Sample records for latent cancer fatalities

  1. Aneuploidy: Cancer's Fatal Flaw?

    E-Print Network [OSTI]

    Williams, Bret R.

    Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we ...

  2. Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis

    E-Print Network [OSTI]

    Gerry, Arianna Aldridge

    2011-01-01T23:59:59.000Z

    minority adolescents: A latent profile analysis. Journal ofKeane, S. P. (2006). Profiles of externalizing behaviorMarch). Developing coping profiles of minority adolescents:

  3. Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis

    E-Print Network [OSTI]

    Gerry, Arianna Aldridge

    2011-01-01T23:59:59.000Z

    1998). Reducing cervical cancer among First Nations women.K. , & Edwards, B.K. (2002). Cancer survival among US whitestreatment of primary breast cancer: A systematic review.

  4. Monitoring bat and bird fatalities at the Casselman Wind Energy...

    Energy Savers [EERE]

    Monitoring bat and bird fatalities at the Casselman Wind Energy Center in Pennsylvania Monitoring bat and bird fatalities at the Casselman Wind Energy Center in Pennsylvania...

  5. Investigation of the September 13, 2011, Fatality at the Strategic...

    Energy Savers [EERE]

    September 13, 2011, Fatality at the Strategic Petroleum Reserve Bryan Mound Site Investigation of the September 13, 2011, Fatality at the Strategic Petroleum Reserve Bryan Mound...

  6. Accident Investigation of the September 20, 2012 Fatal Fall from...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    September 20, 2012 Fatal Fall from the Dworshak-Taft 1 Transmission Tower, at the Bonneville Power Marketing Administration Accident Investigation of the September 20, 2012 Fatal...

  7. Oestrogen metabolism and action in epithelial ovarian cancer 

    E-Print Network [OSTI]

    Ren, Xia

    2011-11-25T23:59:59.000Z

    Ovarian cancer is the most fatal of all gynecological malignancies. Epithelial ovarian cancer (EOC) accounts for about 90% of malignant ovarian tumours and is thought to originate mostly from ovarian surface epithelium ...

  8. autoinmune latente del: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    We describe algorithms for estimating binary latent known, understood, and used tool, multivariate nor- mal distributions, not always applicable Kirshner, Sergey 9 Latent heat...

  9. Fatal injuries among Hispanic construction workers

    E-Print Network [OSTI]

    Bryson, Elizabeth Anne

    2003-01-01T23:59:59.000Z

    in the population of these trades were not perlormed. Fabrega and Starkey noted that Hispanics were underreprcsented in some of the higher-skilled trades, such as electricians, carpenters, and supervisors. OSHA (2002) has also become concerned about the fatality... trade, such ius plumber or electrician. On the other hand, 23% of the whites in the study were employed in a basic trade, while 29'7a were in a mechanical trade (Anderson and Hunting, 2000). Also, few Hispanics were members of a union, which can...

  10. Accident Investigation of the July 30, 2013, Electrical Fatality...

    Energy Savers [EERE]

    to the Secretary of Labor Accident Investigation of the September 20, 2012 Fatal Fall from the Dworshak-Taft 1 Transmission Tower, at the Bonneville Power Marketing Administration...

  11. A Latent Time-Budget Model

    E-Print Network [OSTI]

    Jan de Leeuw; Peter G.M. van der Heijden; Peter Verboon

    2011-01-01T23:59:59.000Z

    DE L E E U W (1989), Latent budget analysis, in: A. DECARLI,DER H E U D E N (1988), The analysis of time- budgets with alatent-time-budget model, in E. Diday et al. (eds. ), Data

  12. GM Project G.6 October 20008 -1 8. FATAL CRASH RATES

    E-Print Network [OSTI]

    GM Project G.6 October 20008 - 1 8. FATAL CRASH RATES 8.1 MODELING FATALITY RATES FOR OLDER DRIVERS crash rate concepts we call "driver risk,"or the driver fatality rate. It is the fatality rate, per mile driver. The driver fatality risk rate is measured by dividing the number of older drivers in a given age

  13. Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis

    E-Print Network [OSTI]

    Jackson, Erica L. (Erica Lynn), 1973-

    2003-01-01T23:59:59.000Z

    Lung cancer is the leading cause of cancer deaths worldwide. Patients are typically diagnosed with advanced disease and have a high fatality:case ratio. Despite its prevalence, the identity of the cell of origin, precursor ...

  14. Type A Accident Report of the June 26, 2009 Vehicle Fatality...

    Broader source: Energy.gov (indexed) [DOE]

    the June 26, 2009 Vehicle Fatality at Lawrence Livermore National Laboratory Type A Accident Report of the June 26, 2009 Vehicle Fatality at Lawrence Livermore National...

  15. apple latent spherical: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regarding Jones, Peter JS 102 Brain morphometry by probabilistic Latent Semantic Analysis Computer Technologies and Information Sciences Websites Summary: Brain morphometry by...

  16. BIRD FATALITY ASSOCIATIONS AND PREDICTIVE MODELS FOR THE APWRA

    E-Print Network [OSTI]

    kill birds or that the type of tower or wind turbine does not relate to bird mortality (Anderson et al on wind turbines with tubular towers, and Thelander and Rugge (2001) found that mortality was no less A major step toward reducing bird fatalities at wind energy generating facilities will be to identify

  17. Level 1 Accident Report of the March 1, 2010 Bobcat Fatality...

    Broader source: Energy.gov (indexed) [DOE]

    Report of the March 1, 2010 Bobcat Fatality at BPA's White Bluffs Substation Level 1 Accident Report of the March 1, 2010 Bobcat Fatality at BPA's White Bluffs Substation March 31,...

  18. Segmentation and Enhancement of Latent Fingerprints: A Coarse to Fine Ridge

    E-Print Network [OSTI]

    a latent fingerprint image, a total variation (TV) decomposition model with L1 fidelity regularization INTRODUCTION LATENT fingerprints (or simply latents or finger marks) refer to fingerprints lifted from the sur

  19. Adding Domain Knowledge to Latent Topic Models Xiaojin Zhu

    E-Print Network [OSTI]

    Zhu, Xiaojin "Jerry"

    (Wisconsin) Knowledge LDA 5 / 42 #12;Some Topics by Latent Dirichlet Allocation (LDA) [Blei et al., JMLR by Latent Dirichlet Allocation (LDA) [Blei et al., JMLR 2003] p(word | topic) "troops" "election" "love influence [Gerrish & Blei, 2009] Matching papers to reviewers [Mimno & McCallum, 2007] Zhu (Wisconsin

  20. Relationship of Self-Rated Health with Fatal and Non-Fatal Outcomes in Cardiovascular Disease: A Systematic Review and Meta-Analysis

    E-Print Network [OSTI]

    Mavaddat, Nahal; Parker, Richard A.; Sanderson, Simon; Mant, Jonathan; Kinmonth, Ann Louise

    2014-07-30T23:59:59.000Z

    , and hazard ratio was greatly reduced if the van der Linde study was omitted (table 3). 3. Combined fatal and non-fatal CVD events. Figure 5 shows the results of a meta-analysis of hazard ratios of poor health relative to excellent health for combined fatal... and non-fatal CVD events from studies of unselected populations. The combined summary estimate for the hazard ratio was 1.90 (95% CI 1.26 to 2.87). The I2-statistic was 68.61%, falling to 0% without loss of significance after excluding van der Linde (2013...

  1. Physical model for the latent heat of fusion

    E-Print Network [OSTI]

    Jozsef Garai

    2004-11-06T23:59:59.000Z

    The atomic movement induced on melting has to overcome a viscous drag resistance. It is suggested that the latent heat of fusion supplies the required energy for this physical process. The viscosity model introduced here allows computation of the latent heat from viscosity, molar volume, melting temperature, and atomic mass and diameter. The correlation between these parameters and the latent heat of 14 elements with body and face centered cubic structures was exceptional, with the correlation coefficients of 0.97 and 0.95 respectively.

  2. Multi-Label Informed Latent Semantic Indexing , Shipeng Yu

    E-Print Network [OSTI]

    Tresp, Volker

    Multi-Label Informed Latent Semantic Indexing Kai Yu , Shipeng Yu , Volker Tresp Siemens AG, University of Munich, Germany kai.yu@siemens.com, volker.tresp@siemens.com, spyu

  3. The latent effect of cogency in the minority influence process

    E-Print Network [OSTI]

    Ouellette, Judith A

    1993-01-01T23:59:59.000Z

    THE LATENT EFFECT OF COGENCY IN THE MINORITY INFLUENCE PROCESS A Thesis by JUDITH ANN OUELLETTE Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1993 Major subject: Psychology THE LATENT EFFECT OF COGENCY IN THE MINORITY INFLUENCE PROCESS A Thesis by JUDITH ANN OUELLETTE Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment...

  4. A research university's rapid response to a fatal chemistry accident: Safety changes and outcomes

    E-Print Network [OSTI]

    Gibson, JH; Schröder, I; Wayne, NL

    2014-01-01T23:59:59.000Z

    to a fatal chemistry accident: Safety changes and outcomesprogram following a chemistry accident in December 2008 thatcommunity. Since the 2008 accident at UCLA, the na- tional

  5. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    Not Available

    1999-01-01T23:59:59.000Z

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  6. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    NONE

    1999-11-01T23:59:59.000Z

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  7. accident-related fatal injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    using intelligent data analysis of admission variables and time series physiological brain damage in a series of 151 fatal cases of severe head injury subjected to autopsy....

  8. Independent Review of the July 8, 2010 Fatality at the Strategic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Independent Review of the July 8, 2010 Fatality at the Strategic Petroleum Reserve Bryan Mound Site - May 25, 2011 Addendum closing the Investigation based upon the Galveston...

  9. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer

    E-Print Network [OSTI]

    Paxton, Anthony T.

    --22000000 58 Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer

  10. Microsoft Word - fact sheet alternatives and key findings 090214...

    National Nuclear Security Administration (NNSA)

    health of workers and the public. Worker dose would result in additional latent cancer fatality risk of a maximum of 1 chance in 100,000. Public dose would result in...

  11. Heat-transfer coefficients in agitated vessels. Latent heat models

    SciTech Connect (OSTI)

    Kumpinsky, E. [Ashland Chemical Co., Columbus, OH (United States)] [Ashland Chemical Co., Columbus, OH (United States)

    1996-03-01T23:59:59.000Z

    Latent heat models were developed to calculate heat-transfer coefficients in agitated vessels for two cases: (1) heating with a condensable fluid flowing through coils and jackets; (2) vacuum reflux cooling with an overhead condenser. In either case the mathematical treatment, based on macroscopic balances, requires no iterative schemes. In addition to providing heat-transfer coefficients, the models predict flow rates of service fluid through the coils and jackets, estimate the percentage of heat transfer due to latent heat, and compute reflux rates.

  12. Botryosphaeriaceae as endophytes and latent pathogens of woody plants: diversity, ecology and impact

    E-Print Network [OSTI]

    Review Botryosphaeriaceae as endophytes and latent pathogens of woody plants: diversity, ecology Keywords: Botryosphaeria Botryosphaeriaceae Emerging tree diseases Endophyte Latent pathogen Quarantine to general patterns observed for the collective of endophytes of woody plants. These include high levels

  13. Quantification of latent travel demand on new urban facilities in the state of Texas

    E-Print Network [OSTI]

    Henk, Russell H

    1989-01-01T23:59:59.000Z

    transportation facility was opened for use. The comparison of the photographs allowed for any changes in land use to be easily recognized. 15 Preliminar Anal sis of Variables Identification of Latent Travel Oemand The first step in this analysis of latent... facilities (3). Therefore, this highway characteristic was also included as a possible latent demand indicator. Detailed Anal sis of Variables In order to examine their relationships with latent travel demand on new urban transportation facilities...

  14. The association between fatalistic beliefs and late stage at diagnosis of lung and colorectal cancer

    E-Print Network [OSTI]

    Lyratzopoulos, Georgios; Liu, Michael Pang-Hsiang; Abel, Gary A.; Wardle, Jane; Keating, Nancy L.

    2015-02-03T23:59:59.000Z

    -based cohort of 4,319 U.S. patients with newly-diagnosed lung or colorectal cancer participating in the Cancer Care Outcomes and Research Surveillance (CanCORS) study. Fatalistic beliefs were assessed with an established measure. A fatalism score (range 4...

  15. Latent-Descriptor Clustering for Unsupervised POS Induction Michael Lamar

    E-Print Network [OSTI]

    Bienenstock, Elie

    Latent-Descriptor Clustering for Unsupervised POS Induction Michael Lamar Department of Mathematics; Lamar et al., 2010; Reichart et al., 2010; Berg-Kirkpatrick et al., 2010). Some of these methods use papers advocate non- disambiguating models (Abend et al., 2010; Lamar et al., 2010): these assign

  16. Complexity of Inference in Latent Dirichlet David Sontag

    E-Print Network [OSTI]

    , document summarization, and classification [Blei and McAuliffe, 2008; Lacoste-Julien et al., 2009 of the simplest and most popular models, Latent Dirichlet Allocation (LDA) [Blei et al., 2003]. The LDA model on approximate inference algorithms for topic mod- els, such Gibbs sampling and variational inference [Blei et al

  17. Latent extinction risk and the future battlegrounds of mammal conservation

    E-Print Network [OSTI]

    Wilmers, Chris

    or where many species are thought to be at imminent risk of extinction. However, these strategies may identify such areas for the world's mammals using latent extinction risk, the discrepancy between a species' current extinction risk and that predicted from models on the basis of biological traits. Species

  18. Relationship between gradient and EM steps in latent variable models.

    E-Print Network [OSTI]

    Roweis, Sam

    includes random search, standard gradient­based algorithms, line search methods such as conjugate gradient to to first order method operat­ ing on the gradient of a locally reshaped likelihood function. DirectRelationship between gradient and EM steps in latent variable models. Ruslan Salakhutdinov Sam

  19. Relationship between gradient and EM steps in latent variable models.

    E-Print Network [OSTI]

    Roweis, Sam

    includes random search, standard gradient-based algorithms, line search methods such as conjugate gradient to to first order method operat- ing on the gradient of a locally reshaped likelihood function. DirectRelationship between gradient and EM steps in latent variable models. Ruslan Salakhutdinov Sam

  20. CFTB 04/22/2010 Revisions to the 2008 Census of Fatal Occupational...

    National Nuclear Security Administration (NNSA)

    Injuries (CFOI) counts The final count of fatal work injuries in the U.S. in 2008 was 5,214, up from the preliminary count of 5,071 reported in August 2009. The final 2008...

  1. Do-Not-Resuscitate Orders in Fatal Toxic Exposures: A Poison Center’s Review

    E-Print Network [OSTI]

    Weerasuriya, Dilani; Sheikh, Sophia; Morgan, Brent W

    2012-01-01T23:59:59.000Z

    in Fatal Toxic Exposures: A Poison Center’s Review DilaniAtlanta, Georgia Georgia Poison Control, Atlanta, GeorgiaISE) patient using the Regional Poison Control Center (RPCC)

  2. Independent Control of Sensible and Latent Cooling in Small Buildings

    E-Print Network [OSTI]

    Andrews, J.; Lamontagne, J.; Piraino, M.

    1989-01-01T23:59:59.000Z

    ABSTRACT INDEPENDENT CONTROL OF SENSIBLE AND LATENT COOLING IN SMALL BUILDINGS~ J. ANDREWS, J. LAMONTAGNE, and M. PIRAINO Brookhaven National Laboratory Upton, New York This paper presents salient results of a utility-sponsored research project... characteristics used in the study are those found in a study of an energy- efficient Danish house which was constructed and monitored at Brookhaven National Laboratory (7). This house was found to have a natural air change rate of 0.1 air changes per hour...

  3. Bayesian latent variable modelling in studies of air pollution and health

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    Bayesian latent variable modelling in studies of air pollution and health Duncan Lee, Gavin://www.bath.ac.uk/math-sci/BICS #12;Bayesian latent variable modelling in studies of air pollution and health. Duncan Lee (1), Gavin to air pollution on respiratory mortality in the elderly (aged 65 and above) in London, England, between

  4. A Framework for Incorporating General Domain Knowledge into Latent Dirichlet Allocation using First-Order Logic

    E-Print Network [OSTI]

    Zhu, Xiaojin "Jerry"

    of Latent Dirichlet Allocation (LDA) [Blei et al., 2003], a large number of latent-topic- model variants- rating external knowledge specific to the target domain, see e.g., [Wang et al., 2009; Gerrish and Blei research, too. 2 The Fold·all Framework We now briefly review the standard LDA model [Blei et al., 2003

  5. Clustering Educational Digital Library Usage Data: A Comparison of Latent Class Analysis and

    E-Print Network [OSTI]

    Qi, Xiaojun

    Clustering Educational Digital Library Usage Data: A Comparison of Latent Class Analysis and K-Means Analysis is superior to K-means on all three comparisons. In particular, LCA is more immune to the variance, the widely used K-means and the model-based Latent Class Analysis, are compared, using usage data from

  6. An Investigation of the Latent Semantic Analysis Technique for Document Retrieval

    E-Print Network [OSTI]

    An Investigation of the Latent Semantic Analysis Technique for Document Retrieval STUDENT PROJECT;_________________________________________________________________________ An Investigation of the Latent Semantic Analysis Technique for Document Retrieval. Report by: David Mugo Page 2. These term-matching techniques have always relied on matching query terms with document terms to retrieve

  7. An investigation into the thermal properties of selected sensible and latent heat storage materials 

    E-Print Network [OSTI]

    Wood, Stanley Clayton

    1982-01-01T23:59:59.000Z

    in the latent heat of fusion. Considerable work has been done in analyzing latent heat storage systems. Telkes and Raymond [lj did early work with a sodium sulfate system using sealed drums. iVore recent experimental work was conducted with other salt...

  8. An investigation into the thermal properties of selected sensible and latent heat storage materials

    E-Print Network [OSTI]

    Wood, Stanley Clayton

    1982-01-01T23:59:59.000Z

    in the latent heat of fusion. Considerable work has been done in analyzing latent heat storage systems. Telkes and Raymond [lj did early work with a sodium sulfate system using sealed drums. iVore recent experimental work was conducted with other salt...

  9. Latent Learning in Deep Neural Nets Steven Gutstein, Olac Fuentes and Eric Freudenthal

    E-Print Network [OSTI]

    Fuentes, Olac

    Latent Learning in Deep Neural Nets Steven Gutstein, Olac Fuentes and Eric Freudenthal Abstract of transfer learning. We utilize latent learning to enable a deep neural net to dis- tinguish among a set-mean' classification technique, which is explained later in this paper. The deep neural net architecture used was a Le

  10. Global patterns of landatmosphere fluxes of carbon dioxide, latent heat, and sensible heat derived from eddy covariance,

    E-Print Network [OSTI]

    Chen, Jiquan

    (NEE), latent energy (LE), and sensible heat (H) based on remote sensing indices, climateGlobal patterns of landatmosphere fluxes of carbon dioxide, latent heat, and sensible heat derived

  11. Motor Vehicle Crash Fatalities and Injuries: An Analysis of the Relationship of Roadway, Driver, Vehicle Characteristics in Oregon

    E-Print Network [OSTI]

    Bertini, Robert L.

    Motor Vehicle Crash Fatalities and Injuries: An Analysis of the Relationship of Roadway, Driver, Vehicle Characteristics in Oregon Motor Vehicle Crash Fatalities and Injuries: An Analysis,000 population among Oregon counties from 2000-2005 ranged from 6.64-211.17. In the event of a severe motor

  12. Case Report Fatal Ophiostoma piceae infection in a patient with acute lymphoblastic leukaemia

    E-Print Network [OSTI]

    , chemotherapy was initiated according to the German Acute Lymphoblastic Leukemia study group (GMALL 07Case Report Fatal Ophiostoma piceae infection in a patient with acute lymphoblastic leukaemia-related fungus caused disseminated infection involving the lung and the brain in a patient with lymphoblastic

  13. Actuarial risk assessment of expected fatalities attributable to carbon capture and storage in 2050

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Actuarial risk assessment of expected fatalities attributable to carbon capture and storage : 10.1016/j.ijggc.2011.07.004 #12;2 1. Introduction Carbon capture and storage (CCS) involves capturing of carbon and the cost of capture. From the engineering, psychological or climatic point of view, one

  14. Actuarial risk assessment of expected fatalities attributable to carbon capture and storage in 2050

    E-Print Network [OSTI]

    Actuarial risk assessment of expected fatalities attributable to carbon capture and storage in 2050-00487175,version2-10Feb2011 #12;1. Introduction Carbon capture and storage (CCS) involves capturing the CO2 is assessed integrating all steps of the CCS chain: additional coal production, coal transportation, carbon

  15. PAVEMENT PREDICTION PERFORMANCE MODELS AND RELATION WITH TRAFFIC FATALITIES AND INJURIES

    E-Print Network [OSTI]

    Boyer, Edmond

    PAVEMENT PREDICTION PERFORMANCE MODELS AND RELATION WITH TRAFFIC FATALITIES AND INJURIES V. CEREZO.gothie@developpement-durable.gouv.fr ABSTRACT This paper presents some results of a study, which aimed at modelling pavement evolution, pavement characteristics and age. In a second part, non-linear regressions were used in view of obtaining

  16. Formation of nanometer-size wires using infiltration into latent nuclear tracks

    DOE Patents [OSTI]

    Musket, Ronald G. (Danville, CA); Felter, Thomas E. (Livermore, CA)

    2002-01-01T23:59:59.000Z

    Nanometer-size wires having a cross-sectional dimension of less than 8 nm with controllable lengths and diameters are produced by infiltrating latent nuclear or ion tracks formed in trackable materials with atomic species. The trackable materials and atomic species are essentially insoluble in each other, thus the wires are formed by thermally driven, self-assembly of the atomic species during annealing, or re-crystallization, of the damage in the latent tracks. Unlike conventional ion track lithography, the inventive method does not require etching of the latent tracks.

  17. Polarity Inducing Latent Semantic Analysis Wen-tau Yih Geoffrey Zweig John C. Platt

    E-Print Network [OSTI]

    Hunt, Galen

    Polarity Inducing Latent Semantic Analysis Wen-tau Yih Geoffrey Zweig John C. Platt Microsoft) and cross-lingual docu- ment retrieval (Platt et al., 2010). At the word level, vector representations have

  18. A Latent Mixed Membership Model for Relational Data Edoardo Airoldi, David Blei, Eric Xing

    E-Print Network [OSTI]

    Murphy, Robert F.

    A Latent Mixed Membership Model for Relational Data Edoardo Airoldi, David Blei, Eric Xing School of Computer Science Carnegie Mellon University {eairoldi,blei,xing}@cs.cmu.edu Stephen Fienberg Department

  19. A model for the latent heat of melting in free standing metal nanoparticles

    SciTech Connect (OSTI)

    Shin, Jeong-Heon; Deinert, Mark R., E-mail: mdeinert@mail.utexas.edu [Department of Mechanical Engineering, The University of Texas at Austin, Austin, Texas 78715 (United States)

    2014-04-28T23:59:59.000Z

    Nanoparticles of many metals are known to exhibit scale dependent latent heats of melting. Analytical models for this phenomenon have so far failed to completely capture the observed phenomena. Here we present a thermodynamic analysis for the melting of metal nanoparticles in terms of their internal energy and a scale dependent surface tension proposed by Tolman. The resulting model predicts the scale dependence of the latent heat of melting and is confirmed using published data for tin and aluminum.

  20. Analysis of non-fatal and fatal injury rates for mine operator and contractor employees and the influence of work location

    SciTech Connect (OSTI)

    Karra, V.K. [NIOSH, Pittsburgh, PA (United States). Pittsburgh Research Laboratory

    2005-07-01T23:59:59.000Z

    Mining injury surveillance data are used as the basis for assessing the severity of injuries among operator and contractor employees in the underground and surface mining of various minerals. Injury rates during 1983-2002 derived from Mine Safety and Health Administration (MSHA) database are analyzed using the negative binomial regression model. The logarithmic mean injury rate is expressed as a linear function of seven indicator variables representing Non-Coal Contractor, Metal Operator, Non Metal Operator, Stone Operator, Sand and Gravel Operator, Coal Contractor, and Work Location, and a continuous variable, RelYear, representing the relative year starting, with 1983 as the base year. Based on the model, the mean injury rate declined at a 1.69% annual rate, and the mean injury rate for work on the Surface is 52.53% lower compared to the title for work in the underground. With reference to the Coal Operator mean injury rate: the Non-Coal Contractor rate is 30.34% lower, the Metal Operator rate is 27.18% lower, the Non-Metal Operator rate is 37.51% lower, the Stone Operator rate is 23.44% lower, the Sand and Gravel Operator rate is 16.45% lower, and the Coal Contractor rate is 1.41% lower. Fatality rates during the same 20 year period are analyzed similarly using Poisson regression model. Based on this model, the mean fatality rate declined at a 3.17% annual rate, and the rate for work on the surface is 64.3% lower compared to the rate for work in the underground. With reference to the Coal Operator mean fatality rate: the Non-Coal Coil tractor rate is 234.81% higher, the Metal Operator rate is 5.79% lower, the Non-Metal Operator rate is 47.36% lower, the Stone Operator rate is 8.29% higher, the Sand and Gravel Operator rate is 60.32% higher, and the Coal Contractor rate is 129.54% higher.

  1. Enhancing multilingual latent semantic analysis with term alignment information.

    SciTech Connect (OSTI)

    Chew, Peter A.; Bader, Brett William

    2008-08-01T23:59:59.000Z

    Latent Semantic Analysis (LSA) is based on the Singular Value Decomposition (SVD) of a term-by-document matrix for identifying relationships among terms and documents from co-occurrence patterns. Among the multiple ways of computing the SVD of a rectangular matrix X, one approach is to compute the eigenvalue decomposition (EVD) of a square 2 x 2 composite matrix consisting of four blocks with X and XT in the off-diagonal blocks and zero matrices in the diagonal blocks. We point out that significant value can be added to LSA by filling in some of the values in the diagonal blocks (corresponding to explicit term-to-term or document-to-document associations) and computing a term-by-concept matrix from the EVD. For the case of multilingual LSA, we incorporate information on cross-language term alignments of the same sort used in Statistical Machine Translation (SMT). Since all elements of the proposed EVD-based approach can rely entirely on lexical statistics, hardly any price is paid for the improved empirical results. In particular, the approach, like LSA or SMT, can still be generalized to virtually any language(s); computation of the EVD takes similar resources to that of the SVD since all the blocks are sparse; and the results of EVD are just as economical as those of SVD.

  2. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Lung cancer Lung cancer Lung cancer Lung c

    E-Print Network [OSTI]

    Paxton, Anthony T.

    --22000000 34 Lung cancer Lung cancer Lung cancer Lung c ancer Lung cancer Lung cancer Lung cancer L ung cancer Lung cancer Lung cancer Lung can cer Lung cancer Lung cancer Lung cancer Lun g cancer Lung cancer Lung cancer Lung cance r Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer

  3. LUNG CANCER 6. LUNG CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    LUNG CANCER 47 6. LUNG CANCER 6.1. SUMMARY Lung cancer was the third most common cancer in Ireland (Table 6.1). The average number of new lung cancer cases diagnosed each year was 1,000 in women and 1 for women and 1% for men. The risk of developing lung cancer up to the age of 74 was 1 in 37 for women and 1

  4. Reducing Bat Fatalities From Interactions with Operating Wind Turbines (Fact Sheet)

    SciTech Connect (OSTI)

    Lawson, M.

