National Library of Energy BETA

Sample records for key drug target

  1. Automated High Throughput Drug Target Crystallography

    SciTech Connect (OSTI)

    Rupp, B

    2005-02-18

    The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

  2. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally ... transcription and replication and is a prime target of antibacterial and anticancer drugs. ...

  3. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has ...

  4. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II

  5. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  6. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  7. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  8. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  9. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  10. TARGET SELECTION FOR THE LBTI EXOZODI KEY SCIENCE PROGRAM

    SciTech Connect (OSTI)

    Weinberger, Alycia J.; Bryden, Geoff; Mennesson, Bertrand; Serabyn, Eugene; Kennedy, Grant M.; Wyatt, Mark C.; Roberge, Aki; Danchi, William C.; Stapelfeldt, Karl R.; Defrère, Denis; Hinz, Philip M.; Rieke, George; Bailey, Vanessa P.; Skemer, Andrew J.; Millan-Gabet, Rafael; Haniff, Chris

    2015-02-01

    The Hunt for Observable Signatures of Terrestrial planetary Systems (HOSTS) on the Large Binocular Telescope Interferometer will survey nearby stars for faint emission arising from ∼300 K dust (exozodiacal dust), and aims to determine the exozodiacal dust luminosity function. HOSTS results will enable planning for future space telescopes aimed at direct spectroscopy of habitable zone terrestrial planets, as well as greater understanding of the evolution of exozodiacal disks and planetary systems. We lay out here the considerations that lead to the final HOSTS target list. Our target selection strategy maximizes the ability of the survey to constrain the exozodi luminosity function by selecting a combination of stars selected for suitability as targets of future missions and as sensitive exozodi probes. With a survey of approximately 50 stars, we show that HOSTS can enable an understanding of the statistical distribution of warm dust around various types of stars and is robust to the effects of varying levels of survey sensitivity induced by weather conditions.

  11. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M.; Nikanjam, Mina

    2012-08-28

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  12. Increasing the structural coverage of tuberculosis drug targets

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Baugh, Loren; Phan, Isabelle; Begley, Darren W.; Clifton, Matthew C.; Armour, Brianna; Dranow, David M.; Taylor, Brandy M.; Muruthi, Marvin M.; Abendroth, Jan; Fairman, James W.; et al

    2014-12-19

    High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus “homolog-rescue” strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. We found that of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structuresmore » would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Cα RMSD <1 Å, >85% side chain identity, and ≥80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.« less

  13. International Experience with Key Program Elements of IndustrialEnergy Efficiency or Greenhouse Gas Emissions Reduction Target-SettingPrograms

    SciTech Connect (OSTI)

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-02-02

    Target-setting agreements, also known as voluntary ornegotiated agreements, have been used by a number of governments as amechanism for promoting energy efficiency within the industrial sector. Arecent survey of such target-setting agreement programs identified 23energy efficiency or GHG emissions reduction voluntary agreement programsin 18 countries. International best practice related to target-settingagreement programs calls for establishment of a coordinated set ofpolicies that provide strong economic incentives as well as technical andfinancial support to participating industries. The key program elementsof a target-setting program are the target-setting process,identification of energy-saving technologies and measures usingenergy-energy efficiency guidebooks and benchmarking as well as byconducting energy-efficiency audits, development of an energy-savingsaction plan, development and implementation of energy managementprotocols, development of incentives and supporting policies, monitoringprogress toward targets, and program evaluation. This report firstprovides a description of three key target-setting agreement programs andthen describes international experience with the key program elementsthat comprise such programs using information from the three keytarget-setting programs as well as from other international programsrelated to industrial energy efficiency or GHG emissionsreductions.

  14. Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite for targeted drug delivery

    SciTech Connect (OSTI)

    Gu, Lina; He, Xiaomei; Wu, Zhenyu

    2014-11-15

    Highlights: Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite was synthesized by a simple, efficient and environmental friendly method. The prepared material had a large surface area, high pore volume, and good magnetic separability. DOX-loaded Fe{sub 3}O{sub 4}/hydroxyapatite composite exhibited surprising slow drug release behavior and pH-dependent behavior. - Abstract: In this contribution, we introduced a simple, efficient, and green method of preparing a mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite (HA) composite. The as-prepared material had a large surface area, high pore volume, and good magnetic separability, which made it suitable for targeted drug delivery systems. The chemotherapeutic agent doxorubicin (DOX) was used to investigate the drug release behavior of Fe{sub 3}O{sub 4}/HA composite. The drug release profiles displayed a little burst effect and pH-dependent behavior. The release rate of DOX at pH 5.8 was larger than that at pH 7.4, which could be attributed to DOX protonation in acid medium. In addition, the released DOX concentrations remained at 0.83 and 1.39 ?g/ml at pH 7.4 and 5.8, respectively, which indicated slow, steady, and safe release rates. Therefore, the as-prepared Fe{sub 3}O{sub 4}/hydroxyapatite composite could be an efficient platform for targeted anticancer drug delivery.

  15. Key Elements of and Materials Performance Targets for Highly Insulating Window Frames

    SciTech Connect (OSTI)

    Gustavsen, Arild; Grynning, Steinar; Arasteh, Dariush; Jelle, Bjorn Petter; Goudey, Howdy

    2011-03-28

    The thermal performance of windows is important for energy efficient buildings. Windows typically account for about 30-50 percent of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U-factor of their opaque counterparts (wall, roof and floor constructions). In well insulated buildings the U-factor of walls, roofs an floors can be between 0.1-0.2 W/(m2K). The best windows have U-values of about 0.7-1.0. It is therefore obvious that the U-factor of windows needs to be reduced, even though looking at the whole energy balance for windows (i.e. solar gains minus transmission losses) makes the picture more complex.In high performance windows the frame design and material use is of utmost importance, as the frame performance is usually the limiting factor for reducing the total window U-factor further. This paper describes simulation studies analyzing the effects on frame and edge-of-glass U-factors of different surface emissivities as well as frame material and spacer conductivities. The goal of this work is to define materials research targets for window frame components that will result in better frame thermal performance than is exhibited by the best products available on the market today.

  16. Sandia, UCLA develop screening libraries to discover drug targets for viral

    National Nuclear Security Administration (NNSA)

    infections | National Nuclear Security Administration | (NNSA) Sandia, UCLA develop screening libraries to discover drug targets for viral infections Friday, April 22, 2016 - 12:00am From left, Sandia National Laboratories researchers Oscar Negrete, Edwin Saada and Sara Bird check out a CRISPR library preparation. The work is part of the first-ever Cooperative Research and Development Agreement between Sandia and UCLA. As headlines highlight the threat of viruses like Ebola and Zika,

  17. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Forte, Trudy

    2011-04-28

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  18. Targets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    that require a complex interplay among target designers, materials scientists, and ... As a result, target components must be machined to an accuracy of 1 micron, or 1 millionth ...

  19. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo; Ji, Nan; Pan, Wen; Hong, Ru; Wang, Hao; Ji, Zhi-Liang

    2014-01-01

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: A novel computational framework was developed for mechanistic study of SADRs. Off-targets of drugs were identified in large scale and in a high-throughput manner. SADRs like cardiac disorders were systematically explored in molecular networks. A number of ADR-associated proteins were identified.

  20. Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion

    SciTech Connect (OSTI)

    Knobloch, M.; Portier, C.J.; Levionnois, O.L.; Theurillat, R.; Thormann, W.; Spadavecchia, C.; Mevissen, M. . E-mail: meike.mevissen@vpi.unibe.ch

    2006-11-01

    Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 {mu}g/ml S-ketamine over 120 min under isoflurane anesthesia was performed in Shetland ponies. A quantitative electromyographic assessment of the NWR was done before, during and after the TCI. Plasma levels of R-/S-ketamine and R-/S-norketamine were determined by enantioselective capillary electrophoresis. These data and two additional data sets from bolus studies were used to build a PBPk model for ketamine in ponies. The peak-to-peak amplitude and the duration of the NWR decreased significantly during TCI and returned slowly toward baseline values after the end of TCI. The PBPk model provides reliable prediction of plasma and tissue levels of R- and S-ketamine and R- and S-norketamine. Furthermore, biotransformation of ketamine takes place in the liver and in the lung via first-pass metabolism. Plasma concentrations of S-norketamine were higher compared to R-norketamine during TCI at all time points. Analysis of the data suggested identical biotransformation rates from the parent compounds to the principle metabolites (R- and S-norketamine) but different downstream metabolism to further metabolites. The PBPk model can provide predictions of R- and S-ketamine and norketamine concentrations in other clinical settings (e.g. horses)

  1. Target

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lifetime measurements in inverse kinematics Coulex Target e.g. C Stopper e.g. Cu Beam X X * C Si-Det. Yale Plunger 120 Te at 300 MeV Plunger foils Si-Detector Compton-suppressed ...

  2. KEY PERSONNEL

    National Nuclear Security Administration (NNSA)

    by Mods 002, 006, 020, 029, 0049, 0065, 0084, 0091, 0106) DE-NA0000622 Section J, Appendix J, Page 1 SECTION J APPENDIX J KEY PERSONNEL 7/06/2015 TITLE NAME President Christopher C. Gentile Vice President, Engineering Robin Stubenhofer Vice President, Integrated Supply Chain Rick Lavelock Director, Sr. Program Management Org. Vacant Director, Integrated Supply Chain Kurt Lorenzen Director, Engineering Bob Chaney Director, Quality David Schoenherr Director, Information Technology Matt Decker

  3. Key Outcomes:

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Points & Action Items Inaugural Meeting Thursday, August 25, 2011 Renaissance Denver Hotel Denver, Colorado Participants Tracey LeBeau, Director, Pilar Thomas, Deputy Director, and Brandt Petrasek, Special Assistant, Department of Energy, Office of Indian Energy Policy and Programs; Vice Chairman Ronald Suppah and Jim Manion, Confederated Tribes of the Warm Springs Reservation of Oregon; William Micklin, Ewiiaapaayp Band of Kumeyaay Indians; Councilman Barney Enos, Jr., Jason Hauter,

  4. Identification of a Novel Drug Lead That Inhibits HCV Infection and Cell-to-Cell Transmission by Targeting the HCV E2 Glycoprotein

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Al Olaby, Reem R.; Cocquerel, Laurence; Zemla, Adam; Saas, Laure; Dubuisson, Jean; Vielmetter, Jost; Marcotrigiano, Joseph; Khan, Abdul Ghafoor; Catalan, Felipe Vences; Perryman, Alexander L.; et al

    2014-10-30

    We report that Hepatitis C Virus (HCV) infects 200 million individuals worldwide. Although several FDA approved drugs targeting the HCV serine protease and polymerase have shown promising results, there is a need for better drugs that are effective in treating a broader range of HCV genotypes and subtypes without being used in combination with interferon and/or ribavirin. Recently, two crystal structures of the core of the HCV E2 protein (E2c) have been determined, providing structural information that can now be used to target the E2 protein and develop drugs that disrupt the early stages of HCV infection by blocking E2’smore » interaction with different host factors. Using the E2c structure as a template, we have created a structural model of the E2 protein core (residues 421–645) that contains the three amino acid segments that are not present in either structure. Computational docking of a diverse library of 1,715 small molecules to this model led to the identification of a set of 34 ligands predicted to bind near conserved amino acid residues involved in the HCV E2: CD81 interaction. We used surface plasmon resonance detection to screen the ligand set for binding to recombinant E2 protein, and the best binders were subsequently tested to identify compounds that inhibit the infection of Huh-7 cells by HCV. One compound, 281816, blocked E2 binding to CD81 and inhibited HCV infection in a genotype-independent manner with IC50’s ranging from 2.2 µM to 4.6 µM. 281816 blocked the early and late steps of cell-free HCV entry and also abrogated the cell-to-cell transmission of HCV. Collectively the results obtained with this new structural model of E2c suggest the development of small molecule inhibitors such as 281816 that target E2 and disrupt its interaction with CD81 may provide a new paradigm for HCV treatment.« less

  5. Identification of a Novel Drug Lead That Inhibits HCV Infection and Cell-to-Cell Transmission by Targeting the HCV E2 Glycoprotein

    SciTech Connect (OSTI)

    Al Olaby, Reem R.; Cocquerel, Laurence; Zemla, Adam; Saas, Laure; Dubuisson, Jean; Vielmetter, Jost; Marcotrigiano, Joseph; Khan, Abdul Ghafoor; Catalan, Felipe Vences; Perryman, Alexander L.; Freundlich, Joel S.; Forli, Stefano; Levy, Shoshana; Balhorn, Rod; Azzazy, Hassan M.

