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Sample records for kuwait gp guadeloupe

  1. Guadeloupe: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Country Profile Name Guadeloupe Population Unavailable GDP Unavailable Energy Consumption 0.03 Quadrillion Btu 2-letter ISO code GP 3-letter ISO code GLP Numeric ISO...

  2. Kuwait Petroleum Corporation | Open Energy Information

    Open Energy Info (EERE)

    in the world. The corporation brings all state-owned corporations under one corporate umbrella. References "Kuwait Petroeum Corporation" "About KPC" Retrieved from "http:...

  3. U.S. Energy Secretary Visits Kuwait | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Kuwait U.S. Energy Secretary Visits Kuwait November 15, 2005 - 2:30pm Addthis Stop included meeting with U.S. business leaders and military troops KUWAIT CITY, KUWAIT - On Monday, November 14, 2005, U.S. Department of Energy Secretary Samuel W. Bodman toured the EQUATE petrochemical plant and met with U.S. business representatives while visiting Kuwait, as part of his trip through the Middle East. The EQUATE petrochemical plant is a joint venture between Kuwait's Petrochemical Industries Company

  4. Kuwait: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Country Profile Name Kuwait Population 2,213,403 GDP 173,438,000,000 Energy Consumption 1.19 Quadrillion Btu 2-letter ISO code KW 3-letter ISO code KWT Numeric ISO...

  5. GP Solarpark | Open Energy Information

    Open Energy Info (EERE)

    GP Solarpark provides project engineering, construction and establishment of photovoltaic power plants. References: GP Solarpark1 This article is a stub. You can help...

  6. G&..p

    Office of Legacy Management (LM)

    pA,2-), (0 ' i . .I fi;' G&..p -1 Deparrnent of Elergy ?a Fhc&;Opcrst ions I - dak Ridgc,Tennessee 7830 Mr. Roy Bjuvik,x' Rohm and Haas t,Company 5000 Richmond Street...

  7. ARM - Instrument - gp

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    you Send us a note below or call us at 1-888-ARM-DATA. Send Instrument : Global Positioning System (GP) <-- Picture of the Global Positioning System (GPS) --> General...

  8. Successful operation of a large LPG plant. [Kuwait

    SciTech Connect (OSTI)

    Shtayieh, S.; Durr, C.A.; McMillan, J.C.; Collins, C.

    1982-03-01

    The LPG plant located at Mina-Al Ahmadi, Kuwait, is the heart of Kuwait Oil Co.'s massive Gas Project to use the associated gas from Kuwait's oil production. Operation of this three-train plant has been very successful. A description is given of the three process trains consisting of four basic units: extraction, fractionation, product treating, and refrigeration. Initial problems relating to extraction, fractionation, product treating and, refrigeration are discussed. 1 ref.

  9. Energy Transition Initiative: Island Energy Snapshot - Guadeloupe; NREL (National Renewable Energy Laboratory)

    SciTech Connect (OSTI)

    2015-05-27

    This profile provides a snapshot of the energy landscape of Guadeloupe, an overseas region of France located in the eastern Caribbean Sea. Guadeloupe’s utility rates are approximately $0.18 U.S. dollars (USD) per kilowatt-hour (kWh), below the Caribbean regional average of $0.33 USD/kWh.

  10. EA-319 Fortis Energy Marketing & Trading GP | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fortis Energy Marketing & Trading GP EA-319 Fortis Energy Marketing & Trading GP Order authorizing Fortis Energy Marketing & Trading GP to export electric energy to Canada PDF ...

  11. GP Batteries International Limited | Open Energy Information

    Open Energy Info (EERE)

    International Limited is principally engaged in the development, manufacture and marketing of batteries and battery-related products. References: GP Batteries International...

  12. EA-319-A Fortis Energy Marketing & Trading GP (BNP Paribas Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    -A Fortis Energy Marketing & Trading GP (BNP Paribas Energy Trading GP) EA-319-A Fortis Energy Marketing & Trading GP (BNP Paribas Energy Trading GP) Order authorizing Fortis ...

  13. EA-319-A Fortis Energy Marketing & Trading GP (BNP Paribas Energy Trading

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    GP) | Department of Energy -A Fortis Energy Marketing & Trading GP (BNP Paribas Energy Trading GP) EA-319-A Fortis Energy Marketing & Trading GP (BNP Paribas Energy Trading GP) Order authorizing Fortis Energy Marketing & Trading GP (BNP Paribas Energy Trading GP) to export electric energy to Canada PDF icon EA-319-A Fortis Energy Marketing & Trading GP (BNP Paribas Energy Trading GP) More Documents & Publications EA-319 Fortis Energy Marketing & Trading GP Listing of

  14. Secretary of Energy Samuel W. Bodman Meets with U.S. Troops in Kuwait

    Broader source: Energy.gov [DOE]

    ARIFJAN, KUWAIT - U.S. Secretary of Energy Samuel Bodman and his wife Diane Bodman had dinner and conversed with Pfc. James Clark, Logistics Task Force 28, Capt. Zachary Lange, Headquarters and...

  15. Hyperion 5113/GP Infrasound Sensor Evaluation.

    SciTech Connect (OSTI)

    Merchant, Bion J.

    2015-08-01

    Sandia National Laboratories has tested and evaluated an infrasound sensor, the 5113/GP manufactured by Hyperion. These infrasound sensors measure pressure output by a methodology developed by the University of Mississippi. The purpose of the infrasound sensor evaluation was to determine a measured sensitivity, transfer function, power, self-noise, dynamic range, and seismic sensitivity. These sensors are being evaluated prior to deployment by the U.S. Air Force.

  16. NNSA Signs Memorandum with Kuwait to Increase Cooperation on Nuclear Safeguards and Nonproliferation

    ScienceCinema (OSTI)

    Thomas D'Agostino

    2010-09-01

    On June 23, 2010, the National Nuclear Security Administration (NNSA) signed a Memorandum of Cooperation on nuclear safeguards and other nonproliferation topics with the Kuwait National Nuclear Energy Committee (KNNEC). NNSA Administrator Thomas D'Agostino and KNNEC's Secretary General, Dr. Ahmad Bishara, signed the memorandum at a ceremony at U.S. Department of Energy headquarters in Washington.

  17. YEAR","MONTH","STATE","UTILITY_ID","UTILITY_NAME","RESIDENTIAL_GP REVENUES (Tho

    U.S. Energy Information Administration (EIA) Indexed Site

    UTILITY_ID","UTILITY_NAME","RESIDENTIAL_GP REVENUES (Thousand $)","COMMERCIAL_GP REVENUES (Thousand $)","INDUSTRIAL_GP REVENUES (Thousand $)","TRANS_GP REVENUES (Thousand $)","TOTAL_GP REVENUES (Thousand $)","RESIDENTIAL_GP SALES (MWh)","COMMERCIAL_GP SALES (MWh)","INDUSTRIAL_GP SALES (MWh)","TRANS_GP SALES (MWh)","TOTAL_GP SALES (MWh)","RESIDENTIAL_GP

  18. Boston Power GP Batteries JV | Open Energy Information

    Open Energy Info (EERE)

    Taiwan-based JV that produces Sonata rechargeable Li-ion batteries for laptop computers. References: Boston Power & GP Batteries JV1 This article is a stub. You can help...

  19. Assessment of damage to the desert surfaces of Kuwait due to the Gulf War

    SciTech Connect (OSTI)

    El-Baz, F. . Center for Remote Sensing); Al-Ajmi, D. . Environmental and Earth Sciences Div.)

    1993-01-01

    This is a preliminary report on a joint research project by Boston University and the Kuwait Institute for Scientific Research that commenced in April 1992. The project aim is to establish the extent and nature of environmental damage to the desert surface and coastal zone of Kuwait due to the Gulf War and its aftermath. Change detection image enhancement techniques were employed to enhance environmental change by comparison of Landsat Thematic Mapper images obtained before the wars and after the cessation of the oil and well fires. Higher resolution SPOT images were also utilized to evaluate the nature of the environmental damage to specific areas. The most prominent changes were due to: (1) the deposition of oil and course-grained soot on the desert surface as a result of oil rain'' from the plume that emanated from the oil well fires; (2) the formation of hundreds of oil lakes, from oil seepage at the damaged oil well heads; (3) the mobilization of sand and dust and (4) the pollution of segments of the coastal zone by the deposition of oil from several oil spills. Interpretation of satellite image data are checked in the field to confirm the observations, and to assess the nature of the damage. Final results will be utilized in establishing the needs for remedial action to counteract the harmful effects of the various types of damage to the environment of Kuwait.

  20. Petroleum prices and profits in the 90 days following the invasion of Kuwait

    SciTech Connect (OSTI)

    Not Available

    1990-11-01

    For the third in the past 20 years the world has experienced an interruption in the flow of oil from the Persian Gulf. The Iraqi invasion of Kuwait on August 2, 1990, and shut down of Kuwait oil production capacity followed by the United Nations boycott of Iraqi oil removed 8 percent of the world's oil supply. The result was a sharp increase in the process of crude oil and petroleum products. These events raised numerous questions about the performance of energy markets and energy firms. This report supplies a first answer for some of those questions. At the time this report was prepared the invasion has been in effect for 90 days. Not all the data is available to fully answer every question. Some issues can only be completely resolved after more time has passed in which the invasion and its effects have had an opportunity to be fully assimilated. This report was specifically requested by W. Henson Moore, Deputy Secretary of Energy as a way of supplying the American public with what could be said about the current situation. Rumors abound and mixconceptions have proliferated. This report strives to give a proper perspective on some of the more vexing issues which the invasion produced. The Energy Information Administration (EIA) has addressed many questions in this report. By the way of summary these are the 10 most most frequently asked questions and EIA's quick answers. The page references tell the reader where to look in the report for further explanation. These are not the only issues addressed and EIA hopes that readers will be able to satisfy their curiosity about their own questions within the pages of this report.

  1. Structural Analysis of a Highly Glycosylated and Unliganded gp120-Based Antigen Using Mass Spectrometry

    SciTech Connect (OSTI)

    L Wang; Y Qin; S Ilchenko; J Bohon; W Shi; M Cho; K Takamoto; M Chance

    2011-12-31

    Structural characterization of the HIV-1 envelope protein gp120 is very important for providing an understanding of the protein's immunogenicity and its binding to cell receptors. So far, the crystallographic structure of gp120 with an intact V3 loop (in the absence of a CD4 coreceptor or antibody) has not been determined. The third variable region (V3) of the gp120 is immunodominant and contains glycosylation signatures that are essential for coreceptor binding and entry of the virus into T-cells. In this study, we characterized the structure of the outer domain of gp120 with an intact V3 loop (gp120-OD8) purified from Drosophila S2 cells utilizing mass spectrometry-based approaches. We mapped the glycosylation sites and calculated the glycosylation occupancy of gp120-OD8; 11 sites from 15 glycosylation motifs were determined as having high-mannose or hybrid glycosylation structures. The specific glycan moieties of nine glycosylation sites from eight unique glycopeptides were determined by a combination of ECD and CID MS approaches. Hydroxyl radical-mediated protein footprinting coupled with mass spectrometry analysis was employed to provide detailed information about protein structure of gp120-OD8 by directly identifying accessible and hydroxyl radical-reactive side chain residues. Comparison of gp120-OD8 experimental footprinting data with a homology model derived from the ligated CD4-gp120-OD8 crystal structure revealed a flexible V3 loop structure in which the V3 tip may provide contacts with the rest of the protein while residues in the V3 base remain solvent accessible. In addition, the data illustrate interactions between specific sugar moieties and amino acid side chains potentially important to the gp120-OD8 structure.

  2. Pacific Northwest Laboratory Gulfstream I measurements of the Kuwait oil-fire plume, July--August 1991

    SciTech Connect (OSTI)

    Busness, K.M.; Hales, J.M.; Hannigan, R.V.; Thorp, J.M.; Tomich, S.D.; Warren, M.J. ); Al-Sunaid, A.A. ); Daum, P.H.; Mazurek, M. )

    1992-11-01

    In 1991, the Pacific Northwest Laboratory conducted a series of aircraft measurements to determine pollutant and radiative properties of the smoke plume from oil fires in Kuwait. This work was sponsored by the US Department emanating of Energy, in cooperation with several other agencies as part of an extensive effort coordinated by the World Meteorological Organization, to obtain a comprehensive data set to assess the characteristics of the plume and its environmental impact. This report describes field measurement activities and introduces the various data collected, but provides only limited analyses of these data. Results of further data analyses will be presented in subsequent open-literature publications.

  3. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by

    Office of Scientific and Technical Information (OSTI)

    destabilizing the Env spike (Journal Article) | SciTech Connect Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Citation Details In-Document Search Title: Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Authors: Lee, Jeong Hyun ; Leaman, Daniel P. ; Kim, Arthur S. ; Torrents de la Peña, Alba ; Sliepen, Kwinten ; Yasmeen, Anila ; Derking, Ronald ; Ramos, Alejandra ; de Taeye, Steven W. ; Ozorowski,

  4. LEDS GP Success Story: Fostering Coordinated LEDS Support in Kenya (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2014-03-01

    The LEDS Global Partnership (LEDS GP) strives to advance climate-resilient, low-emission development through catalyzing collaboration, information exchange, and action on the ground. The Government of Kenya is a key LEDS GP member and offers an inspiring example of how LEDS GP is having an impact globally. The 2012 LEDS Collaboration in Action workshop in London provided an interactive space for members to share experiences on cross-ministerial LEDS leadership and to learn about concrete development impacts of LEDS around the world. Inspired by these stories, the Kenya's Ministry of State for Planning, National Development and Vision 2030 (MPND) began to collaborate closely with the Ministry of Environment and Mineral Resources to create strong links between climate change action and development in the country, culminating in the integration of Kenya's National Climate Change Action Plan and the country's Medium Term Development Plan.

  5. Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class

    Office of Scientific and Technical Information (OSTI)

    Antibodies in an HIV-1-Infected Chinese Donor (Journal Article) | SciTech Connect Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor Citation Details In-Document Search Title: Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor Authors: Kong, Leopold ; Ju, Bin ; Chen, Yajing ; He, Linling ; Ren, Li ; Liu, Jiandong ; Hong, Kunxue ; Su, Bin ; Wang, Zheng ;

  6. Production of monoclonal antibody (MoAB) CS-1 against platelet glycoprotein IIb-IIIa (GP IIb-IIIa)

    SciTech Connect (OSTI)

    Ramsamooj, P.; Morris, M.; Doellgast, G.; Hantgan, R.

    1987-05-01

    Platelet aggregation is mediated by the binding of fibrinogen (FGN) to the platelet GP IIb-IIIa complex. Receptor complex was purified from a solubilized platelet membrane fraction followed by lentil-lectin affinity chromatography and gel filtration. SDS-PAGE showed the product to be the complex, GP IIb-IIIa; light scattering intensity measurements indicated a Ca/sup 2 +/-dependent complex of the appropriate MW. Purified complex was then used to raise antibodies in Balb-c mice by standard hybridoma technology; positive cells were found by ELISA enabling the detection of antibody concentrations as low as 3 ng/ml. The MoABs were purified from both culture supernatant and ascites fluid by ion exchange and protein-A affinity chromatography. Western blotting determined that CS-1 is specific for nonreduced GP IIIa but not reduced GP IIIa or any form of GP IIb. CS-1 inhibited binding of radiolabeled FGN to ADP-stimulated platelets by 40-50% over a concentration range of 5-70 ..mu..g/ml. Flow cytometric analysis confirmed that CS-1 recognized a protein on the surface of both resting and stimulated platelets. The determined specificity of CS-1 and its limited ability to inhibit FGN binding to platelets make this MoAB useful for analysis of the structural and functional relationships between fibrin(ogen) and GP IIb-IIIa.

  7. sup 1 H and sup 31 P-NMR assignments of the non-exchangeable protons of the consensus acceptor exon:intron junction d(CpTpApCpApGpGpT)

    SciTech Connect (OSTI)

    Lown, J.W.; Chang, D.K.; Debart, F.; Rayner, B.; Imbach, J.L. )

    1986-06-01

    The consensus acceptor exon:intron junction d(CpTpApCpApGpGpT) has been synthesized by a modified phosphotriester method. The non-self complementary octamer exists in the single strand form in aqueous buffer at 20 degrees C as evidenced by temperature variable {sup 1}H-NMR and NOE measurements. The non-exchangeable proton assignments were secured using a combination of techniques including two-dimensional COSY, NOESY and the double quantum technique {sup 1}H-{sup 1}H-INADEQUATE as well as inversion recovery T1 experiments. The new technique of {sup 31}P-1H shift correlation is particularly valuable in removing certain ambiguities in the sugar proton assignments. Characteristic chemical shifts for the base protons which are determined by their immediate molecular environments are also useful in assignments. The consensus acceptor exon:intron junction adopts a random coil conformation in solution under the experimental conditions employed.

  8. GP-8 LAWS AND REGULATIONS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    40-DOP (5-2011) Supersedes (7-2010) issue DECLARATION of OCCUPATIONAL MEDICINE PROVIDER GENERAL INFORMATION PURPOSE All Contractors and their lower-tier subcontractors must comply with the Department of Energy's Worker Safety and Health Program regulation, 10 CFR 851, "Worker Safety and Health Program (WSHP). The WSHP enforces worker safety and health requirements including, but not limited to, standards of the Occupational Safety and Health Administration (OSHA), American National

  9. Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding

    SciTech Connect (OSTI)

    Pan, Ruimin; Chen, Yuxin; Vaine, Michael; Hu, Guangnan; Wang, Shixia; Lu, Shan; Kong, Xiang -Peng

    2015-07-15

    The fourth conserved region (C4) in the HIV-1 envelope glycoprotein (Env) gp120 is a structural element that is important for its function, as it binds to both the receptor CD4 and the co-receptor CCR5/CXCR4. It has long been known that this region is highly immunogenic and that it harbors B-cell as well as T-cell epitopes. It is the target of a number of antibodies in animal studies, which are called CD4-blockers. However, the mechanism by which the virus shields itself from such antibody responses is not known. Here, we determined the crystal structure of R53 in complex with its epitope peptide using a novel anti-C4 rabbit monoclonal antibody R53. Our data show that although the epitope of R53 covers a highly conserved sequence 433AMYAPPI439, it is not available in the gp120 trimer and in the CD4-bound conformation. Our results suggest a masking mechanism to explain how HIV-1 protects this critical region from the human immune system.

  10. Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Pan, Ruimin; Chen, Yuxin; Vaine, Michael; Hu, Guangnan; Wang, Shixia; Lu, Shan; Kong, Xiang -Peng

    2015-07-15

    The fourth conserved region (C4) in the HIV-1 envelope glycoprotein (Env) gp120 is a structural element that is important for its function, as it binds to both the receptor CD4 and the co-receptor CCR5/CXCR4. It has long been known that this region is highly immunogenic and that it harbors B-cell as well as T-cell epitopes. It is the target of a number of antibodies in animal studies, which are called CD4-blockers. However, the mechanism by which the virus shields itself from such antibody responses is not known. Here, we determined the crystal structure of R53 in complex with its epitopemore » peptide using a novel anti-C4 rabbit monoclonal antibody R53. Our data show that although the epitope of R53 covers a highly conserved sequence 433AMYAPPI439, it is not available in the gp120 trimer and in the CD4-bound conformation. Our results suggest a masking mechanism to explain how HIV-1 protects this critical region from the human immune system.« less

  11. NREL: Technology Transfer - Kuwait Visitors Interested in NREL...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to improve energy efficiency in their refining operations. KOC may also apply concentrated solar power technology to produce some of the steam needed in the company's operations...

  12. State of Kuwait Ministry of Oil | Open Energy Information

    Open Energy Info (EERE)

    of the rules or laws organizing the drilling and exploring process simultaneously with production and export operations and to protect such wealth for the next generations....

  13. Dynamically polarized target for the gp2 and GpE experiments at Jefferson Lab

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Pierce, J.; Maxwell, J.; Badman, T.; Brock, J.; Carlin, C.; Crabb, D. G.; Day, D.; Keith, C. D.; Kvaltine, N.; Meekins, D. G.; et al

    2013-12-16

    We describe a dynamically polarized target that has been utilized for two electron scattering experiments in Hall A at Jefferson Lab. The primary components of the target are a new, high cooling power 4 He evaporation refrigerator, and a re-purposed, superconducting split-coil magnet. It has been used to polarize protons in irradiated NH3 at a temperature of 1 K and at fields of 2.5 and 5.0 Tesla. The performance of the target material in the electron beam under these conditions will be discussed. The maximum polarizations of 28% and 95% were obtained at those fields, respectively. To satisfy the requirementsmore » of both experiments, the magnet had to be routinely rotated between angles of 0, 6, and 90 degrees with respect to the incident electron beam. This was accomplished using a new rotating vacuum seal which permits rotations to be performed in only a few minutes.« less

  14. Antibodies to a conformational epitope on gp41 neutralize HIV...

    Office of Scientific and Technical Information (OSTI)

    Gabriel ; Klein, Florian ; Burton, Dennis R. ; Nussenzweig, Michel C. ; Poignard, Pascal ; Moore, John P. ; Klasse, Per Johan ; Sanders, Rogier W. ; Zwick, Michael B. ; ...

  15. Caribbean-NREL Cooperation | Open Energy Information

    Open Energy Info (EERE)

    internatio Country Anguilla, Antigua and Barbuda, Aruba, Bahamas, Barbados, Cuba, Dominica, Dominican Republic, Grenada, Guadeloupe, Haiti, Jamaica, Martinique, Saint...

  16. Caribbean-GTZ Renewable Energy Program | Open Energy Information

    Open Energy Info (EERE)

    enpraxis95 Country Antigua & Barbuda, Aruba, Bahamas, Barbados, Cayman Islands, Cuba, Dominica, Dominican Republic, Grenada, Guadeloupe, Haiti, Jamaica, Martinique, Puerto...

  17. Costs of Imported Crude Oil by Selected Country

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Baharain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates. c Includes Algeria, Indonesia, Iran, Iraq, Kuwait, Libya, Nigeria, Qatar, Saudi...

  18. untitled

    Gasoline and Diesel Fuel Update (EIA)

    Baharain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates. c Includes Algeria, Indonesia, Iran, Iraq, Kuwait, Libya, Nigeria, Qatar, Saudi...

  19. untitled

    Gasoline and Diesel Fuel Update (EIA)

    Baharain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates. b Includes Algeria, Indonesia, Iran, Iraq, Kuwait, Libya, Nigeria, Qatar, Saudi...

  20. Table 25. Landed Costs of Imported Crude Oil by Selected Country

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Baharain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates. b Includes Algeria, Indonesia, Iran, Iraq, Kuwait, Libya, Nigeria, Qatar, Saudi...

  1. Table Definitions, Sources, and Explanatory Notes

    Gasoline and Diesel Fuel Update (EIA)

    Gulf Includes Bahrain, Iran, Iraq, Kuwait, Qatar, Saudi Arabia, and the United Arab Emirates. Total OPEC Includes Algeria, Indonesia, Iran, Iraq, Kuwait, Libya, Nigeria, Qatar,...

  2. Planning and care mark repair of 14-year old leak in Kuwait Oil Co. LPG tank 95

    SciTech Connect (OSTI)

    Shtayieh, S.

    1983-01-10

    This paper points out that the leak, which had been present for such a long time, completely saturated the perlite insulation with hydrocarbons, thus rendering the entire operation of inspection, repair, and maintenance of the inner tank a hazardous operation. It emphasizes the safety aspects, which were complicated by the saturated perlite as well as by the fact that the tank is situated in the middle of the LPG storage area with LPG tanks on either side. Tank design, making preparations, inspection, and repair are discussed. The fact that the leaking flanges were originally installed damaged, indicated the future need of tighter company quality control of all contractors work.

  3. Smokes from the oil fires following the Gulf War: A review and new perspectives

    SciTech Connect (OSTI)

    Radke, L.F.

    1996-12-31

    Emissions resulting from the oil fires in Kuwait and environmental effects from those emissions are described.

  4. P:\\dtp\\GasPrice\\current\\gp122298new.vp

    Gasoline and Diesel Fuel Update (EIA)

    . . . . . . . . . . . . . . . . . . . . 45 Appendix D. Derivation of Pattern Asymmetry Test Equation . . . . . . . . . . . . . . . . . 55 Tables 3.1 Gasoline Price Levels Move...

  5. Clay Minerals Related To The Hydrothermal Activity Of The Bouillante...

    Open Energy Info (EERE)

    Minerals Related To The Hydrothermal Activity Of The Bouillante Geothermal Field (Guadeloupe) Jump to: navigation, search OpenEI Reference LibraryAdd to library Journal Article:...

  6. Green Solar | Open Energy Information

    Open Energy Info (EERE)

    Solar Jump to: navigation, search Name: Green Solar Place: Paris, France Zip: 45003 Product: Develops and builds PV systems in Guadeloupe and Mauritius. Coordinates: 48.85693,...

  7. Word Pro - S11

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Iraq, Kuwait, Qatar, Saudi Arabia, and the United Arab Emirates. Production from the Neutral Zone between Kuwait and Saudi Arabia is included in "Per- sian Gulf Nations." Web Page:

  8. Energy Transition Initiative: Island Energy Snapshot - Dominica (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2015-03-01

    This profile provides a snapshot of the energy landscape of the Commonwealth of Dominica, an island nation located southeast of Guadeloupe and northwest of Martinique in the Lesser Antilles.

