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Sample records for ks il il

  1. IL

    Office of Legacy Management (LM)

    :; / 2. ' b-:-"y .",...4 * .-.a 2 IL !< :. 34 --' -, ' ' < I ,-. g Tvo"l r . . .-i- :- " .1-. . . . . NC0 /L ' J,, ' ;.' , -_I( + ? CENTRAL FILES c -&' { ' c;$y ;;j*' E ,J): ' i' Z, 1; p -^ r-raL-r.nuzT".Fn., , ,..-y - -' -ie .". iJ.&:~e!ct.;;' sf ' ;;i_is ,trip ' JG,' go f-Jj;~ey~ 2123 -:s<j .-&;.z ;y1y rrc&ed recr!p!~-,da.a .b ,&.j.,& .:*3;.. F-Y ' __ ,,,.x+; PC l;ealti: :.2,.i CCI ;et y. tirlr.&g t;1c oy-er at ion c.f sei;a~xl

  2. DOE - Office of Legacy Management -- Granite City IL Site - IL...

    Office of Legacy Management (LM)

    Contamination from rubbing off of oxidized uranium during handling. IL.28-3 IL.28-5 ... Aerial photograph of the Granite City, Illinois, Site IL.28-1 - DOE Memo; Wagoner to Price...

  3. IL FS Ecosmart Ltd | Open Energy Information

    Open Energy Info (EERE)

    Services Product: IL&FS Ecosmart Ltd., a subsidiary of the Infrastructure Leasing & Financial Services (IL&FS) Group, provides environmental services. References: IL&FS...

  4. AIR M A IL

    Office of Legacy Management (LM)

    MEMORlAL DRIVE AIR M A IL ._~ AtFx=b.-zf .7.-i- M r. s. .II. Gown -~ Gentlemen: Re: A.E.C. Contract No. We assume the weight of the 9-l/2" biscuits will:be 107'poutids approximately; i.e. 100 pounds of thorium per biscuit. A four biscuit charge is not feasible because of crucible dimensions, availability, etc. A three biscuit charge will, when molten, fill the proposed crucible half full. This condition is un- desirable because, due to the low heat of fusion of thorium and the

  5. Category:Chicago, IL | Open Energy Information

    Open Energy Info (EERE)

    74 KB SVHospital Chicago IL Commonwealth Edison Co.png SVHospital Chicago IL ... 68 KB SVLargeHotel Chicago IL Commonwealth Edison Co.png SVLargeHotel Chicago I... 75 KB...

  6. Category:Springfield, IL | Open Energy Information

    Open Energy Info (EERE)

    Springfield IL Commonwealth Edison Co.png SVQuickServiceRestaura... 75 KB SVFullServiceRestaurant Springfield IL Commonwealth Edison Co.png...

  7. Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex

    SciTech Connect (OSTI)

    Kennedy, M.K.; Park, L.S.

    1996-05-01

    IL-15 interacts with a heterotrimeric receptor that consists of the {beta} and {gamma} subunits of the IL-2 receptor (IL-2R) as well as a specific, high-affinity IL-15-binding subunit, which is designated IL-15R{alpha}. Since both the {beta} and the {gamma} subunits of the IL-2R are required for signaling by either IL-2 or IL-15, it is not surprising that these cytokines share many activities in vitro. However, the differential expression of these cytokines and the {alpha} chains of their receptors within various tissues and cell types suggests that IL-2 and IL-15 may perform at least partially distinct physiological functions. The production of IL-15 by macrophages, and possibly other cell types, in response to environmental stimuli and infectious agents suggests that IL-15 may play a role in protective immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. 56 refs.

  8. IL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power ...

  9. Il.-'",.'

    Office of Legacy Management (LM)

    ... D&D STATUS REPORT NEW BRUNSWICK LABORATORY NEW JERSEY SITE R. A. Wynveen V. R. Veluri W. H. Smith M. J. Robinet H. J. Moe DECEMBER 1981 INDEX Text D&D ......

  10. Structural and Biophysical Studies of the Human IL-7/IL-7R[alpha] Complex

    SciTech Connect (OSTI)

    McElroy, Craig A.; Dohm, Julie A.; Walsh, Scott T.R.; (OSU); (UPENN)

    2009-03-06

    IL-7 and IL-7R{alpha} bind the {gamma}{sub c} receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report that the IL-7R{alpha} ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the {gamma}{sub c} family. IL-7 binds glycosylated IL-7R{alpha} 300-fold more tightly than unglycosylated IL-7R{alpha}, and the enhanced affinity is attributed primarily to an accelerated on rate. Structural comparison of IL-7 in complex to both forms of IL-7R{alpha} reveals that glycosylation does not participate directly in the binding interface. The SCID mutations of IL-7R{alpha} locate outside the binding interface with IL-7, suggesting that the expressed mutations cause protein folding defects in IL-7R{alpha}. The IL-7/IL-7R{alpha} structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases.

  11. DOE - Office of Legacy Management -- Fansteel Metallurgical Corp - IL 16

    Office of Legacy Management (LM)

    Fansteel Metallurgical Corp - IL 16 FUSRAP Considered Sites Site: Fansteel Metallurgical Corp. (IL.16 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Chicago , Illinois IL.16-1 Evaluation Year: 1987 IL.16-3 Site Operations: Sole producer and supplier of tantalum and columbium metals to the MED. IL.16-1 IL.16-3 Site Disposition: Eliminated - No radioactive materials handled at this site IL.16-2 IL.16-3 Radioactive Materials

  12. DOE - Office of Legacy Management -- Kankakee Ordnance Plant - IL 32

    Office of Legacy Management (LM)

    Kankakee Ordnance Plant - IL 32 FUSRAP Considered Sites Site: KANKAKEE ORDNANCE PLANT (IL.32 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Kankakee , Illinois IL.32-1 Evaluation Year: 1991 IL.32-1 Site Operations: Kankakee Ordnance Plant was cited as a possible location for the disposal of radioactive waste material. There is no indication that any radioactive waste was brought to Kankakee. IL.32-1 IL.32-2 Site Disposition:

  13. DOE - Office of Legacy Management -- Swenson Evaporator Co - IL 23

    Office of Legacy Management (LM)

    Swenson Evaporator Co - IL 23 FUSRAP Considered Sites Site: SWENSON EVAPORATOR CO. (IL.23 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Harvey , Illinois IL.23-1 Evaluation Year: 1987 IL.23-1 Site Operations: Scheduled a raffinate spray drying test that was later cancelled. IL.23-1 Site Disposition: Eliminated - No indication that radioactive materials were handled at this site IL.23-1 Radioactive Materials Handled: None

  14. DOE - Office of Legacy Management -- Vapofier Corp - IL 25

    Office of Legacy Management (LM)

    Vapofier Corp - IL 25 FUSRAP Considered Sites Site: Vapofier Corp. (IL.25) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: Therm-A-Shield Co. IL.25-1 Location: 11957 Vincennes Avenue , Blue Island , Illinois IL.25-2 Evaluation Year: 1990 IL.25-1 Site Operations: Vapofier Corporation was a subcontractor to the MED during a nine month period in 1944. There is no indication that radioactive materials were handled. IL.25-1 Site Disposition:

  15. DOE - Office of Legacy Management -- Podbeilniac Corp - IL 22

    Office of Legacy Management (LM)

    Podbeilniac Corp - IL 22 FUSRAP Considered Sites Site: PODBEILNIAC CORP. (IL.22) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Chicago , Illinois IL.22-1 Evaluation Year: 1990 IL.22-2 Site Operations: MED used equipment for a uranium extraction experiment in 1957. IL.22-1 Site Disposition: Eliminated - Potential for contamination considered remote due to limited scope of activities performed at the site IL.22-2 IL.22-3 IL.22-4

  16. DOE - Office of Legacy Management -- Armour Research Foundation - IL 17

    Office of Legacy Management (LM)

    Research Foundation - IL 17 FUSRAP Considered Sites Site: Armour Research Foundation of the Illinois Institute of Technology (IL.17 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: Illinois Institute of Technology IL.17-1 Location: Technological Center, 10 West 35th Street , Chicago , Illinois IL.17-1 Evaluation Year: 1985 IL.17-3 Site Operations: Facility operated a research reactor and conducted associated research for the AEC beginning in

  17. DOE - Office of Legacy Management -- Blockson Chemical Co - IL 07

    Office of Legacy Management (LM)

    Blockson Chemical Co - IL 07 FUSRAP Considered Sites Site: Blockson Chemical Co. (IL.07) Eliminated from consideration under FUSRAP - Referred to US EPA Region V and the State of Illinios Designated Name: Not Designated Alternate Name: Olin Corporation IL.07-1 Location: Patterson Road , Joliet , Illinois IL.07-2 Evaluation Year: 1985 IL.07-1 Site Operations: Process development studies and pilot plant testing of uranium recovery from phosphoric acid during the 1950s. Site Disposition: Eliminated

  18. DOE - Office of Legacy Management -- Kaiser Aluminum Corp - IL 19

    Office of Legacy Management (LM)

    Kaiser Aluminum Corp - IL 19 FUSRAP Considered Sites Site: KAISER ALUMINUM CORP. (IL.19 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Dolton , Illinois IL.19-2 Evaluation Year: 1987 IL.19-2 Site Operations: Performed limited duration work extruding uranium billets into three CP-5 fuel elements, circa 1959. IL.19-2 Site Disposition: Eliminated - Potential for contamination considered remote due to limited scope of activities

  19. DOE - Office of Legacy Management -- Precision Extrusion Co - IL 20

    Office of Legacy Management (LM)

    Precision Extrusion Co - IL 20 FUSRAP Considered Sites Site: PRECISION EXTRUSION CO. (IL.20) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 720 East Green Avenue , Bensenville , Illinois IL.20-1 Evaluation Year: 1987 IL.20-2 Site Operations: 1956-1959, metal fabrication - extruded uranium billets. IL.20-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited quantities of materials handled

  20. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

    SciTech Connect (OSTI)

    Forward, Nicholas A.; Conrad, David M.; Power Coombs, Melanie R.; Doucette, Carolyn D.; Furlong, Suzanne J.; Lin, Tong-Jun; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia ; Hoskin, David W.

    2011-04-22

    Highlights: {yields} Curcumin inhibits CD4{sup +} T-lymphocyte proliferation. {yields} Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4{sup +} T-lymphocytes. {yields} Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. {yields} IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin. -- Abstract: Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4{sup +} T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 ({alpha} chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28. Curcumin acted downstream of protein kinase C activation and intracellular Ca{sup 2+} release to inhibit I{kappa}B phosphorylation, which is required for nuclear translocation of the transcription factor NF{kappa}B. In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling. IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling. In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4{sup +}CD25{sup +} regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression. We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.

  1. DOE - Office of Legacy Management -- Heavy Minerals Inc - IL 14

    Office of Legacy Management (LM)

    Heavy Minerals Inc - IL 14 FUSRAP Considered Sites Site: Heavy Minerals, Inc. ( IL.14 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: W.R. Grace Company IL.14-1 Location: 836 South Michigan Avenue , Chicago , Illinois IL.14-2 Evaluation Year: 1990 IL.14-1 Site Operations: Submitted a proposal to supply thorium hydroxide to the AEC; no indication that the bid was accepted. IL.14-2 Site Disposition: Eliminated - No indication of work done with

  2. DOE - Office of Legacy Management -- Chicago North IL Site -...

    Office of Legacy Management (LM)

    IL.05-1 - DOE Letter; Whitman to Wallo; Subject: Authority decisions regarding several sites; October 28, 1985 IL.05-2 - DOE Letter; DeLaney to Holesinger; Subject: Radiological ...

  3. DOE - Office of Legacy Management -- Rock Island Arsenal - IL...

    Office of Legacy Management (LM)

    to DOD Designated Name: Not Designated Alternate Name: None Location: Rock Island , Illinois IL.09-1 Evaluation Year: 1987 IL.09-2 Site Operations: Site located on a DOD ...

  4. Il Woong Jung | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Il Woong Jung Assistant Scientist Education Ph.D., Electrical Engineering, Stanford University Research Summary Research interests are in photonic applications for micro- and nano-mechanical devices. Current research focuses on the manipulation of light-matter interaction at the nanoscale, specifically using micro- and nano-mechanical devices to control the optical properties of photonic nanostructures. The aim is to integrate optical nanostructures and nanomechanical devices to create novel

  5. DOE - Office of Legacy Management -- International Register - IL 15

    Office of Legacy Management (LM)

    Register - IL 15 Site ID (CSD Index Number): IL.15 Site Name: International Register Site Summary: Site Link: External Site Link: Alternate Name(s): Intermatic Inc. Alternate Name Documents: Location: Chicago, Illinois Location Documents: IL.15-1 Historical Operations (describe contaminants): Limited testing of centerless grinding techniques for uranium metal for the AEC. Historical Operations Documents: IL.15-2 Eligibility Determination: Eliminated - Potential for contamination considered

  6. DOE - Office of Legacy Management -- Crane Co - IL 13

    Office of Legacy Management (LM)

    Crane Co - IL 13 FUSRAP Considered Sites Site: Crane Co. (IL.13 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Chicago , Illinois IL.13-2 Evaluation Year: 1987 IL.13-2 Site Operations: MED activities during late-1940s to early/mid-1950s included the development of valves and possibly the use of test quantities of normal uranium in the development process. IL.13-4 Site Disposition: Eliminated - Potential for contamination remote due to

  7. DOE - Office of Legacy Management -- GSA 39th Street Warehouse - IL 02

    Office of Legacy Management (LM)

    GSA 39th Street Warehouse - IL 02 FUSRAP Considered Sites Site: GSA 39TH STREET WAREHOUSE (IL.02 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 1716 West Pershing Road , Chicago , Illinois IL.02-1 Evaluation Year: 1985 IL.02-2 IL.02-3 Site Operations: Stored radioactive materials. IL.02-1 IL.02-2 Site Disposition: Eliminated - Radiation levels below criteria IL.02-1 Radioactive Materials Handled: Yes Primary Radioactive Materials

  8. DOE - Office of Legacy Management -- Madison - IL 26

    Office of Legacy Management (LM)

    Historical Operations: Conducted experimental work in natural uranium metal extrusion. ... 1992 IL.26-2 - DOE Memorandum; Wagoner to Price (OR); Authorization for Remedial Action at ...

  9. DOE - Office of Legacy Management -- American Machine and Metals Inc - IL

    Office of Legacy Management (LM)

    24 Metals Inc - IL 24 FUSRAP Considered Sites Site: American Machine and Metals Inc (IL.24 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: E. Moline , Illinois IL.24-1 Evaluation Year: 1994 IL.24-2 IL.24-3 Site Operations: Tested process for dewatering green salt by centrifugation. IL.24-1 IL.24-2 Site Disposition: Eliminated - Potential for contamination considered remote due to limited amount of radioactive materials handled

  10. DOE - Office of Legacy Management -- Lindsay Light and Chemical Co - IL 10

    Office of Legacy Management (LM)

    Lindsay Light and Chemical Co - IL 10 FUSRAP Considered Sites Site: LINDSAY LIGHT AND CHEMICAL CO. ( IL.10 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: West Chicago , Illinois IL.10-3 Evaluation Year: 1995 IL.10-4 Site Operations: Processed thorium ores - chiefly monazite sands - for thorium and rare earth metals. IL.10-1 IL.10-2 Site Disposition: Eliminated - No Authority - NRC licensed operation IL.10-4 Radioactive Materials

  11. DOE - Office of Legacy Management -- W E Pratt Manufacturing Co - IL 12

    Office of Legacy Management (LM)

    E Pratt Manufacturing Co - IL 12 FUSRAP Considered Sites Site: W.E. PRATT MANUFACTURING CO. (IL.12) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: William E. Pratt Manufacturing Co. Klassing Handbrake Company IL.12-1 IL.12-2 Location: 18 Henderson Street , Joliet , Illinois IL.12-3 Evaluation Year: 1990 IL.12-4 IL.12-5 Site Operations: Performed metal fabrication tasks (machining and grinding). IL.12-1 IL.12-4 Site Disposition: Eliminated - Radiation

  12. Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation

    SciTech Connect (OSTI)

    Zuniga-Pfluecker, J.C.K.; Kruisbeek, A.M. )

    1990-05-15

    Sublethally irradiated mice undergo thymic regeneration which follows a phenotypic pattern of events similar to that observed during normal fetal development. Thymic regeneration after irradiation is the product of a limited pool of intrathymic radioresistant stem cells undergoing simultaneous differentiation. We show that in this model of T cell development, thymic regeneration follows a pathway in which the IL-2R is transiently expressed on CD4-/CD8- cells. IL-2R expression occurred during the exponential growth period of thymic regeneration, and IL-2R blocking prevented this explosive growth. Flow cytometry analysis revealed that the IL-2R blockade affected primarily the development of the immature CD3-/CD4-/CD8- (triple negative) cells and their ability to generate CD3+/CD4+/CD8+ or CD3+/CD4+/CD8- and CD3+/CD4-/CD8+ thymocytes. Thus, our findings demonstrate that blocking of the IL-2R resulted in an arrest in proliferation and differentiation by intrathymic radioresistant stem cells, indicating that the IL-2/IL-2R pathway is necessary for the expansion of immature triple negative T cells.

  13. DOE - Office of Legacy Management -- Great Lakes Carbon Corp - IL 21

    Office of Legacy Management (LM)

    Great Lakes Carbon Corp - IL 21 FUSRAP Considered Sites Site: GREAT LAKES CARBON CORP. ( IL.21 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 333 North Michigan Avenue , Chicago , Illinois IL.21-1 Evaluation Year: 1987 IL.21-1 Site Operations: Facility performed a limited amount of nuclear fuel fabrication in the 1950s. Facility also developed graphite production under an AEC contract. IL.21-1 IL.21-3 Site Disposition:

  14. DOE - Office of Legacy Management -- Chicago South IL Site -...

    Office of Legacy Management (LM)

    This site is managed by the U.S. Department of Energy Office of Legacy Management. IL.06-1 - DOE Memorandum; Coffman to LaGrone; Subject: Designation of the University of Chicago ...

  15. Origin State>> CA ID ID IL IL KY NM NM NV NY OH TN TN TN, WA,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    IL IL KY NM NM NV NY OH TN TN TN, WA, CA TN TN TN TN Total Shipments by Route Lawrence Livermore National Laboratory Batelle Energy Alliance Idaho National Laboratory Energx Argonne National Laboratory Argonne National Laboratory Paducah Gaseous Diffusion Plant Sandia National Laboratory Los Alamos National Laboratory National Security Technologies West Valley Environmental Services Portsmouth Gaseous Diffusion Plant Duratek/Energy Solutions Babcox & Wilcox Technical Services Y-12 Plant

  16. Interleukin-2 (IL-2) dependent expression of biologically relevant IL-2 receptors: uncoupling of anti-T3 induced receptor expression with cyclosporin

    SciTech Connect (OSTI)

    Gitter, A.B.D.; Labus, J.M.; Butler, L.D.

    1986-03-01

    Human peripheral blood T cell expression of IL-2 receptors (IL-2R), detected by both immunocytofluorometry and /sup 125/I-IL-2 binding, was studied using lymphocytes stimulated with monoclonal anti-T3 antibodies (Leu-4, OKT3). Lymphocytes, isolated from healthy individuals, were prescreened and classified as Leu-4 responders or non-responders according to 72 h /sup 3/H-thymidine incorporation experiments. Leu-4 non-responder lymphocytes, though capable of normal IL-2R expression and IL-2 secretion when cultured with OKT3 (IgG2a), expressed little to no IL-2R nor secreted IL-2 when stimulated with Leu-4 (IgG1). In addition, the amount of IL-2 secreted by Leu-4 stimulated, Leu-4 responder cells, was one-third- to one-fifth of that detected when OKT3 was used as the stimulant. The addition of recombinant IL-2 (rIL-2) to a Leu-4 stimulated, Leu-4 non-responder lymphocyte culture, resulted in the expression of IL-2R and cellular proliferation, indicating that IL-2 upregulated its biologically relevant receptor. As expected, cyclosporin-A (CSA) inhibited the secretion of IL-2 and subsequent proliferation of Leu-4 stimulated, Leu-4 responder cells. Unexpectedly, however, the expression of IL-2R was also blocked. Exogenous rIL-2 partially reversed the effect of CSA on IL-2R expression and proliferation. The results indicate that IL-2 may provide an additional, required signal for optimal IL-2R expression.

