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Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

A Key Target for Diabetes Drugs | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Molten Metal Solidifies into a New Kind of Glass Molten Metal Solidifies into a New Kind of Glass Organic Polymers Show Sunny Potential A New Family of Quasicrystals Cool Muscles: Storing Elastic Energy for Flight A Further Understanding of Superconductivity Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor, which could help scientists design new drugs for type 2 diabetes. (Image courtesy of Katya Kadyshevskaya, The Scripps Research Institute) The three-dimensional (3-D) atomic structure of the human glucagon receptor has been identified by an international team of researchers carrying out

2

Computer-Aided Drug Target Search  

E-Print Network (OSTI)

Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery. It can potentially help in several aspects including: (1) determination of unknown therapeutic ...

Chen, Yuzong

3

Key Elements of and Materials Performance Targets for Highly Insulating  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Elements of and Materials Performance Targets for Highly Insulating Key Elements of and Materials Performance Targets for Highly Insulating Window Frames Title Key Elements of and Materials Performance Targets for Highly Insulating Window Frames Publication Type Journal Article LBNL Report Number LBNL-5099E Year of Publication 2011 Authors Gustavsen, Arlid, Steinar Grynning, Dariush K. Arasteh, Bjørn Petter Jelle, and Howdy Goudey Journal Energy and Buildings Volume 43 Issue 10 Pagination 2583-2594 Date Published 10/2011 Keywords Fenestration, heat transfer modeling, thermal performance, thermal transmittance, u-factor, window frames Abstract The thermal performance of windows is important for energy efficient buildings. Windows typically account for about 30-50 percent of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U-factor of their opaque counterparts (wall, roof and floor constructions). In well insulated buildings the U-factor of walls, roofs an floors can be between 0.1-0.2 W/(m2K). The best windows have U-values of about 0.7-1.0. It is therefore obvious that the U-factor of windows needs to be reduced, even though looking at the whole energy balance for windows (i.e. solar gains minus transmission losses) makes the picture more complex.

4

Unveiling the Molecular Structure of the Target of Many Drugs...  

NLE Websites -- All DOE Office Websites (Extended Search)

2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Unveiling the Molecular Structure of the Target of Many Drugs DECEMBER 3, 2007 Bookmark and Share Structure...

5

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

6

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

7

Echogenic Lipsomes for targeted drug delivery  

Science Conference Proceedings (OSTI)

Echogenic immunoliposomes (ELIP) are under development to enable ultrasound-controlled drug delivery. Mechanistic studies in vitro have revealed that stable cavitation is correlated with enhanced recombinant tissue Plasminogen Activator (rt-PA) thrombolysis, ...

Christy K. Holland; David D. McPherson

2009-06-01T23:59:59.000Z

8

A key target for diabetes drugs | Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

and Systems (AIMMS) of VU University Amsterdam; and Jesper Lau at Novo Nordisk (Denmark). Combining the new data with previous work, computational biochemists De Graaf and...

9

Synthetic LDL as targeted drug delivery vehicle  

SciTech Connect

The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

2012-08-28T23:59:59.000Z

10

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network (OSTI)

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

11

Double iterative optimisation for metabolic network-based drug target identification  

Science Conference Proceedings (OSTI)

The goal of drug discovery is to find molecules that manipulate enzymes in order to increase or decrease the production of desired compounds while incurring minimum side-effects. An important part of this problem is the identification of the target ... Keywords: E coli, bioinformatics, data mining, drug discovery, drug target identification, iterative optimisation, metabolic networks, target enzymes

Bin Song; Padmavati Sridhar; Tamer Kahveci; Sanjay Ranka

2009-05-01T23:59:59.000Z

12

In silico identification of putative drug targets in pseudomonas aeruginosa through metabolic pathway analysis  

Science Conference Proceedings (OSTI)

Comparative genomic analysis between pathogens and the host Homo sapiens has led to identification of novel drug targets. Microbial drug target identification and validation has been the latest trend in pharmacoinformatics. In order to identify a suitable ... Keywords: KEGG, MODELLER, comparative microbial genomics, homo sapiens, homology, kdsA, kdsB, lpxC, potential drug targets, pseudomonas aeruginosa, waaG

Deepak Perumal; Chu Sing Lim; Meena K. Sakharkar

2007-10-01T23:59:59.000Z

13

International Experience with Key Program Elements of IndustrialEnergy Efficiency or Greenhouse Gas Emissions Reduction Target-SettingPrograms  

SciTech Connect

Target-setting agreements, also known as voluntary ornegotiated agreements, have been used by a number of governments as amechanism for promoting energy efficiency within the industrial sector. Arecent survey of such target-setting agreement programs identified 23energy efficiency or GHG emissions reduction voluntary agreement programsin 18 countries. International best practice related to target-settingagreement programs calls for establishment of a coordinated set ofpolicies that provide strong economic incentives as well as technical andfinancial support to participating industries. The key program elementsof a target-setting program are the target-setting process,identification of energy-saving technologies and measures usingenergy-energy efficiency guidebooks and benchmarking as well as byconducting energy-efficiency audits, development of an energy-savingsaction plan, development and implementation of energy managementprotocols, development of incentives and supporting policies, monitoringprogress toward targets, and program evaluation. This report firstprovides a description of three key target-setting agreement programs andthen describes international experience with the key program elementsthat comprise such programs using information from the three keytarget-setting programs as well as from other international programsrelated to industrial energy efficiency or GHG emissionsreductions.

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-02-02T23:59:59.000Z

14

Finding the 3-D Structure of a Key Drug Target for Diabetes ...  

NLE Websites -- All DOE Office Websites (Extended Search)

Cool Muscles: Storing Elastic Energy for Flight A Further Understanding of Superconductivity New Family of Tiny Crystals Glow Bright in LED Lights Science Highlights...

15

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs  

E-Print Network (OSTI)

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, China; b Department University, Chongqing 400715, China; and e Department of Pathology and Laboratory Medicine, Shands Cancer

Tan, Weihong

16

Key Elements of and Materials Performance Targets for Highly Insulating Window Frames  

DOE Green Energy (OSTI)

The thermal performance of windows is important for energy efficient buildings. Windows typically account for about 30-50 percent of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U-factor of their opaque counterparts (wall, roof and floor constructions). In well insulated buildings the U-factor of walls, roofs an floors can be between 0.1-0.2 W/(m2K). The best windows have U-values of about 0.7-1.0. It is therefore obvious that the U-factor of windows needs to be reduced, even though looking at the whole energy balance for windows (i.e. solar gains minus transmission losses) makes the picture more complex.In high performance windows the frame design and material use is of utmost importance, as the frame performance is usually the limiting factor for reducing the total window U-factor further. This paper describes simulation studies analyzing the effects on frame and edge-of-glass U-factors of different surface emissivities as well as frame material and spacer conductivities. The goal of this work is to define materials research targets for window frame components that will result in better frame thermal performance than is exhibited by the best products available on the market today.

Gustavsen, Arild; Grynning, Steinar; Arasteh, Dariush; Jelle, Bjorn Petter; Goudey, Howdy

2011-03-28T23:59:59.000Z

17

Synthetic Nano-Low Density Lipoprotein as Targeted Drug DeliveryVehicle for Glioblastoma Multiforme  

SciTech Connect

This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDLuptake by GBM cells was LDL receptor specific and dependent on cellreceptor number. It is suggested that these synthetic particles can serveas a delivery vehicle for hydophobic anti-tumor drugs by targeting theLDL receptor.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu,Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-06-14T23:59:59.000Z

18

Developing a commercial production process for 500,000 targets per day: A key challenge for inertial fusion energy  

Science Conference Proceedings (OSTI)

As is true for current-day commercial power plants, a reliable and economic fuel supply is essential for the viability of future Inertial Fusion Energy (IFE) [Energy From Inertial Fusion, edited by W. J. Hogan (International Atomic Energy Agency, Vienna, 1995)] power plants. While IFE power plants will utilize deuterium-tritium (DT) bred in-house as the fusion fuel, the 'target' is the vehicle by which the fuel is delivered to the reaction chamber. Thus the cost of the target becomes a critical issue in regard to fuel cost. Typically six targets per second, or about 500 000/day are required for a nominal 1000 MW(e) power plant. The electricity value within a typical target is about $3, allocating 10% for fuel cost gives only 30 cents per target as-delivered to the chamber center. Complicating this economic goal, the target supply has many significant technical challenge - fabricating the precision fuel-containing capsule, filling it with DT, cooling it to cryogenic temperatures, layering the DT into a uniform layer, characterizing the finished product, accelerating it to high velocity for injection into the chamber, and tracking the target to steer the driver beams to meet it with micron-precision at the chamber center.

Goodin, D.T.; Alexander, N.B.; Besenbruch, G.E.; Bozek, A.S.; Brown, L.C.; Flint, G.W.; Kilkenny, J.D.; McQuillan, B.W.; Nikroo, A.; Paguio, R.R.; Petzoldt, R.W.; Schroen, D.G.; Sheliak, J.D.; Vermillion, B.A. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Carlson, L.C.; Goodman, P.; Maksaereekul, W.; Raffray, R.; Spalding, J.; Tillack, M.S. [University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92023 (United States)] (and others)

2006-05-15T23:59:59.000Z

19

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and  

E-Print Network (OSTI)

Background: The Inflammasomes are multi-protein complexes that regulate caspase-1 activation and the production of the pro-inflammatory cytokine IL-1b. Previous studies identified a class of diarylsulfonylurea containing compounds called Cytokine Release Inhibitory Drugs (CRIDs) that inhibited the post-translational processing of IL-1b. Further work identified Glutathione S-Transferase Omega 1 (GSTO1) as a possible target of these CRIDs. This study aimed to investigate the mechanism of the inhibitory activity of the CRID CP-456,773 (termed CRID3) in light of recent advances in the area of inflammasome activation, and to clarify the potential role of GSTO1 in the regulation of IL-1b production. Methodology and Results: In murine bone marrow derived macrophages, CRID3 inhibited IL-1b secretion and caspase 1 processing in response to stimulation of NLRP3 and AIM2 but not NLRC4. CRID3 also prevented AIM2 dependent pyroptosis in contrast to the NLRP3 inhibitors glyburide and parthenolide, which do not inhibit AIM2 activation. Confocal microscopy and Western blotting assays indicated that CRID3 inhibited the formation of ASC complexes or specks in response to NLRP3 and AIM2 stimulation. Co-immunoprecipitation assays show that GSTO1 interacted with ASC. Significance: These results identify CRID3 as a novel inhibitor of the NLRP3 and AIM2 inflammasomes and provide an insight into the mechanism of action of this small molecule. In addition GSTO1 may be a component of the inflammasome

Aim Inflammasomes; Rebecca C. Coll; Luke A. J. Oneill

2011-01-01T23:59:59.000Z

20

Bacterial magnetosome: a novel biogenetic magnetic targeted drug carrier with potential multifunctions  

Science Conference Proceedings (OSTI)

Bacterial magnetosomes (BMs) synthesized by magnetotactic bacteria have recently drawn great interest due to their unique features. BMs are used experimentally as carriers for antibodies, enzymes, ligands, nucleic acids, and chemotherapeutic drugs. In ...

