiwell Plates for Cancer Research  

Science Conference Proceedings (OSTI)

Presentation Title, Aligned Nanofiber Multiwell Plates for Cancer Research. Author(s), John Lannutti, Jed Johnson. On-Site Speaker (Planned), John Lannutti

192

Boron Nanotechnology-driven Cancer Therapy  

Science Conference Proceedings (OSTI)

Presentation Title, Boron Nanotechnology-driven Cancer Therapy ... Current research focuses on both the design and synthesis of high boron containing ...

193

Molecular Epidemiology of Human Cancer Risk  

Science Conference Proceedings (OSTI)

Epidemiology has identified several etiological factors in lung cancer, of which the most ... Finally, most molecular epidemiology studies include genetic research.

194

Molecular Cancer BioMed Central  

E-Print Network (OSTI)

A doxycycline-inducible urokinase receptor (uPAR) upregulates uPAR activities including resistance to anoikis in human prostate cancer cell lines

Mohammad Hasanuzzaman; Robert Kutner; Siamak Agha-mohammadi; Jakob Reiser; Inder Sehgal

2007-01-01T23:59:59.000Z

195

Biocompatible Nanoparticle Materials in Cancer Research  

Science Conference Proceedings (OSTI)

The challenges and future perspectives of nanomedicine in cancer research will .... Self-Adaptive, Ultra-Compliant Shape Memory Alloys for Medical Implant ...

196

BMC Cancer BioMed Central  

E-Print Network (OSTI)

Research article Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis

Xiangjun Zhai; Jun Gao; Zhibin Hu; Jinhai Tang; Jianwei Qin; Shui Wang; Xuechen Wang; Guangfu Jin; Jiyong Liu; Wenshen Chen; Feng Chen; Xinru Wang; Qingyi Wei; Hongbing Shen; Qingyi Wei; Hongbing Shen

2006-01-01T23:59:59.000Z

197

Nanomaterials for the detection of cancer-associated biomarkers  

E-Print Network (OSTI)

Prostate cancer persists as a major public health issue in the United States and remains the second leading cause of cancer death in men. Early detection and disease monitoring in prostate cancer can significantly improve ...

Mu, Chunyao Jenny

2010-01-01T23:59:59.000Z

198

Perspectives on the mesenchymal origin of metastatic cancer  

E-Print Network (OSTI)

microenvironments. Cancer Research, 39. Pollard, J. W. (host × tumor hybrids. Cancer Research, 60(9), 2512–2519. 98.program. Clinical Cancer Research, 14(12), 3643–3645. 17.

Huysentruyt, Leanne C.; Seyfried, Thomas N.

2010-01-01T23:59:59.000Z

199

An MRI compatible manipulator for prostate cancer detection and treatment  

E-Print Network (OSTI)

Prostate cancer is the most frequently diagnosed cancer in men and the second most common cause of cancer related death in men. Prostate specific antigen (PSA) blood tests and digital rectal exams (DRE) are preliminary ...

DeVita, Lauren M

2007-01-01T23:59:59.000Z

200

ch_5  

NLE Websites -- All DOE Office Websites (Extended Search)

HLW & FD EIS HLW & FD EIS 5-73 DOE/EIS-0287 tion dose to the nonin- volved worker and maximally exposed offsite individual and the collective dose to the population residing within 50 miles of INTEC. The radiation dose values for the var- ious alternatives were then multiplied by the dose-to-risk conversion factors, which are based on the 1993 Limitations of Exposure to Ionizing Radiation (NCRP 1993). DOE has adopted these risk fac- tors of 0.0005 and 0.0004 latent cancer fatality (LCF) for each person-rem of radiation exposure to the general public and worker popu- lation, respectively, for doses less than 20 rem. The factor for the population is slightly higher due to the presence of infants and children who are more sensitive to radiation than the adult worker population. DOE used radiation dose information provided

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

ch_4  

NLE Websites -- All DOE Office Websites (Extended Search)

71 71 DOE/EIS-0287 Idaho HLW & FD EIS university research programs and private con- tractors. Ongoing studies by the Centers for Disease Control and Prevention, an agency of the U.S. Department of Health and Human Services, also carefully tracks possible health effects from past activities at INEEL. 4.11.1.1 Radiological Health Risk Very low doses of radiation are not known to cause health effects in humans; however, extrapolation of the dose-response relationship from high doses indicates that statistical effects might be observed in large populations. The doses reported in this EIS from INEEL opera- tions are in this very low category. This EIS reports two values: col- lective dose (in person- rem) and the hypothetical number of latent cancer fatalities. For effects on

202

Isotope production facility produces cancer-fighting actinium  

NLE Websites -- All DOE Office Websites (Extended Search)

Cancer therapy gets a boost from new isotope Isotope production facility produces cancer-fighting actinium A new medical isotope project shows promise for rapidly producing major...

203

EA-0965: Cancer Research Center Indiana University School of...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

5: Cancer Research Center Indiana University School of Medicine, Argonne, Illinois EA-0965: Cancer Research Center Indiana University School of Medicine, Argonne, Illinois SUMMARY...

204

Endoscopic Electron-Beam Cancer Therapy | Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Endoscopic Electron-Beam Cancer Therapy Technology available for licensing: A successful and cost-effective means of treating cancer in previously inoperable or radiation-sensitive...

205

Development of Biomarker-based Systems for Cancer ...  

Science Conference Proceedings (OSTI)

... in the US. The cancer community has set a goal to eliminate cancer-related suffering and death by 2015. To achieve this ...

2013-07-23T23:59:59.000Z

206

FAQ 37-What are the potential health risks from transportation of depleted  

NLE Websites -- All DOE Office Websites (Extended Search)

depleted uranium metal or oxide? depleted uranium metal or oxide? What are the potential health risks from transportation of depleted uranium metal or oxide? In the PEIS, risks associated with transportation of depleted uranium oxide and metal were estimated for transport by either rail or truck. Normal transport of oxide or metal would result in low-level external exposure to radiation for persons in the vicinity of a shipment. Based on estimates in the PEIS, the levels of exposure would result in negligible increased cancer risks. Risks from material released in an accident were also estimated. For a hypothetical railcar accident involving powder U3O8 that was assumed to occur in a highly-populated urban area under stable (nighttime) weather conditions, it was estimated that up to 20 people might experience irreversible adverse effects from chemical toxicity, with no fatalities expected. Approximately 2 potential latent cancer fatalities from radiological hazards are estimated for an accident under the same conditions. The probability of such an accident occurring is very low. The consequences from a truck accident would be lower, because trucks have a smaller shipment capacity. The consequences of transportation accidents involving depleted uranium metal would be much smaller than those involving uranium oxide because uranium metal would be in the form of solid blocks and would not be easily dispersed in an accident.

207

ORIGINAL RESEARCH Health Behaviors and Quality of Life of Cancer Survivors in Massachusetts, 2006: Data Use for Comprehensive Cancer Control  

E-Print Network (OSTI)

Pierre S. Health behaviors and quality of life of cancer survivors in Massachusetts, 2006: data use for comprehensive cancer control. Prev Chronic Dis 2010;7(1).

Temeika L. Fairley; Phd Helen Hawk; Phd Snaltze Pierre; Peer Reviewed

2010-01-01T23:59:59.000Z

208

A Geographic Information System (GIS) Analysis of Cancer Clinical Trial Locations in the State of Georgia by Major Cancer Type.  

E-Print Network (OSTI)

??Improving cancer care through clinical research is a major public health issue. However, in Georgia, the exact number of cancer clinical trials is unknown, indicating… (more)

Parker, Shaunta Shanell

2008-01-01T23:59:59.000Z

209

Restoration of normal phenotype in cancer cells  

DOE Patents (OSTI)

A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

1998-01-01T23:59:59.000Z

210

Restoration of normal phenotype in cancer cells  

DOE Patents (OSTI)

A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying {beta}{sub 1} integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive. 14 figs.

Bissell, M.J.; Weaver, V.M.

1998-12-08T23:59:59.000Z

211

Prediction of Breast Cancer Using Artificial Neural Networks  

Science Conference Proceedings (OSTI)

In this study, an artificial neural network (ANN) was developed to determine whether patients have breast cancer or not. Whether patients have cancer or not and if they have its type can be determined by using ANN and BI-RADS evaluation and based on ... Keywords: Artificial neural network, BI-RADS, Breast cancer, Breast cancer prediction

Ismail Saritas

2012-10-01T23:59:59.000Z

212

Manipulating electron beam cancer therapy so it can be used treat internal cancers and tumors has the potential to  

E-Print Network (OSTI)

exposure provides several new cancer therapies or treatments in previously inoperable or radiationManipulating electron beam cancer therapy so it can be used treat internal cancers and tumors has-effective means of treating cancer in previously inoperable or radiation-sensitive areas of the body. Technology

Kemner, Ken

213

Cancer incidence in atomic bomb survivors. Part IV: Comparison of cancer incidence and mortality  

SciTech Connect

This report compares cancer incidence and mortality among atomic bomb survivors in the Radiation Effects Research Foundation Life Span Study (LSS) cohort. Because the incidence data are derived from the Hiroshima and Nagasaki tumor registries, case ascertainment is limited to the time (1958-1987) and geographic restrictions (Hiroshima and Nagasaki) of the registries, whereas mortality data are available from 1950-1987 anywhere in Japan. With these conditions, there were 9,014 first primary incident cancer cases identified among LSS cohort members compared with 7,308 deaths for which cancer was listed as the underlying cause of death on death certificates. When deaths were limited to those occurring between 1958-1987 in Hiroshima or Nagasaki, there were 3,155 more incident cancer cases overall, and 1,262 more cancers of the digestive system. For cancers of the oral cavity and pharynx, skin, breast, female and male genital organs, urinary system and thyroid, the incidence series was at least twice as large as the comparable mortality series. Although the incidence and mortality data are dissimilar in many ways, the overall conclusions regarding which solid cancers provide evidence of a significant dose response generally confirm the mortality findings. When either incidence or mortality data are evaluated, significant excess risks are observed for all solid cancers, stomach, colon, liver (when it is defined as primary liver cancer or liver cancer not otherwise specified on the death certificate), lung, breast, ovary and urinary bladder. No significant radiation effect is seen for cancers of the pharynx, rectum, gallbladder, pancreas, nose, larynx, uterus, prostate or kidney in either series. There is evidence of a significant excess of nonmelanoma skin cancer in the incidence data, but not in the mortality series. 19 refs., 2 figs., 10 tabs.

Ron, E. (Radiation Effects Research Foundation, Hiroshima (Japan) National Cancer Institute, Bethesda, MD (United States)); Preston, D.L.; Mabuchi, Kiyohiko (Radiation Effects Research Foundation, Hiroshima (Japan)); Thompson, D.E. (Radiation Effects Research Foundation, Hiroshima (Japan) George Washington Univ., Rockville, MD (United States) Radiation Effects Research Foundation, Nagasaki (Japan)); Soda, Midori (Radiation Effects Research Foundation, Nagasaki (Japan))

1994-02-01T23:59:59.000Z

214

Coping with Mom's breast cancer: impact of parental cancer on African-American adolescents.  

E-Print Network (OSTI)

??Parental breast cancer is an illness that affects the patient as well as the entire family. A review of literature shows that very limited research… (more)

Dockery, Kimberley D.

2008-01-01T23:59:59.000Z

215

Aging Impacts Transcriptome but not Genome of Hormone-dependent Breast Cancers  

E-Print Network (OSTI)

biological basis linking aging with sporadic breast cancerTranslational Research at the Aging and Cancer Interface.Changes Associated with Aging. Cancer Res 2004, 64:8550-

2007-01-01T23:59:59.000Z

216

Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals  

E-Print Network (OSTI)

8, 2006 Technology in Cancer Research & Treatment, Volume 5,Technology in Cancer Research & Treatment, Volume 5, Number1161- Technology in Cancer Research & Treatment, Volume 5,

Gulsen, Gultekin; Birgul, Ozlem; Unlu, Mehmet Burcin; Shafiiha, Roshanak; Nalcioglu, Orhan

2006-01-01T23:59:59.000Z

217

Economic Impact of the California Cancer Research Act Job Creation and Economic Activity  

E-Print Network (OSTI)

of the California Cancer Research Act | 3 Several healthinitiative, the California Cancer Research Act, on the Juneeducation and breast cancer research). This analysis uses

Glantz, Stanton A.

2012-01-01T23:59:59.000Z

218

Anti-cancer actions in commonly used drugs: epidemiology led by laboratory science.  

E-Print Network (OSTI)

??Despite considerable research on cancer treatments and preventatives, poor outcomes in cancer patients are common. The vital search for effective cancer drugs often begins in… (more)

Walker, Alex J.

2011-01-01T23:59:59.000Z

219

Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy  

E-Print Network (OSTI)

of Experimental & Clinical Cancer Research 2013 32:57.Stem Cell & Translational Cancer Research Center, Chang GungExperimental & Clinical Cancer Research 2013, 32:57 http://

Williams, Richard T; Yu, Alice L; Diccianni, Mitchell B; Theodorakis, Emmanuel A; Batova, Ayse

2013-01-01T23:59:59.000Z

220

Defining the critical hurdles in cancer immunotherapy  

E-Print Network (OSTI)

representing Europe, Japan, China and North America to discuss collaborations to improve development, reagents, drugs and clinical protocols with potential to significantly improve cancer outcomes. Nowhere, China and North

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Engineering persistent interleukin-2 for cancer immunotherapy  

E-Print Network (OSTI)

Mobilizing the immune system to recognize and destroy tumor cells is a promising strategy for treating cancer. In contrast to standard therapeutic approaches such as surgery, radiation, and chemotherapy, immunotherapy ...

Gai, Shuning

2012-01-01T23:59:59.000Z

222

Nanoparticles in cancer imaging and therapy  

Science Conference Proceedings (OSTI)

Nanoparticle contrast agents offer the potential to significantly improve existing methods of cancer diagnosis and treatment. Advantages include biocompatibility, selective accumulation in tumor cells, and reduced toxicity. Considerable research is underway ...

Leon Smith; Zdenka Kuncic; Kostya Ostrikov; Shailesh Kumar

2012-01-01T23:59:59.000Z

223

Stromal Endothelial Cells Directly Influence Cancer Progression  

E-Print Network (OSTI)

Cancer growth and metastasis are regulated in part by stromal cells such as fibroblasts and immune cells within the tumor microenvironment. Endothelial cells (ECs) are also ubiquitous within tumors because tumors are ...

Franses, Joseph Wang

224

Risk analysis of shipping plutonium pits and mixed oxide fuel  

E-Print Network (OSTI)

With the end of the cold war, there no longer seems to be a credible threat of war between nuclear superpowers, with its possible consequence of billions of fatalities. However, the residue of the cold war, most notably the now excess weapons plutonium, has been identified as the source of a number of potential catastrophes. For example, just a single crude nuclear weapon in the hands of a terrorist organization or rogue state and detonated in even a medium-sized city could lead to hundreds of thousands of deaths. For this reason, the ultimate disposition of this excess plutonium has been identified as a national priority. The process of carrying out this disposition itself carries some risks, and even though any conceivable consequences clearly will be much smaller in magnitude than those cited above, U.S. federal law (the National Environmental Protection Act) mandates that such risks must be analyzed. The ability to carry out one type of such an analysis is demonstrated in this thesis. Specifically, one possible option that has been identified for disposition of excess U.S. weapons plutonium is the transformation into mixed oxide (MOX) fuel, that then would be used as fuel in a commercial nuclear power plant. Any such process will involve the transportation of the MOX fuel from the MOX fuel fabrication facility to the nuclear power plant, and possibly transportation of the plutonium from a storage site to the fuel fabrication facility. This thesis is intended to demonstrate the capability to analyze the risks associated with such transportation campaigns. The primary tool used for these analyses was RADTRAN, a code developed by Sandia National Laboratories for evaluating risk associated with the transportation of radioactive materials. Two sample scenarios were explored relative to the transformation of plutonium pits to MOX fuel. First, the pits would be converted to MOX fuel at a fuel fabrication facility located either at the Pantex Plant or the Savannah River Site (SRS), and then the MOX fuel would be ultimately shipped to a final destination of a commercial power plant, the Palo Verde Generating Station in Arizona. For the scenario of placing the MOX fuel fabrication facility at SRS, pits would need to be shipped from Pantex to SRS and then the MOX fuel would be shipped to Palo Verde. The total number of expected fatalities over a 25 year campaign duration for this scenario would be 1.06, with 0. 1 73 fatalities resulting from latent cancer fatalities due to radiation exposure and 0.89 resulting from traffic accidents. For the placement of the MOX fuel fabrication facility at Pantex, only the MOX fuel would need to be transported from one facility to another, in this case from Pantex to Palo Verde. The total fatalities for this scenario over 25 years would be 0.413, resulting from 5.29 x 10-2 latent cancer fatalities and 0.36 traffic accident fatalities. The maximum exposed individual along any of the three routes would receive 1.0 X 10-5 rem per year or 0.25 mrem over 25 years.

Caldwell, Amy Baker

1997-01-01T23:59:59.000Z

225

Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer  

SciTech Connect

Breast cancer is predominantly a disease of the genome with cancers arising and progressing through accumulation of aberrations that alter the genome - by changing DNA sequence, copy number, and structure in ways that that contribute to diverse aspects of cancer pathophysiology. Classic examples of genomic events that contribute to breast cancer pathophysiology include inherited mutations in BRCA1, BRCA2, TP53, and CHK2 that contribute to the initiation of breast cancer, amplification of ERBB2 (formerly HER2) and mutations of elements of the PI3-kinase pathway that activate aspects of epidermal growth factor receptor (EGFR) signaling and deletion of CDKN2A/B that contributes to cell cycle deregulation and genome instability. It is now apparent that accumulation of these aberrations is a time-dependent process that accelerates with age. Although American women living to an age of 85 have a 1 in 8 chance of developing breast cancer, the incidence of cancer in women younger than 30 years is uncommon. This is consistent with a multistep cancer progression model whereby mutation and selection drive the tumor's development, analogous to traditional Darwinian evolution. In the case of cancer, the driving events are changes in sequence, copy number, and structure of DNA and alterations in chromatin structure or other epigenetic marks. Our understanding of the genetic, genomic, and epigenomic events that influence the development and progression of breast cancer is increasing at a remarkable rate through application of powerful analysis tools that enable genome-wide analysis of DNA sequence and structure, copy number, allelic loss, and epigenomic modification. Application of these techniques to elucidation of the nature and timing of these events is enriching our understanding of mechanisms that increase breast cancer susceptibility, enable tumor initiation and progression to metastatic disease, and determine therapeutic response or resistance. These studies also reveal the molecular differences between cancer and normal that may be exploited to therapeutic benefit or that provide targets for molecular assays that may enable early cancer detection, and predict individual disease progression or response to treatment. This chapter reviews current and future directions in genome analysis and summarizes studies that provide insights into breast cancer pathophysiology or that suggest strategies to improve breast cancer management.

Spellman, Paul T.; Heiser, Laura; Gray, Joe W.

2009-06-18T23:59:59.000Z

226

Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones  

E-Print Network (OSTI)

malignant breast. Cancer Research 59 1757–1763s; discussionfactor withdrawal. Cancer Research 56 2039–2044. Bunone G,cancer cells. Breast Cancer Research and Treatment 31 227–

Hansen, R K

2010-01-01T23:59:59.000Z

227

Polymorphisms in the stem cell pathway and esophageal cancer in a Chinese population  

E-Print Network (OSTI)

Mapping 10K Array. Cancer research, 2005. 65(7): p. 2542-American Association for Cancer Research, 1997. 8(12): p.Colorectal Cancer. Cancer Research, 2010. 70(16): p. 6629-

Wallar, Gina

2013-01-01T23:59:59.000Z

228

Early dissemination of bevacizumab for advanced colorectal cancer: a prospective cohort study  

E-Print Network (OSTI)

Cancer Institute/Cancer Research Network (grant number U01in the NCI-funded Cancer Research Network, and fifteenOutcomes: The Cancer Care Outcomes Research and Surveillance

2011-01-01T23:59:59.000Z

229

Multi-parametric numerical simulation of age-specific cancer rates in human populations  

E-Print Network (OSTI)

The CancerFit computer program allows cancer researchers to analyze epidemiologic data describing the age-specific risk of cancer in terms of hypotheses about historical environmental risks, the heritability of cancer, the ...

Kogel, John, 1981-

2004-01-01T23:59:59.000Z

230

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Enzyme Structure Provides Insights into Cancer and Aging Print Wednesday, 25 February 2009 00:00 XPD helicase is an enzyme...

231

The Antioxidant Vitamins C & EChapter 4 Vitamin C and Cancer  

Science Conference Proceedings (OSTI)

The Antioxidant Vitamins C & E Chapter 4 Vitamin C and Cancer Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press Downloadable pdf of Chapter 4 Vitamin C and Cancer from ...

232

Impact of deleterious passenger mutations on cancer progression  

E-Print Network (OSTI)

Cancer progression is driven by the accumulation of a small number of genetic alterations. However, these few driver alterations reside in a cancer genome alongside tens of thousands of additional mutations termed passengers. ...

Korolev, Kirill Sergeevich

233

NATIONAL INSTITUTES OF HEALTH | National Cancer Institute LABORATORY OF PATHOLOGY  

E-Print Network (OSTI)

NATIONAL INSTITUTES OF HEALTH | National Cancer Institute LABORATORY OF PATHOLOGY National Cancer Institute (NCI) The Laboratory of Pathology, based in the NCI, provides clinical service in anatomic-scientists DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute, Center

234

Graduate Program in Cancer Cell Biology CELL SHEDDING  

E-Print Network (OSTI)

Graduate Program in Cancer Cell Biology CELL SHEDDING ANOIKIS CELL SHEDDING METASTASIS NORMAL CELLS) To the Cancer Cell Biology Program: As a Graduate Student in the Cancer Cell Biology Program, I acknowledge account of my laboratory work, commit to ethics before science and devote my full and undivided time

Mohaghegh, Shahab

235

Usability of mobile computing technologies to assist cancer patients  

Science Conference Proceedings (OSTI)

Medical researchers are constantly looking for new methods for early detection and treatment of incurable diseases. Cancer can severely hinder the lives of patients if they are not constantly attended to. Cancer patients can be assisted with the aid ... Keywords: MARKS, TinyOS, cancer, chemotherapy, mote, pervasive health care, tmote sky, wellness monitor

Rezwan Islam; Sheikh I. Ahamed; Nilothpal Talukder; Ian Obermiller

2007-11-01T23:59:59.000Z

236

Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies  

Science Conference Proceedings (OSTI)

Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

2012-07-01T23:59:59.000Z

237

Catalyzing social support for breast cancer patients  

Science Conference Proceedings (OSTI)

Social support is a critical, yet underutilized resource when undergoing cancer care. Underutilization occurs in two conditions: (a) when patients fail to seek out information, material assistance, and emotional support from family and friends or (b) ... Keywords: health consumers, participatory design, social network

Meredith M. Skeels; Kenton T. Unruh; Christopher Powell; Wanda Pratt

2010-04-01T23:59:59.000Z

238

Modern breast cancer detection: a technological review  

Science Conference Proceedings (OSTI)

Breast cancer is a serious threat worldwide and is the number two killer of women in the United States. The key to successful management is screening and early detection. What follows is a description of the state of the art in screening and detection ...

Adam B. Nover; Shami Jagtap; Waqas Anjum; Hakki Yegingil; Wan Y. Shih; Wei-Heng Shih; Ari D. Brooks

2009-01-01T23:59:59.000Z

239

Toward Early Diagnosis of Lung Cancer  

Science Conference Proceedings (OSTI)

Our long term research goal is to develop a fully automated, image-based diagnostic system for early diagnosis of pulmonary nodules that may lead to lung cancer. In this paper, we focus on generating new probabilistic models for the estimated growth ...

Ayman El-Baz; Georgy Gimel'Farb; Robert Falk; Mohamed Abou El-Ghar; Sabrina Rainey; David Heredia; Teresa Shaffer

2009-10-01T23:59:59.000Z

240

The use of polarized light for skin cancer detecton  

E-Print Network (OSTI)

Over 50,000 people per year will be diagnosed with skin cancer in one of its various forms, making it the seventh most common form of cancer in the United States. Currently the only method to diagnose suspicious lesions is visual inspection and subsequent biopsy of suspicious lesions. Many cancerous lesions are missed and many benign lesions are biopsied using these techniques. This process is painful and expensive. The proposed research is driven by the need for a non-invasive skin cancer detection system. Presented here is a method for the optical determination of cancerous tissue using polarized light. This thesis describes the development of a polarimetric imaging system including its calibration and testing. In addition, experiments are performed to simulate changes in tissue, such as increased size of scatterers and increased scattering and absorption coefficients that often accompany tissue changes as it becomes cancerous. The effects of these simulated changes are tested on the Polarimetric imaging system in order to quantify changes in the Mueller matrix caused by the perturbations, and ultimately to relate them to observed changes in the Mueller matrices of cancerous and non-cancerous tissue. Finally, the Polarimetric imaging system is used to determine the Mueller matrix of cancerous and non-cancerous tissue to assess the system's capabilities for skin cancer diagnosis.

DeLaughter, Aimee Hill

2002-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

doi:10.5402/2011/617082 Research Article Epithelial Ovarian Cancer and the Occurrence of Skin Cancer in  

E-Print Network (OSTI)

Copyright © 2011 Catharina C. van Niekerk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Patients with epithelial ovarian cancer have a high risk of (non-)melanoma skin cancer. The association between histological variants of primary ovarian cancer and skin cancer is poorly documented. Objectives. To further evaluate the risk of skin cancer based on the histology of the epithelial ovarian cancer. Methods. A cross-sectional study within a large populationbased dataset. Results. Skin cancer was found in 2.7 % (95 % CI: 2.3–3.1) of the 5366 individuals forming our dataset. The odds ratio (OR) for endometrioid cancer in the ovary to skin cancer in the under 50 age group was 8.9 (95 % CI: 3.2–25.0). The OR decreased in older patients to 1.2. Conclusions. Patients with epithelial ovarian malignancies show an increased risk of skin cancer. A significantly increased risk (4.3%) for endometrioid ovarian cancer was found in the group aged under 50. 1.

Isrn Obstetrics; Catharina C. Van Niekerk; Johan Bulten; Andrél. M. Verbeek

2011-01-01T23:59:59.000Z

242

Analyzing Geographic Patterns of Disease Incidence: Rates of Late-Stage Colorectal Cancer in Iowa  

Science Conference Proceedings (OSTI)

This study, using geocodes of the locations of residence of newly diagnosed colorectal cancer patients from the Iowa Cancer Registry, computed continuous spatial patterns of late-stage rates of colorectal cancer in Iowa. Variations in rates in intrahospital ... Keywords: GIS, SEER, colorectal cancer, geocodes, late-stage cancer

Gerard Rushton; Ika Peleg; Aniruddha Banerjee; Geoffrey Smith; Michele West

2004-06-01T23:59:59.000Z

243

Cancer-fighting treatment gets boost from Isotope Production Facility  

NLE Websites -- All DOE Office Websites (Extended Search)

Cancer-fighting treatment gets boost from Isotope Production Cancer-fighting treatment gets boost from Isotope Production Facility Cancer-fighting treatment gets boost from Isotope Production Facility New capability expands existing program, creates treatment product in quantity. April 13, 2012 Medical Isotope Work Moves Cancer Treatment Agent Forward Medical Isotope Work Moves Cancer Treatment Agent Forward - Los Alamos scientist Meiring Nortier holds a thorium foil test target for the proof-of-concept production experiments. Research indicates that it will be possible to match current annual, worldwide production of Ac-225 in just two to five days of operations using the accelerator at Los Alamos and analogous facilities at Brookhaven. Alpha particles are energetic enough to destroy cancer cells but are unlikely to move beyond a tightly controlled target region and destroy

244

Editorial Breast Cancer Research – the first ten years  

E-Print Network (OSTI)

Breast Cancer Research was launched in 1999 with the aim of providing a home for translational research in breast cancer [1]. The field of translational research has advanced considerably over the past ten years, and the journal has evolved over this time to meet the changing needs of the breast cancer research community. As we celebrate Breast Cancer Research’s 10 th birthday, we take this opportunity to reflect on the journal’s growth over the last decade. Breast Cancer Research is committed to open access publication of research articles, and remains the only journal in the breast cancer field dedicated to open access. Open access means research is universally and freely available via the Internet. Authors retain their own copyright, allowing them to grant any third party the right to use, reproduce and disseminate the article. Open access has broad benefits both

Frances Mulvany; Bruce Aj Ponder

2008-01-01T23:59:59.000Z

245

6.21 Improving Neutron Beams for Cancer Treatment  

NLE Websites -- All DOE Office Websites (Extended Search)

the most advanced epithermal neutron source in the world for cancer treatment. Social Impact: Preliminary trials of BNCT therapy supported by the Office of Science have shown...