  17. DOE - Office of Legacy Management -- Quality Hardware and Machine Co - IL

    Office of Legacy Management (LM)

    11 Quality Hardware and Machine Co - IL 11 FUSRAP Considered Sites Site: QUALITY HARDWARE AND MACHINE CO. (IL.11) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Ravenswood Venture Marden Manufacturing Co. IL.11-1 IL.11-2 Location: 5823/5849 North Ravenswood Avenue , Chicago , Illinois IL.11-3 Evaluation Year: 1990 IL.11-4 IL.11-5 Site Operations: From 1944 to 1945, entered into subcontracts with the University of Chicago to furnish personnel,

  18. DOE - Office of Legacy Management -- C-B Tool Products Co - IL 31

    Office of Legacy Management (LM)

    C-B Tool Products Co - IL 31 FUSRAP Considered Sites Site: C-B Tool Products Co. (IL.31 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 956 East 58th Street , Chicago , Illinois IL.31-1 Evaluation Year: 1990 IL.31-2 Site Operations: Provided personnel, facilities, and equipment to produce special machining of parts for special equipment from materials furnished by the University. IL.31-4 Site Disposition: Eliminated - Potential for

  19. DOE - Office of Legacy Management -- Era Tool and Engineering Co - IL 29

    Office of Legacy Management (LM)

    Era Tool and Engineering Co - IL 29 FUSRAP Considered Sites Site: Era Tool and Engineering Co. (IL.29 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Audi-Tex Industries, Incorporated IL.29-1 Location: 4555 West Addison Street , Chicago , Illinois IL.29-2 Evaluation Year: 1989 IL.29-3 Site Operations: From February 1944 through June 1944, provided personnel, facilities, and equipment to produce machined parts for special equipment, tools, jigs,

  20. DOE - Office of Legacy Management -- Max Zuckerman and Sons - IL 30

    Office of Legacy Management (LM)

    - IL 30 FUSRAP Considered Sites Site: MAX ZUCKERMAN & SONS (IL.30 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 1925 N. Kenmore Avenue , Chicago , Illinois IL.30-1 Evaluation Year: 1994 IL.30-2 Site Operations: Sample sized quantities of radioactive materials were shipped through this location; broker arranged purchases of materials for third party buyers. IL.30-2 Site Disposition: Eliminated - Potential for contamination

  1. DOE - Office of Legacy Management -- Museum of Science and Industry - IL 03

    Office of Legacy Management (LM)

    Museum of Science and Industry - IL 03 FUSRAP Considered Sites Site: MUSEUM OF SCIENCE AND INDUSTRY ( IL.03 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 57th Street and Lake Shore Drive , Chicago , Illinois IL.03-1 Evaluation Year: 1985 IL.03-2 IL.03-3 Site Operations: The Metallurgical Laboratory and Argonne National Laboratory occupied space in the Museum of Science and Industry from August 15, 1946 to July 15, 1953. Some handling

  2. Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells

    SciTech Connect (OSTI)

    Kamide, Yosuke; Ishizuka, Tamotsu; Tobo, Masayuki; Tsurumaki, Hiroaki; Aoki, Haruka; Mogi, Chihiro; Nakakura, Takashi; Yatomi, Masakiyo; Ono, Akihiro; Koga, Yasuhiko; Sato, Koichi; Hisada, Takeshi; Dobashi, Kunio; Yamada, Masanobu; Okajima, Fumikazu

    2015-08-28

    Although blood pH is maintained in a narrow range of around pH 7.4 in living organisms, inflammatory loci are characterized by acidic conditions. Mast cells tend to reside close to the surface of the body in areas such as the mucosa and skin where they may be exposed to exogenous acids, and they play an important role in immune responses. However, little is known about the effects of extracellular acidification on the functions of mast cell. Here, we found that extracellular acidification increased the dinitrophenyl-conjugated human serum albumin (DNP-HSA)-induced production of interleukin (IL)-6 and IL-13 in MC/9 cells or bone marrow-derived mouse mast cells sensitized with anti-DNP IgE. Extracellular acidification also inhibited migration of MC/9 cells toward DNP-HSA. In addition, acidic pH stimulated antigen-induced activation of p38 mitogen-activated protein kinase (MAPK) and protein kinase B (Akt). These findings suggest that extracellular acidification augmented antigen/IgE-induced and FcεRI-mediated production of IL-6 and IL-13 in mast cells, and that this was associated with the enhancement of p38 MAPK and Akt activation. - Highlights: • Antigen-induced IL-6 and IL-13 production was augmented by acidic pH in mast cells. • Acidic pH-induced actions were associated with activation of p38 MAPK and Akt. • Inhibition of p38 MAPK and Akt attenuated cytokine responses to acidic pH. • Acidic pH effects are not attributable to actions of known proton-sensing GPCRs.

  3. DOE - Office of Legacy Management -- Eimco Corp - IL 0-01

    Office of Legacy Management (LM)

    Eimco Corp - IL 0-01 FUSRAP Considered Sites Site: Eimco Corp. (IL.0-01 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Palatine , Illinois IL.0-01-1 Evaluation Year: 1987 IL.0-01-1 Site Operations: Conducted laboratory leaf filtration tests IL.0-01-1 Site Disposition: Eliminated - Potential for contamination considered remote based on the limited scope of activities at the site IL.0-01-1 Radioactive Materials Handled: Yes Primary

  4. DOE - Office of Legacy Management -- Granite City Army Depot - IL 0-02

    Office of Legacy Management (LM)

    Granite City Army Depot - IL 0-02 FUSRAP Considered Sites Site: GRANITE CITY ARMY DEPOT ( IL.0-02 ) Eliminated from consideration under FUSRAP - Referred to DOD Designated Name: Not Designated Alternate Name: None Location: Granite City , Illinois IL.0-02-1 Evaluation Year: 1987 IL.0-02-1 Site Operations: Site was used for storage of GSA thorium residues until circa 1964. IL.0-02-1 Site Disposition: Eliminated - Referred to DOD IL.0-02-1 Radioactive Materials Handled: Yes Primary Radioactive

  5. DOE - Office of Legacy Management -- Midwest Manufacturing Co - IL 0-04

    Office of Legacy Management (LM)

    Midwest Manufacturing Co - IL 0-04 FUSRAP Considered Sites Site: MIDWEST MANUFACTURING CO (IL.0-04 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Evaluation Year: 1987 IL.0-04-3 Site Operations: Research and development on deep drawing of sheet metal in the mid- 1940s. IL.0-04-3 Site Disposition: Site Disposition IL.0-04-1 IL.0-04-3 Radioactive Materials Handled: None Indicated Primary Radioactive Materials Handled: None Indicated

  6. DOE - Office of Legacy Management -- Sciaky Brothers Inc - IL 0-06

    Office of Legacy Management (LM)

    Sciaky Brothers Inc - IL 0-06 FUSRAP Considered Sites Site: SCIAKY BROTHERS, INC (IL.0-06 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 4915 West 67th Street , Chicago , Illinois IL.0-06-1 Evaluation Year: 1987 IL.0-06-2 Site Operations: One time operation involving stitch welding of uranium in 1953. IL.0-06-1 IL.0-06-2 Site Disposition: Eliminated - Potential for contamination considered remote based on limited operations at the site

  7. DOE - Office of Legacy Management -- Morse Chemical Co - IL 0-05

    Office of Legacy Management (LM)

    Morse Chemical Co - IL 0-05 FUSRAP Considered Sites Site: MORSE CHEMICAL CO. (IL.0-05 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 8 South Michigan Avenue , Chicago , Illinois IL.05-1 Evaluation Year: 1987 IL.05-3 Site Operations: Submitted a bid to AEC for thorium work; proposal was not accepted; no indication work done for a DOE predecessor at this site. IL.05-3 Site Disposition: Eliminated - No Authority - No work for a DOE

  8. #iWNCD W ONTAININO Il@MQWm;

    Office of Legacy Management (LM)

    decontmlmtlon proceam takee longer than originally anticipated 'U&e order .are urgently required to prevent a shutdown. "Z, mo-1 ' 2lda.p - from 4a6-55 to a possible 4-5-55 based on the receipt of vendor's plantby 1-22-55. #iWNCD W ONTAININO Il@MQWm; ;g hours worked; Hours worked will be observed and under the control of . . M%-.'E.Section . (Copy of Vendorts letter of quotation dated l/5/55 is VAWNWWXlINALORDEt :Y $ u(,507.60 upoDRpuiI9APPROPAk &movND* 0 3375.00 (rllaxlmum) Field

  9. Association study of schizophrenia and IL-2 receptor {beta} chain gene

    SciTech Connect (OSTI)

    Nimgaonkar, V.L.; Yang, Z.W.; Zhang, X.R.; Brar, J.S.

    1995-10-09

    A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2RP chain gene, were examined in both groups. No significant differences in IL-2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2RP gene locus, contrary to the suggestive evidence from linkage analysis in multicase families. 17 refs., 2 tabs.

  10. ENVIRONMENTAL IlONITORING REPORT FOR THE NEVADA TEST SITE AND...

    Office of Legacy Management (LM)

    IlONITORING REPORT FOR THE NEVADA TEST SITE AND OTHER TEST AREAS USED FOR UNDERGROUND NUCLEAR DETONATIONS January through December 1975 Nonitoring Operations Division Environmental ...

  11. Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction

    SciTech Connect (OSTI)

    Fujii, Hodaka . E-mail: hodaka@med.nyu.edu

    2007-03-16

    Binding of interleukin-2 (IL-2) to its specific receptor induces activation of two members of Jak family protein tyrosine kinases, Jak1 and Jak3. An IL-2 receptor (IL-2R)-reconstituted NIH 3T3 fibroblast cell line proliferates in response to IL-2 only when hematopoietic lineage-specific Jak3 is ectopically expressed. However, the mechanism of Jak3-dependent proliferation in the fibroblast cell line is not known. Here, I showed that Jak3 expression is dispensable for IL-2-induced activation of Jak1 and Stat proteins and expression of nuclear proto-oncogenes in the IL-2R-reconstituted fibroblast cell line. Jak3 expression markedly enhanced these IL-2-induced signaling events. In contrast, Jak3 expression was essential for induction of cyclin genes involved in the G1-S transition. These data suggest a critical role of Jak3 in IL-2 signaling in the fibroblast cell line and may provide further insight into the cell type-specific mechanism of cytokine signaling.

  12. Irreversible inhibition of RANK expression as a possible mechanism for IL-3 inhibition of RANKL-induced osteoclastogenesis

    SciTech Connect (OSTI)

    Khapli, Shruti M.; Tomar, Geetanjali B.; Barhanpurkar, Amruta P.; Gupta, Navita; Yogesha, S.D.; Pote, Satish T.; Wani, Mohan R.

    2010-09-03

    Research highlights: {yields} IL-3 inhibits receptor activator of NF-{kappa}B ligand (RANKL)-induced osteoclastogenesis. {yields} IL-3 inhibits RANKL-induced JNK activation. {yields} IL-3 down-regulates expression of c-Fos and NFATc1 transcription factors. {yields} IL-3 down-regulates RANK expression posttranscriptionally and irreversibly. {yields} IL-3 inhibits in vivo RANK expression. -- Abstract: IL-3, a cytokine secreted by activated T lymphocytes, stimulates the proliferation, differentiation and survival of pluripotent hematopoietic stem cells. In this study, we investigated the mechanism of inhibitory action of IL-3 on osteoclast differentiation. We show here that IL-3 significantly inhibits receptor activator of NF-{kappa}B (RANK) ligand (RANKL)-induced activation of c-Jun N-terminal kinase (JNK). IL-3 down-regulates expression of c-Fos and nuclear factor of activated T cells (NFATc1) transcription factors. In addition, IL-3 down-regulates RANK expression posttranscriptionally in both purified osteoclast precursors and whole bone marrow cells. Furthermore, the inhibitory effect of IL-3 on RANK expression was irreversible. Interestingly, IL-3 inhibits in vivo RANK expression in mice. Thus, we provide the first evidence that IL-3 irreversibly inhibits RANK expression that results in inhibition of important signaling molecules induced by RANKL.

  13. File:USDA-CE-Production-GIFmaps-IL.pdf | Open Energy Information

    Open Energy Info (EERE)

    IL.pdf Jump to: navigation, search File File history File usage Illinois Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  14. DOE - Office of Legacy Management -- Hydroblast Corp - IL 0-03

    Office of Legacy Management (LM)

    FUSRAP Also see Documents Related to HYDROBLAST CORP. IL.0-03-1 - AEC Memorandum; Smith to Malone; Subject: Shipment of Bethlehem Rods, Reference NYC-504; June 22, 1951 ...

  15. IL-33 inhibits RANKL-induced osteoclast formation through the regulation of Blimp-1 and IRF-8 expression

    SciTech Connect (OSTI)

    Kiyomiya, Hiroyasu; Ariyoshi, Wataru; Okinaga, Toshinori; Kaneuji, Takeshi; Mitsugi, Sho; Sakurai, Takuma; Habu, Manabu; Yoshioka, Izumi; Tominaga, Kazuhiro; and others

    2015-05-01

    Interleukin (IL)-33 is a recently discovered proinflammatory cytokine that belongs to the IL-1 family. Several studies have reported that IL-33 inhibits osteoclast differentiation. However, the mechanism of IL-33 regulation of osteoclastogenesis remains unclear. In the present study, we examined the effect of IL-33 on osteoclast formation in vitro. IL-33 suppressed osteoclast formation in both mouse bone marrow cells and monocyte/macrophage cell line RAW264.7 cells induced by receptor activator of NF-κB ligand (RANKL) and/or macrophage stimulating factor (M-CSF). IL-33 also inhibited the expression of RANKL-induced nuclear factor of activated T-cell cytoplasmic 1 (NFATc1), thereby decreasing the expression of osteoclastogenesis-related marker genes, including Cathepsin K, Osteoclast stimulatory transmembrane protein (Oc-stamp) and Tartrate-resistant acid phosphatase (Trap). Blockage of IL-33-ST2 binding suppressed the IL-33-mediated inhibition of NFATc1. RANKL-induced B-lymphocyte-induced maturation protein-1 (Blimp-1) expression was also suppressed by IL-33, which was followed by the stimulation of anti-osteoclastic genes such as interferon regulatory factor-8 (IRF-8). These results suggest that IL-33-ST2 interactions down-regulate both RANKL-induced NFATc1 activation and osteoclast differentiation via the regulation of Blimp-1 and IRF-8 expression. - Highlights: • IL-33 inhibits RANKL-induced osteoclast formation. • IL-33 has inhibitory effect on the RANKL-induced NFATc1 expression. • IL-33-induced NFATc1 suppression depends on the regulation of Blimp-1 and IRF-8.

  16. Secretary Chu Announces Agreement on FutureGen Project in Mattoon, IL |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Agreement on FutureGen Project in Mattoon, IL Secretary Chu Announces Agreement on FutureGen Project in Mattoon, IL June 12, 2009 - 12:00am Addthis Washington, D.C. - U.S. Secretary of Energy Steven Chu today announced an agreement with the FutureGen Alliance that advances the construction of the first commercial scale, fully integrated, carbon capture and sequestration project in the country in Mattoon, Illinois. "This important step forward for FutureGen reflects

  17. IL.26

    Office of Legacy Management (LM)

    ... by the AEC Health and Safety Laboratory; (4) establishment of a program for area clearance after each cycle; (5) supply of the uranium billets allocated for a work cycle ...

  18. DOE Zero Energy Ready Home Case Study: StreetScape Development, LLC, Libertyville, IL, Custom

    Broader source: Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready Home in Libertyville, IL, that scored HERS 45 without PV. This 2,763-square-foot custom home has advanced framed walls with R-20 of open-cell spray foam, R-49 open-cell spray-foam sealed attic, an HRV, and a tankless water heater for hydro coil furnace with high-velocity, small-diameter ducts.

  19. Demonstration Assessment of Light-Emitting Diode (LED) Accent Lighting at the Field Museum in Chicago, IL

    SciTech Connect (OSTI)

    Myer, Michael; Kinzey, Bruce R.

    2010-12-10

    This report reviews a demonstration of light-emitting diode (LED) accent lighting compared to halogen (typical) accent lighting in a gallery of the Field Museum in Chicago, IL.

  20. Delivery of human NKG2D-IL-15 fusion gene by chitosan nanoparticles to enhance antitumor immunity

    SciTech Connect (OSTI)

    Yan, Chen; Jie, Leng; Yongqi, Wang; Weiming, Xiao; Juqun, Xi; Yanbing, Ding; Li, Qian; Xingyuan, Pan; Mingchun, Ji; Weijuan, Gong

    2015-07-31

    Nanoparticles are becoming promising carriers for gene delivery because of their high capacity in gene loading and low cell cytotoxicity. In this study, a chitosan-based nanoparticle encapsulated within a recombinant pcDNA3.1-dsNKG2D-IL-15 plasmid was generated. The fused dsNKG2D-IL-15 gene fragment consisted of double extracellular domains of NKG2D with IL-15 gene at downstream. The average diameter of the gene nanoparticles ranged from 200 nm to 400 nm, with mean zeta potential value of 53.8 ± 6.56 mV. The nanoparticles which were loaded with the dsNKG2D-IL-15 gene were uptaken by tumor cells with low cytotoxicity. Tumor cells pre-transfected by gene nanopartilces stimulated NK and T cells in vitro. Intramuscular injection of gene nanoparticles suppressed tumor growth and prolonged survival of tumor-bearing mice through activation of NK and CD8{sup +} T cells. Thus, chitosan-based nanoparticle delivery of dsNKG2D-IL-15 gene vaccine can be potentially used for tumor therapy. - Highlights: • Generation of a nanoparticle for delivery of dsNKG2D-IL-15 gene. • Characterization of the gene nanoparticle. • Antitumor activity mediated by the gene nanoparticle.

  1. DFPARThIl!NT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEPA DETERlIfiNATION

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    s DFPARThIl!NT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEPA DETERlIfiNATION Page 1 of3 RECIPIENT :State of Hawaii DBEOT STATE : HI PROJECf TITLE: Loan Loss Reserve Funding Opportunity Announc~ment Number DE-FOA-0000052 Procurement Inslrument Number DE-EEOOOO216 NEPA Control Number em Number GF0-0000216-001 GO Based on my review ofthe informalion concerning the proposed aClion, as NEPA Compliance Officer (authorized under DOE Order 451.1A), I have made the following determination: ex, EA, EIS

  2. Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors

    SciTech Connect (OSTI)

    Jin, Sun Hee; Choi, Dalwoong; Chun, Young-Jin; Noh, Minsoo

    2014-10-15

    Keratinocytes are the major cellular components of human epidermis and play a key role in the modulating cutaneous inflammation and toxic responses. In human chronic skin diseases, the common skin inflammatory phenotypes like skin barrier disruption and epidermal hyperplasia are manifested in epidermal keratinocytes by interactions with T helper (Th) cells. To find a common gene expression signature of human keratinocytes in chronic skin diseases, we performed a whole genome microarray analysis on normal human epidermal keratinocytes (NHKs) treated with IFNγ, IL-4, IL-17A or IL-22, major cytokines from Th1, Th2, Th17 or Th22 cells, respectively. The microarray results showed that the four genes, IL-24, PDZK1IP1, H19 and filaggrin, had common expression profiles in NHKs exposed to Th cell cytokines. In addition, the acute phase pro-inflammatory cytokines, IL-1β, IL-6 and TNFα, also change the gene transcriptional profile of IL-24, PDZK1IP1, H19, and filaggrin in NHKs as those of Th cytokines. Therefore, the signature gene set, consisting of IL-24, PDZK1IP1, H19, and filaggrin, provides essential insights for understanding the process of cutaneous inflammation and toxic responses. We demonstrate that environmental toxic stressors, such as chemical irritants and ultraviolet irradiation stimulate the production of IL-24 in NHKs. IL-24 stimulates the JAK1-STAT3 and MAPK pathways in NHKs, and promotes the secretion of pro-inflammatory mediators IL-8, PGE2, and MMP-1. These results suggest that keratinocyte-derived IL-24 participates in the positive feedback regulation of epidermal inflammation in response to both endogenous and environmental toxic stressors. - Highlights: • Cutaneous inflammatory gene signature consists of PDZK1IP1, IL-24, H19 and filaggrin. • Pro-inflammatory cytokines increase IL-24 production in human keratinocytes. • Environmental toxic stressors increase IL-24 production in human keratinocytes. • IL-24 stimulates human keratinocytes to

  3. IL1{beta}-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells

    SciTech Connect (OSTI)

    Zhu, Yingting; Tissue Tech Inc, Miami, FL 33173 ; Zhu, Min; Lance, Peter

    2012-11-15

    COX-2 is a major inflammatory mediator implicated in colorectal inflammation and cancer. However, the exact origin and role of COX-2 on colorectal inflammation and carcinogenesis are still not well defined. Recently, we reported that COX-2 and iNOS signalings interact in colonic CCD18Co fibroblasts. In this article, we investigated whether activation of COX-2 signaling by IL1{beta} in primary colonic fibroblasts obtained from normal and cancer patients play a critical role in regulation of proliferation and invasiveness of human colonic epithelial cancer cells. Our results demonstrated that COX-2 level was significantly higher in cancer associated fibroblasts than that in normal fibroblasts with or without stimulation of IL-1{beta}, a powerful stimulator of COX-2. Using in vitro assays for estimating proliferative and invasive potential, we discovered that the proliferation and invasiveness of the epithelial cancer cells were much greater when the cells were co-cultured with cancer associated fibroblasts than with normal fibroblasts, with or without stimulation of IL1{beta}. Further analysis indicated that the major COX-2 product, prostaglandin E{sub 2}, directly enhanced proliferation and invasiveness of the epithelial cancer cells in the absence of fibroblasts. Moreover, a selective COX-2 inhibitor, NS-398, blocked the proliferative and invasive effect of both normal and cancer associate fibroblasts on the epithelial cancer cells, with or without stimulation of IL-1{beta}. Those results indicate that activation of COX-2 signaling in the fibroblasts plays a major role in promoting proliferation and invasiveness of the epithelial cancer cells. In this process, PKC is involved in the activation of COX-2 signaling induced by IL-1{beta} in the fibroblasts.