    2013-11-01T23:59:59.000Z

    One of the biggest advantages of wind energy is that, overall, it has fewer negative impacts on the environment than fossil fuel-generated energy. Most professionals in the wind industry would like to reduce the impact of energy generation on plants, animals, and their habitats. This is why the industry is highly motivated to find out why migrating bats have unexpectedly high fatality rates near operating wind farms. New research has provided quantitative data that indicates barotrauma is not a major cause of bat deaths around operating turbines.

  5. Report on a Fatal Accident and Fire at the West London Terminal of Esso Petroleum Company Limited on 1st April, 1967 

    E-Print Network [OSTI]

    Black, H. K.

    1968-01-01T23:59:59.000Z

    A12.P46 Report on a Fatal Accident and Fire at the West London Terminal of Esso Petroleum Company Limited on 1st April, 1967...

  6. Radiation Exposure to Patient and Staff in Hepatic Chemoembolization: Risk Estimation of Cancer and Deterministic Effects

    SciTech Connect (OSTI)

    Hidajat, Nico, E-mail: nico.hidajat@gmx.de; Wust, Peter; Felix, Roland; Schroeder, Ralf Juergen [Charite Campus Virchow-Klinikum, Humboldt-University of Berlin, Department of Radiology (Germany)

    2006-10-15T23:59:59.000Z

    The purpose of the study was to determine the risks of radiation-induced cancer and deterministic effects for the patient and staff in transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). Sixty-five patients with HCC underwent the first cycle of TACE. Thermoluminescence dosemeters and conversion factors were used to measure surface doses and to calculate organ doses and effective dose. For the patient, the risk of fatal cancer and severe genetic defect was in the magnitude of 10{sup -4} and 10{sup -5}, respectively. Five patients showed surface doses over the first lumbar vertebra exceeding 2000 mSv and 45 patients showed doses over the spine or the liver region above 500 mSv. The risk of fatal cancer and severe genetic defect for the radiologist and assistant was in the magnitude of 10{sup -7} to 10{sup -8}. They could exceed the threshold for lens opacity in the case of more than 490 and 1613 TACE yearly for a period of many years, respectively. Radiation dose could lead to local transient erythema and/or local depression of hematopoiesis in many patients after TACE. For the radiologist and assistant, risk of fatal cancer and genetic defect and lens opacity might arise when they perform interventions such as TACE intensively.

  7. Longitudinal variation of tides in the MLT region: 2. Relative effects of solar radiative and latent heating

    E-Print Network [OSTI]

    Forbes, Jeffrey

    of solar radiative and latent heating Xiaoli Zhang,1 Jeffrey M. Forbes,1 and Maura E. Hagan2 Received 11 study examines the relative importance of radiative heating and latent heating in accounting (GSWM) and new tidal heating rates derived from International Satellite Cloud Climatology Project (ISCCP

  8. A. Gershunov R. Roca Coupling of latent heat flux and the greenhouse effect by large-scale

    E-Print Network [OSTI]

    A. Gershunov Ć R. Roca Coupling of latent heat flux and the greenhouse effect by large Abstract Coupled variability of the greenhouse effect (GH) and latent heat flux (LHF) over the tropical of convection) form regions of strong greenhouse effect in tropical convergence zones while subtropical high

  9. Rapid Communication Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are

    E-Print Network [OSTI]

    Knipe, David M.

    Rapid Communication Herpes simplex virus 1 microRNAs expressed abundantly during latent infection Available online 23 July 2011 Keywords: Herpes simplex virus MicroRNAs Latency Gene regulation Several herpes simplex virus 1 microRNAs are encoded within or near the latency associated transcript (LAT) locus

  10. Condensation Risk in a Room with High Latent Load and Chilled Ceiling

    E-Print Network [OSTI]

    Chen, Qingyan "Yan"

    proposed a new ventilation system with radiant cooling panel and air supplied from a liquid desiccant dehumidification system, which provided very dry supply air and chilled water for radiant cooling. This study usedCondensation Risk in a Room with High Latent Load and Chilled Ceiling Panel and with Air Supplied

  11. Latent Gaussian Models for Topic Modeling Changwei Hu Eunsu Ryu David Carlson Yingjian Wang Lawrence Carin

    E-Print Network [OSTI]

    Kaski, Samuel

    of legislation (Gerrish & Blei, 2011; Zhang & Carin, 2012), where the text of the legislation is in terms of p1. Typically it is assumed that Xij 0 for all (i, j). In latent Dirichlet allocation (LDA) (Blei et al., 2003 developed topic models, like the nested Chinese restaurant process (nCRP)(Blei et al., 2010; Wang & Blei

  12. Paternal age related schizophrenia (PARS): latent subgroups detected by k-means clustering analysis

    E-Print Network [OSTI]

    Ahn, Hongshik

    1 Paternal age related schizophrenia (PARS): latent subgroups detected by k-means clustering of schizophrenia with distinct etiology, pathophysiology and symptoms. This study uses a k-means clustering-R) and olfaction (University of Pennsylvania Smell Identification Test; UPSIT). We conducted a series of k-means

  13. Efficient Energy Management and Data Recovery in Sensor Networks using Latent Variables Based Tensor

    E-Print Network [OSTI]

    Simunic, Tajana

    Efficient Energy Management and Data Recovery in Sensor Networks using Latent Variables Based factor in a successful sensor network deployment is finding a good balance between maximizing the number of measurements taken (to maintain a good sampling rate) and minimizing the overall energy consumption (to extend

  14. Segmentation and Enhancement of Latent Fingerprints: A Coarse to Fine Ridge

    E-Print Network [OSTI]

    ., "Image Quality Assessment: From Error Visibility to Structural Similarity", IEEE Transaction on ImageSegmentation and Enhancement of Latent Fingerprints: A Coarse to Fine Ridge Structure Dictionary ridge Pores · Include all dimensional attributes of the ridge such as pores, edge contour, incipient

  15. Experimental Research on Solar Assisted Heat Pump Heating System with Latent Heat Storage 

    E-Print Network [OSTI]

    Han, Z.; Zheng, M.; Liu, W.; Wang, F.

    2006-01-01T23:59:59.000Z

    Assisted Heat Pump Heating System with Latent Heat Storage. In this system, solar energy is the major heat source for a heat pump, and the supplementary heat source is soil. The disagreement in time between the space heat load and heat collected by solar...

  16. Determination of solid fractiontemperature relation and latent heat using full scale

    E-Print Network [OSTI]

    Beckermann, Christoph

    on five such corrosion resistant alloys: superaustenitic stainless steel CN3MN, duplex stainless steels CD available. The alloys selected consist of three stainless steels (super- austenitic CN3MN and duplexes CD3MN, Latent heat, Stainless steels, Nickel based alloys Introduction Casting simulation is routinely used

  17. MARINE STRATUS CLOUD LIFECYCLE MODULATED BY LATENT HEAT FLUX IN A COASTAL OCEAN UPWELLING REGION

    E-Print Network [OSTI]

    MARINE STRATUS CLOUD LIFECYCLE MODULATED BY LATENT HEAT FLUX IN A COASTAL OCEAN UPWELLING REGION, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark

  18. Tuberculosis and Latent TB Treatment Approved by the UHS Patient Education Committee

    E-Print Network [OSTI]

    Yener, Aylin

    health care Who abuse drugs and/or alcohol Who work or are residents of long-term care facilities return to the health care worker who will check to see if there is a reaction to the test. A positive tell the health care worker prior to having the test repeated. #12;Tuberculosis and Latent TB Treatment

  19. Latent Friend Mining from Blog Data , Jian-Tao Sun2

    E-Print Network [OSTI]

    Yang, Qiang

    , it is not easy to obtain and maintain the profiles manually. Therefore, the automatic approaches in mining usersLatent Friend Mining from Blog Data Dou Shen1 , Jian-Tao Sun2 , Qiang Yang1 , Zheng Chen2 1 in recent years with benefits for different types of users. For individuals, the Web community helps

  20. STOMACH CANCER 9. STOMACH CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    of association and strength of evidence Increases risk Decreases risk Convincing or probable Helicobacter pylori/obesity 9 1 Helicobacter and Cancer Collaborative Group, 2001; 2 International Agency for Research on Cancer

  1. From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory

    SciTech Connect (OSTI)

    Martineau, Rebecca M [Los Alamos National Laboratory

    2012-07-26T23:59:59.000Z

    In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

  2. Projecting Fatalities in Crashes Involving Older Drivers, 2000–2025, CRADA No. ORNL98-0500 Final Report

    SciTech Connect (OSTI)

    Hu, Patricia S. [ORNL] [ORNL; Jones, Donald W. [ORNL] [ORNL; Reuscher, Timothy [Oak Ridge Institute for Science and Education] [Oak Ridge Institute for Science and Education; Schmoyer, Richard S. [ORNL] [ORNL; Truett, Lorena F. [ORNL] [ORNL

    2000-04-01T23:59:59.000Z

    At the turn of the century – the 20th century that is – the median age in the United States was under 30 years; America was 60% rural in nature; and there were only 36 highway fatalities all year. As we leave the 20th century behind, the route into the 21st century is very different. “Intelligent” cars speed down multi-lane “smart” highways in a nation that is 75% urban. According to the Federal Highway Administration’s Highway Statistics, there are 28,000 times more vehicles on the road in 2000 than there were in 1900, and these vehicles travel about 2.6 trillion miles each year. Annual fatalities resulting from highway crashes have also increased – by over 1100%. We see other changes as well. The face of America is changing. It is growing older. In 2025, persons 65 and over will make up 18.5% of the total population. The number of persons aged 85 and over is increasing more rapidly than any other age group. More importantly, the elderly are taking more trips, driving further, and continuing to drive much later in life. These conditions lead to concerns about traffic safety. Although the elderly are healthier and drive safer cars than they did just two decades ago, their frailty makes them more susceptible to injury than younger persons involved in traffic crashes of the same severity. In addition, visual, physical, and cognitive skills, all of which contribute to driving abilities, decrease with advancing age. The familiar “U”-shaped curve depicting the rate of fatalities per vehicle miles traveled, shows that the elderly experience a higher highway fatality rate than any other age group except teenagers. While the overall number of highway fatalities has decreased regularly since 1972, the number of fatalities of elderly travelers has continued to increase steadily. This increase is cause for concern for both the elderly driver and for other persons on the roads who migh tbe placed in danger through crashes involving elderly drivers.

  3. Assessment and Prediction of the Thermal Performance of a Centralized Latent Heat Thermal Energy Storage Utilizing Artificial Neural Network

    E-Print Network [OSTI]

    El-Sawi, A.; Haghighat, F.; Akbari, H.

    2013-01-01T23:59:59.000Z

    A simulation tool is developed to analyze the thermal performance of a centralized latent heat thermal energy storage system (LHTES) using computational fluid dynamics (CFD). The LHTES system is integrated with a mechanical ventilation system...

  4. Exploring potential R&D collaboration partners through patent analysis based on bibliographic coupling and latent semantic analysis

    E-Print Network [OSTI]

    Park, I.; Jeong, Y.; Yoon, B.; Mortara, L.

    2014-10-22T23:59:59.000Z

    on the citation relationship using patent bibliographic information. Second, latent semantic analysis is utilized based on semantic similarity using patent textual information. The fuel cell membrane electrode assembly (MEA) technology field is selected...

  5. Experimental investigation of the latent heat of vaporization in aqueous nanofluids

    SciTech Connect (OSTI)

    Lee, Soochan; Phelan, Patrick E., E-mail: phelan@asu.edu; Dai, Lenore; Prasher, Ravi; Gunawan, Andrey [School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, Arizona 85287-6106 (United States); Taylor, Robert A. [School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney 2052 (Australia)

    2014-04-14T23:59:59.000Z

    This paper reports an experimental investigation of the latent heat of vaporization (h{sub fg}) in nanofluids. Two different types of nanoparticles, graphite and silver, suspended in deionized water were exposed to a continuous laser beam (130 mW, 532?nm) to generate boiling. The latent heat of vaporization in the nanofluids was determined by the measured vapor mass generation and the heat input. To ensure that the measured h{sub fg} values are independent of heating method, the experiments were repeated with an electrically heated hot wire as a primary heat input. These experiments show considerable variation in the h{sub fg} of nanofluids. That is, graphite nanofluid exhibits an increased h{sub fg} and silver nanofluid shows a decrease in h{sub fg} compared to the value for pure water. As such, these results indicate that relatively low mass fractions of nanoparticles can apparently create large changes in h{sub fg}.

  6. CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM 2010 ANNUAL REPORT WITH STATISTICAL DATA FROM 2009 UNIVERSITY OF ILLINOIS MEDICAL CENTER #12;2 CANCER PROGRAM ANNUAL REPORT 2 #12;3 CANCER PROGRAM ANNUAL REPORT 3 UIMC CANCER PROGRAM CHANGING MULTIDISCIPLINARY CARE. FOR GOOD. #12;4 CANCER PROGRAM ANNUAL REPORT

  7. SU(3) Latent Heat and Surface Tension from Tree Level and Tadpole Improved Actions

    E-Print Network [OSTI]

    B. Beinlich; F. Karsch; A. Peikert

    1996-08-27T23:59:59.000Z

    We analyze the latent heat and surface tension at the SU(3) deconfinement phase transition with tree level and tadpole improved Symanzik actions on lattices with temporal extent $N_\\tau = 3$ and 4 and spatial extent $N_\\sigma/ N_\\tau = 4$, 6 and 8. In comparison to the standard Wilson action we do find a drastic reduction of cut-off effects already with tree level improved actions. On lattices with temporal extent $N_\\tau=4$ results for the surface tension and latent heat obtained with a tree level improved action agree well with those obtained with a tadpole improved action. A comparison with $N_\\tau=3$ calculations, however, shows that results obtained with tadpole action remain unaffected by cut-off effects even on this coarse lattice, while the tree level action becomes sensitive to the cut-off. For the surface tension and latent heat we find $\\sigma_I/ T_c^3 = 0.0155~(16)$ and $\\Delta\\epsilon/T_c^4 = 1.40~(9)$, respectively.

  8. SU(3) Latent Heat and Surface Tension from Tree Level and Tadpole Improved Actions

    E-Print Network [OSTI]

    Beinlich, B; Peikert, A

    1996-01-01T23:59:59.000Z

    We analyze the latent heat and surface tension at the SU(3) deconfinement phase transition with tree level and tadpole improved Symanzik actions on lattices with temporal extent $N_\\tau = 3$ and 4 and spatial extent $N_\\sigma/ N_\\tau = 4$, 6 and 8. In comparison to the standard Wilson action we do find a drastic reduction of cut-off effects already with tree level improved actions. On lattices with temporal extent $N_\\tau=4$ results for the surface tension and latent heat obtained with a tree level improved action agree well with those obtained with a tadpole improved action. A comparison with $N_\\tau=3$ calculations, however, shows that results obtained with tadpole action remain unaffected by cut-off effects even on this coarse lattice, while the tree level action becomes sensitive to the cut-off. For the surface tension and latent heat we find $\\sigma_I/ T_c^3 = 0.0155~(16)$ and $\\Delta\\epsilon/T_c^4 = 1.40~(9)$, respectively.

  9. Cancer Imaging Clinical Cancer Research

    E-Print Network [OSTI]

    Near Ir; Heptamethine Cyanine Dye–mediated; Xiaojian Yang; Chunmeng Shi; Rong Tong; Weiping Qian; Haiyen E. Zhau; Ruoxiang Wang; Guodong Zhu; Jianjun Cheng; Vincent W. Yang; Tianmin Cheng; Maged Henary; Lucjan Strekowski; W. K. Chung

    Purpose: Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging of tumors. In this study, we show the preferential uptake and retention of two hepatamethine cyanine dyes, IR-783 and MHI-148, in tumor cells and tissues. Experimental Design: IR-783 and MHI-148 were investigated for their ability to accumulate in human cancer cells, tumor xenografts, and spontaneous mouse tumors in transgenic animals. Time- and concentration-dependent dye uptake and retention in normal and cancer cells and tissues were compared, and subcellular localization of the dyes and mechanisms of the dye uptake and retention in tumor cells were evaluated using organelle-specific tracking dyes and bromosulfophthalein, a competitive inhibitor of organic anion transporting peptides. These dyes were used to detect human cancer metastases in a mouse model and differentiate cancer cells from normal cells in blood. Results: These near-IR hepatamethine cyanine dyes were retained in cancer cells but not normal cells, in tumor xenografts, and in spontaneous tumors in transgenic mice. They can be used to detect cancer metastasis and cancer cells in blood with a high degree of sensitivity. The dyes were found to concentrate in the mitochondria and lysosomes of cancer cells, probably through organic anion transporting peptides,

  10. Method for charging and discharging a latent-heat storage medium and heat storage

    SciTech Connect (OSTI)

    Kreikenbohm, R.; Reusch, H.

    1982-12-28T23:59:59.000Z

    A heat storage unit is disclosed having a vertically cylindrical container accommodating a latent-heat storage medium and a conduit introducing a heat carrier liquid not miscible with the medium at the bottom of the container. The conduit has an exit nozzle which is located outside the axial center of the cylinder and nearly perpendicular to the radius of the cylinder so that the heat carrier liquid enters the cylinder at the bottom in a direction to cause the heat storage melt to be set into a rotary motion.

  11. Method for charging and discharging a latent-heat storage medium and heat storage

    SciTech Connect (OSTI)

    Kreikenbohm, R.; Reusch, H.

    1981-10-13T23:59:59.000Z

    A heat storage unit is disclosed having a vertically cylindrical container accommodating a latent-heat storage medium and a conduit introducing a heat carrier liquid not miscible with the medium at the bottom of the container. The conduit has an exit nozzle which is located outside the axial center of the cylinder and nearly perpendicular to the radius of the cylinder so that the heat carrier liquid enters the cylinder at the bottom in a direction to cause the heat storage melt to be set into a rotary motion.

  12. Complications associated with brachytherapy alone or with laser in lung cancer

    SciTech Connect (OSTI)

    Khanavkar, B.; Stern, P.; Alberti, W.; Nakhosteen, J.A. (Augusta Teaching Hospital, Bochum (West Germany))

    1991-05-01T23:59:59.000Z

    Relatively little has been reported about destruction through brachytherapy of mucosa-perforating and extraluminary tumors with probable large vessel involvement causing major hemorrhagic or fistular complications. We report 12 patients subjected to laser and brachytherapy for centrally occluding lung cancer, whom we have periodically followed up from June 1986 until they died. Although all laser procedures were free from complications, necrotic cavitation in five cases, two of which were accompanied by large bronchoesophageal fistulas, and massive fatal hemoptysis occurred in six. Minor complications included radiation mucositis (two), noncritical mucosal scarring (two), and cough (four). Characteristics that will identify patients at risk of developing fatal hemoptysis and fistulas should be better defined by imaging and endoscopic techniques. In such cases, modifying the protocol or using alternative procedures should be considered. Minor complications, such as cough, can be avoided by using topical steroid therapy (eg, beclomethasone dipropionate).

  13. Full-scale study of a building equipped with phase change material wallboards and a multi-layer rack latent heat thermal energy store system

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    -layer rack latent heat thermal energy store system Julien Borderon1 , Joseph Virgone2 , Richard Cantin1 installed as wallboard and as latent heat thermal energy storage system coupled with the ventilation system for the ventilation air is efficient. INTRODUCTION Nowadays, thermal energy storage systems are one way for reducing

  14. Bird Risk Behaviors and Fatalities at the Altamont Pass Wind Resource Area: Period of Performance, March 1998--December 2000

    SciTech Connect (OSTI)

    Thelander, C. G.; Smallwood, K. S.; Rugge, L.

    2003-12-01T23:59:59.000Z

    It has been documented that wind turbine operations at the Altamont Pass Wind Resource Area kill large numbers of birds of multiple species, including raptors. We initiated a study that integrates research on bird behaviors, raptor prey availability, turbine design, inter-turbine distribution, landscape attributes, and range management practices to explain the variation in avian mortality at two levels of analysis: the turbine and the string of turbines. We found that inter-specific differences in intensities of use of airspace within close proximity did not explain the variation in mortality among species. Unique suites of attributes relate to mortality of each species, so species-specific analyses are required to understand the factors that underlie turbine-caused fatalities. We found that golden eagles are killed by turbines located in the canyons and that rock piles produced during preparation of the wind tower laydown areas related positively to eagle mortality, perhaps due to the use of these rock piles as cover by desert cottontails. Other similar relationships between fatalities and environmental factors are identified and discussed. The tasks remaining to complete the project are summarized.

  15. The following are typical equations and conversions for calculating flux densities of sensible, latent and carbon dioxide from eddy covariances presented by Kevin Tu, St. Louis (10/97). The

    E-Print Network [OSTI]

    Tu, Kevin

    , latent and carbon dioxide from eddy covariances presented by Kevin Tu, St. Louis (10/97). The properties

  16. Josephine Ford Cancer Center Cancer Research Programs

    E-Print Network [OSTI]

    Berdichevsky, Victor

    Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

  17. Task Modeling in Imitation Learning using Latent Variable Models Carl Henrik Ek, Dan Song, Kai Huebner and Danica Kragic

    E-Print Network [OSTI]

    Ek, Carl Henrik

    in the sensorimotor systems, [4] proposed a coherent control, trajectory optimization, and action planningTask Modeling in Imitation Learning using Latent Variable Models Carl Henrik Ek, Dan Song, Kai about different manipulation tasks from scene observations. In this paper we present a probabilistic

  18. A Framework for Incorporating General Domain Knowledge into Latent Dirichlet Allocation using First-Order Logic

    SciTech Connect (OSTI)

    Andrzejewski, D; Zhu, X; Craven, M; Recht, B

    2011-01-18T23:59:59.000Z

    Topic models have been used successfully for a variety of problems, often in the form of application-specific extensions of the basic Latent Dirichlet Allocation (LDA) model. Because deriving these new models in order to encode domain knowledge can be difficult and time-consuming, we propose the Fold-all model, which allows the user to specify general domain knowledge in First-Order Logic (FOL). However, combining topic modeling with FOL can result in inference problems beyond the capabilities of existing techniques. We have therefore developed a scalable inference technique using stochastic gradient descent which may also be useful to the Markov Logic Network (MLN) research community. Experiments demonstrate the expressive power of Fold-all, as well as the scalability of our proposed inference method.

  19. 1 888 939 3333 | cancer.ca Cancer Statistics

    E-Print Network [OSTI]

    Habib, Ayman

    1 888 939 3333 | cancer.ca Canadian Cancer Statistics 2013 Special topic: Liver cancer Produced by Canadian Cancer Society, Statistics Canada, Public Health Agency of Canada, Provincial/Territorial Cancer Registries cancer.ca/statistics #12;2Canadian Cancer Society n Canadian Cancer Statistics 2013 Citation

  20. Fatal self-poisoning with lithium carbonate M.R. Achong, b sc, mb; P.G. Fernandez, mrcp, frcp[c]; P.J. McLeod, md, frcp[c

    E-Print Network [OSTI]

    Laughlin, Robert B.

    Fatal self-poisoning with lithium carbonate M.R. Achong, b sc, mb; P.G. Fernandez, mrcp, frcp[c]; P.J. McLeod, md, frcp[c] Summary: In a fatal case of self- poisoning with lithium carbonate

  1. Webinar on Improving Methods for Estimating Fatality of Birds and Bats at Wind Energy Facilities 10Noon Pacific Wednesday, September 26, 2012

    E-Print Network [OSTI]

    Webinar on Improving Methods for Estimating Fatality of Birds and Bats at Wind Energy Facilities 10 results from a California Wind Energy Association (CalWEA)sponsored, California Energy Commissionfunded associated with wind energy facilities, including an improved equation developed to adjust mortality

  2. correspondence between case reports and fatality data. These data also establish that mortality rates are not affected by epidemic phase24

    E-Print Network [OSTI]

    Tian, Weidong

    mortality due to measles and whooping cough during these periods. Estimates of case fatality rates for whooping cough are in the 3­15% range24 . Data analysis These time series contain a substantial annual, analyses of the relationship between measles and whooping cough outbreaks were carried out on de

  3. Degraded Modes and the `Culture of Coping' in Military Operations: An Analysis of a Fatal Incident On-Board HMS Tireless on 20/21 March 2007

    E-Print Network [OSTI]

    Johnson, Chris

    was following Standard operating Procedures (SOPs) using Self Contained Oxygen Generators (SCOGs) to maintain and operators must work together to ensure that maintenance intervals are scheduled so that critical componentsDegraded Modes and the `Culture of Coping' in Military Operations: An Analysis of a Fatal Incident

  4. Geographic and Demographic Patterns of Alcohol-Related Fatal Traffic Crashes: A Spatial-Temporal Analysis in Texas, 1996-2005

    E-Print Network [OSTI]

    Rolland, Gabriel A.

    2010-01-16T23:59:59.000Z

    major cause of fatal crashes in Texas. Specifically, this paper targets those drivers that were killed while driving under the influence (0.01 BAC). With an increase in manageable data and the ease of availability of aggregated crash records, accident...

  5. Type A Accident Investigation Board Report on the February 13, 1997, Welding/Cutting Fatality at the K-33 Building, K-25 Site, Oak Ridge, Tennessee

    Broader source: Energy.gov [DOE]

    On February 13, 1997, at approximately 11:10 a.m., a welder (referred to as “the Welder”) using a cutting torch at the K-33 Building, Oak Ridge K-25 Site, Oak Ridge Reservation, was fatally burned after being totally engulfed in flames when his anti-contamination coveralls and blue general-purpose coveralls burned.

  6. Type A Accident Investigation Report on the June 25, 1997, Contractor Inspector Fatality on the Satsop-Aberdeen #2 & #3 230 kV Line

    Broader source: Energy.gov [DOE]

    On June 27, 1997, I established a Type-A Accident Investigation Board to investigate the June 25, 1997 fatal contractor accident which occurred on BPA?s Satsop-Aberdeen #2 and #3 230-kV transmission lines right-of-way.

  7. Type A Accident Investigation Board Report of the April 25, 1997, Contractor Fatality on the Olympia-White River #1 230 kV Line

    Broader source: Energy.gov [DOE]

    On April 25, 1997, at approximately 1510 hours, a lineman for Great Southwestern Construction Inc. was fatally electrocuted when he came in direct contact with a deenergized 230-kilovolt (kV) transmission power line conductor which contained an induced voltage.

  8. Heat Transfer and Latent Heat Storage in Inorganic Molten Salts for Concentrating Solar Power Plants

    SciTech Connect (OSTI)

    Mathur, Anoop [Terrafore Inc.] [Terrafore Inc.

    2013-08-14T23:59:59.000Z

    A key technological issue facing the success of future Concentrating Solar Thermal Power (CSP) plants is creating an economical Thermal Energy Storage (TES) system. Current TES systems use either sensible heat in fluids such as oil, or molten salts, or use thermal stratification in a dual-media consisting of a solid and a heat-transfer fluid. However, utilizing the heat of fusion in inorganic molten salt mixtures in addition to sensible heat , as in a Phase change material (PCM)-based TES, can significantly increase the energy density of storage requiring less salt and smaller containers. A major issue that is preventing the commercial use of PCM-based TES is that it is difficult to discharge the latent heat stored in the PCM melt. This is because when heat is extracted, the melt solidifies onto the heat exchanger surface decreasing the heat transfer. Even a few millimeters of thickness of solid material on heat transfer surface results in a large drop in heat transfer due to the low thermal conductivity of solid PCM. Thus, to maintain the desired heat rate, the heat exchange area must be large which increases cost. This project demonstrated that the heat transfer coefficient can be increase ten-fold by using forced convection by pumping a hyper-eutectic salt mixture over specially coated heat exchanger tubes. However,only 15% of the latent heat is used against a goal of 40% resulting in a projected cost savings of only 17% against a goal of 30%. Based on the failure mode effect analysis and experience with pumping salt at near freezing point significant care must be used during operation which can increase the operating costs. Therefore, we conclude the savings are marginal to justify using this concept for PCM-TES over a two-tank TES. The report documents the specialty coatings, the composition and morphology of hypereutectic salt mixtures and the results from the experiment conducted with the active heat exchanger along with the lessons learnt during experimentation.