    2014-10-30

    We report that Hepatitis C Virus (HCV) infects 200 million individuals worldwide. Although several FDA approved drugs targeting the HCV serine protease and polymerase have shown promising results, there is a need for better drugs that are effective in treating a broader range of HCV genotypes and subtypes without being used in combination with interferon and/or ribavirin. Recently, two crystal structures of the core of the HCV E2 protein (E2c) have been determined, providing structural information that can now be used to target the E2 protein and develop drugs that disrupt the early stages of HCV infection by blocking E2’s interaction with different host factors. Using the E2c structure as a template, we have created a structural model of the E2 protein core (residues 421–645) that contains the three amino acid segments that are not present in either structure. Computational docking of a diverse library of 1,715 small molecules to this model led to the identification of a set of 34 ligands predicted to bind near conserved amino acid residues involved in the HCV E2: CD81 interaction. We used surface plasmon resonance detection to screen the ligand set for binding to recombinant E2 protein, and the best binders were subsequently tested to identify compounds that inhibit the infection of Huh-7 cells by HCV. One compound, 281816, blocked E2 binding to CD81 and inhibited HCV infection in a genotype-independent manner with IC50’s ranging from 2.2 µM to 4.6 µM. 281816 blocked the early and late steps of cell-free HCV entry and also abrogated the cell-to-cell transmission of HCV. Collectively the results obtained with this new structural model of E2c suggest the development of small molecule inhibitors such as 281816 that target E2 and disrupt its interaction with CD81 may provide a new paradigm for HCV treatment.

  6. Key Activities

    Broader source: Energy.gov [DOE]

    We partner with industry, small business, universities, regional entities, and other stakeholders to identify and invest in emerging clean energy technologies. We establish collaborative communities focused on developing and commercializing targeted technologies; play a leadership role in the national interagency Advanced Manufacturing Partnership; and encourage a culture of continuous improvement in corporate energy management. Our investments have high impact, use project diversity to spread risk, target nationally important innovation at critical decision points, and contribute to quantifiable energy savings. By reducing the life-cycle energy consumption of manufactured goods by 50 percent over 10 years, we will support the creation of high-quality domestic manufacturing jobs and enhance the competitiveness of the United States. EERE's Clean Energy Manufacturing Initiative (CEMI) connects AMO's investments in the development of innovative process and materials technologies over 3 decades with R&D in other EERE offices and focuses on the urgent economic opportunities in U.S. clean energy manufacturing to strengthen U.S. competitiveness across multiple manufacturing industries through increased energy productivity.

  7. Key Agency Targets Summary _FY 2012_.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    all projects in the capital work plan; and 3) At least 80% of Capital Allocation Board (CAB) approved "major capital investment" projectprogram elements of cost, schedule, and...

  8. NSR Key Number Retrieval

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NSR Key Number Retrieval Pease enter key in the box Submit

  9. Study reveals structure of tuberculosis enzyme, could offer drug...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of tuberculosis enzyme, could offer drug target By Louise Lerner * November 2, 2015 Tweet ... Researchers have been interested in the mycobacterium IMPDH enzyme as a drug target for ...

  10. Prescription Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue...

  11. Key Steps | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Steps The Postdoctoral Program Office welcomes you to Argonne National Laboratory. Your academic achievements and demonstrated research capabilities will undoubtedly contribute to the continuing scientific and technological success of the Laboratory. It is our intention that your tenure at Argonne be as productive and rewarding as possible. Your goals and needs may evolve as you progress through your appointment. We take the approach of providing guidance, resources and programs targeted to

  12. Public Key Cryptography and Key Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-02-15

    The use and management of certificate-based public key cryptography for the Department of Energy (DOE) requires the establishment of a public key infrastructure (PKI). This chapter defines the policy related to roles, requirements, and responsibilities for establishing and maintaining a DOE PKI and the documentation necessary to ensure that all certificates are managed in a manner that maintains the overall trust required to support a viable PKI. Canceled by DOE N 251.112.

  13. Group key management

    SciTech Connect (OSTI)

    Dunigan, T.; Cao, C.

    1997-08-01

    This report describes an architecture and implementation for doing group key management over a data communications network. The architecture describes a protocol for establishing a shared encryption key among an authenticated and authorized collection of network entities. Group access requires one or more authorization certificates. The implementation includes a simple public key and certificate infrastructure. Multicast is used for some of the key management messages. An application programming interface multiplexes key management and user application messages. An implementation using the new IP security protocols is postulated. The architecture is compared with other group key management proposals, and the performance and the limitations of the implementation are described.

  14. Key Milestones/Outlook

    Office of Energy Efficiency and Renewable Energy (EERE)

    Key Milestones/Outlook per the Department of Energy 2015 Congressional Budget Request, Environmental Management, March 2014

  15. Quantum dense key distribution

    SciTech Connect (OSTI)

    Degiovanni, I.P.; Ruo Berchera, I.; Castelletto, S.; Rastello, M.L.; Bovino, F.A.; Colla, A.M.; Castagnoli, G.

    2004-03-01

    This paper proposes a protocol for quantum dense key distribution. This protocol embeds the benefits of a quantum dense coding and a quantum key distribution and is able to generate shared secret keys four times more efficiently than the Bennet-Brassard 1984 protocol. We hereinafter prove the security of this scheme against individual eavesdropping attacks, and we present preliminary experimental results, showing its feasibility.

  16. Key Events Timeline

    Broader source: Energy.gov [DOE]

    This document lists key events beginning with the April 20 fire on the Deepwater Horizon through July 28th. Updated July 28, 2010.

  17. SSH Key Fingerprints

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SSH Key Fingerprints SSH Key Fingerprints Occasionally maintenance on NERSC systems results in the SSH host key changing. On the first time you attempt to log in after this, ssh will stop with a warning like: "WARNING: REMOTE HOST IDENTIFICATION HAS CHANGED!" (Linux/Mac) or "WARNING - POTENTIAL SECURITY BREACH!" (Windows) Do not ignore these warnings! The correct host key fingerprint for Cori is: 2048 SHA256:mR3sHwHorgjqRlUbggtfOCa768/uKdbNb2TOH8xDMn8 You can replace entries

  18. Targeting the tumor microenvironment

    SciTech Connect (OSTI)

    Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

    2006-11-07

    Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

  19. Optical key system

    SciTech Connect (OSTI)

    Hagans, Karla G.; Clough, Robert E.

    2000-01-01

    An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

  20. Optical key system

    SciTech Connect (OSTI)

    Hagans, K.G.; Clough, R.E.

    2000-04-25

    An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

  1. Public Key FPGA Software

    Energy Science and Technology Software Center (OSTI)

    2013-07-25

    The Public Key (PK) FPGA software performs asymmetric authentication using the 163-bit Elliptic Curve Digital Signature Algorithm (ECDSA) on an embedded FPGA platform. A digital signature is created on user-supplied data, and communication with a host system is performed via a Serial Peripheral Interface (SPI) bus. Software includes all components necessary for signing, including custom random number generator for key creation and SHA-256 for data hashing.

  2. Key Activities | Department of Energy

    Energy Savers [EERE]

    About the Fuel Cell Technologies Office Key Activities Key Activities The Fuel Cell Technologies Office conducts work in several key areas to advance the development and ...

  3. Cryptographic Key Management System

    SciTech Connect (OSTI)

    No, author

    2014-02-21

    This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

  4. Target Chamber

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Who Partners with NIF? FAQs Visit Us home about how nif works beamline target chamber Target Chamber The "Grand Central Station" of the National Ignition Facility is the ...

  5. NREL Makes Key Appointments

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Makes Key Appointments Staffing for Distributed Energy and Tech Management Announced For more information contact: Gary Schmitz, 303-275-4050 email: Gary Schmitz Golden, Colo., Feb. 28, 2001 - Two veterans of energy research have been named to newly created positions at the U.S. Department of Energy's National Renewable Energy Laboratory. Jack Darnell was named Deputy Associate Director for NREL's recently reorganized Planning and Technology Management Division. Anthony Schaffhauser has been

  6. Sputter target

    DOE Patents [OSTI]

    Gates, Willard G.; Hale, Gerald J.

    1980-01-01

    The disclosure relates to an improved sputter target for use in the deposition of hard coatings. An exemplary target is given wherein titanium diboride is brazed to a tantalum backing plate using a gold-palladium-nickel braze alloy.

  7. Key Terms | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Terms Key Terms Three Door Keys data-key-571156_960_720.png Key Terms Low Vision: non-correctable reduced vision Blindness: lack of visual perception Hearing Impairment: full or partial decrease in the ability to detect or understand sounds Physical Impairment: a physical condition that permanently prevents normal body movement or control Cognitive Disabilities: difficulty with one or more types of mental tasks

  8. LIQUID TARGET

    DOE Patents [OSTI]

    Martin, M.D.; Salsig, W.W. Jr.

    1959-01-13

    A liquid handling apparatus is presented for a liquid material which is to be irradiated. The apparatus consists essentially of a reservoir for the liquid, a target element, a drain tank and a drain lock chamber. The target is in the form of a looped tube, the upper end of which is adapted to be disposed in a beam of atomic particles. The lower end of the target tube is in communication with the liquid in the reservoir and a means is provided to continuously circulate the liquid material to be irradiated through the target tube. Means to heat the reservoir tank is provided in the event that a metal is to be used as the target material. The apparatus is provided with suitable valves and shielding to provide maximum safety in operation.

  9. Secure key storage and distribution

    SciTech Connect (OSTI)

    Agrawal, Punit

    2015-06-02

    This disclosure describes a distributed, fault-tolerant security system that enables the secure storage and distribution of private keys. In one implementation, the security system includes a plurality of computing resources that independently store private keys provided by publishers and encrypted using a single security system public key. To protect against malicious activity, the security system private key necessary to decrypt the publication private keys is not stored at any of the computing resources. Rather portions, or shares of the security system private key are stored at each of the computing resources within the security system and multiple security systems must communicate and share partial decryptions in order to decrypt the stored private key.

  10. Key Activities | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    About the Bioenergy Technologies Office » Key Activities Key Activities The Bioenergy Technologies Office's key activities are aimed at producing a viable, sustainable domestic biomass industry that produces renewable biofuels, bioproducts and biopower; enhances U.S. energy security; reduces U.S. oil dependence; provides environmental benefits (e.g., reduced greenhouse gas emissions); and creates nationwide economic opportunities. Meeting these goals requires significant and rapid advances in

  11. Diversity & Flexibility Key to Sustainability

    Broader source: Energy.gov [DOE]

    Plenary V: Biofuels and Sustainability: Acknowledging Challenges and Confronting MisconceptionsDiversity & Flexibility Key to SustainabilityDavid Babson, Senior Fuels Engineer, Union of...

  12. Key Issues | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Issues Key Issues The following presentations offer information about other key topics related to high performance homes. wall_system_innovations_kochkin.pdf (1.48 MB) removing_codes_barriers_cole.pdf (479.86 KB) testing_residential_ariconditioners_booten_winkler.pdf (5.21 MB) code_gaps_combustion_safety.pdf (1.34 MB) automated_utility_bill_calibration_polly.pdf (1.64 MB) predicting_envelope_leakage_griffiths.pdf (1.63 MB) More Documents & Publications Code Gaps and Future Research Needs

  13. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein...

