Powered by Deep Web Technologies
Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Structural genomics of infectious disease drug targets: the SSGCID...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

2

Key Agency Targets Summary _FY 2012_.doc  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJeffersonJonathan PershingrelocatesKaye D.Ken T.NA>Kevlar andKey5 B

3

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

4

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

5

Synthetic LDL as targeted drug delivery vehicle  

DOE Patents [OSTI]

The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

2012-08-28T23:59:59.000Z

6

A Key Target for Diabetes Drugs | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered‰PNGExperience hands-onASTROPHYSICSHe β-Research andA Hollow-IonHybridA

7

Target Selection for the LBTI Exozodi Key Science Program  

E-Print Network [OSTI]

The Hunt for Observable Signatures of Terrestrial planetary Systems (HOSTS) on the Large Binocular Telescope Interferometer will survey nearby stars for faint emission arising from ~300 K dust (exozodiacal dust), and aims to determine the exozodiacal dust luminosity function. HOSTS results will enable planning for future space telescopes aimed at direct spectroscopy of habitable zone terrestrial planets, as well as greater understanding of the evolution of exozodiacal disks and planetary systems. We lay out here the considerations that lead to the final HOSTS target list. Our target selection strategy maximizes the ability of the survey to constrain the exozodi luminosity function by selecting a combination of stars selected for suitability as targets of future missions and as sensitive exozodi probes. With a survey of approximately 50 stars, we show that HOSTS can enable an understanding of the statistical distribution of warm dust around various types of stars and is robust to the effects of varying levels ...

Weinberger, Alycia J; Kennedy, Grant M; Roberge, Aki; Defrre, Denis; Hinz, Philip M; Millan-Gabet, Rafael; Rieke, George; Bailey, Vanessa P; Danchi, William C; Haniff, Chris; Mennesson, Bertrand; Serabyn, Eugene; Skemer, Andrew J; Stapelfeldt, Karl R; Wyatt, Mark C

2015-01-01T23:59:59.000Z

8

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network [OSTI]

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

9

Computational analysis of biochemical networks for drug target identification and therapeutic intervention design  

E-Print Network [OSTI]

Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear ...

Paudel, Nirmala

2014-01-01T23:59:59.000Z

10

Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery  

E-Print Network [OSTI]

The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

Tan, Mei Chee

11

REVIEWS Drug Discovery Today Volume 12, Numbers 1/2 January 2007 Drug-target identification in Drosophila  

E-Print Network [OSTI]

the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery studies over the years has relied on the ease of growing this organism and the powerful genetic tools such as the insulin, epidermal growth factor, transforming growth factor b, Wnt, Hedgehog, JAK/STAT and Notch pathways

Perrimon, Norbert

12

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassiveSubmittedStatusButler Tina ButlerToday inm"Topo II: An Enzyme Target for

13

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism in Layered NbS2Topo II: An Enzyme Target for Antibacterial and Cancer

14

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism in Layered NbS2Topo II: An Enzyme Target for Antibacterial and

15

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism in Layered NbS2Topo II: An Enzyme Target for Antibacterial andTopo II:

16

The licensing of patents in return for a fee or royalties has a key role in drug discovery.  

E-Print Network [OSTI]

The licensing of patents in return for a fee or royalties has a key role in drug discovery. Now the licensee brings out a new product, it may be unclear whether they need to pay royalty fees to the patentee patents in exchange for royalty payments; however, they disputed whether the licence of two patents

Cai, Long

17

International Experience with Key Program Elements of IndustrialEnergy Efficiency or Greenhouse Gas Emissions Reduction Target-SettingPrograms  

SciTech Connect (OSTI)

Target-setting agreements, also known as voluntary ornegotiated agreements, have been used by a number of governments as amechanism for promoting energy efficiency within the industrial sector. Arecent survey of such target-setting agreement programs identified 23energy efficiency or GHG emissions reduction voluntary agreement programsin 18 countries. International best practice related to target-settingagreement programs calls for establishment of a coordinated set ofpolicies that provide strong economic incentives as well as technical andfinancial support to participating industries. The key program elementsof a target-setting program are the target-setting process,identification of energy-saving technologies and measures usingenergy-energy efficiency guidebooks and benchmarking as well as byconducting energy-efficiency audits, development of an energy-savingsaction plan, development and implementation of energy managementprotocols, development of incentives and supporting policies, monitoringprogress toward targets, and program evaluation. This report firstprovides a description of three key target-setting agreement programs andthen describes international experience with the key program elementsthat comprise such programs using information from the three keytarget-setting programs as well as from other international programsrelated to industrial energy efficiency or GHG emissionsreductions.

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-02-02T23:59:59.000Z

18

Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)  

ScienceCinema (OSTI)

Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

Forte, Trudy

2011-04-28T23:59:59.000Z

19

Key Elements of and Materials Performance Targets for Highly Insulating Window Frames  

SciTech Connect (OSTI)

The thermal performance of windows is important for energy efficient buildings. Windows typically account for about 30-50 percent of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U-factor of their opaque counterparts (wall, roof and floor constructions). In well insulated buildings the U-factor of walls, roofs an floors can be between 0.1-0.2 W/(m2K). The best windows have U-values of about 0.7-1.0. It is therefore obvious that the U-factor of windows needs to be reduced, even though looking at the whole energy balance for windows (i.e. solar gains minus transmission losses) makes the picture more complex.In high performance windows the frame design and material use is of utmost importance, as the frame performance is usually the limiting factor for reducing the total window U-factor further. This paper describes simulation studies analyzing the effects on frame and edge-of-glass U-factors of different surface emissivities as well as frame material and spacer conductivities. The goal of this work is to define materials research targets for window frame components that will result in better frame thermal performance than is exhibited by the best products available on the market today.

Gustavsen, Arild; Grynning, Steinar; Arasteh, Dariush; Jelle, Bjorn Petter; Goudey, Howdy

2011-03-28T23:59:59.000Z

20

Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells  

E-Print Network [OSTI]

was found to induce marked tumor regression. The discovery of nitrogen mustard as a novel anticancer drug resulted in a great deal of optimism that cancer could finally be cured. A burst of research activity to develop new anticancer drugs therefore... of activity against normal cells. Indeed, many novel anticancer agents continue to be identified, but few find clinical utility due to unacceptable toxicity [17], a clear indicator that there is a need for a screening approach that can identify potent drugs...

Ndolo, Rosemary A.

2012-08-31T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics  

SciTech Connect (OSTI)

Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: A novel computational framework was developed for mechanistic study of SADRs. Off-targets of drugs were identified in large scale and in a high-throughput manner. SADRs like cardiac disorders were systematically explored in molecular networks. A number of ADR-associated proteins were identified.

Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

2014-01-01T23:59:59.000Z

22

Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion  

SciTech Connect (OSTI)

Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 {mu}g/ml S-ketamine over 120 min under isoflurane anesthesia was performed in Shetland ponies. A quantitative electromyographic assessment of the NWR was done before, during and after the TCI. Plasma levels of R-/S-ketamine and R-/S-norketamine were determined by enantioselective capillary electrophoresis. These data and two additional data sets from bolus studies were used to build a PBPk model for ketamine in ponies. The peak-to-peak amplitude and the duration of the NWR decreased significantly during TCI and returned slowly toward baseline values after the end of TCI. The PBPk model provides reliable prediction of plasma and tissue levels of R- and S-ketamine and R- and S-norketamine. Furthermore, biotransformation of ketamine takes place in the liver and in the lung via first-pass metabolism. Plasma concentrations of S-norketamine were higher compared to R-norketamine during TCI at all time points. Analysis of the data suggested identical biotransformation rates from the parent compounds to the principle metabolites (R- and S-norketamine) but different downstream metabolism to further metabolites. The PBPk model can provide predictions of R- and S-ketamine and norketamine concentrations in other clinical settings (e.g. horses)

Knobloch, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland); Portier, C.J. [Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 (United States); Levionnois, O.L. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Theurillat, R. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Thormann, W. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Spadavecchia, C. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Mevissen, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland)]. E-mail: meike.mevissen@vpi.unibe.ch

2006-11-01T23:59:59.000Z

23

E-Print Network 3.0 - antibiotic drug targets Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

aureus1 Summary: or lack the target of the antibiotic. b | Multidrug resistance efflux pumps. These pumps secrete... modify the target protein, for example by disabling the...

24

E-Print Network 3.0 - anticancer drug targets Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Toronto Collection: Biology and Medicine 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

25

Abstract--Wave energy will have a key role in meeting re-newable energy targets en route to a low carbon economy. How-  

E-Print Network [OSTI]

1 Abstract--Wave energy will have a key role in meeting re- newable energy targets en route will impact on wave energy conversion. Where the resource is restricted there may be reductions in energy the sensitivity of wave energy production and econom- ics to changes in climate. Index Terms--Wave energy

Harrison, Gareth

26

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

27

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

Affairs (DEFRA), 2005. UK Emissions Trading Scheme. http://targets through the UK Emissions Trading Scheme. 6 Table 1is to be adjusted for emissions trading. The reports must be

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

28

Drug Target Optimization in Chronic Myeloid Leukemia Using Innovative Computational Platform  

E-Print Network [OSTI]

L, proliferation was reduced in the CP CML state and apoptosis induced, consistent with results found by Seo et al29. Proliferation was slowed in the BC CML state from 2 to 1 and apoptosis increased to 1, but otherwise remained the same as the baseline BC CML... | 5 : 8190 | DOI: 10.1038/srep08190 8 28. Zhao, X. M. et al. Prediction of drug combinations by integrating molecular and pharmacological data. PLoS computational biology 7, e1002323, doi:10.1371/ journal.pcbi.1002323 (2011). 29. Seo, J. H. et al. A...

Chuang, Ryan; Hall, Benjamin A.; Benque, David; Cook, Byron; Ishtiaq, Samin; Piterman, Nir; Taylor, Alex; Vardi, Moshe; Koschmieder, Steffen; Gottgens, Berthold; Fisher, Jasmin

2015-02-03T23:59:59.000Z

29

Current Drug Targets, 2006, 7, 000-000 1 1389-4501/06 $50.00+.00 2006 Bentham Science Publishers Ltd.  

E-Print Network [OSTI]

and bring about a prolonged effect. By its binding to plasmatic proteins, resveratrol also exhibits a prolonged effect. Interestingly, low doses of res- veratrol can sensitize to low doses of cytotoxic drugs or chemotherapeutic strategies and is believed to be a novel weapon for new therapeutic strategies. Key Words

Paris-Sud XI, Universit de

30

Crucial stages of protein folding through a solvable model: Predicting target sites  

E-Print Network [OSTI]

Crucial stages of protein folding through a solvable model: Predicting target sites for enzyme. Keywords: Protein-folding modeling; prediction of key folding sites; HIV-1 protease; drug resistance One

Cecconi, Fabio

31

Oral Drug Absorption  

E-Print Network [OSTI]

properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

Yamashita, Shinji

2006-10-26T23:59:59.000Z

32

Smart drug discovery leveraging innovative technologies and predictive knowledge  

E-Print Network [OSTI]

the risk of failure. Owing to the integration of key in silico and experimental tools. A positive aspect of this paradigm shift includes faster,strategic decision making with respect to drug targets from the human genome pro- vides opportunities for detailed analysis of structure and function

Cai, Long

33

Mechanical loading impacts intramuscular drug transport : impact on local drug delivery  

E-Print Network [OSTI]

Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue ...

Wu, Peter I-Kung

2008-01-01T23:59:59.000Z

34

Mechanism of Binding and Internalization of ICAM-1-derived Cyclic Peptides by LFA-1 on the Surface of T-cells: A Potential Method for Targeted Drug Delivery  

E-Print Network [OSTI]

Purpose Peptides derived from the Domain 1 of the adhesion molecule ICAM-1(1-21) are being developed as targeting ligands for LFA-1 receptors expressed on activated T-cells. This work aims to elucidate the binding and ...

Anderson, Meagan E.; Siahaan, Teruna J.

2003-10-01T23:59:59.000Z

35

Assess the key physics that underpins high-hydro coupling-efficiency in NDCX-II experiments and high-gain heavy ion direct drive target designs using proven hydro codes like HYDRA  

E-Print Network [OSTI]

physics that underpins high-hydro coupling-efficiency in N Dtarget designs using proven hydro codes like H Y D R A . byF E targets, we have studied hydro and implosion efficiency

Barnard, J. J.

2010-01-01T23:59:59.000Z

36

Controlling drug delivery across the placenta: A commentary  

E-Print Network [OSTI]

A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

Audus, Kenneth L.

1999-01-01T23:59:59.000Z

37

Public Key Cryptography and Key Management  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The use and management of certificate-based public key cryptography for the Department of Energy (DOE) requires the establishment of a public key infrastructure (PKI). This chapter defines the policy related to roles, requirements, and responsibilities for establishing and maintaining a DOE PKI and the documentation necessary to ensure that all certificates are managed in a manner that maintains the overall trust required to support a viable PKI. Canceled by DOE N 251.112.

2000-02-15T23:59:59.000Z

38

Key Milestones/Outlook  

Broader source: Energy.gov [DOE]

Key Milestones/Outlook per the Department of Energy 2015 Congressional Budget Request, Environmental Management, March 2014

39

The x-ray crystal structure analysis of the complex formed by trypsin with the thrombin inhibitor 4-chloro-3-ethoxy-7-guanidinoisocoumarin: implications for mechanism and drug design  

E-Print Network [OSTI]

been subjected to extensive study as targets of drug and inhibitor design for a variety of reasons. Chief among them is their ubiquitous presence and involvement in key fh j l ~ f tyl d f t ~h' h ' t physiological processes, ranging from digestion... specific proteases and inhibitors could then serve as a paradigm for molecular modelling, and for drug design and synthesis in other lesser known enzyme-substrate/inhibitor systems. Two main classes of inhibitors have been studied as potential...

Chow, Margaret Mei-Shin

1990-01-01T23:59:59.000Z

40

Quantum dense key distribution  

SciTech Connect (OSTI)

This paper proposes a protocol for quantum dense key distribution. This protocol embeds the benefits of a quantum dense coding and a quantum key distribution and is able to generate shared secret keys four times more efficiently than the Bennet-Brassard 1984 protocol. We hereinafter prove the security of this scheme against individual eavesdropping attacks, and we present preliminary experimental results, showing its feasibility.

Degiovanni, I.P.; Ruo Berchera, I.; Castelletto, S.; Rastello, M.L.; Bovino, F.A.; Colla, A.M.; Castagnoli, G. [Istituto Elettrotecnico Nazionale G. Ferraris, Strada delle Cacce 91, 10135 Torino (Italy); ELSAG SpA, Via Puccini 2, 16154, Genova (Italy)

2004-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Targeting of drugs and nanoparticles to tumors  

E-Print Network [OSTI]

The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as ...

Ruoslahti, Erkki

42

Key Events Timeline  

Broader source: Energy.gov [DOE]

This document lists key events beginning with the April 20 fire on the Deepwater Horizon through July 28th. Updated July 28, 2010.

43

Optical key system  

DOE Patents [OSTI]

An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

Hagans, Karla G. (Livermore, CA); Clough, Robert E. (Danville, CA)

2000-01-01T23:59:59.000Z

44

Assessing the impact of tumor evolution on oncology drug development and commercialization  

E-Print Network [OSTI]

This thesis investigates the commercial viability of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs ...

Sterk, Joseph P. (Sterk, Joseph Phillip)

2011-01-01T23:59:59.000Z

45

Key Elements of and Materials Performance Targets for Highly  

E-Print Network [OSTI]

and Technology, Hgskoleringen 7A, NO-7491 Trondheim, Norway Abstract The thermal performance of windows of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U

46

Cryptographic Key Management System  

SciTech Connect (OSTI)

This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene#12;ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

No, author

2014-02-21T23:59:59.000Z

47

ARM - Key Science Questions  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc Documentation RUC : XDCResearch Related Information Collaborations Meetings ofgovScienceKey

48

NETL: Key Staff  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas Conchas recovery challengeMultiscaleLogos NERSCJeffreyKey Actions forEnergy Systems

49

Key recycling in authentication  

E-Print Network [OSTI]

In their seminal work on authentication, Wegman and Carter propose that to authenticate multiple messages, it is sufficient to reuse the same hash function as long as each tag is encrypted with a one-time pad. They argue that because the one-time pad is perfectly hiding, the hash function used remains completely unknown to the adversary. Since their proof is not composable, we revisit it using a composable security framework. It turns out that the above argument is insufficient: if the adversary learns whether a corrupted message was accepted or rejected, information about the hash function is leaked, and after a bounded finite amount of rounds it is completely known. We show however that this leak is very small: Wegman and Carter's protocol is still $\\epsilon$-secure, if $\\epsilon$-almost strongly universal$_2$ hash functions are used. This implies that the secret key corresponding to the choice of hash function can be reused in the next round of authentication without any additional error than this $\\epsilon$. We also show that if the players have a mild form of synchronization, namely that the receiver knows when a message should be received, the key can be recycled for any arbitrary task, not only new rounds of authentication.

Christopher Portmann

2014-09-29T23:59:59.000Z

50

Key-shift transmission  

SciTech Connect (OSTI)

A key-shift transmission is described, characterized by the speed-change shaft being divided into a pair of trough-shaped shaft halves each having an arched inner surface which defines a part of a cylindrical bore extending axially through the speed-change shaft thereby the shaft being formed into a hollow shaft, and by each of the shaft halves including a pair of flattened end surfaces which extend axially of each shaft half at both sides of the inner surface, one of the end surfaces having thereon an axially elongated projection and the other of the end surfaces having herein an axially elongated recess of a depth smaller than the height of the projection. The pair of shaft halves are engaged to each other co-rotatably by fitting the projections of the respective shaft halves into the recesses of the respective shaft halves so as to form in an outer surface of the speed-change shaft a pair of elongated axial grooves which are located radially outwardly of the elongated projections of the respective shaft halves and between the flattened end surfaces of the respective shaft halves. A pair of the shift keys are disposed within the pair of elongated axial grooves.

Nemoto, S.

1989-03-07T23:59:59.000Z

51

TARGET STATION INFRASTRUCTURE THE CNGS EXPERIENCE  

E-Print Network [OSTI]

of Aluminum Water cooled Current: 150kA (horn) ­ 180 kA (reflector) Pulse duration 7ms #12;Key elements Remote handling Remote station for radiation survey in the target chamber #12;CNGS Target Area I per cooling circuit 2007 run radiation effects on ventilation system electronics broken flexible stripline

McDonald, Kirk

52

Synthesis and Characterization of a Magnetically Responsive Polymeric Drug Delivery System  

E-Print Network [OSTI]

A magnetic target drug delivery system consisting of biodegradable polymeric microspheres (poly D, L-lactic acid) loaded with magnetite nanoparticles (10-100 nm) and anticancer drug (paclitaxel) was studied. The magnetite ...

Yu, Shi

53

Accelerator target  

DOE Patents [OSTI]

A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

1999-06-29T23:59:59.000Z

54

Accelerator target  

DOE Patents [OSTI]

A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

Schlyer, David J. (Bellport, NY); Ferrieri, Richard A. (Patchogue, NY); Koehler, Conrad (Miller Place, NY)

1999-01-01T23:59:59.000Z

55

Drug Retention Times  

SciTech Connect (OSTI)

The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

Center for Human Reliability Studies

2007-05-01T23:59:59.000Z

56

Drug Retention Times  

SciTech Connect (OSTI)

The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

Center for Human Reliability Studies

2007-05-01T23:59:59.000Z

57

Protein encapsulated magnetic carriers for micro/nanoscale drug delivery systems.  

SciTech Connect (OSTI)

Novel methods for drug delivery may be based on nanotechnology using non-invasive magnetic guidance of drug loaded magnetic carriers to the targeted site and thereafter released by external ultrasound energy. The key building block of this system is to successfully synthesize biodegradable, magnetic drug carriers. Magnetic carriers using poly(D,L-lactide-co-glycolide) (PLGA) or poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) as matrix materials were loaded with bovine serum albumin (BSA) by a double-emulsion technique. BSA-loaded magnetic microspheres were characterized for size, morphology, surface charge, and magnetization. The BSA encapsulation efficiency was determined by recovering albumin from the microspheres using dimethyl sulfoxide and 0.05N NaOH/0.5% SDS then quantifying with the Micro-BCA protein assay. BSA release profiles were also determined by the Micro-BCA protein assay. The microspheres had drug encapsulation efficiencies up to 90% depending on synthesis parameters. Particles were spherical with a smooth or porous surface having a size range less than 5 {mu}m. The surface charge (expressed as zeta potential) was near neutral, optimal for prolonged intravascular survival. The magnetization of these BSA loaded magnetic carriers was 2 to 6 emu/g, depending on the specific magnetic materials used during synthesis.

Xie, Y.; Kaminski, M. D.; Mertz, C. J.; Finck, M. R.; Guy, S. G.; Chen, H.; Rosengart, A. J.; Chemical Engineering; Univ. of Chicago, Pritzker School of Medicine

2005-01-01T23:59:59.000Z

58

Quantum key distribution with key extracted from basis information  

E-Print Network [OSTI]

In conventional quantum key distribution protocols, the secure key is normally extracted from the measurement outcomes of the system. Here, a different approach is proposed, where the secure key is extracted from the measurement bases, rather than outcomes. Compared to the original Bennett-Brassard-1984 protocol, the proposed protocol involves no hardware change but modifications in data postprocessing. We show that this protocol is more robust against detector efficiency attacks and photon-number-splitting attacks when practical detectors and photon sources are used.

Xiongfeng Ma

2014-10-20T23:59:59.000Z

59

Tomography increases key rates of quantum-key-distribution protocols  

E-Print Network [OSTI]

We construct a practically implementable classical processing for the BB84 protocol and the six-state protocol that fully utilizes the accurate channel estimation method, which is also known as the quantum tomography. Our proposed processing yields at least as high key rate as the standard processing by Shor and Preskill. We show two examples of quantum channels over which the key rate of our proposed processing is strictly higher than the standard processing. In the second example, the BB84 protocol with our proposed processing yields a positive key rate even though the so-called error rate is higher than the 25% limit.

Shun Watanabe; Ryutaroh Matsumoto; Tomohiko Uyematsu

2008-07-22T23:59:59.000Z

60

E-Print Network 3.0 - anticancer drug cisplatin Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

on mitochondrial oxygen consumption Abdul-Kader Souida... June 2003 Abstract The evolving role of mitochondria as a target for many anticancer drugs (e... DNA platination by...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Drug smuggling safety tests [July 1, 2006  

E-Print Network [OSTI]

enough to be utilized as drug carriers. Suslick adds that the three tests on mammalian cells they carried evidence of nano safety Login | Register Search: Site X-Ray Page 1 of 2X-Ray - Your Guide to All the Key X About Us | Contact Us | Privacy Policy | Terms & Conditions | Advertising | RSS Interested

Suslick, Kenneth S.

62

The LOFAR Transients Key Project  

E-Print Network [OSTI]

LOFAR, the Low Frequency Array, is a new radio telescope under construction in the Netherlands, designed to operate between 30 and 240 MHz. The Transients Key Project is one of the four Key Science Projects which comprise the core LOFAR science case. The remit of the Transients Key Project is to study variable and transient radio sources detected by LOFAR, on timescales from milliseconds to years. This will be achieved via both regular snapshot monitoring of historical and newly-discovered radio variables and, most radically, the development of a `Radio Sky Monitor' which will survey a large fraction of the northern sky on a daily basis.

Rob Fender; Robert Braun; Ben Stappers; Ralph Wijers; Michael Wise; Thijs Coenen; Heino Falcke; Jean-Mathias Griessmeier; Michiel van Haarlem; Peter Jonker; Casey Law; Sera Markoff; Joseph Masters; James Miller-Jones; Rachel Osten; Bart Scheers; Hanno Spreeuw; John Swinbank; Corina Vogt; Rudy Wijnands; Philippe Zarka

2006-11-09T23:59:59.000Z

63

Identifying novel drug indications through automated reasoning Authors and Affiliations  

E-Print Network [OSTI]

of these drugs have potential anti-cancer activities based on information on their targets and molecular discovery, text mining, automated reasoning Abstract Background With the large amount of pharmacological interaction types alone. A total of 507 drugs were found to have the potential to be used for cancer

Baral, Chitta

64

WP1: Targeted and informative forecast system design  

E-Print Network [OSTI]

WP1: Targeted and informative forecast system design Emma Suckling, Leonard A. Smith and David Stainforth EQUIP Meeting ­ August 2011 Edinburgh #12;Targeted and informative forecast system design Develop models to support decision making (1.4) #12;Targeted and informative forecast system design KEY QUESTIONS

Stevenson, Paul

65

Key Issues | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensionalthe10 DOEWashington, DC 20585on253.16582104)Key Issues Key Issues

66

Key Activities | Department of Energy  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel2007 | Department7JanuaryWASTE-TO-ENERGY:About » KeyKey

67

Key Activities | Department of Energy  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel2007 | Department7JanuaryWASTE-TO-ENERGY:About » KeyKeyAbout the

68

Monroe County Extension Services Key West Office  

E-Print Network [OSTI]

Energy Services: 305-295-1010 Florida Keys Electric Co-op: 305-852-2431 Monroe County Roads & Bridges-292-4501 http://monroe.ifas.ufl.edu Key Largo Office: 102050 Overseas Highway, Room 244 City and County Tree Lower Keys: 305-797-4929 Upper Keys: 305-852-7161 Contact local tree services throughout the Keys

Jawitz, James W.

69

Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive  

E-Print Network [OSTI]

Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems describe the development of multifunctional polymeric micelles with cancer-targeting capability via rv 3 and rv 3-specific cytotoxic response of these multifunctional polymeric micelles. Over the past several

Gao, Jinming

70

Key-Insulated Symmetric Key Cryptography and Mitigating Attacks against Cryptographic Cloud Software  

E-Print Network [OSTI]

Key-Insulated Symmetric Key Cryptography and Mitigating Attacks against Cryptographic Cloud- sociated cryptographic keys in their entirety. In this paper, we investigate key-insulated symmetric key. To illustrate the feasibility of key-insulated symmetric key cryptography, we also report a proof

Dodis, Yevgeniy

71

DOI: 10.1002/cmdc.200800122 HER-2-Targeted NanoparticleAffibody Bioconjugates for Cancer Therapy  

E-Print Network [OSTI]

shown that this class of molecule can se- lectively bind to HER-2-overexpressing cell lines (SKBR-3 drug toxicity, and maintaining a relatively high concentration of drug at the site of interest.[1 drugs to diseased cells. The first examples of targeted NPs were reported in 1980, and despite nearly

Zhang, Liangfang

72

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

8 22 | Next | Last Back to Index NIF Target Chamber The interior of the NIF target chamber. The service module carrying technicians can be seen on the left. The target...

73

Brain Receptor Structures Key to Future Therapeutics  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Brain Receptor Structures Key to Future Therapeutics Brain Receptor Structures Key to Future Therapeutics Print Wednesday, 28 January 2015 00:00 With an aging population in...

74

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

6 22 | Next | Last Back to Index NIF Target Chamber A service system lift allows technicians to access the target chamber interior for inspection and maintenance. Photo Number:...

75

Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System  

E-Print Network [OSTI]

+/- 10 nm were fabricated, characterized and then encapsulated in synthetic / biomacromolecule shell chitosan, dextran-sulfate using a layer by layer (LbL) self-assembly technique. Surface modifications were performed by covalently conjugating with poly...

Yu, Xiao

2012-07-16T23:59:59.000Z

76

Pharmacokinetics, or "How a drug reaches its target"  

E-Print Network [OSTI]

15 20 25 30 35 40 45 Time (days) Concentration(mg·L-1) InL Michaelis-Menten(L) Cld CP, VcCt, Vt koff ke(RL) InL L = Ligand R = receptor RL = Receptor-Ligand complex ke(L) Parameter fit for data set 2 The dynamics is given by the system of nonlinear differential equations: dL dt = InL - konL · R + koff

Gugat, Martin

77

Gastric H,K-ATPase as a drug target  

E-Print Network [OSTI]

Review article: Helicobacter pylori and gastro- oesophagealWL: The treatment of Helicobacter pylori infection in thewith infection by Helicobacter pylori and the realization

Shin, Jai M; Sachs, G

2006-01-01T23:59:59.000Z

78

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism in Layered NbS2

79

Structural genomics of infectious disease drug targets: the SSGCID. | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systemsBiSiteNeutronStrategicOur Mission Oura metalloproteinof infectious

80

Targeted Drug Delivery To Leukocytes with ICAM-1 Derived Peptides  

E-Print Network [OSTI]

cells by receptor mediated endocytosis and passive diffusion, respectively. High hydrophobicity of DOX-cIBR was proposed to be responsible for its energy-independent entry (chapter 2). To check the effect of hydrophobicity on internalization, two...