  9. This Week In Petroleum Printer-Friendly Version

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    table below indicates, Persian Gulf producers (Saudi Arabia, Kuwait, the United Arab Emirates, Qatar and Iran) appear to have accounted for 80 percent of the overall cutback over...

  10. Governance for Sustainable Development in the Arab Region | Open...

    Open Energy Info (EERE)

    Resource Type Guidemanual Website http:www.escwa.un.orginform Country Bahrain, Egypt, Iraq, Jordan, Kuwait, Lebanon, Oman, Qatar, Saudi Arabia, Sudan, Syria, United Arab...

  11. Best Practices and Tools for Large-scale Deployment of Renewable...

    Open Energy Info (EERE)

    www.escwa.un.orginformationpublicationsedituploadsdpd-09-TP3.pdf Country: Bahrain, Egypt, Iraq, Jordan, Kuwait, Lebanon, Oman, Qatar, Saudi Arabia, Sudan, Syria, United Arab...

  12. United Nations Economic and Social Commission for Western Asia...

    Open Energy Info (EERE)

    Background Membership "ESCWA comprises 14 Arab countries in Western Asia: Bahrain, Egypt, Iraq, Jordan, Kuwait, Lebanon, Oman, Qatar, Saudi Arabia, Sudan, Syria, United Arab...

  13. National Technology Enterprises Co | Open Energy Information

    Open Energy Info (EERE)

    Technology Enterprises Co Jump to: navigation, search Name: National Technology Enterprises Co Place: Kuwait Sector: Services Product: Services & Support (Clean Energy) (...

  14. untitled

    U.S. Energy Information Administration (EIA) Indexed Site

    of individual company data. a Free on Board. See Glossary. b Includes Baharain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates. c Includes...

  15. Costs of Imported Crude Oil by Selected Country

    U.S. Energy Information Administration (EIA) Indexed Site

    of individual company data. a Free on Board. See Glossary. b Includes Baharain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates. c Includes...

  16. Table 25. Landed Costs of Imported Crude Oil by Selected Country

    U.S. Energy Information Administration (EIA) Indexed Site

    W Withheld to avoid disclosure of individual company data. a Includes Baharain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates. b Includes...

  17. untitled

    U.S. Energy Information Administration (EIA) Indexed Site

    W Withheld to avoid disclosure of individual company data. a Includes Baharain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates. b Includes...

  18. --No Title--

    U.S. Energy Information Administration (EIA) Indexed Site

    No data reported. W Withheld to avoid disclosure of individual company data. 1 Includes Bahrain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates....

  19. --No Title--

    U.S. Energy Information Administration (EIA) Indexed Site

    W Withheld to avoid disclosure of individual company data. 1 Includes Bahrain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates. 2 Includes...

  20. untitled

    U.S. Energy Information Administration (EIA) Indexed Site

    W Withheld to avoid disclosure of individual company data. a Includes Bahrain, Iran, Iraq, Kuwait, Qatar, Saudi Arabia, and United Arab Emirates. b Includes Algeria,...

  1. --No Title--

    U.S. Energy Information Administration (EIA) Indexed Site

    to avoid disclosure of individual company data. 3 Free on Board. See Glossary. 1 Includes Bahrain, Iran, Iraq, Kuwait, Neutral Zone, Qatar, Saudi Arabia, and United Arab Emirates....

  2. LAC Regional Platform Workshop General Information | Open Energy...

    Open Energy Info (EERE)

    Visas Participants Presentations Outcomes Report Links Contact Us General Information (English) General information LEDS GP INCAE English-rev FINAL.pdf Informacion General LEDS GP...

  3. LEDSGP/about/regional-platforms | Open Energy Information

    Open Energy Info (EERE)

    Guiding Structure Regional Platforms LEDS GP regional platforms lead regional peer learning, training, and collaboration; engage technical working groups, the LEDS GP...

  4. TABLE23.CHP:Corel VENTURA

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    3. PAD District II-Imports of Crude Oil and Petroleum Products by Country of Origin, a January 1998 Arab OPEC ...... 6,219 0 0 0 0 0 0 0 0 0 Kuwait ...

  5. Measuring the Costs of U.S. Oil Dependence and the Benefits of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    exporters operating as OPEC." Prof. M. Adelman, MIT, 2004. Algeria Angola Ecuador Iran Iraq Kuwait Libya Nigeria Qatar Saudi Arabia UAE Venezuela 0 20 40 60 80 100 120...

  6. This Week In Petroleum Printer-Friendly Version

    Gasoline and Diesel Fuel Update (EIA)

    from September 2008 production levels. Saudi Arabia, Kuwait, the United Arab Emirates (UAE), and Qatar accounted for about three-fourths of the 2.6 million bbld of actual...

  7. TABLE37.CHP:Corel VENTURA

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Zaire. e Includes Bahrain, Iran, Iraq, Kuwait, Qatar, Saudi Arabia, and United Arab Emirates. (s) Less than 500 barrels per day. Note: Totals may not equal sum of components...

  8. TABLE42.CHP:Corel VENTURA

    Gasoline and Diesel Fuel Update (EIA)

    Zaire. e Includes Bahrain, Iran, Iraq, Kuwait, Qatar, Saudi Arabia, and United Arab Emirates. (s) Less than 500 barrels per day. Note: Totals may not equal sum of components...

  9. Middle East oil and gas

    SciTech Connect (OSTI)

    Not Available

    1984-12-01

    The following subjects are covered in this publication: (1) position of preeminence of the Middle East; (2) history of area's oil operations for Iran, Iraq, Bahrain, Kuwait, Saudi Arabia, neutral zone, Qatar, United Arab Emirates, Oman and Egypt; (3) gas operations of Saudi Arabia, Iran, Kuwait, Qatar, Iraq and United Arab Emirates; (4) changing relationships with producing countries; (5) a new oil pricing environment; (6) refining and other industrial activities; and (7) change and progress. 10 figs., 12 tabs.

  10. Instrument fieldsclose.sdr

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radar Van GP Van BBSS Cart RWP Met Twr ECOR Radiometry Stands PWR Module 25m

  11. Broad and potent HIV-1 neutralization by a human antibody that binds the

    Office of Scientific and Technical Information (OSTI)

    gp41-gp120 interface (Journal Article) | SciTech Connect Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface Citation Details In-Document Search Title: Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface The isolation of human monoclonal antibodies is providing important insights into the specificities that underlie broad neutralization of HIV-1 (reviewed in ref. 1). Here we report a broad and extremely

  12. Geometric phase effects in low-energy dynamics near conical intersections: A study of the multidimensional linear vibronic coupling model

    SciTech Connect (OSTI)

    Joubert-Doriol, Loc; Ryabinkin, Ilya G.; Izmaylov, Artur F.; Chemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6

    2013-12-21

    In molecular systems containing conical intersections (CIs), a nontrivial geometric phase (GP) appears in the nuclear and electronic wave functions in the adiabatic representation. We study GP effects in nuclear dynamics of an N-dimensional linear vibronic coupling (LVC) model. The main impact of GP on low-energy nuclear dynamics is reduction of population transfer between the local minima of the LVC lower energy surface. For the LVC model, we proposed an isometric coordinate transformation that confines non-adiabatic effects within a two-dimensional subsystem interacting with an N ? 2 dimensional environment. Since environmental modes do not couple electronic states, all GP effects originate from nuclear dynamics within the subsystem. We explored when the GP affects nuclear dynamics of the isolated subsystem, and how the subsystem-environment interaction can interfere with GP effects. Comparing quantum dynamics with and without GP allowed us to devise simple rules to determine significance of the GP for nuclear dynamics in this model.

  13. Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells

    SciTech Connect (OSTI)

    Mu, Yang; Li, Liangliang; Zhang, Beibei; Huang, Baicheng; Gao, Jiming; and others

    2015-10-15

    Cell apoptosis is common after infection with porcine reproductive and respiratory syndrome virus (PRRSV). PRRSV GP5 has been reported to induce cell apoptosis. To further understand the role of GP5 in PRRSV induced cell apoptosis, we established Marc-145 cell lines stably expressing full-length GP5, GP5{sup Δ84-96} (aa 84-96 deletion), and GP5{sup Δ97-119} (aa 97-119 deletion). Cell proliferation, cell cycle progression, cell apoptosis and virus replication in these cell lines were evaluated. Neither truncated nor full-length GP5 induced cell apoptosis in Marc-145 cells. However, GP5{sup Δ97-119}, but not full-length or GP5{sup Δ84-96}, induced a cell cycle arrest at the G2/M phase resulting in a reduction in the growth of Marc-145 cells. Additionally, GP5{sup Δ84-96} inhibited the replication of PRRSV in Marc-145 cells through induction of IFN-β. These findings suggest that PRRSV GP5 is not responsible for inducing cell apoptosis in Marc-145 cells under these experimental conditions; however it has other important roles in virus/host cell biology. - Highlights: • Marc-145 cell lines stable expression PRRSV GP5 or truncated GP5 were constructed. • GP5{sup Δ97-119} expression in Marc-145 cell induced cell cycle arrest at G2/M phase. • Expression of GP5 and truncated GP5 could not induce Marc-145 cells apoptosis. • PRRSV replication in Marc-145-GP5{sup Δ84-96} was significantly inhibited.

  14. Oil and gas developments in Middle East in 1985

    SciTech Connect (OSTI)

    Hemer, D.O.; Gohrbandt, K.H.A.

    1986-10-01

    Petroleum production in Middle East countries during 1985 totaled 3,837,580,000 bbl (an average rate of 10,513,917 BOPD), down 2.2% from the revised 1984 total of 3,924,034,000 bbl. Iran, Iraq, Dubai, Oman, and Syria had significant increases; Kuwait, Kuwait-Saudi Arabia Divided Neutral Zone, Saudi Arabia, and Qatar had significant decreases. New fields went on production in Iraq, Abu Dhabi, Oman, and Syria. In North Yemen, the first ever oil production in that country was nearing the start-up stage at year end. 9 figures, 9 tables.

  15. Oil/gas separator for installation at burning wells

    DOE Patents [OSTI]

    Alonso, Carol T.; Bender, Donald A.; Bowman, Barry R.; Burnham, Alan K.; Chesnut, Dwayne A.; Comfort, III, William J.; Guymon, Lloyd G.; Henning, Carl D.; Pedersen, Knud B.; Sefcik, Joseph A.; Smith, Joseph A.; Strauch, Mark S.

    1993-01-01

    An oil/gas separator is disclosed that can be utilized to return the burning wells in Kuwait to production. Advantageously, a crane is used to install the separator at a safe distance from the well. The gas from the well is burned off at the site, and the oil is immediately pumped into Kuwait's oil gathering system. Diverters inside the separator prevent the oil jet coming out of the well from reaching the top vents where the gas is burned. The oil falls back down, and is pumped from an annular oil catcher at the bottom of the separator, or from the concrete cellar surrounding the well.

  16. Oil/gas separator for installation at burning wells

    DOE Patents [OSTI]

    Alonso, C.T.; Bender, D.A.; Bowman, B.R.; Burnham, A.K.; Chesnut, D.A.; Comfort, W.J. III; Guymon, L.G.; Henning, C.D.; Pedersen, K.B.; Sefcik, J.A.; Smith, J.A.; Strauch, M.S.

    1993-03-09

    An oil/gas separator is disclosed that can be utilized to return the burning wells in Kuwait to production. Advantageously, a crane is used to install the separator at a safe distance from the well. The gas from the well is burned off at the site, and the oil is immediately pumped into Kuwait's oil gathering system. Diverters inside the separator prevent the oil jet coming out of the well from reaching the top vents where the gas is burned. The oil falls back down, and is pumped from an annular oil catcher at the bottom of the separator, or from the concrete cellar surrounding the well.

  17. Oil and gas developments in Middle East in 1981

    SciTech Connect (OSTI)

    Hemer, D.O; Mason, J.F.; Hatch, G.C.

    1982-11-01

    Petroleum production in Middle East countries during 1981 totaled 5,741,096,000 bbl, or an average rate of 15,729,030 BOPD, down 14.9% from 1980. Increases were in Oman, Dubai, and Turkey. Significant decreases occurred in Iraq, Iran, Kuwait, Divided Neutral Zone, Qatar, and Abu Dhabi. New discoveries were made in Oman, Saudi Arabia, and Abu Dhabi.

  18. Oral and inhaled corticosteroids: Differences in P-glycoprotein (ABCB1) mediated efflux

    SciTech Connect (OSTI)

    Crowe, Andrew Tan, Ai May

    2012-05-01

    There is concern that P-glycoprotein mediated efflux contributes to steroid resistance. Therefore, this study examined bidirectional corticosteroid transport and induction capabilities for P-glycoprotein (P-gp) to understand which of the systemic and inhaled corticosteroids interacted with P-gp to the greatest extent. Hydrocortisone, prednisolone, prednisone, methylprednisolone, and dexamethasone represented systemically active drugs, while fluticasone propionate, beclomethasone dipropionate, ciclesonide and budesonide represented inhaled corticosteroids. Aldosterone and fludrocortisone represented mineralocorticoids. All drugs were detected using individually optimised HPLC protocols. Transport studies were conducted through Caco-2 monolayers. Hydrocortisone and aldosterone had efflux ratios below 1.5, while prednisone showed a P-gp mediated efflux ratio of only 1.8 compared to its active drug, prednisolone, with an efflux ratio of 4.5. Dexamethasone and beclomethasone had efflux ratios of 2.1 and 3.3 respectively, while this increased to 5.1 for methylprednisolone. Fluticasone showed an efflux ratio of 2.3. Protein expression studies suggested that all of the inhaled corticosteroids were able to induce P-gp expression, from 1.6 to 2 times control levels. Most of the systemic corticosteroids had higher passive permeability (> 20 10{sup ?6} cm/s) compared to the inhaled corticosteroids (> 5 10{sup ?6} cm/s), except for budesonide, with permeability similar to the systemic corticosteroids. Inhaled corticosteroids are not transported by P-gp to the same extent as systemic corticosteroids. However, they are able to induce P-gp production. Thus, inhaled corticosteroids may have greater interactions with other P-gp substrates, but P-gp itself is less likely to influence resistance to the drugs. -- Highlights: ? Inhaled corticosteroids are only weak substrates for P-gp, including budesonide. ? Inhaled corticosteroid potent P-gp inducers especially fluticasone and beclomethasone. ? Systemic corticosteroids are weak P-gp inducers. ? Mineralocorticoids not affected by P-gp mediated efflux.

  19. 2030 District Program and Small Commercial Toolkit

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Districts act as a concierge and GP - pointing partners towards tools for accurate diagnosis and treatment 22 2030 Districts 23 Small Commercial Toolkit: Web Resource Landscape ...

  20. Regional geophysics, Cenozoic tectonics and geologic resources...

    Open Energy Info (EERE)

    and geologic resources of the Basin and Range Province and adjoining regions Author G.P. Eaton Conference Basin and Range Symposium and Great Basin Field Conference; Denver,...

  1. LEDSGP/Transportation Toolkit/Contact Us | Open Energy Information

    Open Energy Info (EERE)

    Contact Us < LEDSGP | Transportation Toolkit Jump to: navigation, search LEDSGP Logo.png Transportation Toolkit Home Tools Training Request Assistance Contacts for the LEDS GP...

  2. --No Title--

    U.S. Energy Information Administration (EIA) Indexed Site

    ... Global Companies Global Petroleum Go-Mart Goodway Refining GP&W Great Island Energy Green Valley Oil Griffith Energy Services Growmark Gulf Oil Gulf Oil Limited Partnership ...

  3. LEDSGP/events | Open Energy Information

    Open Energy Info (EERE)

    https:ceadirseries.adobeconnect.comnov2015ceadirdiscussioneventeventinfo.html?campaign-idLEDS-GP Past Events For information about past events, see past partnership...

  4. Sabien Technology Group Plc | Open Energy Information

    Open Energy Info (EERE)

    Sabien Technology Group Plc Jump to: navigation, search Name: Sabien Technology Group Plc Place: Manchester, England, United Kingdom Zip: SK8 3GP Product: Sabien builds and...

  5. EIA-782C Exclusionary list instructions

    Gasoline and Diesel Fuel Update (EIA)

    ... & Industrial Supply GP&W (Center Oil) Ergon Refining Great Island Energy (Gulf Oil) Ergon West Virginia Green Valley Oil Esso Eastern, Guam Branch Griffith Energy Services Excel ...

  6. The Gulf War and the environment

    SciTech Connect (OSTI)

    El-Baz, F. (ed.) (Boston Univ., MA (United States). Center for Remote Sensing); Makharita, R.M. (ed.) (World Bank, Washington, DC (United States))

    1994-01-01

    The Gulf War inflicted dramatic environmental damage upon the fragile desert and shore environments of Kuwait and northeastern Saudi Arabia. Coastal and marine environments experienced oil spills of more than 8 million barrels, which killed wildlife and damaged the fishing industry. In inland Kuwait, hundreds of oil lakes are scattered across the desert surface: these lakes emit noxious gases, drown insects and birds, and may seep to pollute groundwater. Exploding and burning oil wells released soot particles, oil droplets, and noxious chemicals into the atmosphere, spreading air pollution, acid rain, and respiratory problems. Military diggings, constructions, and vehicles have destroyed much of the desert pavement, resulting in increased dust storms and large, moving dunes.

  7. TABLE29.CHP:Corel VENTURA

    Gasoline and Diesel Fuel Update (EIA)

    9. Net Imports of Crude Oil and Petroleum Products into the United States by Country, (Thousand Barrels per Day) January 1998 Arab OPEC .................................. 1,726 37 20 0 (s) 41 -3 (s) 296 391 2,116 Algeria ...................................... 0 37 0 0 0 27 0 0 252 316 316 Iraq ........................................... 36 0 0 0 0 0 0 0 0 0 36 Kuwait ....................................... 252 0 0 0 0 0 0 (s) (s) (s) 252 Qatar ........................................ 0 0 0 0 0 0

  8. JPRS report: Arms control, [November 3, 1989

    SciTech Connect (OSTI)

    1989-11-03

    This report contains translations/transcriptions of articles and/or broadcasts on arms control. Titles include: 5-Power Defense Arrangement Exercise Opens; Paper Sees Growing Danger of Nuclear War; 3rd Round of Conventional Forces Talk; General Notes Inadequate Discipline in Army; Arianespace Assures Liquid Fuel Technology; King Hussain Warns of Nuclear Threat in Region; Kuwait Defense Minister on Weapons Development, GCC; Commentary on Change in NATO Count of Combat Aircraft; and others.

  9. East Coast (PADD 1) Imports from All Countries

    U.S. Energy Information Administration (EIA) Indexed Site

    Import Area: East Coast (PADD 1) Midwest (PADD 2) Gulf Coast (PADD 3) Rocky Mountain (PADD 4) West Coast (PADD 5) Period/Unit: Monthly-Thousand Barrels Monthly-Thousand Barrels per Day Annual-Thousand Barrels Annual-Thousand Barrels per Day Country: All Countries Persian Gulf OPEC Algeria Angola Ecuador Indonesia Iraq Kuwait Libya Nigeria Qatar Saudi Arabia United Arab Emirates Venezuela Non OPEC Albania Argentina Aruba Australia Austria Azerbaijan Bahamas Bahrain Barbados Belarus Belgium Bosnia

  10. NREL: Geothermal Technologies - News Release Archives

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5 November 17, 2015 New Geothermal Lab Manager Joins NREL Henry (Bud) Johnston joined NREL on October 12 as the new Laboratory Program Manager for the Geothermal Technologies Program. June 10, 2015 Geothermal Energy Association Honors Two NRELians with Top Recognition Dan Getman and Jordan Macknick were recognized by the Geothermal Energy Association (GEA) during its National Geothermal Summit on June 3, 2015, in Reno, Nevada. June 8, 2015 Kuwait Visitors Interested in NREL Solar and Geothermal

  11. ORISE: Radiation Emergency Training for Iraq, South Africa and Morocco

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    International Training REAC/TS Provides International Radiation Emergency Medical Response Training for Emergency Responders In support of the National Nuclear Security Administration's international approach to nuclear and radiological incident response, REAC/TS staff provide training to physicians, nurses and emergency responders in multiple countries each year. REAC/TS has conducted radiation emergency medical response training in Iraq, Kuwait, Morocco, Singapore, South Africa, and Thailand.

  12. Middle East

    SciTech Connect (OSTI)

    Hemer, D.O.; Mason, J.F.; Hatch, G.C.

    1981-10-01

    Petroleum production in Middle East countries during 1980 totaled 6,747,719,000 bbl or an average rate of 18,436,390,000 bbl/d, down 13.9% from 1979. Increases were in Saudi Arabia and Syria. Significant decreases occurred in Iraq, Iran, Kuwait, and Turkey. New discoveries were made in Abu Dhabi, Iran, Saudi Arabia, Sharjah, and Oman. New areas were explored in Bahrain, Oman, Syria, and Yemen. 9 figures, 16 tables.

  13. Middle East: Output expansions boost drilling

    SciTech Connect (OSTI)

    1996-08-01

    Iraqi exports may return to the market in limited fashion, but none of the region`s producers seems particularly concerned. They believe that global oil demand is rising fast enough to justify their additions to productive capacity. The paper discusses exploration, drilling and development, and production in Saudi Arabia, Kuwait, the Neutral Zone, Abu Dhabi, Dubai, Oman, Iran, Iraq, Yemen, Qatar, Syria, Turkey, and Sharjah. The paper also briefly mentions activities in Bahrain, Israel, Jordan, and Ras al Khaimah.

  14. Oil and gas developments in Middle East in 1982

    SciTech Connect (OSTI)

    Hemer, D.O.; Hatch, G.C.

    1983-10-01

    Petroleum production in Middle East countries during 1982 totaled 4,499,464,000 bbl (an average rate of 12,162,915 BOPD), down 21.5% from 1981. Increases were in Iraq, Iran, and Oman. Significant decreases occurred in Kuwait, Divided Neutral Zone, Saudi Arabia, Qatar, and Abu Dhabi. New discoveries were reported in Oman, Syria, Abu Dhabi, Dubai, Iran, and Saudi Arabia.

  15. Somebody better find some rigs

    SciTech Connect (OSTI)

    1997-08-01

    The paper discusses the outlook for the gas and oil industries of the Middle East. Field development projects abound, as the larger exporting nations pursue ambitious policies of production expansion. However, their plans may be hampered by the growing worldwide shortage of rigs. Separate evaluations are given for Saudi Arabia, Kuwait, Neutral Zone, Abu Dhabi, Iran, Iraq, Qatar, Yemen, Syria, Dubai, Turkey, Sharjah, and briefly for Bahrain, Israel, Jordan, UAE-Ajman, and UAE-Ras al-Khaimah.

  16. Concentrating Solar Power Projects by Country | Concentrating Solar Power |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NREL Country In this section, you can select a country from the map or the following list of countries. You can then select a specific concentrating solar power (CSP) project and review a profile covering project basics, participating organizations, and power plant configuration data for the solar field, power block, and thermal energy storage. Javascript must be enabled to view Flash movie Algeria Australia Canada Chile China Egypt France Germany India Israel Italy Kuwait Mexico Morocco

  17. A replication-deficient rabies virus vaccine expressing Ebola virus glycoprotein is highly attenuated for neurovirulence

    SciTech Connect (OSTI)

    Papaneri, Amy B.; Wirblich, Christoph; Cann, Jennifer A.; Cooper, Kurt; Jahrling, Peter B.; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick MD, 21702 ; Schnell, Matthias J.; Blaney, Joseph E.

    2012-12-05

    We are developing inactivated and live-attenuated rabies virus (RABV) vaccines expressing Ebola virus (EBOV) glycoprotein for use in humans and endangered wildlife, respectively. Here, we further characterize the pathogenesis of the live-attenuated RABV/EBOV vaccine candidates in mice in an effort to define their growth properties and potential for safety. RABV vaccines expressing GP (RV-GP) or a replication-deficient derivative with a deletion of the RABV G gene (RV{Delta}G-GP) are both avirulent after intracerebral inoculation of adult mice. Furthermore, RV{Delta}G-GP is completely avirulent upon intracerebral inoculation of suckling mice unlike parental RABV vaccine or RV-GP. Analysis of RV{Delta}G-GP in the brain by quantitative PCR, determination of virus titer, and immunohistochemistry indicated greatly restricted virus replication. In summary, our findings indicate that RV-GP retains the attenuation phenotype of the live-attenuated RABV vaccine, and RV{Delta}G-GP would appear to be an even safer alternative for use in wildlife or consideration for human use.

  18. Asymptotic geometric phase and purity for phase qubit dispersively coupled to lossy LC circuit

    SciTech Connect (OSTI)

    Mohamed, A.-B.A.; Obada, A.-S.F.

