Sample records for knotty head gc512

  1. Bottom head assembly

    DOE Patents [OSTI]

    Fife, A.B.

    1998-09-01T23:59:59.000Z

    A bottom head dome assembly is described which includes, in one embodiment, a bottom head dome and a liner configured to be positioned proximate the bottom head dome. The bottom head dome has a plurality of openings extending there through. The liner also has a plurality of openings extending there through, and each liner opening aligns with a respective bottom head dome opening. A seal is formed, such as by welding, between the liner and the bottom head dome to resist entry of water between the liner and the bottom head dome at the edge of the liner. In the one embodiment, a plurality of stub tubes are secured to the liner. Each stub tube has a bore extending there through, and each stub tube bore is coaxially aligned with a respective liner opening. A seat portion is formed by each liner opening for receiving a portion of the respective stub tube. The assembly also includes a plurality of support shims positioned between the bottom head dome and the liner for supporting the liner. In one embodiment, each support shim includes a support stub having a bore there through, and each support stub bore aligns with a respective bottom head dome opening. 2 figs.

  2. Maneuvering impact boring head

    DOE Patents [OSTI]

    Zollinger, W. Thor (Idaho Falls, ID); Reutzel, Edward W. (Idaho Falls, ID)

    1998-01-01T23:59:59.000Z

    An impact boring head may comprise a main body having an internal cavity with a front end and a rear end. A striker having a head end and a tail end is slidably mounted in the internal cavity of the main body so that the striker can be reciprocated between a forward position and an aft position in response to hydraulic pressure. A compressible gas contained in the internal cavity between the head end of the striker and the front end of the internal cavity returns the striker to the aft position upon removal of the hydraulic pressure.

  3. Maneuvering impact boring head

    DOE Patents [OSTI]

    Zollinger, W.T.; Reutzel, E.W.

    1998-08-18T23:59:59.000Z

    An impact boring head may comprise a main body having an internal cavity with a front end and a rear end. A striker having a head end and a tail end is slidably mounted in the internal cavity of the main body so that the striker can be reciprocated between a forward position and an aft position in response to hydraulic pressure. A compressible gas contained in the internal cavity between the head end of the striker and the front end of the internal cavity returns the striker to the aft position upon removal of the hydraulic pressure. 8 figs.

  4. from the Head

    E-Print Network [OSTI]

    Sally Goeke

    2009-07-14T23:59:59.000Z

    as well as the many weekly seminars and colloquia, continually ... from the Head ... Meyer Jerison) received the 2009 George David Birkhoff Prize. The prize is ..... Virginia Mashin Scholars ... Alan Legg, Mariana Smit Vega Garcia, Lloyd West.

  5. Reactor pressure vessel vented head

    DOE Patents [OSTI]

    Sawabe, James K. (San Jose, CA)

    1994-01-11T23:59:59.000Z

    A head for closing a nuclear reactor pressure vessel shell includes an arcuate dome having an integral head flange which includes a mating surface for sealingly mating with the shell upon assembly therewith. The head flange includes an internal passage extending therethrough with a first port being disposed on the head mating surface. A vent line includes a proximal end disposed in flow communication with the head internal passage, and a distal end disposed in flow communication with the inside of the dome for channeling a fluid therethrough. The vent line is fixedly joined to the dome and is carried therewith when the head is assembled to and disassembled from the shell.

  6. (K. Martin, Head) University Librarian

    E-Print Network [OSTI]

    He, Chuan

    (Elisabeth Long, Assoc Univ Lib) Law (S. Lewis) Sciences (B. Kern & A. TwissBrooks) Hum, SocSci & Spec Coll. Larsen, Head) Stacks Management (D. Bottorff, Head) Special Projects Reference Instruction Outreach (J

  7. HEAD OF CONTRACTING ACTIVITY

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM Flash2011-12 OPAMGeneralGuiding Documents and Links GuidingTank Farm6HEAD

  8. Reactor pressure vessel vented head

    DOE Patents [OSTI]

    Sawabe, J.K.

    1994-01-11T23:59:59.000Z

    A head for closing a nuclear reactor pressure vessel shell includes an arcuate dome having an integral head flange which includes a mating surface for sealingly mating with the shell upon assembly therewith. The head flange includes an internal passage extending therethrough with a first port being disposed on the head mating surface. A vent line includes a proximal end disposed in flow communication with the head internal passage, and a distal end disposed in flow communication with the inside of the dome for channeling a fluid therethrough. The vent line is fixedly joined to the dome and is carried therewith when the head is assembled to and disassembled from the shell. 6 figures.

  9. Role Profile Head of School

    E-Print Network [OSTI]

    Edinburgh, University of

    Role Profile Head of School Purpose of the Role The Head of School is accountable for:- · The provision of academic leadership, developing and delivering School objectives for, in particular, teaching, · The effective governance and management of the School and all of its resources. Context of the Role

  10. Bear Head LNG Corporation and Bear Head LNG (USA), LLC - FE Dkt...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Bear Head LNG Corporation and Bear Head LNG (USA), LLC - FE Dkt. No. - 15-33-LNG Bear Head LNG Corporation and Bear Head LNG (USA), LLC - FE Dkt. No. - 15-33-LNG The Office of...

  11. Heater head for stirling engine

    DOE Patents [OSTI]

    Corey, John A. (R.D. #2, Box 101 E, North Troy, NY 12182)

    1985-07-09T23:59:59.000Z

    A monolithic heater head assembly which augments cast fins with ceramic inserts which narrow the flow of combustion gas and obtains high thermal effectiveness with the assembly including an improved flange design which gives greater durability and reduced conduction loss.

  12. Heater head for Stirling engine

    SciTech Connect (OSTI)

    White, M.A.; Emigh, S.G.

    1987-06-09T23:59:59.000Z

    This patent describes a heater head for a Stirling engine comprising: a housing for enclosing the heater head with gas at a substantial elevated pressure; insulator means attached to the housing for insulating the heater head; inlet means attached to a regenerator in the housing for admission of relatively high pressure working fluid from the regenerator of a Stirling engine; a first annular heating wall in the housing attached to the inlet means for heating the working fluid; and, a second annular heating wall in the housing concentric with the first heating wall but of lesser diameters so that an annular space is formed between the first heating wall and the second heating wall for heating working fluid; and a third heating wall in the housing concentric with and smaller in diameter than the second heating wall forming the condensing area of a heat pipe between the second heating wall and the third heating wall.

  13. Pressure testing of torispherical heads

    SciTech Connect (OSTI)

    Rana, M.D. [Praxair, Inc., Tonawanda, NY (United States). Research and Development Dept.; Kalnins, A.; Updike, D.P. [Lehigh Univ., Bethlehem, PA (United States)

    1995-12-01T23:59:59.000Z

    Two vessels fabricated from SA516-70 steel with 6% knuckle radius torispherical heads were tested under internal pressure to failure. The D/t ratios of Vessel 1 and Vessel 2 were 238 and 185 respectively. The calculated maximum allowable working pressures of Vessel 1 and 2 heads using the ASME Section 8, Div. 1 rules and measured dimensions were 85 and 110 psi, respectively. Vessel 1 failed at a nozzle weld in the cylindrical shell at 700 psi pressure. Neither buckling nor any other objectionable deformation of the head was observed at a theoretical double-elastic-slope collapse pressure of 241 and a calculated buckling pressure of 270 psi. Buckles were observed developing slowly after 600 psi pressure, and a total of 22 buckles were observed after the test, having the maximum amplitude of 0.15 inch. Vessel 2 failed at the edge of the longitudinal weld of the cylindrical shell at 1,080 psi pressure. Neither buckling nor any other objectionable deformation of the head was observed up to the final pressure, which exceeded the theoretical double-elastic-slope collapse and calculated buckling pressures of 274 psi and 342 psi, respectively.

  14. Analyzing pulse from head motions in video

    E-Print Network [OSTI]

    Balakrishnan, Guha

    2014-01-01T23:59:59.000Z

    We extract heart rate and beat lengths from videos by measuring subtle head oscillations that accompany the cardiac cycle. Our method tracks features on the head, temporally filters their trajectories and performs principal ...

  15. Reactor Pressure Vessel Head Packaging & Disposal

    SciTech Connect (OSTI)

    Wheeler, D. M.; Posivak, E.; Freitag, A.; Geddes, B.

    2003-02-26T23:59:59.000Z

    Reactor Pressure Vessel (RPV) Head replacements have come to the forefront due to erosion/corrosion and wastage problems resulting from the susceptibility of the RPV Head alloy steel material to water/boric acid corrosion from reactor coolant leakage through the various RPV Head penetrations. A case in point is the recent Davis-Besse RPV Head project, where detailed inspections in early 2002 revealed significant wastage of head material adjacent to one of the Control Rod Drive Mechanism (CRDM) nozzles. In lieu of making ASME weld repairs to the damaged head, Davis-Besse made the decision to replace the RPV Head. The decision was made on the basis that the required weld repair would be too extensive and almost impractical. This paper presents the packaging, transport, and disposal considerations for the damaged Davis-Besse RPV Head. It addresses the requirements necessary to meet Davis Besse needs, as well as the regulatory criteria, for shipping and burial of the head. It focuses on the radiological characterization, shipping/disposal package design, site preparation and packaging, and the transportation and emergency response plans that were developed for the Davis-Besse RPV Head project.

  16. HeadLock : wide-range head pose estimation for low resolution video

    E-Print Network [OSTI]

    DeCamp, Philip (Philip James)

    2008-01-01T23:59:59.000Z

    This thesis focuses on data mining technologies to extract head pose information from low resolution video recordings. Head pose, as an approximation of gaze direction, is a key indicator of human behavior and interaction. ...

  17. Bear Head LNG Corporation and Bear Head LNG (USA), LLC FE Docket No. 15-14-NG

    Broader source: Energy.gov [DOE]

    On January 23, 2015, Bear Head LNG Corporation and Bear Head LNG (USA), LLC (together, Bear Head LNG), filed an application for long-term, multi-contract authorization to engage in imports from,...

  18. Bear Head LNG Corporation and Bear Head LNG (USA), LLC- FE Dkt No. 15-14-NG

    Broader source: Energy.gov [DOE]

    On January 23, 2015, Bear Head LNG Corporation and Bear Head LNG (USA), LLC (together, Bear Head LNG), filed an application for long-term, multi-contract authorization to engage in imports from,...

  19. Cylinder Head Gasket with Integrated Combustion Pressure Sensors...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cylinder Head Gasket with Integrated Combustion Pressure Sensors Cylinder Head Gasket with Integrated Combustion Pressure Sensors Poster presented at the 16th Directions in...

  20. acceleration head injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 2 Head injury...

  1. Laboratory Demonstration of a New American Low-Head Hydropower...

    Broader source: Energy.gov (indexed) [DOE]

    Laboratory Demonstration of a New American Low-Head Hydropower Turbine Laboratory Demonstration of a New American Low-Head Hydropower Turbine Laboratory Demonstration of a New...

  2. Nanotechnology in Head and Neck Cancer: The Race Is On

    E-Print Network [OSTI]

    El-Sayed, Ivan H.

    2010-01-01T23:59:59.000Z

    10.1007/s11912-010-0087-2 Nanotechnology in Head and Neckthe applications of nanotechnology in head and neck cancer,plasmonic gold nanotechnology. Keywords Nanotechnology .

  3. KU alumna to head Spencer Research Library

    E-Print Network [OSTI]

    2009-06-18T23:59:59.000Z

    12/5/13 KU alumna to head Spencer Research Library www.lib.ku.edu/news/spencer_head_announced.shtml 1/2 The University of Kansas Libraries Libraries Home Articles & Databases Catalog: books & more E-journals Research by Subject Course Reserves... Library Pages A-Z Images KU ScholarWorks KU Digital Collections Hours My Account Request Articles, Books, Friends & Benefactors Suggestions University of Kansas alumna Beth M. Whittaker will become the next head of KUs Kenneth Spencer Research Library...

  4. Epistemological resources 1 Running Head: EPISTEMOLOGICAL RESOURCES

    E-Print Network [OSTI]

    Elby, Andy

    Epistemological resources 1 Running Head: EPISTEMOLOGICAL RESOURCES Epistemological resources University Maryland, College Park Trisha Kagey Montgomery County Public Schools #12;Epistemological resources are better understood as made up of finer-grained cognitive resources whose activation depends sensitively

  5. SPATIAL TRANSFORMATIONS 1 Running head: Spatial transformations

    E-Print Network [OSTI]

    Zacks, Jeffrey M.

    SPATIAL TRANSFORMATIONS 1 Running head: Spatial transformations Multiple Systems for Spatial Imagery: Transformations of Objects and Bodies Jeffrey M. Zacks* and Barbara Tversky * Washington COGNITION & COMPUTATION #12;SPATIAL TRANSFORMATIONS 2 Abstract Problem-solving often requires imagining

  6. Vacuum compatible miniature CCD camera head

    DOE Patents [OSTI]

    Conder, Alan D. (Tracy, CA)

    2000-01-01T23:59:59.000Z

    A charge-coupled device (CCD) camera head which can replace film for digital imaging of visible light, ultraviolet radiation, and soft to penetrating x-rays, such as within a target chamber where laser produced plasmas are studied. The camera head is small, capable of operating both in and out of a vacuum environment, and is versatile. The CCD camera head uses PC boards with an internal heat sink connected to the chassis for heat dissipation, which allows for close(0.04" for example) stacking of the PC boards. Integration of this CCD camera head into existing instrumentation provides a substantial enhancement of diagnostic capabilities for studying high energy density plasmas, for a variety of military industrial, and medical imaging applications.

  7. Head & base production optimization : setup time reduction

    E-Print Network [OSTI]

    Guo, Haiqing

    2009-01-01T23:59:59.000Z

    At Schlumberger, the make-to-order strategy and number of Head & Base product types (about 1000 types) requires a flexible manufacturing system in which the machine setup is frequent. However, the lengthy CNC machine setup ...

  8. Facilitating Forgiveness 1 Running head: FACILITATING FORGIVENESS

    E-Print Network [OSTI]

    Ahmad, Sajjad

    Facilitating Forgiveness 1 Running head: FACILITATING FORGIVENESS FACILITATING FORGIVENESS. Infidelity causes significant damage for couples and results in a loss of trust and relationship stability undermine a relationship's stability and security, resulting in confusion, loss of trust, and tremendous

  9. Electro-optic voltage sensor head

    DOE Patents [OSTI]

    Crawford, Thomas M. (Idaho Falls, ID); Davidson, James R. (Idaho Falls, ID); Woods, Gregory K. (Cornelius, OR)

    1999-01-01T23:59:59.000Z

    The invention is an electro-optic voltage sensor head designed for integration with existing types of high voltage transmission and distribution apparatus. The sensor head contains a transducer, which comprises a transducing material in which the Pockels electro-optic effect is observed. In the practice of the invention at least one beam of electromagnetic radiation is routed into the transducing material of the transducer in the sensor head. The beam undergoes an electro-optic effect in the sensor head when the transducing material is subjected to an E-field. The electro-optic effect is observed as a differential phase a shift, also called differential phase modulation, of the beam components in orthogonal planes of the electromagnetic radiation. In the preferred embodiment the beam is routed through the transducer along an initial axis and then reflected by a retro-reflector back substantially parallel to the initial axis, making a double pass through the transducer for increased measurement sensitivity. The preferred embodiment of the sensor head also includes a polarization state rotator and at least one beam splitter for orienting the beam along major and minor axes and for splitting the beam components into two signals which are independent converse amplitude-modulated signals carrying E-field magnitude and hence voltage information from the sensor head by way of optic fibers.

  10. Electro-optic voltage sensor head

    DOE Patents [OSTI]

    Crawford, T.M.; Davidson, J.R.; Woods, G.K.

    1999-08-17T23:59:59.000Z

    The invention is an electro-optic voltage sensor head designed for integration with existing types of high voltage transmission and distribution apparatus. The sensor head contains a transducer, which comprises a transducing material in which the Pockels electro-optic effect is observed. In the practice of the invention at least one beam of electromagnetic radiation is routed into the transducing material of the transducer in the sensor head. The beam undergoes an electro-optic effect in the sensor head when the transducing material is subjected to an E-field. The electro-optic effect is observed as a differential phase a shift, also called differential phase modulation, of the beam components in orthogonal planes of the electromagnetic radiation. In the preferred embodiment the beam is routed through the transducer along an initial axis and then reflected by a retro-reflector back substantially parallel to the initial axis, making a double pass through the transducer for increased measurement sensitivity. The preferred embodiment of the sensor head also includes a polarization state rotator and at least one beam splitter for orienting the beam along major and minor axes and for splitting the beam components into two signals which are independent converse amplitude-modulated signals carrying E-field magnitude and hence voltage information from the sensor head by way of optic fibers. 6 figs.

  11. Rope and the art of knot-tying in the seafaring of the ancient Eastern Mediterranean

    E-Print Network [OSTI]

    Charlton, William Harrison

    1996-01-01T23:59:59.000Z

    , s. v. k. svz6k. ivov) and "flaxen, " respectively. Yet A. D. Godley, the translator of the Loch Classical Library edition of Herodotus printed in 1920, attached the following note to his translation: "Xevz6Aivov is apparently not really flax...

  12. Training and Certification of Lock Operators IMTS Heads-up Paper Heads-up Paper

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Training and Certification of Lock Operators IMTS Heads-up Paper 1 Heads-up Paper Training called "Training and Certification of Lock and Dam Operators." Interested individuals can send ideas of the Training and Certification program. Examples of what will be in those draft documents are as follows

  13. Most Workers Who Suffer Head Injuries- Were Not Wearing Head Protection

    Broader source: Energy.gov [DOE]

    A survey by the U.S. Department of Labors Bureau of Labor Statistics (BLS) of accidents and injuries noted that most workers who suffered impact injuries to the head were not wearing head protection. In addition, the same survey showed that the majority of workers were injured while performing their normal jobs at their regular worksites.

  14. Compact organic vapor jet printing print head

    DOE Patents [OSTI]

    Forrest, Stephen R; McGraw, Gregory

    2013-12-24T23:59:59.000Z

    A first device is provided. The first device includes a print head, and a first gas source hermetically sealed to the print head. The print header further includes a first layer comprising a plurality of apertures, each aperture having a smallest dimension of 0.5 to 500 microns. A second layer is bonded to the first layer. The second layer includes a first via in fluid communication with the first gas source and at least one of the apertures. The second layer is made of an insulating material.

  15. Use of Gold in Head and Neck

    E-Print Network [OSTI]

    Walter, Peter

    Use of Gold in Head and Neck Cancer Treatments Q & A with Dr. Frank McCormick UCSF Helen Diller Family Comprehensive Cancer Center Cancer Center Connection Frank McCormick, PhD, FRS, is the director of the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC) and is Associate Dean of the UCSF School

  16. Probability Primer 1 Running head: PROBABILITY PRIMER

    E-Print Network [OSTI]

    Yuille, Alan L.

    provides the opportunity to draw upon work in computer science, engineering, mathematics, and statisticsProbability Primer 1 Running head: PROBABILITY PRIMER A Primer on Probabilistic Inference Thomas L. Griffiths Department of Psychology University of California, Berkeley Alan Yuille Department of Statistics

  17. VICE CHANCELLOR Signature of Head of School

    E-Print Network [OSTI]

    Tobar, Michael

    VICE CHANCELLOR Signature of Head of School Date (dd/mm/yy) Following is a report on the professional and consultative work of my School/section over the twelve months of (year) School/Section One. Yes No (Nil Return) Total number of staff within School/Section at year end who are eligible to engage

  18. Department Heads Meeting March15, 2012

    E-Print Network [OSTI]

    Wechsler, Risa H.

    Department Heads Meeting March15, 2012 David B. MacFarlane #12;Science program news Update on LBNE » Significant advance in our understanding of the neutrino sector » Centerpiece of the national program » SLAC Neutrinos Science interest beyond neutrino properties » Colleagues from KIPAC Energy release from core

  19. Adherence to Head Computed Tomography Guidelines in the Setting of Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    Jones, Landon A; Morley, Eric J; Grant, William D; Wojcik, Susan M; Paolo, William F

    2014-01-01T23:59:59.000Z

    Adherence to Head Computed Tomography Guidelines for Mildal Adherence to Head Computed Tomography Guidelines system,non-contrast head computed tomography (CT) in patients with

  20. Gas cushion control of OVJP print head position

    DOE Patents [OSTI]

    Forrest, Stephen R

    2014-10-07T23:59:59.000Z

    An OVJP apparatus and method for applying organic vapor or other flowable material to a substrate using a printing head mechanism in which the print head spacing from the substrate is controllable using a cushion of air or other gas applied between the print head and substrate. The print head is mounted for translational movement towards and away from the substrate and is biased toward the substrate by springs or other means. A gas cushion feed assembly supplies a gas under pressure between the print head and substrate which opposes the biasing of the print head toward the substrate so as to form a space between the print head and substrate. By controlling the pressure of gas supplied, the print head separation from the substrate can be precisely controlled.

  1. Type B Accident Investigation Board Report on the Head Injury...

    Office of Environmental Management (EM)

    on the Head Injury to a Miner at the Waste Isolation Pilot Plant, Carlsbad, New Mexico - August 25, 2004 Type B Accident Investigation Board Report on the Head Injury to a Miner at...

  2. World's Largest Solar Energy Project Heads to Mojave | Department...

    Broader source: Energy.gov (indexed) [DOE]

    World's Largest Solar Energy Project Heads to Mojave World's Largest Solar Energy Project Heads to Mojave April 16, 2010 - 4:47pm Addthis A California company will harness the...

  3. 1 INTRODUCTION High-head storage hydropower plants operate

    E-Print Network [OSTI]

    Floreano, Dario

    1 INTRODUCTION High-head storage hydropower plants operate their turbines during periods of high Polytechnique Fdrale de Lausanne, 1015 Lausanne, Switzerland ABSTRACT: High-head storage hydropower plants

  4. MODEL BUILDING FOR INTERACTIVE SEGMENTATION OF THE FEMORAL HEAD

    E-Print Network [OSTI]

    McKenzie, Rick

    MODEL BUILDING FOR INTERACTIVE SEGMENTATION OF THE FEMORAL HEAD G ZSEMLYE 1 , G SZKELY 1 1 by the user. Our first #12;study concentrates on the femoral head, containing only two well defined point the femoral neck at its smallest perimeter with a circle and the femoral head with a half-sphere. After

  5. Contact Stress in Hips with Osteonecrosis of the Femoral Head

    E-Print Network [OSTI]

    Iglic, Ales

    Contact Stress in Hips with Osteonecrosis of the Femoral Head Matej Daniel, PhD*; Srecko Herman, MD by elevated con- tact stress. Osteonecrosis of the femoral head is a relatively common disorder of the human of the hip are af- fected by osteonecrosis of the femoral head,8 they have been the subject of numerous

  6. Automatic Tissue Classification for the Human Head from Multispectral MRI

    E-Print Network [OSTI]

    Utah, University of

    1 Automatic Tissue Classification for the Human Head from Multispectral MRI Tolga Tasdizen, David for classifying multispectral MR scans of the human head into nine tissue classes. User initialization is adopted. #12;Chapter 1 Introduction Classification of head magnetic resonance imaging (MRI) data

  7. Oculomotor Responses to Active Head Movements in Darkness

    E-Print Network [OSTI]

    Ramat, Stefano

    information on head rotation from the vestibular system to the saccade-generating mechanism in the brain stem482 Oculomotor Responses to Active Head Movements in Darkness Formulation and Testing Sistemistica, Universit di Pavia, Pavia, Italy Passive head rotation in darkness produces vestibular nystagmus

  8. Computational Modeling of Brain Dynamics during Repetitive Head Motions

    E-Print Network [OSTI]

    Burtscher, Martin

    Computational Modeling of Brain Dynamics during Repetitive Head Motions Igor Szczyrba School the HIC scale to arbitrary head motions. Our simulations of the brain dynamics in sagittal and horizontal injury modeling, resonance effects 1 Introduction A rapid head motion can result in a severe brain injury

  9. Head erosion with emittance growth in PWFA

    SciTech Connect (OSTI)

    Li, S. Z.; Adli, E.; England, R. J.; Frederico, J.; Gessner, S. J.; Hogan, M. J.; Litos, M. D.; Walz, D. R.; Muggli, P.; An, W.; Clayton, C. E.; Joshi, C.; Lu, W.; Marsh, K. A.; Mori, W.; Vafaei, N. [SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States) and SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States) and University of Oslo, Oslo, N-0316 (Norway) and SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States); Max Planck Institute for Physics, Munich (Germany); University of California, Los Angeles, CA 90095 (United States)

    2012-12-21T23:59:59.000Z

    Head erosion is one of the limiting factors in plasma wakefield acceleration (PWFA). We present a study of head erosion with emittance growth in field-ionized plasma from the PWFA experiments performed at the FACET user facility at SLAC. At FACET, a 20.3 GeV bunch with 1.8 Multiplication-Sign 10{sup 10} electrons is optimized in beam transverse size and combined with a high density lithium plasma for beam-driven plasma wakefield acceleration experiments. A target foil is inserted upstream of the plasma source to increase the bunch emittance through multiple scattering. Its effect on beamplasma interaction is observed with an energy spectrometer after a vertical bend magnet. Results from the first experiments show that increasing the emittance has suppressed vapor field-ionization and plasma wakefields excitation. Plans for the future are presented.

  10. Integrated head package for top mounted nuclear instrumentation

    DOE Patents [OSTI]

    Malandra, Louis J. (McKeesport, PA); Hornak, Leonard P. (Forest Hills, PA); Meuschke, Robert E. (Monroeville, PA)

    1993-01-01T23:59:59.000Z

    A nuclear reactor such as a pressurized water reactor has an integrated head package providing structural support and increasing shielding leading toward the vessel head. A reactor vessel head engages the reactor vessel, and a control rod guide mechanism over the vessel head raises and lowers control rods in certain of the thimble tubes, traversing penetrations in the reactor vessel head, and being coupled to the control rods. An instrumentation tube structure includes instrumentation tubes with sensors movable into certain thimble tubes disposed in the fuel assemblies. Couplings for the sensors also traverse penetrations in the reactor vessel head. A shroud is attached over the reactor vessel head and encloses the control rod guide mechanism and at least a portion of the instrumentation tubes when retracted. The shroud forms a structural element of sufficient strength to support the vessel head, the control rod guide mechanism and the instrumentation tube structure, and includes radiation shielding material for limiting passage of radiation from retracted instrumentation tubes. The shroud is thicker at the bottom adjacent the vessel head, where the more irradiated lower ends of retracted sensors reside. The vessel head, shroud and contents thus can be removed from the reactor as a unit and rested safely and securely on a support.

  11. Estimating IMU heading error from SAR images.

    SciTech Connect (OSTI)

    Doerry, Armin Walter

    2009-03-01T23:59:59.000Z

    Angular orientation errors of the real antenna for Synthetic Aperture Radar (SAR) will manifest as undesired illumination gradients in SAR images. These gradients can be measured, and the pointing error can be calculated. This can be done for single images, but done more robustly using multi-image methods. Several methods are provided in this report. The pointing error can then be fed back to the navigation Kalman filter to correct for problematic heading (yaw) error drift. This can mitigate the need for uncomfortable and undesired IMU alignment maneuvers such as S-turns.

  12. Council on Environmental Quality - Memorandum for Heads of Federal...

    Open Energy Info (EERE)

    navigation, search OpenEI Reference LibraryAdd to library Memorandum: Council on Environmental Quality - Memorandum for Heads of Federal Departments and Agencies Abstract This...

  13. antigenic polar heads: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stenger; Robert L. Modlin; Ian A. Wilson; Steven A. Porcelli; Michael B. Brenner 1999-01-01 11 Head: Vacancy Quality & Standards Mathematics Websites Summary: : Dr Sarah...

  14. adaptive head motion: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and performs principal ... Balakrishnan, Guha 2014-01-01 7 Computational Modeling of Brain Dynamics during Repetitive Head Motions Computer Technologies and Information...

  15. Closure head for a nuclear reactor

    DOE Patents [OSTI]

    Wade, Elman E. (South Huntingdon, PA)

    1980-01-01T23:59:59.000Z

    A closure head for a nuclear reactor includes a stationary outer ring integral with the reactor vessel with a first rotatable plug disposed within the stationary outer ring and supported from the stationary outer ring by a bearing assembly. A sealing system is associated with the bearing assembly to seal the annulus defined between the first rotatable plug and the stationary outer ring. The sealing system comprises tubular seal elements disposed in the annulus with load springs contacting the tubular seal elements so as to force the tubular seal elements against the annulus in a manner to seal the annulus. The sealing system also comprises a sealing fluid which is pumped through the annulus and over the tubular seal elements causing the load springs to compress thereby reducing the friction between the tubular seal elements and the rotatable components while maintaining a gas-tight seal therebetween.

  16. Light water reactor lower head failure analysis

    SciTech Connect (OSTI)

    Rempe, J.L.; Chavez, S.A.; Thinnes, G.L. [EG and G Idaho, Inc., Idaho Falls, ID (United States)] [and others

    1993-10-01T23:59:59.000Z

    This document presents the results from a US Nuclear Regulatory Commission-sponsored research program to investigate the mode and timing of vessel lower head failure. Major objectives of the analysis were to identify plausible failure mechanisms and to develop a method for determining which failure mode would occur first in different light water reactor designs and accident conditions. Failure mechanisms, such as tube ejection, tube rupture, global vessel failure, and localized vessel creep rupture, were studied. Newly developed models and existing models were applied to predict which failure mechanism would occur first in various severe accident scenarios. So that a broader range of conditions could be considered simultaneously, calculations relied heavily on models with closed-form or simplified numerical solution techniques. Finite element techniques-were employed for analytical model verification and examining more detailed phenomena. High-temperature creep and tensile data were obtained for predicting vessel and penetration structural response.

  17. Head Observation Organizer (HObO)

    SciTech Connect (OSTI)

    Steven Predmore

    2008-03-06T23:59:59.000Z

    The Head Observation Organizer, HObO, is a computer program that stores and manages measured ground-water levels. HObO was developed to help ground-water modelers compile, manage, and document water-level data needed to calibrate ground-water models. Well-construction and water-level data from the U.S. Geological Survey National Water Database (NWIS) easily can be imported into HObO from the NWIS web site (NWISWeb). The water-level data can be flagged to determine which data will be included in the calibration data set. The utility program HObO_NWISWeb was developed to simplify the down loading of well and water-level data from NWISWeb. An ArcGIS NWISWeb Extension was developed to retrieve site information from NWISWeb. A tutorial is presented showing the basic elements of HObO.

  18. Topic Models to Interpret MeSH MEDLINE's Medical Subject Headings

    E-Print Network [OSTI]

    Newman, David

    ://ii.nlm.nih.gov/mti.shtml #12;MeSH heading Major MeSH heading Major qualifier MeSH-qualifier combination Humans Brain metabolism Brain (metabolism) Table 1. Most frequent MeSH headings, major MeSH headings, major qualifiers and MeTopic Models to Interpret MeSH MEDLINE's Medical Subject Headings David Newman12 , Sarvnaz Karimi

  19. Mobile Museum Tours 1 RUNNING HEAD: MOBILE MUSEUM TOURS

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Mobile Museum Tours 1 RUNNING HEAD: MOBILE MUSEUM TOURS Using mobile technologies for multimedia MUSEUM TOURS Abstract Mobile technology was used to deliver learner-centred experiences to visitors: Across generations and cultures, Banff : Canada (2006)" #12;Mobile Museum Tours 2 RUNNING HEAD: MOBILE

  20. Poverty and Productivity in Female-Headed Households in Zimbabwe

    E-Print Network [OSTI]

    Horrell, Sara; Krishnan, Pramila

    A household survey conducted in rural Zimbabwe in 2001 is used to compare the position of de facto and de jure female-headed households to those with a male head. These households are characterised by different forms of poverty that impinge...

  1. Quantitative determination of vortex core dimensions in head-to-head domain walls using off-axis electron holography

    E-Print Network [OSTI]

    Dunin-Borkowski, Rafal E.

    transformations.7 Recent experimental reports confirm these predictions of domain wall movement8Quantitative determination of vortex core dimensions in head-to-head domain walls using off-dimensional characterization of vortex core spin structures, which is important for future magnetic data storage based

  2. Kinetic and Friction Head Loss Impacts on Horizontal Water Supply and Aquifer Storage and Recovery Wells

    E-Print Network [OSTI]

    Blumenthal, Benjamin

    2014-12-02T23:59:59.000Z

    well construction or intra-wellbore head loss. Currently no analytical groundwater model rigorously accounts for intra-wellbore kinetic and friction head loss. We have developed a semi-analytical, intra-wellbore head loss model dynamically linked...

  3. High energy activation data library (HEAD-2009)

    SciTech Connect (OSTI)

    Mashnik, Stepan G [Los Alamos National Laboratory; Korovin, Yury A [NON LANL; Natalenko, Anatoly A [NON LANL; Konobeyev, Alexander Yu [NON LANL; Stankovskiy, A Yu [NON LANL

    2010-01-01T23:59:59.000Z

    A proton activation data library for 682 nuclides from 1 H to 210Po in the energy range from 150 MeV up to 1 GeV was developed. To calculate proton activation data, the MCNPX 2.6.0 and CASCADE/INPE codes were chosen. Different intranuclear cascade, preequilibrium, and equilibrium nuclear reaction models and their combinations were used. The optimum calculation models have been chosen on the basis of statistical correlations for calculated and experimental proton data taken from the EXFOR library of experimental nuclear data. All the data are written in ENDF-6 format. The library is called HEPAD-2008 (High-Energy Proton Activation Data). A revision of IEAF-2005 neutron activation data library has been performed. A set of nuclides for which the cross-section data can be (and were) updated using more modern and improved models is specified, and the corresponding calculations have been made in the present work. The new version of the library is called IEAF-2009. The HEPAD-2008 and IEAF-2009 are merged to the final HEAD-2009 library.

  4. Sorghum head silage, with and without haylage, for fattening steers

    E-Print Network [OSTI]

    Stilwell, Daniel Emerson

    1963-01-01T23:59:59.000Z

    steers in all treatment groups during the first few days of the trial. A ma)ority of the cases occurred in the group fed soxghum heads and 2 lb. CSM and most of these cases wex'e during the first three days of the experiment when s dry ground mixture..., and 2 lb. CSM (285 lb. ). The steers fed heads, haylage, and 1 lb. CSM had the lowest total gain (254 lb. ), but this was not significantly diffexent from the group fed heads, haylage, and 2 lb. of CSM (264 lb. ), ox the group fed grain, haylage...

  5. arsenic affects head: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 430 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  6. acute head injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 336 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  7. active head lice: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 251 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  8. acute head trauma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 278 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  9. affects head kidney: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 344 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  10. advanced inoperable head: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 208 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  11. acute severe head: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 252 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  12. adult human head: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 350 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  13. Printed circuit board for a CCD camera head

    DOE Patents [OSTI]

    Conder, Alan D. (Tracy, CA)

    2002-01-01T23:59:59.000Z

    A charge-coupled device (CCD) camera head which can replace film for digital imaging of visible light, ultraviolet radiation, and soft to penetrating x-rays, such as within a target chamber where laser produced plasmas are studied. The camera head is small, capable of operating both in and out of a vacuum environment, and is versatile. The CCD camera head uses PC boards with an internal heat sink connected to the chassis for heat dissipation, which allows for close (0.04" for example) stacking of the PC boards. Integration of this CCD camera head into existing instrumentation provides a substantial enhancement of diagnostic capabilities for studying high energy density plasmas, for a variety of military industrial, and medical imaging applications.

  14. Zeroth-order inversion of transient head observations

    SciTech Connect (OSTI)

    Vasco, D.W.

    2007-08-15T23:59:59.000Z

    A high-frequency, asymptotic solution for transient head,appropriate for a medium containing smoothly varying heterogeneity,provides a basis for efficient inverse modeling. The semi analyticsolution is trajectory based, akin to ray methods used in modeling wavepropagation, and may be constructed by post processing the output of anumerical simulator. For high frequencies, the amplitude sensitivities,the relationship between changes in flow properties and changes in headampliude, are dominated by the phase term which may be computed directlyfrom the output of the simulator. Thus, transient head waveforms may beinverted with little more computation than is required to invert arrivaltimes. An applicatino to synthetic head values indicates that thetechnique can be used to improve the fit to waveforms. An application totransient head data from the Migration experiment in Switzerland revealsa narrow, high conductivity pathway within a 0.5 m thick zone offracturing.

  15. Theoretical collapse pressures for two pressurized torispherical heads

    SciTech Connect (OSTI)

    Kalnins, A.; Updike, D.P. [Lehigh Univ., Bethlehem, PA (United States); Rana, M.D. [Praxair, Inc., Tonawanda, NY (United States). Research and Development Dept.

    1995-12-01T23:59:59.000Z

    In order to determine the pressures at which real torispherical heads fail upon a single application of pressure, two heads were pressurized in recent Praxair tests, and displacements and strains were recorded at various locations. In this paper, theoretical results for the two test heads are presented in the form of curves of pressure versus crown deflections, using the available geometry and material parameters. From these curves, limit and collapse pressures are calculated, using procedures permitted by the ASME B and PV Code Section 8/Div.2. These pressures are shown to vary widely, depending on the method and model used to calculate them. The effect of no stress relief on the behavior of the Praxair test heads is also evaluated and found to be of no significance for neither the objectives of the tests nor the objectives of this paper. The results of this paper are submitted as an enhancement to the experimental results recorded during the Praxair tests.

  16. Metastasis of genitourinary tumors to the head and neck region

    E-Print Network [OSTI]

    Ogunyemi, Ore; Rojas, A.; Hematpour, K.; Rogers, D.; Head, C.; Bennett, C.

    2010-01-01T23:59:59.000Z

    D. Rogers C. Head C. Bennett Received: 14 SeptemberO. Ogunyemi A. Rojas C. Bennett David GeVen School ofLos Angeles, CA, USA C. Bennett Department of Urology,

  17. Bear Head LNG Corporation and Bear Head LNG (USA), LLC- FE Dkt. No.- 15-33-LNG

    Broader source: Energy.gov [DOE]

    The Office of Fossil Energy gives notice of receipt of an application filed on February 25, 2015, by Bear Head LNG, requesting long-term multi-contract authority as further described in their...

  18. Chapter 17 Eye-head Gaze shifts Oxford Handbook on Eye Movements

    E-Print Network [OSTI]

    Corneil, Brian D.

    1 Chapter 17 Eye-head Gaze shifts Oxford Handbook on Eye Movements "The Neural Basis of Gaze Shifts" 1. Kinematics of eye-head gaze shifts a. Terminology for describing eye-head gaze shifts b. Variability in eye and head motion during gaze shifts c. Gaze shifts in complex environments d. Bottom

  19. SAYA's head-eye coordination system Correspondence of image-width and angle

    E-Print Network [OSTI]

    Beimel, Amos

    SAYA's head-eye coordination system Correspondence of image-width and angle 335 - 359 [deg] 0 - 25 - 25 [deg] is input, head and eyes move to right side. b) If the angle within 335 - 359 [deg] is input, head and eyes move to left side. SAYA's head-eye coordination system Correspondence of image

  20. The Mechatonic Design of a Human-like Robot Head Karsten Berns1

    E-Print Network [OSTI]

    Berns, Karsten

    The Mechatonic Design of a Human-like Robot Head Karsten Berns1 Carsten Hillenbrand1 and Krzystof. In this paper the design concept as well as the constructed human-like robot head is introduced. Main goal of the head design is the support of an adequate human machine interaction. Therefore, our robots head should

  1. Integrated head package cable carrier for a nuclear power plant

    DOE Patents [OSTI]

    Meuschke, Robert E. (Monroeville, PA); Trombola, Daniel M. (Murrysville, PA)

    1995-01-01T23:59:59.000Z

    A cabling arrangement is provided for a nuclear reactor located within a containment. Structure inside the containment is characterized by a wall having a near side surrounding the reactor vessel defining a cavity, an operating deck outside the cavity, a sub-space below the deck and on a far side of the wall spaced from the near side, and an operating area above the deck. The arrangement includes a movable frame supporting a plurality of cables extending through the frame, each connectable at a first end to a head package on the reactor vessel and each having a second end located in the sub-space. The frame is movable, with the cables, between a first position during normal operation of the reactor when the cables are connected to the head package, located outside the sub-space proximate the head package, and a second position during refueling when the cables are disconnected from the head package, located in the sub-space. In a preferred embodiment, the frame straddles the top of the wall in a substantially horizontal orientation in the first position, pivots about an end distal from the head package to a substantially vertically oriented intermediate position, and is guided, while remaining about vertically oriented, along a track in the sub-space to the second position.

  2. Remote controlled ISI devices for RPV bottom head

    SciTech Connect (OSTI)

    Shiga, S. [Toshiba Corp., Yokohama (Japan); Mori, H. [Tokyo Electric Power Co. (Japan); Kobayashi, K. Sasaki, T. [Ishikawajima-Harima Heavy Industries Co., Ltd., Yokohama (Japan)

    1995-08-01T23:59:59.000Z

    The bottom head of a reactor pressure vessel (RPV) of the boiling water reactor (BWR) is one of the areas on which it is very difficult to perform an inservice inspection (ISI). Welds in a bottom head central disk and a drain nozzle are required to be inspected, but its accessibility is restricted by a RPV skirt, a thermal insulation, control rod drive housings and incore monitor housings. Therefore, the remote mechanized scanners are necessary to access and examine the welds. Two kinds of new device were developed to accomplish this inspection. The bottom head central disk weld inspection device has a parallel link mechanism scanning arm with a combined-transducer module to get as much as wide scanning area between control rod drive housings. The device is driven along the weld by moving on the separable track which is set temporally on the bottom head insulation. The drain nozzle weld inspection device has a horseshoe shaped gear mechanism to drive a combined-transducer module. The device is set up on to the drain nozzle using an insertion handle. Both devices have an emergency retrieval mechanism to withdraw the devices in case of power loss accident. Those devices were demonstrated by a mock-up test to be applicable to the inspection of the RPV bottom head.

  3. Experimental study of head loss and filtration for LOCA debris

    SciTech Connect (OSTI)

    Rao, D.V.; Souto, F.J. [Science and Engineering Associates, Inc., Albuquerque, NM (United States)

    1996-02-01T23:59:59.000Z

    A series of controlled experiments were conducted to obtain head loss and filtration characteristics of debris beds formed of NUKON{trademark} fibrous fragments, and obtain data to validate the semi-theoretical head loss model developed in NUREG/CR-6224. A thermally insulated closed-loop test set-up was used to conduct experiments using beds formed of fibers only and fibers intermixed with particulate debris. A total of three particulate mixes were used to simulate the particulate debris. The head loss data were obtained for theoretical fiber bed thicknesses of 0.125 inches to 4.0 inches; approach velocities of 0.15 to 1.5 ft/s; temperatures of 75 F and 125 F; and sludge-to-fiber nominal concentration ratios of 0 to 60. Concentration measurements obtained during the first flushing cycle were used to estimate the filtration efficiencies of the debris beds. For test conditions where the beds are fairly uniform, the head loss data were predictable within an acceptable accuracy range by the semi-theoretical model. The model was equally applicable for both pure fiber beds and the mixed beds. Typically the model over-predicted the head losses for very thin beds and for thin beds at high sludge-to-fiber mass ratios. This is attributable to the non-uniformity of such debris beds. In this range the correlation can be interpreted to provide upper bound estimates of head loss. This is pertinent for loss of coolant accidents in boiling water reactors.

  4. An improved dosimetric model of the head and brain

    E-Print Network [OSTI]

    Bouchet, Lionel Gerard

    1995-01-01T23:59:59.000Z

    Br). Other radionuclides considered may deposit in bone withm the head region (cranium or the spinal skeleton) (is'I, 2P, ssP, tssRe, 'ssRe, 'ssSm, "7~Sb, ssSr, s Sr, "nY, ss~Tc, tsiCs, ss"Ra), or m the thyroid fss~ Tc, and all iodme radionuclides... tagged to them (i. e. , radiopharmaceuticals). Nevertheless, studies of the small-scale dosimetry of the bram, and more generally, the organs of the head (brain, eyes thyroid, skull, skin), have not kept pace with the current advances in nuclear...

  5. Running Head: TESTOSTERONE AND POWER Testosterone and power

    E-Print Network [OSTI]

    Schultheiss, Oliver C.

    Running Head: TESTOSTERONE AND POWER Testosterone and power Steven J. Stanton and Oliver C. Schultheiss University of Michigan, Ann Arbor, MI, USA To appear in: K. Dowding (Ed.), Encyclopedia of power-647-9440, email: stantons@umich.edu #12;Testosterone and power 2 Across many studies in humans, two functional

  6. Associate Professor, Head, Research Institute of Circuits and Systems

    E-Print Network [OSTI]

    Wang, Yu

    ), and power and reliability aware system design methodology. Dr. Wang has authored and coauthored over 100.1-2017.12 Research on LTE-Advanced Soft-Baseband Processing System o National Key Technology Program, o PI: Yu WangRESUME Yu Wang Associate Professor, Head, Research Institute of Circuits and Systems Department

  7. New Director Heads Actuarial Science Program - Department of ...

    E-Print Network [OSTI]

    Sally

    2002-01-03T23:59:59.000Z

    Department of Mathematics x Purdue University x West Lafayette, Indiana. Summer 2001 ... information as well as the current (new) plan of study. ... Allen Weitsman, Associate Head. Lawrence Brown .... Professor J. J. Price was the featured speaker in Purdue's Focus on Teaching ..... Virginia Mashin Scholarship ($2,500).

  8. HIGH RESOLUTION, MRI-BASED, SEGMENTED, COMPUTERIZED HEAD PHANTOM.

    E-Print Network [OSTI]

    Duncan, James S.

    was created from 124 transverse MRI images of a healthy normal. The transverse T2 slices, recorded in a 256x. Internal volumes compare favorably to those described in the ICRP Reference Man. Conclusion and improved. We have developed a voxel based head phantom by manually drawing contours on 124 transverse MRI

  9. IMAGINED TRANSFORMATIONS 1 Running head: IMAGINED TRANSFORMATION OF BODIES

    E-Print Network [OSTI]

    Zacks, Jeffrey M.

    IMAGINED TRANSFORMATIONS 1 Running head: IMAGINED TRANSFORMATION OF BODIES Imagined Transformations TRANSFORMATIONS 2 Abstract A number of spatial reasoning problems can be solved by performing an imagined transformation of one's egocentric perspective. A series of experiments were carried out to characterize

  10. ADSORPTION OF CHAIN MOLECULES WITH A POLAR HEAD

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    983 ADSORPTION OF CHAIN MOLECULES WITH A POLAR HEAD A SCALING DESCRIPTION S. ALEXANDER (*) Physique (Reu le 24 mars 1977, accepte le 4 mai 1977) Rsum. 2014 L'adsorption de molcules en chanes une The adsorption of chain molecules at an interface is investigated assuming that the molecule has both a polar

  11. Simultaneous multi-headed imager geometry calibration method

    DOE Patents [OSTI]

    Tran, Vi-Hoa (Newport News, VA); Meikle, Steven Richard (Penshurst, AU); Smith, Mark Frederick (Yorktown, VA)

    2008-02-19T23:59:59.000Z

    A method for calibrating multi-headed high sensitivity and high spatial resolution dynamic imaging systems, especially those useful in the acquisition of tomographic images of small animals. The method of the present invention comprises: simultaneously calibrating two or more detectors to the same coordinate system; and functionally correcting for unwanted detector movement due to gantry flexing.

  12. Molecular architecture of the prolate head of bacteriophage T4

    E-Print Network [OSTI]

    Rossmann, Michael G.

    -Maklaya Street, Moscow 117997, Russia; and Department of Biology, Center for Advanced Training in Cell) The head of bacteriophage T4 is a prolate icosahedron with one unique portal vertex to which the phage tail by the portal protein gp20. The prohead contains an internal core made up of the major core protein, gp22

  13. Diffuse optical imaging of the whole head Maria Angela Franceschini

    E-Print Network [OSTI]

    Diffuse optical imaging of the whole head Maria Angela Franceschini Danny K. Joseph Theodore J@nmr.mgh.harvard.edu Abstract. Near-Infrared Spectroscopy NIRS and diffuse optical im- aging DOI are increasingly used to detect of optodes in NIRS instruments has hampered measurement of optical signals from diverse brain regions. Our

  14. Beam Head Erosion in Self-Ionized Plasma Wakefield Accelerators

    SciTech Connect (OSTI)

    Berry, M.K.; Blumenfeld, I.; Decker, F.J.; Hogan, M.J.; Ischebeck, R.; Iverson, R.H.; Kirby, N.A.; Siemann, Robert H.; Walz, D.R.; /SLAC; Clayton, C.E.; Huang, C.; Joshi, C.; Lu, W.; Marsh, K.A.; Mori, W.B.; Zhou, M.; /UCLA; Katsouleas, T.C.; Muggli, P.; Oz, E.; /Southern California U.

    2008-01-28T23:59:59.000Z

    In the recent plasma wakefield accelerator experiments at SLAC, the energy of the particles in the tail of the 42 GeV electron beam were doubled in less than one meter [1]. Simulations suggest that the acceleration length was limited by a new phenomenon--beam head erosion in self-ionized plasmas. In vacuum, a particle beam expands transversely in a distance given by {beta}*. In the blowout regime of a plasma wakefield [2], the majority of the beam is focused by the ion channel, while the beam head slowly spreads since it takes a finite time for the ion channel to form. It is observed that in self-ionized plasmas, the head spreading is exacerbated compared to that in pre-ionized plasmas, causing the ionization front to move backward (erode). A simple theoretical model is used to estimate the upper limit of the erosion rate for a bi-gaussian beam by assuming free expansion of the beam head before the ionization front. Comparison with simulations suggests that half this maximum value can serve as an estimate for the erosion rate. Critical parameters to the erosion rate are discussed.

  15. Learning expressive human-like head motion sequences from speech

    E-Print Network [OSTI]

    Busso, Carlos

    With the development of new trends in human-machine interfaces, animated feature films and video games, better avatars and virtual agents are required that more accurately mimic how humans communicate and interact. Gestures the emotional perception of facial animations [6]. Given the importance of head motion in human-human

  16. EARLY HEAD START Effects of Fathers, Neighborhoods and Family Structure

    E-Print Network [OSTI]

    randomly assigned - 1,513 to Early Head Start - 1,488 to other child care program #12;Highlights of the EHS disorder and aggression ­ Depression ­ Alcoholism and other drug abuse · Parental history of relationship Expulsion Lost Job Arrested Substance Abuse % No % Yes #12;Father Antisocial Behavior · 86.1% Low Risk (

  17. Head Knowledge: Summary (Segment from the Tin Shed essay)

    E-Print Network [OSTI]

    O'Laughlin, Jay

    Head Knowledge: Summary (Segment from the Tin Shed essay) While certainly much more nuanced than would declare that it's to be discovered outside Tin Shed, viewed from the wooden bench. Reality of reliability and validity (Frey 1994:95-104). While traveling outside the Tin Shed, systematic analysis

  18. Budzik et al., page 1 of 30 RUNNING HEAD

    E-Print Network [OSTI]

    Bustamante, Fabin E.

    Budzik et al., page 1 of 30 RUNNING HEAD Resource Discovery Assistants JOURNAL TITLE International Resource Discovery in the Context of Ongoing Tasks with Proactive Assistants CONTACT AUTHOR Jay Budzik. Evanston, IL 60201 USA +1 847 467-1771 (phone) +1 847 491-5258 (fax) budzik@infolab.nwu.edu AUTHORS Jay

  19. PPA Department Heads Initial Impressions and SLAC Challenges

    E-Print Network [OSTI]

    Wechsler, Risa H.

    1 PPA Department Heads Initial Impressions and SLAC Challenges James Tarpinian ES&H Director January 19, 2012 #12;2 Agenda · Initial impressions · 2011 Performance · ES&H focus areas and initiatives for 2012 ES&H Director Chief Safety Officer #12;3 Initial impressions Evolutionary change

  20. Head-Tail Modes for Strong Space Charge

    SciTech Connect (OSTI)

    Burov, Alexey

    2008-12-01T23:59:59.000Z

    Head-tail modes are described here for the space charge tune shift significantly exceeding the synchrotron tune. General equation for the modes is derived. Spatial shapes of the modes, their frequencies, and coherent growth rates are explored. The Landau damping rates are also found. Suppression of the transverse mode coupling instability by the space charge is explained.

  1. F A C U L T Y DIVISION HEAD

    E-Print Network [OSTI]

    Gering, Jon C.

    of employment at Truman. Richard J. Coughlin Director of Libraries; Head, Division of Libraries and Museums Carolina. (2001) Janet Romine Reference Librarian BA, Bowling Green State University; MLS, Indiana University. (1999) Libraries and Museums G E N E R A L C A T A L O G 175 2003-2005 #12;Judith Sapko Special

  2. F A C U L T Y DIVISION HEAD

    E-Print Network [OSTI]

    Gering, Jon C.

    of Libraries; Head, Division of Libraries and Museums BA, Merrimack College; MS (LS), Simmons College. (1995, Indiana University. (1980) Gayla McHenry Supervisor, Library Circulation Department BS, Northeast Missouri, University of North Carolina. (2001) Janet Romine Reference Librarian BA, Bowling Green State University; MLS

  3. Ms. Maushumi, Head Mistress Babul Sarkar, Vice President

    E-Print Network [OSTI]

    Nahar, Sultana Nurun

    Ms. Maushumi, Head Mistress Babul Sarkar, Vice President Char Domdoama Primary School Vill: Char Razzaq-Shamsun Best Teacher Award and Abdul Awal Sarkar Best Student Awards in Char Domdoma Primary School Dear Ms. Maushumi and Mr. Sarkar, My proposal for the introduction of one teaching and three

  4. THE RECONSTRUCTION OF GROUNDWATER PARAMETERS FROM HEAD DATA IN AN

    E-Print Network [OSTI]

    Knowles, Ian W.

    ancillary data is fundamental to the process of modelling a groundwater system. In an unconfined aquifer of the unconfined groundwater parameters as the unique minimum of a convex functional. 1. Introduction It is commonTHE RECONSTRUCTION OF GROUNDWATER PARAMETERS FROM HEAD DATA IN AN UNCONFINED AQUIFER IAN KNOWLES

  5. Managing Fusarium Head Blight in Virginia Small Grains

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    Breeder, Dept. of Crop and Soil Environmental Sciences, Virginia Tech. cgriffey@vt.edu C.J. LIN Vice@vt.edu WADE THOMASON Extension Grains Specialist, Dept. of Crop and Soil Environmental Sciences, Virginia TechManaging Fusarium Head Blight in Virginia Small Grains MELISSA KELLER Graduate Student, Dept

  6. Recto Running Head 1 Available Potential Energy and Exergy in

    E-Print Network [OSTI]

    Tailleux, Remi

    ) remains the main framework for studying the atmospheric and oceanic energy cycles. Because the APE energy cycle . . . . . . . . . . . . . . . . . . . . 23 Classical view of the ocean energy cycleRecto Running Head 1 Available Potential Energy and Exergy in Stratified Fluids R´emi Tailleux

  7. Effects of Head Movement on Perceptions of Humanoid Robot Behavior

    E-Print Network [OSTI]

    Plotkin, Joshua B.