Jianbo Sun; Ying Li; Xing-Jie Liang; Paul C. Wang

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network (OSTI)

Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

22

Target  

NLE Websites -- All DOE Office Websites (Extended Search)

Lifetime measurements in Lifetime measurements in inverse kinematics Coulex Target e.g. C Stopper e.g. Cu Beam X X * C Si-Det. Yale Plunger 120 Te at 300 MeV Plunger foils Si-Detector Compton-suppressed Clover detectors (8) 50% Coulomb- barrier )] ( exp[ 1 ) ( 0 d d d P - - - = λ Probability of emitting gamma-ray while in-flight: From data: ) ( ) ( ) ( ) ( ) ( d I d I d P total shifted γ γ = where ) ( ) ( γ γ γ γ θ ε W E N I = Lifetime analysis For example: Valence proton symmetry Data from NNDC, WNSL ( 120 Te), NBI group ( 116 Te), Cologne ( 114 Te) B(E2)up [e 2 b 2 ] N A.A. Pasternak et al., EPJA 13, 435 (2002) O. Möller et al., PRC 71, 064324 (2005) Study deviations from (collective) expectations -> needs a fast and easy way to obtain data -> inverse RDDS well suited! Important in inverse kinematics: Deorientation F I J Large v/c => except for relativistic

23

Membrane protein kit may lead to better targeted drugs | Argonne National  

NLE Websites -- All DOE Office Websites (Extended Search)

Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne scientists received an R&D100 Award for using Rhodobacter to develop a new system for growing membrane proteins used in drug discovery research. Image by Sheng-Wen Chui, University of Oxford. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne

24

Key Outcomes:  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

INDIAN COUNTRY ENERGY AND INFRASTRUCTURE WORKING GROUP ICEIWG Key Points & Action Items Inaugural Meeting Thursday, August 25, 2011 Renaissance Denver Hotel Denver, Colorado...

25

KEY PERSONNEL  

National Nuclear Security Administration (NNSA)

APPENDIX J KEY PERSONNEL 07032013 TITLE NAME President Christopher C. Gentile Vice President, Operations Robin Stubenhofer Director, Sr. Program Management Rick Lavelock...

26

Key Documents  

Science Conference Proceedings (OSTI)

AOCS by-laws, code of ethics and anti trust policy established during our 100+ legacy. Key Documents AOCS History and Governance about us aocs committees contact us division council fats governing board history oils professionals science value cen

27

Key Outcomes:  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Key Points & Action Items Key Points & Action Items Inaugural Meeting Thursday, August 25, 2011 Renaissance Denver Hotel Denver, Colorado Participants Tracey LeBeau, Director, Pilar Thomas, Deputy Director, and Brandt Petrasek, Special Assistant, Department of Energy, Office of Indian Energy Policy and Programs; Vice Chairman Ronald Suppah and Jim Manion, Confederated Tribes of the Warm Springs Reservation of Oregon; William Micklin, Ewiiaapaayp Band of Kumeyaay Indians; Councilman Barney Enos, Jr., Jason Hauter, Gila River Indian Community; Mato Standing High, Rosebud Sioux Tribe; R. Allen Urban, Yocha Dehe Wintun Nation; Glen Andersen, Scott Hendrick, Brooke Oleen, Jacquelyn Pless, Jim Reed and Julia Verdi, National Conference of State Legislatures-staff

28

Key Workplace Documents Federal Publications  

E-Print Network (OSTI)

, the Administration in 2007 concluded agreements with China on toys, food and feed, drugs and medical devicesKey Workplace Documents Federal Publications Cornell University ILR School Year 2008 China/498 #12;Order Code RL33536 China-U.S. Trade Issues Updated March 7, 2008 Wayne M. Morrison Specialist

29

Crypto Key Management Framework  

Science Conference Proceedings (OSTI)

... A Framework for Designing Cryptographic Key Management Systems ... A Framework for Designing Cryptographic Key Management Systems ...

2013-08-13T23:59:59.000Z

30

BUDGET KEY DATES  

Science Conference Proceedings (OSTI)

BUDGET KEY DATES. For Immediate Release: December 15, 2009. Contact: Diane Belford 301-975-8400. Budget Key Dates.

2013-06-16T23:59:59.000Z

31

A Key Enzyme to the Potency of an Anticancer Agent  

NLE Websites -- All DOE Office Websites (Extended Search)

A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with...

32

Assess the key physics that underpins high-hydro coupling-efficiency in NDCX-II experiments and high-gain heavy ion direct drive target designs using proven hydro codes like HYDRA  

E-Print Network (OSTI)

physics that underpins high-hydro coupling-efficiency in N Dtarget designs using proven hydro codes like H Y D R A . byF E targets, we have studied hydro and implosion efficiency

Barnard, J. J.

2010-01-01T23:59:59.000Z

33

UIC Developing Drug for SARS  

NLE Websites -- All DOE Office Websites (Extended Search)

but their backbones. When viruses mutate, as they frequently do, thwarting the action of drugs, the mutations typically occur in these sidechains. "By targeting the backbone, we...

34

Group key management  

SciTech Connect

This report describes an architecture and implementation for doing group key management over a data communications network. The architecture describes a protocol for establishing a shared encryption key among an authenticated and authorized collection of network entities. Group access requires one or more authorization certificates. The implementation includes a simple public key and certificate infrastructure. Multicast is used for some of the key management messages. An application programming interface multiplexes key management and user application messages. An implementation using the new IP security protocols is postulated. The architecture is compared with other group key management proposals, and the performance and the limitations of the implementation are described.

Dunigan, T.; Cao, C.

1997-08-01T23:59:59.000Z

35

In vitro characterization of pluronic F127 and D-?-tocopheryl polyethylene glycol 1000 succinate mixed micelles as nanocarriers for targeted anticancer-drug delivery  

Science Conference Proceedings (OSTI)

Mixed micelles of Pluronic F127 and d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) in different molar ratios (10 : 0, 7 : 3, 5 : 5, and 3 : 7) were prepared to characterize this system as nanocarriers for targeted delivery of chemotherapeutic ...

Adeel Masood Butt, Mohd Cairul Iqbal Mohd Amin, Haliza Katas, Narong Sarisuta, Wasu Witoonsaridsilp, Ruthairat Benjakul

2012-01-01T23:59:59.000Z

36

Overview of Indian Hydrogen Program and Key Safety Issues of...  

NLE Websites -- All DOE Office Websites (Extended Search)

Hydrogen Energy Road Map - Initiatives - Target 2020 : GIFT - Programme in India - CNG - H 2 Programme - Partnership - Technology Development - Concerns & Challenges * Key...

37

Basics about CIM technology and key  

E-Print Network (OSTI)

Basics about CIM® technology and key applications Ales Strancar March, 2011 #12;Leaders in Monolith monolithic technology (CIM®). 4 USA patents granted including their foreign equivalents, more pending. #12;Important Milestones · 2002: First Drug Master File (DMF) for CIM® DEAE supports. · 2002: Pass first FDA

Lebendiker, Mario

38

Crypto Key Management Framework  

Science Conference Proceedings (OSTI)

... responsible to executive-level management (eg, the Chief Information Officer) for the ... entity information, keys, and metadata into a database used by ...

2013-08-15T23:59:59.000Z

39

The Key Agreement Schemes  

Science Conference Proceedings (OSTI)

... The three key derivation functions include KDF in Counter Mode, KDF in Feedback Mode, and KDF in Double-Pipeline Iteration Mode. ...

2013-04-23T23:59:59.000Z

40

Cryptographic Key Management Workshop 2010  

Science Conference Proceedings (OSTI)

Cryptographic Key Management Workshop 2010. Purpose: ... Related Project(s): Cryptographic Key Management Project. Details: ...

2013-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Optical key system  

Science Conference Proceedings (OSTI)

An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

Hagans, K.G.; Clough, R.E.

2000-04-25T23:59:59.000Z

42

Optical key system  

DOE Patents (OSTI)

An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

Hagans, Karla G. (Livermore, CA); Clough, Robert E. (Danville, CA)

2000-01-01T23:59:59.000Z

43

SR Key Facts  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Facts Savannah River Site Budget FY 2011 Budget Summary FY 2011 SRS EM Program Budget Summary FY 2012 Presidential Budget Request for SRS FY 2014 SRS EM Budget Presentation...

44

Key masking using biometry  

Science Conference Proceedings (OSTI)

We construct an abstract model based on a fundamental similarity property, which takes into account parametric dependencies and reflects a specific collection of requirements. We consider a method for masking a cryptographic key using biometry, which ...

A. L. Chmora

2011-06-01T23:59:59.000Z

45

Key Emergency Information  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Emergency Information What to Do if an Emergency Arises DOE is committed to public safety in the event an emergency arises. You will likely be made aware that an emergency is...

46

Prescription Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Prescription Drugs Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue Cross and Blue Shield of New Mexico (BCBSNM) health plan includes a prescription drug benefit administered by Prime Therapeutics. The cost of the prescription drug plan is included in your medical premiums. Coverage The co-pays for prescription drugs are based on a 3-tier prescription drug benefit. Co-payments are different for formulary or non-formulary, generic, or brand/preferred name. Review the BCBSNM Drug List (pdf) to find out which tier a specific drug falls under. Co-pays Prescription drug co-pays vary from plan to plan. 2013 EPO Summary of Benefits (pdf) 2013 PPO Summary of Benefits (pdf)

47

Production Targets  

E-Print Network (OSTI)

Hall (2005), Prices, Production, and Inventories over theProduction Targets ? Guillermo Caruana CEMFI caruana@cem?.esthe theory using monthly production targets of the Big Three

Caruana, Guillermo; Einav, Liran

2005-01-01T23:59:59.000Z

48

ARM - Key Science Questions  

NLE Websites -- All DOE Office Websites (Extended Search)

govScienceKey Science Questions govScienceKey Science Questions Science Research Themes Research Highlights Journal Articles Collaborations Atmospheric System Research (ASR) ARM Science Team Meetings User Meetings Annual Meetings of the Atmospheric System Research (ASR) Science Team and Fall Working Groups Accomplishments Read about the 20 years of accomplishments (PDF, 696KB) from the ARM Program and user facility. Performance Metrics ASR Metrics 2009 2008 2007 2006 Key Science Questions The role of clouds and water vapor in climate change is not well understood; yet water vapor is the largest greenhouse gas and directly affects cloud cover and the propagation of radiant energy. In fact, there may be positive feedback between water vapor and other greenhouse gases. Carbon dioxide and other gases from human activities slightly warm the

49

Key Research Results Achievement  

E-Print Network (OSTI)

daylighting options for specific spaces with sample design layouts · Various HVAC system types that achieve%energysavingsovercode.NREL developedthesimulationtoolsandledthe committeethatproducedtheguides. Key Result TheAdvanced school in Greensburg, Kansas, used many of the energy efficiency measures outlined in the Advanced Energy

50

EXPERT REVIEW Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release  

E-Print Network (OSTI)

ABSTRACT Micelles are colloidal particles with a size around 5100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a magic bullet a major step forward. KEY WORDS imaging. micelles. nanomedicine. theranostics. triggered release

C. Oerlemans

2010-01-01T23:59:59.000Z

51

Improving translation via targeted paraphrasing  

Science Conference Proceedings (OSTI)

Targeted paraphrasing is a new approach to the problem of obtaining cost-effective, reasonable quality translation that makes use of simple and inexpensive human computations by monolingual speakers in combination with machine translation. The key insight ...

Philip Resnik; Olivia Buzek; Chang Hu; Yakov Kronrod; Alex Quinn; Benjamin B. Bederson

2010-10-01T23:59:59.000Z

52

Targeting of drugs and nanoparticles to tumors  

E-Print Network (OSTI)

The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as ...

Ruoslahti, Erkki

53

AP Key Accomplishments  

NLE Websites -- All DOE Office Websites (Extended Search)

Recent Key Accomplishments Recent Key Accomplishments Reduction of Carbon Dioxide Mechanistic insight into CO2 hydrogenation Rapid Transfer of Hydride Ion from a Ruthenium Complex to C1 Species in Water Reversible Hydrogen Storage using CO2 and a Proton-Switchable Iridium Catalyst in Aqueous Media Nickel(II) Macrocycles: Highly Efficient Electrocatalysts for the Selective Reduction of CO2 to CO Calculation of Thermodynamic Hydricities and the Design of Hydride Donors for CO2 Reduction Mechanisms for CO Production from CO2 Using Re(bpy)(CO)3X Catalysts Hydrogen Production Biomass-derived electrocatalytic composites for hydrogen evolution Hydrogen-Evolution Catalysts Based on NiMo Nitride Nanosheets Water Oxidation Enabling light-driven water oxidation via a low-energy RuIV=O intermediate

54

The Workings of a Key Staph Enzyme and How to Block It | Advanced...  