    2011-09-15

    Analytical descriptions of the geometric phases (GPs) for the total system and subsystems are studied for a current biased Josephson phase qubit strongly coupled to a lossy LC circuit in the dispersive limit. It is found that, the GP and purity depend on the damping parameter which leads to the phenomenon of GP death. Coherence parameter delays the phenomenon of a regular sequence of deaths and births of the GP. The asymptotic behavior of the GP and the purity for the qubit-LC resonator state closely follow that for the qubit state, but however, for the LC circuit these asymptotic values are equal to zero. - Highlights: > The model of a current biased Josephson phase qubit, strongly coupled to loss LC circuit, is considered. > Analytical descriptions of the geometric phase (GP) of this model, in the dispersive limit, are studied. > The GP and purity depend on the dissipation which leads to the GP death phenomenon. > Coherence parameter delays the phenomenon of a regular sequence of deaths and births of the GP.

  19. Measurement of Muon Capture on the Proton to 1% Precision and Determination

    Office of Scientific and Technical Information (OSTI)

    of the Pseudoscalar Coupling gP (Journal Article) | SciTech Connect Muon Capture on the Proton to 1% Precision and Determination of the Pseudoscalar Coupling gP Citation Details In-Document Search Title: Measurement of Muon Capture on the Proton to 1% Precision and Determination of the Pseudoscalar Coupling gP Authors: Andreev, V. A. ; Banks, T. I. ; Carey, R. M. ; Case, T. A. ; Clayton, S. M. ; Crowe, K. M. ; Deutsch, J. ; Egger, J. ; Freedman, S. J. ; Ganzha, V. A. ; Gorringe, T. ; Gray,

  20. 2030 District Program and Small Commercial Toolkit

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Districts act as a concierge and GP - pointing partners towards tools for accurate diagnosis and treatment 22 2030 Districts 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 ...

  1. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    These compounds bind inside the P-gp cavity, preventing other substances from entering. Chang and Aller were able to obtain the structures of two of Zhang's compounds inside...

  2. Microsoft Word - Turbine Manufactures MOU FINAL_5-31-08_.doc

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Vice President-Renewables General Electric Energy James G.P. Dehlsen Chairman and CEO Clipper Turbine Works, Inc. Toine van Megan CEO Suzlon Energy Julius Steiner CEO Gamesa USA

  3. Danionics Asia Ltd | Open Energy Information

    Open Energy Info (EERE)

    Place: N.T., Hong Kong, Hong Kong Product: JV between Danionics AS, Denmark, and GP Batteries International Ltd., Hong Kong. References: Danionics Asia Ltd1 This article is a...

  4. April 2013 Most Viewed Documents for Energy Storage, Conversion...

    Office of Scientific and Technical Information (OSTI)

    and the impact on PV system design Stevens, J.W.; Corey, G.P. (1996) 173 > Energy Saving Potentials and Air Quality Benefits of Urban HeatIslandMitigation Akbari, Hashem ...

  5. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Picard, J. (7) Schmidt, H. (7) Capitani, G.P. (6) Miller, J. (6) Vastel, M. (6) Save ... We find that the Longitudinal Response Function for these nuclei is quenched and that the ...

  6. ALSNews Vol. 298

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help...

  7. Property List for RO Code '37', EDI

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    POWERED COU ALLEGHENY CLARK GPX25E GPX230E0579231 17,499.00 902 000 C5583 FORKLIFT PROPANE CATERPILLAR GP20 5AM08330 16,875.00 6 None 0156551 FORKLIFT, 3000 LB YALE L314...

  8. S M Stoller Pinellas Environmental Restoration Project - Young...

    Office of Legacy Management (LM)

    ... Wet Chemistry By Method EPA 410.1 Matrix: AQ Batch ID: GP7023 Samples F35460-1DUP, F35460-1MSD were used as the QC samples for Chemical Oxygen Demand, Chemical Oxygen Demand. All ...

  9. Structure of the Ebola virus glycoprotein bound to an antibody...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a heavily glycosylated, unstructured mucin-like domain. GP was known to be cleaved by cathepsin proteases as an essential step in entry, but the precise site or role of cleavage...

  10. Structure of P-Glycoprotein Reveals a Molecular Basis for Poly...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding figure 1 Figure 1. Structure of P-gp. Many forms of cancer fail to respond to chemotherapy by ...

  11. Structure of P-Glycoprotein Reveals a Molecular Basis for Poly...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for Poly-Specific Drug Binding figure 1 Figure 1. Structure of P-gp. Many forms of cancer fail to respond to chemotherapy by acquiring multidrug resistance (MDR), to which has...

  12. Application to Export Electric Energy OE Docket No. EA-363-A...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    OE Docket No. EA-363-A Noble Americas Gas & Power Corporation Application from NAG&P to export electric energy to Mexico. PDF icon EA-363-A Noble Americas G&P (MX).pdf More...

  13. Garland Power and Light Solar Rebate Program

    Broader source: Energy.gov [DOE]

    A utility bill credit is available to encourage Garland Power and Light (GP&L) customers to install solar photovoltaic panels that meet the minimum requirements of the program. Please check the...

  14. ALSNews Vol. 298

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to...

  15. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to...

  16. BooNE: Booster Neutrino Experiment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Results from the MiniBooNE Experiment OpenOffice S. Brice Neutrino08 May 25-31, 2008 Christchurch, New Zealand MiniBooNE Oscillation Serches PowerPoint G.P. Zeller Low Energy ...

  17. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help...

  18. Flexible Pillared Graphene-Paper Electrodes for High-Performance Electrochemical Supercapacitors

    SciTech Connect (OSTI)

    Wang, Gongkai; Sun, Xiang; Lu, Fengyuan; Sun, Hongtao; Yu, Mingpeng; Jiang, Weilin; Liu, Changsheng; Lian, Jie

    2012-02-09

    Flexible graphene paper (GP) pillared by carbon black (CB) nanoparticles using a simple vacuum filtration method is developed as a high-performance electrode material for supercapacitors. Through the introduction of CB nanoparticles as spacers, the self-restacking of graphene sheets during the filtration process is mitigated to a great extent. The pillared GP-based supercapacitors exhibit excellent electrochemical performances and cyclic stabilities compared with GP without the addition of CB nanoparticles. At a scan rate of 10 mV s?1, the specific capacitance of the pillared GP is 138 F g^?1 and 83.2 F g^?1 with negligible 3.85% and 4.35% capacitance degradation after 2000 cycles in aqueous and organic electrolytes, respectively. At an extremely fast scan rate of 500 mV s ^?1, the specific capacitance can reach 80 F g^?1 in aqueous electrolyte. No binder is needed for assembling the supercapacitor cells and the pillared GP itself may serve as a current collector due to its intrinsic high electrical conductivity. The pillared GP has great potential in the development of promising flexible and ultralight-weight supercapacitors for electrochemical energy storage.

  19. TABLE21.CHP:Corel VENTURA

    Gasoline and Diesel Fuel Update (EIA)

    1. Imports of Crude Oil and Petroleum Products into the United States by Country of Origin, a January 1998 Arab OPEC .................................. 53,500 1,139 2,258 115 625 0 0 1,267 0 0 Algeria ...................................... 0 1,139 1,174 115 0 0 0 824 0 0 Iraq ........................................... 1,110 0 0 0 0 0 0 0 0 0 Kuwait ....................................... 7,822 0 0 0 0 0 0 0 0 0 Saudi Arabia ............................. 44,568 0 1,084 0 625 0 0 443 0 0 Other

  20. TABLE23.CHP:Corel VENTURA

    Gasoline and Diesel Fuel Update (EIA)

    3. PAD District II-Imports of Crude Oil and Petroleum Products by Country of Origin, a January 1998 Arab OPEC ................................... 6,219 0 0 0 0 0 0 0 0 0 Kuwait ....................................... 1,253 0 0 0 0 0 0 0 0 0 Saudi Arabia ............................. 4,966 0 0 0 0 0 0 0 0 0 Other OPEC .................................. 4,136 0 0 0 0 0 0 0 0 0 Nigeria ...................................... 540 0 0 0 0 0 0 0 0 0 Venezuela ................................. 3,596 0 0

  1. TABLE24.CHP:Corel VENTURA

    Gasoline and Diesel Fuel Update (EIA)

    4. PAD District III-Imports of Crude Oil and Petroleum Products by Country of Origin, a January 1998 Arab OPEC ................................... 38,701 294 2,258 0 0 0 0 443 0 0 Algeria ....................................... 0 294 1,174 0 0 0 0 0 0 0 Kuwait ........................................ 5,270 0 0 0 0 0 0 0 0 0 Saudi Arabia .............................. 33,431 0 1,084 0 0 0 0 443 0 0 Other OPEC .................................. 41,555 0 1,652 0 0 0 0 0 0 0 Nigeria

  2. TABLE25A.CHP:Corel VENTURA

    Gasoline and Diesel Fuel Update (EIA)

    PAD District V PAD District IV January 1998 Non OPEC .................................... 3,980 424 0 0 13 0 140 0 0 0 Canada ..................................... 3,980 424 0 0 13 0 140 0 0 0 Total .............................................. 3,980 424 0 0 13 0 140 0 0 0 Arab OPEC .................................. 2,409 0 0 0 0 0 0 0 0 0 Iraq ........................................... 1,110 0 0 0 0 0 0 0 0 0 Kuwait ....................................... 1,299 0 0 0 0 0 0 0 0 0 Saudi Arabia

  3. Oil and gas developments in Middle East in 1984

    SciTech Connect (OSTI)

    Hemer, D.O.; Lyle, J.H.

    1985-10-01

    Petroleum production in Middle East countries during 1984 totaled 4,088,853,000 bbl (an average rate of 11,144,407 BOPD), down less than 1.0% from the revised total of 4,112,116,000 bbl produced in 1983. Iraq, Kuwait, Qatar, and Oman had significant increases; Iran and Dubai had significant decreases. Jordan produced oil, although a minor amount, for the first time ever, and new production facilities were in the planning stage in Syria, North Yemen, and Oman, which will bring new fields on stream when completed.

  4. Oil and gas developments in Middle East in 1986

    SciTech Connect (OSTI)

    Hemer, D.O.; Gohrbandt, K.H.A.

    1987-10-01

    Petroleum production in Middle East countries during 1986 totaled 4,493,973,000 bbl (an average rate of 12,312,254 BOPD), up 22.3% from the revised 1985 total of 3,673,729,000 bbl. Iraq, Kuwait, Saudi Arabia, Abu Dhabi, and Oman had significant increased; Iran was the only Middle East country with a significant decrease. New fields went on production in Oman and Yemen Arab Republic, and significant discoveries were reported in Iraq, Yemen Arab Republic, Oman, and Syria. However, exploration was generally down in most countries. Exploration and production operations continued to be affected by war in Iraq and Iran. 8 figures, 7 tables.

  5. Oil and gas developments in Middle East in 1984

    SciTech Connect (OSTI)

    Hemer, D.O.; Lyle, J.H.

    1985-10-01

    Petroleum production in Middle East countries during 1984 totaled 4,088,853,000 bbl (an average rate of 11,144,407 BOPD), down less than 1.0% from the revised total of 4,112,116,000 bbl produced in 1983. Iraq, Kuwait, Qatar, and Oman had significant increases; Iran and Dubai had significant decreases. Jordan produced oil, although a minor amount, for the first time ever, and new production facilities were in the planning stage in Syria, North Yemen, and Oman, which will bring new fields on stream when completed. 4 figures, 9 tables.

  6. When do we need to account for the geometric phase in excited state dynamics?

    SciTech Connect (OSTI)

    Ryabinkin, Ilya G.; Joubert-Doriol, Loc; Izmaylov, Artur F.

    2014-06-07

    We investigate the role of the geometric phase (GP) in an internal conversion process when the system changes its electronic state by passing through a conical intersection (CI). Local analysis of a two-dimensional linear vibronic coupling (LVC) model Hamiltonian near the CI shows that the role of the GP is twofold. First, it compensates for a repulsion created by the so-called diagonal BornOppenheimer correction. Second, the GP enhances the non-adiabatic transition probability for a wave-packet part that experiences a central collision with the CI. To assess the significance of both GP contributions we propose two indicators that can be computed from parameters of electronic surfaces and initial conditions. To generalize our analysis to N-dimensional systems we introduce a reduction of a general N-dimensional LVC model to an effective 2D LVC model using a mode transformation that preserves short-time dynamics of the original N-dimensional model. Using examples of the bis(methylene) adamantyl and butatriene cations, and the pyrazine molecule we have demonstrated that their effective 2D models reproduce the short-time dynamics of the corresponding full dimensional models, and the introduced indicators are very reliable in assessing GP effects.

  7. Analysis of geometric phase effects in the quantum-classical Liouville formalism

    SciTech Connect (OSTI)

    Ryabinkin, Ilya G.; Izmaylov, Artur F.; Chemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6 ; Hsieh, Chang-Yu; Kapral, Raymond

    2014-02-28

    We analyze two approaches to the quantum-classical Liouville (QCL) formalism that differ in the order of two operations: Wigner transformation and projection onto adiabatic electronic states. The analysis is carried out on a two-dimensional linear vibronic model where geometric phase (GP) effects arising from a conical intersection profoundly affect nuclear dynamics. We find that the Wigner-then-Adiabatic (WA) QCL approach captures GP effects, whereas the Adiabatic-then-Wigner (AW) QCL approach does not. Moreover, the Wigner transform in AW-QCL leads to an ill-defined Fourier transform of double-valued functions. The double-valued character of these functions stems from the nontrivial GP of adiabatic electronic states in the presence of a conical intersection. In contrast, WA-QCL avoids this issue by starting with the Wigner transform of single-valued quantities of the full problem. As a consequence, GP effects in WA-QCL can be associated with a dynamical term in the corresponding equation of motion. Since the WA-QCL approach uses solely the adiabatic potentials and non-adiabatic derivative couplings as an input, our results indicate that WA-QCL can capture GP effects in two-state crossing problems using first-principles electronic structure calculations without prior diabatization or introduction of explicit phase factors.

  8. Geometric phase and entanglement of Raman photon pairs in the presence of photonic band gap

    SciTech Connect (OSTI)

    Berrada, K.; Ooi, C. H. Raymond; Abdel-Khalek, S.

    2015-03-28

    Robustness of the geometric phase (GP) with respect to different noise effects is a basic condition for an effective quantum computation. Here, we propose a useful quantum system with real physical parameters by studying the GP of a pair of Stokes and anti-Stokes photons, involving Raman emission processes with and without photonic band gap (PBG) effect. We show that the properties of GP are very sensitive to the change of the Rabi frequency and time, exhibiting collapse phenomenon as the time becomes significantly large. The system allows us to obtain a state which remains with zero GP for longer times. This result plays a significant role to enhance the stabilization and control of the system dynamics. Finally, we investigate the nonlocal correlation (entanglement) between the pair photons by taking into account the effect of different parameters. An interesting correlation between the GP and entanglement is observed showing that the PBG stabilizes the fluctuations in the system and makes the entanglement more robust against the change of time and frequency.

  9. A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

    SciTech Connect (OSTI)

    Pejchal, Robert; Doores, Katie J.; Walker, Laura M.; Khayat, Reza; Huang, Po-Ssu; Wang, Sheng-Kai; Stanfield, Robyn L.; Julien, Jean-Philippe; Ramos, Alejandra; Crispin, Max; Depetris, Rafael; Katpally, Umesh; Marozsan, Andre; Cupo, Albert; Maloveste, Sebastien; Liu, Yan; McBride, Ryan; Ito, Yukishige; Sanders, Rogier W.; Ogohara, Cassandra; Paulson, James C.; Feizi, Ten; Scanlan, Christopher N.; Wong, Chi-Huey; Moore, John P.; Olson, William C.; Ward, Andrew B.; Poignard, Pascal; Schief, William R.; Burton, Dennis R.; Wilson, Ian A.

    2015-10-15

    The HIV envelope (Env) protein gp120 is protected from antibody recognition by a dense glycan shield. However, several of the recently identified PGT broadly neutralizing antibodies appear to interact directly with the HIV glycan coat. Crystal structures of antigen-binding fragments (Fabs) PGT 127 and 128 with Man{sub 9} at 1.65 and 1.29 angstrom resolution, respectively, and glycan binding data delineate a specific high mannose-binding site. Fab PGT 128 complexed with a fully glycosylated gp120 outer domain at 3.25 angstroms reveals that the antibody penetrates the glycan shield and recognizes two conserved glycans as well as a short {beta}-strand segment of the gp120 V3 loop, accounting for its high binding affinity and broad specificify. Furthermore, our data suggest that the high neutralization potency of PGT 127 and 128 immunoglobulin Gs may be mediated by cross-linking Env trimers on the viral surface.

  10. Table 5.20 Value of Crude Oil Imports From Selected Countries, 1973-2011 (Thousand Dollars )

    U.S. Energy Information Administration (EIA) Indexed Site

    0 Value of Crude Oil Imports From Selected Countries, 1973-2011 (Thousand Dollars 1) Year Persian Gulf 3 Selected OPEC 2 Countries Selected Non-OPEC 2 Countries Total 5 Kuwait Nigeria Saudi Arabia Venezuela Total OPEC 4 Canada Colombia Mexico Norway United Kingdom Total Non-OPEC 4 1973 1,729,733 W 1,486,278 904,979 753,195 5,237,483 1,947,422 W – 0 0 2,351,931 7,589,414 1974 4,419,410 W 3,347,351 1,858,788 1,309,916 11,581,515 3,314,999 0 W – 0 4,054,475 15,635,990 1975 5,169,811 W 3,457,766

  11. Net Imports of Total Crude Oil and Products into the U.S. by Country

    U.S. Energy Information Administration (EIA) Indexed Site

    2010 2011 2012 2013 2014 2015 View History Total All Countries 9,441 8,450 7,393 6,237 5,065 4,651 1973-2015 Persian Gulf 1,705 1,842 2,149 1,988 1,861 1,496 1993-2015 OPEC* 4,787 4,429 4,093 3,483 2,996 2,652 1993-2015 Algeria 510 355 241 108 109 105 1993-2015 Angola 393 346 233 215 154 136 1993-2015 Ecuador 135 147 117 153 116 104 1993-2015 Indonesia 37 20 6 23 24 37 1993-2015 Iran 0 0 1993-2014 Iraq 415 459 476 341 369 229 1996-2015 Kuwait 197 191 305 328 311 206 1993-2015 Libya 70 15 60 58 5

  12. New constraints in absorptive capacity and the optimum rate of petroleum output

    SciTech Connect (OSTI)

    El Mallakh, R

    1980-01-01

    Economic policy in four oil-producing countries is analyzed within a framework that combines a qualitative assessment of the policy-making process with an empirical formulation based on historical and current trends in these countries. The concept of absorptive capacity is used to analyze the optimum rates of petroleum production in Iran, Iraq, Saudi Arabia, and Kuwait. A control solution with an econometric model is developed which is then modified for alternative development strategies based on analysis of factors influencing production decisions. The study shows the consistencies and inconsistencies between the goals of economic growth, oil production, and exports, and the constraints on economic development. Simulation experiments incorporated a number of the constraints on absorptive capacity. Impact of other constraints such as income distribution and political stability is considered qualitatively. (DLC)

  13. East Coast (PADD 1) Distillate Fuel Oil Imports

    Gasoline and Diesel Fuel Update (EIA)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 942 1,260 1,471 1,990 2000's 2,114 1,896 1,914 1,969 2,258 2,132 2,118 1,955 1,695 1,237 2010's 1,471 2,114 2,970 2,608 3,801 4,282

    Sep-15 Oct-15 Nov-15 Dec-15 Jan-16 Feb-16 View History All Countries 76 92 133 130 137 187 1981-2016 Persian Gulf 23 1995-2016 OPEC* 10 23 1993-2016 Algeria 1994-2010 Angola 1995-2003 Indonesia 1995-2008 Kuwait 1995-2012 Libya 2013-2013 Nigeria 10 1993-2015 Qatar 23 1995-2016

  14. Nevada Dry Natural Gas Production (Million Cubic Feet)

    Gasoline and Diesel Fuel Update (EIA)

    2010 2011 2012 2013 2014 2015 View History Total All Countries 9,441 8,450 7,393 6,237 5,065 4,651 1973-2015 Persian Gulf 1,705 1,842 2,149 1,988 1,861 1,496 1993-2015 OPEC* 4,787 4,429 4,093 3,483 2,996 2,652 1993-2015 Algeria 510 355 241 108 109 105 1993-2015 Angola 393 346 233 215 154 136 1993-2015 Ecuador 135 147 117 153 116 104 1993-2015 Indonesia 37 20 6 23 24 37 1993-2015 Iran 0 0 1993-2014 Iraq 415 459 476 341 369 229 1996-2015 Kuwait 197 191 305 328 311 206 1993-2015 Libya 70 15 60 58 5

  15. Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge

    SciTech Connect (OSTI)

    Bukreyev, Alexander Marzi, Andrea; Feldmann, Friederike; Zhang Liqun; Dorward, David W.; Pickles, Raymond J.; Feldmann, Heinz; Collins, Peter L.

    2009-01-20

    We generated a new live-attenuated vaccine against Ebola virus (EBOV) based on a chimeric virus HPIV3/{delta}F-HN/EboGP that contains the EBOV glycoprotein (GP) as the sole transmembrane envelope protein combined with the internal proteins of human parainfluenza virus type 3 (HPIV3). Electron microscopy analysis of the virus particles showed that they have an envelope and surface spikes resembling those of EBOV and a particle size and shape resembling those of HPIV3. When HPIV3/{delta}F-HN/EboGP was inoculated via apical surface of an in vitro model of human ciliated airway epithelium, the virus was released from the apical surface; when applied to basolateral surface, the virus infected basolateral cells but did not spread through the tissue. Following intranasal (IN) inoculation of guinea pigs, scattered infected cells were detected in the lungs by immunohistochemistry, but infectious HPIV3/{delta}F-HN/EboGP could not be recovered from the lungs, blood, or other tissues. Despite the attenuation, the virus was highly immunogenic, and a single IN dose completely protected the animals against a highly lethal intraperitoneal challenge of guinea pig-adapted EBOV.

  16. Geometric phase of a qubit driven by a phase noise laser under non-Markovian dynamics

    SciTech Connect (OSTI)

    Berrada, K.

    2014-01-15

    Robustness of the geometric phase (GP) with respect to the environmental effects is a basic condition for an effective quantum computation. Here, we study quantitatively the GP of a two-level atom system driven by a phase noise laser under non-Markovian dynamics in terms of different parameters involved in the whole system. We find that with the change of the damping coupling, the GP is very sensitive to its properties exhibiting long collapse and revival phenomena, which play a significant role in enhancing the stabilization and control of the system dynamics. Moreover, we show that the GP can be considered as a tool for testing and characterizing the nature of the qubitenvironment coupling. Due to the significance of how a system is quantum correlated with its environment in the construction of a scalable quantum computer, the entanglement dynamics between the qubit with its environment under external classical noise is evaluated and investigated during the time evolution. -- Highlights: Geometric phase under noise phase laser. Dynamics of the geometric phase under non-Markovian dynamics in the presence of classical noise. Solution of master equation of the system in terms atomic inversion. Nonlocal correlation between the system and its environment under non-Markovianity.

  17. L

    Office of Legacy Management (LM)

    * ; ' -f ..". ., ii f J nulm & . - 8. Jb w* Icarprm. OlJr -GP oP--*- 5 ;fwle o-*-w 3 3 1953, &mkm&Yypr(pt 8 -lfac -- OF zmmsm tFsmm L m&mhjb ,. *AATEPAU < @YJ I AMlwalmr...

  18. Adhesion and Wetting of Soft Nanoparticles on Textured Surfaces: Transition between Wenzel and Cassie-Baxter States

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cao, Zhen; Stevens, Mark J.; Carrillo, Jan-Michael Y.; Dobrynin, Andrey V.

    2015-01-16

    We use a combination of the molecular dynamics simulations and scaling analysis to study interactions between gel-like nanoparticles and substrates covered with rectangular shape posts. Our simulations have shown that nanoparticle in contact with substrate undergo first order transition between Wenzel and Cassie-Baxter state which location depends on nanoparticle shear modulus, the strength of nanoparticle-substrate interactions, height of the substrate posts and nanoparticle size, Rp. There is a range of system parameters where these two states coexist such that the average indentation δ produced by substrate posts changes monotonically with nanoparticle shear modulus, Gp. We have developed a scaling modelmore » that describes deformation of nanoparticle in contact with patterned substrate. In the framework of this model the effect of the patterned substrate can be taken into account by introducing an effective work of adhesion, Weff, which describes the first order transition between Wenzel and Cassie-Baxter states. There are two different shape deformation regimes for nanoparticles with shear modulus Gp and surface tension γp. Shape of small nanoparticles with size Rp < γp 3/2Gp-1 Weff-1/2 is controlled by capillary forces while deformation of large nanoparticles, Rp > γp 3/2Gp-1 Weff-1/2« less

  19. Structure of a bacterial virus DNA-injection protein complex reveals a decameric assembly with a constricted molecular channel

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zhao, Haiyan; Speir, Jeffrey A.; Matsui, Tsutomu; Lin, Zihan; Liang, Lingfei; Lynn, Anna Y.; Varnado, Brittany; Weiss, Thomas M.; Tang, Liang; Schuch, Raymond

    2016-02-16

    The multi-layered cell envelope structure of Gram-negative bacteria represents significant physical and chemical barriers for short-tailed phages to inject phage DNA into the host cytoplasm. Here we show that a DNA-injection protein of bacteriophage Sf6, gp12, forms a 465-kDa, decameric assembly in vitro. The electron microscopic structure of the gp12 assembly shows a ~150-Å, mushroom-like architecture consisting of a crown domain and a tube-like domain, which embraces a 25-Å-wide channel that could precisely accommodate dsDNA. The constricted channel suggests that gp12 mediates rapid, uni-directional injection of phage DNA into host cells by providing a molecular conduit for DNA translocation. Themore » assembly exhibits a 10-fold symmetry, which may be a common feature among DNA-injection proteins of P22-like phages and may suggest a symmetry mismatch with respect to the 6-fold symmetric phage tail. As a result, the gp12 monomer is highly flexible in solution, supporting a mechanism for translocation of the protein through the conduit of the phage tail toward the host cell envelope, where it assembles into a DNA-injection device.« less

  20. DT. A, E. ?3ewwe

    Office of Legacy Management (LM)

    1, ohi0 tuqeotl j&gp&s 3y c&jTD,Ni.bkL4 SPAI& WR i&i. 2' . lkwr in-0 imulsrr Xt ia requested that lO-potmi simpltlv of raw and roah;tci: c%uxthrmos rhrls So fomwded to...