Majumdar, Sumit

2008-07-15T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Gastric H,K-ATPase as a drug target  

E-Print Network [OSTI]

cations. J Biol Chem Fukushima Y, Nakao M: Changes inChem 1980;255(16):7813-9. Fukushima Y, Post RL: Binding of

Shin, Jai M; Sachs, G

2006-01-01T23:59:59.000Z

82

Key Activities | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGYWomen OwnedofDepartment ofJared Temanson - Project LeaderDepartment's DirectivesKey

83

Key Activities | Department of Energy  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel2007 | Department7JanuaryWASTE-TO-ENERGY:About » Key

84

Public/private key certification authority and key distribution. Draft  

SciTech Connect (OSTI)

Traditional encryption, which protects messages from prying eyes, has been used for many decades. The present concepts of encryption are built from that heritage. Utilization of modern software-based encryption techniques implies much more than simply converting files to an unreadable form. Ubiquitous use of computers and advances in encryption technology coupled with the use of wide-area networking completely changed the reasons for utilizing encryption technology. The technology demands a new and extensive infrastructure to support these functions. Full understanding of these functions, their utility and value, and the need for an infrastructure, takes extensive exposure to the new paradigm. This paper addresses issues surrounding the establishment and operation of a key management system (i.e., certification authority) that is essential to the successful implementation and wide-spread use of encryption.

Long, J.P.; Christensen, M.J.; Sturtevant, A.P.; Johnston, W.E.

1995-09-25T23:59:59.000Z

85

First SNS Target Replacement  

E-Print Network [OSTI]

First SNS Target Replacement Experience M. Dayton, M. Rennich, Van Graves, J. DeVore Presented by T.S. Department of Energy AHIP Workshop Oct. 2009 Overview · Initial Target Replacement · Target Maintenance-Battelle for the U.S. Department of Energy AHIP Workshop Oct. 2009 First SNS Target Replacement · Replacement

McDonald, Kirk

86

MECO Production Target Developments  

E-Print Network [OSTI]

be reoptimized Tungsten target Simulations of design parameters with GEANT3 indicate that both production targetMECO Production Target Developments James L. Popp University of California, Irvine NuFact'03 Columbia, June, 2003 #12;June, 2003J.L.Popp, UCI MECO Production Target 2 MECO Collaboration Institute

McDonald, Kirk

87

Optically generated ultrasound for enhanced drug delivery  

DOE Patents [OSTI]

High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

2002-01-01T23:59:59.000Z

88

COLLEGE AVE CAMPUS (CAC) KEY PICK UP  

E-Print Network [OSTI]

COLLEGE AVE CAMPUS (CAC) KEY PICK UP NOTE TO ALL STUDENTS: ONLY YOU CAN PICK UP YOUR KEY. You in and key pick up. If you are unable to pick up your key by 5:00 p.m. on September 1st , please make prior in Clothier Hall on CAC. Keys not picked up during the above-noted hours can be picked up at the Housing

89

Polarized internal target apparatus  

DOE Patents [OSTI]

A polarized internal target apparatus with a polarized gas target of improved polarization and density achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms.

Holt, Roy J. (Downers Grove, IL)

1986-01-01T23:59:59.000Z

90

Polarized internal target apparatus  

DOE Patents [OSTI]

A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

Holt, R.J.

1984-10-10T23:59:59.000Z

91

Magnetically attached sputter targets  

DOE Patents [OSTI]

An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

Makowiecki, D.M.; McKernan, M.A.

1994-02-15T23:59:59.000Z

92

Answering Key Fuel Cycle Questions  

SciTech Connect (OSTI)

The Advanced Fuel Cycle Initiative (AFCI) program has both outcome and process goals because it must address both waste already accumulating as well as completing the fuel cycle in connection with advanced nuclear power plant concepts. The outcome objectives are waste geological repository capacity and cost, energy security and sustainability, proliferation resistance, fuel cycle economics, and safety. The process objectives are readiness to proceed and adaptability and robustness in the face of uncertainties. A classic decision-making approach to such a multi-attribute problem would be to weight individual quantified criteria and calculate an overall figure of merit. This is inappropriate for several reasons. First, the goals are not independent. Second, the importance of different goals varies among stakeholders. Third, the importance of different goals is likely to vary with time, especially the energy future. Fourth, some key considerations are not easily or meaningfully quantifiable at present. Instead, at this point, we have developed 16 questions the AFCI program should answer and suggest an approach of determining for each whether relevant options improve meeting each of the program goals. We find that it is not always clear which option is best for a specific question and specific goal; this helps identify key issues for future work. In general, we suggest attempting to create as many win-win decisions (options that are attractive or neutral to most goals) as possible. Thus, to help clarify why the program is exploring the options it is, and to set the stage for future narrowing of options, we have developed 16 questions, as follows: What are the AFCI program goals? Which potential waste disposition approaches do we plan for? What are the major separations, transmutation, and fuel options? How do we address proliferation resistance? Which potential energy futures do we plan for? What potential external triggers do we plan for? Should we separate uranium? If we separate uranium, should we recycle it, store it or dispose of it? Is it practical to plan to fabricate and handle hot fuel? Which transuranic elements (TRU) should be separated and transmuted? Of those TRU separated, which should be transmuted together? Should we separate and/or transmute Cs and Sr isotopes that dominate near-term repository heating? Should we separate and/or transmute very long-lived Tc and I isotopes? Which separation technology? What mix of transmutation technologies? What fuel technology best supports the above decisions?

Steven J. Piet; Brent W. Dixon; J. Stephen Herring; David E. Shropshire; Mary Lou Dunzik-Gougar

2003-10-01T23:59:59.000Z

93

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

8 22 | Next | Last Back to Index NIF Target A NIF target contains a polished capsule about two millimeters in diameter, filled with cryogenic (super-cooled) hydrogen fuel. Photo...

94

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

5 22 | Next | Last Back to Index NIF Target Chamber This view from the bottom of the chamber shows the target positioner being inserted. Pulses from NIF's high-powered lasers...

95

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

9 22 | Next | Last Back to Index NIF Hohlraum A metallic case called a hohlraum holds the fuel capsule for NIF experiments. Target handling systems precisely position the target...

96

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3 22 | Next | Last Back to Index NIF Target Chamber Temperatures of 100 million degrees and pressures extreme enough to compress the target to densities up to 100 times the...

97

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to Index Target Chamber Viewing Window A new viewing window recently installed on the NIF Target Chamber will allow members of the NIF team and visitors to see inside the...

98

High Power Cryogenic Targets  

SciTech Connect (OSTI)

The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

Gregory Smith

2011-08-01T23:59:59.000Z

99

Lightweight Key Establishment for Distributed Networking Environments  

E-Print Network [OSTI]

/ COSIC Seminar 2007 Keith Martin #12;Lightweight Key Establishment/Introduction The plan 1. Wireless sensor networks 2. A key establishment framework 3. Key establishment for grids COSIC Seminar 2007 Keith Establishment/Wireless sensor networks The "classical" scenario COSIC Seminar 2007 Keith Martin #12;Lightweight

Martin, Keith

100

Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens  

SciTech Connect (OSTI)

Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals, including AIDS patients and transplant recipients. Few antifungals can treat C. neoformans infections, and drug resistance is increasing. Protein farnesyltransferase (FTase) catalyzes post-translational lipidation of key signal transduction proteins and is essential in C. neoformans. We present a multidisciplinary study validating C. neoformans FTase (CnFTase) as a drug target, showing that several anticancer FTase inhibitors with disparate scaffolds can inhibit C. neoformans and suggesting structure-based strategies for further optimization of these leads. Structural studies are an essential element for species-specific inhibitor development strategies by revealing similarities and differences between pathogen and host orthologs that can be exploited. We, therefore, present eight crystal structures of CnFTase that define the enzymatic reaction cycle, basis of ligand selection, and structurally divergent regions of the active site. Crystal structures of clinically important anticancer FTase inhibitors in complex with CnFTase reveal opportunities for optimization of selectivity for the fungal enzyme by modifying functional groups that interact with structurally diverse regions. A substrate-induced conformational change in CnFTase is observed as part of the reaction cycle, a feature that is mechanistically distinct from human FTase. Our combined structural and functional studies provide a framework for developing FTase inhibitors to treat invasive fungal infections.

Hast, Michael A.; Nichols, Connie B.; Armstrong, Stephanie M.; Kelly, Shannon M.; Hellinga, Homme W.; Alspaugh, J. Andrew; Beese, Lorena S. (Duke)

2012-09-17T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

TARGET SPECIES Table 1. Terrestrial target species.  

E-Print Network [OSTI]

that have only one or a very few number of key ecological functions. Functional specialist species could = Critical functional link species, species that are the only ones that perform a specific ecological Merganser Boreal Toad Wolverine FS Horned Grebe Long-toed Salamander CFLS BIRDS House Finch CFLS Northern

102

Targeting Illegal Immigration: Local Ordinate Action  

E-Print Network [OSTI]

is adapted, but distinct from, a report on the topic prepared for the U.S. Congressional Research Service. Local Ordinances Targeting Illegal Immigration 1 Executive Summary It has been traditionally the federal government?s responsibility...,000 municipalities and 3,000 counties in the United States, only 21 localities have passed legislation addressing unauthorized immigration in the key areas thought to influence illegal immigration?housing and employment. These ordinances were all passed between...

Gunn, Emily; Moffitt, Jessica; Montemayor, Victoria; Riedel, Sarah; Smith, Bart; Weizel, Daniel

2008-01-01T23:59:59.000Z

103

The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier  

E-Print Network [OSTI]

It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is ...

Wang, Jing

2008-01-01T23:59:59.000Z

104

A systems approach to uncovering the adaptive response of cancer to targeted therapies  

E-Print Network [OSTI]

Tyrosine kinase inhibitors have significant promise in the fight to develop agents that can target cancer in a tumor-specific manner. A number of drugs have been and are currently in development to inhibit specific kinases ...

Randall, Adrian Joseph

2012-01-01T23:59:59.000Z

105

Non-traditional platinum compounds for improved cellular accumulation and tumor targeting  

E-Print Network [OSTI]

Chapter 1. Introduction to Non-Traditional Platinum Compounds for Improved Uptake, Oral Bioavailability, and Tumor Targeting The path to more potent platinum anticancer drugs with fewer side effects lies in the exploration ...

Lovejoy, Katherine Summer, 1981-

2009-01-01T23:59:59.000Z

106

Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners  

E-Print Network [OSTI]

Background Protein covalent binding by reactive metabolites of drugs, chemicals and natural products can lead to acute cytotoxicity. Recent rapid progress in reactive metabolite target protein identification has shown ...

Hanzlik, Robert P.; Fang, Jianwen; Koen, Yakov M.

2009-06-12T23:59:59.000Z

107

A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy  

E-Print Network [OSTI]

The use of nanotechnology to engineer drug delivery vehicles comprised of controlled release polymers with targeting molecules has the potential to revolutionize cancer therapy, among other diseases. Although a myriad of ...

Valencia, Pedro M. (Pedro Miguel)

2013-01-01T23:59:59.000Z

108

Target Cost Management Strategy  

E-Print Network [OSTI]

Target cost management (TCM) is an innovation of Japanese management accounting system and by common sense has been considered with great interest by practitioners. Nowadays, TCM related

Okano, Hiroshi

1996-01-01T23:59:59.000Z

109

Brain Receptor Structures Key to Future Therapeutics  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases...

110

Drug Delivery DOI: 10.1002/anie.200802260  

E-Print Network [OSTI]

of a model compound, luciferin, from poly(lactic acid) (PLA) particles (approximately 250­350 nm in size nanoparticle could be engineered to target different cells.[3,6] PLA is an Food and Drug Administration (FDA with supercritical carbon dioxide (sc-CO2). PLA can also serve as a representative material for our process which can

Zare, Richard N.

111

Fixed target electroweak and hard scattering physics  

SciTech Connect (OSTI)

The possibilities for future physics and experiments involving weak and electromagnetic interactions, neutrino oscillations, general hard scattering and experiments involving nuclear targets were explored. The studies were limited to the physics accessible using fixed target experimentation. While some of the avenues explored turn out to be relatively unrewarding in the light of competition elsewhere in the world, there are a number of positive conclusions reached about experimentation in the energy range available to the Main Injector and Tevatron. Some of the experiments would benefit from the increased intensity available from the Tevatron utilizing the Main Injector, while some require this increase. Finally, some of the experiments would use the Main Injector low energy, high intensity extracted beams directly. A program of electroweak and hard scattering experiments at fixed target energies retains the potential for important contributions to physics. The key to major parts of this program would appear to be the existence of the Main Injector. 115 refs, 17 figs.

Brock, R. (Michigan State Univ., East Lansing, MI (USA)); Brown, C.N.; Montgomery, H.E. (Fermi National Accelerator Lab., Batavia, IL (USA)); Corcoran, M.D. (eds.) (Rice Univ., Houston, TX (USA))

1990-02-01T23:59:59.000Z

112

Neutrino Factory Target Vessel  

E-Print Network [OSTI]

by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 Cooling Channel in both walls for draining · Downstream end can be shortened, assuming the window cooling is adequate #12;11 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 Remote Handling

McDonald, Kirk

113

Fractalkine Targeting with a Receptor-Mimicking Peptide-Amphiphile  

E-Print Network [OSTI]

. Kasinskas, Anastasia Mardilovich, and Ashish Garg Department of Chemical Engineering and Materials Science drug delivery systems driven by a strong need in clinical practice. Advances in materials science to the target tissue.2 Liposomes have been investigated extensively and long-circulating liposomes (stealth lipo

Kokkoli, Efie

114

Monroe County Extension Services Key West Office  

E-Print Network [OSTI]

-292-4501 http://monroe.ifas.ufl.edu Key Largo Office: 102050 Overseas Highway, Room 244 City and County Tree Energy Services: 305-295-1010 Florida Keys Electric Co-op: 305-852-2431 Monroe County Roads & Bridges conditions based on USDA zone, water and light requirements, soil conditions, salt and wind tolerance

Florida, University of

115

Key Elements of and Materials Performance Targets for Highly Insulating Window Frames  

E-Print Network [OSTI]

of Thermal Performance of the Exterior Envelopes of Wholethermal transmittance (U-factor) of the building envelope,envelope is far less. The reason for this can be found by comparing the thermal

Gustavsen, Arild

2012-01-01T23:59:59.000Z

116

Introduction The kinase Raf is a key target of the Ras GTPase during both  

E-Print Network [OSTI]

substrates (Sontag et al., 1993; Alessi et al., 1995; Wassarman et al., 1996; Maixner et al., 1998; Ugi et al

Baillie, David

117

Key Elements of and Materials Performance Targets for Highly Insulating Window Frames  

E-Print Network [OSTI]

in light green. 2.5 Window Frame E (PVC) Window frame Eis polyvinyl chloride (PVC). We performed calculations forspacer = 0.25?0.1 W/(mK) ? pvc = 0.9 W/(mK), ? eff. ,spacer

Gustavsen, Arild

2012-01-01T23:59:59.000Z

118

Key Elements of and Materials Performance Targets for Highly Insulating Window Frames  

E-Print Network [OSTI]

finite-element method (FEM) program, THERM (Finlayson et al. , 1998), to solve the conductive heat-transfer

Gustavsen, Arild

2012-01-01T23:59:59.000Z

119

Captured key electrical safety lockout system  

DOE Patents [OSTI]

A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member`s second position corresponds to the preselected position at which the key can be removed from and inserted into the lock. 7 figs.

Darimont, D.E.

1995-10-31T23:59:59.000Z

120

Captured key electrical safety lockout system  

SciTech Connect (OSTI)

A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member's second position corresponds to the preselected position at which the key can be removed from and inserted into the lock.

Darimont, Daniel E. (Aurora, IL)

1995-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Experimental study of high speed polarization-coding quantum key distribution with sifted-key  

E-Print Network [OSTI]

and links 1. C. H. Bennet and G. Brassard, "Quantum cryptography: Public key distribution and coin tossing

122

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 22 | Next | Last Back to Index NIF Hohlraum This artist's rendering shows a NIF target pellet inside a hohlraum capsule with laser beams entering through openings on either...

123

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 22 | Next | Last Back to Index NIF Target Chamber On March 10, 2009, at 3:15 a.m., a 192-beam laser shot delivered 1.1 million joules of ultraviolet light to the center of the...

124

SNS Target Systems Operational  

E-Print Network [OSTI]

a failed gas seal on the shaft and leaking oil seals but has operated well since then · The moderator 7.5 k First target replacement · No observed corrosion · Internal Boroscope examination in progress · ~ 50 mm

McDonald, Kirk

125

Key Implications of the Global Economic Environment  

E-Print Network [OSTI]

Key Implications of the Global Economic Environment For PCT Filings: A Survey of the Issues DMI...............................................................................9 Annex 1: Incentives for Patent Filing: The Analytical Framework...........................11 I-1 Intellectual property, innovation, and economic growth.................................13 2-2 Individual

Lansky, Joshua

126

Extracting secret keys from integrated circuits  

E-Print Network [OSTI]

Modern cryptographic protocols are based on the premise that only authorized participants can obtain secret keys and access to information systems. However, various kinds of tampering methods have been devised to extract ...

Lim, Daihyun, 1976-

2004-01-01T23:59:59.000Z

127

Research Summary Key Ingredients of Collaborative Management  

E-Print Network [OSTI]

, wildlife management and water catchments. This project, developed in discussion with stakeholders, soughtResearch Summary Key Ingredients of Collaborative Management It is widely accepted that collaboration amongst stakeholders can lead to more sustainable land-management. Voluntary collaboration

128

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer  

E-Print Network [OSTI]

Abstract Background The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This can only be achieved if the drug used is against a specific target...

Toyokawa, Gouji; Masuda, Ken; Daigo, Yataro; Cho, Hyun-Soo; Yoshimatsu, Masanori; Takawa, Masashi; Hayami, Shinya; Maejima, Kazuhiro; Chino, Makoto; Field, Helen I; Neal, David E; Tsuchiya, Eiju; Ponder, Bruce A J; Maehara, Yoshihiko; Nakamura, Yusuke; Hamamoto, Ryuji

2011-05-28T23:59:59.000Z

129

MEASUREMENT OF IMPEDANCE CHARACTERISTICS OF COMPUTER KEYBOARD KEYS1  

E-Print Network [OSTI]

of computer keyboard keys are commonly used: rubber-dome and coil-spring keys. As indicated by their names, a rubber-dome key has a rubber dome under the keycap whereas a coil-spring key has a coil spring under of keys. From a user's perspective, the rubber-dome and coil-spring keys feel different. The properties

Nagurka, Mark L.

130

Proceedings of the workshop on polarized targets in storage rings  

SciTech Connect (OSTI)

Polarization phenomena have played an increasingly important part in the study of nuclei and nucleons in recent years. Polarization studies have been hampered by the relatively few and rather fragile polarized targets which are presently available. The concept of polarized gas targets in storage rings opens a much wider range of possibilities than is available in the external target geometry. This novel method will represent a considerable advance in nuclear physics and will continue to receive much attention in plans for future facilities. An internal, polarized-target station is being planned for the cooler ring at the Indiana University Cyclotron Facility. Internal targets are compatible with recent designs of electron accelerators proposed by the Massachusetts Institute of Technology and the Southeastern Universities Research Association. The key to nuclear-science programs based on internal targets pivots on recent developments in polarized atomic beam methods, which include the more recent laser-driven polarized targets. The workshop drew together a unique group of physicists in the fields of high-energy, nuclear and atomic physics. The meeting was organized in a manner that stimulated discussion among the 58 participants and focused on developments in polarized target technology and the underlying atomic physics. An impressive array of future possibilities for polarized targets as well as current developments in polarized target technology were discussed at the workshop. Abstracts of individual items from the workshop were prepared separately for the data base.

Holt, R.J. (ed.)

1984-08-01T23:59:59.000Z

131

Foam encapsulated targets  

DOE Patents [OSTI]

Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

1983-01-01T23:59:59.000Z

132

Target | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia:FAQ < RAPID Jump to:Seadov Pty LtdSteen,Ltd Jump to:Taos County, New Mexico: EnergyTarget GmbH Jump to:Target

133

Mediated Semi-Quantum Key Distribution  

E-Print Network [OSTI]

In this paper, we design a new quantum key distribution protocol, allowing two limited semi-quantum or "classical" users to establish a shared secret key with the help of a fully quantum server. A semi-quantum user can only prepare and measure qubits in the computational basis and so must rely on this quantum server to produce qubits in alternative bases and also to perform alternative measurements. However, we assume that the sever is untrusted and we prove the unconditional security of our protocol even in the worst case: when this quantum server is an all-powerful adversary. We also compute a lower bound of the key rate of our protocol, in the asymptotic scenario, as a function of the observed error rate in the channel allowing us to compute the maximally tolerated error of our protocol. Our results show that a semi-quantum protocol may hold similar security to a fully quantum one.

Walter O. Krawec

2014-11-21T23:59:59.000Z

134

Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster  

E-Print Network [OSTI]

Annotation of regulatory elements and identification of the transcription-related factors (TRFs) targeting these elements are key steps in understanding how cells interpret their genetic blueprint and their environment ...

Slattery, Matthew

135

Public key infrastructure for DOE security research  

SciTech Connect (OSTI)

This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

Aiken, R.; Foster, I.; Johnston, W.E. [and others

1997-06-01T23:59:59.000Z

136

USE OF DRUG ELUTING STENTS AS A FUNCTION OF PREDICTED BENEFIT: CLINICAL AND ECONOMIC IMPLICATIONS OF CURRENT PRACTICE  

E-Print Network [OSTI]

Background: Benefits of drug-eluting stents (DES) in percutaneous coronary intervention (PCI) are greatest in those at the highest risk of target vessel revascularization (TVR). While DES reduce restenosis, they cost more than bare metal stents (BMS...

Amin, Amit P.

2011-12-31T23:59:59.000Z

137

On the Security of Public Key Protocols  

E-Print Network [OSTI]

Recently the use of public key encryption to provide secure network communication has received considerable attention. Such public key systems are usually effective against passive eavesdroppers, who merely tap the lines and try to decipher the message. It has been pointed out, however, that an improperly designed protocol could be vulnerable to an active saboteur, one who may impersonate another user or alter the message being transmitted. Several models are formulated in which the security of protocols can be discussed precisely. Algorithms and characteri-zations that can be used to determine protocol security in these models are given.

Danny Dolev; et al.

1983-01-01T23:59:59.000Z

138

Targeted radionuclide therapy  

SciTech Connect (OSTI)

Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F. [Radiology Division, City of Hope National Medical Center, Duarte, California 91010 (United States); Internal Medicine, University of California Davis Medical Center, 1508 Alhambra Boulevard, Suite 3100, Sacramento, California 95816 (United States); Department of Radiation Oncology, Wallace Tumor Institute WTI No. 117, University of Alabama at Birmingham, Birmingham, Alabama 35294 (United States)

2008-07-15T23:59:59.000Z

139

Future Fixed Target Facilities  

SciTech Connect (OSTI)

We review plans for future fixed target lepton- and hadron-scattering facilities, including the 12 GeV upgraded CEBAF accelerator at Jefferson Lab, neutrino beam facilities at Fermilab, and the antiproton PANDA facility at FAIR. We also briefly review recent theoretical developments which will aid in the interpretation of the data expected from these facilities.

Melnitchouk, Wolodymyr

2009-01-01T23:59:59.000Z

140

Phase-remapping attack in practical quantum-key-distribution systems  

SciTech Connect (OSTI)

Quantum key distribution (QKD) can be used to generate secret keys between two distant parties. Even though QKD has been proven unconditionally secure against eavesdroppers with unlimited computation power, practical implementations of QKD may contain loopholes that may lead to the generated secret keys being compromised. In this paper, we propose a phase-remapping attack targeting two practical bidirectional QKD systems (the 'plug-and-play' system and the Sagnac system). We showed that if the users of the systems are unaware of our attack, the final key shared between them can be compromised in some situations. Specifically, we showed that, in the case of the Bennett-Brassard 1984 (BB84) protocol with ideal single-photon sources, when the quantum bit error rate (QBER) is between 14.6% and 20%, our attack renders the final key insecure, whereas the same range of QBER values has been proved secure if the two users are unaware of our attack; also, we demonstrated three situations with realistic devices where positive key rates are obtained without the consideration of Trojan horse attacks but in fact no key can be distilled. We remark that our attack is feasible with only current technology. Therefore, it is very important to be aware of our attack in order to ensure absolute security. In finding our attack, we minimize the QBER over individual measurements described by a general POVM, which has some similarity with the standard quantum state discrimination problem.

Fung, Chi-Hang Fred; Qi, Bing; Lo, Hoi-Kwong [Center for Quantum Information and Quantum Control, Department of Electrical and Computer Engineering and Department of Physics, University of Toronto, Toronto, Ontario (Canada); Tamaki, Kiyoshi [NTT Basic Research Laboratories, NTT Corporation, 3-1, Morinosato Wakamiya Atsugi-Shi, Kanagawa 243-0198, Japan and CREST, JST Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012 (Japan)

2007-03-15T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

ISAC target vacuum system  

SciTech Connect (OSTI)

The Isotope Separator and Accelerator (ISAC) facility at TRIUMF has been in full operation since 1999. The ISAC east and west targets use proton beam from the cyclotron to produce various radioactive isotopes, which are then ionized and extracted. The ions are then passed through the mass separator and selected ions are transferred to the low energy experiments or injected into a radio frequency quadrupole accelerator. The accompanying radioactive contamination from the production of radioactive ions requires a complex vacuum system. The main target vacuum space consists of two semiseparate (primary and secondary) volumes pumped by turbo-molecular pumps. The primary volume uses four pumps while the secondary volume uses two pumps. Two hermetic rotary vane pumps are used as backing pumps. The nominal vacuum in both volumes is about 1.33x10{sup -4} Pa (1.0x10{sup -6} Torr). The pressure is monitored by two cold cathode and two hot filament ion gauges. The cold cathode gauges are used to interlock the system, which is critical during the bake out of the target and beam production. The exhaust gas from the vacuum pumps can be radioactive. Three gas storage tanks (decay tanks) are used for temporary storage of the radioactive exhaust and its controlled release to the atmosphere. Gas-species insensitive membrane gauges are used for monitoring the pressure in the storage tanks. This article describes the details of the ISAC target vacuum system as well as some procedures related to the handling of the exhaust gas with traces of radioactive contamination produced by the targets.

Yosifov, Dimo; Sekachev, Igor [TRIUMF, Canada's National Laboratory for Particle and Nuclear Physics, Vancouver, British Columbia V6T 2A3 (Canada)

2006-07-15T23:59:59.000Z

142

Solid Target Options S. Childress  

E-Print Network [OSTI]

power is higher than for existing solid target designs - but not by a large factor. · NuMI graphite beam power) · High beam power solid targets frequently use higher z materials for increased yield plusSolid Target Options NuFACT'00 S. Childress Solid Target Options · The choice of a primary beam

McDonald, Kirk

143

Key facts about Argonne National Laboratory  

E-Print Network [OSTI]

Key facts about Argonne National Laboratory Argonne National Laboratory occupies 1,500 wooded acres in southeast DuPage County near Chicago. Mission Argonne's mission is to apply a unique blend of world needs of our nation. Argonne conducts R&D in many areas of basic and applied science and engineering

Kemner, Ken

144

CHEMICAL ABBREVIATION KEY ABBREVIATION CHEMICAL NAME HAZARDS  

E-Print Network [OSTI]

Corrosive - base LiCl Lithium chloride Harmful MeOH Methanol Flammable #12;CHEMICAL ABBREVIATION KEY Irritant destain Methanol,acetic acid,H2O Flammable, Corrosive - acid DI H2O Deionized water DCM FeCl3 Iron(III) chloride Corrosive - acid FeSO4 Iron(II) sulfate Toxic H2O Water HCl Hydrochloric

Pawlowski, Wojtek

145

Roadmap for selected key measurements of LHCb  

E-Print Network [OSTI]

Six of the key physics measurements that will be made by the LHCb experiment, concerning CP asymmetries and rare B decays, are discussed in detail. The "road map" towards the precision measurements is presented, including the use of control channels and other techniques to understand the performance of the detector with the first data from the LHC.