NLE Websites -- All DOE Office Websites (Extended Search)

who co-led the study. "Blocking their activity can lead to new cholesterol-lowering drugs, antibiotics that cure staph infections, and drugs that target the parasites that...

55

Cryptographic Key Management Workshop 2012  

Science Conference Proceedings (OSTI)

Cryptographic Key Management Workshop 2012. Purpose: NIST is conducting a two-day Key Management Workshop on September 10-11. ...

2013-08-01T23:59:59.000Z

56

Design and in vitro development of resorbable urologic drug delivery device  

E-Print Network (OSTI)

Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous ...

Tobias, Irene S. (Irene Sophie)

2008-01-01T23:59:59.000Z

57

Available Technologies: Non-catalytic Domain Targets in MMPs ...  

Biofuels; Biotechnology & Medicine. Diagnostics and Therapeutics; Medical Devices; ... might be the correct target for drugs that would block tumor growth or metastases.

58

Background on Quantum Key Distribution  

Science Conference Proceedings (OSTI)

... Background on Quantum Key Distribution. ... If someone, referred to by cryptographers as Eve, tries to eavesdrop on the transmission, she will not ...

2011-08-02T23:59:59.000Z

59

Partnership in key exchange protocols  

Science Conference Proceedings (OSTI)

In this paper, we investigate the notion of partnership as found in security models for key exchange protocols. Several different approaches have been pursued to define partnership, with varying degrees of success. We aim to provide an overview and criticism ... Keywords: key exchange, partnership, session identifier

Kazukuni Kobara; Seonghan Shin; Mario Strefler

2009-03-01T23:59:59.000Z

60

Key Activities | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Key Activities Key Activities Key Activities The Water Power Program conducts work in four key areas at the forefront of water power research. The Program is structured to help the United States meet its growing energy demands sustainably and cost-effectively by developing innovative renewable water power technologies, breaking down market barriers to deployment, building the infrastructure to test new technologies, and assessing water power resources for integration into our nation's grid. Research and Development Introduce and advance new marine and hydrokinetic technologies to provide sustainable and cost-effective renewable energy from the nation's waves, tides, currents, and ocean thermal gradients. Research and develop innovative hydropower technologies to sustainably tap our country's diverse water resources including rivers,

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Key China Energy Statistics 2011  

NLE Websites -- All DOE Office Websites (Extended Search)

1 Title Key China Energy Statistics 2011 Publication Type Chart Year of Publication 2012 Authors Levine, Mark D., David Fridley, Hongyou Lu, and Cecilia Fino-Chen Date Published...

62

Key China Energy Statistics 2012  

NLE Websites -- All DOE Office Websites (Extended Search)

2 Title Key China Energy Statistics 2012 Publication Type Chart Year of Publication 2012 Authors Levine, Mark D., David Fridley, Hongyou Lu, and Cecilia Fino-Chen Date Published...

63

Accelerator target  

DOE Patents (OSTI)

A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

Schlyer, David J. (Bellport, NY); Ferrieri, Richard A. (Patchogue, NY); Koehler, Conrad (Miller Place, NY)

1999-01-01T23:59:59.000Z

64

Accelerator target  

DOE Patents (OSTI)

A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

1999-06-29T23:59:59.000Z

65

EPAct Transportation Regulatory Activities: Key Terms  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Terms Key Terms to someone by E-mail Share EPAct Transportation Regulatory Activities: Key Terms on Facebook Tweet about EPAct Transportation Regulatory Activities: Key Terms on Twitter Bookmark EPAct Transportation Regulatory Activities: Key Terms on Google Bookmark EPAct Transportation Regulatory Activities: Key Terms on Delicious Rank EPAct Transportation Regulatory Activities: Key Terms on Digg Find More places to share EPAct Transportation Regulatory Activities: Key Terms on AddThis.com... Home About Covered Fleets Compliance Methods Alternative Fuel Petitions Resources Guidance Documents Statutes & Regulations Program Annual Reports Fact Sheets Newsletter Case Studies Workshops Tools Key Terms FAQs Key Terms The Energy Policy Act (EPAct) includes specific terminology related to

66

EPAct Transportation Regulatory Activities: Key Federal Statutes  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Key Federal Statutes to someone by E-mail Share EPAct Transportation Regulatory Activities: Key Federal Statutes on Facebook Tweet about EPAct Transportation Regulatory Activities: Key Federal Statutes on Twitter Bookmark EPAct Transportation Regulatory Activities: Key Federal Statutes on Google Bookmark EPAct Transportation Regulatory Activities: Key Federal Statutes on Delicious Rank EPAct Transportation Regulatory Activities: Key Federal Statutes on Digg Find More places to share EPAct Transportation Regulatory Activities: Key Federal Statutes on AddThis.com... Home About Contacts Covered Fleets Compliance Methods Alternative Fuel Petitions Resources Key Federal Statutes These are excerpts from federal statutes that established key Energy Policy Act (EPAct) transportation regulatory activities.

67

Targeting NRF2 signaling for cancer chemoprevention  

SciTech Connect

Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

Kwak, Mi-Kyoung, E-mail: mkwak@ynu.ac.k [College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749 (Korea, Republic of); Kensler, Thomas W. [Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (United States)

2010-04-01T23:59:59.000Z

68

KIDS: keyed intrusion detection system  

Science Conference Proceedings (OSTI)

Since most current network attacks happen at the application layer, analysis of packet payload is necessary for their detection. Unfortunately malicious packets may be crafted to mimic normal payload, and so avoid detection if the anomaly detection method ... Keywords: Kerckhoffs' principle, anomaly detection, keyed IDS, network intrusion detection, word model

Sasa Mrdovic; Branislava Drazenovic

2010-07-01T23:59:59.000Z

69

Key technology trends - Satellite systems  

Science Conference Proceedings (OSTI)

This paper is based on material extracted from the WTEC Panel Report Global Satellite Communications Technology and Systems, December 1998. It presents an overview of key technology trends in communications satellites in the last few years. After the ... Keywords: Communications satellites, Satellite communications, Satellite technology overview

Charles W. Bostian; William T. Brandon; Alfred U. Mac Rae; Christoph E. Mahle; Stephen A. Townes

2000-08-01T23:59:59.000Z

70

A Key Enzyme to the Potency of an Anticancer Agent  

NLE Websites -- All DOE Office Websites (Extended Search)

A Key Enzyme to the Potency of A Key Enzyme to the Potency of an Anticancer Agent A Key Enzyme to the Potency of an Anticancer Agent Print Wednesday, 28 May 2008 00:00 Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline 8.2.2, discovered and characterized the chlorinating SalL enzyme, a crucial component in sal A biosynthesis that uses a unique chlorine-activating mechanism. Chlorine-Loving Enzyme Speeds Things Up

71

Rotating Plasma Finding is Key for ITER  

NLE Websites -- All DOE Office Websites (Extended Search)

Plasma Finding is Key for ITER Rotating Plasma Finding is Key for ITER PlasmaTurbulenceCSChang.png Tokamak turbulence showing inward-propagating streamers from normalized...

72

Nuclear physics with internal targets in electron storage rings  

Science Conference Proceedings (OSTI)

Two key experiments in nuclear physics will be discussed in order to illustrate the advantages of the internal target method and demonstrate the power of polarization techniques in electron scattering studies. The progress of internal target experiments will be discussed and the technology of internal polarized target development will be reviewed.

Roy J. Holt

1987-01-01T23:59:59.000Z

73

WP1: Targeted and informative forecast system design  

E-Print Network (OSTI)

WP1: Targeted and informative forecast system design Emma Suckling, Leonard A. Smith and David Stainforth EQUIP Meeting ­ August 2011 Edinburgh #12;Targeted and informative forecast system design Develop models to support decision making (1.4) #12;Targeted and informative forecast system design KEY QUESTIONS

Stevenson, Paul

74

Vehicle Technologies Office: Key Activities in Vehicles  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Activities in Key Activities in Vehicles to someone by E-mail Share Vehicle Technologies Office: Key Activities in Vehicles on Facebook Tweet about Vehicle Technologies Office: Key Activities in Vehicles on Twitter Bookmark Vehicle Technologies Office: Key Activities in Vehicles on Google Bookmark Vehicle Technologies Office: Key Activities in Vehicles on Delicious Rank Vehicle Technologies Office: Key Activities in Vehicles on Digg Find More places to share Vehicle Technologies Office: Key Activities in Vehicles on AddThis.com... Key Activities Mission, Vision, & Goals Plans, Implementation, & Results Organization & Contacts National Laboratories Budget Partnerships Key Activities in Vehicles We conduct work in four key areas to develop and deploy vehicle technologies that reduce the use of petroleum while maintaining or

75

Fuel Cell Technologies Office: Key Activities  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Activities to Key Activities to someone by E-mail Share Fuel Cell Technologies Office: Key Activities on Facebook Tweet about Fuel Cell Technologies Office: Key Activities on Twitter Bookmark Fuel Cell Technologies Office: Key Activities on Google Bookmark Fuel Cell Technologies Office: Key Activities on Delicious Rank Fuel Cell Technologies Office: Key Activities on Digg Find More places to share Fuel Cell Technologies Office: Key Activities on AddThis.com... Key Activities Plans, Implementation, & Results Accomplishments Organization Chart & Contacts Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells Technology Validation Manufacturing Codes & Standards Education Systems Analysis Contacts Key Activities The Fuel Cell Technologies Office conducts work in several key areas to

76

Exploring Key Orientations of Small Molecules to Disrupt Protein-protein Interactions  

E-Print Network (OSTI)

Protein-protein interactions (PPIs) are attractive targets because of their therapeutic potential. One approach to design small molecules that can disrupt the PPIs is to use structural information of proteins. With this approach, triazole-based peptidomimetics that mimic beta-turn hot-spot regions in neurotrophins were synthesized. The monovalent mimics were assembled into bivalent mimics via a combinatorial method. Three different bivalent mimics were prepared for different studies. Bivalent mimics with long-linkers bound to TrkA or TrkC receptor and showed partial antagonism for the receptors. Other mimics were conjugated with cytotoxic compounds and they were used for TrkC targeted drug delivery. The last group of bivalent mimics previously showed targeted delivery effects for pancreatic cancer cells. In this study, we synthesized Eu-chelated bivalent mimics to perform a competitive binding assay for pancreatic cancer cells. Previous research in our group focused on design of secondary structures' mimics on rigid scaffolds as "minimalist mimics." We sought to establish structural design criteria for the minimalist mimics, and we wanted to propose that sets of such compounds could mimic local pairs of amino acids in any secondary structures as "universal peptidomimetics." Thus, we designed five compounds, such as oxazoline-, pyrrole-, dyine- "kinked" and "linear" bistrizole-based peptidomimetics, and performed molecular modelings, DFT calculations, and QMD for them to validate our hypothesis. On the concepts of "minimalist mimics" and "universal peptidomimetics," we developed the C alpha ? C beta vector matching program to evaluate preferred orientations of C alpha - C beta coordinates for secondary structures. We applied the program to omegatides and pyrrolinone-pyrrolidine oligomers. The compounds matched better with strands than for helices. We expanded the C alpha ? C beta vector matching idea to a method that ranks preferred conformations of small molecules on any combination of three interface side-chains in all structurally characterized PPIs. We developed a PDB mining program (explores key orientation, EKO) to do this, and EKO applied to pyrrolinone-pyrrolidine oligomers to find targets. EKO found several interesting targets, such as AICAR Tfase, GAPDH, and HIV-1 protease. HIV-1 dimerization inhibition and Zhang-Poorman kinetic assays were performed to validate our hypothesis, and the results showed that pyrrolinone-pyrrolidine derivatives inhibited HIV-1 dimerization.