  14. Target assembly

    DOE Patents [OSTI]

    Lewis, Richard A.

    1980-01-01

    A target for a proton beam which is capable of generating neutrons for absorption in a breeding blanket includes a plurality of solid pins formed of a neutron emissive target material disposed parallel to the path of the beam and which are arranged axially in a plurality of layers so that pins in each layer are offset with respect to pins in all other layers, enough layers being used so that each proton in the beam will strike at least one pin with means being provided to cool the pins. For a 300 mA, 1 GeV beam (300 MW), stainless steel pins, 12 inches long and 0.23 inches in diameter are arranged in triangular array in six layers with one sixth of the pins in each layer, the number of pins being such that the entire cross sectional area of the beam is covered by the pins with minimum overlap of pins.

  15. Accelerator target

    DOE Patents [OSTI]

    Schlyer, David J.; Ferrieri, Richard A.; Koehler, Conrad

    1999-01-01

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  16. Accelerator target

    DOE Patents [OSTI]

    Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

    1999-06-29

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

  17. Key China Energy Statistics 2011

    SciTech Connect (OSTI)

    Levine, Mark; Fridley, David; Lu, Hongyou; Fino-Chen, Cecilia

    2012-01-15

    The China Energy Group at Lawrence Berkeley National Laboratory (LBNL) was established in 1988. Over the years the Group has gained recognition as an authoritative source of China energy statistics through the publication of its China Energy Databook (CED). In 2008 the Group published the Seventh Edition of the CED (http://china.lbl.gov/research/chinaenergy-databook). This handbook summarizes key statistics from the CED and is expressly modeled on the International Energy Agency’s “Key World Energy Statistics” series of publications. The handbook contains timely, clearly-presented data on the supply, transformation, and consumption of all major energy sources.

  18. Key China Energy Statistics 2012

    SciTech Connect (OSTI)

    Levine, Mark; Fridley, David; Lu, Hongyou; Fino-Chen, Cecilia

    2012-05-01

    The China Energy Group at Lawrence Berkeley National Laboratory (LBNL) was established in 1988. Over the years the Group has gained recognition as an authoritative source of China energy statistics through the publication of its China Energy Databook (CED). The Group has published seven editions to date of the CED (http://china.lbl.gov/research/chinaenergy-databook). This handbook summarizes key statistics from the CED and is expressly modeled on the International Energy Agency’s “Key World Energy Statistics” series of publications. The handbook contains timely, clearly-presented data on the supply, transformation, and consumption of all major energy sources.

  19. Novel targeted therapy for stomach cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Novel targeted therapy for stomach cancer Novel targeted therapy for stomach cancer This finding has the potential to save thousand of lives a year by delivering a more effective, targeted treatment for cancer patients. October 29, 2015 New research at Los Alamos National Laboratory and the Wellcome Trust Sanger Institute shows a molecular fingerprint in stomach cancer that shows it can be treated with platinum drugs and/or molecular inhibitors known as PARP (poly ADP ribose polymerase). New

  20. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent A Key Enzyme to the Potency of an Anticancer Agent Print Wednesday, 28 May 2008 00:00 Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid

  1. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  2. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  3. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  4. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  5. NREL: Energy Analysis - Key Activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Activities NREL conducts a broad range of energy analysis in support of the laboratory's programs and initiatives, DOE's Office of Energy Efficiency and Renewable Energy (EERE), technology transfer, and the greater energy analysis community. NREL's recent analysis activities include: Analysis of Project Finance Electric Sector Integration Energy-Water Nexus Life Cycle Assessment Harmonization Manufacturing Analysis Resource Assessment Printable Version Energy Analysis Home Capabilities &

  6. Smarter Drugs: How Protein Crystallography Revolutionizes Drug Design

    SciTech Connect (OSTI)

    Smith, Clyde

    2005-04-26

    According to Smith, protein crystallography allows scientists to design drugs in a much more efficient way than the standard methods traditionally used by large drug companies, which can cost close to a billion dollars and take 10 to 15 years. 'A lot of the work can be compressed down,' Smith said. Protein crystallography enables researchers to learn the structure of molecules involved in disease and health. Seeing the loops, folds and placement of atoms in anything from a virus to a healthy cell membrane gives important information about how these things work - and how to encourage, sidestep or stop their functions. Drug design can be much faster when the relationship between structure and function tells you what area of a molecule to target. Smith will use a timeline to illustrate the traditional methods of drug development and the new ways it can be done now. 'It is very exciting work. There have been some failures, but many successes too.' A new drug to combat the flu was developed in a year or so. Smith will tell us how. He will also highlight drugs developed to combat HIV, Tuberculosis, hypertension and Anthrax.

  7. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  8. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  9. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  10. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  11. Targeting NRF2 signaling for cancer chemoprevention

    SciTech Connect (OSTI)

    Kwak, Mi-Kyoung; Kensler, Thomas W.

    2010-04-01

    Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

  12. Keys to improving environmental performance

    SciTech Connect (OSTI)

    Moreau, R.L.; Raught, D.L.

    1996-11-01

    Environmental protection is a mainstream issue in today`s society. Both internal and external drivers motivate the oil and ms industry to continuously improve environmental performance. Companies are integrating environmental considerations into their business plans to a greater extent, and are directing proportionally more resources toward managing these issues. This paper addresses several environmental management focus areas in Exxon`s domestic E&P sector to: (1) manage risks, (2) ensure compliance, (3) improve performance, and (4) assist in the development of balanced legislation and regulations. Specific examples of Production Department programs are discussed, along with keys to success for continued progress in improving performance.

  13. Public/private key certification authority and key distribution. Draft

    SciTech Connect (OSTI)

    Long, J.P.; Christensen, M.J.; Sturtevant, A.P.; Johnston, W.E.

    1995-09-25

    Traditional encryption, which protects messages from prying eyes, has been used for many decades. The present concepts of encryption are built from that heritage. Utilization of modern software-based encryption techniques implies much more than simply converting files to an unreadable form. Ubiquitous use of computers and advances in encryption technology coupled with the use of wide-area networking completely changed the reasons for utilizing encryption technology. The technology demands a new and extensive infrastructure to support these functions. Full understanding of these functions, their utility and value, and the need for an infrastructure, takes extensive exposure to the new paradigm. This paper addresses issues surrounding the establishment and operation of a key management system (i.e., certification authority) that is essential to the successful implementation and wide-spread use of encryption.

  14. Key Opportunities and Challenges for Program Sustainability ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Opportunities and Challenges for Program Sustainability Key Opportunities and Challenges for Program Sustainability Better Buildings Neighborhood Program, Peer Exchange Call: ...

  15. 'Thirsty' Metals Key to Longer Battery Lifetimes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    'Thirsty' Metals Key to Longer Battery Lifetimes 'Thirsty' Metals Key to Longer Battery Lifetimes Computations at NERSC show how multiply charged metal ions impact battery capacity ...

  16. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Brain Receptor Structures Key to Future Therapeutics Print Wednesday, 28 January 2015 00:00 With an aging population in ...

  17. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Target 2 Target 2 is housed in ...

  18. Targets and target wheel mechanism for APEX

    SciTech Connect (OSTI)

    Roa, D.E.

    1995-10-01

    A rotating target wheel system built for the ATLAS Positron Experiment (APEX) will be described. It is designed so that targets can withstand the heating caused by the energy loss of intense heavy ion beams. A unique feature is the use of a digital encoder to provide logic trigger signals for beam sweeping and event-by-event target location information. Techniques for fabricating targets of tantalum, lead, thorium and uranium and the behavior of the targets during beam exposure will be discussed.

  19. Bioenergy Key Publications | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Publications Bioenergy Key Publications This overview highlights key publications issued by the U.S. Department of Energy's Bioenergy Technologies Office. bioenergy_key_publications.pdf (333.56 KB) More Documents & Publications 2013 Peer Review Presnentations-Plenaries Technology Pathway Selection Effort 2015 Peer Review Presentations-Plenaries

  20. Answering Key Fuel Cycle Questions

    SciTech Connect (OSTI)

    Steven J. Piet; Brent W. Dixon; J. Stephen Herring; David E. Shropshire; Mary Lou Dunzik-Gougar

    2003-10-01

    The Advanced Fuel Cycle Initiative (AFCI) program has both “outcome” and “process” goals because it must address both waste already accumulating as well as completing the fuel cycle in connection with advanced nuclear power plant concepts. The outcome objectives are waste geological repository capacity and cost, energy security and sustainability, proliferation resistance, fuel cycle economics, and safety. The process objectives are readiness to proceed and adaptability and robustness in the face of uncertainties. A classic decision-making approach to such a multi-attribute problem would be to weight individual quantified criteria and calculate an overall figure of merit. This is inappropriate for several reasons. First, the goals are not independent. Second, the importance of different goals varies among stakeholders. Third, the importance of different goals is likely to vary with time, especially the “energy future.” Fourth, some key considerations are not easily or meaningfully quantifiable at present. Instead, at this point, we have developed 16 questions the AFCI program should answer and suggest an approach of determining for each whether relevant options improve meeting each of the program goals. We find that it is not always clear which option is best for a specific question and specific goal; this helps identify key issues for future work. In general, we suggest attempting to create as many win-win decisions (options that are attractive or neutral to most goals) as possible. Thus, to help clarify why the program is exploring the options it is, and to set the stage for future narrowing of options, we have developed 16 questions, as follows: · What are the AFCI program goals? · Which potential waste disposition approaches do we plan for? · What are the major separations, transmutation, and fuel options? · How do we address proliferation resistance? · Which potential energy futures do we plan for? · What potential external triggers do we

  1. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  2. The Brain: Key To a Better Computer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain: Key To a Better Computer - Sandia Energy Energy Search Icon Sandia Home Locations ... Twitter Google + Vimeo Newsletter Signup SlideShare The Brain: Key To a Better Computer ...

  3. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P.

    1993-01-01

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  4. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  5. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. About Target 2 - Lead Slowing ...

  6. Advanced Target Effects Modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advanced Target Effects Modeling for Ion Accelerators and other High-Energy-Density ... ature effects, e.g., surface tension and target fragmentation, that are not generally ...

  7. Drug interactions evaluation: An integrated part of risk assessment of therapeutics

    SciTech Connect (OSTI)

    Zhang, Lei; Reynolds, Kellie S.; Zhao, Ping; Huang, Shiew-Mei

    2010-03-01

    Pharmacokinetic drug interactions can lead to serious adverse events or decreased drug efficacy. The evaluation of a new molecular entity's (NME's) drug-drug interaction potential is an integral part of risk assessment during drug development and regulatory review. Alteration of activities of enzymes or transporters involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by concomitant drugs may alter drug exposure, which can impact response (safety or efficacy). The recent Food and Drug Administration (FDA) draft drug interaction guidance ( (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072101.pdf)) highlights the methodologies and criteria that may be used to guide drug interaction evaluation by industry and regulatory agencies and to construct informative labeling for health practitioner and patients. In addition, the Food and Drug Administration established a 'Drug Development and Drug Interactions' website to provide up-to-date information regarding evaluation of drug interactions ( (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm080499.htm)). This review summarizes key elements in the FDA drug interaction guidance and new scientific developments that can guide the evaluation of drug-drug interactions during the drug development process.

  8. Sandia, UCLA develop screening libraries to discover drug targets...

    National Nuclear Security Administration (NNSA)

    As headlines highlight the threat of viruses like Ebola and Zika, researchers at Sandia National Laboratories and the University of California Los Angeles (UCLA) have teamed up to ...