  4. Expression of low-, intermediate-, and high-affinity IL-2 receptors on B cell lines derived from patients with undifferentiated lymphoma of Burkitt's and non-Burkitt's types

    SciTech Connect (OSTI)

    Benjamin, D.; Rosolen, A.; Wormsley, S.B.; DeBault, L.E.; Colamonici, O.R. )

    1990-08-01

    IL-2 receptors on T cells exist in at least three forms which differ in their ligand-binding affinity. The low-affinity IL-2 receptor (IL-2R) consists of the 55-kDa Tac protein (p55 alpha), the intermediate-affinity site corresponds to the 70-kDa molecule (p70 beta), and the high-affinity IL-2R consists of a noncovalent heterodimeric structure involving both p55 alpha and p70 beta. We studied 24 B cell lines (8 EBV-negative and 16 EBV-positive) for IL-2R expression in the presence or absence of the tumor promoter, teleocidin. 125I-IL-2 radioreceptor binding assays and crosslinking studies demonstrated the sole expression of p55 alpha in EBV-negative cell lines only, whereas p55 alpha present in EBV-positive cell lines was always associated with p70 beta to construct high-affinity IL-2R. p70 beta was not detected in any of the EBV-negative cell lines, but was expressed on most of the EBV-positive cell lines (13 of 16). Our data also indicate that the expression of p55 alpha and p70 beta by radiolabeling correlates with their expression in flow cytometry, and that a large excess of p55 alpha is required to construct high-affinity IL-2R. Coexpression of p55 alpha and p70 beta on human B cells contributed to constructing high-affinity IL-2R hybrid complex as shown by rapid association rate contributed by p55 alpha and slow dissociation rate by p70 beta; teleocidin's ability to induce p55 alpha on cell lines which express p70 beta only, resulting in appearance of high-affinity IL-2R; and blocking p55 alpha by anti-Tac mAb in cell lines which constitutively express high-affinity IL-2R eliminated both high- and low-affinity components. The existence of low, intermediate, and high IL-2R on human B cells bears important future implications for understanding the mechanism of IL-2 signaling and the role of IL-2 in B cell activation, proliferation, and differentiation.

  5. Eu3+ as a dual probe for the determination of IL anion donor power: A combined luminescence spectroscopic and electrochemical approach

    SciTech Connect (OSTI)

    Babai, Arash; Kopiec, Gabriel; Lackmann, Anastasia; Mallick, Bert; Pitula, Slawomir; Tang, Sifu; Mudring, Anja-Verena

    2014-04-01

    This work is aimed at giving proof that Eu(Tf2N)(3) (Tf2N = bis(trifluoromethanesulfonyl)amide) can act as both an optical and electrochemical probe for the determination of the Lewis acidity of an ionic liquid anion. For that reason the luminescence spectra and cyclic voltammograms of dilute solutions of Eu(Tf2N)(3) in various ionic liquids were investigated. The Eu2+/3+ redox potential in the investigated ILs can be related to the Lewis basicity of the IL anion. The IL cation had little influence. The lower the determined halfwave potential, the higher the IL anion basicity. The obtained ranking can be confirmed by luminescence spectroscopy where a bathochromic shift of the D-5(0) -> F-7(4) transition indicates a stronger Lewis basicity of the IL anion. (C) 2014 Published by Elsevier B.V.

  6. C E N T R A L F IL E S

    Office of Legacy Management (LM)

    ;zJy, y J l . T;? : Tflj~j : - ..- ":'cyi$:T,;L . . :z*:, 0 , _ _ : 7 r;-2 :: '7 .' . A 1 :- :-; '3 s:s:a *;iy,:;.~ ~ r.3 , :,& . fJ . A . -y& ~ :.-, ;,!*3 , J. -. v :+ tn g C E N T R A L F IL E S ~ > m cTpnz '3 F T E iP T h e o b ;ectl'.'e o f th e ? = r i ~ ';lila to d 9 c u s s th e h e a l th a n d s a fe ty a s p e c ts o f a - p r O p O S e d O f? -31'te te s t involving electro n b e a m m e l tin g o f s o l & 2 a m n l u m n e tal a t th e S ta u ffer-Temescal C o m

  7. Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 signaling

    SciTech Connect (OSTI)

    Zhang, Bing; Liu, Caini; Qian, Wen; Han, Yue; Li, Xiaoxia; Deng, Junpeng

    2014-05-01

    Crystal structure of the SEFIR domain from human IL-17 receptor A provides new insights into IL-17 signaling. Interleukin 17 (IL-17) cytokines play a crucial role in mediating inflammatory and autoimmune diseases. A unique intracellular signaling domain termed SEFIR is found within all IL-17 receptors (IL-17Rs) as well as the key adaptor protein Act1. SEFIR-mediated protein–protein interaction is a crucial step in IL-17 cytokine signaling. Here, the 2.3 Å resolution crystal structure of the SEFIR domain of IL-17RA, the most commonly shared receptor for IL-17 cytokine signaling, is reported. The structure includes the complete SEFIR domain and an additional α-helical C-terminal extension, which pack tightly together to form a compact unit. Structural comparison between the SEFIR domains of IL-17RA and IL-17RB reveals substantial differences in protein topology and folding. The uniquely long insertion between strand βC and helix αC in IL-17RA SEFIR is mostly well ordered, displaying a helix (αCC′{sub ins}) and a flexible loop (CC′). The DD′ loop in the IL-17RA SEFIR structure is much shorter; it rotates nearly 90° with respect to the counterpart in the IL-17RB SEFIR structure and shifts about 12 Å to accommodate the αCC′{sub ins} helix without forming any knots. Helix αC was identified as critical for its interaction with Act1 and IL-17-stimulated gene expression. The data suggest that the heterotypic SEFIR–SEFIR association via helix αC is a conserved and signature mechanism specific for IL-17 signaling. The structure also suggests that the downstream motif of IL-17RA SEFIR together with helix αC could provide a composite ligand-binding surface for recruiting Act1 during IL-17 signaling.

  8. Single high-dose irradiation aggravates eosinophil-mediated fibrosis through IL-33 secreted from impaired vessels in the skin compared to fractionated irradiation

    SciTech Connect (OSTI)

    Lee, Eun-Jung; Kim, Jun Won; Yoo, Hyun; Kwak, Woori; Choi, Won Hoon; Cho, Seoae; Choi, Yu Jeong; Lee, Yoon-Jin; Cho, Jaeho

    2015-08-14

    We have revealed in a porcine skin injury model that eosinophil recruitment was dose-dependently enhanced by a single high-dose irradiation. In this study, we investigated the underlying mechanism of eosinophil-associated skin fibrosis and the effect of high-dose-per-fraction radiation. The dorsal skin of a mini-pig was divided into two sections containing 4-cm{sup 2} fields that were irradiated with 30 Gy in a single fraction or 5 fractions and biopsied regularly over 14 weeks. Eosinophil-related Th2 cytokines such as interleukin (IL)-4, IL-5, and C–C motif chemokine-11 (CCL11/eotaxin) were evaluated by quantitative real-time PCR. RNA-sequencing using 30 Gy-irradiated mouse skin and functional assays in a co-culture system of THP-1 and irradiated-human umbilical vein endothelial cells (HUVECs) were performed to investigate the mechanism of eosinophil-mediated radiation fibrosis. Single high-dose-per-fraction irradiation caused pronounced eosinophil accumulation, increased profibrotic factors collagen and transforming growth factor-β, enhanced production of eosinophil-related cytokines including IL-4, IL-5, CCL11, IL-13, and IL-33, and reduced vessels compared with 5-fraction irradiation. IL-33 notably increased in pig and mouse skin vessels after single high-dose irradiation of 30 Gy, as well as in irradiated HUVECs following 12 Gy. Blocking IL-33 suppressed the migration ability of THP-1 cells and cytokine secretion in a co-culture system of THP-1 cells and irradiated HUVECs. Hence, high-dose-per-fraction irradiation appears to enhance eosinophil-mediated fibrotic responses, and IL-33 may be a key molecule operating in eosinophil-mediated fibrosis in high-dose-per fraction irradiated skin. - Highlights: • Single high-dose irradiation aggravates eosinophil-mediated fibrosis through IL-33. • Vascular endothelial cells damaged by high-dose radiation secrete IL-33. • Blocking IL-33 suppressed migration of inflammatory cells and cytokine secretion. • IL

  9. HIA 2015 DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Evolutionary Home Builders The Adaptation Home Geneva, IL DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies

  10. DOE Zero Energy Ready Home Case Study 2013: Weiss Building & Development, LLC., Custom Home, Downer Grove, IL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    LLC Custom Home Downers Grove, IL BUILDING TECHNOLOGIES OFFICE The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR for Homes Version 3 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in to give you

  11. DOE Zero Energy Ready Home Case Study: 2013 Weiss Building & Development, LLC., System Home, River Forest, IL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    LLC System Home River Forest, IL BUILDING TECHNOLOGIES OFFICE The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR for Homes Version 3 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in to give you superior

  12. Facile fabrication of rutile monolayer films consisting of well crystalline nanorods by following an IL-assisted hydrothermal route

    SciTech Connect (OSTI)

    Peng Peng; Liu Xiaodi; Sun, Chuansheng; Ma Jianmin; Zheng Wenjun

    2009-05-15

    In this study, rutile films consisting of rectangular nanorods were facilely deposited on glass substrates from strongly acid solution of TiCl{sub 4}. The highly ordered array of nanorods was realized in presence of ionic liquid (IL) of [Bmim]Br by following a hydrothermal process. In this process, Degussa P25 nanoparticles served as seeds that were pre-deposited on the substrates to facilitate the array of rutile nanorods. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Raman spectrum were used to characterize the obtained nanorod films. The measurements showed that the nanorods were rectangular with width of 100-200 nm and length of more than 1 {mu}m, and grew up typically along c-axis to form the arrays against the substrate. The presence of IL was found vital for the formation of rutile nanorods, and the suitable molar ratio of [Bmim]Br to TiCl{sub 4} ranged from 500:1 to 1500:1. The excessive [Bmim]Br may hinder the precipitation of rutile particles. - Graphical abstract: The rutile film consisting of rectangular nanorods is successfully deposited on glass substrate in presence of ionic liquid (IL) of [Bmim]Br. The nanorods were rectangular with width of 100-200 nm and length of more than 1 {mu}m, which grew up typically along c-axis to form the arrays against the substrate.

  13. IL-2R{gamma} gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease

    SciTech Connect (OSTI)

    Henthorn, P.S.; Fimiani, V.M.; Patterson, D.F.

    1994-09-01

    X-linked severe combined immunodeficiency (SCID) is characterized by profound defects in cellular and humoral immunity and, in humans, is associated with mutations in the gene for the {gamma} chain of the IL-2 receptor (IL-2R{gamma}). We have examined this gene in a colony of dogs established from a single X-linked SCID carrier female. Affected dogs have a 4-bp deletion in the first exon of the IL-2R{gamma} gene, which precludes the production of a functional protein, demonstrating that the canine disease is a true homologue of human X-linked SCID. 37 refs., 3 figs.

  14. HIA 2015 DOE Zero Energy Ready Home Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    BrightLeaf Homes McCormick Avenue Brookfield, IL DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are

  15. Activation of IL-2 receptor {alpha}-chain gene by individual members of the rel oncogene family in association with serum response factor

    SciTech Connect (OSTI)

    Pierce, J.W.; Jamieson, C.A.; Ross, J.L.

    1995-08-15

    Expression of the IL-2R{alpha} gene is regulated by members of the c-Rel/NF-{kappa}B family of transcription factors binding to the {kappa}B site in the promoter. Previous work has not defined the role of individual members of the c-Rel family in the activation of the IL-2R{alpha} gene. Using the COS cell system, we were able to reconstitute the regulation of the IL-2R{alpha} promoter by expressing cloned Rel family members with serum response factor (SRF). We found that c-rel alone activated the IL-2R{alpha} promoter only weakly but worked with the p50 subunit of NF-{kappa}B (NFKB1) to give a higher level of expression. We showed that c-rel heterodimerizes with p50 and the amount of this heterodimer correlated with the level of IL-2R{alpha} gene expression. Our results provide evidence that c-rel/p50 heterodimers activate gene expression in the context of a cellular promoter. We show that c-rel or p65 can cooperate with SRF in the activation of this promoter and the transactivation by c-rel with SRF was enhanced by p50. Synergistic activation required both {kappa}B an CArG sites, and binding studies show that these that these adjacent sites can be occupied simultaneously. The transactivation observed with cloned transcription factors mimics the physiologic induction of the IL-2R{alpha} gene since multiple sequence elements cooperate to give gene activation. The data support the model that c-rel/p50 or p65 can cooperate with SRF to specifically target the expression of the IL-2R{alpha} gene in activated T cells.

  16. Immunosuppressive effect of the anti-IL-2-receptor monoclonal antibody, AMT-13, on organ-cultured fetal pancreas allograft survival

    SciTech Connect (OSTI)

    Burkhardt, K.; Loughnan, M.S.; Diamantstein, T.; Mandel, T.E.

    1988-11-01

    Recently, prolongation of cardiac allograft survival in mice was reported using a rat anti-IL-2R mAb (AMT-13). However, its immunosuppressive action in vivo, alone and in combination with other immunosuppressants, and its effect on other organ transplants has not been extensively studied. We grafted cultured fetal pancreas from CBA (H-2k) donors to Balb/c (H-2d) mice. Recipients were treated with 10 consecutive daily injections each of 20 micrograms AMT-13 only, or with an additional mild immunosuppression of 350 rads irradiation. Control groups received rat immunoglobulin or 350 rads irradiation. Graft survival and the phenotype of infiltrating cells were assessed histologically and immunocytochemically on days 12, 17, and 21, and soluble IL-2R levels were measured in the serum with a quantitative ELISA in all recipients. Two of five grafts in the AMT-13-treated group had islets on day 12 posttransplantation despite lymphocytic infiltration in all grafts, while at this time all grafts of rat Ig treated control mice were completely rejected with only scar tissue and a few lymphocytes remaining. Additional immunosuppression with 350 rads irradiation had a marked additive effect with AMT-13. Soluble IL-2R levels in the serum of untreated recipients were not elevated compared with normal serum levels, but recipients injected with AMT-13 had multifold increased soluble IL-2R levels. The percentage of IL-2R+ cells in the grafts of AMT-13-treated animals was either normal (less than 5%) or increased (20%) in the additionally irradiated mice, providing strong evidence that the immunosuppressive effect of AMT-13 is not due to a depletion of activated IL-2R+ lymphocytes.

  17. Thermal spray removal of lead-based paint from the viaduct bridge at Rock Island Arsenal, IL. Final report

    SciTech Connect (OSTI)

    Boy, J.H.; Weber, R.A.; Kumar, A.

    1998-06-01

    This report documents a field demonstration at the Rock Island Arsenal, IL, that validated the thermal spray vitrification (TSV) process as a safe and effective technique for removing lead-based paint from a steel bridge. Specially formulated glass was applied in a molten state to painted steel using a conventional thermal spray application system. The molten glass reacts with the paint, and encapsulates the lead. The cooled glass readily cracks and falls off, removing the paint. After onsite remelting of the glass waste to complete the encapsulation process, the final waste product is chemically inert and may be disposed of in a regular landfill. The Illinois Environmental Protection Agency, Division of Air Pollution Control determined that the glass remelt process could be considered a paint-removal operation for which no air quality permit was required.

  18. ROS and NF-{kappa}B are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes

    SciTech Connect (OSTI)

    Ye Shefang Wu Yihui; Hou Zhenqing; Zhang Qiqing

    2009-02-06

    Carbon nanotubes (CNTs) have potential applications in biosensors, tissue engineering, and biomedical devices because of their unique physico-chemical, electronic and mechanical properties. However, there is limited literature data available concerning the biological properties and toxicity of CNTs. This study aimed to assess the toxicity exhibited by multi-walled CNTs (MWCNTs) and to elucidate possible molecular mechanisms underlying the biological effects of MWCNTs in A549 cells. Exposing A549 cells to MWCNTs led to cell death, changes in cell size and complexity, reactive oxygen species (ROS) production, interleukin-8 (IL-8) gene expression and nuclear factor (NF)-{kappa}B activation. Treatment of A549 cells with antioxidants prior to adding MWCNTs decreased ROS production and abrogated expression of IL-8 mRNA. Pretreatment of A549 cells with NF-{kappa}B inhibitors suppressed MWCNTs-induced IL-8 mRNA expression. These results indicate that MWCNTs are able to induce expression of IL-8 in A549 cells, at least in part, mediated by oxidative stress and NF-{kappa}B activation.

  19. XL-A A.&lx A!i' X!Ii?Z IL';;i'

    Office of Legacy Management (LM)

    -- :I 9 .a # ** ,. . . m . . pJ;-,L' ,' i:-t.T .)r' yjs JzZ~ J~~;L,;.~;r 1:). 2 . m I;S~X:T ?I?. ::.:-25-::%-I.:.Glu~ XL-A A.&lx A!i' X!Ii?Z IL';;i' , X2,-d c i.XZEA?, th At3Ac Z:r.zr.~ f4z22s343n >q3 pquask$ tL,..- psg zd of &,-cc b&ldjmms: >UAeT; :,:,. &&;j L' *r: ! 3 ..m 3CCU"pxy &jJdbc ' Au ..3* 6u, I;..:; ' 2. CL&51, 1;; *-- l - l &j-2+; z5 a?, ft . IALP !13. f&%-i;& 2$&J 3;. ft.1 sq, ft.; &ii+ m* i.3. $+, hZE2X, it >a tmn

  20. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

    SciTech Connect (OSTI)

    Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan

    2013-11-15

    Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: Arsenite evokes IL-6 secretion. IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. Inflammation is involved in arsenite-induced EMT.

  1. IL Wted States Government

    Office of Legacy Management (LM)

    the building slab and small amounts of residual uranium in soil outside the building. ... EM-42 3. Wagoner, EM-421 W. A. Williams, EM-421 L. Price, OR -.- .-.. . .i y:-.

  2. Celecoxib offsets the negative renal influences of cyclosporine via modulation of the TGF-?1/IL-2/COX-2/endothelin ET{sub B} receptor cascade

    SciTech Connect (OSTI)

    El-Gowelli, Hanan M.; Helmy, Maged W.; Ali, Rabab M.; El-Mas, Mahmoud M.

    2014-03-01

    Endothelin (ET) signaling provokes nephrotoxicity induced by the immunosuppressant drug cyclosporine A (CSA). We tested the hypotheses that (i): celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, counterbalances renal derangements caused by CSA in rats and (ii) the COX-2/endothelin ET{sub B} receptor signaling mediates the CSA-celecoxib interaction. Ten-day treatment with CSA (20 mg/kg/day) significantly increased biochemical indices of renal function (serum urea, creatinine), inflammation (interleukin-2, IL-2) and fibrosis (transforming growth factor-?{sub 1}, TGF-?{sub 1}). Histologically, CSA caused renal tubular atrophy along with interstitial fibrosis. These detrimental renal effects of CSA were largely reduced in rats treated concurrently with celecoxib (10 mg/kg/day). We also report that cortical glomerular and medullary tubular protein expressions of COX-2 and ET{sub B} receptors were reduced by CSA and restored to near-control values in rats treated simultaneously with celecoxib. The importance of ET{sub B} receptors in renal control and in the CSA-celecoxib interaction was further verified by the findings (i) most of the adverse biochemical, inflammatory, and histopathological profiles of CSA were replicated in rats treated with the endothelin ET{sub B} receptor antagonist BQ788 (0.1 mg/kg/day, 10 days), and (ii) the BQ788 effects, like those of CSA, were alleviated in rats treated concurrently with celecoxib. Together, the data suggest that the facilitation of the interplay between the TGF-?1/IL-2/COX-2 pathway and the endothelin ET{sub B} receptors constitutes the cellular mechanism by which celecoxib ameliorates the nephrotoxic manifestations of CSA in rats. - Highlights: Celecoxib abolishes nephrotoxic manifestations of CSA in rats. Blockade of ETB receptors by BQ788 mimicked the nephrotoxic effects of CSA. CSA or BQ788 reduces renal protein expression of COX-2 and endothelin ETB receptors. Enhanced TGF?1/IL-2/COX2/ETB signaling

  3. Category:Wichita, KS | Open Energy Information

    Open Energy Info (EERE)

    Wichita KS ... 64 KB SVLargeHotel Wichita KS Westar Energy Inc.png SVLargeHotel Wichita K... 59 KB SVLargeOffice Wichita KS Westar Energy Inc.png SVLargeOffice Wichita ... 64 KB...

  4. TGF-{beta}1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-{kappa}B/IL-6/MMP-2

    SciTech Connect (OSTI)

    Binker, Marcelo G.; CBRHC Research Center, Buenos Aires ; Binker-Cosen, Andres A.; Gaisano, Herbert Y.; Cosen, Rodica H. de; Cosen-Binker, Laura I.