    Effects of Head Movement on Perceptions of Humanoid Robot Behavior Emily Wang Constantine Lignos@cs.yale.edu ABSTRACT This paper examines human perceptions of humanoid robot behavior, specifically how perception and write about the experience. A coding scheme originally created to gauge human intentionality was applied

  8. Neural compass or epiphenomenon? Experimental and theoretical investigations into the rodent head direction cell system

    E-Print Network [OSTI]

    van der Meer, Matthijs

    2007-11-28T23:59:59.000Z

    How does the brain convert sensory information into abstract representations that can support complex behaviours? The rodent head-direction (HD) system, whose cell ensembles represent head direction in the horizontal plane, ...

  9. University at Albany Students Head Back to a School Powered with...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    University at Albany Students Head Back to a School Powered with Renewable Energy University at Albany Students Head Back to a School Powered with Renewable Energy August 24, 2012...

  10. Real World Demonstration of a New American Low-Head Hydropower...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Real World Demonstration of a New American Low-Head Hydropower Unit Real World Demonstration of a New American Low-Head Hydropower Unit Real World Demonstration of a New American...

  11. Geostatistical inference of hydraulic conductivity and dispersivities from hydraulic heads and tracer data

    E-Print Network [OSTI]

    Cirpka, Olaf Arie

    Geostatistical inference of hydraulic conductivity and dispersivities from hydraulic heads; accepted 25 April 2006; published 10 August 2006. [1] In groundwater, hydraulic heads and solute arrival times depend primarily on the hydraulic conductivity field and hydraulic boundary conditions. The spread

  12. A representation of changing heading direction in human cortical areas pVIP and CSv

    E-Print Network [OSTI]

    Royal Holloway, University of London

    Running title: Changing heading direction in the human brain Keywords: egomotion; f1 A representation of changing heading direction in human cortical in the environment, we continually change direction. Much work has examined how the brain

  13. Dr. Martin Wolf, Ph. D Head of Biomedical Optics Research Laboratory

    E-Print Network [OSTI]

    Zanibbi, Richard

    and oxygenation of the brain and muscle. Since 2002 he heads the Biomedical Optics Research LaboratoryDr. Martin Wolf, Ph. D Head of Biomedical Optics Research Laboratory Clinic of Neonatology

  14. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 51, NO. 12, DECEMBER 2004 2129 Influence of Head Tissue Conductivity in Forward

    E-Print Network [OSTI]

    Utah, University of

    IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 51, NO. 12, DECEMBER 2004 2129 Influence of Head Tissue Conductivity in Forward and Inverse Magnetoencephalographic Simulations Using Realistic Head Abstract--The influence of head tissue conductivity on mag- netoencephalography (MEG) was investigated

  15. Model 923-B Mouse Gas Anesthesia Head Holder Adaptor Adjustment Features

    E-Print Network [OSTI]

    Kleinfeld, David

    Model 923-B Mouse Gas Anesthesia Head Holder Adaptor Adjustment Features Dorsal/Ventral dial.352.3139 Toll Free: 1.877.352.3275 ^^ci&ion Q)e&i^n^^^r ^esea/H^/i Model 923-B Mouse Gas Anesthesia Head Holder 923B-1/07 #12;MODEL 923-B MOUSE GAS ANESTHESIA HEAD HOLDER The KOPF Mouse Gas Anesthesia Head Holder

  16. USE OF GCLS TO CONTROL LEAKAGE THROUGH GEOMEMBRANE DEFECTS UNDER HIGH HYDRAULIC HEADS

    E-Print Network [OSTI]

    Zornberg, Jorge G.

    USE OF GCLS TO CONTROL LEAKAGE THROUGH GEOMEMBRANE DEFECTS UNDER HIGH HYDRAULIC HEADS Christine T liners under conditions representative of dams (i.e., high hydraulic heads). Specifically, the objective of interface contact, hydraulic head, and GCL hydration procedures on the leakage rate were considered

  17. Volume Currents in Forward and Inverse MEG Simulations Using Realistic Head Models

    E-Print Network [OSTI]

    Utah, University of

    Volume Currents in Forward and Inverse MEG Simulations Using Realistic Head Models Robert Van of magnetoencephalographic (MEG) forward or inverse sim- ulations in realistic head models. We verify the accuracy, in an inhomogeneous, non-spherical realistic head model, the magnetic field normal to the MEG detector due to volume

  18. Modeling Attractor Deformation in the Rodent Head-Direction JEREMY P. GOODRIDGE1

    E-Print Network [OSTI]

    Touretzky, David S.

    Modeling Attractor Deformation in the Rodent Head-Direction System JEREMY P. GOODRIDGE1 AND DAVID S attractor deformation in the rodent head-direction system. J Neurophysiol 83: 34023410, 2000. We present a model of the head-direction circuit in the rat that improves on earlier models in several respects

  19. Volume Currents in Forward and Inverse Magnetoencephalographic Simulations Using Realistic Head Models

    E-Print Network [OSTI]

    Utah, University of

    Volume Currents in Forward and Inverse Magnetoencephalographic Simulations Using Realistic Head of magnetoencephalographic MEG forward or in- verse simulations in realistic head models. We verify the accu- racy of our, in an inhomoge- neous, nonspherical realistic head model, the magnetic field normal to the MEG detector due

  20. NEURAL MODELS OF HEAD-DIRECTION CELLS PETER ZEIDMAN JOHN A. BULLINARIA

    E-Print Network [OSTI]

    Bullinaria, John

    We have seen that navigation requires knowledge of heading, and that HD cells in the brain actNEURAL MODELS OF HEAD-DIRECTION CELLS PETER ZEIDMAN JOHN A. BULLINARIA School of Computer Science background of Head Direction Cells, and existing models of them, we introduce an improved neural model

  1. Double-ring network model of the head-direction system Xiaohui Xie,1,

    E-Print Network [OSTI]

    Xie, Xiaohui Sunney

    Double-ring network model of the head-direction system Xiaohui Xie,1, * Richard H. R. Hahnloser,1,2 and H. Sebastian Seung1,2 1 Department of Brain and Cognitive Sciences, Massachusetts Institute 2002; published 9 October 2002 In the head-direction system, the orientation of an animal's head

  2. Volume Currents in Forward and Inverse MEG Simulations Using Realistic Head Models

    E-Print Network [OSTI]

    Utah, University of

    Volume Currents in Forward and Inverse MEG Simulations Using Realistic Head Models Robert Van of magnetoencephalographic (MEG) forward or inverse sim ulations in realistic head models. We verify the accuracy, in an inhomogeneous, nonspherical realistic head model, the magnetic field normal to the MEG detector due to volume

  3. Heatup of the TMI-2 lower head during core relocation

    SciTech Connect (OSTI)

    Wang, S.K.; Sienicki, J.J.; Spencer, B.W.

    1989-01-01T23:59:59.000Z

    An analysis has been carried out to assess the potential of a melting attack upon the reactor vessel lower head and incore instrument nozzle penetration weldments during the TMI core relocation event at 224 minutes. Calculations were performed to determine the potential for molten corium to undergo breakup into droplets which freeze and form a debris bed versus impinging upon the lower head as one or more coherent streams. The effects of thermal-hydraulic interactions between corium streams and water inside the lower plenum, the effects of the core support assembly structure upon the corium, and the consequences of corium relocation by way of the core former region were examined. 19 refs., 24 figs.

  4. Integrated hydraulic cooler and return rail in camless cylinder head

    DOE Patents [OSTI]

    Marriott, Craig D. (Clawson, MI); Neal, Timothy L. (Ortonville, MI); Swain, Jeff L. (Flushing, MI); Raimao, Miguel A. (Colorado Springs, CO)

    2011-12-13T23:59:59.000Z

    An engine assembly may include a cylinder head defining an engine coolant reservoir, a pressurized fluid supply, a valve actuation assembly, and a hydraulic fluid reservoir. The valve actuation assembly may be in fluid communication with the pressurized fluid supply and may include a valve member displaceable by a force applied by the pressurized fluid supply. The hydraulic fluid reservoir may be in fluid communication with the valve actuation assembly and in a heat exchange relation to the engine coolant reservoir.

  5. Development of Power-head based Fan Airflow Station

    E-Print Network [OSTI]

    Wang, G.; Liu, M.

    2005-01-01T23:59:59.000Z

    related to the measured fan speed. Actually the measured fan speed is assumed to equal the motor synchronous speed, which is proportional to the VFD frequency. Theoretically it is not true. The difference between the synchronous speed and motor speed... the basic theory, experiment and results of the power-head based airflow station. Theory Figure 1 shows variable speed fan connection schematic. VFD is normally installed on the motor to adjust the motor speed by modulating frequency. Typically...

  6. Reactor pressure vessel head vents and methods of using the same

    DOE Patents [OSTI]

    Gels, John L; Keck, David J; Deaver, Gerald A

    2014-10-28T23:59:59.000Z

    Internal head vents are usable in nuclear reactors and include piping inside of the reactor pressure vessel with a vent in the reactor upper head. Piping extends downward from the upper head and passes outside of the reactor to permit the gas to escape or be forcibly vented outside of the reactor without external piping on the upper head. The piping may include upper and lowers section that removably mate where the upper head joins to the reactor pressure vessel. The removable mating may include a compressible bellows and corresponding funnel. The piping is fabricated of nuclear-reactor-safe materials, including carbon steel, stainless steel, and/or a Ni--Cr--Fe alloy. Methods install an internal head vent in a nuclear reactor by securing piping to an internal surface of an upper head of the nuclear reactor and/or securing piping to an internal surface of a reactor pressure vessel.

  7. Supplement 22, Part 6, Section A. Subject Headings: A-I, Parasite-Subject Catalogue, Subject Headings and Treatment

    E-Print Network [OSTI]

    Zidar, Judith A.; Shaw, Judith H.; Hanfman, Deborah T.; Kirby, Margie D.; Rayburn, Jane D.; Edwards, Shirley J.; Hood, Martha W.

    1979-01-01T23:59:59.000Z

    other products not mentioned. SUBJECT HEADINGS 1 Abnormalities. See Anomalies. Abortion Arnaudov, D.; et al., 1976, Vet. Med., Praha, v. 49, v. 21 (6), 375-384 Toxoplasma gondii, sheep, immunoepizootio- logical study by hemagglutination, indirect... fluorescence, and microprecipitation reaction in agar gel; higher incidence in aborting ewes and in sheep in montane regions : Bul- garia; Czechoslovakia Abortion Donev, ?., 1975, Vet. Med. Nauki, v. 12 (1), 64-68 final results of pregnancy in 5 flocks...

  8. Extreme high-head portables provide more pumping options

    SciTech Connect (OSTI)

    Fiscor, S.

    2006-10-15T23:59:59.000Z

    Three years ago, Godwin Pumps, one of the largest manufacturers of portable pumps, introduced its Extreme Duty High Lift (HL) series of pumps and more mines are finding unique applications for these pumps. The Extreme HL series is a range single-stage Dri-Prime pumps with heads up to 600 feet and flows up to 5,000 gallons per minute. The American Coal Co.'s Galatia mine, an underground longwall mine in southern Illinois, used an HL 160 to replace a multiple-staged centrifugal pump. It provided Galatia with 1,500 gpm at 465 ft. 3 photos.

  9. Los Alamos names new head of stockpile manufacturing and support

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn12electron 9 5LetLooking5invests inLos Alamos honorsNew head

  10. Owls Head, Maine: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I Geothermal Pwer PlantMunhall,Missouri:EnergyOssian, New York: EnergyOuachitaOwasso,Owls Head, Maine: Energy

  11. MHK Projects/Brough Head Wave Farm | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to: navigation, searchOf KilaueaInformation Other4Q07)AKBrough Head Wave Farm < MHK

  12. Head of EM Visits Northwest Tribes | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEN TO THEHudson Hazle Spindle, LLC BeaconHead of

  13. Bear Head Lake, Minnesota: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:EzfeedflagBiomass Conversions IncBay County, Florida:Tyngsboro, MassachusettsCreek,Head Lake,

  14. Heading Lock Maneuver Testing of Autonomous Underwater Vehicle

    E-Print Network [OSTI]

    Muljowidodo, K

    2008-01-01T23:59:59.000Z

    In recent years, Autonomous Underwater Vehicle (UAV) research and development at Bandung Institute of Technology in Indonesia has achieved the testing stage in the field. This testing was still being classified as the early testing, since some of the preliminary tests were carried out in the scale of the laboratory. The paper would discuss the laboratory test and several tests that were done in the field. Discussions were stressed in the procedure and the aim that will be achieved, along with several early results. The testing was carried out in the lake with the area around 8300 Ha and the maximum depth of 50 meters. The location of the testing was chosen with consideration of minimizing the effect of the current and the wave, as well as the location that was not too far from the Laboratory. The type of testing that will be discussed in paper was Heading Lock Maneuver Testing. The vehicle was tested to move with a certain cruising speed, afterwards it was commanded by an arbitrarily selected heading directio...

  15. Quantum phase estimation using a multi-headed cat state

    E-Print Network [OSTI]

    Su-Yong Lee; Chang-Woo Lee; Hyunchul Nha; Dagomir Kaszlikowski

    2015-05-16T23:59:59.000Z

    It was recently shown that an entangled coherent state, which is a superposition of two different coherent states, can surpass the performance of noon state in estimating an unknown phase-shift. This may hint at further enhancement in phase estimation by incorporating more component states in the superposition of resource state. We here introduce a four-headed cat state (4HCS), a superposition of four different coherent states, and propose its application to quantum phase estimation. We demonstrate the enhanced performance in phase estimation by employing an entangled state via the 4HCS, which can surpass that of the two-headed cat state (2HCS), particularly in the regime of small average photon numbers. Moreover, we show that an entangled state modified from the 4HCS can further enhance the phase estimation, even in the regime of large average photon number under a photon-loss channel. Our investigation further extends to incorporate an increasingly large number of component states in the resource superposition state and clearly show its merit in phase estimation.

  16. Post-Cretaceous faulting at head of Mississippi embayment

    SciTech Connect (OSTI)

    Nelson, W.J. (Illinois State Geological Survey, Champaign, IL (United States)); Harrison, R.W. (Geological Survey, Reston, VA (United States))

    1993-03-01T23:59:59.000Z

    Recent mapping in southernmost Illinois and southeastern Missouri has revealed numerous faults that displace Cretaceous and Tertiary strata. Units as young as the Pliocene-Pleistocene( ) Mounds Gravel are deformed; some faults possibly displace Quaternary sediments. The faults strike northeast, dip nearly vertically, and exhibit characteristics of dextral strike-slip. Pull-apart grabens occur along right-stepping fault strands, they contain chaotically jumbled blocks of Paleozoic, Cretaceous and Tertiary rocks downdropped as much as 800 m relative to wall rocks. Faults at the head of the Mississippi embayment probably originated during Cambrian rifting (Reelfoot rift) and have a long, complex history of reactivation under different stress fields. Some faults are on strike with faults in the New Madrid seismic zone. Kinematics of post-Cretaceous displacements fit the contemporary stress regime of ENE-WSW compression. Similar fault orientations and kinematics, as well as close proximity, suggest a close link between faulting at the head of the embayment and ongoing tectonism in the New Madrid seismic zone.

  17. Imaging system for cardiac planar imaging using a dedicated dual-head gamma camera

    DOE Patents [OSTI]

    Majewski, Stanislaw (Morgantown, VA); Umeno, Marc M. (Woodinville, WA)

    2011-09-13T23:59:59.000Z

    A cardiac imaging system employing dual gamma imaging heads co-registered with one another to provide two dynamic simultaneous views of the heart sector of a patient torso. A first gamma imaging head is positioned in a first orientation with respect to the heart sector and a second gamma imaging head is positioned in a second orientation with respect to the heart sector. An adjustment arrangement is capable of adjusting the distance between the separate imaging heads and the angle between the heads. With the angle between the imaging heads set to 180 degrees and operating in a range of 140-159 keV and at a rate of up to 500kHz, the imaging heads are co-registered to produce simultaneous dynamic recording of two stereotactic views of the heart. The use of co-registered imaging heads maximizes the uniformity of detection sensitivity of blood flow in and around the heart over the whole heart volume and minimizes radiation absorption effects. A normalization/image fusion technique is implemented pixel-by-corresponding pixel to increase signal for any cardiac region viewed in two images obtained from the two opposed detector heads for the same time bin. The imaging system is capable of producing enhanced first pass studies, bloodpool studies including planar, gated and non-gated EKG studies, planar EKG perfusion studies, and planar hot spot imaging.

  18. In search of a new governing failure criterion for torispherical heads

    SciTech Connect (OSTI)

    Kalnins, A.; Updike, D.P. [Lehigh Univ., Bethlehem, PA (United States); Rana, M.D. [Praxair, Inc., Tonawanda, NY (United States). Research and Development Dept.

    1995-12-01T23:59:59.000Z

    The failure criterion that governs the present design rules of formed heads in Section 8/Div. 2 of the ASME B and PV Code limits crown displacement upon a single application of pressure, and it does so by means of a calculated collapse pressure. One problem with the rules is that they require greater head thicknesses than those of Section 8/Div. 1. Another problem is that recent test data taken for two formed heads have shown no signs of head displacements or deformations that could have rendered the heads unserviceable at pressures substantially higher than the calculated collapse pressures. Any link between the calculated collapse pressures and the failures of the test heads could not be established. The main thesis proposed in the paper is that such a link does not exist for torispherical heads in general. The reason for this is investigated theoretically and attributed to the geometric strengthening of heads, as they deform. It is recommended that the reasons for limiting displacements or deformations for a single application of pressure be reviewed and, if needed, a new failure criterion defined, or other failure modes, such as tensile plastic instability (burst), be considered. The latter mode is described and options for its evaluation are presented in this paper. The protection of torispherical heads against the failure modes of low-cycle fatigue and incremental plastic growth upon cyclic loading, which are controlled by shakedown, is not covered in this paper but is left to future investigations.

  19. advanced head-and-neck cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in skin cancer, colorectal carcinoma, testicular teratoma and liver cancer types: brain, breast, head and neck, renal, skin and testicular cancers. Conclusions: SULF1 and...

  20. Japan`s refiner/marketers headed for major shakeout

    SciTech Connect (OSTI)

    NONE

    1996-08-26T23:59:59.000Z

    Japan`s downstream oil industry is in a state of crisis and headed for a major shakeout. The major catalyst for this was a dramatic deregulation step during April 1996 that allowed refined petroleum product imports by non-refiners. The move, together with a sharp drop in refining margins, falling retail gasoline prices, and a service station sector on the brink of collapse, are all leading to massive changes in the way the country`s refiners and marketers do business. This paper reviews the collapse of corporate profits during this period of deregulation; the development of a new price system geared toward bringing the prices of gasoline, fuel oil, and kerosene into line with each other to offset the fall in gasoline prices; and industry restructuring including mergers, acquisitions, and marketing consolidation. The paper then makes predictions on the outcome of these changes on the Japanese oil industry.

  1. Frankie Phua Executive Director and Head of Credit & Country Risk Management Division

    E-Print Network [OSTI]

    Chaudhuri, Sanjay

    Frankie Phua Executive Director and Head of Credit & Country Risk Management Division UOB Frankie Phua is the Executive Director and the Global Head of the Credit & Country Risk Management Division (PD, LGD and EAD), economic capital modelling, credit portfolio risk management, counterparty credit

  2. To Tilt Your Head or Not To: Potentially Bijoy K. Ghosh and Indika Wijayasinghe

    E-Print Network [OSTI]

    Ghosh, Bijoy K.

    heading directions, as a simple mechanical control system. Head movements obey Donders' constraint (as Systems, Texas Tech University, Lubbock, Texas, USA indika.wijayasinghe@ttu.edu the control of eye treatment of the topic in the framework of modern control theory and geometric mechanics. Assuming the eye

  3. Maximum Running Speed of Captive Bar-Headed Geese Is Unaffected by Severe Hypoxia

    E-Print Network [OSTI]

    Scott, Graham

    of Zoology, University of British Columbia, Vancouver, Canada, 6 Department of Biology, McMaster University lower than bar-headed geese. In bar-headed geese, partial pressures of oxygen and carbon dioxide in both Research Council (BBSRC) of the United Kingdom [Grant number BB/F015615/1] to CMB and PJB. The funders had

  4. FAST MULTIPOLE ACCELERATED BOUNDARY ELEMENTS FOR NUMERICAL COMPUTATION OF THE HEAD RELATED TRANSFER FUNCTION

    E-Print Network [OSTI]

    Zotkin, Dmitry N.

    FAST MULTIPOLE ACCELERATED BOUNDARY ELEMENTS FOR NUMERICAL COMPUTATION OF THE HEAD RELATED TRANSFER with measure- ments are also difficult. We present a fast multipole based iterative preconditioned Krylov are presented. Index Terms-- Head related transfer function, Boundary ele- ment method, Fast Multipole Method

  5. Model Predictive Tracking Control for a Head-Positioning in a Hard-Disk-Drive

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Model Predictive Tracking Control for a Head-Positioning in a Hard-Disk-Drive M. Taktak-Meziou, A generated from Model Predictive Control (MPC). The first approach consists of a classical linear MPC without/Write (R/W) head of a Hard-Disk-Drive (HDD) servo-system, which is resolved with two control algorithms

  6. Tumor delineation using PET in head and neck cancers: Threshold contouring and lesion volumes

    E-Print Network [OSTI]

    Yetisgen-Yildiz, Meliha

    PET/CT patient images. The intensity value of the threshold contour level that returns 100Tumor delineation using PET in head and neck cancers: Threshold contouring and lesion volumes Eric as a function of the reconstruction method, smoothing, and lesion size in head and neck cancer patients using

  7. Pre-clinical evaluation of ceramic femoral head resurfacing prostheses using computational models and

    E-Print Network [OSTI]

    .534 kN to 5.34 kN. In worst- case tests representing a complete lack of superior femoral head bonePre-clinical evaluation of ceramic femoral head resurfacing prostheses using computational models in resurfacing hip replacement (RHR) have been reported as early femoral neck fracture, infection, and loosening

  8. Running head: Eye-tracking in chimpanzees and humans 1 Research Article9

    E-Print Network [OSTI]

    Takada, Shoji

    #12;Running head: Eye-tracking in chimpanzees and humans 1 1 2 3 4 5 6 7 8 Research Article915 16 fkanou@pri.kyoto-u.ac.jp17 +81-80-6902-501318 19 #12;Running head: Eye-tracking in chimpanzees and humans 2 Abstract20 Previous studies comparing eye movements between humans and their closest relatives

  9. Running head: GEOTHERMAL POWER PRODUCTION 1 Geothermal Power Production for Emmonak, Alaska

    E-Print Network [OSTI]

    Scheel, David

    Running head: GEOTHERMAL POWER PRODUCTION 1 Geothermal Power Production for Emmonak, Alaska Anthony Bryant Senior Project Alaska Pacific University May 5, 2010 #12;Running head: GEOTHERMAL POWER PRODUCTION January 2009. This paper researches the possibility of using geothermal energy as an alternative energy

  10. Audio-based Head Motion Synthesis for Avatar-based Telepresence Systems

    E-Print Network [OSTI]

    Busso, Carlos

    ]: Three Dimensional Graphics and Realism-Animation, Virtual Reality; I.2.6 [Artificial Intelligence, Design, Experimentation, Human Factors Keywords Computer Graphics, Facial Animation, Data-driven, Head- thesis technique is presented for avatar-based telepresence systems. First, head motion of a human

  11. Ensemble smoother assimilation of hydraulic head and return flow data to estimate hydraulic conductivity distribution

    E-Print Network [OSTI]

    Bau, Domenico A.

    Ensemble smoother assimilation of hydraulic head and return flow data to estimate hydraulic and data measurements, an ensemble smoother (ES) to provide enhanced estimates of aquifer hydraulic conductivity (K) through assimilation of hydraulic head (H) and groundwater return flow volume (RFV

  12. The Point Spread Function of the Human Head and its Implications for Transcranial Current

    E-Print Network [OSTI]

    Parra, Lucas C.

    The Point Spread Function of the Human Head and its Implications for Transcranial Current distribution in the head resulting from the application of scalp currents. Derivation of forward models has represented a major effort in brain stimulation research, with model complexity ranging from spherical shells

  13. The Rotational Propulsion Characteristics of Scaled-up Helical Microswimmers with different heads and magnetic positioning

    E-Print Network [OSTI]

    of the cut-off frequency. The rotational propulsion characteristics of helical swimmers with a magnetic headThe Rotational Propulsion Characteristics of Scaled-up Helical Microswimmers with different heads and magnetic positioning Tiantian Xu1, Gilgueng Hwang2, Nicolas Andreff3 and Stephane Regnier1 Abstract

  14. Experimental measurement of human head motion for high-resolution computed tomography

    E-Print Network [OSTI]

    Wang, Ge

    Experimental measurement of human head motion for high-resolution computed tomography system design experimentally measured for high-resolution computed tomography CT design using a Canon digital camera. Our goal-Optical Instrumentation Engineers. DOI: 10.1117/1.3454379 Subject terms: head motion; computed tomography CT ; image

  15. INTERNAL PROJECT INFORMATION NOTE 10/08 Title: CCF Harvesting Method Development: Harvester Head

    E-Print Network [OSTI]

    INTERNAL PROJECT INFORMATION NOTE 10/08 Title: CCF Harvesting Method Development: Harvester Head PROJECT INFORMATION NOTE 10/08 Ref 1200A/56/07 CCF Harvesting Method Development: Harvester Head Visibility SUMMARY The use of Continuous Cover Forestry (CCF) can lead to situations where a dense

  16. Nuclear Engineering and Design 189 (1999) 757 Lower head integrity under steam explosion loads

    E-Print Network [OSTI]

    Yuen, Walter W.

    Nuclear Engineering and Design 189 (1999) 7­57 Lower head integrity under steam explosion loads T Received 24 August 1998; accepted 24 November 1998 Abstract Lower head integrity under steam explosion is `physically unreasonable'. © 1999 Elsevier Science S.A. All rights reserved. Keywords: Steam explosions

  17. &p.1:Abstract We reviewed 24 hips with avascular necrosis of the femoral head in 24 patients treated with vascular-

    E-Print Network [OSTI]

    Iglic, Ales

    was to evaluate the treatment of femoral head necrosis using a vascularized iliac crest bone graft. Materials&p.1:Abstract We reviewed 24 hips with avascular necrosis of the femoral head in 24 patients and early Stage III, when necrosis does not yet involve the complete femoral head. &p.1:Rsum Nous avons

  18. In vivo evaluation of wearable head impact sensors

    E-Print Network [OSTI]

    Wu, Lyndia C; Bui, Kevin; Hammoor, Bradley; Kurt, Mehmet; Hernandez, Fidel; Kuo, Calvin; Camarillo, David B

    2015-01-01T23:59:59.000Z

    Human skull accelerations are difficult to measure due to imperfect skull coupling. Some approaches have been validated with dummy or cadaver experiments, but methods to evaluate sensors in vivo are lacking. Here we present a novel method using high speed video to evaluate teeth-mounted (mouthguard), soft tissue-mounted (skin patch), and headgear-mounted (skull cap) sensors during 5-10g sagittal soccer head impacts. Skull coupling is quantified by displacement from an ear-canal reference. Mouthguard displacements were within video measurement error (<1mm), while the skin patch and skull cap displaced up to 4mm and 13mm from the ear-canal reference, respectively. With close skull-coupling, we used the mouthguard as the reference to assess 6-degree-of-freedom skin patch and skull cap measurements. Linear and rotational acceleration magnitudes were over-predicted by both the skin patch (23+/-9g, 2500+/-1200rad/s^2) and the skull cap (74+/-50g, 4300+/-2700rad/s^2). Such over-predictions were largely due to out...

  19. Quantum phase estimation using a multi-headed cat state

    E-Print Network [OSTI]

    Su-Yong Lee; Chang-Woo Lee; Hyunchul Nha; Dagomir Kaszlikowski

    2015-03-12T23:59:59.000Z

    It was recently shown that an entangled coherent state, which is a superposition of two different coherent states, can surpass the performance of N00N state in estimating an unknown phase-shift. This may hint at further enhancement in phase estimation by incorporating more component states in the superposition of resource state. We here study a four-headed cat state (4HCS), a superposition of four different coherent states, and propose its application to quantum phase estimation. We first investigate how the 4HCS is more nonclassical than a 2HCS in view of some nonclassical measures including sub-Poissonian statistics, negativity of Wigner distribution, and entanglement potential. We then demonstrate the enhanced performance in phase estimation by employing an entangled state via the 4HCS, which can surpass that of the 2HCS particularly in the regime of small average photon number. Moreover, we show that an entangled state modified from the 4HCS can further enhance the phase estimation even in the regime of large average photon number under a photon-loss channel. Our investigation further extends to incorporate an increasingly large number of component states in the resource superposition state and clearly show its merit in phase estimation.

  20. RUNNING HEAD: Balkanization of Probability Balkanization and Unification of Probabilistic Inferences

    E-Print Network [OSTI]

    Yu, Alex

    RUNNING HEAD: Balkanization of Probability Balkanization and Unification of Probabilistic;Balkanization of Probability 2 Abstract Many research-related classes in social sciences present probability;Balkanization of Probability 3 Balkanization and Unification of Probabilistic Inferences Introduction Use

  1. anne-sylvie catherin head: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 313 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  2. actin-bound myosin heads: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 362 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  3. advanced non-nasopharyngeal head: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ecological analyses. In A. Kirlik (Ed Gray, Wayne 205 Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems Texas A&M University - TxSpace Summary:...

  4. Efficient analysis of ordinal data from clinical trials in head injury

    E-Print Network [OSTI]

    McHugh, Gillian Stephanie

    2012-06-30T23:59:59.000Z

    Many promising Phase II trials have been carried out in head injury however to date there has been no successful translation of the positive results from these explanatory trials into improved patient outcomes in Phase ...

  5. Head Loss Through Fibrous Debris Bed with Different Types of Perforated Strainers

    E-Print Network [OSTI]

    Abdulsattar, Suhaeb S

    2014-05-03T23:59:59.000Z

    and becomes an important cause of head loss through the sump strainer, affecting the Emergency Core Cooling System (ECCS) performance. This study was dedicated to measure the pressure drop across randomly accumulated debris bed on the sump strainer along...

  6. An analytical study of rail grinding optimization for rail-head fatigue defect prevention

    E-Print Network [OSTI]

    Jones, Scott Laurence

    1997-01-01T23:59:59.000Z

    and increased train traffic on the remaining routes. These changes in railroad industry practice have caused an increase in the rate of occurrence of rail head fatigue defects, one potential cause of train derailment. The primary form of maintenance employed...

  7. Probabilistic phonotactics in production 1 Running Head: PROBABILISTIC PHONOTACTICS IN PRODUCTION

    E-Print Network [OSTI]

    Reber, Paul J.

    Probabilistic phonotactics in production 1 Running Head: PROBABILISTIC PHONOTACTICS IN PRODUCTION Phonotactic probability influences speech production Matthew Goldrick and Meredith Larson Department in production 2 Abstract Speakers are faster and more accurate at processing certain sound sequences within

  8. Viewpoint-Invariant Learning and Detection of Human Heads M. Weber W. Einhauser

    E-Print Network [OSTI]

    Perona, Pietro

    Viewpoint-Invariant Learning and Detection of Human Heads M. Weber W. Einh¨auser California on histograms of feature detectors to address the same prob- lem. Burl, Leung, Weber and Perona [1] additionally

  9. Artificial gravity : changing the intensity of coriolis cross-coupled stimulus with head-angle

    E-Print Network [OSTI]

    Adenot, Sophie, 1982-

    2004-01-01T23:59:59.000Z

    Artificial Gravity (AG) created by high-speed rotation is a promising method for preventing the serious deconditioning associated with prolonged exposure to weightlessness. Unfortunately, head-movements in a rotating ...

  10. Emotion Regulation as Situated Conceptualizations 1 RUNNING HEAD: EMOTION REGULATION AS SITUATED CONCEPTUALIZATIONS

    E-Print Network [OSTI]

    Barsalou, Lawrence W.

    Emotion Regulation as Situated Conceptualizations 1 RUNNING HEAD: EMOTION REGULATION AS SITUATED CONCEPTUALIZATIONS TITLE: A psychological construction account of emotion regulation and dysregulation: The role of situated conceptualizations Lisa Feldman Barrett Northeastern University; Massachusetts General Hospital

  11. Application of the cumulative risk model in predicting school readiness in Head Start children

    E-Print Network [OSTI]

    Rodriguez-Escobar, Olga Lydia

    2009-05-15T23:59:59.000Z

    outcomes. This study built on this literature by investigating how child, parent, and family risk factors predicted school readiness in Head Start children using two statistical models. Specific aims of this study included identifying 1) to what degree...

  12. The dynamics of the human head during natural activities that require clear vision

    E-Print Network [OSTI]

    Bates, Warren (Warren W.)

    2006-01-01T23:59:59.000Z

    The current understanding of the dynamics of the human head, and the demands placed on its control and stability systems, is based largely on the results of experiments conducted in artificial settings, such as when subjects ...

  13. TO: Deans, Directors and Department Heads FROM: Charles Eaton, Interim Controller and Director of Accounting

    E-Print Network [OSTI]

    Holsinger, Kent

    TO: Deans, Directors and Department Heads FROM: Charles Eaton, Interim Controller and Director in the current fiscal year. Purchase Requisitions: Purchases under $10,000 (Includes Corporate Express) June 11

  14. Physical and Numerical Space Running Head: Biases in Physical and Numerical Space

    E-Print Network [OSTI]

    Chatterjee, Anjan

    Physical and Numerical Space 1 Running Head: Biases in Physical and Numerical Space Elementary school children's attentional biases in physical and numerical space Tilbe Göksun: April 30, 2012 #12; Physical and Numerical Space 2 Abstract Numbers

  15. Swimming speed and stamina in head started Kemp's ridley sea turtles (Lepidochelys Kempi)

    E-Print Network [OSTI]

    Stabenau, Erich Kurt

    1988-01-01T23:59:59.000Z

    SWIMMING SPEED AND STAMINA IN HEAD STARTED KEMP'S RIDLEY SEA TURTLES (LEPIDOCHELYS KEMPI) A Thesis by ERICH KURT STABENAU Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements for the degree... of MASTER QF SCIENCE August 1988 Major Subject: Wildlife and Fisheries Sciences SWIMMING SPEED AND STAMINA IN HEAD STARTED KEMP'S RIDLEY SEA TURTLES (LEPIDOCHELYS KEMPI) A Thesis by ERICH KURT STABENAU Approved as to style and content by: Andre M...

  16. Classification of brain compartments and head injury lesions by neural networks applied to magnetic resonance images

    E-Print Network [OSTI]

    Kischell, Eric Robert

    1993-01-01T23:59:59.000Z

    ' (Member) A. D. Patton ( ead of epartment) August 1993 Major Subject: Electrical Engineering ABSTRACT Classification of Brain Compartments and Head Injury Lesions by Neural Networks Applied to Magnetic Resonance Images. (August 1993) Eric Robert... Kischell, B. S. , Northeastern University Chair of Advisory Committee: Dr. Nasser Kehtarnavaz An automatic neural network-based approach was ap- plied to segment brain compartments and closed-head-injury lesions in magnetic resonance (MR) images Two...

  17. Effects of Parent Expectations and Involvement on the School Readiness of Children in Head Start

    E-Print Network [OSTI]

    Cook, Krystal Tisha'

    2010-10-12T23:59:59.000Z

    EFFECTS OF PARENT EXPECTATIONS AND INVOLVEMENT ON THE SCHOOL READINESS OF CHILDREN IN HEAD START A Dissertation by KRYSTAL TISHA? COOK Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of children enrolled in Head Start. The study examined how these iv parent variables were related to children?s school readiness, and differences between ethnic groups, gender groups, and level of risk. The study tested a model whereby the effect...

  18. Internal strain regulates the nucleotide binding site of the kinesin leading head

    E-Print Network [OSTI]

    Hyeon, Changbong; 10.1073/pnas.0610939104

    2009-01-01T23:59:59.000Z

    In the presence of ATP, kinesin proceeds along the protofilament of microtubule by alternated binding of two motor domains on the tubulin binding sites. Since the processivity of kinesin is much higher than other motor proteins, it has been speculated that there exists a mechanism for allosteric regulation between the two monomers. Recent experiments suggest that ATP binding to the leading head domain in kinesin is regulated by the rearward strain built on the neck-linker. We test this hypothesis by explicitly modeling a $C_{\\alpha}$-based kinesin structure whose both motor domains are bound on the tubulin binding sites. The equilibrium structures of kinesin on the microtubule show disordered and ordered neck-linker configurations for the leading and the trailing head, respectively. The comparison of the structures between the two heads shows that several native contacts present at the nucleotide binding site in the leading head are less intact than those in the binding site of the rear head. The network of n...

  19. Accelerated Life Structural Benchmark Testing for a Stirling Convertor Heater Head

    SciTech Connect (OSTI)

    Krause, David L. [National Aeronautics and Space Administration, Glenn Research Center, Cleveland, OH 44135 (United States); Kantzos, Pete T. [Ohio Aerospace Institute, NASA Glenn Research Center, Cleveland, OH 44135 (United States)

    2006-01-20T23:59:59.000Z

    For proposed long-duration NASA Space Science missions, the Department of Energy, Lockheed Martin, Infinia Corporation, and NASA Glenn Research Center are developing a high-efficiency, 110-watt Stirling Radioisotope Generator (SRG110). A structurally significant limit state for the SRG110 heater head component is creep deformation induced at high material temperature and low stress level. Conventional investigations of creep behavior adequately rely on experimental results from uniaxial creep specimens, and a wealth of creep data is available for the Inconel 718 material of construction. However, the specified atypical thin heater head material is fine-grained with a heat treatment that limits precipitate growth, and little creep property data for this microstructure is available in the literature. In addition, the geometry and loading conditions apply a multiaxial stress state on the component, far from the conditions of uniaxial testing. For these reasons, an extensive experimental investigation is ongoing to aid in accurately assessing the durability of the SRG110 heater head. This investigation supplements uniaxial creep testing with pneumatic testing of heater head-like pressure vessels at design temperature with stress levels ranging from approximately the design stress to several times that. This paper presents experimental results, post-test microstructural analyses, and conclusions for four higher-stress, accelerated life tests. Analysts are using these results to calibrate deterministic and probabilistic analytical creep models of the SRG110 heater head.

  20. Evaluation of preharvest chemical dessication and module storage of grain sorghum head chop when fed to cattle

    E-Print Network [OSTI]

    Davis, Walter Louis

    1979-01-01T23:59:59.000Z

    EVALUATION OF PHEHARVEST CHEMICAL DESSICATION AND MODULE STORAGE OF GRAIN SORGHUM HEAD CHOP WHEN FED TO CATTLE A Thesis by WALTER LOUIS DAVIS Approved as to style and content bye Chairman of Committee Head of D rtment Member ~c'p Jft ~Is... ~it 8 & ~ Member December 1979 i242841 ABS TRAC T Evaluation of Preharvest Chemical Dessication and Module Storage of Grain Sorghum Head Chop When Fed to Cattle. (December 1979) Walter Louis Davis, B. S. , Texas A&M University Chairman...

  1. Computational evaluation of a novel approach to process planning for circuit card assembly on dual head placement machines

    E-Print Network [OSTI]

    Chowdhury, Nilanjan Dutta

    2006-04-12T23:59:59.000Z

    nozzle that uses vacuum to pick a component. Spindles can be rotated around the z-axis simultaneously, by a common drive motor to achieve proper component orientations. Each head can pick components from a set of two racks, each having 32 feeder.... Two nozzle change racks are also associated with each head. These consist of nozzle pads, which hold different nozzle types. Operation managers pre-assign nozzle types to heads. Nozzles are picked up from the pads by spindles using vacuum...

  2. Routine Repeat Head CT may not be Indicated in Patients on Anticoagulant/Antiplatelet Therapy Following Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    McCammack, Kevin C.; Sadler, Charlotte; Guo, Yueyang; Ramaswamy, Raja S; Farid, Nikdokht

    2015-01-01T23:59:59.000Z

    needed when the computed tomography scan is normal. Acadof noncontrast cranial computed tomography for the emergencyMcCammack et al. Head Computed Tomography anticoagulant and

  3. Routine Repeat Head CT may not be Indicated in Patients on Anticoagulant/Antiplatelet Therapy Following Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    McCammack, Kevin C.; Sadler, Charlotte; Guo, Yueyang; Ramaswamy, Raja S; Farid, Nikdokht

    2015-01-01T23:59:59.000Z

    needed when the computed tomography scan is normal. AcadMcCammack et al. Head Computed Tomography anticoagulant andof sequential computed tomography scanning in anticoagulated

  4. Stability of Single Particle Motion with Head-On Beam-Beam Compensation in the RHIC

    SciTech Connect (OSTI)

    Luo,Y.; Fischer, W.; Abreu, N.

    2008-05-01T23:59:59.000Z

    To compensate the large tune shift and tune spread generated by the head-on beam-beam interactions in the polarized proton run in the Relativistic Heavy Ion Collider (RHIC), we proposed a low energy electron beam with a Gaussian transverse profiles to collide head-on with the proton beam. In this article, with a weak-strong beam-beam interaction model, we investigate the stability of single particle motion in the presence of head-on beam-beam compensation. Tune footprints, tune diffusion, Lyapunov exponents, and 10{sup 6} turn dynamic apertures are calculated and compared between the cases without and with beam-beam compensation. A tune scan is performed and the possibility of increasing the bunch intensity is studied. The cause of tune footprint foldings is discussed, and the tune diffusion and Lyapunov exponent analysis are compared.

  5. Evaluating the Impact of Head Rotation Amplification on Virtual Reality Training Effectiveness

    SciTech Connect (OSTI)

    Ragan, Eric D [ORNL] [ORNL; Bowman, Doug A [Virginia Polytechnic Institute and State University] [Virginia Polytechnic Institute and State University; Scerbo, Siroberto [Virginia Polytechnic Institute and State University] [Virginia Polytechnic Institute and State University; Bacim, Felipe [Virginia Polytechnic Institute and State University] [Virginia Polytechnic Institute and State University

    2013-01-01T23:59:59.000Z

    Virtual reality (VR) systems have been proposed for use in numerous training scenarios, such as room clearing, which require the trainee to maintain spatial awareness. But many VR training systems lack a fully surrounding display, requiring trainees to use a combination of physical and virtual turns to view the environment, thus decreasing spatial awareness. One solution to this problem is to amplify head rotations, such that smaller physical turns are mapped to larger virtual turns, allowing trainees to view the surrounding environment with head movements alone. For example, in a multi-monitor system covering only a 90-degree field of regard, head rotations could be amplified four times to allow the user to see the entire 360-degree surrounding environment. This solution is attractive because it can be used with lower-cost VR systems and does not require virtual turning. However, the effects of amplified head rotations on spatial awareness and training transfer are not well understood. We hypothesized that small amounts of amplification might be tolerable, but that larger amplifications might cause trainees to become disoriented and to have decreased task performance and training transfer. In this paper, we will present our findings from an experiment designed to investigate these hypotheses. The experiment placed users in a virtual warehouse and asked them to move from room to room, counting objects placed around them in space. We varied the amount of amplification applied during these trials, and also varied the type of display used (head-mounted display or CAVE). We measured task performance and spatial awareness. We then assessed training transfer in an assessment environment with a fully surrounding display and no amplification. The results of this study will inform VR training system developers about the potential negative effects of using head rotation amplification and contribute to more effective VR training system design.

  6. Internal combuston engine having separated cylinder head oil drains and crankcase ventilation passages

    DOE Patents [OSTI]

    Boggs, D.L.; Baraszu, D.J.; Foulkes, D.M.; Gomes, E.G.

    1998-12-29T23:59:59.000Z

    An internal combustion engine includes separated oil drain-back and crankcase ventilation passages. The oil drain-back passages extend from the cylinder head to a position below the top level of oil in the engine`s crankcase. The crankcase ventilation passages extend from passages formed in the main bearing bulkheads from positions above the oil level in the crankcase and ultimately through the cylinder head. Oil dams surrounding the uppermost portions of the crankcase ventilation passages prevent oil from running downwardly through the crankcase ventilation passages. 4 figs.

  7. Internal combuston engine having separated cylinder head oil drains and crankcase ventilation passages

    DOE Patents [OSTI]

    Boggs, David Lee (Bloomfield Hills, MI); Baraszu, Daniel James (Plymouth, MI); Foulkes, David Mark (Erfstadt, DE); Gomes, Enio Goyannes (Ann Arbor, MI)

    1998-01-01T23:59:59.000Z

    An internal combustion engine includes separated oil drain-back and crankcase ventilation passages. The oil drain-back passages extend from the cylinder head to a position below the top level of oil in the engine's crankcase. The crankcase ventilation passages extend from passages formed in the main bearing bulkheads from positions above the oil level in the crankcase and ultimately through the cylinder head. Oil dams surrounding the uppermost portions of the crankcase ventilation passages prevent oil from running downwardly through the crankcase ventilation passages.

  8. Modeling of an eye-imaging system for optimizing illumination schemes in an eye-tracked head-mounted

    E-Print Network [OSTI]

    Hua, Hong

    Modeling of an eye-imaging system for optimizing illumination schemes in an eye-tracked head While the augmentation of head-mounted displays (HMDs) with eye-tracking (ET) capabilities adds of illumination schemes in an ET-HMD system, we present a simulated eye illumination and imaging system, which

  9. Influence of tissue conductivity anisotropy on EEG/MEG field and return current computation in a realistic head model

    E-Print Network [OSTI]

    Utah, University of

    brain using potential differences and/or magnetic fluxes measured non- invasively directly from the head in a realistic head model: A simulation and visualization study using high-resolution finite element modeling C 3493, Salt Lake City, UT 84112, USA c Max Planck Institute for Human Cognitive and Brain Sciences

  10. Talk to the Virtual Hands: Self-Animated Avatars Improve Communication in Head-Mounted Display Virtual

    E-Print Network [OSTI]

    Talk to the Virtual Hands: Self-Animated Avatars Improve Communication in Head-Mounted Display Virtual Environments Trevor J. Dodds1 *, Betty J. Mohler1 , Heinrich H. Bu lthoff1,2 1 Human Perceptionlthoff HH (2011) Talk to the Virtual Hands: Self-Animated Avatars Improve Communication in Head

  11. CASING-HEADING PHENOMENON IN GAS-LIFTED WELL AS A LIMIT CYCLE OF A

    E-Print Network [OSTI]

    phenomenon occurring on gas- lift artificially lifted well. This behavior is well represented by a 2D model: Process Control, Dynamic Systems, Limit Cycles, Switching System, Gas-Lifted Well. 1. INTRODUCTIONCASING-HEADING PHENOMENON IN GAS-LIFTED WELL AS A LIMIT CYCLE OF A 2D MODEL WITH SWITCHES Laure Sin

  12. UNITED INDIA INSURANCE COMPANY LIMITED REGISTERED & HEAD OFFICE: 24, WHITES ROAD, CHENNAI-600014

    E-Print Network [OSTI]

    Dhingra, Narender K.

    UNITED INDIA INSURANCE COMPANY LIMITED REGISTERED & HEAD OFFICE: 24, WHITES ROAD, CHENNAI-600014 HEALTH INSURANCE POLICY ­ GROUP 1 WHEREAS the insured designated in the Schedule hereto has by a proposal to be incorporated herein has applied to UNITED INDIA INSURANCE COMPANY LTD. (hereinafter called the COMPANY

  13. Optimizing Cluster Heads for Energy Efficiency in Large-Scale Heterogeneous Wireless Sensor Networks

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Gu, Yi; Wu, Qishi; Rao, Nageswara S. V.

    2010-01-01T23:59:59.000Z

    Many complex sensor network applications require deploying a large number of inexpensive and small sensors in a vast geographical region to achieve quality through quantity. Hierarchical clustering is generally considered as an efficient and scalable way to facilitate the management and operation of such large-scale networks and minimize the total energy consumption for prolonged lifetime. Judicious selection of cluster heads for data integration and communication is critical to the success of applications based on hierarchical sensor networks organized as layered clusters. We investigate the problem of selecting sensor nodes in a predeployed sensor network to be the cluster heads tomoreminimize the total energy needed for data gathering. We rigorously derive an analytical formula to optimize the number of cluster heads in sensor networks under uniform node distribution, and propose a Distance-based Crowdedness Clustering algorithm to determine the cluster heads in sensor networks under general node distribution. The results from an extensive set of experiments on a large number of simulated sensor networks illustrate the performance superiority of the proposed solution over the clustering schemes based onk-means algorithm.less

  14. IMPLICIT EVALUATION OF EMOTION REGULATION 1 Running Head: IMPLICIT EVALUATION OF EMOTION REGULATION

    E-Print Network [OSTI]

    Gross, James J.

    IMPLICIT EVALUATION OF EMOTION REGULATION 1 Running Head: IMPLICIT EVALUATION OF EMOTION REGULATION How to Bite Your Tongue without Blowing Your Top: Implicit Evaluation of Emotion Regulation Predicts EVALUATION OF EMOTION REGULATION 2 Abstract People frequently have to control their emotions to function

  15. Mind Perception and Objectification 1 Running Head: Mind Perception and Objectification

    E-Print Network [OSTI]

    Knobe, Joshua

    Mind Perception and Objectification 1 Running Head: Mind Perception and Objectification More than a Body: Mind Perception and the Nature of Objectification Kurt Gray1, Joshua Knobe2, Mark Sheskin2, Paul@umd.edu #12;Mind Perception and Objectification 2 Abstract According to models of objectification, viewing

  16. Dangers of Unilateral Forgiveness 1 Running head: DANGERS OF UNILATERAL FORGIVENESS

    E-Print Network [OSTI]

    Reber, Paul J.

    Dangers of Unilateral Forgiveness 1 Running head: DANGERS OF UNILATERAL FORGIVENESS On the Dangers Northwestern University Word Count: 5096 #12;Dangers of Unilateral Forgiveness 2 On the Dangers of Resolving forgiveness helps victims preserve a relationship #12;Dangers of Unilateral Forgiveness 3 that is likely

  17. Stereotype threat in sports 1 Running head: STEREOTYPE THREAT AND ACHIEVEMENT GOALS IN SPORTS

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Stereotype threat in sports 1 Running head: STEREOTYPE THREAT AND ACHIEVEMENT GOALS IN SPORTS Do Achievement Goals Mediate Stereotype Threat? An Investigation on Females' Soccer Performance Ana Chalabaev Psycholoy 30 (2008) 143-158" #12;Stereotype threat in sports 2 Abstract This research investigated

  18. Running head: STEREOTYPE THREAT REDUCES MEMORY ERRORS Stereotype threat can reduce older adults' memory errors

    E-Print Network [OSTI]

    Mather, Mara

    Running head: STEREOTYPE THREAT REDUCES MEMORY ERRORS Stereotype threat can reduce older adults, 90089-0191. Phone: 213-740-6772. Email: barbersa@usc.edu #12;STEREOTYPE THREAT REDUCES MEMORY ERRORS 2 Abstract (144 words) Stereotype threat often incurs the cost of reducing the amount of information

  19. Promoting Self Directed Learning 1 Running head: PROMOTING SELF DIRECTED LEARNING

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    as incompatible. This is due to the origins of both types of learning environments which, when consideredPromoting Self Directed Learning 1 Running head: PROMOTING SELF DIRECTED LEARNING Promoting Self Directed Learning in Simulation Based Discovery Learning Environments through Intelligent Support Koen

  20. Making the abstract concrete 1 Running head: VISUALIZING MATHEMATICAL SOLUTION PROCEDURES

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Making the abstract concrete 1 Running head: VISUALIZING MATHEMATICAL SOLUTION PROCEDURES Making the Abstract Concrete: Visualizing Mathematical Solution Procedures Katharina Scheiter University of Tuebingen) (2006) 9-25" DOI : 10.1016/j.chb.2005.01.009 #12;Making the abstract concrete 2 Abstract This article

  1. Running head: CONCRETE PROSOCIAL GOALS MAXIMIZE HAPPINESS 1 Getting the Most out of Giving

    E-Print Network [OSTI]

    Bogyo, Matthew

    Running head: CONCRETE PROSOCIAL GOALS MAXIMIZE HAPPINESS 1 Getting the Most out of Giving: Concretely Framing a Prosocial Goal Maximizes Happiness Melanie Rudda University of Houston Jennifer Aakerb Melcher Hall, Houston, TX 77204-6021; Email: mrrudd@bauer.uh.edu; Phone: 713.743.4572. #12;CONCRETE

  2. Agricultural Biotechnology: What's all the fuss about? Marshall A. Martin,* Professor and Associate Head

    E-Print Network [OSTI]

    it mean for soci- ety? And, where are we headed? This article provides background on biotechnologyAgricultural Biotechnology: What's all the fuss about? Marshall A. Martin,* Professor and Associate in the news media, in agribusiness boardrooms, among consumer and environmental activist groups, among

  3. Heatup of the TMI-2 (Three Mile Island Unit 2) lower head during core relocation

    SciTech Connect (OSTI)

    Wang, S.K.; Sienicki, J.J.; Spencer, B.W. (Argonne National Laboratory, IL (USA))

    1989-11-01T23:59:59.000Z

    According to current perceptions of the Three Mile Island Unit 2 (TMI-2) accident, corium largely relocated into the reactor vessel lower head at {approximately}224 min into the accident. Defueling examinations have revealed that the corium relocated from the molten core region to the lower head predominantly by way of drainage through the core former region (CFR) located between the vertical baffle plates immediately surrounding the fuel assemblies and the core barrel. An analysis has been carried out to assess the heatup of the reactor vessel lower head during the core relocation event, particularly the potential for a melting attack on the lower head wall and the in-core instrument nozzle penetration weldments. The analysis employed the THIRMAL computer code developed at Argonne National Laboratory (ANL) to predict the breakup and quenching or corium jets under film boiling conditions as well as the size distributions and quenching of the resultant molten droplets. The transient heatup and ablation of the vessel wall and penetration weldments due to impinging corium jets was calculated using the MISTI computer code.