The LHCb Collaboration; B. Adeva; M. Adinolfi; A. Affolder; Z. Ajaltouni; J. Albrecht; F. Alessio; M. Alexander; P. Alvarez Cartelle; A. A. Alves Jr; S. Amato; Y. Amhis; J. Amoraal; J. Anderson; O. Aquines Gutierrez; L. Arrabito; M. Artuso; E. Aslanides; G. Auriemma; S. Bachmann; Y. Bagaturia; D. S. Bailey; V. Balagura; W. Baldini; MdC. Barandela Pazos; R. J. Barlow; S. Barsuk; A. Bates; C. Bauer; Th. Bauer; A. Bay; I. Bediaga; K. Belous; I. Belyaev; M. Benayoun; G. Bencivenni; R. Bernet; M. -O. Bettler; A. Bizzeti; T. Blake; F. Blanc; C. Blanks; J. Blouw; S. Blusk; A. Bobrov; V. Bocci; A. Bondar; N. Bondar; W. Bonivento; S. Borghi; A. Borgia; E. Bos; T. J. V. Bowcock; C. Bozzi; J. Bressieux; S. Brisbane; M. Britsch; N. H. Brook; H. Brown; A. Bchler-Germann; J. Buytaert; J. -P. Cachemiche; S. Cadeddu; J. M. Caicedo Carvajal; O. Callot; M. Calvi; M. Calvo Gomez; A. Camboni; W. Cameron; P. Campana; A. Carbone; G. Carboni; A. Cardini; L. Carson; K. Carvalho Akiba; G. Casse; M. Cattaneo; M. Charles; Ph. Charpentier; A. Chlopik; P. Ciambrone; X. Cid Vidal; P. J. Clark; P. E. L. Clarke; M. Clemencic; H. V. Cliff; J. Closier; C. Coca; V. Coco; J. Cogan; P. Collins; F. Constantin; G. Conti; A. Contu; G. Corti; G. A. Cowan; B. D'Almagne; C. D'Ambrosio; D. G. d'Enterria; W. Da Silva; P. David; I. De Bonis; S. De Capua; M. De Cian; F. De Lorenzi; J. M. De Miranda; L. De Paula; P. De Simone; H. De Vries; D. Decamp; H. Degaudenzi; M. Deissenroth; L. Del Buono; C. Deplano; O. Deschamps; F. Dettori; J. Dickens; H. Dijkstra; M. Dima; S. Donleavy; A. C. dos Reis; A. Dovbnya; T. Du Pree; P. -Y. Duval; L. Dwyer; R. Dzhelyadin; C. Eames; S. Easo; U. Egede; V. Egorychev; F. Eisele; S. Eisenhardt; L. Eklund; D. Esperante Pereira; L. Estve; S. Eydelman; E. Fanchini; C. Frber; G. Fardell; C. Farinelli; S. Farry; V. Fave; V. Fernandez Albor; M. Ferro-Luzzi; S. Filippov; C. Fitzpatrick; F. Fontanelli; R. Forty; M. Frank; C. Frei; M. Frosini; J. L. Fungueirino Pazos; S. Furcas; A. Gallas Torreira; D. Galli; M. Gandelman; Y. Gao; J-C. Garnier; L. Garrido; C. Gaspar; N. Gauvin; M. Gersabeck; T. Gershon; Ph. Ghez; V. Gibson; Yu. Gilitsky; V. V. Gligorov; C. Gbel; D. Golubkov; A. Golutvin; A. Gomes; M. Grabalosa Gndara; R. Graciani Diaz; L. A. Granado Cardoso; E. Graugs; G. Graziani; A. Grecu; G. Guerrer; E. Gushchin; Yu. Guz; Z. Guzik; T. Gys; F. Hachon; G. Haefeli; S. C. Haines; T. Hampson; S. Hansmann-Menzemer; R. Harji; N. Harnew; P. F. Harrison; J. He; K. Hennessy; P. Henrard; J. A. Hernando Morata; A. Hicheur; E. Hicks; W. Hofmann; K. Holubyev; P. Hopchev; W. Hulsbergen; P. Hunt; T. Huse; R. S. Huston; D. Hutchcroft; V. Iakovenko; C. Iglesias Escudero; J. Imong; R. Jacobsson; M. Jahjah Hussein; E. Jans; F. Jansen; P. Jaton; B. Jean-Marie; M. John; C. R. Jones; B. Jost; F. Kapusta; T. M. Karbach; J. Keaveney; U. Kerzel; T. Ketel; A. Keune; S. Khalil; B. Khanji; Y. M. Kim; M. Knecht; J. Knopf; S. Koblitz; A. Konoplyannikov; P. Koppenburg; I. Korolko; A. Kozlinskiy; M. Krasowski; L. Kravchuk; P. Krokovny; K. Kruzelecki; M. Kucharczyk; I. Kudryashov; T. Kvaratskheliya; D. Lacarrere; A. Lai; R. W. Lambert; G. Lanfranchi; C. Langenbruch; T. Latham; R. Le Gac; R. Lefevre; A. Leflat; J. Lefranois; O. Leroy; K. Lessnoff; L. Li; Y. Y. Li; J. Libby; M. Lieng; R. Lindner; S. Lindsey; C. Linn; B. Liu; G. Liu; J. H. Lopes; E. Lopez Asamar; J. Luisier; F. Machefert; I. Machikhiliyan; F. Maciuc; O. Maev; J. Magnin; A. Maier; R. M. D. Mamunur; G. Manca; G. Mancinelli; N. Mangiafave; U. Marconi; F. Marin; J. Marks; G. Martellotti; A. Martens; L. Martin; D. Martinez Santos; Z. Mathe; C. Matteuzzi; V. Matveev; A. Mazurov; G. McGregor; B. Mcharek; C. Mclean; R. McNulty; M. Merk; J. Merkel; M. Merkin; R. Messi; F. C. D. Metlica; J. Michalowski; S. Miglioranzi; M. -N. Minard; S. Monteil; D. Moran; J. V. Morris; R. Mountain; I. Mous; F. Muheim; R. Muresan; F. Murtas; B. Muryn; M. Musy; J. Mylroie-Smith; P. Naik; T. Nakada; R. Nandakumar; J. Nardulli; Z. Natkaniec; M. Nedos; M. Needham; N. Neufeld; L. Nicolas; S. Nies; V. Niess; N. Nikitin; A. Noor; A. Oblakowska-Mucha; V. Obraztsov; S. Oggero; O. Okhrimenko; R. Oldeman; M. Orlandea; A. Ostankov; J. Palacios; M. Palutan; J. Panman; A. Papadelis; A. Papanestis; M. Pappagallo; C. Parkes; G. Passaleva; G. D. Patel; M. Patel; S. K. Paterson; G. N. Patrick; E. Pauna; C. Pauna; C. Pavel; A. Pazos Alvarez; A. Pellegrino; G. Penso; M. Pepe Altarelli; S. Perazzini; D. L. Perego; A. Prez-Calero Yzquierdo; E. Perez Trigo; P. Perret; G. Pessina; A. Petrella; A. Petrolini; B. Pietrzyk; D. Pinci; S. Playfer; M. Plo Casasus; G. Polok; A. Poluektov; E. Polycarpo; D. Popov; B. Popovici; S. Poss; C. Potterat; A. Powell; S. Pozzi; V. Pugatch; A. Puig Navarro; W. Qian; J. H. Rademacker; B. Rakotomiaramanana; I. Raniuk; G. Raven; S. Redford; W. Reece

2010-11-23T23:59:59.000Z

146

www.defra.gov.uk Environmental Key  

E-Print Network [OSTI]

that good environmental performance makes good business sense. Environmental risks and uncertainties impact. These Guidelines seek to help companies report their environmental impacts in a meaningful and cost-effective waywww.defra.gov.uk Environmental Key Performance Indicators Reporting Guidelines for UK Business #12

147

2 Key Achievements 7 Greenhouse Gas Reduction  

E-Print Network [OSTI]

Princeton University Reports Contents 2 Key Achievements 7 Greenhouse Gas Reduction Campus Energy was established in 2008, the University has invested $5.3 million in energy-savings projects, resulting in annual of a 5.2-megawatt solar collector field. · Audit the remaining 20 of the top 50 energy- consuming

148

Rangeland ecology: Key global research issues & questions  

E-Print Network [OSTI]

1 Rangeland ecology: Key global research issues & questions Robin Reid and Maria Fernandez-Gimenez This paper discusses developments in our understanding about rangeland ecology and rangeland dynamics in the last 20 years. Before the late 1980's, the mainstream view in range ecology was that livestock

149

Rangeland ecology: Key global research issues & questions  

E-Print Network [OSTI]

1 Rangeland ecology: Key global research issues & questions Robin Reid1 and Maria Fernandez Ecology Lab 2Associate Professor Colorado State University, Fort Collins, Colorado, USA Global Issues and Questions in Rangeland Ecology · Despite the focus here on global issues, we need to recognize that Mongolia

150

Key Management Challenges in Smart Grid  

SciTech Connect (OSTI)

Agenda Awarded in February 2011 Team of industry and research organizations Project Objectives Address difficult issues Complexity Diversity of systems Scale Longevity of solution Participate in standards efforts and working groups Develop innovative key management solutions Modeling and simulation ORNL Cyber Security Econometric Enterprise System Demonstrate effectiveness of solution Demonstrate scalability

Sheldon, Frederick T [ORNL] [ORNL; Duren, Mike [Sypris Electronics, LLC] [Sypris Electronics, LLC

2012-01-01T23:59:59.000Z

151

Title: Early and global estimation of microvascular target organ damage in hypertension by use of innovative software  

E-Print Network [OSTI]

Title: Early and global estimation of microvascular target organ damage in hypertension by use-mail: artriant@hotmail.com Disclosure: none Conflicts of interest: none Key Words: hypertension, target organ cardiovascular risk assessment and early #12;identification of hypertensive target organ damage is continuously

Markatos, Evangelos P.

152

Experimental quantum key distribution with finite-key security analysis for noisy channels  

E-Print Network [OSTI]

In quantum key distribution implementations, each session is typically chosen long enough so that the secret key rate approaches its asymptotic limit. However, this choice may be constrained by the physical scenario, as in the perspective use with satellites, where the passage of one terminal over the other is restricted to a few minutes. Here we demonstrate experimentally the extraction of secure keys leveraging an optimal design of the prepare-and-measure scheme, according to recent finite-key theoretical tight-bounds. The experiment is performed in different channel conditions, and assuming two distinct attack models: individual attacks, or general quantum attacks. The request on the number of exchanged qubits is then obtained as a function of the key size and of the ambient quantum bit error rate. The results indicate that viable conditions for effective symmetric, and even one-time-pad, cryptography are achievable.

Davide Bacco; Matteo Canale; Nicola Laurenti; Giuseppe Vallone; Paolo Villoresi

2014-06-17T23:59:59.000Z

153

Targeting Cancer More Effectively CR@B brings together researchers from across the University and the Royal United Hospital, Bath.  

E-Print Network [OSTI]

Targeting Cancer More Effectively CR@B brings together researchers from across the University to find a cure for various types of cancer. 40 academic groups from nearly every department to bedside and back again. Drug Discovery The discovery of a new family of anti-cancer drugs called steroid

Burton, Geoffrey R.

154

Targeting nanodisks via a single chain variable antibody - Apolipoprotein chimera  

SciTech Connect (OSTI)

Nanodisks (ND) are nanometer scale complexes of phospholipid and apolipoprotein that have been shown to function as drug delivery vehicles. ND harboring significant quantities of the antifungal agent, amphotericin B, or the bioactive isoprenoid, all trans retinoic acid, have been generated and characterized. As currently formulated, ND possess limited targeting capability. In this study, we constructed a single chain variable antibody (scFv).apolipoprotein chimera and assessed the ability of this fusion protein to form ND and recognize the antigen to which the scFv is directed. Data obtained revealed that {alpha}-vimentin scFv.apolipoprotein A-I is functional in ND formation and antigen recognition, opening the door to the use of such chimeras in targeting drug-enriched ND to specific tissues.

Iovannisci, David M.; Beckstead, Jennifer A. [Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609 (United States); Ryan, Robert O. [Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609 (United States)], E-mail: rryan@chori.org

2009-02-06T23:59:59.000Z

155

Chemical and Petroleum Engineering Key and Lab Space Agreement  

E-Print Network [OSTI]

Chemical and Petroleum Engineering Key and Lab Space Agreement Key Holder Information Last Name and Petroleum Engineering remain the property of the Department. I agree to pay a deposit for the keys

Calgary, University of

156

Drug delivery by organ-specific immunoliposomes  

SciTech Connect (OSTI)

Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside GM{sub 1} to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed. 25 refs., 5 figs.

Maruyama, Kazuo; Mori, Atsuhide; Hunag, Leaf (Tennessee Univ., Knoxville, TN (USA). Dept. of Biochemistry); Kennel, S.J. (Oak Ridge National Lab., TN (USA))

1990-01-01T23:59:59.000Z

157

Key Physical Mechanisms in Nanostructured Solar Cells  

SciTech Connect (OSTI)

The objective of the project was to study both theoretically and experimentally the excitation, recombination and transport properties required for nanostructured solar cells to deliver energy conversion efficiencies well in excess of conventional limits. These objectives were met by concentrating on three key areas, namely, investigation of physical mechanisms present in nanostructured solar cells, characterization of loss mechanisms in nanostructured solar cells and determining the properties required of nanostructured solar cells in order to achieve high efficiency and the design implications.

Dr Stephan Bremner

2010-07-21T23:59:59.000Z

158

Three key elements necessary for successful testing  

SciTech Connect (OSTI)

Real-time surface readout during data acquisition, downhole shutting, and appropriate pressure gauges are three key elements for successful well tests. These elements are often overlooked in designing and implementing a successful well test. This second in a series of three articles on well testing shows how these elements affected the testing of an example well. Also reviewed are the capabilities of several new testing tools and techniques.

Ehlig-Economides, C.A.; Hegeman, P. (Schlumberger Oilfield Services, Houston, TX (United States)); Clark, G. (Schlumberger Oilfield Services, Aberdeen (United Kingdom))

1994-07-25T23:59:59.000Z

159

Microfabricated injectable drug delivery system  

DOE Patents [OSTI]

A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

2002-01-01T23:59:59.000Z

160

Midstream Infrastructure Improvements Key to Realizing Full Potential...  

Office of Environmental Management (EM)

Midstream Infrastructure Improvements Key to Realizing Full Potential of Domestic Natural Gas Midstream Infrastructure Improvements Key to Realizing Full Potential of Domestic...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Vehicle Electrification is Key to Reducing Petroleum Dependency...  

Broader source: Energy.gov (indexed) [DOE]

Vehicle Electrification is Key to Reducing Petroleum Dependency and Greenhouse Gas Emission Vehicle Electrification is Key to Reducing Petroleum Dependency and Greenhouse Gas...

162

analysis material key: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Temperature(C) 200 2 Finite key analysis for symmetric attacks in quantum key distribution Quantum Physics (arXiv) Summary: We introduce a constructive method to calculate...

163

Sandia National Laboratories: Direct Measurement of Key Molecule...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Modeling & SimulationDirect Measurement of Key Molecule Will Increase Accuracy of Combustion Models Direct Measurement of Key Molecule Will Increase Accuracy of Combustion...

164

Flight Path Target 2  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest Region service area. TheEPSCI HomeTours, Programs and2 This flight2 Target 2

165

Advanced Target Effects Modeling  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation PortalScience of SignaturesAdvanced Target

166

Tips for Key Maps / Inset Maps How Do I Add a Key Maps or Inset Maps  

E-Print Network [OSTI]

Tips for Key Maps / Inset Maps How Do I Add a Key Maps or Inset Maps You need a new data frame o the properties/look of the extent rectangle Tips Index Map o Should be a simplified version of the map o Should cover at least 5X the area of the main map o Should have its own scale/coordinates/title o Main coverage

Brownstone, Rob

167

Prototype Spallation Neutron Source Rotating Target Assembly Final Test Report  

SciTech Connect (OSTI)

A full-scale prototype of an extended vertical shaft, rotating target assembly based on a conceptual target design for a 1 to 3-MW spallation facility was built and tested. Key elements of the drive/coupling assembly implemented in the prototype include high integrity dynamic face seals, commercially available bearings, realistic manufacturing tolerances, effective monitoring and controls, and fail-safe shutdown features. A representative target disk suspended on a 3.5 meter prototypical shaft was coupled with the drive to complete the mechanical tests. Successful operation for 5400 hours confirmed the overall mechanical feasibility of the extended vertical shaft rotating target concept. The prototype system showed no indications of performance deterioration and the equipment did not require maintenance or relubrication.

McManamy, Thomas J [ORNL; Graves, Van [Oak Ridge National Laboratory (ORNL); Garmendia, Amaia Zarraoa [IDOM Bilbao; Sorda, Fernando [ESS Bilbao; Etxeita, Borja [IDOM Bilbao; Rennich, Mark J [ORNL

2011-01-01T23:59:59.000Z

168

antirheumatic drugs dmards: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

169

antineoplastic drugs: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

170

antineoplastic drugs chimio-radiotherapie: Topics by E-print...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

171

Rotating Target Development for SNS Second Target Station  

SciTech Connect (OSTI)

A rotating target for the second target station (STS) at SNS has been identified as an option along with a mercury target. Evaluation of the rotating target alternative for STS has started at 1.5 MW which is considered an upper bound for the power. Previous preconceptual design work for a 3 MW rotating target is being modified for the lower power level. Transient thermal analysis for a total loss of active water cooling has been done for a simplified 2D model of the target and shielding monolith which shows that peak temperatures are well below the level at which tungsten vaporization by steam could exceed site boundary dose limits. Design analysis and integration configuration studies have been done for the target-moderator-reflector assembly which maximizes the number of neutron beam lines and provides for replacement of the target and moderators. Target building hot cell arrangement for this option will be described. An option for operation in rough vacuum without a proton beam window using Ferro fluid seals on a vertical shaft is being developed. A full scale prototypic drive module based on the 3 MW preconceptual design has been fabricated and successfully tested with a shaft and mock up target supplied by the ESS-Bilbao team. Overall planning leading to decision between mercury and the rotating target in 2011 will be discussed

McManamy, Thomas J [ORNL; Rennich, Mark J [ORNL; Crawford, Roy K [ORNL; Geoghegan, Patrick J [ORNL; Janney, Jim G [ORNL

2010-01-01T23:59:59.000Z

172

Quantum key distribution with entangled photon sources  

E-Print Network [OSTI]

A parametric down-conversion (PDC) source can be used as either a triggered single photon source or an entangled photon source in quantum key distribution (QKD). The triggering PDC QKD has already been studied in the literature. On the other hand, a model and a post-processing protocol for the entanglement PDC QKD are still missing. In this paper, we fill in this important gap by proposing such a model and a post-processing protocol for the entanglement PDC QKD. Although the PDC model is proposed to study the entanglement-based QKD, we emphasize that our generic model may also be useful for other non-QKD experiments involving a PDC source. Since an entangled PDC source is a basis independent source, we apply Koashi-Preskill's security analysis to the entanglement PDC QKD. We also investigate the entanglement PDC QKD with two-way classical communications. We find that the recurrence scheme increases the key rate and Gottesman-Lo protocol helps tolerate higher channel losses. By simulating a recent 144km open-air PDC experiment, we compare three implementations -- entanglement PDC QKD, triggering PDC QKD and coherent state QKD. The simulation result suggests that the entanglement PDC QKD can tolerate higher channel losses than the coherent state QKD. The coherent state QKD with decoy states is able to achieve highest key rate in the low and medium-loss regions. By applying Gottesman-Lo two-way post-processing protocol, the entanglement PDC QKD can tolerate up to 70dB combined channel losses (35dB for each channel) provided that the PDC source is placed in between Alice and Bob. After considering statistical fluctuations, the PDC setup can tolerate up to 53dB channel losses.

Xiongfeng Ma; Chi-Hang Fred Fung; Hoi-Kwong Lo

2007-03-14T23:59:59.000Z

173

Keyes, California: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429 Throttled (botOpen6Kentwood, Michigan: EnergyKesona PowerStatistics-2010Keyes,

174

Key Renewable Energy Opportunities for Oklahoma Tribes  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel2007 | Department7JanuaryWASTE-TO-ENERGY:About »KEY RENEWABLE

175

Fermilab | Science | Particle Physics | Key Discoveries  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest Region service area. TheEPSCI Home ItDarkDiscoveries WorldwideDarkKey

176

Another key Y-12 General Foreman remembered  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout theOFFICEAmes Laboratory Site|Andrea4»Another key Y-12 General

177

Target Diagnostics Supports NIF's Path to Ignition  

SciTech Connect (OSTI)

The physics requirements derived from the National Ignition Facility (NIF) experimental campaigns are leading to a wide variety of target diagnostics. Software development for the control and analysis of these diagnostics is included in the NIF Integrated Computer Control System, Diagnostic Control System and Data Visualization. These projects implement the configuration, controls, data analysis and visual representation of most of these diagnostics. To date, over 40 target diagnostics have been developed to support NIF experiments. In 2011 diagnostics were developed or enhanced to measure Ignition performance in a high neutron yield environment. Performance is optimized around four key variables: Adiabat (a) which is the strength and timing of four shocks delivered to the target, Velocity (V) of the imploding target, Mix (M) is the uniformity of the burn, and the Shape (S) of the imploding Deuterium Tritium (DT) hot spot. The diagnostics used to measure each of these parameters is shown in figure 1. Adiabat is measured using the Velocity Interferometer System for Any Reflector (VISAR) diagnostic consisting of three streak cameras. To provide for more accurate adiabat measurements the VISAR streak cameras were enhanced in FY11 with a ten comb fiducial signal controller to allow for post shot correction of the streak camera sweep non-linearity. Mix is measured by the Neutron Time of Flight (NTOF) and Radiochemical Analysis of Gaseous Samples (RAGS) diagnostics. To accommodate high neutron yield shots, NTOF diagnostic controls are being modified to use Mach Zehnder interferometer signals to allow the digitizers to be moved from near the target chamber to the neutron shielded diagnostic mezzanine. In December 2011 the first phase of RAGS diagnostic commissioning will be completed. This diagnostic will analyze the tracers that are added to NIF target capsules that undergo nuclear reactions during the shot. These gases are collected and purified for nuclear counting by the RAGS system. Three new instrument controllers were developed and commissioned to support this diagnostic. A residual-gas analyzer (RGA) instrument measures the gas content at various points in the system. The Digital Gamma Spectrometer instrument measures the radiological spectrum of the decaying gas isotopes. A final instrument controller was developed to interface to a PLC based Gas collection system. In order to support the implosion velocity measurements an additional Gated X-ray Detector (GXD) diagnostic was tested and commissioned. This third GXD views the target through a slit contained in its snout and allows the other GXD diagnostics to be used for measuring the shape on the same shot. In order to measure the implosion shape in a high neutron environment, Actide Readout In A Neutron Environment (ARIANE) and Neutron Imaging (NI) diagnostics were commissioned. The controls for ARIANE, a fixed port gated x-ray imager, contain a neutron shielded camera and micro channel plate pulser with its neutron sensitive electronics located in the diagnostic mezzanine. The NI diagnostic is composed of two Spectral Instruments SI-1000 cameras located 20M from the target and provides neutron images of the DT hot spot for high yield shots. The development and commissioning of these new or enhanced diagnostics in FY11 have provided meaningful insight that facilitates the optimization of the four key Ignition variables. In FY12 they will be adding three new diagnostics and enhancing four existing diagnostics in support of the continuing optimization series of campaigns.

Shelton, R

2011-12-07T23:59:59.000Z

178

Quantum key distribution with entangled photon sources  

E-Print Network [OSTI]

A parametric down-conversion (PDC) source can be used as either a triggered single photon source or an entangled photon source in quantum key distribution (QKD). The triggering PDC QKD has already been studied in the literature. On the other hand, a model and a post-processing protocol for the entanglement PDC QKD are still missing. In this paper, we fill in this important gap by proposing such a model and a post-processing protocol for the entanglement PDC QKD. Although the PDC model is proposed to study the entanglement-based QKD, we emphasize that our generic model may also be useful for other non-QKD experiments involving a PDC source. Since an entangled PDC source is a basis independent source, we apply Koashi-Preskill's security analysis to the entanglement PDC QKD. We also investigate the entanglement PDC QKD with two-way classical communications. We find that the recurrence scheme increases the key rate and Gottesman-Lo protocol helps tolerate higher channel losses. By simulating a recent 144km open-a...

Ma, X; Lo, H K; Ma, Xiongfeng; Fung, Chi-Hang Fred; Lo, Hoi-Kwong

2007-01-01T23:59:59.000Z

179

PDFs for nuclear targets  

E-Print Network [OSTI]

Understanding nuclear effects in parton distribution functions (PDF) is an essential component needed to determine the strange and anti-strange quark contributions in the proton. In addition Nuclear Parton Distribution Functions (NPDF) are critically important for any collider experiment with nuclei (e.g. RHIC, ALICE). Here two next-to-leading order chi^2-analyses of NPDF are presented. The first uses neutral current charged-lepton Deeply Inelastic Scattering (DIS) and Drell-Yan data for several nuclear targets and the second uses neutrino-nucleon DIS data. We compare the nuclear corrections factors (F_2^Fe/F_2^D) for the charged-lepton data with other results from the literature. In particular, we compare and contrast fits based upon the charged-lepton DIS data with those using neutrino-nucleon DIS data.

Karol Kovarik

2010-06-25T23:59:59.000Z

180

ORION laser target diagnostics  

SciTech Connect (OSTI)

The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

Bentley, C. D.; Edwards, R. D.; Andrew, J. E.; James, S. F.; Gardner, M. D.; Comley, A. J.; Vaughan, K.; Horsfield, C. J.; Rubery, M. S.; Rothman, S. D.; Daykin, S.; Masoero, S. J.; Palmer, J. B.; Meadowcroft, A. L.; Williams, B. M.; Gumbrell, E. T.; Fyrth, J. D.; Brown, C. R. D.; Hill, M. P.; Oades, K. [Plasma Physics Department, Atomic Weapons Establishment, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom); and others

2012-10-15T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Seismic technology will be of key importance for evaluat-ing gas-hydrate resources, particularly across the Gulf of  

E-Print Network [OSTI]

Seismic technology will be of key importance for evaluat- ing gas-hydrate resources, particularly to be acquired. To apply seismic technology to gas-hydrate studies in the gulf in an optimal manner, it is essential to understand the seismic target that has to be analyzed. What is gas hydrate? Gas hydrate

Texas at Austin, University of

182

The OLYMPUS Internal Hydrogen Target  

E-Print Network [OSTI]

An internal hydrogen target system was developed for the OLYMPUS experiment at DESY, in Hamburg, Germany. The target consisted of a long, thin-walled, tubular cell within an aluminum scattering chamber. Hydrogen entered at the center of the cell and exited through the ends, where it was removed from the beamline by a multistage pumping system. A cryogenic coldhead cooled the target cell to counteract heating from the beam and increase the density of hydrogen in the target. A fixed collimator protected the cell from synchrotron radiation and the beam halo. A series of wakefield suppressors reduced heating from beam wakefields. The target system was installed within the DORIS storage ring and was successfully operated during the course of the OLYMPUS experiment in 2012. Information on the design, fabrication, and performance of the target system is reported.

J. C. Bernauer; V. Carassiti; G. Ciullo; B. S. Henderson; E. Ihloff; J. Kelsey; P. Lenisa; R. Milner; A. Schmidt; M. Statera

2014-04-02T23:59:59.000Z

183

Photosensitizer Conjugates For Pathogen Targeting  

SciTech Connect (OSTI)

Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.

Hasan, Tayyaba (Arlington, MA); Hamblin, Michael R. (Revere, MA); Soukos, Nikos (Revere, MA)

2002-10-08T23:59:59.000Z

184

POLARIZED TARGET EXPERIMENT AT FERMILAB  

E-Print Network [OSTI]

on Experiment 61 at Fermilab, which is a large collaborationBernie Sandler, From From Fermilab. Alan Jonckheere andTARGET EXPERIMENT AT FERMILAB Owen Chamberlain January 1977

Chamberlain, O.

2010-01-01T23:59:59.000Z

185

Target Space Duality III: Potentials  

E-Print Network [OSTI]

We generalize previous results on target space duality to the case where there are background fields and the sigma model lagrangian has a potential function.