Ko, Eunhwa

2012-05-01T23:59:59.000Z

77

Algorithms for dynamic multicast key distribution  

Science Conference Proceedings (OSTI)

We study the problem of multicast key distribution for group security. Secure group communication systems typically rely on a group key, which is a secret shared among the members of the group. This key is used to provide privacy by encrypting all group ... Keywords: Dynamic key distribution, experimental algorithms, multicast

Justin Goshi; Richard E. Ladner

2007-02-01T23:59:59.000Z

78

Multiparty quantum key agreement with single particles  

Science Conference Proceedings (OSTI)

Two conditions must be satisfied in a secure quantum key agreement (QKA) protocol: (1) outside eavesdroppers cannot gain the generated key without introducing any error; (2) the generated key cannot be determined by any non-trivial subset of the participants. ... Keywords: Quantum cryptography, Quantum information, Quantum key agreement

Bin Liu; Fei Gao; Wei Huang; Qiao-Yan Wen

2013-04-01T23:59:59.000Z

79

Protein encapsulated magnetic carriers for micro/nanoscale drug delivery systems.  

SciTech Connect

Novel methods for drug delivery may be based on nanotechnology using non-invasive magnetic guidance of drug loaded magnetic carriers to the targeted site and thereafter released by external ultrasound energy. The key building block of this system is to successfully synthesize biodegradable, magnetic drug carriers. Magnetic carriers using poly(D,L-lactide-co-glycolide) (PLGA) or poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) as matrix materials were loaded with bovine serum albumin (BSA) by a double-emulsion technique. BSA-loaded magnetic microspheres were characterized for size, morphology, surface charge, and magnetization. The BSA encapsulation efficiency was determined by recovering albumin from the microspheres using dimethyl sulfoxide and 0.05N NaOH/0.5% SDS then quantifying with the Micro-BCA protein assay. BSA release profiles were also determined by the Micro-BCA protein assay. The microspheres had drug encapsulation efficiencies up to 90% depending on synthesis parameters. Particles were spherical with a smooth or porous surface having a size range less than 5 {mu}m. The surface charge (expressed as zeta potential) was near neutral, optimal for prolonged intravascular survival. The magnetization of these BSA loaded magnetic carriers was 2 to 6 emu/g, depending on the specific magnetic materials used during synthesis.

Xie, Y.; Kaminski, M. D.; Mertz, C. J.; Finck, M. R.; Guy, S. G.; Chen, H.; Rosengart, A. J.; Chemical Engineering; Univ. of Chicago, Pritzker School of Medicine

2005-01-01T23:59:59.000Z

80

SunShot Initiative: Key Activities  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Activities Key Activities Printable Version Share this resource Send a link to SunShot Initiative: Key Activities to someone by E-mail Share SunShot Initiative: Key Activities on Facebook Tweet about SunShot Initiative: Key Activities on Twitter Bookmark SunShot Initiative: Key Activities on Google Bookmark SunShot Initiative: Key Activities on Delicious Rank SunShot Initiative: Key Activities on Digg Find More places to share SunShot Initiative: Key Activities on AddThis.com... Concentrating Solar Power Photovoltaics Systems Integration Balance of Systems Key Activities Under the SunShot Initiative, the DOE Solar Office issues competitive solicitations that fund selective research projects aimed at transforming the ways the United States generates, stores, and utilizes solar energy.

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Alternative Fuels Data Center: Key Federal Legislation  

Alternative Fuels and Advanced Vehicles Data Center (EERE)

Key Federal Key Federal Legislation to someone by E-mail Share Alternative Fuels Data Center: Key Federal Legislation on Facebook Tweet about Alternative Fuels Data Center: Key Federal Legislation on Twitter Bookmark Alternative Fuels Data Center: Key Federal Legislation on Google Bookmark Alternative Fuels Data Center: Key Federal Legislation on Delicious Rank Alternative Fuels Data Center: Key Federal Legislation on Digg Find More places to share Alternative Fuels Data Center: Key Federal Legislation on AddThis.com... More in this section... Federal State Advanced Search All Laws & Incentives Sorted by Type Key Federal Legislation The information below includes a brief chronology and summaries of key federal legislation related to alternative fuels and vehicles, air quality,

82

Bugs, Drugs & Smoke  

E-Print Network (OSTI)

burden of drug-resistant TB, including four China, India,on drug-resistant TB organized by WHO in Beijing, China, inChina, the Democratic Republic of the Congo, Estonia, Ethiopia, Georgia, India, Indonesia, in new drug-

WHO

2012-01-01T23:59:59.000Z

83

Renewable Energy Community: Key Elements  

NLE Websites -- All DOE Office Websites (Extended Search)

of Energy of Energy Office of Energy Efficiency & Renewable Energy National Renewable Energy Laboratory Innovation for Our Energy Future A Renewable Energy Community: Key Elements A reinvented community to meet untapped customer needs for shelter and transportation with minimal environmental impacts, stable energy costs, and a sense of belonging N. Carlisle, J. Elling, and T. Penney Technical Report NREL/TP-540-42774 January 2008 NREL is operated by Midwest Research Institute ● Battelle Contract No. DE-AC36-99-GO10337 National Renewable Energy Laboratory 1617 Cole Boulevard, Golden, Colorado 80401-3393 303-275-3000 * www.nrel.gov Operated for the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy by Midwest Research Institute * Battelle

84

Answering Key Fuel Cycle Questions  

Science Conference Proceedings (OSTI)

The Advanced Fuel Cycle Initiative (AFCI) program has both outcome and process goals because it must address both waste already accumulating as well as completing the fuel cycle in connection with advanced nuclear power plant concepts. The outcome objectives are waste geological repository capacity and cost, energy security and sustainability, proliferation resistance, fuel cycle economics, and safety. The process objectives are readiness to proceed and adaptability and robustness in the face of uncertainties. A classic decision-making approach to such a multi-attribute problem would be to weight individual quantified criteria and calculate an overall figure of merit. This is inappropriate for several reasons. First, the goals are not independent. Second, the importance of different goals varies among stakeholders. Third, the importance of different goals is likely to vary with time, especially the energy future. Fourth, some key considerations are not easily or meaningfully quantifiable at present. Instead, at this point, we have developed 16 questions the AFCI program should answer and suggest an approach of determining for each whether relevant options improve meeting each of the program goals. We find that it is not always clear which option is best for a specific question and specific goal; this helps identify key issues for future work. In general, we suggest attempting to create as many win-win decisions (options that are attractive or neutral to most goals) as possible. Thus, to help clarify why the program is exploring the options it is, and to set the stage for future narrowing of options, we have developed 16 questions, as follows: What are the AFCI program goals? Which potential waste disposition approaches do we plan for? What are the major separations, transmutation, and fuel options? How do we address proliferation resistance? Which potential energy futures do we plan for? What potential external triggers do we plan for? Should we separate uranium? If we separate uranium, should we recycle it, store it or dispose of it? Is it practical to plan to fabricate and handle hot fuel? Which transuranic elements (TRU) should be separated and transmuted? Of those TRU separated, which should be transmuted together? Should we separate and/or transmute Cs and Sr isotopes that dominate near-term repository heating? Should we separate and/or transmute very long-lived Tc and I isotopes? Which separation technology? What mix of transmutation technologies? What fuel technology best supports the above decisions?

Steven J. Piet; Brent W. Dixon; J. Stephen Herring; David E. Shropshire; Mary Lou Dunzik-Gougar

2003-10-01T23:59:59.000Z

85

UNCORRECTEDPROOF Please cite this article in press as: Chen, H. et al., Nanonization strategies for poorly water-soluble drugs, Drug Discov Today (2010), doi:10.1016/j.drudis.2010.02.009  

E-Print Network (OSTI)

for poorly water-soluble drugs, Drug Discov Today (2010), doi:10.1016/j.drudis.2010.02.009 Drug Discovery Today Volume 00, Number 00 March 2010 REVIEWS Nanonization strategies for poorly water-soluble drugs and Technology, Wuhan 430074, China 3 CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety

Gao, Jinming

86

Proactive key management protocol for multicast services  

Science Conference Proceedings (OSTI)

A group key management is essential scheme guaranteeing data confidentiality in multicast. To provide the strict secrecy in group communication, the rekeying delay has to be minimized. In this paper, we propose a new group key management protocol, called ...

Dong-Hyun Je; Seung-Woo Seo

2009-06-01T23:59:59.000Z

87

On multi-column foreign key discovery  

Science Conference Proceedings (OSTI)

A foreign/primary key relationship between relational tables is one of the most important constraints in a database. From a data analysis perspective, discovering foreign keys is a crucial step in understanding and working with the data. Nevertheless, ...

Meihui Zhang; Marios Hadjieleftheriou; Beng Chin Ooi; Cecilia M. Procopiuc; Divesh Srivastava

2010-09-01T23:59:59.000Z

88

Light Sources Help Discover New Drug Against Melanoma | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma July 18, 2011 - 12:07pm Addthis The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. Mike Ross Science Writer at SLAC National Accelerator Laboratory What does this mean for me? A new drug designed to fight melanoma was discovered thanks to the

89

Cryptographic Key Managment Workshop 2012-A Draft ...  

Science Conference Proceedings (OSTI)

... Specify the key generation methods used Specify the random number generators used Specify ... primary and backup facilities ...

2012-09-11T23:59:59.000Z

90

Group-Based Authentication and Key Agreement  

Science Conference Proceedings (OSTI)

This paper presents an authentication and key agreement protocol to streamline communication activities for a group of mobile stations (MSs) roaming from the same home network (HN) to a serving network (SN). In such a roaming scenario, conventional schemes ... Keywords: Authentication and key agreement, Group key, Roaming, Security, Wireless network

Yu-Wen Chen; Jui-Tang Wang; Kuang-Hui Chi; Chien-Chao Tseng

2012-02-01T23:59:59.000Z

91

Molecular aptamers for drug delivery Weihong Tan1,2  

E-Print Network (OSTI)

University, Xiamen Fujian, 361005, China The active targeting of drugs in a cell-, tissue- or diseaseMolecular aptamers for drug delivery Weihong Tan1,2 , Hui Wang2 , Yan Chen1,2,3 , Xiaobing Zhang1, 410082, China 2 Center for Research at Bio/Nano Interface, Department of Chemistry, Department

Tan, Weihong

92

How molecular imaging is speeding up antiangiogenic drug development  

E-Print Network (OSTI)

How molecular imaging is speeding up antiangiogenic drug development Weibo Cai,1 Jianghong Rao,1 Sanjiv S. Gambhir,1,2 and Xiaoyuan Chen1 1 The Molecular Imaging Program at Stanford, Department. The shift in recent drug discovery to novel agents against specific molecular targets high- lights the need

Rao, Jianghong

93

DOE M 200.1-1 Chapter 9, Public Key Cryptography and Key Management  

Directives, Delegations, and Requirements

The use and management of certificate-based public key cryptography for the Department of Energy (DOE) requires the establishment of a public key ...

2000-02-15T23:59:59.000Z

94

Gastric H,K-ATPase as a drug target  

E-Print Network (OSTI)

cations. J Biol Chem Fukushima Y, Nakao M: Changes inChem 1980;255(16):7813-9. Fukushima Y, Post RL: Binding of

Shin, Jai M; Sachs, G

2006-01-01T23:59:59.000Z

95

Thailand-Key Results and Policy Recommendations for Future Bioenergy  

Open Energy Info (EERE)

and Policy Recommendations for Future Bioenergy and Policy Recommendations for Future Bioenergy Development Jump to: navigation, search Name Thailand-Key Results and Policy Recommendations for Future Bioenergy Development Agency/Company /Organization Food and Agriculture Organization of the United Nations Sector Land Focus Area Biomass, Agriculture Topics Co-benefits assessment, Policies/deployment programs, Background analysis Resource Type Lessons learned/best practices Website http://www.fao.org/docrep/013/ Country Thailand UN Region South-Eastern Asia References Thailand-Key Results and Policy Recommendations for Future Bioenergy Development[1] Abstract "The Government of Thailand, through its Alternative Energy Development Plan, has set a target to increase biofuel production to five billion

96

Magnetically attached sputter targets  

DOE Patents (OSTI)

An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

Makowiecki, D.M.; McKernan, M.A.