  4. Classifying Facial Gestures in Presence of Head Motion Wei-Kai Liao and Isaac Cohen

    E-Print Network [OSTI]

    Cohen, Issac

    -computer interaction. Besides, it has many other potential applications, such as virtual reality and facial animation. After estimating the head pose, the human face is modeled by a collection of face's regions vector machine. Our experiments show that this approach could classify human expressions in interactive

  5. Identity and Leadership 1 running head: Psychoanalytic Dialogues of Identity and Leadership

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Identity and Leadership 1 running head: Psychoanalytic Dialogues of Identity and Leadership Identities and Ideals: Psychoanalytic Dialogues of Self and Leadership Gazi Islam Associate Professor,version1-21Mar2014 #12;Identity and Leadership 2 Abstract The author contextualizes recent developments

  6. A systematic review of clinical decision rules in the management of adult minor head injury

    E-Print Network [OSTI]

    Oakley, Jeremy

    is the diagnostic standard for identifying intracranial injury. Routine CT of all minor head injury patients would or APi). Twenty-two articles, representing nineteen studies, were identified. The median prevalence.5%). Patient selection, use of reference standards and outcome definitions all varied. These variations

  7. MEDIA RELEASE --John Herbert, Head of Digital Technologies, J. Willard Marriott Library, University of Utah,

    E-Print Network [OSTI]

    Capecchi, Mario R.

    MEDIA RELEASE Contacts: --John Herbert, Head of Digital Technologies, J. Willard Marriott Library Maps at the University of Utah's J. Willard Marriott Library. The library has completed digitization Marriott Library, 801-585-9391, walter.jones@utah.edu --Dale Snyder, External Relations Director, J

  8. Predicting Library of Congress Classifications From Library of Congress Subject Headings

    E-Print Network [OSTI]

    Frank, Eibe

    Predicting Library of Congress Classifications From Library of Congress Subject Headings Eibe Frank This paper addresses the problem of automatically assigning a Library of Congress Classification (LCC and training data from a large library catalog to learn a model which maps from sets of LCSH to classifications

  9. Independent Component Analysis For EEG Source Localization In Realistic Head Models

    E-Print Network [OSTI]

    Utah, University of

    1 Independent Component Analysis For EEG Source Localization In Realistic Head Models Leonid Zhukov Abstract-- A pervasive problem in neuroscience is determining which regions of the brain are active, given within the brain from electroencephalo- graphic (EEG) recordings is an ill-posed problem. Specifi- cally

  10. Independent Component Analysis For EEG Source Localization In Realistic Head Models

    E-Print Network [OSTI]

    Utah, University of

    1 Independent Component Analysis For EEG Source Localization In Realistic Head Models Leonid Zhukov Abstract--- A pervasive problem in neuroscience is determining which regions of the brain are active, given within the brain from electroencephalo graphic (EEG) recordings is an illposed problem. Specifi cally

  11. Digital library as a controversy Running head: DIGITAL LIBRARY AS A CONTROVERSY

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Digital library as a controversy Running head: DIGITAL LIBRARY AS A CONTROVERSY Digital library nouvelle 1 hal-00718385,version1-16Jul2012 Author manuscript, published in "Digital library as a controversy: Gallica vs Google, Dubrovnik : Croatia (2009)" #12;Digital library as a controversy Abstract

  12. Late-to Post-Cretaceous Inversion of the British Isles Tectonic Stylolites at Flamborough Head

    E-Print Network [OSTI]

    Guo, Zaoyang

    not much is known about younger inversion events in the UK. Industrial: A lot of the oil and gas traps. Geology 36(11), 839-842. Koehn, D., Renard, F., Toussaint, R., Passchier, C.W. (2007) Growth of stylolite at Flamborough Head, U.K. Journal of Structural Geology 16, 97-107. Application procedure and deadlines

  13. Running head: Diagenesis of Beacon Sandstone Diagenetic history of Triassic sandstone from the Beacon Supergroup in

    E-Print Network [OSTI]

    Boyer, Edmond

    1 Running head: Diagenesis of Beacon Sandstone Diagenetic history of Triassic sandstone from of shallow burial diagenesis, contact diagenesis (temperatures of 200-300C), and post-contact diagenesis, on the basis of petrographic and geochemical analyses. Shallow burial diagenesis is characterised by minor

  14. Student Award Competition Finite Element EEG and MEG Simulations for Realistic Head Models

    E-Print Network [OSTI]

    Zhukov, Leonid

    than would be possible using linear elements alone. [1] D.S. Burnett. Finite Element Analysis: FromStudent Award Competition Finite Element EEG and MEG Simulations for Realistic Head Models be approximated by a technique such as the finite element method [1]. Most applications of the finite element

  15. Running Head: Patterns of Sequence Evolution Patterns of Sequence Evolution and Implications for

    E-Print Network [OSTI]

    Olmstead, Richard

    Running Head: Patterns of Sequence Evolution Patterns of Sequence Evolution and Implications. Yen. 1998. Patterns of sequence evolution and implications for parsimony analysis of chloroplast DNA. Pp. 164-187 In: Molecular Systematics of Plants II: DNA sequencing (eds, P. S. Soltis, D. E. Soltis

  16. JN-00488-2005.R2 Running Head: SOMATOTOPY AND MOTOR IMAGERY

    E-Print Network [OSTI]

    Zacks, Jeffrey M.

    JN-00488-2005.R2 Running Head: SOMATOTOPY AND MOTOR IMAGERY Lateral somatotopic organization during-7588 #12;JN-00488-2005.R2 Somatotopy and motor imagery 2 Abstract Motor imagery is a complex cognitive of the physical movements being imagined. Likewise, motor preparation may or may not involve computations

  17. August 18, 2009 MEMO TO: Vice Presidents, Deans, Directors, Chairs and Administrative Heads

    E-Print Network [OSTI]

    Su, Xiao

    Heads FROM: Jon Whitmore President SUBJECT: Presidential Directive 2009-04 Executive Order No. 1043 Student Conduct Procedures Supersedes: Presidential Directive 2007-01 In accordance with California State or some proceedings. San Jos State University does not permit attorneys to be present in any proceeding

  18. Dumbarton Express Line DB heading to Stanford Oval. AC Transit Line U on Palm Drive.

    E-Print Network [OSTI]

    Dumbarton Express Line DB heading to Stanford Oval. AC Transit Line U on Palm Drive. Photo: Karl Nielsen Photo: Dong Wang Schedules: AC Transit Line U Dumbarton Express Line DB Connections with BART Transit Line U Line U provides express service between Stanford and the Fremont BART station. Other East

  19. Prediction Error and Event Boundaries 1 Running Head: PREDICTION ERROR AND EVENT BOUNDARIES

    E-Print Network [OSTI]

    Zacks, Jeffrey M.

    Prediction Error and Event Boundaries 1 Running Head: PREDICTION ERROR AND EVENT BOUNDARIES A computational model of event segmentation from perceptual prediction. Jeremy R. Reynolds, Jeffrey M. Zacks, and Todd S. Braver Washington University Manuscript #12;Prediction Error and Event Boundaries 2 People tend

  20. Highway 280 North or South Take the Sand Hill Road exit, head east

    E-Print Network [OSTI]

    Ford, James

    Highway 280 North or South Take the Sand Hill Road exit, head east Turn right on Stock Farm for "all" below From Bayshore US Highway 101 NorthFrom Bayshore US Highway 101 North or South Take Turn left on Stock Farm Road LKSC ParkingTurn left on Stock Farm Road Make the next lefthand turn

  1. Multiple systems or task complexity 1 Running head: Multiple systems or task complexity

    E-Print Network [OSTI]

    Stoiciu, Mihai

    Multiple systems or task complexity 1 Running head: Multiple systems or task complexity Procedural memory effects in categorization: evidence for multiple systems or task complexity? Safa R. Zaki and Dave College Williamstown, MA 10267 413-597-4594 Email: szaki@williams.edu #12;Multiple systems or task

  2. A new design criterion based on pressure testing of torispherical heads

    SciTech Connect (OSTI)

    Kalnins, A. [Lehigh Univ., Bethlehem, PA (United States). Dept. of Mechanical Engineering and Mechanics; Rana, M.D. [Praxair, Inc., Tonawanda, NY (United States). Research and Development Dept.

    1996-08-01T23:59:59.000Z

    Two vessels with torispherical heads were pressurized to destruction at the Praxair Tonawanda facility on September 12--13, 1994. The objective was to determine pressures at which observable or measurable indications of failure could be detected. Plastic limit pressures for the two heads were calculated at 190 and 240 psi, respectively. For Vessel 1, the only observable action was a slow formation of some waviness of the knuckle profile at approximately 600 psi. It lost pressure at 700 psi when a crack developed at a nozzle weld at the bottom of the shell. For Vessel 2, no indication of any sign of failure was observed until it burst at a pressure of 1,080 psi by a ductile fracture along the longitudinal weld of the shell. The main conclusion is that there is a problem in the application of the double elastic slope collapse criterion to torispherical heads. It was determined that when using this criterion a collapse pressure signaling excessive deformation cannot be determined with any certainty. Furthermore, the test data do not show anything at any of the calculated collapse pressures that suggests excessive deformation. Thus, the collapse pressures for torispherical heads cannot be confirmed by test. This leads to the inconsistency that if the collapse load is divided by a safety factor, say 1.5, to obtain an allowable pressure, the actual safety margin of the design is not known and may not be 1.5. For a material with sufficient ductility, the use of an estimated burst pressure appears preferable. A design criterion based on the membrane stress at the crown of a torispherical head reaching the ultimate tensile strength is proposed, which is simple, can be supported by theoretical arguments, and is shown to be conservative by current test results as well as by those of two previous test programs.

  3. Western Pond Turtle Head-starting and Reintroduction; 2003-2004 Annual Report.

    SciTech Connect (OSTI)

    Van Leuven, Susan; Allen, Harriet; Slavin, Kate (Washington Department of Fish and Wildlife, Wildlife Management Program, Olympia, WA)

    2004-09-01T23:59:59.000Z

    This report covers the results of the western pond turtle head-starting and reintroduction project for the period of October 2003-September 2004. Wild hatchling western pond turtles from the Columbia River Gorge were reared at the Woodland Park and Oregon Zoos in 2003 and 2004 as part of the recovery effort for this Washington State endangered species. The objective of the program is to reduce losses to introduced predators like bullfrogs and largemouth bass by raising the hatchlings to a size where they are too large to be eaten by most of these predators. Sixty-nine turtles were over-wintered at the Woodland Park Zoo and 69 at the Oregon Zoo. Of these, 136 head-started juvenile turtles were released at three sites in the Columbia Gorge in 2004. Two were held back to attain more growth in captivity. Thirty-four were released at the Klickitat ponds, 19 at the Klickitat lake, 21 at the Skamania site, and 62 at Pierce National Wildlife Refuge (NWR). This brought the total number of head-start turtles released since 1991 to 246 for the Klickitat ponds, 114 for the Klickitat lake, 167 for the Skamania pond complex, and 250 at Pierce NWR. In 2004, 32 females from the two Columbia Gorge populations were equipped with transmitters and monitored for nesting activity. Twenty-one of the females nested and produced 85 hatchlings. The hatchlings were collected in September and October and transported to the Woodland Park and Oregon zoos for rearing in the head-start program. Data collection for a four-year telemetry study of survival and habitat use by juvenile western pond turtles at Pierce NWR concluded in 2004. Radio transmitters on study animals were replaced as needed until all replacements were in service; afterward, the turtles were monitored until their transmitters failed. The corps of study turtles ranged from 39 in August 2003 to 2 turtles at the end of August 2004. These turtles showed the same seasonal pattern of movements between summer water and upland winter habitats observed in previous years. During the 2004 field season trapping effort, 345 western pond turtles were captured in the Columbia Gorge, including 297 previously head-started turtles. These recaptures, together with confirmed nesting by head-start females and visual resightings, indicate the program is succeeding in boosting juvenile recruitment to increase the populations. Records were also collected on 224 individual painted turtles captured in 2004 during trapping efforts at Pierce NWR, to gather baseline information on this native population. Bonneville Power Administration (BPA) funded approximately 60% of program activities in the Columbia River Gorge from October 2003 through September 2004.

  4. Western Pond Turtle Head-starting and Reintroduction, 2005-2006 Annual Report.

    SciTech Connect (OSTI)

    Van Leuven, Susan; Allen, Harriet; Slavens, Kate (Washington Department of Fish and Wildlife, Wildlife Management Program, Olympia, WA)

    2006-11-01T23:59:59.000Z

    This report covers the results of the western pond turtle head-starting and reintroduction project for the period of October 2005-September 2006. Wild hatchling western pond turtles from the Columbia River Gorge were reared at the Woodland Park and Oregon zoos in 2005 and 2006 as part of the recovery effort for this Washington State endangered species. The objective of the program is to reduce losses to introduced predators like bullfrogs and largemouth bass by raising the hatchlings to a size where they are too large to be eaten by most of these predators. Twenty-six turtles were placed at the Woodland Park Zoo and 62 at the Oregon Zoo in fall 2005. These turtles joined two that were held back from release in summer 2005 due to their small size. All 90 juvenile turtles were released at three sites in the Columbia Gorge in 2006. Twenty-eight juvenile turtles were released at the Klickitat ponds, 22 at the Klickitat lake, 21 at the Skamania site, and 19 at Pierce National Wildlife Refuge (NWR). This brought the total number of head-start turtles released since 1991 to 944; 285 for the Klickitat ponds, 158 for the Klickitat lake, 227 for the Skamania pond complex, and 274 at Pierce NWR. In 2006, 20 females from the Klickitat population were equipped with transmitters and monitored for nesting activity. Fifteen nests were located and protected; these produced 55 hatchlings. The hatchlings were collected in September and transported to the Oregon and Woodland Park zoos for rearing in the head-start program. One wild hatchling captured in spring 2006 was placed in the head-start program to attain more growth in captivity. During the 2006 field season trapping effort, 414 western pond turtles were captured in the Columbia Gorge, including 374 previously head-started turtles. These recaptures, together with confirmed nesting by head-start females and visual resightings, indicate the program is succeeding in boosting juvenile recruitment to increase the populations. Records were also collected on 179 individual painted turtles captured in 2006 during trapping efforts at Pierce NWR, to gather baseline information on this native population.

  5. Western Pond Turtle Head-starting and Reintroduction; 2004-2005 Annual Report.

    SciTech Connect (OSTI)

    Van Leuven, Susan; Allen, Harriet; Slavin, Kate (Washington Department of Fish and Wildlife, Wildlife Management Program, Olympia, WA)

    2005-09-01T23:59:59.000Z

    This report covers the results of the western pond turtle head-starting and reintroduction project for the period of October 2004-September 2005. Wild hatchling western pond turtles from the Columbia River Gorge were reared at the Woodland Park and Oregon Zoos in 2004 and 2005 as part of the recovery effort for this Washington State endangered species. The objective of the program is to reduce losses to introduced predators like bullfrogs and largemouth bass by raising the hatchlings to a size where they are too large to be eaten by most of these predators. Thirty-five turtles were placed at the Woodland Park Zoo and 53 at the Oregon Zoo. Of these, 77 head-started juvenile turtles were released at three sites in the Columbia Gorge in 2005. Four were held back to attain more growth in captivity. Eleven were released at the Klickitat ponds, 22 at the Klickitat lake, 39 at the Skamania site, and 5 at Pierce National Wildlife Refuge (NWR). This brought the total number of head-start turtles released since 1991 to 257 for the Klickitat ponds, 136 for the Klickitat lake, 206 for the Skamania pond complex, and 255 at Pierce NWR. In 2005, 34 females from the two Columbia Gorge populations were equipped with transmitters and monitored for nesting activity. Twenty-four nests were located and protected; these produced 90 hatchlings. The hatchlings were collected in September and transported to the Oregon and Woodland Park zoos for rearing in the head-start program. During the 2005 field season trapping effort, 486 western pond turtles were captured in the Columbia Gorge, including 430 previously head-started turtles. These recaptures, together with confirmed nesting by head-start females and visual resightings, indicate the program is succeeding in boosting juvenile recruitment to increase the populations. Records were also collected on 216 individual painted turtles captured in 2005 during trapping efforts at Pierce NWR, to gather baseline information on this native population. Bonneville Power Administration (BPA) funded approximately 75% of program activities in the Columbia River Gorge from October 2004 through September 2005.

  6. Calibration of an Active Binocular Head ShengWen Shih y , YiPing Hung z , and WeiSong Lin y

    E-Print Network [OSTI]

    Chen, Sheng-Wei

    1 Calibration of an Active Binocular Head Sheng­Wen Shih y , Yi­Ping Hung z , and Wei­Song Lin y y binocular head, the IIS head, can be easily calibrated with very high accuracy. Our calibration method can­stage calibration process, there are three major contributions in this paper. First, we propose a MFL (Motorized

  7. Chemical effects head-loss research in support of generic safety issue 191.

    SciTech Connect (OSTI)

    Park, J. H.; Kasza, K.; Fisher, B.; Oras, J.; Natesan, K.; Shack, W. J.; Nuclear Engineering Division

    2006-10-31T23:59:59.000Z

    This summary report describes studies conducted at Argonne National Laboratory on the potential for chemical effects on head loss across sump screens. Three different buffering solutions were used for these tests: trisodium phosphate (TSP), sodium hydroxide, and sodium tetraborate. These pH control agents used following a LOCA at a nuclear power plant show various degrees of interaction with the insulating materials Cal-Sil and NUKON. Results for Cal-Sil dissolution tests in TSP solutions, settling rate tests of calcium phosphate precipitates, and benchmark tests in chemically inactive environments are also presented. The dissolution tests were intended to identify important environmental variables governing both calcium dissolution and subsequent calcium phosphate formation over a range of simulated sump pool conditions. The results from the dissolution testing were used to inform both the head loss and settling test series. The objective of the head loss tests was to assess the head loss produced by debris beds created by Cal-Sil, fibrous debris, and calcium phosphate precipitates. The effects of both the relative arrival time of the precipitates and insulation debris and the calcium phosphate formation process were specifically evaluated. The debris loadings, test loop flow rates, and test temperature were chosen to be reasonably representative of those expected in plants with updated sump screen configurations, although the approach velocity of 0.1 ft/s used for most of the tests is 3-10 times that expected in plants with large screens . Other variables were selected with the intent to reasonably bound the head loss variability due to arrival time and calcium phosphate formation uncertainty. Settling tests were conducted to measure the settling rates of calcium phosphate precipitates (formed by adding dissolved Ca to boric acid and TSP solutions) in water columns having no bulk directional flow. For PWRs where NaOH and sodium tetraborate are used to control sump pH and fiberglass insulation is prevalent, relatively high concentrations of soluble aluminum can be expected. Tests in which the dissolved aluminum (Al) resulted from aluminum nitrate additions were used to investigate potential chemical effects that may lead to high head loss. Dissolved Al concentrations of 100 ppm were shown to lead to large pressure drops for the screen area to sump volume ratio and fiber debris bed studied. No chemical effects on head loss were observed in sodium tetraborate buffered solutions even for environments with high ratios of submerged Al area to sump volume. However, in tests with much higher concentrations of dissolved Al than expected in plants, large pressure drops did occur. Interaction with NUKON/Cal-Sil debris mixtures produced much lower head losses than observed in corresponding tests with TSP, although tests were not performed over the full range of Cal-Sil that might be of interest.

  8. Enhancement of Corium Coolability with CRGTs in the Lower Head of a BWR

    SciTech Connect (OSTI)

    Sehgal, Bal Raj; Jasiulevicius, Audrius; Konovalikhin, Maxim J. [Nuclear Power Safety Division, Royal Institute of Technology, Stockholm Drottning Kristinas vaeg 33A, SE-10044, Stockholm (Sweden)

    2004-07-01T23:59:59.000Z

    A series of experiments were preformed in the POMECO (Porous Media Coolability) and the COMECO (Corium Melt Coolability) test facilities at the Nuclear Power Safety Division of the Royal Institute of Technology, Stockholm. During the experiments particulate debris beds and molten pools were cooled by establishing a water layer above them. The main aim of the experiments was to investigate the additional coolability capacity offered by the Control Rod Guide Tubes (CRGTs) in the lower head of the Reactor Pressure Vessel (RPV) of a Boiling Water Reactor (BWR). Each CRGT has a substantial heat transfer area and there is large number of these tubes in the BWR lower head. The coolant is supplied to the RPV via the CRGTs during the normal reactor operation and this coolant flow could be maintained during a severe accident. The primary objective of the experimental program was to obtain data on the heat removal capacity, offered by a CRGT. This paper presents results of the experiments. (authors)

  9. Head-on collision of ion-acoustic solitary waves in multicomponent plasmas with positrons

    SciTech Connect (OSTI)

    El-Shamy, E. F.; Sabry, R. [Department of Physics, Theoretical Physics Group, Faculty of Science, Mansoura University, Damietta-Branch, New Damietta 34517, Damietta (Egypt); Moslem, W. M. [Department of Physics, Faculty of Science, Port Said University, Port Said (Egypt); Shukla, P. K. [Institut fuer Theoretische Physik IV, Fakultaet fuer Physik und Astronomie, Ruhr-Universitaet Bochum, D-44780 Bochum (Germany)

    2010-08-15T23:59:59.000Z

    The head-on collision between two ion-acoustic solitary waves in an unmagnetized multicomponent plasma consisting of hot ions, hot positrons, and two-electron temperature distributions is investigated using the extended Poincare-Lighthill-Kuo method. The Kortwege-de Vries equations and the analytical phase shifts after the head-on collision of two solitary waves in this multicomponent plasma are obtained. The effects of two different types of isothermal electrons, the ratio of the hot ion temperature to the effective temperature, the ratio of the effective temperature to the positron temperature, the ratio of the number density of positrons to that of electrons species, and the physical processes (either isothermal or adiabatic) on the phase shifts are studied. It is found that these parameters can significantly influence the phase shifts of the solitons. The relevance of this investigation to space and laboratory plasmas is pointed out.

  10. Observation of the 'head-tail' effect in nuclear recoils of low-energy neutrons

    E-Print Network [OSTI]

    D. Dujmic; H. Tomita; M. Lewandowska; S. Ahlen; P. Fisher; S. Henderson; A. Kaboth; G. Kohse; R. Lanza; J. Monroe; A. Roccaro; G. Sciolla; N. Skvorodnev; R. Vanderspek; H. Wellenstein; R. Yamamoto

    2007-10-09T23:59:59.000Z

    Directional detection of dark matter can provide unambiguous observation of dark matter interactions even in the presence of background. This article presents an experimental method to measure the direction tag ("head-tail") of the dark matter wind by detecting the scintillation light created by the elastic nuclear recoils in the scattering of dark matter particles with the detector material. The technique is demonstrated by tagging the direction of the nuclear recoils created in the scattering of low-energy neutrons with CF4 in a low-pressure time-projection chamber that is developed by the DMTPC collaboration. The measurement of the decreasing ionization rate along the recoil trajectory provides the direction tag of the incoming neutrons, and proves that the "head-tail" effect can be observed.

  11. Head-end process for the reprocessing of HTGR spent fuel

    SciTech Connect (OSTI)

    Chen, J.; Wen, M. [Institute of Nuclear and New Energy Technology, Tsinghua University, Bejing 10084 (China)

    2013-07-01T23:59:59.000Z

    The reprocessing of HTGR spent fuels is in favor of the sustainable development of nuclear energy to realize the maximal use of nuclear resource and the minimum disposal of nuclear waste. The head-end of HTGR spent fuels reprocessing is different from that of the LWR spent fuels reprocessing because of the difference of spent fuel structure. The dismantling of the graphite spent fuel element and the highly effective dissolution of fuel kernel is the most difficult process in the head end of the reprocessing. Recently, some work on the head-end has been done in China. First, the electrochemical method with nitrate salt as electrolyte was studied to disintegrate the graphite matrix from HTGR fuel elements and release the coated fuel particles, to provide an option for the head-end technology of reprocessing. The results show that the graphite matrix can be effectively separated from the coated particle without any damage to the SiC layer. Secondly, the microwave-assisted heating was applied to dissolve the UO{sub 2} kernel from the crashed coated fuel particles. The ceramic UO{sub 2} as the solute has a good ability to absorb the microwave energy. The results of UO{sub 2} kernel dissolution from crushed coated particles by microwave heating show that the total dissolution percentage of UO{sub 2} is more than 99.99% after 3 times cross-flow dissolution with the following parameters: 8 mol/L HNO{sub 3}, temperature 100 Celsius degrees, initial ratio of solid to liquid 1.2 g/ml. (authors)

  12. Head-on beam-beam tune shifts with high brightness beams in the LHC

    E-Print Network [OSTI]

    Alemany, R; Calaga, R; Cornelis, K; Fitterer, M; Giachino, R; Herr, W; McPherson, A; Miyamoto, R; Papotti, G; Pieloni, T; Redaelli, S; Roncarolo, F; Schaumann, M; Suykerbuyk, R; Trad, G; Paret, S

    2011-01-01T23:59:59.000Z

    In this experiment (fills 1765, 1766) we have collided bunches with highest brightness, i.e. small emittances and high intensities, to explore the achievable beam-beam tune shift for head-on collisions. Different parameters and filling schemes have been used for this experiment and tune shifts above 0.015 have been achieved in single collisions and above 0.030 for two collision points.

  13. Determination of selected trace elements in human head hair by neutron activation analysis

    E-Print Network [OSTI]

    Courson, Leonard Austin

    1981-01-01T23:59:59.000Z

    barber shops and beauty salons in the Bryan-College Station Met- ropolitan Area. The locations of the prospective collection sites were selected at random from the local telephone directory. Though some of these sites did not elect to participate... for the degree of MASTER OF SCIENCE December 1981 Major Subject: Nuclear Engineering DETERMINATION OF SELECTEO TRACE ELEMENTS IN HUMAN HEAD HAIR BY NEUTRON ACTIVATION ANALYSIS A Thesis by LEONARD AUSTIN COURSON Approved as to style and content by Chai r...

  14. Assessing the Transient Flow Behavior in Falling-head Permeameter Tests

    E-Print Network [OSTI]

    Cavdar, Sevgi

    2013-04-29T23:59:59.000Z

    of MASTER OF SCIENCE Approved by: Chair of Committee, Hongbin Zhan Committee Members, David Sparks Marcelo Sanchez Benchun Duan Head of Department, John R. Giardino May 2013 Major Subject: Geology Copyright 2013 Sevgi Cavdar ii... support throughout the final weeks and procedures. I am indebted to my committee members: to Dr. David Sparks for his honesty and his guidance through the programing part, and to Dr. Benchun Duan and Dr. Marcelo Sanchez for accepting to serve in my...

  15. Lattice design for head-on beam-beam compensation at RHIC

    SciTech Connect (OSTI)

    Montag, C.

    2011-03-28T23:59:59.000Z

    Electron lenses for head-on beam-beam compensation will be installed in IP 10 at RHIC. Compensation of the beam-beam effect experienced at IP 8 requires betatron phase advances of {Delta}{psi} = k {center_dot} {pi} between the proton-proton interaction point at IP 8, and the electron lens at IP 10. This paper describes the lattice solutions for both the BLUE and the YELLOW ring to achieve this goal.

  16. Redelegation/Designation Order No. 00-022.06A to Anthony H. Montoya as head

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection RadiationRecord-SettingHead of Contracting Activity (HCA) for theof

  17. Creep failure of a reactor pressure vessel lower head under severe accident conditions

    SciTech Connect (OSTI)

    Pilch, M.M.; Ludwigsen, J.S.; Chu, T.Y. [Sandia National Labs., Albuquerque, NM (United States); Rashid, Y.R. [Anatech, San Diego, CA (United States)

    1998-08-01T23:59:59.000Z

    A severe accident in a nuclear power plant could result in the relocation of large quantities of molten core material onto the lower head of he reactor pressure vessel (RPV). In the absence of inherent cooling mechanisms, failure of the RPV ultimately becomes possible under the combined effects of system pressure and the thermal heat-up of the lower head. Sandia National Laboratories has performed seven experiments at 1:5th scale simulating creep failure of a RPV lower head. This paper describes a modeling program that complements the experimental program. Analyses have been performed using the general-purpose finite-element code ABAQUS-5.6. In order to make ABAQUS solve the specific problem at hand, a material constitutive model that utilizes temperature dependent properties has been developed and attached to ABAQUS-executable through its UMAT utility. Analyses of the LHF-1 experiment predict instability-type failure. Predicted strains are delayed relative to the observed strain histories. Parametric variations on either the yield stress, creep rate, or both (within the range of material property data) can bring predictions into agreement with experiment. The analysis indicates that it is necessary to conduct material property tests on the actual material used in the experimental program. The constitutive model employed in the present analyses is the subject of a separate publication.

  18. A SMALL PORTABLE DETECTOR HEAD USING MIS-CONTACTED CdTe FOR X-RAY SPECTROMETRY

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    339 A SMALL PORTABLE DETECTOR HEAD USING MIS-CONTACTED CdTe FOR X-RAY SPECTROMETRY P. EICHINGER and the implications of this material for the spectroscopy of gamma rays and X-rays. Instead an arrangement

  19. Design, fabrication, and characterization of a low-cost flexural bearing based 3D printing tool head

    E-Print Network [OSTI]

    Ramirez, Aaron Eduardo

    2010-01-01T23:59:59.000Z

    This thesis discusses the design, characterization and optimization of a low-cost additive rapid-prototyping tool head for a technology known as Fused Filament Fabrication for use in an educational curriculum. Building a ...

  20. Proteome Profiling for Assessing Diversity: Analysis of Individual Heads of Drosophila melanogaster Using LC-Ion Mobility-MS

    E-Print Network [OSTI]

    Clemmer, David E.

    Proteome Profiling for Assessing Diversity: Analysis of Individual Heads of Drosophila melanogaster dimensions of condensed-phase separations with mass spec- trometry (MS).4 In this approach, mass-to-charge (m-speed, gas-phase sep

  1. Effects of head-up tilt on mean arterial pressure, heart rate, and regional cardiac output distribution in aging rats

    E-Print Network [OSTI]

    Ramsey, Michael Wiechmann

    2006-04-12T23:59:59.000Z

    Many senescent individuals demonstrate an inability to regulate mean arterial pressure (MAP) in response to standing or head-up tilt; however, whether this aging effect is the result of depressed cardiac function or an ...

  2. HEADING FRONTMATTER

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5. Hess, J.R.; Wright, C.T.; and Kenney, K.L. (2007). Cellulosic Biomass Feedstocks and Logistics for Ethanol Production. Biofuels, Bioprod. Biorefin., 1(3),...

  3. HEADING FRONTMATTER

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    JAMES E. FRANCFORT Education and Training Idaho State University, Pocatello, Idaho, USA, M S., Business Administration 1991 Idaho State University, Pocatello, Idaho, USA, B.S.,...

  4. Heading 1

    Energy Savers [EERE]

    willingly give and accept constructive feedback and coaching. On-going Dialogue I have good interpersonal skills. I am a good listener. I seek to find out information through...

  5. HEADING FRONTMATTER

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    logistics for biomass energy conversion, environmental impacts of in situ and ex situ oil shale energy development, and watershed resource management and energy issues; provides...

  6. HEADING FRONTMATTER

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Patents Files; R.D. Boardman, R.A. Carrington; "Method and Apparatus for Oil Shale Pollutant SorptionNOx Reburning, Multi-pollutant Control," June 10, 2008. 2. U.S....

  7. Heading 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2011 Technical Evaluation Study Project No. 23843 Integration of HTGRs to an Ex Situ Oil Shale Retort Operation, Economic Analysis 08022011 Form 412.09 (Rev. 10) Idaho National...

  8. Heading 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Technical Evaluation Study Project No. 23843 Integration of HTGRs with an In Situ Oil Shale Operation 05162011 2 Form 412.09 (Rev. 10) Idaho National Laboratory INTEGRATION...

  9. HEADING FRONTMATTER

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dr. Wood is currently working with the Department of Energy's Naval Petroleum and Oil Shale Reserves Office to stand up the Western Energy Corridor Initiative, and he is also...

  10. Heading 1

    Broader source: Energy.gov (indexed) [DOE]

    for Mentor May 2014 ONE PROGRAM BRINGING TOGETHER ALL DOE COMMUNITIES OF PRACTICE O O f f f f i i c c e e o o f f L L e e a a r r n n i i n n g g & & W W o o r r k k f f o o r r c...

  11. Heading 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonicbet When yourecoveryG -Hazmat work opens up

  12. Heading 1

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy ChinaofSchaefer To:Department of Energy Completing theWhiz! |Nearly sixDepartment

  13. Heading 1

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy ChinaofSchaefer To:Department of Energy Completing theWhiz! |Nearly sixDepartmentfor

  14. An on-line replanning method for head and neck adaptive radiotherapy

    SciTech Connect (OSTI)

    Ahunbay, Ergun E.; Peng, Cheng; Godley, Andrew; Schultz, Christopher; Li, X. Allen [Department of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226 (United States)

    2009-10-15T23:59:59.000Z

    Daily setup for head and neck (HN) radiotherapy (RT) can vary randomly due to neck rotation and anatomy change. These differences cannot be totally corrected by the current practice of image guided RT with translational repositioning. The authors present a novel rapid correction scheme that can be used on-line to correct both interfractional setup variation and anatomy change for HN RT. The scheme consists of two major steps: (1) Segment aperture morphing (SAM) and (2) segment weight optimization (SWO). SAM is accomplished by applying the spatial relationship between the apertures and the contours of the planning target and organs at risk (OARs) to the new target and OAR contours. The new target contours are transferred from planning target contours to the CT of the day by means of deformable registration (MIMVISTA). The dose distribution for each new aperture was generated using a planning system with a fast dose engine and hardware and was input into a newly developed SWO package using fast sequential quadratic programming. The entire scheme was tested based on the daily CT images acquired for representative HN IMRT cases treated with a linac and CT-on-Rails combo. It was found that the target coverage and/or OAR sparing was degraded based on the CT of the day with the current standard repositioning from rigid registration. This degradation can be corrected by the SAM/SWO scheme. The target coverage and OAR sparing for the SAM/SWO plans were found to be equivalent to the original plan. The SAM/SWO process took 5-8 min for the head and neck cases studied. The proposed aperture morphing with weight optimization is an effective on-line approach for correcting interfractional patient setup and anatomic changes for head and neck cancer radiotherapy.

  15. Tobacco Smoking During Radiation Therapy for Head-and-Neck Cancer Is Associated With Unfavorable Outcome

    SciTech Connect (OSTI)

    Chen, Allen M., E-mail: allen.chen@ucdmc.ucdavis.ed [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Chen, Leon M.; Vaughan, Andrew; Sreeraman, Radhika [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Farwell, D. Gregory; Luu, Quang [Department of Otolaryngology-Head and Neck Surgery, University of California Davis Cancer Center, Sacramento, CA (United States); Lau, Derick H. [Department of Medical Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Stuart, Kerri; Purdy, James A.; Vijayakumar, Srinivasan [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)

    2011-02-01T23:59:59.000Z

    Purpose: To evaluate the effect of continued cigarette smoking among patients undergoing radiation therapy for head-and-neck cancer by comparing the clinical outcomes among active smokers and quitters. Methods and Materials: A review of medical records identified 101 patients with newly diagnosed squamous cell carcinoma of the head and neck who continued to smoke during radiation therapy. Each active smoker was matched to a control patient who had quit smoking before initiation of radiation therapy. Matching was based on tobacco history (pack-years), primary site, age, sex, Karnofsky Performance Status, disease stage, radiation dose, chemotherapy use, year of treatment, and whether surgical resection was performed. Outcomes were compared by use of Kaplan-Meier analysis. Normal tissue effects were graded according to the Radiation Therapy Oncology Group/European Organization for the Treatment of Cancer toxicity criteria. Results: With a median follow-up of 49 months, active smokers had significantly inferior 5-year overall survival (23% vs. 55%), locoregional control (58% vs. 69%), and disease-free survival (42% vs. 65%) compared with the former smokers who had quit before radiation therapy (p < 0.05 for all). These differences remained statistically significant when patients treated by postoperative or definitive radiation therapy were analyzed separately. The incidence of Grade 3 or greater late complications was also significantly increased among active smokers compared with former smokers (49% vs. 31%, p = 0.01). Conclusions: Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcomes. Further studies analyzing the biologic and molecular reasons underlying these differences are planned.

  16. Coleridges Attitude Toward Various Subjects as Shown in His Biographia Epistolaris

    E-Print Network [OSTI]

    Steven, Effie Louise

    1911-01-01T23:59:59.000Z

    sinking." My medical attendant says that it is irregular gout, with nephritic symptoms. Gout, in a young man of twenty-nine 11 Swoolen knees, and knotty fingers, a loathing stomach, and a dizzy head. Trust me, friend, I am at times an object of moral... on my neck and shoulders; these, by a violent rheum atic fever; this, by a distressing and tedious hydroole; and, since then, by irregular gout, which promises at this moment to ripen into a legitimate fit. 111. To Thomas Wedgwood. Oct. 20, 1802...

  17. The Shapiro Conjecture: Prompt or Delayed Collapse in the head-on collision of neutron stars?

    E-Print Network [OSTI]

    Mark Miller; Wai-Mo Suen; Malcolm Tobias

    1999-04-19T23:59:59.000Z

    We study the question of prompt vs. delayed collapse in the head-on collision of two neutron stars. We show that the prompt formation of a black hole is possible, contrary to a conjecture of Shapiro which claims that collapse is delayed until after neutrino cooling. We discuss the insight provided by Shapiro's conjecture and its limitation. An understanding of the limitation of the conjecture is provided in terms of the many time scales involved in the problem. General relativistic simulations in the Einstein theory with the full set of Einstein equations coupled to the general relativistic hydrodynamic equations are carried out in our study.

  18. Shapiro conjecture: Prompt or delayed collapse in the head-on collision of neutron stars?

    SciTech Connect (OSTI)

    Miller, Mark; Suen, Wai-Mo; Tobias, Malcolm

    2001-06-15T23:59:59.000Z

    We study the question of prompt versus delayed collapse in the head-on collision of two neutron stars. We show that the prompt formation of a black hole is possible, contrary to a conjecture of Shapiro which claims that collapse is delayed until after neutrino cooling. An understanding of the limitation of the conjecture is provided in terms of the many time scales involved in the problem. General relativistic simulations with the full set of Einstein equations coupled to the general relativistic hydrodynamic equations are carried out.

  19. The Shapiro Conjecture Prompt or Delayed Collapse in the head-on collision of neutron stars?

    E-Print Network [OSTI]

    Miller, M; Tobias, M; Miller, Mark; Suen, Wai-Mo; Tobias, Malcolm

    1999-01-01T23:59:59.000Z

    We study the question of prompt vs. delayed collapse in the head-on collision of two neutron stars. We show that the prompt formation of a black hole is possible, contrary to a conjecture of Shapiro which claims that collapse is delayed until after neutrino cooling. We discuss the insight provided by Shapiro's conjecture and its limitation. An understanding of the limitation of the conjecture is provided in terms of the many time scales involved in the problem. General relativistic simulations in the Einstein theory with the full set of Einstein equations coupled to the general relativistic hydrodynamic equations are carried out in our study.

  20. Read/write head for a magnetic tape device having grooves for reducing tape floating

    DOE Patents [OSTI]

    Aoki, Kenji (Kawasaki, JP)

    2005-08-09T23:59:59.000Z

    A read/write head for a magnetic tape includes an elongated chip assembly and a tape running surface formed in the longitudinal direction of the chip assembly. A pair of substantially spaced parallel read/write gap lines for supporting read/write elements extend longitudinally along the tape running surface of the chip assembly. Also, at least one groove is formed on the tape running surface on both sides of each of the read/write gap lines and extends substantially parallel to the read/write gap lines.

  1. Supplement 24, Part 6, Parasite-Subject Catalogue, Subject Headings: A to I

    E-Print Network [OSTI]

    Edwards, Shirley J.; Hood, Martha W.; Shaw, Judith H.; Rayburn, Jane D.; Kirby, Margie D.; Hanfman, Deborah T.; Zidar, Judith A.

    1982-01-01T23:59:59.000Z

    index-Catalogue of Medical and veterinary zoology Supplement 24, Part 6 Parasite-Subject Catalogue Subject Headings: A to I ORYX PRESS index-Catalogue of Medical and veterinary zoology Supplement 24, Part 6 Parasite-Subject Catalogue... at Encanto Phoenix, AZ 85004 ISSN 0094-4556 A?L ver C674 ou ISBN 0-89774-051-3 (Set) ISBN 0-89774-057-2 (Part 6A) PREFACE The Index-Catalogue of Medical and Veterinary Zoology is an index to the world's literature on animal parasites of animals...

  2. Head of EM Program Tours Hanford Site Facilities | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613 122Commercial602 1,397 125 QDecemberBlogFEES FOIA FEESGraphicsforHead of EM Program

  3. Effect of oxide films on hydrogen permeability of candidate Stirling heater head tube alloys

    SciTech Connect (OSTI)

    Schuon, S R; Misencik, J A

    1981-01-01T23:59:59.000Z

    High pressure hydrogen has been selected as the working fluid for the developmental automotive Stirling engine. Containment of the working fluid during operation of the engine at high temperatures and at high hydrogen gas pressures is essential for the acceptance of the Stirling engine as an alternative to the internal combustion engine. Most commercial alloys are extremely permeable to pure hydrogen at high temperatures. A program was undertaken at NASA Lewis Research Center (LeRC) to reduce hydrogen permeability in the Stirling engine heater head tubes by doping the hydrogen working fluid with CO or CO/sub 2/. Small additions of these gases were shown to form an oxide on the inside tube wall and thus reduce hydrogen permeability. A study of the effects of dopant concentration, alloy composition, and effects of surface oxides on hydrogen permeability in candidate heater head tube alloys is summarized. Results showed that hydrogen permeability was similar for iron-base alloys (N-155, A286, IN800, 19-9DL, and Nitronic 40), cobalt-base alloys (HS-188) and nickel-base alloys (IN718). In general, the permeability of the alloys decreased with increasing concentration of CO or CO/sub 2/ dopant, with increasing oxide thickness, and decreasing oxide porosity. At high levels of dopants, highly permeable liquid oxides formed on those alloys with greater than 50% Fe content. Furthermore, highly reactive minor alloying elements (Ti, Al, Nb, and La) had a strong influence on reducing hydrogen permeability.

  4. Bottom head to shell junction assembly for a boiling water nuclear reactor

    DOE Patents [OSTI]

    Fife, Alex Blair (San Jose, CA); Ballas, Gary J. (San Jose, CA)

    1998-01-01T23:59:59.000Z

    A bottom head to shell junction assembly which, in one embodiment, includes an annular forging having an integrally formed pump deck and shroud support is described. In the one embodiment, the annular forging also includes a top, cylindrical shaped end configured to be welded to one end of the pressure vessel cylindrical shell and a bottom, conical shaped end configured to be welded to the disk shaped bottom head. Reactor internal pump nozzles also are integrally formed in the annular forging. The nozzles do not include any internal or external projections. Stubs are formed in each nozzle opening to facilitate welding a pump housing to the forging. Also, an upper portion of each nozzle opening is configured to receive a portion of a diffuser coupled to a pump shaft which extends through the nozzle opening. Diffuser openings are formed in the integral pump deck to provide additional support for the pump impellers. The diffuser opening is sized so that a pump impeller can extend at least partially therethrough. The pump impeller is connected to the pump shaft which extends through the nozzle opening.

  5. Selective evaporation of focusing fluid in two-fluid hydrodynamic print head.

    SciTech Connect (OSTI)

    Keicher, David M.; Cook, Adam W.

    2014-09-01T23:59:59.000Z

    The work performed in this project has demonstrated the feasibility to use hydrodynamic focusing of two fluid steams to create a novel micro printing technology for electronics and other high performance applications. Initial efforts focused solely on selective evaporation of the sheath fluid from print stream provided insight in developing a unique print head geometry allowing excess sheath fluid to be separated from the print flow stream for recycling/reuse. Fluid flow models suggest that more than 81 percent of the sheath fluid can be removed without affecting the print stream. Further development and optimization is required to demonstrate this capability in operation. Print results using two-fluid hydrodynamic focusing yielded a 30 micrometers wide by 0.5 micrometers tall line that suggests that the cross-section of the printed feature from the print head was approximately 2 micrometers in diameter. Printing results also demonstrated that complete removal of the sheath fluid is not necessary for all material systems. The two-fluid printing technology could enable printing of insulated conductors and clad optical interconnects. Further development of this concept should be pursued.

  6. A historical prospective cohort study of carotid artery stenosis after radiotherapy for head and neck malignancies

    SciTech Connect (OSTI)

    Brown, Paul D. [Division of Radiation Oncology, Mayo Clinic, Rochester, MN (United States)]. E-mail: brown.paul@mayo.edu; Foote, Robert L. [Division of Radiation Oncology, Mayo Clinic, Rochester, MN (United States); McLaughlin, Mark P. [Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL (United States); Halyard, Michele Y. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States); Ballman, Karla V. [Division of Biostatistics, Mayo Clinic, Rochester, MN (United States); Collie, A. Craig [Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL (United States); Miller, Robert C. [Division of Radiation Oncology, Mayo Clinic, Rochester, MN (United States); Flemming, Kelly D. [Department of Neurology, Mayo Clinic, Rochester, MN (United States); Hallett, John W. [Division of Vascular Surgery, Mayo Clinic, Rochester, MN (United States)

    2005-12-01T23:59:59.000Z

    Purpose: To determine carotid artery stenosis incidence after radiotherapy for head-and-neck neoplasms. Methods and Materials: This historical prospective cohort study comprised 44 head-and-neck cancer survivors who received unilateral neck radiotherapy between 1974 and 1999. They underwent bilateral carotid duplex ultrasonography to detect carotid artery stenosis. Results: The incidence of significant carotid stenosis (8 of 44 [18%]) in the irradiated neck was higher than that in the contralateral unirradiated neck (3 of 44 [7%]), although this difference was not statistically significant (p = 0.13). The rate of significant carotid stenosis events increased as the time after radiotherapy increased. The risk of ipsilateral carotid artery stenosis was higher in patients who had undergone a neck dissection vs. those who had not. Patients with significant ipsilateral stenosis also tended to be older than those without significant stenosis. No other patient or treatment variables correlated with risk of carotid artery stenosis. Conclusions: For long-term survivors after neck dissection and irradiation, especially those who are symptomatic, ultrasonographic carotid artery screening should be considered.

  7. Proceedings of the IAEA specialists` meeting on cracking in LWR RPV head penetrations

    SciTech Connect (OSTI)

    Pugh, C.E.; Raney, S.J. [comps.] [Oak Ridge National Lab., TN (United States)] [comps.; Oak Ridge National Lab., TN (United States)

    1996-07-01T23:59:59.000Z

    This report contains 17 papers that were presented in four sessions at the IAEA Specialists` meeting on Cracking in LWR RPV Head Penetrations held at ASTM Headquarters in Philadelphia on May 2-3, 1995. The papers are compiled here in the order that presentations were made in the sessions, and they relate to operational observations, inspection techniques, analytical modeling, and regulatory control. The goal of the meeting was to allow international experts to review experience in the field of ensuring adequate performance of reactor pressure vessel (RPV) heads and penetrations. The emphasis was to allow a better understanding of RPV material behavior, to provide guidance supporting reliability and adequate performance, and to assist in defining directions for further investigations. The international nature of the meeting is illustrated by the fact that papers were presented by researchers from 10 countries. There were technical experts present form other countries who participated in discussions of the results presented. This present document incorporates the final version of the papers as received from the authors. The final chapter includes conclusions and recommendations. Individual papers have been cataloged separately.

  8. Margin on Gross Tumor Volume and Risk of Local Recurrence in Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Caudell, Jimmy J.; Meredith, Ruby F.; Spencer, Sharon A.; Keene, Kimberley S.; Dobelbower, M. Christian [Department of Radiation Oncology, University of Alabama-Birmingham, Birmingham, AL (United States); Bonner, James A., E-mail: jabonner@uabmc.ed [Department of Radiation Oncology, University of Alabama-Birmingham, Birmingham, AL (United States)

    2010-01-15T23:59:59.000Z

    Purpose: To determine whether the method or extent of construction of the high-dose clinical target volume (CTV) and high-dose planning target volume (PTV) in intensity-modulated radiation therapy (IMRT) for head-and-neck cancer are associated with an increased risk of locoregional failure. Materials and Methods: Patients with nasopharyngeal, oropharyngeal, oral cavity, hypopharyngeal, or laryngeal squamous cell carcinomas treated definitively with IMRT were included. All patients without local relapse had a minimum follow-up of 12 months. Median follow-up for all patients was 24 months. Treatment plans of 85 available patients were reviewed, and the gross tumor volume (GTV) to PTV expansion method was estimated. Results: The GTVs were expanded volumetrically in 71 of 85 patients, by a median of 15 mm (range, 4-25 mm). An anatomic component to the expansion of GTV was used in 14 of 85 patients. Eighteen patients failed locoregionally, for an actuarial locoregional control rate of 77.2% at 2 years. There was no significant difference in locoregional control between patients with GTVs expanded volumetrically vs. those with a component of anatomic expansion. In patients with GTVs expanded volumetrically, no increase in risk of local failure was seen in patients with a total GTV expansion of <=15 mm. Conclusion: In this retrospective study, there was not an increased risk of local failure using smaller margins or expanding GTVs volumetrically when treating head-and-neck cancer patients definitively with IMRT.

  9. Evaluation of horizonal resistance to head smut Sporisorium reilianum (Kuhn) Langdon & Fullerton in Sorghum bicolor (L.) Moench

    E-Print Network [OSTI]

    Palma Carias, Alejandro

    1993-01-01T23:59:59.000Z

    inoculation in two A/B inbred lines known for their different levels of resistance in different genetic backgrounds at the Texas A&M Research Farm in College Station during the Summer of 1992 33 Means % susceptible reactions of F 1 hybrids derived from.... . . . . 2. Overall mean resistance reactions to head smut in overall F I hybrid combinations (13 hybrids each) with 4 A/B and 10 restorer lines with different genetic backgrounds for resistance / susceptibility to head smut using hypodermic syringe...

  10. Predictive Modelling of Toxicity Resulting from Radiotherapy Treatments of Head and Neck Cancer

    E-Print Network [OSTI]

    Dean, Jamie A; Harrington, Kevin J; Nutting, Christopher M; Gulliford, Sarah L

    2014-01-01T23:59:59.000Z

    In radiotherapy for head and neck cancer, the radiation dose delivered to the pharyngeal mucosa (mucosal lining of the throat) is thought to be a major contributing factor to dysphagia (swallowing dysfunction), the most commonly reported severe toxicity. There is a variation in the severity of dysphagia experienced by patients. Understanding the role of the dose distribution in dysphagia would allow improvements in the radiotherapy technique to be explored. The 3D dose distributions delivered to the pharyngeal mucosa of 249 patients treated as part of clinical trials were reconstructed. Pydicom was used to extract DICOM (digital imaging and communications in medicine) data (the standard file formats for medical imaging and radiotherapy data). NumPy and SciPy were used to manipulate the data to generate 3D maps of the dose distribution delivered to the pharyngeal mucosa and calculate metrics describing the dose distribution. Multivariate predictive modelling of severe dysphagia, including descriptions of the d...

  11. A Theory of the Beam Transfer Function (BTF) with Chromaticity Induced Head-Tail Phase Shift

    E-Print Network [OSTI]

    Fartoukh, S

    2007-01-01T23:59:59.000Z

    The feasibility of chromaticity determination by measuring head-tail phase shifts has been demonstrated both in the CERN-SPS, at HERA (DESY) and at RHIC (BNL). This method, however, requires to apply sizable transverse kick to the beam which might turn to be detrimental to the LHC performance in view of the tight emittance growth budget allowed for this machine. The aim of this paper is to extend the theory to the case of a coherent beam excitation of small amplitude, in particular at a frequency equal to the beam betatron tune (Phase Locked Loop mode), with, as a result, the possibility of envisaging a chromaticity feed-back system based on this technique for the LHC.

  12. GEANT4 Application for the Simulation of the Head of a Siemens Primus Linac

    SciTech Connect (OSTI)

    Cortes-Giraldo, M. A.; Quesada, J. M.; Gallardo, M. I. [Dep. Fisica Atomica, Molecular y Nuclear, University of Sevilla. Apdo. 1065 E-41080 Sevilla (Spain)

    2010-04-26T23:59:59.000Z

    The Monte Carlo simulation of the head of a Siemens Primus Linac used at Virgen Macarena Hospital (Sevilla, Spain) has been performed using the code GEANT4, version 9.2. In this work, the main features of the application built by our group are presented. They are mainly focused in the optimization of the performance of the simulation. The geometry, including the water phantom, has been entirely wrapped by a shielding volume which discards all the particles escaping far away through its walls. With this, a factor of four in the time spent by the simulation can be saved. An interface to read and write phase-space files in IAEA format has been also developed to save CPU time in our simulations. Finally, some calculations of the dose absorption in the water phantom have been done and compared with the results given by EGSnrc and with experimental data obtained for the calibration of the machine.

  13. Head-on collisions of electrostatic solitons in multi-ion plasmas

    SciTech Connect (OSTI)

    Verheest, Frank [Sterrenkundig Observatorium, Universiteit Gent, Krijgslaan 281, B-9000 Gent (Belgium); School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4000 (South Africa); Hellberg, Manfred A. [School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4000 (South Africa); Hereman, Willy A. [Department of Applied Mathematics and Statistics, Colorado School of Mines, Golden, Colorado 80401-1887 (United States)

    2012-09-15T23:59:59.000Z

    Head-on collisions between two electrostatic solitons are dealt with by the Poincare-Lighthill-Kuo method of strained coordinates, for a plasma composed of a number of cold (positive and negative) ion species and Boltzmann electrons. The nonlinear evolution equations for both solitons and their phase shift due to the collision, resulting in time delays, are established. A Korteweg-de Vries description is the generic conclusion, except when the plasma composition is special enough to replace the quadratic by a cubic nonlinearity in the evolution equations, with concomitant repercussions on the phase shifts. Applications include different two-ion plasmas, showing positive or negative polarity solitons in the generic case. At critical composition, a combination of a positive and a negative polarity soliton is possible.