Orlando Alvarez; Blazej Ruszczycki

2007-12-31T23:59:59.000Z

186

Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang,  

E-Print Network [OSTI]

Chapter 11 Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang, Robert Langer, and Omid C. Farokhzad Abstract The use of biodegradable polymeric nanoparticles. In cancer, targeted polymeric NPs can be used to deliver chemotherapies to tumor cells with greater efficacy

Zhang, Liangfang

187

Compression station key to Texas pipeline project  

SciTech Connect (OSTI)

This was probably the largest pipeline project in the US last year, and the largest in Texas in the last decade. The new compressor station is a key element in this project. TECO, its servicing dealer, and compression packager worked closely throughout the planning and installation stages of the project. To handle the amount of gas required, TECO selected the GEMINI F604-1 compressor, a four-throw, single-stage unit with a six-inch stroke manufactured by Weatherford Enterra Compression Co. (WECC) in Corpus Christi, TX. TECO also chose WECC to package the compressors. Responsibility for ongoing support of the units will be shared among TECO, the service dealer and the packager. TECO is sending people to be trained by WECC, and because the G3600 family of engines is still relatively new, both the Caterpillar dealer and WECC sent people for advanced training at Caterpillar facilities in Peoria, IL. As part of its service commitment to TECO, the servicing dealer drew up a detailed product support plan, encompassing these five concerns: Training, tooling; parts support; service support; and commissioning.

NONE

1996-10-01T23:59:59.000Z

188

A probabilistic approach to microRNA-target binding  

SciTech Connect (OSTI)

Highlights: {yields} A new probabilistic model is introduced for microRNA-target binding. {yields} The new model significantly outperforms RNAHybrid and miRTif. {yields} The experiments can unveil the effects of the type and directions of distinct base pairings. -- Abstract: Elucidation of microRNA activity is a crucial step in understanding gene regulation. One key problem in this effort is how to model the pairwise interactions of microRNAs with their targets. As this interaction is strongly mediated by their sequences, it is desired to set-up a probabilistic model to explain the binding preferences between a microRNA sequence and the sequence of a putative target. To this end, we introduce a new model of microRNA-target binding, which transforms an aligned duplex to a new sequence and defines the likelihood of this sequence using a Variable Length Markov Chain. It offers a complementary representation of microRNA-mRNA pairs for microRNA target prediction tools or other probabilistic frameworks of integrative gene regulation analysis. The performance of present model is evaluated by its ability to predict microRNA-target mRNA interaction given a mature microRNA sequence and a putative mRNA binding site. In regard to classification accuracy, it outperforms two recent methods based on thermodynamic stability and sequence complementarity. The experiments can also unveil the effects of base pairing types and non-seed region in duplex formation.

Ogul, Hasan, E-mail: hogul@baskent.edu.tr [Department of Computer Engineering, Baskent University, Baglica TR-06810, Ankara (Turkey)] [Department of Computer Engineering, Baskent University, Baglica TR-06810, Ankara (Turkey); Umu, Sinan U. [Department of Chemistry, Middle East Technical University, Cankaya TR-06800, Ankara (Turkey) [Department of Chemistry, Middle East Technical University, Cankaya TR-06800, Ankara (Turkey); Bioinformatics Program, Informatics Institute, Middle East Technical University, Cankaya TR-06800, Ankara (Turkey); Tuncel, Y. Yener [Bioinformatics Program, Informatics Institute, Middle East Technical University, Cankaya TR-06800, Ankara (Turkey)] [Bioinformatics Program, Informatics Institute, Middle East Technical University, Cankaya TR-06800, Ankara (Turkey); Akkaya, Mahinur S. [Department of Chemistry, Middle East Technical University, Cankaya TR-06800, Ankara (Turkey)] [Department of Chemistry, Middle East Technical University, Cankaya TR-06800, Ankara (Turkey)

2011-09-16T23:59:59.000Z

189

Realizing Technologies for Magnetized Target Fusion  

SciTech Connect (OSTI)

Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

Wurden, Glen A. [Los Alamos National Laboratory

2012-08-24T23:59:59.000Z

190

The impacts of urbanization on endangered florida key deer  

E-Print Network [OSTI]

for resources between man and wildlife continues, it is important to understand the effects of urbanization on species. Endangered Key deer (Odocoileus virginianus clavium) are endemic to the Florida Keys archipelago stretching southwest off the southern tip...

Harveson, Patricia Moody

2006-04-12T23:59:59.000Z

191

actual key success: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

key exchange over an insecure channel. The security of the proposed algorithm grows as NPm, where M, P are the size of the key and the computational commplexity fo the linear...

192

Updated distribution and reintroduction of the Lower Keys marsh rabbit  

E-Print Network [OSTI]

Listed as federally-endangered in 1990, the Lower Keys marsh rabbit (LKMR, Sylvilagus palustris hefneri) exists as a metapopulation in patches of wetland habitat in Florida?s Lower Keys. This study sought to address 2 priority actions identified...

Faulhaber, Craig Alan

2005-02-17T23:59:59.000Z

193

authenticated key agreement: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

desirable attributes. Index Terms--Mutual Authentication; Key Management; SRP; Security; Smart Meter; Smart Leung, Victor C.M. 53 On the security of some password-based key...

194

Exploring the context : a small hotel in Key West  

E-Print Network [OSTI]

This thesis develops a personal method and approach for designing in a delicate context such as the Key West Historic District. This thesis is composed of two parts. The first part presents observations of Key West, focusing ...

VanBeuzekom, Edrick

1984-01-01T23:59:59.000Z

195

Residential Energy Efficiency Financing: Key Elements of Program Design  

Broader source: Energy.gov [DOE]

Presents key programmatic elements and context of financing initiatives, including contractor support, rebates, quality assurance, and more.

196

VERTEX CHAMBERS TARGET CELL CALORIMETER  

E-Print Network [OSTI]

DRIFT VC 1/2 FC 1/2 VERTEX CHAMBERS TARGET CELL DVC MC 13 HODOSCOPE H0 MONITOR BC 1/2 BC 3/4 TRD at Threashold Lambda Physics (u L spin transfer) Motivation: W L Target cell e beam L p p e Elastic: Peltier elements ( T ~ 20C ) Custom built electronics + HELIX chips low autgassing (

197

Polypharmacology Modelling Using Proteochemometrics (PCM): Recent Methodological Developments, Applications to Target Families, and Future Prospects  

E-Print Network [OSTI]

to be in the order of $1.8 billion per drug. In addition, price pressure from health care providers has been increasing and there is a growing relevance of more targeted medicine. Hence, the blockbuster model of the pharmaceutical industry is being challenged.1...

Corts-Ciriano, Isidro; ul Ain, Qurrat; Subramanian, Vigneshwari; Lenselink, Eelke B.; Mndez-Lucio, Oscar; IJzerman, Adriaan P.; Wohlfahrt, Gerd; Prusis, Peteris; Malliavin, Thrse E.; van Westen, Gerard J. P.; Bender, Andreas

2014-10-07T23:59:59.000Z

198

A Full Key Recovery Attack on HMAC-AURORA-512  

E-Print Network [OSTI]

A Full Key Recovery Attack on HMAC-AURORA-512 Yu Sasaki NTT Information Sharing Platform.yu@lab.ntt.co.jp Abstract. In this note, we present a full key recovery attack on HMAC- AURORA-512 when 512-bit secret keys is 2259 AURORA-512 operations, which is significantly less than the complexity of the exhaustive search

199

Magnetized Target Fusion Collaboration. Final report  

SciTech Connect (OSTI)

Nuclear fusion has the potential to satisfy the prodigious power that the world will demand in the future, but it has yet to be harnessed as a practical energy source. The entry of fusion as a viable, competitive source of power has been stymied by the challenge of finding an economical way to provide for the confinement and heating of the plasma fuel. It is the contention here that a simpler path to fusion can be achieved by creating fusion conditions in a different regime at small scale (~ a few cm). One such program now under study, referred to as Magnetized Target Fusion (MTF), is directed at obtaining fusion in this high energy density regime by rapidly compressing a compact toroidal plasmoid commonly referred to as a Field Reversed Configuration (FRC). To make fusion practical at this smaller scale, an efficient method for compressing the FRC to fusion gain conditions is required. In one variant of MTF a conducting metal shell is imploded electrically. This radially compresses and heats the FRC plasmoid to fusion conditions. The closed magnetic field in the target plasmoid suppresses the thermal transport to the confining shell, thus lowering the imploding power needed to compress the target. The undertaking described in this report was to provide a suitable target FRC, as well as a simple and robust method for inserting and stopping the FRC within the imploding liner. The FRC must also survive during the time it takes for the metal liner to compress the FRC target. The initial work at the UW was focused on developing adequate preionization and flux trapping that were found to be essential in past experiments for obtaining the density, flux and most critically, FRC lifetime required for MTF. The timescale for testing and development of such a source can be rapidly accelerated by taking advantage of a new facility funded by the Department of Energy. At this facility, two inductive plasma accelerators (IPA) were constructed and tested. Recent experiments with these IPAs have demonstrated the ability to rapidly form, accelerate and merge two hypervelocity FRCs into a compression chamber. The resultant FRC that was formed was hot (T{sub ion} ~ 400 eV), stationary, and stable with a configuration lifetime several times that necessary for the MTF liner experiments. The accelerator length was less than 1 meter, and the time from the initiation of formation to the establishment of the final equilibrium was less than 10 microseconds. With some modification, each accelerator can be made capable of producing FRCs suitable for the production of the target plasma for the MTF liner experiment. Based on the initial FRC merging/compression results, the design and methodology for an experimental realization of the target plasma for the MTF liner experiment can now be defined. The construction and testing of the key components for the formation of the target plasma at the Air Force Research Laboratory (AFRL) will be performed on the IPA experiment, now at MSNW. A high density FRC plasmoid will be formed and accelerated out of each IPA into a merging/compression chamber similar to the imploding liner at AFRL. The properties of the resultant FRC plasma (size, temperature, density, flux, lifetime) will be obtained. The process will be optimized, and a final design for implementation at AFRL will be carried out. When implemented at AFRL it is anticipated that the colliding/merging FRCs will then be compressed by the liner. In this manner it is hoped that ultimately a plasma with ion temperatures reaching the 10 keV range and fusion gain near unity can be obtained.

John Slough

2012-04-18T23:59:59.000Z

200

Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug  

E-Print Network [OSTI]

Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

Carlyle, Wenda C.

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

K:\\Operations\\Forms\\201 Key or Vendor Card Request.pdf Rev ASU DPc Key/Vendor Card Request  

E-Print Network [OSTI]

K:\\Operations\\Forms\\201 Key or Vendor Card Request.pdf Rev ASU DPc Key/Vendor Card Request Complete/Staff Undergrad Grad Asst Other Department or Vendor PO # or Agency/ORG Mail Code Affiliation (place X in one box am personally accountable for all ASU keys/vendor cards issued to me. I understand that only I am

Rhoads, James

202

antiepileptic drug effects: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

203

IPNS enriched uranium booster target  

SciTech Connect (OSTI)

Since startup in 1981, IPNS has operated on a fully depleted /sup 238/U target. With the booster as in the present system, high energy protons accelerated to 450 MeV by the Rapid Cycling Synchrotron are directed at the target and by mechanisms of spallation and fission of the uranium, produce fast neutrons. The neutrons from the target pass into adjacent moderator where they slow down to energies useful for spectroscopy. The target cooling systems and monitoring systems have operated very reliably and safely during this period. To provide higher neutron intensity, we have developed plans for an enriched uranium (booster) target. HETC-VIM calculations indicate that the target will produce approx.90 kW of heat, with a nominal x5 gain (k/sub eff/ = 0.80). The neutron beam intensity gain will be a factor of approx.3. Thermal-hydraulic and heat transport calculations indicate that approx.1/2 in. thick /sup 235/U discs are subject to about the same temperatures as the present /sup 238/U 1 in. thick discs. The coolant will be light demineralized water (H/sub 2/O) and the coolant flow rate must be doubled. The broadening of the fast neutron pulse width should not seriously affect the neutron scattering experiments. Delayed neutrons will appear at a level about 3% of the total (currently approx.0.5%). This may affect backgrounds in some experiments, so that we are assessing measures to control and correct for this (e.g., beam tube choppers). Safety analyses and neutronic calculations are nearing completion. Construction of the /sup 235/U discs at the ORNL Y-12 facility is scheduled to begin late 1985. The completion of the booster target and operation are scheduled for late 1986. No enriched uranium target assembly operating at the projected power level now exists in the world. This effort thus represents an important technological experiment as well as being a ''flux enhancer''.

Schulke, A.W. Jr.

1985-01-01T23:59:59.000Z

204

Fake state attack on practically decoy state quantum key distribution  

E-Print Network [OSTI]

In this paper, security of practically decoy state quantum key distribution under fake state attack is considered. If quantum key distribution is insecure under this type of attack, decoy sources can not also provide it with enough security. Strictly analysis shows that Eve should eavesdrop with the aid of photon-number-resolving instruments. In practical implementation of decoy state quantum key distribution where statistical fluctuation is considered, however, Eve can attack it successfully with threshold detectors.

Yong-gang Tan

2012-02-15T23:59:59.000Z

205

QKD with finite resources: secret key rates via Rnyi entropies  

E-Print Network [OSTI]

A realistic Quantum Key Distribution (QKD) protocol necessarily deals with finite resources, such as the number of signals exchanged by the two parties. We derive a bound on the secret key rate which is expressed as an optimization problem over R\\'enyi entropies. Under the assumption of collective attacks by an eavesdropper, a computable estimate of our bound for the six-state protocol is provided. This bound leads to improved key rates in comparison to previous results.

Silvestre Abruzzo; Hermann Kampermann; Markus Mertz; Dagmar Bru

2011-05-27T23:59:59.000Z

206

Targets and methods for target preparation for radionuclide production  

DOE Patents [OSTI]

The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti--Sb, Al--Sb, Cu--Sb, or Ni--Sb in order to produce radionuclides (e.g., tin-117 m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.

Zhuikov, Boris L; Konyakhin, Nicolai A; Kokhanyuk, Vladimir M; Srivastava, Suresh C

2012-10-16T23:59:59.000Z

207

Climate Action Planning: A Review of Best Practices, Key Elements...  

Open Energy Info (EERE)

Planning: A Review of Best Practices, Key Elements, and Common Climate Strategies for Signatories to the American College & University Presidents' Climate Commitment Jump to:...

208

TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring...  

Broader source: Energy.gov (indexed) [DOE]

Radiation Monitoring Subgroup TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring Subgroup Radiation Monitoring Subgroup Draft Work Plan - February 4, 2008 More...

209

LANL breaks ground on key sediment control project  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sediment control project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately 2 million features are up to eight feet high and...

210

Hydrodynamic experiment provides key data for Stockpile Stewardship  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

predictively model and assess weapon performance in the absence of full-scale underground nuclear testing," said Webster. Los Alamos hydrodynamic experiment provides key data for...

211

Worldwide Trends in Energy Use and Efficiency: Key Insights from...  

Open Energy Info (EERE)

Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Jump to: navigation, search Tool Summary...

212

Water dynamics clue to key residues in protein folding  

SciTech Connect (OSTI)

A computational method independent of experimental protein structure information is proposed to recognize key residues in protein folding, from the study of hydration water dynamics. Based on all-atom molecular dynamics simulation, two key residues are recognized with distinct water dynamical behavior in a folding process of the Trp-cage protein. The identified key residues are shown to play an essential role in both 3D structure and hydrophobic-induced collapse. With observations on hydration water dynamics around key residues, a dynamical pathway of folding can be interpreted.

Gao, Meng [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Zhu, Huaiqiu, E-mail: hqzhu@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Yao, Xin-Qiu [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China) [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Department of Biophysics, Kyoto University, Sakyo Kyoto 606-8502 (Japan); She, Zhen-Su, E-mail: she@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)

2010-01-29T23:59:59.000Z

213

Pantex Plant Achieves Key Safety Milestone Ahead of Schedule...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Achieves Key Safety Milestone Ahead of Schedule | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing...

214

Key Practical Issues in Strengthening Safety Culture, INSAG-15  

Broader source: Energy.gov [DOE]

Key Pratical Issues in Strengthening Safety Culture, INSAG-15. A report by the International Nuclear Safety Advisory Gorup, International Atomic Energy Agency, Vienna, 2002.

215

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

less than six years. The energy audits were carried out byyears, as identified in an energy audit or through internalthe following: 86 1. Energy audit and analysis. The company

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

216

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

of companies with the Danish Energy Agency, were made forMay 29, 2003. Danish Energy Agency, 2000. Green Taxes forDanish CO 2 -Tax Scheme, in International Energy Agency,

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

217

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

quality management program (ISO 9001:2000) and environmentalquality management system (ISO 9001). It was also found that

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

218

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

implementation of the EMS is the similarity with other management systems, like environmental management system and the quality management system (ISO 9001).

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

219

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

of industrial primary energy consumption in The Netherlands.included total primary energy consumption for twelve typeswas converted into primary energy consumption and the energy

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

220

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

Incentives for Business Investments in Energy Conservation and Renewableincentives for adoption of energy efficiency and renewable

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

less than six years. The energy audits were carried out bythe following: 86 1. Energy audit and analysis. The companycertification body. (More on energy audits is contained in

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

222

Economic Life Cycle Assessment as element of sustainability certification a key success factor moving beyond Life Cycle Costing  

E-Print Network [OSTI]

Target topic: achieving sustainability, saving energy, and improving occupant comfort? Lead Author Wolfram Trinius, PhD, Ingenieurb?ro Trinius, Hamburg, Germany and University of Gavle, Sweden Co Authors Harry Hirsch, HH Consulting, Baden... Baden, Germany Simone Lakenbrink, DU Diederichs Project Management, Munich, Germany Title Economic Life Cycle Assessment as element of sustainability certification ? a key success factor moving beyond Life Cycle Costing The move from...

Trinius, W.; Hirsch, H.

223

Enterprise Assessments Targeted Review, Argonne National Laboratory...  

Energy Savers [EERE]

Targeted Review, Argonne National Laboratory - November 2014 Enterprise Assessments Targeted Review, Argonne National Laboratory - November 2014 November 2014 Review of the...

224

A Prospective Target for Advanced Biofuel Production  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A Prospective Target for Advanced Biofuel Production A Prospective Target for Advanced Biofuel Production Print Thursday, 02 February 2012 13:34 The sesquiterpene bisabolene was...

225

A battle with superbugs : New compounds and targets against drug-resistant pathogens  

E-Print Network [OSTI]

Product Marinopyrrole A against MRSA, abstr F1-1501. In 49thB. (2011). Five decades of MRSA: controversy and uncertaintyin community- associated MRSA pathogenesis. Trends Microbiol

Haste, Nina M.

2012-01-01T23:59:59.000Z

226

Structure-based drug mechanism study and inhibitor design targeting tuberculosis  

E-Print Network [OSTI]

...........................................................................................................40 Cloning, Expression and Purification ...........................................................40 Synthesis of the INH-NAD, PNH-NAD and BZH-NAD Adducts...............41 InhA Activity Assay..............................39 Figure 13 Crystal Structure of S94A Bound with the INH-NAD Adduct. ....................48 Figure 14 Synthesis of INH-NAD, BZH-NAD, and PNH-NAD...................................51 Figure 15 Surface Diagram of InhA in Complex with Hydrazide...

Wang, Feng

2009-05-15T23:59:59.000Z

227

E-Print Network 3.0 - anti-filarial drug target Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences 24 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: the Pharmaceutical Industry History,...

228

E-Print Network 3.0 - anti-epileptogenic drug targets Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences 19 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: the Pharmaceutical Industry History,...

229

Genome-Free Viral Capsids for Targeted Drug Delivery to Breast Cancer  

E-Print Network [OSTI]

Water (ddH 2 O) used in biological procedures or as a reaction solvent was deionized using a NANOpure TM purification system (Water (ddH 2 O) used in biologi- cal procedures or as a reaction solvent was deionized using a NANOpure TM purification system (

Wu, Wesley

2012-01-01T23:59:59.000Z

230

Biosynthesis pathway & transport of endotoxin - promising antibacterial drug targets in the Burkholderia cepacia Complex (BCC)  

E-Print Network [OSTI]

Burkholderia cepacia complex (Bcc) species are opportunistic pathogens in patients with cystic fibrosis (CF), which are able to cause lethal infections. The Bcc are inherently resistant to most classes of antibiotics, ...

Bodewits, Karin

2011-11-23T23:59:59.000Z

231

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells  

E-Print Network [OSTI]

The interaction between the HSP90 chaperone and its client kinases is sensitive to the conformational status of the kinase, and stabilization of the kinase fold by small molecules strongly decreases chaperone interaction. ...

Taipale, Mikko

232

E-Print Network 3.0 - applications predicting drug-target Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Beijing Collection: Computer Technologies and Information Sciences 40 Optimal Halbach permanent magnet designs for maximally pulling and pushing nanoparticles Summary: on magnetic...

233

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

D. F. , Kahl, S. B. , Bjornstad, K. A. , Bauer, W. F. ,L. , Blakely, E. A. , Bjornstad, K. A. , Deen, D. F. ,Blakely 2 , Kathleen A. Bjornstad 2 , Xiao Shu 3 ,Thomas F.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

234

CHARACTERIZATION OF MYCOSIN FAMILY PROTEASES, NOVEL DRUG TARGETS OF MYCOBACTERIUM TUBERCULOSIS  

E-Print Network [OSTI]

in the cloning process because of the conservation of the Mycosins active sites. The most potent inhibitor will be able to bind all five Mycosins. Several sequence alignments have also been included to help characterize the Mycosin-1 protein. The evidence...

Baird, Hilary

2007-09-17T23:59:59.000Z

235

A battle with superbugs : New compounds and targets against drug-resistant pathogens  

E-Print Network [OSTI]

small-scale expression (~10 ml) check on each of the four-deletion mutants was performed using a nickel- resin purification

Haste, Nina M.

2012-01-01T23:59:59.000Z

236

Progress with developing a target for magnetized target fusion  

SciTech Connect (OSTI)

Magnetized Target Fusion (MTF) is an approach to fusion where a preheated and magnetized plasma is adiabatically compressed to fusion conditions. Successful MTF requires a suitable initial target plasma with an embedded magnetic field of at least 5 T in a closed-field-line topology, a density of roughly 10{sup 18} cm{sup {minus}3}, a temperature of at least 50 eV, and must be free of impurities which would raise radiation losses. Target plasma generation experiments are underway at Los Alamos National Laboratory using the Colt facility; a 0.25 MJ, 2--3 {micro}s rise-time capacitor bank. The goal of these experiments is to demonstrate plasma conditions meeting the minimum requirements for a MTF initial target plasma. In the first experiments, a Z-pinch is produced in a 2 cm radius by 2 cm high conducting wall using a static gas-fill of hydrogen or deuterium gas in the range of 0.5 to 2 torr. Thus far, the diagnostics include an array of 12 B-dot probes, framing camera, gated OMA visible spectrometer, time-resolved monochrometer, filtered silicon photodiodes, neutron yield, and plasma-density interferometer. These diagnostics show that a plasma is produced in the containment region that lasts roughly 10 to 20 {micro}s with a maximum plasma density exceeding 10{sup 18} cm{sup {minus}3}. The experimental design and data are presented.

Wysocki, F.J.; Chrien, R.E.; Idzorek, G.; Oona, H.; Whiteson, D.O.; Kirkpatrick, R.C.; Lindemuth, I.R.; Sheehey, P.T.

1997-09-01T23:59:59.000Z

237

Energy Security: A Key Requirement forSustainable Development  

E-Print Network [OSTI]

1 Energy Security: A Key Requirement forSustainable Development Perspective and Action Plan Robert Card Under Secretary US Department of Energy August 30, 2002 Session One: Maintaining Energy Security WSSD Side Event Energy for Sustainable Development IEA/UNEP/Eskom #12;2 Energy Security is a Key

238

Prairie Fruit Summary, 2010 Some key considerations for the homeowner  

E-Print Network [OSTI]

1 Prairie Fruit Summary, 2010 Some key considerations for the homeowner by Bob Bors The following list highlights some key positive (+), negative (-) and variable ( ± ) attributes for growing fruit into account. For more info visit: www.fruit.usask.ca Haskap/Blue Honeysuckle: - All varieties are very cold

Peak, Derek

239

Efficient Hybrid Key Agreement Protocol for Wireless Ad Hoc Networks  

E-Print Network [OSTI]

Efficient Hybrid Key Agreement Protocol for Wireless Ad Hoc Networks Xiang-Yang Li Yu Wang Ophir important aspects in ad-hoc wireless networks. To ensure the security, several cryptography protocols must efficient when applied to wireless ad-hoc networks. In this paper, we propose a key agreement protocol

Wang, Yu

240

Reflective cracking of shear keys in multi-beam bridges  

E-Print Network [OSTI]

..............................................2 Figure 2: PCI 33? Box Girder with Shear Keys................................................................5 Figure 3: TxDOT 34? Box Girder with Shear Keys .........................................................5 Figure 4: Test Specimen... Under Tension.........................................................................12 Figure 5: Test Specimen in Bending ...............................................................................12 Figure 6: Test Specimen in Shear...

Sharpe, Graeme Peter

2009-06-02T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Public Key Encryption that Allows PIR Queries Eyal Kushilevitz  

E-Print Network [OSTI]

Public Key Encryption that Allows PIR Queries Dan Boneh Eyal Kushilevitz Rafail Ostrovsky William E to create a public- key encryption scheme for Alice that allows PIR searching over encrypted documents. Our allows for Single-Database PIR writing with sublinear communication complexity, which we consider

242

Public Key Encryption that Allows PIR Queries Eyal Kushilevitz  

E-Print Network [OSTI]

Public Key Encryption that Allows PIR Queries Dan Boneh Eyal Kushilevitz Rafail Ostrovsky William E. In this paper, we show how to create a public-key encryption scheme for Alice that allows PIR searching over allows for Single-Database PIR writing with sublinear communication complexity, which we consider

Ostrovsky, Rafail

243

Electricity and Development: Global Trends and Key Challenges  

E-Print Network [OSTI]

Electricity and Development: Global Trends and Key Challenges Romeo Pacudan, PhD Risoe National · Prospects for electricity development · Investment requirements · Key challenges · Final remarks #12 and the transport burden in Tanzania. Source: Modi, 2004 #12;2. Energy and Human Development Access to electricity

244

Key ornamental innovations facilitate diversification in an avian radiation  

E-Print Network [OSTI]

Key ornamental innovations facilitate diversification in an avian radiation Rafael Maiaa,1 , Dustin novel ways of interacting with the en- vironment (key innovations) play a fundamental role in promoting evolution of orna- mental traits. Because selection can operate only on existing vari- ation, the tendency

Rubenstein, Dustin R.

245

Practical Key-Recovery for All Possible Parameters of SFLASH  

E-Print Network [OSTI]

function over a finite field. However, unlike RSA this power function is an easy-to-invert bijec- tion a new practical key-recovery attack on the SFLASH signature scheme. SFLASH is a derivative of the older from the public-key. The attack uses new crypt- analytic tools, most notably pencils of matrices

Fouque, Pierre-Alain

246

Offshore Wind Power Experiences, Potential and Key Issues for  

E-Print Network [OSTI]

Offshore Wind Power Experiences, Potential and Key Issues for Deployment Jørgen Lemming, Poul Erik-Erik Clausen Title: Offshore Wind Power Experiences, Potential and Key Issues for Deployment Division: VEA, SYS Risø-R-1673(EN) January 2008 Abstract: Wind power has been growing at spectacular rates. Today

247

Apparatus, system, and method for synchronizing a timer key  

DOE Patents [OSTI]

A timer key relating to monitoring a countdown time of a countdown routine of an electronic device is disclosed. The timer key comprises a processor configured to respond to a countdown time associated with operation of the electronic device, a display operably coupled with the processor, and a housing configured to house at least the processor. The housing has an associated structure configured to engage with the electronic device to share the countdown time between the electronic device and the timer key. The processor is configured to begin a countdown routine based at least in part on the countdown time, wherein the countdown routine is at least substantially synchronized with a countdown routine of the electronic device when the timer key is removed from the electronic device. A system and method for synchronizing countdown routines of a timer key and an electronic device are also disclosed.

Condit, Reston A; Daniels, Michael A; Clemens, Gregory P; Tomberlin, Eric S; Johnson, Joel A

2014-04-22T23:59:59.000Z

248

Target  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security AdministrationcontrollerNanocrystallineForeign ObjectOUR8, 2013 FINAL MEETING SUMMARY7,TankLifetime

249

Targets  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassiveSubmittedStatus TomAboutManus Site-Inactive TWPCarbonTakeRVTape Mounts

250

Life Pure Fusion Target Designs: Status and Prospects  

SciTech Connect (OSTI)

Analysis and radiation-hydrodynamics simulations for expected high-gain fusion target performance on a demonstration 1-GWe Laser Inertial Fusion Energy (LIFE) power plant are presented. The required laser energy driver is 2.2 MJ at a 0.351-{mu}m wavelength, and a fusion target gain greater than 60 at a repetition rate of 16 Hz is the design goal for economic and commercial attractiveness. A scaling-law analysis is developed to benchmark the design parameter space for hohlraum-driven central hot-spot ignition. A suite of integrated hohlraum simulations is presented to test the modeling assumptions and provide a basis for near-term experimental resolution of the key physics uncertainties on the National Ignition Facility.