    2011-02-04

    Research highlights: {yields} Rac1 mediates TGF-{beta}1-induced SW1990 invasion through MMP-2 secretion and activation. {yields} NADPH-generated ROS act downstream of Rac1 in TGF-{beta}1-challenged SW1990 cells. {yields} TGF-{beta}1-stimulated ROS activate NF-{kappa}B in SW1990 cells. {yields} NF{kappa}B-induced IL-6 release is required for secretion and activation of MMP-2 in SW1990 cells. -- Abstract: Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-{beta}1) has been shown to increase both secretion of MMP-2 and invasion by several pancreatic cancer cell types. In the present study, we investigated the signaling pathway involved in TGF-{beta}1-promoted MMP-2 secretion and invasion by human pancreatic cancer cells SW1990. Using specific inhibitors, we found that stimulation of these tumor cells with TGF-{beta}1 induced secretion and activation of the collagenase MMP-2, which was required for TGF-{beta}1-stimulated invasion. Our results also indicate that signaling events involved in TGF-{beta}1-enhanced SW1990 invasiveness comprehend activation of Rac1 followed by generation of reactive oxygen species through nicotinamide adenine dinucleotide phosphate-oxidase, activation of nuclear factor-kappa beta, release of interleukin-6, and secretion and activation of MMP-2.

  5. Category:Goodland, KS | Open Energy Information

    Open Energy Info (EERE)

    KS Jump to: navigation, search Go Back to PV Economics By Location Media in category "Goodland, KS" The following 16 files are in this category, out of 16 total....

  6. US ENC IL Site Consumption

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    electricity consumption in the state low relative to other parts of the U.S. * Over 80% of Illinois households use natural gas as their main space heating fuel. CONSUMPTION BY END ...

  7. US ENC IL Site Consumption

    U.S. Energy Information Administration (EIA) Indexed Site

    Illinois, Indiana, Michigan, Ohio, Wisconsin All data from EIA's 2009 Residential Energy Consumption Survey www.eia.govconsumptionresidential Space heating Water ...

  8. Zinc ferrite nanoparticles activate IL-1b, NFKB1, CCL21 and NOS2 signaling to induce mitochondrial dependent intrinsic apoptotic pathway in WISH cells

    SciTech Connect (OSTI)

    Saquib, Quaiser; Al-Khedhairy, Abdulaziz A.; Ahmad, Javed; Siddiqui, Maqsood A.; Dwivedi, Sourabh; Khan, Shams T.; Musarrat, Javed

    2013-12-01

    The present study has demonstrated the translocation of zinc ferrite nanoparticles (ZnFe{sub 2}O{sub 4}-NPs) into the cytoplasm of human amnion epithelial (WISH) cells, and the ensuing cytotoxicity and genetic damage. The results suggested that in situ NPs induced oxidative stress, alterations in cellular membrane and DNA strand breaks. The [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) and neutral red uptake (NRU) cytotoxicity assays indicated 64.48 1.6% and 50.73 2.1% reduction in cell viability with 100 ?g/ml of ZnFe{sub 2}O{sub 4}-NPs exposure. The treated WISH cells exhibited 1.2-fold higher ROS level with 0.9-fold decline in membrane potential (??m) and 7.4-fold higher DNA damage after 48 h of ZnFe{sub 2}O{sub 4}-NPs treatment. Real-time PCR (qPCR) analysis of p53, CASP 3 (caspase-3), and bax genes revealed 5.3, 1.6, and 14.9-fold upregulation, and 0.18-fold down regulation of bcl 2 gene vis--vis untreated control. RT{sup 2} Profiler PCR array data elucidated differential up-regulation of mRNA transcripts of IL-1b, NFKB1, NOS2 and CCL21 genes in the range of 1.5 to 3.7-folds. The flow cytometry based cell cycle analysis suggested the transfer of 15.2 2.1% (p < 0.01) population of ZnFe{sub 2}O{sub 4}-NPs (100 ?g/ml) treated cells into apoptotic phase through intrinsic pathway. Over all, the data revealed the potential of ZnFe{sub 2}O{sub 4}-NPs to induce cellular and genetic toxicity in cells of placental origin. Thus, the significant ROS production, reduction in ??m, DNA damage, and activation of genes linked to inflammation, oxidative stress, proliferation, DNA damage and repair could serve as the predictive toxicity and stress markers for ecotoxicological assessment of ZnFe{sub 2}O{sub 4}-NPs induced cellular and genetic damage. - Highlights: First report on the molecular toxicity of ZnFe{sub 2}O{sub 4}-NPs in cells of placental origin WISH cells treated with ZnFe{sub 2}O{sub 4}-NPs exhibited cytoplasmic localization of NPs

  9. Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism

    SciTech Connect (OSTI)

    Murugaiyan, Jayaseelan; Rockstroh, Maxie; Wagner, Juliane; Baumann, Sven; Schorsch, Katrin; Trump, Saskia; Lehmann, Irina; Bergen, Martin von; Tomm, Janina M.

    2013-06-15

    There is a clear evidence that environmental pollutants, such as benzo[a]pyrene (B[a]P), can have detrimental effects on the immune system, whereas the underlying mechanisms still remain elusive. Jurkat T cells share many properties with native T lymphocytes and therefore are an appropriate model to analyze the effects of environmental pollutants on T cells and their activation. Since environmental compounds frequently occur at low, not acute toxic concentrations, we analyzed the effects of two subtoxic concentrations, 50 nM and 5 μM, on non- and activated cells. B[a]P interferes directly with the stimulation process as proven by an altered IL-2 secretion. Furthermore, B[a]P exposure results in significant proteomic changes as shown by DIGE analysis. Pathway analysis revealed an involvement of the AhR independent Nrf2 pathway in the altered processes observed in unstimulated and stimulated cells. A participation of the Nrf2 pathway in the change of IL-2 secretion was confirmed by exposing cells to the Nrf2 activator tBHQ. tBHQ and 5 μM B[a]P caused similar alterations of IL-2 secretion and glutamine/glutamate metabolism. Moreover, the proteome changes in unstimulated cells point towards a modified regulation of the cytoskeleton and cellular stress response, which was proven by western blotting. Additionally, there is a strong evidence for alterations in metabolic pathways caused by B[a]P exposure in stimulated cells. Especially the glutamine/glutamate metabolism was indicated by proteome pathway analysis and validated by metabolite measurements. The detrimental effects were slightly enhanced in stimulated cells, suggesting that stimulated cells are more vulnerable to the environmental pollutant model compound B[a]P. - Highlights: • B[a]P affects the proteome of Jurkat T cells also at low concentrations. • Exposure to B[a]P (50 nM, 5 μM) did not change Jurkat T cell viability. • Both B[a]P concentrations altered the IL-2 secretion of stimulated cells.

  10. actos_il_v05.ai

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Administration and project management Acquisition and Project Management Office volunteers get up-close look at Office of Secure Transportation exercise Contracting professionals from the NNSA Acquisition & Project Management (APM) Field Program Section (FPS) recently served as role players for Office of Secure Transportation (OST) training exercises in Arkansas and Oklahoma. OST Federal Agents transport U.S. nuclear weapons, components and... SNL Starting Points Sandia Field Office Home

  11. Fermilab Cultural Events in Batavia, IL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Eugene Cheng, Scientist in Residence, School of the Art Institute, Chicago and Professor, University of Sheffield, UK - July 15, 2016 @ 8 pm - 7 Lecture by Vanessa Hill of Brain ...

  12. IL.06-123 057 I I

    Office of Legacy Management (LM)

    ... Perch10ric and picric acid salts are explosive; they can be detonated by shock, impact, heat, or friction. Before work was performed on the ducts, field tests were performed to ...

  13. DOE - Office of Legacy Management -- Spencer Chemical Co - KS 0-01

    Office of Legacy Management (LM)

    KS 0-01 FUSRAP Considered Sites Site: SPENCER CHEMICAL CO. (KS.0-01 ) Eliminated from further consideration under FUSRAP - an AEC licensed operation Designated Name: Not Designated Alternate Name: Jayhawk Works KS.0-01-1 Location: Pittsburg , Kansas KS.0-01-1 Evaluation Year: 1985 KS.0-01-2 Site Operations: Processed enriched uranium (UF-6) and scrap to produce primarily uranium dioxide (UO-2) under AEC licenses. KS.0-01-3 KS.0-01-4 Site Disposition: Eliminated - No Authority - AEC licensed

  14. Control of Well KS-8 in the Kilauea Lower East Rift Zone | Open...

    Open Energy Info (EERE)

    Control of Well KS-8 in the Kilauea Lower East Rift Zone Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference Paper: Control of Well KS-8 in the Kilauea...

  15. Quadrennial Energy Review August 8, 2014 Chicago , Il.

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ernie Perry, PhD. ebperry@wisc.edu University Of Wisconsin - Madison 2 Freight corridors are multi-state, multi- modal economic networks. Contents o MAFC states are freight states ...

  16. R. Tayloe, NuFact'09 Chicago, IL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - W n p CCQE 3 CCQE models The canonical model for the CCQE process is straightforward, and well-constrained. It looks something like this: - Llewellyn-Smith formalism...

  17. Increasing Sugar Yields with IL-final-sm

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a feedstock agnostic ionic liquid pretreatment process that: Agriculture Waste Woody Biomass Mixed Feedstocks Municipal Solid Waste (MSW) Biofuels Program Contact: Blake...

  18. OIL WELL REMEDIATION IN CLAY AND WAYNE COUNTIES, IL

    SciTech Connect (OSTI)

    Peter L. Dakuras; Larry Stieber; Dick Young

    2003-02-01

    This is the first technical progress report of the remediation of two wells and a water injection well in Clay County, Illinois. The location is identified as the Routt lease and the wells will be identified as the Routt No.3 and Routt No.4 respectively throughout this report. The Clay County portion of this project has met all legal, financial, and environmental requirements to drill and /or pump oil at this lease. We have also obtained all available information about this site and have taken the necessary steps to improve access roads, dig the necessary pits and build the necessary firewalls. Both wells have been drilled to the Salem formation. Gas gun technology was used to stimulate the reservoir of the Routt No.3. This report will address the technical aspects of the remediation.

  19. MEMORANDUM TO: FILE F3on: A 6 IL

    Office of Legacy Management (LM)

    .Z,+,ECI-INVOLVE?EXT AT SITE . ---... ---... ---- . 1, Control c Health Physics Protection . 0 AECMED managed operations G Little or None 3 AECtlED responsible for ...

  20. Snapshots of the IL-4 Receptor Ternary Complexes: An Opportunity...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    protein causing movements within the transmembrane region, which conveys the signal more directly across the membrane, where this latter mechanism is beyond the scope...

  1. MIN IMI IlI New Data Series

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Change, Petroleum Products Supplied, and Ending Stocks ... 40 3.1b Imports, Exports, and Net Imports ... 41 3.2 Crude Oil Supply and...

  2. QER Public Meeting in Chicago, IL: Rail, Barge, Truck Transportation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... (244.14 KB) John Gray, Senior Vice President for Policy and Economics, the Association of American Railroads (AAR) - Statement (592.32 KB) John Gray, Senior Vice President ...

  3. Quadrennial Energy Review Stakeholder Meeting #9: Chicago, IL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... energy resources as fuel for vehicles could be important. ... it has not received the traction it needs. 10 Q: What ... and transmission rural electric cooperative that serves ...

  4. Increasing Sugar Yields with IL-final-sm

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ionic Liquid Processing Increasing sugar yields from diverse biomass feedstock with ionic liquid processing and cultivation of renewable ionic liquids Liberating Sugars from Biomass Lignocellulose, one of the most abundant plants on Earth, has the potential to displace a substantial portion of the fossil fuels currently consumed within the transportation sector. Converting lignocellulose to biofuels requires the disruption of the lignin-carbohydrate complex within the plant and conversion into

  5. File:USDA-CE-Production-GIFmaps-KS.pdf | Open Energy Information

    Open Energy Info (EERE)

    KS.pdf Jump to: navigation, search File File history File usage Kansas Ethanol Plant Locations Size of this preview: 776 600 pixels. Full resolution (1,650 1,275 pixels,...

  6. Climate Action Champions: Mid-America Regional Council, KS and MO |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Mid-America Regional Council, KS and MO Climate Action Champions: Mid-America Regional Council, KS and MO The Mid-America Regional Council (MARC) is a nonprofit association of city and county governments and the metropolitan planning organization for the bistate Kansas City region. They provide a forum for the region to work together to advance social, economic and environmental progress. MARC received the Climate Action Champion designation in consortium with the City

  7. MARS-KS code validation activity through the atlas domestic standard problem

    SciTech Connect (OSTI)

    Choi, K. Y.; Kim, Y. S.; Kang, K. H.; Park, H. S.; Cho, S.

    2012-07-01

    The 2 nd Domestic Standard Problem (DSP-02) exercise using the ATLAS integral effect test data was executed to transfer the integral effect test data to domestic nuclear industries and to contribute to improving the safety analysis methodology for PWRs. A small break loss of coolant accident of a 6-inch break at the cold leg was determined as a target scenario by considering its technical importance and by incorporating interests from participants. Ten calculation results using MARS-KS code were collected, major prediction results were described qualitatively and code prediction accuracy was assessed quantitatively using the FFTBM. In addition, special code assessment activities were carried out to find out the area where the model improvement is required in the MARS-KS code. The lessons from this DSP-02 and recommendations to code developers are described in this paper. (authors)

  8. NREL Helps Greensburg, KS Launch GreenHome Partnership - News Releases |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NREL Helps Greensburg, KS Launch GreenHome Partnership KBIA's partnership with Greensburg is a model for communities needing to rebuild April 28, 2009 The U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL), in collaboration with the City Council of Greensburg, Kansas, and the Kansas Building Industry Association (KBIA), announce the launch of Greensburg GreenHome Residential Green Building Program. Greensburg GreenHome is a voluntary program with KBIA and supported

  9. Apc bridges Wnt/{beta}-catenin and BMP signaling during osteoblast differentiation of KS483 cells

    SciTech Connect (OSTI)

    Miclea, Razvan L.; Horst, Geertje van der; Robanus-Maandag, Els C.; Loewik, Clemens W.G.M.; Oostdijk, Wilma; Wit, Jan M.; Karperien, Marcel

    2011-06-10

    The canonical Wnt signaling pathway influences the differentiation of mesenchymal cell lineages in a quantitative and qualitative fashion depending on the dose of {beta}-catenin signaling. Adenomatous polyposis coli (Apc) is the critical intracellular regulator of {beta}-catenin turnover. To better understand the molecular mechanisms underlying the role of Apc in regulating the differentiation capacity of skeletal progenitor cells, we have knocked down Apc in the murine mesenchymal stem cell-like KS483 cells by stable expression of Apc-specific small interfering RNA. In routine culture, KSFrt-Apc{sub si} cells displayed a mesenchymal-like spindle shape morphology, exhibited markedly decreased proliferation and increased apoptosis. Apc knockdown resulted in upregulation of the Wnt/{beta}-catenin and the BMP/Smad signaling pathways, but osteogenic differentiation was completely inhibited. This effect could be rescued by adding high concentrations of BMP-7 to the differentiation medium. Furthermore, KSFrt-Apc{sub si} cells showed no potential to differentiate into chondrocytes or adipocytes. These results demonstrate that Apc is essential for the proliferation, survival and differentiation of KS483 cells. Apc knockdown blocks the osteogenic differentiation of skeletal progenitor cells, a process that can be overruled by high BMP signaling.

  10. NuSTAR DISCOVERY OF A CYCLOTRON LINE IN KS 1947+300

    SciTech Connect (OSTI)

    Fürst, Felix; Bellm, Eric; Harrison, Fiona; Walton, Dominic J.; Pottschmidt, Katja; Wilms, Jörn; Kennea, Jamie; Bachetti, Matteo; Boggs, Steven E.; Craig, William W.; Tomsick, John A.; Chakrabarty, Deepto; Christensen, Finn E.; Hailey, Charles J.; Stern, Daniel; Zhang, William

    2014-04-01

    We present a spectral analysis of three simultaneous Nuclear Spectroscopy Telescope Array and Swift/XRT observations of the transient Be-neutron star binary KS 1947+300 taken during its outburst in 2013/2014. These broadband observations were supported by Swift/XRT monitoring snapshots every three days, which we use to study the evolution of the spectrum over the outburst. We find strong changes of the power-law photon index, which shows a weak trend of softening with increasing X-ray flux. The neutron star shows very strong pulsations with a period of P ≈ 18.8 s. The 0.8-79 keV broadband spectrum can be described by a power law with an exponential cutoff and a blackbody component at low energies. During the second observation we detect a cyclotron resonant scattering feature at 12.5 keV, which is absent in the phase-averaged spectra of observations 1 and 3. Pulse phase-resolved spectroscopy reveals that the strength of the feature changes strongly with pulse phase and is most prominent during the broad minimum of the pulse profile. At the same phases the line also becomes visible in the first and third observation at the same energy. This discovery implies that KS 1947+300 has a magnetic field strength of B ≈ 1.1 × 10{sup 12}(1 + z) G, which is at the lower end of known cyclotron line sources.

  11. Effects of finite volume on the KL – KS mass difference

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Christ, N.  H.; Feng, X.; Martinelli, G.; Sachrajda, C.  T.

    2015-06-24

    Phenomena that involve two or more on-shell particles are particularly sensitive to the effects of finite volume and require special treatment when computed using lattice QCD. In this paper we generalize the results of Lüscher and Lellouch and Lüscher, which determine the leading-order effects of finite volume on the two-particle spectrum and two-particle decay amplitudes to determine the finite-volume effects in the second-order mixing of the K⁰ and K⁰⁻ states. We extend the methods of Kim, Sachrajda, and Sharpe to provide a direct, uniform treatment of these three, related, finite-volume corrections. In particular, the leading, finite-volume corrections to the KLmore » – KS mass difference ΔMK and the CP-violating parameter εK are determined, including the potentially large effects which can arise from the near degeneracy of the kaon mass and the energy of a finite-volume, two-pion state.« less

  12. AmeriFlux US-KS2 Kennedy Space Center (scrub oak)

    SciTech Connect (OSTI)

    Drake, Bert; Hinkle, Ross

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-KS2 Kennedy Space Center (scrub oak). Site Description - The Kennedy Space Center Scrub Oak site is located within the Merritt Island National Wildlife Refuge at the Kennedy Space Center (KSC) on the east coast of central Florida. Situated in a 10 ha scrub oak ecosystem, the surrounding stand was completely burned by a prescribed fire in 1996. The purpose of the burn was to control understory fuel load, which has been a common practice since 1969. Within a few weeks of the 1996 burn, the stand began to naturally regenerate from roots and rhizomes. Most scrub oak stands in the region undergo a 7 to 10 year disturbance cycle, mostly related to fire or hurricane activity. A severe drought gripped most of Florida beginning in 1998 until the later half of 2001 resulting in four years of relatively low amount of annual rainfall. Exceptionally high annual rainfall amount in 2004 was the result of a pair of hurricanes that hit the area in August and September of 2004. Prevaling wind directions for the site are as follows: W to NW in the winter, afternoon E sea breeze in the summer.

  13. untitled

    Gasoline and Diesel Fuel Update (EIA)

    2005 (Thousand Barrels) East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Liquefied Refinery Gases 382 8 390 2,072 157 116 2,345 EthaneEthylene 10...

  14. untitled

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    2005 (Thousand Barrels) East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Liquefied Refinery Gases 331 -18 313 2,398 -147 -220 2,031 EthaneEthylene...

  15. BPA-2014-00650-FOIA Response

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Charles Patrick "Pat" Roberts (R-KS, 1997-present) The office of Congressman Brad Schneider (D-IL, 2013-present) The office of Congressman John Tierney (D-MA, 1997-present) We...

  16. Airborne gamma-ray spectrometer and magnetometer survey, Belleville quadrangle (IL). Final report

    SciTech Connect (OSTI)

    Not Available

    1981-01-01

    Forty-two uranium anomalies meet the minimum statistical requirements as defined in Volume I. These anomalies are listed and are shown on the Uranium Anomaly Interpretation Map. Potassium (%K), equivalent Uranium (ppM eU), equivalent Thorium (ppM eTh), eU/eTh, eU/K, eTh/K, and magnetic pseudo-contour maps are presented in Appendix E. Stacked Profiles showing geologic strip maps along each flight-line, together with sensor data, and ancillary data are presented in Appendix F. All maps and profiles were prepared on a scale of 1:250,000, but have been reduced to 1:500,000 for presentation in Volume II. Anomalies No. 1, No. 4 to No. 17, No. 22 to No. 23, and No. 27 to No. 30 are over areas underlain by the Radnor Till member (Qti) of the Pleistocene Glasford formation. Anomalies No. 2 and No. 3 are over areas underlain by Pleistocene Cahokia Alluvium (Qc) and the Radnor Till member (Qti) of the Glasford formation. Anomalies No. 18 to No. 21, and No. 24 are over areas underlain by the Pleistocene Equality formation (Qcl). Anomalies No. 25 and No. 26 are over areas underlain by the Equality formation (Qcl) and the Radnor Till member (Qti) of the Glasford formation. Both of these formations are of Pleistocene age. Anomalies No. 31 and No. 33 are over areas underlain by the Pleistocene Cahokia Alluvium (Qc). Anomalies No. 32, No. 34 to No. 38, and No. 40 to No. 42 are over areas underlain by the Radnor Till member (Qti) of the Pleistocene Glasford formation. Anomaly No. 39 is over an area underlain by the Radnor Till (Qti) and the Hagarstown (Qgh) members of the Pleistocene Glasford formation.