  14. Computed tomographic studies of the head in a teaching hospital and a community hospital: a comparison

    SciTech Connect (OSTI)

    McNeil, B.J.; Kirkwood, J.R.; Hanley, J.A.; Polak, J.; Wilkinson, R.; Funkenstein, H.H.

    1982-11-01T23:59:59.000Z

    This investigation compared the use of computed tomography (CT) of the head at a large primary medical-school-affiliated hospital and at a large community hospital. There were two aims: first, to study the intrinsic characteristics of the patients in an attempt to determine the protential for developing accurate discrimination algorithms; and second, to study the patterns of neurodiagnostic tests used at these facilities. The results indicated that separability of patients into normal and abnormal categories at both institutions was extremely small. In addition, there was no significant difference in the numbers or types of ancillary tests used at both institutions. Overall, these data once more confirm the difficulty of altering CT usage patterns in primary or secondary hospitals without significantly affecting the number of abnormal patients identified.

  15. The nerve supply to the major organs and tissues of the caprine head

    E-Print Network [OSTI]

    Tatum, Michael Edward

    1969-01-01T23:59:59.000Z

    've, deep brAanehes A ? CAenicuiate I"66npixen 8- . '. tAxi J 0 r pe t re) e a 1 nAe r ve C St. apedxa1 nerve D-Cnerda tyMpan. i nex"ve E- Cauda1 aurieIulax nex've P ? Digastric nexve G- Stylobyoid nexve FXgUX S 1 1 - D3 S jXXbUt XOIX 0 f tI1Q IXPPOg... ? ZggoQlet 1c bo ne 6-Maxilla H-Fncial tubelasi. ty l-N!Isnl bone J leal . Ol"b3. id. l fazed!!Ien K- incisive bane 4- Pills ' 1ne f 3. sen 1'e figure 3 - Sagittal section of the head showing dietri13ntion 0 f the ol factor/ nerve A...

  16. Head-on-collision of modulated dust acoustic waves in strongly coupled dusty plasma

    SciTech Connect (OSTI)

    El-Labany, S. K.; El-Depsy, A.; Zedan, N. A. [Department of Physics, Faculty of Science, Damietta University, P.O. 34517, New Damietta (Egypt); El-Taibany, W. F. [Department of Physics, Faculty of Science, Damietta University, P.O. 34517, New Damietta (Egypt); Department of Physics, College of Science for Girls in Abha, King Khalid University, P.O. 960, Abha (Saudi Arabia); El-Shamy, E. F. [Department of Physics, Faculty of Science, Damietta University, P.O. 34517, New Damietta (Egypt); Department of Physics, College of Science, King Khalid University, P.O. 9004, Abha (Saudi Arabia)

    2012-10-15T23:59:59.000Z

    The derivative expansion perturbation method is applied to a strongly coupled dusty plasma system consisting of negatively charged dust grains, electrons, and ions. The basic equations are reduced to a nonlinear Schroedinger type equation appropriate for describing the modulated dust acoustic (DA) waves. We have examined the modulation (in) stability and the dependence of the system physical parameters (angular frequency and group velocity) on the polarization force variation. Finally, the extended Poincare-Lighthill-Kuo technique is employed to investigate the head-on collision (HoC) between two DA dark solitons. The analytical phase shifts and the trajectories of these dark solitons after the collision are derived. The numerical illustrations show that the polarization effect has strong influence on the nature of the phase shifts and the trajectories of the two DA dark solitons after collision.

  17. Unbounded energies of debris from head-on particle collisions near black holes

    E-Print Network [OSTI]

    O. B. Zaslavskii

    2015-05-07T23:59:59.000Z

    If two particles move toward a black hole and collide near the horizon, the energy E_{c.m.} in the centre of mass can grow unbounded. This is a so-called Ba\\~nados-Silk-West (BSW) effect. One of problems creating obstacles to the possibility of its observation consists in that individual energy E of a fragment at infinity remains finite because of redshift. We show that in the case of head-on collision, debris may have unbounded energy E. An essential ingredient of this scenario is a particle moving away from a black hole in the near-horizon region. It can appear due to precedent collision that implies multiple scattering.

  18. Inter- and Intrafractional Positional Uncertainties in Pediatric Radiotherapy Patients With Brain and Head and Neck Tumors

    SciTech Connect (OSTI)

    Beltran, Chris, E-mail: chris.beltran@stjude.or [Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN (United States); Krasin, Matthew J.; Merchant, Thomas E. [Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN (United States)

    2011-03-15T23:59:59.000Z

    Purpose: To estimate radiation therapy planning margins based on inter- and intrafractional uncertainty for pediatric brain and head and neck tumor patients at different imaging frequencies. Methods: Pediatric patients with brain (n = 83) and head and neck (n = 17) tumors (median age = 7.2 years) were enrolled on an internal review board-approved localization protocol and stratified according to treatment position and use of anesthesia. Megavoltage cone-beam CT (CBCT) was performed before each treatment and after every other treatment. The pretreatment offsets were used to calculate the interfractional setup uncertainty (SU), and posttreatment offsets were used to calculate the intrafractional residual uncertainty (RU). The SU and RU are the patient-related components of the setup margin (SM), which is part of the planning target volume (PTV). SU data was used to simulate four intervention strategies using different imaging frequencies and thresholds. Results: The SM based on all patients treated on this study was 2.1 mm (SU = 0.9 mm, RU = 1.9 mm) and varied according to treatment position (supine = 1.8 mm, prone = 2.6 mm) and use of anesthesia (with = 1.7 mm, without = 2.5 mm) because of differences in the RU. The average SU for a 2-mm threshold based on no imaging, once per week imaging, initial five images, and daily imaging was 3.6, 2.1, 2.2, and 0.9 mm, respectively. Conclusion: On the basis of this study, the SM component of the PTV may be reduced to 2 mm for daily CBCT compared with 3.5 mm for weekly CBCT. Considering patients who undergo daily pretreatment CBCT, the SM is larger for those treated in the prone position or smaller for those treated under anesthesia because of differences in the RU.

  19. Protons in Head-and-Neck Cancer: Bridging the Gap of Evidence

    SciTech Connect (OSTI)

    Ramaekers, Bram L.T., E-mail: bram.ramaekers@mumc.nl [Department of Health Services Research, School for Public Health and Primary Care, Maastricht University, Maastricht (Netherlands); Department of Radiation Oncology, Maastricht University Medical Center, Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht (Netherlands); Grutters, Janneke P.C. [Department of Health Services Research, School for Public Health and Primary Care, Maastricht University, Maastricht (Netherlands)] [Department of Health Services Research, School for Public Health and Primary Care, Maastricht University, Maastricht (Netherlands); Pijls-Johannesma, Madelon; Lambin, Philippe [Department of Radiation Oncology, Maastricht University Medical Center, Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht (Netherlands)] [Department of Radiation Oncology, Maastricht University Medical Center, Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht (Netherlands); Joore, Manuela A. [Department of Health Services Research, School for Public Health and Primary Care, Maastricht University, Maastricht (Netherlands) [Department of Health Services Research, School for Public Health and Primary Care, Maastricht University, Maastricht (Netherlands); Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center, Maastricht (Netherlands); Langendijk, Johannes A. [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)] [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)

    2013-04-01T23:59:59.000Z

    Purpose: To use Normal Tissue Complication Probability (NTCP) models and comparative planning studies to explore the (cost-)effectiveness of swallowing sparing intensity modulated proton radiotherapy (IMPT) compared with swallowing sparing intensity modulated radiotherapy with photons (IMRT) in head and neck cancer (HNC). Methods and Materials: A Markov model was constructed to examine and compare the costs and quality-adjusted life years (QALYs) of the following strategies: (1) IMPT for all patients; (2) IMRT for all patients; and (3) IMPT if efficient. The assumption of equal survival for IMPT and IMRT in the base case analysis was relaxed in a sensitivity analysis. Results: Intensity modulated proton radiation therapy and IMRT for all patients yielded 6.620 and 6.520 QALYs and cost 50,989 and 41,038, respectively. Intensity modulated proton radiation therapy if efficient yielded 6.563 QALYs and cost 43,650. The incremental cost-effectiveness ratio of IMPT if efficient versus IMRT for all patients was 60,278 per QALY gained. In the sensitivity analysis, IMRT was more effective (0.967 QALYs) and less expensive (8218) and thus dominated IMPT for all patients. Conclusions: Cost-effectiveness analysis based on normal tissue complication probability models and planning studies proved feasible and informative and enables the analysis of individualized strategies. The increased effectiveness of IMPT does not seem to outweigh the higher costs for all head-and-neck cancer patients. However, when assuming equal survival among both modalities, there seems to be value in identifying those patients for whom IMPT is cost-effective.

  20. Testosterone and prolactin in two songbirds that differ in paternal care: the blue-headed vireo and the red-eyed vireo

    E-Print Network [OSTI]

    ) and prolactin (PRL). Concentrations of plasma T and PRL were compared in breeding Blue-headed Vireos (Vireo decreased during incubation, nestling, and fledgling stages. In male Blue-headed Vireos, plasma PRL stages. Plasma PRL increased in male Red-eyed Vireos at the incubation stage and remained moderately

  1. Running heading: Water retention properties of the clay in clayey soils Water retention properties of the clay in soils developed

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    1 Running heading: Water retention properties of the clay in clayey soils Water retention properties of the clay in soils developed on clayey sediments: Significance of parent material and soil of clayey subsoils horizons according to the variation of clay characteristics. The horizons studied

  2. Running Head: MORAL HAZARD, POWER AND ACCOUNTABILITY Masters of the Universe: How Power and Accountability Influence Self-Serving Decisions

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Running Head: MORAL HAZARD, POWER AND ACCOUNTABILITY Masters of the Universe: How Power Pitesa, Department of People, Organizations and Society, Grenoble Ecole de Management; Stefan Thau this article should be addressed to Marko Pitesa, Department of People, Organizations and Society, Grenoble

  3. Running heading: Bulk density of a clayey subsoil Increase in the bulk density of a Grey Clay subsoil by

    E-Print Network [OSTI]

    Boyer, Edmond

    1 Running heading: Bulk density of a clayey subsoil Increase in the bulk density of a Grey Clay of the prisms were coated by material similar in composition to the topsoil and separated from as the profile dries over summer leading to widening of cracks between prismatic peds, (2) infilling of cracks

  4. Running head: APA SIXTH EDITION GUIDELINES 1 APA Sixth Edition Guidelines for Paper Formatting in the College of Nursing Program

    E-Print Network [OSTI]

    Arizona, University of

    Running head: APA SIXTH EDITION GUIDELINES 1 APA Sixth Edition Guidelines for Paper Formatting of Arizona #12;APA SIXTH EDITION GUIDELINES 2 APA Sixth Edition Guidelines for Paper Formatting of the page. The abstract does not have paragraph indentation and is double spaced. It is okay to use

  5. Guidance, Navigation and Control Conference, August 16-19 2007, Hilton Head, South Carolina Parameterized Optimal Trajectory Generation for

    E-Print Network [OSTI]

    Langelaan, Jack W.

    Guidance, Navigation and Control Conference, August 16-19 2007, Hilton Head, South Carolina as finely discretized tables. I. Introduction Unmanned aerial vehicles (uavs) have played an integral role by the American Institute of Aeronautics and Astronautics, Inc. with permission. aStrictly speaking slam

  6. Running head: STEREOTYPE THREAT IN OLDER ADULTS 1 Stereotype threat can enhance, as well as impair, older adults' memory

    E-Print Network [OSTI]

    Mather, Mara

    Running head: STEREOTYPE THREAT IN OLDER ADULTS 1 Stereotype threat can enhance, as well as impair, and Rico Velasco for research assistance and to Dr. Tom Hess for providing us with the stereotype threat for publication. #12;STEREOTYPE THREAT IN OLDER ADULTS 2 Abstract (150) Negative stereotypes about aging can

  7. R163B -Eye movements and time-based selection Running head: EYE MOVEMENTS AND TIME-BASED SELECTION

    E-Print Network [OSTI]

    Inglis, Matthew

    R163B - Eye movements and time-based selection Running head: EYE MOVEMENTS AND TIME-BASED SELECTION Eye movements and time-based selection: Where do the eyes go in preview search? Derrick G. Watson.g.watson@warwick.ac.uk 1 #12;R163B - Eye movements and time-based selection Abstract In visual search tasks, presenting one

  8. Head-on beam-beam collisions with high intensities and long range beam-beam studies in the LHC

    E-Print Network [OSTI]

    Albert, M; Assmann, R; Buffat, X; Calaga, R; Cornelis, K; Fitterer, M; Giachino, R; Herr, W; Miyamoto, R; Norman, L; Papotti, G; Pieloni, T; Ponce, L; Redaelli, S; Schaumann, M; Trad, G; Wollmann, D

    2011-01-01T23:59:59.000Z

    In two experiments we studied possible limitations due to the beam-beam effects in the LHC. In the first experiment we collided high intensity bunches head-on to explore the region for high luminosity collisions. In the second test we reduced the crossing angle in the presence of long range encounters to increase their effects.

  9. Running Head: Ecosystem Energy and Conservation1 Ecosystem Energy as a Framework for Prioritizing Conservation Vulnerabilities and3

    E-Print Network [OSTI]

    Hansen, Andrew J.

    1 Running Head: Ecosystem Energy and Conservation1 2 Ecosystem Energy as a Framework for Prioritizing Conservation Vulnerabilities and3 Management Strategies4 5 Andrew James Hansen6 Ecology property, ecosystem energy levels, which,14 while once widely recognized as important, has received little

  10. Running Head: The Autonomic Nervous System's responses to losses Loss aversion in the eye and in the heart: The

    E-Print Network [OSTI]

    Yechiam, Eldad

    Running Head: The Autonomic Nervous System's responses to losses Loss aversion in the eye and in the heart: The Autonomic Nervous System's responses to losses Guy Hochman and Eldad Yechiam Technion@tx.technion.ac.il #12;ANS responses to losses 2 Loss aversion in the eye and in the heart: The Autonomic Nervous System

  11. May 29, 2013 ACADEMIC POSITION PROFILE APP. 209 TITLE: New Jersey Regional Studies Librarian and Head of Public Services

    E-Print Network [OSTI]

    Hanson, Stephen José

    . The New Jersey Regional Studies Librarian and Head of Public Services will: In collaboration with other including electronic publications relating to the State and region Enhance access to the Sinclair New service and collection management staff Direct and coordinate public service activities in the SC

  12. CGD Staff and Visitor List Blackmon, Maurice Director Hack, James (head) Anderson, Jeff (long-term visitor)

    E-Print Network [OSTI]

    , Lesley Mahowald, Natalie Norton, Nancy Stepaniak, Dave Marcum, Erika Schramm, Julie Wigley, Tom McKeown, Rebecca Yeager, Stephen Oleson, Keith Rosenbloom, Nan Jeff Kiehl Project Leader Stephens, Britt Lydia, Doug (head) Keith Lindsay Bettge, Tom Bengtsson, Thomas (long-term visitor) Brady, Esther Furrer

  13. Is social-emotional development a predictor of school success in Head Start children? A field study

    E-Print Network [OSTI]

    Team, Rachel Marie

    2009-06-02T23:59:59.000Z

    -emotional development in the beginning and end of one school year. Approximately 150 children ages 3 to 5 years old were assessed in six Head Start centers in different cities in rural Texas. Each student participated in an academic screening within the first 45 days...

  14. Central auditory neurons display flexible feature recombination1 Running head: Flexible logic of central auditory neurons3

    E-Print Network [OSTI]

    Gentner, Timothy

    these operations in individual neurons, violating the fixed neuron-to-38 computation mapping posited in the state but are generic, the flexible neuron-to-computation mapping43 demonstrated in this study in the auditory system1 Central auditory neurons display flexible feature recombination1 functions2 Running head

  15. Multi-vehicle Convoy Analysis Based on ANPR data A. Homayounfar*, A. T. S. Ho*, N. Zhu*, G. Head

    E-Print Network [OSTI]

    Doran, Simon J.

    Multi-vehicle Convoy Analysis Based on ANPR data A. Homayounfar*, A. T. S. Ho*, N. Zhu*, G. Head mining techniques for convoy analysis of vehicles based on the automatic number plate recognition (ANPR of multi-vehicle convoy activities. 1 Introduction Convoy Analysis of vehicles is a relatively new research

  16. HARMONIC FUNCTIONS FOR SEA-SURFACE TEMPERATURES AND SALINITIES, KOKO HEAD, OAHU, 1956-69, AND SEA-SURFACE

    E-Print Network [OSTI]

    HARMONIC FUNCTIONS FOR SEA-SURFACE TEMPERATURES AND SALINITIES, KOKO HEAD, OAHU, 1956-69, AND SEA-SURFACE TEMPERATURES, CHRISTMAS ISLAND, 1954-69 GUNTHER It SECKEL' AND MARIAN Y. Y. YONG' ABSTRACT Harmonic functions, with daily sampling, are on average 0.07° C. Harmonic analysis spanning the entire sampling duration shows

  17. Using MR equations built from summary data 1 Running head: Using MR equations built from summary data

    E-Print Network [OSTI]

    Crawford, John R.

    Using MR equations built from summary data 1 Running head: Using MR equations built from summary, United Kingdom. E-mail: j.crawford@abdn.ac.uk #12;Using MR equations built from summary data 2 Abstract; regression equations; single-case methods #12;Using MR equations built from summary data 3 INTRODUCTION

  18. Running head: Virtual Peer Technology for Children with Autism Using Virtual Peer Technology as an Intervention for Children with Autism

    E-Print Network [OSTI]

    Cassell, Justine

    an affinity for computers. Instead of labeling these technologies as useless for children with ASD1 Running head: Virtual Peer Technology for Children with Autism Using Virtual Peer Technology of key features that we believe to be important and as yet undervalued -- in technological

  19. Simulations of the Nuclear Recoil Head-Tail Signature in Gases Relevant to Directional Dark Matter Searches

    E-Print Network [OSTI]

    P. Majewski; D. Muna; D. P. Snowden-Ifft; N. J. C. Spooner

    2009-02-25T23:59:59.000Z

    We present the first detailed simulations of the head-tail effect relevant to directional Dark Matter searches. Investigations of the location of the majority of the ionization charge as being either at the beginning half (tail) or at the end half (head) of the nuclear recoil track were performed for carbon and sulphur recoils in 40 Torr negative ion carbon disulfide and for fluorine recoils in 100 Torr carbon tetrafluoride. The SRIM simulation program was used, together with a purpose-written Monte Carlo generator, to model production of ionizing pairs, diffusion and basic readout geometries relevant to potential real detector scenarios, such as under development for the DRIFT experiment. The results clearly indicate the existence of a head-tail track asymmetry but with a magnitude critically influenced by two competing factors: the nature of the stopping power and details of the range straggling. The former tends to result in the tail being greater than the head and the latter the reverse.

  20. RUNNING HEAD: Subaerial Exposure Unconformities on the Vercors Carbonate Platform Subaerial Exposure Unconformities on the Vercors Carbonate Platform (SE France)

    E-Print Network [OSTI]

    Fouke, Bruce W.

    1 RUNNING HEAD: Subaerial Exposure Unconformities on the Vercors Carbonate Platform Subaerial Exposure Unconformities on the Vercors Carbonate Platform (SE France) and their Sequence Stratigraphic carbonate platform (SE France), shows that the most prominent break in depositional style does not coincide

  1. Final Report - Inspection Limit Confirmation for Upper Head Penetration Nozzle Cracking

    SciTech Connect (OSTI)

    Anderson, Michael T.; Rudland, David L.; Zhang, Tao; Wilkowski, Gery M.

    2008-08-22T23:59:59.000Z

    The ASME Code Case N-729-1 defines alternative examination requirements for the Control Rod Drive Mechanism (CRDM) upper head penetration nozzle welds. The basis for these examination requirements was developed as part of an Industry program conducted by the Materials Reliability Program (MRP) through the Electric Power Research Institute (EPRI). The results of this program were published in MRP-95 Rev. 1 and document a set of finite element weld residual stress analyses conducted on a variety of upper head penetration nozzles. The inspection zone selected by the industry was based on the stress where it was assumed that primary water stress corrosion cracking (PWSCC) would not initiate. As explained in MRP-95 Rev. 1, it has been illustrated that PWSCC does not occur in the Alloy 600 tube when the stresses are below the yield strength of that tube. Typical yield strengths at operating conditions for Alloy 600 range from 35 ksi to 65 ksi. A stress less than 20-ksi tension was chosen as a conservative range where PWSCC would not initiate. Over the last several years, Engineering Mechanics Corporation of Columbus (Emc2) has conducted welding residual stress analyses on upper head penetration J-welds made from Alloy 182 weld metal for the U.S. Nuclear Regulatory Commission (NRC) staff. These efforts were performed as a confirmatory evaluation of the industrys analyses conducted as part of their MRP-95 Rev. 1 effort. To this point, the analyses conducted by Emc2 have not been compared to the MRP-95 Rev. 1 results or the examination zones defined in the Code Case. Therefore, this report summarizes the past Emc2 CRDM welding analyses and investigates the regions where the welding stresses may be sufficiently high to promote stress corrosion cracking (SCC). In all, 90 welding residual stress analyses were conducted by Emc2 and the largest distance below the weld where the stress drops below 20 ksi was 5 inches for the uphill weld of the 53-degree nozzle case. For the largest distance above the weld where stress drops below 20 ksi, the worst case was 1.5 inches above the downhill side of the 25-degree nozzle case. The inspection zones described in both MRP-95 Rev. 1 and Code Case N-729-1 were set at 1.0 inch for nozzle angles greater than 30 degrees or 1.5 inches for nozzle angles less than 30 degrees, above the highest or below the lowest point on the weld. In all cases analyzed by Emc2 in this effort, there was only one case where the stress was above 20 ksi outside of this inspection zone. For that case, the stresses were very close to 20 ksi at the inspection zone limit and were considered acceptable.

  2. Tumor delineation using PET in head and neck cancers: Threshold contouring and lesion volumes

    SciTech Connect (OSTI)

    Ford, Eric C.; Kinahan, Paul E.; Hanlon, Lorraine; Alessio, Adam; Rajendran, Joseph; Schwartz, David L.; Phillips, Mark [University of Washington, Department of Radiation Oncology, 1959 N. E. Pacific Street, Seattle, Washington 98195 (United States) and Puget Sound Veterans Administration, 18801 S. Columbian Way, Seattle, Washington 98195 (United States); University of Washington, Department of Radiology, 1959 N. E. Pacific Street, Seattle, Washington 98195 (United States); University of Washington, Department of Radiation Oncology, 1959 N. E. Pacific Street, Seattle, Washington 98195 and School of Physics, University College Dublin (Ireland); University of Washington, Department of Radiology, 1959 N. E. Pacific Street, Seattle, Washington 98195 (United States); University of Texas, M.D. Anderson Cancer Center, Department of Radiation Oncology, 1515 Holcombe Blvd., Houston, Texas 77030 and Puget Sound Veterans Administration, 1880 S. Columbian Way, Seattle, Washington 98195 (United States); University of Washington, Department of Radiation Oncology, 1959 N. E. Pacific Street, Seattle, Washington 98195 (United States)

    2006-11-15T23:59:59.000Z

    Tumor boundary delineation using positron emission tomography (PET) is a promising tool for radiation therapy applications. In this study we quantify the uncertainties in tumor boundary delineation as a function of the reconstruction method, smoothing, and lesion size in head and neck cancer patients using FDG-PET images and evaluate the dosimetric impact on radiotherapy plans. FDG-PET images were acquired for eight patients with a GE Advance PET scanner. In addition, a 20 cm diameter cylindrical phantom with six FDG-filled spheres with volumes of 1.2 to 26.5 cm{sup 3} was imaged. PET emission scans were reconstructed with the OSEM and FBP algorithms with different smoothing parameters. PET-based tumor regions were delineated using an automatic contouring function set at progressively higher threshold contour levels and the resulting volumes were calculated. CT-based tumor volumes were also contoured by a physician on coregistered PET/CT patient images. The intensity value of the threshold contour level that returns 100% of the actual volume, I{sub V100}, was measured. We generated intensity-modulated radiotherapy (IMRT) plans for an example head and neck patient, treating 66 Gy to CT-based gross disease and 54 Gy to nodal regions at risk, followed by a boost to the FDG-PET-based tumor. The volumes of PET-based tumors are a sensitive function of threshold contour level for all patients and phantom datasets. A 5% change in threshold contour level can translate into a 200% increase in volume. Phantom data indicate that I{sub V100} can be set as a fraction, f, of the maximum measured uptake. Fractional threshold values in the cylindrical water phantom range from 0.23 to 0.51. Both the fractional threshold and the threshold-volume curve are dependent on lesion size, with lesions smaller than approximately 5 cm{sup 3} displaying a more pronounced sensitivity and larger fractional threshold values. The threshold-volume curves and fractional threshold values also depend on the reconstruction algorithm and smoothing filter with more smoothing requiring a higher fractional threshold contour level. The threshold contour level affects the tumor size, and therefore the ultimate boost dose that is achievable with IMRT. In an example head and neck IMRT plan, the D95 of the planning target volume decreased from 7770 to 7230 cGy for 42% vs 55% contour threshold levels. PET-based tumor volumes are strongly affected by the choice of threshold level. This can have a significant dosimetric impact. The appropriate threshold level depends on lesion size and image reconstruction parameters. These effects should be carefully considered when using PET contour and/or volume information for radiotherapy applications.

  3. Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system

    DOE Patents [OSTI]

    Kieper, Douglas Arthur; Majewski, Stanislaw; Welch, Benjamin L.

    2012-07-03T23:59:59.000Z

    An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

  4. On-Site Oxy-Lance Size Reduction of South Texas Project Reactor Vessel Heads - 12324

    SciTech Connect (OSTI)

    Posivak, Edward [WMG, inc. (United States); Keeney, Gilbert; Wheeler, Dean [Shaw Group (United States)

    2012-07-01T23:59:59.000Z

    On-Site Oxy-Lance size reduction of mildly radioactive large components has been accomplished at other operating plants. On-Site Oxy-Lance size reduction of more radioactive components like Reactor Vessel Heads had previously been limited to decommissioning projects. Building on past decommissioning and site experience, subcontractors for South Texas Project Nuclear Operating Company (STPNOC) developed an innovative integrated system to control smoke, radioactive contamination, worker dose, and worker safety. STP's innovative, easy to use CEDM containment that provided oxy lance access, smoke control, and spatter/contamination control was the key to successful segmentation for cost-effective and ALARA packaging and transport for disposal. Relative to CEDM milling, STP oxy-lance segmentation saved approximately 40 person- REM accrued during 9,000 hours logged into the radiological controlled area (RCA) during more than 3,800 separate entries. Furthermore there were no personnel contamination events or respiratory uptakes of radioactive material during the course of the entire project. (authors)

  5. Cascades of Multi-headed Chimera States for Coupled Phase Oscillators

    E-Print Network [OSTI]

    Yuri L. Maistrenko; Anna Vasylenko; Oleksandr Sudakov; Roman Levchenko; Volodymyr L. Maistrenko

    2014-07-25T23:59:59.000Z

    Chimera state is a recently discovered dynamical phenomenon in arrays of nonlocally coupled oscillators, that displays a self-organized spatial pattern of co-existing coherence and incoherence. We discuss the appearance of the chimera states in networks of phase oscillators with attractive and with repulsive interactions, i.e. when the coupling respectively favors synchronization or works against it. By systematically analyzing the dependence of the spatiotemporal dynamics on the level of coupling attractivity/repulsivity and the range of coupling, we uncover that different types of chimera states exist in wide domains of the parameter space as cascades of the states with increasing number of intervals of irregularity, so-called chimera's heads. We report three scenarios for the chimera birth: 1) via saddle-node bifurcation on a resonant invariant circle, also known as SNIC or SNIPER, 2) via blue-sky catastrophe, when two periodic orbits, stable and saddle, approach each other creating a saddle-node periodic orbit, and 3) via homoclinic transition with complex multistable dynamics including an "eight-like" limit cycle resulting eventually in a chimera state.

  6. Head Loss Evaluation in a PWR Reactor Vessel Using CFD Analysis

    SciTech Connect (OSTI)

    Ji Hwan Jeong; Jong Pil Park [School of Mechanical Engineering, Pusan National University, Enesys Jangjeon-dong, Geumjeong-gu, Busan (Korea, Republic of); Byoung-Sub Han [Jangdae-dong, Yusong-gu, Daejeon (Korea, Republic of)

    2006-07-01T23:59:59.000Z

    Nuclear vendors and utilities perform lots of simulations and analyses in order to ensure the safe operation of nuclear power plants (NPPs). In general, the simulations are carried out using vendor-specific design codes and best-estimate system analysis codes and most of them were developed based on 1-dimensional lumped parameter models. During the past decade, however, computers, parallel computation methods, and 3-dimensional computational fluid dynamics (CFD) codes have been dramatically enhanced. It is believed to be beneficial to take advantage of advanced commercial CFD codes in safety analysis and design of NPPs. The present work aims to analyze the flow distribution in downcomer and lower plenum of Korean standard nuclear power plants (KSNPs) using STAR-CD. The lower plenum geometry of a PWR is very complicated since there are so many reactor internals, which hinders in CFD analysis for real reactor geometry up to now. The present work takes advantage of 3D CAD model so that real geometry of lower plenum is used. The results give a clear figure about flow fields in the reactor vessel, which is one of major safety concerns. The calculated pressure drop across downcomer and lower plenum appears to be in good agreement with the data in engineering calculation note. A algorithm which can evaluate head loss coefficient which is necessary for thermal-hydraulic system code running was suggested based on this CFD analysis results. (authors)

  7. Is one head and neck immobilization system as good as another? One center's experience

    SciTech Connect (OSTI)

    Lord, Leah Bapp; May, Sharon; Bailey, Michael; Smith, Leigh

    2003-03-31T23:59:59.000Z

    The William Buckland Radiotherapy Center has used 2 different immobilization systems for patients requiring radiotherapy to the head-and-neck region. A polycarbonate mask was manufactured for radical treatments and a thermoplastic mask for palliative treatments. This study evaluated field placement accuracy, staff opinion, and production costs of both systems. The manual matching program of Varian PortalVision Electronic Portal Imaging (EPI) System was used to assess field placement accuracy on a daily basis. Radiation therapists (RTs) were surveyed before and after the study to determine their opinions of each system. Production time and required materials were recorded to assess cost. Nineteen patients from each system had daily EPI results compiled with no statistically significant difference observed in field placement accuracy. The thermoplastic system was found to be more cost efficient due to a combination of the reduced production time and reuseability of the masks. User acceptability of the thermoplastic system has increased so that it is now the preferred system. In conclusion, the thermoplastic system is a viable alternative to the polycarbonate system in terms of treatment accuracy and cost. It is recommended that the thermoplastic system be used for all radical and palliative treatments. In addition, RTs prefer the thermoplastic system.

  8. Dentalmaps: Automatic Dental Delineation for Radiotherapy Planning in Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Thariat, Juliette, E-mail: jthariat@hotmail.com [Department of Radiation Oncology/Institut de biologie et developpement du cancer (IBDC) centre national de la recherche scientifique (CNRS) unite mixte de recherche UMR 6543, Cancer Center Antoine-Lacassagne, University of Nice Sophia-Antipolis, Nice Cedex (France); Ramus, Liliane [DOSIsoft, Cachan (France); INRIA (Institut National de Recherche en Automatique et en Automatique)-Asclepios Research Project, Sophia-Antipolis (France); Maingon, Philippe [Department of Radiation Oncology, Centre Georges-Francois Leclerc, Dijon Cedex (France); Odin, Guillaume [Department of Head-and-Neck Surgery, Centre Hospitalier Universitaire-Institut Universitaire de la Face et du Cou, Nice Cedex (France); Gregoire, Vincent [Department of Radiation Oncology, St.-Luc University Hospital, Brussels (Belgium); Darcourt, Vincent [Department of Radiation Oncology-Dentistry, Cancer Center Antoine-Lacassagne, University of Nice Sophia-Antipolis, Nice Cedex (France); Guevara, Nicolas [Department of Head-and-Neck Surgery, Centre Hospitalier Universitaire-Institut Universitaire de la Face et du Cou, Nice Cedex (France); Orlanducci, Marie-Helene [Department of Odontology, CHU, Nice (France); Marcie, Serge [Department of Radiation Oncology/Institut de biologie et developpement du cancer (IBDC) centre national de la recherche scientifique (CNRS) unite mixte de recherche UMR 6543, Cancer Center Antoine-Lacassagne, University of Nice Sophia-Antipolis, Nice Cedex (France); Poissonnet, Gilles [Department of Head-and-Neck Surgery, Cancer Center Antoine-Lacassagne-Institut Universitaire de la Face et du Cou, Nice Cedex (France); Marcy, Pierre-Yves [Department of Radiology, Cancer Center Antoine-Lacassagne, University of Nice Sophia-Antipolis, Nice Cedex (France); and others

    2012-04-01T23:59:59.000Z

    Purpose: To propose an automatic atlas-based segmentation framework of the dental structures, called Dentalmaps, and to assess its accuracy and relevance to guide dental care in the context of intensity-modulated radiotherapy. Methods and Materials: A multi-atlas-based segmentation, less sensitive to artifacts than previously published head-and-neck segmentation methods, was used. The manual segmentations of a 21-patient database were first deformed onto the query using nonlinear registrations with the training images and then fused to estimate the consensus segmentation of the query. Results: The framework was evaluated with a leave-one-out protocol. The maximum doses estimated using manual contours were considered as ground truth and compared with the maximum doses estimated using automatic contours. The dose estimation error was within 2-Gy accuracy in 75% of cases (with a median of 0.9 Gy), whereas it was within 2-Gy accuracy in 30% of cases only with the visual estimation method without any contour, which is the routine practice procedure. Conclusions: Dose estimates using this framework were more accurate than visual estimates without dental contour. Dentalmaps represents a useful documentation and communication tool between radiation oncologists and dentists in routine practice. Prospective multicenter assessment is underway on patients extrinsic to the database.

  9. Head-on collision of dust-acoustic shock waves in strongly coupled dusty plasmas

    SciTech Connect (OSTI)

    EL-Shamy, E. F., E-mail: emadel-shamy@hotmail.com [Department of physics, Faculty of Science, Damietta University, New Damietta 34517 (Egypt); Department of Physics, College of Science, King Khalid University, P.O. 9004, Abha (Saudi Arabia); Al-Asbali, A. M., E-mail: aliaa-ma@hotmail.com [Department of Physics, College of Science for Girls in Abha, King Khalid University, Abha, P.O. 960 (Saudi Arabia)

    2014-09-15T23:59:59.000Z

    A theoretical investigation is carried out to study the propagation and the head-on collision of dust-acoustic (DA) shock waves in a strongly coupled dusty plasma consisting of negative dust fluid, Maxwellian distributed electrons and ions. Applying the extended PoincarLighthillKuo method, a couple of KortewegdeVriesBurgers equations for describing DA shock waves are derived. This study is a first attempt to deduce the analytical phase shifts of DA shock waves after collision. The impacts of physical parameters such as the kinematic viscosity, the unperturbed electron-to-dust density ratio, parameter determining the effect of polarization force, the ion-to-electron temperature ratio, and the effective dust temperature-to-ion temperature ratio on the structure and the collision of DA shock waves are examined. In addition, the results reveal the increase of the strength and the steepness of DA shock waves as the above mentioned parameters increase, which in turn leads to the increase of the phase shifts of DA shock waves after collision. The present model may be useful to describe the structure and the collision of DA shock waves in space and laboratory dusty plasmas.

  10. Thermal modeling of head disk interface system in heat assisted magnetic recording

    SciTech Connect (OSTI)

    Vemuri, Sesha Hari; Seung Chung, Pil; Jhon, Myung S., E-mail: mj3a@andrew.cmu.edu [Department of Chemical Engineering and Data Storage Systems Center, Carnegie Mellon University, 5000 Forbes Ave., Pittsburgh, Pennsylvania 15213 (United States); Min Kim, Hyung [Department of Mechanical System Engineering, Kyonggi University, Suwon, Gyeonggi-do 440-746 (Korea, Republic of)

    2014-05-07T23:59:59.000Z

    A thorough understanding of the temperature profiles introduced by the heat assisted magnetic recording is required to maintain the hotspot at the desired location on the disk with minimal heat damage to other components. Here, we implement a transient mesoscale modeling methodology termed lattice Boltzmann method (LBM) for phonons (which are primary carriers of energy) in the thermal modeling of the head disk interface (HDI) components, namely, carbon overcoat (COC). The LBM can provide more accurate results compared to conventional Fourier methodology by capturing the nanoscale phenomena due to ballistic heat transfer. We examine the in-plane and out-of-plane heat transfer in the COC via analyzing the temperature profiles with a continuously focused and pulsed laser beam on a moving disk. Larger in-plane hotspot widening is observed in continuously focused laser beam compared to a pulsed laser. A pulsed laser surface develops steeper temperature gradients compared to continuous hotspot. Furthermore, out-of-plane heat transfer from the COC to the media is enhanced with a continuous laser beam then a pulsed laser, while the temperature takes around 140 fs to reach the bottom surface of the COC. Our study can lead to a realistic thermal model describing novel HDI material design criteria for the next generation of hard disk drives with ultra high recording densities.

  11. Investigation of Head Burns in Adult Salmonids : Phase 1 : Examination of Fish at Lower Granite Dam, July 2, 1996. Final Report.

    SciTech Connect (OSTI)

    Elston, Ralph

    1996-08-01T23:59:59.000Z

    Head burn is a descriptive clinical term used by fishery biologists to describe exfoliation of skin and underlying connective tissue of the jaw and cranial region of salmonids, observed at fish passage facilities on the Columbia and Snake Rivers. The observations are usually made on upstream migrant adult salmon or steelhead. An expert panel, convened in 1996, to evaluate the risk and severity of gas bubble disease (GBD) in the Snake and Columbia River system believed that, while head burns appeared to be distinct from GBD, the relationship between dissolved gas saturation in the rivers and head burns was uncertain.

  12. Read/write head having a GMR sensor biased by permanent magnets located between the GMR and the pole shields

    DOE Patents [OSTI]

    Yuan, Samuel W. (San Carlos, CA); Rottmayer, Robert Earl (Fremont, CA); Carey, Matthew J. (San Jose, CA)

    1999-01-01T23:59:59.000Z

    A compact read/write head having a biased giant magnetoresistive sensor. Permanent magnet films are placed adjacent to the giant magnetoresistive sensor operating in the current-perpendicular-to the-plane (Cpp) mode and spaced with respect to the sensor by conducting films. These permanent magnet films provide a magnetic bias. The bias field is substantial and fairly uniform across sensor height. Biasing of the giant magnetoresistive sensor provides distinguishable response to the rising and falling edges of a recorded pulse on an adjacent recording medium, improves the linearity of the response, and helps to reduce noise. This read/write head is much simpler to fabricate and pattern and provides an enhanced uniformity of the bias field throughout the sensor.

  13. On Comparing the Quality of Head and Neck Imrt Plans Delivered with Two Different Linear Accelerator Manufacturers

    SciTech Connect (OSTI)

    Basran, Parminder S., E-mail: pbasran@bccancer.bc.c [Department of Medical Physics, Odette Cancer Centre, Toronto, Ontario (Canada); Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Balogh, Judith; Poon, Ian; MacKenzie, Robert [Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Department of Radiation Oncology, Odette Cancer Centre, Toronto, Ontario (Canada); Chan, Timothy [Department of Medical Sciences, University of Western Ontario, Toronto, Ontario (Canada)

    2011-04-01T23:59:59.000Z

    The purpose of this work was to determine whether 2 different types of linear accelerators manufacturers with similar MLC leaf widths deliver equivalent IMRT distributions for head and neck radiotherapy patients. In this study, plans delivered with Siemens linacs were re-optimized with an Elekta linac and vice versa. To test for significance, paired t-tests were computed to examine differences in target and normal tissue doses and monitor units. Dose distributions, dose-volume histograms, and dose to targets and normal tissues were found to be equivalent irrespective of the linac type. However, approximately 15% more monitor units were delivered when planned on the Elekta machine (p < 0.002). Both linear accelerators provide plans of comparable dosimetric quality; however, Elekta machines deliver slightly more monitor units than Siemens machines. This increase is likely due differences in geometric properties of the machine head designs, as modeled in the treatment planning system.

  14. Head on collision of multi-solitons in an electron-positron-ion plasma having superthermal electrons

    SciTech Connect (OSTI)

    Roy, Kaushik, E-mail: kaushikbolpur@rediffmail.com [Beluti M. K. M. High School, P.O. Beluti, Birbhum, West Bengal 731301 (India); Chatterjee, Prasanta, E-mail: prasantachatterjee1@rediffmail.com; Roychoudhury, Rajkumar [Department of Mathematics, Siksha Bhavana Visva Bharati, Santiniketan 731235 (India)

    2014-10-15T23:59:59.000Z

    The head-on collision and overtaking collision of four solitons in a plasma comprising superthermal electrons, cold ions, and Boltzmann distributed positrons are investigated using the extended Poincare-Lighthill-Kuo (PLK) together with Hirota's method. PLK method yields two separate Korteweg-de Vries (KdV) equations where solitons obtained from any KdV equation move along a direction opposite to that of solitons obtained from the other KdV equation, While Hirota's method gives multi-soliton solution for each KdV equation all of which move along the same direction where the fastest moving soliton eventually overtakes the other ones. We have considered here two soliton solutions obtained from Hirota's method. Phase shifts acquired by each soliton due to both head-on collision and overtaking collision are calculated analytically.

  15. The effect of head-on beam-beam compensation on the stochastic boundaries and particle diffusion in RHIC.

    SciTech Connect (OSTI)

    Abreu,N.; Beebe-Wang, J.; FischW; Luo, Y.; Robert-Demolaize, G.

    2008-06-23T23:59:59.000Z

    To compensate the effects from the head-on beam-beam interactions in the polarized proton operation in the Relativistic Heavy Ion Collider (RHIC), an electron lens (elens) is proposed to collide head-on with the proton beam. We used an extended version of SixTrack for multiparticle beam-beam simulation in order to study the effect of the e-lens on the stochastic boundary and also on diffusion. The stochastic boundary was analyzed using Lyapunov exponents and the diffusion was characterized as the increase in the rms spread of the action. For both studies the simulations were performed with and without the e-lens and with full and partial compensation. Using the simulated values of the diffusion an attempt to calculate the emittance growth rate is presented.

  16. Lower head creep rupture failure analysis associated with alternative accident sequences of the Three Mile Island Unit 2

    SciTech Connect (OSTI)

    Sang Lung, Chan [Swiss Federal Institute of Technology Zurich and Swiss Federal Nuclear Safety Inspectorate, Zurich, Switzerland, 8001 (Switzerland)

    2004-07-01T23:59:59.000Z

    The objective of this lower head creep rupture analysis is to assess the current version of MELCOR 1.8.5-RG against SCDAP/RELAP5 MOD 3.3kz. The purpose of this assessment is to investigate the current MELCOR in-vessel core damage progression phenomena including the model for the formation of a molten pool. The model for stratified molten pool natural heat transfer will be included in the next MELCOR release. Presently, MELCOR excludes the gap heat-transfer model for the cooling associated with the narrow gap between the debris and the lower head vessel wall. All these phenomenological models are already treated in SCDAP/RELAP5 using the COUPLE code to model the heat transfer of the relocated debris with the lower head based on a two-dimensional finite-element-method. The assessment should determine if current MELCOR capabilities adequately cover core degradation phenomena appropriate for the consolidated MELCOR code. Inclusion of these features should bring MELCOR much closer to a state of parity with SCDAP/RELAP5 and is a currently underway element in the MELCOR code consolidation effort. This assessment deals with the following analysis of the Three Mile Island Unit 2 (TMI-2) alternative accident sequences. The TMI-2 alternative accident sequence-1 includes the continuation of the base case of the TMI-2 accident with the Reactor Coolant Pumps (RCP) tripped, and the High Pressure Injection System (HPIS) throttled after approximately 6000 s accident time, while in the TMI-2 alternative accident sequence-2, the reactor coolant pumps is tripped after 6000 s and the HPIS is activated after 12,012 s. The lower head temperature distributions calculated with SCDAP/RELAP5 are visualized and animated with open source visualization freeware 'OpenDX'. (author)

  17. Effect of Radiotherapy Interruptions on Survival in Medicare Enrollees With Local and Regional Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Fesinmeyer, Megan Dann [Fred Hutchinson Cancer Research Center, Seattle, WA (United States); Mehta, Vivek [Swedish Medical Center, Seattle, WA (United States); Blough, David [Fred Hutchinson Cancer Research Center, Seattle, WA (United States); School of Pharmacy, University of Washington, Seattle, WA (United States); Tock, Lauri [Fred Hutchinson Cancer Research Center, Seattle, WA (United States); Ramsey, Scott D., E-mail: sramsey@fhcrc.or [Fred Hutchinson Cancer Research Center, Seattle, WA (United States); School of Pharmacy, University of Washington, Seattle, WA (United States)

    2010-11-01T23:59:59.000Z

    Purpose: To investigate whether interruptions in radiotherapy are associated with decreased survival in a population-based sample of head-and-neck cancer patients. Methods and Materials: Using the Surveillance, Epidemiology, and End Results-Medicare linked database we identified Medicare beneficiaries aged 66 years and older diagnosed with local-regional head-and-neck cancer during the period 1997-2003. We examined claims records of 3864 patients completing radiotherapy for the presence of one or more 5-30-day interruption(s) in therapy. We then performed Cox regression analyses to estimate the association between therapy interruptions and survival. Results: Patients with laryngeal tumors who experienced an interruption in radiotherapy had a 68% (95% confidence interval, 41-200%) increased risk of death, compared with patients with no interruptions. Patients with nasal cavity, nasopharynx, oral, salivary gland, and sinus tumors had similar associations between interruptions and increased risk of death, but these did not reach statistical significance because of small sample sizes. Conclusions: Treatment interruptions seem to influence survival time among patients with laryngeal tumors completing a full course of radiotherapy. At all head-and-neck sites, the association between interruptions and survival is sensitive to confounding by stage and other treatments. Further research is needed to develop methods to identify patients most susceptible to interruption-induced mortality.

  18. Impact of Concomitant Chemotherapy on Outcomes of Radiation Therapy for Head-and-Neck Cancer: A Population-Based Study

    SciTech Connect (OSTI)

    Gupta, Shlok; Kong, Weidong [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Booth, Christopher M. [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Department of Oncology, Queens University, Kingston, Ontario (Canada); Mackillop, William J., E-mail: william.mackillop@krcc.on.ca [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Department of Oncology, Queens University, Kingston, Ontario (Canada); Department of Community Health and Epidemiology, Queens University, Kingston, Ontario (Canada)

    2014-01-01T23:59:59.000Z

    Purpose: Clinical trials have shown that the addition of chemotherapy to radiation therapy (RT) improves survival in advanced head-and-neck cancer. The objective of this study was to describe the effectiveness of concomitant chemoradiation therapy (C-CRT) in routine practice. Methods and Materials: This was a population-based cohort study. Electronic records of treatment from all provincial cancer centers were linked to a population--based cancer registry to describe the adoption of C-CRT for head-and-neck cancer patients in Ontario, Canada. The study population was then divided into pre- and postadoption cohorts, and their outcomes were compared. Results: Between 1992 and 2008, 18,867 patients had diagnoses of head-and-neck cancer in Ontario, of whom 7866 (41.7%) were treated with primary RT. The proportion of primary RT cases that received C-CRT increased from 2.2% in the preadoption cohort (1992-1998) to 39.3% in the postadoption cohort (2003-2008). Five-year survival among all primary RT cases increased from 43.6% in the preadoption cohort to 51.8% in the postadoption cohort (P<.001). Over the same period, treatment-related hospital admissions increased significantly, but there was no significant increase in treatment-related deaths. Conclusions: C-CRT was widely adopted in Ontario after 2003, and its adoption was temporally associated with an improvement in survival.

  19. Installation of the Monitoring Site at the Los Alamos Canyon Low-Head Weir

    SciTech Connect (OSTI)

    W.J.Stone; D.L.Newell

    2002-08-01T23:59:59.000Z

    The Cerro Grande fire of 2000 had an enormously adverse impact on and around Los Alamos National Laboratory (LANL). Immediately there were concerns about the potential for enhanced runoff/offsite transport of contaminant-laden sediments because of watershed damage. In response to this concern, the U.S. Army Corps of Engineers installed a low-head weir in Los Alamos Canyon near the White Rock ''Y.'' However, the occurrence of fractured basalt at the surface and ponding of runoff behind the weir enhance the possibility of downward migration of contaminants. Therefore, three boreholes were drilled on the south bank of the channel by LANL to provide a means of monitoring the impact of the Cerro Grande fire and of the weir on water quality beneath the canyon. The boreholes and associated instrumentation are referred to as the Los Alamos Weir Site (LAWS). The three boreholes include a vertical hole and two angled holes (one at approximately 45{sup o} and one at approximately 30{sup o}). Since the basalt is highly fractured, the holes would not stay open. Plans called for inserting flexible liners into all holes. However, using liners in such unstable ground was problematic and, in the angled holes, required deployment through scalloped or perforated polyvinyl chloride (PVC) shield. The vertical hole (LAWS-01), drilled to a total depth of 281.5 ft below ground surface (bgs), was completed as a 278-ft deep monitoring well with four screens: one targeting shallow perched water encountered at 80 ft, two in what may correspond to the upper perched zone at regional groundwater characterization well R-9i (1/4 mi. to the west), and one in what may correspond to the lower perched zone at R-9i. A Water FLUTe{trademark} system deployed in the well isolates the screened intervals; associated transducers and sampling ports permit monitoring head and water quality in the screened intervals. The second hole (LAWS-02), drilled at an angle of 43{sup o} from horizontal, is 156 ft long and bottoms at a depth of 106 ft bgs. The shallow perched water seen at LAWS-01 (at 80 ft) was not encountered. A scalloped PVC shield was installed to keep the hole open while permitting flexible liners to contact the borehole wall. It was initially instrumented with a color-reactive liner to locate water-producing fractures. That was later replaced by an absorbent liner to collect water from the vadose zone. The third hole (LAWS-03), drilled at an angle of 34{sup o} from horizontal, initially had a length of 136 ft and bottomed at a depth of 76 ft bgs. However, the PVC shield rotated during installation such that scallops were at the top and rock debris repeatedly fell in, preventing liner insertion. While pulling the scalloped PVC to replace it with a perforated PVC shield that did not require orientation, the scalloped PVC broke and only 85 ft was recovered. The hole was blocked at that position and could not be drilled out with the equipment available. Thus, LAWS-03 was completed at a length of 85 ft and a depth of 40 ft bgs. An absorbent liner was installed at the outset in preparation for the 2002 summer monsoon season. The entire monitoring site is enclosed inside a locked, 8-ft-high chainlink fence for security. The liners used in the angled boreholes carry electrical wire pairs to detect soil-moisture changes. Surface-water data are provided by stream gages above and below the weir site. Depth of ponding behind the weir is provided by a gage installed just behind the structure.

  20. Adaptive Radiotherapy for Head-and-Neck Cancer: Initial Clinical Outcomes From a Prospective Trial

    SciTech Connect (OSTI)

    Schwartz, David L., E-mail: dschwartz3@nshs.edu [Department of Radiation Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, New Hyde Park, NY (United States); Feinstein Institute for Medical Research, Manhasset, NY (United States); Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX (United States); Garden, Adam S.; Thomas, Jimmy [Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX (United States); Chen Yipei; Zhang Yongbin [Department of Radiation Physics, University of Texas M.D. Anderson Cancer Center, Houston, TX (United States); Lewin, Jan; Chambers, Mark S. [Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, TX (United States); Dong, Lei [Department of Radiation Physics, University of Texas M.D. Anderson Cancer Center, Houston, TX (United States)

    2012-07-01T23:59:59.000Z

    Purpose: To present pilot toxicity and survival outcomes for a prospective trial investigating adaptive radiotherapy (ART) for oropharyngeal squamous cell carcinoma. Methods and Materials: A total of 24 patients were enrolled in an institutional review board-approved clinical trial; data for 22 of these patients were analyzed. Daily CT-guided setup and deformable image registration permitted serial mapping of clinical target volumes and avoidance structures for ART planning. Primary site was base of tongue in 15 patients, tonsil in 6 patient, and glossopharyngeal sulcus in 1 patient. Twenty patients (91%) had American Joint Committee on Cancer (AJCC) Stage IV disease. T stage distribution was 2 T1, 12 T2, 3 T3, 5 T4. N stage distribution was 1 N0, 2 N1, 5 N2a, 12 N2b, and 2 N2c. Of the patients, 21 (95%) received systemic therapy. Results: With a 31-month median follow-up (range, 13-45 months), there has been no primary site failure and 1 nodal relapse, yielding 100% local and 95% regional disease control at 2 years. Baseline tumor size correlated with absolute volumetric treatment response (p = 0.018). Parotid volumetric change correlated with duration of feeding tube placement (p = 0.025). Acute toxicity was comparable to that observed with conventional intensity-modulated radiotherapy (IMRT). Chronic toxicity and functional outcomes beyond 1 year were tabulated. Conclusion: This is the first prospective evaluation of morbidity and survival outcomes in patients with locally advanced head-and-neck cancer treated with automated adaptive replanning. ART can provide dosimetric benefit with only one or two mid-treatment replanning events. Our preliminary clinical outcomes document functional recovery and preservation of disease control at 1-year follow-up and beyond.