  1. Comparisons between tokamak fueling of gas puffing and supersonic molecular beam injection in 2D simulations

    SciTech Connect (OSTI)

    Zhou, Y. L.; Wang, Z. H.; Xu, X. Q.; Li, H. D.; Feng, H.; Sun, W. G.

    2015-01-15

    Plasma fueling with high efficiency and deep injection is very important to enable fusion power performance requirements. It is a powerful and efficient way to study neutral transport dynamics and find methods of improving the fueling performance by doing large scale simulations. Two basic fueling methods, gas puffing (GP) and supersonic molecular beam injection (SMBI), are simulated and compared in realistic divertor geometry of the HL-2A tokamak with a newly developed module, named trans-neut, within the framework of BOUT++ boundary plasma turbulence code [Z. H. Wang et al., Nucl. Fusion 54, 043019 (2014)]. The physical model includes plasma density, heat and momentum transport equations along with neutral density, and momentum transport equations. Transport dynamics and profile evolutions of both plasma and neutrals are simulated and compared between GP and SMBI in both poloidal and radial directions, which are quite different from one and the other. It finds that the neutrals can penetrate about four centimeters inside the last closed (magnetic) flux surface during SMBI, while they are all deposited outside of the LCF during GP. It is the radial convection and larger inflowing flux which lead to the deeper penetration depth of SMBI and higher fueling efficiency compared to GP.

  2. Technique of estimation of actual strength of a gas pipeline section at its deformation in landslide action zone

    SciTech Connect (OSTI)

    Tcherni, V.P.

    1996-12-31

    The technique is given which permits determination of stress and strain state (SSS) and estimation of actual strength of a section of a buried main gas pipeline (GP) in the case of its deformation in a landslide action zone. The technique is based on the use of three-dimensional coordinates of axial points of the deformed GP section. These coordinates are received by a full-scale survey. The deformed axis of the surveyed GP section is described by the polynomial. The unknown coefficients of the polynomial can be determined from the boundary conditions at points of connection with contiguous undeformed sections as well as by use of minimization methods in mathematical processing of full-scale survey results. The resulting form of GP section`s axis allows one to determine curvatures and, accordingly, bending moments along all the length of the considered section. The influence of soil resistance to longitudinal displacements of a pipeline is used to determine longitudinal forces. Resulting values of bending moments and axial forces as well as the known value of internal pressure are used to analyze all necessary components of an actual SSS of pipeline section and to estimate its strength by elastic analysis.

  3. Modeling and optimizing of the random atomic spin gyroscope drift based on the atomic spin gyroscope

    SciTech Connect (OSTI)

    Quan, Wei; Lv, Lin Liu, Baiqi

    2014-11-15

    In order to improve the atom spin gyroscope's operational accuracy and compensate the random error caused by the nonlinear and weak-stability characteristic of the random atomic spin gyroscope (ASG) drift, the hybrid random drift error model based on autoregressive (AR) and genetic programming (GP) + genetic algorithm (GA) technique is established. The time series of random ASG drift is taken as the study object. The time series of random ASG drift is acquired by analyzing and preprocessing the measured data of ASG. The linear section model is established based on AR technique. After that, the nonlinear section model is built based on GP technique and GA is used to optimize the coefficients of the mathematic expression acquired by GP in order to obtain a more accurate model. The simulation result indicates that this hybrid model can effectively reflect the characteristics of the ASG's random drift. The square error of the ASG's random drift is reduced by 92.40%. Comparing with the AR technique and the GP + GA technique, the random drift is reduced by 9.34% and 5.06%, respectively. The hybrid modeling method can effectively compensate the ASG's random drift and improve the stability of the system.

  4. Mountable eddy current sensor for in-situ remote detection of surface and sub-surface fatigue cracks

    DOE Patents [OSTI]

    Yepez, III, Esteban; Roach, Dennis P.; Rackow, Kirk A.; DeLong, Waylon A.

    2011-09-06

    A wireless, integrated, mountable, portable, battery-operated, non-contact eddy current sensor that provides similar accuracy to 1970's laboratory scale equipment (e.g., a Hewlett-Packard GP4194A Impedance Analyzer) at a fraction of the size and cost.

  5. BSF-PMM-890082

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GENERAL PROVISIONS FOR COST REIMBURSEMENT CONTRACTS This set of General Provisions consists of Sections A through C. Section C clauses apply only if specifically stated in the Subcontract. (GP/CR 10/12, Rev. 0) Waste Isolation Pilot Plant Carlsbad, New Mexico Rev. 0, October 1, 2012 1 TABLE OF CONTENTS GENERAL PROVISIONS FOR COST REIMBURSEMENT SUBCONTRACTS ARTICLE ................................................................................................................................ PAGE

  6. DEVELOPMENT OF A GEOCHEMICAL MODEL FOR URANIUM TRANSPORT IN THE UNSATURATED AND SATURATED SEDIMENTS AT THE 200 WEST AREA OF THE US DEPARTMENT OF ENERGY HANFORD SITE WASHINGTON (SEPTEMBER 2004)

    SciTech Connect (OSTI)

    ADAMS SC; PETERSEN SW

    2010-03-24

    Final Deliverable under GWP-HQ-LMT-02 contract for Hanford Sci. & Tech. Gp. to BHI. The scope of work covered laboratory analyses and gephysical logging for 299-W19-43 near the 200 West U Plant. Other isotopic analyses were conducted for holes around 216-U-1&2, including U-236.

  7. Adhesion and Wetting of Soft Nanoparticles on Textured Surfaces: Transition between Wenzel and CassieBaxter States

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cao, Zhen; Stevens, Mark J.; Carrillo, Jan-Michael Y.; Dobrynin, Andrey V.

    2015-01-16

    We use a combination of the molecular dynamics simulations and scaling analysis to study interactions between gel-like nanoparticles and substrates covered with rectangular shape posts. Our simulations have shown that nanoparticle in contact with substrate undergo first order transition between Wenzel and Cassie-Baxter state which location depends on nanoparticle shear modulus, the strength of nanoparticle-substrate interactions, height of the substrate posts and nanoparticle size, Rp. There is a range of system parameters where these two states coexist such that the average indentation ? produced by substrate posts changes monotonically with nanoparticle shear modulus, Gp. We have developed a scaling modelmorethat describes deformation of nanoparticle in contact with patterned substrate. In the framework of this model the effect of the patterned substrate can be taken into account by introducing an effective work of adhesion, Weff, which describes the first order transition between Wenzel and Cassie-Baxter states. There are two different shape deformation regimes for nanoparticles with shear modulus Gp and surface tension ?p. Shape of small nanoparticles with size Rp p 3/2Gp-1 Weff-1/2 is controlled by capillary forces while deformation of large nanoparticles, Rp > ?p 3/2Gp-1 Weff-1/2less

  8. Structure of a High-Affinity

    SciTech Connect (OSTI)

    Saphire, E.O.; Montero, M.; Menendez, A.; Houten, N.E.van; Irving, M.B.; Pantophlet, R.; Swick, M.B.; Parren, P.W.H.I.; Burton, D.R.; Scott, J.K.; Wilson, I.A.; /Scripps Res. Inst. /Simon Fraser U. /British Columbia U.

    2007-07-13

    The human antibody b12 recognizes a discontinuous epitope on gp120 and is one of the rare monoclonal antibodies that neutralize a broad range of primary human immunodeficiency virus type 1 (HIV-1) isolates. We previously reported the isolation of B2.1, a dimeric peptide that binds with high specificity to b12 and competes with gp120 for b12 antibody binding. Here, we show that the affinity of B2.1 was improved 60-fold over its synthetic-peptide counterpart by fusing it to the N terminus of a soluble protein. This affinity, which is within an order of magnitude of that of gp120, probably more closely reflects the affinity of the phage-borne peptide. The crystal structure of a complex between Fab of b12 and B2.1 was determined at 1.8 Angstrom resolution. The structural data allowed the differentiation of residues that form critical contacts with b12 from those required for maintenance of the antigenic structure of the peptide, and revealed that three contiguous residues mediate B2.1's critical contacts with b12. This single region of critical contact between the B2.1 peptide and the b12 paratope is unlikely to mimic the discontinuous key binding residues involved in the full b12 epitope for gp120, as previously identified by alanine scanning substitutions on the gp120 surface. These structural observations are supported by experiments that demonstrate that B2.1 is an ineffective immunogenic mimic of the b12 epitope on gp120. Indeed, an extensive series of immunizations with B2.1 in various forms failed to produce gp120 cross-reactive sera. The functional and structural data presented here, however, suggest that the mechanism by which b12 recognizes the two antigens is very different. Here, we present the first crystal structure of peptide bound to an antibody that was originally raised against a discontinuous protein epitope. Our results highlight the challenge of producing immunogens that mimic discontinuous protein epitopes, and the necessity of combining complementary experimental approaches in analyzing the antigenic and immunogenic properties of putative molecular mimics.

  9. Validity of ELTB Equation for Suitable Description of BEC

    SciTech Connect (OSTI)

    Kim, Dooyoung; Kim, Jinguanghao; Yoon, Jin-Hee

    2005-10-17

    The Bose-Einstein condensation (BEC) has been found for various alkali-metal gases such as 7Li, 87Rb, Na, and H. For the description of atoms in this condensate state, the Gross-Pitaevskii (GP) equation has been widely used. However, the GP equation contains the nonlinear term, which makes this equation hard to solve. Therefore, physical quantities are usually obtained numerically, and sometimes it is difficult to extract a physical meaning from the calculated results. The nuclear theory group at Purdue University in the U.S. developed a new simple equation, the equivalent linear two-body (ELTB) equation, using the hyper-radius coordinates and tested it for one-dimensional BEC system. Their results are consistent with the numerical values from the GP equation within 4.5%.We test the validity of the ELTB equation for three-dimensional BEC system by calculating the energies per particle and the wave functions for 87Rb gas and for 7Li gas. We use the quantum-mechanical variational method for the BEC energy. Our result for 87Rb gas agrees with a numerical calculation based on the GP equation, with a relative error of 12% over a wide range of N from 100 to 10,000. The relative distances between particles for 7Li gas are consistent within a relative error of 17% for N {<=} 1300. The relatively simple form of the ELTB equation, compared with the GP equation, enables us to treat the N-body system easily and efficiently. We conclude that the ELTB equation is a powerful equation for describing BEC system because it is easy to treat.

  10. Nano-electromechanical rotation of graphene and giant enhancement in dielectric anisotropy in a liquid crystal

    SciTech Connect (OSTI)

    Basu, Rajratan Kinnamon, Daniel; Garvey, Alfred

    2015-05-18

    A nematic liquid crystal (LC) is doped with dilute concentrations of pristine monolayer graphene (GP) flakes, and the LC + GP hybrids are found to exhibit a dramatic increase in the dielectric anisotropy. Electric field-dependent conductance studies reveal that the graphene flakes follow the nematic director that mechanically rotates on increasing an applied electric field. Further studies show that the ?? electron stacking, between the graphene's honeycomb structure and the LC's benzene rings, stabilizes pseudo-nematic domains that collectively amplify the dielectric anisotropy by improving the orientational order parameter in the nematic phase. These anisotropic domains interact with the external electric field, resulting in a nonzero dielectric anisotropy in the isotropic phase as well. The enhancement in dielectric anisotropy, due to the LCgraphene coupling, is found to have subsequent positive impacts on the LC's orientational threshold field and elasticity that allows the nematic director to respond quicker on switching the electric field off.

  11. CEMI Southeast Regional Summit Speakers | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Speakers CEMI Southeast Regional Summit Speakers The following are confirmed speakers for the CEMI Southeast Regional Summit, which will be held on July 9, 2015 at the Renaissance Atlanta Midtown Hotel in Atlanta, Georgia. Keynote Speakers Dr. David Danielson, Assistant Secretary for Energy Efficiency and Renewable Energy, U.S. Department of Energy Dr. G.P. "Bud" Peterson, President, Georgia Institute of Technology Mr. John "Jay" Rogers, Founder & CEO, Local Motors Panel

  12. SSRL HEADLINES April 2009

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 April, 2009 __________________________________________________________________________ Contents of this Issue: User Safety Update Caution Advised Regarding Swine Flu Outbreak Science Highlight - Novel Mechanism for DNA Biosynthesis in Organisms with Gene thyX could Lead to Better Antibiotics Science Highlight - Finding the Crystal Structure of P-gp: A Protein that Makes Cancer Cells Resistant to Chemotherapy Science Highlight - A New Way to Limit Damaging Production of Nitric Oxide From the

  13. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    P-Glycoprotein Structure and Chemotherapy Resistance Print A research team from the Scripps Research Institute and the Texas Tech University Health Sciences Center has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help scientists design more effective drugs. The structure is

  14. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    P-Glycoprotein Structure and Chemotherapy Resistance Print A research team from the Scripps Research Institute and the Texas Tech University Health Sciences Center has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help scientists design more effective drugs. The structure is

  15. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    P-Glycoprotein Structure and Chemotherapy Resistance Print A research team from the Scripps Research Institute and the Texas Tech University Health Sciences Center has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help scientists design more effective drugs. The structure is

  16. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    P-Glycoprotein Structure and Chemotherapy Resistance Print A research team from the Scripps Research Institute and the Texas Tech University Health Sciences Center has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help scientists design more effective drugs. The structure is

  17. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    P-Glycoprotein Structure and Chemotherapy Resistance P-Glycoprotein Structure and Chemotherapy Resistance Print Wednesday, 27 May 2009 00:00 A research team from the Scripps Research Institute and the Texas Tech University Health Sciences Center has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs.

  18. OFFICE OF MANAGEMENT AND BUDGET

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SF-428S Supplemental Sheet - Attachment to SF-428 OMB Approval Number: TANGIBLE PERSONAL PROPERTY REPORT Supplemental Sheet SF-428S Federal Grant or Other Identifying Number Assigned by Federal Awarding Agency (Block 2 of SF-428) Attachment Type ___ Annual Report ___ Final (Award Closeout) Report ___ Disposition Request/Report Page Of Pages Complete one row for each item: Award Number (a) GP or ACQ (b) Description of Item (c) Identification Number (d) Acq. Date (e) Cond. Code (f) Acq. Cost (g)

  19. L

    Office of Legacy Management (LM)

    * ; ' -f ..". ., ii f J $n!ulm~ & . - 8. Jb w* Icarprm. OlJr -GP oP--*- 5 ;fwle o-*-w 3 3 1953, ~&m$~km&Y~ypr(pt 8 -lfac -- OF zmmsm !tFsmm L m&mhjb ,. *A~ATEP~AU < @YJ I AMlwalmr i%om8m oat Qoatao. n&J Classification Cancelled .~. __. -- .^ .."--.--

  20. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    P-Glycoprotein Structure and Chemotherapy Resistance Print A research team from the Scripps Research Institute and the Texas Tech University Health Sciences Center has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help scientists design more effective drugs. The structure is

  1. P-Glycoprotein Structure and Chemotherapy Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    P-Glycoprotein Structure and Chemotherapy Resistance Print A research team from the Scripps Research Institute and the Texas Tech University Health Sciences Center has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help scientists design more effective drugs. The structure is

  2. LEDS Global Partnership in Action: Advancing Climate-Resilient Low Emission Development Around the World (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2013-11-01

    Many countries around the globe are designing and implementing low emission development strategies (LEDS). These LEDS seek to achieve social, economic, and environmental development goals while reducing long-term greenhouse gas (GHG) emissions and increasing resiliency to climate change impacts. The LEDS Global Partnership (LEDS GP) harnesses the collective knowledge and resources of more than 120 countries and international donor and technical organizations to strengthen climate-resilient low emission development efforts around the world.

  3. Broad Distribution of Energetically Important Contacts across an Extended

    Office of Scientific and Technical Information (OSTI)

    Protein Interface (Journal Article) | SciTech Connect Broad Distribution of Energetically Important Contacts across an Extended Protein Interface Citation Details In-Document Search Title: Broad Distribution of Energetically Important Contacts across an Extended Protein Interface Infection of cells by HIV depends upon profound structural rearrangements within the trimeric viral protein gp41. Critical to this process is the formation of a six-helix bundle in which a set of three N-terminal

  4. Using Multi-scale Dynamic Rupture Models to Improve Ground Motion

    Office of Scientific and Technical Information (OSTI)

    Estimates: ALCF-2 Early Science Program Technical Report (Technical Report) | SciTech Connect Technical Report: Using Multi-scale Dynamic Rupture Models to Improve Ground Motion Estimates: ALCF-2 Early Science Program Technical Report Citation Details In-Document Search Title: Using Multi-scale Dynamic Rupture Models to Improve Ground Motion Estimates: ALCF-2 Early Science Program Technical Report Authors: Ely, G.P. [1] + Show Author Affiliations (LCF) [LCF Publication Date: 2013-10-31 OSTI

  5. 3-D seismology in the Arabian Gulf

    SciTech Connect (OSTI)

    Al-Husseini, M.; Chimblo, R.

    1995-08-01

    Since 1977 when Aramco and GSI (Geophysical Services International) pioneered the first 3-D seismic survey in the Arabian Gulf, under the guidance of Aramco`s Chief Geophysicist John Hoke, 3-D seismology has been effectively used to map many complex subsurface geological phenomena. By the mid-1990s extensive 3-D surveys were acquired in Abu Dhabi, Oman, Qatar and Saudi Arabia. Also in the mid-1990`s Bahrain, Kuwait and Dubai were preparing to record surveys over their fields. On the structural side 3-D has refined seismic maps, focused faults and fractures systems, as well as outlined the distribution of facies, porosity and fluid saturation. In field development, 3D has not only reduced drilling costs significantly, but has also improved the understanding of fluid behavior in the reservoir. In Oman, Petroleum Development Oman (PDO) has now acquired the first Gulf 4-D seismic survey (time-lapse 3D survey) over the Yibal Field. The 4-D survey will allow PDO to directly monitor water encroachment in the highly-faulted Cretaceous Shu`aiba reservoir. In exploration, 3-D seismology has resolved complex prospects with structural and stratigraphic complications and reduced the risk in the selection of drilling locations. The many case studies from Saudi Arabia, Oman, Qatar and the United Arab Emirates, which are reviewed in this paper, attest to the effectiveness of 3D seismology in exploration and producing, in clastics and carbonates reservoirs, and in the Mesozoic and Paleozoic.

  6. Strategic Petroleum Reserve quarterly report

    SciTech Connect (OSTI)

    Not Available

    1991-08-15

    This August 15, 1991, Strategic Petroleum Reserve Quarterly Report describes activities related to the site development, oil acquisition, budget and cost of the Reserve during the period April 1, 1991, through June 30, 1991. The Strategic Petroleum Reserve storage facilities development program is proceeding on schedule. The Reserve's capacity is currently 726 million barrels. A total of 5.5 million barrels of new gross cavern volume was developed at Big Hill and Bayou Choctaw during the quarter. There were no crude oil deliveries to the Strategic Petroleum Reserve during the calendar quarter ending June 30, 1991. Acquisition of crude oil for the Reserve has been suspended since August 2, 1990, following the invasion of Kuwait by Iraq. As of June 30, 1991, the Strategic Petroleum Reserve inventory was 568.5 million barrels. The reorganization of the Office of the Strategic Petroleum Reserve became effective June 28, 1991. Under the new organization, the Strategic Petroleum Reserve Project Management Office in Louisiana will report to the Strategic Petroleum Reserve Program Office in Washington rather than the Oak Ridge Field Office in Tennessee. 2 tabs.

  7. U.S. Crude Oil Imports

    U.S. Energy Information Administration (EIA) Indexed Site

    16,669 220,747 221,117 244,915 237,910 229,402 1920-2016 Persian Gulf 38,247 47,365 49,210 54,496 46,853 44,701 1993-2016 OPEC* 78,078 84,447 86,981 95,282 87,302 85,862 1993-2016 Algeria 1,064 1993-2016 Angola 5,467 5,598 5,725 4,761 5,154 3,463 1993-2016 Ecuador 7,729 7,139 5,721 6,097 10,350 7,133 1993-2016 Indonesia 1,297 1,727 1,329 1,348 1,955 1,004 1993-2016 Iraq 6,079 11,622 8,064 13,844 7,810 7,092 1996-2016 Kuwait 6,337 5,263 4,193 5,972 6,369 8,389 1993-2016 Libya 159 189 2004-2015

  8. U.S. Total Crude Oil and Products Imports

    U.S. Energy Information Administration (EIA) Indexed Site

    80,042 272,798 273,770 301,517 301,768 290,577 1981-2016 Persian Gulf 38,707 47,680 49,847 54,969 47,129 45,649 1993-2016 OPEC* 85,626 90,481 95,080 101,480 94,605 93,098 1993-2016 Algeria 4,364 2,341 3,707 2,282 3,896 5,042 1993-2016 Angola 5,467 5,974 6,930 5,137 5,154 3,844 1993-2016 Ecuador 7,925 7,139 5,721 6,097 10,350 7,133 1993-2016 Indonesia 1,467 1,846 1,330 1,441 1,956 1,004 1993-2016 Iraq 6,079 11,622 8,064 13,844 7,810 7,092 1996-2016 Kuwait 6,337 5,263 4,193 5,972 6,369 8,389

  9. CO sub 2 emissions from developing countries: Better understanding the role of energy in the long term

    SciTech Connect (OSTI)

    Sathaye, J.; Goldman, N.

    1991-07-01

    Recent years have witnessed a growing recognition of the link between emissions of carbon dioxide (CO{sub 2}) and changes in the global climate. of all anthropogenic activities, energy production and use generate the single largest portion of these greenhouse gases. Although developing countries currently account for a small share of global carbon emissions, their contribution is increasing rapidly. Due to the rapid expansion of energy demand in these nations, the developing world's share in global modern energy use rose from 16 to 27 percent between 1970 and 1990. If the growth rates observed over the past 20 years persist, energy demand in developing nations will surpass that in the countries of the Organization for Economic Cooperation and Development (OECD) early in the 21st century. The study seeks to examine the forces that galvanize the growth of energy use and carbon emissions, to assess the likely future levels of energy and CO{sub 2} in selected developing nations and to identify opportunities for restraining this growth. The purpose of this report is to provide the quantitative information needed to develop effective policy options, not to identify the options themselves. A combined study was carried out for the countries of the Gulf Cooperation Council (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and the United Arab Emirates).

  10. CO{sub 2} emissions from developing countries: Better understanding the role of energy in the long term. Volume 4, Ghana, Sierra Leone, Nigeria and the Gulf Cooperation Council (GCC) countries

    SciTech Connect (OSTI)

    Sathaye, J.; Goldman, N.

    1991-07-01

    Recent years have witnessed a growing recognition of the link between emissions of carbon dioxide (CO{sub 2}) and changes in the global climate. of all anthropogenic activities, energy production and use generate the single largest portion of these greenhouse gases. Although developing countries currently account for a small share of global carbon emissions, their contribution is increasing rapidly. Due to the rapid expansion of energy demand in these nations, the developing world`s share in global modern energy use rose from 16 to 27 percent between 1970 and 1990. If the growth rates observed over the past 20 years persist, energy demand in developing nations will surpass that in the countries of the Organization for Economic Cooperation and Development (OECD) early in the 21st century. The study seeks to examine the forces that galvanize the growth of energy use and carbon emissions, to assess the likely future levels of energy and CO{sub 2} in selected developing nations and to identify opportunities for restraining this growth. The purpose of this report is to provide the quantitative information needed to develop effective policy options, not to identify the options themselves. A combined study was carried out for the countries of the Gulf Cooperation Council (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and the United Arab Emirates).