  9. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    can give rise to chromosome breaks, which in turn can lead to genome instabilities and cell death. The topo II enzyme performs this unraveling for DNA in the cell. Antibacterial...

  10. Electrically charged targets

    DOE Patents [OSTI]

    Goodman, Ronald K.; Hunt, Angus L.

    1984-01-01

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  11. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, Roy J.

    1986-01-01

    A polarized internal target apparatus with a polarized gas target of improved polarization and density achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms.

  12. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, R.J.

    1984-10-10

    A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

  13. Key Actions for Optimizing for KNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Actions for Optimizing for KNL Key Actions for Optimizing for KNL This webinar consisted of a presentation by Nathan Wichmann of Cray entitled, "Key Actions When Optimizing for KNL." Nathan is a Principal Performance Engineer responsible for tackling performance problems at Cray for many years and he is our contact for the NERSC/Cray Cori Applications Center of Excellence. Nathan's presentation results, in part, from his participation in several "brainstorming" telecons

  14. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Takeda Advances Diabetes Drug Development at the ALS Print Tuesday, 19 May 2015 12:25 Type 2 diabetes mellitus (T2DM), characterized by abnormally high blood glucose levels, affects hundreds of millions of people worldwide. In the pursuit to better treat this disease, the human receptor protein GPR40 has been identified by pharmaceutical company Takeda as a potential new drug target. To this end, TAK-875 (fasiglifam), a partial agonist of

  15. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print Tuesday, 23 June 2015 13:00 The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell

  16. Schedules of Key Environmental Impact Statements

    Broader source: Energy.gov [DOE]

    This document graphically displays the milestone dates and projected schedules of key Environmental Impact Statements (updated monthly). This chart represents anticipated activity and is not a...

  17. Florida Keys Electric Cooperative- Residential Rebate Program

    Broader source: Energy.gov [DOE]

    Note: The Florida Keys Electric Cooperative rebates were depleted in June of 2015. According to the website, rebates will be offered again dependent upon future funding.

  18. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS researchers have recently discovered a surprising key event in this energy-quenching process. Photoprotection Through Shifting Pigments Through photosynthesis, plants are able...

  19. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in ... diseases affecting the brain and its ability to make new connections and recall memories. ...

  20. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases...

  1. Magnetically attached sputter targets

    DOE Patents [OSTI]

    Makowiecki, D.M.; McKernan, M.A.

    1994-02-15

    An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

  2. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - Scientific Applications Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Lead ...

  3. High Power Cryogenic Targets

    SciTech Connect (OSTI)

    Gregory Smith

    2011-08-01

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  4. Captured key electrical safety lockout system

    DOE Patents [OSTI]

    Darimont, Daniel E. (Aurora, IL)

    1995-01-01

    A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member's second position corresponds to the preselected position at which the key can be removed from and inserted into the lock.

  5. Captured key electrical safety lockout system

    DOE Patents [OSTI]

    Darimont, D.E.

    1995-10-31

    A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member`s second position corresponds to the preselected position at which the key can be removed from and inserted into the lock. 7 figs.

  6. PARKING KEY: State Handicap Medically Permitted

    National Nuclear Security Administration (NNSA)

    PARKING KEY: State Handicap Medically Permitted Preferred (LEED) Visitor Motorcycle New Parking Spots / Parallel Parking NATIONAL SECURITY CAMPUS The DOE's National Security Campus is managed and operated by Honeywell. REVISED: August 2014

  7. Light Sources Help Discover New Drug Against Melanoma | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma July 18, 2011 - 12:07pm Addthis The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four

  8. Understanding the Key to Henipavirus Infection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Understanding the Key to Henipavirus Infection Understanding the Key to Henipavirus Infection Print Wednesday, 15 June 2016 00:00 In 1994, a virus emerged in Hendra, Australia, causing respiratory and neurological diseases. It was transmissible from horses to humans, with a mortality rate of 57% in humans and 89% in horses. In 1999, a similar virus, transmitted through domesticated pigs, caused over 100 human deaths in Sungai Nipah, a Malaysian village. The Hendra and Nipah viruses are

  9. Explosives performance key to stockpile stewardship

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Explosives performance key to stockpile stewardship Explosives performance key to stockpile stewardship A new video shows how researchers use scientific guns to induce shock waves into explosive materials to study their performance and properties. November 3, 2014 Adam Pacheco of shock and detonation physics presses the "fire" button during an experiment at the two-stage gas gun facility. Adam Pacheco of shock and detonation physics presses the "fire" button during an

  10. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Print Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS researchers have recently discovered a surprising key event in this energy-quenching

  11. Explosives performance key to stockpile stewardship

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Explosives performance key to stockpile stewardship Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Explosives performance key to stockpile stewardship A new video shows how researchers use scientific guns to induce shock waves into explosive materials to study their performance and properties January 1, 2015 Adam Pacheco of shock and detonation physics presses the "fire" button during an experiment at the

  12. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Brain Receptor Structures Key to Future Therapeutics Print Wednesday, 28 January 2015 00:00 With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function.

  13. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Print Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS researchers have recently discovered a surprising key event in this energy-quenching

  14. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Print Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS researchers have recently discovered a surprising key event in this energy-quenching

  15. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Print Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS researchers have recently discovered a surprising key event in this energy-quenching

  16. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Carotenoid Pigment is the Key to Photoprotection Print Wednesday, 30 September 2015 00:00 Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS

  17. 'Thirsty' Metals Key to Longer Battery Lifetimes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    'Thirsty' Metals Key to Longer Battery Lifetimes 'Thirsty' Metals Key to Longer Battery Lifetimes Computations at NERSC show how multiply charged metal ions impact battery capacity June 30, 2014 Contact: Kathy Kincade, +1 510 495 2124, kkincade@lbl.gov PCCPxantheascover Imagine a cell phone battery that lasted a whole week on a single charge. A car battery that worked for months between charges. A massive battery that stores the intermittent electricity from wind turbines and releases it when

  18. Bar coded retroreflective target

    DOE Patents [OSTI]

    Vann, Charles S.

    2000-01-01

    This small, inexpensive, non-contact laser sensor can detect the location of a retroreflective target in a relatively large volume and up to six degrees of position. The tracker's laser beam is formed into a plane of light which is swept across the space of interest. When the beam illuminates the retroreflector, some of the light returns to the tracker. The intensity, angle, and time of the return beam is measured to calculate the three dimensional location of the target. With three retroreflectors on the target, the locations of three points on the target are measured, enabling the calculation of all six degrees of target position. Until now, devices for three-dimensional tracking of objects in a large volume have been heavy, large, and very expensive. Because of the simplicity and unique characteristics of this tracker, it is capable of three-dimensional tracking of one to several objects in a large volume, yet it is compact, light-weight, and relatively inexpensive. Alternatively, a tracker produces a diverging laser beam which is directed towards a fixed position, and senses when a retroreflective target enters the fixed field of view. An optically bar coded target can be read by the tracker to provide information about the target. The target can be formed of a ball lens with a bar code on one end. As the target moves through the field, the ball lens causes the laser beam to scan across the bar code.

  19. TEC Working Group Topic Groups Rail Key Documents | Department...

    Office of Environmental Management (EM)

    Rail Key Documents TEC Working Group Topic Groups Rail Key Documents KEY DOCUMENTS Radiation Monitoring Subgroup Intermodal Subgroup Planning Subgroup Current FRA State Rail Safety ...

  20. TEC Working Group Topic Groups Section 180(c) Key Documents ...

    Office of Environmental Management (EM)

    Key Documents TEC Working Group Topic Groups Section 180(c) Key Documents Key Documents Briefing Package for Section 180(c) Implementation - July 2005 PDF icon Executive Summary...

  1. 2015 Key Water Power Program and National Laboratory Accomplishments...

    Energy Savers [EERE]

    2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power ...

  2. Key Activities in Energy Efficiency | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    About Key Activities in Energy Efficiency Key Activities in Energy Efficiency The Building Technologies Office conducts work in three key areas in order to continually develop ...

  3. HYDROGEN ISOTOPE TARGETS

    DOE Patents [OSTI]

    Ashley, R.W.

    1958-08-12

    The design of targets for use in the investigation of nuclear reactions of hydrogen isotopes by bombardment with accelerated particles is described. The target con struction eomprises a backing disc of a metal selected from the group consisting of molybdenunn and tungsten, a eoating of condensed titaniunn on the dise, and a hydrogen isotope selected from the group consisting of deuterium and tritium absorbed in the coatiag. The proeess for preparing these hydrogen isotope targets is described.

  4. Cellulosic Ethanol Cost Target

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Plenary Talk May 21, 2013 Cellulosic Ethanol Cost Target 2 | Biomass Program ... "Our goal is to make cellulosic ethanol practical and cost competitive within 6 ...

  5. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Target 2 Target 2 is housed in the Blue Room in MPF-7 at LANSCE and provides experimenters direct access to the LANSCE proton beam. The Blue Room is a domed room with a diameter of 40 feet. The main floor of the Blue Room is constructed primarily of aluminum and elevated 20 feet above the basement floor to minimize neutron wall return for

  6. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R.; Campbell, Heather L.; Da Silva, Luiz

    2002-01-01

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  7. Public key infrastructure for DOE security research

    SciTech Connect (OSTI)

    Aiken, R.; Foster, I.; Johnston, W.E.

    1997-06-01

    This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

  8. NIF Target Shot Metrics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    target shot metrics NIF Target Shot Metrics Exp Cap - Experimental Capability Natl Sec Appl - National Security Applications DS - Discovery Science ICF - Inertial Confinement Fusion HED - High Energy Density For internal LLNL firewall viewing - if the page is blank, please open www.google.com to flush out BCB

  9. Rab proteins: The key regulators of intracellular vesicle transport

    SciTech Connect (OSTI)

    Bhuin, Tanmay; Roy, Jagat Kumar

    2014-10-15

    Vesicular/membrane trafficking essentially regulates the compartmentalization and abundance of proteins within the cells and contributes in many signalling pathways. This membrane transport in eukaryotic cells is a complex process regulated by a large and diverse array of proteins. A large group of monomeric small GTPases; the Rabs are essential components of this membrane trafficking route. Most of the Rabs are ubiquitously expressed proteins and have been implicated in vesicle formation, vesicle motility/delivery along cytoskeleton elements and docking/fusion at target membranes through the recruitment of effectors. Functional impairments of Rabs affecting transport pathways manifest different diseases. Rab functions are accompanied by cyclical activation and inactivation of GTP-bound and GDP-bound forms between the cytosol and membranes which is regulated by upstream regulators. Rab proteins are characterized by their distinct sub-cellular localization and regulate a wide variety of endocytic, transcytic and exocytic transport pathways. Mutations of Rabs affect cell growth, motility and other biological processes. - Highlights: Rab proteins regulate different signalling pathways. Deregulation of Rabs is the fundamental causes of a variety of human diseases. This paper gives potential directions in developing therapeutic targets. This paper also gives ample directions for modulating pathways central to normal physiology. These are the huge challenges for drug discovery and delivery in near future.

  10. Key Management Challenges in Smart Grid

    SciTech Connect (OSTI)

    Sheldon, Frederick T; Duren, Mike

    2012-01-01

    Agenda Awarded in February 2011 Team of industry and research organizations Project Objectives Address difficult issues Complexity Diversity of systems Scale Longevity of solution Participate in standards efforts and working groups Develop innovative key management solutions Modeling and simulation ORNL Cyber Security Econometric Enterprise System Demonstrate effectiveness of solution Demonstrate scalability

  11. Automated Proactive Fault Isolation: A Key to Automated Commissioning

    SciTech Connect (OSTI)

    Katipamula, Srinivas; Brambley, Michael R.