  9. CANCER BIOLOGY Infectioustumourcells

    E-Print Network [OSTI]

    Nowak, Martin A.

    CANCER BIOLOGY Infectioustumourcells David Dingli and Martin A. Nowak Cancer cells are generally infectious agents and be transmitted between individuals. The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer- promoting

  10. The National Cancer Institute,

    E-Print Network [OSTI]

    The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

  11. Modeling threat assessments of water supply systems using markov latent effects methodology.

    SciTech Connect (OSTI)

    Silva, Consuelo Juanita

    2006-12-01T23:59:59.000Z

    Recent amendments to the Safe Drinking Water Act emphasize efforts toward safeguarding our nation's water supplies against attack and contamination. Specifically, the Public Health Security and Bioterrorism Preparedness and Response Act of 2002 established requirements for each community water system serving more than 3300 people to conduct an assessment of the vulnerability of its system to a terrorist attack or other intentional acts. Integral to evaluating system vulnerability is the threat assessment, which is the process by which the credibility of a threat is quantified. Unfortunately, full probabilistic assessment is generally not feasible, as there is insufficient experience and/or data to quantify the associated probabilities. For this reason, an alternative approach is proposed based on Markov Latent Effects (MLE) modeling, which provides a framework for quantifying imprecise subjective metrics through possibilistic or fuzzy mathematics. Here, an MLE model for water systems is developed and demonstrated to determine threat assessments for different scenarios identified by the assailant, asset, and means. Scenario assailants include terrorists, insiders, and vandals. Assets include a water treatment plant, water storage tank, node, pipeline, well, and a pump station. Means used in attacks include contamination (onsite chemicals, biological and chemical), explosives and vandalism. Results demonstrated highest threats are vandalism events and least likely events are those performed by a terrorist.

  12. CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER

    E-Print Network [OSTI]

    Sherman, S. Murray

    CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

  13. Paul Workman Cancer Research UK Cancer Therapeutics Unit

    E-Print Network [OSTI]

    Paul Workman Cancer Research UK Cancer Therapeutics Unit Institute of Cancer Research/Royal Marsden Hospital Sutton, Surrey SM2 5NG UK ian.collins@icr.ac.uk Drugging the cancer genome: The challenges therapeutic agents Personalised diagnosis and treatment Exploiting cancer biology and the cancer genome

  14. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Colorectal cancer Colorectal cancer Colorectal

    E-Print Network [OSTI]

    Paxton, Anthony T.

    explain the higher US survival rate. Aggressive treatment may also be a factor. 5. Colorectal cancer Risks--22000000 28 Colorectal cancer Colorectal cancer Colorectal cancer Colorectal cancer Colorectal cancer Col orectal cancer Colorectal cancer Colorectal ca ncer Colorectal cancer Colorectal cancer Color ectal cancer

  15. Cancer Research Beckman Institute

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Cancer Research Beckman Institute FOR ADVANCED SCIENCE AND TECHNOLOGY #12;T The medical and scientific worlds have known for many years that in order to truly understand and treat cancer, the fight has and cancerous tumors have to first be visualized at the smallest scales possible, and then treated in the most

  16. Analysis of Assembly Bill 1000: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01T23:59:59.000Z

    of recurrent cancers, and treatment of cancers that cannotNeill VJ, Twelves CJ. Oral cancer treatment: Developments inchanging paradigm in cancer treatment: Oral chemotherapy.

  17. Analysis of Senate Bill 961: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2010-01-01T23:59:59.000Z

    of recurrent cancers, and treatment of cancers that cannotNeill VJ, Twelves CJ. Oral cancer treatment: Developments inchanging paradigm in cancer treatment: Oral chemotherapy.

  18. Lymphatic and Angiogenic Candidate Genes Predict the Development of Secondary Lymphedema following Breast Cancer Surgery

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    following breast cancer treatment. Cancer Epidemiollymphedema after breast cancer treatment. Cancer Epidemiolfollowing breast cancer treatment. Clin Cancer Res 18: 232–

  19. Sensitivity and uncertainty studies of the CRAC2 code for selected non-meteorological models and parameters

    SciTech Connect (OSTI)

    Kocher, D.C.; Killough, G.G.; Dunning, D.E. Jr.

    1985-01-01T23:59:59.000Z

    We have studied the sensitivity of health impacts and economic costs from hypothetical nuclear reactor accidents, as predicted by the CRAC2 computer code, to undertainties in selected non-meteorological models and parameters. The sources of uncertainty include (1) dose conversion factors for inhalation as affected by uncertainties in the particle size of the carrier aerosol and clearance of radionuclides from the respiratory tract, (2) the weathering half-time for external ground-surface exposure, and (3) transfer coefficients for terrestrial foodchain pathways. Uncertainties in inhalation dose conversion factors affected predicted early injuries by as much as 1 to 2 orders of magnitude in runs with fixed weather sequences, whereas the effects on early fatalities were less than a factor of 2 and on latent cancer fatalities less than 10%. Uncertainties in the weathering half-time for ground-surface exposure affected latent fatalities by a factor of 2 to 3 but economic costs by less than a factor of 2. Uncertainties in the transfer coefficients for terrestrial foodchain pathways affected latent fatalities by less than 15% and had no effect on economic costs. 10 references.

  20. Eur J Cancer. Author manuscript Social inequalities in cancer incidence and cancer survival: Lessons from

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Eur J Cancer. Author manuscript Page /1 5 Social inequalities in cancer incidence and cancer ( ). With regards to cancer risk, a first comprehensive review of socioeconomic inequalities was1 published by IARC in 1997 ( ). This review covered inequalities in cancer mortality, incidence and survival and discussed

  1. Cancer Due to Prolonged Inflammation

    E-Print Network [OSTI]

    Lingampalli, Nithya

    2013-01-01T23:59:59.000Z

    Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

  2. Bismuth 213 Cancer Treatment

    ScienceCinema (OSTI)

    None

    2013-05-28T23:59:59.000Z

    See how INL scientists are increasing supplies of radioactive medical isotopes to treat cancer. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  3. Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA15 pathway

    E-Print Network [OSTI]

    Poole, Emma; Lau, Jonathan; Sinclair, John

    2015-05-08T23:59:59.000Z

    ., Breidenstein, A. & Compton, T. (2012). Human cytomegalovirus activation of ERK 214 and myeloid cell leukemia-1 protein correlates with survival of latently infected cells. Proc 215 Natl Acad Sci U S A 109, 588-593. 216 Reeves, M. B., MacAry, P. A., Lehner, P...

  4. Disaggregating Cooling Energy Use of Commercial Buildings Into Sensible and Latent Fractions From Whole-Building Monitored Data: Methodology and Advantages

    E-Print Network [OSTI]

    Katipamula, S.; Reddy, T. A.; Claridge, D. E.

    In hot and humid climates, where summers are both warm and humid, the latent cooling can be a significant portion of the total cooling load (as much as 40%). Typically the monitored data only includes whole-building heating and cooling energy use...

  5. Simulated and observed fluxes of sensible and latent heat and CO2 at the WLEF-TV tower using SiB2.5

    E-Print Network [OSTI]

    Collett Jr., Jeffrey L.

    Simulated and observed fluxes of sensible and latent heat and CO2 at the WLEF-TV tower using SiB2, Boulder, CO, USA Abstract Three years of meteorological data collected at the WLEF-TV tower were used the WLEF tower, which were not present in the SiB simulation. The model overestimated the magnitude

  6. Fatal Flaw Analysis of Utility-Scale Wind Turbine Generators at the West Haymarket Joint Public Agency. A Study Prepared in Partnership with the Environmental Protection Agency for the RE-Powering America's Land Initiative: Siting Renewable Energy on Potentially Contaminated Land and Mine Sites

    SciTech Connect (OSTI)

    Roberts, J. O.; Mosey, G.

    2013-08-01T23:59:59.000Z

    Fatal flaw analysis of utility-scale wind turbines at the West Haymarket Joint Public Agency brownfields site in Lincoln, Nebraska, funded by EPA.

  7. Skin metastases from lung cancer

    E-Print Network [OSTI]

    Mollet, Todd W; Garcia, Carlos A; Koester, Glenn

    2009-01-01T23:59:59.000Z

    cutaneous metastases from the lung frequently indicate aof skin metastases from lung cancer. Intern Med. 1996; 35:9. Coslett LM, Katlic MR. Lung cancer with skin metastasis.

  8. Inflammation & Inflammation & cancer

    E-Print Network [OSTI]

    Beimel, Amos

    Tam & tnf dc cytokines metastasis metabolism #12;22 chemokine gradient in cancer (Balkwill et al. 2004 1861) Wound healing dc Tam & tnf cytokines metastasis therapeutics metabolism inflammation The end #12 & tnf cytokines metastasis metabolism #12;4 Motivation Cancer as an overhealing wound Lets Go! Wound

  9. Lung cancer...115 Chapter 11

    E-Print Network [OSTI]

    Paxton, Anthony T.

    NICR/NCRI Lung cancer...115 Chapter 11: Lung cancer (including trachea, bronchus and lung; C33-C34 of lung cancer diagnosed each year in Ireland during 2000-2004. o Male incidence rates decreased by 1 by 2.7%. o Higher levels of treatment occurred among those with small cell lung cancer (compared to non

  10. QUESTIONS & ANSWERS ABOUT LUNG CANCER

    E-Print Network [OSTI]

    QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

  11. Cancer Therapies: A Bane and a Boon

    E-Print Network [OSTI]

    Neogi, Sushrita

    2012-01-01T23:59:59.000Z

    Alternative Medicine in Cancer Treatment. (2012). Retrievedcancertopics/pdq/cam/cam-cancer-treatment/patient/page2 8.and alternative (CAM) cancer treatments in use, including

  12. Evidence That New Hypnotics Cause Cancer

    E-Print Network [OSTI]

    Kripke, Daniel F.

    2008-01-01T23:59:59.000Z

    medication use and risk of epithelial ovarian cancer.Cancer Epidemiol. Biomarkers Prev. , Hays, J. C. , Blazer,the likelihood of cancer causation is sufficiently strong

  13. Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer

    E-Print Network [OSTI]

    Weber, David J.

    Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program ­ Genetic Epidemiology of Cancer Associate Professor Tenuretrack Health is expanding research in Cancer Genetic Epidemiology to enrich an already robust campuswide

  14. Colorectal cancer and diet in Scotland 

    E-Print Network [OSTI]

    Theodoratou, Evropi

    2008-01-01T23:59:59.000Z

    Introduction Colorectal cancer is a cancer that forms in the tissues of the colon and/ or rectum and more than 95% of colorectal cancers are adenocarcinomas. It is the third most common cancer in incidence and mortality ...

  15. Identifying Risk Groups Associated with Colorectal Cancer

    E-Print Network [OSTI]

    Jin, Huidong "Warren"

    , abbreviated as CRC) is the second leading cause of cancer-related deaths in the United States for both men to lung cancer in cause of cancer deaths. Despite the fact that it is highly preventable, approximately, colorectal cancer is the third most common cause of death from cancer in women (after breast and lung cancer

  16. Cell Senescence: Aging and Cancer

    ScienceCinema (OSTI)

    Campisi, Judith

    2013-05-29T23:59:59.000Z

    Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

  17. Hindawi Publishing Corporation Prostate Cancer

    E-Print Network [OSTI]

    Ahn, Hongshik

    Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 176164, 7 pages doi:10.1155/2011/176164 Clinical Study Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone

  18. Early Lung Cancer Detection Program

    Broader source: Energy.gov [DOE]

    Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

  19. Pomegranate Juice and Pomegranate Derived Natural Products as Alternative Treatment for Cancer Progression and Metastasis

    E-Print Network [OSTI]

    Wang, Lei

    2013-01-01T23:59:59.000Z

    prostate cancer. Cancer Treatment Reviews 36, Sternlicht,prostate cancer. Cancer Treatment Reviews 36, Steiner, H. ,prostate cancer. Cancer Treatment Reviews 36, Sureban,

  20. Environmental Impacts of Transportation to the Potential Repository at Yucca Mountain

    SciTech Connect (OSTI)

    R.L. Sweeney; R. Best; P. Bolton; P. Adams

    2002-01-03T23:59:59.000Z

    The Environmental Impact Statement for a Geologic Repository for the Disposal of Spent Nuclear Fuel and High-Level Radioactive Waste at Yucca Mountain, Nye County, Nevada analyzes a Proposed Action to construct, operate, monitor, and eventually close a geologic repository for the disposal of spent nuclear fuel and high-level radioactive waste. As part of the Proposed Action, the EIS analyzes the potential impacts of transporting commercial and DOE spent nuclear fuel and high-level radioactive waste to Yucca Mountain from 77 sites across the United States. The analysis includes information on the comparative impacts of transporting these materials by truck and rail and discusses the impacts of building a rail line or using heavy-haul trucks to move rail casks from a mainline railroad in Nevada to the site. This paper provides an overview of the analyses and the potential impacts of these transportation activities. The potential transportation impacts were looked at from two perspectives: transportation of spent nuclear fuel and high-level radioactive waste by legal-weight truck or by rail on a national scale and impacts specific to Nevada from the transportation of these materials from the State borders to the Yucca Mountain site. In order to address the range of impacts that could result from the most likely modes, legal-weight truck and rail, the EIS employed two analytical scenarios--mostly legal-weight truck and mostly rail. Estimated national transportation impacts were based on 24 years of transportation activities. Approximately 8 fatalities could occur from all causes in the nationwide general population from incident-free transportation activities of the mostly legal-weight truck scenario and about 4 from the mostly rail scenario. The analysis examined the radiological consequences under the maximum foreseeable accident scenario and also overall accident risk. The overall accident risk over the 24 year period would be about 0.0002 latent cancer fatality for the mostly legal-weight truck scenario and about 0.0005 latent cancer fatality for the mostly rail scenario. The maximum reasonably foreseeable accident scenario resulted in 0.55 latent cancer fatality for the legal-weight truck case and 5 latent cancer fatalities in the case of mostly rail. The EIS also analyzed the impacts associated with the transportation of spent nuclear fuel and high-level radioactive waste in the State of Nevada. This included: constructing a branch rail line and using it to ship waste to the repository; upgrading highways in Nevada for use by heavy-haul trucks; constructing and operating an intermodal transfer station; and transporting personnel and materials to support construction and operation of the repository.

  1. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    Hunter DJ, Willett WC (1996): Nutrition and breast cancer.Cancer Causes Control 7:56- 37. Weiderpass E, Braaten T,of premenopausal breast cancer. Cancer Epidemiol.Biomarkers

  2. Prognosis of Breast Cancer using Genetic Programming

    E-Print Network [OSTI]

    Ludwig, Simone

    diseases. They grow at different rates and respond to different treatments. That is why people with cancer need treatment that is aimed at their kind of cancer. Therefore, it is important to identify the type of cancer accurately, so that the correct treatment can be started. Breast cancer is a cancer that starts

  3. Estimating radiogenic cancer risks

    SciTech Connect (OSTI)

    NONE

    1994-06-01T23:59:59.000Z

    This document presents a revised methodology for EPA`s estimation of cancer risks due to low-LET radiation exposures in light of information that has become available since the publication of BIER III, especially new information on the Japanese atomic bomb survivors. For most cancer sites, the risk model is one in which the age-specific relative risk coefficients are obtained by taking the geometric mean of coefficients derived from the atomic bomb survivor data employing two different methods for transporting risks from Japan to the U.S. (multiplicative and NIH projection methods). Using 1980 U.S. vital statistics, the risk models are applied to estimate organ-specific risks, per unit dose, for a stationary population.

  4. Modeling Prostate Cancer Detection Probability, with Applications

    E-Print Network [OSTI]

    Serfling, Robert

    investigating causes and treatments. Robert Serfling Modeling Prostate Cancer Detection Probability cancer present as well as tumor nodule sizes, to judge clinical significance before treatment selectionModeling Prostate Cancer Detection Probability, with Applications Robert Serfling1 University

  5. Erysipelas after breast cancer treatment (26 cases)

    E-Print Network [OSTI]

    2005-01-01T23:59:59.000Z

    Erysipelas after breast cancer treatment. Tunis Med, 2002 ,after breast cancer treatment (26 cases) A Masmoudi 1 , Iof 5.23 years after cancer treatment (3 months to 15 years)

  6. Could You Cure Cancer? Alastair M Thompson

    E-Print Network [OSTI]

    Greenaway, Alan

    Could You Cure Cancer? Alastair M Thompson Professor of Surgical Oncology, University of Dundee a.m.thompson ............................could YOU cure cancer? Some questions on cancer: #12;a.m.thompson @ dundee.ac.uk #12;

  7. Cancer Therapies: A Bane and a Boon

    E-Print Network [OSTI]

    Neogi, Sushrita

    2012-01-01T23:59:59.000Z

    on the surgical decision-making process for breast cancer.Cancer, 112(3), 489-494. 2. Grealy, Lucy (1994).Mifflin. 3. He, Lin (2011). Cancer Therapy. [PowerPoint

  8. Diet, MicroRNAs and Prostate Cancer

    E-Print Network [OSTI]

    Saini, Sharanjot; Majid, Shahana; Dahiya, Rajvir

    2010-01-01T23:59:59.000Z

    deregulation in human cancer. Cell Cycle. 2008;7:2643–6. 25.genomic regions involved in cancers. Proc Natl Acad Sci USA.A, Jacks T. MicroRNAs and cancer: short RNAs go a long way.

  9. Childhood Cancer Tracking Initiative in Massachusetts

    E-Print Network [OSTI]

    Childhood Cancer Tracking Initiative in Massachusetts: Developing a New Electronic Tool Presented (CEH) Massachusetts Department of Public Health (MDPH) #12;Childhood Cancer Tracking Initiative "Develop methods for linking environmental databases with childhood cancer incidence data to identify

  10. Mathematical Toolkit Unlocks Some Cancer Secrets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mathematical Models Shed New Light on Cancer Mutations Mathematical Models Shed New Light on Cancer Mutations Calculations Run at NERSC Pinpoint Rare Mutants More Quickly November...

  11. Short communication Evidence for fatal

    E-Print Network [OSTI]

    Stockin, Karen

    (Camphuy- sen & Webb 1999), and contact with the water at high dive speeds can be hazardous (Zillmer 2003

  12. Breakthrough: Fighting Cancer with Nanoparticles

    ScienceCinema (OSTI)

    Rozhkova, Elena

    2013-04-19T23:59:59.000Z

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  13. Breakthrough: Fighting Cancer with Nanoparticles

    SciTech Connect (OSTI)

    Rozhkova, Elena

    2012-01-01T23:59:59.000Z

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  14. Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer

    E-Print Network [OSTI]

    Salzman, Daniel

    Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer Society Cancer and Paolo Boffetta, MD, MPH3 In 1994, the International Agency for Research on Cancer (IARC) classified wood dust as a human carcinogen, based on very strong evidence of a carcinogenic risk of sino-nasal cancer

  15. Cancer Immunol Immunother . Author manuscript Anti-HER2 vaccines: new prospects for breast cancer therapy

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Cancer Immunol Immunother . Author manuscript Page /1 18 Anti-HER2 vaccines: new prospects for breast cancer therapy Maha Zohra Ladjemi 1 , William Jacot 2 , Thierry Chard sè 1 , Andr P legriné è 1 cancer accounts for more than 400.000 new cancer cases and more than 130.000 cancer deaths in Europe

  16. Skin cancer is the most com-mon form of cancer in the United

    E-Print Network [OSTI]

    Skin cancer is the most com- mon form of cancer in the United States. Excessive and unprotected exposure to the sun's ultraviolet radiation (UV light) is the primary risk factor for skin cancer. Howev- er, skin cancer is one of the most preventable types of cancer! The damaging and cumulative effects

  17. NON-MELANOMA SKIN CANCER 3. NON-MELANOMA SKIN CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    NON-MELANOMA SKIN CANCER 21 3. NON-MELANOMA SKIN CANCER 3.1. SUMMARY Non-melanoma skin cancer (NMSC their cancer diagnosis. Table 3.1 Summary information for non-melanoma skin cancer in Ireland, 1995 number of cases for both sexes presented in the 70­79 age group. Figure 3.1 Age distribution of non-melanoma

  18. Extinction Models for Cancer Stem Cell Therapy

    E-Print Network [OSTI]

    Sehl, Mary; Zhou, Hua; Sinsheimer, Janet; Lange, Kenneth

    2009-01-01T23:59:59.000Z

    Characterization of acute lymphoblastic leukemia progenitor58], breast cancer [2], acute lymphoblastic leukemia [10],

  19. Extinction Models for Cancer Stem Cell Therapy

    E-Print Network [OSTI]

    Mary Sehl; Hua Zhou; Janet S. Sinsheimer; Kenneth L. Lange

    2011-01-01T23:59:59.000Z

    Characterization of acute lymphoblastic leukemia progenitor58], breast cancer [2], acute lymphoblastic leukemia [10],

  20. BREAST CANCER GROUP WOMEN'S HEALTH INTERDISCIPLINARY

    E-Print Network [OSTI]

    Spence, Harlan Ernest

    BREAST CANCER GROUP May 2009 WOMEN'S HEALTH INTERDISCIPLINARY RESEARCH CENTER [WHIRC] #12;2 Table: Breast Cancer Research and Treatment 4 Basic/Translational Research Carcinogenesis and Signaling Group 5R) Signaling in Breast Cancer 6 NF-B Family of Transcription Factors in Breast Cancer 7 Transgenic Mouse

  1. Contact Details Journeying Beyond Breast Cancer

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    Home About Contact Details Facebook Search Journeying Beyond Breast Cancer making sense of the cancer experience Feeds: Posts Comments Cancer-fighting fountain pen May 20, 2009 by JBBC A research team be used both as a research tool in the development of next-generation cancer treatments

  2. Also in This Issue 2 International Cancer

    E-Print Network [OSTI]

    MĂĽller, Jens-Dominik

    Also in This Issue 2 International Cancer Benchmarking Partnership 3 Improving Staging Information 4 Studying the Care of Older Prostate Cancer Patients (CARDI) 4 The Northern Ireland PSA Database 5 Lung Cancer Resection Rates 5 All Ireland Cancer Atlas 5 CaPPS Update 6 Living With and Beyond Prostate

  3. Making a difference... A National Cancer

    E-Print Network [OSTI]

    Birmingham, University of

    Making a difference... A National Cancer Research Institute (NCRI) Accredited Trials Unit Contacts Cancer Research UK Clinical Trials Unit School of Cancer Sciences University of Birmingham Edgbaston. Funding The CRCTU receives core funding from Cancer Research UK and has successfully obtained project

  4. CANCER RISKS AM I AT RISK?

    E-Print Network [OSTI]

    Hardy, Christopher R.

    CANCER RISKS AM I AT RISK? It is often hard to explain why one person develops cancer and another does not. There are risk factors that could increase a person's likelihood of developing cancer, however, some people may have many of these risk factors and never get cancer. When thinking about your

  5. What Lung Cancer Patients Need to Know

    E-Print Network [OSTI]

    Kaski, Samuel

    What Lung Cancer Patients Need to Know About Bone Health A Publication of The Bone and Cancer Foundation #12;Contents THIS PUBLICATION PROVIDES IMPORTANT INFORMATION ABOUT THE RELATIONSHIP BETWEEN LUNG CANCER AND BONE HEALTH. HOW BONE WORKS (PAGE 2). WHAT LUNG CANCER CAN DO TO BONE (PAGE 2). TREATING BONE

  6. The Cancer Genome Atlas Pan-Cancer analysis project

    E-Print Network [OSTI]

    Lander, Eric S.

    The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a ...

  7. Diabetes and breast cancer : the women's healthy eating & living study

    E-Print Network [OSTI]

    Erickson, Kirsten Diann

    2011-01-01T23:59:59.000Z

    weight after breast cancer treatments: evidence from thestatus), breast cancer treatment history (years sinceto follow less aggressive cancer treatments 33-37 associated

  8. Carbohydrate Intake and Outcomes among Postmenopausal Breast Cancer Survivors /

    E-Print Network [OSTI]

    Emond, Jennifer Ann

    2013-01-01T23:59:59.000Z

    of the primary breast cancer and treatments received overallof the primary cancer and treatments received, only twoduring and after cancer treatment: a guide for informed

  9. Feeding Frenzy: Shark Cartilage as Treatment for Cancer

    E-Print Network [OSTI]

    Saben, Jamie

    1997-01-01T23:59:59.000Z

    Over Shark Cartilage as Cancer Treatment." Journal of thewith shark cartilage as cancer treatment and are especiallyshark cartilage as a cancer treatment, assess the public's

  10. Diffusion MRI Methods for Improved Treatment Monitoring in Breast Cancer

    E-Print Network [OSTI]

    Aliu, Sheye

    2009-01-01T23:59:59.000Z

    2.9 Breast Cancer Treatment . . . . . . . 2.9.1. Localassessing antivascular cancer treatments. Br J Radiol, 2003.imaging, for breast cancer treatment monitoring. To achieve

  11. School Response to Families with Children with Cancer

    E-Print Network [OSTI]

    Nielsen, Shelley Lynn

    2010-01-01T23:59:59.000Z

    Coping with childhood cancer: Where do we go from here?issues in childhood cancer. School Psychology Review, 28(2),2001). Children surviving cancer: Psychosocial adjustment,

  12. Stromal Modulation of Radiation Carcinogenesis in Breast Cancer

    E-Print Network [OSTI]

    Nguyen, David Hiendat Hua

    2011-01-01T23:59:59.000Z

    receptor-negative breast cancer patients. J Clin Invest 120,Triple-Negative Breast Cancer: Distinguishing between Basaland Nonbasal Subtypes. Clin Cancer Res 15, 2302-2310. Reis-

  13. Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    cigarette smoking, and the risk of breast cancer. Cancerand breast cancer risk. JAMA Ambrosone, C.B. , Kropp, S. ,genotypes, and breast cancer risk: pooled analysis and meta-

  14. Cancer prevention for global health: a report from the ASPO International Cancer Prevention Interest Group.

    E-Print Network [OSTI]

    Braithwaite, Dejana; Boffetta, Paolo; Rebbeck, Timothy R; Meyskens, Frank

    2012-01-01T23:59:59.000Z

    Bull 14. WHO. International Agency for Research on Cancer:World Cancer Report. In Stuart BW, Kleihues P, editors.of environmental and occupational cancer. Oncogene 2004;23:

  15. Reassessment of selected factors affecting siting of Nuclear Power Plants

    SciTech Connect (OSTI)

    Davis, R.E.; Hanson, A.L.; Mubayi, V.; Nourbakhsh, H.P.