  11. Domestic petroleum-product prices around the world. Survey: free market or government price controls

    SciTech Connect (OSTI)

    Not Available

    1983-01-27

    In this issue, Energy Detente draws from their regular Western and Eastern Hemisphere Fuel Price/Tax Series, each produced monthly, and adds other survey data and analysis for a broad view of 48 countries around the world. They find that seven Latin American nations, including OPEC members Venezuela and Ecuador, are among the ten countries with lowest gasoline prices. In this Fourth Special Price Report, Energy Detente provides a first-time presentation of which prices are government-controlled, and which are free to respond to market forces. South Korea, with fixed prices since 1964, has the highest premium-grade gasoline price in our survey, US $5.38 per gallon. Paraguay, with prices fixed by PETROPAR, the national oil company, has the second highest premium gasoline price, US $4.21 per gallon. Nicaragua, also with government price controls, ranks third highest in the survey, with US $3.38 per gallon for premium gasoline. Kuwait shows the lowest price at US $0.55 per gallon. Several price changes from the previous survey reflect changes in currency exchange as all prices are converted to US dollars. The Energy Detente fuel price/tax series is presented for Western Hemisphere countries.

  12. The impact of rising energy prices on household energy consumption and expenditure patterns: The Persian Gulf crisis as a case example

    SciTech Connect (OSTI)

    Henderson, L.J. ); Poyer, D.A.; Teotia, A.P.S. . Energy Systems Div.)

    1992-09-01

    The Iraqi invasion of Kuwait and the subsequent war between Iraq and an international alliance led by the United States triggered immediate increases in world oil prices. Increases in world petroleum prices and in US petroleum imports resulted in higher petroleum prices for US customers. In this report, the effects of the Persian Gulf War and its aftermath are used to demonstrate the potential impacts of petroleum price changes on majority, black, and Hispanic households, as well as on poor and nonpoor households. The analysis is done by using the Minority Energy Assessment Model developed by Argonne National Laboratory for the US Department of Energy (DOE). The differential impacts of these price increases and fluctuations on poor and minority households raise significant issues for a variety of government agencies, including DOE. Although the Persian Gulf crisis is now over and world oil prices have returned to their prewar levels, the differential impacts of rising energy prices on poor and minority households as a result of any future crisis in the world oil market remains a significant long-term issue.

  13. The motor gasoline industry: Past, present, and future. [Contains glossary

    SciTech Connect (OSTI)

    Not Available

    1991-01-01

    Motor gasoline constitutes the largest single component of US demand for petroleum products and is the Nation's most widely used transportation fuel. Because of its importance as a transportation fuel, motor gasoline has been the focus of several regulatory and tax policy initiatives in recent years. Much of the US refining capacity is specifically geared toward maximizing motor gasoline production, and future investments by the petroleum industry in refining infrastructure are likely to be made largely to produce larger volumes of clean motor gasoline. This report addresses major events and developments that have had an impact on motor gasoline supply, distribution, prices, and demand. The report provides historical perspective as well as analyses of important events from the 1970's and 1980's. Long-term forecasts are provided for the period from 1990 to 2010 in an effort to present and analyze possible future motor gasoline trends. Other forecasts examine the near-term impact of the invasion of Kuwait. 18 figs., 10 tabs.

  14. World crude output overcomes Persian Gulf disruption

    SciTech Connect (OSTI)

    Not Available

    1992-02-01

    Several OPEC producers made good on their promises to replace 2.7 MMbpd of oil exports that vanished from the world market after Iraq took over Kuwait. Even more incredibly, they accomplished this while a breathtaking 1.2- MMbopd reduction in Soviet output took place during the course of 1991. After Abu Dhabi, Indonesia, Iran, Libya, Nigeria, Saudi Arabia and Venezuela turned the taps wide open, their combined output rose 2.95 MMbopd. Put together with a 282,000-bopd increase by Norway and contributions from smaller producers, this enabled world oil production to remain within 400,000 bopd of its 1990 level. The 60.5-MMbopd average was off by just 0.7%. This paper reports that improvement took place in five of eight regions. Largest increases were in Western Europe and Africa. Greatest reductions occurred in Eastern Europe and the Middle East. Fifteen nations produced 1 MMbopd or more last year, compared with 17 during 1990.

  15. Oil and gas development in Middle East in 1987

    SciTech Connect (OSTI)

    Hemer, D.O.; Gohrbandt, K.H.A.; Phillips, C.B.

    1988-10-01

    Petroleum production in Middle East countries during 1987 totaled an estimated 4,500,500,000 bbl (an average rate of 12,330,137 b/d), up slightly from the revised 1986 total of 4,478,972,000 bbl. Iran, Iraq, Syria, and Yemen Arab Republic had significant increases; Kuwait and Saudi Arabia had significant decreases. Production was established for the first time in People's Democratic Republic of Yemen. New fields went on production in Iraq, Oman, People's Democratic Republic of Yemen, and Syria, and significant oil discoveries were reported in Iraq, Oman, People's Democratic Republic of Yemen, Syria, and Yemen Arab Republic. The level of exploration increased in 1987 with new concessions awarded in some countries, drilling and seismic activities on the increase, new regions in mature areas explored for the first time, and significant reserve additions reported in new and old permits. The Iraq-Iran war still had a negative impact in some regions of the Middle East, particularly in and around the Gulf. 11 figs., 4 tabs.

  16. Global warming and the regions in the Middle East

    SciTech Connect (OSTI)

    Alvi, S.H.; Elagib, N.

    1996-12-31

    The announcement of NASA scientist James Hansen made at a United States Senate`s hearing in June 1988 about the onset of global warming ignited a whirlwind of public concern in United States and elsewhere in the world. Although the temperature had shown only a slight shift, its warming has the potential of causing environmental catastrophe. According to atmosphere scientists, the effect of higher temperatures will change rainfall patterns--some areas getting drier, some much wetter. The phenomenon of warming in the Arabian Gulf region was first reported by Alvi for Bahrain and then for Oman. In the recent investigations, the authors have found a similar warming in other regions of the Arabian Gulf and in several regions of Sudan in Africa. The paper will investigate the observed data on temperature and rainfall of Seeb in Oman, Bahrain, International Airport in Kuwait as index stations for the Arabian Gulf and Port Sudan, Khartoum and Malakal in the African Continent of Sudan. Based on various statistical methods, the study will highlight a drying of the regions from the striking increase in temperature and decline of rainfall amount. Places of such environmental behavior are regarded as desertifying regions. Following Hulme and Kelly, desertification is taken to mean land degradation in dryland regions, or the permanent decline in the potential of the land to support biological activity, and hence human welfare. The paper will also, therefore, include the aspect of desertification for the regions under consideration.

  17. The oil policies of the Gulf Arab Nations

    SciTech Connect (OSTI)

    Ripple, R.D.; Hagen, R.E.

    1995-03-01

    At its heart, Arab oil policy is inseparable from Arab economic and social policy. This holds whether we are talking about the Arab nations as a group or each separately. The seven Arab nations covered in this report-Bahrain, Iraq, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates--participate in several organizations focusing on regional cooperation regarding economic development, social programs, and Islamic unity, as well as organizations concerned with oil policies. This report focuses on the oil-related activities of the countries that may reveal the de facto oil policies of the seven Persian Gulf nations. Nevertheless it should be kept in mind that the decision makers participating in the oil policy organizations are also involved with the collaborative efforts of these other organizations. Oil policies of five of the seven Arab nations are expressed within the forums of the Organization of Petroleum Exporting Countries (OPEC) and the Organization of Arab Petroleum Exporting Countries (OAPEC). Only Oman, among the seven, is not a member of either OAPEC or OPEC; Bahrain is a member of OAPEC but not of OPEC. OPEC and OAPEC provide forums for compromise and cooperation among their members. Nevertheless, each member state maintains its own sovereignty and follows its own policies. Each country deviates from the group prescription from time to time, depending upon individual circumstances.

  18. State companies dominate OGJ100 list of non-U. S. oil producers

    SciTech Connect (OSTI)

    Not Available

    1993-09-20

    State owned oil and gas companies dominate the OGJ100 list of non-U.S. producers. Because many of them report only operating information, companies on the worldwide list cannot be ranked by assets or revenues. The list, therefore, is organized regionally, based on location of companies' corporate headquarters. The leading nongovernment company in both reserves and production is Royal Dutch/Shell. It ranks sixth in the world in liquids production and 11th in liquids reserves, as it has for the past 2 years. British Petroleum is the next largest nongovernment company. BP ranks 11th in liquids production and 16th in liquids reserves. Elf Aquitaine, 55.8% government-controlled, ranked 17th in liquids production. AGIP was 20th in liquids production. Kuwait Petroleum returned to the list of top 20 producers, ranking 12th, as it restored production shut in by facilities damage sustained during the Persian Gulf crisis. New to the top 20 reserves list is Petroleo Brasileiro, which moved to 20th position. The top 20 companies in the OGJ100 held reserves estimated at 869.3 billion bbl in 1992 vs. 869.5 billion bbl in 1991 and 854.2 billion bbl in 1990.

  19. Liquid phase methanol LaPorte process development unit: Modification, operation, and support studies

    SciTech Connect (OSTI)

    Not Available

    1990-11-09

    As part of the liquid phase methanol process development program the present study evaluated adsorptive schemes to remove catalyst poisons from coal gas at pilot scale. In addition to a lab test with coal gas from Coolwater, two field tests were performed at Great Plains with live coal gas. In the lab with Coolwater, gas iron carbonyl, carbonyl sulfide,and hydrogen sulfide were effectively removed from the coal gas. The capacities of H-Y zeolite and BPL carbon for Fe(CO){sub 5} agreed well with the previous bench scale results at similar CO{sub 2} partial pressure. COS appeared to be chemisorbed on FCA carbon; its capacity was non-regenerable by hot nitrogen purge. A Cu/Zn catalyst, used to remove H{sub 2}S adsorptively, worked adequately. With the adsorption system on-line, a downstream methanol catalyst showed stable activity for 120 hours of operation. In the two field tests, it was demonstrated that the Great Plains (GP) syngas could be treated by adsorption for LPMEOH process. The catalyst deactivation observed in the first field test was much improved in the second field test after regular (every three days) regeneration of the adsorbents was practiced. The absorption system, which was designed for the removal of iron/nickel carbonyls, hydrogen/carbonyl sulfide and hydrochloric acid, needed to be modified to accommodate other unexpected impurities, such as acetonitrile and ethylene which were observed during both field tests. A lab test with a simulated GP gas indicated that low CO{sub 2} content (0.5%) in the GP gas does not cause catalyst deactivation. Adjusting the CO{sub 2} content of the feed to 5% by CO{sub 2} addition, increased methanol productivity by 40% in both the lab and the second field test. 6 refs., 25 figs., 14 tabs.

  20. 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Comparison of the Data of Airborne, Lidar, and Photometric Sensing of Aerosol Parameters in the Cloudless Atmosphere M.V. Panchenko, V.S. Kozlov, Yu.S. Balin, S.M. Sakerin, G.P. Kokhanenko, L.E. Penner, D.M. Kabanov, E.V. Makienko, S.A. Terpugova, S.A. Turchinovich, and V.P. Shmargunov Institute of Atmospheric Optics SB RAS Tomsk, Russia Introduction A comprehensive investigation of the optical and microphysical parameters of tropospheric aerosol dictates the necessity of applying several

  1. April 2013 Most Viewed Documents for Energy Storage, Conversion, And

    Office of Scientific and Technical Information (OSTI)

    Utilization | OSTI, US Dept of Energy, Office of Scientific and Technical Information April 2013 Most Viewed Documents for Energy Storage, Conversion, And Utilization Science Subject Feed Seventh Edition Fuel Cell Handbook NETL (2004) 628 /> Continuously variable transmissions: theory and practice Beachley, N.H.; Frank, A.A. (null) 205 /> A study of lead-acid battery efficiency near top-of-charge and the impact on PV system design Stevens, J.W.; Corey, G.P. (1996) 173 /> Energy

  2. Science Summary

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chang Research Scripps News Release » Share this Article Laboratree Ologeez SciLink LabSpaces Finding the Crystal Structure of P-gp: A Protein that Makes Cancer Cells Resistant to Chemotherapy summary written by Raven Hanna Medications can be rendered ineffective through cells developing multidrug resistance. This is the case in many forms of cancer cells that fail to respond to chemotherapy. The ability of these cells to avoid the effects of drugs can be due to the actions of P-glycoprotein

  3. Measurement of Muon Capture on the Proton (Journal Article) | SciTech

    Office of Scientific and Technical Information (OSTI)

    Connect Measurement of Muon Capture on the Proton Citation Details In-Document Search Title: Measurement of Muon Capture on the Proton The goal of the {mu}Cap experiment is a 1% precision measurement of the muon capture rate on the free proton, which will determine the weak pseudoscalar form factor gP to 7%. At the end of 2004, the {mu}Cap detector was completed and commissioned and first physics data were taken. The analysis of these data is in an advanced stage. The muon capture rate will

  4. Coincident Aerosol and H2O Retrievals versus HSI Imager Field Campaign Report

    Office of Scientific and Technical Information (OSTI)

    4-041 Coincident Aerosol and H2O Retrievals versus HSI Imager Field Campaign ReportH2O Retrievals versus HSI Imager Field Campaign Report GP Anderson JJ Cipar PS Armstrong J van den Bosch May 2016 ARM CLIMATE RESEARCH FACILITY DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the

  5. Human non-neutralizing HIV-1 envelope monoclonal antibodies limit the number of founder viruses during SHIV mucosal infection in rhesus macaques

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Santra, Sampa; Tomaras, Georgia D.; Warrier, Ranjit; Nicely, Nathan I.; Liao, Hua -Xin; Pollara, Justin; Liu, Pinghuang; Alam, S. Munir; Zhang, Ruijun; Cocklin, Sarah L.; et al

    2015-08-03

    HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4⁺ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies that are most likely protective, they are not induced with current vaccine candidates. In contrast, antibodies that do not neutralize primary HIV-1 strains in the TZM-bl infection assay are readily induced by current vaccine candidates and have also been implicated as secondary correlates of decreased HIV-1 risk in the RV144 vaccine efficacy trial. Here, we have studied the capacity of anti-Env monoclonal antibodies (mAbs) against either the immunodominant regionmore » of gp41 (7B2 IgG1), the first constant region of gp120 (A32 IgG1), or the third variable loop (V3) of gp120 (CH22 IgG1) to modulate in vivo rectal mucosal transmission of a high-dose simian-human immunodeficiency virus (SHIV-BaL) in rhesus macaques. 7B2 IgG1 or A32 IgG1, each containing mutations to enhance Fc function, was administered passively to rhesus macaques but afforded no protection against productive clinical infection while the positive control antibody CH22 IgG1 prevented infection in 4 of 6 animals. Enumeration of transmitted/founder (T/F) viruses revealed that passive infusion of each of the three antibodies significantly reduced the number of T/F genomes. Some antibodies that bind HIV-1 Env but fail to neutralize virus in traditional neutralization assays may limit the number of T/F viruses involved in transmission without leading to enhancement of viral infection. For one of these mAbs, gp41 mAb 7B2, we provide the first co-crystal structure in complex with a common cyclical loop motif demonstrated to be critical for infection by other retroviruses.« less

  6. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Performance of Longwave Radiative Transfer Models for 3D Cloud Fields Download a printable PDF Submitter: Kablick III, G. P., University of Maryland Ellingson, R. G., Florida State University Area of Research: Radiation Processes Working Group(s): Cloud Life Cycle Journal Reference: Kablick III GP, RG Ellingson, EE Takara, and J Gu. 2011. "Longwave 3D benchmarks for inhomogeneous clouds and comparisons with approximate methods." Journal of Climate, 24, doi:10.1175/2010JCLI3752.1. The

  7. Gravitomagnetic gyroscope precession in Palatini f(R) gravity

    SciTech Connect (OSTI)

    Ruggiero, Matteo Luca

    2009-04-15

    We study gravitomagnetic effects in the Palatini formalism of f(R) gravity. On using the Kerr-de Sitter metric, which is a solution of f(R) field equations, we calculate the impact of f(R) gravity on the gravitomagnetic precession of an orbiting gyroscope. We show that, even though an f(R) contribution is present in principle, its magnitude is negligibly small and far to be detectable in the present (like GP-B) and foreseeable space missions or observational tests around the Earth.

  8. July 2013 Most Viewed Documents for Energy Storage, Conversion, And

    Office of Scientific and Technical Information (OSTI)

    Utilization | OSTI, US Dept of Energy, Office of Scientific and Technical Information July 2013 Most Viewed Documents for Energy Storage, Conversion, And Utilization Science Subject Feed Process Equipment Cost Estimation, Final Report H.P. Loh; Jennifer Lyons; Charles W. White, III (2002) 567 /> A study of lead-acid battery efficiency near top-of-charge and the impact on PV system design Stevens, J.W.; Corey, G.P. (1996) 142 /> Seventh Edition Fuel Cell Handbook NETL (2004) 133 />

  9. Human non-neutralizing HIV-1 envelope monoclonal antibodies limit the number of founder viruses during SHIV mucosal infection in rhesus macaques

    SciTech Connect (OSTI)

    Santra, Sampa; Tomaras, Georgia D.; Warrier, Ranjit; Nicely, Nathan I.; Liao, Hua -Xin; Pollara, Justin; Liu, Pinghuang; Alam, S. Munir; Zhang, Ruijun; Cocklin, Sarah L.; Shen, Xiaoying; Duffy, Ryan; Xia, Shi -Mao; Schutte, Robert J.; Pemble IV, Charles W.; Dennison, S. Moses; Li, Hui; Chao, Andrew; Vidnovic, Kora; Evans, Abbey; Klein, Katja; Kumar, Amit; Robinson, James; Landucci, Gary; Forthal, Donald N.; Montefiori, David C.; Kaewkungwal, Jaranit; Nitayaphan, Sorachai; Pitisuttithum, Punnee; Rerks-Ngarm, Supachai; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.; Soderberg, Kelly A.; Giorgi, Elena E.; Blair, Lily; Korber, Bette T.; Moog, Christiane; Shattock, Robin J.; Letvin, Norman L.; Schmitz, Joern E.; Moody, M. A.; Gao, Feng; Ferrari, Guido; Shaw, George M.; Haynes, Barton F.; Douek, Daniel C.

    2015-08-03

    HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4⁺ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies that are most likely protective, they are not induced with current vaccine candidates. In contrast, antibodies that do not neutralize primary HIV-1 strains in the TZM-bl infection assay are readily induced by current vaccine candidates and have also been implicated as secondary correlates of decreased HIV-1 risk in the RV144 vaccine efficacy trial. Here, we have studied the capacity of anti-Env monoclonal antibodies (mAbs) against either the immunodominant region of gp41 (7B2 IgG1), the first constant region of gp120 (A32 IgG1), or the third variable loop (V3) of gp120 (CH22 IgG1) to modulate in vivo rectal mucosal transmission of a high-dose simian-human immunodeficiency virus (SHIV-BaL) in rhesus macaques. 7B2 IgG1 or A32 IgG1, each containing mutations to enhance Fc function, was administered passively to rhesus macaques but afforded no protection against productive clinical infection while the positive control antibody CH22 IgG1 prevented infection in 4 of 6 animals. Enumeration of transmitted/founder (T/F) viruses revealed that passive infusion of each of the three antibodies significantly reduced the number of T/F genomes. Some antibodies that bind HIV-1 Env but fail to neutralize virus in traditional neutralization assays may limit the number of T/F viruses involved in transmission without leading to enhancement of viral infection. For one of these mAbs, gp41 mAb 7B2, we provide the first co-crystal structure in complex with a common cyclical loop motif demonstrated to be critical for infection by other retroviruses.

  10. 1992ApJ...399L..51G

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Information 90s To view OSTI Historical Photo Gallery, you can browse the collections below. 1940s | 1950s | 1960s | 1970s | 1980s | 2000s 1990: Hammer Award 1990: SIS 1991: Manager 1991-1996 Elizabeth Buffum 1991: Energy Research Abstracts (ERA) 1994: Demonstration of US Department of Energy Website 1997: Manager 1997-Present Walter L. Warnick

    2ApJ...399L..51G 1992ApJ...399L..51G 1992ApJ...399L..51G 1992ApJ...399L..51G>

  11. A General Investigation of Optimized Atmospheric Sample Duration

    SciTech Connect (OSTI)

    Eslinger, Paul W.; Miley, Harry S.

    2012-11-28

    ABSTRACT The International Monitoring System (IMS) consists of up to 80 aerosol and xenon monitoring systems spaced around the world that have collection systems sensitive enough to detect nuclear releases from underground nuclear tests at great distances (CTBT 1996; CTBTO 2011). Although a few of the IMS radionuclide stations are closer together than 1,000 km (such as the stations in Kuwait and Iran), many of them are 2,000 km or more apart. In the absence of a scientific basis for optimizing the duration of atmospheric sampling, historically scientists used a integration times from 24 hours to 14 days for radionuclides (Thomas et al. 1977). This was entirely adequate in the past because the sources of signals were far away and large, meaning that they were smeared over many days by the time they had travelled 10,000 km. The Fukushima event pointed out the unacceptable delay time (72 hours) between the start of sample acquisition and final data being shipped. A scientific basis for selecting a sample duration time is needed. This report considers plume migration of a nondecaying tracer using archived atmospheric data for 2011 in the HYSPLIT (Draxler and Hess 1998; HYSPLIT 2011) transport model. We present two related results: the temporal duration of the majority of the plume as a function of distance and the behavior of the maximum plume concentration as a function of sample collection duration and distance. The modeled plume behavior can then be combined with external information about sampler design to optimize sample durations in a sampling network.

  12. Oil prices in a new light

    SciTech Connect (OSTI)

    Fesharaki, F. )

    1994-05-01

    For a clear picture of how oil prices develop, the author steps away from the price levels to which the world is accustomed, and evaluates scientifically. What makes prices jump from one notch to another The move results from a political or economic shock or the perception of a particular position by the futures market and the media. The shock could range from a war or an assassination to a promise of cooperation among OPEC members (when believed by the market) or to speculation about another failure at an OPEC meeting. In the oil market, only a couple of factual figures can provide a floor to the price of oil. The cost of production of oil in the Gulf is around $2 to $3/bbl, and the cost of production of oil (capital and operating costs) in key non-OPEC areas is well under $10/bbl. With some adjustments for transport and quality, a price range of $13/bbl to $16/bbl would correspond to a reasonable sustainable floor price. The reason for prices above the floor price has been a continuous fear of oil supply interruptions. That fear kept prices above the floor price for many years. The fear factor has now almost fully disappeared. The market has gone through the drama of the Iranian Revolution, the Iran-Iraq war, the tanker war, the invasion of Kuwait, and the expulsions of the Iraqis. And still the oil flowed -- all the time. It has become abundantly clear that fears above the oil market were unjustified. Everyone needs to export oil, and oil will flow under the worst circumstances. The demise of the fear factor means that oil prices tend toward the floor price for a prolonged period.

  13. Political dynamics of economic sanctions: a case study of Arab oil embargoes

    SciTech Connect (OSTI)

    Daoudi, M.S.

    1981-01-01

    The general question is considered of the effectiveness of economic sanctions in international politics, in terms of the Arabs' use of oil as a political weapon in 1956, 1967, and 1973. Chapter 3 focuses on the impact of the interruption of oil supplies to Western Europe throughout the 1956 Suez crisis. By 1967, pressure on the conservative governing elites of Saudi Arabia, Kuwait, Libya, and the Gulf Sheikdoms obliged these states to join Iraq and Algeria in imposing production cutbacks and an embargo. Yet the conservative regimes' ties to the West, and the control exerted by multinational oil corporations over all phases of their oil industry, insured that the embargo was not enforced. Chapter 4 explains historically how, by the late 1960s, relinquishment of old concessions, nationalization acts, and participation agreements had caused a decline in the multinationals' domination of the oil industry. The rise of OPEC and OAPEC, which by 1970 had united and organized the producing governments, channeled their demands, and created an international forum for their political grievances, is discussed. Chapter 5 considers how by 1973 international and Arab political developments had forced states like Saudi Arabia, which had sought to dissociate oil and politics, to unsheathe the oil weapon and wave it in the faces of their Western allies. The author concludes from analysis of these complex cases that scholarship has exaggerated the inefficacy of sanctions. The effectiveness of sanctions is seen to depend upon how the demands are formulated and presented and to what extent they can be negotiated, as well as upon the sociopolitical, cultural, and psychological characteristics of the target population.

  14. Polysulfone and polyacrylate-based zwitterionic coatings for the prevention and easy removal of marine biofouling

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hibbs, Michael R.; Hernandez-Sanchez, Bernadette A.; Daniels, Justin; Stafslien, Shane J.