    2007-07-31

    In this paper, we present a generic model for automated continuous commissioing and then delve in detail into one of the processes, proactive testing for fault isolation, which is key to automating commissioning. The automated commissioining process uses passive observation-based fault detction and diagnostic techniques, followed by automated proactive testing for fault isolation, automated fault evaluation, and automated reconfiguration of controls together to continuously keep equipment controlled and running as intended. Only when hard failures occur or a physical replacement is required does the process require human intervention, and then sufficient information is provided by the automated commissioning system to target manual maintenance where it is needed. We then focus on fault isolation by presenting detailed logic that can be used to automatically isolate faults in valves, a common component in HVAC systems, as an example of how automated proactive fault isolation can be accomplished. We conclude the paper with a discussion of how this approach to isolating faults can be applied to other common HVAC components and their automated commmissioning and a summary of key conclusions of the paper.

  12. An Unusual Mechanism for the Antimicrobial Target Flavine-dependant

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Thymidylate Synthase (FTDS) An Unusual Mechanism for the Antimicrobial Target Flavine-dependant Thymidylate Synthase (FTDS) Classical thymidylate synthases, encoded by the thyA and TYMS genes, are present in most eukaryotes, including humans, and are frequently targeted by chemotherapeutic and antibiotic drugs. A recently discovered class of thymidylate synthases, the FDTSs encoded by the thyX gene has been found primarily in prokaryotes and viruses including several pathogens and biological

  13. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

    SciTech Connect (OSTI)

    Hast, Michael A.; Nichols, Connie B.; Armstrong, Stephanie M.; Kelly, Shannon M.; Hellinga, Homme W.; Alspaugh, J. Andrew; Beese, Lorena S.

    2012-09-17

    Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals, including AIDS patients and transplant recipients. Few antifungals can treat C. neoformans infections, and drug resistance is increasing. Protein farnesyltransferase (FTase) catalyzes post-translational lipidation of key signal transduction proteins and is essential in C. neoformans. We present a multidisciplinary study validating C. neoformans FTase (CnFTase) as a drug target, showing that several anticancer FTase inhibitors with disparate scaffolds can inhibit C. neoformans and suggesting structure-based strategies for further optimization of these leads. Structural studies are an essential element for species-specific inhibitor development strategies by revealing similarities and differences between pathogen and host orthologs that can be exploited. We, therefore, present eight crystal structures of CnFTase that define the enzymatic reaction cycle, basis of ligand selection, and structurally divergent regions of the active site. Crystal structures of clinically important anticancer FTase inhibitors in complex with CnFTase reveal opportunities for optimization of selectivity for the fungal enzyme by modifying functional groups that interact with structurally diverse regions. A substrate-induced conformational change in CnFTase is observed as part of the reaction cycle, a feature that is mechanistically distinct from human FTase. Our combined structural and functional studies provide a framework for developing FTase inhibitors to treat invasive fungal infections.

  14. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Print Type 2 diabetes mellitus (T2DM), characterized by abnormally high blood glucose levels, affects hundreds of millions of people worldwide. In the pursuit to better treat this disease, the human receptor protein GPR40 has been identified by pharmaceutical company Takeda as a potential new drug target. To this end, TAK-875 (fasiglifam), a partial agonist of GPR40, was brought into clinical development by Takeda as a possible new treatment

  15. Computer modeling reveals how surprisingly potent hepatitis C drug works

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy

  16. Multiple shell fusion targets

    DOE Patents [OSTI]

    Lindl, J.D.; Bangerter, R.O.

    1975-10-31

    Multiple shell fusion targets for use with electron beam and ion beam implosion systems are described. The multiple shell targets are of the low-power type and use a separate relatively low Z, low density ablator at large radius for the outer shell, which reduces the focusing and power requirements of the implosion system while maintaining reasonable aspect ratios. The targets use a high Z, high density pusher shell placed at a much smaller radius in order to obtain an aspect ratio small enough to protect against fluid instability. Velocity multiplication between these shells further lowers the power requirements. Careful tuning of the power profile and intershell density results in a low entropy implosion which allows breakeven at low powers. For example, with ion beams as a power source, breakeven at 10-20 Terrawatts with 10 MeV alpha particles for imploding a multiple shell target can be accomplished.

  17. Drug Detection Study

    Office of Scientific and Technical Information (OSTI)

    ... cause a person to be identified as using that substance in a workplace drug test. The initial test refers to the screening assay on specimens to eliminate a "negative" result ...

  18. Diversity and Flexibility: Key to Sustainability

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Babson, Ph.D. Senior Engineer Union of Concerned Scientists Diversity & Flexibility Key to Sustainability Biofuels Pathways are Diverse * General perception of biofuels are limited to corn ethanol and soybean biodiesel Biofuels Pathways are Diverse * General perception of biofuels are limited to corn ethanol and soybean biodiesel * Biofuels are important and they are so much more than corn ethanol and soybean biodiesel Biofuels Pathways are Diverse * General perception of biofuels are

  19. Milling of key slots on long shafts

    SciTech Connect (OSTI)

    Agadzhanyan, R.A.; Bogdanenko, Yu.G.

    1987-03-01

    The authors look for and test methods and tool materials for milling key slots into rod pump shafts made of steel-03KH14N7V and K Monel alloy which not only increase the precision of the milling process but also extend the life of the milling tool. Their test parameters include various methods for introduction of the cutting fluid into the milling process, the effect of carbonitridation of the tool material, and the productivity of the machine itself.

  20. Identification of Key Barriers in Workforce Development

    SciTech Connect (OSTI)

    2008-03-31

    This report documents the identification of key barriers in the development of an adequate national security workforce as part of the National Security Preparedness Project, being performed under a Department of Energy/National Nuclear Security Administration grant. Many barriers exist that prevent the development of an adequate number of propertly trained national security personnel. Some barriers can be eliminated in a short-term manner, whereas others will involve a long-term strategy that takes into account public policy.

  1. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function. These molecules transmit signals between nerve cells and are critical to learning and

  2. Key Physical Mechanisms in Nanostructured Solar Cells

    SciTech Connect (OSTI)

    Dr Stephan Bremner

    2010-07-21

    The objective of the project was to study both theoretically and experimentally the excitation, recombination and transport properties required for nanostructured solar cells to deliver energy conversion efficiencies well in excess of conventional limits. These objectives were met by concentrating on three key areas, namely, investigation of physical mechanisms present in nanostructured solar cells, characterization of loss mechanisms in nanostructured solar cells and determining the properties required of nanostructured solar cells in order to achieve high efficiency and the design implications.

  3. Key Issues in Tribal Energy Development

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Issues in Tribal Energy Development Common Issues, Causes and Solutions Douglas C. MacCourt, Ater Wynne LLP Chair Chair, Executive Committee Indian Law Practice Group Indian Law Section Ater Wynne LLP Oregon State Bar Association dcm@aterwynne.com www.aterwynne.com US DOE Tribal Energy Program/NREL Denver, Colorado October 25-28, 2010 Overview of Presentation * Overview of Handbook * A note on Alaska * Common development issues and solutions 1. Finding Early Stage Risk Capital * Necessary

  4. Key Renewable Energy Opportunities for Oklahoma Tribes

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    KEY RENEWABLE ENERGY OPPORTUNITIES FOR OKLAHOMA TRIBES August 13, 2012 COX CONVENTION CENTER 100 West Sheridan Avenue, Oklahoma City, OK 73102 (405) 602-8500 The fifth in a series of planned U.S. DOE Office of Indian Energy-sponsored strategic energy development & investment forums, this forum is designed to give Oklahoma tribal leaders the opportunity to receive the latest updates on DOE's energy development efforts in Indian Country. The Forum will provide a venue for tribal leaders to

  5. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function. These molecules transmit signals between nerve cells and are critical to learning and

  6. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function. These molecules transmit signals between nerve cells and are critical to learning and

  7. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function. These molecules transmit signals between nerve cells and are critical to learning and

  8. New Security Results on Encrypted Key Exchange

    SciTech Connect (OSTI)

    Bresson, Emmanuel; Chevassut, Olivier; Pointcheval, David

    2003-12-15

    Schemes for encrypted key exchange are designed to provide two entities communicating over a public network, and sharing a (short) password only, with a session key to be used to achieve data integrity and/or message confidentiality. An example of a very efficient and ''elegant'' scheme for encrypted key exchange considered for standardization by the IEEE P1363 Standard working group is AuthA. This scheme was conjectured secure when the symmetric-encryption primitive is instantiated via either a cipher that closely behaves like an ''ideal cipher,'' or a mask generation function that is the product of the message with a hash of the password. While the security of this scheme in the former case has been recently proven, the latter case was still an open problem. For the first time we prove in this paper that this scheme is secure under the assumptions that the hash function closely behaves like a random oracle and that the computational Diffie-Hellman problem is difficult. Furthermore, since Denial-of-Service (DoS) attacks have become a common threat we enhance AuthA with a mechanism to protect against them.

  9. Drug Testing Notification | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Drug Testing Notification Drug Testing Notification PDF icon Drug Testing Notification More Documents & Publications Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, ...

  10. The Sinuous Target

    SciTech Connect (OSTI)

    Zwaska, R.

    2015-06-01

    We report on the concept for a target material comprised of a multitude of interlaced wires of small dimension. This target material concept is primarily directed at high-power neutrino targets where the thermal shock is large due to small beam sizes and short durations; it also has applications to other high-power targets, particularly where the energy deposition is great or a high surface area is preferred. This approach ameliorates the problem of thermal shock by engineering a material with high strength on the micro-scale, but a very low modulus of elasticity on the meso-scale. The low modulus of elasticity is achieved by constructing the material of spring-like wire segments much smaller than the beam dimension. The intrinsic bends of the wires will allow them to absorb the strain of thermal shock with minimal stress. Furthermore, the interlaced nature of the wires provides containment of any segment that might become loose. We will discuss the progress on studies of analogue materials and fabrication techniques for sinuous target materials.

  11. Production Target Design Report

    SciTech Connect (OSTI)

    Woloshun, Keith Albert; Dale, Gregory E.; Olivas, Eric Richard

    2015-07-28

    The Northstar 99Mo production target, a cylindrical length of 100Mo rod, has evolved considerably since its first conception.  The cylinder was very early sliced into disks to increase the heat transfer area, first to 1 mm thick disks then to the current 0.5 mm thick.  The coolant was changed early in the target development from water to helium to eliminate corrosion and dissolution.  The diameter has increased from initially 6 mm to 12 mm, the current diameter of the test target now at ANL, to nominally 28 mm (26-30.6 mm, depending upon optimal beam spot size and shape).  The length has also changed to improve the production to cost ratio, so now the target is nominally 41 mm long (excluding coolant gaps between disks), and irradiated on both ends.  This report summarizes the current status of the plant target design.

  12. CONSTRUCTION OF KEY CLEANUP PROJECT GAINS GOOD GROUND AT SRS...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    CONSTRUCTION OF KEY CLEANUP PROJECT GAINS GOOD GROUND AT SRS CONSTRUCTION OF KEY CLEANUP PROJECT GAINS GOOD GROUND AT SRS June 1, 2010 - 12:00pm Addthis CONSTRUCTION OF KEY CLEANUP ...

  13. Method for encryption and transmission of digital keying data

    DOE Patents [OSTI]

    Mniszewski, Susan M.; Springer, Edward A.; Brenner, David P.

    1988-01-01

    A method for the encryption, transmission, and subsequent decryption of digital keying data. The method utilizes the Data Encryption Standard and is implemented by means of a pair of apparatus, each of which is selectable to operate as either a master unit or remote unit. Each unit contains a set of key encryption keys which are indexed by a common indexing system. The master unit operates upon command from the remote unit to generate a data encryption key and encrypt the data encryption key using a preselected key encryption key. The encrypted data encryption key and an index designator are then downloaded to the remote unit, where the data encryption key is decrypted for subsequent use in the encryption and transmission data. Downloading of the encrypted data encryption key enables frequent change of keys without requiring manual entry or storage of keys at the remote unit.