    1997-02-01T23:59:59.000Z

    Brookhaven National Laboratory has performed a series of probabilistic consequence assessment calculations for nuclear reactor siting. This study takes into account recent insights into severe accident source terms and examines consequences in a risk based format consistent with the quantitative health objectives (QHOs) of the NRC`s Safety Goal Policy. Simplified severe accident source terms developed in this study are based on the risk insights of NUREG-1150. The results of the study indicate that both the quantity of radioactivity released in a severe accident as well as the likelihood of a release are lower than those predicted in earlier studies. The accident risks using the simplified source terms are examined at a series of generic plant sites, that vary in population distribution, meteorological conditions, and exclusion area boundary distances. Sensitivity calculations are performed to evaluate the effects of emergency protective action assumptions on the risk of prompt fatality and latent cancers fatality, and population relocation. The study finds that based on the new source terms the prompt and latent fatality risks at all generic sites meet the QHOs of the NRC`s Safety Goal Policy by margins ranging from one to more than three orders of magnitude. 4 refs., 17 figs., 24 tabs.

  16. Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    late effects of cancer treatments. Retrospective recruitmenteffects associated with cancer treatments. Implications foron the late effects of cancer treatment, due to the growing

  17. RADTRAN3

    SciTech Connect (OSTI)

    Madsen, M.M.; Taylor, J.M.; Ostmeyer, R.M.; Reardon, P.C. (Sandia National Labs., Albuquerque, NM (United States))

    1986-02-01T23:59:59.000Z

    RADTRAN3 is a flexible analytical tool for calculating both the incident-free and accident impacts of transporting radioactive materials. The consequences from incident-free shipments are apportioned among eight population subgroups and can be calculated for several transport modes. The radiological accident risk (probability times consequence summed over all postulated accidents) is calculated in terms of early fatalities, early morbidities, latent cancer fatalities, genetic effects, and economic impacts. Groundshine, ingestion, inhalation, direct exposure, resuspension, and cloudshine dose pathways are modeled to calculate the radiological health risks from accidents. Economic impacts are evaluated based on costs for emergency response, cleanup, evacuation, income loss, and land use. RADTRAN3 can be applied to specific scenario evaluations (individual transport modes or specified combinations), to compare alternative modes or to evaluate generic radioactive material shipments. Unit-risk factors can easily be evaluated to aid in performing generic analyses when several options must be compared with the amount of travel as the only variable.

  18. RADTRAN3. Radioactive Material Transport Risk

    SciTech Connect (OSTI)

    Madsen, M.M.; Taylor, J.M.; Ostmeyer, R.M.; Reardon, P.C. [Sandia National Labs., Albuquerque, NM (United States)

    1986-02-01T23:59:59.000Z

    RADTRAN3 is a flexible analytical tool for calculating both the incident-free and accident impacts of transporting radioactive materials. The consequences from incident-free shipments are apportioned among eight population subgroups and can be calculated for several transport modes. The radiological accident risk (probability times consequence summed over all postulated accidents) is calculated in terms of early fatalities, early morbidities, latent cancer fatalities, genetic effects, and economic impacts. Groundshine, ingestion, inhalation, direct exposure, resuspension, and cloudshine dose pathways are modeled to calculate the radiological health risks from accidents. Economic impacts are evaluated based on costs for emergency response, cleanup, evacuation, income loss, and land use. RADTRAN3 can be applied to specific scenario evaluations (individual transport modes or specified combinations), to compare alternative modes or to evaluate generic radioactive material shipments. Unit-risk factors can easily be evaluated to aid in performing generic analyses when several options must be compared with the amount of travel as the only variable.

  19. The effect of gender on Helicobacter pylori and gastric cancer

    E-Print Network [OSTI]

    Sheh, Alexander

    2011-01-01T23:59:59.000Z

    Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium ...

  20. Serum 25-hydroxyvitamin D and risk of breast cancer

    E-Print Network [OSTI]

    Mohr, Sharif Burgette

    2012-01-01T23:59:59.000Z

    and prevention of breast cancer: pooled analysis. AnticancerBray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA-Cancer J Clin. 2005;55(2):74-108. American Cancer

  1. Clinical Cancer Care Full screening services and diagnostics

    E-Print Network [OSTI]

    Myers, Lawrence C.

    Clinical Cancer Care · Full screening services and diagnostics · Advanced treatments for all forms of cancer · Most frequent cancers at the Cancer Center: Breast 15% Gastrointestinal 13% Skin 17% Lung 13 treatment protocols that link the latest Cancer Center research to clinical care · Familial Cancer Program

  2. Cancer Epidemiol Biomarkers Prev. Author manuscript Diet, cancer, and the lipidome

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Cancer Epidemiol Biomarkers Prev. Author manuscript Page /1 8 Diet, cancer, and the lipidome Bougnoux Philippe 1 * , Giraudeau Bruno 2 , Couet Charles 1 Nutrition, Croissance et Cancer1 INSERM : E211 with the development of breast cancer by delaying its occurrence makes identification of defined molecules a mandatory

  3. Seminars in Cancer Biology 15 (2005) 484493 Dynamics of colorectal cancer

    E-Print Network [OSTI]

    Nowak, Martin A.

    Seminars in Cancer Biology 15 (2005) 484­493 Review Dynamics of colorectal cancer Franziska Michora Abstract Colorectal cancer results from an accumulation of mutations in tumor suppressor genes and oncogenes. An additional defining characteristic of colorectal cancer is its genetic instability. Two main

  4. NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 HCIP class.

    E-Print Network [OSTI]

    Cinabro, David

    NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 by March 1st. Apply online! See website for further details. http://hcip.nci.nih.gov The National Cancer (NIH), is the Federal Government's principal agency for cancer research and training. The NCI

  5. Mabs against Pancreatic cancer Therapeutic antibodies for the treatment of pancreatic cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Mabs against Pancreatic cancer 1 Therapeutic antibodies for the treatment of pancreatic cancer pancreatic cancer inserm-00497886,version1-6Jul2010 Author manuscript, published in "TheScientificWorldJournal (electronic resource) 2010;10:1107-20" DOI : 10.1100/tsw.2010.103 #12;Mabs against Pancreatic cancer 2

  6. Do cancer cells undergo phenotypic switching? The case for imperfect cancer

    E-Print Network [OSTI]

    De Cindio, Fiorella

    Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers Celoria 26, 20133 Milano, Italy. The identification of cancer stem cells in vivo and in vitro relies on specific surface markers that should allow to sort cancer cells in phenotypically distinct subpopulations

  7. Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer

    E-Print Network [OSTI]

    Greenaway, Alan

    Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer Graeme Houston Fluoroscopy 2 #12;Treatments for Cancer Palliative ­ Relief of obstruction ­ Reduce Bleeding ­ Pain Control ­ Avoid complications Disease Modifying 4 #12;Disease Modifying Cancer Treatment In Situ Ablation

  8. Targeting cancer metabolism: a therapeutic window opens

    E-Print Network [OSTI]

    Vander Heiden, Matthew G.

    Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

  9. Hypoxia activated cell signaling receptors in cancer

    E-Print Network [OSTI]

    Lester, Robin D.

    2008-01-01T23:59:59.000Z

    cancer cells MCF-7 and MDA- MB-231. Biomed. Pharmacother.and prevents apoptosis in MDA-MB-231 breast cancer cells. J.Gaithersburg, MD). Cell Culture MDA-MB-468, MDA-MB-435, ZR-

  10. Lgr4 in Breast Cancer Stem Cells

    E-Print Network [OSTI]

    Zeng, Li

    2014-12-11T23:59:59.000Z

    Breast cancer is the most commonly diagnosed cancer among American women. G-protein coupled receptors (GPCR) comprise a huge family protein with almost 800 members. GPCRs sense molecules or other stimuli outside the cell, and activate intracellular...

  11. Genetics and molecular biology of breast cancer

    SciTech Connect (OSTI)

    King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

    1992-12-31T23:59:59.000Z

    This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

  12. Cancer Vulnerabilities Unveiled by Genomic Loss

    E-Print Network [OSTI]

    Nijhawan, Deepak

    Due to genome instability, most cancers exhibit loss of regions containing tumor suppressor genes and collateral loss of other genes. To identify cancer-specific vulnerabilities that are the result of copy number losses, ...

  13. Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

    SciTech Connect (OSTI)

    Boukheris, Houda [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel S. [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stratton, Kayla L. [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States)] [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States); Smith, Susan A.; Weathers, Rita [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hammond, Sue [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States)] [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States); Mertens, Ann C. [Department of Pediatrics, Emory University, Atlanta, Georgia (United States)] [Department of Pediatrics, Emory University, Atlanta, Georgia (United States); Donaldson, Sarah S. [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States)] [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States); Armstrong, Gregory T.; Robison, Leslie L. [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States)] [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States); Neglia, Joseph P. [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States)] [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States); Inskip, Peter D., E-mail: inskippe@mail.nih.gov [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)

    2013-03-01T23:59:59.000Z

    Purpose: To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials: Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results: During the time period of the study, 23 cases of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion: Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies.

  14. Systems Modeling for Prognostic Cancer Biology

    E-Print Network [OSTI]

    Maccabe, Barney

    goal of this research is the development of personalized treatments in cancer, based on the genomic and treatment. A major challenge in contemporary cancer diagnosis and treatment is the development Systems Modeling for Prognostic Cancer Biology Xuefei Wang1 , BaiLian Li2 , Cheryl L. Willman

  15. Breast Cancer Research Finding Answers. Finding Cures.

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

  16. Cancer Epidemiology Population Health Sciences 750

    E-Print Network [OSTI]

    Sheridan, Jennifer

    -01/5/11-1 Cancer Epidemiology Population Health Sciences 750 3 credits When: Spring 2011 (1 Audience: This course is intended for students in health-related disciplines interested in cancer etiology. the unequal burden of cancer among populations and variations across time and geography, 2. the distinctive

  17. Eligibility: Cancer Survivor ages 35-75

    E-Print Network [OSTI]

    Walter, Peter

    Eligibility: · Cancer Survivor ages 35-75 · Patient has completed treatment within last two years for non-metastic solid tumor · Patient's cancer is currently considered stable or in remission · At least. Please contact Missy Buchanan 415-353-7019 for more information. Helen Diller Family Comprehensive Cancer

  18. Upper extremity impairments in women with or without lymphedema following breast cancer treatment

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    following breast cancer treatment Betty Smoot & Josephinefollowing breast cancer treatment, women will demonstratelymphedema. Breast cancer treatments include surgery,

  19. European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version

    E-Print Network [OSTI]

    Boyer, Edmond

    European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version REVIEW Energy balance and cancers M overweight, have been recognized as risk factors for the development of cancers. Human epidemiological

  20. Provider Communication, Self-Reported Health, and Post-Treatment Regret among Young Breast Cancer Survivors

    E-Print Network [OSTI]

    Fernandes-Taylor, Sara

    2010-01-01T23:59:59.000Z

    R. A. (2004). Breast cancer treatment in older women: impactduring and after cancer treatment: an American Cancerlife following prostate cancer treatment. Cancer Invest, 25(

  1. Assessment of the feasibility of a rehabilitation intervention program for breast cancer survivors with cognitive complaints

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    complaints after breast cancer treatments: examining the2012). Breast Cancer Research and Treatment 135 Wefel, J.STUDIES OF CANCER AND CANCER TREATMENT Assessment of the

  2. Colorectal Cancer Video for the Deaf Community: A Randomized Control Trial

    E-Print Network [OSTI]

    Shabaik, Salma; LaHousse, Sheila F.; Branz, Patricia; Gandhi, Visha; Khan, Amir M.; Sadler, Georgia Robins

    2010-01-01T23:59:59.000Z

    cantly more colorectal cancer knowledge than the controlthe Deaf community about colorectal cancer. KeywordsASL . Cancer prevention . Colorectal cancer . Deaf .

  3. Non-carrier-added 186, 188Re labeled 17a-ethynylestradiol : a potential breast cancer imaging and therapy agent

    SciTech Connect (OSTI)

    Fassbender, M. E. (Michael E.); Phillips, Dennis R.; Peterson, E. J. (Eugene J.); Ott, K. C. (Kevin C.); Arterburn, J. B. (Jeffrey B.)

    2001-01-01T23:59:59.000Z

    Receptor-targeted radiopharmaceuticals constitute potential agents for the diagnosis and therapy of cancer. Breast cancer is the most prevalent form of diagnosed cancer in women in the United States, and it accounts for the second highest number of cases of cancer fatalities (1). In Approximately two-thirds of the breast tumors, estrogen and progesterone steroid hormone receptors can be found. Such tumors can often be treated successfully with anti-estrogen hormone therapy (2). Hence, the ability to determine the estrogen receptor (ER) contend of the breast tumor is essential for making the most appropriate choice of treatment for the patient. Along with this diagnostic aspect, steroid-based radiopharmaceuticals with high specific activity offer an encouraging prospect for therapeutic applications: {sup 186,188}Re labeled steroids binding to receptors expressed by cancer cells appear to be potential agents for the irradiation of small to medium-sized tumors. {sup 186}Re has been regarded as an ideal radionuclide for radiotherapy due to its appropriate half-live of 90 h and {beta}-energy of 1.07 MeV. Moreover, the {gamma}-emission of 137 keV that allows in vivo imaging while in therapy is an additional bonus. {sup 188}Re is obtained from a {sup 188}W/{sup 188}Re radionuclide generator system, representing an advantage for availability at radiopharmacy laboratory by daily elution. In addition, {sup 188}Re emits high energy beta particles with an average energy of 769 keV, and the emission of the 155 keV allows simultaneous imaging for biodistribution evaluation in vivo. In order to avoid competitive saturation of the binding sites of the ligand receptor, Re labeled steroids with high specific activity are required, and the removal of all excess unlabeled ligands is mandatory. {sup 188}Re is eluted from a {sup 188}W/{sup 188}Re generator produced and provided by Oak Ridge National Laboratory (3). This paper outlines the solid phase-supported preparation of an n.c.a. [{sup 188}Re]Re-imido estradiol compound. The characteristic feature of the presented route is the simultaneous formation of the steroid-radioisotope linkage and release of the labeled steroid product into solution (4,5). The unlabeled ligand can then be separated by simple filtration.

  4. Digital Tomosynthesis: Advanced Breast Cancer

    E-Print Network [OSTI]

    Fygenson, Deborah Kuchnir

    creating an image. · A newer process, called full field digital mammography uses digital receptors. #12Digital Tomosynthesis: Advanced Breast Cancer Imaging Technique Max Wiedmann #12;Digital Bremsstrahlung, a process in which electrons are accelerated against an anode, causing photons to be fired off

  5. DIESEL et CANCER Dominique Lafon

    E-Print Network [OSTI]

    Boyer, Edmond

    1/5 DIESEL et CANCER Dominique Lafon INERIS (*) De nombreuses questions se posent sur la toxicité des émissions des moteurs diesel. C'est un sujet qui a beaucoup préoccupé les scientifiques ces EMISSIONS DU DIESEL. Avant d'aborder la toxicité des émissions du diesel, un rappel de leur composition est

  6. Cancer Cell Targeting Androgen Receptor

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    in the development of endo- crine therapies targeting estrogen production or ER for both breast cancer treatment targeting of AR, Wnt or HER2 signaling impairs androgen-stimulated tumor cell growth suggesting potential. Therapies targeting HER2 such as trastuzumab are becoming increasingly important in the treatment of HER2

  7. Predictive and therapeutic markers in ovarian cancer

    SciTech Connect (OSTI)

    Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; Fridlyand, Jane; Mills, Gordon B.

    2013-03-26T23:59:59.000Z

    Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

  8. Cancer in Ireland 1994-2004: A comprehensive report

    E-Print Network [OSTI]

    MĂĽller, Jens-Dominik

    Cancer in Ireland 1994-2004: A comprehensive report A report of cancer incidence, mortality AT and Comber H. Cancer in Ireland 1994-2004: A comprehensive report. Northern Ireland Cancer Registry/National Cancer Registry, Ireland; 2009 #12;#12;NICR/NCRI Contents...i Contents Contents

  9. PrincetonUniversity In-Vitro Studies of Cancer

    E-Print Network [OSTI]

    Petta, Jason

    PrincetonUniversity In-Vitro Studies of Cancer Cell Death Due to Hyperthermia C. Barkey1, RUniversity Cancer: Facts and Figures World Wide 10.1 million newly diagnoses/year with ~10% increase 6.2 million deaths are attributed to cancer and its complication each year American Cancer Society 2007 and Le Cancer

  10. High Throughput Analysis of Breast Cancer Specimens on the Grid

    E-Print Network [OSTI]

    cancer accounts for about 30% of all cancers and 15% of all cancer deaths in women in the United States in the United States. Women living in North America have the highest rate of breast cancer in the world [1]. In spite of the increase in the incidence of the disease, the death rates of breast cancer continue

  11. Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1

    E-Print Network [OSTI]

    Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1 2012 INTERNAL USER GUIDE A Guide to the Cancer Research UK electronic Grants Management System (e://egms.cancerresearchuk.org #12;Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 2

  12. Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam

    E-Print Network [OSTI]

    Petta, Jason

    Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam PresentedPresentation Overview What is Synthetic Biology?What is Synthetic Biology? ProjectProject Cancer: Detect and DestroyCancer regeneration Diabetes Cancer therapy Artificial immune system Environmental Biosensing Environmental

  13. Genome Science and Personalized Cancer Treatment

    ScienceCinema (OSTI)

    Joe Gray

    2010-01-08T23:59:59.000Z

    August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  14. age gastric cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tumour marker in patients with gastric cancer. unknown authors 2 The effect of gender on Helicobacter pylori and gastric cancer MIT - DSpace Summary: Gastric cancer is the 2nd...

  15. advanced gastric cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tumour marker in patients with gastric cancer. unknown authors 2 The effect of gender on Helicobacter pylori and gastric cancer MIT - DSpace Summary: Gastric cancer is the 2nd...

  16. aggressive gastric cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tumour marker in patients with gastric cancer. unknown authors 2 The effect of gender on Helicobacter pylori and gastric cancer MIT - DSpace Summary: Gastric cancer is the 2nd...

  17. Microwave imaging for ultra-wideband antenna based cancer detection 

    E-Print Network [OSTI]

    Zhang, Haoyu

    2015-06-29T23:59:59.000Z

    Breast cancer is one of the most widespread types of cancer in the world. The key factor in treatment is to reliably diagnose the cancer in the early stages. Moreover, currently used clinical diagnostic methods, such as ...

  18. The genomic complexity of primary human prostate cancer

    E-Print Network [OSTI]

    Carter, Scott Lambert

    Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence ...

  19. Perspectives on the mesenchymal origin of metastatic cancer

    E-Print Network [OSTI]

    Huysentruyt, Leanne C.; Seyfried, Thomas N.

    2010-01-01T23:59:59.000Z

    of metastasis. Nature Reviews Cancer, 9(4), 239–252. 12.M. , & Kovarik, J. (1987). Is cancer a macrophage- mediatedof secondary growths in cancer of the breast. Lancet, 1,

  20. Modern mathematics for modern cancer medicine ACC Coolen, July 2013 Modern Mathematics for Modern Cancer Medicine

    E-Print Network [OSTI]

    Coolen, ACC "Ton"

    by developing advanced quantitative techniques, and applying them to cancer data analysis, outcome and treatment individual treatment response, and low success rates of medical trials. To extend and save lives of cancer of good or poor cancer outcomes, of response to specific treatments, or of metastasis sites. Unfortunately

  1. Nutrition and Cancer 1998, 32 (3) 165 NUTRITION AND CANCER 1998, 32 (3),165-173.

    E-Print Network [OSTI]

    Boyer, Edmond

    or processed meat is associated with increased risk of colon cancer. In contrast, consumption of white meat supplied by 1) lard and casein, 2) olive oil and casein, 3) beef, 4) chicken with skin, and 5) bacon. Meat, France. Introduction Colorectal cancer is the second most common cause of death from cancer

  2. Prostate cancer remains the most common cancer in men in the United States, with an

    E-Print Network [OSTI]

    Cai, Long

    Prostate cancer remains the most common cancer in men in the United States, with an estimated of death from cancer in men, with 33,720 estimated deaths (11% of all estimated deaths) in 2011 (REF. 1-year relative survival rate is essentially 100% based on 2001­2007 statistics2 . However, for patients

  3. The National Cancer Survivorship Initiative: new and emerging evidence on the ongoing needs of cancer survivors

    E-Print Network [OSTI]

    Quartly, Graham

    ; #12; A key commitment of the Cancer Reform Strategy (Department of Health, 2007) in UK, and endorsed Floor Portland House, Bressenden Place, London SW1E 5RS, UK; 2 Faculty of Health Sciences, University in Improving Outcomes Strategy for Cancer (Department of Health, 2011), was to establish a National Cancer

  4. Eur J Cancer Prev. Author manuscript Determinants of non-compliance to recommendations on breast cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Eur J Cancer Prev. Author manuscript Page /1 11 Determinants of non-compliance to recommendations on breast cancer screening among women participating in the French E3N cohort study Flamant Camille , Gauthier Estelle , Clavel-Chapelon Fran oiseç * E3N, Nutrition, hormones et cancer: pid miologie et pr

  5. J. Clairambault Theorems to treat cancer? Can theorems help treat cancer?

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    J. Clairambault Theorems to treat cancer? Can theorems help treat cancer? Jean Clairambault 1 INRIA who treat patients with can- cer? Can mathematics have an impact on cancer biology? Is mathematics more than just a tool in the hands of [a few open-minded] physicians willing to understand and treat

  6. Cutaneous cancers in Calabar, Southern Nigeria

    E-Print Network [OSTI]

    Asuquo, Maurice E; Ebughe, Godwin

    2009-01-01T23:59:59.000Z

    Skin cancer in Zaria, Nigeria. Trop Doct 1995; 25(Suppl. ):Malignancies in Kano, Northern Nigeria: A histopathologicalequatorial rain forest of Nigeria. International Journal of

  7. Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    quality of life among long-term survivors of breast cancer.Breast Cancer Res Treat. 1996;39(3):261–73. doi:B, Bower JE. Breast Cancer in Younger Women: Reproductive

  8. This issue of the Stanford Cancer Institute Clinical Research Newsletter is focused on our multi-disciplinary Women's Cancer and Urologic Cancer Programs.

    E-Print Network [OSTI]

    Sonnenburg, Justin L.

    's cancer. In addition to cancer treatment, supportive services--including social services, psychological of the triple negative breast cancer. The Stanford Gynecologic Oncology Program offers treatments and clinical Group (COGi), a national cooperative research group for innovative treatments in ovarian cancer

  9. advanced colon cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    from multiple specialties work together under Engineering Websites Summary: BREAST CANCER PROGRAM A team of breast cancer experts from multiple specialties work together under...

  10. Isotope production facility produces cancer-fighting actinium

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer therapy gets a boost from new isotope Isotope production facility produces cancer-fighting actinium A new medical isotope project shows promise for rapidly producing major...

  11. Sensitive Immunosensor for Cancer Biomarker Based on Dual Signal...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Immunosensor for Cancer Biomarker Based on Dual Signal Amplification Strategy of Graphene Sheets and Multi-Enzyme Sensitive Immunosensor for Cancer Biomarker Based on Dual Signal...

  12. Endoscopic Electron-Beam Cancer Therapy | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Endoscopic Electron-Beam Cancer Therapy Technology available for licensing: A successful and cost-effective means of treating cancer in previously inoperable or radiation-sensitive...

  13. DOE Laboratories Help Develop Promising New Cancer Fighting Drug...

    Office of Environmental Management (EM)

    Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm...

  14. Proteogenomic characterization of human colon and rectal cancer...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    characterization of human colon and rectal cancer. Proteogenomic characterization of human colon and rectal cancer. Abstract: We analyzed proteomes of colon and rectal tumors...

  15. Biocompatible core-shell magnetic nanoparticles for cancer treatment...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biocompatible core-shell magnetic nanoparticles for cancer treatment. Biocompatible core-shell magnetic nanoparticles for cancer treatment. Abstract: Non-toxic magnetic...

  16. Blood Peptidome-Degradome Profile of Breast Cancer. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Blood Peptidome-Degradome Profile of Breast Cancer. Blood Peptidome-Degradome Profile of Breast Cancer. Abstract: We report on the degradomic-peptidomic insights into blood plasma...

  17. Searching for a system: The quest for ovarian cancer biomarkers...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Searching for a system: The quest for ovarian cancer biomarkers. Searching for a system: The quest for ovarian cancer biomarkers. Abstract: The stark difference in clinical outcome...

  18. advanced bladder cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer Mortality Kenneth G. Brown; Barbara D. Beck; Claudia Hopenhayn-Rich; Mary Lou Biggs; Allan H. Smith Biology and Medicine Websites Summary: Arsenic and Bladder Cancer...

  19. adult cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer Center's Adult Patient & Family Advisory Council Page 1 of 3 and compassionate health care provided by Dana-FarberBrigham and Women's Cancer Center. Working in active...

  20. Nanotechnology in Cancer Treatment and Detection Richard Acosta

    E-Print Network [OSTI]

    Fygenson, Deborah Kuchnir

    Nanotechnology in Cancer Treatment and Detection Richard Acosta #12;Motivation ·Ineffectiveness or roughly 100 times smaller than most human cells Cancer Nanotechnology research is interdisciplinary

  1. Transportation impact analysis for shipment of irradiated N-reactor fuel and associated materials

    SciTech Connect (OSTI)

    Daling, P.M.; Harris, M.S.

    1994-12-01T23:59:59.000Z

    An analysis of the radiological and nonradiological impacts of highway transportation of N-Reactor irradiated fuel (N-fuel) and associated materials is described in this report. N-fuel is proposed to be transported from its present locations in the 105-KE and 105-KW Basins, and possibly the PUREX Facility, to the 327 Building for characterization and testing. Each of these facilities is located on the Hanford Site, which is near Richland, Washington. The projected annual shipping quantity is 500 kgU/yr for 5 years for a total of 2500 kgU. It was assumed the irradiated fuel would be returned to the K- Basins following characterization, so the total amount of fuel shipped was assumed to be 5000 kgU. The shipping campaign may also include the transport and characterization of liquids, gases, and sludges from the storage basins, including fuel assembly and/or canister parts that may also be present in the basins. The impacts of transporting these other materials are bounded by the impacts of transporting 5000 kgU of N-fuel. This report was prepared to support an environmental assessment of the N-fuel characterization program. The RADTRAN 4 and GENII computer codes were used to evaluate the radiological impacts of the proposed shipping campaign. RADTRAN 4 was used to calculate the routine exposures and accident risks to workers and the general public from the N-fuel shipments. The GENII computer code was used to calculate the consequences of the maximum credible accident. The results indicate that the transportation of N-fuel in support of the characterization program should not cause excess radiological-induced latent cancer fatalities or traffic-related nonradiological accident fatalities. The consequences of the maximum credible accident are projected to be small and result in no excess latent cancer fatalities.

  2. Drug-drug similarity networks for anti-cancer drug discovery Case studies on Breast Cancer, Colorectal Cancer and Leukemia

    E-Print Network [OSTI]

    Zhou, Yaoqi

    Drug-drug similarity networks for anti-cancer drug discovery ­ Case studies on Breast Cancer the decades, the medical industry has been challenged with the issue of producing drugs that would avoid sidetracking to other targets (off-targets) and keep away from harmful side effects (drug adverse reactions

  3. Early Growth Response 3 (Egr3) Is Highly Over-Expressed in Non-Relapsing Prostate Cancer but Not in Relapsing Prostate Cancer

    E-Print Network [OSTI]

    Pio, Rebecca; Jia, Zhenyu; Baron, Veronique T; Mercola, Dan; Agoulnik, Irina U

    2013-01-01T23:59:59.000Z

    company developing prostate cancer related tests. Dr. Barontherapy for prostate cancer. There are no marketed productsand prognosis of prostate cancer. September 2011: US

  4. Bayesian Nonparametric Latent Feature Models

    E-Print Network [OSTI]

    Miller, Kurt Tadayuki

    2011-01-01T23:59:59.000Z

    1(2):353–355, 1973. David M. Blei and Michael I. Jordan.D. Hoffman, David M. Blei, and Perry R. Cook. BayesianEdoardo M. Airoldi, David M. Blei, Eric P. Xing, and Stephen

  5. ARM - Measurement - Latent heat flux

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadap Documentation TDMADAP : XDC documentationBarrow,ice particleSizegovMeasurementsIsotope

  6. Cell and nanomaterial-based approaches for diagnosis and chemotherapy of metastatic cancer cells

    E-Print Network [OSTI]

    Kohli, Aditya (Aditya Gobind)

    2010-01-01T23:59:59.000Z

    Metastasis is a multistep process during which tumor cells separate from a primary tumor, penetrate the bloodstream, evade host defenses, and colonize distant organs. This final and fatal step in tumor development is the ...