    2015-09-07

    A series of polysulfone and polyacrylate-based zwitterionic coatings were prepared on epoxy-primed aluminum substrata and characterized for their antifouling (AF) and fouling-release (FR) properties towards marine bacteria, microalgae and barnacles. The zwitterionic polymer coatings provided minimal resistance against bacterial biofilm retention and microalgal cell attachment, but facilitated good removal of attached microbial biomass by exposure to water-jet apparatus generated hydrodynamic shearing forces. Increasing the ion content of the coatings improved the AF properties, but required a stronger adhesive bond to the epoxy-primed aluminum substratum to prevent coating swelling and dissolution. Grafted poly(sulfobetaine) (gpSBMA), the most promising zwitterionic coating identified frommore » microfouling evaluations, enabled the removal of four out of five barnacles reattached to its surface without incurring damage to their baseplates. As a result, this significant result indicated that gpSBMA relied predominately on its surface chemistry for its FR properties since it was very thin (~1–2 µm) relative to commercial coating standards (>200 µm).« less

  15. Demonstration of emulator-based Bayesian calibration of safety analysis codes: Theory and formulation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yurko, Joseph P.; Buongiorno, Jacopo; Youngblood, Robert

    2015-05-28

    System codes for simulation of safety performance of nuclear plants may contain parameters whose values are not known very accurately. New information from tests or operating experience is incorporated into safety codes by a process known as calibration, which reduces uncertainty in the output of the code and thereby improves its support for decision-making. The work reported here implements several improvements on classic calibration techniques afforded by modern analysis techniques. The key innovation has come from development of code surrogate model (or code emulator) construction and prediction algorithms. Use of a fast emulator makes the calibration processes used here withmore » Markov Chain Monte Carlo (MCMC) sampling feasible. This study uses Gaussian Process (GP) based emulators, which have been used previously to emulate computer codes in the nuclear field. The present work describes the formulation of an emulator that incorporates GPs into a factor analysis-type or pattern recognition-type model. This “function factorization” Gaussian Process (FFGP) model allows overcoming limitations present in standard GP emulators, thereby improving both accuracy and speed of the emulator-based calibration process. Calibration of a friction-factor example using a Method of Manufactured Solution is performed to illustrate key properties of the FFGP based process.« less

  16. Towards a Resolution of the Proton Form Factor Problem: New Electron and Positron Scattering Data

    SciTech Connect (OSTI)

    Adikaram, D.; Rimal, D.; Weinstein, L. B.; Raue, B.; Khetarpal, P.; Bennett, R.; Arrington, J.; Brooks, W.; Adhikari, K.; Afanasev, A.; Amaryan, M.; Anderson, M.; Anefalos Pereira, S.; Avakian, H.; Ball, J.; Battaglieri, M.; Bedlinskiy, I.; Biselli, A.; Bono, J.; Boiarinov, S.; Briscoe, W.; Burkert, V.; Carman, D.; Careccia, S.; Celentano, A.; Chandavar, S.; Charles, G.; Colaneri, L.; Cole, P.; Contalbrigo, M.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Deur, A.; Djalali, C.; Dodge, G.; Dupre, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Filippi, A.; Fleming, J.; Fradi, A.; Garillon, B.; Gilfoyle, G.; Giovanetti, K.; Girod, F.; Goetz, J.; Gohn, W.; Golovatch, E.; Gothe, R.; Griffioen, K.; Guegan, B.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Harrison, N.; Hattawy, M.; Hicks, K.; Holtrop, M.; Hughes, S.; Hyde, C. E.; Ilieva, Y.; Ireland, D.; Ishkhanov, B.; Jenkins, D.; Jiang, H.; Jo, H.; Joo, K.; Joosten, S.; Kalantarians, N.; Keller, D.; Khandaker, M.; Kim, A.; Kim, W.; Klein, A.; Klein, F.; Koirala, S.; Kubarovsky, V.; Kuhn, S.; Livingston, K.; Lu, H.; MacGregor, I.; Markov, N.; Mattione, P.; Mayer, M.; McKinnon, B.; Mestayer, M.; Meyer, C.; Mirazita, M.; Mokeev, V.; Montgomery, R.; Moody, C.; Moutarde, H.; Movsisyan, A.; Camacho, C. Munoz; Nadel-Turonski, P.; Niccolai, S.; Niculescu, G.; Osipenko, M.; Ostrovidov, A.; Park, K.; Pasyuk, E.; Pisano, S.; Pogorelko, O.; Price, J.; Procureur, S.; Prok, Y.; Protopopescu, D.; Puckett, A.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabati, F.; Salgado, C.; Schott, D.; Schumacher, R.; Seder, E.; Sharabian, Y.; Simonyan, A.; Skorodumina, I.; Smith, E.; Smith, G.; Sober, D.; Sokhan, D.; Sparveris, N.; Stepanyan, S.; Stoler, P.; Strauch, S.; Sytnik, V.; Taiuti, M.; Tian, Ye; Trivedi, A.; Ungaro, M.; Voskanyan, H.; Voutier, E.; Walford, N.; Watts, D.; Wei, X.; Wood, M.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z.; Zonta, I.

    2015-02-10

    There is a significant discrepancy between the values of the proton electric form factor, GpE, extracted using unpolarized and polarized electron scattering. Calculations predict that small two-photon exchange (TPE) contributions can significantly affect the extraction of GpE from the unpolarized electron-proton cross sections. We determined the TPE contribution by measuring the ratio of positron-proton to electron-proton elastic scattering cross sections using a simultaneous, tertiary electron-positron beam incident on a liquid hydrogen target and detecting the scattered particles in the Jefferson Lab CLAS detector. This novel technique allowed us to cover a wide range in virtual photon polarization (epsilon) and momentum transfer (Q2) simultaneously, as well as to cancel luminosity-related systematic errors. The cross section ratio increases with decreasing ε at Q2=1.45 GeV2. This measurement is consistent with the size of the form factor discrepancy at Q2≈1.75 GeV2 and with hadronic calculations including nucleon and Delta intermediate states, which have been shown to resolve the discrepancy up to 2-3 GeV2.

  17. Polysulfone and polyacrylate-based zwitterionic coatings for the prevention and easy removal of marine biofouling

    SciTech Connect (OSTI)

    Hibbs, Michael R.; Hernandez-Sanchez, Bernadette A.; Daniels, Justin; Stafslien, Shane J.

    2015-09-07

    A series of polysulfone and polyacrylate-based zwitterionic coatings were prepared on epoxy-primed aluminum substrata and characterized for their antifouling (AF) and fouling-release (FR) properties towards marine bacteria, microalgae and barnacles. The zwitterionic polymer coatings provided minimal resistance against bacterial biofilm retention and microalgal cell attachment, but facilitated good removal of attached microbial biomass by exposure to water-jet apparatus generated hydrodynamic shearing forces. Increasing the ion content of the coatings improved the AF properties, but required a stronger adhesive bond to the epoxy-primed aluminum substratum to prevent coating swelling and dissolution. Grafted poly(sulfobetaine) (gpSBMA), the most promising zwitterionic coating identified from microfouling evaluations, enabled the removal of four out of five barnacles reattached to its surface without incurring damage to their baseplates. As a result, this significant result indicated that gpSBMA relied predominately on its surface chemistry for its FR properties since it was very thin (~1–2 µm) relative to commercial coating standards (>200 µm).

  18. The role of blood cell membrane lipids on the mode of action of HIV-1 fusion inhibitor sifuvirtide

    SciTech Connect (OSTI)

    Matos, Pedro M.; Freitas, Teresa; Castanho, Miguel A.R.B.; Santos, Nuno C.

    2010-12-17

    Research highlights: {yields} Sifuvirtide interacts with erythrocyte and lymphocyte membrane in a concentration dependent manner by decreasing its dipole potential. {yields} Dipole potential variations in lipid vesicles show sifuvirtide's lipid selectivity towards saturated phosphatidylcholines. {yields} This peptide-membrane interaction may direct the drug towards raft-like membrane domains where the receptors used by HIV are located, facilitating its inhibitory action. -- Abstract: Sifuvirtide is a gp41 based peptide that inhibits HIV-1 fusion with the host cells and is currently under clinical trials. Previous studies showed that sifuvirtide partitions preferably to saturated phosphatidylcholine lipid membranes, instead of fluid-phase lipid vesicles. We extended the study to the interaction of the peptide with circulating blood cells, by using the dipole potential sensitive probe di-8-ANEPPS. Sifuvirtide decreased the dipole potential of erythrocyte and lymphocyte membranes in a concentration dependent manner, demonstrating its interaction. Also, the lipid selectivity of the peptide towards more rigid phosphatidylcholines was confirmed based on the dipole potential variations. Overall, the interaction of the peptide with the cell membranes is a contribution of different lipid preferences that presumably directs the peptide towards raft-like domains where the receptors are located, facilitating the reach of the peptide to its molecular target, the gp41 in its pre-fusion conformation.

  19. Atomic structure of Cu-10. 9 at % Be alloys in the early stages of aging

    SciTech Connect (OSTI)

    Koo, Y.M.

    1987-01-01

    Diffuse x-ray scattering was employed to investigate the local atomic structure and static strains in a single crystal of a Cu-10.9 at. % Be alloy in the early stages of aging. In addition to these experiments, neutron elastic and inelastic scattering were obtained to investigate the phonon properties in the as-quenched state of this alloy. In the as-quenched state, there is a nearly regular array of small ellipsoidal Be clusters aligned along <100> directions (This produces the tweed contrast seen in TEM). The density of these clusters is 7.5 x 10/sup 26//m/sup 3/. The diffuse streaks seen in electron diffraction patterns are due largely to thermal diffuse scattering. Phonon-dispersion curves show no large differences from those of pure copper, except at (xi xi xi)/sub T/ zone boundary, where there is softening. This difference may be due to a Kohn anomaly. The elastic anisotropy of this alloy increases considerably with alloying, which probably leads to the plate-like GP zone morphology in subsequent aging treatments. The structure of the GP zones is a mixture of Be-rich single- and multi-layered zones. As aging proceeds, the zones grow in thickness.

  20. Preparation and Characterization of Carbon Pellets from Pre-Carbonized Mangrove Leaves

    SciTech Connect (OSTI)

    Deraman, Mohamad; Mohtar, Mazliza; Jumali, Mohd Hafizuddin; Omar, Ramli; Yunus, Rozan Mohamad; Aziz, Astimar Abd; Senin, H. B.

    2007-05-09

    Mangrove leaves (ML) were pre-carbonized at low carbonization temperature, ball milled for 36 hours and followed by sieving to obtain powder (SACG) with particle size less than 53 micron and then pelletized into green pellets (GP). A multi-step heating profile which was previously proven suitable for producing 'crack-free' carbon pellets (CP) from the GP of the SACG from oil palm empty fruit bunch (EFB) was found to be suitable for producing CP from the SACG of the ML. Themogravimetri results on the SACG show that in comparison to the SACG-EFB, the SACG-ML decomposed with a lower rate of weight loss within a wider range of the temperature region and it maximum rate occurs at the slightly higher temperature. X-ray diffraction results found that both types the SACG retain their lignocellulosic structure. The density of CP produced up to the carbonization temperatures of 700 deg. C and 1000 deg. C respectively were found to be in the range from 0.94 to 1.03 gcm-3 and 0.98 to 1.28 gcm-3 for the ML and EFB samples respectively. X-ray diffraction results on the CP found that both type of samples have turbostratic structure, with their interlayer spacing d002 decrease with increasing carbonization temperature; that is from 3.79 Aa to 3.43 Aa for the ML samples and 3.82 Aa to 3.68 Aa for the EFB samples.

  1. The human PECAM1 gene maps to 17q23

    SciTech Connect (OSTI)

    Gumina, R.J.; Rao, P.N.; Tuinen, P. van

    1996-06-01

    We have determined the chromosomal and regional location of the gene encoding PECAM-1 (termed PECAM1 by GBI) nomenclature using a polymerase chain reaction (PCR)-based analysis of somatic cell hybrids. Analysis of a somatic cell hybrid chromosome panel established that the PECAM1 gene is on chromosome 17. Interestingly, several adhesion molecules expressed on platelets and endothelium also localize to chromosome 17: the GP1BA locus (glycoprotein (GP) Ib{alpha}) has been provisionally mapped to the region 17p12-pter, the ITGA2b (GPIIb) and the ITGB3 (GPI-IIa) loci have been confirmed to the region 17q21.32; and the ICAM2 locus has been provisionally mapped to the region 17q23-q25. To determine if the PECAM1 locus colocalizes with any of the loci for these adhesion molecules, PCR-based analysis of a regional mapping panel for human chromosome 17 was conducted. We found that the PECAM1 locus is on the long arm of chromosome 17, i the region q23-qter. To confirm this observation and obtain a more precise localization of the PECAM1 locus, fluorescence in situ hybridization was conducted. Together our data allowed assignment of the PECAM1 locus to the region 17q23. 18 refs., 2 figs.

  2. Towards a Resolution of the Proton Form Factor Problem: New Electron and Positron Scattering Data

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adikaram, D.; Rimal, D.; Weinstein, L. B.; Raue, B.; Khetarpal, P.; Bennett, R.; Arrington, J.; Brooks, W.; Adhikari, K.; Afanasev, A.; et al

    2015-02-10

    There is a significant discrepancy between the values of the proton electric form factor, GpE, extracted using unpolarized and polarized electron scattering. Calculations predict that small two-photon exchange (TPE) contributions can significantly affect the extraction of GpE from the unpolarized electron-proton cross sections. We determined the TPE contribution by measuring the ratio of positron-proton to electron-proton elastic scattering cross sections using a simultaneous, tertiary electron-positron beam incident on a liquid hydrogen target and detecting the scattered particles in the Jefferson Lab CLAS detector. This novel technique allowed us to cover a wide range in virtual photon polarization (epsilon) and momentummore » transfer (Q2) simultaneously, as well as to cancel luminosity-related systematic errors. The cross section ratio increases with decreasing ε at Q2=1.45 GeV2. This measurement is consistent with the size of the form factor discrepancy at Q2≈1.75 GeV2 and with hadronic calculations including nucleon and Delta intermediate states, which have been shown to resolve the discrepancy up to 2-3 GeV2.« less

  3. Demonstration of emulator-based Bayesian calibration of safety analysis codes: Theory and formulation

    SciTech Connect (OSTI)

    Yurko, Joseph P.; Buongiorno, Jacopo; Youngblood, Robert

    2015-05-28

    System codes for simulation of safety performance of nuclear plants may contain parameters whose values are not known very accurately. New information from tests or operating experience is incorporated into safety codes by a process known as calibration, which reduces uncertainty in the output of the code and thereby improves its support for decision-making. The work reported here implements several improvements on classic calibration techniques afforded by modern analysis techniques. The key innovation has come from development of code surrogate model (or code emulator) construction and prediction algorithms. Use of a fast emulator makes the calibration processes used here with Markov Chain Monte Carlo (MCMC) sampling feasible. This study uses Gaussian Process (GP) based emulators, which have been used previously to emulate computer codes in the nuclear field. The present work describes the formulation of an emulator that incorporates GPs into a factor analysis-type or pattern recognition-type model. This “function factorization” Gaussian Process (FFGP) model allows overcoming limitations present in standard GP emulators, thereby improving both accuracy and speed of the emulator-based calibration process. Calibration of a friction-factor example using a Method of Manufactured Solution is performed to illustrate key properties of the FFGP based process.

  4. Application of Gaussian Process Modeling to Analysis of Functional Unreliability

    SciTech Connect (OSTI)

    R. Youngblood

    2014-06-01

    This paper applies Gaussian Process (GP) modeling to analysis of the functional unreliability of a “passive system.” GPs have been used widely in many ways [1]. The present application uses a GP for emulation of a system simulation code. Such an emulator can be applied in several distinct ways, discussed below. All applications illustrated in this paper have precedents in the literature; the present paper is an application of GP technology to a problem that was originally analyzed [2] using neural networks (NN), and later [3, 4] by a method called “Alternating Conditional Expectations” (ACE). This exercise enables a multifaceted comparison of both the processes and the results. Given knowledge of the range of possible values of key system variables, one could, in principle, quantify functional unreliability by sampling from their joint probability distribution, and performing a system simulation for each sample to determine whether the function succeeded for that particular setting of the variables. Using previously available system simulation codes, such an approach is generally impractical for a plant-scale problem. It has long been recognized, however, that a well-trained code emulator or surrogate could be used in a sampling process to quantify certain performance metrics, even for plant-scale problems. “Response surfaces” were used for this many years ago. But response surfaces are at their best for smoothly varying functions; in regions of parameter space where key system performance metrics may behave in complex ways, or even exhibit discontinuities, response surfaces are not the best available tool. This consideration was one of several that drove the work in [2]. In the present paper, (1) the original quantification of functional unreliability using NN [2], and later ACE [3], is reprised using GP; (2) additional information provided by the GP about uncertainty in the limit surface, generally unavailable in other representations, is discussed; (3) a simple forensic exercise is performed, analogous to the inverse problem of code calibration, but with an accident management spin: given an observation about containment pressure, what can we say about the system variables? References 1. For an introduction to GPs, see (for example) Gaussian Processes for Machine Learning, C. E. Rasmussen and C. K. I. Williams (MIT, 2006). 2. Reliability Quantification of Advanced Reactor Passive Safety Systems, J. J. Vandenkieboom, PhD Thesis (University of Michigan, 1996). 3. Z. Cui, J. C. Lee, J. J. Vandenkieboom, and R. W. Youngblood, “Unreliability Quantification of a Containment Cooling System through ACE and ANN Algorithms,” Trans. Am. Nucl. Soc. 85, 178 (2001). 4. Risk and Safety Analysis of Nuclear Systems, J. C. Lee and N. J. McCormick (Wiley, 2011). See especially §11.2.4.

  5. PDSF User Meeting 02-04-14.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 , 2 014 Lisa Gerhardt Utilization --- 2 --- Past Outages * Eliza2 ( 12/27 - 1 /10 ) : M ul?ple d isk f ailures * Re?red: E liza 7 o n 1 /17 * Status of e lizas: hGp://www.nersc.gov/users/computa?onal---systems/ pdsf/hardware---configura?on/eliza---file---systems/ Planned Outages * February 1 1 - A ll d ay: G lobal N ERSC o utage. P DSF soUware a nd s ecurity u pdates, N ERSC n etwork, project fi le s ystem - IO r esources s et t o z ero 2 /10 6 :00 p m, u sers c an r un j obs without I O r

  6. Analysis of Neutral Transport in the GAMMA10 Anchor-Cell Using H{alpha}-Emission Detectors

    SciTech Connect (OSTI)

    Higashizono, Y. [Plasma Research Center, University of Tsukuba (Japan); Nakashima, Y. [Plasma Research Center, University of Tsukuba (Japan); Ohki, T. [Plasma Research Center, University of Tsukuba (Japan); Islam, M.K. [Plasma Research Center, University of Tsukuba (Japan); Shoji, M. [National Institute for Fusion Science (Japan); Kobayashi, S. [Institute of Advanced Energy, Kyoto University (Japan); Yoshikawa, M. [Plasma Research Center, University of Tsukuba (Japan); Kubota, Y. [Plasma Research Center, University of Tsukuba (Japan); Kobayashi, T. [Plasma Research Center, University of Tsukuba (Japan); Murakami, R. [Plasma Research Center, University of Tsukuba (Japan); Yamada, M. [Plasma Research Center, University of Tsukuba (Japan); Cho, T. [Plasma Research Center, University of Tsukuba (Japan)

    2005-01-15

    The neutral transport was studied in the anchor cell. The H{alpha} line intensities were measured by using axially aligned H{alpha} detectors. It was found that the intensity is considerably dependent on ECRH and GP 3,4. A 5ch H{alpha} detector was newly installed in the outer-transition region of the anchor-cell. From the measurement of the spatial distributions, the vertical intensity profile is estimated to be about 2.5 cm on the half width half maximum, while the horizontal distribution shows roughly flat around Z=-670 cm. The above characteristics were discussed with aid of neutral transport simulation using DEGAS Monte-Carlo Code.

  7. Fast Change Point Detection for Electricity Market Analysis

    SciTech Connect (OSTI)

    UC Berkeley; Gu, William; Choi, Jaesik; Gu, Ming; Simon, Horst; Wu, Kesheng

    2013-08-25

    Electricity is a vital part of our daily life; therefore it is important to avoid irregularities such as the California Electricity Crisis of 2000 and 2001. In this work, we seek to predict anomalies using advanced machine learning algorithms. These algorithms are effective, but computationally expensive, especially if we plan to apply them on hourly electricity market data covering a number of years. To address this challenge, we significantly accelerate the computation of the Gaussian Process (GP) for time series data. In the context of a Change Point Detection (CPD) algorithm, we reduce its computational complexity from O($n^{5}$) to O($n^{2}$). Our efficient algorithm makes it possible to compute the Change Points using the hourly price data from the California Electricity Crisis. By comparing the detected Change Points with known events, we show that the Change Point Detection algorithm is indeed effective in detecting signals preceding major events.

  8. Evaluation of the Tellabs 1150 GPON multiservice access platform.

    SciTech Connect (OSTI)

    Brenkosh, Joseph Peter; Wolf, Jimmie V.

    2014-11-01

    For over two years, Sandia National Laboratories has been using a Gigabit Passive Optical Network (GPON) access layer for selected networks. The GPON equipment includes the Tellabs 1150 Multiservice Access Platform (MSAP) Optical Line Terminal (OLT), the Tellabs ONT709 and ONT709GP Optical Network Terminals (ONTs), and the Panorama PON Network Manager. In late 2013, the Tellabs equipment was updated to Software Release FP27.1_015130. Because a new software release has the potential to affect performance and functionality, it needed to be thoroughly tested. This report documents that testing. It also provides a comparison between the current release and the previous Software Release FP25.5.1_013274 that was being used.

  9. Penetrator reliability investigation and design exploration : from conventional design processes to innovative uncertainty-capturing algorithms.

    SciTech Connect (OSTI)

    Martinez-Canales, Monica L.; Heaphy, Robert; Gramacy, Robert B.; Taddy, Matt; Chiesa, Michael L.; Thomas, Stephen W.; Swiler, Laura Painton; Hough, Patricia Diane; Lee, Herbert K. H.; Trucano, Timothy Guy; Gray, Genetha Anne

    2006-11-01

    This project focused on research and algorithmic development in optimization under uncertainty (OUU) problems driven by earth penetrator (EP) designs. While taking into account uncertainty, we addressed three challenges in current simulation-based engineering design and analysis processes. The first challenge required leveraging small local samples, already constructed by optimization algorithms, to build effective surrogate models. We used Gaussian Process (GP) models to construct these surrogates. We developed two OUU algorithms using 'local' GPs (OUU-LGP) and one OUU algorithm using 'global' GPs (OUU-GGP) that appear competitive or better than current methods. The second challenge was to develop a methodical design process based on multi-resolution, multi-fidelity models. We developed a Multi-Fidelity Bayesian Auto-regressive process (MF-BAP). The third challenge involved the development of tools that are computational feasible and accessible. We created MATLAB{reg_sign} and initial DAKOTA implementations of our algorithms.

  10. Relative concordance of human immunodeficiency virus oligomeric and monomeric envelope in CCR5 coreceptor usage

    SciTech Connect (OSTI)

    Teeravechyan, Samaporn; Suphaphiphat, Pirada; Essex, Max; Lee, Tun-Hou

    2008-01-20

    A major difference between binding and fusion assays commonly used to study the human immunodeficiency virus (HIV) envelope is the use of monomeric envelope for the former assay and oligomeric envelope for the latter. Due to discrepancies in their readouts for some mutants, envelope regions involved in CCR5 coreceptor usage were systematically studied to determine whether the discordance is due to inherent differences between the two assays or whether it genuinely reflects functional differences at each entry step. By adding the binding inhibitor TAK-779 to delay coreceptor binding kinetics in the fusion assay, the readouts were found comparable between the assays for the mutants analysed in this study. Our finding indicates that monomeric binding reflects oligomeric envelope-CCR5 interaction, thus discordant results between binding and fusion assays do not necessarily indicate differences in coreceptor usage by oligomeric envelope and monomeric gp120.

  11. New recycling plant accepts and converts co-mingled plastic trash

    SciTech Connect (OSTI)

    Not Available

    1989-06-01

    The plant, owned and operated by Innovative Plastic Products Inc. (IPPI), uses a new patented German process to convert co-mingled plastic trash, including impurities like wood, papers, and metal, into a plastic alloy that is immediately molded into finished product. The products currently being produced by IPPI's facility in Greensboro, Ga., are: flat sheets in various thickness called InnoPlast GP(tm); a modular drainage trough called InnoDain(tm); pallets, dollies, industrial floor tile, and cable spools. Ken Carrier, vice president of Marketing, says that by year end the plant should reach an operating capacity of about 1 million pounds per month of finished product from the recycled plastic waste.

  12. Three-dimensional Structure of a Viral Genome-delivery Portal Vertex

    SciTech Connect (OSTI)

    A Olia; P Prevelige Jr.; J Johnson; G Cingolani

    2011-12-31

    DNA viruses such as bacteriophages and herpesviruses deliver their genome into and out of the capsid through large proteinaceous assemblies, known as portal proteins. Here, we report two snapshots of the dodecameric portal protein of bacteriophage P22. The 3.25-{angstrom}-resolution structure of the portal-protein core bound to 12 copies of gene product 4 (gp4) reveals a {approx}1.1-MDa assembly formed by 24 proteins. Unexpectedly, a lower-resolution structure of the full-length portal protein unveils the unique topology of the C-terminal domain, which forms a {approx}200-{angstrom}-long {alpha}-helical barrel. This domain inserts deeply into the virion and is highly conserved in the Podoviridae family. We propose that the barrel domain facilitates genome spooling onto the interior surface of the capsid during genome packaging and, in analogy to a rifle barrel, increases the accuracy of genome ejection into the host cell.

  13. Structural and magnetic phase transitions in gadolinium under high pressures and low temperatures

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Samudrala, Gopi K.; Tsoi, Georgiy M.; Weir, Samuel T.; Vohra, Yogesh K.