246

Neutron Imaging Explored as Complementary Technique for Improving Cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

Neutron Imaging Explored as Complementary Technique for Improving Cancer Neutron Imaging Explored as Complementary Technique for Improving Cancer Detection August 05, 2013 Researcher Maria Cekanova analyzes the neutron radiographs of a canine breast tumor (black color in top image of monitor screen) using the software to visualize in color the various intensities of neutron transmissions through the breast tissue. ORNL and University of Tennessee collaboration now analyzing first results from neutron radiographs of cancerous tissue samples Today's range of techniques for detection of breast and other cancers include mammography, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, positron emission tomography (PET), and optical imaging. Each technology has advantages and disadvantages, with limitations either

247

Former Worker Program - Early Lung Cancer Detection Program  

NLE Websites -- All DOE Office Websites (Extended Search)

Former Worker Program (FWP) Former Worker Program (FWP) Home Covered Sites/Populations › Construction Worker Screening Projects › Production Worker Screening Projects › Supplemental Screening Program › Beryllium Vendor Screening Program Upcoming Events Program Implementation Outreach Medical Screening - Conventional Medical Screening - Early Lung Cancer Detection Communicating Results Protecting Participant Information Sharing De-identified Data Chronic Beryllium Disease Awareness Joint Outreach Task Group (JOTG) Worker Testimonials Contact Us FWP Scientific Publications FWP Documents Related Links Office of Health and Safety Home Page HSS Logo Early Lung Cancer Detection Program Former Worker Medical Screening Program (FWP) Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer. Through the FWP, DOE initiated the Early Lung Cancer Detection (ELCD) program using low-dose helical CT scans to detect lung cancers at an earlier, more treatable stage. Lung cancer results in about 160,000 deaths in the U.S. every year. The most common causes of lung cancer are long-term exposures to tobacco smoke and residential radon emissions, but occupational hazards, such as asbestos and ionizing radiation, also cause or contribute to the disease.

248

What Connects Rat Tails to Cancer and Heart Disease?  

NLE Websites -- All DOE Office Websites (Extended Search)

What Connects Rat Tails to Cancer and Heart Disease? Collagen is the main (and most abundant) protein in all mammalian connective tissues, including those of the heart, lungs,...

249

Progress on Production of Alpha-emitting Radioisotopes for Cancer...  

Office of Science (SC) Website

Progress on Production of Alpha-emitting Radioisotopes for Cancer Therapy Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Funding...

250

Molecular cytogenetic characterization of a human thyroid cancer cell line  

E-Print Network (OSTI)

gland during the Chernobyl catastrophe. Environmental Healthradiation as a result of the Chernobyl disaster. Cancer 76,1986 nuclear accident in Chernobyl, Ukraine. In the twelve

2006-01-01T23:59:59.000Z

251

Tumor initiating but differentiated luminal-like breast cancer ...  

... Oslo, Norway; cCancer Stem Cell Innovation Center, Oslo ... the above explanation always must be ... Fold change analysis of the miRNA microarray ...

252

DNA repair: Dynamic defenders against cancer and aging  

E-Print Network (OSTI)

developmental defects; premature aging; brittle hair; scalypredisposition and premature aging. Acknowledgements. Weagainst cancer and aging Jill O. Fuss and Priscilla K.

Fuss, Jill O.; Cooper, Priscilla K.

2006-01-01T23:59:59.000Z

253

Serum 25-hydroxyvitamin D and risk of breast cancer  

E-Print Network (OSTI)

The relationship of solar radiation to cancer mortality ininvolving exposure to solar radiation. Prev Med. 1990;19:and amount of solar radiation in 49 US metropolitan areas

Mohr, Sharif Burgette

2012-01-01T23:59:59.000Z

254

Cancer research at Berkeley Lab: the intersection of science...  

NLE Websites -- All DOE Office Websites (Extended Search)

Climate September Conservation October Geosciences November Chemistry December Health Cancer research at Berkeley Lab: the intersection of science and health Mention the...

255

Translational Research on Esophageal Cancer: From Cell Line to Clinic.  

E-Print Network (OSTI)

??Worldwide esophageal cancer is a signifi cant and an increasing health problem. In 2005, there were 497,700 new cases, and the prevalence is expected to… (more)

Boonstra, J.J.

2011-01-01T23:59:59.000Z

256

Early clinical cancer trials: Proof of concept and beyond.  

E-Print Network (OSTI)

??Over the last few decades clinical cancer research has developed at accelerating speed, resulting in a tremendous increase of knowledge with regard to tumour biology,… (more)

Konings, I.R.H.M.

2011-01-01T23:59:59.000Z

257

Stromal Modulation of Radiation Carcinogenesis in Breast Cancer  

E-Print Network (OSTI)

and age at exposure for all solid cancers as a group and many individual sites as a consequence of the atomic

Nguyen, David Hiendat Hua

2011-01-01T23:59:59.000Z

258

Yeast-based vaccine approaches to cancer immunotherapy  

E-Print Network (OSTI)

Saccharomyces cerevisiae stimulates dendritic cells and represents a promising candidate for cancer immunotherapy development. Effective cross-presentation of antigen delivered to dendritic cells is necessary for successful ...

Howland, Shanshan W

2008-01-01T23:59:59.000Z

259

Improved Treatment of X-ray Resistant & Inoperable Cancers ...  

If the electron beam can be transported to the internal cancer without exposure to tissue, ... This figure shows a comparison of X-ray radiation ...

260

Medical Imaging for Breast Cancer - Reducing the Need for Biopsy  

Jefferson Lab is a Department of Energy national laboratory for nuclear physics research. ... Medical Imaging for Breast Cancer - Reducing the Need for Biopsy

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL...  

Office of Science (SC) Website

Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Spinoff Applications...

262

Proteomic Study of Oral Cancer Stem-Like Cells and Bone Marrow Cell Treatment for Sjögren's Syndrome  

E-Print Network (OSTI)

Carcinoma. Clinical Cancer Research, 2008. 14(13): p. 4085-Cell Lung Cancer. Cancer Research, 2008. 68(15): p. 6065-Inducible Factor-1?. Cancer Research, 2006. 66(7): p. 3688-

Misuno, Kaori

2013-01-01T23:59:59.000Z

263

A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer  

E-Print Network (OSTI)

breast cancer. Breast Cancer Research 2010 12:R85. SubmitYau et al. Breast Cancer Research 2010, 12:R85 http://cited Yau et al. Breast Cancer Research 2010, 12:R85 http://

Yau, Christina; Esserman, Laura; Moore, Dan H; Waldman, Fred; Sninsky, John; Benz, Christopher C

2010-01-01T23:59:59.000Z

264

The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression  

E-Print Network (OSTI)

migration and invasion. Cancer Research 65, 11572- Hiraguri,cancer cell lines. Cancer Research 58, 1972-1977. Irie,of tumor cells. Cancer Research 47, 3239-3245. Ashburner,

2008-01-01T23:59:59.000Z

265

The Role of Non-Mutated Signaling Networks and Inflammatory Cytokines in the Initiation and Progression of Prostate Cancer  

E-Print Network (OSTI)

for the AACR Special Conference in Cancer Research: Advancesin Prostate Cancer Research, Orlando, FL. Smith DA, Zong Y,Cancer Cells. Clinical Cancer Research. 2003;9:370–6. Smith

Smith, Daniel Alan

2013-01-01T23:59:59.000Z

266

WE?A?213AB?01: Second Cancers from Radiation Therapy Procedures  

Science Conference Proceedings (OSTI)

Second Cancers are the most common late effect among long?term cancer survivors. Radiation has been a known risk factor for cancer induction based on atomic bomb survivor follow?up. Over the last few decades

S Kry; R Howell

2012-01-01T23:59:59.000Z

267

Recent breast cancer incidence trends according to hormone therapy use: the California Teachers Study cohort  

E-Print Network (OSTI)

breast cancer incidence trends according to hormone therapyA, Ward E, Thun MJ: Recent trends in breast cancer incidencein France: a paradoxical trend. Bull Cancer 10. Katalinic A,

2010-01-01T23:59:59.000Z

268

Recent breast cancer incidence trends according to hormone therapy use: the California Teachers Study cohort  

E-Print Network (OSTI)

Study cohort. Breast Cancer Research 2010 12:R4. Submit yourMarshall et al. Breast Cancer Research 2010, 12:R4 http://Marshall et al. Breast Cancer Research 2010, 12:R4 http://

2010-01-01T23:59:59.000Z

269

Separation of cancer cells from peripheral blood mononuclear cells using pH control and dielectrophoresis  

E-Print Network (OSTI)

System. Clinical Cancer Research, 2007. 13(3): p.920 – 928.Solid Tumors. Clinical Cancer Research, 1999. 5:p.1950-1960.Diseases. Clinical Cancer research, 2004. 10:p.6897-6904.

Pattanaik, Malisha

2009-01-01T23:59:59.000Z

270

Can A Virus Cause Cancer: A Look Into The History And Significance Of Oncoviruses  

E-Print Network (OSTI)

of Tumor Virology. Cancer Research. 68(19): 7693-7706. deof the role of viruses in cancer, research on the subject2004. Conncecting Viruses to Cancer: How Research Moves from

Rwazavian, Niema

2011-01-01T23:59:59.000Z

271

beta1 Integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib  

E-Print Network (OSTI)

resistant to lapatinib. Breast Cancer Research 2011 13:R84.96. Huang et al. Breast Cancer Research 2011, 13:R84 http://Huang et al. Breast Cancer Research 2011, 13:R84 http://

2011-01-01T23:59:59.000Z

272

Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment  

E-Print Network (OSTI)

radiation treatment. Breast Cancer Research 2010 12:R13.Lagadec et al. Breast Cancer Research 2010, 12:R13 http://Lagadec et al. Breast Cancer Research 2010, 12:R13 http://

2010-01-01T23:59:59.000Z

273

Development of alternating amphiphilic copolymers for targeted delivery applications in cancer  

E-Print Network (OSTI)

According to the American Cancer Society, approximately 1,479,000 new cases of cancer were expected to be diagnosed, while 562,340 Americans were expected to die from cancer in 2009 alone. Even though advances in early ...

Brower, Kevin P. (Kevin Peter)

2011-01-01T23:59:59.000Z

274

A Framework for Developing, Implementing, and Evaluating a Cancer Survivorship Curriculum for Medical Students  

E-Print Network (OSTI)

Effects of a dedicated curriculum. J Cancer Educ. 2007; 224,illness: Competencies for a curriculum for medical students.first year medical school curriculum. J Cancer Educ. 2004;

Uijtdehaage, Sebastian; Hauer, Karen E.; Stuber, Margaret; Rajagopalan, Shobita; Go, Vay L.; Wilkerson, LuAnn

2009-01-01T23:59:59.000Z

275

Cancer Screening in California: Findings from the 2001 California Health Interview Survey  

E-Print Network (OSTI)

American Cancer Society, California Division, and PublicDiabetes in California: CancerScreening in California: Findings from the 2001 California

Ponce, Ninez A.; Babey, Susan H.; Etzioni, David; Spencer, Benjamin A.; Brown, E. Richard R; Chawla, Neetu

2003-01-01T23:59:59.000Z

276

Dworshak-Taft #1 Fatal Fall September 20, 2012  

NLE Websites -- All DOE Office Websites (Extended Search)

... Appendix D-1 Figure 1: Aerial Map of the Access Road to Tower 834 from the Fly Yard ... 3 Figure 2:...

277

-blockers and Cocaine: Fatal Attraction? Cristina Gonzales, PharmD  

E-Print Network (OSTI)

5 Gebruik van ArchiMate bij Dunea 27 5.1 Huidig gebruik 27 5.2 Mogelijk gebruik in de toekomst 27 6 Aanbevelingen voor Dunea 30 8.1 Strategie, strategische doelen en verbeterpunten 30 8.2 Beleidsuitgangspunten 31.5 Metamodel 32 8.6 Ontwikkelingen 32 9 Bronnen 33 #12;3 Samenvatting Dunea gebruikt het Novius model om

Pillow, Jonathan

278

A Climatology of Fatal Convective Wind Events by Storm Type  

Science Conference Proceedings (OSTI)

There are still hundreds of casualties produced by thunderstorm hazards each year in the United States despite the many recent advances in prediction and mitigation of the effects of convective storms. Of the four most common thunderstorm hazards ...

Joseph M. Schoen; Walker S. Ashley

2011-02-01T23:59:59.000Z

279

BIRD FATALITY ASSOCIATIONS AND PREDICTIVE MODELS FOR THE APWRA  

E-Print Network (OSTI)

at those models in our sample in the APWRA Micon 65 Bonus Danwin Flowind Windmatic Enertech KCS-56 KVS-33 Enertech KCS-56 KVS-33 Howden Nordtank W.E.G. 25002000150010005000 N Effort Turbine model Sum proportion Predictor Variable df GOEA RTHA AMKE BUOW BAOW GHOW Turbine model 10 17.98t 20.70* 78.59** 44.59** 7.23 5

280

Projecting Fatalities in Crashes Involving Older Drivers, 2000...  

NLE Websites -- All DOE Office Websites (Extended Search)

ALS Activity Limitation Status AMA American Medical Association AoA Administration on Aging BEA Bureau of Economic Analysis BLS Bureau of Labor Statistics CODES Crash Outcome...

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Fatal Flaw Analysis of Utility-Scale Wind Turbine Generators...  

NLE Websites -- All DOE Office Websites (Extended Search)

Agreement IAG-08-0719 and Task No. WFD3.1001. Technical Report NRELTP-7A30-58768 August 2013 NREL is a national laboratory of the U.S. Department of Energy Office of...

282

Questions and Answers About Female Breast Cancer What is Breast Cancer?  

E-Print Network (OSTI)

the radiation from a mammogram? Should I worry about this? Data from the atomic bomb survivors and other groups. The single most effective way a woman can detect early breast cancer is through routine mammography medical history · Physical exam which includes palpation of the breast and nearby lymph nodes · Imaging

283

Targeting NRF2 signaling for cancer chemoprevention  

SciTech Connect

Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

Kwak, Mi-Kyoung, E-mail: mkwak@ynu.ac.k [College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749 (Korea, Republic of); Kensler, Thomas W. [Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (United States)

2010-04-01T23:59:59.000Z

284

Narrow focus ultra-wideband antenna for breast cancer detection  

Science Conference Proceedings (OSTI)

A narrow focus ultra-wideband dielectric-filled antenna has been designed for the purpose of near-field breast cancer detection without the use of coupling media. Instead of immersing the antenna in a lossy liquid coupling medium, direct matching of ... Keywords: antenna feeds, antennas, breast cancer detection, directional, radar-based imaging, ultra-wide band

Daniel M. Hailu; Safieddin Safavi-Naeini

2009-01-01T23:59:59.000Z

285

Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene  

E-Print Network (OSTI)

. IKK3 acti- vates the nuclear factor-kappaB (NF-kB) path- way in both cell lines and breast cancers. These observations suggest a mechanism for NF-kB activation in breast cancer, implicate the NF-kB pathway

286

Lab Breakthrough: Nanomaterials Discoveries Lead to Possible Cancer  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Lab Breakthrough: Nanomaterials Discoveries Lead to Possible Cancer Lab Breakthrough: Nanomaterials Discoveries Lead to Possible Cancer Treatment Lab Breakthrough: Nanomaterials Discoveries Lead to Possible Cancer Treatment June 4, 2012 - 3:05pm Addthis Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. View the entire Lab Breakthrough playlist. Michael Hess Michael Hess Former Digital Communications Specialist, Office of Public Affairs What is a nano-bio catalyst? A nanoparticle that triggers specific reactions in cells. The particle attaches to unwanted (tumor) cells, and when researchers shine light on them, they kill the cells through oxidation.

287

Commentary Breast cancer and childhood anthropometry: emerging hypotheses?  

E-Print Network (OSTI)

In this issue of Breast Cancer Research, Baer and colleagues report a strong protective effect of childhood and adolescent body fatness on premenopausal breast cancer risk based on a large prospective study. Methodological issues are discussed, as are tentative biological interpretations regarding the findings. In this issue of Breast Cancer Research, Baer and colleagues [1] report a strong protective effect of childhood and adolescent body fatness on premenopausal breast cancer risk. The report is based on the Nurses ’ Health Study II, a prospective cohort study including 116,671 US female nurses, aged 25–42 years at recruitment in 1989, in which 1318 breast cancer cases occurred during 12 years of follow up. There were slightly stronger associations between average childhood and adolescent body fatness and

Cecilia Mk Magnusson; Andrew W Roddam

2005-01-01T23:59:59.000Z

288

A PET/CT directed, 3D ultrasound-guided biopsy system for prostate cancer  

Science Conference Proceedings (OSTI)

Prostate cancer affects 1 in 6 men in the USA. Systematic transrectal ultrasound (TRUS)-guided biopsy is the standard method for a definitive diagnosis of prostate cancer. However, this "blind" biopsy approach can miss at least 20% of prostate cancers. ... Keywords: 3D ultrasound imaging, PET/CT, image segmentation, imageguided biopsy, molecular imaging, nonrigid image registration, prostate cancer, wavelet transform

Baowei Fei; Viraj Master; Peter Nieh; Hamed Akbari; Xiaofeng Yang; Aaron Fenster; David Schuster

2011-09-01T23:59:59.000Z

289

The improvement of breast cancer prognosis accuracy from integrated gene expression and clinical data  

Science Conference Proceedings (OSTI)

Predicting the accurate prognosis of breast cancer from high throughput microarray data is often a challenging task. Although many statistical methods and machine learning techniques were applied to diagnose the prognosis outcome of breast cancer, they ... Keywords: Breast cancer prognosis, Cancer classification, Clinical data, Gene expression, Gene selection, Genetic algorithm, Support vector machine

Austin H. Chen; Chenyin Yang

2012-04-01T23:59:59.000Z

290

PROCEEDINGS Open Access The possible prevention of cancer  

E-Print Network (OSTI)

The prevention of the infectious diseases was accomplished long before there was any understanding of the molecular biology of bacteria and viruses. As for cancer, the sharp drop in frequency of the once-commonest lethal cancer, stomach cancer, was achieved without any contribution from biological research, and the current drop in lung cancer is the end-result of the observation by epidemiologists that most lung cancer is caused by smoking. So the basis for both these triumphs was essentially empirical and owed nothing to biological research. This paper discusses how molecular biology can now offer the possibility of large-scale protection against cancer. Article Research into cancer has in the past been largely managedbydoctorsandtheemphasishastendedtobeon finding new treatments rather than on prevention. But it is quite clear that life expectancy in the industrialised world had almost doubled by the time the first antibiotics were discovered [1], and this must therefore have been achieved by prevention of the major infectious diseases rather than by devising better forms of treatment.

John Cairns

2009-01-01T23:59:59.000Z

291

Review Genomic approaches to research in lung cancer  

E-Print Network (OSTI)

The medical research community is experiencing a marked increase in the amount of information available on genomic sequences and genes expressed by humans and other organisms. This information offers great opportunities for improving our understanding of complex diseases such as lung cancer. In particular, we should expect to witness a rapid increase in the rate of discovery of genes involved in lung cancer pathogenesis and we should be able to develop reliable molecular criteria for classifying lung cancers and predicting biological properties of individual tumors. Achieving these goals will require collaboration by scientists with specialized expertise in medicine, molecular biology, and decision-based statistical analysis.

Edward Gabrielson

2000-01-01T23:59:59.000Z

292

Averaging-Related Biases in Monthly Latent Heat Fluxes  

Science Conference Proceedings (OSTI)

Seasonal-to-multidecadal applications that require ocean surface energy fluxes often require accuracies of surface turbulent fluxes to be 5 W m?2 or better. While there is little doubt that uncertainties in the flux algorithms and input data can ...

Paul J. Hughes; Mark A. Bourassa; Jeremy J. Rolph; Shawn R. Smith

2012-07-01T23:59:59.000Z

293

Dynamic social network analysis using latent space models  

Science Conference Proceedings (OSTI)

This paper explores two aspects of social network modeling. First, we generalize a successful static model of relationships into a dynamic model that accounts for friendships drifting over time. Second, we show how to make it tractable to learn such ...

Purnamrita Sarkar; Andrew W. Moore

2005-12-01T23:59:59.000Z

294

Middle Atmospheric Traveling Waves Forced by Latent and Convective Heating  

Science Conference Proceedings (OSTI)

The excitation and propagation of equatorial planetary waves and inertia-gravity waves were studied by comparing simulations from the comprehensive GFDL troposphere-stratosphere-mesosphere SKYHI general circulation model (GCM) and from a linear ...

Elisa Manzini; Kevin Hamilton

1993-07-01T23:59:59.000Z

295

Joint latent topic models for text and citations  

Science Conference Proceedings (OSTI)

In this work, we address the problem of joint modeling of text and citations in the topic modeling framework. We present two different models called the Pairwise-Link-LDA and the Link-PLSA-LDA models. The Pairwise-Link-LDA model combines the ideas of ... Keywords: LDA, PLSA, citations, hyperlinks, influence, topic models, variational inference

Ramesh M. Nallapati; Amr Ahmed; Eric P. Xing; William W. Cohen

2008-08-01T23:59:59.000Z

296

Radar-Derived Estimates of Latent Heating in the Subtropics  

Science Conference Proceedings (OSTI)

Atmospheric warming from cloud heating has a major affect on worldwide atmospheric circulations and climate. Studies have shown that the dominant source for cloud heating is the phase change of water. The location and magnitude of cloud heating ...

Tina J. Cartwright; Peter S. Ray

1999-05-01T23:59:59.000Z

297

Latent Print Examination and Human Factors: Improving the ...  

Science Conference Proceedings (OSTI)

... and Investigative Genetics, University of North Texas Health ... Committee on Quality of Health Care in America. ... A Study of the American Academy of ...

2012-05-01T23:59:59.000Z

298

The Latent Process Decomposition of cDNA Microarray Datasets  

E-Print Network (OSTI)

Rogers,S. Girolami,M. Campbell,C. Breitling,R. IEEE/ACM Transactions on Computational Biology and Bioinformatics, Volume 2, Number 2. pp 143-156 IEEE Computer Society Press

Rogers, S.; Girolami, M.

299

Latent heat fluxes through nano-engineered porous materials  

E-Print Network (OSTI)

Micro- and nano-scale truss architectures provide mechanical strength, light weight, and breatheability in polymer barriers. Liquid evaporation and transport of resulting vapor through truss voids (pores) cools surfaces ...

Traum, Matthew J. (Matthew Jason), 1977-

2007-01-01T23:59:59.000Z

300

Relating Convective and Stratiform Rain to Latent Heating  

Science Conference Proceedings (OSTI)

The relationship among surface rainfall, its intensity, and its associated stratiform amount is established by examining observed precipitation data from the Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (PR). The results show ...

Wei-Kuo Tao; Stephen Lang; Xiping Zeng; Shoichi Shige; Yukari Takayabu

2010-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Energy Balance Models Incorporating Transport of Thermal and Latent Energy  

Science Conference Proceedings (OSTI)

Standard latitudinally resolved energy balance models describe conservation of energy on a sphere subject to solar heating, cooling by infrared radiation and diffusive redistribution of energy according to a Fourier type heat flow with flux ...

Brian P. Flannery

1984-02-01T23:59:59.000Z

302

Diffracted light from latent images in photoresist for exposure control  

DOE Patents (OSTI)

In microelectronics manufacturing, an arrangement for monitoring and control of exposure of an undeveloped photosensitive layer on a structure susceptible to variations in optical properties in order to attain the desired critical dimension for the pattern to be developed in the photosensitive layer. This is done by ascertaining the intensities for one or more respective orders of diffracted power for an incident beam of radiation corresponding to the desired critical dimension for the photosensitive layer as a function of exposure time and optical properties of the structure, illuminating the photosensitive layer with a beam of radiation of one or more frequencies to which the photosensitive layer is not exposure-sensitive, and monitoring the intensities of the orders of diffracted radiation due to said illumination including at least the first order of diffracted radiation thereof, such that when said predetermined intensities for the diffracted orders are reached during said illumination of photosensitive layer, it is known that a pattern having at least approximately the desired critical dimension can be developed on the photosensitive layer.

Bishop, Kenneth P. (Rio Rancho, NM); Brueck, Steven R. J. (Albuquerque, NM); Gaspar, Susan M. (Albuquerque, NM); Hickman, Kirt C. (Albuquerque, NM); McNeil, John R. (Albuquerque, NM); Naqvi, S. Sohail H. (Albuquerque, NM); Stallard, Brian R. (Albuquerque, NM); Tipton, Gary D. (Albuquerque, NM)

1997-01-01T23:59:59.000Z

303

Self-reported chemicals exposure, beliefs about disease causation, and risk of breast cancer in the Cape Cod Breast Cancer and Environment Study: a case-control study  

E-Print Network (OSTI)

2&1&0&1&6&0]. 34. Cape Cod Breast Cancer and the EnvironmentSpring Institute: Cape Cod Breast Cancer and Environmentbetween residence on Cape Cod, Massachusetts, and breast

Zota, Ami R; Aschengrau, Ann; Rudel, Ruthann A; Brody, Julia

2010-01-01T23:59:59.000Z

304

The relationship of cognitive, emotional, and interpersonal factors to screening and health-promoting behaviors among sisters of breast cancer patients.  

E-Print Network (OSTI)

??While sisters of breast cancer patients are at increased risk for developing breast cancer due to their family cancer history and age, little research with… (more)

Hartman, Sheri Jacobs

2008-01-01T23:59:59.000Z

305

DOE Laboratories Help Develop Promising New Cancer Fighting Drug,  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Laboratories Help Develop Promising New Cancer Fighting Drug, Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm Addthis Powerful X-Rays Enable Development of Successful Treatment for Melanoma and Other Life-Threatening Diseases WASHINGTON, DC - Powerful X-ray technology developed at the U.S. Department of Energy's (DOE's) national laboratories is revealing new insights into diseases ranging from Alzheimer's to the swine flu, and, most recently, enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, the deadliest form of skin cancer. The drug, Zelboraf (vemurafenib), received Food and Drug Administration (FDA) approval on Wednesday. In showing the structures of diseased and

306

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Print Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

307

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Print Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

308

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Print Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

309

A Targeted Cancer Treatment using Nanomaterials | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

When Roots Follow the Path of Least Resistance When Roots Follow the Path of Least Resistance Perfecting Catalytic Arrays A Stable Open Framework with Wide Open Spaces Pumping Through the Middle Crust Looking for Ways to Improve Vaccines Against the Deadly Rotavirus Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Targeted Cancer Treatment using Nanomaterials AUGUST 27, 2009 Bookmark and Share Optical fluorescent imaging of the TiO2-mAb binding to the single brain cancer cells. The bare titianium dioxide nanoparticle bonds with an antibody and attaches itself to brain cancer cells. When exposed to concentrated white light, the titanium dioxide creates free radicals of oxygen that cause the cancer cells to die. Image courtesy of Argonne

310

Breaking a Pocket of Resistance in the Fight Against Cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

Breaking a Pocket of Resistance in Breaking a Pocket of Resistance in the Fight Against Cancer Breaking a Pocket of Resistance in the Fight Against Cancer Print Thursday, 12 December 2013 11:55 ras protein The new class of inhibitors interacts with a specific mutation (Glycine to Cysteine) associated with a number of types of lung cancer. Mutations in the protein K-RAS are a very common cause for certain types of human cancers and are generally associated with a poor response to standard therapies. RAS, an abbreviation of Rat Sarcoma, is a nucleotide binding protein that responds to chemical signals (nucleotides). When in the "on" state, RAS activates other proteins, resulting in a cascade of biochemical processes; in the "off" state, RAS remains inactive. Mutations in the RAS

311

Evaluation of nanoparticles-based thermotherapy for cancer  

E-Print Network (OSTI)

Under alternating magnetic field, superparamagnetic iron oxide nanoparticles can be used to generate heat for the treatment of cancer. With suitable coating, these nanoparticles are biocompatible, stable in solution, and ...