  14. Cryptographic Key Management and Critical Risk Assessment

    SciTech Connect (OSTI)

    Abercrombie, Robert K

    2014-05-01

    The Department of Energy Office of Electricity Delivery and Energy Reliability (DOE-OE) CyberSecurity for Energy Delivery Systems (CSEDS) industry led program (DE-FOA-0000359) entitled "Innovation for Increasing CyberSecurity for Energy Delivery Systems (12CSEDS)," awarded a contract to Sypris Electronics LLC to develop a Cryptographic Key Management System for the smart grid (Scalable Key Management Solutions for Critical Infrastructure Protection). Oak Ridge National Laboratory (ORNL) and Sypris Electronics, LLC as a result of that award entered into a CRADA (NFE-11-03562) between ORNL and Sypris Electronics, LLC. ORNL provided its Cyber Security Econometrics System (CSES) as a tool to be modified and used as a metric to address risks and vulnerabilities in the management of cryptographic keys within the Advanced Metering Infrastructure (AMI) domain of the electric sector. ORNL concentrated our analysis on the AMI domain of which the National Electric Sector Cyber security Organization Resource (NESCOR) Working Group 1 (WG1) has documented 29 failure scenarios. The computational infrastructure of this metric involves system stakeholders, security requirements, system components and security threats. To compute this metric, we estimated the stakes that each stakeholder associates with each security requirement, as well as stochastic matrices that represent the probability of a threat to cause a component failure and the probability of a component failure to cause a security requirement violation. We applied this model to estimate the security of the AMI, by leveraging the recently established National Institute of Standards and Technology Interagency Report (NISTIR) 7628 guidelines for smart grid security and the International Electrotechnical Commission (IEC) 63351, Part 9 to identify the life cycle for cryptographic key management, resulting in a vector that assigned to each stakeholder an estimate of their average loss in terms of dollars per day of system

  15. Fermilab | Science | Particle Physics | Key Discoveries

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Discoveries Fermilab produced its first high-energy particle beam on March 1, 1972. Since then hundreds of experiments have used Fermilab's accelerators to study matter at ever smaller scales and its detectors to study the universe at great distances. Here an overview of the top achievements so far. Discovery of the Higgs boson Discovery of the top quark Discovery of the bottom quark Observation of tau neutrino Discovery of a quasar at a distance of 27 billion light-years Observation of

  16. Preliminary safety assessment for an IFE target fabrication facility

    SciTech Connect (OSTI)

    Latkowski, J F; Reyes, S; Besenbruch, G E; Goodin, D T

    2000-10-13

    We estimate possible ranges of tritium inventories for an inertial fusion energy (IFE) target fabrication facility producing various types of targets and using various production technologies. Target fill is the key subtask in determining the overall tritium inventory for the plant. By segmenting the inventory into multiple, parallel production lines--each with its own fill canister--and including an expansion tank to limit releases, we are able to ensure that a target fabrication facility would meet the accident dose goals of 10 mSv (1 rem) set forth in the Department of Energy's Fusion Safety Standards. For indirect-drive targets, we calculate release fractions for elements from lithium to bismuth and show that nearly all elements meet the dose goal. Our work suggests directions for future R&D that will help reduce total tritium inventories and increase the flexibility of target fabrication facilities.

  17. Cooled particle accelerator target

    DOE Patents [OSTI]

    Degtiarenko, Pavel V.

    2005-06-14

    A novel particle beam target comprising: a rotating target disc mounted on a retainer and thermally coupled to a first array of spaced-apart parallel plate fins that extend radially inwardly from the retainer and mesh without physical contact with a second array of spaced-apart parallel plate fins that extend radially outwardly from and are thermally coupled to a cooling mechanism capable of removing heat from said second array of spaced-apart fins and located within the first array of spaced-apart parallel fins. Radiant thermal exchange between the two arrays of parallel plate fins provides removal of heat from the rotating disc. A method of cooling the rotating target is also described.

  18. Foam encapsulated targets

    DOE Patents [OSTI]

    Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

    1983-01-01

    Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

  19. Targeted polypeptide degradation

    DOE Patents [OSTI]

    Church, George M.; Janse, Daniel M.

    2008-05-13

    This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

  20. Spotlight on Key Program Strategies from the Better Buildings...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Spotlight on Key Program Strategies from the Better Buildings Neighborhood Program, Final Evaluation Volume 6 Spotlight on Key Program Strategies from the Better Buildings Neighborhood ...

  1. Key Renewable Energy Opportunities for Oklahoma Tribes | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Renewable Energy Opportunities for Oklahoma Tribes Key Renewable Energy Opportunities for Oklahoma Tribes August 13, 2012 Oklahoma City, Oklahoma Cox Convention Center The...

  2. Turbulence may be key to "fast magnetic reconnection" mystery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Turbulence may be key to "fast magnetic reconnection" mystery Turbulence may be key to "fast magnetic reconnection" mystery The new research could lead to better understanding of ...

  3. Energy: Critical Infrastructure and Key Resources Sector-Specific...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy: Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) Energy: Critical Infrastructure and Key ...

  4. Energy Critical Infrastructure and Key Resources Sector-Specific...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) Energy Critical Infrastructure and Key ...

  5. Cooling Towers: Understanding Key Components of Cooling Towers...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve Water Efficiency Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve ...

  6. Keys to Successful Quality Assurance and Quality Control Programs...

    Office of Environmental Management (EM)

    Keys to Successful Quality Assurance and Quality Control Programs (101) Keys to Successful Quality Assurance and Quality Control Programs (101) January 28...

  7. Focus Series: Program Finds Community "Readiness" Is the Key...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Program Finds Community "Readiness" Is the Key to More Retrofits Focus Series: Program Finds Community "Readiness" Is the Key to More Retrofits Focus Series: Program Finds ...

  8. Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. ...

  9. Physicists in China Nail a Key Neutrino Measurement (Science...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in China Nail a Key Neutrino Measurement (Science) External Link: http:news.sciencemag.orgsciencenow201203physicists-in-china-nail-a-key.htm... By jlabadmin on Thu, ...

  10. Building America Expert Meeting: Key Innovations for Adding Energy...

    Energy Savers [EERE]

    Key Innovations for Adding Energy Efficiency to Maintenance Projects Building America Expert Meeting: Key Innovations for Adding Energy Efficiency to Maintenance Projects This ...

  11. Self-Referenced Continuous-Variable Quantum Key Distribution...

    Office of Scientific and Technical Information (OSTI)

    Self-Referenced Continuous-Variable Quantum Key Distribution Protocol Citation Details In-Document Search Title: Self-Referenced Continuous-Variable Quantum Key Distribution ...

  12. Keys to Successful Quality Assurance and Quality Control Programs...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Keys to Successful Quality Assurance and Quality Control Programs (101) Keys to Successful Quality Assurance and Quality Control Programs (101) Better Buildings Residential Network ...

  13. PEM Fuel Cell Technology, Key Research Needs and Approaches ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Technology, Key Research Needs and Approaches (Presentation) PEM Fuel Cell Technology, Key Research Needs and Approaches (Presentation) Presented at the DOE Fuel Cell ...

  14. Together with Key Allies, DOE Launches New Data Collaborative...

    Energy Savers [EERE]

    Together with Key Allies, DOE Launches New Data Collaborative to Help Cities and States Advance Building Efficiency Together with Key Allies, DOE Launches New Data Collaborative to ...

  15. 2015 Key Water Power Program and National Laboratory Accomplishments...

    Broader source: Energy.gov (indexed) [DOE]

    Water Power Program and National Laboratory Accomplishments 2015 Key Water Power Program and National Laboratory Accomplishments | 1 | 2015 Key Water Power Program and National ...

  16. Targeted radionuclide therapy

    SciTech Connect (OSTI)

    Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F.

    2008-07-15

    Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

  17. Low-Power Public Key Cryptography

    SciTech Connect (OSTI)

    BEAVER,CHERYL L.; DRAELOS,TIMOTHY J.; HAMILTON,VICTORIA A.; SCHROEPPEL,RICHARD C.; GONZALES,RITA A.; MILLER,RUSSELL D.; THOMAS,EDWARD V.

    2000-11-01

    This report presents research on public key, digital signature algorithms for cryptographic authentication in low-powered, low-computation environments. We assessed algorithms for suitability based on their signature size, and computation and storage requirements. We evaluated a variety of general purpose and special purpose computing platforms to address issues such as memory, voltage requirements, and special functionality for low-powered applications. In addition, we examined custom design platforms. We found that a custom design offers the most flexibility and can be optimized for specific algorithms. Furthermore, the entire platform can exist on a single Application Specific Integrated Circuit (ASIC) or can be integrated with commercially available components to produce the desired computing platform.

  18. Drug development and manufacturing

    DOE Patents [OSTI]

    Warner, Benjamin P.; McCleskey, T. Mark; Burrell, Anthony K.

    2015-10-13

    X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.

  19. SECTION L -ATTACHMENT B - LISTING OF KEY PERSONNEL

    National Nuclear Security Administration (NNSA)

    H SECTION J APPENDIX H KEY PERSONNEL [Note: To be inserted by the Contracting Officer after

  20. Climate Action Planning: A Review of Best Practices, Key Elements...

    Open Energy Info (EERE)

    a climate action plan. The report includes detailed discussion of stakeholder involvement, establishing a target date and interim targets for achieving climate neutrality,...

  1. NASA agreements advance Mars exploration, Los Alamos Rover instrument a key

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    component NASA agreements advance Mars exploration NASA agreements advance Mars exploration, Los Alamos Rover instrument a key component Los Alamos National Laboratory is coordinating with the French science and engineering team on developing SuperCam. June 17, 2015 SuperCam builds upon the successful capabilities demonstrated by ChemCam aboard the Curiosity Rover during NASA's current Mars Mission. SuperCam will allow researchers to sample rocks and other targets from a distance using a

  2. Solvent recovery targeting

    SciTech Connect (OSTI)

    Ahmad, B.S.; Barton, P.I.

    1999-02-01

    One of the environmental challenges faced by the pharmaceutical and specialty chemical industries is the widespread use of organic solvents. With a solvent-based chemistry, the solvent necessarily has to be separated from the product. Chemical species in waste-solvent streams typically form multicomponent azeotropic mixtures, and this often complicates separation and, hence, recovery of solvents. A design approach is presented whereby process modifications proposed by the engineer to reduce the formation of waste-solvent streams can be evaluated systematically. This approach, called solvent recovery targeting, exploits a recently developed algorithm for elucidating the separation alternatives achievable when applying batch distillation to homogeneous multicomponent mixtures. The approach places the composition of the waste-solvent mixture correctly in the relevant residue curve map and computes the maximum amount of pure material that can be recovered via batch distillation. Solvent recovery targeting is applied to two case studies derived from real industrial processes.

  3. Method for forming targets

    DOE Patents [OSTI]

    Woerner, Robert L.

    1979-01-01

    Method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

  4. Apparatus for forming targets

    DOE Patents [OSTI]

    Woerner, Robert L.

    1980-01-01

    Apparatus and method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

  5. Key management for large scale end-to-end encryption

    SciTech Connect (OSTI)

    Witzke, E.L.

    1994-07-01

    Symmetric end-to-end encryption requires separate keys for each pair of communicating confidants. This is a problem of Order N{sup 2}. Other factors, such as multiple sessions per pair of confidants and multiple encryption points in the ISO Reference Model complicate key management by linear factors. Public-key encryption can reduce the number of keys managed to a linear problem which is good for scaleability of key management, but comes with complicating issues and performance penalties. Authenticity is the primary ingredient of key management. If each potential pair of communicating confidants can authenticate data from each other, then any number of public encryption keys of any type can be communicated with requisite integrity. These public encryption keys can be used with the corresponding private keys to exchange symmetric cryptovariables for high data rate privacy protection. The Digital Signature Standard (DSS), which has been adopted by the United States Government, has both public and private components, similar to a public-key cryptosystem. The Digital Signature Algorithm of the DSS is intended for authenticity but not for secrecy. In this paper, the authors will show how the use of the Digital Signature Algorithm combined with both symmetric and asymmetric (public-key) encryption techniques can provide a practical solution to key management scaleability problems, by reducing the key management complexity to a problem of order N, without sacrificing the encryption speed necessary to operate in high performance networks.