Amendt, P; Dunne, M; Ho, D; Lindl, J

2011-10-20T23:59:59.000Z

251

Automatic UAV Landing with Ground Target Maintained in the Field of View  

E-Print Network [OSTI]

Automatic UAV Landing with Ground Target Maintained in the Field of View Laurent Burlion and Henry de Plinval Abstract In this paper, a key feature for UAV visual servoing in automatic land- ing. First, a control law for UAV automatic landing is proposed. Then, the output con- straint method

252

Radioactive target needs for nuclear reactor physics and nuclear astrophysics , G. Barreau1  

E-Print Network [OSTI]

Radioactive target needs for nuclear reactor physics and nuclear astrophysics B.Jurado1* , G Gradignan, France 2 IPN, CNRS/IN2P3, Univ. Paris-Sud, 91405 Orsay, France Abstract: Nuclear reaction cross sections of short-lived nuclei are key inputs for new generation nuclear reactor simulations and for models

Boyer, Edmond

253

Non-PGM Target Update  

Broader source: Energy.gov (indexed) [DOE]

at 0.80 V set for a measured activity target of 11 Acm 3 at 0.90 V, iR-corrected. (Equivalent to 300 Acm 3 at 0.80 V assuming 70 mVdec Tafel slope.) Consistent criteria...

254

IBMS BoneKEy. 2009 April;6(4):132-149 http://www.bonekey-ibms.org/cgi/content/full/ibmske;6/4/132  

E-Print Network [OSTI]

and osteoporosis, yet uniquely without targeting the resident fat or bone cell. IBMS BoneKEy. 2009 April;6(4):132-149. 2009 International Bone & Mineral Society Introduction Osteoporosis and obesity, two of the most billion dollars in annual health service costs. (1) Osteoporosis, a disease characterized by diminished

255

The HERMES Polarized Hydrogen Internal Gas Target  

E-Print Network [OSTI]

internal gas targets. The HERMES hydrogen target is an internal polarized gas target using the storage cell frame on the right. atomic hydrogen beam and focuses it into a storage cell. The storage cellThe HERMES Polarized Hydrogen Internal Gas Target J. Stewart for The HERMES Collaboration

256

Quantum mechanical approaches to in silico enzyme characterization and drug design  

SciTech Connect (OSTI)

The astonishing, exponentially increasing rates of genome sequencing has led to one of the most significant challenges for the biological and computational sciences in the 21st century: assigning the likely functions of the encoded proteins. Enzymes represent a particular challenge, and a critical one, because the universe of enzymes is likely to contain many novel functions that may be useful for synthetic biology, or as drug targets. Current approaches to protein annotation are largely based on bioinformatics. At the simplest level, this annotation involves transferring the annotations of characterized enzymes to related sequences. In practice, however, there is no simple, sequence based criterion for transferring annotations, and bioinformatics alone cannot propose new enzymatic functions. Structure-based computational methods have the potential to address these limitations, by identifying potential substrates of enzymes, as we and others have shown. One successful approach has used in silico 'docking' methods, more commonly applied in structure-based drug design, to identify possible metabolite substrates. A major limitation of this approach is that it only considers substrate binding, and does not directly assess the potential of the enzyme to catalyze a particular reaction using a particular substrate. That is, substrate binding affinity is necessary but not sufficient to assign function. A reaction profile is ultimately what is needed for a more complete quantitative description of function. To address this rather fundamental limitation, they propose to use quantum mechanical methods to explicitly compute transition state barriers that govern the rates of catalysis. Although quantum mechanical, and mixed quantum/classical (QM/MM), methods have been used extensively to investigate enzymatic reactions, the focus has been primarily on elucidating complex reaction mechanisms. Here, the key catalytic steps are known, and they use these methods quantify substrate specificity. That is, we bring the power of quantum mechanics to bear on the problem of annotating enzyme function, which is a novel approach. Although it has been clear to us at the Jacobson group for some time that enzyme specificity may be encoded in transition states, rather than simply substrate recognition, the main limitation has always been computational expense. Using a hierarchy of different methods, they can reduce the list of plausible substrates of an enzyme to a small number in most cases, but even identifying the transition states for a dozen plausible substrates requires significant computational effort, beyond what is practical using standard QM/MM methods. For this project, they have chosen two enzyme superfamilies which they have used as 'model systems' for functional assignment. The enolase superfamily is a large group of {alpha}-{beta} barrel enzymes with highly diverse substrates and chemical transformations. Despite decades of work, over a third of the superfamily remains unassigned, which means that the remaining cases are by definition difficult to assign. They have focused on acid sugar dehydratases, and have considerable expertise on the matter. They are also interested in the isoprenoid synthase superfamily, which is of central interest to the synthetic biology community, because these enzymes are used by nature to create complex rare natural products of medicinal value. the most notable example of this is the artemisinin, an antimalarial compound that is found in trace amounts in the wormwod root. From the standpoint of enzyme function assignment, these enzymes are intriguing because they use a small number of chemically simple substrates to generate, potentially, tens of thousands of different products. Hence, substrate binding specificity is only a small part of the challenge; the key is determining how the enzyme directs the carbocation chemistry to specific products. These more complex modeling approaches clearly require quantum mechanical methods.

Nilmeier, J P; Fattebert, J L; Jacobson, M P; Kalyanaraman, C

2012-01-17T23:59:59.000Z

257

Neuroimaging for drug addiction and related behaviors  

SciTech Connect (OSTI)

In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

2011-10-01T23:59:59.000Z

258

Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding  

E-Print Network [OSTI]

Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding energy component analysis that conveys information on the physicochemical forces driving the protein for a specific protein target if not in the general case. It is here that the free energy component analysis

Jayaram, Bhyravabotla

259

Frontiers in drug discovery Integrating chemistry and biology in the search for the next generation of therapeutics.  

E-Print Network [OSTI]

Frontiers in drug discovery Integrating chemistry and biology in the search for the next generation a target,generating a lead molecule,opti- mizing its properties and then proceeding to preclinical to creating the next generation of therapeutic agents. Basic advances at the interface of chemistry

Cai, Long

260

Rethinking Americas Illegal Drug Policy  

E-Print Network [OSTI]

treatment); health care costs (drug-related illnesses, injuries); reduced performance in school; reduced performance at workplace; poor parenting, child abuse;

Donohue III, John J.

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS  

E-Print Network [OSTI]

Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ...

Flynn, Colleen A.

2011-12-31T23:59:59.000Z

262

Reactive Support and Voltage Control Service: Key Issues and Challenges  

E-Print Network [OSTI]

reactive support and voltage control services. Keywords ­ Competitive Electricity Markets, Reactive PowerReactive Support and Voltage Control Service: Key Issues and Challenges George Gross^, Paolo Marannino° and Gianfranco Chicco* ^ Department of Electrical and Computer Engineering, University

Gross, George

263

Detailed Description of Key NIF Milestones for NNSA Description  

E-Print Network [OSTI]

1 Detailed Description of Key NIF Milestones for NNSA Short Description NIC EP Rev 4.0 Approved = Milestone Reporting Tool, which NNSA uses to support quarterly status reporting of NIC Level 1-2 milestones

264

Key Factors in Displacement Ventilation Systems for Better IAQ  

E-Print Network [OSTI]

This paper sets up a mathematical model of three-dimensional steady turbulence heat transfer in an air-conditioned room of multi-polluting heat sources. Numerical simulation helps identify key factors in displacement ventilation systems that affect...

Wang, X.; Chen, J.; Li, Y.; Wang, Z.

2006-01-01T23:59:59.000Z

265

NREL: News - NREL Scientists Find Key Function for Ferredoxins...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

614 NREL Scientists Find Key Function for Ferredoxins in Algae Hydrogen Production Two of six iron-rich proteins shown to have role in algae metabolism; discovery could lead to...

266

Daylight quantum key distribution over 1.6 km  

E-Print Network [OSTI]

Quantum key distribution (QKD) has been demonstrated over a point-to-point transmission distance brings QKD a step closer to surface-to-satellite and other long-distance applications.

Buttler, W T; Lamoreaux, S K; Morgan, G L; Nordholt, J E; Peterson, C G

2000-01-01T23:59:59.000Z

267

Building America Expert Meeting: Key Innovations for Adding Energy...  

Broader source: Energy.gov (indexed) [DOE]

This report describes an expert meeting hosted by the Building America research team NAHB Research Center, which was held on February 8, 2012, in Orlando, Florida. The topic, Key...

268

Families First: Keys to Successful Family Functioning Communication  

E-Print Network [OSTI]

Families First: Keys to Successful Family Functioning Communication Rick Peterson, Extension Specialist and Assistant Professor, Department of Human Development, Virginia Tech Stephen Green, Department of Human Development, Virginia Tech www.ext.vt.edu Produced by Communications and Marketing, College

Liskiewicz, Maciej

269

Self-referenced continuous-variable quantum key distribution  

E-Print Network [OSTI]

We introduce a new continuous-variable quantum key distribution (CV-QKD) protocol, self-referenced CV-QKD, that eliminates the need for transmission of a high-power local oscillator between the communicating parties. In this protocol, each signal pulse is accompanied by a reference pulse (or a pair of twin reference pulses), used to align Alice's and Bob's measurement bases. We present a proof-of-principle, fiber-based experimental demonstration of the protocol and quantify the expected secret key rates by expressing them in terms of experimental parameters. Our analysis of the secret key rate fully takes into account the inherent uncertainty associated with the quantum nature of the reference pulse(s) and quantifies the limit at which the theoretical key rate approaches that of the respective conventional protocol that requires local oscillator transmission. The self-referenced protocol greatly simplifies the hardware required for CV-QKD, especially for potential integrated photonics implementations of trans...

Soh, Daniel B S; Coles, Patrick J; Ltkenhaus, Norbert; Camacho, Ryan M; Urayama, Junji; Sarovar, Mohan

2015-01-01T23:59:59.000Z

270

Nano Lect 1 Questions and Keypoints Key Points  

E-Print Network [OSTI]

Nano Lect 1 ­ Questions and Keypoints Key Points 1. What is nano technology: a. Very small technology with device in the 1nm to 100nm lots of useful properties Questions 1. Define nanotechnology. Is an nano

Smy, Tom

271

Input from Key Stakeholders in the National Security Technology Incubator  

SciTech Connect (OSTI)

This report documents the input from key stakeholders of the National Security Technology Incubator (NSTI) in developing a new technology incubator and related programs for southern New Mexico. The technology incubator is being developed as part of the National Security Preparedness Project (NSPP), funded by a Department of Energy (DOE)/National Nuclear Security Administration (NNSA) grant. This report includes identification of key stakeholders as well as a description and analysis of their input for the development of an incubator.

None

2008-01-31T23:59:59.000Z

272

LIFE Target Fabrication Research Plan Sept 2008  

SciTech Connect (OSTI)

The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

2008-11-10T23:59:59.000Z

273

Novel polyoxazolines polymer drug delivery platform  

E-Print Network [OSTI]

performed with 4 different polymers in multi- drug resistant (MCF7/ADR) human adenocarcinoma cells, non-resistant (MCF7) human adenocarcinoma cells and Madin-Darby canine kidney (MDCK) cells. All polymers were found lines. 2. To investigate the effect of the addition of drugs to the polymers on cell toxicity, micelles

274

Pricing in the Market for Anticancer Drugs  

E-Print Network [OSTI]

In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab brand name Yervoyat $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

Howard, David H.

275

Chemical Innovation in Drug Dr Matthew Fuchter  

E-Print Network [OSTI]

Chemical Innovation in Drug Discovery Dr Matthew Fuchter Lecturer in Synthetic and Medicinal&D Spending and Output #12;Chemical Innovation Impact Discovery Development Basic research: years 0-3 Pre 3, File DRUG Chemical start point Hit to lead Preclinical Assessment Synthetic Chemistry Chemistry

276

The World of Youthful Drug Use  

E-Print Network [OSTI]

they meet the fact that the use of drugs is illegal and exposes them to arrest and criminal prosecution. It was obvious that such kinds of information could be secured: only from the youths who were themselves in the drug using world. We could not rely on a...

Blumer, Herbert; Sutter, Alan; Smith, Roger; Ahmed, Samir

2000-04-01T23:59:59.000Z

277

Cascaded target normal sheath acceleration  

SciTech Connect (OSTI)

A cascaded target normal sheath acceleration (TNSA) scheme is proposed to simultaneously increase energy and improve energy spread of a laser-produced mono-energetic proton beam. An optimum condition that uses the maximum sheath field to accelerate the center of the proton beam is theoretically found and verified by two-dimensional particle-in-cell simulations. An initial 10 MeV proton beam is accelerated to 21 MeV with energy spread decreased from 5% to 2% under the optimum condition during the process of the cascaded TNSA. The scheme opens a way to scale proton energy lineally with laser energy.

Wang, W. P.; Shen, B. F.; Zhang, X. M.; Wang, X. F.; Xu, J. C.; Zhao, X. Y.; Yu, Y. H.; Yi, L. Q.; Shi, Y.; Zhang, L. G.; Xu, T. J.; Xu, Z. Z. [State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)] [State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)

2013-11-15T23:59:59.000Z

278

Targets and processes for fabricating same  

DOE Patents [OSTI]

In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

Cowan, Thomas (Dresden, DE); Malekos, Steven (Reno, NV); Korgan, Grant (Reno, NV); Adams, Jesse (Reno, NV); Sentoku, Yasuhiko (Reno, NV); Le Galloudec, Nathalie (Reno, NV); Fuchs, Julien (Paris, FR)

2012-07-24T23:59:59.000Z

279

Review of the Renewable Energy Target  

E-Print Network [OSTI]

Review of the Renewable Energy Target Response to Expert Panel's Call for Submissions Paper #12;NSW Government Submission to the Review of the Renewable Energy Target, May 2014 2/20 Contents EXECUTIVE SUMMARY........................................................................................................................... 3 RENEWABLE ENERGY IN NSW

Peters, Richard

280

Qualified Target Industry Tax Refund (Florida)  

Broader source: Energy.gov [DOE]

The Qualified Target Industry Tax Refund incentive is available for companies that create high wage jobs in targeted high value-added industries. The incentive refunds up to $3,000 per new full...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Nanoparticles for targeting the infarcted heart  

E-Print Network [OSTI]

We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in ...

Dvir, Tal

282

Quantum-Secure Authentication with a Classical Key  

E-Print Network [OSTI]

Authentication provides the trust people need to engage in transactions. The advent of physical keys that are impossible to copy promises to revolutionize this field. Up to now, such keys have been verified by classical challenge-response protocols. Such protocols are in general susceptible to emulation attacks. Here we demonstrate Quantum-Secure Authentication ("QSA") of an unclonable classical physical key in a way that is inherently secure by virtue of quantum-physical principles. Our quantum-secure authentication operates in the limit of a large number of channels, represented by the more than thousand degrees of freedom of an optical wavefront shaped with a spatial light modulator. This allows us to reach quantum security with weak coherent pulses of light containing dozens of photons, too few for an adversary to determine their complex spatial shapes, thereby rigorously preventing emulation.

Sebastianus A. Goorden; Marcel Horstmann; Allard P. Mosk; Boris kori?; Pepijn W. H. Pinkse

2014-06-03T23:59:59.000Z

283

Field Test of Measurement-Device-Independent Quantum Key Distribution  

E-Print Network [OSTI]

A main type of obstacles of practical applications of quantum key distribution (QKD) network is various attacks on detection. Measurement-device-independent QKD (MDIQKD) protocol is immune to all these attacks and thus a strong candidate for network security. Recently, several proof-of-principle demonstrations of MDIQKD have been performed. Although novel, those experiments are implemented in the laboratory with secure key rates less than 0.1 bps. Besides, they need manual calibration frequently to maintain the system performance. These aspects render these demonstrations far from practicability. Thus, justification is extremely crucial for practical deployment into the field environment. Here, by developing an automatic feedback MDIQKD system operated at a high clock rate, we perform a field test via deployed fiber network of 30 km total length, achieving a 16.9 bps secure key rate. The result lays the foundation for a global quantum network which can shield from all the detection-side attacks.

Yan-Lin Tang; Hua-Lei Yin; Si-Jing Chen; Yang Liu; Wei-Jun Zhang; Xiao Jiang; Lu Zhang; Jian Wang; Li-Xing You; Jian-Yu Guan; Dong-Xu Yang; Zhen Wang; Hao Liang; Zhen Zhang; Nan Zhou; Xiongfeng Ma; Teng-Yun Chen; Qiang Zhang; Jian-Wei Pan

2014-08-11T23:59:59.000Z

284

Security Proof of a Semi-Quantum Key Distribution Protocol  

E-Print Network [OSTI]

Semi-quantum key distribution protocols are designed to allow two users to establish a secure secret key when one of the two users is limited to performing certain "classical" operations. There have been several such protocols developed recently, however, due to their reliance on a two-way quantum communication channel (and thus, the attacker's opportunity to interact with the qubit twice), their security analysis is difficult and little is known concerning how secure they are compared to their fully quantum counterparts. In this paper we prove the unconditional security of a particular semi-quantum protocol. We derive an expression for the key rate of this protocol, in the asymptotic scenario, as a function of the quantum channel's noise. Finally, we will show that this semi-quantum protocol can tolerate a maximal noise level comparable to certain fully quantum protocols.

Walter O. Krawec

2014-11-30T23:59:59.000Z

285

anti-parkinsonian drug selegiline: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

286

E-Print Network 3.0 - adverse antiepileptic drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... Dosage Same or different? A drug in a different...

287

WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria  

E-Print Network [OSTI]

14 WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria Vincent Breton, Doman Kim ................................................................................ 354 14.2 Grid-Enabled Drug Discovery .................................................. 354 14.2.1 In Silico Drug Discovery: Requirements and Grid Added Value

Paris-Sud XI, Universit de

288

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network [OSTI]

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

289

Development of granular target for CADS  

E-Print Network [OSTI]

Subcritical core/blanket #12;· Solid target options, which consist of a solid material in the form of rods 5L/s Width of Lacuna 7cm #12;CW-316LSS The free surface in windowless target Water loop test-Parallel CFD (GPU) for Beam-Target-Coupled 15360 cores Test by the electron beam coupled with water Annular

McDonald, Kirk

290

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched5 IndustrialIsadore Perlman, 1960 The Ernest OrlandoJohn B.Jorge LuisKayeKey DatesKey

291

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched5 IndustrialIsadore Perlman, 1960 The Ernest OrlandoJohn B.Jorge LuisKayeKeyKey Dates

292

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched5 IndustrialIsadore Perlman, 1960 The Ernest OrlandoJohn B.Jorge LuisKayeKeyKey

293

Key Parameters Affecting DPF Performance Degradation and Impact on Lifetime  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensionalthe10 DOEWashington, DC 20585on253.16582104)Key Issues Key

294

Key Concepts in Project Development and Financing in Alaska  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel2007 | Department7JanuaryWASTE-TO-ENERGY:About » KeyKeyAbout

295

BUSCH CAMPUS KEY PICK UP INSTRUCTIONS: ALL STUDENTS: ONLY YOU CAN PICK UP YOUR KEY. You will be required to present photo  

E-Print Network [OSTI]

BUSCH CAMPUS KEY PICK UP INSTRUCTIONS: ALL STUDENTS: ONLY YOU CAN PICK UP YOUR KEY. You at the Housing and Residence Life Office, 581 Taylor Road, Busch Campus. If you are unable to pick up your key. _____________________________________________________________________________________ FIRST-YEAR STUDENTS MOVE-IN DAY KEY PICK UP BUSCH CAMPUS SATURDAY, AUGUST 28th 8:00 a.m. 2:00 p

296

Drugs and oil flow through the Eagle Ford Shale.  

E-Print Network [OSTI]

??This report is a work of original reporting which investigates the proliferation of drug use and drug trafficking in the Eagle Ford Shale, a region (more)

Marks, Michael Perry

2014-01-01T23:59:59.000Z

297

E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

298

antiepileptic drug development: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of drug design and development Bommarius Reading Jan 15 Tutorial Sherrill, David 28 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

299

Progress in chemical processing of LEU targets for {sup 99}Mo production -- 1997  

SciTech Connect (OSTI)

Presented here are recent experimental results of the continuing development activities associated with converting current processes for producing fission-product {sup 99}Mo from targets using high-enriched uranium (HEU) to low-enriched uranium (LEU). Studies were focused in four areas: (1) measuring the chemical behavior of iodine, rhodium, and silver in the LEU-modified Cintichem process, (2) performing experiments and calculations to assess the suitability of zinc fission barriers for LEU metal foil targets, (3) developing an actinide separations method for measuring alpha contamination of the purified {sup 99}Mo product, and (4) developing a cooperation with Sandia National Laboratories and Los Alamos National Laboratory that will lead to approval by the US Federal Drug Administration for production of {sup 99}Mo from LEU targets. Experimental results continue to show the technical feasibility of converting current HEU processes to LEU.

Vandegrift, G.F.; Conner, C.; Sedlet, J.; Wygmans, D.G. [Argonne National Lab., IL (United States); Wu, D. [Univ. of Illinois, Urbana, IL (United States); Iskander, F.; Landsberger, S. [Univ. of Texas, Austin, TX (United States)

1997-10-01T23:59:59.000Z

300

Therapeutic target for protozoal diseases  

DOE Patents [OSTI]

A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

2008-10-21T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Fabrication of boron sputter targets  

DOE Patents [OSTI]

A process for fabricating high density boron sputtering targets with sufficient mechanical strength to function reliably at typical magnetron sputtering power densities and at normal process parameters. The process involves the fabrication of a high density boron monolithe by hot isostatically compacting high purity (99.9%) boron powder, machining the boron monolithe into the final dimensions, and brazing the finished boron piece to a matching boron carbide (B.sub.4 C) piece, by placing aluminum foil there between and applying pressure and heat in a vacuum. An alternative is the application of aluminum metallization to the back of the boron monolithe by vacuum deposition. Also, a titanium based vacuum braze alloy can be used in place of the aluminum foil.

Makowiecki, Daniel M. (Livermore, CA); McKernan, Mark A. (Livermore, CA)

1995-01-01T23:59:59.000Z

302

Cedar Key Aquaculture Workshop Sulfide Concentrations in Sediments  

E-Print Network [OSTI]

Cedar Key Aquaculture Workshop Sulfide Concentrations in Sediments and Water: Influence on Hard;ObjectivesObjectives Examine sediment sulfide levels in the SuwanneeExamine sediment sulfide levels of sulfide on hard clam survivalsurvival #12;MethodsMethods SedimentSediment porewaterporewater samples

Florida, University of

303

Dictionaries Using Variable-Length Keys and Data, with Applications *  

E-Print Network [OSTI]

(Isil- logn, 1) + Itil) and Isil is the length of bit string si. We assume a word length w > log m. We present string Isil > 1, Itil > 1 for all bit-strings si and ti. Fox' fixed-length keys the dictionary problem

Blelloch, Guy E.

304

TICKS: KEY TO GENERA IN UNITED STATES Harry D. Pratt  

E-Print Network [OSTI]

·38 TICKS: KEY TO GENERA IN UNITED STATES Harry D. Pratt I Capitulum inferior; scutum absent. without definite sutural line. anus, indistinct, or absent. j ~ I lated .... ~ :. / ORNITHODOROS I ment Mouthparts much longer than ..~".'LJv--_, .0",,,,L } }_..., ---'~':r,.-.__.{ Mouthparts as long as basis

305

news and views A key issue for hydrogen storage materi-  

E-Print Network [OSTI]

news and views A key issue for hydrogen storage materi- als is that the hydrogenation and dehydro be possible to discover stable hydrogen hydrates with higher storage Hydrogen Posture Plan www.eere.energy.gov/hydrogenandfuelcells/pdfs/ hydrogen_posture_plan.pdf 7. Kuhs, W

Palumbi, Stephen

306

Using Key Performance Indicators to Manage Energy Costs  

E-Print Network [OSTI]

-effective to collect much more data than ever before, many energy managers find themselves drowning in the volume of data generated. Business information systems faced a similar challenge a decade ago, and it is now common practice to use Key Performance Indicators...

Van Gorp, J. C.

2005-01-01T23:59:59.000Z

307

Page 1 of 4 Creating and Submitting a Key Request  

E-Print Network [OSTI]

of employees. Enter search criteria in the search fields available and select the down red arrow to filter the terms. #12;Page 3 of 4 13. On the Key Request Form - Room List windowpane, select Add New. 14 use the Select Drawing button after entering the building and floor to display the floor plan

Howitt, Ivan

308

Cold Boot Key Recovery by Solving Polynomial Systems with Noise  

E-Print Network [OSTI]

Cold Boot Key Recovery by Solving Polynomial Systems with Noise Martin Albrecht and Carlos Cid 1 proposed in [9]; the technique was called Cold Boot attacks. When considering block ciphers Cold Boot attacks, was proposed in [9] and also provided an insight into the strength of a particular

Sheldon, Nathan D.

309

The Seven Keys to Success in Energy Management and Conservation  

E-Print Network [OSTI]

This paper is a summary of the seven key elements of the Deere & Company Energy Management and Conservation Program. These elements have been found to be essential for the ultimate success of any company-wide energy management program. The process...

Darby, D. F.

1984-01-01T23:59:59.000Z

310

SETTING INITIAL SECRET KEYS IN A MOBILE AD HOC NETWORK  

E-Print Network [OSTI]

SETTING INITIAL SECRET KEYS IN A MOBILE AD HOC NETWORK Murat Cihan1 and C¸etin Kaya Ko¸c2,3 1 I@eecs.oregonstate.edu Abstract. Mobile ad hoc networks require specialized authentication protocols due to the mobility of users and lack of always-available trusted servers. There are a variety of mobile ad hoc authentication protocols

311

Termites, elephants and fire are key drivers of tree mortality  

E-Print Network [OSTI]

mortality: 2 dominated by elephant damage, 2 by termite attack and 1 by fire. Wind and human activity wereTermites, elephants and fire are key drivers of tree mortality 5 plots suffered substantial tree not major causes of tree mortality. Sample sizes are too small to reasonably determine the most significant

312

Daylight quantum key distribution over 1.6 km  

E-Print Network [OSTI]

Quantum key distribution (QKD) has been demonstrated over a point-to-point $\\sim1.6$-km atmospheric optical path in full daylight. This record transmission distance brings QKD a step closer to surface-to-satellite and other long-distance applications.

W. T. Buttler; R. J. Hughes; S. K. Lamoreaux; G. L. Morgan; J. E. Nordholt; C. G. Peterson

2000-01-25T23:59:59.000Z

313

Key words: STREAMLINE, yeast, scale up, automation, sanitization.  

E-Print Network [OSTI]

adsorption by defining a realistic process example at small scale and taking it all the way up to a fullyKey words: STREAMLINE, yeast, scale up, automation, sanitization. Abstract This application note was evaluated by performing a sanitization study in which the column and system were challenged with culture

Lebendiker, Mario

314

Highly Efficient Quantum Key Distribution Immune to All Detector Attacks  

E-Print Network [OSTI]

Vulnerabilities and imperfections of single-photon detectors have been shown to compromise security for quantum key distribution (QKD). The measurement-device-independent QKD (MDI-QKD) appears to be the most appealing solution to solve the issues. However, in practice one faces severe obstacles of having significantly lower key generation rate, difficult two photon interferences, and remote synchronization etc. In this letter, we propose a highly efficient and simple quantum key distribution scheme to remove all of these drawbacks. Our proposal can be implemented with only small modifications over the standard decoy BB84 system. Remarkably it enjoys both the advantages of high key generation rate (being almost two orders of magnitude higher than that based on conventional MDI-QKD) comparable to the normal decoy system, and security against any detector side channel attacks. Most favorably one can achieve complete Bell state measurements with resort to single photon interference, which reduces significantly experimental costs. Our approach enables utilization of high speed and efficient secure communication, particularly in real-life scenario of both metropolitan and intercity QKD network, with an attack free fashion from arbitrary detector side channels.