Wiryaatmadja, Edwina

2007-01-01T23:59:59.000Z

312

Iran Thomas Auditorium, 8600 Fighting Cancer with Nanoparticle...  

NLE Websites -- All DOE Office Websites (Extended Search)

October 13, 2011 4:00 pm Iran Thomas Auditorium, 8600 Fighting Cancer with Nanoparticle Medicines Mark E. Davis Chemical Engineering California Institute of Technology CNMS D D I I...

313

Lung cancer epidemiology in New Mexico uranium miners  

SciTech Connect

This investigation assesses the health effects of radon progeny exposure in New Mexico uranium miners. Cumulative exposures sustained by most New Mexico miners are well below those received earlier in the Colorado Plateau. This project utilizes the research opportunity offered by New Mexico miners to address unresolved issues related to radon progeny exposure: (1) the lung cancer risk of lower levels of exposure, (2) interaction between radon progeny exposure and cigarette smoking in the causation of lung cancer, (3) the relationship between lung cancer histologic type and radon progeny exposure, and (4) possible effects of radon progeny exposure other than lung cancer. A cohort study of 3800 men with at least one year of underground uranium mining experience in New Mexico is in progress. Results are discussed.

Samet, J.M.

1991-11-01T23:59:59.000Z

314

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism...

315

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioscience Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair...

316

Analysis of alterations in the human cancer genome  

E-Print Network (OSTI)

Aneuploidy, an abnormal complement of chromosomes, is present in approximately 90% of human malignancies. Despite over 100 years of research, many questions remain regarding the contribution of aneuploidy to the cancer ...

Carter, Scott L. (Scott Lambert)

2011-01-01T23:59:59.000Z

317

Research Sheds Light on Workings of Anti-cancer Drug  

NLE Websites -- All DOE Office Websites (Extended Search)

Research Sheds Light on Workings of Anti-cancer Drug The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson...

318

Nested methylation-specific polymerase chain reaction cancer detection method  

DOE Patents (OSTI)

A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

2007-05-08T23:59:59.000Z

319

Investigating immune surveillance, tolerance, and therapy in cancer  

E-Print Network (OSTI)

Maximizing the potential of cancer immunotherapy requires model systems that closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems ...

Cheung, Ann F

2009-01-01T23:59:59.000Z

320

DOE Laboratories Help Develop Promising New Cancer Fighting Drug,  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Laboratories Help Develop Promising New Cancer Fighting Drug, Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm Addthis Powerful X-Rays Enable Development of Successful Treatment for Melanoma and Other Life-Threatening Diseases WASHINGTON, DC - Powerful X-ray technology developed at the U.S. Department of Energy's (DOE's) national laboratories is revealing new insights into diseases ranging from Alzheimer's to the swine flu, and, most recently, enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, the deadliest form of skin cancer. The drug, Zelboraf (vemurafenib), received Food and Drug Administration (FDA) approval on Wednesday. In showing the structures of diseased and

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Print Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

322

Arsenic Cancer Risk Assessment: Recent Advances & Next Steps  

Science Conference Proceedings (OSTI)

In recent years, there has been an on-going debate on the appropriate regulatory approach for evaluating the carcinogenicity of inorganic arsenic compounds, specifically in the best methods and data sources for establishing a cancer potency, or cancer slope factor (CSF). The CSF is applied to the development of environmental standards, regulation and risk assessments under a variety of federal and state programs. Currently, the U.S. Environmental Protection Agency (EPA) continues to rely on chemical non-...

2011-12-30T23:59:59.000Z

323

Tanikawa C et al. Mol Cancer Res 8: 855-863, 2010. Tanikawa C et al. Cancer Res 69: 8761-9, 2009.  

E-Print Network (OSTI)

p53 p53 30000 p53 Tanikawa C et al. Mol Cancer Res 8: 855-863, 2010. Tanikawa C et al. Cancer Res 69: 8761-9, 2009. Tanikawa C et al.Oncogene 28: 3081-92, 2009. Morioka K et al. Cancer Science 100: 1227-1233, 2009. Kidokoro T et al. Oncogene 27: 1562-1571, 2008

Katsumoto, Shingo

324

What is the probability that radiation caused a particular cancer  

SciTech Connect

Courts, lawyers, health physicists, physicians, and others are searching for a credible answer to the question posed in the title of this paper. The cases in which the question arises frequently stem from an individual that has cancer and they, or their next-of-kin, are convinced that a past radiation exposure - usually small - is responsible for causing it. An arithmetic expression of this problem is simple: the probability of causation by the radiation dose in question is equal to the risk of cancer from the radiation dose divided by the risk of cancer from all causes. The application of risk factors to this equation is not so simple. It must involve careful evaluation of the reliability of and variations in risk coefficients for development of cancer due to radiation exposure, other carcinogenic agents, and natural causes for the particular individual. Examination of our knowledge of these various factors indicates that a large range in the answers can result due to the variability and imprecision of the data. Nevertheless, the attempts to calculate and the probability that radiation caused the cancer is extremely useful to provide a gross perspective on the probability of causation. It will likely rule in or out a significant number of cases despite the limitations in our understandings of the etiology of cancer and the risks from various factors. For the remaining cases, a thoughtful and educated judgment based on selected data and circumstances of the case will also be needed before the expert can develop and support his opinion.

Voelz, G.L.

1983-01-01T23:59:59.000Z

325

Carbon Ion Radiotherapy At Gunma University: Currently Indicated Cancer And Estimation Of Need  

SciTech Connect

Carbon ion radiotherapy for the first patient at Gunma University Heavy Ion Medical Center (GHMC) was initiated in March of 2010. The major specifications of the facility were determined based on the experience of clinical treatments at National Institute of Radiological Sciences (NIRS). The currently indicated sites of cancer treatment at GHMC are lung, prostate, head and neck, liver, rectum, bone and soft tissue. In order to evaluate the potential need for treatment in the region including Gunma prefecture and the adjacent 4 prefectures, an estimation model was constructed based on the Japanese cancer registration system, regular structure surveys by the Cancer Societies, and published articles on each cancer type. Carbon ion RT was potentially indicated for 8,085 patients and realistically for 1,527 patients, corresponding to 10% and 2% of the newly diagnosed cancer patients in the region. Prostate cancer (541 patients) followed by lung cancer (436 patients), and liver cancer (313 patients) were the most commonly diagnosed cancers.

Ohno, Tatsuya; Nakano, Takashi; Kanai, Tatsuaki; Yamada, Satoru [Gunma University Heavy Ion Medical Center, Gunma University, 3-39-22 Showa, Maebashi 371-8511 (Japan)

2011-06-01T23:59:59.000Z

326

Volumetric modulated arc radiotherapy for esophageal cancer  

SciTech Connect

A treatment planning study was performed to evaluate the performance of volumetric arc modulation with RapidArc (RA) against 3D conformal radiation therapy (3D-CRT) and conventional intensity-modulated radiation therapy (IMRT) techniques for esophageal cancer. Computed tomgraphy scans of 10 patients were included in the study. 3D-CRT, 4-field IMRT, and single-arc and double-arc RA plans were generated with the aim to spare organs at risk (OAR) and healthy tissue while enforcing highly conformal target coverage. The planning objective was to deliver 54 Gy to the planning target volume (PTV) in 30 fractions. Plans were evaluated based on target conformity and dose-volume histograms of organs at risk (lung, spinal cord, and heart). The monitor unit (MU) and treatment delivery time were also evaluated to measure the treatment efficiency. The IMRT plan improves target conformity and spares OAR when compared with 3D-CRT. Target conformity improved with RA plans compared with IMRT. The mean lung dose was similar in all techniques. However, RA plans showed a reduction in the volume of the lung irradiated at V{sub 20Gy} and V{sub 30Gy} dose levels (range, 4.62-17.98%) compared with IMRT plans. The mean dose and D{sub 35%} of heart for the RA plans were better than the IMRT by 0.5-5.8%. Mean V{sub 10Gy} and integral dose to healthy tissue were almost similar in all techniques. But RA plans resulted in a reduced low-level dose bath (15-20 Gy) in the range of 14-16% compared with IMRT plans. The average MU needed to deliver the prescribed dose by RA technique was reduced by 20-25% compared with IMRT technique. The preliminary study on RA for esophageal cancers showed improvements in sparing OAR and healthy tissue with reduced beam-on time, whereas only double-arc RA offered improved target coverage compared with IMRT and 3D-CRT plans.

Vivekanandan, Nagarajan, E-mail: viveknaren@hotmail.com [Department of Medical Physics, Cancer Institute, Chennai (India); Sriram, Padmanaban; Syam Kumar, S.A.; Bhuvaneswari, Narayanan; Saranya, Kamalakannan [Department of Medical Physics, Cancer Institute, Chennai (India)

2012-04-01T23:59:59.000Z

327

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the Breast Cancer Association Consortium: a combined case-control study  

E-Print Network (OSTI)

7HT, UK. Breakthrough Breast Cancer Research Centre, TheInstitute of Cancer Research, 237 Fulman Road, London,control study. Breast Cancer Research 2010 12:R110. Submit

2010-01-01T23:59:59.000Z

328

East-West Symposium on nasopharyngeal cancer  

Science Conference Proceedings (OSTI)

Background: To achieve greater understanding of the epidemiology, pathogenesis, molecular oncology, diagnostic, and therapeutic aspects of nasopharyngeal cancer (NPC), an international meeting was held in June 2005, Toronto, Canada. Results: Further insights were obtained into the role of EBV in NPC development, with its diverse effects ranging from proliferative signals via NF-kB, to immunesuppression, to angiogenic gene regulation. Subsequently, multiple pathways are dysregulated in NPC as revealed by expression array analyses, including apoptosis, integrin, and B-catenin cascades. Advances have been made in the diagnosis and monitoring of NPC, using transoral brushings and plasma levels of EBV transcripts, which may not directly correlate with the number of circulating tumor cells, but is nevertheless informative in predicting and tracking disease response. Many novel therapies have promising results, particularly in the areas of immunotherapies, and the exploration of molecularly targeted approaches such as cetuximab or histone deacetylase inhibitors. Conclusions: The results from large randomized trials and meta-analyses have consistently demonstrated the benefit of concurrent chemotherapy with curative radiation therapy, but at a cost of greater acute and late-tissue toxicities. Further advances are required to achieve an improved understanding on the inter-relationship between environmental and genetic determinants in NPC development, to reduce the global burden of this disease. At the same time, novel therapeutic approaches are necessary to increase curability of NPC, but with reduced long-term toxicities.

Liu, F.-F. [Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto (Canada) and Department of Radiation Oncology, University of Toronto, Toronto (Canada) and Division of Applied Molecular Oncology, Ontario Cancer Institute, Ontario (Canada) and Department of Medical Biophysics, University of Toronto, Toronto (Canada)]. E-mail: Fei-Fei.Liu@rmp.uhn.on.ca; Frappier, Lori [Department of Microbiology, University of Toronto, Toronto (Canada); Kim, John [Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Radiation Oncology, University of Toronto, Toronto (Canada); O'Sullivan, Brian [Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Radiation Oncology, University of Toronto, Toronto (Canada); Hui, Angela [Division of Applied Molecular Oncology, Ontario Cancer Institute, Ontario (Canada); Department of Medical Biophysics, University of Toronto, Toronto (Canada); Bastianutto, Carlo [Division of Applied Molecular Oncology, Ontario Cancer Institute, Ontario (Canada); Department of Medical Biophysics, University of Toronto, Toronto (Canada)

2007-03-01T23:59:59.000Z

329

Ozone, skin cancer, and the SST  

SciTech Connect

In 1971, the U.S. Congress cut off funding for development of supersonic transport aircraft prototypes when it was argued that the pollution created by SSTs could reduce the stratospheric ozone content and increase the incidence of skin cancer. At present, the theory of ozone depletion is in a rather uncertain state. Two examples of this are cited. First, ozone depletion may depend more on the availability of surfaces of aerosols and particles than on the content of chlorine. Second, it has been discovered that NO(x) can tie up active chlorine and thus reduce depletion from that source. We are therefore left with the paradoxical result that under certain circumstances SSTs flying in the lower stratospheric can actually counteract, at least partially, any ozone-depleting effects of CFCs. A recent study by scientists at the Brookhaven National Laboratory showed that melanoma rates would not be affected by changes in the ozone layer. If these results are confirmed, then much of the fear associated with ozone depletion disappears. It is difficult to tell how all this will affect a future supersonic transport program, since it is not clear whether a fleet of SSTs will increase or offset ozone depletion.

Singer, S.F.

1994-07-01T23:59:59.000Z

330

Modulation of the HGF/c-Met/Akt and p38 cell signaling pathways by 3,3'-diindolylmethane in MDA-MB-231 breast cancer cells  

E-Print Network (OSTI)

24 and perillyl alcohol. Cancer research 68: 7439-in breast cancer cells. Cancer research 66: 4952-4960. 49.through the Akt pathway. Cancer research 60: 6841-6845. 66.

Nicastro, Holly

2010-01-01T23:59:59.000Z

331

The prognostic significance of tumor cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients  

E-Print Network (OSTI)

American Association of Cancer Research Annual Meeting 2008cancer patients. Breast Cancer Research 2011 13:R61. SubmitMolloy et al. Breast Cancer Research 2011, 13:R61 http://

2011-01-01T23:59:59.000Z

332

BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer  

E-Print Network (OSTI)

in a case of post-Chernobyl childhood thyroid cancer *D. Thyroid cancer after Chernobyl. Nature 1992;359:21-22. [LN. Thyroid cancer after Chernobyl. Nature [4] Gembicki M,

Kwan, Johnson

2010-01-01T23:59:59.000Z

333

An optimized five-gene multi-platform predictor of hormone receptor negative and triple negative breast cancer metastatic risk  

E-Print Network (OSTI)

5 Breakthrough Breast Cancer Research Unit, Guy’ s Hospital,metastatic risk. Breast Cancer Research 2013 15:R103. SubmitYau et al. Breast Cancer Research 2013, 15:R103 http://

2013-01-01T23:59:59.000Z

334

Cyclophosphamide- metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study  

E-Print Network (OSTI)

cohort study Breast Cancer Research 2010, 12:R26How- Gor et al. Breast Cancer Research 2010, 12:R26 http://OS. Gor et al. Breast Cancer Research 2010, 12:R26 http://

2010-01-01T23:59:59.000Z

335

Residential radon and lung cancer incidence in a Danish cohort  

SciTech Connect

High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993-1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed. Median estimated radon was 35.8 Bq/m{sup 3}. The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69-1.56) in association with a 100 Bq/m{sup 3} higher radon concentration and 1.67 (95% CI: 0.69-4.04) among non-smokers. We found no evidence of effect modification. We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

Braeuner, Elvira V., E-mail: ole@cancer.dk [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Danish Building Research Institute, Aalborg University (Denmark); Andersen, Claus E. [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark)] [Center for Nuclear Technologies, Radiation Research Division, Riso National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde (Denmark); Sorensen, Mette [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Jovanovic Andersen, Zorana [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark) [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Center for Epidemiology Screening, Department of Public Health, University of Copenhagen (Denmark); Gravesen, Peter [Geological Survey of Denmark and Greenland, Copenhagen (Denmark)] [Geological Survey of Denmark and Greenland, Copenhagen (Denmark); Ulbak, Kaare [National Institute of Radiation Protection, Herlev (Denmark)] [National Institute of Radiation Protection, Herlev (Denmark); Hertel, Ole [Department of Environmental Science, Aarhus University, Aarhus (Denmark)] [Department of Environmental Science, Aarhus University, Aarhus (Denmark); Pedersen, Camilla [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark); Overvad, Kim [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark)] [Department of Epidemiology, School of Public Health, Aarhus University, Aarhus (Denmark); Tjonneland, Anne; Raaschou-Nielsen, Ole [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)] [Diet, Genes and Environment, Danish Cancer Society Research Centre, Copenhagen (Denmark)

2012-10-15T23:59:59.000Z

336

Cancer and work in Canada with particular reference to occupational risk factors in breast cancer patients in one community and related selected research methods used to investigate those factors.  

E-Print Network (OSTI)

??Cancer represents a major cause of human morbidity and mortality. There is no scientific consensus regarding cancer causality or prevention. Occupational exposure potentially remains a… (more)

Brophy, James Thomas

2004-01-01T23:59:59.000Z

337

Approaches to the Spatial Modelling of Cancer Incidence and Mortality in Metropolitan Perth, Western Australia, 1990 -2005.  

E-Print Network (OSTI)

??Cancer is one of potentially preventable and treatable diseases. Cancer analysis from different perspectives is necessary to provide the information for health research and the… (more)

Shao, Changying

2011-01-01T23:59:59.000Z

338

How much is a health insurer willing to pay for colorectal cancer screening tests?  

Science Conference Proceedings (OSTI)

Colorectal Cancer (CRC) screening tests have proven to be cost-effective in preventing cancer incidence. Yet, as recent studies have shown, CRC screening tests are noticeably underutilized. Among the factors influencing CRC screening test utilization, ...

Reza Yaesoubi; Stephen D. Roberts

2008-12-01T23:59:59.000Z

339

APPLYING DATA MINING TECHNIQUES FOR CANCER CLASSIFICATION ON GENE EXPRESSION DATA  

Science Conference Proceedings (OSTI)

Cancer classification through gene expression data analysis has recently emerged as an active area of research. This paper applies Genetic Algorithms (GA) for selecting a group of relevant genes from cancer microarray data. Then, the popular classifiers, ...

Jinn-Yi Yeh

2008-08-01T23:59:59.000Z

340

Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery  

E-Print Network (OSTI)

The identification of cancer drivers is a major goal of current cancer research. Finding driver genes within large chromosomal events is especially challenging because such alterations encompass many genes. Previously, we ...

Zhang, GuangJun

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Editorial Breast cancer stem cell markers- the rocky road to clinical  

E-Print Network (OSTI)

Lately, understanding the role of cancer stem cells in tumor initiation and progression became a major focus in stem cell biology and in cancer research. Considerable efforts, such as the recent studies by Honeth and colleagues, published in the June issue of Breast Cancer Research, are directed towards developing clinical applications of the cancer stem cell concepts. This work shows that the previously described CD44+CD24- stem cell phenotype is associated with basal-type breast cancers in human patients, in particular BRCA1 inherited cancers, but does not correlate with clinical outcome. These very interesting findings caution that the success of our efforts in translating cancer stem cell research into clinical practice depends on how thorough and rigorous we are at characterizing these cells. The cancer stem cell model, a concept initially proposed

Gabriela Dontu

2008-01-01T23:59:59.000Z

342

Comparative meta-analysis between human and mouse cancer microarray data reveals critical pathways  

Science Conference Proceedings (OSTI)

Identification of deregulated biomolecular pathways in cancer may be more important than identification of individual genes through differential expression. We have analysed data from 87 microarray datasets, spanning 25 different types of cancer, and ...

Pankaj Chopra; Jaewoo Kang; Seung-Mo Hong

2013-08-01T23:59:59.000Z

343

A general method for studying autocrine signaling and its impact on cancer cell growth  

E-Print Network (OSTI)

Autocrine signaling plays essential roles in providing self-sustaining growth signals to cancer cells. Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine signaling in cancer medicine ...

Sampattavanich, Somponnat

2011-01-01T23:59:59.000Z

344

High-order chromatin architecture determines the landscape of chromosomal alterations in cancer  

E-Print Network (OSTI)

The accumulation of data on structural variation in cancer genomes provides an opportunity to better understand the mechanisms of genomic alterations and the forces of selection that act upon these alterations in cancer. ...

Fudenberg, Geoff

345

Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells  

E-Print Network (OSTI)

Background: Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical ...

Papa, Anne-Laure

346

DOE Research Contributions to Radiation and Cancer Therapy  

NLE Websites -- All DOE Office Websites (Extended Search)

DOE Research Contributions to Radiation and Cancer Therapy Resources with Additional Information Planned radiation treatment Peregrine calculation from Mission Possible: DOE Advanced Biomedical Technology Research, page 10 Over the time span of many years, DOE's research has made many contributions to radiation and cancer therapy, including PEREGRINE and Boron Neutron Capture Therapy (BNCT). 'PEREGRINE, a hardware and software system that addresses the problem of radiation therapy dosage using fundamental physics principles, is a revolutionary new tool for analyzing and planning radiation treatment for cancer patients. About 90 percent of radiation treatment patients receive photon therapy, which is PEREGRINE's principal application. PEREGRINE may also be applied to the less frequently used electron-beam therapy and to brachytherapy, which is radiation therapy from an internally planted radiation source. It is effective for radiography, which predicts the pattern of radiation that is transmitted through a patient or other object.'1

347

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioscience Bioscience Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

348

Adapting a Program to Inform African American and Hispanic American Women About Cancer Clinical Trials  

E-Print Network (OSTI)

to participate in medical research studies. Ann Epidemiolto participate in medical research studies. Cancer 91(1

2010-01-01T23:59:59.000Z

349

Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting  

E-Print Network (OSTI)

GA, USA. 14 Sidra Medical and Research, Centre, Doha, Qatar.Medical Center, Chicago, IL, USA. 12 Cancer Immunology Research

2013-01-01T23:59:59.000Z

350

A novel cognitive interpretation of breast cancer thermography with complementary learning fuzzy neural memory structure  

Science Conference Proceedings (OSTI)

Early detection of breast cancer is the key to improve survival rate. Thermogram is a promising front-line screening tool as it is able to warn women of breast cancer up to 10 years in advance. However, analysis and interpretation of thermogram are heavily ... Keywords: Breast cancer diagnosis, Complementary learning, FALCON-AART, Fuzzy adaptive learning control network fuzzy neural network, Thermogram

T. Z. Tan; C. Quek; G. S. Ng; E. Y. K. Ng

2007-10-01T23:59:59.000Z

351

Contribution of the PALB2 c.2323C>T [p. Q775X] Founder mutation in well-defined breast and/or ovarian cancer families and unselected ovarian cancer cases of French Canadian descent  

E-Print Network (OSTI)

] mutation carrier fam carrier in family F1469. Abbreviations: bilateral breast cancer (Bi Br), cerebra melanoma (Mel), stomach cancer (Sto), and uterine cancer (Ut). Age at asce diagnosis of cancer. Tischkowitz et al. BMC Medical Genetics 2013, 14:5 Page 4...

Tischkowitz, Marc; Sabbaghian, Nelly; Hamel, Nancy; Pouchet, Carly; Foulkes, William D; Mes-Masson, Anne-Marie; Provencher, Diane M; Tonin, Patricia N

2013-01-09T23:59:59.000Z

352

EPA 402-R-93-076 ESTIMATING RADIOGENIC CANCER RISKS  

E-Print Network (OSTI)

, especially new information on the Japanese atomic bomb survivors. For most cancer sites, the risk model of coefficients derived from the atomic bomb survivor data employing two different methods for transporting risks 401 M Street S.W. Washington, DC 20460 #12;ii The scientific basis for this report has been reviewed

353

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Enzyme Structure Provides Insights into Cancer and Aging Enzyme Structure Provides Insights into Cancer and Aging Print Wednesday, 25 February 2009 00:00 XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

354

Design Ensemble Machine Learning Model for Breast Cancer Diagnosis  

Science Conference Proceedings (OSTI)

In this paper, we classify the breast cancer of medical diagnostic data. Information gain has been adapted for feature selections. Neural fuzzy (NF), k-nearest neighbor (KNN), quadratic classifier (QC), each single model scheme as well as their associated, ... Keywords: Ensemble learning, Information gain, KNN, Neural fuzzy, Quadratic classifier

Sheau-Ling Hsieh; Sung-Huai Hsieh; Po-Hsun Cheng; Chi-Huang Chen; Kai-Ping Hsu; I-Shun Lee; Zhenyu Wang; Feipei Lai

2012-10-01T23:59:59.000Z

355

Prostate cancer grading: Gland segmentation and structural features  

Science Conference Proceedings (OSTI)

In this paper, we introduce a novel approach to grade prostate malignancy using digitized histopathological specimens of the prostate tissue. Most of the approaches proposed in the literature to address this problem utilize various textural features ... Keywords: Benign, Carcinoma, Gland segmentation, Gleason grading system, Nuclei, Prostate cancer

Kien Nguyen; Bikash Sabata; Anil K. Jain

2012-05-01T23:59:59.000Z

356

Construction of SAGA HIMAT for carbon ion cancer therapy  

SciTech Connect

SAGA HIMAT is now under construction in Tosu city, Saga prefecture, Kyushu island, Japan. It will open in 2013 and become the fourth carbon ion beam cancer therapy center in Japan. It is a collaborative project among the local governments, industries and universities in northern Kyushu area.

Kudo, Sho; Shioyama, Yoshiyuki; Endo, Masahiro; Kanazawa, Mitsutaka; Tsujii, Hirohiko; Totoki, Tadahide [Ion Beam Therapy Center , SAGA HIMAT Foundation, 1-802-3 Hondori-machi, Tosu, Saga 841-0033 (Japan)

2013-04-19T23:59:59.000Z

357

Investigation of a bladder cancer cluster in northwestern Illinois  

SciTech Connect

Cancer maps from 1950 through 1979 revealed areas of high mortality from bladder cancer for both males and females in several northwestern Illinois counties. In order to further explore this excess, a bladder cancer incidence study was conducted in the eight counties comprising this region. Eligible cases were those first diagnosed with bladder cancer between 1978 and 1985. Age adjusted standardized incidence ratios were calculated for each county and for 97 zip codes within these counties. County results revealed no excesses. Zip code results indicated elevated risks in a few areas, but only two zip codes had significantly elevated results. One of these zip codes had a significant excess in males (standardized incidence ratio = 1.5) and females (standardized incidence ratio = 1.9). This excess was primarily confined to one town in this zip code, in which standardized incidence ratios were significantly elevated in males (1.7) and females (2.6). Further investigation revealed that one of four public drinking water wells in this town had been closed due to contamination; two wells were within a half mile (0.8 km) of a landfill site that had ceased operating in 1972. Tests of these two wells revealed traces of trichloroethylene, tetrachloroethylene, and other solvents. Further investigation of this cluster is discussed.

Mallin, K. (Illinois Cancer Council, Chicago (USA))

1990-07-01T23:59:59.000Z

358

Reflections in Mutation Research Electric light causes cancer?  

E-Print Network (OSTI)

]. And on a population level, there is a strong international correlation between estimates of per capita fat consumption) wasted energy, (3) harm to animal and plant life, (4) and perhaps increases in some severe human maladies dismayed by the recent reports that dietary fat consumption was unrelated to risk of breast cancer in women

Oliver, Douglas L.