1994-02-15T23:59:59.000Z

97

T-571: Linux Kernel dns_resolver Key Processing Error Lets Local Users Deny  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1: Linux Kernel dns_resolver Key Processing Error Lets Local 1: Linux Kernel dns_resolver Key Processing Error Lets Local Users Deny Services T-571: Linux Kernel dns_resolver Key Processing Error Lets Local Users Deny Services March 7, 2011 - 3:05pm Addthis PROBLEM: Linux Kernel dns_resolver Key Processing Error Lets Local Users Deny Services. PLATFORM: Linux Kernel 2.6.37 and prior versions ABSTRACT: A vulnerability was reported in the Linux Kernel. A local user can cause denial of service conditions. reference LINKS: SecurityTracker Alert ID:1025162 Latest Stable Kernel CVE-2011-1076 IMPACT ASSESSMENT: High Discussion: When a DNS resolver key is instantiated with an error indication, a local user can attempt to read the key to trigger a null pointer dereference and cause a kernel crash. A local user can cause the target system to crash.

98

Quantum Key Distribution Protocol with User Authentication  

E-Print Network (OSTI)

We propose a quantum key distribution protocol with quantum based user authentication. User authentication is executed by validating the correlation of GHZ states. Alice and Bob can distribute a secure key using the remaining GHZ states after authentication. This secret key does not leak even to the arbitrator by the properties of the entanglement. We will show that our protocol is secure against the cloning attack.

Lee, H; Lee, D; Lim, J; Yang, H J; Lee, Hwayean; Lee, Sangjin; Lee, Donghoon; Lim, Jongin; Yang, HyungJin

2005-01-01T23:59:59.000Z

99

Unifying classical and quantum key distillation  

E-Print Network (OSTI)

Assume that two distant parties, Alice and Bob, as well as an adversary, Eve, have access to (quantum) systems prepared jointly according to a tripartite state ?ABE. In addition, Alice and Bob can use local operations and authenticated public classical communication. Their goal is to establish a key which is unknown to Eve. We initiate the study of this scenario as a unification of two standard scenarios: (i) key distillation (agreement) from classical correlations and (ii) key distillation from pure tripartite quantum states. Firstly, we obtain generalisations of fundamental results related to scenarios (i) and (ii), including upper bounds on the key rate, i.e., the number of key bits that can be extracted per copy of ?ABE. Moreover, based on an embedding of classical distributions into quantum states, we are able to find new connections between protocols and quantities in the standard scenarios (i) and (ii). Secondly, we study specific properties of key distillation protocols. In particular, we show that every protocol that makes use of pre-shared key can be transformed into an equally efficient protocol which needs no pre-shared key. This result is of practical significance as it applies to quantum key distribution (QKD) protocols, but it also implies that the key rate cannot be locked with information on Eves side. Finally, we exhibit an arbitrarily large separation between the key rate in the standard setting where Eve is equipped with quantum memory and the key rate in a setting where Eve is only given classical memory. This shows that assumptions on the nature of Eves memory are important in order to determine the correct security threshold in QKD. 1

Matthias Christ; Renato Renner

2008-01-01T23:59:59.000Z

100

Life-Changing Drug Design  

NLE Websites -- All DOE Office Websites (Extended Search)

facilities are aimed at designing more effective drugs with fewer side effects. Life-Changing Drug Design One notable example is vemurafenib, a drug designed by...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

A Key Enzyme to the Potency of an Anticancer Agent  

NLE Websites -- All DOE Office Websites (Extended Search)

A Key Enzyme to the Potency of an Anticancer Agent Print A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline 8.2.2, discovered and characterized the chlorinating SalL enzyme, a crucial component in sal A biosynthesis that uses a unique chlorine-activating mechanism. Chlorine-Loving Enzyme Speeds Things Up The smell of chlorine is unmistakable. It's in the swimming pool, in household bleach, and sometimes the faint odor of chlorine rises up from your tap water. But chlorine is more than a purifier and a disinfectant. It's found almost everywhere in nature-in table salt, dissolved in the ocean, and as a key ingredient in biosynthesis, a vital part of the metabolism of all living organisms.

102

Comment on "Quantum dense key distribution"  

E-Print Network (OSTI)

In this Comment we question the security of recently proposed by Degiovanni et al. [Phys. Rev. A 69 (2004) 032310] scheme of quantum dense key distribution.

Antoni Wojcik

2004-05-07T23:59:59.000Z

103

Cryptographic Key Management Workshop 2009 - A Holistic ...  

Science Conference Proceedings (OSTI)

... policies Board of Directors CEO Protect critical data CSO/CISO CIO We aren't ... Encrypted Database Management Encrypted Tape Key Management ...

2012-05-07T23:59:59.000Z

104

CODATA Key Values for Thermodynamics - TMS  

Science Conference Proceedings (OSTI)

Feb 8, 2007 ... This site includes internationally agreed upon values for thermodynamic properties of key chemical substances established by the Committee...

105

Nanomechanics: New Test Measures Key Properties of ...  

Science Conference Proceedings (OSTI)

Nanomechanics: New Test Measures Key Properties of ... Tests using the wrinkle-crack method, however, show ... to the longest duration tested, 10 days ...

2012-10-18T23:59:59.000Z

106

Quantum key distribution network with wavelength addressing  

E-Print Network (OSTI)

Most traditional applications of quantum cryptography are point-to-point communications, in which only two users can exchange keys. In this letter, we present a network scheme that enable quantum key distribution between multi-user with wavelength addressing. Considering the current state of wavelength division multiplexing technique, dozens or hundreds of users can be connected to such a network and directly exchange keys with each other. With the scheme, a 4-user demonstration network was built up and key exchanges were performed.

Mo, X F; Han, Z F; Xu, F X; Zhang, T; Guo, Guang-Can; Han, Zheng-Fu; Mo, Xiao-Fan; Xu, Fang-Xing; Zhang, Tao

2006-01-01T23:59:59.000Z

107

New Quantum Key System Combines Speed, Distance  

Science Conference Proceedings (OSTI)

... a prototype high-speed quantum key distribution (QKD) system ... a theoretically unbreakable one-time pad encryption, transmission and decryption ...

2013-07-08T23:59:59.000Z

108

Two key questions about color superconductivity.  

E-Print Network (OSTI)

??We pose two key questions about color superconductivity: What are the effects of the large strange quark mass, and what are the observable consequences of (more)

Kundu, Joydip, 1977-

2004-01-01T23:59:59.000Z

109

Schedules of Key Environmental Impact Statements  

Energy.gov (U.S. Department of Energy (DOE))

This document graphically displays the milestone dates and projected schedules of key Environmental Impact Statements (updated monthly).This chart represents anticipated activity and is not a...

110

BIASED RANDOM-KEY GENETIC ALGORITHMS WITH ...  

E-Print Network (OSTI)

Handbook of Metaheuristics. Kluwer. Academic Publishers, 2003. J.F. Gonalves and M.G.C. Resende. Biased random-key genetic algorithms for combinatorial...

111

Design and Analysis of Key Comparisons  

Science Conference Proceedings (OSTI)

... new methods, and make statistically best practices available ... to Key Comparisons such as data reporting and ... In the big picture, with the lowering ...

2010-11-18T23:59:59.000Z

112

Identity-based authenticated asymmetric group key agreement protocol  

Science Conference Proceedings (OSTI)

In identity-based public-key cryptography, an entity's public key can be easily derived from its identity. The direct derivation of public keys in identity-based public-key cryptography eliminates the need for certificates and solves certain public key ... Keywords: asymmetric group key agreement, bilinear map, group key agreement, identity-based public-key cryptography

Lei Zhang; Qianhong Wu; Bo Qin; Josep Domingo-Ferrer

2010-07-01T23:59:59.000Z

113

U-008: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

08: Symantec Data Loss Prevention Bugs in KeyView Filter Lets 08: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote Users Deny Service U-008: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote Users Deny Service October 11, 2011 - 8:00am Addthis PROBLEM: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote Users Deny Service PLATFORM: Symantec Data Loss Prevention Enforce/Detection Servers for Windows 10.x, 11.x ABSTRACT: A remote user can create a file that, when processed by the target filter, will cause partial denial of service conditions. reference LINKS: Symantec Security Advisory SYM11-013 SecurityTracker Alert ID: 1026157 IMPACT ASSESSMENT: Medium Discussion: Multiple vulnerabilities were reported in Symantec Data Loss Prevention. A remote user can cause denial of service conditions on the target system.A

114

Unifying classical and quantum key distillation  

E-Print Network (OSTI)

Assume that two distant parties, Alice and Bob, as well as an adversary, Eve, have access to (quantum) systems prepared jointly according to a tripartite state. In addition, Alice and Bob can use local operations and authenticated public classical communication. Their goal is to establish a key which is unknown to Eve. We initiate the study of this scenario as a unification of two standard scenarios: (i) key distillation (agreement) from classical correlations and (ii) key distillation from pure tripartite quantum states. Firstly, we obtain generalisations of fundamental results related to scenarios (i) and (ii), including upper bounds on the key rate. Moreover, based on an embedding of classical distributions into quantum states, we are able to find new connections between protocols and quantities in the standard scenarios (i) and (ii). Secondly, we study specific properties of key distillation protocols. In particular, we show that every protocol that makes use of pre-shared key can be transformed into an equally efficient protocol which needs no pre-shared key. This result is of practical significance as it applies to quantum key distribution (QKD) protocols, but it also implies that the key rate cannot be locked with information on Eve's side. Finally, we exhibit an arbitrarily large separation between the key rate in the standard setting where Eve is equipped with quantum memory and the key rate in a setting where Eve is only given classical memory. This shows that assumptions on the nature of Eve's memory are important in order to determine the correct security threshold in QKD.

Matthias Christandl; Artur Ekert; Michal Horodecki; Pawel Horodecki; Jonathan Oppenheim; Renato Renner

2006-08-25T23:59:59.000Z

115

Targets for Precision Measurements  

E-Print Network (OSTI)

The general properties needed in targets (sources) for high precision, high accuracy measurements are reviewed. The application of these principles to the problem of developing targets for the Fission TPC is described. Longer term issues, such as the availability of actinide materials, improved knowledge of energy losses and straggling and the stability of targets during irradiation are also discussed.

W. Loveland; L. Yao; David M. Asner; R. G. Baker; J. Bundgaard; E. Burgett; M. Cunningham; J. Deaven; D. L. Duke; U. Greife; S. Grimes; M. Heffer; T. Hill; D. Isenhower; J. L. Klay; V. Kleinrath; N. Kornilov; A. B. Laptev; T. N. Massey; R. Meharchand; H. Qu; J. Ruz; S. Sangiorgio; B. Selhan; L. Snyder; S. Stave; G. Tatishvili; R. T. Thornton; F. Tovesson; D. Towell; R. S. Towell; S. Watson; B. Wendt; L. Wood

2013-03-09T23:59:59.000Z

116

General model of quantum key distribution  

E-Print Network (OSTI)

A general mathematical framework for quantum key distribution based on the concepts of quantum channel and Turing machine is suggested. The security for its special case is proved. The assumption is that the adversary can perform only individual (in essence, classical) attacks. For this case an advantage of quantum key distribution over classical one is shown.

A. S. Trushechkin; I. V. Volovich

2005-04-20T23:59:59.000Z

117

General quantum key distribution in higher dimension  

E-Print Network (OSTI)

We study a general quantum key distribution protocol in higher dimension. In this protocol, quantum states in arbitrary g+1 (1?g?d) out of all d+1 mutually unbiased bases in a d-dimensional system can be used for the key ...