  1. Comparison of Methods to Reduce Dose to Swallowing-Related Structures in Head and Neck Cancer

    SciTech Connect (OSTI)

    Caudell, Jimmy J., E-mail: jjcaudell@gmail.co [Department of Radiation Oncology, University of Alabama at Birmingham (United States); Burnett, Omer L.; Schaner, Philip E.; Bonner, James A.; Duan Jun [Department of Radiation Oncology, University of Alabama at Birmingham (United States)

    2010-06-01T23:59:59.000Z

    Introduction: Emerging data suggest that reduction of dose to the larynx and pharyngeal constrictor may lower the risk of swallowing complications such as long-term gastrostomy dependence and aspiration. Organ avoidance becomes difficult when the primary tumor or involved nodes are present at the level of the larynx. Materials and Methods: Fifteen patients with Stage III-IV squamous cell carcinoma of the head and neck with high-dose target volume at the level of the larynx (but not involving the glottic larynx) were planned with whole-field IMRT (WF-IMRT), as well as a low anterior neck field dynamically matched to an IMRT plan (D-SCLV). Plans were compared with respect to coverage of targets and sparing of normal tissues including the larynx, inferior pharyngeal constrictor (IPC), parotid, and cord. Results: There was no significant difference between the two techniques in coverage of the high- or intermediate-dose planning target volumes (PTVs). Coverage of the elective nodal PTV was inferior with the D-SCLV technique, with a mean of 96.5% vs. 86.3% of the volume receiving the prescription dose (p = 0.001) compared with WF-IMRT plans. However, the D-SCLV technique significantly reduced mean dose to the larynx (43.7 vs. 46.7 Gy, p = 0.05) and IPC (39.1 vs. 46.1 Gy, p = 0.002). There was no significant difference in dose to the parotid or cord. Conclusion: Given the steep dose responses seen in studies examining the association between swallowing toxicity and dose to the larynx and IPC, dose reductions using the D-SCLV technique may be clinically significant.

  2. The Journal of Neuroscience, February 1990, fO(2): 420-435 Head-Direction Cells Recorded from the Postsubiculum in Freely

    E-Print Network [OSTI]

    Sereno, Martin

    /computer system monitored cell discharge while simultaneously tracking the position of 2 colored light emitting diodes (LEDs) secured to the animal's head. The animal's location was calculated from the position of one

  3. Laboratory evaluation of the constant rate of strain and constant head techniques for measurement of the hydraulic conductivity of fine grained soils

    E-Print Network [OSTI]

    Adams, Amy Lynn

    2011-01-01T23:59:59.000Z

    This thesis evaluates the constant rate of strain and constant head techniques for measurement of the hydraulic conductivity of fine grained soils. A laboratory program compares hydraulic conductivity measurements made ...

  4. Effect of Recombinant Human Deoxyribonuclease on Oropharyngeal Secretions in Patients With Head-and-Neck Cancers Treated With Radiochemotherapy

    SciTech Connect (OSTI)

    Mittal, Bharat B., E-mail: bmittal@nmh.org [Department of Radiation Oncology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois (United States); Wang, Edward [Department of Surgery, Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois (United States); Sejpal, Samir [Department of Radiation Oncology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois (United States); Agulnik, Mark [Section of Medical Oncology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois (United States); Mittal, Amit [Yale University, New Haven, Connecticut (United States); Harris, Kirk [Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado (United States)

    2013-10-01T23:59:59.000Z

    Purpose: The current study examined the effect of recombinant human deoxyribonuclease (rhDNase) on quality of life (QOL) measures, clinical improvement, and DNA content of thick oropharyngeal secretions (OPS) in patients with head-and-neck (H and N) cancers. Methods and Materials: Thirty-six patients with local-regional advanced H and N cancer receiving chemoradiationtherapy (CRT) were randomized to receive either placebo or rhDNase. Endpoints included MD Anderson Symptom Inventory-Head and Neck (MDASI-HN) and Functional Assessment of Cancer TherapyHead and Neck (FACT-NH) scores, along with clinical assessment and DNA concentration of OPS. Results: There were no statistically significant differences in patients' QOL outcomes over the study period. Both groups showed an increase in symptom and interference scores, although patients in the rhDNase group showed a greater decline in both scores during the 3 months posttreatment. Similarly, both groups showed a decline in physical and functional well being but recovered in the 3 months posttreatment follow-up, with the rhDNase group exhibiting speedier recovery. Patients in the rhDNase group exhibited significant clinical improvement in OPS, blindly assessed by a physician, compared with the placebo group (67% vs 27%, respectively; P=.046). The rhDNase group showed no change in OPS-DNA concentration, although the placebo group showed a significant increase in DNA concentration during the drug trial (P=.045). There was no differences in acute toxicities between the 2 groups. Conclusions: Our preliminary data suggest that rhDNase did not significantly improve study primary endpoints of QOL measures compared with the placebo group. However, there was a significant improvement in secondary endpoints of clinically assessed OPS and DNA concentration compared with placebo in H and N cancer patients treated with CRT. Further investigation in larger numbers of patients is warranted.

  5. SU-E-T-08: A Convolution Model for Head Scatter Fluence in the Intensity Modulated Field

    SciTech Connect (OSTI)

    Chen, M; Mo, X; Chen, Y; Parnell, D; Key, S; Olivera, G; Galmarini, W; Lu, W

    2014-06-01T23:59:59.000Z

    Purpose: To efficiently calculate the head scatter fluence for an arbitrary intensity-modulated field with any source distribution using the source occlusion model. Method: The source occlusion model with focal and extra focal radiation (Jaffray et al, 1993) can be used to account for LINAC head scatter. In the model, the fluence map of any field shape at any point can be calculated via integration of the source distribution within the visible range, as confined by each segment, using the detector eye's view. A 2D integration would be required for each segment and each fluence plane point, which is time-consuming, as an intensity-modulated field contains typically tens to hundreds of segments. In this work, we prove that the superposition of the segmental integrations is equivalent to a simple convolution regardless of what the source distribution is. In fact, for each point, the detector eye's view of the field shape can be represented as a function with the origin defined at the point's pinhole reflection through the center of the collimator plane. We were thus able to reduce hundreds of source plane integration to one convolution. We calculated the fluence map for various 3D and IMRT beams and various extra-focal source distributions using both the segmental integration approach and the convolution approach and compared the computation time and fluence map results of both approaches. Results: The fluence maps calculated using the convolution approach were the same as those calculated using the segmental approach, except for rounding errors (<0.1%). While it took considerably longer time to calculate all segmental integrations, the fluence map calculation using the convolution approach took only ?1/3 of the time for typical IMRT fields with ?100 segments. Conclusions: The convolution approach for head scatter fluence calculation is fast and accurate and can be used to enhance the online process.

  6. The Residual Setup Errors of Different IGRT Alignment Procedures for Head and Neck IMRT and the Resulting Dosimetric Impact

    SciTech Connect (OSTI)

    Graff, Pierre [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States) [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States); Radiation-Oncology, Alexis Vautrin Cancer Center, Vandoeuvre-Les-Nancy (France); Doctoral School BioSE (EA4360), Nancy (France); Kirby, Neil [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States)] [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States); Weinberg, Vivian [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States) [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States); Department of Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States); Chen, Josephine; Yom, Sue S. [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States)] [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States); Lambert, Louise [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States) [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States); Radiation-Oncology, Montreal University Centre, Montreal (Canada); Pouliot, Jean, E-mail: jpouliot@radonc.ucsf.edu [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States)] [Department of Radiation-Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California (United States)

    2013-05-01T23:59:59.000Z

    Purpose: To assess residual setup errors during head and neck radiation therapy and the resulting consequences for the delivered dose for various patient alignment procedures. Methods and Materials: Megavoltage cone beam computed tomography (MVCBCT) scans from 11 head and neck patients who underwent intensity modulated radiation therapy were used to assess setup errors. Each MVCBCT scan was registered to its reference planning kVCT, with seven different alignment procedures: automatic alignment and manual registration to 6 separate bony landmarks (sphenoid, left/right maxillary sinuses, mandible, cervical 1 [C1]-C2, and C7-thoracic 1 [T1] vertebrae). Shifts in the different alignments were compared with each other to determine whether there were any statistically significant differences. Then, the dose distribution was recalculated on 3 MVCBCT images per patient for every alignment procedure. The resulting dose-volume histograms for targets and organs at risk (OARs) were compared to those from the planning kVCTs. Results: The registration procedures produced statistically significant global differences in patient alignment and actual dose distribution, calling for a need for standardization of patient positioning. Vertically, the automatic, sphenoid, and maxillary sinuses alignments mainly generated posterior shifts and resulted in mean increases in maximal dose to OARs of >3% of the planned dose. The suggested choice of C1-C2 as a reference landmark appears valid, combining both OAR sparing and target coverage. Assuming this choice, relevant margins to apply around volumes of interest at the time of planning to take into account for the relative mobility of other regions are discussed. Conclusions: Use of different alignment procedures for treating head and neck patients produced variations in patient setup and dose distribution. With concern for standardizing practice, C1-C2 reference alignment with relevant margins around planning volumes seems to be a valid option.

  7. A Phase 1 Study of Everolimus + Weekly Cisplatin + Intensity Modulated Radiation Therapy in Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Fury, Matthew G. [Department of Medicine, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Medicine, Weill Cornell Medical College, New York, New York (United States); Lee, Nancy Y. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Sherman, Eric; Ho, Alan L. [Department of Medicine, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Medicine, Weill Cornell Medical College, New York, New York (United States); Rao, Shyam [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Heguy, Adriana [Department of Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Shen, Ronglai [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Korte, Susan; Lisa, Donna [Department of Medicine, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Ganly, Ian; Patel, Snehal; Wong, Richard J.; Shaha, Ashok; Shah, Jatin [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Haque, Sofia [Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Katabi, Nora [Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Pfister, David G. [Department of Medicine, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Medicine, Weill Cornell Medical College, New York, New York (United States)

    2013-11-01T23:59:59.000Z

    Purpose: Elevated expression of eukaryotic protein synthesis initiation factor 4E (eIF4E) in histologically cancer-free margins of resected head and neck squamous cell carcinomas (HNSCCs) is mediated by mammalian target of rapamycin complex 1 (mTORC1) and has been associated with increased risk of disease recurrence. Preclinically, inhibition of mTORC1 with everolimus sensitizes cancer cells to cisplatin and radiation. Methods and Materials: This was single-institution phase 1 study to establish the maximum tolerated dose of daily everolimus given with fixed dose cisplatin (30 mg/m{sup 2} weekly 6) and concurrent intensity modulated radiation therapy for patients with locally and/or regionally advanced head-and-neck cancer. The study had a standard 3 + 3 dose-escalation design. Results: Tumor primary sites were oral cavity (4), salivary gland (4), oropharynx (2), nasopharynx (1), scalp (1), and neck node with occult primary (1). In 4 of 4 cases in which resected HNSCC surgical pathology specimens were available for immunohistochemistry, elevated expression of eIF4E was observed in the cancer-free margins. The most common grade ?3 treatment-related adverse event was lymphopenia (92%), and dose-limiting toxicities (DLTs) were mucositis (n=2) and failure to thrive (n=1). With a median follow up of 19.4 months, 2 patients have experienced recurrent disease. The maximum tolerated dose was everolimus 5 mg/day. Conclusions: Head-and-neck cancer patients tolerated everolimus at therapeutic doses (5 mg/day) given with weekly cisplatin and intensity modulated radiation therapy. The regimen merits further evaluation, especially among patients who are status post resection of HNSCCs that harbor mTORC1-mediated activation of eIF4E in histologically negative surgical margins.

  8. Dosimetric Factors Associated With Long-Term Dysphagia After Definitive Radiotherapy for Squamous Cell Carcinoma of the Head and Neck

    SciTech Connect (OSTI)

    Caudell, Jimmy J.; Schaner, Philip E. [Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL (United States); Desmond, Renee A. [Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL (United States); Meredith, Ruby F.; Spencer, Sharon A. [Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL (United States); Bonner, James A., E-mail: jabonner@uabmc.ed [Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL (United States)

    2010-02-01T23:59:59.000Z

    Purpose: Intensification of radiotherapy and chemotherapy for head-and-neck cancer may lead to increased rates of dysphagia. Dosimetric predictors of objective findings of long-term dysphagia were sought. Methods and Materials: From an institutional database, 83 patients were identified who underwent definitive intensity-modulated radiotherapy for squamous cell carcinoma of the head and neck, after exclusion of those who were treated for a second or recurrent head-and-neck primary lesion, had locoregional recurrence at any time, had less than 12 months of follow-up, or had postoperative radiotherapy. Dosimetric parameters were analyzed relative to three objective endpoints as a surrogate for severe long-term dysphagia: percutaneous endoscopic gastrostomy (PEG) tube dependence at 12 months, aspiration on modified barium swallow, or pharyngoesophageal stricture requiring dilation. Results: Mean dose greater than 41 Gy and volume receiving 60 Gy (V{sub 60}) greater than 24% to the larynx were significantly associated with PEG tube dependence and aspiration. V{sub 60} greater than 12% to the inferior pharyngeal constrictor was also significantly associated with increased PEG tube dependence and aspiration. V{sub 65} greater than 33% to the superior pharyngeal constrictor or greater than 75% to the middle pharyngeal constrictor was associated with pharyngoesophageal stricture requiring dilation. Conclusions: Doses to the larynx and pharyngeal constrictors predicted long-term swallowing complications, even when controlled for other clinical factors. The addition of these structures to intensity-modulated radiotherapy optimization may reduce the incidence of dysphagia, although cautious clinical validation is necessary.

  9. First measurement of the Head-Tail directional nuclear recoil signature at energies relevant to WIMP dark matter searches

    E-Print Network [OSTI]

    S. Burgos; E. Daw; J. Forbes; C. Ghag; M. Gold; C. Hagemann; V. A. Kudryavtsev; T. B. Lawson; D. Loomba; P. Majewski; D. Muna; A. StJ. Murphy; G. G. Nicklin; S. M. Paling; A. Petkov; S. J. S. Plank; M. Robinson; N. Sanghi; D. P. Snowden-Ifft; N. J. C. Spooner; J. Turk; E. Tziaferi

    2008-09-10T23:59:59.000Z

    We present first evidence for the so-called Head-Tail asymmetry signature of neutron-induced nuclear recoil tracks at energies down to 1.5 keV/amu using the 1m^3 DRIFT-IIc dark matter detector. This regime is appropriate for recoils induced by Weakly Interacting Massive Particle (WIMPs) but one where the differential ionization is poorly understood. We show that the distribution of recoil energies and directions induced here by Cf-252 neutrons matches well that expected from massive WIMPs. The results open a powerful new means of searching for a galactic signature from WIMPs.

  10. Clinical Management of Salivary Gland Hypofunction and Xerostomia in Head-and-Neck Cancer Patients: Successes and Barriers

    SciTech Connect (OSTI)

    Vissink, Arjan [Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Grongingen (Netherlands); Mitchell, James B. [Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD (United States); Baum, Bruce J. [Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD (United States); Limesand, Kirsten H. [Department of Nutritional Sciences, University of Arizona, Tucson, AZ (United States); Jensen, Siri Beier [Department of Oral Medicine, Institute of Odontology, Faculty of Health Sciences, University of Copenhagen, Copenhagen (Denmark); Fox, Philip C. [PC Fox Consulting, Spello (Italy); Elting, Linda S. [Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Langendijk, Johannes A. [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Coppes, Robert P. [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Department of Cell Biology, Section of Radiation and Stress Biology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Reyland, Mary E., E-mail: Mary.Reyland@UCDenver.ed [Department of Craniofacial Biology, University of Colorado Denver, Aurora, CO (United States)

    2010-11-15T23:59:59.000Z

    The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.

  11. The role of human and social capital in explaining the lack of female head coaches in women's intercollegiate sports

    E-Print Network [OSTI]

    Stumph, Kelly J

    2013-02-22T23:59:59.000Z

    likely receiving lower salaries than males. vet the 1'cmales did not report less career satisfaction (Parks et al. , 1995). There are specific factors attributed to the disparity ol' 1'emale head soccer coaches. 'I'he intrinsic measure of career success... that this salary deficit is simply a result of vvomen earning lower salaries in an array of industries not just that of coaching. For instance, it was reported that in 1995, a full-time female communications manager earned $. 86 for every $1. 00 earned bv her...

  12. Particle-in-cell simulation of the head-on collision between two ion acoustic solitary waves in plasmas

    SciTech Connect (OSTI)

    Qi, Xin; Xu, Yan-xia; Duan, Wen-shan, E-mail: duanws@nwnu.edu.cn, E-mail: lyang@impcas.ac.cn [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China and Joint Laboratory of Atomic and Molecular Physics of NWNU and IMP CAS, Northwest Normal University, Gansu, Lanzhou 730070 (China); Zhang, Ling-yu [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China and Joint Laboratory of Atomic and Molecular Physics of NWNU and IMP CAS, Northwest Normal University, Gansu, Lanzhou 730070 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Yang, Lei, E-mail: duanws@nwnu.edu.cn, E-mail: lyang@impcas.ac.cn [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China and Joint Laboratory of Atomic and Molecular Physics of NWNU and IMP CAS, Northwest Normal University, Gansu, Lanzhou 730070 (China); Department of Physics, Lanzhou University, Lanzhou 730000 (China)

    2014-08-15T23:59:59.000Z

    The head-on collision of two ion acoustic solitary waves in plasmas composed of hot electrons and cold ions has been studied by using the Poincare-Lighthill-Kuo (PLK) perturbation method and one-dimensional Particle-in-Cell (PIC) simulation. Then the phase lags of ion acoustic solitary waves (IASWs) obtained from the two approaches have been compared and discussed. It has been found that: if the amplitudes of both the colliding IASWs are small enough, the phase lags obtained from PLK method are in good agreement with those obtained from PIC simulation. As the amplitudes of IASWs increase, the phase lags from PIC simulation become smaller than the analytical ones from PLK method. Besides, the PIC simulation shows the phase lag of an IASW involved in collision depends not only on the characteristics of the wave it collides with but also on itself, which disagrees with the prediction of the PLK method. Finally, the application scopes of the PLK method in studying both the single IASW and the head-on collisions of IASWs have been studied and discussed, and the latter turns out to be more strict.

  13. High-resolution single photon planar and spect imaging of brain and neck employing a system of two co-registered opposed gamma imaging heads

    DOE Patents [OSTI]

    Majewski, Stanislaw (Yorktown, VA); Proffitt, James (Newport News, VA)

    2011-12-06T23:59:59.000Z

    A compact, mobile, dedicated SPECT brain imager that can be easily moved to the patient to provide in-situ imaging, especially when the patient cannot be moved to the Nuclear Medicine imaging center. As a result of the widespread availability of single photon labeled biomarkers, the SPECT brain imager can be used in many locations, including remote locations away from medical centers. The SPECT imager improves the detection of gamma emission from the patient's head and neck area with a large field of view. Two identical lightweight gamma imaging detector heads are mounted to a rotating gantry and precisely mechanically co-registered to each other at 180 degrees. A unique imaging algorithm combines the co-registered images from the detector heads and provides several SPECT tomographic reconstructions of the imaged object thereby improving the diagnostic quality especially in the case of imaging requiring higher spatial resolution and sensitivity at the same time.

  14. Theoretical study of head-on collision of dust acoustic solitary waves in a strongly coupled complex plasma

    SciTech Connect (OSTI)

    Jaiswal, S., E-mail: surabhi@ipr.res.in; Bandyopadhyay, P.; Sen, A. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat 382428 (India)

    2014-05-15T23:59:59.000Z

    We investigate the propagation characteristics of two counter propagating dust acoustic solitary waves (DASWs) undergoing a head-on collision, in the presence of strong coupling between micron sized charged dust particles in a complex plasma. A coupled set of nonlinear dynamical equations describing the evolution of the two DASWs using the extended Poincar-Lighthill-Kuo perturbation technique is derived. The nature and extent of post collision phase-shifts of these solitary waves are studied over a wide range of dusty plasma parameters in a strongly and a weakly coupled medium. We find a significant change in the nature and amount of phase delay in the strongly coupled regime as compared to a weakly coupled regime. The phase shift is seen to change its sign beyond a threshold value of compressibility of the medium for a given set of dusty plasma parameters.

  15. 'Pharyngocise': Randomized Controlled Trial of Preventative Exercises to Maintain Muscle Structure and Swallowing Function During Head-and-Neck Chemoradiotherapy

    SciTech Connect (OSTI)

    Carnaby-Mann, Giselle, E-mail: gmann@phhp.ufl.edu [Department of Behavioral Science and Community Health, University of Florida, Gainesville, FL (United States); Crary, Michael A. [Department of Speech Language and Hearing Sciences, University of Florida, Gainesville, FL (United States); Schmalfuss, Ilona [Department of Radiology, North Florida/South Georgia Veterans Health System, Gainesville, FL (Georgia); Amdur, Robert [Department of Radiation Oncology, University of Florida, Gainesville, FL (United States)

    2012-05-01T23:59:59.000Z

    Purpose: Dysphagia after chemoradiotherapy is common. The present randomized clinical trial studied the effectiveness of preventative behavioral intervention for dysphagia compared with the 'usual care.' Methods and Materials: A total of 58 head-and-neck cancer patients treated with chemoradiotherapy were randomly assigned to usual care, sham swallowing intervention, or active swallowing exercises (pharyngocise). The intervention arms were treated daily during chemoradiotherapy. The primary outcome measure was muscle size and composition (determined by T{sub 2}-weighted magnetic resonance imaging). The secondary outcomes included functional swallowing ability, dietary intake, chemosensory function, salivation, nutritional status, and the occurrence of dysphagia-related complications. Results: The swallowing musculature (genioglossus, hyoglossuss, and mylohyoid) demonstrated less structural deterioration in the active treatment arm. The functional swallowing, mouth opening, chemosensory acuity, and salivation rate deteriorated less in the pharyngocise group. Conclusion: Patients completing a program of swallowing exercises during cancer treatment demonstrated superior muscle maintenance and functional swallowing ability.

  16. Reduced 30% scanning time 3D multiplexer integrated circuit applied to large array format 20KHZ frequency inkjet print heads

    E-Print Network [OSTI]

    Liou, J -C

    2008-01-01T23:59:59.000Z

    Enhancement of the number and array density of nozzles within an inkjet head chip is one of the keys to raise the printing speed and printing resolutions. However, traditional 2D architecture of driving circuits can not meet the requirement for high scanning speed and low data accessing points when nozzle numbers greater than 1000. This paper proposes a novel architecture of high-selection-speed three-dimensional data registration for inkjet applications. With the configuration of three-dimensional data registration, the number of data accessing points as well as the scanning lines can be greatly reduced for large array inkjet printheads with nozzles numbering more than 1000. This IC (Integrated Circuit) architecture involves three-dimensional multiplexing with the provision of a gating transistor for each ink firing resistor, where ink firing resistors are triggered only by the selection of their associated gating transistors. Three signals: selection (S), address (A), and power supply (P), are employed toge...

  17. Impact of Adding Concomitant Chemotherapy to Hyperfractionated Accelerated Radiotherapy for Advanced Head-and-Neck Squamous Cell Carcinoma

    SciTech Connect (OSTI)

    Nuyts, Sandra [Department of Radiation Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, campus Gasthuisberg, Leuven (Belgium)], E-mail: sandra.nuyts@uzleuven.be; Dirix, Piet [Department of Radiation Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, campus Gasthuisberg, Leuven (Belgium); Clement, Paul M.J. [Department of Medical Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, campus Gasthuisberg, Leuven (Belgium); Poorten, Vincent Vander; Delaere, Pierre [Department of Otorhinolaryngology-Head and Neck Surgery, Leuvens Kankerinstituut, University Hospitals Leuven, campus Gasthuisberg, Leuven (Belgium); Schoenaers, Joseph [Department of Maxillo-Facial Surgery, Leuvens Kankerinstituut, University Hospitals Leuven, campus Gasthuisberg, Leuven (Belgium); Hermans, Robert [Department of Radiology, Leuvens Kankerinstituut, University Hospitals Leuven, campus Gasthuisberg, Leuven (Belgium); Bogaert, Walter van den [Department of Radiation Oncology, Leuvens Kankerinstituut, University Hospitals Leuven, campus Gasthuisberg, Leuven (Belgium)

    2009-03-15T23:59:59.000Z

    Purpose: To evaluate the feasibility and efficacy of a hyperfractionated accelerated radiotherapy (RT) schedule combined with concomitant chemotherapy (Cx) in patients with locally advanced head-and-neck squamous cell carcinoma. Methods and Materials: Between 2004 and 2007, a total of 90 patients with locoregionally advanced head-and-neck squamous cell carcinoma underwent irradiation according to a hybrid fractionation schedule consisting of 20 fractions of 2 Gy (once daily) followed by 20 fractions of 1.6 Gy (twice daily) to a total dose of 72 Gy. Concomitant Cx (cisplatinum 100 mg/m{sup 2}) was administered at the start of Weeks 1 and 4. Treatment outcome and toxicity were retrospectively compared with a previous patient group (n = 73) treated with the same schedule, but without concomitant Cx, between 2001 and 2004. Results: The locoregional control (LRC) rate was 70% after 2 years. Two-year overall and 2-year disease-free survival rates were 74% and 60%, respectively. In comparison with the RT-only group, an improvement of 15% in both LRC (p = 0.03) and overall survival (p = 0.09) was observed. All patients were treated to full radiation dose according to protocol, although the Cx schedule had to be adjusted in 12 patients. No acute Grade 4 or 5 toxicity was seen, but incidences of Grade 3 acute mucositis (74.5% vs. 50.7%; p = 0.002) and dysphagia (82.2% vs. 47.9%; p < 0.001) were significantly higher in the chemoradiotherapy group compared with patients treated with RT alone. Conclusion: With this chemoradiotherapy regimen, excellent LRC and survival rates were achieved, with acceptable acute toxicity.

  18. SU-E-T-149: Electron Beam Profile Differences Between Elekta MLCi2 and Elekta Agility Treatment Heads

    SciTech Connect (OSTI)

    Wu, C [Sutter Medical Foundation, Roseville, CA 95661 (United States); Hatcher, C [Sutter Shared Services S3, Sacramento, CA (United States)

    2014-06-01T23:59:59.000Z

    Purpose: To report and investigate observed differences in electron beam profiles at various energies/applicators between Elekta MLCi2 and Agility treatment head on Elekta Infinity LINAC Methods: When we upgraded from MLCi2 to Agility on one of our Elekta Infinity LINAC's, electron beam PDDs and profiles were acquired for comparison purpose. All clinical electron energies (6/9/12/15/12/18 MeV) and electron applicators (6/10/14/20/25 square) were included in measurement. PDDs were acquired at 100 SSD in water (PTW MP3 water tank) with a plane-parallel ion chamber (PTW Roos). X and Y Profiles were acquired using IC Profiler (Sun Nuclear Corp.) at 1cm and maximum PDD depths (water equivalent). Results: All PDD curves match very well between MLCi2 and Agility treatment head. However, some significant differences on electron profiles were found. On Agility, even after increasing the default auto-tracking offset values for backup diaphragms in Y and MLC in X by 2.8 cm (the maximum allowed change is 3.0 cm), electron profiles still have rounder shoulders comparing to corresponding MLCi2 profiles. This difference is significantly more pronounced at larger applicators (20 and 25 square), for all electron energies. Conclusion: The significant design change between MLCi2 and Agility beam limiting device seems to affect exit electron beam profiles. In IEC1217 X direction, the main change on Agility is the removal of the original MLCi2 X backup diaphragms and replacing it with MLC leaves; In Y direction, the main change is the radius and materials on Y backup diaphragms.

  19. Midline Dose Verification with Diode In Vivo Dosimetry for External Photon Therapy of Head and Neck and Pelvis Cancers During Initial Large-Field Treatments

    SciTech Connect (OSTI)

    Tung, Chuan-Jong [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan (China); Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan (China); Yu, Pei-Chieh [Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan (China); Department of Radiation Oncology, Cathay General Hospital, Taipei, Taiwan (China); Chiu, Min-Chi [Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan (China); Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan (China); Yeh, Chi-Yuan [Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan (China); Department of Radiation Oncology, Tungs' Taichung Metroharbor Hospital, Wuci, Taichung County, Taiwan (China); Lee, Chung-Chi [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan (China); Chao, Tsi-Chian, E-mail: chaot@mail.cgu.edu.t [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan (China)

    2010-01-01T23:59:59.000Z

    During radiotherapy treatments, quality assurance/control is essential, particularly dose delivery to patients. This study was designed to verify midline doses with diode in vivo dosimetry. Dosimetry was studied for 6-MV bilateral fields in head and neck cancer treatments and 10-MV bilateral and anteroposterior/posteroanterior (AP/PA) fields in pelvic cancer treatments. Calibrations with corrections of diodes were performed using plastic water phantoms; 190 and 100 portals were studied for head and neck and pelvis treatments, respectively. Calculations of midline doses were made using the midline transmission, arithmetic mean, and geometric mean algorithms. These midline doses were compared with the treatment planning system target doses for lateral or AP (PA) portals and paired opposed portals. For head and neck treatments, all 3 algorithms were satisfactory, although the geometric mean algorithm was less accurate and more uncertain. For pelvis treatments, the arithmetic mean algorithm seemed unacceptable, whereas the other algorithms were satisfactory. The random error was reduced by using averaged midline doses of paired opposed portals because the asymmetric effect was averaged out. Considering the simplicity of in vivo dosimetry, the arithmetic mean and geometric mean algorithm should be adopted for head/neck and pelvis treatments, respectively.

  20. Fuel Cell-Shaft Power Packs (FC-SPP) Frank Elefsen, Centre Manager, Ph.D., and Sten Frandsen, Head of Section

    E-Print Network [OSTI]

    Fuel Cell-Shaft Power Packs (FC-SPP) Frank Elefsen, Centre Manager, Ph.D., and Sten Frandsen, Head and an improved environment. 1 Fuel Cell-Shaft Power Packs (FC-SPP) A. Background In line with the growing global technology is receiving a great deal of attention. Hydrogen and fuel cells have the potential to replace

  1. Reflections on a record minimum The numbers are in 2012 broke the record for minimum sea ice extent and is still heading down (see

    E-Print Network [OSTI]

    in climate models. The approach was to freeze an icebreaker into the pack ice and drift for a year makingReflections on a record minimum The numbers are in 2012 broke the record for minimum sea ice extent and is still heading down (see Figure 1). The sea ice extent data tell an unequivocal story of ice

  2. The fork head transcription factor Hcm1p participates in the regulation of SPC110, which encodes the calmodulin-binding protein in the

    E-Print Network [OSTI]

    Davis, Trisha N.

    The fork head transcription factor Hcm1p participates in the regulation of SPC110, which encodes and abolish the ability of Hcm1p to act as a suppressor of calmodulin mutants. The promoter of SPC110 contains a match to the consensus binding site. Deletion of HCM1 does not affect the basal level of SPC110

  3. Evaluation of advanced turbomachinery for underground pumped hydroelectric storage. Part 3. Multistage unregulated pump/turbines for operating heads of 1000 to 1500 m

    SciTech Connect (OSTI)

    Frigo, A.A.; Pistner, C.

    1980-08-01T23:59:59.000Z

    This is the final report in a series of three on studies of advanced hydraulic turbomachinery for underground pumped hydroelectric storage. All three reports address Francis-type, reversible pump/turbines. The first report covered single-stage regulated units; the second report covered two-stage regulated units; the present report covers multistage unregulated units. Multistage unregulated pump/turbines offer an economically attractive option for heads of 1000 to 1500 m. The feasibility of developing such machines for capacities up to 500 MW and operating heads up to 1500 m has been evaluated. Preliminary designs have been generated for six multistage pump/turbines. The designs are for nominal capacities of 350 and 500 MW and for operating heads of 1000, 1250, and 1500 m. Mechanical, hydraulic, and economic analyses indicate that these machines will behave according to the criteria used to design them and that they can be built at a reasonable cost with no unsolvable problems. Efficiencies of 85.8% and 88.5% in the generating and pumping modes, respectively, can be expected for the 500-MW, 1500-m unit. Performances of the other five machines are at least comparable, and usually better. Over a 1000 to 1500-m head range, specific $/kW costs of the pump/turbines in mid-1978 US dollars vary from 19.0 to 23.1 for the 500-MW machines, and from 21.0 to 24.1 for the 350-MW machines.

  4. Normal Tissue Complication Probability Modeling of Radiation-Induced Hypothyroidism After Head-and-Neck Radiation Therapy

    SciTech Connect (OSTI)

    Bakhshandeh, Mohsen [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)] [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Hashemi, Bijan, E-mail: bhashemi@modares.ac.ir [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)] [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Mahdavi, Seied Rabi Mehdi [Department of Medical Physics, Faculty of Medical Sciences, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of)] [Department of Medical Physics, Faculty of Medical Sciences, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Nikoofar, Alireza; Vasheghani, Maryam [Department of Radiation Oncology, Hafte-Tir Hospital, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of)] [Department of Radiation Oncology, Hafte-Tir Hospital, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Kazemnejad, Anoshirvan [Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)] [Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)

    2013-02-01T23:59:59.000Z

    Purpose: To determine the dose-response relationship of the thyroid for radiation-induced hypothyroidism in head-and-neck radiation therapy, according to 6 normal tissue complication probability models, and to find the best-fit parameters of the models. Methods and Materials: Sixty-five patients treated with primary or postoperative radiation therapy for various cancers in the head-and-neck region were prospectively evaluated. Patient serum samples (tri-iodothyronine, thyroxine, thyroid-stimulating hormone [TSH], free tri-iodothyronine, and free thyroxine) were measured before and at regular time intervals until 1 year after the completion of radiation therapy. Dose-volume histograms (DVHs) of the patients' thyroid gland were derived from their computed tomography (CT)-based treatment planning data. Hypothyroidism was defined as increased TSH (subclinical hypothyroidism) or increased TSH in combination with decreased free thyroxine and thyroxine (clinical hypothyroidism). Thyroid DVHs were converted to 2 Gy/fraction equivalent doses using the linear-quadratic formula with {alpha}/{beta} = 3 Gy. The evaluated models included the following: Lyman with the DVH reduced to the equivalent uniform dose (EUD), known as LEUD; Logit-EUD; mean dose; relative seriality; individual critical volume; and population critical volume models. The parameters of the models were obtained by fitting the patients' data using a maximum likelihood analysis method. The goodness of fit of the models was determined by the 2-sample Kolmogorov-Smirnov test. Ranking of the models was made according to Akaike's information criterion. Results: Twenty-nine patients (44.6%) experienced hypothyroidism. None of the models was rejected according to the evaluation of the goodness of fit. The mean dose model was ranked as the best model on the basis of its Akaike's information criterion value. The D{sub 50} estimated from the models was approximately 44 Gy. Conclusions: The implemented normal tissue complication probability models showed a parallel architecture for the thyroid. The mean dose model can be used as the best model to describe the dose-response relationship for hypothyroidism complication.

  5. A Space Weather Information Service Based Upon Remote and In-Situ Measurements of Coronal Mass Ejections Heading for Earth

    E-Print Network [OSTI]

    Ritter, Birgit; Miles, Oscar; Ruwurm, Michael; Scully, Stephen; Roldn, Andrs; Hartkorn, Oliver; Jstel, Peter; Rville, Victor; Lupu, Sorina; Ruffenach, Alexis

    2015-01-01T23:59:59.000Z

    The Earth's magnetosphere is formed as a consequence of interaction between the planet's magnetic field and the solar wind, a continuous plasma stream from the Sun. A number of different solar wind phenomena have been studied over the past forty years with the intention of understanding and forecasting solar behavior. One of these phenomena in particular, Earth-bound interplanetary coronal mass ejections (CMEs), can significantly disturb the Earth's magnetosphere for a short time and cause geomagnetic storms. This publication presents a mission concept consisting of six spacecraft that are equally spaced in a heliocentric orbit at 0.72 AU. These spacecraft will monitor the plasma properties, the magnetic field's orientation and magnitude, and the 3D-propagation trajectory of CMEs heading for Earth. The primary objective of this mission is to increase space weather (SW) forecasting time by means of a near real-time information service, that is based upon in-situ and remote measurements of the aforementioned CM...

  6. Enteral Feeding Tubes in Patients Undergoing Definitive Chemoradiation Therapy for Head-and-Neck Cancer: A Critical Review

    SciTech Connect (OSTI)

    Koyfman, Shlomo A., E-mail: koyfmas@ccf.org [Departments of Radiation and Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (United States); Adelstein, David J. [Departments of Radiation and Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (United States)] [Departments of Radiation and Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (United States)

    2012-11-01T23:59:59.000Z

    Definitive chemoradiation therapy has evolved as the preferred organ preservation strategy in the treatment of locally advanced head-and-neck cancer (LA-HNC). Dry mouth and dysphagia are among the most common and most debilitating treatment-related toxicities that frequently necessitate the placement of enteral feeding tubes (FT) in these patients to help them meet their nutritional requirements. The use of either a percutaneous endoscopic gastrostomy tube or a nasogastric tube, the choice of using a prophylactic vs a reactive approach, and the effects of FTs on weight loss, hospitalization, quality of life, and long-term functional outcomes are areas of continued controversy. Considerable variations in practice patterns exist in the United States and abroad. This critical review synthesizes the current data for the use of enteral FTs in this patient population and clarifies the relative advantages of different types of FTs and the timing of their use. Recent developments in the biologic understanding and treatment approaches for LA-HNC appear to be favorably impacting the frequency and severity of treatment-related dysphagia and may reduce the need for enteral tube feeding in the future.

  7. Role of Positron Emission Tomography in the Treatment of Occult Disease in Head-and-Neck Cancer: A Modeling Approach

    SciTech Connect (OSTI)

    Phillips, Mark H., E-mail: markp@u.washington.ed [Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA (United States); Smith, Wade P. [Department of Veterans Affairs, Albany, NY (United States); Parvathaneni, Upendra; Laramore, George E. [Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA (United States)

    2011-03-15T23:59:59.000Z

    Purpose: To determine under what conditions positron emission tomography (PET) imaging will be useful in decisions regarding the use of radiotherapy for the treatment of clinically occult lymph node metastases in head-and-neck cancer. Methods and Materials: A decision model of PET imaging and its downstream effects on radiotherapy outcomes was constructed using an influence diagram. This model included the sensitivity and specificity of PET, as well as the type and stage of the primary tumor. These parameters were varied to determine the optimal strategy for imaging and therapy for different clinical situations. Maximum expected utility was the metric by which different actions were ranked. Results: For primary tumors with a low probability of lymph node metastases, the sensitivity of PET should be maximized, and 50 Gy should be delivered if PET is positive and 0 Gy if negative. As the probability for lymph node metastases increases, PET imaging becomes unnecessary in some situations, and the optimal dose to the lymph nodes increases. The model needed to include the causes of certain health states to predict current clinical practice. Conclusion: The model demonstrated the ability to reproduce expected outcomes for a range of tumors and provided recommendations for different clinical situations. The differences between the optimal policies and current clinical practice are likely due to a disparity between stated clinical decision processes and actual decision making by clinicians.

  8. Sperm-head morphology study in B6C3F1 mice following inhalation exposure to 1,3-butadiene: Final technical report

    SciTech Connect (OSTI)

    Hackett, P.L.; McClanahan, B.J.; Brown, M.G.; Buschbom, R.L.; Clark, M.L.; Decker, J.R.; Evanoff, J.J.; Rommereim, R.L.; Rowe, S.E.; Westerberg, R.B.

    1988-04-01T23:59:59.000Z

    The present report describes the results of a study of the morphology of epididymal sperm heads of B6C3F1 mice that were exposed to varying concentrations of 1,3-butadiene. During the fifth post-exposure week, the animals were killed and examined for gross lesions of the reproductive tract; suspensions of the epididymal sperm were prepared for morphologic evaluations. No mortality was observed in any of the inhalation exposure groups. Transient toxic signs, including piloerection and dyspnea, were evident during a 20- to 30-minute period following exposure to 5000 ppM. Mean values for body weights and weight gains of the mice exposed to 1,3-butadiene were not significantly different from control values. A concentration-related increase in the incidence of sperm-head abnormalities was evident and the percentage of sperm heads that were morphologically abnormal was significantly higher in mice exposed to 1000 and 5000 ppM than in the controls. 23 refs., 2 figs., 6 tabs.

  9. Specific recommendations for accurate and direct use of PET-CT in PET guided radiotherapy for head and neck sites

    SciTech Connect (OSTI)

    Thomas, C. M., E-mail: christopher.thomas@gstt.nhs.uk; Convery, D. J.; Greener, A. G. [Guy's and St. Thomas NHS Foundation Trust, Medical Physics Department, St. Thomas Hospital, London SE1 7EH (United Kingdom)] [Guy's and St. Thomas NHS Foundation Trust, Medical Physics Department, St. Thomas Hospital, London SE1 7EH (United Kingdom); Pike, L. C.; Baker, S.; Woods, E. [Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas Hospital, London SE1 7EH (United Kingdom)] [Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas Hospital, London SE1 7EH (United Kingdom); Hartill, C. E. [Guy's and St. Thomas NHS Foundation Trust, Radiotherapy, Clinical Outpatients Clinic, St. Thomas Hospital, London SE1 7EH (United Kingdom)] [Guy's and St. Thomas NHS Foundation Trust, Radiotherapy, Clinical Outpatients Clinic, St. Thomas Hospital, London SE1 7EH (United Kingdom)

    2014-04-15T23:59:59.000Z

    Purpose: To provide specific experience-based guidance and recommendations for centers wishing to develop, validate, and implement an accurate and efficient process for directly using positron emission tomography-computed tomography (PET-CT) for the radiotherapy planning of head and neck cancer patients. Methods: A PET-CT system was modified with hard-top couch, external lasers and radiotherapy immobilization and indexing devices and was subject to a commissioning and quality assurance program. PET-CT imaging protocols were developed specifically for radiotherapy planning and the image quality and pathway tested using phantoms and five patients recruited into an in-house study. Security and accuracy of data transfer was tested throughout the whole data pathway. The patient pathway was fully established and tested ready for implementation in a PET-guided dose-escalation trial for head and neck cancer patients. Results: Couch deflection was greater than for departmental CT simulator machines. An area of high attenuation in the couch generated image artifacts and adjustments were made accordingly. Using newly developed protocols CT image quality was suitable to maintain delineation and treatment accuracy. Upon transfer of data to the treatment planning system a half pixel offset between PET and CT was observed and corrected. By taking this into account, PET to CT alignment accuracy was maintained below 1 mm in all systems in the data pathway. Transfer of structures delineated in the PET fusion software to the radiotherapy treatment planning system was validated. Conclusions: A method to perform direct PET-guided radiotherapy planning was successfully validated and specific recommendations were developed to assist other centers. Of major concern is ensuring that the quality of PET and CT data is appropriate for radiotherapy treatment planning and on-treatment verification. Couch movements can be compromised, bore-size can be a limitation for certain immobilization techniques, laser positioning may affect setup accuracy and couch deflection may be greater than scanners dedicated to radiotherapy. The full set of departmental commissioning and routine quality assurance tests applied to radiotherapy CT simulators must be carried out on the PET-CT scanner. CT image quality must be optimized for radiotherapy planning whilst understanding that the appearance will differ between scanners and may affect delineation. PET-CT quality assurance schedules will need to be added to and modified to incorporate radiotherapy quality assurance. Methods of working for radiotherapy and PET staff will change to take into account considerations of both parties. PET to CT alignment must be subject to quality control on a loaded and unloaded couch preferably using a suitable emission phantom, and tested throughout the whole data pathway. Data integrity must be tested throughout the whole pathway and a system included to verify that delineated structures are transferred correctly. Excellent multidisciplinary team communication and working is vital, and key staff members on both sides should be specifically dedicated to the project. Patient pathway should be clearly devised to optimize patient care and the resources of all departments. Recruitment of a cohort of patients into a methodology study is valuable to test the quality assurance methods and pathway.

  10. Efficacy and Toxicity of Chemoradiotherapy Using Intensity-Modulated Radiotherapy for Unknown Primary of Head and Neck

    SciTech Connect (OSTI)

    Sher, David J., E-mail: dsher@lroc.harvard.edu [Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA (United States); Balboni, Tracy A. [Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA (United States); Haddad, Robert I. [Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (United States); Department of Medicine, Brigham and Women's Hospital, Boston, MA (United States); Norris, Charles M. [Department of Surgery, Division of Otolaryngology, Brigham and Women's Hospital, Boston, MA (United States); Posner, Marshall R. [Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (United States); Department of Medicine, Brigham and Women's Hospital, Boston, MA (United States); Wirth, Lori J. [Department of Medical Oncology, Massachusetts General Hospital, Boston, MA (United States); Goguen, Laura A.; Annino, Donald [Department of Surgery, Division of Otolaryngology, Brigham and Women's Hospital, Boston, MA (United States); Tishler, Roy B. [Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA (United States)

    2011-08-01T23:59:59.000Z

    Purpose: No single standard treatment paradigm is available for head-and-neck squamous cell carcinoma of an unknown primary (HNCUP). Bilateral neck radiotherapy with mucosal axis irradiation is widely used, with or without chemotherapy and/or surgical resection. Intensity-modulated radiotherapy (IMRT) is a highly conformal method for delivering radiation that is becoming the standard of care and might reduce the long-term treatment-related sequelae. We report the Dana-Farber Cancer Institute experience with IMRT-based treatment for HNCUP. Patients and Materials: A retrospective study of all patients treated at the Dana-Farber Cancer Institute for HNCUP with IMRT between August 2004 and January 2009. The primary endpoint was overall survival; the secondary endpoints were locoregional and distant control, and acute and chronic toxicity. Results: A total of 24 patients with HNCUP were included. Of these patients, 22 had Stage N2 disease or greater. All patients underwent neck computed tomography, positron emission tomography-computed tomography, and examination under anesthesia with directed biopsies. Of the 24 patients, 22 received concurrent chemotherapy, and 7 (29%) also underwent induction chemotherapy. The median involved nodal dose was 70 Gy, and the median mucosal dose was 60 Gy. With a median follow-up of 2.1 years, the 2-year actuarial overall survival and locoregional control rate was 92% and 100%, respectively. Only 25% of the patients had Grade 2 xerostomia, although 11 patients (46%) required esophageal dilation for stricture. Conclusion: In a single-institution series, IMRT-based chemoradiotherapy for HNCUP was associated with superb overall survival and locoregional control. The xerostomia rates were promising, but the aggressive therapy was associated with significant rates of esophageal stenosis.

  11. Phenylbutyrate Mouthwash Mitigates Oral Mucositis During Radiotherapy or Chemoradiotherapy in Patients With Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Yen, Sang-Hue; Wang, Ling-Wei [Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan (China); National Yang Ming University, School of Medicine, Taipei, Taiwan (China); Lin, Yi-Hsien [Division of Radiotherapy, Cheng Hsin General Hospital, Taipei, Taiwan (China); Jen, Yee-Min, E-mail: yeeminjen@yahoo.com.tw [Department of Radiation Oncology, Tri-Service General Hospital, Taipei, Taiwan (China); National Defense Medical Center, Taipei, Taiwan (China); Chung, Yih-Lin, E-mail: ylchung@kfsyscc.org [Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China); National Yang Ming University, School of Medicine, Taipei, Taiwan (China)

    2012-03-15T23:59:59.000Z

    Purpose: Deleterious oral mucositis (OM) develops during radiotherapy (RT) or chemoradiotherapy for head-and-neck cancer (HNC) patients. There are currently no effective cytoprotective treatments for OM without a potential risk of tumor protection. This randomized, double-blind, placebo-controlled pilot study aimed to determine the therapeutic safety and efficacy of phenylbutyrate (an antitumor histone deacetylase inhibitor and chemical chaperone) 5% mouthwash for treating OM caused by cancer therapy. Methods and Materials: Between September 2005 and June 2006, 36 HNC patients were randomized to standard oral care plus 5 mL of either phenylbutyrate 5% mouthwash (n = 17) or placebo (mouthwash vehicle, n = 19) taken four times daily (swish and spit). Treatment began when mild mucositis (Radiation Therapy Oncology Group Grade 1) occurred, and ended 4 weeks after RT completion. Safety and efficacy were based on adverse events, physical examination, laboratory determinations, vital signs, Oral Mucosa Assessment Scale (OMAS) and World Health Organization scores, the ability to eat, body weight change, local control, and survival. Results: We found no severe drug-related side effect. At RT doses of 5500-7500 cGy, phenylbutyrate significantly mitigated the severity of mucositis compared with placebo, based on both the WHO score (severity {>=} 3; p = 0.0262) and the OMAS scale (ulceration score {>=} 2; p = 0.0049). The Kaplan-Meier estimates for 2- and 3-year local control, and overall survival were 100% and 80.8%, and 78.6% and 64.3%, respectively, in the phenylbutyrate group and 74.2% and 74.2%, and 57.4% and 50.2%, respectively, in the placebo group. Conclusions: This pilot trial suggested that phenylbutyrate mouthwash significantly decreased the impact of OM in HNC patients receiving RT or chemoradiotherapy and did not confront the tumor control. Larger Phase II randomized trials are needed to confirm these results.

  12. Investigation of Pitch and Jaw Width to Decrease Delivery Time of Helical Tomotherapy Treatments for Head and Neck Cancer

    SciTech Connect (OSTI)

    Moldovan, Monica [Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States); Fontenot, Jonas D., E-mail: jfontenot@marybird.com [Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States); Gibbons, John P. [Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States); Department of Physics and Astronomy, Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA (United States); Lee, Tae Kyu [Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States); Rosen, Isaac I. [Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States); Department of Physics and Astronomy, Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA (United States); Fields, Robert S. [Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States); Hogstrom, Kenneth R. [Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States); Department of Physics and Astronomy, Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA (United States)

    2011-01-01T23:59:59.000Z

    Helical tomotherapy plans using a combination of pitch and jaw width settings were developed for 3 patients previously treated for head and neck cancer. Three jaw widths (5, 2.5, and 1 cm) and 4 pitches (0.86, 0.43, 0.287, and 0.215) were used with a (maximum) modulation factor setting of 4. Twelve plans were generated for each patient using an identical optimization procedure (e.g., number of iterations, objective weights, and penalties, etc.), based on recommendations from TomoTherapy (Madison, WI). The plans were compared using isodose plots, dose volume histograms, dose homogeneity indexes, conformity indexes, radiobiological models, and treatment times. Smaller pitches and jaw widths showed better target dose homogeneity and sparing of normal tissue, as expected. However, the treatment time increased inversely proportional to the jaw width, resulting in delivery times of 24 {+-} 1.9 min for the 1-cm jaw width. Although treatment plans produced with the 2.5-cm jaw were dosimetrically superior to plans produced with the 5-cm jaw, subsequent calculations of tumor control probabilities and normal tissue complication probabilities suggest that these differences may not be radiobiologically meaningful. Because treatment plans produced with the 5-cm jaw can be delivered in approximately half the time of plans produced with the 2.5-cm jaw (5.1 {+-} 0.6 min vs. 9.5 {+-} 1.1 min), use of the 5-cm jaw in routine treatment planning may be a viable approach to decreasing treatment delivery times from helical tomotherapy units.

  13. Real-Time In Vivo Dosimetry With MOSFET Detectors in Serial Tomotherapy for Head and Neck Cancer Patients

    SciTech Connect (OSTI)

    Qi Zhenyu [Department of Radiation Oncology, Sun Yat-Sen University Cancer Center and State Key Laboratory of Oncology in Southern China, Guangzhou 510060 (China); Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales 2522 (Australia); Deng Xiaowu, E-mail: dengxw@mail.sysu.edu.cn [Department of Radiation Oncology, Sun Yat-Sen University Cancer Center and State Key Laboratory of Oncology in Southern China, Guangzhou 510060 (China); Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales 2522 (Australia); Huang Shaomin [Department of Radiation Oncology, Sun Yat-Sen University Cancer Center and State Key Laboratory of Oncology in Southern China, Guangzhou 510060 (China); Shiu, Almon [Radiation Physics Department, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 (United States); Lerch, Michael; Metcalfe, Peter; Rosenfeld, Anatoly [Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales 2522 (Australia); Kron, Tomas [Peter MacCallum Cancer Centre, Melbourne VIC 3002 (Australia)

    2011-08-01T23:59:59.000Z

    Purpose: A real-time dose verification method using a recently designed metal oxide semiconductor field effect transistor (MOSFET) dosimetry system was evaluated for quality assurance (QA) of intensity-modulated radiation therapy (IMRT). Methods and Materials: Following the investigation of key parameters that might affect the accuracy of MOSFET measurements (i.e., source surface distance [SSD], field size, beam incident angles and radiation energy spectrum), the feasibility of this detector in IMRT dose verification was demonstrated by comparison with ion chamber measurements taken in an IMRT QA phantom. Real-time in vivo measurements were also performed with the MOSFET system during serial tomotherapy treatments administered to 8 head and neck cancer patients. Results: MOSFET sensitivity did not change with SSD. For field sizes smaller than 20 x 20 cm{sup 2}, MOFET sensitivity varied within 1.0%. The detector angular response was isotropic within 2% over 360{sup o}, and the observed sensitivity variation due to changes in the energy spectrum was negligible in 6-MV photons. MOSFET system measurements and ion chamber measurements agreed at all points in IMRT phantom plan verification, within 5%. The mean difference between 48 IMRT MOSFET-measured doses and calculated values in 8 patients was 3.33% and ranged from -2.20% to 7.89%. More than 90% of the total measurements had deviations of less than 5% from the planned doses. Conclusion: The MOSFET dosimetry system has been proven to be an effective tool in evaluating the actual dose within individual patients during IMRT treatment.

  14. Predictors of IMRT and Conformal Radiotherapy Use in Head and Neck Squamous Cell Carcinoma: A SEER-Medicare Analysis

    SciTech Connect (OSTI)

    Sher, David J., E-mail: dsher@lroc.harvard.edu [Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA (United States); Center for Outcomes and Policy Research, Dana Farber Cancer Institute, Boston, MA (United States); Neville, Bridget A. [Center for Outcomes and Policy Research, Dana Farber Cancer Institute, Boston, MA (United States); Chen, Aileen B. [Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA (United States); Center for Outcomes and Policy Research, Dana Farber Cancer Institute, Boston, MA (United States); Schrag, Deborah [Center for Outcomes and Policy Research, Dana Farber Cancer Institute, Boston, MA (United States)

    2011-11-15T23:59:59.000Z

    Purpose: The extent to which new techniques for the delivery of radiotherapy for head and neck squamous cell carcinoma (HNSCC) have diffused into clinical practice is unclear, including the use of 3-dimensional conformal RT (3D-RT) and intensity-modulated radiation therapy (IMRT). Methods and Materials: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database, we identified 2,495 Medicare patients with Stage I-IVB HNSCC diagnosed at age 65 years or older between 2000 and 2005 and treated with either definitive (80%) or adjuvant (20%) radiotherapy. Our primary aim was to analyze the trends and predictors of IMRT use over this time, and the secondary aim was a similar description of the trends and predictors of conformal radiotherapy (CRT) use, defined as treatment with either 3D-RT or IMRT. Results: Three hundred sixty-four (15%) patients were treated with IMRT, and 1,190 patients (48%) were treated with 3D-RT. Claims for IMRT and CRT rose from 0% to 33% and 39% to 86%, respectively, between 2000 and 2005. On multivariable analysis, IMRT use was associated with SEER region (West 18%; Northeast 11%; South 12%; Midwest 13%), advanced stage (advanced, 21%; early, 9%), non-larynx site (non-larynx, 23%; larynx, 7%), higher median census tract income (highest vs. lowest quartile, 18% vs. 10%), treatment year (2003-2005, 31%; 2000-2002, 6%), use of chemotherapy (26% with; 9% without), and higher radiation oncologist treatment volume (highest vs. lowest tertile, 23% vs. 8%). With CRT as the outcome, only SEER region, treatment year, use of chemotherapy, and increasing radiation oncologist HNSCC volume were significant on multivariable analysis. Conclusions: The use of IMRT and CRT by Medicare beneficiaries with HNSCC rose significantly between 2000 and 2005 and was associated with both clinical and non-clinical factors, with treatment era and radiation oncologist HNSCC treatment volume serving as the strongest predictors of IMRT use.