  17. Airborne gamma-ray spectrometer and magnetometer survey: Peoria, Decater, Belleville Quadrangles, (IL). Final report

    SciTech Connect (OSTI)

    Not Available

    1981-01-01

    An airborne combined radiometric and magnetic survey was performed for the Department of Energy (DOE) over the area covered by the Peoria, Decatur, and Belleville, 1:250,000 National Topographic Map Series (NTMS), quadrangle maps. The survey was part of DOE's National Uranium Resource Evaluation (NURE) program. Data were collected by a helicopter equipped with a gamma-ray spectrometer with a large crystal volume, and with a high sensitivity proton procession magnetometer. The radiometric system was calibrated at the Walker Field Calibration pads and the Lake Mead Dynamic Test Range. Data quality was ensured during the survey by daily test flights and equipment checks. Radiometric data were corrected for live time, aircraft and equipment background, cosmic background, atmospheric radon, Compton scatter, and altitude dependence. The corrected data were statistically evaluated, plotted, and contoured to produce anomaly maps based on the radiometric response of individual geological units. The anomalies were interpreted and an interpretation map produced. Volume I contains a description of the systems used in the survey, a discussion of the calibration of the systems, the data collection procedures, the data processing procedures, the data presentation, the interpretation rationale, and the interpretation methodology. A separate Volume II for each quadrangle contains the data displays and the interpretation results.

  18. 4-27-11-signed-Final-EA-FONSI-for-BeaconPower--IL-PA-.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

  19. Il,R!:i'iT[ WORKING GROUP Final Report of the Oak Ridge Reservation

    Office of Environmental Management (EM)

    Exchange Membrane Fuel Cell Markets | Department of Energy Identification and Characterization of Near-Term Direct Hydrogen Proton Exchange Membrane Fuel Cell Markets Identification and Characterization of Near-Term Direct Hydrogen Proton Exchange Membrane Fuel Cell Markets This document provides information about near-term markets (such as for forklifts and telecommunications) for proton exchange membrane fuel cells. pemfc_econ_2006_report_final_0407.pdf (3.88 MB) More Documents &

  20. Preliminary evaluation of a fluorescence and radioisotope nuclear smuggling deterrence tag - final report (IL500E)

    SciTech Connect (OSTI)

    Hartenstein, S.D.; Aryaeinejad, R.; Delmastro, J.R.

    1997-04-01

    This report summarizes the efforts completed in identifying candidate fluorescence compounds and radioisotopes for a developing tagging system. The tagging system is being developed as a deterrent to nuclear smuggling, by providing a means of: (1) tracing materials and pilferers to the facility of origin for any recovered special nuclear materials, (2) inventory control of long-term stored items containing special nuclear materials, and (3) tracking materials transferred between facilities. The system uses three types of materials to cover a range of applications intended to prevent the pilfering of special nuclear materials. One material, fluorescent compounds which are invisible without ultraviolet or near-infrared detection systems, is marked on controlled items with a tracking pattern that corresponds to a specified item in a specified location in the data control system. The tagging system uses an invisible, fluorescent dusting powder to mark equipment and personnel who inappropriately handle the tagged material. The tagging system also uses unique combinations of radionuclides to identify the facility of origin for any special nuclear material. This report also summarizes the efforts completed in identifying hardware that will be used for the tagging system. This hardware includes the devices for applying the tagging materials, the commercially available fluorescence detection systems, and gamma ray detection systems assembled from existing, commercially available technologies.

  1. ORNLIRASA-S9Il9 HEALTH m SAFETY RESEARCH DMSION I Environmental...

    Office of Legacy Management (LM)

    Inc.. employee ' U.S. Department of Energy 1F' ork performed by the hIEASUREMEKT APPLICATIONS z41m DETLOPMENT GROUP Prepared by the OAK RIDGE NATIONAL LABORATORY Oak Ridge, ...

  2. Impacts of antropogenic contaminants on vegetation and groundwater chemistry in a fen complex (IL)

    SciTech Connect (OSTI)

    Nuzzo, V.A.; Hensel, B.; Panno, S.; Cartwright, K.; Krapac, I. Illinois State Geological Survey, Champaign )

    1993-06-01

    Residential development within the watershed of a fen complex has resulted in encroachment of ground-water borne anthropogenic contaminants into 3 high quality fens. Groundwater samples were collected from peat and marl and analyzed for inorganic constituents. Height and density of Typha angustifolia L. and Scirpus acutus Muhl. were recorded in belt transects coincident with ground-water samples. Contaminant plumes from septic systems of houses near the fens had higher Na, Cl, NO[sub 3], and TDS levels than uncontaminated areas of the fens. Typha density increased significantly as Na, Cl, CL/SO[sub 4], and TDS levels increased; Scirpus occurred only where pH [ge] 7.1 (X[sub 2]=11.656, sl=.02). Scirpus density was generally independent of other water chemistry levels. In one fen Scirpus density declined significantly as Typha density increased (r[sub 2]=25.86). Contamination appears to favor Tvpha invasion, which subsequently leads to displacement of Scirpus.

  3. EA-1975: LINAC Coherent Light Source-Il, SLAC National Accelerator Laboratory, Menlo Park, California

    Broader source: Energy.gov [DOE]

    DOE prepared an EA on the potential environmental impacts of a proposal to upgrade the existing LINAC Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory. The proposed LCLS-II would extend the photon energy range, increase control over photon pulses, and enable two-color pump-probe experiments. The X-ray laser beams generated by LCLS-II would enable a new class of experiments: the simultaneous investigation of a material’s electronic and structural properties.

  4. DOE ZERH Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    SciTech Connect (OSTI)

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning production home in the cold climate that got a HERS 38 without PV, with staggered 2x4 studs every 8”on a 2x6 plate with dense-packed R-25 cellulose, basement with 3” XPS exterior and 2: XPS under slab; a vented attic with spray foam top plates and R-60 blown cellulose; 96% AFUE furnace, 14 SEER AC, plus fresh air intake.

  5. DOE ZERH Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL

    SciTech Connect (OSTI)

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning custom home in the cold climate that got a HERS 30 without PV, with 2x8 24” on center walls with blown fiberglass and 4” polysio rigid foam; basement with 2” XPS interior, 4” under slab, 4” exterior of foundation wall; vented attic with R-100 blown cellulose; wo air-to-air heat pumps SEER 14.1; HSPF 9.6; heat pump water heater.

  6. AmeriFlux US-KS1 Kennedy Space Center (slash pine)

    SciTech Connect (OSTI)

    Drake, Bert; Hinkle, Ross

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-KS1 Kennedy Space Center (slash pine). Site Description - The Kennedy Space Center Slash Pine Flatwoods site is located in the Merritt Island National Wildlife Refuge at the Kennedy Space Center (KSC) on the east coast of central Florida. Occupying 310 ha of local forest, the slash pine flatwoods ecosystem is managed as an uneven-aged stand with a sparsely populated overstory and a dense oak-dominated understory. Disturbances tend to occur on a 7 to 10 year cycle, mostly related to fire or hurricane activity. Prescribed fires have been conducted since 1969 to control understory fuel. The most recent burn was conducted in February of 1995. Following the burn, the stand was allowed to naturally regenerate into a open canopy of slash pines, less than 15% of canopy coverage ( on the order of 15-30 trees per ha), with a understory mostly composed of saw palmetto and scrub oak. There was a seasonally wet swale to the southeast that was on the margin of the flux tower footprint. A severe drought gripped most of Florida beginning in 1998 until the later half of 2001 resulting in four years of relatively low annual precipitation totals. Exceptionally high annual rainfall amounts in 2004 were the result of a pair of hurricanes that hit the area in August and September of 2004. Wind directions for the site are as follows: W and NW in the winter, afternoon E sea breeze in the summer.

  7. Observation of a narrow structure in 1 H( γ , KS0 ) X via interference with φ -meson production

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Amaryan, M. J.; Gavalian, G.; Nepali, C.; Polyakov, M. V.; Azimov, Ya.; Briscoe, W. J.; Dodge, G. E.; Hyde, C. E.; Klein, F.; Kuznetsov, V.; et al

    2012-03-01

    We report observation of a narrow peak structure at ≈1.54 GeV with a Gaussian width σ = 6 MeV in the missing mass of KS in the reaction γ + p → pKSKL. The observed structure may be due to the interference between a strange (or antistrange) baryon resonance in the pKL system and the φ(KSKL) photoproduction leading to the same final state. The statistical significance of the observed excess of events estimated as the log-likelihood ratio of the resonant signal + background hypothesis and the φ-production-based background-only hypothesis corresponds to 5.3σ.

  8. Observation of a narrow structure in 1H(?,KS0)X via interference with phi-meson production

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Amaryan, M J; Nepali, C; Polyakov, M V; Azimov, Ya; Briscoe, W J; Dodge, G E; Hyde, C E; Klein, F; Kuznetsov, V; Strakovsky, I

    2012-03-21

    We report observation of a narrow peak structure at ?1.54 GeV with a Gaussian width ? = 6 MeV in the missing mass of KS in the reaction ? + p ? pKSKL. The observed structure may be due to the interference between a strange (or antistrange) baryon resonance in the pKL system and the ?(KSKL) photoproduction leading to the same final state. The statistical significance of the observed excess of events estimated as the log-likelihood ratio of the resonant signal + background hypothesis and the ?-production-based background-only hypothesis corresponds to 5.3?.

  9. Cover Title Here

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Station Canton, IL Edwards Power Station Bartonville, IL Joppa Power Station Joppa, IL Newton Power Station Jasper County, IL MISO (CoalCo) Baldwin Energy Complex Baldwin, IL ...

  10. RELAP5/MOD3.2 Assessment Using CHF Data from the KS-1 and V-200 Experiment Facilities

    SciTech Connect (OSTI)

    Bayless, Paul David

    2001-07-01

    The RELAP/MOD3.2 computer code has been assessed using rod bundle critical heat flux data from the KS-1 and V-200 facilities. This work was performed as part of the U.S. Department of Energy’s International Nuclear Safety Program, and is part of the effort addressing the capability of the RELAP5/MOD3.2 code to model transients in Soviet-designed reactors. Designated VVER Standard Problem 7, these tests addressed one of the important phenomena related to VVER behavior that the code needs to simulate well, core heat transfer. The code was judged to be in minimal agreement with the experiment data, consistently overpredicting the measured critical heat flux. It is recommended that a model development effort be undertaken to develop a critical heat flux model for RELAP5 that better represents the behavior in VVER rod bundles.

  11. CONTINUED COOLING OF THE CRUST IN THE NEUTRON STAR LOW-MASS X-RAY BINARY KS 1731-260

    SciTech Connect (OSTI)

    Cackett, Edward M.; Miller, Jon M.; Brown, Edward F.; Cumming, Andrew; Degenaar, Nathalie; Wijnands, Rudy

    2010-10-20

    Some neutron star low-mass X-ray binaries have very long outbursts (lasting several years) which can generate a significant amount of heat in the neutron star crust. After the system has returned to quiescence, the crust then thermally relaxes. This provides a rare opportunity to study the thermal properties of neutron star crusts, putting constraints on the thermal conductivity and hence the structure and composition of the crust. KS 1731-260 is one of only four systems where this crustal cooling has been observed. Here, we present a new Chandra observation of this source approximately eight years after the end of the last outburst and four years since the last observation. We find that the source has continued to cool, with the cooling curve displaying a simple power-law decay. This suggests that the crust has not fully thermally relaxed yet and may continue to cool further. A simple power-law decay is in contrast to theoretical cooling models of the crust, which predict that the crust should now have cooled to the same temperature as the neutron star core.

  12. Technical description of candidate fluorescence compounds and radioisotopes for a nuclear smuggling deterrence tag (IL500E)

    SciTech Connect (OSTI)

    Hartenstein, S.D.; Aryaeinejad, R.

    1996-03-01

    This report summarizes the efforts completed in identifying candidate fluorescence compounds and radioisotopes for a developing tagging system. The tagging system is being developed as a deterrent to nuclear smuggling, by providing a means of: (1) tracing materials and pilferers to the facility of origin for any recovered special nuclear materials; (2) inventory control of long-term stored items containing special nuclear materials; and (3) tracking materials transferred between facilities. The tagging system uses four types of tagging materials to cover a range of applications intended to prevent the pilfering of special nuclear materials. One material, fluorescent compounds which are invisible without ultraviolet or near-infrared detection systems, is marked on controlled items with a tracking pattern that corresponds to a specified item in a specified location in the data control system. The tagging system uses an invisible, fluorescent dusting powder to mark equipment and personnel who inappropriately handle the tagged material. The tagging system also uses unique combinations of radionuclides to identify the facility of origin for any special nuclear material. Currently, 18 long-lived radioisotopes, 38 short-live radioisotopes and 10 fluorescent compounds have been selected as candidate materials for the tagging system.

  13. DOE Zero Energy Ready Home Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    Broader source: Energy.gov [DOE]

    Case study of a DOE 2015 Housing Innovation Award winning production home in the cold climate that got a HERS 38 without PV, with staggered 2x4 studs every 8”on a 2x6 plate with dense-packed R-25 cellulose, basement with 3” XPS exterior and 2: XPS under slab; a vented attic with spray foam top plates and R-60 blown cellulose; 96% AFUE furnace, 14 SEER AC, plus fresh air intake.

  14. Natural Gas and Hydrogen Infrastructure Opportunities Workshop, October 18-19, 2011, Argonne National Laboratory, Argonne, IL : Summary Report.

    SciTech Connect (OSTI)

    Kumar, R. comp.; Ahmed, S. comp.

    2012-02-21

    The overall objective of the Workshop was to identify opportunities for accelerating the use of both natural gas (NG) and hydrogen (H{sub 2}) as motor fuels and in stationary power applications. Specific objectives of the Workshop were to: (1) Convene industry and other stakeholders to share current status/state-of-the-art of NG and H{sub 2} infrastructure; (2) Identify key challenges (including non-technical challenges, such as permitting, installation, codes, and standards) preventing or delaying the widespread deployment of NG and H{sub 2} infrastructure. Identify synergies between NG and H{sub 2} fuels; and (3) Identify and prioritize opportunities for addressing the challenges identified above, and determine roles and opportunities for both the government and industry stakeholders. Plenary speakers and panel discussions summarized the current status of the NG and H{sub 2} infrastructure, technology for their use in transportation and stationary applications, and some of the major challenges and opportunities to more widespread use of these fuels. Two break-out sessions of three groups each addressed focus questions on: (1) infrastructure development needs; (2) deployment synergies; (3) natural gas and fuel cell vehicles (NGVs, FCVs), specialty vehicles, and heavy-duty trucks; (4) CHP (combined heat and power), CHHP (combined hydrogen, heat, and power), and synergistic approaches; and (5) alternative uses of natural gas.

  15. Origin State>> CA CA ID ID ID IL KY MD MO NM NM NY NY OH SC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MO NM NM NY NY OH SC TN TN TN, WA, CA TN TN TN TN Total Shipments by Route Lawrence Livermore National Laboratory General Atomics Batelle Energy Alliance Idaho National Laboratory Advanced Mixed Waste Treatment Project Argonne National Laboratory Paducah Gaseous Diffusion Plant Aberdeen Proving Grounds National Security Technologies Sandia National Laboratory Los Alamos National Laboratory Brookhaven National Laboratory CH2M Hill B&W West Valley, LLC Portsmouth Gaseous Diffusion Plant

  16. Origin State>> CA CA ID ID ID IL KY MD NM NM NV NY NY OH TN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NM NM NV NY NY OH TN TN TN, WA, CA TN TN TN TN TX Total Shipments by Route Lawrence Livermore National Laboratory General Atomics Advanced Mixed Waste Treatment Project Batelle Energy Alliance Idaho National Laboratory Argonne National Laboratory Paducah Gaseous Diffusion Plant Aberdeen Proving Ground Los Alamos National Laboratory Sandia National Laboratory National Security Technologies Brookhaven National Laboratory West Valley Environmental Services Portsmouth Gaseous Diffusion Plant

  17. Origin State>> CA CA ID ID IL KY NJ NM NY NY NV OH OH OH SC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mix Wastew Treatment Project Argonne National Laboratory Paducah Gaseous Diffusion Plant Princeton Plasma Physics Laboratory Sandia National Laboratory Brookhaven National Laboratory West Valley Demonstration Project National Security Technologies, Inc. Mound Closure Project Portsmouth Gaseous Diffusion Plant Fernald Closure Project Savannah River Site BWXT Y-12 Plant Duratek Nuclear Fuels UT-Battelle Bechtel Jacobs Permafix M&EC EnergX (Foster Wheeler) Pantex Plant SOUTHERN I-15, CA-127,

  18. Origin State>> CA CA ID ID IL KY NJ NM NY NY NV OH OH OH SC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mixed Waste Treatment Project Argonne National Laboratory Paducah Gaseous Diffusion Plant Princeton Plasma Physics Laboratory Sandia National Laboratory Brookhaven National Laboratory West Valley Demonstration Project National Security Technologies, Inc. Mound Closure Project Portsmouth Gaseous Diffusion Plant Fernald Closure Project Savannah River Site BWXT Y-12 Plant Duratek Nuclear Fuels UT-Battelle Bechtel Jacobs Permafix M&EC EnergX (formerly Foster Wheeler) Pantex Plant SOUTHERN I-15,

  19. Origin State>> CA CA ID ID IL KY NJ NM NY NY NV OH OH SC TN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SC TN TN TN TN TN TN TN TX Total Shipments by Route Lawrence Livermore National Laboratory Boeing/Rocketdyne Idaho National Labaratoy Advanced Mixed Waste Treatment Project Argonne National Laboratory Paducah Gaseous Diffusion Plant Princeton Plasma Physics Laboratory Sandia National Laboratory Brookhaven National Laboratory West Valley Demonstration Project National Security Technologies, Inc. Portsmouth Gaseous Diffusion Plant Fernald Closure Project Savannah River Site BWXT Y-12 Plant Duratek

  20. Origin State>> CA ID ID ID IL KY MD NM NM NY NY OH SC TN TN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MD NM NM NY NY OH SC TN TN TN, WA, CA TN TN TN TN TX Total Shipments by Route Lawrence Livermore National Laboratory Advanced Mixed Waste Treatment Project Batelle Energy Alliance Idaho National Laboratory Argonne National Laboratory Paducah Gaseous Diffusion Plant Aberdeen Proving Ground Los Alamos National Laboratory Sandia National Laboratory Brookhaven National Laboratory West Valley Environmental Services Portsmouth Gaseous Diffusion Plant Savannah River Site Duratek/Energy Solutions Babcox

  1. Origin State>> CA ID ID ID IL KY NV NY NY OH TN TN TN, WA, CA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NV NY NY OH TN TN TN, WA, CA TN TN TN TN TX Total Shipments by Route Lawrence Livermore National Laboratory Advanced Mixed Waste Treatment Project Batelle Energy Alliance Idaho National Laboratory Argonne National Laboratory Paducah Gaseous Diffusion Plant National Security Technologies Brookhaven National Laboratory West Valley Environmental Services Portsmouth Gaseous Diffusion Plant Duratek/Energy Solutions Babcox & Wilcox Technical Services Y-12 Plant Materials & Energy Corporation

  2. Origin State>> CA ID ID ID IL MD NM NM NV NY NY OH SC TN TN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NV NY NY OH SC TN TN TN, WA, CA TN TN TN Total Shipments by Route Lawrence Livermore National Laboratory Batelle Energy Alliance Idaho National Laboratory Advanced Mixed Waste Treatment Project Argonne National Laboratory Aberdeen Proving Ground Sandia National Laboratory Los Alamos National Laboratory National Security Technologies Brookhaven National Laboratory West Valley Environmental Services Portsmouth Gaseous Diffusion Plant Savannah River Site Duratek/Energy Solutions Babcox & Wilcox

  3. Origin State>> CA ID ID ID IL MD NM NM NY OH TN TN TN, WA, CA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NY OH TN TN TN, WA, CA TN TN TN TX Total Shipments by Route Lawrence Livermore National Laboratory Batelle Energy Alliance Idaho National Laboratory Advanced Mixed Waste Treatment Project Argonne National Laboratory Aberdeen Proving Ground Sandia National Laboratory Los Alamos National Laboratory Brookhaven National Laboratory Portsmouth Gaseous Diffusion Plant Duratek/Energy Solutions Babcox & Wilcox Technical Services Y-12 Plant Materials & Energy Corporation (M&EC) Perma-Fix

  4. Origin State>> CA ID ID ID IL NM NM OH TN TN TN, WA, CA TN TN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NM NM OH TN TN TN, WA, CA TN TN TN TN TX Total Shipments by Route Lawrence Livermore National Laboratory Batelle Energy Alliance Idaho National Laboratory Advanced Mixed Waste Treatment Project Argonne National Laboratory Sandia National Laboratory Los Alamos National Laboratory Portsmouth Gaseous Diffusion Plant Duratek/Energy Solutions Babcox & Wilcox Technical Services Y-12 Plant Materials & Energy Corporation (M&EC) Perma-Fix Nuclear Fuels Services Wastren Advantage, Inc.