Wen-Fei Cao; Yi-Zheng Zhen; Yu-Lin Zheng; Zeng-Bing Chen; Nai-Le Liu; Kai Chen; Jian-Wei Pan

2014-10-10T23:59:59.000Z

315

Essentials of Energy Key concepts for the day  

E-Print Network [OSTI]

Essentials of Energy 4/14/05 Key concepts for the day Markets monopoly Substitution volatility Energy intensity Levelized costs externalities I. Market essentials Are there working energy markets · international geo-political issues Speculation Long lead times for development so supply is not very responsive

316

PEM FUEL CELL TECHNOLOGY Key Research Needs and Approaches  

E-Print Network [OSTI]

Developer University #12;8 FUEL CELL RESEARCH NEEDS MEA optimization should focus on new materials Pt (full1 PEM FUEL CELL TECHNOLOGY Key Research Needs and Approaches Tom Jarvi UTC Power South Windsor, CT 06074 23 January 2008 #12;2 UTC POWER MARKET FOCUS Transportation Fuel Cells On-Site Power Solutions #12

317

BERNAL and RESTREPO Key issues for decentralization in municipal  

E-Print Network [OSTI]

BERNAL and RESTREPO Key issues for decentralization in municipal wastewater treatment Diana Paola, the inadequate management and disposal of wastewater and the implementation of sophisticated treatment systems is the decentralisation in wastewater treatment. In this article, it is proposed an overview of the state of the art

Boyer, Edmond

318

Public-Key Locally-Decodable Codes Brett Hemenway  

E-Print Network [OSTI]

Semantically-Secure Public Key En- cryption (SS-PKE) and any Private Information Retrieval (PIR) protocol. Since Homomorphic encryption implies PIR, we also show a reduction from any Homomorphic encryption protocol to PKLDC. Applying our construction to the best known PIR protocol (that of Gentry and Ramzan), we

Ostrovsky, Rafail

319

In 2010 a group of key forestry players  

E-Print Network [OSTI]

Forestry Skills Action Plan #12;Summary #12;In 2010 a group of key forestry players came together to start a movement across the sector to upskill the current, and train the future, forestry workforce. #12;In May 2010 Forestry Commission England convened a small cross- sector task and finish group

320

The U.S. ISO Key Project on Quasars  

E-Print Network [OSTI]

Observations for the U.S. key project on quasars using ISO were completed in April when the satellite's cryogen supply expired. This proceeding presents an update of the project, including information on the final sample, a discussion of some of the data reduction challenges and current efforts to meet them, plus a comparison of preliminary results with IRAS fluxes.

Eric Hooper; Belinda Wilkes; Kim McLeod; Jonathan McDowell; Martin Elvis; Matthew Malkan; Carol Lonsdale; Chris Impey

1998-09-22T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Architecture of the Secoqc Quantum Key Distribution network  

E-Print Network [OSTI]

The European projet Secoqc (Secure Communication based on Quantum Cryptography) aims at developing a global network for unconditionally secure key distribution. This paper specifies the requirements and presents the principles guiding the design of this network, and relevant to its architecture and protocols.

Mehrdad Dianati; Romain Alleaume

2006-10-25T23:59:59.000Z

322

The Design of a Group Key Agreement API Giuseppe Ateniese  

E-Print Network [OSTI]

and communication-independent API. The rest of this paper is organized as follows. We be- gin with the notationThe Design of a Group Key Agreement API Giuseppe Ateniese Computer Science Department Johns Hopkins describes a protocol suite and an API geared for securing collab- orative applications. The API is based

Kim, Dae-Shik

323

Cryptanalysis of two knapsack public-key cryptosystems  

E-Print Network [OSTI]

Han1 {jguobi,hanlidong}@sdu.edu.cn mengxm@sdfi.edu.cn 1 Key Laboratory of Cryptologic Technology is useless to the security of the cryptosystem. Because of the special super increasing structure, we can. We show that the permutation algorithm is useless to avoid the low-density attack and the density

324

Putting cancer in focusPathologists key to picking the  

E-Print Network [OSTI]

Putting cancer in focusPathologists key to picking the right path to a cure momentum IN THIS ISSUE without cancer. #12;EDITOR Heather Newman DESIGN Diana Duren DIRECTOR OF PUBLICATIONS Wayne Wood ASSOCIATE / Photo Researchers, Inc. EDITORIAL OFFICE Vanderbilt-Ingram Cancer Center 691 Preston Building Nashville

Eichman, Brandt F.

325

Efficient Algorithms for Implementing Elliptic Curve PublicKey Schemes  

E-Print Network [OSTI]

Efficient Algorithms for Implementing Elliptic Curve Public­Key Schemes by Dan Beauregard A Thesis Cyganski Thesis Advisor Thesis Committee Dr. Stanley Selkow Dr. John Orr Thesis Committee Department Head #12; Preface This thesis describes the research which I conducted while completing my graduate work

326

Key issues of FED/INTOR impurity control system  

SciTech Connect (OSTI)

A key part of the FED/INTOR activity over the past year has focused on examining the critical issues and developing credible physics and engineering solutions for the impurity control system. The primary emphasis of the work was on the edge-region physics, plasma-wall interaction, materials, engineering and magnetic considerations of the poloidal divertor and pump limiter.

Abdou, M.A.

1982-10-01T23:59:59.000Z

327

The Key Coal Producers ONLINE SUPPORTING MATERIALS to  

E-Print Network [OSTI]

The Key Coal Producers ONLINE SUPPORTING MATERIALS to A Global Coal Production Forecast with Multi's most important coal-producing area is North-Central China. The provinces of Inner Mongolia, Ningxia, Shaanxi and Shanxi together accounted for 83 percent of China's proven coal reserves in 2000, and Shanxi

Patzek, Tadeusz W.

328

Ignition of deuterium-trtium fuel targets  

DOE Patents [OSTI]

A method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom.

Musinski, Donald L. (Saline, MI); Mruzek, Michael T. (Britton, MI)

1991-01-01T23:59:59.000Z

329

Ignition of deuterium-tritium fuel targets  

DOE Patents [OSTI]

Disclosed is a method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom. 5 figures.

Musinski, D.L.; Mruzek, M.T.

1991-08-27T23:59:59.000Z

330

Thin-thick hydrogen target for nuclear physics  

SciTech Connect (OSTI)

In spectroscopic studies of unstable nuclei, hydrogen targets are of key importance. The CHyMENE Project aims to provide to the nuclear physics community a thin and pure solid windowless hydrogen or deuterium target. CHyMENE project must respond to this request for the production of solid Hydrogen. The solid hydrogen target is produced in a continuous flow (1 cm/s) by an extrusion technique (developed with the PELIN laboratory) in a vacuum chamber. The shape of the target is determined by the design of the nozzle at the extrusion process. For the purpose, the choice is a rectangular shape with a width of 10 mm and a thickness in the range of 30-50 microns necessary for the physics objectives. The cryostat is equipped with a GM Cryocooler with sufficient power for the solidification of the hydrogen in the lower portion of the extruder. In the higher part of the cryostat, the hydrogen gas is first liquefied and partially solidified. It is then compressed at 100 bars in the cooled extruder before expulsion of the film through the nozzle at the center of the reaction vacuum chamber. After the previous step, the solid hydrogen ribbon falls by gravity into a dedicated chamber where it sublimes and the gas is pumped and evacuated in a exhaust line. This paper deals with the design of the cryostat with its equipment, with the sizing of the thermal bridge (Aluminum and copper), with the results regarding the contact resistance as well as with the vacuum computations of the reaction and recovery hydrogen gas chambers.

Gheller, J.-M.; Juster, F.-P.; Authelet, G. [CEA Saclay, Irfu/SACM, F-91191 Gif-Sur-Yvette cedex (France); Vinyar, I. [PELIN Limited Liability Company 27 A, Gzhatskaya Str, office 103 St. Petersbourg 195220 (Russian Federation); Relland, J. [CEA Saclay, Irfu/SIS, F-91191 Gif-Sur-Yvette cedex (France); Commeaux, C. [Institut de Physique Nuclaire, campus Universitaire-Bat 103, 91406 Orsay cedex (France)

2014-01-29T23:59:59.000Z

331

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile  

SciTech Connect (OSTI)

The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licenced as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Na{sub v}1.5 sodium and Ca{sub v}1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (? 10 ?M) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. - Highlights: We study effects of anti-addiction drug ibogaine on ionic currents in cardiomyocytes. We assess the cardiac ion channel profile of ibogaine. Ibogaine inhibits hERG potassium, sodium and calcium channels. Ibogaines effects on ion channels are a potential source of cardiac arrhythmias. 18-Methoxycoronaridine has a lower affinity for cardiac ion channels than ibogaine.

Koenig, Xaver; Kovar, Michael; Rubi, Lena; Mike, Agnes K.; Lukacs, Peter; Gawali, Vaibhavkumar S.; Todt, Hannes [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Hilber, Karlheinz, E-mail: karlheinz.hilber@meduniwien.ac.at [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Sandtner, Walter [Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna (Austria)

2013-12-01T23:59:59.000Z

332

Experimental Target Injection and Tracking System  

SciTech Connect (OSTI)

Targets must be injected into an IFE power plant with an accuracy of and plusmn; 5 mm at a rate of approximately 5 to 10 each second. Targets must be tracked very accurately to allow driver beams to be aligned with defined points on the targets with accuracy {+-}200{mu}m for indirect drive and {+-}20{mu}m for direct drive. An experimental target injection and tracking system has been designed and is being constructed at General Atomics to investigate injection and tracking of both direct drive and indirect drive targets. The design is modular to allow testing of alternate target acceleration and tracking methods. The injector system will be used as a tool for testing the survivability of various target designs and provide feed back to the target designers. This 30 m long system will be the centerpiece of a Facility for developing IFE target fabrication and injection technologies. A high-speed high-flow gas valve (designed and built by Oak Ridge National Laboratory) will provide helium propellant gas to the targets. To avoid target damage from excessive acceleration, an 8 m gun barrel is being built to achieve 400 m/s target speed while not exceeding 10,000 m/s{sup 2} acceleration. Direct-drive targets are protected in the barrel by sabots that are spring loaded to separate into two halves after acceleration. A sabot deflector directs the sabot halves away from the target injection path. Gas expansion chambers and orifices, keep propellant gas out of the target-tracking region. Targets will be optically tracked with laser beams and line scan cameras. High-speed computations will calculate target position in less than 2 ms based on the output from the line-scan cameras. Target position and arrival time to a plane in the reaction chamber center will be predicted in real-time based on early target position measurements. The system design, construction progress, and early testing results will be presented.

Petzoldt, R.W. [General Atomics (United States); Alexander, N.B. [General Atomics (United States); Drake, T.J. [General Atomics (United States); Goodin, D.T. [General Atomics (United States); Stemke, R.W. [General Atomics (United States); Jonestrask, K

2003-07-15T23:59:59.000Z

333

Intradermal needle-free powdered drug injection  

E-Print Network [OSTI]

This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

Liu, John (John Hsiao-Yung)

2012-01-01T23:59:59.000Z

334

Alcohol and Other Drugs Education and Prevention  

E-Print Network [OSTI]

Free Workplace Policy. 2.0 POLICY STATEMENT In compliance with the federal government's Drug Free, because of Mines' status as a federal contractor and grant recipient and because marijuana use is still

335

Transdermal drug delivery by localized intervention  

E-Print Network [OSTI]

Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

Weaver, James C.

336

Computational model of local intravascular drug delivery  

E-Print Network [OSTI]

Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

Balakrishnan, Brinda

2007-01-01T23:59:59.000Z

337

Key-Insulated Signcryption (Science and Technology on Communication Security Laboratory,  

E-Print Network [OSTI]

Key-Insulated Signcryption Jia Fan 1 (Science and Technology on Communication Security Laboratory addresses the issue of key exposure by proposing a key-insulated signcryption technique. We define a security model for key-insulated signcryption and prove that the key- insulated signcryption technique

Zheng, Yuliang

338

Explanations of FreedomCAR/DOE Hydrogen Storage Technical Targets...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Explanations of FreedomCARDOE Hydrogen Storage Technical Targets Explanations of FreedomCARDOE Hydrogen Storage Technical Targets Summary of FreedomCAR Targets and Basis for...

339

The study of downstream targets and other characteristics of NTT  

E-Print Network [OSTI]

SAN DIEGO The Study of Downstream Targets and OtherOF THE THESIS The Study of Downstream Targets and Othera number of putative downstream targets of NTT, including

Fung, Michelle W.

2009-01-01T23:59:59.000Z

340

Independent Oversight Targeted Review, Y-12 National Security...  

Office of Environmental Management (EM)

Targeted Review, Y-12 National Security Complex - February 2012 Independent Oversight Targeted Review, Y-12 National Security Complex - February 2012 February 2012 Targeted Review...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Independent Oversight Targeted Review, Oak Ridge National Laboratory...  

Office of Environmental Management (EM)

Targeted Review, Oak Ridge National Laboratory - April 2014 Independent Oversight Targeted Review, Oak Ridge National Laboratory - April 2014 April 2014 Targeted Review of...

342

Bacteria-targeting nanoparticles for managing infections  

E-Print Network [OSTI]

Bacterial infections continue to be a significant concern particularly in healthcare settings and in the developing world. Current challenges include the increasing spread of drug resistant (DR) organisms, the side effects ...

Radovic-Moreno, Aleksandar Filip

2013-01-01T23:59:59.000Z

343

POLYMER PROGRAM SEMINAR "Targeted polymeric nanoparticles  

E-Print Network [OSTI]

, IMS Room 20 A variety of organic and inorganic materials have been utilized to generate nanoparticles drugs for combination therapy. The surface engineering of these nanoparticles may yield them "stealth

Alpay, S. Pamir

344

158 BrainResearch,359(1985) 158-165 Unfocused Laser Illumination Kills Dye-Targeted Mouse Neurons  

E-Print Network [OSTI]

158 BrainResearch,359(1985) 158-165 Elsevier BRE 11224 Unfocused Laser Illumination Kills Dye March 12th, 1985) Key words:laser-lesioning -- dye-targeting -- central nervous system-- in vitro by propidium iodide (PI), a fluorescent dye that leaks through damaged membranes and binds to nucleic acids

345

Tensor Target Polarization at TRIUMF  

SciTech Connect (OSTI)

The first measurements of tensor observables in $\\pi \\vec{d}$ scattering experiments were performed in the mid-80's at TRIUMF, and later at SIN/PSI. The full suite of tensor observables accessible in $\\pi \\vec{d}$ elastic scattering were measured: $T_{20}$, $T_{21}$, and $T_{22}$. The vector analyzing power $iT_{11}$ was also measured. These results led to a better understanding of the three-body theory used to describe this reaction. %Some measurements were also made in the absorption and breakup channels. A direct measurement of the target tensor polarization was also made independent of the usual NMR techniques by exploiting the (nearly) model-independent result for the tensor analyzing power at 90$^\\circ _{cm}$ in the $\\pi \\vec{d} \\rightarrow 2p$ reaction. This method was also used to check efforts to enhance the tensor polarization by RF burning of the NMR spectrum. A brief description of the methods developed to measure and analyze these experiments is provided.

Smith, G

2014-10-27T23:59:59.000Z

346

Public key Steganography Using Discrete Cross-Coupled Chaotic Maps  

E-Print Network [OSTI]

By cross-coupling two logistic maps a novel method is proposed for the public key steganography in JPEG image. Chaotic maps entail high complexity in the used algorithm for embedding secret data in a medium. In this paper, discrete cross- coupled chaotic maps are used to specifying the location of the different parts of the secret data in the image. Modifying JPEG format during compressing and decompressing, and also using public key enhanced difficulty of the algorithm. Simulation results show that in addition to excessive capacity, this method has high robustness and resistance against hackers and can be applicable in secret communication. Also the PSNR value is high compared to the other works.

Sodeif Ahadpour; Mahdiyeh Majidpour; Yaser Sadra

2012-11-01T23:59:59.000Z

347

I t=106sec3a 10 Energy key) 10'  

E-Print Network [OSTI]

. Optics for EUV, X-Ray, and Gamma-Ray Astronomy II, edited by Oberto Citterio, Stephen L. O'Dell, ProcRXTE HE& I t=106sec3a - AEIEH/2 a =10 - 10 Energy key) 10' IBIS NuSTAR Hard X-ray Optics Jason ESTAR will be the first satellite mission to employ focusing optics in the hard X-ray band (8- 80 keV). Its design

348

Economy key to 1992 U. S. oil, gas demand  

SciTech Connect (OSTI)

This paper provides a forecast US oil and gas markets and industry in 1992. An end to economic recession in the U.S. will boost petroleum demand modestly in 1992 after 2 years of decline. U.S. production will resume its slide after a fractional increase in 1991. Drilling in the U.S. will set a record low. Worldwide, the key questions are economic growth and export volumes from Iraq, Kuwait, and former Soviet republics.

Beck, R.J.

1992-01-27T23:59:59.000Z

349

City of Key West, Florida (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartmentAUDITOhio (UtilityHolyrood, Kansas (Utility Company)JohnsonKennett, MissouriKey

350

Moller Polarimetry with Atomic Hydrogen Targets  

SciTech Connect (OSTI)

A proposal to use polarized atomic hydrogen gas as the target for electron beam polarimetry based on the Moller scattering is described. Such a gas, stored in an ultra-cold magnetic trap, would provide a target of practically 100\\% polarized electrons. It is conceivable to reach a $\\sim$0.3\\% systematic accuracy of the beam polarimetry with such a target. Feasibility studies for the CEBAF electron beam have been performed.

Chudakov, Eugene [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Luppov, V. [University of Michigan Spin Physics Center, Ann Arbor, MI (United States)

2012-06-01T23:59:59.000Z

351

New Approach to Quantum Key Distribution Via Quantum Encryption  

E-Print Network [OSTI]

In this Paper, we investigate the security of Zhang, Li and Guo quantum key distribution via quantum encryption protocol [$\\text{Phys. Rev. A} \\textbf{64}, 24302 (2001)$] and show that it is not secure against some of Eve's attacks and with the probability one half she gets all of keys without being detected by the two parties. The main defect in this protocol is that there is an attack strategy by which Eve can change the previously shared Bell state between Alice and Bob to two Bell states among herself and Alice and Bob. Hence, we show that with probability $1/d$ its generalization to $d$-dimension systems is not secure and show that its extension to the case of more partners based on the reusable GHZ states is not secure and with probability one half Eve gets all of keys without being detected by the two parties. In what follows, we show how in going to higher dimensions those protocols can be repaired.

A. Fahmi

2006-04-25T23:59:59.000Z

352

DOE Program/Targets and Workshop Objectives  

Broader source: Energy.gov (indexed) [DOE]

Nancy Garland DOE Hydrogen Program Fuel Cell Operation at Sub- Freezing Temperatures DOE ProgramTargets and Workshop Objectives Sub-Freezing Temperature Effects on Fuel Cells...

353

Enterprise Assessments, Lessons Learned from Targeted Reviews...  

Energy Savers [EERE]

purpose of these targeted assessments was to evaluate the flowdown of occupational radiation protection program requirements into work planning, control, and execution...

354

E-Print Network 3.0 - access technologies key Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

electronic identifier (IdentiKey) including access and password requirements, account lockout... that are accessed using a university electronic identifier or IdentiKey. The...

355

A Comparison of Key PV Backsheet and Module Properties from Fielded...  

Broader source: Energy.gov (indexed) [DOE]

of Key PV Backsheet and Module Properties from Fielded Module Exposures and Accelerated Test Conditions A Comparison of Key PV Backsheet and Module Properties from Fielded...

356

Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance  

E-Print Network [OSTI]

period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

Clairambault, Jean

357

Rethinking drug policy: an integrity preserving compromise position  

E-Print Network [OSTI]

Definition of Drug Types?????????????...??.. 4 2 Definition of Drug Scheduling??????????????. 5 1 CHAPTER I INTRODUCTION TO STATUS QUO DRUG POLICY The issue of how to properly regulate the use of illegal.... Legalizers are those who would make legal all currently illegal drugs. The most 3 common middle stance is that of harm reduction, which is ?an alternative approach to drug policy and treatment that focuses on minimizing the adverse effects of both...

Crispino, Azzurra

2006-10-30T23:59:59.000Z

358

Design and Testing of a Prototype Spallation Neutron Source Rotating Target Assembly  

SciTech Connect (OSTI)

The mechanical aspects of an extended vertical shaft rotating target have been evaluated in a full-scale mockup test. A prototype assembly based on a conceptual target design for a 1 to 3-MW spallation facility was built and tested. Key elements of the drive/coupling assembly implemented in the prototype include high integrity dynamic face seals, commercially available bearings, realistic manufacturing tolerances, effective monitoring and controls, and fail-safe shutdown features. A representative target disk suspended on a 3.5 meter prototypical shaft was coupled with the drive to complete the mechanical tests. After1800 hours of operation the test program has confirmed the overall mechanical feasibility of the extended vertical shaft rotating target concept. Precision alignment of the suspended target disk; successful containment of the water and verification of operational stability over the full speed range of 30 to 60 rpm were primary indications the proposed mechanical design is valid for use in a high power target station.

Rennich, Mark J [ORNL; McManamy, Thomas J [ORNL; Graves, Van [Oak Ridge National Laboratory (ORNL); Garmendia, Amaia Zarraoa [IDOM Bilbao; Sorda, Fernando [ESS Bilbao

2010-01-01T23:59:59.000Z

359

Practical Training in Microalgae Utilization with Key Industry Engineering Group Key Industry Engineering Group s.r.o. has developed a biotechnology for the production of an animal  

E-Print Network [OSTI]

Practical Training in Microalgae Utilization with Key Industry Engineering Group Key Industry on a suspension of Planktochlorella microalgae. The product consists of a suspension of algae in the growing

360

Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB  

SciTech Connect (OSTI)

The emergence of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis (TB) is a serious global threat. Aminoglycoside antibiotics are used as a last resort to treat XDR-TB. Resistance to the aminoglycoside kanamycin is a hallmark of XDR-TB. Here, we reveal the function and structure of the mycobacterial protein Eis responsible for resistance to kanamycin in a significant fraction of kanamycin-resistant Mycobacterium tuberculosis clinical isolates. We demonstrate that Eis has an unprecedented ability to acetylate multiple amines of many aminoglycosides. Structural and mutagenesis studies of Eis indicate that its acetylation mechanism is enabled by a complex tripartite fold that includes two general control non-derepressible 5 (GCN5)-related N-acetyltransferase regions. An intricate negatively charged substrate-binding pocket of Eis is a potential target of new antitubercular drugs expected to overcome aminoglycoside resistance.

Chen, Wenjing; Biswas, Tapan; Porter, Vanessa R.; Tsodikov, Oleg V.; Garneau-Tsodikova, Sylvie (Michigan)

2011-09-06T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Multimodality Imaging with Silica-Based Targeted Nanoparticle Platforms  

SciTech Connect (OSTI)

Objectives: To synthesize and characterize a C-Dot silica-based nanoparticle containing 'clickable' groups for the subsequent attachment of targeting moieties (e.g., peptides) and multiple contrast agents (e.g., radionuclides with high specific activity) [1,2]. These new constructs will be tested in suitable tumor models in vitro and in vivo to ensure maintenance of target-specificity and high specific activity. Methods: Cy5 dye molecules are cross-linked to a silica precursor which is reacted to form a dye-rich core particle. This core is then encapsulated in a layer of pure silica to create the core-shell C-Dot (Figure 1) [2]. A 'click' chemistry approach has been used to functionalize the silica shell with radionuclides conferring high contrast and specific activity (e.g. 64Cu and 89Zr) and peptides for tumor targeting (e.g. cRGD and octreotate) [3]. Based on the selective Diels-Alder reaction between tetrazine and norbornene, the reaction is bioorthogonal, highyielding, rapid, and water-compatible. This radiolabeling approach has already been employed successfully with both short peptides (e.g. octreotate) and antibodies (e.g. trastuzumab) as model systems for the ultimate labeling of the nanoparticles [1]. Results: PEGylated C-Dots with a Cy5 core and labeled with tetrazine have been synthesized (d = 55 nm, zeta potential = -3 mV) reliably and reproducibly and have been shown to be stable under physiological conditions for up to 1 month. Characterization of the nanoparticles revealed that the immobilized Cy5 dye within the C-Dots exhibited fluorescence intensities over twice that of the fluorophore alone. The nanoparticles were successfully radiolabeled with Cu-64. Efforts toward the conjugation of targeting peptides (e.g. cRGD) are underway. In vitro stability, specificity, and uptake studies as well as in vivo imaging and biodistribution investigations will be presented. Conclusions: C-Dot silica-based nanoparticles offer a robust, versatile, and multi-functional platform to enhance in vivo detection sensitivity and non-invasively assay receptor expression/status of tumor cellular targets, including those of low abundance, using nuclear-NIR fluorescence imaging approaches [2]. Improvements in molecular diagnostics, refined by the availability of nanotechnology platforms, will be a key determinant in driving early-stage disease detection and prevention, ultimately leading to decreases in mortality.

Jason S. Lewis

2012-04-09T23:59:59.000Z

362

THE ROTATING TARGET FLOW TEST FACILITY  

E-Print Network [OSTI]

@idom.com) Fernando Sordo, ESS Bilbao Tom McManamy, ORNL/SNS #12;Status of the RTFT 4th HPTW of a RotaAng Target for ESS · In 2009 ESS Bilbao worked out a preliminary design for a rotaZng target for ESS. · Disc formed by un-clad tungsten bricks cooled

McDonald, Kirk

363

Target Options for a Neutrino Factory  

E-Print Network [OSTI]

shield WC 6. Target station engineering Target integration Remote maintenance Shielding 7. Beam dump 7a possible/preferable? · Can the beam size be increased (from 1.2 mm (rms) baseline)? #12;Heat loads ­ Heating and material damage Issues ­ Heat load from 4 MW pulsed proton beam · Total Heat load

McDonald, Kirk

364

Possible Target Options Michael A. Green  

E-Print Network [OSTI]

from low Z material. The target material should be ductile, with high thermal conductivity and should. These materials are strong and non- corrosive. The problem with niobium-titanium is its poor thermal conductivity, a desirable target material should have a medium to high Z. For low energy drivers the targe should be made

McDonald, Kirk

365

Delayed neutrons measurement at the MEGAPIE target  

E-Print Network [OSTI]

In the framework of the Neutronic and Nuclear Assessment Task Group of the MEGAPIE experiment we measured the delayed neutron (DN) flux at the top of the target. The measurement was proposed mainly for radioprotection purposes since the DN flux at the top of the target has been estimated to be of the same order of magnitude as the prompt neutron flux. Given the strong model-dependence of DN predictions, the measurement of DN contribution to the total neutron activity at the top of the target was thus desired. Moreover, this measurement is complementary to the DN experiments performed at PNPI (Gatchina) on solid lead and bismuth targets. The DN measurement at MEGAPIE was performed during the start-up phase of the target. In this paper we present a detailed description of the experimental setup and some preliminary results on decay spectra.

Stefano Panebianco; Pavel Bokov; Diane Dore; Xavier Ledoux; Alain Letourneau; Aurelien Prevost; Danas Ridikas

2007-05-25T23:59:59.000Z

366

Delayed neutrons measurement at the MEGAPIE target  

E-Print Network [OSTI]

In the framework of the Neutronic and Nuclear Assessment Task Group of the MEGAPIE experiment we measured the delayed neutron (DN) flux at the top of the target. The measurement was proposed mainly for radioprotection purposes since the DN flux at the top of the target has been estimated to be of the same order of magnitude as the prompt neutron flux. Given the strong model-dependence of DN predictions, the measurement of DN contribution to the total neutron activity at the top of the target was thus desired. Moreover, this measurement is complementary to the DN experiments performed at PNPI (Gatchina) on solid lead and bismuth targets. The DN measurement at MEGAPIE was performed during the start-up phase of the target. In this paper we present a detailed description of the experimental setup and some preliminary results on decay spectra.

Panebianco, Stefano; Dore, Diane; Ledoux, Xavier; Letourneau, Alain; Prevost, Aurelien; Ridikas, Danas

2007-01-01T23:59:59.000Z

367

The Jefferson Lab Frozen Spin Target  

SciTech Connect (OSTI)

A frozen spin polarized target, constructed at Jefferson Lab for use inside a large acceptance spectrometer, is described. The target has been utilized for photoproduction measurements with polarized tagged photons of both longitudinal and circular polarization. Protons in TEMPO-doped butanol were dynamically polarized to approximately 90% outside the spectrometer at 5 T and 200-300 mK. Photoproduction data were acquired with the target inside the spectrometer at a frozen-spin temperature of approximately 30 mK with the polarization maintained by a thin, superconducting coil installed inside the target cryostat. A 0.56 T solenoid was used for longitudinal target polarization and a 0.50 T dipole for transverse polarization. Spin relaxation times as high as 4000 hours were observed. We also report polarization results for deuterated propanediol doped with the trityl radical OX063.