  15. Observational Study Designs for Comparative Effectiveness Research: An Alternative Approach to Close Evidence Gaps in Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Goulart, Bernardo H.L., E-mail: bhg@uw.edu [Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Hutchinson Institute for Cancer Outcomes Research (HICOR), Seattle, Washington (United States); University of Washington, Seattle, Washington (United States); Ramsey, Scott D. [Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Hutchinson Institute for Cancer Outcomes Research (HICOR), Seattle, Washington (United States); University of Washington, Seattle, Washington (United States); Parvathaneni, Upendra [Department of Radiation Oncology, University of Washington, Seattle, Washington (United States); University of Washington, Seattle, Washington (United States)

    2014-01-01T23:59:59.000Z

    Comparative effectiveness research (CER) has emerged as an approach to improve quality of care and patient outcomes while reducing healthcare costs by providing evidence to guide healthcare decisions. Randomized controlled trials (RCTs) have represented the ideal study design to support treatment decisions in head-and-neck (H and N) cancers. In RCTs, formal chance (randomization) determines treatment allocation, which prevents selection bias from distorting the measure of treatment effects. Despite this advantage, only a minority of patients qualify for inclusion in H and N RCTs, which limits the validity of their results to the broader H and N cancer patient population seen in clinical practice. Randomized controlled trials often do not address other knowledge gaps in the management of H and N cancer, including treatment comparisons for rare types of H and N cancers, monitoring of rare or late toxicity events (eg, osteoradionecrosis), or in some instances an RCT is simply not feasible. Observational studies, or studies in which treatment allocation occurs independently of investigators' choice or randomization, may address several of these gaps in knowledge, thereby complementing the role of RCTs. This critical review discusses how observational CER studies complement RCTs in generating the evidence to inform healthcare decisions and improve the quality of care and outcomes of H and N cancer patients. Review topics include a balanced discussion about the strengths and limitations of both RCT and observational CER study designs; a brief description of design and analytic techniques to handle selection bias in observational studies; examples of observational studies that inform current clinical practices and management of H and N cancers; and suggestions for relevant CER questions that could be addressed by an observational study design.

  16. SU-E-J-245: Is Off-Line Adaptive Radiotherapy Sufficient for Head and Neck Cancer with IGRT?

    SciTech Connect (OSTI)

    Li, Z [the 6th People's Hospital of Shanghai Jiaotong University, Shanghai, Shanghai (China); Cleveland Clinic, Cleveland, OH (United States); Shang, Q; Liu, H; Greskovich, J; Koyfman, S; Xia, P [Cleveland Clinic, Cleveland, OH (United States)

    2014-06-01T23:59:59.000Z

    Purpose: Radiation doses delivered to patients with head and neck cancer (HN) may deviate from the planned doses because of variations in patient setup and anatomy. This study was to evaluate whether off-line Adaptive Radiotherapy (ART) is sufficient. Methods: Ten HN patients, who received IMRT under daily imaging guidance using CT-on-rail/KV-CBCT, were randomly selected for this study. For each patient, the daily treatment setup was corrected with translational only directions. Sixty weekly verification CTs were retrospectively analyzed. On these weekly verification CTs, the tumor volumes and OAR contours were manually delineated by a physician. With the treatment iso-center placed on the verification CTs, according to the recorded clinical shifts, the treatment beams from the original IMRT plans were then applied to these CTs to calculate the delivered doses. The electron density of the planning CTs and weekly CTs were overridden to 1 g/cm3. Results: Among 60 fractions, D99 of the CTVs in 4 fractions decreased more than 5% of the planned doses. The maximum dose of the spinal cord exceeded 10% of the planned values in 2 fractions. A close examination indicated that the dose discrepancy in these 6 fractions was due to patient rotations, especially shoulder rotations. After registering these 6 CTs with the planning CT allowing six degree of freedoms, the maximum rotations around 3 axes were > 1.5 for these fractions. With rotation setup errors removed, 4 out of 10 patients still required off-line ART to accommodate anatomical changes. Conclusion: A significant shoulder rotations were observed in 10% fractions, requiring patient re-setup. Off-line ART alone is not sufficient to correct for random variations of patient position, although ART is effective to adapt to patients' gradual anatomic changes. Re-setup or on-line ART may be considered for patients with large deviations detected early by daily IGRT images. The study is supported in part by Siemens Medical Solutions.

  17. Correlating Computed Tomography Perfusion Changes in the Pharyngeal Constrictor Muscles During Head-and-Neck Radiotherapy to Dysphagia Outcome

    SciTech Connect (OSTI)

    Truong, Minh Tam, E-mail: mitruong@bu.edu [Department of Radiation Oncology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Department of Radiology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Lee, Richard [Department of Radiation Oncology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Saito, Naoko [Department of Radiology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Qureshi, Muhammad M. [Department of Radiation Oncology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Ozonoff, Al [Department of Biostatistics, Boston University School of Public Health, Boston, MA (United States); Romesser, Paul B. [Department of Radiation Oncology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Wang, Jimmy; Sakai, Osamu [Department of Radiology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States)

    2012-02-01T23:59:59.000Z

    Purpose: To measure changes in perfusion of the pharyngeal constrictor muscles (PCM) using CT perfusion (CTP) imaging during a course of definitive radiotherapy (RT) in head-and-neck cancer (HNC) patients and correlate with dysphagia outcome after RT. Methods and Materials: Fifteen HNC patients underwent CTP imaging of the PCM at baseline and Weeks 2, 4, and 6 during RT and 6 weeks after RT. Blood flow and blood volume were measured in the PCM, and percentage change from baseline scan was determined. A single physician-based assessment of dysphagia was performed every 3 months after RT using the Common Terminology Criteria for Adverse Events, version 3.0 grading system. Results: With a median follow-up of 28 months (range, 6-44 months), Grade 3 dysphagia was present in 7 of 15 patients, and 8 patients experienced Grade 0-2 dysphagia. The CTP parameters at Week 2 of RT demonstrated an increase in mean PCM blood flow of 161.9% vs. 12.3% (p = 0.007) and an increase in mean PCM blood volume of 96.6% vs. 8.7% (p = 0.039) in patients with 6-month post-RT Grade 3 dysphagia and Grade 0-2 dysphagia, respectively. On multivariate analysis, when adjusting for smoking history, tumor volume, and baseline dysphagia status, an increase in blood flow in the second week of RT was significant for 3- and 6-month Grade 3 dysphagia (p < 0.05). Conclusions: Perfusion changes in the PCM during Week 2 of RT in the PCM may predict the severity of dysphagia after HNC RT.

  18. Heads and Tails

    E-Print Network [OSTI]

    Glasgow, M.F.

    1999-01-01T23:59:59.000Z

    . www.oblique-publications.net Oblique Publications? library of zines will be available for free download in PDF format from its website. Beginning 1999 j j j Succor Skintone Beacon in the Night A View from the Top Saving Walter S. Foxhole... years, but we have almost never posted stories to lists or put them up in HTML format on anyone?s website. We are resistors. Controlling look and protect- ing content are serious issues with us. We?ve finally decided to make the transition to the web...

  19. from the Head

    E-Print Network [OSTI]

    Sally Goeke

    2010-06-30T23:59:59.000Z

    Feb 24, 2010 ... of science, engineering, and technology and in helping all students develop critical thinking skills that are transferable to their future pursuits, ..... physics in the Freshman Summer Institute (FSI) at Caltech; and led a research...

  20. from the Head

    E-Print Network [OSTI]

    Sally Goeke

    2010-06-30T23:59:59.000Z

    2. The College of Science honored distinguished alumni at a banquet on .... Cushman's research interests include fluids in porous media, stochastic processes,.

  1. from the Head

    E-Print Network [OSTI]

    Sally Goeke

    2009-07-14T23:59:59.000Z

    Dublin, Ohio with their son, Jack, and daughter, Lauren. Dan Rubin .... Spring: Andrew Bohn, Michael Burkhart, ... to present the Gerald R. MacLane award in...

  2. Comparison of Four Cisplatin-Based Radiochemotherapy Regimens for Nonmetastatic Stage III/IV Squamous Cell Carcinoma of the Head and Neck;Head-and-neck cancer; Cisplatin-based radiochemotherapy; Toxicity; Treatment outcomes

    SciTech Connect (OSTI)

    Rades, Dirk, E-mail: Rades.Dirk@gmx.net [Department of Radiation Oncology, University of Lubeck, Lubeck (Germany); Kronemann, Stefanie; Meyners, Thekla; Bohlen, Guenther [Department of Radiation Oncology, University of Lubeck, Lubeck (Germany); Tribius, Silke [Department of Radiation Oncology, University of Hamburg, Hamburg (Germany); Kazic, Nadja [Department of Radiation Oncology, University of Sarajevo, Sarajevo (Bosnia and Herzegowina); Schroeder, Ursula [Department of Head and Neck Surgery, University of Lubeck, Lubeck (Germany); Hakim, Samer G. [Department of Maxillofacial Surgery, University of Lubeck, Lubeck (Germany); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AR (United States); Dunst, Juergen [Department of Radiation Oncology, University of Lubeck, Lubeck (Germany)

    2011-07-15T23:59:59.000Z

    Purpose: To compare the outcomes of four cisplatin-based radiochemotherapy regimens in 311 patients with Stage III/IV squamous cell carcinoma of the head and neck. Methods and Materials: Concurrent chemotherapy consisted of three courses of cisplatin 100 mg/m{sup 2} on Day 1 (Group A, n = 74), two courses of cisplatin 20 mg/m{sup 2} on Days 1-5 plus 5-fluorouracil 1,000 mg/m{sup 2} on Days 1-5 (Group B, n = 49), two courses of cisplatin 20 mg/m{sup 2} on Days 1-5 plus 5-fluorouracil 600 mg/m{sup 2} on Days 1-5 (Group C, n = 102), or two courses of cisplatin 20 mg/m{sup 2} on Days 1-5 (Group D, n = 86). The groups were retrospectively compared for toxicity and outcomes, and 11 additional factors were evaluated for outcomes. Results: No significant difference was observed among the groups regarding radiation-related acute oral mucositis and radiation-related late toxicities. Acute Grade 3 skin toxicity was significantly more frequent in Group B than in the patients of the other three groups (p = .013). The chemotherapy-related Grade 3 nausea/vomiting rate was 24% for Group A, 8% for Group B, 9% for Group C, and 6% for Group D (p = .003). The corresponding Grade 3 nephrotoxicity rates were 8%, 1%, 2%, and 1% (p = .019). The corresponding Grade 3-4 hematologic toxicity rates were 35%, 41%, 19%, and 21% (p = .027). Chemotherapy could be completed in 50%, 59%, 74%, and 83% of the Group A, B, C, and D patients, respectively (p = .002). Toxicity-related radiotherapy breaks occurred in 39%, 43%, 21%, and 15% of Groups A, B, C, and D, respectively (p = .005). The 3-year locoregional control rate was 67%, 72%, 60%, and 59% for Groups A, B, C, and D, respectively (p = .48). The corresponding 3-year metastasis-free survival rates were 67%, 74%, 63%, and 79% (p = .31), and the corresponding 3-year survival rates were 60%, 63%, 50%, and 71% (p = .056). On multivariate analysis, Karnofsky performance status, histologic grade, T/N category, preradiotherapy hemoglobin level, completion of chemotherapy, and radiotherapy breaks were associated with the outcome. Conclusion: The four compared radiochemotherapy regimens were not significantly different regarding treatment outcomes. Two courses of cisplatin 20 mg/m{sup 2} on Days 1-5 were better tolerated than the other three regimens.

  3. FDG-PET Assessment of the Effect of Head and Neck Radiotherapy on Parotid Gland Glucose Metabolism

    SciTech Connect (OSTI)

    Roach, Michael C. [School of Medicine, Duke University Medical Center, Duke University, Durham, NC (United States); Turkington, Timothy G. [Department of Radiology, Duke University Medical Center, Duke University, Durham, NC (United States); Department of Biomedical Engineering, Duke University Medical Center, Duke University, Durham, NC (United States); Higgins, Kristin A. [Department of Radiation Oncology, Duke University Medical Center, Duke University, Durham, NC (United States); Hawk, Thomas C. [Department of Radiology, Duke University Medical Center, Duke University, Durham, NC (United States); Hoang, Jenny K. [Department of Radiology, Duke University Medical Center, Duke University, Durham, NC (United States); Department of Radiation Oncology, Duke University Medical Center, Duke University, Durham, NC (United States); Brizel, David M., E-mail: david.brizel@duke.edu [Department of Radiation Oncology, Duke University Medical Center, Duke University, Durham, NC (United States); Department of Surgery, Duke University Medical Center, Duke University, Durham, NC (United States)

    2012-01-01T23:59:59.000Z

    Purpose: Functional imaging with [F-18]-fluorodeoxyglucose positron emission tomography (FDG-PET) provides the opportunity to define the physiology of the major salivary glands before and after radiation therapy. The goal of this retrospective study was to identify the radiation dose-response relationship of parotid gland glucose metabolism in patients with head and neck squamous cell carcinoma (HNSCC). Materials and Methods: Forty-nine adults with HNSCC were identified who had curative intent intensity-modulated radiation therapy (IMRT) and FDG-PET imaging before and after treatment. Using a graphical user interface, contours were delineated for the parotid glands on axial CT slices while all authors were blinded to paired PET slices. Average and maximal standard uptake values (SUV) were measured within these anatomic regions. Changes in SUV and volume after radiation therapy were correlated with parotid gland dose-volume histograms from IMRT plans. Results: The average parotid gland volume was 30.7 mL and contracted 3.9 {+-} 1.9% with every increase of 10 Gy in mean dose (p = 0.04). However, within the first 3 months after treatment, there was a uniform reduction of 16.5% {+-} 7.3% regardless of dose. The average SUV{sub mean} of the glands was 1.63 {+-} 0.48 pretreatment and declined by 5.2% {+-} 2.5% for every increase of 10 Gy in mean dose (p = 0.04). The average SUV{sub max} was 4.07 {+-} 2.85 pretreatment and decreased in a sigmoid manner with mean dose. A threshold of 32 Gy for mean dose existed, after which SUV{sub max} declined rapidly. Conclusion: Radiation dose responses of the parotid glands can be measured by integrated CT/FDG-PET scans. Retrospective analysis showed sigmoidal declines in the maximum metabolism but linear declines in the average metabolism of the glands with dose. Future studies should correlate this decline in FDG uptake with saliva production to improve treatment planning.

  4. CT head-scan dosimetry in an anthropomorphic phantom and associated measurement of ACR accreditation-phantom imaging metrics under clinically representative scan conditions

    SciTech Connect (OSTI)

    Brunner, Claudia C.; Stern, Stanley H.; Chakrabarti, Kish [U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993 (United States)] [U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993 (United States); Minniti, Ronaldo [National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899 (United States)] [National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899 (United States); Parry, Marie I. [Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, Maryland 20889 (United States)] [Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, Maryland 20889 (United States); Skopec, Marlene [National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 (United States)] [National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 (United States)

    2013-08-15T23:59:59.000Z

    Purpose: To measure radiation absorbed dose and its distribution in an anthropomorphic head phantom under clinically representative scan conditions in three widely used computed tomography (CT) scanners, and to relate those dose values to metrics such as high-contrast resolution, noise, and contrast-to-noise ratio (CNR) in the American College of Radiology CT accreditation phantom.Methods: By inserting optically stimulated luminescence dosimeters (OSLDs) in the head of an anthropomorphic phantom specially developed for CT dosimetry (University of Florida, Gainesville), we measured dose with three commonly used scanners (GE Discovery CT750 HD, Siemens Definition, Philips Brilliance 64) at two different clinical sites (Walter Reed National Military Medical Center, National Institutes of Health). The scanners were set to operate with the same data-acquisition and image-reconstruction protocols as used clinically for typical head scans, respective of the practices of each facility for each scanner. We also analyzed images of the ACR CT accreditation phantom with the corresponding protocols. While the Siemens Definition and the Philips Brilliance protocols utilized only conventional, filtered back-projection (FBP) image-reconstruction methods, the GE Discovery also employed its particular version of an adaptive statistical iterative reconstruction (ASIR) algorithm that can be blended in desired proportions with the FBP algorithm. We did an objective image-metrics analysis evaluating the modulation transfer function (MTF), noise power spectrum (NPS), and CNR for images reconstructed with FBP. For images reconstructed with ASIR, we only analyzed the CNR, since MTF and NPS results are expected to depend on the object for iterative reconstruction algorithms.Results: The OSLD measurements showed that the Siemens Definition and the Philips Brilliance scanners (located at two different clinical facilities) yield average absorbed doses in tissue of 42.6 and 43.1 mGy, respectively. The GE Discovery delivers about the same amount of dose (43.7 mGy) when run under similar operating and image-reconstruction conditions, i.e., without tube current modulation and ASIR. The image-metrics analysis likewise showed that the MTF, NPS, and CNR associated with the reconstructed images are mutually comparable when the three scanners are run with similar settings, and differences can be attributed to different edge-enhancement properties of the applied reconstruction filters. Moreover, when the GE scanner was operated with the facility's scanner settings for routine head exams, which apply 50% ASIR and use only approximately half of the 100%-FBP dose, the CNR of the images showed no significant change. Even though the CNR alone is not sufficient to characterize the image quality and justify any dose reduction claims, it can be useful as a constancy test metric.Conclusions: This work presents a straightforward method to connect direct measurements of CT dose with objective image metrics such as high-contrast resolution, noise, and CNR. It demonstrates that OSLD measurements in an anthropomorphic head phantom allow a realistic and locally precise estimation of magnitude and spatial distribution of dose in tissue delivered during a typical CT head scan. Additional objective analysis of the images of the ACR accreditation phantom can be used to relate the measured doses to high contrast resolution, noise, and CNR.

  5. Improved Survival in Patients With Stage III-IV Head and Neck Cancer Treated With Radiotherapy as Primary Local Treatment Modality

    SciTech Connect (OSTI)

    Rusthoven, Kyle E.; Raben, David [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States); Chen Changhu [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States)], E-mail: Changhu.Chen@UCHSC.edu

    2008-10-01T23:59:59.000Z

    Purpose: To evaluate the overall and cause-specific survival in patients with Stage III-IVb head and neck squamous cell carcinoma treated with radiotherapy (RT) as the primary local treatment modality. Methods and Materials: The survival of patients with American Joint Committee on Cancer Stage III-IVb head and neck squamous cell carcinoma treated with primary RT was queried using the Surveillance, Epidemiology and End Results database. The effect of the year of treatment on overall and cause-specific survival was analyzed as a categorical and continuous variable. The patterns of care for these patients were also evaluated. Results: Between 1988 and 2004, 6,759 patients were identified. Survival was significantly improved in patients treated more recently. When analyzed as a continuous variable, each year was associated with a 3% and 4.1% reduction in the relative risk of overall and cause-specific mortality, respectively (p < 0.0001). Patients treated after 1998 had a 7.6% and 6.1% absolute improvement in overall and cause-specific survival, respectively, compared with patients treated before 1998 (overall survival, hazard ratio, 0.81; cause-specific survival, hazard ratio, 0.77; p < 0.0001). This benefit in survival was limited to tumors of the oral cavity, oropharynx, and hypopharynx. The use of RT increased among patients treated more recently. This shift in patterns of care was most pronounced for tumors of the larynx and hypopharynx. Conclusions: The overall and cause-specific survival of patients with Stage III-IVb head and neck squamous cell carcinoma treated with primary RT has improved with time. The improvement is consistent with that observed in a large meta-analysis of randomized patients treated with concurrent chemoradiotherapy.

  6. Use of External Beam Radiotherapy Is Associated With Reduced Incidence of Second Primary Head and Neck Cancer: A SEER Database Analysis

    SciTech Connect (OSTI)

    Rusthoven, Kyle [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States); Chen Changhu [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States)], E-mail: Changhu.Chen@uchsc.edu; Raben, David; Kavanagh, Brian [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States)

    2008-05-01T23:59:59.000Z

    Purpose: Patients with head and neck cancer have a significant risk of developing a second primary cancer of the head and neck. We hypothesized that treatment with external beam radiotherapy (RT) might reduce this risk, because RT can eradicate occult foci of second head and neck cancer (HNCA). Methods and Materials: The data of patients with Surveillance, Epidemiology, and End Results Historic Stage A localized squamous cell carcinoma of the oral cavity, larynx, and pharynx were queried using the Surveillance, Epidemiology, and End Results database. For patients treated with or without RT, the incidence of second HNCA was determined and compared using the log-rank method. Cox proportional hazards analysis was performed for each site, evaluating the influence of covariates on the risk of second HNCA. Results: Between 1973 and 1997, 27,985 patients were entered with localized HNCA. Of these patients, 44% had received RT and 56% had not. The 15-year incidence of second HNCA was 7.7% with RT vs. 10.5% without RT (hazard ratio 0.71, p <0.0001). The effect of RT was more profound in patients diagnosed between 1988 and 1997 (hazard ratio 0.53, p <0.0001) and those with pharynx primaries (hazard ratio 0.47, p <0.0001). On multivariate analysis, RT was associated with a reduced risk of second HNCA for pharynx (p <0.0001) and larynx (p = 0.04) tumors. For oral cavity primaries, RT was associated with an increased risk of second HNCA in patients treated before 1988 (p <0.001), but had no influence on patients treated between 1988 and 1997 (p = 0.91). Conclusion: For localized HNCA, RT is associated with a reduced incidence of second HNCA. These observations are consistent with the eradication of microscopic foci of second HNCA with external beam RT.

  7. Locally Advanced Stage IV Squamous Cell Carcinoma of the Head and Neck: Impact of Pre-Radiotherapy Hemoglobin Level and Interruptions During Radiotherapy

    SciTech Connect (OSTI)

    Rades, Dirk [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck (Germany); Department of Radiation Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (Germany)], E-mail: Rades.Dirk@gmx.net; Stoehr, Monika [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck (Germany); Kazic, Nadja [Department of Radiation Oncology, University Hospital Sarajevo, Sarajevo(Bosnia and Herzegowina); Hakim, Samer G. [Department of Oral and Maxillofacial Surgery, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck (Germany); Walz, Annette [Department of Head and Neck Surgery, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck (Germany); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic Scottsdale, AZ (United States); Dunst, Juergen [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck (Germany)

    2008-03-15T23:59:59.000Z

    Purpose: Stage IV head and neck cancer patients carry a poor prognosis. Clear understanding of prognostic factors can help to optimize care for the individual patient. This study investigated 11 potential prognostic factors including pre-radiotherapy hemoglobin level and interruptions during radiotherapy for overall survival (OS), metastases-free survival (MFS), and locoregional control (LC) after radiochemotherapy. Methods and Materials: Eleven factors were investigated in 153 patients receiving radiochemotherapy for Stage IV squamous cell head and neck cancer: age, gender, Karnofsky performance score (KPS), tumor site, grading, T stage, N stage, pre-radiotherapy hemoglobin level, surgery, chemotherapy type, and interruptions during radiotherapy >1 week. Results: On multivariate analysis, improved OS was associated with KPS 90-100 (relative risk [RR], 2.36; 95% confidence interval [CI], 1.20-4.93; p = .012), hemoglobin {>=}12 g/dL (RR, 1.88; 95% CI, 1.01-3.53; p = .048), and no radiotherapy interruptions (RR, 2.59; 95% CI, 1.15-5.78; p = .021). Improved LC was significantly associated with lower T stage (RR, 2.17; 95% CI, 1.16-4.63; p = .013), hemoglobin {>=}12 g/dL (RR, 4.12; 95% CI, 1.92-9.09; p < .001), surgery (RR, 2.67; 95% CI, 1.28-5.88; p = .008), and no radiotherapy interruptions (RR, 3.32; 95% CI, 1.26-8.79; p = .015). Improved MFS was associated with KPS 90-100 (RR, 3.41; 95% CI, 1.46-8.85; p = .012). Conclusions: Significant predictors for outcome in Stage IV head and neck cancer were performance status, stage, surgery, pre-radiotherapy hemoglobin level, and interruptions during radiotherapy >1 week. It appears important to avoid anemia and radiotherapy interruptions to achieve the best treatment results.

  8. Intensity-Modulated Radiotherapy is Associated With Improved Global Quality of Life Among Long-term Survivors of Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Chen, Allen M., E-mail: allen.chen@ucdmc.ucdavis.edu [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Farwell, D. Gregory; Luu, Quang [Department of Otolaryngology-Head and Neck Surgery, University of California Davis Cancer Center, Sacramento, CA (United States)] [Department of Otolaryngology-Head and Neck Surgery, University of California Davis Cancer Center, Sacramento, CA (United States); Vazquez, Esther G. [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)] [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Lau, Derick H. [Department of Medical Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)] [Department of Medical Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Purdy, James A. [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)] [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)

    2012-09-01T23:59:59.000Z

    Purpose: To compare the long-term quality of life among patients treated with and without intensity-modulated radiotherapy (IMRT) for head-and-neck cancer. Methods and Materials: University of Washington Quality of Life instrument scores were reviewed for 155 patients previously treated with radiation therapy for locally advanced head-and-neck cancer. All patients were disease free and had at least 2 years of follow-up. Eighty-four patients (54%) were treated with IMRT. The remaining 71 patients (46%) were treated with three-dimensional conformal radiotherapy (3D CRT) by use of initial opposed lateral fields matched to a low anterior neck field. Results: The mean global quality of life scores were 67.5 and 80.1 for the IMRT patients at 1 and 2 years, respectively, compared with 55.4 and 57.0 for the 3D CRT patients, respectively (p < 0.001). At 1 year after the completion of radiation therapy, the proportion of patients who rated their global quality of life as 'very good' or 'outstanding' was 51% and 41% among patients treated by IMRT and 3DCRT, respectively (p = 0.11). At 2 years, the corresponding percentages increased to 73% and 49%, respectively (p < 0.001). On multivariate analysis accounting for sex, age, radiation intent (definitive vs. postoperative), radiation dose, T stage, primary site, use of concurrent chemotherapy, and neck dissection, the use of IMRT was the only variable independently associated with improved quality of life (p = 0.01). Conclusion: The early quality of life improvements associated with IMRT not only are maintained but apparently become more magnified over time. These data provide powerful evidence attesting to the long-term benefits of IMRT for head-and-neck cancer.

  9. Accuracy of Computed Tomography for Predicting Pathologic Nodal Extracapsular Extension in Patients With Head-and-Neck Cancer Undergoing Initial Surgical Resection

    SciTech Connect (OSTI)

    Prabhu, Roshan S., E-mail: roshansprabhu@gmail.com [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Magliocca, Kelly R. [Department of Pathology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Hanasoge, Sheela [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Aiken, Ashley H.; Hudgins, Patricia A. [Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Hall, William A. [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Chen, Susie A. [Department of Radiation Oncology, University of Texas Southwestern, Dallas, Texas (United States); Eaton, Bree R.; Higgins, Kristin A. [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Saba, Nabil F. [Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Beitler, Jonathan J. [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States)

    2014-01-01T23:59:59.000Z

    Purpose: Nodal extracapsular extension (ECE) in patients with head-and-neck cancer increases the loco-regional failure risk and is an indication for adjuvant chemoradiation therapy (CRT). To reduce the risk of requiring trimodality therapy, patients with head-and-neck cancer who are surgical candidates are often treated with definitive CRT when preoperative computed tomographic imaging suggests radiographic ECE. The purpose of this study was to assess the accuracy of preoperative CT imaging for predicting pathologic nodal ECE (pECE). Methods and Materials: The study population consisted of 432 consecutive patients with oral cavity or locally advanced/nonfunctional laryngeal cancer who underwent preoperative CT imaging before initial surgical resection and neck dissection. Specimens with pECE had the extent of ECE graded on a scale from 1 to 4. Results: Radiographic ECE was documented in 46 patients (10.6%), and pECE was observed in 87 (20.1%). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 43.7%, 97.7%, 82.6%, and 87.3%, respectively. The sensitivity of radiographic ECE increased from 18.8% for grade 1 to 2 ECE, to 52.9% for grade 3, and 72.2% for grade 4. Radiographic ECE criteria of adjacent structure invasion was a better predictor than irregular borders/fat stranding for pECE. Conclusions: Radiographic ECE has poor sensitivity, but excellent specificity for pECE in patients who undergo initial surgical resection. PPV and NPV are reasonable for clinical decision making. The performance of preoperative CT imaging increased as pECE grade increased. Patients with resectable head-and-neck cancer with radiographic ECE based on adjacent structure invasion are at high risk for high-grade pECE requiring adjuvant CRT when treated with initial surgery; definitive CRT as an alternative should be considered where appropriate.

  10. Automatic segmentation of head and neck CT images for radiotherapy treatment planning using multiple atlases, statistical appearance models, and geodesic active contours

    SciTech Connect (OSTI)

    Fritscher, Karl D., E-mail: Karl.Fritscher@umit.at; Sharp, Gregory [Department for Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114 (United States)] [Department for Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114 (United States); Peroni, Marta [Paul Scherrer Institut, Villigen 5232 (Switzerland)] [Paul Scherrer Institut, Villigen 5232 (Switzerland); Zaffino, Paolo; Spadea, Maria Francesca [Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro 88100 (Italy)] [Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro 88100 (Italy); Schubert, Rainer [Institute for Biomedical Image Analysis, Private University of Health Sciences, Medical Informatics and Technology, Hall in Tirol 6060 (Austria)] [Institute for Biomedical Image Analysis, Private University of Health Sciences, Medical Informatics and Technology, Hall in Tirol 6060 (Austria)

    2014-05-15T23:59:59.000Z

    Purpose: Accurate delineation of organs at risk (OARs) is a precondition for intensity modulated radiation therapy. However, manual delineation of OARs is time consuming and prone to high interobserver variability. Because of image artifacts and low image contrast between different structures, however, the number of available approaches for autosegmentation of structures in the head-neck area is still rather low. In this project, a new approach for automated segmentation of head-neck CT images that combine the robustness of multiatlas-based segmentation with the flexibility of geodesic active contours and the prior knowledge provided by statistical appearance models is presented. Methods: The presented approach is using an atlas-based segmentation approach in combination with label fusion in order to initialize a segmentation pipeline that is based on using statistical appearance models and geodesic active contours. An anatomically correct approximation of the segmentation result provided by atlas-based segmentation acts as a starting point for an iterative refinement of this approximation. The final segmentation result is based on using model to image registration and geodesic active contours, which are mutually influencing each other. Results: 18 CT images in combination with manually segmented labels of parotid glands and brainstem were used in a leave-one-out cross validation scheme in order to evaluate the presented approach. For this purpose, 50 different statistical appearance models have been created and used for segmentation. Dice coefficient (DC), mean absolute distance and max. Hausdorff distance between the autosegmentation results and expert segmentations were calculated. An average Dice coefficient of DC = 0.81 (right parotid gland), DC = 0.84 (left parotid gland), and DC = 0.86 (brainstem) could be achieved. Conclusions: The presented framework provides accurate segmentation results for three important structures in the head neck area. Compared to a segmentation approach based on using multiple atlases in combination with label fusion, the proposed hybrid approach provided more accurate results within a clinically acceptable amount of time.

  11. Head-On and Long Range Beam-Beam Interactions in the LHC: Effective Tune Spread and Beam Stability Due to Landau Damping

    E-Print Network [OSTI]

    Buffat, X; Mtral, E; Mounet, N; Pieloni, T

    2013-01-01T23:59:59.000Z

    We discuss the Landau damping of coherent instabilities in the presence of betatron tune spread. This tune spread can originate from dedicated non-linear magnets such as octupoles, or through the beam-beam interaction. In the latter case we have to distinguish the contribution from head- on and parasitic beam-beam interactions and the collision pattern of different bunches plays an important role. The interplay of these sources of tune spread and the resulting stability is discussed for the case of the LHC.

  12. Dosimetric influences of rotational setup errors on head and neck carcinoma intensity-modulated radiation therapy treatments

    SciTech Connect (OSTI)

    Fu, Weihua, E-mail: fuw@upmc.edu [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States); Yang, Yong [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States); Yue, Ning J. [Department of Radiation Oncology, UMDNJ-Robert Wood Johnson Medical School, The Cancer Institute of New Jersey, New Brunswick, NJ (United States); Heron, Dwight E.; Saiful Huq, M. [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States)

    2013-07-01T23:59:59.000Z

    The purpose of this work is to investigate the dosimetric influence of the residual rotational setup errors on head and neck carcinoma (HNC) intensity-modulated radiation therapy (IMRT) with routine 3 translational setup corrections and the adequacy of this routine correction. A total of 66 kV cone beam computed tomography (CBCT) image sets were acquired on the first day of treatment and weekly thereafter for 10 patients with HNC and were registered with the corresponding planning CT images, using 2 3-dimensional (3D) rigid registration methods. Method 1 determines the translational setup errors only, and method 2 determines 6-degree (6D) setup errors, i.e., both rotational and translational setup errors. The 6D setup errors determined by method 2 were simulated in the treatment planning system and were then corrected using the corresponding translational data determined by method 1. For each patient, dose distributions for 6 to 7 fractions with various setup uncertainties were generated, and a plan sum was created to determine the total dose distribution through an entire course and was compared with the original treatment plan. The average rotational setup errors were 0.7 1.0, 0.11.9, and 0.30.7 around left-right (LR), anterior-posterior (AP), and superior-inferior (SI) axes, respectively. With translational corrections determined by method 1 alone, the dose deviation could be large from fraction to fraction. For a certain fraction, the decrease in prescription dose coverage (V{sub p}) and the dose that covers 95% of target volume (D{sub 95}) could be up to 15.8% and 13.2% for planning target volume (PTV), and the decrease in V{sub p} and the dose that covers 98% of target volume (D{sub 98}) could be up to 9.8% and 5.5% for the clinical target volume (CTV). However, for the entire treatment course, for PTV, the plan sum showed that the average V{sub p} was decreased by 4.2% and D{sub 95} was decreased by 1.2 Gy for the first phase of IMRT with a prescription dose of 50 Gy. For CTV, the plan sum showed that the average V{sub p} was decreased by 0.8% and D{sub 98}, relative to prescription dose, was not decreased. Among these 10 patients, the plan sum showed that the dose to 1-cm{sup 3} spinal cord (D{sub 1cm{sup 3}}) increased no more than 1 Gy for 7 patients and more than 2 Gy for 2 patients. The average increase in D{sub 1cm{sup 3}} was 1.2 Gy. The study shows that, with translational setup error correction, the overall CTV V{sub p} has a minor decrease with a 5-mm margin from CTV to PTV. For the spinal cord, a noticeable dose increase was observed for some patients. So to decide whether the routine clinical translational setup error correction is adequate for this HNC IMRT technique, the dosimetric influence of rotational setup errors should be evaluated carefully from case to case when organs at risk are in close proximity to the target.

  13. Modeling the dosimetry of organ-at-risk in head and neck IMRT planning: An intertechnique and interinstitutional study

    SciTech Connect (OSTI)

    Lian, Jun, E-mail: jun-lian@med.unc.edu; Chera, Bhishamjit S.; Chang, Sha [Department of Radiation Oncology, The University of North Carolina, Chapel Hill, North Carolina 27599 (United States)] [Department of Radiation Oncology, The University of North Carolina, Chapel Hill, North Carolina 27599 (United States); Yuan, Lulin, E-mail: lulin.yuan@duke.edu; Yoo, David P.; Yin, FangFang; Wu, Q. Jackie, E-mail: jackie.wu@duke.edu [Department of Radiation Oncology, Duke University, Durham, North Carolina 27710 (United States); Ge, Yaorong [Department of Software and Information Systems, The University of North Carolina, Charlotte, North Carolina 28223 (United States)] [Department of Software and Information Systems, The University of North Carolina, Charlotte, North Carolina 28223 (United States)

    2013-12-15T23:59:59.000Z

    Purpose: To build a statistical model to quantitatively correlate the anatomic features of structures and the corresponding dose-volume histogram (DVH) of head and neck (HN) Tomotherapy (Tomo) plans. To study if the model built upon one intensity modulated radiation therapy (IMRT) technique (such as conventional Linac) can be used to predict anticipated organs-at-risk (OAR) DVH of patients treated with a different IMRT technique (such as Tomo). To study if the model built upon the clinical experience of one institution can be used to aid IMRT planning for another institution. Methods: Forty-four Tomotherapy intensity modulate radiotherapy plans of HN cases (Tomo-IMRT) from Institution A were included in the study. A different patient group of 53 HN fixed gantry IMRT (FG-IMRT) plans was selected from Institution B. The analyzed OARs included the parotid, larynx, spinal cord, brainstem, and submandibular gland. Two major groups of anatomical features were considered: the volumetric information and the spatial information. The volume information includes the volume of target, OAR, and overlapped volume between target and OAR. The spatial information of OARs relative to PTVs was represented by the distance-to-target histogram (DTH). Important anatomical and dosimetric features were extracted from DTH and DVH by principal component analysis. Two regression models, one for Tomotherapy plan and one for IMRT plan, were built independently. The accuracy of intratreatment-modality model prediction was validated by a leave one out cross-validation method. The intertechnique and interinstitution validations were performed by using the FG-IMRT model to predict the OAR dosimetry of Tomo-IMRT plans. The dosimetry of OARs, under the same and different institutional preferences, was analyzed to examine the correlation between the model prediction and planning protocol. Results: Significant patient anatomical factors contributing to OAR dose sparing in HN Tomotherapy plans have been analyzed and identified. For all the OARs, the discrepancies of dose indices between the model predicted values and the actual plan values were within 2.1%. Similar results were obtained from the modeling of FG-IMRT plans. The parotid gland was spared in a comparable fashion during the treatment planning of two institutions. The model based on FG-IMRT plans was found to predict the median dose of the parotid of Tomotherapy plans quite well, with a mean error of 2.6%. Predictions from the FG-IMRT model suggested the median dose of the larynx, median dose of the brainstem and D2 of the brainstem could be reduced by 10.5%, 12.8%, and 20.4%, respectively, in the Tomo-IMRT plans. This was found to be correlated to the institutional differences in OAR constraint settings. Re-planning of six Tomotherapy patients confirmed the potential of optimization improvement predicted by the FG-IMRT model was correct. Conclusions: The authors established a mathematical model to correlate the anatomical features and dosimetric indexes of OARs of HN patients in Tomotherapy plans. The model can be used for the setup of patient-specific OAR dose sparing goals and quality control of planning results. The institutional clinical experience was incorporated into the model which allows the model from one institution to generate a reference plan for another institution, or another IMRT technique.

  14. An Integrated Experimental and Computational Investigation into the Dynamic Loads and Free-surface Wave-Field Perturbations Induced by Head-Sea Regular Waves on a 1/8.25 Scale-Model of the R/V ATHENA

    E-Print Network [OSTI]

    Ratcliffe, Toby; O'Shea, Thomas T; Fu, Thomas; Russell, Lauren; Dommermuth, Douglas G

    2014-01-01T23:59:59.000Z

    A 1/8.25 scale-model of the U.S. Navy Research Vessel ATHENA was tested in regular head-sea waves to obtain data for validation of computational fluid dynamics (CFD) predictive tools. The experiments were performed in the David Taylor Model Basin at the Naval Surface Warfare Center (NSWC). With the model towed fixed in head-seas, horizontal and vertical loads on the model were obtained at two Froude numbers, $F_r=0.25$ and $F_r=0.43$. The model was run at two conditions of head-sea wavelengths corresponding to $\\lambda=2L_o$ and $\\lambda=1/2L_o$ with $H/\\lambda=0.03$, where $L_o$ is the length of the model and $H=2 a$ is the wave height. The wave field perturbations induced by the head-sea waves were quantified from free-surface images generated by a laser light sheet. Predictions of the horizontal and vertical loads on the model in regular head sea waves were made with the Numerical Flow Analysis (NFA) code. Numerical predictions of the wave-field perturbations were compared with the experimental data and th...

  15. Catchline International Journal of Geographical Information System, Vol. X, No. X, Month 2006, xxxxxx Running heads (verso) J. Zhou and R. Golledge (recto) A three-step map matching method in the GIS environment A Three-step General Map Matching Method in the GIS Environment: Travel/Transportation Study Perspective

    E-Print Network [OSTI]

    Zhou, Jianyu Jack; Golledge, R G

    2006-01-01T23:59:59.000Z

    Information System, Vol. X, No. X, Month 2006, xxxxxx Running heads (verso) (recto) J. Zhou and R. Golledge A

  16. The effect of head size/shape, miscentering, and bowtie filter on peak patient tissue doses from modern brain perfusion 256-slice CT: How can we minimize the risk for deterministic effects?

    SciTech Connect (OSTI)

    Perisinakis, Kostas; Seimenis, Ioannis; Tzedakis, Antonis; Papadakis, Antonios E.; Damilakis, John [Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Heraklion 71003, Crete (Greece); Medical Diagnostic Center 'Ayios Therissos,' P.O. Box 28405, Nicosia 2033, Cyprus and Department of Medical Physics, Medical School, Democritus University of Thrace, Panepistimioupolis, Dragana 68100, Alexandroupolis (Greece); Department of Medical Physics, University Hospital of Heraklion, P.O. Box 1352, Heraklion 71110, Crete (Greece); Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Heraklion 71003, Crete (Greece)

    2013-01-15T23:59:59.000Z

    Purpose: To determine patient-specific absorbed peak doses to skin, eye lens, brain parenchyma, and cranial red bone marrow (RBM) of adult individuals subjected to low-dose brain perfusion CT studies on a 256-slice CT scanner, and investigate the effect of patient head size/shape, head position during the examination and bowtie filter used on peak tissue doses. Methods: The peak doses to eye lens, skin, brain, and RBM were measured in 106 individual-specific adult head phantoms subjected to the standard low-dose brain perfusion CT on a 256-slice CT scanner using a novel Monte Carlo simulation software dedicated for patient CT dosimetry. Peak tissue doses were compared to corresponding thresholds for induction of cataract, erythema, cerebrovascular disease, and depression of hematopoiesis, respectively. The effects of patient head size/shape, head position during acquisition and bowtie filter used on resulting peak patient tissue doses were investigated. The effect of eye-lens position in the scanned head region was also investigated. The effect of miscentering and use of narrow bowtie filter on image quality was assessed. Results: The mean peak doses to eye lens, skin, brain, and RBM were found to be 124, 120, 95, and 163 mGy, respectively. The effect of patient head size and shape on peak tissue doses was found to be minimal since maximum differences were less than 7%. Patient head miscentering and bowtie filter selection were found to have a considerable effect on peak tissue doses. The peak eye-lens dose saving achieved by elevating head by 4 cm with respect to isocenter and using a narrow wedge filter was found to approach 50%. When the eye lies outside of the primarily irradiated head region, the dose to eye lens was found to drop to less than 20% of the corresponding dose measured when the eye lens was located in the middle of the x-ray beam. Positioning head phantom off-isocenter by 4 cm and employing a narrow wedge filter results in a moderate reduction of signal-to-noise ratio mainly to the peripheral region of the phantom. Conclusions: Despite typical peak doses to skin, eye lens, brain, and RBM from the standard low-dose brain perfusion 256-slice CT protocol are well below the corresponding thresholds for the induction of erythema, cataract, cerebrovascular disease, and depression of hematopoiesis, respectively, every effort should be made toward optimization of the procedure and minimization of dose received by these tissues. The current study provides evidence that the use of the narrower bowtie filter available may considerably reduce peak absorbed dose to all above radiosensitive tissues with minimal deterioration in image quality. Considerable reduction in peak eye-lens dose may also be achieved by positioning patient head center a few centimeters above isocenter during the exposure.

  17. {sup 18}F-FLT uptake kinetics in head and neck squamous cell carcinoma: A PET imaging study

    SciTech Connect (OSTI)

    Liu, Dan, E-mail: dan.liu@oncology.ox.ac.uk; Fenwick, John D. [Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ (United Kingdom)] [Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ (United Kingdom); Chalkidou, Anastasia; Landau, David B.; Marsden, Paul K. [Division of Imaging Sciences and Biomedical Engineering, School of Medicine, King's College London, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH (United Kingdom)] [Division of Imaging Sciences and Biomedical Engineering, School of Medicine, King's College London, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH (United Kingdom)

    2014-04-15T23:59:59.000Z

    Purpose: To analyze the kinetics of 3{sup ?}-deoxy-3{sup ?}-[F-18]-fluorothymidine (18F-FLT) uptake by head and neck squamous cell carcinomas and involved nodes imaged using positron emission tomography (PET). Methods: Two- and three-tissue compartment models were fitted to 12 tumor time-activity-curves (TACs) obtained for 6 structures (tumors or involved nodes) imaged in ten dynamic PET studies of 1 h duration, carried out for five patients. The ability of the models to describe the data was assessed using a runs test, the Akaike information criterion (AIC) and leave-one-out cross-validation. To generate parametric maps the models were also fitted to TACs of individual voxels. Correlations between maps of different parameters were characterized using Pearson'sr coefficient; in particular the phosphorylation rate-constants k{sub 3-2tiss} and k{sub 5} of the two- and three-tissue models were studied alongside the flux parameters K{sub FLT-2tiss} and K{sub FLT} of these models, and standardized uptake values (SUV). A methodology based on expectation-maximization clustering and the Bayesian information criterion (EM-BIC clustering) was used to distil the information from noisy parametric images. Results: Fits of two-tissue models 2C3K and 2C4K and three-tissue models 3C5K and 3C6K comprising three, four, five, and six rate-constants, respectively, pass the runs test for 4, 8, 10, and 11 of 12 tumor TACs. The three-tissue models have lower AIC and cross-validation scores for nine of the 12 tumors. Overall the 3C6K model has the lowest AIC and cross-validation scores and its fitted parameter values are of the same orders of magnitude as literature estimates. Maps ofK{sub FLT} and K{sub FLT-2tiss} are strongly correlated (r = 0.85) and also correlate closely with SUV maps (r = 0.72 for K{sub FLT-2tiss}, 0.64 for K{sub FLT}). Phosphorylation rate-constant maps are moderately correlated with flux maps (r = 0.48 for k{sub 3-2tiss} vs K{sub FLT-2tiss} and r = 0.68 for k{sub 5} vs K{sub FLT}); however, neither phosphorylation rate-constant correlates significantly with SUV. EM-BIC clustering reduces the parametric maps to a small number of levelson average 5.8, 3.5, 3.4, and 1.4 for K{sub FLT-2tiss}, K{sub FLT}, k{sub 3-2tiss}, and k{sub 5.} This large simplification is potentially useful for radiotherapy dose-painting, but demonstrates the high noise in some maps. Statistical simulations show that voxel level noise degrades TACs generated from the 3C6K model sufficiently that the average AIC score, parameter bias, and total uncertainty of 2C4K model fits are similar to those of 3C6K fits, whereas at the whole tumor level the scores are lower for 3C6K fits. Conclusions: For the patients studied here, whole tumor FLT uptake time-courses are represented better overall by a three-tissue than by a two-tissue model. EM-BIC clustering simplifies noisy parametric maps, providing the best description of the underlying information they contain and is potentially useful for radiotherapy dose-painting. However, the clustering highlights the large degree of noise present in maps of the phosphorylation rate-constantsk{sub 5} and k{sub 3-2tiss}, which are conceptually tightly linked to cellular proliferation. Methods must be found to make these maps more robusteither by constraining other model parameters or modifying dynamic imaging protocols.

  18. Investigation of Head Burns in Adult Salmonids : Phase 1, Examination of Fish at Lookingglass Hatchery in 1996 : Addendum to Final Report.

    SciTech Connect (OSTI)

    Groberg, Warren J.

    1996-11-01T23:59:59.000Z

    This information is an addendum to the report 'Investigation of Head Burns in Adult Salmonids, Phase 1: Examination of Fish at Lower Granite Dam, July 2, 1996' by Ralph Elston because there may be relevant observations included here. The author of this document participated in the examinations at Lower Granite Dam described in that report. Because of Endangered Species Act issues, the Rapid River stock of spring chinook salmon reared at Lookingglass Hatchery on the Grande Ronde River in northeastern Oregon are annually being captured as returning adults at Lower Granite Dam on the Snake River and trucked to Lookingglass. During the peak migration period they are held in an adult holding facility at Lower Granite for as long as 72 hours and then transported by truck to Lookingglass for holding in an adult pond for spawning. In 1996 a total of 572 adults were transported from Lower Granite Dam between May 3 and August 6. Two-hundred eighty-one of these were later transported from Lookingglass to Wallowa Hatchery for artificial spawning and the remaining 291 were held for spawning at Lookingglass. On May 21, 24, 30 and June 2, 1996 hatchery personnel identified a total of 32 off-loaded fish with lesions on the dorsal area of the head they described as having the appearance of blisters (Robert Lund personal communication). By date these are shown in Table 1 (fish with similar lesions were also observed on May 27 but the number of these was not recorded). Such lesions were not observed on fish offloaded on any other dates. On May 24, 1996 hatchery personnel took photographs of fish with these lesions but do to light-meter problems the photographs did not turn out. On June 28, 1996 personnel of the Oregon Department of Fish and Wildlife (ODFW) Fish Pathology laboratory in La Grande were notified by James Lauman, ODFW Northeast Region supervisor, of discussions and concerns of head burn on returning adult chinook while he was on a visitation to Lower Granite Dam. That led to subsequent investigations at Lower Granite Dam (Ralph Elston 1996) and Lookingglass Hatchery. The results of the Lookingglass investigations are reported here.

  19. Ultrasonic Nakagami-parameter characterization of parotid-gland injury following head-and-neck radiotherapy: A feasibility study of late toxicity

    SciTech Connect (OSTI)

    Yang, Xiaofeng; Wu, Ning; Wang, Yuefeng [Radiation Oncology, Emory University, Atlanta, Georgia 30322 (United States)] [Radiation Oncology, Emory University, Atlanta, Georgia 30322 (United States); Tridandapani, Srini [Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322 (United States) [Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322 (United States); School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia 30322 (United States); Beitler, Jonathan J.; Yu, David S.; Curran, Walter J.; Liu, Tian, E-mail: tliu34@emory.edu [Radiation Oncology, Emory University, Atlanta, Georgia 30322 and Winship Cancer Institute, Emory University, Atlanta, Georgia 30322 (United States)] [Radiation Oncology, Emory University, Atlanta, Georgia 30322 and Winship Cancer Institute, Emory University, Atlanta, Georgia 30322 (United States); Bruner, Deborah W. [Radiation Oncology, Emory University, Atlanta, Georgia 30322 (United States) [Radiation Oncology, Emory University, Atlanta, Georgia 30322 (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia 30322 (United States); School of Nursing, Emory University, Atlanta, Georgia 30322 (United States)

    2014-02-15T23:59:59.000Z

    Purpose: The study aims to investigate whether Nakagami parametersestimated from the statistical distribution of the backscattered ultrasound radio-frequency (RF) signalscould provide a means for quantitative characterization of parotid-gland injury resulting from head-and-neck radiotherapy. Methods: A preliminary clinical study was conducted with 12 postradiotherapy patients and 12 healthy volunteers. Each participant underwent one ultrasound study in which ultrasound scans were performed in the longitudinal, i.e., vertical orientation on the bilateral parotids. For the 12 patients, the mean radiation dose to the parotid glands was 37.7 9.5 Gy, and the mean follow-up time was 16.3 4.8 months. All enrolled patients experienced grade 1 or 2 late salivary-gland toxicity (RTOG/EORTC morbidity scale). The normal parotid glands served as the control group. The Nakagami-scaling and Nakagami-shape parameters were computed from the RF data to quantify radiation-induced parotid-gland changes. Results: Significant differences in Nakagami parameters were observed between the normal and postradiotherapy parotid glands. Compared with the control group, the Nakagami-scaling parameter of the postradiotherapy group decreased by 25.8% (p < 0.001), and the Nakagami-shape parameter decreased by 31.3% (p < 0.001). The area under the receiver operating characteristic curve was 0.85 for the Nakagami-scaling parameter and was 0.95 for the Nakagami-shape parameter, which further demonstrated the diagnostic efficiency of the Nakagami parameters. Conclusions: Nakagami parameters could be used to quantitatively measure parotid-gland injury following head-and-neck radiotherapy. Moreover, the clinical feasibility was demonstrated and this study provides meaningful preliminary data for future clinical investigation.

  20. The Impact of Individual In Vivo Repair of DNA Double-Strand Breaks on Oral Mucositis in Adjuvant Radiotherapy of Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Fleckenstein, Jochen, E-mail: rajfle@uks.eu [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Kuehne, Martin; Seegmueller, Katharina; Derschang, Sarah; Melchior, Patrick [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Graeber, Stefan [Institute for Medical Biometry, Epidemiology und Medical Informatics (IMBEI), Saarland University Medical School, Homburg (Germany); Fricke, Andreas; Ruebe, Claudia E.; Ruebe, Christian [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany)

    2011-12-01T23:59:59.000Z

    Purpose: To evaluate the impact of individual in vivo DNA double-strand break (DSB) repair capacity on the incidence of severe oral mucositis in patients with head-and-neck cancer undergoing adjuvant radiotherapy (RT) or radiochemotherapy (RCT). Patients and Methods: Thirty-one patients with resected head-and-neck cancer undergoing adjuvant RT or RCT were examined. Patients underwent RT of the primary tumor site and locoregional lymph nodes with a total dose of 60-66 Gy (single dose 2 Gy, five fractions per week). Chemotherapy consisted of two cycles of cisplatin and 5-fluorouracil. To assess DSB repair, {gamma}-H2AX foci in blood lymphocytes were quantified before and 0.5 h, 2.5 h, 5 h, and 24 h after in vivo radiation exposure (the first fraction of RT). World Health Organization scores for oral mucositis were documented weekly and correlated with DSB repair. Results: Sixteen patients received RT alone; 15 patients received RCT. In patients who developed Grade {>=} 3 mucositis (n = 18) the amount of unrepaired DSBs 24 h after radiation exposure and DSB repair half-times did not differ significantly from patients with Grade {<=}2 mucositis (n = 13). Patients with a proportion of unrepaired DSBs after 24 h higher than the mean value + one standard deviation had an increased incidence of severe oral mucositis. Conclusions: Evaluation of in vivo DSB repair by determination of {gamma}-H2AX foci loss is feasible in clinical practice and allows identification of patients with impaired DSB repair. The incidence of oral mucositis is not closely correlated with DSB repair under the evaluated conditions.