359

Arsenic in drinking water and lung cancer: A systematic review  

SciTech Connect

Exposure to inorganic arsenic via drinking water is a growing public health concern. We conducted a systematic review of the literature examining the association between arsenic in drinking water and the risk of lung cancer in humans. Towards this aim, we searched electronic databases for articles published through April 2006. Nine ecological studies, two case-control studies, and six cohort studies were identified. The majority of the studies were conducted in areas of high arsenic exposure (100 {mu}g/L) such as southwestern Taiwan, the Niigata Prefecture, Japan, and Northern Chile. Most of the studies reported markedly higher risks of lung cancer mortality or incidence in high arsenic areas compared to the general population or a low arsenic exposed reference group. The quality assessment showed that, among the studies identified, only four assessed arsenic exposure at the individual level. Further, only one of the ecological studies presented results adjusted for potential confounders other than age; of the cohort and case-control studies, only one-half adjusted for cigarette smoking status in the analysis. Despite these methodologic limitations, the consistent observation of strong, statistically significant associations from different study designs carried out in different regions provide support for a causal association between ingesting drinking water with high concentrations of arsenic and lung cancer. The lung cancer risk at lower exposure concentrations remains uncertain.

Celik, Ismail [Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara (Turkey); Gallicchio, Lisa [Prevention and Research Center, Mercy Medical Center (United States); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Boyd, Kristina; Lam, Tram K.; Matanoski, Genevieve [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Tao Xuguang [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Department of Occupational and Environmental Medicine, Johns Hopkins University School of Medicine (United States); Shiels, Meredith; Hammond, Edward [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Chen Liwei [Department of International Health, Center for Human Nutrition, Johns Hopkins University Bloomberg School of Public Health (United States); Robinson, Karen A. [Department of General Internal Medicine, Johns Hopkins University School of Medicine (United States); Caulfield, Laura E. [Department of International Health, Center for Human Nutrition, Johns Hopkins University Bloomberg School of Public Health (United States); Herman, James G. [Department of Oncology, Johns Hopkins University School of Medicine (United States); Guallar, Eliseo [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Alberg, Anthony J. [Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (United States); Cancer Prevention and Control Program, Hollings Cancer Center, and Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina (United States)], E-mail: alberg@musc.edu

2008-09-15T23:59:59.000Z

360

Genetic heterogeneity in breast cancer: the road to personalized medicine?  

E-Print Network (OSTI)

-F, Kingsbury Z, Wong ASC, Marass F, Humphray S, Hadfield J, Bentley D, Chin TM, Brenton JD, Caldas C, Rosenfeld N: Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 2013, 497:108–112. 27. Farquhar C, Marjoribanks...

Baird, Richard D; Caldas, Carlos

2013-06-21T23:59:59.000Z

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361

CANCER CELL : SEPTEMBER 2005 175 Clinicians often diagnose tumors based  

E-Print Network (OSTI)

-based positive feedback control loop exists that can impact cell proliferation. In this issue of Cancer Cell that changes of ECM structure or mechanics, such as whether the matrix is stiff enough to resist cell traction forces, might actively contribute to tumor formation (Ingber et al., 1981). Alterations of mechani- cal

Ingber, Donald E.

362

ORIGINAL ARTICLE FER kinase promotes breast cancer metastasis by regulating  

E-Print Network (OSTI)

with normal prostate epithelium and regulates prostate cancer cell proliferation by activating signal-integrin-dependent cell adhesion and anoikis resistance IA Ivanova1 , JF Vermeulen1 , C Ercan1 , JM of new intervention strategies. Here, we show that FER kinase (FER) controls migration and metastasis

Cai, Long

363

The Narrative Construction of Breast Cancer: A Comparative Case Study of the Susan G. Komen Foundation and National Breast Cancer Coalisions' Campaign Strategies, Messages, and Effects.  

E-Print Network (OSTI)

??The goal of this research is to reveal the connections, contradictions, tensions, and paradoxes inherent in the narratives of breast cancer created by the Susan… (more)

Olson, Amanda M.

2005-01-01T23:59:59.000Z

364

Quantitative Resolution to some "Absolute Discrepancies" in Cancer Theories: a View from Phage lambda Genetic Switch  

E-Print Network (OSTI)

Is it possible to understand cancer? Or more specifically, is it possible to understand cancer from genetic side? There already many answers in literature. The most optimistic one has claimed that it is mission-possible. Duesberg and his colleagues reviewed the impressive amount of research results on cancer accumulated over 100 years. It confirms the a general opinion that considering all available experimental results and clinical observations there is no cancer theory without major difficulties, including the prevailing gene-based cancer theories. They have then listed 9 "absolute discrepancies" for such cancer theory. In this letter the quantitative evidence against one of their major reasons for dismissing mutation cancer theory, by both in vivo experiment and a first principle computation, is explicitly pointed out.

P. Ao

2007-04-03T23:59:59.000Z

365

Low Dose Radiation Cancer Risks: Epidemiological and Toxicological Models  

Science Conference Proceedings (OSTI)

The basic purpose of this one year research grant was to extend the two stage clonal expansion model (TSCE) of carcinogenesis to exposures other than the usual single acute exposure. The two-stage clonal expansion model of carcinogenesis incorporates the biological process of carcinogenesis, which involves two mutations and the clonal proliferation of the intermediate cells, in a stochastic, mathematical way. The current TSCE model serves a general purpose of acute exposure models but requires numerical computation of both the survival and hazard functions. The primary objective of this research project was to develop the analytical expressions for the survival function and the hazard function of the occurrence of the first cancer cell for acute, continuous and multiple exposure cases within the framework of the piece-wise constant parameter two-stage clonal expansion model of carcinogenesis. For acute exposure and multiple exposures of acute series, it is either only allowed to have the first mutation rate vary with the dose, or to have all the parameters be dose dependent; for multiple exposures of continuous exposures, all the parameters are allowed to vary with the dose. With these analytical functions, it becomes easy to evaluate the risks of cancer and allows one to deal with the various exposure patterns in cancer risk assessment. A second objective was to apply the TSCE model with varing continuous exposures from the cancer studies of inhaled plutonium in beagle dogs. Using step functions to estimate the retention functions of the pulmonary exposure of plutonium the multiple exposure versions of the TSCE model was to be used to estimate the beagle dog lung cancer risks. The mathematical equations of the multiple exposure versions of the TSCE model were developed. A draft manuscript which is attached provides the results of this mathematical work. The application work using the beagle dog data from plutonium exposure has not been completed due to the fact that the research project did not continue beyond its first year.

David G. Hoel, PhD

2012-04-19T23:59:59.000Z

366

Second cancer incidence risk estimates using BEIR VII models for standard and complex external beam radiotherapy for early breast cancer  

Science Conference Proceedings (OSTI)

Purpose: To compare organ specific cancer incidence risks for standard and complex external beam radiotherapy (including cone beam CT verification) following breast conservation surgery for early breast cancer.Method: Doses from breast radiotherapy and kilovoltage cone beam CT (CBCT) exposures were obtained from thermoluminescent dosimeter measurements in an anthropomorphic phantom in which the positions of radiosensitive organs were delineated. Five treatment deliveries were investigated: (i) conventional tangential field whole breast radiotherapy (WBRT), (ii) noncoplanar conformal delivery applicable to accelerated partial beast irradiation (APBI), (iii) two-volume simultaneous integrated boost (SIB) treatment, (iv) forward planned three-volume SIB, and (v) inverse-planned three volume SIB. Conformal and intensity modulated radiotherapy methods were used to plan the complex treatments. Techniques spanned the range from simple methods appropriate for patient cohorts with a low cancer recurrence risk to complex plans relevant to cohorts with high recurrence risk. Delineated organs at risk included brain, salivary glands, thyroid, contralateral breast, left and right lung, esophagus, stomach, liver, colon, and bladder. Biological Effects of Ionizing Radiation (BEIR) VII cancer incidence models were applied to the measured mean organ doses to determine lifetime attributable risk (LAR) for ages at exposure from 35 to 80 yr according to radiotherapy techniques, and included dose from the CBCT imaging. Results: All LAR decreased with age at exposure and were lowest for brain, thyroid, liver, and bladder (cancer incidence for organs distant from the treated breast, or the contralateral breast where appropriate plan constraints are applied. Complex SIB treatments are predicted to increase the risk of second cancer incidence in the lungs compared to standard whole breast radiotherapy; this is outweighed by the threefold reduction in 5 yr local recurrence risk for patients of high risk of recurrence, and young age, from the use of radiotherapy. APBI may have a favorable impact on risk of second cancer in the contralateral breast and lung for older patients at low risk of recurrence. Intensive use of IGRTincreased the estimated values of LAR but these are dominated by the effect of the dose from the radiotherapy, and any increase in LAR from IGRT is much lower than the models' uncertainties.

Donovan, E. M.; James, H.; Bonora, M.; Yarnold, J. R.; Evans, P. M. [Joint Department of Physics, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton SM2 5PT (United Kingdom); Physics Department, Ipswich Hospital NHS Foundation Trust, Ipswich IP4 5PD (United Kingdom); Department of Academic Radiotherapy, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton SM2 5PT, United Kingdom and School of Radiotherapy, University of Milan, Milan 20122 (Italy); Department of Academic Radiotherapy, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton SM2 5PT (United Kingdom); Centre for Vision Speech and Signal Processing, University of Surrey, Guildford GU2 7XH (United Kingdom)

2012-10-15T23:59:59.000Z

367

New synthetic derivatives of triterpenoids in the treatment of cancer  

E-Print Network (OSTI)

Methyl 2-cyano-3,11-dioxo-18?-olean-1,12-dien-30-oate (?-CDODA-Me) and methyl 2-cyano-3,11-dioxo-18?-olean-1,12-dien-30-oate (?-CDODA-Me ) isomers are synthetic analogs of the naturally occurring triterpenoid glycyrrhetinic acid. The activity of these compounds as selective peroxisome proliferator-activated receptor ? (PPAR?) agonists and as cytotoxic anticancer agents has been investigated in colon, prostate and pancreatic cancer cells. In colon cancer cells ?-CDODA-Me arrested the growth at G2/M and this was accompanied by decreased expression of Sp1, Sp3 and Sp4 protein and mRNA and several Sp-dependent genes including survivin, vascular endothelial growth factor (VEGF), and VEGF receptor 1 (VEGFR1 or Flt-1). ?-CDODA-Me also inhibited tumor growth in athymic nude mice bearing RKO cells as xenografts. ?- CDODA-Me decreased expression of microRNA-27a (miR-27a), and this was accompanied by increased expression of two miR-27a-regulated mRNAs, namely ZBTB10 (an Sp repressor) and Myt-1 which catalyzes phosphorylation of cdc2 to inhibit progression of cells through G2/M. In LNCaP prostate cancer cells induction of two proapoptotic proteins namely nonsteroidal anti-inflammatory drug- activated gene-1 (NAG-1) and activating transcription factor-3 (ATF-3) was PPAR? independent and required activation of kinases. ?-CDODA-Me also decreased the levels of androgen receptor (AR) and prostate-specific antigen (PSA) mRNA and protein levels. Thus the cytotoxicity of ?- CDODA-Me involved multiple pathways that selectively activate growth inhibitory and proapoptotic responses. Betulinic acid (BA), an inhibitor of melanoma is a pentacyclic triterpenoid natural product that induces apoptosis and antiangiogenic responses in tumors derived from multiple tissues. However, the underlying mechanism of action of BA is unknown. In LNCaP prostate cancer cells, BA acts as a novel anticancer agent by inducing proteasome-dependent repression of Sp proteins and Sp- dependent genes. The anticancer activity of the 2-cyano substituted analogs of BA, CN-BA and its methyl ester, CN-BA-Me was also investigated in colon and pancreatic cancer cells. Both CNBA and CN-BA-Me were highly cytotoxic and activated PPAR? and induced several receptor-mediated responses. The results clearly demonstrated that both the PPAR? agonist activities of CN-BA and CN-BA-Me were structure-, response-/gene- and cell context-dependent suggesting that these compounds are a novel class of selective PPAR? modulators with potential for clinical treatment of prostate, colon and pancreatic cancer.

Papineni, Sabitha

2008-12-01T23:59:59.000Z

368

CANCER OF THE UPPER ALIMENTARY TRACT AND LARYNX IN POLAND AND IN POLISH-BORN AMERICANS  

E-Print Network (OSTI)

Summary.-Mortality for cancers of the buccal cavity and pharynx, oesophagus and larynx in Poland in 1959-72 was analysed and compared with cancer incidence regis-tered in the selected regions of Poland, with cancer mortality and incidence in other countries, and with mortality among Polish-born migrants to the U.S.A. The patterns of occurrence of these cancers in Poland appear to be similar to those of other European and American countries, except perhaps for the rather high and still increasing incidence of laryngeal cancer. Among male Polish migrants, however, mortality for these cancers was distinctly higher than either in Poland or among native Americans. This contrast, largest for oesophageal and laryngeal cancer, decreased between 1950 and 1959-61, but only for those aged below 65. Similarity of these shifts with those observed for lung cancer is stressed and explanations are looked for. Factors associated with the studied cancers and outlines for the further studies are discussed briefly. CANCERS of the upper alimentary tract and the larynx have been discussed

J. Staszew-ski

1974-01-01T23:59:59.000Z

369

PROCEEDINGS Open Access Occupational cancer in developed countries  

E-Print Network (OSTI)

Studies of occupational exposures have made major contributions to our understanding of human carcinogenesis. About one third of the factors identified as definite or probable human carcinogens were first investigated in the workplace and these exposures exact a considerable toll on working populations. There are many additional workplace exposures that are suspect carcinogens that require further evaluation to ensure a safe work environment. Information from occupational investigations is also relevant to the general population because many occupational exposures can be found outside the workplace. Much of our understanding about occupational cancer has been obtained from studies largely composed of white men in developed countries. The movement of industry from developed to developing countries underscores the need for future investigations to include more diverse populations. What do we know? Studies of exposures in the workplace have made major contributions to our understanding of human carcinogenesis. The International Agency for Research on Cancer (IARC) Monographs on the Evaluation of

Aaron Blair; Loraine Marrett; Laura Beane Freeman

2009-01-01T23:59:59.000Z

370

HPV & head and neck cancer: a descriptive update  

E-Print Network (OSTI)

similar to tobacco smoke but actually has a greater concentration of the aromatic poly-carbon carcinogens found in cigarette smoke. Fur- thermore, cannabis is usually smoked unfiltered, allowing a greater concentration of toxin unfettered access... implicated in the aetiology of HNSCC, especially a low consumption of fibre and vita- mins in the form of fresh fruit and vegetables [11]. Oral hygiene and the state of dentition have also been linked to an increased risk of developing oro-pharyngeal cancer...

Goon, Peter K C; Stanley, Margaret A; Ebmeyer, Jorg; Steinstraesser, Lars; Upile, Tahwinder; Jerjes, Waseem; Bernal-Sprekelsen, Manuel; Gorner, Martin; Sudhoff, Holger H

2009-10-14T23:59:59.000Z

371

Statistical analysis of end-points in cancer clinical trials  

E-Print Network (OSTI)

of Cancer and Clinical Oncology"), "International Journal of Radiation Oncology Biology Physics", "Journal of 20 Clinical Oncology", and "Radiotherapy and Oncology". Papers were identified from the contents pages and were studied provided they fulfilled... are used. Brief communications in letters and abstracts from meetings were excluded. A decision on the size of the survey was made after the first 20 papers had been studied as a pilot study. Two criteria were used. Firstly a minimum of 50 papers...

Campbell, Ian

372

External Beam Radiotherapy for Colon Cancer: Patterns of Care  

SciTech Connect

Purpose: Despite its common and well characterized use in other gastrointestinal malignancies, little is known about radiotherapy (RT) use in nonmetastatic colon cancer in the United States. To address the paucity of data regarding RT use in colon cancer management, we examined the RT patterns of care in this patient population. Methods and Materials: Patients with nonmetastatic colon cancer, diagnosed between 1988 and 2005, were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate methods were used to identify factors associated with RT use. Results: On univariate analysis, tumor location, age, sex, race, T stage, N stage, and geographic location were each associated with differences in RT use (all p < 0.01). In general, younger patients, male patients, and patients with more advanced disease were more likely to receive RT. On multivariate analysis, tumor location, age, gender, T and N stage, time of diagnosis and geographic location were significantly associated with RT use (all p < 0.001). Race, however, was not associated with RT use. On multivariate analysis, patients diagnosed in 1988 were 2.5 times more likely to receive RT than those diagnosed in 2005 (p = 0.001). Temporal changes in RT use reflect a responsiveness to evolving evidence related to the therapeutic benefits of adjuvant RT. Conclusions: External beam RT is infrequently used for colon cancer, and its use varies according to patient and tumor characteristics. RT use has declined markedly since the late 1980s; however, it continues to be used for nonmetastatic disease in a highly individualized manner.

Dunn, Emily F., E-mail: dunn@humonc.wisc.ed [Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI (United States); Kozak, Kevin R. [Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI (United States); Moody, John S. [Division of Radiation Oncology, Moses Cone Regional Cancer Center, Greensboro, NC (United States)

2010-04-15T23:59:59.000Z

373

Role of Adjuvant Chemoradiotherapy for Resected Extrahepatic Biliary Tract Cancer  

SciTech Connect

Purpose: To evaluate the effect of adjuvant chemoradiotherapy (CRT) on locoregional control (LRC), disease-free survival (DFS), and overall survival (OS) for patients with extrahepatic biliary tract cancer treated with curative resection. Methods and Materials: The study involved 168 patients with extrahepatic biliary tract cancer undergoing curative resection between August 2001 and April 2009. Of the 168 patients, 115 received adjuvant CRT (CRT group) and 53 did not (no-CRT group). Gender, age, tumor size, histologic differentiation, pre- and postoperative carbohydrate antigen 19-9 level, resection margin, vascular invasion, perineural invasion, T stage, N stage, overall stage, and the use of adjuvant CRT were analyzed to identify the prognostic factors associated with LRC, DFS, and OS. Results: For all patients, the 5-year LRC, DFS, and OS rate was 54.8%, 30.6%, and 33.9%, respectively. On univariate analysis, the 5-year LRC, DFS, and OS rates in the CRT group were significantly better than those in the no-CRT group (58.5% vs. 44.4%, p = .007; 32.1% vs. 26.1%, p = .041; 36.5% vs. 28.2%, p = .049, respectively). Multivariate analysis revealed that adjuvant CRT was a significant independent prognostic factor for LRC, DFS, and OS (p < .05). Conclusion: Our results have suggested that adjuvant CRT helps achieve LRC and, consequently, improves DFS and OS in patients with extrahepatic biliary tract cancer.

Kim, Tae Hyun; Han, Sung-Sik; Park, Sang-Jae, E-mail: k2onco@ncc.re.kr; Lee, Woo Jin; Woo, Sang Myung; Moon, Sung Ho; Yoo, Tae; Kim, Sang Soo; Kim, Seong Hoon; Hong, Eun Kyung; Kim, Dae Yong; Park, Joong-Won

2011-12-01T23:59:59.000Z

374

Low dose diagnostic radiation exposure and cancer risk in Trp53+/- mice  

NLE Websites -- All DOE Office Websites (Extended Search)

diagnostic radiation exposure and cancer risk in Trp53+/- mice diagnostic radiation exposure and cancer risk in Trp53+/- mice K Taylor, N Phan, ME Cybulski, L Laframboise, DR Boreham Department of Medical Physics and Applied Radiation Sciences, McMaster University, 1280 Main Street West, Hamilton ON L8S 4K1 The cancer risk associated with exposure to low doses of ionizing radiation has traditionally been extrapolated from effects observed at high doses and high dose rates using a linear no threshold model. Based on this approach, it has been postulated that human exposure to medical imaging involving low doses of x-rays and gamma rays increase an individual's risk of developing cancer throughout their lifetime. Conversely, there is evidence that low doses of gamma radiation increase the latency period of cancer depending upon genotype, cancer type, and the magnitude of

375

Supporting clinical processes with semantic web technologies: a case in breast cancer treatment  

Science Conference Proceedings (OSTI)

Breast cancer surgery is carried out almost entirely manually and there is an obvious risk of human error due to temporary or occasional lack of staff experience (substitutions, sick leaves and other reasons). Another aspect is that the successful ... Keywords: OWL, SOA, automated decision making, breast cancer, cancer treatment, e-healthcare, electronic healthcare, electronic healthcare records, electronic medical records, monitoring, ontologies, ontology web language, patient safety, prognostic factors, semantic web, service-oriented architecture

Ainhoa Serna Nocedal; Jon Kepa Gerrikagoitia; Iker Huerga

2010-09-01T23:59:59.000Z

376

Breast cancer risk and environmental exposures. Environ Health Perspect 105:891–896  

E-Print Network (OSTI)

Although environmental contaminants have potential to affect breast cancer risk, explicit environmental links to this disease are limited. The most well-defined environmental risk factors are radiation exposure and alcohol ingestion. Diet is clearly related to the increased incidence of breast cancer in developed countries, but its precise role is not yet established. Recent studies have implicated exposure to organochlorines including DDT as a risk factor for breast cancer in

Mary S. Wolff; Ainsley Weston

1997-01-01T23:59:59.000Z

377

Risk Factors Associated With Secondary Sarcomas in Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study  

Science Conference Proceedings (OSTI)

Purpose: Childhood cancer survivors have an increased risk of secondary sarcomas. To better identify those at risk, the relationship between therapeutic dose of chemotherapy and radiation and secondary sarcoma should be quantified. Methods and Materials: We conducted a nested case-control study of secondary sarcomas (105 cases, 422 matched controls) in a cohort of 14,372 childhood cancer survivors. Radiation dose at the second malignant neoplasm (SMN) site and use of chemotherapy were estimated from detailed review of medical records. Odds ratios (ORs) and 95% confidence intervals were estimated by conditional logistic regression. Excess odds ratio (EOR) was modeled as a function of radiation dose, chemotherapy, and host factors. Results: Sarcomas occurred a median of 11.8 years (range, 5.3-31.3 years) from original diagnosis. Any exposure to radiation was associated with increased risk of secondary sarcoma (OR = 4.1, 95% CI = 1.8-9.5). A dose-response relation was observed, with elevated risks at doses between 10 and 29.9 Gy (OR = 15.6, 95% CI = 4.5-53.9), 30-49.9 Gy (OR = 16.0, 95% CI 3.8-67.8) and >50 Gy (OR = 114.1, 95% CI 13.5-964.8). Anthracycline exposure was associated with sarcoma risk (OR = 3.5, 95% CI = 1.6-7.7) adjusting for radiation dose, other chemotherapy, and primary cancer. Adjusting for treatment, survivors with a first diagnosis of Hodgkin lymphoma (OR = 10.7, 95% CI = 3.1-37.4) or primary sarcoma (OR = 8.4, 95% CI = 3.2-22.3) were more likely to develop a sarcoma. Conclusions: Of the risk factors evaluated, radiation exposure was the most important for secondary sarcoma development in childhood cancer survivors; anthracycline chemotherapy exposure was also associated with increased risk.

Henderson, Tara O., E-mail: thenderson@peds.bsd.uchicago.edu [University of Chicago, Chicago, IL (United States); Rajaraman, Preetha [National Cancer Institute, Bethesda, MD (United States)] [National Cancer Institute, Bethesda, MD (United States); Stovall, Marilyn [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States)] [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States); Constine, Louis S. [University of Rochester, Rochester, NY (United States)] [University of Rochester, Rochester, NY (United States); Olive, Aliza [Drexel University, Philadelphia, PA (United States)] [Drexel University, Philadelphia, PA (United States); Smith, Susan A. [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States)] [M.D. Anderson Cancer Center, University of Texas, Houston, TX (United States); Mertens, Ann [Emory University, Atlanta, GA (United States)] [Emory University, Atlanta, GA (United States); Meadows, Anna [Children's Hospital of Philadelphia, Philadelphia, PA (United States)] [Children's Hospital of Philadelphia, Philadelphia, PA (United States); Neglia, Joseph P. [University of Minnesota, Minneapolis, MN (United States)] [University of Minnesota, Minneapolis, MN (United States); Hammond, Sue [Nationwide Children's Hospital, Columbus, OH (United States)] [Nationwide Children's Hospital, Columbus, OH (United States); Whitton, John [Fred Hutchinson Cancer Research Center, Seattle, WA (United States)] [Fred Hutchinson Cancer Research Center, Seattle, WA (United States); Inskip, Peter D. [National Cancer Institute, Bethesda, MD (United States)] [National Cancer Institute, Bethesda, MD (United States); Robison, Leslie L. [St. Jude Children's Research Hospital, Memphis, TN (United States)] [St. Jude Children's Research Hospital, Memphis, TN (United States); Diller, Lisa [Dana-Farber Cancer Institute/Children's Hospital Cancer Center, Boston, MA (United States)] [Dana-Farber Cancer Institute/Children's Hospital Cancer Center, Boston, MA (United States)

2012-09-01T23:59:59.000Z

378

Occurrence of Breast Cancer After Chest Wall Irradiation for Pediatric Cancer, as Detected by a Multimodal Screening Program  

Science Conference Proceedings (OSTI)

Purpose: To assess the occurrence of breast cancer (BC) after exposure to ionizing radiation for pediatric cancer, by means of a multimodal screening program. Patients and Methods: We identified 86 patients who had received chest wall radiation therapy for pediatric cancer. Clinical breast examination (CBE), ultrasound (US), and mammography (MX) were performed yearly. Magnetic resonance imaging (MRI) was added as of October 2007. We calculated the risk of developing BC by radiation therapy dose, patient age, and menarche before or after primary treatment. Results: Eleven women developed a BC from July 2002-February 2010. The sensitivity of the screening methods was 36% for CBE, 73% for MX, 55% for US, and 100% for MRI; the specificity was 91%, 99%, 95%, and 80% for CBE, MX, US, and MRI, respectively. The annual BC detection rate was 2.9%. The median age at BC diagnosis was 33 years. Although age had no influence, menarche before as opposed to after radiation therapy correlated significantly with BC (P=.027): the annual BC detection rate in the former subgroup was 5.3%. Conclusions: Mammography proved more sensitive and specific in our cohort of young women than CBE or US. Magnetic resonance imaging proved 100% sensitive (but this preliminary finding needs to be confirmed). Our cohort of patients carries a 10-fold BC risk at an age more than 20 years younger than in the general population.

Terenziani, Monica [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Casalini, Patrizia [Molecular Biology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Molecular Biology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Scaperrotta, Gianfranco; Gandola, Lorenza; Trecate, Giovanna [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Catania, Serena; Cefalo, Graziella [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Conti, Alberto [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Massimino, Maura; Meazza, Cristina; Podda, Marta; Spreafico, Filippo [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Suman, Laura [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Gennaro, Massimiliano, E-mail: gennaromassimiliano@istitutotumori.mi.it [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)

2013-01-01T23:59:59.000Z

379

Development of the M. D. Anderson Cancer Center Gynecologic Applicators for the Treatment of Cervical Cancer: Historical Analysis  

Science Conference Proceedings (OSTI)

Purpose: To provide historical background on the development and initial studies of the gynecological (gyn) applicators developed by Dr. Gilbert H. Fletcher, a radiation oncologist and chairperson from 1948 to 1981 of the department at the M.D. Anderson Hospital (MDAH) for Cancer Research in Houston, TX, and to acknowledge the previously unrecognized contribution that Dr. Leonard G. Grimmett, a radiation physicist and chairperson from 1949 to 1951 of the physics department at MDAH, made to the development of the gynecological applicators. Methods and Materials: We reviewed archival materials from the Historical Resource Center and from the Department of Radiation Physics at University of Texas M. D. Anderson Cancer Center, as well as contemporary published papers, to trace the history of the applicators. Conclusions: Dr. Fletcher's work was influenced by the work on gynecologic applicators in the 1940s in Europe, especially work done at the Royal Cancer Hospital in London. Those efforts influenced not only Dr. Fletcher's approach to the design of the applicators but also the methods used to perform in vivo measurements and determine the dose distribution. Much of the initial development of the dosimetry techniques and measurements at MDAH were carried out by Dr. Grimmett.