Shi, Han-Duo

118

Robust key extraction from physical uncloneable functions  

Science Conference Proceedings (OSTI)

Physical Uncloneable Functions (PUFs) can be used as a cost-effective means to store key material in an uncloneable way. Due to the fact that the key material is obtained by performing measurements on a physical system, noise is inevitably present in ... Keywords: authentication, challenge-response pair, error correction, noise, physical uncloneable function, speckle pattern

B. kori?; P. Tuyls; W. Ophey

2005-06-01T23:59:59.000Z

119

residential sector key indicators | OpenEI  

Open Energy Info (EERE)

residential sector key indicators residential sector key indicators Dataset Summary Description This dataset is the 2009 United States Residential Sector Key Indicators and Consumption, part of the Source EIA Date Released March 01st, 2009 (5 years ago) Date Updated Unknown Keywords AEO consumption EIA energy residential sector key indicators Data application/vnd.ms-excel icon 2009 Residential Sector Key Indicators and Consumption (xls, 55.3 KiB) Quality Metrics Level of Review Peer Reviewed Comment Temporal and Spatial Coverage Frequency Annually Time Period License License Open Data Commons Public Domain Dedication and Licence (PDDL) Comment http://www.eia.gov/abouteia/copyrights_reuse.cfm Rate this dataset Usefulness of the metadata Average vote Your vote Usefulness of the dataset Average vote Your vote

120

Fuel Cell Technologies Office: Key Activities  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Activities Key Activities The Fuel Cell Technologies Office conducts work in several key areas to advance the development and commercialization of hydrogen and fuel cell technologies. Research, Development, and Demonstration Key areas of research, development, and demonstration (RD&D) include the following: Fuel Cell R&D, which seeks to improve the durability, reduce the cost, and improve the performance of fuel cell systems, through advances in fuel cell stack and balance of plant components Hydrogen Fuel R&D, which focuses on enabling the production of low-cost hydrogen fuel from diverse renewable pathways and addressing key challenges to hydrogen delivery and storage Manufacturing R&D, which works to develop and demonstrate advanced manufacturing technologies and processes that will reduce the cost of fuel cell systems and hydrogen technologies

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion  

E-Print Network (OSTI)

, Changchun 130000, China; d Department of Ophthalmology, Harbin Medical University, The Second Affiliated Hospital, Harbin, Heilongjiang 150086, China; e National Center for Advancing Translational Sciences targets for the development of neuroprotective drugs, we developed a high-throughput RNA in- terference

Dong, Xinzhong

122

Captured key electrical safety lockout system  

DOE Patents (OSTI)

A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member's second position corresponds to the preselected position at which the key can be removed from and inserted into the lock.

Darimont, Daniel E. (Aurora, IL)

1995-01-01T23:59:59.000Z

123

Anti-counterfeiting, key distribution, and key storage in an ambient world via physical unclonable functions  

Science Conference Proceedings (OSTI)

Virtually all applications which provide or require a security service need a secret key. In an ambient world, where (potentially) sensitive information is continually being gathered about us, it is critical that those keys be both securely deployed ... Keywords: Fuzzy extractor, Helper data algorithm, Intrinsic PUF, Key distribution, LC-PUFs, Physical unclonable functions, SRAMs, Sensor nodes

Jorge Guajardo; Boris kori?; Pim Tuyls; Sandeep S. Kumar; Thijs Bel; Antoon H. Blom; Geert-Jan Schrijen

2009-03-01T23:59:59.000Z

124

Optically generated ultrasound for enhanced drug delivery  

DOE Patents (OSTI)

High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

2002-01-01T23:59:59.000Z

125

Key Elements of and Materials Performance Targets for Highly Insulating Window Frames  

E-Print Network (OSTI)

D. Curcija. 2006. THERM 5.2 / WINDOW 5.2, NFRC SimulationSashlite 2011. The Shashlite window website http://2010. Development of a slim window frame made of glass fibre

Gustavsen, Arild

2012-01-01T23:59:59.000Z

126

Target Database | Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Science & Engineering Applications Target Database The Target database and analytical pipeline provides bioinformatics support and selection of protein targets of biomedical...

127

Composite keys? | OpenEI Community  

Open Energy Info (EERE)

Composite keys? Composite keys? Home > Groups > Databus Does DataBus support using composite keys in a Table definition? If not, is there a way to automatically generate a unique value for each entry that is uploaded? Submitted by Hopcroft on 5 September, 2013 - 17:13 1 answer Points: 0 At this time, no, and no way to generate unique key either right now. You can submit a feature request for this though on github. thanks, Dean Deanhiller on 6 September, 2013 - 06:58 Groups Menu You must login in order to post into this group. Recent content Go to My Databus->Data Streams... yes, it is done the same way y... Update rows? How to use streaming chart? if you are an administrator, s... more Group members (6) Managers: Deanhiller Recent members: Hopcroft Vikasgoyal Ksearight NickL

128

Two key questions about color superconductivity  

E-Print Network (OSTI)

We pose two key questions about color superconductivity: What are the effects of the large strange quark mass, and what are the observable consequences of color superconductivity? Motivated by the first question, we study ...

Kundu, Joydip, 1977-

2004-01-01T23:59:59.000Z

129

Password based key exchange with mutual authentication  

Science Conference Proceedings (OSTI)

A reasonably efficient password based key exchange (KE) protocol with provable security without random oracle was recently proposed by Katz, et al. [17] and later by Gennaro and Lindell [13]. However, these protocols do not support mutual authentication ...

Shaoquan Jiang; Guang Gong

2004-08-01T23:59:59.000Z

130

Cryptographic Key Management Project - Comments on the ...  

Science Conference Proceedings (OSTI)

... planned digital signature lifetime (based on the key strength ... Will the CAVP provide a standalone DH test that ... for about an eighth of the cost of 2.5 ...

2012-05-07T23:59:59.000Z

131

Jurisdiction Members Contact Info Key Staffers  

E-Print Network (OSTI)

Relevant Jurisdiction Members Contact Info Key Staffers House Science, Space, and Technology, aeronautics, civil aviation, environment, and marine science · America COMPETES · Energy labs · National Science Foundation, including NCAR · National Aeronautics and Space Administration · National Weather

132

Some key Y-12 General Foremen remembered  

NLE Websites -- All DOE Office Websites (Extended Search)

expanded from K-25 to Y-12 and X-10, they brought their management style with them. Clark Center was a key individual. Clark Center Park, still known by old timers as "Carbide...

133

HYDROGEN ISOTOPE TARGETS  

DOE Patents (OSTI)

The design of targets for use in the investigation of nuclear reactions of hydrogen isotopes by bombardment with accelerated particles is described. The target con struction eomprises a backing disc of a metal selected from the group consisting of molybdenunn and tungsten, a eoating of condensed titaniunn on the dise, and a hydrogen isotope selected from the group consisting of deuterium and tritium absorbed in the coatiag. The proeess for preparing these hydrogen isotope targets is described.

Ashley, R.W.

1958-08-12T23:59:59.000Z

134

Quantum Key Distribution Using Quantum Faraday Rotators  

E-Print Network (OSTI)

We propose a new quantum key distribution (QKD) protocol based on the fully quantum mechanical states of the Faraday rotators. The protocol is unconditionally secure against eavesdropping for single-photon source on a noisy environment and robust against impersonation attacks. It also allows for unconditionally secure key distribution for multiphoton source up to two photons. The protocol could be implemented experimentally with the current spintronics technology on semiconductors.

Choi, T; Choi, Mahn-Soo; Choi, Taeseung

2006-01-01T23:59:59.000Z

135

Multipartite secret key distillation and bound entanglement  

Science Conference Proceedings (OSTI)

Recently it has been shown that quantum cryptography beyond pure entanglement distillation is possible and a paradigm for the associated protocols has been established. Here we systematically generalize the whole paradigm to the multipartite scenario. We provide constructions of new classes of multipartite bound entangled states, i.e., those with underlying twisted Greenberger-Horne-Zeilinger (GHZ) structure and nonzero distillable cryptographic key. We quantitatively estimate the key from below with the help of the privacy squeezing technique.

Augusiak, Remigiusz; Horodecki, Pawel [Faculty of Applied Physics and Mathematics, Gdansk University of Technology, Narutowicza 11/12, 80-952 Gdansk (Poland) and ICFO-Institute Ciencies Fotoniques, Mediterranean Technology Park, 08860 Castelldefels (Barcelona) (Spain); Faculty of Applied Physics and Mathematics, Gdansk University of Technology, Narutowicza 11/12, 80-952 Gdansk (Poland)

2009-10-15T23:59:59.000Z

136

Target Cost Management Strategy  

E-Print Network (OSTI)

Target cost management (TCM) is an innovation of Japanese management accounting system and by common sense has been considered with great interest by practitioners. Nowadays, TCM related

Okano, Hiroshi

1996-01-01T23:59:59.000Z

137

High Efficient Secret Key Distillation for Long Distance Continuous Variable Quantum Key Distribution  

E-Print Network (OSTI)

The continuous variable quantum key distribution is expected to provide high secret key rate without single photon source and detector, but the lack of the secure and effective key distillation method makes it unpractical. Here, we present a secure single-bit-reverse-reconciliation protocol combined with secret information concentration and post-selection, which can distill the secret key with high efficiency and low computational complexity. The simulation results show that this protocol can provide high secret key rate even when the transmission fiber is longer than 150km, which may make the continuous variable scheme to outvie the single photon one.

Yi-bo Zhao; Zheng-fu Han; Jin-jian Chen; You-zhen Gui; Guang-can Guo

2006-03-08T23:59:59.000Z

138

Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens  

Science Conference Proceedings (OSTI)

Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals, including AIDS patients and transplant recipients. Few antifungals can treat C. neoformans infections, and drug resistance is increasing. Protein farnesyltransferase (FTase) catalyzes post-translational lipidation of key signal transduction proteins and is essential in C. neoformans. We present a multidisciplinary study validating C. neoformans FTase (CnFTase) as a drug target, showing that several anticancer FTase inhibitors with disparate scaffolds can inhibit C. neoformans and suggesting structure-based strategies for further optimization of these leads. Structural studies are an essential element for species-specific inhibitor development strategies by revealing similarities and differences between pathogen and host orthologs that can be exploited. We, therefore, present eight crystal structures of CnFTase that define the enzymatic reaction cycle, basis of ligand selection, and structurally divergent regions of the active site. Crystal structures of clinically important anticancer FTase inhibitors in complex with CnFTase reveal opportunities for optimization of selectivity for the fungal enzyme by modifying functional groups that interact with structurally diverse regions. A substrate-induced conformational change in CnFTase is observed as part of the reaction cycle, a feature that is mechanistically distinct from human FTase. Our combined structural and functional studies provide a framework for developing FTase inhibitors to treat invasive fungal infections.

Hast, Michael A.; Nichols, Connie B.; Armstrong, Stephanie M.; Kelly, Shannon M.; Hellinga, Homme W.; Alspaugh, J. Andrew; Beese, Lorena S. (Duke)

2012-09-17T23:59:59.000Z

139

NIST Special Publication 800-57, Recommendation for Key ...  

Science Conference Proceedings (OSTI)

... keying material from key backup or archive. ... term random number generator (RNG) is ... Deterministic Random Bit Generators (DRBGs), sometimes ...

2012-07-10T23:59:59.000Z

140

ITL Bulletin Generating Secure Cryptographic Keys: A Critical ...  

Science Conference Proceedings (OSTI)

... KEYS: A CRITICAL COMPONENT OF CRYPTOGRAPHIC ... relies upon two basic components: an algorithm (or ... and of keys for symmetric algorithms. ...