  1. The College of Engineering of The Pennsylvania State University invites applications for the position of Head of the Department of Electrical Engineering. The successful candidate must have an established and widely recognized

    E-Print Network [OSTI]

    Guiltinan, Mark

    for the position of Head of the Department of Electrical Engineering. The successful candidate must have an established and widely recognized reputation in Electrical Engineering. An earned doctorate is required the research and educational initiatives of Electrical Engineering; (2) building upon existing departmental

  2. Assessment of Interfraction Patient Setup for Head-and-Neck Cancer Intensity Modulated Radiation Therapy Using Multiple Computed Tomography-Based Image Guidance

    SciTech Connect (OSTI)

    Qi, X. Sharon, E-mail: xqi@mednet.ucla.edu [Department of Radiation Oncology, David of Geffen School of Medicine at UCLA, Los Angeles, California (United States); Hu, Angie Y. [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado (United States)] [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado (United States); Lee, Steve P.; Lee, Percy; DeMarco, John [Department of Radiation Oncology, David of Geffen School of Medicine at UCLA, Los Angeles, California (United States)] [Department of Radiation Oncology, David of Geffen School of Medicine at UCLA, Los Angeles, California (United States); Li, X. Allen [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin (United States)] [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin (United States); Steinberg, Michael L.; Kupelian, Patrick; Low, Daniel [Department of Radiation Oncology, David of Geffen School of Medicine at UCLA, Los Angeles, California (United States)] [Department of Radiation Oncology, David of Geffen School of Medicine at UCLA, Los Angeles, California (United States)

    2013-07-01T23:59:59.000Z

    Purpose: Various image guidance systems are commonly used in conjunction with intensity modulated radiation therapy (IMRT) in head-and-neck cancer irradiation. The purpose of this study was to assess interfraction patient setup variations for 3 computed tomography (CT)-based on-board image guided radiation therapy (IGRT) modalities. Methods and Materials: A total of 3302 CT scans for 117 patients, including 53 patients receiving megavoltage cone-beam CT (MVCBCT), 29 receiving kilovoltage cone-beam CT (KVCBCT), and 35 receiving megavoltage fan-beam CT (MVFBCT), were retrospectively analyzed. The daily variations in the mediolateral (ML), craniocaudal (CC), and anteroposterior (AP) dimensions were measured. The clinical target volume-to-planned target volume (CTV-to-PTV) margins were calculated using 2.5? + 0.7 ?, where ? and ? were systematic and random positioning errors, respectively. Various patient characteristics for the MVCBCT group, including weight, weight loss, tumor location, and initial body mass index, were analyzed to determine their possible correlation with daily patient setup. Results: The average interfraction displacements ( standard deviation) in the ML, CC, and AP directions were 0.5 1.5, ?0.3 2.0, and 0.3 1.7 mm (KVCBCT); 0.2 1.9, ?0.2 2.4, and 0.0 1.7 mm (MVFBCT); and 0.0 1.8, 0.5 1.7, and 0.8 3.0 mm (MVCBCT). The day-to-day random errors for KVCBCT, MVFBCT, and MVCBCT were 1.4-1.6, 1.7, and 2.0-2.1 mm. The interobserver variations were 0.8, 1.1, and 0.7 mm (MVCBCT); 0.5, 0.4, and 0.8 mm (MVFBCT); and 0.5, 0.4, and 0.6 mm (KVCBCT) in the ML, CC, and AP directions, respectively. The maximal calculated uniform CTV-to-PTV margins were 5.6, 6.9, and 8.9 mm for KVCBCT, MVFBCT, and MVCBCT, respectively. For the evaluated patient characteristics, the calculated margins for different patient parameters appeared to differ; analysis of variance (ANOVA) and/or t test analysis found no statistically significant setup difference in any direction. Conclusions: Daily random setup errors and CTV-to-PTV margins for treatment of head-and-neck cancer were affected by imaging quality. Our data indicated that larger margins were associated with MVFBCT and MVCBCT, compared with smaller margins for KVCBCT. IGRT modalities with better image quality are encouraged in clinical practice.

  3. Measuring uncertainty in dose delivered to the cochlea due to setup error during external beam treatment of patients with cancer of the head and neck

    SciTech Connect (OSTI)

    Yan, M.; Lovelock, D.; Hunt, M.; Mechalakos, J.; Hu, Y.; Pham, H.; Jackson, A., E-mail: jacksona@mskcc.org [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10065 (United States)

    2013-12-15T23:59:59.000Z

    Purpose: To use Cone Beam CT scans obtained just prior to treatments of head and neck cancer patients to measure the setup error and cumulative dose uncertainty of the cochlea. Methods: Data from 10 head and neck patients with 10 planning CTs and 52 Cone Beam CTs taken at time of treatment were used in this study. Patients were treated with conventional fractionation using an IMRT dose painting technique, most with 33 fractions. Weekly radiographic imaging was used to correct the patient setup. The authors used rigid registration of the planning CT and Cone Beam CT scans to find the translational and rotational setup errors, and the spatial setup errors of the cochlea. The planning CT was rotated and translated such that the cochlea positions match those seen in the cone beam scans, cochlea doses were recalculated and fractional doses accumulated. Uncertainties in the positions and cumulative doses of the cochlea were calculated with and without setup adjustments from radiographic imaging. Results: The mean setup error of the cochlea was 0.04 0.33 or 0.06 0.43 cm for RL, 0.09 0.27 or 0.07 0.48 cm for AP, and 0.00 0.21 or ?0.24 0.45 cm for SI with and without radiographic imaging, respectively. Setup with radiographic imaging reduced the standard deviation of the setup error by roughly 12 mm. The uncertainty of the cochlea dose depends on the treatment plan and the relative positions of the cochlea and target volumes. Combining results for the left and right cochlea, the authors found the accumulated uncertainty of the cochlea dose per fraction was 4.82 (0.3916.8) cGy, or 10.1 (0.832.4) cGy, with and without radiographic imaging, respectively; the percentage uncertainties relative to the planned doses were 4.32% (0.28%9.06%) and 10.2% (0.7%63.6%), respectively. Conclusions: Patient setup error introduces uncertainty in the position of the cochlea during radiation treatment. With the assistance of radiographic imaging during setup, the standard deviation of setup error reduced by 31%, 42%, and 54% in RL, AP, and SI direction, respectively, and consequently, the uncertainty of the mean dose to cochlea reduced more than 50%. The authors estimate that the effects of these uncertainties on the probability of hearing loss for an individual patient could be as large as 10%.

  4. Alpha-2 Heremans Schmid Glycoprotein (AHSG) Modulates Signaling Pathways in Head and Neck Squamous Cell Carcinoma Cell Line SQ20B

    SciTech Connect (OSTI)

    Thompson, Pamela D.; Sakwe, Amos [Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208 (United States); Koumangoye, Rainelli [Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Yarbrough, Wendell G. [Division of Otolaryngology, Departments of Surgery and Pathology and Yale Cancer Center, Yale University, New Haven, CT 06520 (United States); Ochieng, Josiah [Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208 (United States); Marshall, Dana R., E-mail: dmarshall@mmc.edu [Department of Pathology, Anatomy and Cell Biology, Meharry Medical College, Nashville, TN 37208 (United States)

    2014-02-15T23:59:59.000Z

    This study was performed to identify the potential role of Alpha-2 Heremans Schmid Glycoprotein (AHSG) in Head and Neck Squamous Cell Carcinoma (HNSCC) tumorigenesis using an HNSCC cell line model. HNSCC cell lines are unique among cancer cell lines, in that they produce endogenous AHSG and do not rely, solely, on AHSG derived from serum. To produce our model, we performed a stable transfection to down-regulate AHSG in the HNSCC cell line SQ20B, resulting in three SQ20B sublines, AH50 with 50% AHSG production, AH20 with 20% AHSG production and EV which is the empty vector control expressing wild-type levels of AHSG. Utilizing these sublines, we examined the effect of AHSG depletion on cellular adhesion, proliferation, migration and invasion in a serum-free environment. We demonstrated that sublines EV and AH50 adhered to plastic and laminin significantly faster than the AH20 cell line, supporting the previously reported role of exogenous AHSG in cell adhesion. As for proliferative potential, EV had the greatest amount of proliferation with AH50 proliferation significantly diminished. AH20 cells did not proliferate at all. Depletion of AHSG also diminished cellular migration and invasion. TGF-? was examined to determine whether levels of the TGF-? binding AHSG influenced the effect of TGF-? on cell signaling and proliferation. Whereas higher levels of AHSG blunted TGF-? influenced SMAD and ERK signaling, it did not clearly affect proliferation, suggesting that AHSG influences on adhesion, proliferation, invasion and migration are primarily due to its role in adhesion and cell spreading. The previously reported role of AHSG in potentiating metastasis via protecting MMP-9 from autolysis was also supported in this cell line based model system of endogenous AHSG production in HNSCC. Together, these data show that endogenously produced AHSG in an HNSCC cell line, promotes in vitro cellular properties identified as having a role in tumorigenesis. Highlights: Head and neck squamous cell carcinoma cell lines synthesize and secret AHSG. AHSG depleted cell lines are significantly inhibited in their ability to proliferate, adhere, migrate, invade and protect MMP-9. Human AHSG and bovine fetuin-A are functionally equivalent in regards to growth promotion of cancer cell lines.

  5. Analysis of Pretreatment FDG-PET SUV Parameters in Head-and-Neck Cancer: Tumor SUV{sub mean} Has Superior Prognostic Value

    SciTech Connect (OSTI)

    Higgins, Kristin A., E-mail: kristin.higgins@duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Hoang, Jenny K. [Department of Radiology, Division of Neuroradiology, Duke University Medical Center, Durham, NC (United States); Roach, Michael C.; Chino, Junzo; Yoo, David S. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Turkington, Timothy G. [Department of Radiology, Division of Nuclear Medicine, Duke University Medical Center, Durham, NC (United States); Department of Biomedical Engineering, Duke University Medical Center, Durham, NC (United States); Graduate Program in Medical Physics, Duke University Medical Center, Durham, NC (United States); Brizel, David M. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Department of Surgery, Division of Head and Neck Surgery, Duke University Medical Center, Durham, NC (United States)

    2012-02-01T23:59:59.000Z

    Purpose: To evaluate the prognostic significance of different descriptive parameters in head-and-neck cancer patients undergoing pretreatment [F-18] fluoro-D-glucose-positron emission tomography (FDG-PET) imaging. Patients and Methods: Head-and-neck cancer patients who underwent FDG-PET before a course of curative intent radiotherapy were retrospectively analyzed. FDG-PET imaging parameters included maximum (SUV{sub max}), and mean (SUV{sub mean}) standard uptake values, and total lesion glycolysis (TLG). Tumors and lymph nodes were defined on co-registered axial computed tomography (CT) slices. SUV{sub max} and SUV{sub mean} were measured within these anatomic regions. The relationships between pretreatment SUV{sub max}, SUV{sub mean}, and TLG for the primary site and lymph nodes were assessed using a univariate analysis for disease-free survival (DFS), locoregional control (LRC), and distant metastasis-free survival (DMFS). Kaplan-Meier survival curves were generated and compared via the log-rank method. SUV data were analyzed as continuous variables. Results: A total of 88 patients was assessed. Two-year OS, LRC, DMFS, and DFS for the entire cohort were 85%, 78%, 81%, and 70%, respectively. Median SUV{sub max} for the primary tumor and lymph nodes was 15.4 and 12.2, respectively. Median SUV{sub mean} for the primary tumor and lymph nodes was 7 and 5.2, respectively. Median TLG was 770. Increasing pretreatment SUV{sub mean} of the primary tumor was associated with decreased disease-free survival (p = 0.01). Neither SUV{sub max} in the primary tumor or lymph nodes nor TLG was prognostic for any of the clinical endpoints. Patients with pretreatment tumor SUV{sub mean} that exceeded the median value (7) of the cohort demonstrated inferior 2-year DFS relative to patients with SUV{sub mean} {<=} the median value of the cohort, 58% vs. 82%, respectively, p = 0.03. Conclusion: Increasing SUV{sub mean} in the primary tumor was associated with inferior DFS. Although not routinely reported, pretreatment SUV{sub mean} may be a useful prognostic FDG-PET parameter and should be further evaluated prospectively.

  6. Oral Mucositis Prevention By Low-Level Laser Therapy in Head-and-Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy: A Phase III Randomized Study

    SciTech Connect (OSTI)

    Gouvea de Lima, Aline [Departamento de Radiologia, Disciplina de Oncologia, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP (Brazil); Villar, Rosangela Correa [Instituto de Radiologia, Servico de Radioterapia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP (Brazil); Castro, Gilberto de, E-mail: gilberto.castro@usp.br [Department of Clinical Oncology, Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, SP (Brazil); Antequera, Reynaldo [Divisao de Odontologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP (Brazil); Gil, Erlon; Rosalmeida, Mauro Cabral [Instituto de Radiologia, Servico de Radioterapia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP (Brazil); Federico, Miriam Hatsue Honda; Snitcovsky, Igor Moises Longo [Departamento de Radiologia, Disciplina de Oncologia, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP (Brazil)

    2012-01-01T23:59:59.000Z

    Purpose: Oral mucositis is a major complication of concurrent chemoradiotherapy (CRT) in head-and-neck cancer patients. Low-level laser (LLL) therapy is a promising preventive therapy. We aimed to evaluate the efficacy of LLL therapy to decrease severe oral mucositis and its effect on RT interruptions. Methods and Materials: In the present randomized, double-blind, Phase III study, patients received either gallium-aluminum-arsenide LLL therapy 2.5 J/cm{sup 2} or placebo laser, before each radiation fraction. Eligible patients had to have been diagnosed with squamous cell carcinoma or undifferentiated carcinoma of the oral cavity, pharynx, larynx, or metastases to the neck with an unknown primary site. They were treated with adjuvant or definitive CRT, consisting of conventional RT 60-70 Gy (range, 1.8-2.0 Gy/d, 5 times/wk) and concurrent cisplatin. The primary endpoints were the oral mucositis severity in Weeks 2, 4, and 6 and the number of RT interruptions because of mucositis. The secondary endpoints included patient-reported pain scores. To detect a decrease in the incidence of Grade 3 or 4 oral mucositis from 80% to 50%, we planned to enroll 74 patients. Results: A total of 75 patients were included, and 37 patients received preventive LLL therapy. The mean delivered radiation dose was greater in the patients treated with LLL (69.4 vs. 67.9 Gy, p = .03). During CRT, the number of patients diagnosed with Grade 3 or 4 oral mucositis treated with LLL vs. placebo was 4 vs. 5 (Week 2, p = 1.0), 4 vs. 12 (Week 4, p = .08), and 8 vs. 9 (Week 6, p = 1.0), respectively. More of the patients treated with placebo had RT interruptions because of mucositis (6 vs. 0, p = .02). No difference was detected between the treatment arms in the incidence of severe pain. Conclusions: LLL therapy was not effective in reducing severe oral mucositis, although a marginal benefit could not be excluded. It reduced RT interruptions in these head-and-neck cancer patients, which might translate into improved CRT efficacy.

  7. A Planned Neck Dissection Is Not Necessary in All Patients With N2-3 Head-and-Neck Cancer After Sequential Chemoradiotherapy

    SciTech Connect (OSTI)

    Soltys, Scott G., E-mail: sgsoltys@stanford.edu [Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA (United States); Choi, Clara Y.H. [Department of Neurosugery, Stanford University Medical Center, Stanford, CA (United States); Fee, Willard E. [Department of Otolaryngology, Stanford University Medical Center, Stanford, CA (United States); Pinto, Harlan A. [Department of Medical Oncology, Stanford University Medical Center, Stanford, CA (United States); Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA (United States); Le, Quynh-Thu [Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA (United States)

    2012-07-01T23:59:59.000Z

    Purpose: To assess the role of a planned neck dissection (PND) after sequential chemoradiotherapy for patients with head-and-neck cancer with N2-N3 nodal disease. Methods and Materials: We reviewed 90 patients with N2-N3 head-and-neck squamous cell carcinoma treated between 1991 and 2001 on two sequential chemoradiotherapy protocols. All patients received induction and concurrent chemotherapy with cisplatin and 5-fluorocuracil, with or without tirapazamine. Patients with less than a clinical complete response (cCR) in the neck proceeded to a PND after chemoradiation. The primary endpoint was nodal response. Clinical outcomes and patterns of failure were analyzed. Results: The median follow-up durations for living and all patients were 8.3 years (range, 1.5-16.3 year) and 5.4 years (range, 0.6-16.3 years), respectively. Of the 48 patients with nodal cCR whose necks were observed, 5 patients had neck failures as a component of their recurrence [neck and primary (n = 2); neck, primary, and distant (n = 1); neck only (n = 1); neck and distant (n = 1)]. Therefore, PND may have benefited only 2 patients (4%) [neck only failure (n = 1); neck and distant failure (n = 1)]. The pathologic complete response (pCR) rate for those with a clinical partial response (cPR) undergoing PND (n = 30) was 53%. The 5-year neck control rates after cCR, cPR{yields}pCR, and cPR{yields}pPR were 90%, 93%, and 78%, respectively (p = 0.36). The 5-year disease-free survival rates for the cCR, cPR{yields}pCR, and cPR{yields}pPR groups were 53%, 75%, and 42%, respectively (p = 0.04). Conclusion: In our series, patients with N2-N3 neck disease achieving a cCR in the neck, PND would have benefited only 4% and, therefore, is not recommended. Patients with a cPR should be treated with PND. Residual tumor in the PND specimens was associated with poor outcomes; therefore, aggressive therapy is recommended. Studies using novel imaging modalities are needed to better assess treatment response.

  8. Primary Tumor Volume Is an Important Predictor of Clinical Outcomes Among Patients With Locally Advanced Squamous Cell Cancer of the Head and Neck Treated With Definitive Chemoradiotherapy

    SciTech Connect (OSTI)

    Strongin, Anna; Yovino, Susannah [Department of Radiation Oncology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD (United States); Taylor, Rodney; Wolf, Jeffrey [Department of Otorhinolaryngology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD (United States); Cullen, Kevin; Zimrin, Ann [Department of Medical Oncology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD (United States); Strome, Scott [Department of Otorhinolaryngology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD (United States); Regine, William [Department of Radiation Oncology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD (United States); Suntharalingam, Mohan, E-mail: msuntha@umm.edu [Department of Radiation Oncology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD (United States)

    2012-04-01T23:59:59.000Z

    Purpose: The tumor volume has been established as a significant predictor of outcomes among patients with head-and-neck cancer undergoing radiotherapy alone. The present study attempted to add to the existing data on tumor volume as a prognostic factor among patients undergoing chemoradiotherapy. Methods and Materials: A total of 78 patients who had undergone definitive chemoradiotherapy for Stage III-IV squamous cell cancer of the hypopharynx, oropharynx, and larynx were identified. The primary tumor volumes were calculated from the treatment planning computed tomography scans, and these were correlated to the survival and tumor control data obtained from the retrospective analysis. Results: The interval to progression correlated with the primary tumor volume (p = .007). The critical cutoff point for the tumor volume was identified as 35 cm{sup 3}, and patients with a tumor volume <35 cm{sup 3} had a significantly better prognosis than those with a tumor volume >35 cm{sup 3} at 5 years (43% vs. 71%, p = .010). Longer survival was also correlated with smaller primary tumor volumes (p = .022). Similarly, patients with a primary tumor volume <35 cm{sup 3} had a better prognosis in terms of both progression-free survival (61% vs. 33%, p = .004) and overall survival (84% vs. 41%, p = < .001). On multivariate analysis, the primary tumor volume was the best predictor of recurrence (hazard ratio 4.7, 95% confidence interval 1.9-11.6; p = .001) and survival (hazard ratio 10.0, 95% confidence interval 2.9-35.1; p = < .001). In contrast, the T stage and N stage were not significant factors. Analysis of variance revealed that tumors with locoregional failure were on average 21.6 cm{sup 3} larger than tumors without locoregional failure (p = .028) and 27.1-cm{sup 3} larger than tumors that recurred as distant metastases (p = .020). Conclusion: The results of our study have shown that the primary tumor volume is a significant prognostic factor in patients with advanced cancer of the head and neck undergoing definitive chemoradiotherapy and correlated with the treatment outcomes better than the T or N stage.

  9. Define baseline levels of segments per beam for intensity-modulated radiation therapy delivery for brain, head and neck, thoracic, abdominal, and prostate applications

    SciTech Connect (OSTI)

    Sutton, Jordan, E-mail: jsutton@mdanderson.org [University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Kabiru, David; Neu, Michael; Turner, Lehendrick; Balter, Peter; Palmer, Matthew [University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

    2012-04-01T23:59:59.000Z

    The purpose of this study was to evaluate the number of segments per beam for intensity-modulated radiation therapy (IMRT) treatments and its effects on the plan quality, treatment delivery time, machine quality assurance, and machine maintenance. We have retrospectively analyzed 24 patients treated with IMRT. Five were selected within each of the following regions: head and neck, thoracic, abdomen, and prostate. Four patients were optimized within the brain region. The clinically treated plans were re-optimized using Philips Pinnacle3 v. 8 with the direct machine parameter optimization algorithm. The number of segments per beam from the treated plan was systematically reduced by 80%, 60%, 40%, and 30%, and the following statistics have been analyzed for plan quality: target min, mean, and max doses; critical structure doses; and integral dose. We have attempted to define the smallest number of segments per beam for IMRT treatment plans. Results indicate that IMRT plans can be delivered with acceptable quality with approximately 3-6 segments per beam for the anatomical regions analyzed. A reduction in the number of segments decreases treatment delivery time, reduces machine wear and tear, and minimizes the amount of time the patient is on the treatment table, which in turn reduces the chances of intrafractional uncertainties.

  10. Detection of very high energy gamma-ray emission from the Perseus cluster head-tail galaxy IC 310 by the MAGIC telescopes

    E-Print Network [OSTI]

    Aleksi?, J; Antoranz, P; Backes, M; Barrio, J A; Bastieri, D; Gonzlez, J Becerra; Bednarek, W; Berdyugin, A; Berger, K; Bernardini, E; Biland, A; Blanch, O; Bock, R K; Boller, A; Bonnoli, G; Bordas, P; Tridon, D Borla; Bosch-Ramon, V; Bose, D; Braun, I; Bretz, T; Camara, M; Caellas, A; Carmona, E; Carosi, A; Colin, P; Colombo, E; Contreras, J L; Cossio, L; Cortina, J; Covino, S; Dazzi, F; De Angelis, A; del Pozo, E De Cea; De Lotto, B; De Maria, M; De Sabata, F; Mendez, C Delgado; Ortega, A Diago; Doert, M; Domnguez, A; Prester, D Dominis; Dorner, D; Doro, M; Elsaesser, D; Errando, M; Ferenc, D; Fonseca, M V; Font, L; Lpez, R J Garca; Garczarczyk, M; Giavitto, G; Godinovi?, N; Hadasch, D; Herrero, A; Hildebrand, D; Hhne-Mnch, D; Hose, J; Hrupec, D; Jogler, T; Klepser, S; Krhenbhl, T; Kranich, D; Krause, J; La Barbera, A; Leonardo, E; Lindfors, E; Lombardi, S; Longo, F; Lpez, M; Lorenz, E; Majumdar, P; Makariev, M; Maneva, G; Mankuzhiyil, N; Mannheim, K; Maraschi, L; Mariotti, M; Martnez, M; Mazin, D; Meucci, M; Miranda, J M; Mirzoyan, R; Miyamoto, H; Moldn, J; Moralejo, A; Nieto, D; Nilsson, K; Orito, R; Oya, I; Paoletti, R; Paredes, J M; Partini, S; Pasanen, M; Pauss, F; Pegna, R G; Perez-Torres, M A; Persic, M; Peruzzo, L; Pochon, J; Prada, F; Moroni, P G Prada; Prandini, E; Puchades, N; Puljak, I; Reichardt, I; Reinthal, R; Rhode, W; Rib, M; Rico, J; Rgamer, S; Saggion, A; Saito, K; Saito, T Y; Salvati, M; Snchez-Conde, M; Satalecka, K; Scalzotto, V; Scapin, V; Schultz, C; Schweizer, T; Shayduk, M; Shore, S N; Sierpowska-Bartosik, A; Sillanp, A; Sitarek, J; Sobczynska, D; Spanier, F; Spiro, S; Stamerra, A; Steinke, B; Storz, J; Strah, N; Struebig, J C; Suric, T; Takalo, L; Tavecchio, F; Temnikov, P; Terzi?, T; Tescaro, D; Teshima, M; Torres, D F; Vankov, H; Wagner, R M; Weitzel, Q; Zabalza, V; Zandanel, F; Zanin, R; Neronov, A; Pfrommer, C; Pinzke, A; Semikoz, D V

    2015-01-01T23:59:59.000Z

    We report on the detection with the MAGIC telescopes of very high energy gamma-rays from IC 310, a head-tail radio galaxy in the Perseus galaxy cluster, observed during the interval November 2008 to February 2010. The Fermi satellite has also detected this galaxy. The source is detected by MAGIC at a high statistical significance of 7.6sigma in 20.6 hr of stereo data. The observed spectral energy distribution is flat with a differential spectral index of -2.00 \\pm 0.14. The mean flux above 300 GeV, between October 2009 and February 2010, (3.1 \\pm 0.5)x10^{-12} cm^{-2} s^{-1}, corresponds to (2.5 \\pm 0.4)% of Crab Nebula units. Only an upper limit, of 1.9% of Crab Nebula units above 300 GeV, was obtained with the 2008 data. This, together with strong hints (>3sigma) of flares in the middle of October and November 2009, implies that the emission is variable. The MAGIC results favour a scenario with the very high energy emission originating from the inner jet close to the central engine. More complicated models ...

  11. Radiation Therapy Oncology Group Consensus Panel Guidelines for the Delineation of the Clinical Target Volume in the Postoperative Treatment of Pancreatic Head Cancer

    SciTech Connect (OSTI)

    Goodman, Karyn A., E-mail: goodmank@mskcc.org [Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Regine, William F. [University of Maryland School of Medicine, Baltimore, Maryland (United States); Dawson, Laura A. [Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada); Ben-Josef, Edgar [University of Michigan Medical School, Ann Arbor, Michigan (United States); Haustermans, Karin [University Hospital Leuven, Leuven (Belgium); Bosch, Walter R. [Image-Guided Therapy QA Center, Washington University, St. Louis, Missouri (United States); Turian, Julius; Abrams, Ross A. [Rush University Medical College, Chicago, Illinois (United States)

    2012-07-01T23:59:59.000Z

    Purpose: To develop contouring guidelines to be used in the Radiation Therapy Oncology Group protocol 0848, a Phase III randomized trial evaluating the benefit of adjuvant chemoradiation in patients with resected head of pancreas cancer. Methods and Materials: A consensus committee of six radiation oncologists with expertise in gastrointestinal radiotherapy developed stepwise contouring guidelines and an atlas for the delineation of the clinical target volume (CTV) in the postoperative treatment of pancreas cancer, based on identifiable regions of interest and margin expansions. Areas at risk for subclinical disease to be included in the CTV were defined, including nodal regions, anastomoses, and the preoperative primary tumor location. Regions of interest that could be reproducibly contoured on postoperative imaging after a pancreaticoduodenectomy were identified. Standardized expansion margins to encompass areas at risk were developed after multiple iterations to determine the optimal margin expansions. Results: New contouring recommendations based on CT anatomy were established. Written guidelines for the delineation of the postoperative CTV and normal tissues, as well as a Web-based atlas, were developed. Conclusions: The postoperative abdomen has been a difficult area for effective radiotherapy. These new guidelines will help physicians create fields that better encompass areas at risk and minimize dose to normal tissues.

  12. Patterns of Care and Outcomes Associated With Intensity-Modulated Radiation Therapy Versus Conventional Radiation Therapy for Older Patients With Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Yu, James B., E-mail: james.b.yu@yale.edu [Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT (United States); Cancer Outcomes, Public Policy, and Effectiveness Research Center at Yale, New Haven, CT (United States); Soulos, Pamela R. [Cancer Outcomes, Public Policy, and Effectiveness Research Center at Yale, New Haven, CT (United States); Department of Internal Medicine, Yale School of Medicine, New Haven, CT (United States); Sharma, Richa [Duke University School of Medicine, Durham, NC (United States); Makarov, Danil V. [Cancer Outcomes, Public Policy, and Effectiveness Research Center at Yale, New Haven, CT (United States); Department of Urology, New York University School of Medicine, New York, NY (United States); Decker, Roy H. [Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT (United States); Smith, Benjamin D. [Department of Radiation Oncology, M.D. Anderson Cancer Center, Houston, TX (United States); Desai, Rani A. [Yale School of Public Health, New Haven, CT (United States); Robert Wood Johnson Clinical Scholars Program at Yale, New Haven, CT (United States); Cramer, Laura D. [Cancer Outcomes, Public Policy, and Effectiveness Research Center at Yale, New Haven, CT (United States); Department of Internal Medicine, Yale School of Medicine, New Haven, CT (United States); Gross, Cary P. [Cancer Outcomes, Public Policy, and Effectiveness Research Center at Yale, New Haven, CT (United States); Robert Wood Johnson Clinical Scholars Program at Yale, New Haven, CT (United States); Department of Internal Medicine, Yale School of Medicine, New Haven, CT (United States)

    2012-05-01T23:59:59.000Z

    Purpose: Intensity-modulated radiation therapy (IMRT) requires a high degree of expertise compared with standard radiation therapy (RT). We performed a retrospective cohort study of Medicare patients treated with IMRT compared with standard RT to assess outcomes in national practice. Methods and Materials: Using the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database, we identified patients treated with radiation for cancer of the head and neck from 2002 to 2005. We used multivariate Cox models to determine whether the receipt of IMRT was associated with differences in survival. Results: We identified 1613 patients, 33.7% of whom received IMRT. IMRT was not associated with differences in survival: the 3-year overall survival was 50.5% for IMRT vs. 49.6% for standard RT (p = 0.47). The 3-year cancer-specific survival was 60.0% for IMRT vs. 58.8% (p = 0.45). Conclusion: Despite its complexity and resource intensive nature, IMRT use seems to be as safe as standard RT in national community practice, because the use of IMRT did not have an adverse impact on survival.

  13. Subclavian Vein Versus Arm Vein for Totally Implantable Central Venous Port for Patients with Head and Neck Cancer: A Retrospective Comparative Analysis

    SciTech Connect (OSTI)

    Akahane, Akio, E-mail: a.akahane@gmail.com; Sone, Miyuki; Ehara, Shigeru; Kato, Kenichi; Tanaka, Ryoichi; Nakasato, Tatsuhiko [Iwate Medical University School of Medicine, Department of Radiology (Japan)

    2011-12-15T23:59:59.000Z

    Purpose: This study was designed to compare central venous ports (CVP) from two different routes of venous access-the subclavian vein and arm vein-in terms of safety for patients with head and neck cancer (HNC). Methods: Patients with HNC who underwent image-guided implantations of CVPs were retrospectively evaluated. All CVPs were implanted under local anesthesia. Primary outcome measurements were rates and types of adverse events (AEs). Secondary outcomes included technical success and rate and reason of CVP removal. Results: A total of 162 patients (subclavian port group, 47; arm port group, 115) were included in this study. Technical success was achieved in all patients. The median follow-up period was 94 (range, 1-891) days. Two patients in the subclavian port group experienced periprocedural complications. Postprocedural AEs were observed in 8.5 and 22.6% of the subclavian port and arm port group patients, respectively (P = 0.044). Phlebitis and system occlusions were observed only in the arm port group. The rate of infection was not significantly different between the two groups. The CVP was removed in 34 and 39.1% of the subclavian port and arm port patients, respectively. Conclusions: Both subclavian and arm CVPs are feasible in patients with HNC. AEs were more frequent in the arm port group; thus, the arm port is not recommended as the first choice for patients with HNC. However, further experience is needed to improve the placement technique and the maintenance of CVPs and a prospective analysis is warranted.

  14. Initial Results of a Phase I Dose-Escalation Trial of Concurrent and Maintenance Erlotinib and Reirradiation for Recurrent and New Primary Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Rusthoven, Kyle E. [University of Colorado Comprehensive Cancer Center, Aurora, CO (United States); Feigenberg, Steven J. [Fox Chase Cancer Center, Philadelphia, PA (United States); Raben, David; Kane, Madeleine; Song, John I. [University of Colorado Comprehensive Cancer Center, Aurora, CO (United States); Nicolaou, Nicos; Mehra, Ranee; Burtness, Barbara; Ridge, John [Fox Chase Cancer Center, Philadelphia, PA (United States); Swing, Robyn [University of Colorado Comprehensive Cancer Center, Aurora, CO (United States); Lango, Miriam; Cohen, Roger [Fox Chase Cancer Center, Philadelphia, PA (United States); Jimeno, Antonio [University of Colorado Comprehensive Cancer Center, Aurora, CO (United States); Chen Changhu, E-mail: changhu.chen@ucdenver.ed [University of Colorado Comprehensive Cancer Center, Aurora, CO (United States)

    2010-11-15T23:59:59.000Z

    Purpose: To present the first report of a Phase I trial evaluating concurrent and maintenance erlotinib and reirradiation in patients with recurrent or secondary primary head-and-neck cancer (HNC). Methods and Materials: Patients with recurrent or new primary HNC with an interval of at least 6 months since prior radiation were eligible. Patients were treated in 3 sequential cohorts: Cohort I, 100 mg of erlotinib daily with reirradiation at 61.6 Gy in 28 fractions; Cohort II, 150 mg of erlotinib with 61.6 Gy in 28 fractions; and Cohort III, 150 mg of erlotinib with 66 Gy in 30 fractions. Maintenance erlotinib started immediately after reirradiation at 150 mg daily and was continued for 2 years or until disease progression or dose-limiting toxicity. Dose-limiting toxicities were defined as any Grade 4 or 5 toxicity or a toxicity-related delay in radiation therapy of greater than 7 days. Results: Fourteen patients were accrued, 3 to Cohort I, 4 to Cohort II, and 7 to Cohort III. Thirteen patients were evaluable for toxicity. Median follow-up was 8.4 months overall and 15.1 months for surviving patients. One patient had a dose-limiting toxicity in Cohort III. This patient declined initial percutaneous endoscopic gastrostomy tube placement, was hospitalized with Grade 3 dysphagia and aspiration, and required a delay in radiation therapy of greater than 7 days. No Grade 4 acute toxicity was observed. Acute Grade 3 toxicity occurred in 9 of 13 patients. No erlotinib-related toxicity of Grade 3 or greater was observed during maintenance therapy. One patient had Grade 5 carotid hemorrhage 6 months after reirradiation, and another patient had Grade 3 osteoradionecrosis. Conclusions: Reirradiation (66 Gy in 2.2 Gy fractions) with concurrent and maintenance erlotinib (150 mg daily) for recurrent or new primary HNC is feasible.

  15. Feasibility Study of Moderately Accelerated Intensity-Modulated Radiotherapy Plus Concurrent Weekly Cisplatin After Induction Chemotherapy in Locally Advanced Head-and Neck Cancer

    SciTech Connect (OSTI)

    Morganti, Alessio G. [Department of Radiotherapy, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy); Mignogna, Samantha [Department of Palliative Therapies, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy); Deodato, Francesco; Massaccesi, Mariangela [Department of Radiotherapy, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy); Cilla, Savino [Department of Medical Physics, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy); Calista, Franco [Department of Palliative Therapies, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy); Serafini, Giovanni [Department of Head and Neck Surgery, General Hospital, Termoli (Italy); Digesu, Cinzia [Department of Radiotherapy, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy); Macchia, Gabriella, E-mail: gmacchia@rm.unicatt.i [Department of Radiotherapy, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy); Picardi, Vincenzo; Caravatta, Luciana [Department of Radiotherapy, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy); Di Lullo, Liberato [Department of Oncology, General Hospital, Isernia (Italy); Giglio, Gianfranco [Department of Oncology, General Hospital, Campobasso (Italy); Sallustio, Giuseppina [Department of Radiology, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy); Piermattei, Angelo [Department of Medical Physics, 'John Paul II' Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy)

    2011-03-15T23:59:59.000Z

    Purpose: To evaluate the feasibility and efficacy of moderately accelerated intensity-modulated radiation therapy (IMRT) along with weekly cisplatin, after induction chemotherapy, in patients with locally advanced unresectable head and neck cancer (HNC). Methods and Materials: Patients with Stage III or IV locally advanced HNC, without progressive disease after three courses of induction chemotherapy, received concurrent chemo-IMRT (weekly cisplatin 30 mg/m{sup 2} plus simultaneous integrated boost IMRT). A total of 67.5 Gy in 30 fractions were delivered to primary tumor and involved nodes, 60 Gy in 30 fractions to high-risk nodal areas, and 55.5 Gy in 30 fractions to low-risk nodal areas. Results: In all, 36 patients (median age, 56 years) with International Union Against Cancer (UICC) Stage III (n = 5) and IV (n = 31) were included. Of the 36 patients, 17 had received CF (cisplatin and 5-fluorouracil (CF) and 19 had received docetaxel cisplatin and 5-fluorouracil (DCF). During concurrent chemoradiation, 11 of 36 patients (30.5%) experienced Grade III mucositis (CF, 47%; DCF, 15%; p < 0.04). Grade III pharyngeal-esophageal toxicity was observed in 5 of 19 patients (26.3%; CF, 0.0%; DCF, 26.3%; p = 0.02). Two patients died of complications (5.5%). After chemoradiation, the complete response rate was 63.8%. Two-year local control was 88.7%. Two-year progression free survival and overall survival were 74.5% and 60.9%, respectively. Conclusions: In our experience, a moderately accelerated chemo-IMRT was feasible after induction chemotherapy. However, a noteworthy early death rate of 5.5% was observed. Intensive supportive care strategies should be defined to better manage radiation-induced toxic effects. Longer follow-up is required to determine the incidence of late radiation toxicities and tumor control rates.

  16. Analysis of Vision Loss Caused by Radiation-Induced Optic Neuropathy After Particle Therapy for Head-and-Neck and Skull-Base Tumors Adjacent to Optic Nerves

    SciTech Connect (OSTI)

    Demizu, Yusuke, E-mail: y_demizu@nifty.co [Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Murakami, Masao; Miyawaki, Daisuke; Niwa, Yasue [Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Akagi, Takashi [Department of Accelerator Managing, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Sasaki, Ryohei [Division of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Terashima, Kazuki [Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Suga, Daisaku [Department of Radiation Technology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Kamae, Isao [Division of Medical Statistics, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Hishikawa, Yoshio [Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan)

    2009-12-01T23:59:59.000Z

    Purpose: To assess the incident rates of vision loss (VL; based on counting fingers or more severe) caused by radiation-induced optic neuropathy (RION) after particle therapy for tumors adjacent to optic nerves (ONs), and to evaluate factors that may contribute to VL. Methods and Materials: From August 2001 to August 2006, 104 patients with head-and-neck or skull-base tumors adjacent to ONs were treated with carbon ion or proton radiotherapy. Among them, 145 ONs of 75 patients were irradiated and followed for greater than 12 months. The incident rate of VL and the prognostic factors for occurrence of VL were evaluated. The late effects of carbon ion and proton beams were compared on the basis of a biologically effective dose at alpha/beta = 3 gray equivalent (GyE{sub 3}). Results: Eight patients (11%) experienced VL resulting from RION. The onset of VL ranged from 17 to 58 months. The median follow-up was 25 months. No significant difference was observed between the carbon ion and proton beam treatment groups. On univariate analysis, age (>60 years), diabetes mellitus, and maximum dose to the ON (>110 GyE{sub 3}) were significant, whereas on multivariate analysis only diabetes mellitus was found to be significant for VL. Conclusions: The time to the onset of VL was highly variable. There was no statistically significant difference between carbon ion and proton beam treatments over the follow-up period. Based on multivariate analysis, diabetes mellitus correlated with the occurrence of VL. A larger study with longer follow-up is warranted.

  17. The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro

    SciTech Connect (OSTI)

    Li, Qiang; Song, Xin-mao; Ji, Yang-yang; Jiang, Hui; Xu, Lin-gen, E-mail: drlingenxu@126.com

    2013-11-01T23:59:59.000Z

    Highlights: AZD8055 induces significant cytotoxic effects in cultured HNSCC cells. AZD8055 blocks mTORC1 and mTORC2 activation in cultured HNSCC cells. JNK activation is required for AZD8055-induced HNSCC cell death. AZD8055 inhibits Hep-2 cell growth in vivo, and was more efficient than rapamycin. -- Abstract: The serine/threonine kinase mammalian target of rapamycin (mTOR) promotes cell survival and proliferation, and is constitutively activated in head and neck squamous cell carcinoma (HNSCC). Thus mTOR is an important target for drug development in this disease. Here we tested the anti-tumor ability of AZD8055, the novel mTOR inhibitor, in HNSCC cells. AZD8055 induced dramatic cell death of HNSCC lines (Hep-2 and SCC-9) through autophagy. AZD8055 blocked both mTOR complex (mTORC) 1 and mTORC2 activation without affecting Erk in cultured HNSCC cells. Meanwhile, AZD8055 induced significant c-Jun N-terminal kinase (JNK) activation, which was also required for cancer cell death. JNK inhibition by its inhibitors (SP 600125 and JNK-IN-8), or by RNA interference (RNAi) alleviated AZD8055-induced cell death. Finally, AZD8055 markedly increased the survival of Hep-2 transplanted mice through a significant reduction of tumor growth, without apparent toxicity, and its anti-tumor ability was more potent than rapamycin. Meanwhile, AZD8055 administration activated JNK while blocking mTORC1/2 in Hep-2 tumor engrafts. Our current results strongly suggest that AZD8055 may be further investigated for HNSCC treatment in clinical trials.

  18. Arsenic-induced alteration in intracellular calcium homeostasis induces head kidney macrophage apoptosis involving the activation of calpain-2 and ERK in Clarias batrachus

    SciTech Connect (OSTI)

    Banerjee, Chaitali [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Goswami, Ramansu [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Centre for Environmental Studies, Visva-Bharati University, Santiniketan 731 235 (India); Datta, Soma [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Rajagopal, R. [Gut Biology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Mazumder, Shibnath, E-mail: shibnath1@yahoo.co.in [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India)

    2011-10-01T23:59:59.000Z

    We had earlier shown that exposure to arsenic (0.50 {mu}M) caused caspase-3 mediated head kidney macrophage (HKM) apoptosis involving the p38-JNK pathway in Clarias batrachus. Here we examined the roles of calcium (Ca{sup 2+}) and extra-cellular signal-regulated protein kinase (ERK), the other member of MAPK-pathway on arsenic-induced HKM apoptosis. Arsenic-induced HKM apoptosis involved increased expression of ERK and calpain-2. Nifedipine, verapamil and EGTA pre-treatment inhibited the activation of calpain-2, ERK and reduced arsenic-induced HKM apoptosis as evidenced from reduced caspase-3 activity, Annexin V-FITC-propidium iodide and Hoechst 33342 staining. Pre-incubation with ERK inhibitor U 0126 inhibited the activation of calpain-2 and interfered with arsenic-induced HKM apoptosis. Additionally, pre-incubation with calpain-2 inhibitor also interfered with the activation of ERK and inhibited arsenic-induced HKM apoptosis. The NADPH oxidase inhibitor apocynin and diphenyleneiodonium chloride also inhibited ERK activation indicating activation of ERK in arsenic-exposed HKM also depends on signals from NADPH oxidase pathway. Our study demonstrates the critical role of Ca{sup 2+} homeostasis on arsenic-induced HKM apoptosis. We suggest that arsenic-induced alteration in intracellular Ca{sup 2+} levels initiates pro-apoptotic ERK and calpain-2; the two pathways influence each other positively and induce caspase-3 mediated HKM apoptosis. Besides, our study also indicates the role of ROS in the activation of ERK pathway in arsenic-induced HKM apoptosis in C. batrachus. - Highlights: > Altered Ca{sup 2+} homeostasis leads to arsenic-induced HKM apoptosis. > Calpain-2 plays a critical role in the process. > ERK is pro-apoptotic in arsenic-induced HKM apoptosis. > Arsenic-induced HKM apoptosis involves cross talk between calpain-2 and ERK.

  19. Comparison of 2D Radiographic Images and 3D Cone Beam Computed Tomography for Positioning Head-and-Neck Radiotherapy Patients

    SciTech Connect (OSTI)

    Li Heng [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Zhu, X. Ronald [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)], E-mail: xrzhu@mdanderson.org; Zhang Lifei; Dong Lei; Tung, Sam [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Ahamad, Anesa M.D.; Chao, K. S. Clifford; Morrison, William H.; Rosenthal, David I.; Schwartz, David L. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Mohan, Radhe [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Garden, Adam S. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

    2008-07-01T23:59:59.000Z

    Purpose: To assess the positioning accuracy using two-dimensional kilovoltage (2DkV) imaging and three-dimensional cone beam CT (CBCT) in patients with head and neck (H and N) cancer receiving radiation therapy. To assess the benefit of patient-specific headrest. Materials and Methods: All 21 patients studied were immobilized using thermoplastic masks with either a patient-specific vacuum bag (11 of 21, IMA) or standard clear plastic (10 of 21, IMB) headrests. Each patient was imaged with a pair of orthogonal 2DkV images in treatment position using onboard imaging before the CBCT procedure. The 2DkV and CBCT images were acquired weekly during the same session. The 2DkV images were reviewed by oncologists and also analyzed by a software tool based on mutual information (MI). Results: Ninety-eight pairs of assessable 2DkV-CBCT alignment sets were obtained. Systematic and random errors were <1.6 mm for both 2DkV and CBCT alignments. When we compared shifts determined by CBCT and 2DkV for the same patient setup, statistically significant correlations were observed in all three major directions. Among all CBCT couch shifts, 4.1% {>=} 0.5 cm and 18.7% {>=} 0.3 cm, whereas among all 2DkV (MI) shifts, 1.7% {>=} 0.5 cm and 11.2% {>=} 0.3 cm. Statistically significant difference was found on anteroposterior direction between IMA and IMB with the CBCT alignment only. Conclusions: The differences between 2D and 3D alignments were mainly caused by the relative flexibility of certain H and N structures and possibly by rotation. Better immobilization of the flexible neck is required to further reduce the setup errors for H and N patients receiving radiotherapy.

  20. Pretreatment Apparent Diffusion Coefficient of the Primary Lesion Correlates With Local Failure in Head-and-Neck Cancer Treated With Chemoradiotherapy or Radiotherapy

    SciTech Connect (OSTI)

    Hatakenaka, Masamitsu, E-mail: mhatake@radiol.med.kyushu-u.ac.jp [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka City (Japan); Nakamura, Katsumasa; Yabuuchi, Hidetake; Shioyama, Yoshiyuki; Matsuo, Yoshio; Ohnishi, Kayoko; Sunami, Shunya; Kamitani, Takeshi; Setoguchi, Taro; Yoshiura, Takashi [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka City (Japan); Nakashima, Torahiko [Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka City (Japan); Nishikawa, Kei [Radiology Center, Kyushu University Hospital, Kyushu University, Fukuoka City (Japan); Honda, Hiroshi [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka City (Japan)

    2011-10-01T23:59:59.000Z

    Purpose: This study was performed to evaluate whether the apparent diffusion coefficient (ADC) of a primary lesion correlates with local failure in primary head-and-neck squamous cell carcinoma (HNSCC) treated with chemoradiotherapy or radiotherapy. Methods and Materials: We retrospectively studied 38 patients with primary HNSCC (12 oropharynx, 20 hypopharynx, 4 larynx, 2 oral cavity) treated with chemoradiotherapy or radiotherapy with radiation dose to gross tumor volume equal to or over 60 Gy and who underwent pretreatment magnetic resonance imaging, including diffusion-weighted imaging. Ten patients developed local failure during follow-up periods of 2.0 to 9.3 months, and the remaining 28 showed local control during follow-up periods of 10.5 to 31.7 months. The variables that could affect local failure (age, tumor volume, ADC, T stage, N stage, dose, treatment method, tumor location, and overall treatment time) were analyzed using logistic regression analyses for all 38 patients and for 17 patients with Stage T3 or T4 disease. Results: In univariate logistic analysis for all 38 cases, tumor volume, ADC, T stage, and treatment method showed significant (p < 0.05) associations with local failure. In multivariate analysis, ADC and T stage revealed significance (p < 0.01). In univariate logistic analysis for the 17 patients with Stage T3 or T4 disease, ADC and dose showed significant (p < 0.01) associations with local failure. In multivariate analysis, ADC alone showed significance (p < 0.05). Conclusions: The results suggest that pretreatment ADC, along with T stage, is a potential indicator of local failure in HNSCC treated with chemoradiotherapy or radiotherapy.

  1. Comparison of Physical Examination and Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 4-6 Months After Radiotherapy to Assess Residual Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Zundel, M. Tracy [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Michel, Michelle A. [Department of Radiology, Medical College of Wisconsin, Milwaukee, WI (United States); Schultz, Christopher J. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Maheshwari, Mohit [Department of Radiology, Medical College of Wisconsin, Milwaukee, WI (United States); Wong, Stuart J. [Department of Neoplastic and Related Disorders, Medical College of Wisconsin, Milwaukee, WI (United States); Campbell, Bruce H.; Massey, Becky L.; Blumin, Joel [Department of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI (United States); Wilson, J. Frank [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Wang, Dian, E-mail: dwang@mcw.edu [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)

    2011-12-01T23:59:59.000Z

    Purpose: To retrospectively compare fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and physical examination 4-6 months after radiotherapy for assessing residual head-and-neck cancer (HNC). Methods and Materials: From July 2002 through March 2006, 52 HNC patients underwent definitive radiotherapy or chemoradiotherapy. Categoric assessments of residual tumor by PET/CT and physical examination 4-6 months after therapy were correlated and compared with clinical outcomes. Pretreatment data, including tumor stage and primary site standardized uptake value, were also gathered retrospectively and correlated with clinical outcomes. Median follow-up time was 58 months. Results: Twenty-one patients had either locoregionally 'positive' (17 of 21) or 'equivocal' (4 of 21) PET/CT scans, whereas 31 patients had locoregionally negative scans. Four patients failed treatment and had biopsy-confirmed residual or recurrent local disease. All patients, including patients with locally suspicious scans or examinations who refused biopsies, were followed clinically for a minimum of 29 months after therapy, with no other cases of treatment failure detected during this time. No patient had residual nodal disease after therapy. Sensitivities of PET/CT vs. physical examination for early detection of treatment failure were 100% vs. 50%, whereas the specificities of the two modalities were 64.6% vs. 89.6%, respectively. Higher initial T stage and American Joint Commission on Cancer stage correlated with increased incidence of positive/equivocal PET/CT results and treatment failure. Maximal standardized uptake value was not predictive of any clinical outcome. Conclusions: A negative result on PET/CT obtained 4-6 months after radiotherapy is highly sensitive and correlates with successful locoregional control. Patients with negative scans may reasonably be spared invasive diagnostic procedures, such as biopsy and neck dissection, unless recurrent disease is suspected on clinical grounds. Close follow-up is prudent for HNC patients with abnormal findings on posttherapy PET/CT scan.

  2. Integrating Epidermal Growth Factor Receptor Assay With Clinical Parameters Improves Risk Classification for Relapse and Survival in Head-and-Neck Squamous Cell Carcinoma

    SciTech Connect (OSTI)

    Chung, Christine H., E-mail: cchung11@jhmi.edu [Division of Hematology/Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (United States); Zhang Qiang [RTOG Statistical Center, Philadelphia, PA (United States); Hammond, Elizabeth M. [LDS Hospital, Salt Lake City, UT (United States); Trotti, Andy M. [H. Lee Moffitt Cancer Center, Tampa, FL (United States); Wang Huijun [University of Texas MD Anderson Cancer Center, Houston, TX (United States); Spencer, Sharon [University of Alabama at Birmingham Medical Center, Birmingham, AL (United States); Zhang Huazhong [University of Texas MD Anderson Cancer Center, Houston, TX (United States); Cooper, Jay [New York University Hospital, New York, NY (United States); Maimonides Cancer Center, Brooklyn, NY (United States); Jordan, Richard [University of California, San Francisco, CA (United States); Rotman, Marvin H. [SUNY Health Science Center Brooklyn, Brooklyn, NY (United States); Ang, K. Kian [University of Texas MD Anderson Cancer Center, Houston, TX (United States)

    2011-10-01T23:59:59.000Z

    Purpose: Epidermal growth factor receptor (EGFR) overexpression has been consistently found to be an independent predictor of local-regional relapse (LRR) after radiotherapy. We assessed the extent by which it can refine risk classification for overall survival (OS) and LRR in patients with head-and-neck squamous cell carcinoma (HNSCC). Methods and Materials: EGFR expression in locally advanced HNSCC was measured by immunohistochemistry in a series of patients randomized to receive accelerated or conventional radiation regimens in a Phase III trial. Subsequently, data of the two series were pooled (N = 533) for conducting a recursive partitioning analysis that incorporated clinical parameters (e.g., performance status, primary site, T and N categories) and four molecular markers (EGFR, p53, Ki-67, and microvessel density). Results: This study confirmed that patients with higher than median levels of tumor EGFR expression had a lower OS (relative risk [RR]: 1.90, p = 0.0010) and a higher LRR (RR: 1.91, p = 0.0163). Of the four markers analyzed, only EGFR was found to contribute to refining classification of patients into three risk classes with distinct OS and LRR outcomes. The addition of EGFR to three clinical parameters could identify patients having up to a fivefold difference in the risk of LRR. Conclusions: Adding pretreatment EGFR expression data to known robust clinical prognostic variables improved the estimation of the probability for OS and LRR after radiotherapy. Its use for stratifying or selecting patients with defined tumor feature and pattern of relapse for enrollment into clinical trials testing specific therapeutic strategy warrants further investigation.