Yordy, John S., E-mail: john.yordy@utsouthwestern.edu [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas (United States); Almond, Peter R. [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Delclos, Luis [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

2012-03-15T23:59:59.000Z

380

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents (OSTI)

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2008-09-30T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Analysis of 15 years of skin cancer in central Iran (Yazd)  

E-Print Network (OSTI)

evaluation in center of Iran. Pejoohesh in medical scienceskin cancer in central Iran (Yazd) Mohammad Taghi NoorbalaScience University of Yazd, Iran. mtnoorbala@gmail.com

Noorbala, Mohammad Taghi; Kafaie, P

2007-01-01T23:59:59.000Z

382

Computational methods for analyzing and detecting genomic structural variation : applications to cancer  

E-Print Network (OSTI)

Accurate whole human genome sequencing using reversibleson, S. , 2008: Rapid genome sequencing with short universalalterations in cancer. In Genome Sequencing Technology and

Bashir, Ali

2009-01-01T23:59:59.000Z

383

Incidence of non-lung solid cancers in Czech uranium miners: A case-cohort study  

Science Conference Proceedings (OSTI)

Objectives: Uranium miners are chronically exposed to radon and its progeny, which are known to cause lung cancer and may be associated with leukemia. This study was undertaken to evaluate risk of non-lung solid cancers among uranium miners in Pribram region, Czech Republic. Methods: A retrospective stratified case-cohort study in a cohort of 22,816 underground miners who were employed between 1949 and 1975. All incident non-lung solid cancers were ascertained among miners who worked underground for at least 12 months (n=1020). A subcohort of 1707 subjects was randomly drawn from the same population by random sampling stratified on age. The follow-up period lasted from 1977 to 1996. Results: Relative risks comparing 180 WLM (90th percentile) of cumulative lifetime radon exposure to 3 WLM (10th percentile) were 0.88 for all non-lung solid cancers combined (95% CI 0.73-1.04, n=1020), 0.87 for all digestive cancers (95% CI 0.69-1.09, n=561), 2.39 for gallbladder cancer (95% CI 0.52-10.98, n=13), 0.79 for larynx cancer (95% CI 0.38-1.64, n=62), 2.92 for malignant melanoma (95% CI 0.91-9.42, n=23), 0.84 for bladder cancer (95% CI 0.43-1.65, n=73), and 1.13 for kidney cancer (95% CI 0.62-2.04, n=66). No cancer type was significantly associated with radon exposure; only malignant melanoma and gallbladder cancer showed elevated but non-significant association with radon. Conclusions: Radon was not significantly associated with incidence of any cancer of interest, although a positive association of radon with malignant melanoma and gallbladder cancer cannot be entirely ruled out. - Research highlights: {yields} Uranium miners are chronically exposed to radon. {yields} We evaluate risk of non-lung solid cancers among uranium miners. {yields} No cancer type was significantly associated with radon exposure. {yields} Malignant melanoma and gallbladder cancer showed non-significant elevated risk.

Kulich, M., E-mail: kulich@karlin.mff.cuni.cz [Department of Statistics, Faculty of Mathematics and Physics, Charles University, Sokolovska 83, CZ-186 75 Praha 8 (Czech Republic); Rericha, V. [Regional Hospital Pribram (Czech Republic)] [Regional Hospital Pribram (Czech Republic); Rericha, R. [Center of Epidemiological Studies, Pribram (Czech Republic)] [Center of Epidemiological Studies, Pribram (Czech Republic); Shore, D.L. [Westat, Inc., Durham, NC (United States)] [Westat, Inc., Durham, NC (United States); Sandler, D.P. [Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC (United States)] [Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC (United States)

2011-04-15T23:59:59.000Z

384

BSA 09-12 & 13-11: Radiolabeled Vorozole for Breast Cancer ...  

BSA 09-12 & 13-11: Radiolabeled Vorozole for Breast Cancer Monitoring. ... Brookhaven National Laboratory conducts research in the physical, ...

385

The improvement of cancer management by the application of the currently available knowledge.  

E-Print Network (OSTI)

??I have been intensively involved in the research on the application of currently available knowledge for the improvement of cancer care. This research covers the… (more)

Barton, Michael

2008-01-01T23:59:59.000Z

386

Carotenoids & Retinoids; Molecular Aspects and Health IssuesChapter 18 Lycopene and Prostate Cancer  

Science Conference Proceedings (OSTI)

Carotenoids & Retinoids; Molecular Aspects and Health Issues Chapter 18 Lycopene and Prostate Cancer Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press   Downloadable pdf...

387

Low dose diagnostic radiation exposure and cancer risk in Trp53...  

NLE Websites -- All DOE Office Websites (Extended Search)

University Abstract The cancer risk associated with exposure to low doses of ionizing radiation has traditionally been extrapolated from effects observed at high doses and high...

388

The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort  

E-Print Network (OSTI)

Study cohort. Breast Cancer Research 2011 13:R37. SubmitLee et al. Breast Cancer Research 2011, 13:R37 http://Lee et al. Breast Cancer Research 2011, 13:R37 http://

2011-01-01T23:59:59.000Z

389

Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort  

E-Print Network (OSTI)

Teachers Study cohort Breast Cancer Research 2010, 12:R35SG, Ma et al. Breast Cancer Research 2010, 12:R35 http://car- Ma et al. Breast Cancer Research 2010, 12:R35 http://

2010-01-01T23:59:59.000Z

390

IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer  

E-Print Network (OSTI)

Experimental & Clinical Cancer Research 2013, 32:97 http://Experimental & Clinical Cancer Research 2013 32:97. SubmitExperimental & Clinical Cancer Research 2013, 32:97 http://

2013-01-01T23:59:59.000Z

391

The role and regulation of Flice-Like Inhibitory Protein (FLIP) in cisplatin resistance in human ovarian cancer cells in vitro .  

E-Print Network (OSTI)

??Human ovarian cancer is the most lethal gynecological malignancy. Although cisplatin (CDDP) and paclitaxel are the first-line chemotherapeutic agents for ovarian cancer, chemoresistance is a… (more)

Abedini, Mohammad Reza

2008-01-01T23:59:59.000Z

392

Development of in vivo Raman spectroscopy for the diagnosis of breast cancer and intra-operative margin assessment  

E-Print Network (OSTI)

Breast cancer is the most commonly diagnosed cancer among women in the United States. It is the most common cause of death in women ages 45-55. Optical techniques can potentially play a diagnostic role in several aspects ...

Haka, Abigail S

2005-01-01T23:59:59.000Z

393

Kinase Expression and Chromosomal Rearrangements in Papillary Thyroid Cancer Tissues: Investigations at the Molecular and Microscopic Levels  

E-Print Network (OSTI)

D. Thyroid cancer after Chernobyl. Nature 1992; 359: 21-22.LN. Thyroid cancer after Chernobyl. Nature 5. Nikiforov YE.of children after the Chernobyl reactor accident. Int J

Weier, Heinz-Ulrich

2010-01-01T23:59:59.000Z

394

Effect of Statins and Anticoagulants on Prostate Cancer Aggressiveness  

SciTech Connect

Purpose: Statins and anticoagulants (ACs) have both been associated with a less-aggressive prostate cancer (PCa) and a better outcome after treatment of localized PCa. The results of these studies might have been confounded because patients might often take both medications. We examined their respective influence on PCa aggressiveness at initial diagnosis. Materials and Methods: We analyzed 381 patients treated with either external beam radiotherapy or brachytherapy for low-risk (n = 152), intermediate-risk (n = 142), or high-risk (n = 87) localized PCa. Univariate and multivariate logistic regression analyses were used to investigate an association between these drug classes and prostate cancer aggressiveness. We tested whether the concomitant use of statins and ACs had a different effect than that of either AC or statin use alone. Results: Of the 381 patients, 172 (45.1%) were taking statins and 141 (37.0%) ACs; 105 patients (27.6%) used both. On univariate analysis, the statin and AC users were associated with the prostate-specific antigen (PSA) level (p = .017) and National Comprehensive Cancer Network risk group (p = .0022). On multivariate analysis, statin use was associated with a PSA level <10 ng/mL (odds ratio, 2.9; 95% confidence interval, 1.3-6.8; p = .012) and a PSA level >20 ng/mL (odds ratio, 0.29; 95% confidence interval, 0.08-0.83; p = .03). The use of ACs was associated with a PSA level >20 ng/mL (odds ratio, 0.13; 95% confidence interval, 0.02-0.59, p = .02). Conclusion: Both AC and statins have an effect on PCa aggressiveness, with statins having a more stringent relationship with the PSA level, highlighting the importance of considering statin use in studies of PCa aggressiveness.

Alizadeh, Moein [Department of Radiation Oncology, Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec (Canada); Sylvestre, Marie-Pierre [Research Center, Department of Statistics, University of Montreal, Montreal, Quebec (Canada); Zilli, Thomas; Van Nguyen, Thu; Guay, Jean-Pierre; Bahary, Jean-Paul [Department of Radiation Oncology, Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec (Canada); Taussky, Daniel, E-mail: daniel.taussky.chum@ssss.gouv.qc.ca [Department of Radiation Oncology, Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec (Canada)

2012-07-15T23:59:59.000Z

395

Generic Planning Target Margin for Rectal Cancer Treatment Setup Variation  

SciTech Connect

Purpose: To calculate the generic planning target margin (GPTM) for patients receiving radiation therapy (RT) for rectal cancer placed in a prone position with a customized cradle for small-bowel exclusion. Methods and Materials: A total of 25 consecutive rectal cancer patients were treated for 25 or 28 fractions in a prone position using a cradle to maximize small bowel exclusion. Treatment planning computed tomography (CT) scans were used to create orthogonally digitally reconstructed radiographs (DRRs) for portal image registration, which were compared with daily portal images from an electronic portal-imaging device (EPID). Translation values needed to align the DRRs and EPIDs were recorded for the superior to inferior (SI), right to left (RL), and anterior to posterior (AP) directions, and used to calculate the GPTM using the four-parameter model. Age, weight, and body mass index were tested compared with the setup variation using a Pearson correlation and a t test for significance. Gender versus setup variation was compared with a t test. Results: A total of 1,723 EPID images were reviewed. The GPTM was 10 mm superior, 8 mm inferior, 7 mm RL and 10 mm AP. Age and gender were unrelated to setup variation. Weight was significantly associated with systematic AP variation (p < 0.05). BMI was significantly associated with systematic SI (p < 0.05) and AP (p < 0.01) variation and random RL variation (p < 0.05). Conclusions: The GPTM for rectal cancer is asymmetric with a maximum of 10 mm in the superior, anterior and posterior dimensions. Body mass index may effect setup variation. Research using advanced treatment planning should include these margins in the planning target volume definition.

Robertson, John M. [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States)], E-mail: jrobertson@beaumont.edu; Campbell, Jonathon P.; Yan Di [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States)

2009-08-01T23:59:59.000Z

396

Does Treatment Duration Affect Outcome After Radiotherapy for Prostate Cancer?  

SciTech Connect

Purpose: The protraction of external beam radiotherapy (RT) time is detrimental in several disease sites. In prostate cancer, the overall treatment time can be considerable, as can the potential for treatment breaks. We evaluated the effect of elapsed treatment time on outcome after RT for prostate cancer. Methods and Materials: Between April 1989 and November 2004, 1,796 men with prostate cancer were treated with RT alone. The nontreatment day ratio (NTDR) was defined as the number of nontreatment days divided by the total elapsed days of RT. This ratio was used to account for the relationship between treatment duration and total RT dose. Men were stratified into low risk (n = 789), intermediate risk (n = 798), and high risk (n = 209) using a single-factor model. Results: The 10-year freedom from biochemical failure (FFBF) rate was 68% for a NTDR <33% vs. 58% for NTDR {>=}33% (p = 0.02; BF was defined as a prostate-specific antigen nadir + 2 ng/mL). In the low-risk group, the 10-year FFBF rate was 82% for NTDR <33% vs. 57% for NTDR {>=}33% (p = 0.0019). The NTDR was independently predictive for FFBF (p = 0.03), in addition to T stage (p = 0.005) and initial prostate-specific antigen level (p < 0.0001) on multivariate analysis, including Gleason score and radiation dose. The NTDR was not a significant predictor of FFBF when examined in the intermediate-risk group, high-risk group, or all risk groups combined. Conclusions: A proportionally longer treatment duration was identified as an adverse factor in low-risk patients. Treatment breaks resulting in a NTDR of {>=}33% (e.g., four or more breaks during a 40-fraction treatment, 5 d/wk) should be avoided.

D'Ambrosio, David J. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Li Tianyu [Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, PA (United States); Horwitz, Eric M. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Chen, David Y.T. [Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Pollack, Alan [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Buyyounouski, Mark K. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States)], E-mail: mark.buyyounouski@fccc.edu

2008-12-01T23:59:59.000Z

397

Prediction of epigenetically regulated genes in breast cancer cell lines  

Science Conference Proceedings (OSTI)

Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation of CpG islands may silence associated genes. Therefore, using high-throughput microarrays to measure CpG island methylation will lead to better understanding of tumor pathobiology and progression, while revealing potentially new biomarkers. We have examined a recently developed high-throughput technology for measuring genome-wide methylation patterns called mTACL. Here, we propose a computational pipeline for integrating gene expression and CpG island methylation profles to identify epigenetically regulated genes for a panel of 45 breast cancer cell lines, which is widely used in the Integrative Cancer Biology Program (ICBP). The pipeline (i) reduces the dimensionality of the methylation data, (ii) associates the reduced methylation data with gene expression data, and (iii) ranks methylation-expression associations according to their epigenetic regulation. Dimensionality reduction is performed in two steps: (i) methylation sites are grouped across the genome to identify regions of interest, and (ii) methylation profles are clustered within each region. Associations between the clustered methylation and the gene expression data sets generate candidate matches within a fxed neighborhood around each gene. Finally, the methylation-expression associations are ranked through a logistic regression, and their significance is quantified through permutation analysis. Our two-step dimensionality reduction compressed 90% of the original data, reducing 137,688 methylation sites to 14,505 clusters. Methylation-expression associations produced 18,312 correspondences, which were used to further analyze epigenetic regulation. Logistic regression was used to identify 58 genes from these correspondences that showed a statistically signifcant negative correlation between methylation profles and gene expression in the panel of breast cancer cell lines. Subnetwork enrichment of these genes has identifed 35 common regulators with 6 or more predicted markers. In addition to identifying epigenetically regulated genes, we show evidence of differentially expressed methylation patterns between the basal and luminal subtypes. Our results indicate that the proposed computational protocol is a viable platform for identifying epigenetically regulated genes. Our protocol has generated a list of predictors including COL1A2, TOP2A, TFF1, and VAV3, genes whose key roles in epigenetic regulation is documented in the literature. Subnetwork enrichment of these predicted markers further suggests that epigenetic regulation of individual genes occurs in a coordinated fashion and through common regulators.

Loss, Leandro A; Sadanandam, Anguraj; Durinck, Steffen; Nautiyal, Shivani; Flaucher, Diane; Carlton, Victoria EH; Moorhead, Martin; Lu, Yontao; Gray, Joe W; Faham, Malek; Spellman, Paul; Parvin, Bahram

2010-05-04T23:59:59.000Z

398

Pro-neural transcription factors as cancer markers  

E-Print Network (OSTI)

://www.biomedcentral.com/1755-8794/1/17 We next sought to test the validity of Ascl1, neurotensin receptor (NTR2) and NTS as cancer markers in clinical prostate material from a distinct cohort of patients by immunohistochemistry (Figure 7A). NTS and Ascl1 were negative... bars above the heatmap. These sam- ples were tested for enrichment of malignant tissue types (Table 3). Malignant tissue samples enriching proneural signature sample groups are highlighted as coloured bars at the top of the heatmap. DDC NTS POU4F1 ASCL...

Vias, Maria; Massie, Charles E; East, Philip; Scott, Helen; Warren, Anne; Zhou, Zongxiang; Nikitin, Alexander Yu; Neal, David E; Mills, Ian G

2008-05-19T23:59:59.000Z

399

MicroRNA expression in canine mammary cancer  

E-Print Network (OSTI)

MicroRNAs (miRNAs) play a vital role in differentiation, proliferation and tumorigenesis by binding to messenger RNAs (mRNA) and inhibiting translation. To initiate an investigation into the identification of miRNAs in the domestic dog, an emerging model for human disease, a comparison of the human and canine genetic databases was conducted. The bioinformatics work revealed significant conservation of miRNA genes between the two species. Proof of principle experiments, including serial dilutions and sequencing, were performed to verify that primers made to amplify human mature miRNAs can be used to amplify canine miRNAs, providing that the mature sequences are conserved. TaqMan® Real-time RT-PCR, a sensitive and specific method, was used to isolate the first miRNA mature products from canine tissues. The expression levels of miR-17-3p, miR-17-5p, miR-18, miR-19a, miR-19b, miR-20, and miR-92 were evaluated in five canine tissues (heart, lung, brain, kidney, and liver). Because miRNAs have been found to act as both tumor suppressors and oncogenes in several different cancers, expression patterns of ten miRNAs (miR-15a, miR-16, miR-17-5p, miR-21, miR-29b, miR-125b, miR-145, miR-155, miR-181b, let-7f) known to be associated with human breast cancer were compared between malignant canine mammary tumors (n=6) and normal canine mammary tissue (n=10). Resulting data revealed miR-29b and miR-21 to have a statistically significant (p<0.05) up-regulation in cancerous samples. Overall expression patterns showed nine of the ten miRNAs follow the same pattern of expression in the domestic dog as the human, while the miR-145 expression does not show a difference between the normal and cancerous samples.

Boggs, Rene' Michelle

2008-05-01T23:59:59.000Z

400

Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer  

Science Conference Proceedings (OSTI)

Purpose: Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chemotherapy (CChT) and PBT (CChT/PBT) at MD Anderson Cancer Center. Methods and Materials: This is an analysis of 62 esophageal cancer patients enrolled on a prospective study evaluating normal tissue toxicity from CChT/PBT from 2006 to 2010. Patients were treated with passive scattering PBT with two- or three-field beam arrangement using 180 to 250 MV protons. We used the Kaplan-Meier method to assess time-to-event outcomes and compared the distributions between groups using the log-rank test. Results: The median follow-up time was 20.1 months for survivors. The median age was 68 years (range, 38-86). Most patients were males (82%) who had adenocarcinomas (76%) and Stage II-III disease (84%). The median radiation dose was 50.4 Gy (RBE [relative biologic equivalence]) (range, 36-57.6). The most common grade 2 to 3 acute toxicities from CChT/PBT were esophagitis (46.8%), fatigue (43.6%), nausea (33.9%), anorexia (30.1%), and radiation dermatitis (16.1%). There were two cases of grade 2 and 3 radiation pneumonitis and two cases of grade 5 toxicities. A total of 29 patients (46.8%) received preoperative CChT/PBT, with one postoperative death. The pathologic complete response (pCR) rate for the surgical cohort was 28%, and the pCR and near CR rates (0%-1% residual cells) were 50%. While there were significantly fewer local-regional recurrences in the preoperative group (3/29) than in the definitive CChT/PBT group (16/33) (log-rank test, p = 0.005), there were no differences in distant metastatic (DM)-free interval or overall survival (OS) between the two groups. Conclusions: This is the first report of patients treated with PBT/CChT for esophageal cancer. Our data suggest that this modality is associated with a few severe toxicities, but the pathologic response and clinical outcomes are encouraging. Prospective comparison with more traditional approach is warranted.

Lin, Steven H., E-mail: shlin@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Komaki, Ritsuko; Liao Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei, Caimiao [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Myles, Bevan [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Guo Xiaomao [Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai (China); Palmer, Matthew [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Swisher, Stephen G.; Hofstetter, Wayne L. [Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cox, James D. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2012-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

ORIGINAL PAPER A new view of radiation-induced cancer: integrating  

E-Print Network (OSTI)

- induced second malignancies, on Japanese atomic bomb survivors, and on background US cancer incidence and carcin- ogenic agent. As such, it is effective as a treatment for cancer, but can also induce secondary (&) Center for Radiological Research, Columbia University Medical Center, 630 West 168th St., New York, NY

Brenner, David Jonathan

402

Network-based classification of recurrent endometrial cancers using high-throughput DNA methylation data  

Science Conference Proceedings (OSTI)

DNA methylation, a well-studied mechanism of epigenetic regulation, plays important roles in cancer. Increased levels of global DNA methylation is observed in primary solid tumors including endometrial carcinomas and is generally associated with silencing ... Keywords: DNA methylation, Steiner tree, cancer recurrence, classification, protein-protein interaction network, random walk

Jianhua Ruan; Md. Jamiul Jahid; Fei Gu; Chengwei Lei; Yi-Wen Huang; Ya-Ting Hsu; David G. Mutch; Chun-Liang Chen; Nameer B. Kirma; Tim H. Huang

2012-10-01T23:59:59.000Z

403

An integrated algorithm for gene selection and classification applied to microarray data of ovarian cancer  

Science Conference Proceedings (OSTI)

Objective: The type of data in microarray provides unprecedented amount of data. A typical microarray data of ovarian cancer consists of the expressions of tens of thousands of genes on a genomic scale, and there is no systematic procedure to analyze ... Keywords: Gene selection, Genetic algorithm, Microarray data, Ovarian cancer, Particle swarm optimization, Support vector machine

Zne-Jung Lee

2008-01-01T23:59:59.000Z

404

Evaluation of cancer mortality in a cohort of workers exposed to low-level radiation  

SciTech Connect

The purpose of this dissertation was to re-analyze existing data to explore methodologic approaches that may determine whether excess cancer mortality in the ORNL cohort can be explained by time-related factors not previously considered; grouping of cancer outcomes; selection bias due to choice of method selected to incorporate an empirical induction period; or the type of statistical model chosen.

Lea, C.S.

1995-12-01T23:59:59.000Z

405

Markers Combined Inhibin and CA125 Assays in the Detection of Ovarian Cancer  

E-Print Network (OSTI)

Background: The reproductive hormone inhibin has been used as a diagnostic marker of ovarian mucinous and granulosa cell cancers. The aims of this study were to develop a new inhibin immunofluorometric assay (?C IFMA) to replace an inhibin RIA as a diagnostic marker of these ovarian cancers and to assess whether the ?C IFMA in combination with CA125, which detects serous cancers, leads to an improved biochemical diagnosis of all ovarian cancers. Methods: Serum inhibin concentrations were determined in healthy postmenopausal women (n ? 165) and women with ovarian cancers (n ? 154), using an inhibin RIA and an ?C IFMA, which detects inhibin forms containing the ?C subunit as well as the free ?C subunit. Results: The ?C IFMA gave a similar or better discrimination of mucinous (90 % vs 71%) and granulosa cell (100 % vs 100%) cancers compared with the inhibin RIA. Combination of CA125 and ?C IFMA values by canonical variate analysis or by multiROC analysis showed that the percentage of all ovarian cancers detected was significantly increased compared with either CA125 or ?C IFMA alone. Conclusions: The ?C IFMA shows a similar or better specificity compared with the RIA, but with increased sensitivity. In combination with CA125, the ?C IFMA provides an effective dual test for the detection of the majority (90%) of ovarian cancers.

David M. Robertson; Nicholas Cahir; Henry G. Burger; Pamela Mamers; Philip I. Mccloud; Kim Pettersson; Michael Mcguckin

1998-01-01T23:59:59.000Z

406

Utilizing 2-NBDG Fluorescence to Study Hypoxia-Induced Changes in Breast Cancer Glycolysis  

E-Print Network (OSTI)

· 2-NBDG is preferentially taken up in cancer over normal · 2-NBDG can be used to track changes-NBDG to track changes in glycolysis resulting from hypoxia Time after hypoxia OBJECTIVES APPROACH hypoxia study to a panel of human breast cancer cell lines of various receptor status (ER+, ER-, HER2

Ramanujam, Nimmi

407

Journal of Theoretical Biology 249 (2007) 518531 Second cancers after fractionated radiotherapy: Stochastic population  

E-Print Network (OSTI)

-studied carcinogen, followed by long-term monitoring. In addition to putative radiation initiation that produces pre Abstract When ionizing radiation is used in cancer therapy it can induce second cancers in nearby organs into human carcinogenesis, since the therapy involves administering well-characterized doses of a well

Brenner, David Jonathan

408

An optimal tumor marker group-coupled artificial neural network for diagnosis of lung cancer  

Science Conference Proceedings (OSTI)

Background: Epidemiological statistics has shown that there are approximately 1.2 million new cases of lung cancer diagnosed every year and the death rate of these patients is 17.8%. Earlier diagnosis is key to promote the five-year survival rate of ... Keywords: Artificial neural network, Diagnosis, Lung cancer, Tumor marker

Yongjun Wu; Yiming Wu; Jing Wang; Zhen Yan; Lingbo Qu; Bingren Xiang; Yiguo Zhang

2011-09-01T23:59:59.000Z

409

Design and development of stacked patch antenna for breast cancer detection  

Science Conference Proceedings (OSTI)

Breast cancer affects many women, and early detection aids in fast and effective treatment. Mammography, which is currently the most popular method of breast screening, has some limitations, and microwave imaging offers an attractive alternative. The ... Keywords: breast cancer detection, stacked patch antenna, wide slot antenna

N. Mahalakshmi; N. R. Indira; P. Vasikaran

2011-02-01T23:59:59.000Z

410

Fuzzy-probabilistic multi agent system for breast cancer risk assessment and insurance premium assignment  

Science Conference Proceedings (OSTI)

In this paper, we present an agent-based system for distributed risk assessment of breast cancer development employing fuzzy and probabilistic computing. The proposed fuzzy multi agent system consists of multiple fuzzy agents that benefit from fuzzy ... Keywords: Breast cancer, Fuzzy probability, Fuzzy-probabilistic multi agent system, Insurance premium, Uncertainty

Farzaneh Tatari; Mohammad-R. Akbarzadeh-T; Ahmad Sabahi

2012-12-01T23:59:59.000Z

411

Microwave tomography for breast cancer detection on Cell broadband engine processors  

Science Conference Proceedings (OSTI)

Microwave tomography (MT) is a safe screening modality that can be used for breast cancer detection. The technique uses the dielectric property contrasts between different breast tissues at microwave frequencies to determine the existence of abnormalities. ... Keywords: Breast cancer detection, Cell BE processor, Finite-difference time-domain (FDTD), Microwave tomography (MT)

Meilian Xu; Parimala Thulasiraman; Sima Noghanian

2012-09-01T23:59:59.000Z

412

Low-Dose Spiral CT Scans for Early Lung Cancer Detection | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-dose spiral computed tomography (CT) scanning is a noninvasive medical imaging test that has been used for the early detection of lung cancer for over 16 years (Sone et al. 1998; Henschke et.al. 1999). A low-dose spiral chest CT differs from a full-dose conventional chest CT scan primarily in the amount of radiation emitted during CT scans. Chest CT, in general, requires less radiation exposure than other CT procedures because the air-filled tissues of the lungs are not as dense as the tissues of other organs (i.e., less x-ray radiation is needed to penetrate the lung). Radiation dose can be further reduced with lung cancer screening due to the

413

Low Dose Radiation Research Program: The Risk of Cancer Induction Due to  

NLE Websites -- All DOE Office Websites (Extended Search)

November 10-12, 1999, Washington, D.C. November 10-12, 1999, Washington, D.C. The Risk of Cancer Induction Due to Routine Mammographic Screening Featured Project Description David J. Brenner, Steve Marino, and Charles Geard, Center for Radiological Research, Columbia University, 630 West 168th Street, New York Summary: To obtain realistic and credible risk estimates for breast-cancer mortality due to clinical mammographic imaging examinations. Abstract: The aim of this work is to obtain realistic and credible risk estimates for breast-cancer mortality due to clinical mammographic imaging examinations. Given the increasing emphasis on clinical mammographic screening for breast cancer, it is of societal importance to provide realistic risk estimates with realistic confidence bounds for breast cancer

414

The State Cancer Profiles web site and extensions of linked micromap plots and conditioned choropleth map plots  

Science Conference Proceedings (OSTI)

The National Cancer Institute's State Cancer Profiles web site that was launched in mid-April put the power of new graphical tools into the hands of cancer control planners and the public. This paper emphasizes advances in two graphics templates, one ...