2013-04-16T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

A secure multiple-agent cryptographic key recovery system  

Science Conference Proceedings (OSTI)

Symmetric cryptography uses the same session key for message encryption and decryption. Without having it, the encrypted message will never be revealed. In case the session key is unavailable or government authorities need to inspect suspect messages, ... Keywords: key recovery, key recovery agent, key recovery center, secret sharing, session key

Kanokwan Kanyamee; Chanboon Sathitwiriyawong

2009-08-01T23:59:59.000Z

142

STGWG Key Outcomes for May 3, 2010  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Key Outcomes-Nashville 2010 Page 1 Key Outcomes-Nashville 2010 Page 1 State and Tribal Government Working Group (STGWG) Nashville, Tennessee - May 3, 2010 KEY OUTCOMES OVERVIEW Members appreciated the participation of all DOE officials at the STGWG meeting in Nashville, and are especially appreciative of the participation of high-level DOE management, such as Sky Gallegos, Deputy Assistant Secretary of the Office of Congressional and Intergovernmental Affairs, and Frank Marcinowski, Acting Chief Technical Officer and Deputy Assistant Secretary for Technical and Regulatory Support. Such participation demonstrates a continuing commitment to improve interaction with tribes and states. STGWG looks forward to our next Intergovernmental meeting with DOE in the fall. FULL STGWG ISSUES

143

Composite keys? | OpenEI Community  

Open Energy Info (EERE)

Composite keys? Home > Groups > Databus Does DataBus support using composite keys in a Table definition? If not, is there a way to automatically generate a unique value for each entry that is uploaded? Submitted by Hopcroft on 5 September, 2013 - 17:13 1 answer Points: 0 At this time, no, and no way to generate unique key either right now. You can submit a feature request for this though on github. thanks, Dean Deanhiller on 6 September, 2013 - 06:58 Groups Menu You must login in order to post into this group. Recent content Go to My Databus->Data Streams... yes, it is done the same way y... Update rows? How to use streaming chart? if you are an administrator, s... more Group members (7) Managers: Deanhiller Recent members: Bradmin Hopcroft Vikasgoyal Ksearight

144

Public key infrastructure for DOE security research  

SciTech Connect

This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

Aiken, R.; Foster, I.; Johnston, W.E. [and others

1997-06-01T23:59:59.000Z

145

Nonorthogonal decoy-state Quantum Key Distribution  

E-Print Network (OSTI)

In practical quantum key distribution (QKD), weak coherent states as the photon sources have a limit in secure key rate and transmission distance because of the existence of multiphoton pulses and heavy loss in transmission line. Decoy states method and nonorthogonal encoding protocol are two important weapons to combat these effects. Here, we combine these two methods and propose a efficient method that can substantially improve the performance of QKD. We find a 79 km increase in transmission distance over the prior record using decoy states method.

Li, J B; Li, Jing-Bo; Fang, Xi-Ming

2005-01-01T23:59:59.000Z

146

Complementarity, distillable secret key, and distillable entanglement  

E-Print Network (OSTI)

We consider controllability of two conjugate observables Z and X by two parties with classical communication. The ability is specified by two alternative tasks, (i) agreement on Z and (ii) preparation of an eigenstate of X with use of an extra communication channel. We prove that their feasibility is equivalent to that of key distillation if the extra channel is quantum, and to that of entanglement distillation if it is classical. This clarifies the distinction between two entanglement measures, distillable key and distillable entanglement.

Masato Koashi

2007-04-27T23:59:59.000Z

147

The design and characterization of a microcalorimeter to aid drug discovery  

E-Print Network (OSTI)

This thesis describes the design and characterization of a microcalorimeter used to aid drug discovery. There are four key functional requirements for the device: (1.) 8.4 [mu]J energy resolution, (2.) 20 [mu]L reactant ...

McEuen, Scott Jacob

2008-01-01T23:59:59.000Z

148

Quantum repeaters and quantum key distribution: the impact of entanglement distillation on the secret key rate  

E-Print Network (OSTI)

We investigate quantum repeaters in the context of quantum key distribution. We optimize the secret key rate per memory per second with respect to different distillation protocols and distillation strategies. For this purpose, we also derive an analytical expression for the average number of entangled pairs created by the quantum repeater, including classical communication times for entanglement swapping and entanglement distillation. We investigate the impact of this classical communication time on the secret key rate. We finally study the effect of the detector efficiency on the secret key rate.

Sylvia Bratzik; Silvestre Abruzzo; Hermann Kampermann; Dagmar Bru

2013-03-14T23:59:59.000Z

149

Structural Biology Helps Drug Discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Biology Helps Drug Discovery Print Last year, drug discovery company Plexxikon made front-page news with its highly successful anti-cancer drug, Zelboraf, a product that...

150

Structural Biology Helps Drug Discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Biology Helps Drug Discovery Structural Biology Helps Drug Discovery Print Thursday, 19 July 2012 11:21 Last year, drug discovery company Plexxikon made front-page news...

151

A Key to Drought Resistant Crops | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

work in molecular detail, which can then help drug developers engineer more potent drugs that have fewer unwanted side effects. Although it later resulted that the abscisic...

152

Key issues of RFID reader network system  

Science Conference Proceedings (OSTI)

RFID system is used widely in different applications and comes in a myriad of forms today. It is doomed to be concerned by people and still be the hot spot of research in the next few years. In this paper, Key issues of RFID reader network system are ... Keywords: RFID, WSN, anti-collision algorithm, taxonomy

Leian Liu; Dashun yan; Jiapei Wu; Hongjiang Wang

2009-09-01T23:59:59.000Z

153

Key Management Challenges in Smart Grid  

Science Conference Proceedings (OSTI)

Agenda Awarded in February 2011 Team of industry and research organizations Project Objectives Address difficult issues Complexity Diversity of systems Scale Longevity of solution Participate in standards efforts and working groups Develop innovative key management solutions Modeling and simulation ORNL Cyber Security Econometric Enterprise System Demonstrate effectiveness of solution Demonstrate scalability

Sheldon, Frederick T [ORNL; Duren, Mike [Sypris Electronics, LLC

2012-01-01T23:59:59.000Z

154

Target | Open Energy Information  

Open Energy Info (EERE)

Target Target Jump to: navigation, search Name Target Address 1000 Nicollet Mall Place Minneapolis, MN Zip 55440 Website http://www.target.com Coordinates 44.9739366°, -93.2750493° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":44.9739366,"lon":-93.2750493,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

155

Multiple shell fusion targets  

DOE Patents (OSTI)

Multiple shell fusion targets for use with electron beam and ion beam implosion systems are described. The multiple shell targets are of the low-power type and use a separate relatively low Z, low density ablator at large radius for the outer shell, which reduces the focusing and power requirements of the implosion system while maintaining reasonable aspect ratios. The targets use a high Z, high density pusher shell placed at a much smaller radius in order to obtain an aspect ratio small enough to protect against fluid instability. Velocity multiplication between these shells further lowers the power requirements. Careful tuning of the power profile and intershell density results in a low entropy implosion which allows breakeven at low powers. For example, with ion beams as a power source, breakeven at 10-20 Terrawatts with 10 MeV alpha particles for imploding a multiple shell target can be accomplished.

Lindl, J.D.; Bangerter, R.O.

1975-10-31T23:59:59.000Z

156

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo  

E-Print Network (OSTI)

Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% of all cancers today. ...

Dhar, Shanta

157

A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy  

E-Print Network (OSTI)

The use of nanotechnology to engineer drug delivery vehicles comprised of controlled release polymers with targeting molecules has the potential to revolutionize cancer therapy, among other diseases. Although a myriad of ...

Valencia, Pedro M. (Pedro Miguel)

2013-01-01T23:59:59.000Z

158

Pilot study of inhaled aerosols targeted via magnetic alignment of high aspect ratio particles in rabbits  

Science Conference Proceedings (OSTI)

Recently, inhaled pharmaceutical aerosols have seen increased investigation in the treatment of lung cancer, where the inability to deliver adequate therapeutic drug concentrations to tumour sites may be overcome with improved targeted delivery to the ...

Gillian E. S. Redman; Andrew R. Martin; Paul Waszak; Richard B. Thompson; Po-Yin Cheung; Bernard Thbaud; Warren H. Finlay

2011-01-01T23:59:59.000Z

159

Argus target chamber  

SciTech Connect

A target chamber for application in the laser fusion program must satisfy some very basic requirements. (1) Provide a vacuum on the order of 10$sup -6$ torr. (2) Support a microscopically small target in a fixed point in space and verify its location within 5 micrometers. (3) Contain an adjustable beam focusing system capable of delivering a number of laser beams onto the target simultaneously, both in time and space. (4) Provide access for diagnostics to evaluate the results of target irradiation. (5) Have flexibility to allow changes in targets, focusing optics and number of beams. The ARGUS laser which is now under construction at LLL will have a target chamber which meets these requirements in a simple economic manner. The chamber and auxiliary equipment are described, with reference to two double beam focusing systems; namely, lenses and ellipsoidal mirrors. Provision is made for future operation with four beams, using ellipsoidal mirrors for two-sided illumination and lens systems for tetragonal and tetrahedral irradiation. (auth)

Rienecker, F. Jr.; Glaros, S.S.; Kobierecki, M.

1975-11-12T23:59:59.000Z

160

Accountable key infrastructure (AKI): a proposal for a public-key validation infrastructure  

Science Conference Proceedings (OSTI)

Recent trends in public-key infrastructure research explore the tradeoff between decreased trust in Certificate Authorities (CAs), resilience against attacks, communication overhead (bandwidth and latency) for setting up an SSL/TLS connection, and availability ... Keywords: accountability, certificate validation, public log servers, public-key infrastructure, ssl, tls

Tiffany Hyun-Jin Kim, Lin-Shung Huang, Adrian Perring, Collin Jackson, Virgil Gligor

2013-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Neutronic Characterization of the Megapie Target  

E-Print Network (OSTI)

The MEGAPIE project is one of the key experiments towards the feasibility of Accelerator Driven Systems. On-line operation and post-irradiation analysis will provide the scientific community with unique data on the behavior of a liquid spallation target under realistic irradiation conditions. A good neutronics performance of such a target is of primary importance towards an intense neutron source, where an extended liquid metal loop requires some dedicated verifications related to the delayed neutron activity of the irradiated PbBi. In this paper we report on the experimental characterization of the MEGAPIE neutronics in terms of the prompt neutron (PN) flux inside the target and the delayed neutron (DN) flux on the top of it. For the PN measurements, a complex detector, made of 8 microscopic fission chambers, has been built and installed in the central part of the target to measure the absolute neutron flux and its spatial distribution. Moreover, integral information on the neutron energy distribution as a function of the position along the beam axis could be extracted, providing integral constraints on the neutron production models implemented in transport codes such as MCNPX. For the DN measurement, we used a standard 3He counter and we acquired data during the start-up phase of the target irradiation in order to take sufficient statistics at variable beam power. Experimental results obtained on the PN flux characteristics and their comparison with MCNPX simulations are presented, together with a preliminary analysis of the DN decay time spectrum.

Stefano Panebianco; Olivier Bringer; Pavel Bokov; Sebastien Chabod; Frederic Chartier; Emmeric Dupont; Diane Dore; Xavier Ledoux; Alain Letourneau; Ludovic Oriol; Aurelien Prevost; Danas Ridikas; Jean-Christian Toussaint

2007-10-31T23:59:59.000Z

162

Leakage resilient strong key-insulated signatures in public channel  

Science Conference Proceedings (OSTI)

Key-insulation aims at minimizing (i.e., compartmentalizing) the damage of users from key exposures, and traditionally requires a private channel of communication between a user and a semi-trusted party called a helper to refresh the private keys. The ... Keywords: continual key leakage, key-insulation, public channel, signatures

Le Trieu Phong; Shin'ichiro Matsuo; Moti Yung

2010-12-01T23:59:59.000Z

163

Key Facts: Solyndra Solar | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

You are here You are here Home » Key Facts: Solyndra Solar Key Facts: Solyndra Solar On September 1, 2011, Solyndra, a solar energy start-up and recipient of an Energy Department loan guarantee, declared bankruptcy. While this event is deeply disappointing, at the time the loan guarantee was issued, Solyndra was widely seen as a promising and innovative company: Solyndra was named one of the world's "50 Most Innovative Companies" in 2010 by MIT's Technology Review and included in the Wall Street Journal's "The Next Big Thing: Top 50 Venture Backed Companies." Private investors, after conducting their own careful review of Solyndra, put $1 billion of their own private capital behind the company. Solyndra reported sales growth of 40% from 2009 to 2010, from $100

164

Practical Decoy State for Quantum Key Distribution  

E-Print Network (OSTI)

Decoy states have recently been proposed as a useful method for substantially improving the performance of quantum key distribution. Here, we present a general theory of the decoy state protocol based on only two decoy states and one signal state. We perform optimization on the choice of intensities of the two decoy states and the signal state. Our result shows that a decoy state protocol with only two types of decoy states--the vacuum and a weak decoy state--asymptotically approaches the theoretical limit of the most general type of decoy state protocols (with an infinite number of decoy states). We also present a one-decoy-state protocol. Moreover, we provide estimations on the effects of statistical fluctuations and suggest that, even for long distance (larger than 100km) QKD, our two-decoy-state protocol can be implemented with only a few hours of experimental data. In conclusion, decoy state quantum key distribution is highly practical.