  5. New Whole-House Solutions Case Study: Meeting DOE Challenge Home Program Certification - Chicago, IL; Denver, CO; Devens, MA

    SciTech Connect (OSTI)

    2015-01-01

    In this project, three production home builders—K. Hovnanian Homes, David Weekley Homes, and Transformations, Inc.—partnered with Building America team Building Science Corporation to evaluate the certification of five test homes to the new DOE Challenge Home program performance standard (now DOE Zero Energy Ready Home program). The builders identified key benefits and barriers that impacted the certification of the test homes, and the likelihood of whether DOE Challenge Home certification would be pursued in future homes

  6. Workbook Contents

    U.S. Energy Information Administration (EIA) Indexed Site

    Storage Capacity (Summary) " "Sourcekey","N5290US2","N5290AL2","NGMEPG0SACSALMMCF","N5290AR2","N5290CA2","N5290CO2","N5290IL2","N5290IN2","N5290IA2","N5290KS2","N529...

  7. PSA Vol 1 Tables Revised Ver 2 Print.xls

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    2005 (Thousand Barrels) East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Liquefied Refinery Gases 14,825 298 15,123 33,928 1,840 2,446 38,214...

  8. untitled

    Gasoline and Diesel Fuel Update (EIA)

    2005 (Thousand Barrels) East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Total Net Input 16,465 108 16,573 10,405 2,208 1,923 14,536 Pentanes Plus...

  9. PSA Vol 1 Tables Revised Ver 2 Print.xls

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    2005 (Thousand Barrels) East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Natural Gas Liquids 359 5,914 6,273 26,874 4,786 77,174 108,834 Pentanes...

  10. PSA Vol 1 Tables Revised Ver 2 Print.xls

    Gasoline and Diesel Fuel Update (EIA)

    Refining Districts, 2005 East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Liquefied Refinery Gases 2.5 0.9 2.4 4.2 1.2 0.9 3.1 Finished Motor...

  11. untitled

    Gasoline and Diesel Fuel Update (EIA)

    2005 (Thousand Barrels) East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Total Net Input 17,809 97 17,906 9,452 1,740 1,790 12,982 Pentanes Plus 0...

  12. untitled

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    2005 (Thousand Barrels) East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Natural Gas Liquids 44 526 570 1,615 417 5,414 7,446 Pentanes Plus 5 89 94...

  13. F-1 U.S. Energy Information Administration | Annual Energy Outlook...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Central West North Central East North Central Mountain AK WA MT WY ID NV UT CO AZ NM TX OK IA KS MO IL IN KY TN MS AL FL GA SC NC WV PA NJ MD DE NY CT VT ME RI MA NH VA WI MI OH...

  14. PSA Vol 1 Tables Revised Ver 2 Print.xls

    Gasoline and Diesel Fuel Update (EIA)

    2005 (Thousand Barrels) East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Total Net Input 199,173 1,285 200,458 117,409 24,041 20,032 161,482...

  15. untitled

    Gasoline and Diesel Fuel Update (EIA)

    December 2005 East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Liquefied Refinery Gases 0.7 -0.6 0.6 3.5 -1.1 -1.0 1.9 Finished Motor Gasoline a 50.3...

  16. untitled

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    2005 (Thousand Barrels) East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Natural Gas Liquids 0 508 508 2,142 393 6,367 8,902 Pentanes Plus 0 90 90...

  17. F-5 U.S. Energy Information Administration | Annual Energy Outlook...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Figure F4. Oil and Gas Supply Model Regions Atlantic WA MT WY ID NV UT CO AZ NM TX OK IA KS MO IL IN KY TN MS AL FL GA SC NC WV PA NJ MD DE NY CT ME RI MA NH VA WI MI OH NE...

  18. untitled

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    September 2005 East Coast Appalachian No. 1 Total IN, IL, KY MN, WI, ND, SD OK, KS, MO Total Liquefied Refinery Gases 0.7 0.3 0.7 2.9 1.3 0.5 2.2 Finished Motor Gasoline a 47.9...

  19. Acoustic Building Infiltration Measurement System (ABIMS)

    Office of Energy Efficiency and Renewable Energy (EERE)

    Lead Performer: Argonne National Laboratory - Lemont, IL Partner: Illinois Institute of Technology - Chicago, IL

  20. Workplace Charging Challenge Partner: Township High School District 214

    Broader source: Energy.gov [DOE]

    Joined the Challenge: October 2014Headquarters: Arlington Heights, ILCharging Locations: Arlington Heights, IL; Buffalo Grove, IL; Elk Grove Village, IL; Mount Prospect, IL; Rolling Meadows, IL;...

  1. SU-E-T-625: Use and Choice of Ionization Chambers for the Commissioning of Flattened and Flattening-Filter-Free Photon Beams: Determination of Recombination Correction Factor (ks)

    SciTech Connect (OSTI)

    Stucchi, C; Mongioj, V; Carrara, M; Pignoli, E; Bonfantini, F; Bresolin, A

    2014-06-15

    Purpose: To evaluate the recombination effect for some ionization chambers to be used for linacs commissioning for Flattened Filter (FF) and Flattening Filter Free (FFF) photon beams. Methods: A Varian TrueBeam linac with five photon beams was used: 6, 10 and 15 MV FF and 6 and 10 MV FFF. Measurements were performed in a water tank and in a plastic water phantom with different chambers: a mini-ion chamber (IC CC01, IBA), a plane-parallel ion chamber (IC PPC05, IBA) and two Farmer chambers (NE2581 and FPC05-IBA). Measurement conditions were Source- Surface Distance of 100 cm, two field sizes (10x10 and 40x40 cm2) and five depths (1cm, maximum buildup, 5cm, 10cm and 20cm). The ion recombination factors (kS), obtained from the Jaffe's plots (voltage interval 50-400 V), were evaluated at the recommended operating voltage of +300V. Results: Dose Per Pulse (DPP) at dmax was 0.4 mGy/pulse for FF beams, 1.0 mGy/pulse and 1.9 mGy/pulse for 6MV and 10 MV FFF beams respectively. For all measurement conditions, kS ranged between 0.996 and 0.999 for IC PPC05, 0.997 and 1.008 for IC CC01. For the FPC05 IBA Farmer IC, kS varied from 1.001 to 1.011 for FF beams, from 1.004 to 1.015 for 6 MV FFF and from 1.009 to 1.025 for 10 MV FFF. Whereas, for NE2581 IC the values ranged from 1.002 to 1.009 for all energy beams and measurement conditions. Conclusion: kS depends on the chamber volume and the DPP, which in turn depends on energy beam but is independent of dose rate. Ion chambers with small active volume can be reliably used for dosimetry of FF and FFF beams even without kS correction. On the contrary, for absolute dosimetry of FFF beams by Farmer ICs it is necessary to evaluate and apply the kS correction. Partially supported by Lega Italiana Lotta contro i Tumori (LILT)

  2. Luminescent host–guest materials of electrostatically adsorbed Eu{sup 3+}(tta){sub 3}-tpyIL on zeolite L crystals

    SciTech Connect (OSTI)

    Li, Peng; Wang, Dongyue; Liang, Dong; Zhang, Li; Zhang, Shuming; Wang, Yige

    2014-07-01

    Graphical abstract: Luminescent host–guest materials exhibiting tunable emission colors by changing the excitation wavelength are obtained by surface modification of terbium(III) bipyridine-loaded zeolite L crystals with the ionic europium(III) complexes. - Highlights: • Luminescent ionic europium(III) complex was synthesized. • Outer surface of zeolite L was modified by electrostatic adsorption of the ionic complex. • Luminescent host–guest material with tunable emission color was obtained. - Abstract: The surface modification of zeolite L crystals with lanthanide complexes was achieved by electrostatic adsorption of ionic europium(III) complexes that are prepared by the reaction of tris(2-thenoyltrifluoroacetonate) europium(III) dehydrate with an organic salt containing terpyridine moieties on the negative charge-bearing surfaces of zeolite L crystals. Luminescent host–guest materials exhibiting tunable emission colors by changing the excitation wavelength are obtained by surface modification of terbium(III) bipyridine-loaded zeolite L crystals with the ionic europium(III) complexes.

  3. Instabilities and chaos in quantum optics II; Proceedings of the NATO Advanced Study Institute, Il Ciocco, Italy, June 28-July 7, 1987

    SciTech Connect (OSTI)

    Abraham, N.B.; Arecchi, F.T.; Lugiato, L.A.

    1988-01-01

    The following topics are considered: laser and maser instabilities, classical and quantum noise, transverse effects, dynamics in optical bistability and nonlinear optical media, and methods of analysis in nonlinear dynamics. Particular papers are presented on multistability and chaos in a two-photon microscopic maser, quantum chaos in quantum optics, spatial chaos in bistable optical arrays, four-wave mixing and dynamics, and bifurcation problems in nonlinear optics.

  4. Heat transfer in ocean thermal energy conversion (OTEC) systems. Proceedings of the wanter mnnual Meeting, Chicago, IL, November 16-21, 1980

    SciTech Connect (OSTI)

    Owens, W.L.

    1980-01-01

    Among the topics discussed are: condensation heat transfer on long vertical, axially ridged tubes tests of the Applied Physics Laboratory of Johns Hopkins University (APL/JHU) folded-tube, Ocean Thermal Energy Conversion (OTEC) heat exchanger the design of a 1.0-MW OTEC heat exchanger for ocean testing and convective vaporization and condensation in serrated-fin channels. Also considered are: heat tranfer studies of an improved heat transfer monitor for OTEC an analysis of the mist lift process for mist flow, open-cycle OTEC the heat transfer characteristics of working fluids for OTEC and a comparison of major OTEC power system characteristics.

  5. Biogas and alcohol fuels production. Proceedings of the Seminar on Biomass, Energy for City, Farm, and Industry, Chicago, IL, October 25, 26, 1979

    SciTech Connect (OSTI)

    Goldstein, J.

    1980-01-01

    Basic principles of anaerobic digestion are considered along with the status of the Imperial Valley Biogas Project, the Department of Energy program for the recovery of energy and materials from urban waste, the principles of alcohol production from wastes, the mechanical recovery of a refuse-derived cellulosic feedstock for ethanol production, and the production of ethanol from cellulosic biomass. Attention is given to on-farm alcohol fuel production, the current status and future role of gasohol production, methane generation from small scale farms, farmsite installations of energy harvester anaerobic digesters, biogas/composting and landfill recovery, farm-scale composting as an option to anaerobic digestion, designing a high-quality biogas system, and methane as fuel of the future. A description is presented of subjects which are related to landfill gas recovery, biogas purification with permselective membranes, and anaerobic digestion of marine biomass. Other topics studied include the application of biogas technology in India, biogas production in China, biogasification of organic wastes in the Republic of the Philippines, and economics and operational experience of full-scale anaerobic dairy manure digester.

  6. Athletic equipment microbiota are shaped by interactions with...

    Office of Scientific and Technical Information (OSTI)

    Chicago, IL (United States) Argonne National Lab. (ANL), Lemont, IL (United States) MO BIO Lab., Inc., Carlsbad, CA (United States) Argonne National Lab. (ANL), Lemont, IL (United ...

  7. Spin Hall effects in metallic antiferromagnets - perspectives...

    Office of Scientific and Technical Information (OSTI)

    60439, USA, Department of Physics and Astronomy, Northwestern University, Evanston IL ... IL 60616, USA Department of Physics and Astronomy, Northwestern University, Evanston IL ...

  8. Energy Savings with Acceptable Indoor Air Quality Through Improved Air Flow Control in Residential Retrofit

    Office of Energy Efficiency and Renewable Energy (EERE)

    Lead Performer: Gas Technology Institute—Des Plaines, IL Partners: -- University of Illinois, Urbana IL -- Midwest Energy Efficiency Alliance, Chicago IL

  9. Amplitude Analysis and Measurement of the Time-dependent CP Asymmetry of B0 to KsKsKs Decays

    SciTech Connect (OSTI)

    Lees, J.P.

    2012-04-11

    We present the first results on the Dalitz-plot structure and improved measurements of the time-dependent CP-violation parameters of the process B{sup 0} {yields} K{sub S}{sup 0}K{sub S}{sup 0}K{sub S}{sup 0} obtained using 468 x 10{sup 6} B{bar B} decays collected with the BABAR detector at the PEP-II asymmetric-energy B factory at SLAC. The Dalitz-plot structure is probed by a time-integrated amplitude analysis that does not distinguish between B{sup 0} and {bar B}{sup 0} decays. We measure the total inclusive branching fraction {Beta}(B{sup 0} {yields} K{sub S}{sup 0}K{sub S}{sup 0}K{sub S}{sup 0}) = (6.19 {+-} 0.48 {+-} 0.15 {+-} 0.12) x 10{sup -6}, where the first uncertainty is statistical, the second is systematic, and the third represents the Dalitz-plot signal model dependence. We also observe evidence for the intermediate resonant states f{sub 0}(980), f{sub 0}(1710), and f{sub 2}(2010). Their respective product branching fractions are measured to be (2.70{sub -1.19}{sup +1.25} {+-} 0.36 {+-} 1.17) x 10{sup -6}, (0.50{sub -0.24}{sup +0.46} {+-} 0.04 {+-} 0.10) x 10{sup -6}, and (0.54{sub -0.20}{sup +0.21} {+-} 0.03 {+-} 0.52) x 10{sup -6}. Additionally, we determine the mixing-induced CP-violation parameters to be S = -0.94{sub -0.21}{sup +0.24} {+-} 0.06 and C = -0.17 {+-} 0.18 {+-} 0.04, where the first uncertainty is statistical and the second is systematic. These values are in agreement with the standard model expectation.

  10. Ks-BAND DETECTION OF THERMAL EMISSION AND COLOR CONSTRAINTS TO CoRoT-1b: A LOW-ALBEDO PLANET WITH INEFFICIENT ATMOSPHERIC ENERGY REDISTRIBUTION AND A TEMPERATURE INVERSION

    SciTech Connect (OSTI)

    Rogers, Justin C.; Apai, Daniel; Lopez-Morales, Mercedes; Sing, David K.; Burrows, Adam

    2009-12-20

    We report the detection in Ks-band of the secondary eclipse of the hot Jupiter CoRoT-1b from time series photometry with the ARC 3.5 m telescope at Apache Point Observatory. The eclipse shows a depth of 0.336 +- 0.042% and is centered at phase 0.5022{sup +0.0023}{sub -0.0027}, consistent with a zero eccentricity orbit (e cos omega = 0.0035{sup +0.0036}{sub -0.0042}). We perform the first optical to near-infrared multi-band photometric analysis of an exoplanet's atmosphere and constrain the reflected and thermal emissions by combining our result with the recent 0.6, 0.71, and 2.09 mum secondary eclipse detections by Snellen et al., Gillon et al., and Alonso et al. Comparing the multi-wavelength detections to state-of-the-art radiative-convective chemical-equilibrium atmosphere models, we find the near-infrared fluxes difficult to reproduce. The closest blackbody-based and physical models provide the following atmosphere parameters: a temperature T = 2460{sup +80}{sub -160} K; a very low Bond albedo A{sub B} = 0.000{sup +0.081}{sub -0.000}; and an energy redistribution parameter P{sub n} = 0.1, indicating a small but nonzero amount of heat transfer from the day to nightside. The best physical model suggests a thermal inversion layer with an extra optical absorber of opacity kappa{sub e} = 0.05 cm{sup 2} g{sup -1}, placed near the 0.1 bar atmospheric pressure level. This inversion layer is located 10 times deeper in the atmosphere than the absorbers used in models to fit mid-infrared Spitzer detections of other irradiated hot Jupiters.

  11. Microsoft Word - Gage-KS.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Intercomparisons of Cloud Observations from the AL S-band Profiler and the ETL K-band Millimeter-Wave Cloud Radar on the R/V Ronald H. Brown during Nauru99 K. S. Gage and D. A. Carter National Oceanic and Atmospheric Administration Aeronomy Laboratory Boulder, Colorado P. E. Johnston and C. R. Williams Cooperative Institute for Research in Environmental Sciences University of Colorado Boulder, Colorado M. Ryan Science Technology Corporation Boulder, Colorado D. Hazen and B. W. Orr National

  12. Search for the decay B^+ \\to K_S^0 K_S^0 \\pi ^+

    SciTech Connect (OSTI)

    Aubert, B.; Bona, M.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Lopez, L.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Abrams, G.S.; Battaglia, M.; Brown, D.N.; Cahn, R.N.; Jacobsen, R.G.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /Bristol U. /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Karlsruhe U., EKP /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DSM, DAPNIA, Saclay /South Carolina U. /SLAC /Stanford U., Phys. Dept. /SUNY, Albany /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-02-23

    The authors search for charmless decays of charged B mesons to the three-body final state K{sub S}{sup 0}K{sub S}{sup 0}{pi}{sup +}. Using a data sample of 423.7 fb{sup -1} collected at the {Upsilon}(4S) resonance with the BABAR detector, corresponding to (465.1 {+-} 5.1) x 10{sup 6} B{bar B} pairs, they find no significant signal and determine a 90% confidence level upper limit on the branching fraction of 5.1 x 10{sup -7}.

  13. Analysis of natural gases, AL, AR, FL, GA, IL, IN, IA, KY, LA, MD, MI, MS, MO, NJ, NY, NC, OH, PA, TN, VA, and WV; 1951-1991 (for microcomputers). Data file

    SciTech Connect (OSTI)

    Not Available

    1991-01-01

    The U.S. Bureau of Mines diskette contains analysis and related source data for 2,357 natural gas samples collected from miscellaneous states, which include the following states: Alabama, Arkansas (except Arkoma Basin), Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maryland, Michigan, Mississippi, Missouri, New Jersey, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Virginia, and West Virginia. All samples were obtained and analyzed as part of the Bureau's investigations of occurrences of helium in natural gases of countries with free market economies. The survey has been conducted since 1917. The analysis contained on the diskette contain the full range of component analysis data. Five files are on the diskette: READ.ME, MISC.TXT, MISC.DBF, USHEANAL.DBF, and BASINCDE.TXT.

  14. Southwestern Power Administration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    032614 Correspondence between SWPA and 13 members of Congress: Paul Broun, R-GA, Rodney Davis R-IL, John Delaney, D-MD, Jeff Denham R-CA. Robert Dold R-IL, Bill Enyart D-IL, Bill...

  15. DOE - Office of Legacy Management -- R Krasberg and Sons Manufacturing Co -

    Office of Legacy Management (LM)

    IL 27 Krasberg and Sons Manufacturing Co - IL 27 FUSRAP Considered Sites Site: R. KRASBERG AND SONS MANUFACTURING CO. (IL.27) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Trade Finishing Services, Incorporated IL.27-1 Location: 2501 West Homer Street , Chicago , Illinois IL.27-2 Evaluation Year: 1990 IL.27-3 Site Operations: Provided personnel, facilities and equipment to produce machined parts for special equipment from materials furnished by

  16. padd map

    U.S. Energy Information Administration (EIA) Indexed Site

    FL PADD 4: Rocky Mountain PADD 5: West Coast PADD 2: Midwest PADD 1: East Coast PADD 3: Gulf Coast PADD1A: New England PADD1B: Central Atlantic PADD1C: Lower Atlantic Petroleum Administration for Defense Districts AK HI WA OR CA NV AZ MT WY CO UT ID ND SD NE KS OK MO MN WI MI IL IN OH KY TN IA NM TX AR LA AL MS WV VA NC SC GA FL ME NH VT NY PA NJ MD DE MA CT RI

  17. printer_friendly_org_chart

    Gasoline and Diesel Fuel Update (EIA)

    FL PADD 4: Rocky Mountain PADD 5: West Coast PADD 2: Midwest PADD 1: East Coast PADD 3: Gulf Coast PADD1A: New England PADD1B: Central Atlantic PADD1C: Lower Atlantic Petroleum Administration for Defense Districts AK HI WA OR CA NV AZ MT WY CO UT ID ND SD NE KS OK MO MN WI MI IL IN OH KY TN IA NM TX AR LA AL MS WV VA NC SC GA FL ME NH VT NY PA NJ MD DE MA CT RI

    Administrator U.S. Energy Information Administration Adam Sieminski Deputy Administrator Howard Gruenspecht Assistant Administrator

  18. paper-LSPP16

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FL PADD 4: Rocky Mountain PADD 5: West Coast PADD 2: Midwest PADD 1: East Coast PADD 3: Gulf Coast PADD1A: New England PADD1B: Central Atlantic PADD1C: Lower Atlantic Petroleum Administration for Defense Districts AK HI WA OR CA NV AZ MT WY CO UT ID ND SD NE KS OK MO MN WI MI IL IN OH KY TN IA NM TX AR LA AL MS WV VA NC SC GA FL ME NH VT NY PA NJ MD DE MA CT RI

    pantex On Womens Equality Day, we celebrate NNSA's talented Women in STEM NNSA's systems administrators keep the computers running

  19. Department of Energy (DOE) OpenNet documents

    Office of Scientific and Technical Information (OSTI)

    Account Request *First Name: *Last Name: *Organization: *Phone: *Email: Fax: *Address: *City: *State: Select AL AK AZ AR CA CO CT DE DC FL GA HI ID IL IN IA KS KY LA ME MD MA MI MN MS MO MT NE NV NH NJ NM NY NC ND OH OK OR PA RI SC SD TN TX UT VT VA WA WV WI WY Zip Code: *Affiliation: Select Federal Contractor *Access Level: Select View Release Official Releasing Official: release *Site Input Code: Select A2EDAP - Atmosphere to Electrons (A2e) Data Archive and Portal, Pacific Northwest National

  20. DOE Hydrogen and Fuel Cell Overview

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    DOE Hydrogen & Fuel Cell Overview Dr. Sunita Satyapal Program Manager U.S. Department of Energy Fuel Cell Technologies Program DOE/CESA/TTC Hydrogen and Fuel Cells Webinar December 14, 2010 2 Examples of DOE-funded Partners and Locations - Fuel Cell Technologies Program TX NM AZ NC AR CA CO HI WA IL KY MA MN MO MS AL NV TN UT WV ID FL MI ND OR OH IN MT WY IO NE KS OK AK LA GA WI SC VA PA DE MD DC NJ NY RI CT VT NH ME SD Source: US DOE 12/2010 2 3 Fuel Cells: Addressing Energy Challenges 4

  1. Print

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    < 5k 0 < 50k < 100k < 250k < 500k < 1M > 1M > 5M > 10M DE MD DC MA RI NJ AZ UT WY ID OR WA CA TX OK KS CO NE SD ND MN WI IL IA MO AR LA MS AL FL GA TN KY IN OH MI ME NH CT VT NY PA WV VA NC SC MT AK HI NV NM Princeton Plasma Physics Laboratory Procured Materials and Services 2015 (> $35M) Small business procurements in US: $14.73M

  2. Buildings Energy Data Book: 3.9 Educational Facilities

    Buildings Energy Data Book [EERE]

    6 2010 Regional New Construction and Renovations Expenditures for Public K-12 Schools ($Million) Region New Schools Additions Renovation Total Region 1 (CT, MA, ME, NH, RI, VT) Region 2 (NJ, NY, PA) Region 3 (DE, MD, VA, WV) Region 4 (KY, NC, SC, TN) Region 5 (AL, FL, GA, MS) Region 6 (IN, MI, OH) Region 7 (IL, MN, WI) Region 8 (IA, KS, MO, NE) Region 9 (AR, LA, OK, TX) Region 10 (CO, MT, ND, NM, SD, UT, WY) Region 11 (AZ, CA, HI, NV) Region 12 (AK, ID, OR, WA) Total Source(s): School Planning

  3. This list does not imply DOE endorsement of the individuals or companies identif

    Broader source: Energy.gov (indexed) [DOE]

    Pumping System Assessment Tool (PSAT) Qualified Specialists June 2016 Name E-mail Address Phone Number Location A Adidjaja, Jakub adijakub@gmail.com 951-776-2607 CA Ahlgren, Roy ‡ Royahlgren@comcast.net 847-751-0380 IL Alas, Victor vmalas@crimson.ua.edu 256-473-3486 AL Albright, David david.albright@simplot.com 559-301-8424 CA Altfeather, Nate altfeathern@saic.com 608-443-8458 WI Amundson, Todd tmamundson@bpa.gov 503-230-5491 OR Anderson, Kevin kanderson@us.grundfos.com 913-227-3400 KS Andrus,

  4. The soil microbiome influences grapevine-associated microbiota...

    Office of Scientific and Technical Information (OSTI)

    (ANL), Argonne, IL (United States); Univ. of Chicago, Chicago, IL (United States); Marine Biological Lab., Woods Hole, MA (United States); Zhejiang Univ., Hangzhou (China)...