Daniel B. Carr; Sue Bell; Linda Pickle; Yuguang Zhang; Yaru Li

2003-05-01T23:59:59.000Z

415

Addressing colorectal cancer disparities: the identification of geographic targets for screening interventions in Miami-Dade County, Florida  

Science Conference Proceedings (OSTI)

This paper describes an analysis of spatial clustering of colorectal cancer (CRC) in Miami-Dade County, Florida. The objective was to identify geographically based targets for colorectal cancer screening interventions for Blacks and Hispanic Whites, ... Keywords: SaTScan, colorectal cancer clusters, public health significance, screening disparities, stage at diagnosis

Recinda Sherman; Kevin Henry; David Lee

2012-11-01T23:59:59.000Z

416

Radiation-Induced Cancers From Modern Radiotherapy Techniques: Intensity-Modulated Radiotherapy Versus Proton Therapy  

Science Conference Proceedings (OSTI)

Purpose: To assess and compare secondary cancer risk resulting from intensity-modulated radiotherapy (IMRT) and proton therapy in patients with prostate and head-and-neck cancer. Methods and Materials: Intensity-modulated radiotherapy and proton therapy in the scattering mode were planned for 5 prostate caner patients and 5 head-and-neck cancer patients. The secondary doses during irradiation were measured using ion chamber and CR-39 detectors for IMRT and proton therapy, respectively. Organ-specific radiation-induced cancer risk was estimated by applying organ equivalent dose to dose distributions. Results: The average secondary doses of proton therapy for prostate cancer patients, measured 20-60cm from the isocenter, ranged from 0.4 mSv/Gy to 0.1 mSv/Gy. The average secondary doses of IMRT for prostate patients, however, ranged between 3 mSv/Gy and 1 mSv/Gy, approximately one order of magnitude higher than for proton therapy. Although the average secondary doses of IMRT were higher than those of proton therapy for head-and-neck cancers, these differences were not significant. Organ equivalent dose calculations showed that, for prostate cancer patients, the risk of secondary cancers in out-of-field organs, such as the stomach, lungs, and thyroid, was at least 5 times higher for IMRT than for proton therapy, whereas the difference was lower for head-and-neck cancer patients. Conclusions: Comparisons of organ-specific organ equivalent dose showed that the estimated secondary cancer risk using scattering mode in proton therapy is either significantly lower than the cases in IMRT treatment or, at least, does not exceed the risk induced by conventional IMRT treatment.

Yoon, Myonggeun, E-mail: mxy131@ncc.re.k [Proton Therapy Center, National Cancer Center, Goyang (Korea, Republic of); Ahn, Sung Hwan; Kim, Jinsung; Shin, Dong Ho; Park, Sung Yong; Lee, Se Byeong; Shin, Kyung Hwan; Cho, Kwan Ho [Proton Therapy Center, National Cancer Center, Goyang (Korea, Republic of)

2010-08-01T23:59:59.000Z

417

Cancer-Associated IDH1 Mutations Produce 2-hydroxyglutarate  

SciTech Connect

Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. These mutations occur at a single amino acid residue of the IDH1 active site, resulting in loss of the enzyme's ability to catalyse conversion of isocitrate to {alpha}-ketoglutarate. However, only a single copy of the gene is mutated in tumours, raising the possibility that the mutations do not result in a simple loss of function. Here we show that cancer-associated IDH1 mutations result in a new ability of the enzyme to catalyse the NADPH-dependent reduction of {alpha}-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). Structural studies demonstrate that when arginine 132 is mutated to histidine, residues in the active site are shifted to produce structural changes consistent with reduced oxidative decarboxylation of isocitrate and acquisition of the ability to convert {alpha}-ketoglutarate to 2HG. Excess accumulation of 2HG has been shown to lead to an elevated risk of malignant brain tumours in patients with inborn errors of 2HG metabolism. Similarly, in human malignant gliomas harbouring IDH1 mutations, we find markedly elevated levels of 2HG. These data demonstrate that the IDH1 mutations result in production of the onco-metabolite 2HG, and indicate that the excess 2HG which accumulates in vivo contributes to the formation and malignant progression of gliomas.

Dang, L.; White, D; Gross, S; Bennett, B; Bittinger, M; Driggers, E; Fantin, V; Jang, H; Jin, S; et al.

2009-01-01T23:59:59.000Z

418

Breast Cancer and Personal Environmental Risk Factors in Marin County --  

NLE Websites -- All DOE Office Websites (Extended Search)

Breast Cancer and Personal Environmental Risk Factors in Marin County -- Breast Cancer and Personal Environmental Risk Factors in Marin County -- Pilot Study Title Breast Cancer and Personal Environmental Risk Factors in Marin County -- Pilot Study Publication Type Report Year of Publication 2003 Authors Erdmann, Christine A., Georgianna Farren, Kimberly Baltzell, Terri Chew, Cynthia Clarkson, Ruth Fleshman, Colin Leary, Mary Mizroch, Fern Orenstein, Marion L. Russell, Virginia Souders-Mason, and Margaret Wrensch Abstract The purpose of the Personal Environmental Risk Factor Study (PERFS) pilot project was to develop methodologies and a questionnaire for a future population-based case-control study to investigate the role of selected environmental exposures in breast cancer development. Identification of etiologically relevant exposures during a period of potential vulnerability proximate to disease onset offers the possibility of clinical disease prevention even when disease initiation may have already occurred many years earlier. Certain personal environmental agents or combinations of agents may influence disease promotion. Therefore, this pilot study focused on exposures that occurred during the ten-year period prior to diagnosis for cases and the last ten years for controls, rather than more historic exposures. For this pilot study, we used a community-based research approach. In our collaborative efforts, community members participated with academic researchers in all phases of the research, including research question identification, study design, development of research tools, development of the human subjects protocol, and report writing. Community member inclusion was based upon the concept that community participation could improve the relevance of scientific studies and ultimate success of the research by encouraging an ongoing dialogue between community members and academic representatives. Early activities of this project focused on the collection of input from the community regarding the possible role of environmental factors in the incidence of breast cancer in Marin County. The intent was to inform the scientists of community concerns, enhance the research team's understanding of the community being studied, and provide interested community members with a better understanding of the strengths and weaknesses of traditional research methods through active participation in the research process. This pilot study identified specific testable hypotheses through review of the literature and consultation with relevant experts and the affected community. Initially, the study was to focus on modifiable personal environmental exposures that are associated with breast tumor promotion and higher socioeconomic status (SES). However, little information was available in the scientific literature regarding the putative mechanism by which some of the suspected environmental factors may act (i.e., initiator vs. promoter). Likewise, little is known about the distribution of personal environmental risk factors by socioeconomic status. Therefore, tumor promotion involvement and association with SES were not very useful as selection criteria, and selection of topics was based primarily on published scientific findings of human studies and community input. This study was approved by the Institutional Review Boards at the University of California at San Francisco (Committee on Human Research) and at the University of California at Berkeley (Committee for the Protection of Human Subjects)

419

Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990  

Science Conference Proceedings (OSTI)

This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation. The follow-up is extended by the 5 years 1986-1990, and analysis includes an additional 10,500 survivors with recently estimated radiation doses. Together these extensions add about 550,000 person-years of follow-up. The cohort analyzed consists of 86,572 subjects, of which about 60% have dose estimates of at least 0.005 Sv. During 1950-1990 there have been 3086 and 4741 cancer deaths for the less than and greater than 0.005 Sv groups, respectively. It is estimated that among these there have been approximately 420 excess cancer deaths during 19509-1990, of which about 85 were due to leukemia, For cancers other than leukemia (solid cancers), about 25% of the excess deaths in 1950-1990 occurred during the last 5 years; for those exposed as children this figure is nearly 50%. For leukemia only about 3% of the excess deaths in 1950-1990 occurred in th last 5 years. Whereas most of the excess for leukemia occurred in the first 15 years after exposure, for solid cancers the pattern of excess risk in apparently more like alife-long elevation of the natural age-specific cancer risk. 29 refs., 8 figs., 19 tabs.

Pierce, D.A.; Shimizu, Y.; Preston, D.L. [Radiation Effects Research Foundation, Hiroshima (Japan)] [and others

1996-07-01T23:59:59.000Z

420

Editorial Introducing Viewpoints — Breast Cancer Research’s new style literature appraisal service  

E-Print Network (OSTI)

Literature awareness is an essential requirement for successful research. Breast Cancer Research has launched a new Viewpoints section, which replaces the Paper Reports section as a means of highlighting important research articles relevant to the biology of breast cancer and bringing them to the attention of the breast cancer community. 160 As publications on breast cancer (ranging from basic science through to results of clinical trials) continue apace, it is essential that those involved in the field are made aware of key developments. To facilitate this, Breast Cancer Research launched a Paper Report service in May 1999. The original format highlighted recent publications specifically relevant to breast cancer in the form of a short report. Each report, which was published on our web site, included a brief description of the research and comments from the reporter. The reports were based on articles selected by the reporter from a broad range of journals covering all areas of science relevant to research in breast cancer. Since the service began, we have published 188 Paper Reports on our web site

Valerie Speirs

2003-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Kilovoltage Imaging Doses in the Radiotherapy of Pediatric Cancer Patients  

Science Conference Proceedings (OSTI)

Purpose: To investigate doses induced by kilovoltage cone-beam computed tomography (kVCBCT) to pediatric cancer patients undergoing radiotherapy, as well as strategies for dose reduction. Methods and Materials: An EGS4 Monte Carlo code was used to calculate three-dimensional dose deposition due to kVCBCT on 4 pediatric cancer patients. Absorbed doses to various organs were analyzed for both half-fan and full-fan modes. Clinical conditions, such as distance from organ at risk (OAR) to CBCT field border, kV peak energy, and testicular shielding, were studied. Results: The mean doses induced by one CBCT scan operated at 125 kV in half-fan mode to testes, liver, kidneys, femoral heads, spinal cord, brain, eyes, lens, and optical nerves were 2.9, 4.7, 7.7, 10.5, 8.8, 7.6, 7.7, 7.8, and 7.2 cGy, respectively. Increasing the distances from OARs to CBCT field border greatly reduced the doses to OARs, ranging from 33% reduction for spinal cord to 2300% reduction for testes. As photon beam energy increased from 60 to 125 kV, the dose increase due to kVCBCT ranged from 170% for lens to 460% for brain and spinal cord. A testicular shielding made of 1-cm cerrobend could reduce CBCT doses down to 31%, 51%, 68%, and 82%, respectively, for 60, 80, 100, and 125 kV when the testes lay within the CBCT field. Conclusions: Generally speaking, kVCBCT deposits much larger doses to critical structures in children than in adults, usually by a factor of 2 to 3. Increasing the distances from OARs to CBCT field border greatly reduces doses to OARs. Depending on OARs, kVCBCT-induced doses increase linearly or exponentially with photon beam energy. Testicular shielding works more efficiently at lower kV energies. On the basis of our study, it is essential to choose an appropriate scanning protocol when kVCBCT is applied to pediatric cancer patients routinely.

Deng Jun, E-mail: jun.deng@yale.edu [Department of Therapeutic Radiology, Yale University, New Haven, CT (United States); Chen Zhe; Roberts, Kenneth B.; Nath, Ravinder [Department of Therapeutic Radiology, Yale University, New Haven, CT (United States)

2012-04-01T23:59:59.000Z

422

Role and expression of FRS2 and FRS3 in prostate cancer.  

E-Print Network (OSTI)

by quantitative real time PCR in a panel of archival clinical prostate cancers using methods previously developed in our group [25]. Benign (n = 5), Grade 3 (n = 4), Grade 4 (n = 6) and Grade 5 (n = 9) tumors each derived from separate individual patients were... accelerates tumorigenicity of prostate epithelial cells. Cancer Research 1997, 57:5369-5378. 8. Freeman KW, Gangula RD, Welm BE, Ozen M, Foster BA, Rosen JM, Ittmann M, Greenberg NM, Spencer DM: Conditional activation of Valencia et al. BMC Cancer 2011, 11...

Valencia, Tania; Joseph, Ajay; Kachroo, Naveen; Darby, Steve; Meakin, Susan; Gnanapragasam, Vincent J

2011-11-11T23:59:59.000Z

423

DOE/EA-0965 ENVIRONMENTAL ASSESSMENT CANCER RESEARCH CENTER  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

65 65 ENVIRONMENTAL ASSESSMENT CANCER RESEARCH CENTER INDIANA UNIVERSITY SCHOOL OF MEDICINE PREPARED BY U.S. DEPARTMENT O F ENERGY, CHICAGO FIELD OFFICE PROGRAMS AND FACILITIES MANAGEMENT D I V I S I O N AUGUST 1994 DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsi- bility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Refer- ence herein to any specific commercial product. process, or service by trade name, trademark,

424

Laser-induced differential normalized fluorescence method for cancer diagnosis  

SciTech Connect

An apparatus and method for cancer diagnosis are disclosed. The diagnostic method includes the steps of irradiating a tissue sample with monochromatic excitation light, producing a laser-induced fluorescence spectrum from emission radiation generated by interaction of the excitation light with the tissue sample, and dividing the intensity at each wavelength of the laser-induced fluorescence spectrum by the integrated area under the laser-induced fluorescence spectrum to produce a normalized spectrum. A mathematical difference between the normalized spectrum and an average value of a reference set of normalized spectra which correspond to normal tissues is calculated, which provides for amplifying small changes in weak signals from malignant tissues for improved analysis. The calculated differential normalized spectrum is correlated to a specific condition of a tissue sample.

Vo-Dinh, Tuan (Knoxville, TN); Panjehpour, Masoud (Knoxville, TN); Overholt, Bergein F. (Knoxville, TN)

1996-01-01T23:59:59.000Z

425

Genetically engineered multivalent single chain antibody constructs for cancer therapy  

SciTech Connect

Current therapeutic approaches against the advanced stages of human solid tumors are palliative rather than curative. Many modalities, including, surgery, radiation, and chemotherapy, either alone or in combination have met with only modest success for advanced metastatic cancers. Radioimmunotherapy (RIT) combines the specificity of monoclonal antibodies with cytotxic effects of radioisotopes. It is the ?smart? way of delivering radiation to the known and occult metastatic cancer cells and is independent of drug toxicity and/or hormone resistance. The tumor associated glycoprotein-72 (TAG-72) containing the unique disaccharide sialyl-Tn, is highly expressed in majority of adenocarcinomas, including carcinomas of the prostate, breast, ovaries, pancreas and colon (80-90%) compared to undetectable expression in normal tissues. Monoclonal antibody CC49, reactive with TAG-72, after conjugation to potent gamma- and beta-emitting radionuclides, has been useful in selective systemic radiolocalization of disease and therapy of primary and metastatic tumor sites. However, limited therapeutic responses were observed in patients. Limited success of antibody based delivery of radioisotopes can be attributed to several factors including undesirable pharmacokinetics, poor tumor uptake and high immunogenicity of intact antibodies (IgGs). The primary factors contributing towards the failure of RIT include: 1) longer serum half-lives of the intact IgG molecules resulting in the radiotoxicity, 2) generation of human antibodies against murine antibodies (HAMA) that limits the frequency of dose administration, 3) poor diffusion rates of intact IgG due to the large size and 4) high interstitial fluid pressures (IFP) encountered in solid tumors. The major goal of our multidisciplinary project was to develop specific novel radiopharmaceuticals, with desired pharmacokinetics, for the diagnosis and therapy of solid tumors. To overcome the low uptake of radioactivity by tumors and to increase its tumor: normal tissue ratio for improved therapeutic index, we engineered a variety antibody constructs. These constructs were evaluated using novel approaches like special radionuclides, pretargeting and optimization. Due to the smaller size, the engineered antibody molecules should penetrate better throughout a tumor mass, with less dose heterogeneity, than is the case with intact IgG. Multivalent scFvs with an appropriate radionuclide, therefore, hold promising prospects for cancer therapy and clinical imaging in MAb-based radiopharmaceuticals. In addition, the human anti-mouse antibodies (HAMA) responses in patients against antibody-based therapy are usually directed against the immunoglobulin constant regions; however, anti-idiotypic responses can also be detected. The HAMA responses reduce the efficacy of treatment by removing the circulating antibody molecules, fragments, and possibly scFvs by altering the pharmacokinetic properties of the antibody. HAMA responses against divalent IgG, divalent Ig fragments, and possibly multimeric scFvs could cause immune complex formation with hypersensitivity or allergic reactions that could be harmful to patients. The use of small molecules, such as scFvs (monomeric as well as multimeric), with their shorter biological half-lives and the lack of the constant regions and humanized variable (binding regions) performed in our studies should reduce the development of HAMA. The generation of humanized and fully human scFvs should further reduce the development of HAMA. Specific accomplishments on the project are the production of large amounts of recombinant antibodies as they are required in large amounts for cancer diagnosis and therapy. A variety of single-chain Fv (scFv) constructs were engineered for the desired pharmacokinetic properties. Tetrameric and dimeric scFvs showed a two-fold advantage: (1) there was a considerable gain in avidity as compared to smaller fragments, and (2) the biological half-life was more compatible with RIT and RIS requirements. For RIT, delivery for sc(Fv)2 and [sc(Fv)2]2 in a fr

Surinder Batra, Ph.D.

2006-02-27T23:59:59.000Z

426

MORPHOMETRIC SUBTYPING FOR A PANEL OF BREAST CANCER CELL LINES  

Science Conference Proceedings (OSTI)

A panel of cell lines of diverse molecular background offers an improved model system for high-content screening, comparative analysis, and cell systems biology. A computational pipeline has been developed to collect images from cell-based assays, segment individual cells and colonies, represent segmented objects in a multidimensional space, and cluster them for identifying distinct subpopulations. While each segmentation strategy can vary for different imaging assays, representation and subpopulation analysis share a common thread. Application of this pipeline to a library of 41 breast cancer cell lines is demonstrated. These cell lines are grown in 2D and imaged through immunofluorescence microscopy. Subpopulations in this panel are identified and shown to correlate with previous subtyping literature that was derived from transcript data.

Han, Ju; Chang, Hang; Fontenay, Gerald; Wang, Nicholas J.; Gray, Joe W.; Parvin, Bahram

2009-05-08T23:59:59.000Z

427

Thyroid nodularity and cancer among Chernobyl cleanup workers from Estonia  

SciTech Connect

Thyroid examinations, including palpation, ultrasound and, selectively, fine-needle aspiration biopsy, were conducted on nearly 2,000 Chernobyl cleanup workers from Estonia to evaluate the occurrence of thyroid cancer and nodular thyroid disease among men with protracted exposure to ionizing radiation. The examinations were conducted in four cities in Estonia during March-April 1995, 9 years after the reactor accident. The study population was selected from a predefined cohort of 4,833 cleanup workers from Estonia under surveillance for cancer incidence. These men had been sent to Chernobyl between 1986 and 1991 to entomb the damaged reactor, remove radioactive debris and perform related cleanup activities. A total of 2,997 men were invited for thyroid screening and 1,984 (66%) were examined. Estimates of radiation dose from external sources were obtained from military or other institutional records, and details about service dates and types of work performed while at Chernobyl were obtained from a self-administered questionnaire. Blood samples were collected for assay of chromosomal translocations in circulating lymphocytes and loss of expression of the glycophorin A (GPA) gene in erythrocytes. The primary outcome measure was the presence or absence of thyroid nodules as determined by the ultrasound examination. Of the screened workers, 1,247 (63%) were sent to Chernobyl in 1986, including 603 (30%) sent in April or May, soon after the accident. Workers served at Chernobyl for an average of 3 months. The average age was 32 years at the time of arrival at Chernobyl and 40 years at the time of thyroid examination. The mean documented radiation dose from external sources was 10.8 cGy. Biological indicators of exposure showed low correlations with documented dose, but did not indicate that the mean dose for the population was higher than the average documented dose. 47 refs., 1 fig., 9 tabs.

Inskip, P.D.; Boice, J.D. Jr. [National Cancer Inst., Rockville, MD (United States); Tekkel, M. [Univ. of New Mexico, Albuquerque, NM (United States)] [and others

1997-02-01T23:59:59.000Z

428

Expression of hPNAS-4 Radiosensitizes Lewis Lung Cancer  

SciTech Connect

Purpose: This study aimed to transfer the hPNAS-4 gene, a novel apoptosis-related human gene, into Lewis lung cancer (LL2) and observe its radiosensitive effect on radiation therapy in vitro and in vivo. Methods and Materials: The hPNAS-4 gene was transfected into LL2 cells, and its expression was detected via western blot. Colony formation assay and flow cytometry were used to detect the growth and apoptosis of cells treated with irradiation/PNAS-4 in vitro. The hPNAS-4 gene was transferred into LL2-bearing mice through tail vein injection of the liposome/gene complex. The tumor volumes were recorded after radiation therapy. Proliferating cell nuclear antigen (PCNA) immunohistochemistry staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were performed to detect the tumor cell growth and apoptosis in vivo. Results: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue, and its overexpressions were confirmed via western blot analysis. Compared with the control, empty plasmid, hPNAS-4, radiation, and empty plasmid plus radiation groups, the hPNAS-4 plus radiation group more significantly inhibited growth and enhanced apoptosis of LL2 cells in vitro and in vivo (P<.05). Conclusions: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue and was expressed in both LL2 cell and tumor tissue. The hPNAS-4 gene therapy significantly enhanced growth inhibition and apoptosis of LL2 tumor cells by radiation therapy in vitro and in vivo. Therefore, it may be a potential radiosensitive treatment of radiation therapy for lung cancer.

Zeng Hui [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Yuan Zhu [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Zhu Hong [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Lei; Shi Huashan [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Wang Zi; Fan Yu; Deng Qian; Zeng Jianshuang; He Yinbo [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Xiao Jianghong [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Zhiping, E-mail: lizhiping620312@yahoo.com.cn [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)

2012-11-15T23:59:59.000Z

429

The Effects of Radiation on Development of Prostate Cancer and Prostatic  

NLE Websites -- All DOE Office Websites (Extended Search)

Effects of Radiation on Development of Prostate Cancer and Prostatic Effects of Radiation on Development of Prostate Cancer and Prostatic Hyperplasia in Canine Model Gayle Woloschak Northwestern University Abstract Purpose/Objective(s): There have been few studies analyzing radiation-induced prostate cancer in humans or animals. Our research attempts to fill this void by determining the effects of cobalt-60 gamma radiation on the incidence of prostate cancer and prostatic hyperplasia in a large cohort of beagle dogs. Material/Methods: The subjects for the experiment were beagle dogs, which were chosen due to physiologic and anatomic similarities to humans (Thompson, 1989). We retrospectively analyzed data from historic irradiation experiments conducted at Argonne National Laboratory on 347 beagles. The cobalt-60 cohort consisted of 268 dogs, which received whole

430

Cost-Effectiveness of a Mailed Educational Reminder to Increase Colorectal Cancer Screening  

E-Print Network (OSTI)

controlled trial of faecal-occult-blood screening forcancer with faecal-occult-blood test. Lancet 1996, 348:1467-by screening for fecal occult blood. Minnesota Colon Cancer

Lee, Jeffrey K; Groessl, Erik J; Ganiats, Theodore G; Ho, Samuel B

2011-01-01T23:59:59.000Z

431

Lung cancer epidemiology in New Mexico uranium miners. Progress report, March 1, 1991--November 30, 1991  

Science Conference Proceedings (OSTI)

This investigation assesses the health effects of radon progeny exposure in New Mexico uranium miners. Cumulative exposures sustained by most New Mexico miners are well below those received earlier in the Colorado Plateau. This project utilizes the research opportunity offered by New Mexico miners to address unresolved issues related to radon progeny exposure: (1) the lung cancer risk of lower levels of exposure, (2) interaction between radon progeny exposure and cigarette smoking in the causation of lung cancer, (3) the relationship between lung cancer histologic type and radon progeny exposure, and (4) possible effects of radon progeny exposure other than lung cancer. A cohort study of 3800 men with at least one year of underground uranium mining experience in New Mexico is in progress. Results are discussed.

Samet, J.M.

1991-11-01T23:59:59.000Z

432

Trans Fats in FoodChapter 2 Trans Fats and Cancer  

Science Conference Proceedings (OSTI)

Trans Fats in Food Chapter 2 Trans Fats and Cancer Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry Press Downloadable pdf of Chapter 2

433

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo  

E-Print Network (OSTI)

Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% of all cancers today. ...

Dhar, Shanta

434

EA-0965: Cancer Research Center Indiana University School of Medicine, Argonne, Illinois  

Energy.gov (U.S. Department of Energy (DOE))

This EA evaluates the environmental impacts of the proposal to construct and equip the proposed Cancer Research Center (CRC), which would be located on the Indianapolis campus of the Indiana...

435

Flaxseed in Human Nutrition, 2nd EditionChapter 9 Flaxseed, Lignans, and Cancer  

Science Conference Proceedings (OSTI)

Flaxseed in Human Nutrition, 2nd Edition Chapter 9 Flaxseed, Lignans, and Cancer Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry Press Downloadable pdf ...

436

Flaxseed in Human Nutrition, 2nd EditionChapter 11 a-Linolenic Acid and Cancer  

Science Conference Proceedings (OSTI)

Flaxseed in Human Nutrition, 2nd Edition Chapter 11 a-Linolenic Acid and Cancer Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry Press Downloadable pdf ...

437

A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy  

E-Print Network (OSTI)

The use of nanotechnology to engineer drug delivery vehicles comprised of controlled release polymers with targeting molecules has the potential to revolutionize cancer therapy, among other diseases. Although a myriad of ...

Valencia, Pedro M. (Pedro Miguel)

2013-01-01T23:59:59.000Z

438

Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report  

SciTech Connect

This technical report presents the age-adjusted total, and race and sex specific geographic patterns of cancer mortality for South Carolina (SC) counties utilizing the 1953--1987 average annual age-adjusted mortality rates (AAMRs). The mortality information was obtained from the State Cancer Control Map and Data Program produced by the National Cancer Institute , Centers for Disease Control and the American Cancer Society. The AAMRs for selected primary sites are classified as significantly different or not significantly different from the corresponding United States and SC mortality rates. Categories for classification of the rates are determined using 95% confidence intervals. Geographic patterns of significantly high county AAMRs are identified and discussed. Individual county rates are not emphasized. The terminology, mortality rates used throughout this report pertains to the 1953--1987 AAMRS.

Dunbar, J.B.

1993-05-01T23:59:59.000Z

439

Cancer and birth defects surveillance system for communities around the Savannah River Site  

SciTech Connect

This technical report presents the age-adjusted total, and race and sex specific geographic patterns of cancer mortality for South Carolina (SC) counties utilizing the 1953--1987 average annual age-adjusted mortality rates (AAMRs). The mortality information was obtained from the State Cancer Control Map and Data Program produced by the National Cancer Institute , Centers for Disease Control and the American Cancer Society. The AAMRs for selected primary sites are classified as significantly different or not significantly different from the corresponding United States and SC mortality rates. Categories for classification of the rates are determined using 95% confidence intervals. Geographic patterns of significantly high county AAMRs are identified and discussed. Individual county rates are not emphasized. The terminology, mortality rates used throughout this report pertains to the 1953--1987 AAMRS.

Dunbar, J.B.

1993-05-01T23:59:59.000Z

440

Method for detecting cancer in a single cell using mitochondrial correlation microscopy  

SciTech Connect

A method for distinguishing a normal cell from an abnormal cell, such as, for example a cancer cell or diseased cell, of the same tissue type using mitochondrial correlation microscopy.

Gourley, Paul L. (Albuquerque, NM)

2012-03-06T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Resolving Cancer Heterogeneity by Single Cell Sequencing (7th Annual SFAF Meeting, 2012)  

Science Conference Proceedings (OSTI)

Xun Xu on "Resolving Cancer Heterogeneity by Single Cell Sequencing" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

Xu, Xun [BGI

2012-06-01T23:59:59.000Z

442

Multimodal spectroscopy : real-time diagnosis of breast cancer during core needle biopsy  

E-Print Network (OSTI)

Early detection of breast cancer is critical for improved survival. Currently, breast abnormalities are diagnosed based on a histopathological evaluation of tissue removed during core needle biopsy. Microcalcifications are ...