  6. Florida Keys El Coop Assn, Inc | Open Energy Information

    Open Energy Info (EERE)

    Keys El Coop Assn, Inc Jump to: navigation, search Name: Florida Keys El Coop Assn, Inc Place: Florida Phone Number: 305-852-2431 Website: www.fkec.com Twitter: @FLKeysElectric...

  7. Solid Electrolyte: the Key for High-Voltage Lithium Batteries...

    Office of Scientific and Technical Information (OSTI)

    Solid Electrolyte: the Key for High-Voltage Lithium Batteries Citation Details In-Document Search Title: Solid Electrolyte: the Key for High-Voltage Lithium Batteries Authors: Li, ...

  8. Target: Subpoena (2010-SE-2001)

    Broader source: Energy.gov [DOE]

    DOE issued a Subpoena for Information and Production of Documents to Target Corporation requesting information regarding the compliance of various torchieres Target has distributed in commerce in the U.S.

  9. Fuel Cell Technologies Office Key Activities | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    About the Fuel Cell Technologies Office » Fuel Cell Technologies Office Key Activities Fuel Cell Technologies Office Key Activities The Fuel Cell Technologies Office conducts work in several key areas to advance the development and commercialization of hydrogen and fuel cell technologies. Research, Development, and Demonstration Key areas of research, development, and demonstration (RD&D) include the following: Fuel Cell R&D, which seeks to improve the durability, reduce the cost, and

  10. Key Dates | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Key Dates DOE Office of Science Graduate Student Research (SCGSR) Program SCGSR Home Eligibility Benefits Participant Obligations How to Apply Information for Laboratory Scientists and Thesis Advisors Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A FeedbackShare Page The SCGSR Program Key Dates are noted below. At the submission deadline (shown in red), the online application system will close after which no additional materials will be accepted. The

  11. June2010KeyEISChart.pdf | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    June2010KeyEISChart.pdf June2010KeyEISChart.pdf June2010KeyEISChart.pdf (59.25 KB) More Documents & Publications Schedules of Key Environmental Impact Statements Demonstration of a Variable Phase Turbine Power System for Low Temperature Geothermal Resources A 3D-3C Reflection Seismic Survey and Data Integration to Identify the Seismic Response of Fractures and Permeable Zones Over a Known Geothermal Resource at Soda Lake, Churchhill Co., NV

  12. Residential Energy Efficiency Financing: Key Elements of Program Design

    Broader source: Energy.gov [DOE]

    Presents key programmatic elements and context of financing initiatives, including contractor support, rebates, quality assurance, and more.

  13. 2015 Key Water Power Program and National Laboratory Accomplishments

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Slideshow | Department of Energy 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow Addthis 2015 Key Water Power Program and National Laboratory Accomplishments Report 1 of 28 2015 Key Water Power Program and National Laboratory Accomplishments Report By accelerating the development of markets for hydropower and marine and hydrokinetic (MHK) projects, the Water Power Program is striving

  14. 2015 Key Wind Program and National Laboratory Accomplishments Slideshow |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 2015 Key Wind Program and National Laboratory Accomplishments Slideshow 2015 Key Wind Program and National Laboratory Accomplishments Slideshow Addthis 2015 Key Wind Program and National Laboratory Accomplishments 1 of 32 2015 Key Wind Program and National Laboratory Accomplishments The U.S. Department of Energy (DOE) Wind Program is committed to helping the nation secure cost-competitive sources of renewable energy through the development and deployment of innovative

  15. 2015 Key Water Power Program and National Laboratory Accomplishments

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Slideshow | Department of Energy 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power Program and National Laboratory Accomplishments Report 1 of 28 2015 Key Water Power Program and National Laboratory Accomplishments Report By accelerating the development of markets for hydropower and marine and hydrokinetic (MHK) projects, the Water Power Program is striving to

  16. 2015 Key Wind Program and National Laboratory Accomplishments | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 2015 Key Wind Program and National Laboratory Accomplishments 2015 Key Wind Program and National Laboratory Accomplishments 2015 Key Wind Program and National Laboratory Accomplishments 1 of 32 2015 Key Wind Program and National Laboratory Accomplishments The U.S. Department of Energy (DOE) Wind Program is committed to helping the nation secure cost-competitive sources of renewable energy through the development and deployment of innovative wind power technologies. By investing in

  17. Key Dates | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Dates Albert Einstein Distinguished Educator Fellowship (AEF) Program Einstein Fellowship Home Eligibility Benefits Obligations How to Apply Key Dates Frequently Asked Questions Fellows Central Contact WDTS Home Key Dates Print Text Size: A A A FeedbackShare Page Key Dates for the 2017-2018 AEF Program Application process. On-line Application Opens August 17, 2016 Application Deadline 8:00pm EST November 17, 2016 Application Review 8 - 9 weeks Notification to Semi-Finalists [Travel

  18. Key Dates | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Dates DOE Office of Science Graduate Student Research (SCGSR) Program SCGSR Home Eligibility Benefits Participant Obligations How to Apply Information for Laboratory Scientists and Thesis Advisors Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A FeedbackShare Page The SCGSR Program Key Dates are noted below. At the submission deadline (shown in red), the online application system will close after which no additional materials will be accepted. The

  19. SECTION L -ATTACHMENT B - LISTING OF KEY PERSONNEL

    National Nuclear Security Administration (NNSA)

    B, Page 1 SECTION L ATTACHMENT B LISTING OF KEY PERSONNEL TITLE NAME Note: Addremove extra rows if needed...

  20. Key Activities of the Geothermal Technologies Office | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    About the Geothermal Technologies Office » Key Activities of the Geothermal Technologies Office Key Activities of the Geothermal Technologies Office Key activities for the Geothermal Technologies Office (GTO) include research, development and demonstration; system validation; technology validation; strategic planning, analysis, and R&D integration. Specific activities are summarized below. Program Area Activities Enhanced Geothermal Systems (EGS) GTO conducts research, development and

  1. Electromagnetic targeting of guns

    SciTech Connect (OSTI)

    Pogue, E.W.; Boat, R.M.; Holden, D.N.; Lopez, J.R.

    1996-10-01

    This is the final report of a one-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Electromagnetic pulse (EMP) signals produced from explosives being fired have been reported in the literature for fifty years. When a gun is fired it produces an EMP muzzle blast signal. The strength and nature of these signals was first analyzed in the early 1970s, while the results were interesting, no follow-up studies were conducted. With modern detection and signal processing technology, we believe that these signals could be used to instantaneously locate guns of virtually all calibers as they fire. The objective of our one-year project was to establish the basic nature of these signals and their utility in the concept of electromagnetic targeting of guns.

  2. Target detection portal

    DOE Patents [OSTI]

    Linker, Kevin L.; Brusseau, Charles A.

    2002-01-01

    A portal apparatus for screening persons or objects for the presence of trace amounts of target substances such as explosives, narcotics, radioactive materials, and certain chemical materials. The portal apparatus can have a one-sided exhaust for an exhaust stream, an interior wall configuration with a concave-shape across a horizontal cross-section for each of two facing sides to result in improved airflow and reduced washout relative to a configuration with substantially flat parallel sides; air curtains to reduce washout; ionizing sprays to collect particles bound by static forces, as well as gas jet nozzles to dislodge particles bound by adhesion to the screened person or object. The portal apparatus can be included in a detection system with a preconcentrator and a detector.

  3. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    structural similarities between SalL and flurorinase could lead to new halogenation pathways and more effective drug treatment strategies. Closeup view of SalL's...

  4. Liquid film target impingement scrubber

    DOE Patents [OSTI]

    McDowell, William J.; Coleman, Charles F.

    1977-03-15

    An improved liquid film impingement scrubber is provided wherein particulates suspended in a gas are removed by jetting the particle-containing gas onto a relatively small thin liquid layer impingement target surface. The impingement target is in the form of a porous material which allows a suitable contacting liquid from a pressurized chamber to exude therethrough to form a thin liquid film target surface. The gas-supported particles collected by impingement of the gas on the target are continuously removed and flushed from the system by the liquid flow through each of a number of pores in the target.

  5. Drug Testing for DOE Positions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing Matrix Secretary Bodman's Memorandum Regarding Drug Testing at DOE Fact ...

  6. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hosoya, Hitomi; Dobroff, Andrey S.; Driessen, Wouter H. P.; Cristini, Vittorio; Brinker, Lina M.; Staquicini, Fernanda I.; Cardó-Vila, Marina; D’Angelo, Sara; Ferrara, Fortunato; Proneth, Bettina; et al

    2016-02-02

    A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogel-based nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared,more » thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. We conclude that these results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications.« less

  7. Enterprise Assessments Targeted Review of the Targeted Review...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    assessment, conducted in August 2014, was part of a larger targeted assessment of safety class and safety significant structures, systems, and components across the DOE complex. ...

  8. National Rotor Testbed Targets Future Wind Plant Research Needs |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Rotor Testbed Targets Future Wind Plant Research Needs National Rotor Testbed Targets Future Wind Plant Research Needs May 18, 2015 - 4:12pm Addthis Two illustrated graphs. The graph on the top shows a single line repeating in four quadrants, the bottom graph shows all colors The U.S. Department of Energy's (DOE's) Atmosphere to Electrons (A2e) initiative has identified the evolution of wakes in turbulent inflow as a key physical process affecting power production and

  9. Facility target insert shielding assessment

    SciTech Connect (OSTI)

    Mocko, Michal

    2015-10-06

    Main objective of this report is to assess the basic shielding requirements for the vertical target insert and retrieval port. We used the baseline design for the vertical target insert in our calculations. The insert sits in the 12”-diameter cylindrical shaft extending from the service alley in the top floor of the facility all the way down to the target location. The target retrieval mechanism is a long rod with the target assembly attached and running the entire length of the vertical shaft. The insert also houses the helium cooling supply and return lines each with 2” diameter. In the present study we focused on calculating the neutron and photon dose rate fields on top of the target insert/retrieval mechanism in the service alley. Additionally, we studied a few prototypical configurations of the shielding layers in the vertical insert as well as on the top.

  10. A key management concept for the CTBT International Monitoring System

    SciTech Connect (OSTI)

    Herrington, P.; Draelos, T.; Craft, R.; Brickell, E.; Frankel, Y.; Silvestri, M.

    1997-08-01

    Cryptographic authentication (commonly referred to as ``technical authentication`` in Working Group B) is an enabling technology which ensures the integrity of sensor data and security of digital networks under various data security compromise scenarios. The use of cryptographic authentication,however, implies the development of a key management infrastructure for establishing trust in the generation and distribution of cryptographic keys. This paper proposes security and operational requirements for a CTBT (Comprehensive Test Ban Treaty) key management system and, furthermore, presents a public key based solution satisfying the requirements. The key management system is instantiated with trust distribution technologies similar to those currently implemented in industrial public key infrastructures. A complete system solution is developed.

  11. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, D.N.

    1996-01-09

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

  12. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, Douglas N.