  5. Using RSI format

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... University, Evanston, IL 60208. c Present address: Hebrew University, Jerusalem, Israel. d Present address: Northwestern University, Evanston, IL 60208. e Present ...

  6. NETL F 451.1/1-1, Categorical Exclusion Designation Form

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - Grantsburg, IL and Noble, IL FESCCStorage Division Bruce Brown A Nonconventional CO2-EOR Target in the Illinois Basin: Oil Reservoirs of the.. Project planning, data...

  7. DOE Zero Energy Ready Home Case Study: Weiss Building & Development...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Weiss Building & Development LLC, System Home, River Forest, IL DOE Zero Energy Ready Home Case Study: Weiss Building & Development LLC, System Home, River Forest, IL Case study of ...

  8. Predicting ecological roles in the rhizosphere using metabolome...

    Office of Scientific and Technical Information (OSTI)

    States). Biosciences Div.; Univ. of Chicago, Chicago, IL (United States). Dept. of Bioengineering. Argonne National Lab., Argonne, IL (United States). Biosciences Div. Univ. of...

  9. DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Evolutionary Home Builders, The Adaptation Home, Geneva, IL DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL DOE Zero Energy Ready ...

  10. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Argonne National Laboratory (ANL), Argonne, IL (United States) Argonne National Laboratory-Advanced Photon Source, Argonne, IL (United States) Atlanta Regional Office, ...

  11. EIS-0394: EPA Notice of Availability of the Draft Environmental...

    Broader source: Energy.gov (indexed) [DOE]

    Planning, Design, Construction and Operation a Coal Fueled Electric Power and Hydrogen Gas Production Plant, Four Alternative Sites: Mattoon, IL, Tuscola, IL, Jewett, TX and...

  12. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Laboratory (ANL), Argonne, IL (United States) Argonne National Laboratory-Advanced Photon Source, Argonne, IL (United States) Atlanta Regional Office, Atlanta, GA (United ...

  13. Cluster generator (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    Inventors: Donchev, Todor I. 1 ; Petrov, Ivan G. 2 + Show Author Affiliations (Urbana, IL) (Champaign, IL) Issue Date: 2011-05-31 OSTI Identifier: 1019407 Assignee: The Board ...

  14. Integrated Biorefineries:Biofuels, Biopower, and Bioproducts...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Solazyme, Inc. Peoria, IL Pilot Algae UOP, LLC Kapolei, HI Pilot Thermo - Pyrolysis ZeaChem, Inc. Boardman, OR Pilot Thermo - Pyrolysis Elevance* Boilingbrook, IL...

  15. The structural basis for receptor recognition of human interleukin-18

    SciTech Connect (OSTI)

    Tsutsumi, Naotaka; Kimura, Takeshi; Arita, Kyohei; Ariyoshi, Mariko; Ohnishi, Hidenori; Yamamoto, Takahiro; Zuo, Xiaobing; Maenaka, Katsumi; Park, Enoch Y.; Kondo, Naomi; Shirakawa, Masahiro; Tochio, Hidehito; Kato, Zenichiro

    2014-12-15

    Interleukin (IL)-18 is a proinflammatory cytokine that belongs to the IL-1 family and plays an important role in inflammation. The uncontrolled release of this cytokine is associated with severe chronic inflammatory disease. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines. Here, we present a crystal structure of human IL-18 bound to the two receptor extracellular domains. Generally, the receptors’ recognition mode for IL-18 is similar to IL-1β; however, certain notable differences were observed. The architecture of the IL-18 receptor second domain (D2) is unique among the other IL-1R family members, which presumably distinguishes them from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode. The structures and associated biochemical and cellular data should aid in developing novel drugs to neutralize IL-8 activity.

  16. The structural basis for receptor recognition of human interleukin-18

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Tsutsumi, Naotaka; Kimura, Takeshi; Arita, Kyohei; Ariyoshi, Mariko; Ohnishi, Hidenori; Yamamoto, Takahiro; Zuo, Xiaobing; Maenaka, Katsumi; Park, Enoch Y.; Kondo, Naomi; et al

    2014-12-15

    Interleukin (IL)-18 is a proinflammatory cytokine that belongs to the IL-1 family and plays an important role in inflammation. The uncontrolled release of this cytokine is associated with severe chronic inflammatory disease. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines. Here, we present a crystal structure of human IL-18 bound to the two receptor extracellular domains. Generally, the receptors’ recognition mode for IL-18 is similar to IL-1β; however, certain notable differences were observed. The architecture of the IL-18 receptor second domain (D2) is uniquemore » among the other IL-1R family members, which presumably distinguishes them from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode. The structures and associated biochemical and cellular data should aid in developing novel drugs to neutralize IL-8 activity.« less

  17. EA-1716: Final Environmental Assessment

    Office of Energy Efficiency and Renewable Energy (EERE)

    Honeywell International Inc Electric Drive Vehicle Battery and Component Manufacturing Initiative Project Massac County, IL

  18. --No Title--

    U.S. Energy Information Administration (EIA) Indexed Site

    | (Continued) | ct I | | | | | Year |(Conti-| | | | | | | Month | nued) | | | | | | | ||Average| IL | IN | MI | MN | OH |...

  19. Rotary Vapor Compression Cycle Technology: A Pathway to Ultra-Efficient Air Conditioning, Heating and Refrigeration

    Office of Energy Efficiency and Renewable Energy (EERE)

    Lead Performer: Sandia National Laboratories, Livermore, CAPartners: Creative Thermal Solutions, Urbana, IL

  20. Interaction of interleukin-5 with its receptors on murine leukemic BCL1 cells and its implication in biological activity

    SciTech Connect (OSTI)

    Tsuruoka, N.; Funakoshi, K.; Kodama, S.; Tsujimoto, M. (Suntory Institute for Biomedical Research, Mishima, Osaka (Japan))

    1990-02-01

    Interaction of interleukin (IL)-5 with its receptors on murine leukemic cell line, BCL1 cells was examined. {sup 125}I-labeled recombinant murine IL-5(rmIL-5) bound specifically to high-affinity receptors on BCL1 cells. rmIL-5, which was about 2500-fold more active than recombinant human IL-5(rhIL-5) in IgM-inducing activity on BCL1 cells, also showed about 5000-fold higher affinity to receptors. These results suggest that the bioactivity of IL-5 correlates with its receptor-binding activity. When disulfide bond formation was blocked, rmIL-5 dissociated into a monomer and lost its biological activity. This monomeric form of rmIL-5 also lost its ability to bind to cells, suggesting that dimer formation is essential for the biological activity of IL-5.

  1. DOE - Office of Legacy Management -- Billings Hospital - Small Animal

    Office of Legacy Management (LM)

    Facility - University of Chicago - IL 01 Billings Hospital - Small Animal Facility - University of Chicago - IL 01 FUSRAP Considered Sites Site: Billings Hospital, Small Animal Facility, University of Chicago (IL 01) Eliminated from consideration under FUSRAP due to limited scope of activities and 15 day half-life of P-32 Designated Name: Not Designated Alternate Name: Small Animal Facility, U. of Chicago IL.01-1 Location: University of Chicago , Chicago , Illinois IL.01-1 Evaluation Year:

  2. Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment

    SciTech Connect (OSTI)

    Kim, Jong-Hyuk; Frantz, Aric M.; Anderson, Katie L.; Graef, Ashley J.; Scott, Milcah C.; Robinson, Sally; Sharkey, Leslie C.; O'Brien, Timothy D.; Dickerson, Erin B.; Modiano, Jaime F.

    2014-04-15

    Interleukin-8 (IL-8) gene expression is highly up-regulated in canine hemangiosarcoma (HSA); however, its role in the pathogenesis of this disease is unknown. We investigated the expression of IL-8 in canine HSA tissues and cell lines, as well and the effects of IL-8 on canine HSA in vitro, and in vivo using a mouse xenograft model for the latter. Constitutive expression of IL-8 mRNA, IL-8 protein, and IL-8 receptor were variable among different tumor samples and cell lines, but they showed stable steady states in each cell line. Upon the addition of IL-8, HSA cells showed transient intracellular calcium fluxes, suggesting that their IL-8 receptors are functional and that IL-8 binding activates relevant signaling pathways. Yet, neither addition of exogenous IL-8 nor blockade of endogenous IL-8 by neutralizing anti-IL-8 antibody (α-IL-8 Ab) affected HSA cell proliferation or survival in vitro. To assess potential effects of IL-8 in other tumor constituents, we stratified HSA cell lines and whole tumor samples into “IL-8 high” and “IL-8 low” groups. Genome-wide gene expression profiling showed that samples in the “IL-8 high” tumor group were enriched for genes associated with a “reactive microenvironment,” including activation of coagulation, inflammation, and fibrosis networks. Based on these findings, we hypothesized that the effects of IL-8 on these tumors were mostly indirect, regulating interactions with the microenvironment. This hypothesis was supported by in vivo xenograft experiments where survival and engraftment of tumor cells was inhibited by administration of neutralizing α-IL-8 Ab. Together, our results suggest that IL-8 contributes to establishing a permissive microenvironment during the early stages of tumorigenesis in HSA. - Highlights: • IL-8 is expressed in canine hemangiosarcoma tumor samples and cell lines. • IL-8 transduces a relevant biological signal in canine hemangiosarcoma cells. • IL-8 gene signature is associated

  3. The microwave assisted synthesis of 1-alkyl-3-methylimidazolium bromide as potential corrosion inhibitor toward carbon steel in 1 M HCl solution saturated with carbon dioxide

    SciTech Connect (OSTI)

    Pasasa, Norman Vincent A. Bundjali, Bunbun; Wahyuningrum, Deana

    2015-09-30

    Injection of corrosion inhibitor into the fluid current of oil and gas pipelines is an effective way to mitigate corrosion rate on the inner-surface parts of pipelines, especially carbon steel pipelines. In this research, two alkylimidazolium ionic liquids, 1-decyl-3-methylimidazolium bromide (IL1) and 1-dodecyl-3-methylimidazolium bromide (IL2) have been synthesized and studied as a potential corrosion inhibitor towards carbon steel in 1 M HCl solution saturated with carbon dioxide. IL1 and IL2 were synthesized using microwave assisted organic synthesis (MAOS) method. Mass Spectrometry analysis of IL1 and IL2 showed molecular mass [M-H+] peak at 223.2166 and 251.2484, respectively. The FTIR,{sup 1}H-NMR and {sup 13}C-NMR spectra confirmed that IL1 and IL2 were successfully synthesized. Corrosion inhibition activity of IL1 and IL2 were determined using weight loss method. The results showed that IL1 and IL2 have the potential as good corrosion inhibitors with corrosion inhibition efficiency of IL1 and IL2 are 96.00% at 100 ppm (343 K) and 95.60% at 50 ppm (343 K), respectively. The increase in the concentration of IL1 and IL2 tends to improve their corrosion inhibition activities. Analysis of the data obtained from the weight loss method shows that the adsorption of IL1 and IL2 on carbon steel is classified into chemisorption which obeys Langmuir’s adsorption isotherm.

  4. Microsoft Word - figure_99.doc

    U.S. Energy Information Administration (EIA) Indexed Site

    7 U.S. Energy Information Administration | Natural Gas Annual Figure 6. Natural gas processing in the United States and the Gulf of Mexico, 2014 (million cubic feet) None 1-15,000 15,001-100,000 100,001-200,000 200,001-500,000 500,001 and over Sources: Energy Information Administration (EIA), Form EIA-64A, "Annual Report of the Origin of Natural Gas Liquids Production." IN OH TN WV VA KY MD PA NY VT NH MA CT ME RI DE DC NC SC GA FL NJ AL MS LA MO AR TX NM OK CO KS UT AZ WY NE IL IA MN

  5. Word Pro - Untitled1

    U.S. Energy Information Administration (EIA) Indexed Site

    State-Level Energy Consumption Estimates and Estimated Consumption per Capita, 2010 Consumption Consumption per Capita 14 U.S. Energy Information Administration / Annual Energy Review 2011 TX CA FL LA IL OH PA NY GA IN MI NC VA NJ TN WA KY AL MO MN WI SC OK CO IA MD AZ MA MS KS AR OR NE UT CT WV NM NV AK WY ID ND ME MT SD NH HI DE RI DC VT 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 0 2 4 6 8 10

  6. City of Geneva, Illinois (Utility Company) | Open Energy Information

    Open Energy Info (EERE)

    Geneva Place: Illinois Phone Number: 630-232-1503 Website: www.geneva.il.usindex.aspx?NI Twitter: @CityofGeneva Facebook: https:www.facebook.comgeneva.il Outage Hotline:...

  7. DOE - Office of Legacy Management -- Billings Hospital - Small...

    Office of Legacy Management (LM)

    of Chicago , Chicago , Illinois IL.01-1 Evaluation Year: 1979 IL.01-1 Site Operations: Nature of operations is not clear. Portions of Billings Hospital were reported to have been...

  8. Workplace Charging Challenge Partner: Schneider Electric

    Broader source: Energy.gov [DOE]

    Joined the Challenge: March 2013Headquarters: Palatine, ILCharging Locations: Cedar Rapids, IA; Palatine, IL; O'Fallon, MO; Des Plaines, IL; Knightdale, NC; West Kingston, RI; North Andover, MA;...

  9. Secretary Bodman Highlights Advanced Energy Initiative in Peoria...

    Office of Environmental Management (EM)

    Secretary Bodman Highlights Advanced Energy Initiative in Peoria, IL April 6, 2006 - 10:15am Addthis PEORIA, IL - Secretary of Energy Samuel W. Bodman today highlighted the goals ...

  10. RPT_PERIOD","R_S_NAME","LINE_NUM","PROD_CODE","PROD_NAME","PORT...

    U.S. Energy Information Administration (EIA) Indexed Site

    PROCESSOR-IL","IL","ILLINOIS",2 "applicationvnd.ms-excel","ATLANTIC TRADING MARKETING ",7,025,"Crude Oil",3401,"PEMBINA, ND","NORTH DAKOTA",2,260,"CANADA",58,3.14,14,"UNK...

  11. RPT_PERIOD","R_S_NAME","LINE_NUM","PROD_CODE","PROD_NAME","PORT...

    U.S. Energy Information Administration (EIA) Indexed Site

    PROCESSOR-IL","IL","ILLINOIS",2 "applicationvnd.ms-excel","ATLANTIC TRADING MARKETING ",4,025,"Crude Oil",3401,"PEMBINA, ND","NORTH DAKOTA",2,260,"CANADA",1,3.14,14,"UNKN...

  12. Natural Gas Weekly Update

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    In the Midwest, Horizon pipeline received approval to begin construction of a 70-mile pipeline from Joliet, IL north to McHenry, IL. When completed, the project will add...

  13. DOE Zero Energy Ready Home Case Study: BrightLeaf Homes, McCormick...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    BrightLeaf Homes, McCormick Avenue, Brookfield, IL DOE Zero Energy Ready Home Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL DOE Zero Energy Ready Home Case Study: ...

  14. Secretary Bodman in Illinois Highlights Scientific Research Investments to Advance America's Innovation

    Broader source: Energy.gov [DOE]

    ROMEOVILLE, IL - U.S. Secretary of Energy Samuel Bodman today joined Rep. Judy Biggert (IL-13th) at a technology firm in Illinois to highlight scientific research investments that have led to...

  15. Workbook Contents

    U.S. Energy Information Administration (EIA) Indexed Site

    File Name:","n3020il4m.xls" ,"Available from Web Page:","http:tonto.eia.govdnavnghistn3020il4m.htm" ,"Source:","Energy Information Administration" ,"For Help,...

  16. DOE - Office of Legacy Management -- Wyckoff Drawn Steel Co ...

    Office of Legacy Management (LM)

    Drawn Steel Co - IL 0-09 FUSRAP Considered Sites Site: Wyckoff Drawn Steel Co (IL 0-09) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: ...

  17. Workbook Contents

    U.S. Energy Information Administration (EIA) Indexed Site

    Date:","12312015" ,"Next Release Date:","01292016" ,"Excel File Name:","n3050il3m.xls" ,"Available from Web Page:","http:tonto.eia.govdnavnghistn3050il3m.htm"...

  18. "2014 Retail Power Marketers Sales- Residential"

    U.S. Energy Information Administration (EIA) Indexed Site

    ... Solutions Corp.","IL","Power Marketer",477853,4492034,227638.8,5.0676108 "Green Mountain Energy Company","IL","Power Marketer",24959,190336,16176.4,8.4988652 "Homefield ...

  19. "2014 Retail Power Marketers Sales- Total"

    U.S. Energy Information Administration (EIA) Indexed Site

    ... "Glacial Energy Holdings","IL","Power Marketer",2426,128194,8721.1,6.8030485 "Green Mountain Energy Company","IL","Power Marketer",24967,198273,16620.1,8.3824323 "Homefield ...

  20. "2014 Retail Power Marketers Sales- Commercial"

    U.S. Energy Information Administration (EIA) Indexed Site

    ... "Glacial Energy Holdings","IL","Power Marketer",2426,128194,8721.1,6.8030485 "Green Mountain Energy Company","IL","Power Marketer",8,7937,443.7,5.5902734 "Homefield ...

  1. Fermilab | Photowalk | 2015 Photowalk: Winning Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    here. Top Three Photos thumb First place photo by Mike Baker, Bolingbrook, IL Hi-res Med-res thumb Second place photo by Mike Baker, Bolingbrook, IL Hi-res Med-res thumb...

  2. Fermilab | Photowalk | 2012 Winning Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    information. Top Five Photos thumb First place photo by Stan Kirschner, Mundelein, IL Hi-res Med-res thumb Second place photo by Brian Schultz, Naperville, IL Hi-res Med-res...

  3. Gas Technology Institute (Partnership for Advanced Residential...

    Open Energy Info (EERE)

    Technology Institute (Partnership for Advanced Residential Retrofit) Jump to: navigation, search Name: Gas Technology Institute Place: Des Plaines, IL Website:...

  4. Utilization Technology Institute | Open Energy Information

    Open Energy Info (EERE)

    Utilization Technology Institute Jump to: navigation, search Name: Utilization Technology Institute Place: Des Plaines, IL References: Utilization Technology Institute1...