    2014-11-07

    High pressure structural transition studies have been carried out on rare earth metal gadolinium in a diamond anvil cell at room temperature to 169 GPa. Gadolinium has been compressed to 38% of its initial volume at this pressure. With increasing pressure, a crystal structure sequence of hcp → Smtype→ dhcp → fcc → dfcc → monoclinic has been observed in our studies on gadolinium. The measured equation of state of gadolinium is presented to 169 GPa at ambient temperature. Magnetic ordering temperature of gadolinium has been studied using designer diamond anvils to a pressure of 25 GP and a temperaturemore » of 10 K. The magnetic ordering temperature has been determined from the four-point electrical resistivity measurements carried out on gadolinium. Furthermore, our experiments show that the magnetic transition temperature decreases with increasing pressure to 19 GPa and then increases when gadolinium is subjected to higher pressures.« less

  14. Coordinated role of voltage-gated sodium channels and the Na{sup +}/H{sup +} exchanger in sustaining microglial activation during inflammation

    SciTech Connect (OSTI)

    Hossain, Muhammad M.; Sonsalla, Patricia K.; Richardson, Jason R.

    2013-12-01

    Persistent neuroinflammation and microglial activation play an integral role in the pathogenesis of many neurological disorders. We investigated the role of voltage-gated sodium channels (VGSC) and Na{sup +}/H{sup +} exchangers (NHE) in the activation of immortalized microglial cells (BV-2) after lipopolysaccharide (LPS) exposure. LPS (10 and 100 ng/ml) caused a dose- and time-dependent accumulation of intracellular sodium [(Na{sup +}){sub i}] in BV-2 cells. Pre-treatment of cells with the VGSC antagonist tetrodotoxin (TTX, 1 ?M) abolished short-term Na{sup +} influx, but was unable to prevent the accumulation of (Na{sup +}){sub i} observed at 6 and 24 h after LPS exposure. The NHE inhibitor cariporide (1 ?M) significantly reduced accumulation of (Na{sup +}){sub i} 6 and 24 h after LPS exposure. Furthermore, LPS increased the mRNA expression and protein level of NHE-1 in a dose- and time-dependent manner, which was significantly reduced after co-treatment with TTX and/or cariporide. LPS increased production of TNF-?, ROS, and H{sub 2}O{sub 2} and expression of gp91{sup phox}, an active subunit of NADPH oxidase, in a dose- and time-dependent manner, which was significantly reduced by TTX or TTX + cariporide. Collectively, these data demonstrate a closely-linked temporal relationship between VGSC and NHE-1 in regulating function in activated microglia, which may provide avenues for therapeutic interventions aimed at reducing neuroinflammation. - Highlights: LPS causes immediate increase in sodium through VGSC and subsequently through the NHE-1. Inhibition of VGSC reduces increases in NHE-1 and gp91{sup phox}. Inhibition of VGSC and NHE-1 reduces NADPH oxidase-mediated Tnf-?, ROS, and H{sub 2}O{sub 2} production. NHE-1 and Na{sub v}1.6 may be viable targets for therapeutic interventions to reduce neuroinflammation in neurodegenerative disease.

  15. Evaluation of the pharmacokinetics and cardiotoxicity of doxorubicin in rat receiving nilotinib

    SciTech Connect (OSTI)

    Zhou, Zhi-yong; Wan, Li-li; Yang, Quan-jun; Han, Yong-long; Li, Yan; Yu, Qi; Guo, Cheng; Li, Xiao

    2013-10-01

    Doxorubicin (DOX) is a potent chemotherapy drug with a narrow therapeutic window. Nilotinib, a small-molecule Bcr-Abl tyrosine kinase inhibitor, was reported to reverse multidrug resistance (MDR) mediated by P-glycoprotein (P-gp) transmembrane transporters. The present study aimed to investigate nilotinib's affection on the steady-state pharmacokinetics, disposition and cardiotoxicity of DOX. A total of 24 male SpragueDawley rats were randomized into four groups (6 in each) and received the following regimens: saline, intravenous DOX (5 mg/kg) alone, and DOX co-administrated with either 20 or 40 mg/kg nilotinib. Blood was withdrawn at 12 time points till 72 h after DOX injection and the concentrations of DOX and its metabolite doxorubicinol (DOXol) in serum and cardiac tissue were assayed by LCMSMS method. To determine the cardiotoxicity, the following parameters were investigated: creatine kinase, lactate dehydrogenase, malondialdehyde, and superoxide dismutase. Histopathological examination of heart section was carried out to evaluate the extent of cardiotoxicity after treatments. The results showed that pretreatment of 40 mg/kg nilotinib increased the AUC{sub 0t} and C{sub max} of DOX and DOXol. However, their accumulation in cardiac tissue was significantly decreased when compared with the group that received DOX alone. In addition, biochemical and histopathological results showed that 40 mg/kg nilotinib reduced the cardiotoxicity induced by DOX administration. In conclusion, co-administration of nilotinib increased serum exposure, but significantly decreased the accumulation of DOX in cardiac tissue. Consistent with in vitro profile, oral dose of 40 mg/kg nilotinib significantly decreased the cardiotoxicity of DOX in rat by enhancing P-gp activity in the heart.

  16. Fine precipitation scenarios of AlZnMg(Cu) alloys revealed by advanced atomic-resolution electron microscopy study Part II: Fine precipitation scenarios in AlZnMg(Cu) alloys

    SciTech Connect (OSTI)

    Liu, J.Z.; Chen, J.H.; Liu, Z.R.; Wu, C.L.

    2015-01-15

    Although they are among the most important precipitation-hardened materials for industry applications, the high-strength AlZnMg(Cu) alloys have thus far not yet been understood adequately about their underlying precipitation scenarios in relation with the properties. This is partly due to the fact that the structures of a number of different precipitates involved in the alloys are unknown, and partly due to the complexity that the precipitation behaviors of the alloys may be closely related to the alloy's composition. In Part I of the present study, we have determined all the unknown precipitate structures in the alloys. Here in Part II, using atomic-resolution electron microscopy in association with the first principles energy calculations, we further studied and correlated the phase/structure transformation/evolution among these hardening precipitates in relation with the alloy's composition. It is shown that there are actually two coexisting classes of hardening precipitates in these alloys: the first class includes the η′-precipitates and their early-stage Guinier–Preston (GP-η′) zones; the second class includes the precursors of the equilibrium η-phase (referred to η{sub p}, or η-precursor) and their early-stage Guinier–Preston (GP-η{sub p}) zones. The two coexisting classes of precipitates correspond to two precipitation scenarios. - Highlights: • We determine and verify all the key precipitate structures in AlMgZn(Cu) alloys. • We employ aberration-corrected scanning transmission electron microscopy (STEM). • We use aberration-corrected high-resolution TEM (HRTEM) for the investigations. • We obtain atomic-resolution images of the precipitates and model their structures. • We refine all precipitate structures with quantitative image simulation analysis. • The hardening precipitates in AlZnMg alloys shall be classified into two groups. • Two precipitation scenarios coexist in the alloys. • The precipitation behavior of such an alloy depends on the alloy's composition. • Very detailed phase/structure transformations among the precipitates are revealed.

  17. Neutrons measure phase behavior in pores at Angstrom size

    SciTech Connect (OSTI)

    Bardoel, Agatha A; Melnichenko, Yuri B

    2012-01-01

    Researchers have measured the phase behavior of green house gases in pores at the Angstrom-level, using small angle neutron scattering (SANS) at the Oak Ridge National Laboratory's High Flux Isotope Reactor. Yuri Melnichenko, an instrument scientist on the General Purpose Small Angle Neutron Scattering (GP SANS) Diffractometer at ORNL's High Flux Isotope Reactor, his postdoctoral associate Lilin He and collaborators Nidia Gallego and Cristian Contescu from the Material Sciences Division (ORNL) were engaged in the work. They were studying nanoporous carbons to assess their attractiveness as storage media for hydrogen, with a view to potential use for on-board hydrogen storage for transportation applications. Nanoporous carbons can also serve as electrode material for supercapacitors and batteries. The researchers successfully determined that the most efficiently condensing pore size in a carbon nanoporous material for hydrogen storage is less than one nanometer. In a paper recently published by the Journal of the American Chemical Society, the collaborators used small angle neutron scattering to study how hydrogen condenses in small pores at ambient temperature. They discovered that the surface-molecule interactions create internal pressures in pores that may exceed the external gas pressure by a factor of up to 50. 'This is an exciting result,' Melnichenko said, 'as you achieve extreme densification in pores 'for free', i.e. without spending any energy. These results can be used to guide the development of new carbon adsorbents tailored to maximize hydrogen storage capacities.' Another important factor that defines the adsorption capacity of sub-nanometer pores is their shape. In order to get accurate structural information and maximize sorption capacity, it is important that pores are small and of approximately uniform size. In collaboration with Drexel University's Yury Gogotsi who supplied the samples, Melnichenko and his collaborators used the GP SANS instrument to study how the size and shape of pores in sub-nanometer porous carbons varies, depending on the manufacturing conditions. While small angle X-ray scattering (SAXS) can do the job too, Melnichenko says, the SANS method broke new ground in analyzing the shape and behavior of pores at subnanometer size, when subjected to varying synthesis temperature. 'We found that these very small pores are in fact spherical, and that when we change the synthesis conditions, they become elongated, even 'slit-like', and all of this on a subnanometer scale,' Melnichenko said.

  18. The Citizen Cyberscience Lectures - 1) Mobile phones and Africa: a success story 2) Citizen Problem Solving

    SciTech Connect (OSTI)

    2009-10-28

    Mobile phones and Africa: a success story Dr. Mo Ibrahim, Mo Ibrahim Foundation Citizen Problem Solving Dr. Alpheus Bingham, InnoCentive The Citizen Cyberscience Lectures are hosted by the partners of the Citizen Cyberscience Centre, CERN, The UN Institute of Training and Research and the University of Geneva. The goal of the Lectures is to provide an inspirational forum for participants from the various international organizations and academic institutions in Geneva to explore how information technology is enabling greater citizen participation in tackling global development challenges as well as global scientific research. The first Citizen Cyberscience Lectures will welcome two speakers who have both made major innovative contributions in this area. Dr. Mo Ibrahim, founder of Celtel International, one of Africas most successful mobile network operators, will talk about Mobile phones and Africa: a success story. Dr. Alpheus Bingham, founder of InnoCentive, a Web-based community that solves industrial R&D; challenges, will discuss Citizen Problem Solving. The Citizen Cyberscience Lectures are open and free of charge. Participants from outside CERN must register by sending an email to Yasemin.Hauser@cern.ch BEFORE the 23rd october to be able to access CERN. THE LECTURES Mobile phones and Africa: a success story Dr. Mo Ibrahim, Mo Ibrahim Foundation Abstract The introduction of mobile phones into Africa changed the continent, enabling business and the commercial sector, creating directly and indirectly, millions of jobs. It enriched the social lives of many people. Surprisingly, it supported the emerging civil society and advanced the course of democracy Bio Dr Mo Ibrahim is a global expert in mobile communications with a distinguished academic and business career. In 1998, Dr Ibrahim founded Celtel International to build and operate mobile networks in Africa. Celtel became one of Africas most successful companies with operations in 15 countries, covering more than a third of the continents population and investing more than US$750 million in Africa. The company was sold to MTC Kuwait in 2005 for $3.4billion. In 2006 Dr Ibrahim established the Mo Ibrahim Foundation to support great African leadership. The Foundation focuses on two major initiatives to stimulate debate around, and improve the quality of, governance in Africa. The Ibrahim Prize for Achievement in African Leadership recognises and celebrates excellence; and the Ibrahim Index of African Governance provides civil society with a comprehensive and quantifiable tool to promote government accountability. Dr Ibrahim is also Founding Chairman of Satya Capital Ltd, an investment company focused on opportunities in Africa. Dr Ibrahim has been awarded an Honorary Doctorate by the University of Londons School of Oriental and African Studies, the University of Birmingham and De Montfort University, Leicester as well as an Honorary Fellowship Award from the London Business School. He has also received the Chairmans Award for Lifetime Achievement from the GSM Association in 2007 and the Economists Innovation Award 2007 for Social & Economic Innovation. In 2008 Dr Ibrahim was presented with the BNP Paribas Prize for Philanthropy, and also listed by TIME magazine as one of the 100 most influential people in the world. Citizen Problem Solving Dr. Alpheus Bingham, InnoCentive Abstract American playwright Damien Runyon (Guys and Dolls) once remarked, "the race is not always to the swift, nor the victory to the strong -- but that IS how you bet." Not only does a system of race handicapping follow from this logic, but the whole notion of expertise and technical qualifications. Such 'credentials' allow one to 'bet' on who might most likely solve a difficult challenge, whether as consultant, contractor or employee. Of course, the approach would differ if one were allowed to bet AFTER the race. When such systems came into broad use, i.e., chat rooms, usenets, innocentive, etc., and were subsequently studied, it was often found that the greate

  19. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan. Part 1 : ASC software quality engineering practices version 1.0.

    SciTech Connect (OSTI)

    Minana, Molly A.; Sturtevant, Judith E.; Heaphy, Robert; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Forsythe, Christi A.; Schofield, Joseph Richard, Jr.; Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2005-01-01

    The purpose of the Sandia National Laboratories (SNL) Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. Quality is defined in DOE/AL Quality Criteria (QC-1) as conformance to customer requirements and expectations. This quality plan defines the ASC program software quality practices and provides mappings of these practices to the SNL Corporate Process Requirements (CPR 1.3.2 and CPR 1.3.6) and the Department of Energy (DOE) document, ASCI Software Quality Engineering: Goals, Principles, and Guidelines (GP&G). This quality plan identifies ASC management and software project teams' responsibilities for cost-effective software engineering quality practices. The SNL ASC Software Quality Plan establishes the signatories commitment to improving software products by applying cost-effective software engineering quality practices. This document explains the project teams opportunities for tailoring and implementing the practices; enumerates the practices that compose the development of SNL ASC's software products; and includes a sample assessment checklist that was developed based upon the practices in this document.

  20. HIV-1 entry inhibition by small-molecule CCR5 antagonists: A combined molecular modeling and mutant study using a high-throughput assay

    SciTech Connect (OSTI)

    Labrecque, Jean; Metz, Markus; Lau, Gloria; Darkes, Marilyn C.; Wong, Rebecca S.Y.; Bogucki, David; Carpenter, Bryon; Chen Gang; Li Tongshuang; Nan, Susan; Schols, Dominique; Bridger, Gary J.; Fricker, Simon P.; Skerlj, Renato T.

    2011-05-10

    Based on the attrition rate of CCR5 small molecule antagonists in the clinic the discovery and development of next generation antagonists with an improved pharmacology and safety profile is necessary. Herein, we describe a combined molecular modeling, CCR5-mediated cell fusion, and receptor site-directed mutagenesis approach to study the molecular interactions of six structurally diverse compounds (aplaviroc, maraviroc, vicriviroc, TAK-779, SCH-C and a benzyloxycarbonyl-aminopiperidin-1-yl-butane derivative) with CCR5, a coreceptor for CCR5-tropic HIV-1 strains. This is the first study using an antifusogenic assay, a model of the interaction of the gp120 envelope protein with CCR5. This assay avoids the use of radioactivity and HIV infection assays, and can be used in a high throughput mode. The assay was validated by comparison with other established CCR5 assays. Given the hydrophobic nature of the binding pocket several binding models are suggested which could prove useful in the rational drug design of new lead compounds.

  1. Measurement of the Helicity Difference in γp→pπ+π- with the CLAS Spectrometer at Jefferson Laboratory

    SciTech Connect (OSTI)

    Park, Sungkyun

    2010-08-05

    The study of the properties of baryon resonances can provide us with hints to help us understand the structure of non-perturbative QCD and the effect of a particular resonance on polarization observables. The investigation of double-pion photoproduction data is needed to discover higher-lying states and their properties at and above W [approximate] 1.8 GeV. Therefore, the analysis of the helicity difference in gp γp→pπ+π- will help us in our understanding of QCD.The CLAS g9a (FROST) experiment, as part of the N* spectroscopy program at Jefferson Laboratory, has accumulated photoproduction data using linearly and circularly polarized photons incident on a longitudinally-polarized butanol target in the photon energy range 0.3 to 2.4 GeV. The FROST experiment provides an important step toward a “complete” experiment for the reaction gammaN-->KY.In this contribution, the method to calculate the helicity difference for the reaction γp→pπ+π- will be described and preliminary results will be discussed.

  2. Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zhu, Xiaojie; Zhu, Yun; Ye, Sheng; Wang, Qian; Xu, Wei; Su, Shan; Sun, Zhiwu; Yu, Fei; Liu, Qi; Wang, Chao; et al

    2015-08-19

    Enfuvirtide (T20), is the first HIV fusion inhibitor approved for treatment of HIV/AIDS patients who fail to respond to the current antiretroviral drugs. However, its clinical application is limited because of short half-life, drug resistance and cross-reactivity with the preexisting antibodies in HIV-infected patients. Using an artificial peptide strategy, we designed a peptide with non-native protein sequence, AP3, which exhibited potent antiviral activity against a broad spectrum of HIV-1 strains, including those resistant to T20, and had remarkably longer in vivo half-life than T20. While the preexisting antibodies in HIV-infected patients significantly suppressed T20’s antiviral activity, these antibodies neither recognizedmore » AP3, nor attenuated its anti-HIV-1 activity. Structurally different from T20, AP3 could fold into single-helix and interact with gp41 NHR. The two residues, Met and Thr, at the N-terminus of AP3 form a hook-like structure to stabilize interaction between AP3 and NHR helices. Therefore, AP3 has potential for further development as a new HIV fusion inhibitor with improved antiviral efficacy, resistance profile and pharmacological properties over enfuvirtide. Meanwhile, this study highlighted the advantages of artificially designed peptides, and confirmed that this strategy could be used in developing artificial peptide-based viral fusion inhibitors against HIV and other enveloped viruses.« less

  3. Final Technical Report

    SciTech Connect (OSTI)

    Alexander Fridman

    2005-06-01

    This DOE project DE-FC36-04GO14052 ''Plasma Pilot Plant Test for Treating VOC Emissions from Wood Products Plants'' was conducted by Drexel University in cooperation with Georgia-Pacific (G-P) and Kurchatov Institute (KI). The objective of this project was to test the Plasma Pilot Plant capabilities in wood industry. The final goal of the project was to replace the current state-of-the-art, regenerative thermal oxidation (RTO) technology by Low-Temperature Plasma Technology (LTPT) in paper and wood industry for Volatile Organic Components (VOC) destruction in High Volume Low Concentration (HVLC) vent emissions. MetPro Corporation joined the team as an industrial partner from the environmental control business and a potential leader for commercialization. Concurrent Technology Corporation (CTC) has a separate contract with DOE for this technology evaluation. They prepared questionnaires for comparison of this technology and RTO, and made this comparison. These data are presented in this report along with the description of the technology itself. Experiments with the pilot plant were performed with average plasma power up to 3.6 kW. Different design of the laboratory and pilot plant pulsed coronas, as well as different analytical methods revealed many new peculiarities of the VOC abatement process. The work reported herein describes the experimental results for the VOCs removal efficiency with respect to energy consumption, residence time, water effect and initial concentration.

  4. Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

    SciTech Connect (OSTI)

    Ferir, Geoffrey; Palmer, Kenneth E.; Schols, Dominique

    2011-09-01

    Griffithsin (GRFT) is possibly the most potent anti-HIV peptide found in natural sources. Due to its potent and broad-spectrum antiviral activity and unique safety profile it has great potential as topical microbicide component. Here, we evaluated various combinations of GRFT against HIV-1 clade B and clade C isolates in primary peripheral blood mononuclear cells (PBMCs) and in CD4{sup +} MT-4 cells. In all combinations tested, GRFT showed synergistic activity profile with tenofovir, maraviroc and enfuvirtide based on the median effect principle with combination indices (CI) varying between 0.34 and 0.79 at the calculated EC{sub 95} level. Furthermore, the different glycosylation patterns on the viral envelope of clade B and clade C gp120 had no observable effect on the synergistic interactions. Overall, we can conclude that the evaluated two-drug combination increases their antiviral potency and supports further clinical investigations in pre-exposure prophylaxis for GRFT combinations in the context of HIV-1 clade C infection.

  5. Nonparametric reconstruction of the dark energy equation of state

    SciTech Connect (OSTI)

    Heitmann, Katrin; Holsclaw, Tracy; Alam, Ujjaini; Habib, Salman; Higdon, David; Sanso, Bruno; Lee, Herbie

    2009-01-01

    The major aim of ongoing and upcoming cosmological surveys is to unravel the nature of dark energy. In the absence of a compelling theory to test, a natural approach is to first attempt to characterize the nature of dark energy in detail, the hope being that this will lead to clues about the underlying fundamental theory. A major target in this characterization is the determination of the dynamical properties of the dark energy equation of state w. The discovery of a time variation in w(z) could then lead to insights about the dynamical origin of dark energy. This approach requires a robust and bias-free method for reconstructing w(z) from data, which does not rely on restrictive expansion schemes or assumed functional forms for w(z). We present a new non parametric reconstruction method for the dark energy equation of state based on Gaussian Process models. This method reliably captures nontrivial behavior of w(z) and provides controlled error bounds. We demollstrate the power of the method on different sets of simulated supernova data. The GP model approach is very easily extended to include diverse cosmological probes.

  6. Initial precipitation and hardening mechanism during non-isothermal aging in an Al–Mg–Si–Cu 6005A alloy

    SciTech Connect (OSTI)

    Yang, Wenchao; Ji, Shouxun; Huang, Lanping; Sheng, Xiaofei; Li, Zhou; Wang, Mingpu

    2014-08-15

    The characterization of precipitation and hardening mechanism during non-isothermal aging had been investigated using high resolution transmission electron microscopy for an Al–Mg–Si–Cu 6005A alloy. It was proposed that the needle-shaped β″ precipitates with a three-dimension coherency strain-field and an increased number density in the Al matrix provided the maximum strengthening effect for the Al–Mg–Si–Cu 6005A alloy. Simultaneously, it was also found that the formation and evolution of clusters in the early precipitation were associated with the vacancy binding energy, during which Si atoms played an important role in controlling the numbers density of Mg/Si co-clusters, and the excess Si atoms provided the increased number of nucleation sites for the subsequent precipitates to strengthen and improve the precipitation rate. Finally, based on the experimental observation and theoretical analysis, the precipitation sequence during the early precipitation in the Al–Mg–Si–Cu 6005A alloy was proposed as: supersaturated solid solution → Si-vacancy pairs, Mg-vacancy pairs and Mg clusters → Si clusters, and dissolution of Mg clusters → Mg atoms diffusion into the existing Si clusters → Mg/Si co-clusters → GP zone. - Highlights: • β″ precipitates provide the maximum strengthening effect for the 6005A alloy. • Si atoms play an important role in controlling the numbers of Mg/Si co-clusters. • The early aging sequence is deduced based on the solute-vacancy binding energy.

  7. Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

    SciTech Connect (OSTI)

    Zhu, Xiaojie; Zhu, Yun; Ye, Sheng; Wang, Qian; Xu, Wei; Su, Shan; Sun, Zhiwu; Yu, Fei; Liu, Qi; Wang, Chao; Zhang, Tianhong; Zhang, Zhenqing; Zhang, Xiaoyan; Xu, Jianqing; Du, Lanying; Liu, Keliang; Lu, Lu; Zhang, Rongguang; Jiang, Shibo

    2015-08-19

    Enfuvirtide (T20), is the first HIV fusion inhibitor approved for treatment of HIV/AIDS patients who fail to respond to the current antiretroviral drugs. However, its clinical application is limited because of short half-life, drug resistance and cross-reactivity with the preexisting antibodies in HIV-infected patients. Using an artificial peptide strategy, we designed a peptide with non-native protein sequence, AP3, which exhibited potent antiviral activity against a broad spectrum of HIV-1 strains, including those resistant to T20, and had remarkably longer in vivo half-life than T20. While the preexisting antibodies in HIV-infected patients significantly suppressed T20’s antiviral activity, these antibodies neither recognized AP3, nor attenuated its anti-HIV-1 activity. Structurally different from T20, AP3 could fold into single-helix and interact with gp41 NHR. The two residues, Met and Thr, at the N-terminus of AP3 form a hook-like structure to stabilize interaction between AP3 and NHR helices. Therefore, AP3 has potential for further development as a new HIV fusion inhibitor with improved antiviral efficacy, resistance profile and pharmacological properties over enfuvirtide. Meanwhile, this study highlighted the advantages of artificially designed peptides, and confirmed that this strategy could be used in developing artificial peptide-based viral fusion inhibitors against HIV and other enveloped viruses.