Christopher Keith, James Brock, Christopher Carlin, Sara Comer, David Kashy, Josephine McAndrew, David Meekins, Eugene Pasyuk, Joshua Pierce, Mikell Seely

2012-08-01T23:59:59.000Z

368

Key results from SB8 simulant flowsheet studies  

SciTech Connect (OSTI)

Key technically reviewed results are presented here in support of the Defense Waste Processing Facility (DWPF) acceptance of Sludge Batch 8 (SB8). This report summarizes results from simulant flowsheet studies of the DWPF Chemical Process Cell (CPC). Results include: Hydrogen generation rate for the Sludge Receipt and Adjustment Tank (SRAT) and Slurry Mix Evaporator (SME) cycles of the CPC on a 6,000 gallon basis; Volume percent of nitrous oxide, N2O, produced during the SRAT cycle; Ammonium ion concentrations recovered from the SRAT and SME off-gas; and, Dried weight percent solids (insoluble, soluble, and total) measurements and density.

Koopman, D. C.

2013-04-26T23:59:59.000Z

369

Orthogonal-state-based protocols of quantum key agreement  

E-Print Network [OSTI]

Two orthogonal-state-based protocols of quantum key agreement (QKA) are proposed. The first protocol of QKA proposed here is designed for two-party QKA, whereas the second protocol is designed for multi-party QKA. Security of these orthogonal-state-based protocols arise from monogamy of entanglement. This is in contrast to the existing protocols of QKA where security arises from the use of non-orthogonal state (non-commutativity principle). Further, it is shown that all the quantum systems that are useful for implementation of quantum dialogue and most of the protocols of secure direct quantum communication can be modified to implement protocols of QKA.

Chitra Shukla; Nasir Alam; Anirban Pathak

2013-10-05T23:59:59.000Z

370

2014 CATEE: Collaboration is the Key- Public/Private Partnerships  

E-Print Network [OSTI]

, Texas Nov. 18-20 HGOC Education and Outreach ? District Meetings ? Peer Exchange ? Workshops ? Webinars ? One-on-One Trainings ? Newsletters ? Social media ESL-KT-14-11-24 CATEE 2014: Clean Air Through Efficiency Conference, Dallas, Texas Nov. 18...2014 CATEE Collaboration is the Key - Public/Private Partnerships November 19, 2014 Lisa Lin, Sustainability Manager, City of Houston ESL-KT-14-11-24 CATEE 2014: Clean Air Through Efficiency Conference, Dallas, Texas Nov. 18-20 City of Houston...

Lin, L.

2014-01-01T23:59:59.000Z

371

LEDSGP/Transportation Toolkit/Key Actions | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429 ThrottledInformation KumasiTools < LEDSGP‎ | DIA-Toolkit Jump<Key

372

NERSC Played Key Role in Nobel Laureate's Discovery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas Conchas recovery challengeMultiscaleLogos NERSC Logos NERSC logos arePlayed Key Role in Nobel

373

NNSA Administrator, Three Lab Directors Tour Key Weapons Facility |  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas Conchas recovery challengeMultiscaleLogos NERSCJeffreyKey ActionsThe NextAwards

374

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched5 IndustrialIsadore Perlman, 1960 The Ernest OrlandoJohn B.Jorge LuisKayeKey Dates

375

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched5 IndustrialIsadore Perlman, 1960 The Ernest OrlandoJohn B.Jorge LuisKayeKey

376

A Key Enzyme to the Potency of an Anticancer Agent  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered‰PNGExperience hands-onASTROPHYSICSHe β-Research andA Hollow-IonHybridA Key

377

A Key Enzyme to the Potency of an Anticancer Agent  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered‰PNGExperience hands-onASTROPHYSICSHe β-Research andA Hollow-IonHybridA KeyA

378

A Key Enzyme to the Potency of an Anticancer Agent  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered‰PNGExperience hands-onASTROPHYSICSHe β-Research andA Hollow-IonHybridA KeyAA

379

A Key Enzyme to the Potency of an Anticancer Agent  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered‰PNGExperience hands-onASTROPHYSICSHe β-Research andA Hollow-IonHybridA KeyAAA

380

Iron is the Key to Preserving Dinosaur Soft Tissue  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for andFuel-Efficient Engines |Iron is the Key to

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Iron is the Key to Preserving Dinosaur Soft Tissue  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for andFuel-Efficient Engines |Iron is the Key toIron is

382

Key Activities in Energy Efficiency | Department of Energy  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel2007 | Department7JanuaryWASTE-TO-ENERGY:About » Key Activities

383

GE Key Partner in Innovation Institutes | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun with Big Sky Learning Fun with Big SkyDIII-D Performance ToolsGlobalIs Key

384

Key Activities in Wind Energy | Department of Energy  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |EnergyonSupport0.pdf5 OPAM SEMIANNUAL REPORT TOJaredKansas City DataKen Salazar AboutKey

385

Key Activities of the Geothermal Technologies Office | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana.ProgramJulietipDepartmentJuneWhen IAjani Stewart was close toKeri FultonKey

386

Catalysis Center for Energy Innovation KEY ACCOMPLISHMENTS AND CORE CAPABILITIES  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation InInformationCenterResearchCASL Symposium:and Technical Information Catalogue ofKEY

387

Florida Keys El Coop Assn, Inc | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating Solar Power Basics (TheEtelligence (SmartHome Kyoung's pictureFlint ElectricKeys El

388

Cooperative target convergence using multiple agents  

SciTech Connect (OSTI)

This work considers the problem of causing multiple (100`s) autonomous mobile robots to converge to a target and provides a follow-the-leader approach to the problem. Each robot has only a limited-range sensor for sending the target and also larger but also limited-range robot-to-robot communication capability. Because of the small amount of information available to the robots, a practical approach to improve convergence to the target is to have a robot follow the robot with the best quality of information. Specifically, each robot emits a signal that informs in-range robots what its status is. A robot has a status value of 0 if it is itself in range of the target. A robot has a status of 1 if it is not in range of the target but is in communication range of a robot that is in range of the target. A robot has a status of 2 if it is not in range of the target but is within range of another robot that has status 1, and so on. Of all the mobile robots that any given robot is in range of, it follows the one with the best status. The emergent behavior is the ant-like trails of robots following each other toward the target. If the robot is not in range of another robot that is either in range of the target or following another robot, the robot will assign-1 to its quality-of-information, and will execute an exhaustive search. The exhaustive search will continue until it encounters either the target or another robot with a nonnegative quality-of-information. The quality of information approach was extended to the case where each robot only has two-bit signals informing it of distance to in-range robots.

Kwok, K.S.; Driessen, B.J.

1997-10-01T23:59:59.000Z

389

US Green Building Council Keys Branch Presents: Designing Mosquito Free Cisterns  

E-Print Network [OSTI]

Higgins, Sustainability Director - City of Key West Rainwater Harvesting from Roof Collection through

Watson, Craig A.

390

Towards Black-Box Accountable Authority IBE with Short Ciphertexts and Private Keys  

E-Print Network [OSTI]

Towards Black-Box Accountable Authority IBE with Short Ciphertexts and Private Keys Beno^it Libert1 in Identity-Based Encryption. In this model, if the Private Key Generator (PKG) maliciously re' public keys are public identifiers (e.g. email addresses) and the matching private keys are derived

Paris-Sud XI, Universit de

391

Encryption Key Search using Java-based ALiCE Grid  

E-Print Network [OSTI]

Encryption Key Search is a compute-intensive operation that consists of a brute-force search of a particular key in a given key space. Sequential execution time for a 56-bit encryption key search is approximately 200,000 ...

Virkar, Ameya

392

NAPS 2003, 35th North American Power Symposium, University of Missouri-Rolla in Rolla, Missouri, October 20-21, 2003. pp. 559-566. Abstract--Security of supply has been always a key factor  

E-Print Network [OSTI]

as a terrorist attack to some key power plants or transmission lines. Since September 11, 2001 the threat three kinds of threats over society: a) Attacks upon the power system. Here the target is the electricNAPS 2003, 35th North American Power Symposium, University of Missouri-Rolla in Rolla, Missouri

Catholic University of Chile (Universidad Catlica de Chile)

393

Micro-fabrication Techniques for Target Components  

SciTech Connect (OSTI)

Micro-fabrication techniques, derived from the semi-conductor industry, can be used to make a variety of useful mechanical components for targets. A selection of these components including supporting cooling arms for prototype cryogenic inertial confinement fusion targets, stepped and graded density targets for materials dynamics experiments are described. Micro-fabrication enables cost-effective, simultaneous fabrication of multiple high-precision components with complex geometries. Micro-fabrication techniques such as thin-film deposition, photo-lithographic patterning and etch processes normally used in the semi-conductor manufacture industry, can be exploited to make useful mechanical target components. Micro-fabrication processes have in recent years been used to create a number of micro-electro-mechanical systems (MEMS) components such as pressure sensors, accelerometers, ink jet printer heads, microfluidics platforms and the like. These techniques consist primarily of deposition of thin films of material, photo-lithographic patterning and etching processes performed sequentially to produce three dimensional structures using essentially planar processes. While the planar technology can be limiting in terms of the possible geometries of the final product, advantages of using these techniques include the ability to make multiple complex structures simultaneously and cost-effectively. Target components fabricated using these techniques include the supporting cooling arms for cryogenic prototype fusion ignition targets, stepped targets for equation-of-state experiments, and graded density reservoirs for material strength experiments.

Miles, R; Hamilton, J; Crawford, J; Ratti, S; Trevino, J; Graff, T; Stockton, C; Harvey, C

2008-06-10T23:59:59.000Z

394

Drug Innovation "Bridging Molecules and Diseases"  

E-Print Network [OSTI]

in the pharmaceutical industry. This focus area wishes to provide a knowledge and expertise platform, which platforms with the pharmaceutical industry are presently organized at three different levels: - Strategic, that allows high-level concerted drug research efforts in the molecular sciences, pharmaceutical sciences

Utrecht, Universiteit

395

Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer  

DOE Patents [OSTI]

Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.

Hu, Zhi (El Cerrito, CA); Kuo, Wen-Lin (San Ramon, CA); Neve, Richard M. (San Mateo, CA); Gray, Joe W. (San Francisco, CA)

2012-06-12T23:59:59.000Z

396

Self-assessing target with automatic feedback  

DOE Patents [OSTI]

A self assessing target with four quadrants and a method of use thereof. Each quadrant containing possible causes for why shots are going into that particular quadrant rather than the center mass of the target. Each possible cause is followed by a solution intended to help the marksman correct the problem causing the marksman to shoot in that particular area. In addition, the self assessing target contains possible causes for general shooting errors and solutions to the causes of the general shooting error. The automatic feedback with instant suggestions and corrections enables the shooter to improve their marksmanship.

Larkin, Stephen W.; Kramer, Robert L.

2004-03-02T23:59:59.000Z

397

Advances in target normal sheath acceleration theory  

SciTech Connect (OSTI)

A theoretical model of the Target Normal Sheath Acceleration (TNSA) process, able to go beyond the limits of available descriptions, is developed. It allows to achieve a more satisfactory interpretation of TNSA. The theory, also supported by two dimensional particle-in-cell simulations, elucidates the role played by the main laser and target parameters. Comparison between model predictions and experimental data related to the target thickness dependence of the maximum ion energy is discussed, showing satisfactory agreement. The model can be used as a simple but effective tool to guide the design of future experiments.

Passoni, M.; Sgattoni, A. [Dipartimento di Energia, Politecnico di Milano, and Sezione di Milano INFN, Milan (Italy)] [Dipartimento di Energia, Politecnico di Milano, and Sezione di Milano INFN, Milan (Italy); Perego, C. [Dipartimento di Fisica, Universit di Milano-Bicocca, Milan (Italy)] [Dipartimento di Fisica, Universit di Milano-Bicocca, Milan (Italy); Batani, D. [Universit Bordeaux, CNRS, CEA, CELIA (Centre Lasers Intenses et Applications), UMR 5107, F-33405 Talence (France) [Universit Bordeaux, CNRS, CEA, CELIA (Centre Lasers Intenses et Applications), UMR 5107, F-33405 Talence (France); Dipartimento di Energia, Politecnico di Milano, and Sezione di Milano INFN, Milan (Italy)

2013-06-15T23:59:59.000Z

398

ESO Imaging Survey: Finding Targets for VLT  

E-Print Network [OSTI]

Data from the wide-angle, moderately deep ESO Imaging Survey have been used to produce target lists for the first year of the VLT. About 250 candidate clusters of galaxies have been identified from the I-band images covering $\\sim$ 17 square degrees. In addition, using the multicolor data available over an area of 1.3 square degrees over 300 potentially interesting point-sources have been selected. The color-selected targets include low-mass stars/brown dwarfs, white-dwarfs and quasars. Images, object catalogs and derived target lists are available from the world-wide web (http://www.eso.org/eis)

L. N. da Costa

1998-09-16T23:59:59.000Z

399

Key Response Planning Factors for the Aftermath of Nuclear Terrorism  

SciTech Connect (OSTI)

Despite hundreds of above-ground nuclear tests and data gathered from Hiroshima and Nagasaki, the effects of a ground-level, low-yield nuclear detonation in a modern urban environment are still the subject of considerable scientific debate. Extensive review of nuclear weapon effects studies and discussions with nuclear weapon effects experts from various federal agencies, national laboratories, and technical organizations have identified key issues and bounded some of the unknowns required to support response planning for a low-yield, ground-level nuclear detonation in a modern U.S. city. This study, which is focused primarily upon the hazards posed by radioactive fallout, used detailed fallout predictions from the advanced suite of three-dimensional (3-D) meteorology and plume/fallout models developed at Lawrence Livermore National Laboratory (LLNL), including extensive global Key Response Planning Factors for the Aftermath of Nuclear Terrorism geographical and real-time meteorological databases to support model calculations. This 3-D modeling system provides detailed simulations that account for complex meteorology and terrain effects. The results of initial modeling and analysis were presented to federal, state, and local working groups to obtain critical, broad-based review and feedback on strategy and messaging. This effort involved a diverse set of communities, including New York City, National Capitol Regions, Charlotte, Houston, Portland, and Los Angeles. The largest potential for reducing casualties during the post-detonation response phase comes from reducing exposure to fallout radiation. This can be accomplished through early, adequate sheltering followed by informed, delayed evacuation.B The response challenges to a nuclear detonation must be solved through multiple approaches of public education, planning, and rapid response actions. Because the successful response will require extensive coordination of a large number of organizations, supplemented by appropriate responses by local responders and the general population within the hazard zones, regional planning is essential to success. The remainder of this Executive Summary provides summary guidance for response planning in three areas: (1) Public Protection Strategy details the importance of early, adequate shelter followed by informed evacuation. (2) Responder Priorities identify how to protect response personnel, perform regional situational assessment, and support public safety. (3) Key Planning Considerations refute common myths and provide important information on planning how to respond in the aftermath of nuclear terrorism.

Buddemeier, B R; Dillon, M B

2009-01-21T23:59:59.000Z

400

Webinar: Targeted Algal Biofuels and Bioproducts FOA  

Broader source: Energy.gov [DOE]

The Energy Departments Bioenergy Technologies Office will present a live informational webcast on the Targeted Algal Biomass and Bioproducts Funding Opportunity (DE-FOA-0001162) on October 8, 2014...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Beam Pulse Structure and Targets Roger Bennett  

E-Print Network [OSTI]

in a target. The shock wave travels through matter at the speed of sound, where E is Young's modulus of elasticity and is the density. E s = #12;The time taken for the wave to travel from the outer surface

McDonald, Kirk

402

EMC effect: asymptotic freedom with nuclear targets  

SciTech Connect (OSTI)

General features of the EMC effect are discussed within the framework of quantum chromodynamics as expressed via the operator product expansion and asymptotic freedom. These techniques are reviewed with emphasis on the target dependence. 22 references.

West, G.B.

1984-01-01T23:59:59.000Z

403

Statistical Modeling of Single Target Cell Encapsulation  

E-Print Network [OSTI]

High throughput drop-on-demand systems for separation and encapsulation of individual target cells from heterogeneous mixtures of multiple cell types is an emerging method in biotechnology that has broad applications in ...

Moon, SangJun

404

Nanotechnology-mediated targeting of tumor angiogenesis  

E-Print Network [OSTI]

Abstract Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging strategy for the development of therapies targeting tumor-associated angiogenesis is to harness the potential of nanotechnology ...

Banerjee, Deboshri

405

Computing the apparent centroid of radar targets  

SciTech Connect (OSTI)

A high-frequency multibounce radar scattering code was used as a simulation platform for demonstrating an algorithm to compute the ARC of specific radar targets. To illustrate this simulation process, several targets models were used. Simulation results for a sphere model were used to determine the errors of approximation associated with the simulation; verifying the process. The severity of glint induced tracking errors was also illustrated using a model of an F-15 aircraft. It was shown, in a deterministic manner, that the ARC of a target can fall well outside its physical extent. Finally, the apparent radar centroid simulation based on a ray casting procedure is well suited for use on most massively parallel computing platforms and could lead to the development of a near real-time radar tracking simulation for applications such as endgame fuzing, survivability, and vulnerability analyses using specific radar targets and fuze algorithms.

Lee, C.E.

1996-12-31T23:59:59.000Z

406

Analysis of Climate Policy Targets under Uncertainty  

E-Print Network [OSTI]

Although policymaking in response to the climate change is essentially a challenge of risk management, most studies of the relation of emissions targets to desired climate outcomes are either deterministic or subject to a ...

Jacoby, Henry D.

407

Targeting cancer metabolism: a therapeutic window opens  

E-Print Network [OSTI]

Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

Vander Heiden, Matthew G.

408

SNS Target R&D Presented by  

E-Print Network [OSTI]

since been resolved ­ QA program would have to be very stringent for long lifetime Second target station implemented #12;11 Managed by UT-Battelle for the U.S. Department of Energy Spallation Neutron Source

McDonald, Kirk

409

Alignment strategies for drug product process development and manufacturing  

E-Print Network [OSTI]

The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the product-process interaction ...

Garvin, Christopher John

2012-01-01T23:59:59.000Z

410

Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs  

E-Print Network [OSTI]

Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

Stauber, Zachary Jason

2012-01-01T23:59:59.000Z

411

Research paper Drug diffusion and binding in ionizable interpenetrating networks  

E-Print Network [OSTI]

Research paper Drug diffusion and binding in ionizable interpenetrating networks from poly) (PVA), poly(acrylic acid) (PAA), and their interpenetrating networks (IPNs) were prepared using by measuring their equilibrium polymer volume fraction, equilibrium swelling ratio, and mesh size. Drug

Peppas, Nicholas A.

412

High throughput optical sensor arrays for drug screening  

E-Print Network [OSTI]

In the world of drug discovery, high throughput whole cell assays are a critical step in discovering therapeutically relevant drug compounds [1]. This report details the development of several novel sensor systems capable ...

Harjes, Daniel I

2006-01-01T23:59:59.000Z

413

Luminal flow amplifies stent-based drug deposition in arterial  

E-Print Network [OSTI]

Background: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely ...

Levine, Evan G.

414

Specific and general binding in arterial drug delivery  

E-Print Network [OSTI]

Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

Levin, Andrew D. (Andrew David), 1976-

2005-01-01T23:59:59.000Z

415

Attitudes toward the integration of smoking cessation treatment into drug abuse clinics.  

E-Print Network [OSTI]

Direct Care Workforce in the National Drug Abuse Treatmentdependence treatment into drug abuse care reduces thesecare settings but not yet in independent drug abuse treatment

2007-01-01T23:59:59.000Z

416

E-Print Network 3.0 - arv drug patents Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... country Generic name Non proprietary, same...

417

E-Print Network 3.0 - anticancer drug levels Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Chemistry 7 Oxford University Press 2005 1 Discovering drug interactions: a text-mining and reasoning ap- Summary: is responsible for metabol- ism of drug B. Such drug...

418

E-Print Network 3.0 - anticancer drug topotecan Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

419

E-Print Network 3.0 - anticancer drug combretastatin-a2 Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

420

E-Print Network 3.0 - anticancer drug oracin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

E-Print Network 3.0 - anticancer drugs mitoxantrone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

422

E-Print Network 3.0 - anticancer drug roscovitine Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

423

E-Print Network 3.0 - anticancer drug mitoxantrone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

424

E-Print Network 3.0 - antiretroviral drugs arvs Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(ARV) drugs except... . Assessment of a pilot antiretroviral drug therapy programme in Uganda: patients' response, survival, and drug... 1 Early loss to program in HIV-infected ......

425

E-Print Network 3.0 - analyzing drug combination Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

, Saadat Anwar2 , Shanshan Liang2... : Identifying drug-drug interactions is a critical process in drug administration and ... Source: Baral, Chitta - Department of Computer...

426

E-Print Network 3.0 - antiviral drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Opin Emerg Drugs . Author manuscript Emerging drugs for hepatitis B Summary: and to design new trials of combination therapy to delay drug resistance. In the future, antiviral...

427

Securing AODV for MANETs using Message Digest with Secret Key  

E-Print Network [OSTI]

Due to lack of the infrastructure, open peer-to-peer architecture, shared wireless medium, limited resource constraints and highly dynamic topology, MANETs (Mobile Adhoc Networks) are frequently established in insecure environments, which make them more vulnerable to attacks. These attacks are initiated by sharing malicious nodes against different services of network. The binding force in these networks is routing protocol, which is a common target of malicious nodes. MANETs routing protocols are being developed without having security in mind. Ad-hoc On-Demand Distance Vector (AODV) is one such widely used routing protocol that is at present undergo extensive research and development. AODV is based on distance vector routing, but here the updates are shared not on a periodic basis but on an as per demand basis. The control packets contain a hop-count and sequence number field which recognizes the freshness of routing. These fields are editable, so it creates a possible susceptibility that is frequently abuse...

Lakhtaria, Mr Kamaljit; Prajapati, Mr Satish G; Jani, N N

2010-01-01T23:59:59.000Z

428

PET IMAGING STUDIES IN DRUG ABUSE RESEARCH.  

SciTech Connect (OSTI)

There is overwhelming evidence that addiction is a disease of the brain (Leshner, 1997). Yet public perception that addiction is a reflection of moral weakness or a lack of willpower persists. The insidious consequence of this perception is that we lose sight of the fact that there are enormous medical consequences of addiction including the fact that a large fraction of the total deaths from cancer and heart disease are caused by smoking addiction. Ironically the medical school that educates physicians in addiction medicine and the cancer hospital that has a smoking cessation clinic are vanishingly rare and efforts at harm reduction are frequently met with a public indignation. Meanwhile the number of people addicted to substances is enormous and increasing particularly the addictions to cigarettes and alcohol. It is particularly tragic that addiction usually begins in adolescence and becomes a chronic relapsing problem and there are basically no completely effective treatments. Clearly we need to understand how drugs of abuse affect the brain and we need to be creative in using this information to develop effective treatments. Imaging technologies have played a major role in the conceptualization of addiction as a disease of the brain (Fowler et al., 1998a; Fowler et al., 1999a). New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology and medicine. This topic cuts across the medical specialties of neurology, psychiatry, cancer and heart disease because of the high medical, social and economic toll that drugs of abuse, including and especially the legal drugs, cigarettes and alcohol, take on society. In this chapter we will begin by highlighting the important role that chemistry has played in making it possible to quantitatively image the movement of drugs as well as their effects on the human brain. This will be followed by highlights of PET studies of the acute effects of the psychostimulant drugs cocaine and methylphenidate (ritalin) and studies of the chronic effects of cocaine and of tobacco smoke on the human brain. This chapter concludes with the description of a study which uses brain imaging coupled with a specific pharmacological challenge to address the age-old question of why some people who experiment with drugs become addicted while others do not.

Fowler, J.S.; Volkow, N.D.; Ding, Y.S.; Logan, J.; Wang, G.J.

2001-01-29T23:59:59.000Z

429

Proper Usage of Drugs and Chemicals in Food Animals  

E-Print Network [OSTI]

of omission or commission, violative residues in livestock and poultry (by irresponsible and illegal distribution and use of drugs) violates state and federal laws. When FSIS inspectors detect violative drug residues in food products derived from ani- mals... quality ani- mal food products. Extra-label distribution, prescription and use of veterinary drugs in food producing animals are reg- ulated by FDA. The FDA policy requires all extra- label drug usage to be under the control of a licensed veterinarian...

Faries Jr., Floron C.

2002-02-15T23:59:59.000Z

430

Model-Based Dependability Analysis of Programmable Drug Infusion Pumps  

E-Print Network [OSTI]

Model-Based Dependability Analysis of Programmable Drug Infusion Pumps Sriram Sankaranarayanan.lastname@colorado.edu Abstract. Infusion pumps are commonly used in home/hospital care to inject drugs into a patient a case-study involving an infusion pump used to manage pain through the infusion of analgesic drugs

Sankaranarayanan, Sriram

431

Drug-Free Federal Workplace Testing Implementation Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations that facilitate the maintenance of a drug-free Federal workplace through the establishment of programs to test for the use of illegal drugs. Chg 1, dated 8-21-92

1988-07-29T23:59:59.000Z

432

Creation of mixed beam from alloy target and couple of pure targets with laser  

SciTech Connect (OSTI)

To create mixed species ion beam with laser pulses, we investigated charge state distributions of plasma formed from both Al-Fe alloy targets and pure Al and Fe targets placed close together. With two targets, we observed that the two kinds of atoms were mixed when the interval of two laser pulses was large enough (40 ?s). On the other hand, when the interval was 0.0 ?s, we observed fewer Fe ions and they did not mix well with the Al ions. The two species were mixed well in the plasma from the alloy target. Furthermore, we observed that specific charge states of Fe ions increased. From the results, it was determined that we can use two pure targets to mix two species whose difference of the drift velocity is large. On the other hand, we must use an alloy target when the drift velocities of the species are close.

Ikeda, Shunsuke, E-mail: shunsuke.ikeda@riken.jp; Sekine, Megumi [Tokyo Institute of Technology, Yokohama, Kanagawa (Japan) [Tokyo Institute of Technology, Yokohama, Kanagawa (Japan); Riken, Wako, Saitama (Japan); Romanelli, Mark [Cornell University, Ithaca, New York 14850 (United States)] [Cornell University, Ithaca, New York 14850 (United States); Cinquegrani, David [University of Michigan, Ann Arbor, Michigan 48109 (United States)] [University of Michigan, Ann Arbor, Michigan 48109 (United States); Kumaki, Masafumi [Waseda University, Shinjuku, Tokyo (Japan)] [Waseda University, Shinjuku, Tokyo (Japan); Fuwa, Yasuhiro [Kyoto University, Uji, Kyoto (Japan)] [Kyoto University, Uji, Kyoto (Japan); Munemoto, Naoya; Horioka, Kazuhiko [Tokyo Institute of Technology, Yokohama, Kanagawa (Japan)] [Tokyo Institute of Technology, Yokohama, Kanagawa (Japan); Kanesue, Takeshi; Okamura, Masahiro [Brookhaven National Laboratory, Upton, New York 11973 (United States)] [Brookhaven National Laboratory, Upton, New York 11973 (United States); Jin, Qianyu [Institute of Modern Physics, Lanzhou, Gansu (China)] [Institute of Modern Physics, Lanzhou, Gansu (China)

2014-02-15T23:59:59.000Z

433

From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement  

E-Print Network [OSTI]

reputation-2009-2). Carter, Jimmy. 1977. Drug Abuse Messagea presidential candidate in 1976, Jimmy Carter even adopted

Heddleston, Thomas Reed

2012-01-01T23:59:59.000Z

434

Decommissioning and PIE of the MEGAPIE spallation target  

SciTech Connect (OSTI)

A key experiment in the Accelerated Driven Systems roadmap, the MEGAwatt PIlot Experiment (MEGAPIE) (1 MW) was initiated in 1999 in order to design and build a liquid lead-bismuth spallation target, then to operate it into the Swiss spallation neutron facility SINQ at Paul Scherrer Institute. The target has been designed, manufactured, and tested during integral tests, before irradiation carried out end of 2006. During irradiation, neutron and thermo hydraulic measurements were performed allowing deep interpretation of the experiment and validation of the models used during design phase. The decommissioning, Post Irradiation Examinations and waste management phases were defined properly. The phases dedicated to cutting, sampling, cleaning, waste management, samples preparation and shipping to various laboratories were performed by PSI teams: all these phases constitute a huge work, which allows now to perform post-irradiation examination (PIE) of structural material, irradiated in relevant conditions. Preliminary results are presented in the paper, they concern chemical characterization. The following radio-nuclides have been identified by ?-spectrometry: {sup 60}Co, {sup 101}Rh, {sup 102}Rh, {sup 108m}Ag, {sup 110m}Ag, {sup 133}Ba, {sup 172}Hf/Lu, {sup 173}Lu, {sup 194}Hg/Au, {sup 195}Au, {sup 207}Bi. For some of these nuclides the activities can be easily evaluated from ?-spectrometry results ({sup 207}Bi, {sup 194}Hg/Au), while other nuclides can only be determined after chemical separations ({sup 108m}Ag, {sup 110m}Ag, {sup 195}Au, {sup 129}I, {sup 36}Cl and ?-emitting {sup 208-210}Po). The concentration of {sup 129}I is lower than expected. The chemical analysis already performed on spallation and corrosion products in the lead-bismuth eutectic (LBE) are very relevant for further applications of LBE as a spallation media and more generally as a coolant.