  7. Diet and Cancer Are Cooked Meats Involved

    ScienceCinema (OSTI)

    LLNL - University of California Television

    2009-09-01T23:59:59.000Z

    Diet has been associated with differences in cancer rates in human populations for many years. Mark Knize presents the latest research on cancer causes including work performed at Lawrence Livermore National Laboratory investigating some interesting chemical products created when meat is cooked and how to reduce them. Series: Science on Saturday [10/2006] [Health and Medicine] [Science] [Show ID: 11542

  8. EDITORIAL Open Access Toward integrative cancer immunotherapy

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    alterations of normal host cells. Accordingly, the aim of most traditional cancer therapies has been to destroy the transformed cells themselves. There is now widespread appreciation that the progressive growth and metastatic spread of cancer cells requires the cooperation of normal host cells (endothelial cells

  9. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, M.J.; Weaver, V.M.

    1998-12-08T23:59:59.000Z

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying {beta}{sub 1} integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive. 14 figs.

  10. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

    1998-01-01T23:59:59.000Z

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

  11. A RE-LOOK AT THE US NRC SAFETY GOALS

    SciTech Connect (OSTI)

    mubayi v.

    2013-09-22T23:59:59.000Z

    Since they were adopted in 1986, the US NRC’s Safety Goals have played a valuable role as a de facto risk acceptance criterion against which the predicted performance of a commercial nuclear power reactor can be evaluated and assessed. The current safety goals are cast in terms of risk metrics called quantitative health objectives (QHOs), limiting numerical values of the risks of the early and latent health effects of accidental releases of radioactivity to the offsite population. However, while demonstrating compliance with current safety goals has been an important step in assessing the acceptance of the risk posed by LWRs, new or somewhat different goals may be needed that go beyond the current early fatality and latent cancer fatality QHOs in assessing reactor risk. Natural phenomena such as hurricanes seem to be suitable candidates for establishing a background rate to derive a risk goal as their order of magnitude cost of damages is similar to those estimated in severe accident Level 3 PRAs done for nuclear power plants. This paper obtains a risk goal that could have a wider applicability, compared to the current QHOs, as a technology-neutral goal applicable to future reactors and multi-unit sites.

  12. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three US population-based case-control studies of ovarian cancer

    SciTech Connect (OSTI)

    Whittemore, A.S.; Gong, G.; Itnyre, J. [Stanford Univ. School of Medicine, CA (United States)

    1997-03-01T23:59:59.000Z

    We investigate the familial risks of cancers of the breast and ovary, using data pooled from three population-based case-control studies of ovarian cancer that were conducted in the United States. We base estimates of the frequency of mutations of BRCA1 (and possibly other genes) on the reported occurrence of breast cancer and ovarian cancer in the mothers and sisters of 922 women with incident ovarian cancer (cases) and in 922 women with no history of ovarian cancer (controls). Segregation analysis and goodness-of-fit testing of genetic models suggest that rare mutations (frequency .0014; 95% confidence interval .0002-.011) account for all the observed aggregation of breast cancer and ovarian cancer in these families. The estimated risk of breast cancer by age 80 years is 73.5% in mutation carriers and 6.8% in noncarriers. The corresponding estimates for ovarian cancer are 27.8% in carriers and 1.8% in noncarriers. For cancer risk in carriers, these estimates are lower than those obtained from families selected for high cancer prevalence. The estimated proportion of all U.S. cancer diagnoses, by age 80 years, that are due to germ-line BRCA1 mutations is 3.0% for breast cancer and 4.4% for ovarian cancer. Aggregation of breast cancer and ovarian cancer was less evident in the families of 169 cases with borderline ovarian cancers than in the families of cases with invasive cancers. Familial aggregation did not differ by the ethnicity of the probands, although the number of non-White and Hispanic cases (N = 99) was sparse. 14 refs., 3 figs., 6 tabs.

  13. The use of complementary and alternative medicine among breast cancer survivors : the women's healthy eating and living study perspective

    E-Print Network [OSTI]

    Saquib, Juliann

    2010-01-01T23:59:59.000Z

    disparities in breast cancer treatment. J Clin Oncol 2007;based trends in cancer treatment. J Natl Cancer Inst 2005;use systemic cancer treatments across tumor characteristics

  14. Contacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit

    E-Print Network [OSTI]

    Birmingham, University of

    treatments and biomarkers for cancer. The CRCTU also collaborate with a large number of academic scientificContacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit School of Cancer Sciences University://www.birmingham.ac.uk/crctu Making a difference... A National Cancer Research Institute Accredited Trials Unit Linked Groups

  15. Contacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit

    E-Print Network [OSTI]

    Birmingham, University of

    scientists in the development of new treatments and biomarkers for cancer. The CRCTU also collaborateContacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit School of Cancer Sciences University... A National Cancer Research Institute Accredited Trials Unit Linked Groups @CRCTUCRCTU Birmingham

  16. Cancer is a genetic disease1 . Although environmental

    E-Print Network [OSTI]

    Nowak, Martin A.

    Cancer is a genetic disease1 . Although environmental and other non-genetic factors have roles in many stages of tumorigenesis,it is widely accepted that cancer arises because of mutations in cancer,however,does not suffice to give rise to full-blown cancer.For progression towards malignancyandinvasion

  17. Metabolism and proliferation share common regulatory pathways in cancer

    E-Print Network [OSTI]

    Boyer, Edmond

    Metabolism and proliferation share common regulatory pathways in cancer cells. Vanessa Fritz, proliferation, and cancer inserm-00491405,version1-11Jun2010 Author manuscript, published in "Oncogene 2010;29(31):4369-77" DOI : 10.1038/onc.2010.182 #12;Metabolism, proliferation and cancer Fritz and Fajas 2 Abstract Cancer

  18. Cancer Cells DOI: 10.1002/anie.201103189

    E-Print Network [OSTI]

    Zhang, Liangfang

    Cancer Cells DOI: 10.1002/anie.201103189 Self-Propelled Microrockets to Capture and Isolate Circulating Tumor Cells Weiwei Gao and Omid C. Farokhzad* cancer · micromachines · nanorobots · nanotechnology metastatic cancer.[1] Since then cancer research has proved the critical roles played by CTC

  19. lung cancer smoke-free 6 One man's

    E-Print Network [OSTI]

    Roy, Subrata

    Fighting lung cancer Living smoke-free 6 One man's mission85 #12;Cure is the newsletter for the University of Florida Shands Cancer Center, home to cancer care and research for the Southeast's most? For more information about care and services offered at the UF Shands Cancer Center, call 352

  20. "Skin Cancer-What to Look For" Rochester Recreation

    E-Print Network [OSTI]

    Goldman, Steven A.

    "Skin Cancer- What to Look For" Rochester Recreation Club for the Deaf May 20, 2010 #12;Supporters for the Deaf ("REAP") #12;Overview Skin Overview What is skin cancer? Who is at risk? How common is skin cancer? Signs of skin cancer Prevention Treatments #12;Skin Overview Skin is the largest organ in your body

  1. Cancer Cells DOI: 10.1002/anie.201100115

    E-Print Network [OSTI]

    Zhang, Liangfang

    Cancer Cells DOI: 10.1002/anie.201100115 Micromachine-Enabled Capture and Isolation of Cancer Cells (CTCs) are the primary entities responsible for spawning cancer metastasis. Detection of CTCs provides an indicator for the clinical diagnosis and prognosis of various types of cancers. Several approaches, based

  2. SUPPLEMENTAL FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER

    E-Print Network [OSTI]

    Sibille, Etienne

    SUPPLEMENTAL FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER Sponsored by: The Specialized Program of Research Excellence (SPORE) in Melanoma & Skin Cancer University of Pittsburgh Cancer Institute Purpose The overall goals of the Melanoma & Skin Cancer SPORE are to improve the detection

  3. FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER

    E-Print Network [OSTI]

    Sibille, Etienne

    FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER Sponsored by: The Specialized Program of Research Excellence (SPORE) in Melanoma & Skin Cancer University of Pittsburgh Cancer Institute (UPCI) Purpose The overall goals of the Melanoma & Skin Cancer SPORE are to improve the detection

  4. IN A CUREUF HEALTH CANCER CENTER NEWS SPRING 2014

    E-Print Network [OSTI]

    Roy, Subrata

    care and research for the Southeast's most comprehensive academic health center. In each issue, weIN A CUREUF HEALTH CANCER CENTER NEWS Believe SPRING 2014 PAGE6 #12;www.cancer.ufl.eduBelieve in a Cure//Spring 20142 Believe in a Cure is the newsletter for the UF Health Cancer Center, home to cancer

  5. AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention

    E-Print Network [OSTI]

    Kaski, Samuel

    AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention What are the chances that I will develop lung cancer? The #1 cause of lung cancer is exposure to tobacco smoke. Your chances increase others (second-hand smoke), the greater your chances of developing lung cancer. People who have never

  6. Radio Sensors to Help Detect Cancer Monday, July 28, 2008 -Anni Shaer Levitt

    E-Print Network [OSTI]

    Chiao, Jung-Chih

    , Treatments & Facts on Breast Cancer Cancers Acid Reflux Causes Cancer A free, informative online video.RefluxRemedy.com American Cancer Society Get the latest information on stomach cancer treatments www.cancerSearch Home Headlines News Articles Forums Radio Sensors to Help Detect Cancer Monday, July 28

  7. An online survey to find out how people manage cancer and cancer related problems in the 12

    E-Print Network [OSTI]

    Anderson, Jim

    following initial cancer treatment There are around two million people in the UK living with or beyond cancer and this number is rising by more than 3% per year. Treatments for cancer such as chemotherapy manage most problems associated with cancer and its treatment on their own as part of their daily lives

  8. Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal cell to a malignant one

    E-Print Network [OSTI]

    Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal regulators of growth. Biomarkers associated with cancer were examined in human breast epithelial cells transformed by high-LET radiation in the presence of 17Ă?-estradiol. An established cancer model was used

  9. doi:10.1016/j.ijrobp.2006.02.044 INDUCED SECOND CANCERS AFTER PROSTATE-CANCER

    E-Print Network [OSTI]

    Brenner, David Jonathan

    doi:10.1016/j.ijrobp.2006.02.044 EDITORIAL INDUCED SECOND CANCERS AFTER PROSTATE-CANCER University Medical Center, New York, NY The absolute risks of a radiation-induced second cancer among long concern, expressed by Kendal et al. (5) in this issue, that prostate cancer patients may be unduly

  10. Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

    E-Print Network [OSTI]

    Wahl, Geoffrey M.

    Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Hospital for Sick Children, Toronto, Ontario, Canada; 4 Terry Fox Laboratory BC Cancer Research Center, Vancouver, British Columbia, Canada; 5 Moores University of California San Diego Cancer Center; 6 The Salk

  11. A Framework for Developing, Implementing, and Evaluating a Cancer Survivorship Curriculum for Medical Students

    E-Print Network [OSTI]

    Uijtdehaage, Sebastian; Hauer, Karen E.; Stuber, Margaret; Rajagopalan, Shobita; Go, Vay L.; Wilkerson, LuAnn

    2009-01-01T23:59:59.000Z

    the impact of cancer and treatment on their relation- ships,term consequences of cancer treatments. Furthermore, whileincluding details of cancer treatment and follow-up. In

  12. Cancer survivors and survivorship care: Provider expectations, post-treatment health services, and patient reported outcomes

    E-Print Network [OSTI]

    Hahn, Erin Elizabeth

    2013-01-01T23:59:59.000Z

    you heard about cancer treatment summaries or survivorshipthe course of breast cancer treatment should patients beginduring their active cancer treatment (surgery, radiation,

  13. Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts

    E-Print Network [OSTI]

    Kelly, KM; Dean, J; Comulada, WS; Lee, S-J

    2010-01-01T23:59:59.000Z

    at high risk for breast cancer with MR imaging. Breast Can-Findings from the Breast Cancer Surveillance Consortium:women undergoing biopsy after screening mammography. Cancer

  14. Lung Cancer as a Second Primary Malignancy: Increasing Prevalence and Its Influence on Survival

    E-Print Network [OSTI]

    Quadrelli, Silvia; Lyons, Gustavo; Colt, Henri; Chimondeguy, Domingo; Silva, Carlos

    2009-01-01T23:59:59.000Z

    therapy for multiple primary lung cancers. Chest. REFERENCEMR. Multiple primary lung cancers. J Thorac Cardiovasc Surg.606–12. 2. Johnson BE. Second lung cancers in patients after

  15. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    Molecular pathogenesis of lung cancer,” Annual Review ofp63 immunoreac- tivity in lung cancer: yet another player inprotein-related genes in lung cancer: correlation with drug

  16. advanced head-and-neck cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in skin cancer, colorectal carcinoma, testicular teratoma and liver cancer types: brain, breast, head and neck, renal, skin and testicular cancers. Conclusions: SULF1 and...

  17. Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

    E-Print Network [OSTI]

    Fendt, Sarah-Maria

    Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin; however, the mechanism by which metformin improves cancer ...

  18. Fatal Metformin Overdose Presenting with Progressive Hyperglycemia

    E-Print Network [OSTI]

    Suchard, Jeffrey R; Grotsky, Thomas A

    2008-01-01T23:59:59.000Z

    Weilemann LS. Experiences of a poison center with metformin-exposures reported to U.S. poison control centers, only 4072exposures reported to poison control centers, but only 10%

  19. Nanoparticles and amyloid systems: A fatal encounter?

    SciTech Connect (OSTI)

    Abel, Bernd [Leibniz Institute of Surface Modification, Chemical Department, Permoserstr. 15, D-04318 Leipzig, Germany and Wilhelm-Ostwald-Institute for Physical and Theoretical Chemistry, Linnéstr. 3, D-04103 Leipzig (Germany)

    2014-10-06T23:59:59.000Z

    Nanoparticles (NPs) are used in many products of our daily life, however, there has been concern that they may also be harmful to human health. Recently NPs have been found to accelerate the fibrillation kinetics of amyloid systems. In the past this has been preliminarily attributed to a nucleation effect. Nanoparticle surfaces and interfaces appear to limit the degrees of freedom of amyloid systems (i.e., peptides and proteins) due to a phase space constraint such that rapid cross-beta structures are formed faster than without interface interactions and in turn fibril formation is enhanced significantly. Here we explore if lipid bilayers in the form of liposomes (140nm) also accelerate fibril formation for amyloid systems. We have investigated a fragment NNFGAIL of the Human islet amyloid polypeptide (hIAPP) in contact with 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) liposomes in aqueous solution. We found that the lipid bilayer vesicles do accelerate fibril formation in time-resolved off-line detected atomic force microscopy experiments. Characteristic Thioflavine-T fluorescence on the same structures verify that the structures consist of aggregated peptides in a typical cross-?-structure arrangement.

  20. Micro and nanotechnology for cancer treatment

    E-Print Network [OSTI]

    Ullal, Adeeti (Adeeti Vedantham)

    2013-01-01T23:59:59.000Z

    Cancer is responsible for over 7.6 million deaths worldwide; the majority of patients fail to respond to drugs or become resistant over time. In order to gain a better understanding of drug efficacy in patients, we developed ...

  1. Near infrared optical lymphography for cancer diagnostics

    E-Print Network [OSTI]

    Houston, Jessica Perea

    2007-04-25T23:59:59.000Z

    A new molecular imaging modality has been developed to detect and locate positive axillary and sentinel lymph nodes non-invasively in breast cancer patients undergoing lymphoscintigraphy. The modality is based on fluorescent photon detection...

  2. Intestinal cancer : linking infection, inflammation and neoplasia

    E-Print Network [OSTI]

    Sohn, Jane Joo-hee, 1976-

    2005-01-01T23:59:59.000Z

    Cancer is a leading cause of death in the world. Much work has been done to study the role of inflammation in carcinogenesis. One hypothesis suggests that inflammation causes oxidative stress that induces damage to cellular ...

  3. Breast Density and Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Breast Cancer Awareness Series: Understanding Breast Density Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in...

  4. Investigation into taxane resistant breast cancer 

    E-Print Network [OSTI]

    Kenicer, Juliet Elisabeth Margaret

    2011-11-25T23:59:59.000Z

    One group of chemotherapeutics that are used successfully to treat breast cancer, alone or in combination with other agents, are the taxanes; paclitaxel and docetaxel. They act by interfering with the spindle microtubule ...

  5. Regulatory roles of endothelial cells in cancer

    E-Print Network [OSTI]

    Franses, Joseph W. (Joseph Wang)

    2011-01-01T23:59:59.000Z

    This thesis describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view ...

  6. Focus on the Physics of Cancer

    E-Print Network [OSTI]

    Risler, Thomas

    2015-01-01T23:59:59.000Z

    Despite the spectacular achievements of molecular biology in the second half of the twentieth century and the crucial advances it permitted in cancer research, the fight against cancer has brought some disillusions. It is nowadays more and more apparent that getting a global picture of the very diverse and interlinked aspects of cancer development necessitates, in synergy with these achievements, other perspectives and investigating tools. In this undertaking, multidisciplinary approaches that include quantitative sciences in general and physics in particular play a crucial role. This `focus on' collection contains 19 articles representative of the diversity and state-of-the-art of the contributions that physics can bring to the field of cancer research.

  7. Cancer Cell Metabolism: One Hallmark, Many Faces

    E-Print Network [OSTI]

    Sabatini, David M.

    Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly ...

  8. Regulation of apoptosis in human cancer cells

    E-Print Network [OSTI]

    Lloyd, S. Julie-Ann (Simone Julie-Ann)

    2005-01-01T23:59:59.000Z

    Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis ...

  9. Somatic retrotransposition in the cancer genome

    E-Print Network [OSTI]

    Helman, Elena

    2014-01-01T23:59:59.000Z

    Cancer is a complex disease of the genome exhibiting myriad somatic mutations, from single nucleotide changes to various chromosomal rearrangements. The technological advances of next-generation sequencing enable high-throughput ...

  10. Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer

    SciTech Connect (OSTI)

    Spellman, Paul T.; Heiser, Laura; Gray, Joe W.

    2009-06-18T23:59:59.000Z

    Breast cancer is predominantly a disease of the genome with cancers arising and progressing through accumulation of aberrations that alter the genome - by changing DNA sequence, copy number, and structure in ways that that contribute to diverse aspects of cancer pathophysiology. Classic examples of genomic events that contribute to breast cancer pathophysiology include inherited mutations in BRCA1, BRCA2, TP53, and CHK2 that contribute to the initiation of breast cancer, amplification of ERBB2 (formerly HER2) and mutations of elements of the PI3-kinase pathway that activate aspects of epidermal growth factor receptor (EGFR) signaling and deletion of CDKN2A/B that contributes to cell cycle deregulation and genome instability. It is now apparent that accumulation of these aberrations is a time-dependent process that accelerates with age. Although American women living to an age of 85 have a 1 in 8 chance of developing breast cancer, the incidence of cancer in women younger than 30 years is uncommon. This is consistent with a multistep cancer progression model whereby mutation and selection drive the tumor's development, analogous to traditional Darwinian evolution. In the case of cancer, the driving events are changes in sequence, copy number, and structure of DNA and alterations in chromatin structure or other epigenetic marks. Our understanding of the genetic, genomic, and epigenomic events that influence the development and progression of breast cancer is increasing at a remarkable rate through application of powerful analysis tools that enable genome-wide analysis of DNA sequence and structure, copy number, allelic loss, and epigenomic modification. Application of these techniques to elucidation of the nature and timing of these events is enriching our understanding of mechanisms that increase breast cancer susceptibility, enable tumor initiation and progression to metastatic disease, and determine therapeutic response or resistance. These studies also reveal the molecular differences between cancer and normal that may be exploited to therapeutic benefit or that provide targets for molecular assays that may enable early cancer detection, and predict individual disease progression or response to treatment. This chapter reviews current and future directions in genome analysis and summarizes studies that provide insights into breast cancer pathophysiology or that suggest strategies to improve breast cancer management.

  11. Radiation Dose and Subsequent Risk for Stomach Cancer in Long-term Survivors of Cervical Cancer

    SciTech Connect (OSTI)

    Kleinerman, Ruth A., E-mail: kleinerr@mail.nih.gov [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Holowaty, Eric [Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario (Canada); Hall, Per [Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm (Sweden); Pukkala, Eero [Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki (Finland); Vaalavirta, Leila [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Stovall, Marilyn; Weathers, Rita [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Aleman, Berthe M.P. [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands); Kaijser, Magnus [Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm (Sweden); Andersson, Michael [Department of Oncology, Copenhagen University Hospital, Copenhagen (Denmark); Storm, Hans [Cancer Prevention and Documentation, Danish Cancer Society, Copenhagen (Denmark); Joensuu, Heikki [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, Iowa (United States); and others

    2013-08-01T23:59:59.000Z

    Purpose: To assess the dose–response relationship for stomach cancer after radiation therapy for cervical cancer. Methods and Materials: We conducted a nested, matched case–control study of 201 cases and 378 controls among 53,547 5-year survivors of cervical cancer diagnosed from 1943 to 1995, from 5 international, population-based cancer registries. We estimated individual radiation doses to the site of the stomach cancer for all cases and to corresponding sites for the matched controls (overall mean stomach tumor dose, 2.56 Gy, range 0.03-46.1 and after parallel opposed pelvic fields, 1.63 Gy, range 0.12-6.3). Results: More than 90% of women received radiation therapy, mostly with external beam therapy in combination with brachytherapy. Stomach cancer risk was nonsignificantly increased (odds ratio 1.27-2.28) for women receiving between 0.5 and 4.9 Gy to the stomach cancer site and significantly increased at doses ?5 Gy (odds ratio 4.20, 95% confidence interval 1.41-13.4, P{sub trend}=.047) compared with nonirradiated women. A highly significant radiation dose–response relationship was evident when analyses were restricted to the 131 cases (251 controls) whose stomach cancer was located in the middle and lower portions of the stomach (P{sub trend}=.003), whereas there was no indication of increasing risk with increasing dose for 30 cases (57 controls) whose cancer was located in the upper stomach (P{sub trend}=.23). Conclusions: Our findings show for the first time a significant linear dose–response relationship for risk of stomach cancer in long-term survivors of cervical cancer.

  12. Dana-Farber Cancer Institute About Dana-Farber Cancer Institute

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    ;About the Jimmy Fund The Jimmy Fund raises vital funds to support adult and pediatric cancer care and research at Dana-Farber exclusively. Since 1948, the generosity of millions of people has helped the Jimmy Fund save countless lives and reduce the burden of cancer. The Jimmy Fund has: · raised more than $948

  13. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    of lung cancer,” Clinical Cancer Research, vol. 4, no. 7,pathogenesis of lung cancer,” Annual Review of Physiology,immunoreac- tivity in lung cancer: yet another player in the

  14. Functional Promoter Variant rs2868371 of HSPB1 Is Associated With Risk of Radiation Pneumonitis After Chemoradiation for Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Pang, Qingsong [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States) [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Department of Radiation Oncology and Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin (China); Wei, Qingyi [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States); Xu, Ting [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Yuan, Xianglin [Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan (China)] [Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan (China); Lopez Guerra, Jose Luis [Department of Medicine, Universitat Autňnoma de Barcelona (Spain)] [Department of Medicine, Universitat Autňnoma de Barcelona (Spain); Levy, Lawrence B. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Liu, Zhensheng [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States); Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Zhuang, Yan [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States); Wang, Li-E. [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States); Mohan, Radhe [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States); Komaki, Ritsuko [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)

    2013-04-01T23:59:59.000Z

    Purpose: To date, no biomarkers have been found to predict, before treatment, which patients will develop radiation pneumonitis (RP), a potentially fatal toxicity, after chemoradiation for lung cancer. We investigated potential associations between single nucleotide polymorphisms (SNPs) in HSPB1 and risk of RP after chemoradiation for non-small cell lung cancer (NSCLC). Methods and Materials: Subjects were patients with NSCLC treated with chemoradiation at 1 institution. The training data set comprised 146 patients treated from 1999 to July 2004; the validation data set was 125 patients treated from August 2004 to March 2010. We genotyped 2 functional SNPs of HSPB1 (rs2868370 and rs2868371) from all patients. We used Kaplan-Meier analysis to assess the risk of grade ?2 or ?3 RP in both data sets and a parametric log-logistic survival model to evaluate the association of HSPB1 genotypes with that risk. Results: Grade ?3 RP was experienced by 13% of those with CG/GG and 29% of those with CC genotype of HSPB1 rs2868371 in the training data set (P=.028); corresponding rates in the validation data set were 2% CG/GG and 14% CC (P=.02). Univariate and multivariate analysis confirmed the association of CC of HSPB1 rs2868371 with higher risk of grade ?3 RP than CG/GG after adjustment for sex, age, performance status, and lung mean dose. This association was validated both in the validation data set and with Harrell's C statistic. Conclusions: The CC genotype of HSPB1 rs2868371 was associated with severe RP after chemoradiation for NSCLC.

  15. Sports activities and risk of testicular cancer

    E-Print Network [OSTI]

    A. J. Coldman; J. M. Elwooda; R. P. Gallagher; Nottingham Nottingham

    1982-01-01T23:59:59.000Z

    Summary.-The relationship of testicular seminoma with several factors was explored using a case-control study. Previously recognized associations with cryptorchidism and infantile inguinal hernia were confirmed and relationships were also found with cycling and horse-riding. These findings represent the first relationships of testicular cancer with well-defined postnatal risk factors. TESTICULAR CANCER is now the most common neoplasm in men aged 25-34 in England and Wales (Davies, 1981) and follows only non-melanoma skin cancer in Canada (Statistics Canada, 1980). Mortality in young men has been rising during this century in a number of countries (Davies, 1981; Grumet & MacMahon, 1958). Similar increases in incidence have been reported by several cancer registries for the age range 15-30 (Muir & Nectoux, 1978; Schottenfeld et al., 1980; Clemmesen, 1969; Petersen & Lee, 1972). Current estimates of incidence in British Columbia indicate that approximately 1 in 400 males will develop testicular cancer (Cancer Registry, 1975). The majority of studies of the epidemiology of testicular tumours have used routinely collected data to analyse the effects of factors such as social class, marital status, geography, racial group and religious preference. Case-control studies have analysed factors such as cryptorchidism and other prenatal conditions. Where it was examined, these studies have shown that, while differences exist in the age-specific incidence, treatment and prognosis of seminoma compared to other types of testicular cancer, the relationship to known risk factors is similar (Morrison, 1976b; Graham et al., 1977). The present report examines a number of characteristics of childhood and adolescence in a case-control study of all patients treated for seminoma of the testis at a regional treatment centre in the period 1970-77.

  16. Identifying gaps in breast cancer research: Addressing disparities and the roles of the physical and social environment

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    as part of anti- cancer treatment. Eur J Cancer. 2005, 41(status, and breast cancer treatment and survival. J Natlin the receipt of cancer treatment. J Natl Cancer Inst.