Volynskaya, Zoya I

2010-01-01T23:59:59.000Z

443

Integrated analysis of breast cancer cell lines reveals unique signaling pathways  

Science Conference Proceedings (OSTI)

Cancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EGFR-MAPK pathway is common in breast cancer, though the manner in which deregulation occurs varies between both individuals and cancer subtypes. We were interested in identifying subnetworks within the EGFR-MAPK pathway that are similarly deregulated across subsets of breast cancers. To that end, we mapped genomic, transcriptional and proteomic profiles for 30 breast cancer cell lines onto a curated Pathway Logic symbolic systems model of EGFR-MEK signaling. This model was comprised of 539 molecular states and 396 rules governing signaling between active states. We analyzed these models and identified several subtype specific subnetworks, including one that suggested PAK1 is particularly important in regulating the MAPK cascade when it is over-expressed. We hypothesized that PAK1 overexpressing cell lines would have increased sensitivity to MEK inhibitors. We tested this experimentally by measuring quantitative responses of 20 breast cancer cell lines to three MEK inhibitors. We found that PAK1 over-expressing luminal breast cancer cell lines are significantly more sensitive to MEK inhibition as compared to those that express PAK1 at low levels. This indicates that PAK1 over-expression may be a useful clinical marker to identify patient populations that may be sensitive to MEK inhibitors. All together, our results support the utility of symbolic system biology models for identification of therapeutic approaches that will be effective against breast cancer subsets.

Heiser, Laura M.; Wang, Nicholas J.; Talcott, Carolyn L.; Laderoute, Keith R.; Knapp, Merrill; Guan, Yinghui; Hu, Zhi; Ziyad, Safiyyah; Weber, Barbara L.; Laquerre, Sylvie; Jackson, Jeffrey R.; Wooster, Richard F.; Kuo, Wen-Lin; Gray, Joe W.; Spellman, Paul T.

2009-03-31T23:59:59.000Z

444

Development of chemotherapies for hormone-dependent breast and prostate cancers  

E-Print Network (OSTI)

Cancer is a leading cause of human mortality worldwide, and is expected to soon become the overall leading cause of death in the United States. Some cancers are hormone-related, including the sex-specific cancers of the breast (predominantly in women) and prostate (in men). In both cases, early stage tumors are responsive to inhibitory endocrine-based therapies. However, both cancers progress to hormone-nonresponsive states and this is in part due to altered properties of the primary nuclear hormone receptor signaling pathway (estrogen receptor [ER] in breast; androgen receptor [AR] in prostate). Other nuclear receptors are thus being investigated as therapeutic targets due to their crosstalk with hormone receptor pathways and these include the aryl hydrocarbon receptor (AhR), peroxisome proliferator activated receptor ?(PPAR?, retinoic acid receptor and retinoid X receptor (RAR/RXR), and vitamin D receptor (VDR). Previous studies have demonstrated that the AhR mediates chemoprotective, antiestrogenic, and tumoristatic effects in experimental models, and relatively non-toxic selective aryl hydrocarbon receptor modulators (SAhRMs) have been developed. Studies in this dissertation have investigated the therapeutic properties of a new class of compounds related to the SAhRM 3,3‘-diindolylmethane (DIM) in models of breast cancer. Additionally, the potential therapeutic role of the AhR in human prostate cancer cells has been investigated. Several ring- and methylene-substituted DIMs exhibited antiestrogenic and tumoristatic activities in breast cancer cells and in carcinogen-induced rat mammary tumors. At least some of the methylene-substituted DIMs act through PPAR?. The AhR is expressed in LNCaP and iv 22Rv1 prostate cancer cells and AhR agonists inhibit cell growth and AR-induced transactivation through pathways independent of androgen receptor downregulation.

Morrow, Michael Derek

2003-12-01T23:59:59.000Z

445

Radiation-induced cancer and its modifying factor among A-bomb survivors  

SciTech Connect

The Atomic Bomb Casualty Commission (ABCC) and its successor, the Radiation Effects Research Foundation, have conducted a long-term follow-up study of a cohort of 120,000 atomic bomb (A-bomb) survivors and non-exposed controls since 1950. The most recent findings regarding cancer mortality and incidence in this cohort can be briefly summarized as follows: 1) An increase in leukemia mortality among A-bomb survivors peaked 5-6 years after the bombing and has decreased with time thereafter. In addition to leukemia, the incidence of cancer of the lung, breast, esophagus, stomach, colon, thyroid, ovary, urinary tract, and multiple myeloma increases with dose. At present, there is no indication of an increase in cancer of the rectum or uterus among A-bomb survivors. In general, radiation-induced solid cancers begin to appear after the age at which they are normally prone to develop, and have continued to increase with time in proportion to the natural increase in mortality of the control group. 2) There are factors which modify the effects of radiation, such as age at the time of bombing (ATB) and sex. Sensitivity to radiation, in terms of cancer induction, is higher for persons who were young ATB in general, than for those who were older ATB. 3) There was no increase in childhood cancer among those exposed while in utero, but there is a recent indication of an increase in cancer incidence among these persons as they age. 4) There seems to be no interaction in a multiplicative way between radiation and smoking and lung cancer induction.

Kato, H.

1987-01-01T23:59:59.000Z

446

Radioimmunoguided surgery using iodine 125 B72. 3 in patients with colorectal cancer  

SciTech Connect

Preliminary data using B72.3 murine monoclonal antibody labeled with iodine 125 suggested that both clinically apparent as well as occult sites of colorectal cancer could be identified intraoperatively using a hand-held gamma detecting probe. We report the preliminary data of a multicenter trial of this approach in patients with primary or recurrent colorectal cancer. One hundred four patients with primary, suspected, or known recurrent colorectal cancer received an intravenous infusion of 1 mg of B72.3 monoclonal antibody radiolabeled with 7.4 x 10 Bq of iodine 125. Twenty-six patients with primary colorectal cancer and 72 patients with recurrent colorectal cancer were examined. Using the gamma detecting probe, 78% of the patients had localization of the antibody in their tumor; this included 75% of primary tumor sites and 63% of all recurrent tumor sites; 9.2% of all tumor sites identified represented occult sites detected only with the gamma detecting probe. The overall sensitivity was 77% and a predictive value of a positive detection was 78%. A total of 30 occult sites in 26 patients were identified. In patients with recurrent cancer, the antibody study provided unique data that precluded resection in 10 patients, and in another eight patients it extended the potentially curative procedure.

Cohen, A.M.; Martin, E.W. Jr.; Lavery, I.; Daly, J.; Sardi, A.; Aitken, D.; Bland, K.; Mojzisik, C.; Hinkle, G. (Memorial Sloan-Kettering Cancer Center, New York, NY (USA))

1991-03-01T23:59:59.000Z

447

Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer  

Science Conference Proceedings (OSTI)

Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein (KSP), a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. Clinical studies of ispinesib have demonstrated a 9% response rate in patients with locally advanced or metastatic breast cancer, and a favorable safety profile without significant neurotoxicities, gastrointestinal toxicities or hair loss. To better understand the potential of ispinesib in the treatment of breast cancer we explored the activity of ispinesib alone and in combination several therapies approved for the treatment of breast cancer. We measured the ispinesib sensitivity and pharmacodynamic response of breast cancer cell lines representative of various subtypes in vitro and as xenografts in vivo, and tested the ability of ispinesib to enhance the anti-tumor activity of approved therapies. In vitro, ispinesib displayed broad anti-proliferative activity against a panel of 53 breast cell-lines. In vivo, ispinesib produced regressions in each of five breast cancer models, and tumor free survivors in three of these models. The effects of ispinesib treatment on pharmacodynamic markers of mitosis and apoptosis were examined in vitro and in vivo, revealing a greater increase in both mitotic and apoptotic markers in the MDA-MB-468 model than in the less sensitive BT-474 model. In vivo, ispinesib enhanced the anti-tumor activity of trastuzumab, lapatinib, doxorubicin, and capecitabine, and exhibited activity comparable to paclitaxel and ixabepilone. These findings support further clinical exploration of KSP inhibitors for the treatment of breast cancer.

Purcell, James W; Davis, Jefferson; Reddy, Mamatha; Martin, Shamra; Samayoa, Kimberly; Vo, Hung; Thomsen, Karen; Bean, Peter; Kuo, Wen Lin; Ziyad, Safiyyah; Billig, Jessica; Feiler, Heidi S; Gray, Joe W; Wood, Kenneth W; Cases, Sylvaine

2009-06-10T23:59:59.000Z

448

Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer  

Science Conference Proceedings (OSTI)

Purpose: To investigate testicular doses contributed by kilovoltage cone-beam computed tomography (kVCBCT) during image-guided radiotherapy (IGRT) of prostate cancer. Methods and Materials: An EGS4 Monte Carlo code was used to calculate three-dimensional dose distributions from kVCBCT on 3 prostate cancer patients. Absorbed doses to various organs were compared between intensity-modulated radiotherapy (IMRT) treatments and kVCBCT scans. The impact of CBCT scanning mode, kilovoltage peak energy (kVp), and CBCT field span on dose deposition to testes and other organs was investigated. Results: In comparison with one 10-MV IMRT treatment, a 125-kV half-fan CBCT scan delivered 3.4, 3.8, 4.1, and 5.7 cGy to the prostate, rectum, bladder, and femoral heads, respectively, accounting for 1.7%, 3.2%, 3.2%, and 8.4% of megavoltage photon dose contributions. However, the testes received 2.9 cGy from the same CBCT scan, a threefold increase as compared with 0.7 cGy received during IMRT. With the same kVp, full-fan mode deposited much less dose to organs than half-fan mode, ranging from 9% less for prostate to 69% less for testes, except for rectum, where full-fan mode delivered 34% more dose. As photon beam energy increased from 60 to 125 kV, kVCBCT-contributed doses increased exponentially for all organs, irrespective of scanning mode. Reducing CBCT field span from 30 to 10 cm in the superior-inferior direction cut testicular doses from 5.7 to 0.2 cGy in half-fan mode and from 1.5 to 0.1 cGy in full-fan mode. Conclusions: Compared with IMRT, kVCBCT-contributed doses to the prostate, rectum, bladder, and femoral heads are clinically insignificant, whereas dose to the testes is threefold more. Full-fan CBCT usually deposits much less dose to organs (except for rectum) than half-fan mode in prostate patients. Kilovoltage CBCT-contributed doses increase exponentially with photon beam energy. Reducing CBCT field significantly cuts doses to testes and other organs.

Deng Jun, E-mail: jun.deng@yale.edu [Department of Therapeutic Radiology, Yale University, New Haven, CT (United States); Chen Zhe; Yu, James B.; Roberts, Kenneth B.; Peschel, Richard E.; Nath, Ravinder [Department of Therapeutic Radiology, Yale University, New Haven, CT (United States)

2012-01-01T23:59:59.000Z

449

Estimation of radiation-induced cancer from three-dimensional dose distributions: Concept of organ equivalent dose  

SciTech Connect

Purpose: Estimates of secondary cancer risk after radiotherapy are becoming more important for comparative treatment planning. Modern treatment planning systems provide accurate three-dimensional dose distributions for each individual patient. These data open up new possibilities for more precise estimates of secondary cancer incidence rates in the irradiated organs. We report a new method to estimate organ-specific radiation-induced cancer incidence rates. The concept of an organ equivalent dose (OED) for radiation-induced cancer assumes that any two dose distributions in an organ are equivalent if they cause the same radiation-induced cancer incidence. Methods and Materials: The two operational parameters of the OED concept are the organ-specific cancer incidence rate at low doses, which is taken from the data of the atomic bomb survivors, and cell sterilization at higher doses. The effect of cell sterilization in various organs was estimated by analyzing the secondary cancer incidence data of patients with Hodgkin's disease who were treated with radiotherapy in between 1962 and 1993. The radiotherapy plans used at the time the patients had been treated were reconstructed on a fully segmented whole body CT scan. The dose distributions were calculated in individual organs for which cancer incidence data were available. The model parameter that described cell sterilization was obtained by analyzing the dose and cancer incidence rates for the individual organs. Results: We found organ-specific cell radiosensitivities that varied from 0.017 for the mouth and pharynx up to 1.592 for the bladder. Using the two model parameters (organ-specific cancer incidence rate and the parameter characterizing cell sterilization), the OED concept can be applied to any three-dimensional dose distribution to analyze cancer incidence. Conclusion: We believe that the concept of OED presented in this investigation represents a first step in assessing the potential risk of secondary cancer induction after the clinical application of radiotherapy.

Schneider, Uwe [Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, City Hospital Triemli, Zurich (Switzerland)]. E-mail: uwe.schneider@psi.ch; Zwahlen, Daniel [Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, City Hospital Triemli, Zurich (Switzerland); Ross, Dieter [Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, City Hospital Triemli, Zurich (Switzerland); Kaser-Hotz, Barbara [Division of Diagnostic Imaging and Radio-Oncology, Vetsuisse Faculty, University of Zuerich, Zurich (Switzerland)

2005-04-01T23:59:59.000Z

450

EPRI Comments on a UK Case-Control Study of Magnetic Fields from High Voltage Power Lines and Childhood Cancer  

Science Conference Proceedings (OSTI)

A paper, entitled "Childhood cancer and magnetic fields from high voltage power lines in England and Wales: a case-control study," was published in the British Journal of Cancer on September 28, 2010. The authors assessed the association between exposure to EMF from power lines at the address of birth and childhood cancer. The current paper provides additional results to a study published earlier from the same data set in 2005. These EPRI comments provide an overview of study findings, conclusions, stren...

2010-12-22T23:59:59.000Z

451

Cervicopectoral flap in head and neck cancer surgery  

E-Print Network (OSTI)

© 2003 Copcu et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Flapsreconstructionhead neckcancercarcinomatumorcosmesis Background: Reconstruction of the head and neck after adequate resection of primary tumor and neck dissection is a challenge. It should be performed at one sitting in advanced tumors. Defects caused by the resection should be closed with flaps which match in color, texture and hair bearing characteristics with the face. Cervicopectoral flap is a one such flap from chest and neck skin mainly used to cover the cheek defects. Methods: This study included twelve patients presenting with cancer of the head and neck to Izmir Ataturk Training Hospital and Adnan Menderes University Hospital. Tumor resection and neck dissection was performed in one session by the same surgeon. A single incision was made and a medially based cervicopectoral fascio-cutaneous flap was used for surgical exposure in neck dissection and for closure of defects after tumor resection. Results: There was no major complication. Two flaps had partial superficial epidermolysis at the

Technical Innovations; Eray Copcu; Kubilay Metin; Alper Aktas; Nazan S Sivrioglu; Yücel Öztan; Nazan S Sivrioglu; Yücel Öztan

2003-01-01T23:59:59.000Z

452

Uncertainty and sensitivity analysis of chronic exposure results with the MACCS reactor accident consequence model  

Science Conference Proceedings (OSTI)

Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the chronic exposure pathways associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 75 imprecisely known input variables on the following reactor accident consequences are studied: crop growing season dose, crop long-term dose, water ingestion dose, milk growing season dose, long-term groundshine dose, long-term inhalation dose, total food pathways dose, total ingestion pathways dose, total long-term pathways dose, total latent cancer fatalities, area-dependent cost, crop disposal cost, milk disposal cost, population-dependent cost, total economic cost, condemnation area, condemnation population, crop disposal area and milk disposal area. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: dry deposition velocity, transfer of cesium from animal feed to milk, transfer of cesium from animal feed to meat, ground concentration of Cs-134 at which the disposal of milk products will be initiated, transfer of Sr-90 from soil to legumes, maximum allowable ground concentration of Sr-90 for production of crops, fraction of cesium entering surface water that is consumed in drinking water, groundshine shielding factor, scale factor defining resuspension, dose reduction associated with decontamination, and ground concentration of 1-131 at which disposal of crops will be initiated due to accidents that occur during the growing season.

Helton, J.C. [Arizona State Univ., Tempe, AZ (United States); Johnson, J.D.; Rollstin, J.A. [Gram, Inc., Albuquerque, NM (United States); Shiver, A.W.; Sprung, J.L. [Sandia National Labs., Albuquerque, NM (United States)

1995-01-01T23:59:59.000Z

453

Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers  

E-Print Network (OSTI)

random hexamers and oligo-dT pri- mers, according to the manufacturer’s instructions. Breast cell lines culture Breast cancer (PMC42, MCF-7 and SUM-159) and nor- mal breast (MCF-10A) cell lines were cultured as pre- viously described [29... in the Chromatin Immunoprecipitation section. Chromatin Immunoprecipitation (ChIP) ChIP experiments were performed using chromatin extracted from SUM-159 (cancer), PMC42 (cancer), MCF-7 (cancer) and MCF10-A (normal) breast cell lines with antibodies against RNA...

Maia, Ana-Teresa; Antoniou, Antonis C; O'Reilly, Martin; Samarajiwa, Shamith; Dunning, Mark; Kartsonaki, Christiana; Chin, Suet-Feung; Curtis, Christina N; McGuffog, Lesley; Domchek, Susan M; Embrace, Embrace; Easton, Douglas F; Peock, Susan; Frost, Debra; Evans, D Gareth; Eeles, Ros; Izatt, Louise; Adlard, Julian; Eccles, Diana; Gemo, Gemo; Sinilnikova, Olga M; Mazoyer, Sylvie; Stoppa-Lyonnet, Dominique; Gauthier-Villars, Marion; Faivre, Laurence; Venat-Bouvet, Laurence; Delnatte, Capucine; Nevanlinna, Heli; Couch, Fergus J; Godwin, Andrew K; Caligo, Maria-Adelaide; Swe-brca, Swe-brca; Barkardottir, Rosa B; kConFab, kConFab; Chen, Xiaoqing; Beesley, Jonathan; Healey, Sue; Caldas, Carlos; Chenevix-Trench, Georgia; Ponder, Bruce AJ

2012-04-18T23:59:59.000Z

454

The Association between Cancers and Low Level Radiation: an evaluation of the epidemiological evidence at the Hanford Nuclear Weapons Facility  

E-Print Network (OSTI)

indiv. indiv. Gilbertetal. (Hanford & Combined) Gilbertetal.on both radiation and the Hanford facility. The data used toG. Radiation exposures of Hanford workers dying from cancer

Britton, Julie

2010-01-01T23:59:59.000Z

455

Carotenoids & Retinoids; Molecular Aspects and Health IssuesChapter 11 Retinoids and Carotenoids as Cancer Chemopreventive Agents  

Science Conference Proceedings (OSTI)

Carotenoids & Retinoids; Molecular Aspects and Health Issues Chapter 11 Retinoids and Carotenoids as Cancer Chemopreventive Agents Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press   ...

456

3.0 CANCER RISKS FROM ON-SITE EXPOSURE This chapter examines the potential scenarios, exposure pathways, and risks of cancer to humans  

E-Print Network (OSTI)

pathways, and risks of cancer to humans that may be posed by exposure to TENORM from abandoned uranium mine of uranium mine TENORM wastes,1 there are several possible exposure scenarios for humans to the various, the primary exposure scenarios to TENORM wastes at uranium mines would involve recreational use of the site

457

Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.  

E-Print Network (OSTI)

of BRCA1/2. Breast Cancer Research 2011 13:R110. Submit yourStayner. The Institute of Cancer Research and Royal Marsdenis supported by Cancer Research UK Grants C1287/A10118 and

2011-01-01T23:59:59.000Z

458

Condensate induced water hammer in a steam distribution system results in fatality  

SciTech Connect

Water hammer event s in steam distribution piping interrupt service and have the potential to cause serious injury and property damage. Conditions of condensation induced water hammer are discussed and recommendations aimed to improve safety of steam systems are presented. Condensate induced water hammer events at Hanford, a DOE facility, are examined.

Debban, H.L.; Eyre, L.E.

1996-02-01T23:59:59.000Z

459

Session: Non-fatality and habitat impacts on birds from wind energy development  

SciTech Connect

This session at the Wind Energy and Birds/Bats workshop was consisted of one paper presentation followed by a discussion/question and answer period. The session focused on discussion of non-collision impacts of wind energy projects on birds, primarily impacts to habitat. The presentation included information about the impacts of habitat fragmentation, disturbance, and site avoidance from wind turbines, as well as from roads, transmission facilities, and other related construction at wind project sites. Whether birds habituate to the presence of turbines and the influence of regional factors were also addressed. The paper given by Dale Strickland was titled ''Overview of Non-Collision Related Impacts from Wind Projects''.

Strickland, Dale

2004-09-01T23:59:59.000Z

460

The Femme Fatale Tells Her Story: Dorothy Hughes and WWII Crime Fiction  

E-Print Network (OSTI)

Most studies of feminism in crime fiction begin with authorsand 80s. However, popular crime fiction of the noir andmale- only” roots of the crime novel cannot be ignored, but

Rolens, Claire

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "latent cancer fatality" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Development, characterization and transcriptional profiling of a mouse model of fatal infectious diarrhea and colitis  

E-Print Network (OSTI)

Citrobacter rodentium is a naturally occurring murine bacterial pathogen which is used to model human diarrheagenic E. coli (EPEC and EHEC) infections in mice. C. rodentium causes colonic hyperplasia and a variable degree ...

Borenshtein, Diana

2007-01-01T23:59:59.000Z

462

Spontaneous generation of prion infectivity in fatal familial insomnia knock-in mice  

E-Print Network (OSTI)

A crucial tenet of the prion hypothesis is that misfolding of the prion protein (PrP) induced by mutations associated with familial prion disease is, in an otherwise normal mammalian brain, sufficient to generate the ...

Faas, Henryk

463

Session: Non-fatality and habitat impacts on birds from wind energy development  

DOE Green Energy (OSTI)

This session at the Wind Energy and Birds/Bats workshop was consisted of one paper presentation followed by a discussion/question and answer period. The session focused on discussion of non-collision impacts of wind energy projects on birds, primarily impacts to habitat. The presentation included information about the impacts of habitat fragmentation, disturbance, and site avoidance from wind turbines, as well as from roads, transmission facilities, and other related construction at wind project sites. Whether birds habituate to the presence of turbines and the influence of regional factors were also addressed. The paper given by Dale Strickland was titled ''Overview of Non-Collision Related Impacts from Wind Projects''.

Strickland, Dale

2004-09-01T23:59:59.000Z

464

Are You Saved? HIM, an Intranet-based Expert System Reduces Fatality Risk  

SciTech Connect

On July 28, 1998 a devastating accident occurred at the Test Reactor Area of the Idaho National Engineering and Environmental Laboratory (INEEL). The accident cost a man his life and caused injury to others. In addition to the significant human loss, Lockheed Martin (LMITCO) experienced economic losses that reached millions of dollars. LMITCO eventually lost the managing and operating contract of a premier Department of Energy Laboratory. Just as with the INEEL, companies throughout industry today must face an ever increasingly complex world of government alphabet soup of regulations—OSHA, CAA, TSCA, FIFRA, ADA, and more. For businesses, non-compliance can quickly evaporate profits. For humans, mistakes can seriously affect health, and some work areas are so complicated that a single event could cost human life. Finally, adherence to the regulations can protect the community and the environment. Compliance with regulations is essential and multifaceted. Regulations require interpretation into company policy. Policies must be implemented as standard work practices. The workforce must be trained to follow the procedures. Management must coordinate flow down of requirements and policy for standardized work planning processes and consistent compliance with regulations. Implementing controls to ensure absolute compliance can be a very costly and cumbersome effort, thus, a graded approach is necessary to ensure cost effectiveness and relevance to actual work. The INEEL has developed technology for hazard evaluation and work planning called the Hazards Identification and Mitigation System. The HIM System is a web-based expert system that is available to all INEEL employees through the company Intranet. This tool simplifies and streamlines work planning by using a graded approach to standardize practices. The tool assists in evaluating hazards and ascertaining the required rigor for planning work. The tool integrates the knowledge of INEEL and DOE experts and previously proven review checklists and processes.The manual process is lengthy—sometimes taking 12 to 18 hours to complete. As such, it is difficult, prone to errors, and very tempting to shortcut. Automation of this process through the HIM system reduced a monumental hazard identification task for each work order, into a streamlined, efficient, and accurate process that can be completed in less than one hour. The result is that the process gets done, the regulations are met, and risk to human life is reduced.

Crofts, Von David; Simpson, Wayne Winger; Hopkins, Deborah Jean; Hawke, Scott Allen

2000-06-01T23:59:59.000Z

465

Fatal Attraction: Focality, Naivete and Sophistication in Experimental “Hide and Seek” Games  

E-Print Network (OSTI)

experiments with ultimatum and weak-link coordination games,in Ultimatum Bargaining and 'Weak Link' Coordination Games,"

Crawford, Vincent P.; Iriberri, Nagore

2005-01-01T23:59:59.000Z

466

Actuarial risk assessment of expected fatalities attributable to carbon capture and storage in 2050  

E-Print Network (OSTI)

natural gas storage industry. But in Chemery, 17 halshs-00487175,version2-10Feb2011 #12;France, technical has occurred. According to Damen et al. (2006), nine natural gas storage reservoirs out of 900 to data on natural gas and hazardous liquids pipeline safety in USA and Europe. Finally, analogy

467

Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987  

Science Conference Proceedings (OSTI)

This report presents, for the first time, comprehensive data on the incidence of solid cancer and risk estimates for A-bomb survivors in the extended Life Span Study (LSS-E85) cohort. Among 79,972 individuals, 8613 first primary solid cancers were diagnosed between 1958 and 1987. As part of the standard registration process of the Hiroshima and Nagasaki tumor registries, cancer cases occurring among members of the LSS-E85 cohort were identified using a computer linkage system supplemented by manual searches. Special efforts were made to ensure complete case ascertainment, data quality and data consistency in the two cities. For all sites combined, 75% of the cancers were verified histologically, 6% were diagnosed by direct observation, 8% were based on a clinical diagnosis, and 12.6% were ascertained by death certificate only. A standard set of analyses was carried out for each of the organs and organ systems considered. Depending on the cancer site, Dosimetry System 1986 (DS86) organ or kerma doses were used for computing risk estimates. Analyses were based on a general excess relative risk model (the background rate times one plus the excess relative risk). Analyses carried out for each site involved fitting the background model with no dose effect, a linear dose-response model with no effect modifiers, a linear-quadratic dose-response model with no effect modifiers, and a series of linear dose-response models that included each of the covariates (sex, age at exposure, time since exposure, attained age and city) individually as effect modifiers. Because the tumor registries ascertain cancers in the registry catchment areas only, an adjustment was made for the effects of migration. In agreement with prior LSS findings, a statistically significant excess risk for all solid cancers was demonstrated. 116 refs., 8 figs., 78 tabs.