  8. A comprehensive evaluation of various sensitivity analysis methods: A case study with a hydrological model

    SciTech Connect (OSTI)

    Gan, Yanjun; Duan, Qingyun; Gong, Wei; Tong, Charles; Sun, Yunwei; Chu, Wei; Ye, Aizhong; Miao, Chiyuan; Di, Zhenhua

    2014-01-01

    Sensitivity analysis (SA) is a commonly used approach for identifying important parameters that dominate model behaviors. We use a newly developed software package, a Problem Solving environment for Uncertainty Analysis and Design Exploration (PSUADE), to evaluate the effectiveness and efficiency of ten widely used SA methods, including seven qualitative and three quantitative ones. All SA methods are tested using a variety of sampling techniques to screen out the most sensitive (i.e., important) parameters from the insensitive ones. The Sacramento Soil Moisture Accounting (SAC-SMA) model, which has thirteen tunable parameters, is used for illustration. The South Branch Potomac River basin near Springfield, West Virginia in the U.S. is chosen as the study area. The key findings from this study are: (1) For qualitative SA methods, Correlation Analysis (CA), Regression Analysis (RA), and Gaussian Process (GP) screening methods are shown to be not effective in this example. Morris One-At-a-Time (MOAT) screening is the most efficient, needing only 280 samples to identify the most important parameters, but it is the least robust method. Multivariate Adaptive Regression Splines (MARS), Delta Test (DT) and Sum-Of-Trees (SOT) screening methods need about 400–600 samples for the same purpose. Monte Carlo (MC), Orthogonal Array (OA) and Orthogonal Array based Latin Hypercube (OALH) are appropriate sampling techniques for them; (2) For quantitative SA methods, at least 2777 samples are needed for Fourier Amplitude Sensitivity Test (FAST) to identity parameter main effect. McKay method needs about 360 samples to evaluate the main effect, more than 1000 samples to assess the two-way interaction effect. OALH and LPτ (LPTAU) sampling techniques are more appropriate for McKay method. For the Sobol' method, the minimum samples needed are 1050 to compute the first-order and total sensitivity indices correctly. These comparisons show that qualitative SA methods are more efficient but less accurate and robust than quantitative ones.

  9. Observations of giant pulses from pulsar B0950+08 using LWA1

    SciTech Connect (OSTI)

    Tsai, Jr-Wei; Simonetti, John H.; Bear, Brandon; Akukwe, Bernadine; Quezada, Leandro; Kavic, Michael; Cutchin, Sean E.; Dowell, Jayce; Schinzel, Frank K.; Taylor, Gregory B.; Gough, Jonathan D.; Kanner, Jonah; Kassim, Namir E.; Shawhan, Peter; Yancey, Cregg C.

    2015-02-01

    We report the detection of giant pulse (GP) emission from PSR B0950+08 in 24 hours of observations made at 39.4 MHz, with a bandwidth of 16 MHz, using the first station of the Long Wavelength Array. We detected 119 GPs from PSR B0950+08 (at its dispersion measure (DM)), which we define as having a signal-to-noise ratio at least 10 times larger than for the mean pulse in our data set. These 119 pulses are 0.035% of the total number of pulse periods in the 24 hours of observations. The rate of GPs is about 5.0 per hour. The cumulative distribution of pulse strength S is a steep power law, N(>S)?S{sup ?4.7}, but much less steep than would be expected if we were observing the tail of a Gaussian distribution of normal pulses. We detected no other transient pulses in a DM range from 1 to 90 pc cm{sup ?3}, in the beam tracking PSR B0950+08. The GPs have a narrower temporal width than the mean pulse (17.8 ms, on average, versus 30.5 ms). The pulse widths are consistent with a previously observed weak dependence on observing frequency, which may be indicative of a deviation from a Kolmogorov spectrum of electron density irregularities along the line of sight. The rate and strength of these GPs is less than has been observed at ?100 MHz. Additionally, the mean (normal) pulse flux density we observed is less than at ?100 MHz. These results suggest this pulsar is weaker and produces less frequent GPs at 39 MHz than at 100 MHz.

  10. Imaging findings and pharmacokinetics of 111-indium ZME-018 monoclonal antibody (MoAb) in malignant melanoma

    SciTech Connect (OSTI)

    Murray, J.L.; Rosenblum, M.; Lamki, L.; Haynie, T.P.; Glenn, H.; Jahns, M.; Plager, C.; Hersh, E.M.; Unger, M.; Carlo, D.L.

    1985-05-01

    13 patients with metastatic melanoma were studied using 5 mCi of In-111 labeled MoAb ZME-018 which reacts with GP 240 melanoma-associated antigen. The MoAb was infused over 2 h at doses of 2.5 mg (5 pts), 5 mg (5 pts), and 10 mg (3 pts). Total body tomograms and planar spot views with region of interest analysis were performed at 4, 24 and 72 hours post infusion. No adverse side effects were noted. There was rapid distribution to spleen, bone, bone marrow, liver, and testes. Tumor sites could be visualized as early as 24 hours but were more easily seen at 72 hours when the background activity was less. 20 of 46 (43%) previously documented metastases were identified. More sites imaged with increasing concentrations of MoAB, I.E., 25% at 2.5 mg; 67% at 5 mg; 70% at 10 mg. Tumor localization occurred in a significant number of patients especially at MoAb doses above 2.5 mg. In two instances, uptake of 111-In occurred in previously undiagnosed sites. The pharmacokinetics of MoAb were analyzed at each dose level. At the 5 mg dose, the terminal phase half-life for 111-In in plasma was 24.5 +- 2.7 hours. The apparent volume of distribution (Vd) was 4.03 +- 5iota similar to the plasma value, and the calculated clearance rate for 111-In label was 0.0259 + 0.002 ml/kg/min. Mean urinary excretion of 111-In label was 8.7 +- 0.6% of the administered dose over 48 hours after administration. The calculated pharmacokinetic parameters were independent of antibody dose. ZME 018 was cleared more rapidly from plasma, compared to previous studies with P97 antimelanoma MoAb.

  11. LINKING Lyα AND LOW-IONIZATION TRANSITIONS AT LOW OPTICAL DEPTH

    SciTech Connect (OSTI)

    Jaskot, A. E.; Oey, M. S.

    2014-08-20

    We suggest that low optical depth in the Lyman continuum (LyC) may relate the Lyα emission, C II and Si II absorption, and C II* and Si II* emission seen in high-redshift galaxies. We base this analysis on Hubble Space Telescope Cosmic Origins Spectrograph spectra of four Green Pea (GP) galaxies, which may be analogs of z > 2 Lyα emitters (LAEs). In the two GPs with the strongest Lyα emission, the Lyα line profiles show reduced signs of resonant scattering. Instead, the Lyα profiles resemble the Hα line profiles of evolved star ejecta, suggesting that the Lyα emission originates from a low column density and similar outflow geometry. The weak C II absorption and presence of non-resonant C II* emission in these GPs support this interpretation and imply a low LyC optical depth along the line of sight. In two additional GPs, weak Lyα emission and strong C II absorption suggest a higher optical depth. These two GPs differ in their Lyα profile shapes and C II* emission strengths, however, indicating different inclinations of the outflows to our line of sight. With these four GPs as examples, we explain the observed trends linking Lyα, C II, and C II* in stacked LAE spectra, in the context of optical depth and geometric effects. Specifically, in some galaxies with strong Lyα emission, a low LyC optical depth may allow Lyα to escape with reduced scattering. Furthermore, C II absorption, C II* emission, and Lyα profile shape can reveal the optical depth, constrain the orientation of neutral outflows in LAEs, and identify candidate LyC emitters.

  12. Benzene under high pressure: A story of molecular crystals transforming to saturated networks, with a possible intermediate metallic phase

    SciTech Connect (OSTI)

    Wen, Xiao-Dong; Hoffmann, Roald; Ashcroft, N. W.

    2011-01-01

    In a theoretical study, benzene is compressed up to 300 GPa. The transformations found between molecular phases generally match the experimental findings in the moderate pressure regime (<20 GPa): phase I (Pbca) is found to be stable up to 4 GPa, while phase II (P43212) is preferred in a narrow pressure range of 47 GPa. Phase III (P21/c) is at lowest enthalpy at higher pressures. Above 50 GPa, phase V (P21 at 0 GPa; P21/c at high pressure) comes into play, slightly more stable than phase III in the range of 5080 GP, but unstable to rearrangement to a saturated, four-coordinate (at C), one-dimensional polymer. Actually, throughout the entire pressure range, crystals of graphane possess lower enthalpy than molecular benzene structures; a simple thermochemical argument is given for why this is so. In several of the benzene phases there nevertheless are substantial barriers to rearranging the molecules to a saturated polymer, especially at low temperatures. Even at room temperature these barriers should allow one to study the effect of pressure on the metastable molecular phases. Molecular phase III (P21/c) is one such; it remains metastable to higher pressures up to ~200 GPa, at which point it too rearranges spontaneously to a saturated, tetracoordinate CH polymer. At 300 K the isomerization transition occurs at a lower pressure. Nevertheless, there may be a narrow region of pressure, between P = 180 and 200 GPa, where one could find a metallic, molecular benzene state. We explore several lower dimensional models for such a metallic benzene. We also probe the possible first steps in a localized, nucleated benzene polymerization by studying the dimerization of benzene molecules. Several new (C6H6)2 dimers are predicted.

  13. High-density genetic map of the BRCA1 region of chromosome 17q12-q21

    SciTech Connect (OSTI)

    Anderson, L.A.; Friedman, L.; Lynch, E.; King, M.C. ); Osborne-Lawrence, S.; Bowcock, A. ); Weissenbach, J. )

    1993-09-01

    To facilitate the positional cloning of the breast-ovarian cancer gene BRCA1, the authors constructed a high-density genetic map of the 8.3-cM interval between D17S250 and GIP on chromosome 17q12-q21. Markers were mapped by linkage in the CEPH and in extended kindreds in the breast cancer series. The map comprises 33 ordered polymorphisms, including 12 genes and 21 anonymous markers, yielding an average of one polymorphism every 250 kb. Twenty-five of the markers are PCR-based systems. The order of polymorphic genes and markers is cen-D17S250-D17S518-HER2-THRA1-RARA-D17S80-KRT10-[D17S800-D17S857]-GAS-D17S856-EDH17B-D17S855-D17S859-D17S858-[PPY-D17S78]-D17S183-EPB3-D17S579-D17S509-[D17S508-D17S190 = D17S810]-D17S791-[D17S181 = D17S806]-D17S797-HOX2B-GP3A-[D17S507 = GIP]-qter. BRCA1 lies in the middle of the interval, between THRA1 and D17S183. Markers from this map can be used to determine whether cancer is linked to BRCA1 in families, to evaluate whether tumors have lost heterozygosity at loci in the region, and to identify probes for characterizing chromosomal rearrangements from patients and from tumors. 21 refs., 1 fig., 3 tabs.

  14. Condition Based Monitoring of Gas Turbine Combustion Components

    SciTech Connect (OSTI)

    Ulerich, Nancy; Kidane, Getnet; Spiegelberg, Christine; Tevs, Nikolai

    2012-09-30

    The objective of this program is to develop sensors that allow condition based monitoring of critical combustion parts of gas turbines. Siemens teamed with innovative, small companies that were developing sensor concepts that could monitor wearing and cracking of hot turbine parts. A magnetic crack monitoring sensor concept developed by JENTEK Sensors, Inc. was evaluated in laboratory tests. Designs for engine application were evaluated. The inability to develop a robust lead wire to transmit the signal long distances resulted in a discontinuation of this concept. An optical wear sensor concept proposed by K Sciences GP, LLC was tested in proof-of concept testing. The sensor concept depended, however, on optical fiber tips wearing with the loaded part. The fiber tip wear resulted in too much optical input variability; the sensor could not provide adequate stability for measurement. Siemens developed an alternative optical wear sensor approach that used a commercial PHILTEC, Inc. optical gap sensor with an optical spacer to remove fibers from the wearing surface. The gap sensor measured the length of the wearing spacer to follow loaded part wear. This optical wear sensor was developed to a Technology Readiness Level (TRL) of 5. It was validated in lab tests and installed on a floating transition seal in an F-Class gas turbine. Laboratory tests indicate that the concept can measure wear on loaded parts at temperatures up to 800{degrees}C with uncertainty of < 0.3 mm. Testing in an F-Class engine installation showed that the optical spacer wore with the wearing part. The electro-optics box located outside the engine enclosure survived the engine enclosure environment. The fiber optic cable and the optical spacer, however, both degraded after about 100 operating hours, impacting the signal analysis.

  15. A comprehensive evaluation of various sensitivity analysis methods: A case study with a hydrological model

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Gan, Yanjun; Duan, Qingyun; Gong, Wei; Tong, Charles; Sun, Yunwei; Chu, Wei; Ye, Aizhong; Miao, Chiyuan; Di, Zhenhua

    2014-01-01

    Sensitivity analysis (SA) is a commonly used approach for identifying important parameters that dominate model behaviors. We use a newly developed software package, a Problem Solving environment for Uncertainty Analysis and Design Exploration (PSUADE), to evaluate the effectiveness and efficiency of ten widely used SA methods, including seven qualitative and three quantitative ones. All SA methods are tested using a variety of sampling techniques to screen out the most sensitive (i.e., important) parameters from the insensitive ones. The Sacramento Soil Moisture Accounting (SAC-SMA) model, which has thirteen tunable parameters, is used for illustration. The South Branch Potomac River basin nearmore » Springfield, West Virginia in the U.S. is chosen as the study area. The key findings from this study are: (1) For qualitative SA methods, Correlation Analysis (CA), Regression Analysis (RA), and Gaussian Process (GP) screening methods are shown to be not effective in this example. Morris One-At-a-Time (MOAT) screening is the most efficient, needing only 280 samples to identify the most important parameters, but it is the least robust method. Multivariate Adaptive Regression Splines (MARS), Delta Test (DT) and Sum-Of-Trees (SOT) screening methods need about 400–600 samples for the same purpose. Monte Carlo (MC), Orthogonal Array (OA) and Orthogonal Array based Latin Hypercube (OALH) are appropriate sampling techniques for them; (2) For quantitative SA methods, at least 2777 samples are needed for Fourier Amplitude Sensitivity Test (FAST) to identity parameter main effect. McKay method needs about 360 samples to evaluate the main effect, more than 1000 samples to assess the two-way interaction effect. OALH and LPτ (LPTAU) sampling techniques are more appropriate for McKay method. For the Sobol' method, the minimum samples needed are 1050 to compute the first-order and total sensitivity indices correctly. These comparisons show that qualitative SA methods are more efficient but less accurate and robust than quantitative ones.« less

  16. Comparison between lab- and full-scale applications of in situ aeration of an old landfill and assessment of long-term emission development after completion

    SciTech Connect (OSTI)

    Hrad, Marlies; Gamperling, Oliver; Huber-Humer, Marion

    2013-10-15

    Highlights: ? Current data on in situ aeration effects from the first Austrian full-scale case study. ? Data on lasting waste stabilisation after aeration completion. ? Information on the transferability of results from lab- to full-scale aeration. - Abstract: Sustainable landfilling has become a fundamental objective in many modern waste management concepts. In this context, the in situ aeration of landfills has been recognised for its potential to convert conventional anaerobic landfills into biological stabilised state, whereby both current and potential (long-term) emissions of the landfilled waste are mitigated. In recent years, different in situ aeration concepts have been successfully applied in Europe, North America and Asia, all pursuing different objectives and strategies. In Austria, the first full-scale application of in situ landfill aeration by means of low pressure air injection and simultaneous off-gas collection and treatment was implemented on an old, small municipal solid waste (MSW) landfill (2.6 ha) in autumn 2007. Complementary laboratory investigations were conducted with waste samples taken from the landfill site in order to provide more information on the transferability of the results from lab- to full-scale aeration measures. In addition, long-term emission development of the stabilised waste after aeration completion was assessed in an ongoing laboratory experiment. Although the initial waste material was described as mostly stable in terms of the biological parameters gas generation potential over 21 days (GP{sub 21}) and respiration activity over 4 days (RA{sub 4}), the lab-scale experiments indicated that aeration, which led to a significant improvement of leachate quality, was accompanied by further measurable changes in the solid waste material under optimised conditions. Even 75 weeks after aeration completion the leachate, as well as gaseous emissions from the stabilised waste material, remained low and stayed below the authorised Austrian discharge limits. However, the application of in situ aeration at the investigated landfill is a factor 10 behind the lab-based predictions after 3 years of operation, mainly due to technical limitations in the full-scale operation (e.g. high air flow resistivity due to high water content of waste and temporarily high water levels within the landfill; limited efficiency of the aeration wells). In addition, material preparation (e.g. sieving, sorting and homogenisation) prior to the emplacement in Landfill Simulation Reactors (LSRs) must be considered when transferring results from lab- to full-scale application.

  17. The Citizen Cyberscience Lectures - 1) Mobile phones and Africa: a success story 2) Citizen Problem Solving

    ScienceCinema (OSTI)

    None

    2011-10-06

    Mobile phones and Africa: a success story Dr. Mo Ibrahim, Mo Ibrahim Foundation Citizen Problem Solving Dr. Alpheus Bingham, InnoCentive The Citizen Cyberscience Lectures are hosted by the partners of the Citizen Cyberscience Centre, CERN, The UN Institute of Training and Research and the University of Geneva. The goal of the Lectures is to provide an inspirational forum for participants from the various international organizations and academic institutions in Geneva to explore how information technology is enabling greater citizen participation in tackling global development challenges as well as global scientific research. The first Citizen Cyberscience Lectures will welcome two speakers who have both made major innovative contributions in this area. Dr. Mo Ibrahim, founder of Celtel International, one of Africa?s most successful mobile network operators, will talk about ?Mobile phones and Africa: a success story?. Dr. Alpheus Bingham, founder of InnoCentive, a Web-based community that solves industrial R&D; challenges, will discuss ?Citizen Problem Solving?. The Citizen Cyberscience Lectures are open and free of charge. Participants from outside CERN must register by sending an email to Yasemin.Hauser@cern.ch BEFORE the 23rd october to be able to access CERN. THE LECTURES Mobile phones and Africa: a success story Dr. Mo Ibrahim, Mo Ibrahim Foundation Abstract The introduction of mobile phones into Africa changed the continent, enabling business and the commercial sector, creating directly and indirectly, millions of jobs. It enriched the social lives of many people. Surprisingly, it supported the emerging civil society and advanced the course of democracy Bio Dr Mo Ibrahim is a global expert in mobile communications with a distinguished academic and business career. In 1998, Dr Ibrahim founded Celtel International to build and operate mobile networks in Africa. Celtel became one of Africa?s most successful companies with operations in 15 countries, covering more than a third of the continent?s population and investing more than US$750 million in Africa. The company was sold to MTC Kuwait in 2005 for $3.4billion. In 2006 Dr Ibrahim established the Mo Ibrahim Foundation to support great African leadership. The Foundation focuses on two major initiatives to stimulate debate around, and improve the quality of, governance in Africa. The Ibrahim Prize for Achievement in African Leadership recognises and celebrates excellence; and the Ibrahim Index of African Governance provides civil society with a comprehensive and quantifiable tool to promote government accountability. Dr Ibrahim is also Founding Chairman of Satya Capital Ltd, an investment company focused on opportunities in Africa. Dr Ibrahim has been awarded an Honorary Doctorate by the University of London?s School of Oriental and African Studies, the University of Birmingham and De Montfort University, Leicester as well as an Honorary Fellowship Award from the London Business School. He has also received the Chairman?s Award for Lifetime Achievement from the GSM Association in 2007 and the Economists Innovation Award 2007 for Social & Economic Innovation. In 2008 Dr Ibrahim was presented with the BNP Paribas Prize for Philanthropy, and also listed by TIME magazine as one of the 100 most influential people in the world. Citizen Problem Solving Dr. Alpheus Bingham, InnoCentive Abstract American playwright Damien Runyon (Guys and Dolls) once remarked, "the race is not always to the swift, nor the victory to the strong -- but that IS how you bet." Not only does a system of race handicapping follow from this logic, but the whole notion of expertise and technical qualifications. Such 'credentials' allow one to 'bet' on who might most likely solve a difficult challenge, whether as consultant, contractor or employee. Of course, the approach would differ if one were allowed to bet AFTER the race. When such systems came into broad use, i.e., chat rooms, usenets, innocentive, etc., and were subsequently studied, it was often found that the greatest probability of solution lies in the "long tail" of the function rather than in the head representing formally vetted 'experts.' Insight into a problem is often the intersection of training, experience, metaphor and provocation (think Archimedes). Examples of "citizens" outside a targeted field of expertise providing uniques solutions will illustrate the principles involved. Bio Dr. Alph Bingham is a pioneer in the field of open innovation and an advocate of collaborative approaches to research and development. He is co-founder, and former president and chief executive officer of InnoCentive Inc., a Web-based community that matches companies facing R&D; challenges with scientists who propose solutions. Through InnoCentive, a platform that leverages the ability to connect to a whole planet of people through the Internet, organizations can access individuals ? problem solvers ? who might never have been found. Alph spent more than 25 years with Eli Lilly and Company, and offers deep experience in pharmaceutical research and development, research acquisitions and collaborations, and R&D; strategic planning. During his career he was instrumental in creating and developing Eli Lilly's portfolio management process as well as establishing the divisions of Research Acquisitions, the Office of Alliance Management and e.Lilly, a business innovation unit, from which various other ventures were spun out that create the advantages of open and networked organizational structures, including: InnoCentive, YourEncore, Inc., Coalesix, Inc., Maaguzi, Inc., Indigo Biosystems, Seriosity, Chorus and Collaborative Drug Discovery, Inc. He currently serves on the Board of Directors of InnoCentive, Inc., and Collaborative Drug Discovery, Inc.; the advisory boards of the Center for Collective Intelligence (MIT), and the Business Innovation Factory, as well as a member of the board of trustees of the Bankinter Foundation for Innovation in Madrid. He has lectured extensively at both national and international events and serves as a Visiting Scholar at the National Center for Supercomputing Application at the University of Illinois at Champaign-Urbana. He is also the former chairman of the Board of Editors of the Research Technology Management Journal. Dr. Bingham was the recipient of the Economist's Fourth Annual Innovation Summit "Business Process Award" for InnoCentive. He was also named as one of Project Management Institute's "Power 50" leaders in October 2005. Dr. Bingham received a Ph.D. in organic chemistry from Stanford University.

  18. RADIOACTIVE DEMONSTRATION OF FINAL MINERALIZED WASTE FORMS FOR HANFORD WASTE TREATMENT PLANT SECONDARY WASTE BY FLUIDIZED BED STEAM REFORMING USING THE BENCH SCALE REFORMER PLATFORM

    SciTech Connect (OSTI)

    Crawford, C.; Burket, P.; Cozzi, A.; Daniel, W.; Jantzen, C.; Missimer, D.

    2012-02-02

    The U.S. Department of Energy's Office of River Protection (ORP) is responsible for the retrieval, treatment, immobilization, and disposal of Hanford's tank waste. Currently there are approximately 56 million gallons of highly radioactive mixed wastes awaiting treatment. A key aspect of the River Protection Project (RPP) cleanup mission is to construct and operate the Waste Treatment and Immobilization Plant (WTP). The WTP will separate the tank waste into high-level and low-activity waste (LAW) fractions, both of which will subsequently be vitrified. The projected throughput capacity of the WTP LAW Vitrification Facility is insufficient to complete the RPP mission in the time frame required by the Hanford Federal Facility Agreement and Consent Order, also known as the Tri-Party Agreement (TPA), i.e. December 31, 2047. Therefore, Supplemental Treatment is required both to meet the TPA treatment requirements as well as to more cost effectively complete the tank waste treatment mission. In addition, the WTP LAW vitrification facility off-gas condensate known as WTP Secondary Waste (WTP-SW) will be generated and enriched in volatile components such as {sup 137}Cs, {sup 129}I, {sup 99}Tc, Cl, F, and SO{sub 4} that volatilize at the vitrification temperature of 1150 C in the absence of a continuous cold cap (that could minimize volatilization). The current waste disposal path for the WTP-SW is to process it through the Effluent Treatment Facility (ETF). Fluidized Bed Steam Reforming (FBSR) is being considered for immobilization of the ETF concentrate that would be generated by processing the WTP-SW. The focus of this current report is the WTP-SW. FBSR offers a moderate temperature (700-750 C) continuous method by which WTP-SW wastes can be processed irrespective of whether they contain organics, nitrates, sulfates/sulfides, chlorides, fluorides, volatile radionuclides or other aqueous components. The FBSR technology can process these wastes into a crystalline ceramic (mineral) waste form. The mineral waste form that is produced by co-processing waste with kaolin clay in an FBSR process has been shown to be as durable as LAW glass. Monolithing of the granular FBSR product is being investigated to prevent dispersion during transport or burial/storage, but is not necessary for performance. A Benchscale Steam Reformer (BSR) was designed and constructed at the SRNL to treat actual radioactive wastes to confirm the findings of the non-radioactive FBSR pilot scale tests and to qualify the waste form for applications at Hanford. BSR testing with WTP SW waste surrogates and associated analytical analyses and tests of granular products (GP) and monoliths began in the Fall of 2009, and then was continued from the Fall of 2010 through the Spring of 2011. Radioactive testing commenced in 2010 with a demonstration of Hanford's WTP-SW where Savannah River Site (SRS) High Level Waste (HLW) secondary waste from the Defense Waste Processing Facility (DWPF) was shimmed with a mixture of {sup 125/129}I and {sup 99}Tc to chemically resemble WTP-SW. Prior to these radioactive feed tests, non-radioactive simulants were also processed. Ninety six grams of radioactive granular product were made for testing and comparison to the non-radioactive pilot scale tests. The same mineral phases were found in the radioactive and non-radioactive testing.