  17. The role of uPAR signaling in lung cancer Background and significance

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    The role of uPAR signaling in lung cancer Background and significance Lung cancer is the leading of lung cancer ­ non-small-cell-lung cancer (about 85% of all lung cancer cases) and small- cell-lung cancer (about 15%) (Herbst et al., 2008). Small cell lung carcinoma (SCLC) is rapidly growing and often

  18. Cold atmospheric plasma in cancer therapy

    SciTech Connect (OSTI)

    Keidar, Michael; Shashurin, Alex; Volotskova, Olga [Mechanical and Aerospace Engineering, George Washington University, Washington DC 20052 (United States)] [Mechanical and Aerospace Engineering, George Washington University, Washington DC 20052 (United States); Ann Stepp, Mary [Medical School, George Washington University, Washington DC 20052 (United States)] [Medical School, George Washington University, Washington DC 20052 (United States); Srinivasan, Priya; Sandler, Anthony [Childrens National Medical Center, Washington DC 20010 (United States)] [Childrens National Medical Center, Washington DC 20010 (United States); Trink, Barry [Head and Neck Cancer Research Division, Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205 (United States)] [Head and Neck Cancer Research Division, Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205 (United States)

    2013-05-15T23:59:59.000Z

    Recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in understanding of cold plasma physics as well as application of cold atmospheric plasma (CAP) in cancer therapy. Varieties of novel plasma diagnostic techniques were developed recently in a quest to understand physics of CAP. It was established that the streamer head charge is about 10{sup 8} electrons, the electrical field in the head vicinity is about 10{sup 7} V/m, and the electron density of the streamer column is about 10{sup 19} m{sup ?3}. Both in-vitro and in-vivo studies of CAP action on cancer were performed. It was shown that the cold plasma application selectively eradicates cancer cells in-vitro without damaging normal cells and significantly reduces tumor size in-vivo. Studies indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. It is also shown that the cancer cells are more susceptible to the effects of CAP because a greater percentage of cells are in the S phase of the cell cycle.

  19. Comprehensive genomic characterization of squamous cell lung cancers

    E-Print Network [OSTI]

    Lander, Eric S.

    Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no ...

  20. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  1. Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

    E-Print Network [OSTI]

    Ooi, Chia Huey

    Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships ...

  2. Function of the anterior gradient protein family in cancer 

    E-Print Network [OSTI]

    Fourtouna, Argyro

    2009-01-01T23:59:59.000Z

    Proteomic technologies verified Anterior Gradient 2, AGR-2, as a protein over-expressed in human cancers, including breast, prostate and oesophagus cancers, with the ability to inhibit the tumour suppressor protein p53. AGR-2 gene is a hormone...

  3. Carbohydrate Intake and Outcomes among Postmenopausal Breast Cancer Survivors /

    E-Print Network [OSTI]

    Emond, Jennifer Ann

    2013-01-01T23:59:59.000Z

    departments, 1992 to 2001. Ann Emerg Med. 2005;46(1):77-81.term breast cancer survivors. Ann Behav Med. 3. Wu AH, Gomezpositive breast cancer cells. Ann Oncol. 2011;22( 1):68-73.

  4. In vitro study of cancer cell extravasation in microfluidic platform

    E-Print Network [OSTI]

    Jeon, Jessie Sungyun

    2014-01-01T23:59:59.000Z

    Cancer metastases arise from the cancer cells that disseminate from the primary tumor, intravasate into the vascular system and eventually transmigrate across the endothelium into to a secondary site through a process of ...

  5. Statistical analysis of Single Nucleotide Polymorphism microarrays in cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Statistical analysis of Single Nucleotide Polymorphism microarrays in cancer studies Pierre Neuvial Nucleotide Polymorphism (SNP) arrays. We define the copy number states formally, and show how Nucleotide Polymorphism microarrays in cancer studies

  6. Diabetes and breast cancer : the women's healthy eating & living study

    E-Print Network [OSTI]

    Erickson, Kirsten Diann

    2011-01-01T23:59:59.000Z

    and their effects on diabetes risk, randomized controlledQiao Q, Zethelius B, et al: Diabetes, prediabetes and cancerS, Lopez A, et al: Diabetes, obesity and survival in a large

  7. Spiritual Coping and Adjustment in Siblings of Children with Cancer 

    E-Print Network [OSTI]

    Kaal, Julia

    2011-11-23T23:59:59.000Z

    Approximately 12 000 US children are diagnosed with some form of cancer every year (Ries et al., 2006)....

  8. WON EXPOSURE AND LUNG CANCER RISK

    E-Print Network [OSTI]

    unknown authors

    As information on indoor air quality accumulated * it became apparent that radon and its progeny are invariably present in indoor environments and that concentrations may reach unacceptably high levels. The lung cancer excess anong miners exposed to radon progeny raised concern that exposure to radon progeny might also cause lung cancer in the general population. This presentation first provides an ovemiew of radon daughter carcinogenesis, and then reviews the recent BEIR IV report. The report described a statistical model * based on analysis of data from four studies of miners, for estimating the lung cancer risk associated with exposure to radon progeny. Tbe analyses showed that the risk of radon exposure declines with time since exposure and with increasing age. The BEIR IV committee concluded that radon progeny and cigarette smoking interact in a multiplicative fashion and that exposure-dose relationships are similar for exposure in homes and in mines.

  9. Targeted therapies hold out the promise of a new era in cancer treatment, but will we fear cancer any the less? The making of a modern disease.

    E-Print Network [OSTI]

    Shapin, Steven

    Targeted therapies hold out the promise of a new era in cancer treatment, but will we fear cancer-marrow sample taken, but she knows about leukemia. It's cancer of the blood. She's terrified, and she may not just a cancer ward but a cancer world. The ward is what the sociologist Erving Goffman once called

  10. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

    E-Print Network [OSTI]

    Ren, Yin

    A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches. Efforts such as The Cancer Genome Atlas Project will identify genes ...

  11. Breast Cancer Cells Induce Cancer-Associated Fibroblasts to Secrete Hepatocyte Growth Factor to Enhance Breast Tumorigenesis

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    fetal bovine serum and 1610 5 MDA-MB-468 cells were seededwith human breast cancer MDA-MB-468 cells in a transwellNAFs with breast cancer MDA-MB-468 cells in a transwell

  12. High Prevalence of Lung Cancer in a Surgical Cohort of Lung Cancer Patients A Decade After Smoking Cessation

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    AJ, Samet M: Epidemiology of Lung Cancer. Chest 2003, 123:The accumulated evidence on lung cancer and environmentalMR, Fueger JJ, et al: “Lung carcinoma in former smokers”.

  13. Discovering Novel Cancer Therapies: A Computational Modeling and Search Approach

    E-Print Network [OSTI]

    Flann, Nicholas

    of new blood vessels (angiogenesis) is an important approach in cancer treatment. However, the complexity-based approach for the discovery of novel potential cancer treatments using a high fidelity simulation in cancer treatment [2]. This paper introduces a computational approach to search for novel intervention

  14. COMPUTER SUPPORT FOR PROTOCOL-BASED TREATMENT OF CANCER1

    E-Print Network [OSTI]

    Sergot, Marek

    COMPUTER SUPPORT FOR PROTOCOL-BASED TREATMENT OF CANCER1 PETER HAMMOND2 AND MAREK SERGOT3 July 1994 Cancer treatment is often carried out within protocol-based clinical trials. An oncology clinic may take of many protocols, the life-threatening nature of cancer and the toxicity of treatment side

  15. An Optimal Control Approach to Cancer Treatment under Immunological Activity

    E-Print Network [OSTI]

    Ledzewicz, Urszula

    An Optimal Control Approach to Cancer Treatment under Immunological Activity Urszula Ledzewicz Mathematical models for cancer treatment that include immunological activity are con- sidered as an optimal. For various growth models on the cancer cells the existence and optimality of singular controls

  16. Optimisation of cancer drug treatments using cell population dynamics

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Optimisation of cancer drug treatments using cell population dynamics Fr´ed´erique Billy1 , Jean. The constraints at stake, met everyday in the clinic of cancers, are related mainly to resistance to treatment models used in cancer treatment in the last decades, together with the biological phenomena that can

  17. Controlling the Bone Marrow Dynamics in Cancer Chemotherapy

    E-Print Network [OSTI]

    Ledzewicz, Urszula

    Professor Award 1 #12;find optimal strategies for chemotherapy treatments of the cancer, where Controlling the Bone Marrow Dynamics in Cancer Chemotherapy Urszula Ledzewicz1 and Heinz Sch In the paper a mathematical model for the growth of the bone marrow under cell-cycle specific cancer

  18. QUANTITATIVE SONOGRAPHIC PROSTATE CANCER CHARACTERIZTION A Thesis Presented

    E-Print Network [OSTI]

    Huston, Dryver R.

    QUANTITATIVE SONOGRAPHIC PROSTATE CANCER CHARACTERIZTION A Thesis Presented by Zhi He are at risk for developing prostate cancer, and as a man ages, his risk of developing prostate cancer acquiring the ultrasound data, the specimen is sectioned for histological analysis at 2 mm intervals

  19. Cancer Phylogenetics from Single-Cell Assays Gregory Pennington

    E-Print Network [OSTI]

    Cancer Phylogenetics from Single-Cell Assays Gregory Pennington Stanley Shackney Russell Schwartz the Carnegie Mellon University Berkman Faculty Development Fund. #12;Keywords: computational biology, cancer, FISH, phylogeny #12;Abstract In the field of cancer biology, there is currently great interest

  20. Genetic Susceptibility and Survival: Application to Breast Cancer

    E-Print Network [OSTI]

    West, Mike

    Genetic Susceptibility and Survival: Application to Breast Cancer Edwin S. IVERSEN, JR., Giovanni are known to confer an elevated risk of both breast and ovarian cancers. The effect of carrying such a mutation on survival after developing breast or ovarian cancer is less well understood. We investigate

  1. Putting cancer in focusPathologists key to picking the

    E-Print Network [OSTI]

    Eichman, Brandt F.

    Putting cancer in focusPathologists key to picking the right path to a cure momentum IN THIS ISSUE without cancer. #12;EDITOR Heather Newman DESIGN Diana Duren DIRECTOR OF PUBLICATIONS Wayne Wood ASSOCIATE / Photo Researchers, Inc. EDITORIAL OFFICE Vanderbilt-Ingram Cancer Center 691 Preston Building Nashville

  2. Exploring the Relationship between Neutral and Selective Mutations in Cancer

    E-Print Network [OSTI]

    Forrest, Stephanie

    Exploring the Relationship between Neutral and Selective Mutations in Cancer C. C. Maley 1;2 and S. Forrest 2;3 (cmaley@alum.mit.edu and forrest@cs.unm.edu) 1 Fred Hutchinson Cancer Research Center 1100 of normal cells into cancerous cells is an evolu- tionary process. Populations of precancerous cells

  3. AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER Marius George LINGURARU, Oxford OX2 7BZ, United Kingdom mglin@robots.ox.ac.uk Abstract: The prevalence of breast cancer must provide effective clinical methods to detect cancer and improve life expectancy. Considerable

  4. Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance

    E-Print Network [OSTI]

    Hanson, Floyd B.

    Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance J. J. Westman-7045 USA Abstract A compartment model for the evolution of cancer subject to multiple chemotherapeutic agents is presented. The formulation accounts for the heterogeneous nature of cancer and drug resistance

  5. Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy

    E-Print Network [OSTI]

    Smith, Elizabeth Brooks

    2009-05-15T23:59:59.000Z

    Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

  6. [CANCER RESEARCH 61, 59745978, August 15, 2001] Advances in Brief

    E-Print Network [OSTI]

    Jin, Jiashun

    [CANCER RESEARCH 61, 5974­5978, August 15, 2001] Advances in Brief Analysis of Gene Expression Identifies Candidate Markers and Pharmacological Targets in Prostate Cancer John B. Welsh, Lisa M. Sapinoso., H. F. F.] Abstract Detection, treatment, and prediction of outcome for men with prostate cancer

  7. An analysis and hypothesis generation platform for heterogeneous cancer

    E-Print Network [OSTI]

    Reed, Chris

    An analysis and hypothesis generation platform for heterogeneous cancer databases. Philip Roy QUINLAN a,1, Alastair THOMPSON a and Chris REED b a Dundee Cancer Centre, University of Dundee, Ninewells Hospital, Dundee b School of Computing, University of Dundee, Dundee Abstract. The field of cancer research

  8. Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a)

    E-Print Network [OSTI]

    Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a) , Davina Porock(b) , Nick of the study: was to evaluate the attitudinal barriers to cancer-pain management among cnacer patients five factors . These factors contribute to ineffective cancer pain management among them and include

  9. Microfabricated Optical Sensor Probe for the Detection of Esophageal Cancer

    E-Print Network [OSTI]

    Chinna Balareddy, Karthik Reddy

    2012-10-19T23:59:59.000Z

    Cancer is a class of diseases in which a group of cells grow uncontrollably, destroy surrounding tissue and eventually spread to other parts of the body, often leading to death. According to the American Cancer Society cancer causes accounts for 13...

  10. Glucose conjugation for the specific targeting and treatment of cancer

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    Glucose conjugation for the specific targeting and treatment of cancer Emilia C. Calvaresia and Paul J. Hergenrother*ab Cancers of diverse origins exhibit marked glucose avidity and high rates has led to an interest in targeting it for cancer therapy. One promising strategy for such targeting

  11. DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER

    E-Print Network [OSTI]

    Raphael, Ben J.

    DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER FABIO VANDIN, PATRICK CLAY,pclay,eli,braphael}@cs.brown.edu A major goal of cancer sequencing projects is to identify genetic alterations that determine clinical phenotypes, such as survival time or drug response. Somatic mutations in cancer are typically very diverse

  12. Friday, April 29, 2011 UNM Research Looks at Cancer

    E-Print Network [OSTI]

    Brinker, C. Jeffrey

    Friday, April 29, 2011 UNM Research Looks at Cancer By Olivier Uyttebrouck Copyright © 2011 Albuquerque Journal Journal Staff Writer Chemotherapy can save the lives of cancer patients, but side effects are developing a technique they say can deliver minute amounts of cancer-fighting drugs directly into a diseased

  13. RESEARCH ARTICLE Open Access Survival advantages conferred to colon cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    RESEARCH ARTICLE Open Access Survival advantages conferred to colon cancer cells by E Klinck5 , François A Auger4 and Jacques Huot1* Abstract Background: Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells

  14. Animal Cancer Care and Research Program Summer 2011

    E-Print Network [OSTI]

    Minnesota, University of

    Synergy Animal Cancer Care and Research Program Summer 2011 Michael G. Conzemius, D.V.M., Ph Cancer Care and Research Program 2 · Synergy Summer 2011 COTC016: A pilot study to assess feasibility Clinical Sciences, College of Veterinary Medicine and Masonic Cancer Center T he University of Minnesota

  15. ORAL CANCER IN NEVADA: A PUBLIC HEALTH PERSPECTIVE

    E-Print Network [OSTI]

    Ahmad, Sajjad

    ORAL CANCER IN NEVADA: A PUBLIC HEALTH PERSPECTIVE by Karl Kingsley, PhD Doctor of Philosophy the thesis prepared under our supervision by Karl Kingsley, Ph.D. entitled Oral Cancer in Nevada: A Public May 2010 #12;iii ABSTRACT Oral Cancer in Nevada: A Public Health Perspective by Karl Kingsley, Ph

  16. Cancer Cell Dissecting the Unique Role of the Retinoblastoma

    E-Print Network [OSTI]

    Cancer Cell Article Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has for cancer development; hence, the roles and regulation of RB have been intensively studied (reviewed

  17. BIOL10500 The Biology of Cancer Spring 2012

    E-Print Network [OSTI]

    every cell type in the body. This course will investigate how genetic and environmental factors lead to transformation of cells, how cancer cells function, the cellular systems designed to protect normal cells from becoming cancerous, and how the immune system protects against cancer. The course will examine the growth

  18. Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn

    E-Print Network [OSTI]

    Gilsinn, David E.

    Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn Bruce R. Borchardt Amelia Tebbe§ July 15, 2009 Abstract Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. Computed to- mography (CT) shows promise in detecting lung cancers at earlier, more operable

  19. A Systems Approach to Breast Cancer Carcinogenesis to Therapy

    E-Print Network [OSTI]

    A Systems Approach to Breast Cancer ­ Carcinogenesis to Therapy Speaker: Dr. Joe Gray Director, Center for Spatial Systems Biomedicine Oregon Health & Science University Date: Monday, April 18, 2011 that influence cancer behavior, (b) systems biology approaches to elucidate mechanisms by which cancer

  20. Effect of treatment and diet on body weight after breast cancer diagnosis : the women's healthy eating and living (WHEL) study perspective

    E-Print Network [OSTI]

    Saquib, Abu Taiyab M. N.

    2007-01-01T23:59:59.000Z

    behavioral, cancer, and treatment related variables, thoughtbehavioral, cancer, and treatment related characteristicsweight after breast cancer treatments: evidence from the

  1. Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer ?

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    of this network trying to improve the treatment of pancreatic cancer patients. Recent findings: Tarceva has the mechanisms of cell transformation and also to find appropriate targeted anti- cancer treatments. Among human in the therapeutic armamentarium against cancer raised some hopes in the treatment of patients with advanced

  2. 17/03/2006 Accepted in European Journal of Cancer Prevention Time Trends and Geographic Variations for Thyroid Cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    17/03/2006 Accepted in European Journal of Cancer Prevention 1 Time Trends and Geographic Variations for Thyroid Cancer in New Caledonia, a Very High Incidence Area (1985-1999) Thérèse Truong1 mail: guenel@vjf.inserm.fr Running head: Incidence of thyroid cancer in New Caledonia #12

  3. Identifying Men Diagnosed With Clinically Localized Prostate Cancer Who are at High Risk for Death From Prostate Cancer

    E-Print Network [OSTI]

    Chen, Ming-Hui

    Identifying Men Diagnosed With Clinically Localized Prostate Cancer Who are at High Risk for Death From Prostate Cancer Anthony V. D'Amico,* Ming Hui-Chen, Andrew A. Renshaw, Brenda Sussman, Kimberly A), Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, Department

  4. Lung Cancer . Author manuscript p16INK4A inactivation mechanisms in non-small-cell lung cancer patients

    E-Print Network [OSTI]

    Boyer, Edmond

    Lung Cancer . Author manuscript Page /1 10 p16INK4A inactivation mechanisms in non-small-cell lung occupational risk factor and that asbestos acts synergistically with tobacco smoking to induce lung cancer. Although some somatic gene alterations in lung cancer have been linked to tobacco smoke, few data

  5. Strong Memorial Hospital Cancer Committee Report 2 2011 Strong Memorial Hospital Cancer Registry Report

    E-Print Network [OSTI]

    Goldman, Steven A.

    's two largest cancer research facilities could result in a scientific powerhouse, enhancing faculty patients.This accounts for an accrual rate of 16.9 percent using the 2010 registry data for total number

  6. Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

    SciTech Connect (OSTI)

    Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

    2012-07-01T23:59:59.000Z

    Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

  7. Small cell lung cancer and cancer stem cell-like cells 

    E-Print Network [OSTI]

    Sarvi, Sana

    2014-07-05T23:59:59.000Z

    Small cell lung cancer (SCLC) is a highly aggressive malignancy with extreme mortality and morbidity. Although initially chemo- and radio-sensitive, almost inevitable recurrence and resistance occurs. SCLC patients often ...

  8. Spontaneous Remission of Cancer: Theories from Healers, Physicians, and Cancer Survivors

    E-Print Network [OSTI]

    Turner, Kelly Ann

    2010-01-01T23:59:59.000Z

    cancer during chemotherapy. Ann Oncol, 20(8), 1445-1446.in people with HIV/AIDS. Ann Behav Med, 24(1), 34- Ishak,biological pathways involved. Ann Oncol, 8(10), 1031-1039.

  9. Mutational heterogeneity in cancer and the search for new cancer genes

    E-Print Network [OSTI]

    Helman, Elena

    Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched ...

  10. Activin inhibits telomerase activity in cancer

    SciTech Connect (OSTI)

    Katik, Indzi; Mackenzie-Kludas, Charley; Nicholls, Craig [Department of Immunology, Monash University, Melbourne (Australia)] [Department of Immunology, Monash University, Melbourne (Australia); Jiang, Fang-Xu [Centre for Diabetes Research, Western Australian Institute for Medical Research and The University of Western Australia, Perth (Australia)] [Centre for Diabetes Research, Western Australian Institute for Medical Research and The University of Western Australia, Perth (Australia); Zhou, Shufeng [School of Health Sciences, RMIT University, Melbourne (Australia)] [School of Health Sciences, RMIT University, Melbourne (Australia); Li, He [Department of Immunology, Monash University, Melbourne (Australia)] [Department of Immunology, Monash University, Melbourne (Australia); Liu, Jun-Ping, E-mail: jun-ping.liu@med.monash.edu.au [Department of Immunology, Monash University, Melbourne (Australia)] [Department of Immunology, Monash University, Melbourne (Australia)

    2009-11-27T23:59:59.000Z

    Activin is a pleiotropic cytokine with broad tissue distributions. Recent studies demonstrate that activin-A inhibits cancer cell proliferation with unknown mechanisms. In this report, we demonstrate that recombinant activin-A induces telomerase inhibition in cancer cells. In breast and cervical cancer cells, activin-A resulted in telomerase activity in a concentration-dependent manner. Significant inhibition was observed at 10 ng/ml of activin-A, with a near complete inhibition at 80 ng/ml. Consistently, activin-A induced repression of the telomerase reverse transcriptase (hTERT) gene, with the hTERT gene to be suppressed by 60-80% within 24 h. In addition, activin-A induced a concomitant increase in Smad3 signaling and decrease of the hTERT gene promoter activity in a concentration-dependent fashion. These data suggest that activin-A triggered telomerase inhibition by down-regulating hTERT gene expression is involved in activin-A-induced inhibition of cancer cell proliferation.

  11. Isotope Cancer Treatment Research at LANL

    ScienceCinema (OSTI)

    Weidner, John; Nortier, Meiring

    2014-06-02T23:59:59.000Z

    Los Alamos National Laboratory has produced medical isotopes for diagnostic and imaging purposes for more than 30 years. Now LANL researchers have branched out into isotope cancer treatment studies. New results show that an accelerator-based approach can produce clinical trial quantities of actinium-225, an isotope that has promise as a way to kill tumors without damaging surrounding healthy cells.

  12. Small RNA combination therapy for lung cancer

    E-Print Network [OSTI]

    Tammela, Tuomas

    MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering ...

  13. Hypoxia activated cell signaling receptors in cancer

    E-Print Network [OSTI]

    Lester, Robin D.

    2008-01-01T23:59:59.000Z

    Cancer Res. 61:7992-8. Graeber, T.G. , C. Osmanian, T.solid tumours. 379:88-91. Graeber, T.G. , J.F. Peterson, M.by accumulation of p53 (Graeber et al. , 1994), has been the

  14. Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth

    E-Print Network [OSTI]

    of the disease. Thus, drugs that selectively target cancer stem cells offer great promise for cancer treatment and chemotherapeutic drugs to improve treatment of patients with breast (and possibly other) cancers. [Cancer Res 2009;69(19):7507­11] Introduction Chemotherapeutic treatments for cancer can effectively reduce tumor mass, but the disease often

  15. Get Online Support, Feel Better--Sentiment Analysis and Dynamics in an Online Cancer

    E-Print Network [OSTI]

    ] from cancer and cancer treatments. Each year, many people turn to the Internet to satisfy their health offers a way to share experiences about their cancer and cancer treatment, seek solutions to daily livingGet Online Support, Feel Better--Sentiment Analysis and Dynamics in an Online Cancer Survivor

  16. Get Online Support, Feel Better--Sentiment Analysis and Dynamics in an Online Cancer

    E-Print Network [OSTI]

    Giles, C. Lee

    ] from cancer and cancer treatments. Each year, many people turn to the Internet to satisfy their health to share experiences about their cancer and cancer treatment, seek solutions to daily living issuesGet Online Support, Feel Better--Sentiment Analysis and Dynamics in an Online Cancer Survivor

  17. Changing the Face of Cancer through investments in research, education, outreach and care

    E-Print Network [OSTI]

    Chapman, Michael S.

    this progress. Gifts: · Advance the studies of new cancer treatments · Recruit and keep talented researchersChanging the Face of Cancer through investments in research, education, outreach and care Giving Guide #12;OHSU Knight Cancer Institute We Will End Cancer As We Know It The OHSU Knight Cancer Institute

  18. “It’s Not If I Get Cancer, It’s When I Get Cancer”: Exploring Previvors’ Management of Uncertainty for Hereditary Cancer in Clinical Encounters

    E-Print Network [OSTI]

    Dean, Marleah Lynn

    2014-07-10T23:59:59.000Z

    decisions affect their subsequent sense of uncertainty. A previvor is an individual who is highly predisposed to breast and ovarian cancer due to a genetic mutation called BRCA1/2. Previvors have a 44 to 87 percent risk of developing cancer during...

  19. Compositions and methods for cancer treatment using targeted carbon nanotubes

    DOE Patents [OSTI]

    Harrison, Jr., Roger G; Resasco, Daniel E; Neves, Luis Filipe Ferreira

    2013-08-27T23:59:59.000Z

    The present invention is a method for detecting and destroying cancer tumors. The method is based on the concept of associating a linking protein or linking peptide such as, but not limited to, annexin V or other annexins to carbon nanotubes such as single-walled carbon nanotubes (SWNTs) to form a protein-CNT complex. Said linking protein or peptide can selectively bind to cancerous cells, especially tumor vasculature endothelial cells, rather than to healthy ones by binding to cancer-specific external receptors such as anionic phospholipids including phosphatidylserine expressed on the outer surfaces of cancer cells only. Irradiation of bound CNTs with one or more specific electromagnetic wavelengths is then used to detect and destroy those cells to which the CNTs are bound via the linking protein or peptide thereby destroying the tumor or cancer cells and preferably an immunostimulant is provided to the patient to enhance the immune response against antigens released from the tumor or cancer cells.

  20. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-04T23:59:59.000Z

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks — particularly with regard to breast cancer.

  1. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Gray, Joe

    2011-04-28T23:59:59.000Z

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  2. Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    disease in non-small cell lung cancer. Semin ThoracW, Khuri FR: The care of the lung cancer patient in the 21stJablons DM: Wnt signaling in lung cancer. Cancer Lett 2005,

  3. For Immediate Release --Wednesday, March 20, 2013 Treating male and female cancer patients with radiation

    E-Print Network [OSTI]

    Seldin, Jonathan P.

    ? · gender differences in cancer treatment rarely explored · consequences of radiation with radiation treatment of cancer cells and the difference between female and male or female-specific treatments that improve the quality of life for all cancer

  4. Functional census of mutation sequence spaces: The example of p53 cancer rescue mutants

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    aid the search for cancer treatments from p53 mutant rescue.26], [27], [28]. Novel Cancer Treatments and p53 FunctionalCentral to the goal of cancer treatment by p53 functional

  5. Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy.