  3. The Role of Computed Tomography in the Management of the Neck After Chemoradiotherapy in Patients With Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Clavel, Sebastien, E-mail: sebastien.clavel@umontreal.ca [Department of Radiation Oncology, Centre hospitalier de l'Universite de Montreal, Montreal, Quebec (Canada); Charron, Marie-Pierre [Faculte de medicine, Universite de Montreal, Montreal, Quebec (Canada); Belair, Manon [Department of Radiology, Centre hospitalier de l'Universite de Montreal, Montreal, Quebec (Canada); Delouya, Guila; Fortin, Bernard; Despres, Philippe [Department of Radiation Oncology, Centre hospitalier de l'Universite de Montreal, Montreal, Quebec (Canada); Soulieres, Denis [Department of Medical Oncology, Centre hospitalier de l'Universite de Montreal, Montreal, Quebec (Canada); Filion, Edith [Department of Radiation Oncology, Centre hospitalier de l'Universite de Montreal, Montreal, Quebec (Canada); Guertin, Louis [Department of Head and Neck Surgery, Centre hospitalier de l'Universite de Montreal, Montreal, Quebec (Canada); and others

    2012-02-01T23:59:59.000Z

    Purpose: The aim of this study was to describe the outcome in patients with head-and neck-squamous cell carcinoma (HNSCC) followed up without neck dissection (ND) after concomitant chemoradiotherapy (CRT) based on computed tomography (CT) response. The second objective was to establish CT characteristics that can predict which patients can safely avoid ND. Methods and Materials: Between 1998 and 2007, 369 patients with node-positive HNSCC were treated with primary CRT at our institution. After a clinical and a radiologic evaluation based on CT done 6 to 8 weeks after CRT, patients were labeled with a complete neck response (CR) or with a partial neck response (PR). Results: The median follow-up was 44 months. The number of patients presenting with N3, N2, or N1 disease were 54 (15%), 268 (72%), and 47 (13%), respectively. After CRT, 263 (71%) patients reached a CR, and 253 of them did not undergo ND. Ninety-six patients reached a PR and underwent ND. Of those, 34 (35%) had residual disease on pathologic evaluation. A regression of the diameter of {>=}80% and a residual largest diameter of 15 mm of nodes had negative pathologic predictive values of 100% and 86%, respectively. The 3-year regional control and survival rates were not different between patients with CR who had no ND and patients with PR followed by ND. Conclusion: Node-positive patients presenting a CR as determined by CT evaluation 6 to 8 weeks after CRT had a low rate of regional recurrence without ND. This study also suggests that lymph node residual size and percentage of regression on CT after CRT may be useful criteria to guide clinical decisions regarding neck surgery. Those results can help diminish the number of ND procedures with negative results and their associated surgical complications.

  4. Department Heads Meeting: May 20, 2010 1 Department Heads Meeting

    E-Print Network [OSTI]

    Wechsler, Risa H.

    technology with broad application across OS ­ Low cost compact acceleration applications such as storage ring injectors, light source drivers, compact linacs for security, industry and medicine · Core capability in rf technology options beyond cold-rf for ILC ­ Pursue ALC warm x-band rf technologies of benefit to both HEP

  5. Head-to-Head Comparison of Serum Fractionation Techniques. |...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    comparison of several serum fractionation schemes, including N-linked glycopeptide enrichment, cysteinyl-peptide enrichment, magnetic bead separation (C3, C8, and WCX), size...

  6. Department Administration Year Department Head

    E-Print Network [OSTI]

    Velev, Orlin D.

    Director of Undergraduate Studies Graduate Administrator Machine Shop 1924-1925 Edgar Randolph 1925-1926 Edgar Randolph 1926-1927 Edgar Randolph 1927-1928 Edgar Randolph 1928-1929 Edgar Randolph 1929-1930 Edgar Randolph Lois Todd 1930-1931 Edgar Randolph Lois Todd 1931-1932 Edgar Randolph Lois Todd 1932

  7. Temporal Nodal Regression and Regional Control After Primary Radiation Therapy for N2-N3 Head-and-Neck Cancer Stratified by HPV Status

    SciTech Connect (OSTI)

    Huang, Shao Hui; O'Sullivan, Brian [Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario (Canada); Xu, Wei; Zhao, Helen [Department of Biostatistics, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario (Canada); Chen, Duo-duo [Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Ringash, Jolie; Hope, Andrew [Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario (Canada); Razak, Albiruni [Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Gilbert, Ralph; Irish, Jonathan [Department of Otolaryngology-Head and Neck Surgery/Surgical Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario (Canada); Kim, John; Dawson, Laura A.; Bayley, Andrew; Cho, B.C. John [Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario (Canada); Goldstein, David; Gullane, Patrick [Department of Otolaryngology-Head and Neck Surgery/Surgical Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario (Canada); Yu, Eugene [Department of Radiology, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Perez-Ordonez, Bayardo; Weinreb, Ilan [Department of Pathology, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Waldron, John, E-mail: John.Waldron@rmp.uhn.on.ca [Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario (Canada)

    2013-12-01T23:59:59.000Z

    Purpose: To compare the temporal lymph node (LN) regression and regional control (RC) after primary chemoradiation therapy/radiation therapy in human papillomavirus-related [HPV(+)] versus human papillomavirus-unrelated [HPV(?)] head-and-neck cancer (HNC). Methods and Materials: All cases of N2-N3 HNC treated with radiation therapy/chemoradiation therapy between 2003 and 2009 were reviewed. Human papillomavirus status was ascertained by p16 staining on all available oropharyngeal cancers. Larynx/hypopharynx cancers were considered HPV(?). Initial radiologic complete nodal response (CR) (?1.0 cm 8-12 weeks after treatment), ultimate LN resolution, and RC were compared between HPV(+) and HPV(?) HNC. Multivariate analysis identified outcome predictors. Results: A total of 257 HPV(+) and 236 HPV(?) HNCs were identified. The initial LN size was larger (mean, 2.9 cm vs 2.5 cm; P<.01) with a higher proportion of cystic LNs (38% vs 6%, P<.01) in HPV(+) versus HPV(?) HNC. CR was achieved is 125 HPV(+) HNCs (49%) and 129 HPV(?) HNCs (55%) (P=.18). The mean post treatment largest LN was 36% of the original size in the HPV(+) group and 41% in the HPV(?) group (P<.01). The actuarial LN resolution was similar in the HPV(+) and HPV(?) groups at 12 weeks (42% and 43%, respectively), but it was higher in the HPV(+) group than in the HPV(?) group at 36 weeks (90% vs 77%, P<.01). The median follow-up period was 3.6 years. The 3-year RC rate was higher in the HPV(?) CR cases versus non-CR cases (92% vs 63%, P<.01) but was not different in the HPV(+) CR cases versus non-CR cases (98% vs 92%, P=.14). On multivariate analysis, HPV(+) status predicted ultimate LN resolution (odds ratio, 1.4 [95% confidence interval, 1.1-1.7]; P<.01) and RC (hazard ratio, 0.3 [95% confidence interval 0.2-0.6]; P<.01). Conclusions: HPV(+) LNs involute more quickly than HPV(?) LNs but undergo a more prolonged process to eventual CR beyond the time of initial assessment at 8 to 12 weeks after treatment. Post radiation neck dissection is advisable for all non-CR HPV(?)/non-CR N3 HPV(+) cases, but it may be avoided for selected non-CR N2 HPV(+) cases with a significant LN involution if they can undergo continued imaging surveillance. The role of positron emission tomography for response assessment should be investigated.

  8. SU-E-J-229: Quantitative Assessment for Timely Adaptive Re-Planning Using Weekly Dose Monitoring for Head and Neck Cancer

    SciTech Connect (OSTI)

    Shang, Q; Liu, H; Greskovich, J; Koyfman, S; Xia, P [Cleveland Clinic, Cleveland, OH (United States); Li, Z [Cleveland Clinic, Cleveland, OH (United States); the 6th people's hospital of Shanghai Jiaotong University, Shanghai, Shanghai (China)

    2014-06-01T23:59:59.000Z

    Purpose: For patients with head and neck (HN) cancer, mid-course adaptive radiation therapy (ART) is a common practice in our institution to accommodate anatomic changes. The aim of the study is to evaluate whether dose re-calculation on weekly verification images can provide quantitative assessment for timely adaptive re-planning with daily image-guided intensity modulated radiotherapy (IMRT). Methods: We retrospectively selected sixty daily verification images acquired on CT-on-rail/CBCT from ten HN patients. These image sets were typically a week apart. Among these patients, six patients received a mid-course ART. Contours of the tumors and organ-at-risks (OARs) were manually delineated by a physician on each verification CT. After placing the treatment iso-center on the verification CTs according to the recorded clinical shifts, daily dose was re-calculated with the same beam configuration as the original plan. For the purpose of this study, electron densities for both verification CTs and planning CTs were set to 1.0 g/cm3. Results: Two patients had D99 of the CTV < 97% of the planned dose for more than three fractions due to remarkable tumor volume shrinkages. D-max of the spinal cord exceeded a tolerance of 45 Gy for four fractions in additional two patients. D-mean of the parotid increased within 25% of the planned value. D-max of the brainstem and D-mean of the oral cavity did not show significant variation. If the re-planning criteria included D99 of the CTV < 97% of the planned dose and D-max of the spinal cord > 45 Gy, two out ten patients required ART at week 2 and two patients required ART at week 3, respectively. Conclusion: Weekly dose monitoring with re-calculation on verification images can provide quantitative dose guidance for timely adaptive re-planning. Future work will include accumulative dose analysis for the decision of adaptive re-planning. The study is supported in part by Siemens Medical Solutions.

  9. Smolt Monitoring at the Head of Lower Granite Reservoir and Lower Granite Dam; Smolt Monitoring by Federal and Non-Federal Entities, 2001-2002 Annual Report.

    SciTech Connect (OSTI)

    Buettner, Edwin W.; Putnam, Scott A.

    2003-06-01T23:59:59.000Z

    This project monitored the daily passage of chinook salmon Oncorhynchus tshawytscha, steelhead trout O. mykiss, and sockeye salmon smolts O. nerka during the 2001 spring out-migration at migrant traps on the Snake River and Salmon River. In 2001 fish management agencies released significant numbers of hatchery chinook salmon and steelhead trout above Lower Granite Dam that were not marked with a fin clip or coded-wire tag. Generally, these fish were distinguishable from wild fish by the occurrence of fin erosion. Total annual hatchery chinook salmon catch at the Snake River trap was 11% of the 2000 numbers. The wild chinook catch was 3% of the previous year's catch. Hatchery steelhead trout catch was 49% of 2000 numbers. Wild steelhead trout catch was 69% of 2000 numbers. The Snake River trap collected 28 age-0 chinook salmon. During 2001 the Snake River trap captured zero hatchery and zero wild/natural sockeye salmon and six hatchery coho salmon O. kisutch. Differences in trap catch between years are due to fluctuations not only in smolt production, but also differences in trap efficiency and duration of trap operation associated with flow. The significant reduction in catch during 2001 was due to a reduction in hatchery chinook production (60% of 2000 release) and due to extreme low flows. Trap operations began on March 11 and were terminated on June 29. The trap was out of operation for a total of two days due to mechanical failure or debris. Hatchery chinook salmon catch at the Salmon River trap was 47% and wild chinook salmon catch was 67% of 2000 numbers. The hatchery steelhead trout collection in 2001 was 178% of the 2000 numbers. Wild steelhead trout collection in 2001 was 145% of the previous year's catch. Trap operations began on March 11 and were terminated on June 8 due to the end of the smolt monitoring season. There were no days where the trap was out of operation due to high flow or debris. The decrease in hatchery chinook catch in 2001 was due to a reduction in hatchery production (39% of 2000 releases). The increase in hatchery and wild steelhead trap catch is due to the ability to operate the trap in the thalweg for a longer period of time because of the extreme low flow condition in 2001. Travel time (d) and migration rate (km/d) through Lower Granite Reservoir for PIT-tagged chinook salmon and steelhead trout marked at the head of the reservoir were affected by discharge. There were not enough hatchery and wild chinook salmon tagged at the Snake River trap in 2001 to allow migration rate/discharge analysis. For steelhead trout tagged at the Snake River trap, statistical analysis of 2001 data detected a significant relation between migration rate and Lower Granite Reservoir inflow discharge. For hatchery and wild steelhead trout, there was a 2.2-fold and a 1.5-fold increase in migration rate in, respectively, between 50 and 100 kcfs. Travel time and migration rate to Lower Granite Dam for fish marked at the Salmon River trap were calculated. Statistical analysis of the 2001 data detected a significant relation between migration rate and Lower Granite Reservoir inflow discharge for hatchery and wild chinook salmon and hatchery and wild steelhead trout. Migration rate increased 3.7-fold for hatchery chinook salmon and 2.5-fold for wild chinook salmon between 50 and 100 kcfs. For hatchery steelhead there was a 1.6-fold increase in migration rate, and for wild steelhead trout there was a 2.2-fold increase between 50 kcfs and 100 kcfs. Fish tagged with passive integrated transponder (PIT) tags at the Snake River trap were interrogated at four dams with PIT tag detection systems (Lower Granite, Little Goose, Lower Monumental, and McNary dams). Because of the addition of the fourth interrogation site (Lower Monumental) in 1993, cumulative interrogation data is not comparable with the prior five years (1988-1992). Cumulative interrogations at the four dams for fish marked at the Snake River trap were 86% for hatchery chinook, 70% for wild chinook, 71% for hatchery steelhead, and 89% for wild steelhead. Cumulat

  10. Multi-institutional Quantitative Evaluation and Clinical Validation of Smart Probabilistic Image Contouring Engine (SPICE) Autosegmentation of Target Structures and Normal Tissues on Computer Tomography Images in the Head and Neck, Thorax, Liver, and Male Pelvis Areas

    SciTech Connect (OSTI)

    Zhu, Mingyao [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Bzdusek, Karl [Philips Healthcare, Fitchburg, Wisconsin (United States); Brink, Carsten [Institute of Clinical Research, University of Southern Denmark, Odense (Denmark); Laboratory of Radiation Physics, Odense University Hospital, Odense (Denmark); Eriksen, Jesper Grau [Department of Oncology, Odense University Hospital, Odense (Denmark); Hansen, Olfred [Institute of Clinical Research, University of Southern Denmark, Odense (Denmark); Department of Oncology, Odense University Hospital, Odense (Denmark); Jensen, Helle Anita [Department of Oncology, Odense University Hospital, Odense (Denmark); Gay, Hiram A.; Thorstad, Wade [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Widder, Joachim; Brouwer, Charlotte L.; Steenbakkers, Roel J.H.M.; Vanhauten, Hubertus A.M. [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Cao, Jeffrey Q.; McBrayne, Gail [London Regional Cancer Centre, Ontario (Canada); Patel, Salil H. [Department of Radiation Oncology, Rhode Island Hospital, Providence, Rhode Island (United States); Cannon, Donald M. [Department of Human Oncology, University of WisconsinMadison (United States); Hardcastle, Nicholas [Department of Physical Science, Peter MacCallum Cancer Centre, Melbourne (Australia); Tom, Wolfgang A. [Montefiore Medical Center and Institute of Onco-Physics, Albert Einstein College of Medicine, Bronx, New York (United States); Guckenberg, Matthias [University of Wrzburg, Department of Radiation Oncology, Wrzburg (Germany); Parikh, Parag J., E-mail: pparikh@radonc.wustl.edu [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States)

    2013-11-15T23:59:59.000Z

    Purpose: Clinical validation and quantitative evaluation of computed tomography (CT) image autosegmentation using Smart Probabilistic Image Contouring Engine (SPICE). Methods and Materials: CT images of 125 treated patients (32 head and neck [HN], 40 thorax, 23 liver, and 30 prostate) in 7 independent institutions were autosegmented using SPICE and computational times were recorded. The number of structures autocontoured were 25 for the HN, 7 for the thorax, 3 for the liver, and 6 for the male pelvis regions. Using the clinical contours as reference, autocontours of 22 selected structures were quantitatively evaluated using Dice Similarity Coefficient (DSC) and Mean Slice-wise Hausdorff Distance (MSHD). All 40 autocontours were evaluated by a radiation oncologist from the institution that treated the patients. Results: The mean computational times to autosegment all the structures using SPICE were 3.1 to 11.1 minutes per patient. For the HN region, the mean DSC was >0.70 for all evaluated structures, and the MSHD ranged from 3.2 to 10.0 mm. For the thorax region, the mean DSC was 0.95 for the lungs and 0.90 for the heart, and the MSHD ranged from 2.8 to 12.8 mm. For the liver region, the mean DSC was >0.92 for all structures, and the MSHD ranged from 5.2 to 15.9 mm. For the male pelvis region, the mean DSC was >0.76 for all structures, and the MSHD ranged from 4.8 to 10.5 mm. Out of the 40 autocontoured structures reviews by experts, 25 were scored useful as autocontoured or with minor edits for at least 90% of the patients and 33 were scored useful autocontoured or with minor edits for at least 80% of the patients. Conclusions: Compared with manual contouring, autosegmentation using SPICE for the HN, thorax, liver, and male pelvis regions is efficient and shows significant promise for clinical utility.

  11. Assessment of biological communities at Rame Head

    E-Print Network [OSTI]

    ) compared to the two stations located at a greater distance from the disposal site (G8 and G28) in all years 10 20 30 40 50 60 70 g8 g18 g16 g13 g19 g3 g28 0 50 100 150 200 250 300 350 g8 g18 g16 g13 g19 g3 g28 D E O G3A02 G8A02 G18B02 G16A01 G19B03 G13A03 G19A03 G19C03 G13B03 G13C03 G3A01 G3B02 G3A03 G3B03 G3

  12. ESnet Update Steve Cotter, Dept Head

    E-Print Network [OSTI]

    Requirements Workshops Capacity (Science Data > Planned ESnet capacity growth) Multiple 100G links by 2015 Increased commodity Internet peering Increased capacity for private peering Services Differentiated services-HUB 1 Infinera DTC chassis installed (Dec 2010) NEWY-HUB 3 Infinera DTC Chassis installed (Dec 2010

  13. MEMORANDUM FOR HEADS OF DEPARTMENTAL ELEMENTS FROM:

    Energy Savers [EERE]

    e t Request On July 18,2008, the Secretary approved the Department's Contract and Project Management Root Cause Analysis (RCA) Corrective Action Plan (CAP). This is the...

  14. On Heads and Coordination in Valence Acquisition

    E-Print Network [OSTI]

    Przepirkowski, Adam

    to be useful also for many other purposes. A. Gelbukh (Ed.): CICLing 2007, LNCS 4394, pp. 5061, 2007. c

  15. NEWSLETTER December 2012 Head of School Report

    E-Print Network [OSTI]

    Wagner, Stephan

    of mineral resources by securing for themselves careers in the mining sector have been rudely awakened `gone global'. Looking forward, the next IGC, in 2016, will be held in Africa for the first time

  16. H. Jonathan Chao ECE Dept Head

    E-Print Network [OSTI]

    Aronov, Boris

    are growing rapidly 100k ­ 1M servers in a single facility · How to build a large-scale data center Erkip Yao Wang Zhong-Ping Jiang Spencer Kuo Shivendra Panwar #12;4 Books Published by ECE Professors · Books by Prof. Jonathan Chao #12;5 Books Published by ECE Professors · Books by Prof. Theodore Rappaport

  17. Thomas Elton Furtak Professor and Head

    E-Print Network [OSTI]

    - engagement teaching methods at all levels, through course delivery reforms since 1992. In particular, Prof

  18. Electro-optical voltage sensor head

    DOE Patents [OSTI]

    Woods, Gregory K. (Idaho Falls, ID)

    1998-01-01T23:59:59.000Z

    A miniature electro-optic voltage sensor system capable of accurate operation at high voltages. The system employs a transmitter, a sensor disposed adjacent to but out of direct electrical contact with a conductor on which the voltage is to be measured, a detector, and a signal processor. The transmitter produces a beam of electromagnetic radiation which is routed into the sensor where the beam undergoes the Pockels electro-optic effect. The electro-optic effect causes phase shifting in the beam, which is in turn converted to a pair of independent beams, from which the voltage of a system based on its E-field is determined when the two beams are normalized by the signal processor. The sensor converts the beam by splitting the beam in accordance with the axes of the beam's polarization state (an ellipse whose ellipticity varies between -1 and +1 in proportion to voltage) into at least two AM signals. These AM signals are fed into a signal processor and processed to determine the voltage between a ground conductor and the conductor on which voltage is being measured.

  19. William Milsom eception/Head S

    E-Print Network [OSTI]

    Wood, Spencer

    -3373 2-3291 Page 1 of 5 ogy Contac -2131 Fax 604 ROOM/L BioScience BioScience BioScience BioScience Bio

  20. Heading into the Amendment Process: Hydrosystem Mitigation

    E-Print Network [OSTI]

    reforms: Implementation of l ll d t d h t h iti ti lllegally mandated hatchery mitigation, as well uncertainties. Standardized metrics, protocols, reporting and HLIs are being adopted. A number of reforms

  1. Dr FABIO RIGAT Research Biostatistics Group Head,

    E-Print Network [OSTI]

    Goldschmidt, Christina

    theory, model uncertainty and model selection in dynamic settings, construction of context-specific utility functions, semi-parametric dynamic models and sequential learning, survival analysis, MCMC methods, USA). Thesis: "Beta Stacy Survival Models and Bayesian Weibull Survival Trees". (www

  2. Organic Trends Where are we headed??

    E-Print Network [OSTI]

    -20 ? Spelt 18-27 cents / lb ? Dry Beans $65 - 70 / cwt #12;Costs of Production 2009 Corn Soybeans Winter minerals Enhance water infiltration & holding capacity Enhance root penetration Secrete plant growth soil diseases Detoxify soils Increase water and nutrient uptake #12;Lime Materials Calcitic

  3. MEMORANDUM FOR HEADS OF DEPARTMENTAL ELEMENTS FROM:

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking ofOil & Gas »ofMarketing |Prepare For26, 2015 MEETINGComments*^

  4. Mars mission laser tool heads to JPL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |IsLove Your Home and It'llMappingMariaHereldMars mission laser tool

  5. Assessing the feasibility of volumetric-modulated arc therapy using simultaneous integrated boost (SIB-VMAT): An analysis for complex head-neck, high-risk prostate and rectal cancer cases

    SciTech Connect (OSTI)

    Cilla, Savino, E-mail: savinocilla@gmail.com [Medical Physics Unit, Fondazione di ricerca e cura Giovanni Paolo II, Universit Cattolica del Sacro Cuore, Campobasso (Italy); Deodato, Francesco; Diges, Cinzia; Macchia, Gabriella; Picardi, Vincenzo; Ferro, Marica [Radiation Oncology Unit, Fondazione di ricerca e cura Giovanni Paolo II, Universit Cattolica del Sacro Cuore, Campobasso (Italy); Sallustio, Giuseppina [Radiology Unit, Fondazione di ricerca e cura Giovanni Paolo II, Universit Cattolica del Sacro Cuore, Campobasso (Italy); De Spirito, Marco; Piermattei, Angelo [Physics Institute, Universit Cattolica del Sacro Cuore, Rome (Italy); Morganti, Alessio G. [Radiation Oncology Unit, Fondazione di ricerca e cura Giovanni Paolo II, Universit Cattolica del Sacro Cuore, Campobasso (Italy)

    2014-04-01T23:59:59.000Z

    Intensity-modulated radiotherapy (IMRT) allowed the simultaneous delivery of different doses to different target volumes within a single fraction, an approach called simultaneous integrated boost (SIB). As consequence, the fraction dose to the boost volume can be increased while keeping low doses to the elective volumes, and the number of fractions and overall treatment time will be reduced, translating into better radiobiological effectiveness. In recent years, volumetric-modulated arc therapy (VMAT) has been shown to provide similar plan quality with respect to fixed-field IMRT but with large reduction in treatment time and monitor units (MUs) number. However, the feasibility of VMAT when used with SIB strategy has few investigations to date. We explored the potential of VMAT in a SIB strategy for complex cancer sites. A total of 15 patients were selected, including 5 head-and-neck, 5 high-risk prostate, and 5 rectal cancer cases. Both a double-arc VMAT and a 7-field IMRT plan were generated for each case using Oncentra MasterPlan treatment planning system for an Elekta Precise linac. Dosimetric indexes for targets and organs at risk (OARs) were compared based on dose-volume histograms. Conformity index, homogeneity index, and dose-contrast index were used for target analyses. The equivalent uniform doses and the normal tissue complication probabilities were calculated for main OARs. MUs number and treatment time were analyzed to score treatment efficiency. Pretreatment dosimetry was performed using 2-dimensional (2D)-array dosimeter. SIB-VMAT plans showed a high level of fluence modulation needed for SIB treatments, high conformal dose distribution, similar target coverage, and a tendency to improve OARs sparing compared with the benchmark SIB-IMRT plans. The median treatment times reduced from 13 to 20 minutes to approximately 5 minutes for all cases with SIB-VMAT, with a MUs reduction up to 22.5%. The 2D-array ion-chambers' measurements reported an agreement of more than 95% for a criterion of 3% to 3 mm. SIB-VMAT was able to combine the advantages of conventional SIB-IMRT with its highly conformal dose distribution and OARs sparing and the advantages of 3D-conformal radiotherapy with its fast delivery.

  6. Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging With {sup 1}H Magnetic Resonance Spectroscopy, Dynamic Contrast-Enhanced MRI, and [{sup 18}F]FDG-PET

    SciTech Connect (OSTI)

    Jansen, Jacobus F.A. [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Radiology, Maastricht University Medical Center, Maastricht (Netherlands); Schoeder, Heiko [Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Lee, Nancy Y. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Stambuk, Hilda E. [Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wang Ya [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Fury, Matthew G. [Department of Medical Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Patel, Senehal G. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Pfister, David G. [Department of Medical Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Shah, Jatin P. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Koutcher, Jason A. [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Medical Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Shukla-Dave, Amita, E-mail: davea@mskcc.org [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

    2012-01-01T23:59:59.000Z

    Purpose: To correlate proton magnetic resonance spectroscopy ({sup 1}H-MRS), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and {sup 18}F-labeled fluorodeoxyglucose positron emission tomography ([{sup 18}F]FDG PET) of nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) for assessment of tumor biology. Additionally, pretreatment multimodality imaging was evaluated for its efficacy in predicting short-term response to treatment. Methods and Materials: Metastatic neck nodes were imaged with {sup 1}H-MRS, DCE-MRI, and [{sup 18}F]FDG PET in 16 patients with newly diagnosed HNSCC, before treatment. Short-term patient radiological response was evaluated at 3 to 4 months. Correlations among {sup 1}H-MRS (choline concentration relative to water [Cho/W]), DCE-MRI (volume transfer constant [K{sup trans}]; volume fraction of the extravascular extracellular space [v{sub e}]; and redistribution rate constant [k{sub ep}]), and [{sup 18}F]FDG PET (standard uptake value [SUV] and total lesion glycolysis [TLG]) were calculated using nonparametric Spearman rank correlation. To predict short-term responses, logistic regression analysis was performed. Results: A significant positive correlation was found between Cho/W and TLG ({rho} = 0.599; p = 0.031). Cho/W correlated negatively with heterogeneity measures of standard deviation std(v{sub e}) ({rho} = -0.691; p = 0.004) and std(k{sub ep}) ({rho} = -0.704; p = 0.003). Maximum SUV (SUVmax) values correlated strongly with MRI tumor volume ({rho} = 0.643; p = 0.007). Logistic regression indicated that std(K{sup trans}) and SUVmean were significant predictors of short-term response (p < 0.07). Conclusion: Pretreatment multimodality imaging using {sup 1}H-MRS, DCE-MRI, and [{sup 18}F]FDG PET is feasible in HNSCC patients with nodal metastases. Additionally, combined DCE-MRI and [{sup 18}F]FDG PET parameters were predictive of short-term response to treatment.

  7. Usefulness of Interim FDG-PET After Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Sequential Induction Chemotherapy Followed by Concurrent Chemoradiotherapy

    SciTech Connect (OSTI)

    Yoon, Dok Hyun; Cho, Yoojin [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Kim, Sang Yoon; Nam, Soon Yuhl; Choi, Seung-Ho; Roh, Jong-Lyel [Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Lee, Sang-wook; Song, Si Yeol [Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Lee, Jeong Hyun [Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Kim, Jae Seung [Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Cho, Kyung-Ja [Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Kim, Sung-Bae, E-mail: sbkim3@amc.seoul.kr [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2011-09-01T23:59:59.000Z

    Purpose: Induction chemotherapy (ICT) has been used to select patients for organ preservation and determine subsequent treatments in patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN). Still, the clinical outcomes of LASCCHN patients who showed response to ICT are heterogeneous. We evaluated the efficacy of interim 18-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) after ICT in this specific subgroup of LASCCHN patients who achieved partial response (PR) after ICT to predict clinical outcomes after concurrent chemoradiotherapy (CCRT). Methods and Materials: Twenty-one patients with LASCCHN who showed PR to ICT by Response Evaluation Criteria In Solid Tumors before definitive CCRT were chosen in this retrospective analysis. FDG-PET was performed before and 2-4 weeks after ICT to assess the extent of disease at baseline and the metabolic response to ICT, respectively. We examined the correlation of the metabolic response by the percentage decrease of maximum standardized uptake value (SUVmax) on the primary tumor or lymph node after ICT or a specific threshold of SUVmax on interim FDG-PET with clinical outcomes including complete response (CR) rate to CCRT, progression-free survival (PFS), and overall survival (OS). Results: A SUVmax of 4.8 on interim FDG-PET could predict clinical CR after CCRT (100% vs. 20%, p = 0.001), PFS (median, not reached vs. 8.5 mo, p < 0.001), and OS (median, not reached vs. 12.0 months, p = 0.001) with a median follow-up of 20.3 months in surviving patients. A 65% decrease in SUVmax after ICT from baseline also could predict clinical CR after CCRT (100% vs. 33.3%, p = 0.003), PFS (median, not reached vs. 8.9 months, p < 0.001) and OS (median, not reached vs. 24.4 months, p = 0.001) of the patients. Conclusion: These data suggest that interim FDG-PET after ICT might be a useful determinant to predict clinical outcomes in patients with LASCCHN receiving sequential ICT followed by CCRT.

  8. Electronic Supplement to Chapter 4 Photos of Individual Heads File (.JPG) Head Date* Time* Photographer Notes

    E-Print Network [OSTI]

    Desbrun, Mathieu

    _3063 LDL-5 2007/07/12 11:41:45 AM LDL-5_3065 LDL-5 2007/07/12 11:42:29 AM LNG-1_1739 LNG-1 2005/06/01 15:15:56 DN LNG-1_1740 LNG-1 2005/06/01 15:16:09 DN LNG-1_1741 LNG-1 2005/06/01 15:16:20 DN LNG-1_0301 LNG-1 2006/06/09 12:13:56 AM LNG-1_0304 LNG-1 2006/06/09 12:14:35 AM LNG-1_0309 LNG-1 2006/06/09 12:16:25 AM

  9. PPA Department Heads: Dec 17, 2009 Page 1 Department Heads Meeting

    E-Print Network [OSTI]

    Wechsler, Risa H.

    .D. only Job Title AD LCLS PPA PSD SSRL Total Associate Staff Scientist 1 3 5 9 Staff Scientist 32 7 26 2 with LCLS performance & transition to user operations Applauds superb ongoing achievement by Fermi plan for accelerator R&D Update on LCLS science and plans for managing user demand Plans

  10. December 1, 2011 To: Deans, Directors, and Department Heads

    E-Print Network [OSTI]

    requests to expand an existing service contract or, if you feel it is absolutely necessary, to engage a new

  11. Virgil: Objects on the Head of a Pin

    E-Print Network [OSTI]

    Titzer, B L

    2006-01-01T23:59:59.000Z

    Intrinsics are library code and types, other thanis generic types [8], which will allow library designers toapplications and libraries with interfaces. Parametric types

  12. Virgil: Objects on the Head of a Pin

    E-Print Network [OSTI]

    Titzer, B L

    2006-01-01T23:59:59.000Z

    to store than an index into a compression table, the indexedindex, a savings of 75% over storing a 16-bit address. The compressioncompression table. In this approach, each compressed reference is an object handle: an integer index

  13. 2010 RAL Space Head, Space Engineering &Technology Division

    E-Print Network [OSTI]

    into the solar wind; thermite reaction; ionized by solar radiation; hoped to trace ions down to CCE in lower

  14. HPV & head and neck cancer: a descriptive update

    E-Print Network [OSTI]

    Goon, Peter K C; Stanley, Margaret A; Ebmeyer, Jorg; Steinstraesser, Lars; Upile, Tahwinder; Jerjes, Waseem; Bernal-Sprekelsen, Manuel; Gorner, Martin; Sudhoff, Holger H

    2009-10-14T23:59:59.000Z

    the manuscript. MS, LS, TU, WJ and MBS critically revised the manuscript. References 1. Parkin DM, Bray F: Chapter 2: The burden of HPV-related can- cers. Vaccine 2006, 24(Suppl 3):11-25. 2. Mignogna MD, Fedele S, Lo Russo L: The World Cancer Report...

  15. Department of Energy Contractor Diana Lewis Heading to National...

    Broader source: Energy.gov (indexed) [DOE]

    of small business that contract with the federal government every year. Diana Lewis, a West Virginia native and founder of Action Facilities Management, Inc., is one of the...

  16. Head-on impact of liquid drops Robert D. Schroll

    E-Print Network [OSTI]

    Zhang, Wendy

    ) ]1/2 U0 impact speed 1 m/s C speed of sound 1500 m/s Us variation ! liquid ejected radially ! = radius / impact speed impact time-scale #12;Deformation Dominated by Inertia volume conservation ! pressure variation ! liquid ejected radially ! = radius / impact speed

  17. Using doppler radar images to estimate aircraft navigational heading error

    DOE Patents [OSTI]

    Doerry, Armin W. (Albuquerque, NM); Jordan, Jay D. (Albuquerque, NM); Kim, Theodore J. (Albuquerque, NM)

    2012-07-03T23:59:59.000Z

    A yaw angle error of a motion measurement system carried on an aircraft for navigation is estimated from Doppler radar images captured using the aircraft. At least two radar pulses aimed at respectively different physical locations in a targeted area are transmitted from a radar antenna carried on the aircraft. At least two Doppler radar images that respectively correspond to the at least two transmitted radar pulses are produced. These images are used to produce an estimate of the yaw angle error.

  18. Home > News & Events HEAD OF THE CLASS: Physics

    E-Print Network [OSTI]

    Toback, David

    Mechanics Scholars. The students, selected for their top-scoring marks on a special end winners, visit http://faculty.physics.tamu.edu/toback/MechanicsScholar/. -aTm- Contact: Chris Jarvis, (979) 845-7246 or cjarvis@science.tamu.edu Jarvis Chris 2011-05-05 00:00:00 About Us | Site Map | Privacy

  19. Head/disk interface tribology in the nanometer regime

    E-Print Network [OSTI]

    Xu, Jianfeng

    2008-01-01T23:59:59.000Z

    disks with different surface topography. No single transferFigure 7.5 Disk surface topography measured using atomicwith different surface topography. Thus, surface topography

  20. Energy Savings from Floating Head Pressure in Ammonia Refrigeration Systems

    E-Print Network [OSTI]

    Barrer, P. J.; Jones, S. M.

    plant, based on a model incorporating manufacturer's published compressor efficiency and evaporative condenser capacity and energy use as it varies with outdoor wetbulb temperature. It concludes with a simple control strategy for effectively retrofitting...

  1. Dual-headed SPECT for awake animal brain imaging

    SciTech Connect (OSTI)

    S. Lee, B. Kross, D. Weisenberger, J. McKisson, J.S. Goddard, J.S. Baba, M.S. Smith

    2012-02-01T23:59:59.000Z

    Motion-corrected awake animal imaging is needed for normal-state investigations of models of neurological disease and brain activity. The awake animal brain SPECT/CT system, AwakeSPECT at Johns Hopkins University has in the past used a single gamma camera for imaging. Enhancements have been made by adding a pinhole collimator to the second gamma camera at the opposite side which has been previously equipped parallel hole collimator. Geometry calibration was performed using a custom built quality control phantom containing three Co-57 point sources and applied to the tomographic reconstruction code. Hot-rod phantom scans with Tc-99m were performed to test sensitivity and resolution improvements. The reconstruction results show significant resolution and sensitivity improvements.

  2. Student Pages Diamond Head Tuff Ring Field Study

    E-Print Network [OSTI]

    Hammer, Julia Eve

    or steam. Tuff cones range in size from 60 to 2000 m (200 to 6,500 feet) across and from 10 to 200 m (30 conduit. The fragments may be held tightly together by cementing material, creating a rock you can break pattern; if the unit appears to be layered, indicate these with lines. If the units have distinctive

  3. Valley, Ames teams headed for National Science Bowl | The Ames...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    school event will have 50 teams. Valley will be represented by Gabriel Mintzer, Ryan Thompson, Charles Napier, Sunita Kolareth and Arun Velamuri and coached by Nate Speichinger....

  4. Los Alamos names new head of stockpile manufacturing and support

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    technology division and then the engineering division, responsible for high explosive manufacturing and testing operations and engineering support for all weapons assembly and...

  5. AUV technology heads for new depths[Autonomous Underwater Vehicle

    SciTech Connect (OSTI)

    Hayes, D.

    2000-04-01T23:59:59.000Z

    High-tech unmanned submarine technologies initially developed by the US Navy are being adapted for a new role to assist the oil and gas industry's shift into deeper waters. To address the problem of costly data acquisition and inaccurate survey data, C and C Technologies of Lafayette, La., has hired Kongsberg Simrad to construct the Hugin 3000 deepwater autonomous underwater vehicle (AUV). As the technology is applied to energy exploration and production advances to meet the deepwater challenges beyond the continental shelf, AUVs will be increasingly employed, it is believed. The paper describes the Hugin project, unexpected situations, the vehicle position tracking system, vehicle operation and real-time data quality control, real-time data monitoring and control, Hugin field experience, and pipe route surveying.

  6. F A C U L T Y DIVISION HEAD

    E-Print Network [OSTI]

    Gering, Jon C.

    , Daniel Hite, Elisabeth Hooper, Diane Janick- Buckner, Brian Lamp, Ian M. Lindevald, Michael L. Lockhart faculty lectures, small group recitations, student-led dis- cussions, presentations, and investigative

  7. UNITED STATES: NOAA Head Vows to Protect Marine Re-

    E-Print Network [OSTI]

    , Cameron, La., in Volume Washington-Oregon Salmon Pack Rose Sharp- ly 1971 Gulf Menhaden Catch Sets Record Japanese Mothership Salmon Fishery Means Research for NMFS Gravel System Holds Promise for Salmon Fry

  8. Beyond the Head: The Practical Work of Curating Contemporary Art

    E-Print Network [OSTI]

    Acord, Sophia Krzys

    2010-01-01T23:59:59.000Z

    son exposition. Paris: LHarmattan. Calhoun, C. , & Sennett,symbolique. Paris: LHarmattan. DeNora, T. (2000). Music in

  9. Incremental adaptation to yaw head movements during 30 RPM centrifugation

    E-Print Network [OSTI]

    Elias, Paul Z. (Paul Ziad)

    2006-01-01T23:59:59.000Z

    Artificial Gravity (AG) provided by short-radius centrifugation is a promising countermeasure against the harmful physiological effects of prolonged weightlessness. However, the vestibular stimulus associated with making ...

  10. Barbara Nolan, European Commission, Head of Unit Higher Education

    E-Print Network [OSTI]

    Viglas, Anastasios

    in lifelong learning #12;The Bologna Process - content Shared Agenda between 46 countries Bologna reforms Dimension #12;EU Modernisation Agenda Governance reform autonomy and accountability Funding reform diversified funding mechanisms Curricula reform the Bologna Process #12;EU programmes and initiatives

  11. Retiree Heads Back to Work, Helps Families Stay Afloat

    Broader source: Energy.gov [DOE]

    Mark Morris of South Bend, Ind., is among many in the country who were already retired, but whose 401(k) account took a big hit when the stock market crashed. Mark had retired as a utility-company supervisor in mid-2007, but he lost 40 percent of his retirement money and knew he had to go back to work.

  12. Intimate Partner Violence 1 Running head: INTIMATE PARTNER VIOLENCE

    E-Print Network [OSTI]

    Reber, Paul J.

    theoretical analyses of the phenomenon (Dobash & Dobash, 1979; Straus, Gelles, & Steinmetz, 1980). Since

  13. NATIONAL CONTEXT AND Robin Clegg, Head of Science in Society

    E-Print Network [OSTI]

    pa of taxpayers' money · Support for Govt Science & Innovation Agenda (especially, the STEM strategy for this type of work (basic science, facilities, energy research, etc) Clegg & Edmunds, STFC Town Meeting 30 November 2007 #12;DRIVERS 2 · Also note overlap with Corporate Communications strategy · For example

  14. Accurate 100:1 Rangeability Linear Response Head Meter

    E-Print Network [OSTI]

    Grant, G. H.

    from the Eighth Annual Industrial Energy Technology Conference, Houston, TX, June 17-19, 1986 for mass flow unitsKo for volumetric flow unitsKo The validity of the above has been confirmed by tests carried out by an independent flow laboratory which...Ifio under the new conditions. (U. S. Energy Department Steam Flmv Heasurement nay 1985). The Gilflo is unusually insensitive to asymmetric swirling velocity profiles as can be seen froD the chart which gives the % difference between reading obtained...

  15. Supplement 15, Parasite-Subject Catalogue, Subject Headings, Treatment

    E-Print Network [OSTI]

    Humphrey, Judith M.; Segal, Dorothy B.; Beard, Mary I.; Edwards, Shirley J.; Kirby, Margie D.

    1966-01-01T23:59:59.000Z

    of roundworms of cattle in Wyoming Anemia Foote, L. E.; Hansard, S. L.; anaplasmosis and Parker, J., I962 a Anemia Foy, H.; and Nelson, G. S., etiology in tropics 19?? a ? helminths Anaemia, Human Heinivaara, 0.; and Kaipainen, bone marrow studies in W. J... contortus; Trichostrongylus colubriformis; T. spp.; T. axei; Oesophagostomum radiatum; Fasciola hep- ?tica; Hypoderma spp.; ?stertagia spp.; 0. venulosum; Chabertia ovina; Amblyomma triguttatum; Nematodirus spp.; A. queenslandensis; A. ornatissimum; A...

  16. Beyond the Head: The Practical Work of Curating Contemporary Art

    E-Print Network [OSTI]

    Acord, Sophia Krzys

    2010-01-01T23:59:59.000Z

    The University of Chicago Press. Sophia Krzys Acord recentlyof Curating Contemporary Art Sophia Krzys Acord Published

  17. Raft River monitor well potentiometric head responses and water...

    Open Energy Info (EERE)

    wells that are sampled one season cannot be sampled the next. In addition, information on well construction, completion, and production is often unreliable or not available. These...

  18. Numerical and experimental investigations of the head/disk interface

    E-Print Network [OSTI]

    Duwensee, Maik

    2007-01-01T23:59:59.000Z

    Graphics, User Manual. [9] The MathWorks, Inc. Matlab: Instrument ControlGraphics, User Manual. [9] The MathWorks, Inc. Matlab: Instrument Control

  19. MEMORANDUM FOR HEADS OF DEPARTMENTAL ELEMENTS OTHER THAN THE

    Broader source: Energy.gov (indexed) [DOE]

    the bi-weekly pay limitation for employees who are engaged in any type of emergency response activity including, but not limited to, disaster relief assistance, radiological...

  20. abusive head trauma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    care problem of epidemic proportions. In addition to the immediate trauma caused by abuse, domestic violence contributes to a number of chronic health problems, Biotechnology...

  1. Zone Clinical Department Head Dr. G. MacQueen

    E-Print Network [OSTI]

    Calgary, University of

    &A Acute Care Serv & Children's Day Treatment Program Dr. Waheed ACH Mood & Anxiety Clinic Dr. Rodway Young Rehabilitation Vacant FMC Mental Health Day Treatment Dr. Oluwadairo Shared Mental Health Care Dr. Oakander FMC Addictions & Claresholm Dr. Colohan Claresholm Care Centre Dr. Colohan Addictions Network Dr. Lim Addiction

  2. FALL 2014 GSIs Delwiche, Ian 7A HEAD GSI

    E-Print Network [OSTI]

    Budker, Dmitry

    , Alex 129 Lee, Juwon 137A.1 Gee, David 137A.2 Cheung, Kolen 137A.3 Schillaci, Cory 137B.1 Haouzi, Nathan

  3. New Director Heads Actuarial Science Program - Department of ...

    E-Print Network [OSTI]

    Sally

    2002-01-03T23:59:59.000Z

    It includes more career information as well as the current (new) plan .... Above, Actuarial Science Advisory Council members Chris Ruckman. (B.S. mathematics

  4. F A C U L T Y DIVISION HEAD

    E-Print Network [OSTI]

    Gering, Jon C.

    Master of Arts, MA UNDERGRADUATE MAJORS Communication Disorders Exercise Science Health Science Nursing H and Performance is home for disciplines that focus on Applied Life Sciences. Each degree program is grounded in liberal arts and sciences that serve as the foundations for content studied within the major. Communica-tion

  5. Intelligent head-down display design for the smart cockpit

    E-Print Network [OSTI]

    Branham, Paul Anthony

    1998-01-01T23:59:59.000Z

    ) Display Mode . . . . . . . . . . . . . . . . . . . . 13 Moving Map Symbology Set. 14 Automatic Scaling Flowchart 15 Check Lists (CHCK LSTS) Display Mode 16 Training (TRNG) Display Mode. 17 Built-in Self Test (BIT) Display Mode. 18 GAPATS Executive...), and other NavAids, with the plane's current location represented on the screen by an icon. ~ Flight Planning - A standardized display format is used which permits the pilot to quickly enter data in a logical order, generally corresponding with an FAA...

  6. Cooling Boiling in Head Region - PACCAR Integrated Underhood...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Integrated External Aerodynamic and Underhood Thermal Analysis for Heavy Vehicles CRADA with PACCAR Experimental Investigation in Coolant Boiling in a Half-Heated Circular...

  7. T U R ECATALOGUE 2013 Head of School Introduction

    E-Print Network [OSTI]

    Banaji,. Murad

    ) Stage 2 Architecture BA (Hons) Stage 1 Architecture PhD Research MSc Architecture and Sustainable MArch Unit 1 Unit 2 Unit 3 Unit 4 BA (Hons) Stage 3 Architecture BA (Hons) Stage 3 Interiors BA (Hons of Architecture Catalogue 2013 `Kent School of Architecture has been ranked 6th in the 2014 Guardian University

  8. Zeroth-order inversion of transient head observations

    E-Print Network [OSTI]

    Vasco, D.W.

    2008-01-01T23:59:59.000Z

    rocks, Water Resour. Res. , Petrol. Res. , Jacquard, P. ,tical implications, Soc. Petrol. Eng. Journal, Cohen, J.

  9. Deterministic hazard quotients (HQs): Heading down the wrong road

    SciTech Connect (OSTI)

    Wilde, L.; Hunter, C.; Simpson, J. [Golder Associates Inc., Redmond, WA (United States)

    1995-12-31T23:59:59.000Z

    The use of deterministic hazard quotients (HQs) in ecological risk assessment is common as a screening method in remediation of brownfield sites dominated by total petroleum hydrocarbon (TPH) contamination. An HQ {ge} 1 indicates further risk evaluation is needed, but an HQ {le} 1 generally excludes a site from further evaluation. Is the predicted hazard known with such certainty that differences of 10% (0.1) do not affect the ability to exclude or include a site from further evaluation? Current screening methods do not quantify uncertainty associated with HQs. To account for uncertainty in the HQ, exposure point concentrations (EPCs) or ecological benchmark values (EBVs) are conservatively biased. To increase understanding of the uncertainty associated with HQs, EPCs (measured and modeled) and toxicity EBVs were evaluated using a conservative deterministic HQ method. The evaluation was then repeated using a probabilistic (stochastic) method. The probabilistic method used data distributions for EPCs and EBVs to generate HQs with measurements of associated uncertainty. Sensitivity analyses were used to identify the most important factors significantly influencing risk determination. Understanding uncertainty associated with HQ methods gives risk managers a more powerful tool than deterministic approaches.

  10. Interim Department Head Academic Advisor/Graduate Coordinator

    E-Print Network [OSTI]

    Holliday, Vance T.

    /repair of mass spectrometers 6. Chemistry and general research support Ben McElhaney Electrical Technician (0. Graduate student support 2. Undergraduate student support, Field Camp 3. Funding, scholarships, TA's, & RA

  11. Forest Enterprise Scotland Head Office 1 Highlander Way

    E-Print Network [OSTI]

    #12;2 Scotland'sNationalForestEstate2013-2016 The role of Scotland's National Forest Estate Commission Picture Library unless otherwise stated. Designed by Whitenoise Creative for Forestry Commission of Forestry Commission Scotland charged with managing the National Forest Estate. Scotland's National Forest

  12. EM's Los Alamos TRU Waste Campaign Heads Toward Completion | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:RevisedAdvisory Board Contributions EMEM Recovery ActSeries |ofEnvironment

  13. Top information officer will also head technology (Daily Press) | Jefferson

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool of tomorrowChemCamInnovation |

  14. Memorandum for Heads of Federal Departments and Agencies: Emergencies...

    Energy Savers [EERE]

    the Council on Environmental Quality reiterates its previous guidance on the National Environmental Policy Act (NEPA) environmental review of proposed emergency response...

  15. Date: April 6, 2006 To: Deans, Directors, and Department Heads

    E-Print Network [OSTI]

    Buehrer, R. Michael

    , and administrative areas were involved in the evaluation of the SciQuest products. Their reaction was positive in order to improve the efficiency and effectiveness of our business and administrative processes, and I am environment. Recently, the University enacted a contract with a company named SciQuest for the implementation

  16. Sprinkler Head Replacement (4586), 4/24/2012

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over Our Instagram Secretary900 Special Report:Spotlight: Bryantis here April 15,

  17. DOE Head of Contracting Activity and Procurement Directors' Directory - May

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsNovember 13, 2014ContributingDOE Contract #DEAC13-02GJ794912Guidance7Special26,

  18. Head of EM Visits Northwest Tribes | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy ChinaofSchaefer To:Department of Energy Completing theWhiz! |Nearly six weeks HazleEM

  19. TO: Procurement Directors Head of Contracting Activities FROM: Director

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23, 2014,ZaleskiThis Decision considers anExercise32 DATE: June 17,1096149 DATE:

  20. New Theory Head to join PPPL | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible for Renewable Energy:Nanowire Solar541,9337, 2011R -ElectrodesDepartment ofReturning

  1. Katie Antypas Named New Head of NERSC User Services Department

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your Home as ReadyAppointed to National AcademiesKatie Antypas

  2. LANL names new head of Nuclear and High Hazard Operations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your Home as ReadyAppointedKyungmin2010 top corporate

  3. LANL names new head of Plutonium Science and Manufacturing

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your Home as ReadyAppointedKyungmin2010 top corporateJeff

  4. Laurie Bagley succeeds Lew Meixler as head of Technology Transfer |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your HomeLatest News Releases Tribune carriesLaura Lauren

  5. Los Alamos National Laboratory names new head of weapons programs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is YourAwards Pollution Prevention

  6. DOE Head of Contracting Activity and Procurement Directors' Directory - May

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube| Department of Energy -StateOffshoreFuelCleanup10 AllDOE H2ADOE HQ) Go

  7. TO: Procurement Directors Head of Contracting Activities FROM: Director

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof Energy 2, 2015 - January 16, 2015Meetings TEC MeetingsTITLE 48 CHAPTER5 DATE:95-08

  8. Cooling Boiling in Head Region - PACCAR Integrated Underhood Thermal and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: Theof"Wave theJuly 30, 2013 Sanyo:MarchPracticesPresentation from theExternal

  9. Cylinder Head Gasket with Integrated Combustion Pressure Sensors |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: Theof"Wave theJuly 30,Crafty Gifts|Energy Cybersecurity

  10. Tracking Santa: An Interview with the Head Researcher | Department of

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23,EnergyChicopeeTechnologyfact sheet summarizesof EnergyEnergy Tracking

  11. National Clean Energy Business Plan Competition: Five Regional Winners Head

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels Data CenterEnergyGlossary ofHomeJC3Minh Le AboutNO FEAR Act Notice NOto

  12. MHK Projects/Kendall Head Tidal Energy | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to: navigation, searchOf KilaueaInformationCygnet < MHKSound,Ironton LightKempe BendOcean

  13. Indian Head Park, Illinois: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetecGtel JumpCounty,Jump7 Varnish cacheTransport and BuildingCreek,

  14. Department of Energy Contractor Diana Lewis Heading to National Small

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197 ThisFinalResearch andandDepartment of EnergyBusiness

  15. MEMORANDUM FOR HEADS OF CONTRACTING ACTIVITY AND PROCUREMENT DIRECTORS

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment ofLetterEconomyDr. Ernest Moniz, Secretary26, 2013

  16. MEMORANDUM FOR HEADS OF DEPARTMENTAL ELEMENTS FROM: IN GRID^,,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment ofLetterEconomyDr. Ernest Moniz, Secretary26, 2013,2011 MEMORANDUM

  17. MEMORANDUM FOR HEADS OF DEPARTMENTAL ELEMENTS OTHER THAN THE

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment ofLetterEconomyDr. Ernest Moniz, Secretary26, 2013,2011 MEMORANDUM,

  18. Memorandum for Heads of Federal Departments and Agencies: Emergencies and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment3311, 3312), OctoberMay 18-19, 2004MWMemo of IntentDepartment ofNEPA

  19. BLUETEC - Heading for 50 State Diesel | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments fromof EnergyBILIWG: Consistentof Energy andBLUETEC -

  20. Council on Environmental Quality - Memorandum for Heads of Federal

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand JumpConceptual Model, clickInformationNew|Core Analysis AtSystemsInformationCouleeof