  5. Recent results from the Tevatron (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Research Org: Fermi National Accelerator Laboratory (FNAL), Batavia, IL Sponsoring Org: ... DETECTION; PARTICLE RAPIDITY; PHOSPHORS; QUANTUM CHROMODYNAMICS; STANDARD MODEL; ...

  6. Top quark properties from the Tevatron (Conference) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Research Org: Fermi National Accelerator Laboratory (FNAL), Batavia, IL Sponsoring Org: ... FERMILAB TEVATRON; LUMINOSITY; PHYSICS; QUANTUM CHROMODYNAMICS; SENSITIVITY; STANDARD ...

  7. Construction Safety Advisory Committee, Meeting Minutes- May 23, 2002

    Broader source: Energy.gov [DOE]

    Description of CSAC agenda activities during CSAC meeting in Chicago, IL. The meeting was held on May 23, 2002.

  8. DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Adaptation Home, Geneva, IL | Department of Energy Evolutionary Home Builders, The Adaptation Home, Geneva, IL DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL Case study of a DOE 2015 Housing Innovation Award winning custom home in the cold climate that got a HERS 30 without PV, with 2x8 24" on center walls with blown fiberglass and

  9. computational-fluid-dynamics-training

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Table of Contents Date Location Advanced Hydraulic and Aerodynamic Analysis Using CFD March 27-28, 2013 Argonne TRACC Argonne, IL Computational Hydraulics and Aerodynamics using STAR-CCM+ for CFD Analysis March 21-22, 2012 Argonne TRACC Argonne, IL Computational Hydraulics and Aerodynamics using STAR-CCM+ for CFD Analysis March 30-31, 2011 Argonne TRACC Argonne, IL Computational Hydraulics for Transportation Workshop September 23-24, 2009 Argonne TRACC West Chicago, IL

  10. Regulation of the human interleukin-2/interleukin-2 receptor system: A role for immunosuppression

    SciTech Connect (OSTI)

    Kaempfer, R.

    1994-12-31

    The strength of the cellular immune response is regulated to a large extent by the amount of interleukin-2 (IL-2) produced in response to a stimulus. The ability of lymphocytes and other cells to respond to IL-2 depends upon the expression of cell surface IL-2 receptors. Formation of a high-affinity IL-2 receptor is regulated primarily through induction of its {alpha} subunit, IL-2R{alpha}. Once formed, the IL-2R{alpha} chain turns over rapidly, rendering expression of high-affinity IL-2 receptors during the immune response dependent upon continuous activity of the IL-2R{alpha} gene. The induced expression of both human IL-2 and IL-2R{alpha} chains is sensitive to cell-mediated suppression by CD8 cells; depletion of CD8 cells leads to extensive superinduction. This coupled suppression of IL-2 and IL-2R{alpha} genes greatly increases the extend of control, and strongly limits the strength, of the signal transduced by this ligand/receptor system during an immune response. 29 refs., 3 figs.

  11. The depletion of Interleukin-8 causes cell cycle arrest and increases the efficacy of docetaxel in breast cancer cells

    SciTech Connect (OSTI)

    Shao, Nan; Chen, Liu-Hua; Ye, Run-Yi; Lin, Ying; Wang, Shen-Ming

    2013-02-15

    Highlights: ? IL-8 depletion affects cell cycle distribution. ? Intrinsic IL-8 mediates breast cancer cell migration and invasion. ? IL-8 siRNA down regulates key factors that control survival and metastatic pathway. ? IL-8 depletion reduces integrin ?3 expression. ? IL-8 depletion increases the chemosensitivity to docetaxel. -- Abstract: IL-8 is a multi-functional pro-inflammatory chemokine, which is highly expressed in cancers, such as ER-negative breast cancer. The present study demonstrates the pervasive role of IL-8 in the malignant progression of ER-negative breast cancer. IL-8 siRNA inhibited proliferation and delayed the G1 to S cell cycle progression in MDA-MB-231 and BT549 cells. IL-8 silencing resulted in the upregulation of the CDK inhibitor p27, the downregulation of cyclin D1, and the reduction of phosphorylated-Akt and NF-?B activities. IL-8 depletion also increased the chemosensitivity to docetaxel. These results indicate a role for IL-8 in promoting tumor cell survival and resistance to docetaxel and highlight the potential therapeutic significance of IL-8 depletion in ER-negative breast cancer patients.

  12. 2014 Retail Power Marketers Sales- Total

    U.S. Energy Information Administration (EIA) Indexed Site

    ... 6.03 Glacial Energy Holdings IL Power Marketer 2,426 128,194 8,721.1 6.80 Green Mountain Energy Company IL Power Marketer 24,967 198,273 16,620.1 8.38 Homefield Energy IL ...

  13. 2014 Retail Power Marketers Sales- Commercial

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    ... 6.03 Glacial Energy Holdings IL Power Marketer 2,426 128,194 8,721.1 6.80 Green Mountain Energy Company IL Power Marketer 8 7,937 443.7 5.59 Homefield Energy IL Power Marketer ...

  14. Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERKNF-?B signaling pathway

    SciTech Connect (OSTI)

    Che, Qi; Liu, Bin-Ya; Wang, Fang-Yuan; He, Yin-Yan; Lu, Wen; Liao, Yun; Gu, Wei; Wan, Xiao-Ping

    2014-03-28

    Highlights: IL-6 could promote endometrial cancer cells proliferation. IL-6 promotes its own production through an autocrine feedback loop. ERK and NF-?B pathway inhibitors inhibit IL-6 production and tumor growth. IL-6 secretion relies on the activation of ERKNF-?B pathway axis. An orthotopic nude endometrial carcinoma model confirms the effect of IL-6. - Abstract: Interleukin (IL)-6 as an inflammation factor, has been proved to promote cancer proliferation in several human cancers. However, its role in endometrial cancer has not been studied clearly. Previously, we demonstrated that IL-6 promoted endometrial cancer progression through local estrogen biosynthesis. In this study, we proved that IL-6 could directly stimulate endometrial cancer cells proliferation and an autocrine feedback loop increased its production even after the withdrawal of IL-6 from the medium. Next, we analyzed the mechanism underlying IL-6 production in the feedback loop and found that its production and IL-6-stimulated cell proliferation were effectively blocked by pharmacologic inhibitors of nuclear factor-kappa B (NF-?B) and extra-cellular signal-regulated kinase (ERK). Importantly, activation of ERK was upstream of the NF-?B pathways, revealing the hierarchy of this event. Finally, we used an orthotopic nude endometrial carcinoma model to confirm the effects of IL-6 on the tumor progression. Taken together, these data indicate that IL-6 promotes endometrial carcinoma growth through an expanded autocrine regulatory loop and implicate the ERKNF-?B pathway as a critical mediator of IL-6 production, implying IL-6 to be an important therapeutic target in endometrial carcinoma.

  15. Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro

    SciTech Connect (OSTI)

    Rubin, L.A.; Kurman, C.C.; Fritz, M.E.; Biddison, W.E.; Boutin, B.; Yarchoan, R.; Nelson, D.L.

    1985-11-01

    With the use of an enzyme-linked immunoabsorbent assay to measure soluble human interleukin 2 receptors (IL 2R), certain human T cell leukemia virus I (HTLV I)-positive T cell lines were found to spontaneously release large quantities of IL 2R into culture supernatants. This was not found with HTLV I-negative and IL 2 independent T cell lines, and only one of seven B cell-derived lines examined produced small amounts of IL 2R. In addition to this constitutive production of soluble IL 2R by certain cell lines, normal human peripheral blood mononuclear cells (PBMC) could be induced to release soluble IL 2R by plant lectins, the murine monoclonal antibody OKT3, tetanus toxoid, and allogeneic cells. Such activated cells also expressed cellular IL 2R measurable in detergent solubilized cell extracts. The generation of cellular and supernatant IL 2R was: dependent on cellular activation, rapid, radioresistant (3000 rad), and inhibited by cycloheximide treatment. NaDodSO4-polyacrylamide gel electrophoresis analysis of soluble IL 2R demonstrated molecules of apparent Mr = 35,000 to 40,000, and 45,000 to 50,000, respectively, somewhat smaller than the mature surface receptor on these cells. The release of soluble IL 2R appears to be a characteristic marker of T lymphocyte activation and might serve an immunoregulatory function during both normal and abnormal cell growth and differentiation.

  16. Human interleukin 2 receptor. beta. -chain gene: Chromosomal localization and identification of 5 prime regulatory sequences

    SciTech Connect (OSTI)

    Gnarra, J.R.; Otani, Hiroki; Wang, M.G.; McBride, O.W.; Sharon, M.; Leonard, W.J. )

    1990-05-01

    Interleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs). Such receptors represent a complex consisting of at least two proteins, the 55-kDa IL-2R{alpha} chain and the 70-kDa IL-2R{beta} chain. The low-affinity, IL-2R{alpha} chain cannot by itself transduce a mitogenic signal, whereas IL-2 stimulates resting lymphocytes through the intermediate-affinity, IL-2R{beta} receptor. The authors report here identification of the genomic locus for IL-2R{beta}. The exons are contained on four EcoRI fragments of 1.1, 9.2, 7.2, and 13.7 kilobases. The 1.1-kilobase EcoRI fragment lies at the 5{prime}-most end of the genomic locus and contains promoter sequences. The promoter contains no TATA box-like elements but does contain the d(GT){sub n} class of middle repetitive elements, which may play an interesting regulatory role. The IL-2R{beta} gene is localized to chromosome 22q11.2-q12, a region that is the locus for several lymphoid neoplasias.

  17. Ionic Liquid–Solute Interactions Studied by 2D NOE NMR Spectroscopy

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Khatun, Sufia; Castner, Edward W.

    2014-11-26

    Intermolecular interactions between a Ru²⁺(bpy)₃ solute and the anions and cations of four different ionic liquids (ILs) are investigated by 2D NMR nuclear Overhauser effect (NOE) techniques, including {¹H-¹⁹F} HOESY and {¹H-¹H} ROESY. Four ILs are studied, each having the same bis(trifluoromethylsulfonyl)amide anion in common. Two of the ILs have aliphatic 1-alkyl-1-methylpyrrolidinium cations, while the other two ILs have aromatic 1-alkyl-3-methylimidazolium cations. ILs with both shorter (butyl) and longer (octyl or decyl) cationic alkyl substituents are studied. NOE NMR results suggest that the local environment of IL anions and cations near the Ru²⁺(bpy)₃ solute is rather different from the bulkmore » IL structure. The solute-anion and solute-cation interactions are significantly different both for ILs with short vs long alkyl tails and for ILs with aliphatic vs aromatic cation polar head groups. In particular, the solute-anion interactions are observed to be about 3 times stronger for the cations with shorter alkyl tails relative to the ILs with longer alkyl tails. The Ru²⁺(bpy)₃ solute interacts with both the polar head and the nonpolar tail groups of the 1- butyl-1-methylpyrrolidinium cation but only with the nonpolar tail groups of the 1-decyl-1-methylpyrrolidinium cation.« less

  18. Ionic Liquid–Solute Interactions Studied by 2D NOE NMR Spectroscopy

    SciTech Connect (OSTI)

    Khatun, Sufia; Castner, Edward W.

    2014-11-26

    Intermolecular interactions between a Ru²⁺(bpy)₃ solute and the anions and cations of four different ionic liquids (ILs) are investigated by 2D NMR nuclear Overhauser effect (NOE) techniques, including {¹H-¹⁹F} HOESY and {¹H-¹H} ROESY. Four ILs are studied, each having the same bis(trifluoromethylsulfonyl)amide anion in common. Two of the ILs have aliphatic 1-alkyl-1-methylpyrrolidinium cations, while the other two ILs have aromatic 1-alkyl-3-methylimidazolium cations. ILs with both shorter (butyl) and longer (octyl or decyl) cationic alkyl substituents are studied. NOE NMR results suggest that the local environment of IL anions and cations near the Ru²⁺(bpy)₃ solute is rather different from the bulk IL structure. The solute-anion and solute-cation interactions are significantly different both for ILs with short vs long alkyl tails and for ILs with aliphatic vs aromatic cation polar head groups. In particular, the solute-anion interactions are observed to be about 3 times stronger for the cations with shorter alkyl tails relative to the ILs with longer alkyl tails. The Ru²⁺(bpy)₃ solute interacts with both the polar head and the nonpolar tail groups of the 1- butyl-1-methylpyrrolidinium cation but only with the nonpolar tail groups of the 1-decyl-1-methylpyrrolidinium cation.

  19. Demonstration Assessment of Light-Emitting Diode (LED) Parking Lot Lighting in Leavenworth, KS

    SciTech Connect (OSTI)

    Myer, Michael; Kinzey, Bruce R.; Curry, Ku'uipo

    2011-05-06

    This report describes the process and results of a demonstration of solid-state lighting (SSL) technology in a commercial parking lot lighting application, under the U.S. Department of Energy (DOE) Solid-State Lighting Technology GATEWAY Demonstration Program. The parking lot is for customers and employees of a Walmart Supercenter in Leavenworth, Kansas and this installation represents the first use of the LED Parking Lot Performance Specification developed by the DOE’s Commercial Building Energy Alliance. The application is a parking lot covering more than a half million square feet, lighted primarily by light-emitting diodes (LEDs). Metal halide wall packs were installed along the building facade. This site is new construction, so the installed baseline(s) were hypothetical designs. It was acknowledged early on that deviating from Walmart’s typical design would reduce the illuminance on the site. Walmart primarily uses 1000W pulse-start metal halide (PMH) lamps. In order to provide a comparison between both typical design and a design using conventional luminaires providing a lower illuminance, a 400W PMH design was also considered. As mentioned already, the illuminance would be reduced by shifting from the PMH system to the LED system. The Illuminating Engineering Society of North America (IES) provides recommended minimum illuminance values for parking lots. All designs exceeded the recommended illuminance values in IES RP-20, some by a wider margin than others. Energy savings from installing the LED system compared to the different PMH systems varied. Compared to the 1000W PMH system, the LED system would save 63 percent of the energy. However, this corresponds to a 68 percent reduction in illuminance as well. In comparison to the 400W PMH system, the LED system would save 44 percent of the energy and provide similar minimum illuminance values at the time of relamping. The LED system cost more than either of the PMH systems when comparing initial costs. However, when the life-cycle costs from energy and maintenance were factored into the scenario, the LED system had lower costs at the end of a 10-year analysis period. The LED system had a 6.1 year payback compared to the 1000W PMH system and a 7.5 year payback versus the 400W PMH system. The costs reflect high initial cost for the LED luminaire, plus more luminaires and (subsequently) more poles for the LED system. The other major issue affecting cost effectiveness was that Leavenworth, Kansas has very low electricity costs. The melded rate for this site was $0.056 per kWh for electricity. However, if the national electricity rate of $0.1022/kWh was used the payback would change to between four and five years for the LED system. This demonstration met the GATEWAY requirements of saving energy, matching or improving illumination, and being cost effective. The project also demonstrated that the Commercial Building Energy Alliance (CBEA) specification works in practice. Walmart appreciated having an entire site lighted by LEDs to gain more experience with the technology. Walmart is reviewing the results of the demonstration as they consider their entire real estate portfolio.

  20. Molecular mechanisms of ionic liquid cytotoxicity probed by an integrated experimental and computational approach

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yoo, Brian; Jing, Benxin; Jones, Stuart E.; Lamberti, Gary A.; Zhu, Yingxi; Shah, Jindal K.; Maginn, Edward J.

    2016-02-02

    Ionic liquids (ILs) are salts that remain liquid down to low temperatures, and sometimes well below room temperature. ILs have been called “green solvents” because of their extraordinarily low vapor pressure and excellent solvation power, but ecotoxicology studies have shown that some ILs exhibit greater toxicity than traditional solvents. A fundamental understanding of the molecular mechanisms responsible for IL toxicity remains elusive. Here we show that one mode of IL toxicity on unicellular organisms is driven by swelling of the cell membrane. Cytotoxicity assays, confocal laser scanning microscopy, and molecular simulations reveal that IL cations nucleate morphological defects in themore » microbial cell membrane at concentrations near the half maximal effective concentration (EC50) of several microorganisms. Lastly, cytotoxicity increases with increasing alkyl chain length of the cation due to the ability of the longer alkyl chain to more easily embed in, and ultimately disrupt, the cell membrane.« less

  1. Antigen-specific murine T cell clones produce soluble interleukin 2 receptor on stimulation with specific antigens

    SciTech Connect (OSTI)

    Wagner, D.K.; York-Jolley, J.; Malek, T.R.; Berzofsky, J.A.; Nelson, D.L.

    1986-07-15

    In this study, monoclonal antibodies were used to the murine IL 2 receptor (IL 2R) termed 3C7 and 7D4, which bind to different epitopes on the murine IL 2R, to develop an ELISA to measure soluble murine IL 2R. Surprisingly, stimulated murine spleen cells not only expressed cell-associated IL 2R, but also produced a considerable level of cellfree IL 2R in the culture supernatant fluid. To assess the fine specificity of this response, myoglobin-immune murine T cell clones were stimulated with appropriate or inappropriate antigen and syngeneic or allogeneic presenting cells. Proliferation, measured by (/sup 3/H) thymidine incorporation, and levels of soluble IL 2R were determined at day 4. The production of soluble IL2R displayed the same epitope fine specificity, genetic restriction, and antigen dose-response as the proliferative response. Indeed, in some cases there was sharper discrimination of epitope specificity and genetic restriction with the soluble IL 2R levels. There was also reproducible clone-to-clone variation in the amount of soluble receptor produced in response to antigen among 12 T cell clones and lines tested. In time course experiments, proliferation was greatest at day 3, whereas soluble IL 2R levels continued to rise in subsequent days. To the authors' knowledge, this is the first demonstration of release of secretion of soluble IL 2R by murine T cells, and the first demonstration of the fine specificity and genetic restriction of the induction of soluble IL 2R by specific antigen.

  2. Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Davenport, Gregory C.; Hittner, James B.; Otieno, Vincent; Karim, Zachary; Mukundan, Harshini; Fenimore, Paul W.; Hengartner, Nicolas W.; McMahon, Benjamin H.; Kempaiah, Prakasha; Ong’echa, John M.; et al

    2016-01-01

    Bmore » acteremia and malaria coinfection is a common and life-threatening condition in children residing in sub-Saharan Africa. We previously showed that coinfection with Gram negative (G[−]) entericacilli and Plasmodium falciparum ( Pf [+]) was associated with reduced high-density parasitemia (HDP, >10,000 parasites/ μ L), enhanced respiratory distress, and severe anemia. Since inflammatory mediators are largely unexplored in such coinfections, circulating cytokines were determined in four groups of children ( n = 206 , aged <3 yrs): healthy; Pf [+] alone; G[−] coinfected; and G[+] coinfected. Staphylococcus aureus and non-Typhi Salmonella were the most frequently isolated G[+] and G[−] organisms, respectively. Coinfected children, particularly those with G[−] pathogens, had lower parasite burden (peripheral and geometric mean parasitemia and HDP). In addition, both coinfected groups had increased IL-4, IL-5, IL-7, IL-12, IL-15, IL-17, IFN- γ , and IFN- α and decreased TNF- α relative to malaria alone. Children with G[−] coinfection had higher IL-1 β and IL-1Ra and lower IL-10 than the Pf [+] group and higher IFN- γ than the G[+] group. To determine how the immune response to malaria regulates parasitemia, cytokine production was investigated with a multiple mediation model. Cytokines with the greatest mediational impact on parasitemia were IL-4, IL-10, IL-12, and IFN- γ . Results here suggest that enhanced immune activation, especially in G[−] coinfected children, acts to reduce malaria parasite burden.« less

  3. Slide 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Illinois, Champaign, IL October 14-16, 2008 ARM AVP Workshop The Profiling Radiometer for Atmospheric and Cloud Observation PRACO Marian Klein, Vladimir Irisov, Vladimir Leuski University of Illinois, Champaign, IL October 14-16, 2008 ARM AVP Workshop BEST * Established in 2006 * Passive microwave remote sensing * Long experience with airborne, ship-borne, ground based microwave radiometers University of Illinois, Champaign, IL October 14-16, 2008 ARM AVP Workshop 60 GHz Boundary Layer

  4. travel-demand-modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Travel Demand Modeling for a Small sized MPO Using TRANSIMS Mohammad Sharif Ullah Champaign County Regional Planning Commission 1776 E Washington Street, Urbana, IL 61802 Phone: 217 328 3313 Ext 124 Email: This email address is being protected from spambots. You need JavaScript enabled to view it. List of Authors ================ Mohammad Sharif Ullah, Senior Transportation Engineer, CCRPC, Urbana, IL Asadur Rahman, PhD student, IIT, Chicago, IL Rita Morocoima-Black, Planning & Comm.

  5. DOE - Office of Legacy Management -- Palos Park Forest Preserve Site (A

    Office of Legacy Management (LM)

    Plot M) - IL 04 Palos Park Forest Preserve Site (A Plot M) - IL 04 FUSRAP Considered Sites Site: Palos Park Forest Preserve Site (A/Plot M) (IL.04 ) Designated Name: Alternate Name: Location: Evaluation Year: Site Operations: Site Disposition: Radioactive Materials Handled: Primary Radioactive Materials Handled: Radiological Survey(s): Site Status: Also see Site A/Plot M, Illinois, Decommissioned Reactor Site Documents Related to Palos Park Forest Preserve Site (A/Plot M) Surveillance of

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