    E-Print Network [OSTI]

    Cerussi, Albert E; Tanamai, Vaya W; Hsiang, David; Butler, John; Mehta, Rita S; Tromberg, Bruce J

    2011-01-01T23:59:59.000Z

    therapeutic endpoints for cancer treatments are 5–10 yearto endocrine treatment in breast cancer. J. Clin. Oncol. 24,E. 2006 Neoadjuvant treatment for early-stage breast cancer:

  6. Development of alternating amphiphilic copolymers for targeted delivery applications in cancer

    E-Print Network [OSTI]

    Brower, Kevin P. (Kevin Peter)

    2011-01-01T23:59:59.000Z

    According to the American Cancer Society, approximately 1,479,000 new cases of cancer were expected to be diagnosed, while 562,340 Americans were expected to die from cancer in 2009 alone. Even though advances in early ...

  7. Potential for Cardiovascular Exercise Dosing to Improve Cardiorespiratory Fitness in Breast Cancer Survivors

    E-Print Network [OSTI]

    Burnett, Dave

    2013-05-31T23:59:59.000Z

    With an increase in early detection and curative treatment for breast cancer, there is a growing number of breast cancer survivors. Cancer survivors are at greater risk than their age matched peers for long-term health ...

  8. Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery

    E-Print Network [OSTI]

    Snow, Merideth

    2010-07-14T23:59:59.000Z

    Breast cancer is the second leading cause of cancer deaths in women with approximately 40,000 patient deaths each year. Theranostics is an emerging area of cancer research in which chemically synthesized molecules are used to simultaneously deliver...

  9. McGill Cancer NutritionRehabilitation Program Annual Report 2010 AAPPPPEENNDDIIXX II

    E-Print Network [OSTI]

    Barthelat, Francois

    McGill Cancer NutritionRehabilitation Program Annual Report 2010 Appendix-1 AAPPPPEENNDDIIXX II CCLLIINNIICCAALL AACCTTIIVVIITTYY MCGILL CANCER NUTRITIONREHABILITATION PROGRAM changes in team structure in 2010. ** No Social Worker on staff in 2010. #12;McGill Cancer Nutrition

  10. McGill Cancer NutritionRehabilitation Program Annual Report 2009 AAPPPPEENNDDIIXX II

    E-Print Network [OSTI]

    Barthelat, Francois

    McGill Cancer NutritionRehabilitation Program Annual Report 2009 AAPPPPEENNDDIIXX II CCLLIINNIICCAALL AACCTTIIVVIITTYY McGill Cancer NutritionRehabilitation Program Statistics for January;McGill Cancer NutritionRehabilitation Program Annual Report 2009 AAPPPPEENNDDIIXX IIII

  11. Cancer survivors and survivorship care: Provider expectations, post-treatment health services, and patient reported outcomes

    E-Print Network [OSTI]

    Hahn, Erin Elizabeth

    2013-01-01T23:59:59.000Z

    2011) Long Term Effects and Cancer Survivorship in the OlderGanz (Eds. ), Management of Cancer for the Older Patient (the Quality of Care for Cancer Survivors. Psycho-Oncology (

  12. advanced rectal cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    advanced rectal cancer (LARC) and the impact of partial volume effects correction (PVC PVC. Their predictive value was investigated using Mann-Whitney-U tests and ROC...

  13. ascending colon cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: , and Genetic Discoveries in Pancreatic, Liver, and Biliary Cancers Program specialists are pioneering new and individualized care for patients with...

  14. azoxymethane colon cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: , and Genetic Discoveries in Pancreatic, Liver, and Biliary Cancers Program specialists are pioneering new and individualized care for patients with...

  15. adequate cervical cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and fee-for-service-based Family Health Groups receive bonuses for delivering preventive care, including cervical cancer screening, while those practicing (more)...

  16. advanced cervical cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and fee-for-service-based Family Health Groups receive bonuses for delivering preventive care, including cervical cancer screening, while those practicing (more)...

  17. advanced cervical cancers: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and fee-for-service-based Family Health Groups receive bonuses for delivering preventive care, including cervical cancer screening, while those practicing (more)...

  18. african cervical cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and fee-for-service-based Family Health Groups receive bonuses for delivering preventive care, including cervical cancer screening, while those practicing (more)...

  19. Yeast-based vaccine approaches to cancer immunotherapy

    E-Print Network [OSTI]

    Howland, Shanshan W

    2008-01-01T23:59:59.000Z

    Saccharomyces cerevisiae stimulates dendritic cells and represents a promising candidate for cancer immunotherapy development. Effective cross-presentation of antigen delivered to dendritic cells is necessary for successful ...

  20. School Response to Families with Children with Cancer

    E-Print Network [OSTI]

    Nielsen, Shelley Lynn

    2010-01-01T23:59:59.000Z

    Sports x Relationship with School None Good Very Good x x xissues in childhood cancer. School Psychology Review, 28(2),quality of life, and school experiences. Exceptional

  1. Molecular cytogenetic characterization of a human thyroid cancer cell line

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    gland during the Chernobyl catastrophe. Environmental Healthradiation as a result of the Chernobyl disaster. Cancer 76,1986 nuclear accident in Chernobyl, Ukraine. In the twelve

  2. Identification of cancer protein biomarkers using proteomic techniques

    DOE Patents [OSTI]

    Mor, Gil G. (Cheshire, CT); Ward, David C. (Las Vegas, NV); Bray-Ward, Patricia (Las Vegas, NV)

    2010-02-23T23:59:59.000Z

    The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.

  3. Jefferson Lab Medical Imager Spots Breast Cancer | Jefferson...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Eric Rosen, Duke University Medical Center Jefferson Lab Medical Imager Spots Breast Cancer March 3, 2005 Newport News, VA - A study published in the February issue of the...

  4. Protocadherin-7 induces bone metastasis of breast cancer

    SciTech Connect (OSTI)

    Li, Ai-Min [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China)] [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China); Tian, Ai-Xian [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Zhang, Rui-Xue [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China)] [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China); Ge, Jie [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Sun, Xuan [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Cao, Xu-Chen, E-mail: caoxuch@126.com [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)

    2013-07-05T23:59:59.000Z

    Highlights: •PCDH7 is overexpression in high bone metastatic MDA-MB-231 cells. •PCDH7 is up-regulation in bone metastatic breast cancer tissues. •Suppression of PCDH7 inhibits cell proliferation, migration, and invasion in vitro. •PCDH7 induces breast cancer bone metastasis in vivo. -- Abstract: Breast cancer had a propensity to metastasize to bone, resulting in serious skeletal complications associated with poor outcome. Previous study showed that Protocadherin-7 (PCDH7) play an important role in brain metastatic breast cancer, however, the role of PCDH7 in bone metastatic breast cancer has never been explored. In the present study, we found that PCDH7 expression was up-regulation in bone metastatic breast cancer tissues by real-time PCR and immunohistochemistry assays. Furthermore, suppression of PCDH7 inhibits breast cancer cell proliferation, migration, and invasion in vitro by MTT, scratch, and transwell assays. Most importantly, overexpression of PCDH7 promotes breast cancer cell proliferation and invasion in vitro, and formation of bone metastasis in vivo. These data provide an important insight into the role of PCDH7 in bone metastasis of breast cancer.

  5. Insight into Alzheimer's, cancer, anemia gleaned from ribosome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insights from ribosome research Insight into Alzheimer's, cancer, anemia gleaned from ribosome research Groundbreaking study of the human ribosome reveals tiny molecular machine is...

  6. Three-Dimensional Thermal Tomography Advances Cancer Treatment...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Three-Dimensional Thermal Tomography Advances Cancer Treatment Technology available for licensing: A 3D technique to detect early skin changes due to radiation treatment in breast...

  7. DOE/EA-0965 ENVIRONMENTAL ASSESSMENT CANCER RESEARCH CENTER

    Broader source: Energy.gov (indexed) [DOE]

    65 ENVIRONMENTAL ASSESSMENT CANCER RESEARCH CENTER INDIANA UNIVERSITY SCHOOL OF MEDICINE PREPARED BY U.S. DEPARTMENT O F ENERGY, CHICAGO FIELD OFFICE PROGRAMS AND FACILITIES...

  8. attenuates bone cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    human bone were studied via the small scale mechanical loading test. Failure analysis was conducted... Jang, Eunhwa 2012-10-19 19 ORIGINAL ARTICLE JBMR Cancer Treatment...

  9. Nanotechnology in Head and Neck Cancer: The Race Is On

    E-Print Network [OSTI]

    El-Sayed, Ivan H.

    2010-01-01T23:59:59.000Z

    10.1007/s11912-010-0087-2 Nanotechnology in Head and Neckthe applications of nanotechnology in head and neck cancer,plasmonic gold nanotechnology. Keywords Nanotechnology .

  10. Published: February 18, 2011 r 2011 American Chemical Society 2470 dx.doi.org/10.1021/jp1122294 |J. Phys. Chem. B 2011, 115, 24702476

    E-Print Network [OSTI]

    States Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute of a fatal neurodegenerative disease, classical late-infantile neuronal ceroid lipofuscinosis.3

  11. SU-E-J-95: Predicting Treatment Outcomes for Prostate Cancer: Irradiation Responses of Prostate Cancer Stem Cells

    SciTech Connect (OSTI)

    Wang, K [University of Miami, Miami, FL (United States)

    2014-06-01T23:59:59.000Z

    Purpose: Most prostate cancers are slow-growing diseases but normally require much higher doses (80Gy) with conventional fractionation radiotherapy, comparing to other more aggressive cancers. This study is to disclose the radiobiological basis of this discrepancy by proposing the concept of prostate cancer stem cells (CSCs) and examining their specific irradiation responses. Methods: There are overwhelming evidences that CSC may keep their stemness, e.g. the competency of cell differentiation, in hypoxic microenvironments and hence become radiation resistive, though the probability is tiny for aggressiveness cancers. Tumor hypoxia used to be considered as an independent reason for poor treatment outcomes, and recent evidences showed that even prostate cancers were also hypoxic though they are very slow-growing. In addition, to achieve comparable outcomes to other much more aggressive cancers, much higher doses (rather than lower doses) are always needed for prostate cancers, regardless of its non-aggressiveness. All these abnormal facts can only be possibly interpreted by the irradiation responses characteristics of prostate CSCs. Results: Both normal cancer cells (NCCs) and CSCs exiting in tumors, in which NCCs are mainly for symptoms whereas killing all CSCs achieves disease-free. Since prostate cancers are slow-growing, the hypoxia in prostate cancers cannot possibly from NCCs, thus it is caused by hypoxic CSCs. However, single hypoxic cell cannot be imaged due to limitation of imaging techniques, unless a large group of hypoxic cells exist together, thus most of CSCs in prostate cancers are virtually hypoxic, i.e. not in working mode because CSCs in proliferating mode have to be normoxic, and this explains why prostate cancers are unaggressive. Conclusion: The fractional dose in conventional radiotherapy (?2Gy) could only kill NCCs and CSCs in proliferating modes, whereas most CSCs survived fractional treatments since they were hypoxic, thus to eliminate all CSCs and achieve disease-free, much more fractionations are needed.

  12. antibody-targeted radiation cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  13. E-Print Network 3.0 - assessment guidelines cancer Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the NYS Cancer Services Program Summary: cancer and should be referred to an appropriate health care provider for a full risk assessment which can... for risk assessment (http:...

  14. age-adjusted cancer mortality: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer Mortality Kenneth G. Brown; Barbara D. Beck; Claudia Hopenhayn-Rich; Mary Lou Biggs; Allan H. Smith Biology and Medicine Websites Summary: Arsenic and Bladder Cancer...

  15. Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence

    E-Print Network [OSTI]

    Duin, Robert P.W.

    2005-01-01T23:59:59.000Z

    Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence bronchoscopy spectroscopy; Lung cancer; Bronchoscopy Summary Detection of malignancies of the bronchial tree in an early

  16. Dana-Farber Cancer Institute About Dana-Farber Cancer Institute

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    to patients from across the country and around the world. #12;About the Jimmy Fund The Jimmy Fund raises vital, the generosity of millions of people has helped the Jimmy Fund save countless lives and reduce the burden of cancer. The Jimmy Fund has: ·raised more than $875 million since 1948, including $67 million in 2012

  17. New Directions and Approached to Cancer Treatment: Dr Mike Partridge

    E-Print Network [OSTI]

    New Directions and Approached to Cancer Treatment: Imaging Dr Mike Partridge STFC Workshop, Birmingham, 28th January 2010 Joint Department of Physics The Institute of Cancer Research / The Royal to treatment to determine anatomical targets and organs-at-risk. · A clear next step is to use biological

  18. An ecological study of lymphatic cancer mortality in Texas

    E-Print Network [OSTI]

    Noel, Lawrence Brooks

    1999-01-01T23:59:59.000Z

    and histiocytic tissue, multiple myeloma and immunoproliferative neoplasms, and leukemia (ICD codes 200-208). An ecological study was conducted of lymphatic cancer deaths from 1986-1994 for the 194 counties in Texas. Death rates of these cancers were correlated...

  19. The use of polarized light for skin cancer detecton

    E-Print Network [OSTI]

    DeLaughter, Aimee Hill

    2002-01-01T23:59:59.000Z

    and subsequent biopsy of suspicious lesions. Many cancerous lesions are missed and many benign lesions are biopsied using these techniques. This process is painful and expensive. The proposed research is driven by the need for a non-invasive skin cancer...

  20. The Economic Impact of Cancer in West Virginia

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    The Economic Impact of Cancer in West Virginia January 2013 A report prepared for the American Virginia University #12;The Economic Impact of Cancer in West Virginia A Report Prepared for the American West Virginia University 150 Clay St. Morgantown, WV 26501 (304) 293-7831 bebureau@mail.wvu.edu Tami

  1. Page 3 New Approaches in Clinical Trials for Gynecologic Cancers

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    Oncology, and MichaelG.Muto,MD,werethefirstinNewEnglandtoperform robot-assisted radical hysterectomy cancers are offering new treatment options for patients. Page 4 Patient Outcome Studies Support Robotic Approaches for Gynecologic Cancers Comparing outcomes of patients undergoing robotic versus traditional open

  2. Human brain cancer studied by resonance Raman spectroscopy

    E-Print Network [OSTI]

    Sun, Yi

    Human brain cancer studied by resonance Raman spectroscopy Yan Zhou Cheng-Hui Liu Yi Sun Yang Pu://biomedicaloptics.spiedigitallibrary.org/ on 11/16/2012 Terms of Use: http://spiedl.org/terms #12;Human brain cancer studied by resonance Raman of human brain tissues are examined using a confocal micro-Raman system with 532-nm excitation in vitro

  3. SysBioMed Canary Islands Cancer Research

    E-Print Network [OSTI]

    Timmer, Jens

    SysBioMed Canary Islands Cancer Research Institute Winter School on Systems Biology for Medical Applications 27th February ­ 2nd March 2007 Puerto de la Cruz, Tenerife (Canary Islands) Supported by the European Commission (FP6 projects COSBICS and SysBioMed) and the Canary Islands Institute for Cancer

  4. Quantum Dot-Aptamer Conjugates for Synchronous Cancer Imaging, Therapy,

    E-Print Network [OSTI]

    Zhang, Liangfang

    a novel quantum dot (QD)-aptamer(Apt)-doxorubicin (Dox) conjugate [QD-Apt(Dox)] as a targeted cancer of prostate cancer cells that express the PSMA protein. The intercalation of Dox, a widely used antineoplastic in a targeted QD-Apt(Dox) conjugate with reversible self- quenching properties based on a Bi-FRET mechanism

  5. Method for restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

    2000-01-01T23:59:59.000Z

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

  6. New synthetic derivatives of triterpenoids in the treatment of cancer

    E-Print Network [OSTI]

    Papineni, Sabitha

    2009-05-15T23:59:59.000Z

    of these compounds as selective peroxisome proliferator-activated receptor ? (PPAR?) agonists and as cytotoxic anticancer agents has been investigated in colon, prostate and pancreatic cancer cells. In colon cancer cells ?-CDODA-Me arrested the growth at G2/M...

  7. Method for detecting the presence of prostate cancer

    DOE Patents [OSTI]

    Karin, Michael; Luo, Jun-Li; Tan, Wei

    2010-04-13T23:59:59.000Z

    The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.

  8. Berkeley Lab Scientist Co-Leads Breast Cancer Dream Team

    ScienceCinema (OSTI)

    Gray, Joe

    2013-05-29T23:59:59.000Z

    An $16.5 million, three-year grant to develop new and more effective therapies to fight breast cancer was awarded today to a multi-institutional Dream Team of scientists and clinicians that is co-led by Joe Gray, a renowned cancer researcher with the U.S. Department of Energys Lawrence Berkeley National Laboratory. http://newscenter.lbl.gov/

  9. Transcriptional Targeting for Ovarian Cancer Gene Therapy E. Casado,*,

    E-Print Network [OSTI]

    Hemminki, Akseli

    ; gene therapy. INTRODUCTION Ovarian cancer afflicts more than 25,000 women annually in the United States Paz, Madrid, Spain Received November 10, 2000 Ovarian carcinoma is a leading cause of cancer death in women. Though advances in conventional therapies have been achieved, long-term survival rates for most

  10. Gene expression profiling identifies clinically relevant subtypes of prostate cancer

    E-Print Network [OSTI]

    Botstein, David

    and are highest in Western countries (2). In the United States, it is the most frequently diagnosed and the second leading cause of cancer death in men (3). Despite these high death rates, prostate cancer is oftenDepartment of Urology, Louisiana State University Health Sciences Center, New Orleans, LA 70112; gSection of Urology

  11. New synthetic derivatives of triterpenoids in the treatment of cancer 

    E-Print Network [OSTI]

    Papineni, Sabitha

    2009-05-15T23:59:59.000Z

    of these compounds as selective peroxisome proliferator-activated receptor ? (PPAR?) agonists and as cytotoxic anticancer agents has been investigated in colon, prostate and pancreatic cancer cells. In colon cancer cells ?-CDODA-Me arrested the growth at G2/M...

  12. Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes

    E-Print Network [OSTI]

    Collins, Gary S.

    studied are the ways that major components of the diet such as protein, fat, and lifestyle issues impactDiet, nutrients, phytochemicals, and cancer metastasis suppressor genes Gary G. Meadows # Springer and mortality of cancer patients is metastasis. There exists a relative lack of specific therapeutic approaches

  13. Investigating the initiation and progression of small cell lung cancer

    E-Print Network [OSTI]

    Brauneis, Alison Dooley

    2011-01-01T23:59:59.000Z

    Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. ...

  14. Statistical analysis of end-points in cancer clinical trials

    E-Print Network [OSTI]

    Campbell, Ian

    the treatment. 'Quality of life' cannot be defined precisely, and the term is used to cover three types of approach. Firstly, the control of symptoms due to a cancer can be assessed, for example control of cough and chest pain from a lung cancer can be measured...

  15. advanced stomach cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    advanced stomach cancer First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Stomach cancer...67 Chapter 07...

  16. Recent Progress in Ultra-Wideband Microwave Breast Cancer Detection

    E-Print Network [OSTI]

    Coates, Mark

    were diagnosed in the United States and Canada ­ with as many as 45,000 cases leading to death. For women, breast cancer mortality rates are higher than for any other cancer, with the exception of lung as early as possible. This will not only reduce mortality and incidence rates, but also significantly ease

  17. Lung Cancer and Arsenic Concentrations in Drinking Water in Chile

    E-Print Network [OSTI]

    California at Berkeley, University of

    Lung Cancer and Arsenic Concentrations in Drinking Water in Chile Catterina Ferreccio,1,2 Claudia- trations have since been reduced to 40 g/liter. We investi- gated the relation between lung cancer and arsenic in drinking water in northern Chile in a case-control study involving patients diagnosed with lung

  18. Laser research shows promise for cancer treatment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your Home asLCLSLaboratoryRowlandRevolutionizingLaserLaserCancer

  19. According to the American Cancer Society, one-third of all cancer deaths each year in the United States

    E-Print Network [OSTI]

    Grishok, Alla

    body weight, you must balance the amount of energy you put into your body­ the food you eatAccording to the American Cancer Society, one-third of all cancer deaths each year in the United States are linked to the amount of food you eat, your body weight, and how much exercise you get. Another

  20. Int J Cancer. Author manuscript Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    peptidimer-c, inhibited colony formation in HER2 over-expressing SKBr3 cancer cells. Combined treatment ; Apoptosis ; drug effects ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Synergism ; Female cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel Gril

  1. Milk Fermented by Propionibacterium freudenreichii Induces Apoptosis of HGT-1 Human Gastric Cancer Cells

    E-Print Network [OSTI]

    Brest, Université de

    and/or as a food supplement to potentiate cancer therapeutic treatments. Citation: Cousin FJ, JouanMilk Fermented by Propionibacterium freudenreichii Induces Apoptosis of HGT-1 Human Gastric Cancer cancer is one of the most common cancers in the world. The ``economically developed countries'' life

  2. Facts to Help Patients Make an Informed Decision TARGETING CANCER CARE

    E-Print Network [OSTI]

    Kaski, Samuel

    cancer through studies called clinical trials. Today's lung cancer radiation therapy treatments provide treatments or medications to help. Everyone responds differently to the stress of cancerFacts to Help Patients Make an Informed Decision TARGETING CANCER CARE © ASTRO 2012 Printed

  3. Cancer Reporting Rule R384-100 R384. Health, Community Health Services, Chronic Disease.

    E-Print Network [OSTI]

    Tipple, Brett

    Cancer Reporting Rule R384-100 R384. Health, Community Health Services, Chronic Disease. R384-100. Cancer Reporting Rule R384-100-1. Purpose Statement (1) The Cancer Reporting Rule is adopted under authority of sections 26-1-30 and 26-5-3. (2) Cancers Constitute a leading cause of morbidity and mortality

  4. Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and

    E-Print Network [OSTI]

    Rosenberg, Michael S.

    Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and geographic We have previously shown that geographic differences in cancer mortalities in Europe are related of 45 male and 47 female cancers. Differences in cancer incidences are correlated moder- ately, first

  5. RESEARCH Open Access Analysis of primary risk factors for oral cancer

    E-Print Network [OSTI]

    Ahmad, Sajjad

    RESEARCH Open Access Analysis of primary risk factors for oral cancer from select US states , Michelle Chino3 , Karl Kingsley1* Abstract Objectives: To examine the primary risk factor for oral cancer in oral cancer incidence and mortality. Methods: Population-based data on oral cancer morbidity

  6. Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 19952007 (the

    E-Print Network [OSTI]

    Maizels, Rick

    1 Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995­2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data M P Coleman Background Cancer survival is a key measure of the effectiveness of health-care systems. Persistent regional

  7. Cancer, Palliative and End of Life Care ResearchProjects2012

    E-Print Network [OSTI]

    Anderson, Jim

    Cancer, Palliative and End of Life Care ResearchProjects2012 #12;2 5 4 Cancer, Palliative and End and students working together to transform care and improve outcomes for individuals affected by cancer, other the right questions to generate theory, influence policy and change practice. Cancer survivorship

  8. AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day

    E-Print Network [OSTI]

    Sherman, S. Murray

    AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day www.cancerprogressreport.org · www.aacr.org #12;AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day www.cancerprogressreport.org · www.aacr.org Also published as: American Association for Cancer Research. AACR cancer progress report

  9. Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14)

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14 is that this behavior is extremely unhealthy and risky for their bodies, specifically their skin. Skin cancer is the most common form of cancer found in young adults and second most common cancer found in adolescents

  10. Cancer Therapy: Preclinical Modulating Endogenous NQO1 Levels Identifies Key Regulatory

    E-Print Network [OSTI]

    Gao, Jinming

    Pancreatic cancer is the fourth leading cause of cancer- related death in the United States. (1). Current cancer is the fourth leading cause of cancer-related deaths, in which the 5-year survival rate is less. Results: b-Lap­mediated cell death required $90 enzymatic units of NQO1. Essential downstream mediators

  11. TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors

    E-Print Network [OSTI]

    TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk mutations are observed in about 40e70% of lung cancer tissues, and the hot spot codon mu- tations factors that influence TP53 gene mutation in lung cancer patients residing areas with high lung cancer

  12. A filter-based feature selection approach for identifying potential biomarkers for lung cancer

    E-Print Network [OSTI]

    Lee, In-Hee; Lushington, Gerald H.; Visvanathan, Mahesh

    2011-03-21T23:59:59.000Z

    Background: Lung cancer is the leading cause of death from cancer in the world and its treatment is dependant on the type and stage of cancer detected in the patient. Molecular biomarkers that can characterize the cancer phenotype are thus a key...

  13. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

    E-Print Network [OSTI]

    Cai, Long

    Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer, Timothy Anderson6, Norman Gerry7, Joseph Keane4, Marc E Lenburg7 & Jerome S Brody1 Lung cancer smokers with suspicion of lung cancer could be used as a lung cancer biomarker. Using a training set (n

  14. Sandia National Laboratories: BASF latent curing epoxy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Manufacturing Initiative (AMI) is a multiple-year, 3-way collaboration among TPI Composites, Iowa State University, and Sandia National Laboratories. The goal of this...

  15. Latent ion tracks in amorphous silicon

    SciTech Connect (OSTI)

    Bierschenk, Thomas [Australian National University, Canberra, Australia] [Australian National University, Canberra, Australia; Giulian, Raquel [Australian National University, Canberra, Australia] [Australian National University, Canberra, Australia; Afra, Boshra [Australian National University, Canberra, Australia] [Australian National University, Canberra, Australia; Rodriguez, Matias D [Australian National University, Canberra, Australia] [Australian National University, Canberra, Australia; Schauries, D [Australian National University, Canberra, Australia] [Australian National University, Canberra, Australia; Mudie, Stephen [Australian Synchrotron] [Australian Synchrotron; Pakarinen, Olli H [ORNL] [ORNL; Djurabekova, Flyura [University of Helsinki] [University of Helsinki; Nordlund, Kai [University of Helsinki] [University of Helsinki; Osmani, Orkhan [University of Duisburg-Essen, Germany] [University of Duisburg-Essen, Germany; Medvedev, Nikita [University of Kaiserslautern, Germany] [University of Kaiserslautern, Germany; Rethfield, Baerbel [University of Kaiserslautern, Germany] [University of Kaiserslautern, Germany; Ridgway, Mark C [Australian National University, Canberra, Australia] [Australian National University, Canberra, Australia; Kluth, Patrick [Australian National University, Canberra, Australia] [Australian National University, Canberra, Australia

    2013-01-01T23:59:59.000Z

    We present experimental evidence for the formation of ion tracks in amorphous Si induced by swift heavy ion irradiation. An underlying core-shell structure consistent with remnants of a high density liquid structure was revealed by small-angle x-ray scattering and molecular dynamics simulations. Ion track dimensions dier for as-implanted and relaxed Si as attributed to dierent microstructures and melting temperatures. The identication and characterisation of ion tracks in amorphous Si yields new insight into mechanisms of damage formation due to swift heavy ion irradiation in amorphous semiconductors.

  16. Latent feature models for dyadic prediction /

    E-Print Network [OSTI]

    Menon, Aditya Krishna

    2013-01-01T23:59:59.000Z

    2 edition. Airoldi, E. , Blei, D. M. , Fienberg, S. E. , andInc. , Secaucus, NJ, USA. Blei, D. M. and McAuliffe, J. D. (was studied previously in (Blei and McAuliffe, 2010). The

  17. Nonlinear Latent Variable Models for Video Sequences

    E-Print Network [OSTI]

    rahimi, ali

    2005-06-06T23:59:59.000Z

    Many high-dimensional time-varying signals can be modeled as a sequence of noisy nonlinear observations of a low-dimensional dynamical process. Given high-dimensional observations and a distribution describing the ...

  18. Latent feature models for dyadic prediction /

    E-Print Network [OSTI]

    Menon, Aditya Krishna

    2013-01-01T23:59:59.000Z

    prediction . . . . . . . . . . . . . . . . . . . . . . . . .Response prediction . . . . . . . . . . . . . . . . . . .2.4.3 Weighted link prediction . . . . . .