Latge, C.; Henry, J. [CEA-Cadarache, DEN-DTN, 13108 Saint-Paul-les-Durance (France); Wohlmuther, M.; Dai, Y.; Gavillet, D.; Hammer, B.; Heinitz, S.; Neuhausen, J.; Schumann, D.; Thomsen, K.; Tuerler, A.; Wagner, W. [PSI, Villigen (Switzerland); Gessi, A. [ENEA, Brasimone (Italy); Guertin, A. [CNRS, Subatech, Nantes (France); Konstantinovic, M. [SCK-CEN, Mol (Belgium); Lindau, R. [KIT, Karlsruhe (Germany); Maloy, S. [DOE-LANL, Los Alamos (United States); Saito, S. [JAEA, Tokai (Japan)

2013-07-01T23:59:59.000Z

435

The CNGS Target Station Presented by L.Bruno  

E-Print Network [OSTI]

sealed system filled with 0.5 bar of He. The tube has annular fins to enhance convective heat transfer enclosure Inlet target Inlet fixed shielding Outlet Beam #12;The target Assembly The CNGS Target Station as

McDonald, Kirk

436

Risk and Performance Technologies: Identifying the Keys to Successful Implementation  

SciTech Connect (OSTI)

The nuclear power industry has been utilizing risk and performance based technologies for over thirty years. Applications of these technologies have included risk assessment (e.g. Individual Plant Examinations), burden reduction (e.g. Risk-Informed Inservice Inspection, RI-ISI) and risk management (Maintenance Rule, 10CFR50.65). Over the last five to ten years the number of risk-informed (RI) burden reduction initiatives has increased. Unfortunately, the efficiencies of some of these applications have been questionable. This paper investigates those attributes necessary to support successful, cost-effective RI-applications. The premise to this paper is that by understanding the key attributes that support one successful application, insights can be gleaned that will streamline/coordinate future RI-applications. This paper is an extension to a paper presented at the Pressure Vessel and Piping (PVP-2001) Conference. In that paper, a number issues and opportunities were identified that needed to be assessed in order to support future (and efficient) RI-applications. It was noted in the paper that a proper understanding and resolution of these issues will facilitate implementation of risk and performance technology in the operation, maintenance and design disciplines. In addition, it will provide the foundation necessary to support regulatory review and approval. (authors)

McClain, Lynn [Niagara Mohawk (United States); Smith, Art [Entergy Operations (United States); O'Regan, Patrick [Electric Power Research Institute - EPRI, 3420 Hillview Avenue, Palo Alto, California 94304 (United States)

2002-07-01T23:59:59.000Z

437

Environmental labelling of green electricity with LCA key parameter models  

E-Print Network [OSTI]

Since the opening of European electricity markets, companies are launching green electricity products. In Switzerland the privately initiated eco-label naturemade star ensures the environmental and ecological quality of electricity from renewable energy sources on a local scale and from a life cycle perspective. For the life cycle perspective, a simplified and partly site-specific life cycle assessment (LCA) is applied using the Eco-indicator 99 (Hierachist perspective) impact assessment method. In a first step, detailed LCAs case studies are made for power plants and technologies that are candidates for the naturemade star label. They allow identifying technology-specific parameters that dominate the outcome of the LCA and for which data are available for the owner or operator of the power plant at issue. Based on this knowledge, key parameter models for photovoltaic, wind and hydroelectric power and electricity from biogas have been established on a spreadsheet-basis. With the help of the parameter models, operators of power plants can carry out the required LCA within a few hours. At the same time, they can check whether the plant fulfils the naturemade star threshold or not, which has been set to 50 % of the environmental impact of a gas combined cycle power plant. Within a few months since the introduction of the labelling scheme, companies successfully applied the parameter models on nearly 50 photovoltaic and on several hydroelectric power plants. LCA is, in combination with other tools, a useful method for the definition of standards for environmental labelling of green electricity.

unknown authors

438

Key Geomechanics Issues at the Waste Isolation Pilot Plant Geomechanics  

SciTech Connect (OSTI)

Mechanical and hydrological properties of rock salt provide excellent bases for geological isolation of hazardous materials. Regulatory compliance determinations for the Waste Isolation Pilot Plant (WIPP) stand as testament to the widely held conclusion that salt provides excellent isolation properties. The WIPP saga began in the 1950s when the U.S. National Academy of Sciences (NAS) recommended a salt vault as a promising solution to the national problem of nuclear waste disposal. For over 20 years, the Scientific basis for the NAS recommendation has been fortified by Sandia National Laboratories through a series of large scale field tests and laboratory investigations of salt properties. These scientific investigations helped develop a comprehensive understanding of salt's 4 reformational behavior over an applicable range of stresses and temperatures. Sophisticated constitutive modeling, validated through underground testing, provides the computational ability to model long-term behavior of repository configurations. In concert with advancement of the mechanical models, fluid flow measurements showed not only that the evaporite lithology was essentially impermeable but that the WIPP setting was hydrologically inactive. Favorable mechanical properties ensure isolation of materials placed in a salt geological setting. Key areas of the geomechanics investigations leading to the certification of WIPP are in situ experiments, laboratory tests, and shaft seal design.

HANSEN,FRANCIS D.

1999-09-01T23:59:59.000Z

439

Lowest Engine-Out Emissions as the Key to the Future of the Heavy...  

Broader source: Energy.gov (indexed) [DOE]

Lowest Engine-Out Emissions as the Key to the Future of the Heavy-Duty Diesel Engine: New Development Rersults Lowest Engine-Out Emissions as the Key to the Future of the...

440

Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery  

E-Print Network [OSTI]

Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

Seto, Jennifer Elizabeth

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Enterprise Assessments Targeted Review,Y-12 National Security...  

Office of Environmental Management (EM)

Y-12 National Security Complex - March 2015 Enterprise Assessments Targeted Review,Y-12 National Security Complex - March 2015 March 2015 Targeted Review of Work Planning and...

442

EV Everywhere Electric Drive Workshop: Preliminary Target-Setting...  

Broader source: Energy.gov (indexed) [DOE]

Electric Drive Workshop: Preliminary Target-Setting Framework EV Everywhere Electric Drive Workshop: Preliminary Target-Setting Framework Presentation given at the EV Everywhere...

443

Antibody-free, targeted mass-spectrometric approach for quantification...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in Antibody-free, targeted mass-spectrometric approach for...

444

Fluorescent Multiblock ?-Conjugated Polymer Nanoparticles for In Vivo Tumor Targeting  

E-Print Network [OSTI]

Highly fluorescent multiblock conjugated polymer nanoparticles with folic acid surface ligands are highly effective for bioimaging and in vivo tumor targeting. The targeted nanoparticles were preferentially localized in ...

Ahmed, Eilaf

445

ascl1 target genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for postgenomic analysis of mammalian gene function is gene targeting McConnell, Susan 2 Infrared lasermediated gene induction in targeted Chemistry Websites Summary: a heat shock...

446

abolishes gene targeting: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for postgenomic analysis of mammalian gene function is gene targeting McConnell, Susan 2 Infrared lasermediated gene induction in targeted Chemistry Websites Summary: a heat shock...

447

EPA-GHG Inventory Targeted Data Collection Strategies and Software...  

Open Energy Info (EERE)

EPA-GHG Inventory Targeted Data Collection Strategies and Software Tools (Redirected from US EPA GHG Inventory Targeted Data Collection Strategies and Software Tools) Jump to:...

448

Fixed target facility at the SSC  

SciTech Connect (OSTI)

The question of whether a facility for fixed target physics should be provided at the SSC must be answered before the final technical design of the SSC can be completed, particularly if the eventual form of extraction would influence the magnet design. To this end, an enthusiastic group of experimentalists, theoreticians and accelerator specialists have studied this point. The accelerator physics issues were addressed by a group led by E. Colton whose report is contained in these proceedings. The physics addressable by fixed target was considered by many of the Physics area working groups and in particular by the Structure Function Group. This report is the summary of the working group which considered various SSC fixed target experiments and determined which types of beams and detectors would be required. 13 references, 5 figures.

Loken, S.C.; Morfin, J.G.

1985-01-01T23:59:59.000Z

449

Extension of the Isobolographic Approach to Interactions Studies between More than Two Drugs: Illustration  

E-Print Network [OSTI]

received the drugs separately or in various combinations. Drug infusion was stopped at the onset of maximal

Gelman, Andrew

450

Evaluation of the effects of a highway improvement project on Key deer  

E-Print Network [OSTI]

assessed the potential impacts of the US 1 corridor project to Key deer movements by comparing (1) radio-collared Key deer annual ranges (2) radio-collared deer corridor movements, and (3) assessing Key deer underpass and corridor use. Female and male...

Braden, Anthony Wayne

2006-10-30T23:59:59.000Z

451

Weak-Key Analysis of POET Mohamed Ahmed Abdelraheem, Andrey Bogdanov, and Elmar Tischhauser  

E-Print Network [OSTI]

Weak-Key Analysis of POET Mohamed Ahmed Abdelraheem, Andrey Bogdanov, and Elmar Tischhauser,anbog,ewti}@dtu.dk Abstract. We evaluate the security of the recently proposed authenticated encryption scheme POET. We give explicit constructions for weak key classes not covered by POET's weak key testing strategy

452

Weakness of two ID-based remote mutual authentication with key agreement protocols for mobile devices  

E-Print Network [OSTI]

to achieve explicit key confirmation. We also point out Wu's scheme decreases efficiency by using the double by the traditional public-key cryptography (Rivest et al., 1978; ElGama, l985). The computation ability and battery the number of users is increased, KAC needs a large storage space to store users' public keys

453

Imnaha Subbasin Assessment May 2004259 1.2.10.3 Key Environmental Correlates  

E-Print Network [OSTI]

, such as roads, buildings, and pollution. Including these fine-scale attributes of an animal's environment whenImnaha Subbasin Assessment May 2004259 1.2.10.3 Key Environmental Correlates Key environmental conditions. Key environmental correlates are the finest scale features that help to define wildlife habitat

454

Origin of a complex key innovation in an obligate insectplant mutualism  

E-Print Network [OSTI]

Origin of a complex key innovation in an obligate insect­plant mutualism Olle Pellmyr* and Harald W, and approved January 30, 2002 (received for review November 2, 2001) Evolutionary key innovations give for studies of coevolution, and it relies on the key innovation in the moths of complex tentacles used

Krenn, Harald W.

455

Private Key Recovery Combination Attacks: On Extreme Fragility of Popular Bitcoin  

E-Print Network [OSTI]

Private Key Recovery Combination Attacks: On Extreme Fragility of Popular Bitcoin Key Management and practical operational security in bitcoin digital currency storage systems. We study the security two most used bitcoin HD Wallet key management solutions (e.g. in BIP032 and in earlier systems). These systems

456

Distribution and abundance of endangered Florida Key deer on outer islands  

E-Print Network [OSTI]

parameters has limited status assessment and management of Key deer on outer islands. Traditional survey techniques for Key deer on Big Pine and No Name keys include road-counts, strip-counts, and mark-recapture methods. However, practical limitations render...

Watts, Dominque Elijah

2007-04-25T23:59:59.000Z

457

A Key Technology Evaluation Case Study: Applying a New Middleware Architecture on the  

E-Print Network [OSTI]

A Key Technology Evaluation Case Study: Applying a New Middleware Architecture on the Enterprise, fgoedickejuzdung@informatik.uni-essen.de Abstract Decisions for key technologies, like middleware, for large scale projects are hard, because the impact and relevance of key technologies go beyond their core technological

Zdun, Uwe

458

Linear and angular retroreflecting interferometric alignment target  

DOE Patents [OSTI]

The present invention provides a method and apparatus for measuring both the linear displacement and angular displacement of an object using a linear interferometer system and an optical target comprising a lens, a reflective surface and a retroreflector. The lens, reflecting surface and retroreflector are specifically aligned and fixed in optical connection with one another, creating a single optical target which moves as a unit that provides multi-axis displacement information for the object with which it is associated. This displacement information is useful in many applications including machine tool control systems and laser tracker systems, among others.

Maxey, L. Curtis (Powell, TN)

2001-01-01T23:59:59.000Z

459

Prototyping of the ILC Baseline Positron Target  

SciTech Connect (OSTI)

The ILC positron system uses novel helical undulators to create a powerful photon beam from the main electron beam. This beam is passed through a titanium target to convert it into electron-positron pairs. The target is constructed as a 1 m diameter wheel spinning at 2000 RPM to smear the 1 ms ILC pulse train over 10 cm. A pulsed flux concentrating magnet is used to increase the positron capture efficiency. It is cooled to liquid nitrogen temperatures to maximize the flatness of the magnetic field over the 1 ms ILC pulse train. We report on prototyping effort on this system.

Gronberg, J; Brooksby, C; Piggott, T; Abbott, R; Javedani, J; Cook, E

2012-02-29T23:59:59.000Z

460

ALT-3 Target & CMU Version 4  

SciTech Connect (OSTI)

The third Advance Liner Technology (ALT-3) experiment is the next in a long tradition of collaborations between LANL and RFNC/VNIIEF in high-explosive pulsed-power. Here a VNIIEF provided Disk Explosive Magnetic Generator (DEMG) will drive a LANL provided experimental load and diagnostic package. The objective of the experiment is to explore the use of a cylindrical liner-ontarget in tera-Pascal equation of state measurement. This presentation will discuss version 4 of the experimental target and central measuring unit (CMU) along with R & D already performed in fabrication of the target.

Griego, Jeffrey R [Los Alamos National Laboratory; Atchison, Walter L. [Los Alamos National Laboratory; Holtkamp, David [Los Alamos National Laboratory; Oro, David M. [Los Alamos National Laboratory; Reinovsky, Robert E. [Los Alamos National Laboratory; Rousculp, Christopher L. [Los Alamos National Laboratory; Tabaka, Leonard J. [Los Alamos National Laboratory

2012-06-11T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Recent developments in zinc oxide target chemistry  

SciTech Connect (OSTI)

Zinc oxide targets irradiated with high energy protons at the Los Alamos Meson Physics Facility (LAMPF) contain a number of radioactive spallation products in quantities large enough to warrant recovery. This paper describes methods for recovering {sup 7}Be, {sup 46}Sc, and {sup 48}V from such targets and offers suggestions on possible ways to recover additional isotopes. The proposed methods are based on traditional precipitation and ion exchange techniques, are readily adaptable to hot cell use, and produce no hazardous waste components. The products are obtained in moderate to high yields and have excellent radiopurity.

Heaton, R.C.; Taylor, W.A.; Phillips, D.R.; Jamriska, D.J. Sr.; Garcia, J.B.

1994-04-01T23:59:59.000Z

462

Neutron single target spin asymmetries in SIDIS  

SciTech Connect (OSTI)

The experiment E06-010 in Hall A at Jefferson Lab took data between November 2008 and February 2009 to directly measure, for the first time, the pion (and kaon) single "neutron" target-spin asymmetry (SSA) in semi-inclusive DIS from a polarized 3He target. Collins, Sivers (and Pretzelosity) neutron asymmetries are going to be extracted from the measured SSA. Details of the experiment are described together with the preliminary results of the ongoing analysis. Near future Hall A experiments on transverse nucleon spin structure are shorty reviewed.

Evaristo Cisbani

2010-04-01T23:59:59.000Z

463

Status of T2K Target 2nd Oxford-Princeton High-Power Target Workshop  

E-Print Network [OSTI]

Graphite (ToyoTanso IG-43) Current Target Design Helium cooling Graphite to titanium diffusion bond 47.0 46-Power Target Workshop Mike Fitton IG43 Graphite diffusion bonded into Ti-6Al-4V titanium, Special Techniques Group at UKAEA Culham Diffusion Bond + Graphite-Graphite bonding test Aluminium intermediate layer

McDonald, Kirk

464

What is TARGET? The Transnational Applied Research in Gender Equity Training (TARGET) project focuses on the  

E-Print Network [OSTI]

and strategies in the developing world. Articles have been culled from major academic search engines and have and present research results in academic and applied contexts What are TARGET Activities? Database Preparation TARGET participants have surveyed academic databases and are developing a searchable bibliography

Sheridan, Jennifer

465

High efficiency proton beam generation through target thickness control in femtosecond laser-plasma interactions  

SciTech Connect (OSTI)

Bright proton beams with maximum energies of up to 30?MeV have been observed in an experiment investigating ion sheath acceleration driven by a short pulse (<50 fs) laser. The scaling of maximum proton energy and total beam energy content at ultra-high intensities of ?10{sup 21} W cm{sup ?2} was investigated, with the interplay between target thickness and laser pre-pulse found to be a key factor. While the maximum proton energies observed were maximised for ?m-thick targets, the total proton energy content was seen to peak for thinner, 500?nm, foils. The total proton beam energy reached up to 440 mJ (a conversion efficiency of 4%), marking a significant step forward for many laser-driven ion applications. The experimental results are supported by hydrodynamic and particle-in-cell simulations.

Green, J. S., E-mail: james.green@stfc.ac.uk; Robinson, A. P. L.; Booth, N.; Carroll, D. C.; Rusby, D.; Wilson, L. [Central Laser Facility, STFC Rutherford Appleton Laboratory, Chilton, Oxon OX11 0QX (United Kingdom); Dance, R. J. [York Plasma Institute, Department of Physics, University of York, York YO10 5DD (United Kingdom); Gray, R. J.; MacLellan, D. A.; McKenna, P. [SUPA, Department of Physics, University of Strathclyde, Glasgow G4 0NG (United Kingdom); Murphy, C. D. [SUPA, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JZ (United Kingdom)

2014-05-26T23:59:59.000Z

466

SciTech Connect: Drug Retention Times  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systems controllerAdditiveBetatronAerogelDistances fromUsage SystemDrug

467

DRUG TESING PANEL & CUTOFF CONCENTRATIONS  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phases onOrganizationElectronic2005-2007 Budget Dear2, 2011DREAM toolDRUG

468

High Power Target Design and Operational Considerations  

E-Print Network [OSTI]

remote handling is a major driving requirement). #12;3 Managed by UT-Battelle for the U.S. Department Issues · Steady state power handling. ­ Cooling of target/enclosure window ­ wettability. ­ Hot spots systems: ­ Mercury loop operation. ­ Remote handling. · Nuclear data. #12;4 Managed by UT

McDonald, Kirk

469

High density laser-driven target  

DOE Patents [OSTI]

A high density target for implosion by laser energy composed of a central quantity of fuel surrounded by a high-Z pusher shell with a low-Z ablator-pusher shell spaced therefrom forming a region filled with low-density material.

Lindl, John D. (San Ramon, CA)

1981-01-01T23:59:59.000Z

470

Radioactive Target Detection Using Wireless Sensor Network  

E-Print Network [OSTI]

. By using the physical law for nuclear radiation isotopes, this chapter proposes a statistical method for wireless sensor network data to detect and locate a hidden nuclear target in a large study area. The method shown that the proposed method is effective and efficient in detection and location of the nuclear

Zhang, Tonglin

471

The Case for Magnetized Target Fusion (MTF)  

E-Print Network [OSTI]

of conventional unmagnetized targets by orders of magnitude; (b) makes fusion "easier" for any driver; (c) makes) drivers feasible; (d) allows experimentation at much higher energy (e.g., 20 MJ implosion kinetic energy can reduce the required radial convergence to drivers can lead to a new fusion

472

Manufacturing complex silica aerogel target components  

SciTech Connect (OSTI)

Aerogel is a material used in numerous components in High Energy Density Physics targets. In the past these components were molded into the proper shapes. Artifacts left in the parts from the molding process, such as contour irregularities from shrinkage and density gradients caused by the skin, have caused LANL to pursue machining as a way to make the components.

Defriend Obrey, Kimberly Ann [Los Alamos National Laboratory; Day, Robert D [Los Alamos National Laboratory; Espinoza, Brent F [Los Alamos National Laboratory; Hatch, Doug [Los Alamos National Laboratory; Patterson, Brian M [Los Alamos National Laboratory; Feng, Shihai [Los Alamos National Laboratory

2008-01-01T23:59:59.000Z

473

0 10 20 30 40 Target Present  

E-Print Network [OSTI]

.tropicalisland.de Global spatial guidance results Guidance effectively reduces the set size to one third of the total Target Present ReactionTime(msec) Set Size Where would you look? Guiding visual search with global? Guiding visual search with global spatial information. Jeremy M Wolfe1,2 , Ester Reijnen3 , Hareem Ahmad4

474

UKNF 12 January 2005 Target Studies  

E-Print Network [OSTI]

. #12;to vacuum pump heater test wire insulators to pulsed power supply to pulsed power supply water in the target. So a new plan is needed #12;The New Plan 1. Pulsed ohmic-heating of wires replicates beam-DYNA. 4.The VISAR can be made in Laser Division at RAL. 5. Calculate the pion yield, beam heating

McDonald, Kirk

475

Target Options for a Neutrino Factory  

E-Print Network [OSTI]

;Fluidised tungsten powder: broadly compatible with baseline 1 2 3 4 Rig contains 100 kg Tungsten IncreasingDriverPressure #12;Schematic of implementation as a Neutrino Factory target Tungsten powder hopper configurations possible #12;Pion+muon production for variable length 50% material fraction W vs 100% Hg rbeam

McDonald, Kirk

476

The generation of shared cryptographic keys through channel impulse response estimation at 60 GHz.  

SciTech Connect (OSTI)

Methods to generate private keys based on wireless channel characteristics have been proposed as an alternative to standard key-management schemes. In this work, we discuss past work in the field and offer a generalized scheme for the generation of private keys using uncorrelated channels in multiple domains. Proposed cognitive enhancements measure channel characteristics, to dynamically change transmission and reception parameters as well as estimate private key randomness and expiration times. Finally, results are presented on the implementation of a system for the generation of private keys for cryptographic communications using channel impulse-response estimation at 60 GHz. The testbed is composed of commercial millimeter-wave VubIQ transceivers, laboratory equipment, and software implemented in MATLAB. Novel cognitive enhancements are demonstrated, using channel estimation to dynamically change system parameters and estimate cryptographic key strength. We show for a complex channel that secret key generation can be accomplished on the order of 100 kb/s.

Young, Derek P.; Forman, Michael A.; Dowdle, Donald Ryan

2010-09-01T23:59:59.000Z

477

Secure Cryptographic Key Management System (CKMS) Considerations for Smart Grid Devices  

SciTech Connect (OSTI)

In this paper, we examine some unique challenges associated with key management in the Smart Grid and concomitant research initiatives: 1) effectively model security requirements and their implementations, and 2) manage keys and key distribution for very large scale deployments such as Smart Meters over a long period of performance. This will set the stage to: 3) develop innovative, low cost methods to protect keying material, and 4) provide high assurance authentication services. We will present our perspective on key management and will discuss some key issues within the life cycle of a cryptographic key designed to achieve the following: 1) control systems designed, installed, operated, and maintained to survive an intentional cyber assault with no loss of critical function, and 2) widespread implementation of methods for secure communication between remote access devices and control centers that are scalable and cost-effective to deploy.

Abercrombie, Robert K [ORNL] [ORNL; Sheldon, Frederick T [ORNL] [ORNL; Aldridge, Hal [ORNL] [ORNL; Duren, Mike [Sypris Electronics, LLC] [Sypris Electronics, LLC; Ricci, Tracy [Sypris Electronics, LLC] [Sypris Electronics, LLC; Bertino, Elisa [ORNL] [ORNL; Kulatunga, Athula [Purdue University] [Purdue University; Navaratne, Uditha Sudheera [Purdue University] [Purdue University

2011-01-01T23:59:59.000Z

478

Atomic Beam Merging and Suppression of Alkali Contaminants in Multi Body High Power Targets: Design and Test of Target and Ion Source Prototypes at ISOLDE  

E-Print Network [OSTI]

The next generation of high power ISOL-facilities will deliver intense and pure radioactive ion beams. Two key issues of developments mandatory for the forthcoming generation of ISOL target-ion source units are assessed and demonstrated in this thesis. The design and production of target and ion-source prototypes is described and dedicated measurements at ISOLDE-CERN of their radioisotope yields are analyzed. The purity of short lived or rare radioisotopes suffer from isobaric contaminants, notably alkalis which are highly volatile and easily ionized elements. Therefore, relying on their chemical nature, temperature controlled transfer lines were equipped with a tube of quartz that aimed at trapping these unwanted elements before they reached the ion source. The successful application yields high alkali-suppression factors for several elements (ie: 80, 82mRb, 126, 142Cs, 8Li, 46K, 25Na, 114In, 77Ga, 95, 96Sr) for quartz temperatures between 300C and 1100C. The enthalpies of adsorption on quartz were measu...

Bouquerel, Elian J A; Lettry, J; Stora, T

2009-01-01T23:59:59.000Z

479

Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem  

E-Print Network [OSTI]

Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem of alcoholism and drug

Wu, Mingshen

480

antidepressant drug treatment: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

prognosis. ... Scott, Alexander Wesley 2010-01-01 50 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

antiretroviral drug exposure: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

SKILLS AQUIRED THROUGH Auerbach, Scott M. 2 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

482

antiretroviral drug combination: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

carrying various combinations Ahlers, Guenter 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

483

antidepressant drug design: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ylenedioxymethamphetamine (MDMA) also known as Ecstasy is a common recreational drug of abuse and reports of abuse of tricyclic antidepressants are also known. We report two cases...

484

Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs  

E-Print Network [OSTI]

Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

Wu, Peter I-Kung

2007-01-01T23:59:59.000Z

485

In silico modeling to predict drug-induced phospholipidosis  

SciTech Connect (OSTI)

Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A principal characteristic of drugs inducing DIPL is known to be a cationic amphiphilic structure. This provides evidence for a structure-based explanation and opportunity to analyze properties and structures of drugs with the histopathologic findings for DIPL. In previous work from the FDA, in silico quantitative structureactivity relationship (QSAR) modeling using machine learning approaches has shown promise with a large dataset of drugs but included unconfirmed data as well. In this study, we report the construction and validation of a battery of complementary in silico QSAR models using the FDA's updated database on phospholipidosis, new algorithms and predictive technologies, and in particular, we address high performance with a high-confidence dataset. The results of our modeling for DIPL include rigorous external validation tests showing 8081% concordance. Furthermore, the predictive performance characteristics include models with high sensitivity and specificity, in most cases above ? 80% leading to desired high negative and positive predictivity. These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL. - Highlights: New in silico models for predicting drug-induced phospholipidosis (DIPL) are described. The training set data in the models is derived from the FDA's phospholipidosis database. We find excellent predictivity values of the models based on external validation. The models can support drug screening and regulatory decision-making on DIPL.

Choi, Sydney S.; Kim, Jae S.; Valerio, Luis G., E-mail: luis.valerio@fda.hhs.gov; Sadrieh, Nakissa

2013-06-01T23:59:59.000Z

486

Unlocking enzyme synthesis of rare sugars to create drugs with...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

this study is to dramatically improve the performance of enzymes that can be used by the pharmaceutical industry to synthesize drug precursors," said ORNL's Andrey Kovalevsky, the...

487

antimalarial drug artemisinin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Isolation of Artemisinin as Antimalarial Drugs from Artemisia annua L. Cultivated in Indonesia CiteSeer Summary: Abstract-- Malaria disease is endemic in developing countries like...

488

act drug policies: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of alcoholic beverages. These standards conform to state and federal laws. The policy described in this brochure pertains to alcohol and other drug use behaviors in...

489

antithyroid drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

490

antidiabetic drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

491

antiretroviral drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

492

antipsychotic drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

493

adverse drug events: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

494

adverse drug event: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

495

antiepileptic drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

496

antiarrhythmic drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

497

acute drug intoxication: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

498

adhd drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

499

antihypertensive drug therapy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

500

Transdermal microconduits by microscission for drug delivery and sample acquisition  

E-Print Network [OSTI]

Background Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...

Gonzalez, Salvador