    1996-01-01

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

  13. Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Across U.S. Industry | Department of Energy Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry eip_report_pg9.pdf (2.52 MB) More Documents & Publications ITP Energy Intensive Processes: Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry Energy Technology Solutions Energy Technology Solutions: Public-Private

  14. Key Renewable Energy Opportunities for Oklahoma Tribes | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Key Renewable Energy Opportunities for Oklahoma Tribes Key Renewable Energy Opportunities for Oklahoma Tribes August 13, 2012 Oklahoma City, Oklahoma Cox Convention Center The Office of Indian Energy Tribal Leader Energy Forum on Key Renewable Energy Opportunities for Oklahoma Tribes was held August 13, 2012, in Oklahoma City, Oklahoma. The forum gave Oklahoma tribal leaders the opportunity to receive the latest updates on DOE's energy development efforts in Indian Country and

  15. Keys to Successful Quality Assurance and Quality Control Programs (101) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Keys to Successful Quality Assurance and Quality Control Programs (101) Keys to Successful Quality Assurance and Quality Control Programs (101) Better Buildings Residential Network Peer Exchange Call Series: Keys to Successful Quality Assurance and Quality Control Programs (101), call slides and discussion summary. Call Slides and Discussion Summary (1.79 MB) More Documents & Publications Quality Control, Standardization of Upgrades, and Workforce Expectations Home

  16. 2015 Key Wind Program and National Laboratory Accomplishments | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 5 Key Wind Program and National Laboratory Accomplishments 2015 Key Wind Program and National Laboratory Accomplishments 2015 Key Wind Program and National Laboratory Accomplishments The U.S. Department of Energy (DOE) Wind Program is committed to helping the nation secure cost-competitive sources of renewable energy through the development and deployment of innovative wind power technologies. By investing in improvements to wind plant design, technology development, and operation

  17. DOE Announces More Key Administration Posts | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Key Administration Posts DOE Announces More Key Administration Posts March 27, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Ray Mabus, Secretary of the Navy, Department of Defense; Donald Remy, General Counsel of the Army, Department of Defense; J. Randolph Babbitt, Administrator, Federal Aviation Administration; Jose D. Riojas, Assistant Secretary for Operations, Security and

  18. Vehicle Technologies Office: Key Activities in Vehicles | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy About the Vehicle Technologies Office » Vehicle Technologies Office: Key Activities in Vehicles Vehicle Technologies Office: Key Activities in Vehicles We conduct work in four key areas to develop and deploy vehicle technologies that reduce the use of petroleum while maintaining or improving performance, power, and comfort. Research and development (R&D); testing and analysis; government and community stakeholder support; and education help people access and use efficient, clean

  19. Hydrodynamic experiment provides key data for Stockpile Stewardship

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hydrodynamic experiment provides Stockpile Stewardship key data Los Alamos hydrodynamic experiment provides key data for Stockpile Stewardship Hydrodynamic experiments such as Leda involve non-nuclear surrogate materials that mimic many of the properties of nuclear materials. December 22, 2014 Los Alamos hydrodynamic experiment provides key data for Stockpile Stewardship "Leda," experimental vessel in the "Zero Room" at the underground U1a facility, at the Nevada National

  20. TEC Working Group Topic Groups Security Key Documents | Department of

    Office of Environmental Management (EM)

    Energy Key Documents TEC Working Group Topic Groups Security Key Documents Key Documents Security TG Work Plan August 7, 2006 (24.31 KB) Security Lessons Learned Document August 2, 2006 (40.77 KB) Security Module (635.1 KB) STG Terms and Definitions from DOE 470.4 (18.54 KB) More Documents & Publications TEC Working Group Topic Groups Security Meeting Summaries TEC Meeting Summaries - April 2005 Presentations TEC Working Group Topic Groups Security Conference Call Summaries

  1. Key Dates | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Activities Key Activities Key Activities Bringing Innovative Manufacturing Technologies and Materials to Full "To Scale" Industrial Use Innovation is inherent in all of AMO's investment activities helping small, medium, and large manufacturers develop cutting-edge clean energy products and technology that reduce energy consumption in every stage or place it is used in industry. Built upon a foundation of strong public-private partnerships, our support of advanced manufacturing

  2. Key Dates | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Dates Visiting Faculty Program (VFP) VFP Home Eligibility Benefits Participant Obligations How to Apply Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A FeedbackShare Page At the submission deadline (shown in red) the application system will close, and no materials will be accepted after the submission deadline has passed. The Application System closes at 5:00 PM Eastern Time. VFP Term: Summer 2015 On-line Application Opens October 15, 2015 Applications

  3. DOE Announces More Key Administration Posts | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Administration Posts DOE Announces More Key Administration Posts March 20, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Dr. Steven E. Koonin, Under Secretary for Science, Department of Energy; David Sandalow, Assistant Secretary for Policy and International Affairs, Department of Energy; Ambassador Johnnie Carson, Assistant Secretary for African Affairs, State Department; Kathy

  4. Key Board Products and Special Reports - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Board Products and Special Reports Hanford Advisory Board Convening Report SSAB Guidance Memorandum of Understanding Membership Nomination and Appointment Process Operating Ground Rules Calendars Advice and Responses Full Board Meeting Information Committee Meeting Information Outgoing Board Correspondence Key Board Products and Special Reports HAB Annual Report HAB and Committee Lists Points of Contact Related Links Key Board Products and Special Reports Email Email Page | Print Print Page

  5. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Iron is the Key to Preserving Dinosaur Soft Tissue Iron is the Key to Preserving Dinosaur Soft Tissue Print Thursday, 21 August 2014 10:43 Researchers studying organic material from dinosaur bones have been able to show that the organic material in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected preservation-iron nanoparticles associated with dinosaur blood vessels were

  6. Guidance system for laser targets

    DOE Patents [OSTI]

    Porter, Gary D.; Bogdanoff, Anatoly

    1978-01-01

    A system for guiding charged laser targets to a predetermined focal spot of a laser along generally arbitrary, and especially horizontal, directions which comprises a series of electrostatic sensors which provide inputs to a computer for real time calculation of position, velocity, and direction of the target along an initial injection trajectory, and a set of electrostatic deflection means, energized according to a calculated output of said computer, to change the target trajectory to intercept the focal spot of the laser which is triggered so as to illuminate the target of the focal spot.

  7. Photosensitizer Conjugates For Pathogen Targeting

    DOE Patents [OSTI]

    Hasan, Tayyaba; Hamblin, Michael R.; Soukos, Nikos

    2002-10-08

    Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.

  8. Flight Path Target 4 East Port

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 East Port Target 4 East Port Links Flight Path Overview Target 4 East Port About Target 4 East Port Collaborators Publications Links

  9. Flight Path Target 4 East Port

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 East Port Target 4 East Port Links Flight Path Overview Target 4 East Port About Target 4 East Port Collaborators Publications Links

  10. Geothermal Regulations in Colorado - Land Ownership is the Key...

    Open Energy Info (EERE)

    Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference Paper: Geothermal Regulations in Colorado - Land Ownership is the Key Abstract Geothermal resources in...

  11. President Obama Announces More Key Administration Posts | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Addthis THE WHITE HOUSE Office of the Press Secretary WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration ...

  12. California Energy Incentive Programs: An Annual Update on Key...

    Office of Environmental Management (EM)

    Energy Incentive Programs: An Annual Update on Key Energy Issues and Financial Opportunities for Federal Sites in California California Energy Incentive Programs: An Annual Update ...

  13. Key Practical Issues in Strengthening Safety Culture, INSAG-15

    Office of Energy Efficiency and Renewable Energy (EERE)

    Key Pratical Issues in Strengthening Safety Culture, INSAG-15. A report by the International Nuclear Safety Advisory Gorup, International Atomic Energy Agency, Vienna, 2002.

  14. Key Parameters Governing the Energy Density of Rechargeable Li...

    Office of Scientific and Technical Information (OSTI)

    of Rechargeable LiS Batteries Citation Details In-Document Search Title: Key Parameters Governing the Energy Density of Rechargeable LiS Batteries Authors: Gao, Jie ; ...

  15. LANL breaks ground on key sediment control project

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sediment control project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately 2 million features are up to eight feet high and...

  16. Pantex Plant Achieves Key Safety Milestone Ahead of Schedule...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Achieves Key Safety Milestone Ahead of Schedule | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing...

  17. SECTION L -ATTACHMENT B - LISTING OF KEY PERSONNEL

    National Nuclear Security Administration (NNSA)

    B, Page 1 SECTION L ATTACHMENT B LISTING OF KEY PERSONNEL TITLE NAME [Note: Add/remove extra rows if needed]

  18. Two Key NNSA Site Offices Registerd Under International Quality Standard |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) Two Key NNSA Site Offices Registerd Under International Quality Standard June 24, 2005 PDF icon NR06-05.pdf

  19. Geothermal regulations in Colorado---land ownership is the key...

    Open Energy Info (EERE)

    ownership is the key Author P. Morgan Published Journal Geothermal Resources Council- Transactions, 2012 DOI Not Provided Check for DOI availability: http:crossref.org...

  20. TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring...

    Office of Environmental Management (EM)

    Radiation Monitoring Subgroup TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring Subgroup Radiation Monitoring Subgroup PDF icon Draft Work Plan - February 4,...

  1. Binding Behavior of Dopamine Transporter Key to Understanding...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Understanding Chemical Reactions in the Brain Binding Behavior of Dopamine Transporter Key to Understanding Chemical Reactions in the Brain Print Wednesday, 09 December 2015 00:00 ...

  2. Key Parameters Affecting DPF Performance Degradation and Impact...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Parameters Affecting DPF Performance Degradation and Impact on Lifetime Fuel Economy Key Parameters Affecting DPF Performance Degradation and Impact on Lifetime Fuel Economy ...

  3. Key Energy-Saving Projects for Smaller Facilities | Department...

    Broader source: Energy.gov (indexed) [DOE]

    save energy and how the Industrial Assessment Centers can help. Briggs & Stratton provides examples of projects and implementation plans which worked for them. Key Energy-Saving ...

  4. Hydrodynamic experiment provides key data for Stockpile Stewardship

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    weapon performance in the absence of full-scale underground nuclear testing," said Webster. Los Alamos hydrodynamic experiment provides key data for Stockpile Stewardship In...

  5. Liquid Water the Key to Arctic Cloud Radiative Closure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Water the Key to Arctic Cloud Radiative Closure For original submission and image(s), see ARM Research Highlights http:www.arm.govsciencehighlights Research Highlight...

  6. Energy Critical Infrastructure and Key Resources Sector-Specific

    Broader source: Energy.gov (indexed) [DOE]

    Energy Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) May 2007 Department of Energy Energy Sector ...

  7. NREL Fills Key Leadership Role for Energy Systems Security and...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fills Key Leadership Role for Energy Systems Security and Resilience April 6, 2015 Dr. ... a smart home, electricity storage, an electric vehicle charging station and solar panels. ...

  8. Rapid Compression Machine … A Key Experimental Device to Effectively...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    to Effectively Collaborate with Basic Energy Sciences Rapid Compression Machine A Key Experimental Device to Effectively Collaborate with Basic Energy Sciences 2011 DOE ...

  9. PEM Fuel Cell Technology, Key Research Needs and Approaches ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PEM FUEL CELL TECHNOLOGY Key Research Needs and Approaches Tom Jarvi UTC Power South ... Stationary CHP 40-80,000 hr components - seals, membranes Water management Robust systems ...

  10. Water dynamics clue to key residues in protein folding

    SciTech Connect (OSTI)

    Gao, Meng [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Zhu, Huaiqiu, E-mail: hqzhu@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Yao, Xin-Qiu [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China) [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Department of Biophysics, Kyoto University, Sakyo Kyoto 606-8502 (Japan); She, Zhen-Su, E-mail: she@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)

    2010-01-29

    A computational method independent of experimental protein structure information is proposed to recognize key residues in protein folding, from the study of hydration water dynamics. Based on all-atom molecular dynamics simulation, two key residues are recognized with distinct water dynamical behavior in a folding process of the Trp-cage protein. The identified key residues are shown to play an essential role in both 3D structure and hydrophobic-induced collapse. With observations on hydration water dynamics around key residues, a dynamical pathway of folding can be interpreted.