  19. Diagnostic Performance of MRI for Assessing Tumor Response in HER2 Negative Breast Cancer Receiving Neoadjuvant Chemotherapy Is Associated with Molecular Biomarker Profile

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    systemic treatment of breast cancer. The Breast. 2005; 14:treatments after preoperative chemotherapy for breast cancer:well to the treatment. NAC-treated breast cancers having a

  20. Anti-Tumor Effect in Human Lung Cancer by a Combination Treatment of Novel Histone Deacetylase Inhibitors: SL142 or SL325 and Retinoic Acids

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    novel drugs for the treatment of cancer. Nat Rev Drug Discovepigenetic (and more) treatments for cancer. Nat Rev Cancera promising treatment for cancer. In this study, we

  1. Gene expression profiles in irradiated cancer cells

    SciTech Connect (OSTI)

    Minafra, L.; Bravatŕ, V.; Russo, G.; Ripamonti, M.; Gilardi, M. C. [IBFM CNR - LATO, Cefalů, Segrate (Italy)] [IBFM CNR - LATO, Cefalů, Segrate (Italy)

    2013-07-26T23:59:59.000Z

    Knowledge of the molecular and genetic mechanisms underlying cellular response to radiation may provide new avenues to develop innovative predictive tests of radiosensitivity of tumours and normal tissues and to improve individual therapy. Nowadays very few studies describe molecular changes induced by hadrontherapy treatments, therefore this field has to be explored and clarified. High-throughput methodologies, such as DNA microarray, allow us to analyse mRNA expression of thousands of genes simultaneously in order to discover new genes and pathways as targets of response to hadrontherapy. Our aim is to elucidate the molecular networks involved in the sensitivity/resistance of cancer cell lines subjected to hadrontherapy treatments with a genomewide approach by using cDNA microarray technology to identify gene expression profiles and candidate genes responsible of differential cellular responses.

  2. SOARCA Peach Bottom Atomic Power Station Long-Term Station Blackout Uncertainty Analysis: Convergence of the Uncertainty Results

    SciTech Connect (OSTI)

    Bixler, Nathan E.; Osborn, Douglas M.; Sallaberry, Cedric Jean-Marie; Eckert-Gallup, Aubrey Celia; Mattie, Patrick D.; Ghosh, S. Tina

    2014-02-01T23:59:59.000Z

    This paper describes the convergence of MELCOR Accident Consequence Code System, Version 2 (MACCS2) probabilistic results of offsite consequences for the uncertainty analysis of the State-of-the-Art Reactor Consequence Analyses (SOARCA) unmitigated long-term station blackout scenario at the Peach Bottom Atomic Power Station. The consequence metrics evaluated are individual latent-cancer fatality (LCF) risk and individual early fatality risk. Consequence results are presented as conditional risk (i.e., assuming the accident occurs, risk per event) to individuals of the public as a result of the accident. In order to verify convergence for this uncertainty analysis, as recommended by the Nuclear Regulatory Commission’s Advisory Committee on Reactor Safeguards, a ‘high’ source term from the original population of Monte Carlo runs has been selected to be used for: (1) a study of the distribution of consequence results stemming solely from epistemic uncertainty in the MACCS2 parameters (i.e., separating the effect from the source term uncertainty), and (2) a comparison between Simple Random Sampling (SRS) and Latin Hypercube Sampling (LHS) in order to validate the original results obtained with LHS. Three replicates (each using a different random seed) of size 1,000 each using LHS and another set of three replicates of size 1,000 using SRS are analyzed. The results show that the LCF risk results are well converged with either LHS or SRS sampling. The early fatality risk results are less well converged at radial distances beyond 2 miles, and this is expected due to the sparse data (predominance of “zero” results).

  3. Improved mehtods and reagents for pretargeted radioimmunotherapy of cancer

    E-Print Network [OSTI]

    Zajic, Stefan C

    2007-01-01T23:59:59.000Z

    Pretargeted radioimmunotherapy (PRIT) of cancer improves upon conventional radioimmunotherapy (RIT) by decoupling the pharmacokinetics of the targeting agent and the radioisotope. In order to improve upon PRIT, we have ...

  4. The Energy Landscape Analysis of Cancer Mutations in Protein Kinases

    E-Print Network [OSTI]

    Dixit, Anshuman; Verkhivker, Gennady M.

    2011-10-06T23:59:59.000Z

    The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases. In the present ...

  5. Genomics at the Ontario Institute for Cancer Research

    SciTech Connect (OSTI)

    Ali, Johar [Ontario Institute for Cancer Research

    2010-06-02T23:59:59.000Z

    Johar Ali of the Ontario Institute for Cancer Research discusses genomics and next-gen applications at the OICR on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  6. Text Mining in Cancer Gene and Pathway Prioritization

    E-Print Network [OSTI]

    Riedlinger, Gregory

    Prioritization of cancer implicated genes has received growing attention as an effective way to reduce wet lab cost by computational analysis that ranks candidate genes according to the likelihood that experimental ...

  7. Cell Death Pathways in Photodynamic Therapy of Cancer

    E-Print Network [OSTI]

    Mroz, Pawel

    Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ...

  8. Introduction Prostate cancer has the highest incidence of any malig-

    E-Print Network [OSTI]

    Boyer, Edmond

    -dependent to androgen-independent tumors (2). In the case of metastasis, androgen sup- pression is the leading treatment of cancer-related deaths in men in industrialized countries (1). Besides metas- tasis to bone and lymph

  9. Breast cancer incidence following preeclampsia or gestational hypertension

    E-Print Network [OSTI]

    Wormuth, Jennifer Karen

    1997-01-01T23:59:59.000Z

    A retrospective cohort study was conducted to examine the relationship between preeclampsia or gestational hypertension and subsequent breast cancer in a population of 6,564 pregnant women. Data on the study population came from the Child Health...

  10. All-codon scanning identifies p53 cancer rescue mutations

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    interactions by alanine-scanning mutagenesis. Science, 244,10.1093/nar/gkq571 All-codon scanning identifies p53 cancer2010 ABSTRACT In vitro scanning mutagenesis strategies are

  11. anal cancer treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    22 23 24 25 Next Page Last Page Topic Index 1 Treatment and outcome of anal cancer in Norway . Open Access Theses and Dissertations Summary: ??Avhandlingen er basert p komplette...

  12. antiangiogenic cancer therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    thyroid cancer, sup 3 sup 2 P for policytemi vera, sup 8 sup 9 Sr and sup 1 sup 5 sup 3 Sm for palliative treatments. There are differences between the hospitals how the...

  13. Cancer Cell of Origin: Spotlight on Luminal Progenitors

    E-Print Network [OSTI]

    Chaffer, Christine L.

    Does basal type breast cancer arise from oncogenic transformation of a basal cell type? In this issue of Cell Stem Cell, Molyneux et al. (2010) investigate the provenance of the basal-type BRCA1 breast carcinoma and come ...

  14. The use of polarized light for skin cancer detecton 

    E-Print Network [OSTI]

    DeLaughter, Aimee Hill

    2002-01-01T23:59:59.000Z

    detection system. Presented here is a method for the optical determination of cancerous tissue using polarized light. This thesis describes the development of a polarimetric imaging system including its calibration and testing. In addition, experiments...

  15. Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Print Immortality is not a good thing for cells, and in fact, cells will destroy themselves in a process called...

  16. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism...

  17. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  18. Nested methylation-specific polymerase chain reaction cancer detection method

    DOE Patents [OSTI]

    Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

    2007-05-08T23:59:59.000Z

    A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

  19. Technology "Relay Race" Against Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GE Scientists in Technology "Relay Race" Against Cancer Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new...

  20. Tumour microenvironment interactions of small cell lung cancer

    E-Print Network [OSTI]

    Hodkinson, Philip Simon

    2009-01-01T23:59:59.000Z

    Small cell lung cancer (SCLC) is characterised by rapid growth, early metastatic spread and poor long-term survival. The tumour is initially sensitive to chemotherapy and thus objective response rates are high. Unfortunately, ...

  1. Investigating immune surveillance, tolerance, and therapy in cancer

    E-Print Network [OSTI]

    Cheung, Ann F

    2009-01-01T23:59:59.000Z

    Maximizing the potential of cancer immunotherapy requires model systems that closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems ...

  2. Systems consequences of amplicon formation in human breast cancer

    E-Print Network [OSTI]

    Inaki, Koichiro

    Chromosomal structural variations play an important role in determining the transcriptional landscape of human breast cancers. To assess the nature of these structural variations, we analyzed eight breast tumor samples ...

  3. antibodies targeting cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of an NF-B responsive element (pNF-B- Luc) encapsulated in a PRb peptide functionalized stealth targeted systems. In addition, we constructed a novel cancer therapeutic plasmid...

  4. Novel mechanisms of endothelial-epithelial interactions underlying cancer metastasis

    E-Print Network [OSTI]

    Connor, Yamicia Doyasi

    2013-01-01T23:59:59.000Z

    Elucidation of molecular mechanisms underlying metastasis is the final frontier in cancer biology research. Identifying individual pathways in the metastatic cascade could lead to development of metastasis-specific ...

  5. ambulatory cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    confidence interval, 1.005 to 1.420). This J Korean; Soc Coloproctol; Ryung Ah Lee 43 New Knowledge. AT THE UCONN CANCER CENTER, patients can benefit from the latest medical...

  6. anemic cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    confidence interval, 1.005 to 1.420). This J Korean; Soc Coloproctol; Ryung Ah Lee 31 New Knowledge. AT THE UCONN CANCER CENTER, patients can benefit from the latest medical...

  7. admitted cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 41 New Knowledge. AT THE UCONN CANCER CENTER, patients can benefit from the latest medical...

  8. advanced cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    confidence interval, 1.005 to 1.420). This J Korean; Soc Coloproctol; Ryung Ah Lee 65 New Knowledge. AT THE UCONN CANCER CENTER, patients can benefit from the latest medical...

  9. Analysis of alterations in the human cancer genome

    E-Print Network [OSTI]

    Carter, Scott L. (Scott Lambert)

    2011-01-01T23:59:59.000Z

    Aneuploidy, an abnormal complement of chromosomes, is present in approximately 90% of human malignancies. Despite over 100 years of research, many questions remain regarding the contribution of aneuploidy to the cancer ...

  10. PRECLINICAL STUDIES Cribrostatin 6 induces death in cancer cells through

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    (sometimes proceeded by bioreductive activation) [2­4], and others generate cellular reactive oxygen species death through the generation of reactive oxygen species.PRECLINICAL STUDIES Cribrostatin 6 induces death in cancer cells through a reactive oxygen species

  11. Targeting the tight junction : immunotherapy of colon cancer

    E-Print Network [OSTI]

    Ackerman, Margaret E

    2010-01-01T23:59:59.000Z

    A33 is a cell surface glycoprotein of colon epithelium with a long clinical history as a target in antibody-based cancer therapy. Despite being present in normal colon, radio-labeled antibodies against A33 are selectively ...

  12. Selectins Mediate Small Cell Lung Cancer Systemic Metastasis

    E-Print Network [OSTI]

    Heidemann, Franziska

    Metastasis formation is the major reason for the extremely poor prognosis in small cell lung cancer (SCLC) patients. The molecular interaction partners regulating metastasis formation in SCLC are largely unidentified, ...

  13. MicroRNA expression in canine mammary cancer

    E-Print Network [OSTI]

    Boggs, Rene' Michelle

    2008-10-10T23:59:59.000Z

    to act as both tumor suppressors and oncogenes in several different cancers, expression patterns of ten miRNAs (miR-15a, miR-16, miR-17-5p, miR-21, miR-29b, miR-125b, miR-145, miR-155, miR-181b, let-7f) known to be associated with human breast cancer were...

  14. Bone Cancer Rates in Dinosaurs Compared with Modern Vertebrates

    E-Print Network [OSTI]

    L. C. Natarajan; A. L. Melott; B. M. Rothschild; L. D. Martin

    2007-10-16T23:59:59.000Z

    Data on the prevalence of bone cancer in dinosaurs is available from past radiological examination of preserved bones. We statistically test this data for consistency with rates extrapolated from information on bone cancer in modern vertebrates, and find that there is no evidence of a different rate. Thus, this test provides no support for a possible role of ionizing radiation in the K-T extinction event.

  15. RSS Feeds Submit Biological Cancer Therapy There is hope. Learn more about biotherapy treatment options today. CancerCenter.com/CareThatNev

    E-Print Network [OSTI]

    Glaser, Rainer

    RSS Feeds » Submit Biological Cancer Therapy There is hope. Learn more about biotherapy treatment options today. CancerCenter.com/CareThatNev O li CNA C tifi ti Q i k d E S h f CNA N i P O li ! Home Earth of pesticides Scientists discover how to improve immune response to cancer at Princess Margaret Hospital Similar

  16. What is the probability that radiation caused a particular cancer

    SciTech Connect (OSTI)

    Voelz, G.L.

    1983-01-01T23:59:59.000Z

    Courts, lawyers, health physicists, physicians, and others are searching for a credible answer to the question posed in the title of this paper. The cases in which the question arises frequently stem from an individual that has cancer and they, or their next-of-kin, are convinced that a past radiation exposure - usually small - is responsible for causing it. An arithmetic expression of this problem is simple: the probability of causation by the radiation dose in question is equal to the risk of cancer from the radiation dose divided by the risk of cancer from all causes. The application of risk factors to this equation is not so simple. It must involve careful evaluation of the reliability of and variations in risk coefficients for development of cancer due to radiation exposure, other carcinogenic agents, and natural causes for the particular individual. Examination of our knowledge of these various factors indicates that a large range in the answers can result due to the variability and imprecision of the data. Nevertheless, the attempts to calculate and the probability that radiation caused the cancer is extremely useful to provide a gross perspective on the probability of causation. It will likely rule in or out a significant number of cases despite the limitations in our understandings of the etiology of cancer and the risks from various factors. For the remaining cases, a thoughtful and educated judgment based on selected data and circumstances of the case will also be needed before the expert can develop and support his opinion.

  17. Carbon Ion Radiotherapy At Gunma University: Currently Indicated Cancer And Estimation Of Need

    SciTech Connect (OSTI)

    Ohno, Tatsuya; Nakano, Takashi; Kanai, Tatsuaki; Yamada, Satoru [Gunma University Heavy Ion Medical Center, Gunma University, 3-39-22 Showa, Maebashi 371-8511 (Japan)

    2011-06-01T23:59:59.000Z

    Carbon ion radiotherapy for the first patient at Gunma University Heavy Ion Medical Center (GHMC) was initiated in March of 2010. The major specifications of the facility were determined based on the experience of clinical treatments at National Institute of Radiological Sciences (NIRS). The currently indicated sites of cancer treatment at GHMC are lung, prostate, head and neck, liver, rectum, bone and soft tissue. In order to evaluate the potential need for treatment in the region including Gunma prefecture and the adjacent 4 prefectures, an estimation model was constructed based on the Japanese cancer registration system, regular structure surveys by the Cancer Societies, and published articles on each cancer type. Carbon ion RT was potentially indicated for 8,085 patients and realistically for 1,527 patients, corresponding to 10% and 2% of the newly diagnosed cancer patients in the region. Prostate cancer (541 patients) followed by lung cancer (436 patients), and liver cancer (313 patients) were the most commonly diagnosed cancers.

  18. Inhibitor Complexes of the Pseudomonas Serine-Carboxyl Proteinase Alexander Wlodawer,*, Mi Li,, Alla Gustchina, Zbigniew Dauter,| Kenichi Uchida, Hiroshi Oyama,#

    E-Print Network [OSTI]

    Support Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, when mutated, leads to a fatal human neurodegenerative disease, classical late-infantile neuronal

  19. Accelerated hypofractionated radiation therapy compared to conventionally fractionated radiation therapy for the treatment of inoperable non-small cell lung cancer

    E-Print Network [OSTI]

    Amini, Arya; Lin, Steven H; Wei, Caimiao; Allen, Pamela; Cox, James D; Komaki, Ritsuko

    2012-01-01T23:59:59.000Z

    of inoperable non-small cell lung cancer. Radiation Oncologystage iii non-small cell lung cancer: randomized phase IIIfactors for non-small cell lung cancer. Lung Cancer 1997,

  20. In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    P61A6 on non-small cell lung cancer cells. BMC Cancer 2013in mice with K-RAS-induced lung cancer. J Clin Invest 2007,advances in non-small cell lung cancer biology and clinical

  1. BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer

    E-Print Network [OSTI]

    Kwan, Johnson

    2010-01-01T23:59:59.000Z

    in a case of post-Chernobyl childhood thyroid cancer *D. Thyroid cancer after Chernobyl. Nature 1992;359:21-22. [LN. Thyroid cancer after Chernobyl. Nature [4] Gembicki M,

  2. Expression of Phosphorylated Raf Kinase Inhibitor Protein (pRKIP) is a Predictor of Lung Cancer Survival

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    pRKIP) is a predictor of lung cancer survival Sara Huerta-RKIP and phospho-RKIP in human lung cancer tissue microarrayand in those with early stage lung cancer. Conclusions: This

  3. Evaluation of Irinotecan as a Third- or Fourth-line Treatment for Advanced Non-small Cell Lung Cancer

    E-Print Network [OSTI]

    Keener, James

    2013-01-01T23:59:59.000Z

    Advanced Non–Small-Cell Lung Cancer: An Individual PatientChemotherapy of Non-Small Cell Lung Cancer in the Elderly."Lung Cancer 38, Supplement 3.0 (2002): 67-70. Print. "

  4. Cellular response to 11[beta]-dichloro, a novel aniline mustard-estradienone, in various prostate cancer cell lines

    E-Print Network [OSTI]

    González, Francis Héber

    2009-01-01T23:59:59.000Z

    Cancer is a group of diseases characterized by uncontrolled cell growth and abnormal cell cycle and apoptosis regulation. Among the types of cancer, prostate cancer is the leading cause of death in men. Although many ...

  5. Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells

    SciTech Connect (OSTI)

    Hamada, Shin [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan); Masamune, Atsushi, E-mail: amasamune@med.tohoku.ac.jp [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan); Takikawa, Tetsuya; Suzuki, Noriaki; Kikuta, Kazuhiro; Hirota, Morihisa [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan); Hamada, Hirofumi [Laboratory of Oncology, Department of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji (Japan)] [Laboratory of Oncology, Department of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji (Japan); Kobune, Masayoshi [Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo (Japan)] [Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo (Japan); Satoh, Kennichi [Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori (Japan)] [Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori (Japan); Shimosegawa, Tooru [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)

    2012-05-04T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Pancreatic stellate cells (PSCs) promote the progression of pancreatic cancer. Black-Right-Pointing-Pointer Pancreatic cancer cells co-cultured with PSCs showed enhanced spheroid formation. Black-Right-Pointing-Pointer Expression of stem cell-related genes ABCG2, Nestin and LIN28 was increased. Black-Right-Pointing-Pointer Co-injection of PSCs enhanced tumorigenicity of pancreatic cancer cells in vivo. Black-Right-Pointing-Pointer This study suggested a novel role of PSCs as a part of the cancer stem cell niche. -- Abstract: The interaction between pancreatic cancer cells and pancreatic stellate cells (PSCs), a major profibrogenic cell type in the pancreas, is receiving increasing attention. There is accumulating evidence that PSCs promote the progression of pancreatic cancer by increasing cancer cell proliferation and invasion as well as by protecting them from radiation- and gemcitabine-induced apoptosis. Recent studies have identified that a portion of cancer cells, called 'cancer stem cells', within the entire cancer tissue harbor highly tumorigenic and chemo-resistant phenotypes, which lead to the recurrence after surgery or re-growth of the tumor. The mechanisms that maintain the 'stemness' of these cells remain largely unknown. We hypothesized that PSCs might enhance the cancer stem cell-like phenotypes in pancreatic cancer cells. Indirect co-culture of pancreatic cancer cells with PSCs enhanced the spheroid-forming ability of cancer cells and induced the expression of cancer stem cell-related genes ABCG2, Nestin and LIN28. In addition, co-injection of PSCs enhanced tumorigenicity of pancreatic cancer cells in vivo. These results suggested a novel role of PSCs as a part of the cancer stem cell niche.

  6. Cancer Systems Biology Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon,

    E-Print Network [OSTI]

    Smith, V Anne

    245 Chapter 12 Cancer Systems Biology Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon+Business Media, LLC 2010 #12;246 Faratian et al. While cancer can arise from any cell in the body, the commonest

  7. KISS1 and Its G Protein-Coupled Receptor (GPR54) in Cancer Progression and Metastasis

    E-Print Network [OSTI]

    Cho, Sunggook Gook

    2012-02-14T23:59:59.000Z

    in cancer progression is still unclear. This study demonstrates that an autocrine GPR54 signaling regulates breast cancer progression and metastasis. When MMTV-PyMT mice were crossed with Gpr54 heterozygous mice, Gpr54 heterozygosity attenuated Py...

  8. Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

    E-Print Network [OSTI]

    Zhang, GuangJun

    The identification of cancer drivers is a major goal of current cancer research. Finding driver genes within large chromosomal events is especially challenging because such alterations encompass many genes. Previously, we ...

  9. A general method for studying autocrine signaling and its impact on cancer cell growth

    E-Print Network [OSTI]

    Sampattavanich, Somponnat

    2011-01-01T23:59:59.000Z

    Autocrine signaling plays essential roles in providing self-sustaining growth signals to cancer cells. Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine signaling in cancer medicine ...

  10. Mechanisms of Action of Metformin as an Anti-cancer Agent

    E-Print Network [OSTI]

    Ramachandran Nair Vasanthakum, Vijayalekshmi

    2014-08-13T23:59:59.000Z

    Cancer is the second leading cause of death worldwide and epidemiological studies suggest the association of diabetes mellitus with an enhanced risk for multiple cancers. Metformin (1,1-dimethylbiguanide hydrochloride) is the most widely prescribed...

  11. Molecular biomarker discovery and physiological assessment of skeletal muscle in cancer cachexia 

    E-Print Network [OSTI]

    Stephens, Nathan Andrew

    2014-07-05T23:59:59.000Z

    Cachexia affects up to two thirds of all cancer patients with progressive disease. It is a syndrome characterised by weight-loss, anorexia, fatigue, asthenia, peripheral oedema, and is responsible for around 20% of cancer ...

  12. Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    ascorbic acid to prevent and treat cancer-associated sepsis?value of i.v. AA in cancer treat- ment is controversial. Inpatients to prevent/treat SIRS. There is an additional

  13. Pomegranate Juice and Pomegranate Derived Natural Products as Alternative Treatment for Cancer Progression and Metastasis

    E-Print Network [OSTI]

    Wang, Lei

    2013-01-01T23:59:59.000Z

    and the G2-M checkpoint in MDA-MB-231 breast cancer cells.MCF-7) and ER negative (MB-MDA-231) breast cancer cell linespomegranate treatment than MB-MDA-231 cells. The seed oil

  14. Nuclear Factor I/B is an Oncogene in Small Cell Lung Cancer

    E-Print Network [OSTI]

    Dooley, Alison L.

    Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. ...

  15. Socioeconomic status and prostate cancer incidence and mortality rates among the diverse population of California

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    MN, Smith E, Siadaty M, Hauck FR, Pickle LW (2006) Spatial analysis of prostate cancer incidence and race in Virginia,

  16. Regulation of E2F-1 gene expression in human breast cancer cells

    E-Print Network [OSTI]

    Ngwenya, Sharon Khethiwe

    2005-08-29T23:59:59.000Z

    among women in the Western world, second to lung cancer. And in 2003, approximately 39,800 women died as a result of breast cancer (10). The reported incidence of breast cancer has risen during recent years due to the increase of mammography... likely to be initiated, i.e. early adulthood and reproductive years, and increased breast cancer risk (17). However, other studies have reported that estrogens are able to induce direct and indirect free radical-mediated DNA damage, genetic...

  17. Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway

    SciTech Connect (OSTI)

    Ahn, Hee-Jin [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of)] [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of); Kim, Gwangil [Department of Pathology, CHA Bundang Medical Center, CHA University, Seoul (Korea, Republic of)] [Department of Pathology, CHA Bundang Medical Center, CHA University, Seoul (Korea, Republic of); Park, Kyung-Soon, E-mail: kspark@cha.ac.kr [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of)] [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of)

    2013-08-09T23:59:59.000Z

    Highlights: •Ell3 enhances proliferation and drug resistance of breast cancer cell lines. •Ell3 is related to the cancer stem cell characteristics of breast cancer cell lines. •Ell3 enhances oncogenicity of breast cancer through the ERK1/2 signaling pathway. -- Abstract: Ell3 is a RNA polymerase II transcription elongation factor that is enriched in testis. The C-terminal domain of Ell3 shows strong similarities to that of Ell (eleven?nineteen lysine-rich leukemia gene), which acts as a negative regulator of p53 and regulates cell proliferation and survival. Recent studies in our laboratory showed that Ell3 induces the differentiation of mouse embryonic stem cells by protecting differentiating cells from apoptosis via the promotion of p53 degradation. In this study, we evaluated the function of Ell3 in breast cancer cell lines. MCF-7 cell lines overexpressing Ell3 were used to examine cell proliferation and cancer stem cell properties. Ectopic expression of Ell3 in breast cancer cell lines induces proliferation and 5-FU resistance. In addition, Ell3 expression increases the cancer stem cell population, which is characterized by CD44 (+) or ALDH1 (+) cells. Mammosphere-forming potential and migration ability were also increased upon Ell3 expression in breast cancer cell lines. Through biochemical and molecular biological analyses, we showed that Ell3 regulates proliferation, cancer stem cell properties and drug resistance in breast cancer cell lines partly through the MEK?extracellular signal-regulated kinase signaling pathway. Murine xenograft experiments showed that Ell3 expression promotes tumorigenesis in vivo. These results suggest that Ell3 may play a critical role in promoting oncogenesis in breast cancer by regulating cell proliferation and cancer stem cell properties via the ERK1/2 signaling pathway.

  18. Information Needs of Young Breast Cancer Patients with Early Menopause Symptoms Alisha D. Allison1

    E-Print Network [OSTI]

    Zhou, Yaoqi

    and Janet S. Carpenter1 Department of Adult Health, IU School of Nursing1 Breast cancer treatments can cause to the study, the women were asked to provide demographic and cancer treatment information and complete a semi cancer patients will need before treatment decisions are made. These findings will help medical

  19. ADVANCING A HEALTHIER WISCONSIN ENDOWMENT: RESEARCH AND EDUCATION PROGRAM Pancreatic Cancer Research Program

    E-Print Network [OSTI]

    cancer biology suggest that a single treatment approach for this heterogeneous and biologically complex cancer is not ideal. In the future, the best treatments may be determined by the molecular determinantsADVANCING A HEALTHIER WISCONSIN ENDOWMENT: RESEARCH AND EDUCATION PROGRAM Pancreatic Cancer

  20. ANTI-ANGIOGENIC THERAPY IN CANCER TREATMENT AS AN OPTIMAL CONTROL PROBLEM

    E-Print Network [OSTI]

    Schaettler, Heinz

    ANTI-ANGIOGENIC THERAPY IN CANCER TREATMENT AS AN OPTIMAL CONTROL PROBLEM URSZULA LEDZEWICZ AND HEINZ SCH¨ATTLER Abstract. Anti-angiogenic therapy is a novel treatment approach in cancer therapy. Key words. optimal control, geometric methods, cancer treatment, anti-angiogenic therapy AMS subject