Thompson, D.E. (Radiation Effects Research Foundation, Nagasaki (Japan) George Washington Univ., Rockville, MD (United States) Radiation Effects Research Foundation, Hiroshima (Japan)); Soda, Midori (Radiation Effects Research Foundation, Nagasaki (Japan)); Izumi, Shizue; Mabuchi, Kiyohiko (Radiation Effects Research Foundation, Hiroshima (Japan)); Ron, E.; Tokunaga, Masayoshi (Radiation Effects Research Foundation, Hiroshima (Japan) National Cancer Institute, Bethesda, MD (United States)); Ochikubo, Sachio (Hiroshima City Medical Association (Japan)); Sugimoto, Sumio (Hiroshima Prefectural Medical Association (Japan)); Ikeda, Takayoshi (Nagasaki Univ. Medical School (Japan)); Terasaki, Masayuki (Nagasaki City Medical Association (Japan)) (and others)

1994-02-01T23:59:59.000Z

468

Percentage of Cancer Volume in Biopsy Cores Is Prognostic for Prostate Cancer Death and Overall Survival in Patients Treated With Dose-Escalated External Beam Radiotherapy  

SciTech Connect

Purpose: To investigate the prognostic utility of the percentage of cancer volume (PCV) in needle biopsy specimens for prostate cancer patients treated with dose-escalated external beam radiotherapy. Methods and Materials: The outcomes were analyzed for 599 men treated for localized prostate cancer with external beam radiotherapy to a minimal planning target volume dose of 75 Gy (range, 75-79.2). We assessed the effect of PCV and the pretreatment and treatment-related factors on the freedom from biochemical failure, freedom from metastasis, cause-specific survival, and overall survival. Results: The median number of biopsy cores was 7 (interquartile range, 6-12), median PCV was 10% (interquartile range, 2.5-25%), and median follow-up was 62 months. The PCV correlated with the National Comprehensive Cancer Network risk group and individual risk features, including T stage, prostate-specific antigen level, Gleason score, and percentage of positive biopsy cores. On log-rank analysis, the PCV stratified by quartile was prognostic for all endpoints, including overall survival. In addition, the PCV was a stronger prognostic factor than the percentage of positive biopsy cores when the two metrics were analyzed together. On multivariate analysis, the PCV predicted a worse outcome for all endpoints, including freedom from biochemical failure, (hazard ratio, 1.9; p = .0035), freedom from metastasis (hazard ratio, 1.7, p = .09), cause-specific survival (hazard ratio, 3.9, p = .014), and overall survival (hazard ratio, 1.8, p = .02). Conclusions: For patients treated with dose-escalated external beam radiotherapy, the volume of cancer in the biopsy specimen adds prognostic value for clinically relevant endpoints, particularly in intermediate- and high-risk patients. Although the PCV determination is more arduous than the percentage of positive biopsy cores, it provides superior risk stratification.

Vance, Sean M.; Stenmark, Matthew H.; Blas, Kevin; Halverson, Schulyer [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Hamstra, Daniel A., E-mail: dhamm@umich.edu [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Feng, Felix Y. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Department of Radiation Oncology, Veterans Affairs Medical Center, Ann Arbor, Michigan (United States)

2012-07-01T23:59:59.000Z

469

Hiroshima and Nagasaki: New doses, risks, and their implications  

SciTech Connect

This presentation summarizes the recent re-evaluations of the dose and risk of cancer among survivors of the atomic bombing of Hiroshima and Nagasaki. It addresses briefly their limitations, and describes some of their implications for the lifetime projection of the risk of a fatal cancer following exposure to ionizing radiation.

Schull, W.J.; Shimizu, Y.; Kato, H. (Univ. of Texas Health Science Center, Houston (USA))

1990-07-01T23:59:59.000Z

470

Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Colon Cancer  

E-Print Network (OSTI)

Non-steroidal anti-inflammatory drugs (NSAIDs) and their NO derivatives (NO-NSAIDs), and synthetic analogs are highly effective as anticancer agents that exhibit relatively low toxicity compared to most clinically used drugs. However, the mechanisms of action for NSAIDs and NO-NSAIDs are not well defined and this has restricted their clinical applications and applications for combined therapies. Earlier studies from our laboratory reported that specificity protein (Sp) transcription factors (Sp1, Sp3 and Sp4) are overexpressed in several types of human cancers including colon cancer and many Sp-regulated genes are pro-oncogenic and individual targets for cancer chemotherapy. Based on published results showing that NSAIDs downregulate several putative Sp-regulated genes, we hypothesized that the anticancer properties of NSAIDs may be due, in part, to downregulation of Sp transcription factors. NSAIDs including aspirin and tolfenamic acid (TA) and nitro derivatives of NSAIDs such as GT-094 have been investigated in colon cancer cells and in vivo xenograft models. Aspirin and TA induced apoptosis and decreased colon cancer cell growth and tumor growth in vivo and downregulated genes associated with cell growth, survival, and angiogenesis. Previous RNA interference studies in this laboratory have shown that many of these genes are regulated, in part, by Sp transcription factors Sp1, Sp3 and Sp4 that are overexpressed in colon and other cancer cell lines. Not surprisingly, these NSAIDs also decreased Sp1, Sp3 and Sp4 proteins and Sp-regulated gene products in colon cancer cells and this was due to caspase-dependent proteolysis of Sp1, Sp3 and Sp4 proteins. Aspirin-induced activation of caspases and degradation of Sp1, Sp3 and Sp4 was due to sequestration of zinc and could be reversed by addition of zinc sulphate, whereas TA mediated induction of caspases was independent of zinc ions and is currently being investigated. GT-094 is a novel NO chimera-containing NSAID, which also inhibited colon cancer cell proliferation and induced apoptosis; these effects were accompanied by decreased mitochondrial membrane potential (MMP) and induction of reactive oxygen species (ROS), and were reversed after cotreatment with the antioxidant glutathione. GT-094 also downregulated Sp and Sp-dependent gene products and was due to decreased expression of microRNA-27a (miR-27a) and induction of ZBTB10, an Sp transcriptional repressor that is regulated by miR-27a in colon cancer cells. Moreover, the effects of GT-094 on Sp1, Sp3, Sp4, miR-27a and ZBTB10 were also inhibited by glutathione suggesting that the anticancer activity of GT-094 in colon cancer cells is due, in part, to ROS-dependent disruption of miR-27a:ZBTB10. The importance of ROS induction in targeting Sp transcription factors was also confirmed using pro-oxidants such as ascorbic acid, hydrogen peroxide and t-butyl hydroperoxide and similar results have been observed in collaborative studies with other ROS inducers in colon cancer cells. Many cancer cell lines and tumors exhibit addiction to non-oncogenes such as Sp1, Sp3 and Sp4 for maintaining the oncogenic phenotype and future research will focus on the mechanisms of ROS-mediated targeting of Sp transcription factors which represents a novel approach for cancer chemotherapy.

Pathi, Satya

2012-08-01T23:59:59.000Z

471

Role of CYP1B1 in PAH-DNA Adduct Formation and Breast Cancer Risk  

NLE Websites -- All DOE Office Websites (Extended Search)

Role of CYP1B1 in PAH-DNA Adduct Formation and Breast Cancer Risk Role of CYP1B1 in PAH-DNA Adduct Formation and Breast Cancer Risk Title Role of CYP1B1 in PAH-DNA Adduct Formation and Breast Cancer Risk Publication Type Report Year of Publication 2010 Authors Goth-Goldstein, Regine, Marion L. Russell, Donghui Li, Ana P. Müller, Maira Caleffi, Joao Eschiletti, Marcia Graudenz, and Michael D. Sohn Date Published 04/2010 Publisher Lawrence Berkeley National Laboratory City Berkeley Abstract This study investigated the hypothesis that increased exposure to polycyclic aromatic hydrocarbons (PAHs) increases breast cancer risk. PAHs are products of incomplete burning of organic matter and are present in cigarette smoke, ambient air, drinking water, and diet. PAHs require metabolic transformation to bind to DNA, causing DNA adducts, which can lead to mutations and are thought to be an important pre-cancer marker. In breast tissue, PAHs appear to be metabolized to their cancer-causing form primarily by the cytochrome P450 enzyme CYP1B1. Because the genotoxic impact of PAH depends on their metabolism, we hypothesized that high CYP1B1 enzyme levels result in increased formation of PAH-DNA adducts in breast tissue, leading to increased development of breast cancer. We have investigated molecular mechanisms of the relationship between PAH exposure, CYP1B1 expression and breast cancer risk in a clinic-based case-control study. We collected histologically normal breast tissue from 56 women (43 cases and 13 controls) undergoing breast surgery and analyzed these specimens for CYP1B1 genotype, PAH-DNA adducts and CYP1B1 gene expression. We did not detect any difference in aromatic DNA adduct levels of cases and controls, only between smokers and non-smokers. CYP1B1 transcript levels were slightly lower in controls than cases, but the difference was not statistically significant. We found no correlation between the levels of CYP1B1 expression and DNA adducts. If CYP1B1 has any role in breast cancer etiology it might be through its metabolism of estrogen rather than its metabolism of PAHs. However, due to the lack of statistical power these results should be interpreted with caution

472

Case-control study of cancer among Du Pont employees with potential for exposure to dimethylformamide  

Science Conference Proceedings (OSTI)

This case-control study was undertaken to determine whether the risk of developing cancers of the buccal cavity and pharynx (N = 39), liver (N = 6), prostate (N = 43), testis (N = 11), or malignant melanoma of the skin (N = 39) is related to exposure to dimethylformamide (DMF). Case and control subjects were obtained from four Du Pont plants. DMF is produced at one plant and used at the other three. Cancer cases identified from the company Cancer Registry comprise those reported among active male employees at the study plants during 1956 to 1985. For each case, two control subjects were selected, matched on sex, payroll class (wage or salary), birth year, and plant. To determine whether an employee could have been exposed to DMF during his career at the plant, all jobs with potential for exposure to DMF were identified. Each job was assigned an exposure ranking based on DMF industrial hygiene air monitoring, DMF metabolite (measured as N-methylformamide in urine) monitoring, and knowledge of the evolution of manufacturing processes and workplace exposure controls. Each employee's DMF exposure pattern was then characterized as (a) ever v never having been exposed to DMF and (b) highest DMF exposure experienced. Summary analyses for all plants combined showed no statistically significant association between ever having been exposed to DMF and subsequent development of cancers of the buccal cavity and pharynx, liver, malignant melanoma, prostate, and testis. Examined by plant site, prostate cancer at one plant was significantly elevated, based on three case subjects exposed out of four.

Walrath, J.; Fayerweather, W.E.; Gilby, P.G.; Pell, S.

1989-05-01T23:59:59.000Z

473

Recursive Partitioning Analysis for New Classification of Patients With Esophageal Cancer Treated by Chemoradiotherapy  

SciTech Connect

Background: The 7th edition of the American Joint Committee on Cancer staging system does not include lymph node size in the guidelines for staging patients with esophageal cancer. The objectives of this study were to determine the prognostic impact of the maximum metastatic lymph node diameter (ND) on survival and to develop and validate a new staging system for patients with esophageal squamous cell cancer who were treated with definitive chemoradiotherapy (CRT). Methods: Information on 402 patients with esophageal cancer undergoing CRT at two institutions was reviewed. Univariate and multivariate analyses of data from one institution were used to assess the impact of clinical factors on survival, and recursive partitioning analysis was performed to develop the new staging classification. To assess its clinical utility, the new classification was validated using data from the second institution. Results: By multivariate analysis, gender, T, N, and ND stages were independently and significantly associated with survival (p < 0.05). The resulting new staging classification was based on the T and ND. The four new stages led to good separation of survival curves in both the developmental and validation datasets (p < 0.05). Conclusions: Our results showed that lymph node size is a strong independent prognostic factor and that the new staging system, which incorporated lymph node size, provided good prognostic power, and discriminated effectively for patients with esophageal cancer undergoing CRT.

Nomura, Motoo, E-mail: excell@hkg.odn.ne.jp [Department of Radiology, Kansai Medical University, Hirakata (Japan) [Department of Radiology, Kansai Medical University, Hirakata (Japan); Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya (Japan); Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya (Japan); Shitara, Kohei [Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya (Japan)] [Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya (Japan); Kodaira, Takeshi [Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya (Japan)] [Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya (Japan); Kondoh, Chihiro; Takahari, Daisuke; Ura, Takashi [Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya (Japan)] [Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya (Japan); Kojima, Hiroyuki; Kamata, Minoru [Department of Radiology, Kansai Medical University, Hirakata (Japan)] [Department of Radiology, Kansai Medical University, Hirakata (Japan); Muro, Kei [Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya (Japan)] [Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya (Japan); Sawada, Satoshi [Department of Radiology, Kansai Medical University, Hirakata (Japan)] [Department of Radiology, Kansai Medical University, Hirakata (Japan)

2012-11-01T23:59:59.000Z

474

doi:10.1155/2010/953537 Review Article Nanotargeted Radionuclides for Cancer Nuclear Imaging and  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Current progress in nanomedicine has exploited the possibility of designing tumor-targeted nanocarriers being able to deliver radionuclide payloads in a site or molecular selective manner to improve the efficacy and safety of cancer imaging and therapy. Radionuclides of auger electron-, ?-, ?-, and ?-radiation emitters have been surface-bioconjugated or after-loaded in nanoparticles to improve the efficacy and reduce the toxicity of cancer imaging and therapy in preclinical and clinical studies. This article provides a brief overview of current status of applications, advantages, problems, up-to-date research and development, and future prospects of nanotargeted radionuclides in cancer nuclear imaging and radiotherapy. Passive and active nanotargeting delivery of radionuclides with illustrating examples for tumor imaging and therapy are reviewed and summarized. Research on combing different modes of selective delivery of radionuclides through nanocarriers targeted delivery for tumor imaging and therapy offers the new possibility of large increases in cancer diagnostic efficacy and therapeutic index. However, further efforts and challenges in preclinical and clinical efficacy and toxicity studies are required to translate those advanced technologies to the clinical applications for cancer patients. 1.

Internal Radiotherapy; Gann Ting; Chih-hsien Chang; Hsin-ell Wang; Te-wei Lee

2010-01-01T23:59:59.000Z

475

Estimating Cardiac Exposure From Breast Cancer Radiotherapy in Clinical Practice  

SciTech Connect

Purpose: To assess the value of maximum heart distance (MHD) in predicting the dose and biologically effective dose (BED) to the heart and the left anterior descending (LAD) coronary artery for left-tangential breast or chest wall irradiation. Methods and Materials: A total of 50 consecutive breast cancer patients given adjuvant left-tangential irradiation at a large U.K. radiotherapy center during 2006 were selected. For each patient, the following were derived using three-dimensional computed tomography (CT) planning: (1) mean dose and BED to the heart, (2) mean dose and BED to the LAD coronary artery, (3) MHD, (4) position of the CT slice showing the maximum area of the irradiated heart relative to the mid-plane slice, and (5) sternal and contralateral breast thickness (measures of body fat). Results: A strong linear correlation was found between the MHD and the mean heart dose. For every 1-cm increase in MHD, the mean heart dose increased by 2.9% on average (95% confidence interval 2.5-3.3). A strong linear-quadratic relationship was seen between the MHD and the mean heart BED. The mean LAD coronary artery dose and BED were also correlated with the MHD but the associations were weaker. These relationships were not affected by body fat. The mid-plane CT slice did not give a reliable assessment of cardiac irradiation. Conclusion: The MHD is a reliable predictor of the mean heart dose and BED and gives an approximate estimate of the mean LAD coronary artery dose and BED. Doses predicted by the MHD could help assess the risk of radiation-induced cardiac toxicity where individual CT-based cardiac dosimetry is not possible.

Taylor, C.W. [Clinical Trial Service Unit, Oxford (United Kingdom)], E-mail: carolyn.taylor@ctsu.ox.ac.uk; McGale, P. [Clinical Trial Service Unit, Oxford (United Kingdom); Povall, J.M.; Thomas, E.; Kumar, S.; Dodwell, D. [Yorkshire Centre for Clinical Oncology, St. James's Institute of Oncology, St. James's Hospital, Leeds (United Kingdom); Darby, S.C. [Clinical Trial Service Unit, Oxford (United Kingdom)

2009-03-15T23:59:59.000Z

476

IMRT treatment of anal cancer with a scrotal shield  

SciTech Connect

The risk of sterility in males undergoing radiotherapy in the pelvic region indicates the use of a shielding device, which offers protection to the testes for patients wishing to maintain fertility. The use of such devices in the realm of intensity-modulated radiotherapy (IMRT) in the pelvic region can pose many obstacles during simulation, treatment planning, and delivery of radiotherapy. This work focuses on the development and execution of an IMRT plan for the treatment of anal cancer using a scrotal shielding device on a clinical patient. An IMRT plan was developed using Eclipse treatment planning system (Varian Medical Systems, Palo Alto, CA), using a wide array of gantry angles as well as fixed jaw and fluence editing techniques. When possible, the entire target volume was encompassed by the treatment field. When the beam was incident on the scrotal shield, the jaw was fixed to avoid the device and the collimator rotation optimized to irradiate as much of the target as possible. This technique maximizes genital sparing and allows minimal irradiation of the gonads. When this fixed-jaw technique was found to compromise adequate coverage of the target, manual fluence editing techniques were used to avoid the shielding device. Special procedures for simulation, imaging, and treatment verification were also developed. In vivo dosimetry was used to verify and ensure acceptable dose to the gonads. The combination of these techniques resulted in a highly conformal plan that spares organs and risk and avoids the genitals as well as entrance of primary radiation onto the shielding device.

Hood, Rodney C., E-mail: Rodney.Hood@duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Wu, Q. Jackie; McMahon, Ryan; Czito, Brian; Willett, Christopher [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)

2012-01-01T23:59:59.000Z

477

Anti-inflammatory and Cytotoxic Activities of Mango (Mangifera indica L. var Keitt) Polyphenols in Cancer and Non-cancer Breast Fibroblasts in Vitro  

E-Print Network (OSTI)

Breast cancer is the leading cause of cancer death among women worldwide and polyphenols are under investigation as an alternative to conventional treatment approaches of breast cancer. The anti-inflammatory and anti-proliferative activities of polyphenols have been demonstrated in many studies, yet cellular targets and the underlying cellular mechanisms remain unclear. The overall goal of this study was to investigate the anti-inflammatory and cytotoxic properties of polyphenol compounds extracted from the mango variety Keitt in MCF-12A breast non-cancer and MDA-MB231 breast cancer cells by assessing the modulation of signaling pathways involved in inflammation and carcinogenesis. Mango polyphenols were identified by HPLC-MS analysis. The generation of reactive oxygen species was performed using fluorescence intensity in the DCFH-DA assay. Gene expression was analyzed by qRT-PCR, and protein expression was conducted by Western Blotting and Multiplex Bead assay analysis. Bioactive compounds identified in the mango pulp by HPLC-MS included a great variety of polyphenols such as gallic acid, galloyl glucosides with different degree of polymerization and other polyphenols. The anti-inflammatory activities of mango polyphenols were evaluated in MCF-12A non cancer breast fibroblasts. An inflammatory microenvironment for MCF-12A breast cells was induced with tumor necrosis factor alpha (TNF-?). The generation of reactive oxygen species was suppressed significantly compared to cells induced with TNF-?, where there was no significant difference between the concentrations of mango polyphenol extract. Results showed a significant down-regulation of mRNA and protein expression of inflammatory genes involved in the PI3K/AKT pathway and related downstream targets such as NF-?B and mTOR involved in biological processes including cell growth, proliferation and survival. Moreover, mango polyphenols had a significant impact on the miRNA-126-PI3K/AKT axis which plays an important role in inflammation and carcinogenesis, suggesting a potential anti-inflammatory underlying mechanism. The cytotoxic effects of mango polyphenols were investigated in MDA-MB231 breast cancer cells. Mango polyphenols decreased the production of reactive oxygen species; however no significant differences were found between the tested concentrations of mango polyphenols. The gene expression of proapoptotic factors involved in the intrinsic mitochondrial pathway such as cytochrome C and caspase-3 were significantly regulated after mango polyphenol treatment. In addition, the suppression of the PI3K/AKT/mTOR pathway and downstream effectors such as HIF-1? and VEGF as well as the disruption of the miRNA-21-PTEN/AKT axis were identified as potential underlying mechanism of the cytotoxic properties of mango polyphenols. Overall, findings from this study show that mango polyphenols counteract inflammatory and cancerous cell signaling processes; therefore the potential of mango polyphenols in the prevention of breast-cancer focusing on the PI3K/AKT/mTOR-axis should be further investigated.

Arbizu Berrocal, Shirley Heidi

2013-08-01T23:59:59.000Z

478

The Regulation of Multidrug Resistance Phosphoglycoprotein (MDR1/P-gp) and Breast Cancer Resistance Protein (BCRP) in the Human Placenta .  

E-Print Network (OSTI)

??Multidrug resistance phosphoglycoprotein (MDR1/P-gp) and breast cancer resistance protein (BCRP) were first isolated in chemoresistant cancer cells and have since been found in a variety… (more)

Rainey, Jenna

2011-01-01T23:59:59.000Z

479

A Protein that Repairs Damage to Cancer Cells | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

An X-ray Vortex on the Horizon? An X-ray Vortex on the Horizon? How Two Drops Become One Scientists Discover How Nanocluster Contaminants Increase Risk of Spreading Mobile RNA is Poised and Ready Glass Does a Double-Take Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Protein that Repairs Damage to Cancer Cells MAY 5, 2008 Bookmark and Share The ABH2-DNA complex. A team of University of Chicago scientists has shown how two proteins locate and repair damaged genetic material inside cells. Because one of the proteins detects and repairs DNA damage that may result from a certain type of cancer therapy, the researchers raised the possibility of designing a molecule that could interfere with the repair process, making cancer

480

Geek-Up[04.01.2011]: A Discovery to Fight Cancer and Other Diseases |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4.01.2011]: A Discovery to Fight Cancer and Other Diseases 4.01.2011]: A Discovery to Fight Cancer and Other Diseases Geek-Up[04.01.2011]: A Discovery to Fight Cancer and Other Diseases April 1, 2011 - 5:52pm Addthis Two structures of the Mre11-Rad50 complex were solved independently and overlaid, further revealing a flexible hinge in Rad50 near the Mre11 binding site | Courtesy of Lawrence Berkeley National Laboratory Two structures of the Mre11-Rad50 complex were solved independently and overlaid, further revealing a flexible hinge in Rad50 near the Mre11 binding site | Courtesy of Lawrence Berkeley National Laboratory Niketa Kumar Niketa Kumar Public Affairs Specialist, Office of Public Affairs What does this mean for me? Researchers discovered that a cell's speedy ability to repair damaged DNA relies on the remarkable flexibility of a molecular motor.

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481

Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones  

SciTech Connect

The changes in tissue architecture that accompany the development of breast cancer have been the focus of investigations aimed at developing new cancer therapeutics. As we learn more about the normal mammary gland, we have begun to understand the complex signaling pathways underlying the dramatic shifts in the structure and function of breast tissue. Integrin-, growth factor-, and steroid hormone-signaling pathways all play an important part in maintaining tissue architecture; disruption of the delicate balance of signaling results in dramatic changes in the way cells interact with each other and with the extracellular matrix, leading to breast cancer. The extracellular matrix itself plays a central role in coordinating these signaling processes. In this review, we consider the interrelationships between the extracellular matrix, integrins, growth factors, and steroid hormones in mammary gland development and function.

Hansen, R K; Bissell, M J

2000-06-01T23:59:59.000Z

482

The ACGT Master Ontology and its applications - Towards an ontology-driven cancer research and management system  

Science Conference Proceedings (OSTI)

Objective: This paper introduces the objectives, methods and results of ontology development in the EU co-funded project Advancing Clinico-genomic Trials on Cancer - Open Grid Services for Improving Medical Knowledge Discovery (ACGT). While the available ... Keywords: Cancer research, Clinical trial administration, Ontological engineering, Ontology, Translational medicine

Mathias Brochhausen; Andrew D. Spear; Cristian Cocos; Gabriele Weiler; Luis Martín; Alberto Anguita; Holger Stenzhorn; Evangelia Daskalaki; Fatima Schera; Ulf Schwarz; Stelios Sfakianakis; Stephan Kiefer; Martin Dörr; Norbert Graf; Manolis Tsiknakis

2011-02-01T23:59:59.000Z

483

Using support vector regression to model the correlation between the clinical metastases time and gene expression profile for breast cancer  

Science Conference Proceedings (OSTI)

Objective: Recently, the microarray analysis has been an important tool used for studying the cancer type, biological mechanism, and diagnostic biomarkers. There are several machine-learning methods being used to construct the prognostic model based ... Keywords: Breast cancer, Feature selection, Metastases time, Microarray, Support vector regression

Shih-Hau Chiu; Chien-Chi Chen; Thy-Hou Lin

2008-11-01T23:59:59.000Z

484

Meta-analysis of Genomic and Proteomic Features to Predict Synthetic Lethality of Yeast and Human Cancer  

Science Conference Proceedings (OSTI)

A major goal in cancer medicine is to find selective drugs with reduced side-effect. A pair of genes is called synthetic lethality (SL) if mutations of both genes will kill a cell while mutation of either gene alone will not. Hence, a gene in SL interactions ... Keywords: Cancer, Classification, Comparative genomics, Meta-analysis, Synthetic lethality, TCGA

Min Wu, Xuejuan Li, Fan Zhang, Xiaoli Li, Chee-Keong Kwoh, Jie Zheng

2013-09-01T23:59:59.000Z

485

MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform  

SciTech Connect

Optimizing the treatment of breast cancer remains a major topic of interest. In current clinical practice, breast-conserving therapy is the standard of care for patients with localized breast cancer. Technological developments have fueled interest in less invasive breast cancer treatment. Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a completely noninvasive ablation technique. Focused beams of ultrasound are used for ablation of the target lesion without disrupting the skin and subcutaneous tissues in the beam path. MRI is an excellent imaging method for tumor targeting, treatment monitoring, and evaluation of treatment results. The combination of HIFU and MR imaging offers an opportunity for image-guided ablation of breast cancer. Previous studies of MR-HIFU in breast cancer patients reported a limited efficacy, which hampered the clinical translation of this technique. These prior studies were performed without an MR-HIFU system specifically developed for breast cancer treatment. In this article, a novel and dedicated MR-HIFU breast platform is presented. This system has been designed for safe and effective MR-HIFU ablation of breast cancer. Furthermore, both clinical and technical challenges are discussed, which have to be solved before MR-HIFU ablation of breast cancer can be implemented in routine clinical practice.

Merckel, Laura G., E-mail: L.G.Merckel-2@umcutrecht.nl [University Medical Center Utrecht, Department of Radiology (Netherlands); Bartels, Lambertus W., E-mail: W.Bartels@umcutrecht.nl [University Medical Center Utrecht, Image Sciences Institute (Netherlands); Koehler, Max O., E-mail: max.kohler@philips.com [Philips Healthcare (Finland); Bongard, H. J. G. Desiree van den, E-mail: D.vandenBongard@umcutrecht.nl [University Medical Center Utrecht, Department of Radiotherapy (Netherlands); Deckers, Roel, E-mail: R.Deckers-2@umcutrecht.nl [University Medical Center Utrecht, Image Sciences Institute (Netherlands)] [University Medical Center Utrecht, Image Sciences Institute (Netherlands); Mali, Willem P. Th. M., E-mail: W.Mali@umcutrecht.nl [University Medical Center Utrecht, Department of Radiology (Netherlands); Binkert, Christoph A., E-mail: Christoph.Binkert@ksw.ch [Cantonal Hospital Winterthur, Department of Radiology (Switzerland); Moonen, Chrit T., E-mail: C.Moonen@umcutrecht.nl [University Medical Center Utrecht, Image Sciences Institute (Netherlands); Gilhuijs, Kenneth G. A., E-mail: K.G.A.Gilhuijs@umcutrecht.nl; Bosch, Maurice A. A. J. van den, E-mail: mbosch@umcutrecht.nl [University Medical Center Utrecht, Department of Radiology (Netherlands)

2013-04-15T23:59:59.000Z

486

doi:10.1155/2012/373879 Review Article On the RET Rearrangements in Chernobyl-Related Thyroid Cancer  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. There is a consensus that Chernobyl accident has induced thyroid cancer increase in children and adolescents. The UNSCEAR report concluded that no somatic disorders other than thyroid cancer were caused by radiation exposure due to the accident except for acute radiation sickness occurred to the people within the Power Plant at the time of the accident. A hypothesis is discussed in this paper that the increase of thyroid cancer was caused predominantly by the screening, overdiagnosis, and registration of nonirradiated persons as Chernobyl victims. A mechanism of thyroid cancer overdiagnosis is described that can be active even today, causing hypertherapy. Older neglected tumors found by the screening shortly after the Chernobyl accident or brought from noncontaminated areas were misclassified as aggressive radiation-induced cancers. Therefore, supposed markers of the radiationinduced thyroid cancer, such as the RET rearrangements, are p