X. Ma; B. Qi; Y. Zhao; H. -K. Lo

2005-03-01T23:59:59.000Z

165

Key Physical Mechanisms in Nanostructured Solar Cells  

DOE Green Energy (OSTI)

The objective of the project was to study both theoretically and experimentally the excitation, recombination and transport properties required for nanostructured solar cells to deliver energy conversion efficiencies well in excess of conventional limits. These objectives were met by concentrating on three key areas, namely, investigation of physical mechanisms present in nanostructured solar cells, characterization of loss mechanisms in nanostructured solar cells and determining the properties required of nanostructured solar cells in order to achieve high efficiency and the design implications.

Dr Stephan Bremner

2010-07-21T23:59:59.000Z

166

Assessment of ion-selective optical nanosensors for drug screening applications  

E-Print Network (OSTI)

Ion channels represent an important category of drug targets. They play a significant role in numerous physiological functions, from membrane excitation and signaling to fluid absorption and secretion. An ion-channel assay ...

Yun, Hannah

2007-01-01T23:59:59.000Z

167

Method for encryption and transmission of digital keying data  

DOE Patents (OSTI)

A method for the encryption, transmission, and subsequent decryption of digital keying data. The method utilizes the Data Encryption Standard and is implemented by means of a pair of apparatus, each of which is selectable to operate as either a master unit or remote unit. Each unit contains a set of key encryption keys which are indexed by a common indexing system. The master unit operates upon command from the remote unit to generate a data encryption key and encrypt the data encryption key using a preselected key encryption key. The encrypted data encryption key and an index designator are then downloaded to the remote unit, where the data encryption key is decrypted for subsequent use in the encryption and transmission data. Downloading of the encrypted data encryption key enables frequent change of keys without requiring manual entry or storage of keys at the remote unit.

Mniszewski, Susan M. (Los Alamos, NM); Springer, Edward A. (Los Alamos, NM); Brenner, David P. (North Collins, NY)

1988-01-01T23:59:59.000Z

168

PKM: a pairwise key management scheme for wireless sensor networks  

Science Conference Proceedings (OSTI)

Sensor networks are characterized by strict resource limitations and large scalability. Many sensor network applications require secure communication, a crucial component, especially in harsh environments. Symmetric key cryptography is very attractive ... Keywords: key distribution, key management, security, sensor networks

F. An; X. Cheng; J. M. Rivera; J. Li; Z. Cheng

2005-08-01T23:59:59.000Z

169

Foam encapsulated targets  

SciTech Connect

Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

1983-01-01T23:59:59.000Z

170

Proceedings of the workshop on polarized targets in storage rings  

Science Conference Proceedings (OSTI)

Polarization phenomena have played an increasingly important part in the study of nuclei and nucleons in recent years. Polarization studies have been hampered by the relatively few and rather fragile polarized targets which are presently available. The concept of polarized gas targets in storage rings opens a much wider range of possibilities than is available in the external target geometry. This novel method will represent a considerable advance in nuclear physics and will continue to receive much attention in plans for future facilities. An internal, polarized-target station is being planned for the cooler ring at the Indiana University Cyclotron Facility. Internal targets are compatible with recent designs of electron accelerators proposed by the Massachusetts Institute of Technology and the Southeastern Universities Research Association. The key to nuclear-science programs based on internal targets pivots on recent developments in polarized atomic beam methods, which include the more recent laser-driven polarized targets. The workshop drew together a unique group of physicists in the fields of high-energy, nuclear and atomic physics. The meeting was organized in a manner that stimulated discussion among the 58 participants and focused on developments in polarized target technology and the underlying atomic physics. An impressive array of future possibilities for polarized targets as well as current developments in polarized target technology were discussed at the workshop. Abstracts of individual items from the workshop were prepared separately for the data base.

Holt, R.J. (ed.)

1984-08-01T23:59:59.000Z

171

Key Renewable Energy Opportunities for Oklahoma Tribes | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Key Renewable Energy Opportunities for Oklahoma Tribes Key Renewable Energy Opportunities for Oklahoma Tribes August 13, 2012 Oklahoma City, Oklahoma Cox Convention Center The...

172

Single, Key Gene Discovery Could Streamline Production of Biofuels...  

NLE Websites -- All DOE Office Websites (Extended Search)

Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels August 11, 2011 - 3:51pm Addthis WASHINGTON,...

173

Vehicle Electrification is Key to Reducing Petroleum Dependency...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Vehicle Electrification is Key to Reducing Petroleum Dependency and Greenhouse Gas Emission Vehicle Electrification is Key to Reducing Petroleum Dependency and Greenhouse Gas...

174

Building Technologies Office: Key Activities in Energy Efficiency  

NLE Websites -- All DOE Office Websites (Extended Search)

Energy Efficiency to someone by E-mail Share Building Technologies Office: Key Activities in Energy Efficiency on Facebook Tweet about Building Technologies Office: Key Activities...

175

Energy: Critical Infrastructure and Key Resources Sector-Specific...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Energy: Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) Energy: Critical Infrastructure and Key...

176

Energy Critical Infrastructure and Key Resources Sector-Specific...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Energy Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) Energy Critical Infrastructure and Key...

177

Technology Key to Harnessing Natural Gas Potential | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Key to Harnessing Natural Gas Potential Technology Key to Harnessing Natural Gas Potential July 18, 2012 - 3:52pm Addthis Deputy Secretary Daniel Poneman tours Proinlosa Energy...

178

NIST SP 800-57, Recommendation for Key Management ...  

Science Conference Proceedings (OSTI)

... service use a hash function as a component of the ... mitigated by splitting the key into components that are ... a. When a symmetric key is used only for ...

2012-12-12T23:59:59.000Z

179

NERSC Played Key Role in Nobel Laureate's Discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Played Key Role in Nobel Laureate's Discovery NERSC Played Key Role in Nobel Laureate's Discovery NERSC, Berkeley Lab Now Centers for Computational Cosmology Community October 4,...

180

TEC Working Group Topic Groups Rail Key Documents Planning Subgroup...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Rail Key Documents Planning Subgroup TEC Working Group Topic Groups Rail Key Documents Planning Subgroup Planning Subgroup Rail Planning Timeline Benchmarking Project: AREVA Trip...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Targeted radionuclide therapy  

Science Conference Proceedings (OSTI)

Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F. [Radiology Division, City of Hope National Medical Center, Duarte, California 91010 (United States); Internal Medicine, University of California Davis Medical Center, 1508 Alhambra Boulevard, Suite 3100, Sacramento, California 95816 (United States); Department of Radiation Oncology, Wallace Tumor Institute WTI No. 117, University of Alabama at Birmingham, Birmingham, Alabama 35294 (United States)

2008-07-15T23:59:59.000Z

182

First SNS Target Replacement  

E-Print Network (OSTI)

· Replacement of the target module was accomplished using only remote handling tooling and procedures (hands operations. Remote Handling Control Room Manipulator Gallery #12;10 Managed by UT-Battelle for the U ­ Interim process fitting leak testing ­ Limitations on remote handling equipment reliability ­ Limitations

McDonald, Kirk

183

SNS Target Systems Operational  

E-Print Network (OSTI)

scheduling conflict with other remote handling work planned for the next shutdown. · The target and PBW integrated monolith and hot cell structures #12;32 Managed by UT-Battelle for the U.S. Department of Energy based on testing at Riken to 1.8 x 105 Gy · Improved neutronic performance and reduced remote handling

McDonald, Kirk

184

Many-core key-value store  

Science Conference Proceedings (OSTI)

Scaling data centers to handle task-parallel work-loads requires balancing the cost of hardware, operations, and power. Low-power, low-core-count servers reduce costs in one of these dimensions, but may require additional nodes to provide the required ... Keywords: 64-core Tilera TILEPro64, many-core key-value store, data centers, task-parallel workloads, low-core-count servers, low-power servers, under-utilizing memory, power consumption, high-core-count processor, clock rate, 4-core Intel Xeon L5520, 8-core AMD Opteron 6128 HE

M. Berezecki; E. Frachtenberg; M. Paleczny; K. Steele

2011-07-01T23:59:59.000Z

185

Quantum Key Distribution Highly Sensitive to Eavesdropping  

E-Print Network (OSTI)

We introduce a new quantum key distribution protocol that uses d-level quantum systems to encode an alphabet with c letters. It has the property that the error rate introduced by an intercept-and-resend attack tends to one as the numbers c and d increase. In dimension d=2, when the legitimate parties use a complete set of three mutually unbiased bases, the protocol achieves a quantum bit error rate of 57.1%. This represents a significant improvement over the 25% quantum bit error rate achieved in the BB84 protocol or 33% in the six-state protocol.

Brierley, Stephen

2009-01-01T23:59:59.000Z

186

Quantum Key Distribution Highly Sensitive to Eavesdropping  

E-Print Network (OSTI)

We introduce a new quantum key distribution protocol that uses d-level quantum systems to encode an alphabet with c letters. It has the property that the error rate introduced by an intercept-and-resend attack tends to one as the numbers c and d increase. In dimension d=2, when the legitimate parties use a complete set of three mutually unbiased bases, the protocol achieves a quantum bit error rate of 57.1%. This represents a significant improvement over the 25% quantum bit error rate achieved in the BB84 protocol or 33% in the six-state protocol.

Stephen Brierley

2009-10-14T23:59:59.000Z

187

Using targeted paraphrasing and monolingual crowdsourcing to improve translation  

Science Conference Proceedings (OSTI)

Targeted paraphrasing is a new approach to the problem of obtaining cost-effective, reasonable quality translation, which makes use of simple and inexpensive human computations by monolingual speakers in combination with machine translation. The key ... Keywords: Monolingual, crowdsourcing, human computation, machine translation, paraphrase, translation, translation interface, wisdom of crowds

Philip Resnik; Olivia Buzek; Yakov Kronrod; Chang Hu; Alexander J. Quinn; Benjamin B. Bederson

2013-06-01T23:59:59.000Z

188

Chemical biology drug discovery  

E-Print Network (OSTI)

Keywords Chemical biology drug discovery high-throughput screening protein ligands proteases novel chemical and biochemical methods for the identification and optimization of protein ligands us of pro- tein ligands. Results of this research are translated into protein-specific, chemical probes

Schüler, Axel

189

Analysis and design of a secure key exchange scheme  

Science Conference Proceedings (OSTI)

We propose a new key exchange scheme where the secret key is obtained by multiplying the powers of block upper triangular matrices. After studying the cryptographic properties of these block matrices, the theoretical aspects of this scheme are analyzed, ... Keywords: Block matrices, Cryptography, Discrete logarithm problem, Key exchange scheme, Public key, Quick exponentiation, Security, Triangular matrices

Rafael lvarez; Leandro Tortosa; Jos-Fco Vicent; Antonio Zamora

2009-05-01T23:59:59.000Z

190

Vehicle Technologies Office: Key Activities in Vehicles  

NLE Websites -- All DOE Office Websites (Extended Search)

Activities in Vehicles Activities in Vehicles We conduct work in four key areas to develop and deploy vehicle technologies that reduce the use of petroleum while maintaining or improving performance, power, and comfort. Research and development (R&D); testing and analysis; government and community stakeholder support; and education help people access and use efficient, clean vehicles that meet their transportation needs. Researcher loads a sample mount of battery cathode materials for X-ray diffraction, an analysis tool for obtaining information on the crystallographic structure and composition of materials. Research and Development of New Technologies Develop durable and affordable advanced batteries as well as other forms of energy storage. Improve the efficiency of combustion engines.

191

Toolpusher is key to efficient rig operation  

Science Conference Proceedings (OSTI)

Toolpushers earn a higher salary, control more personnel, and are responsible for a more expensive operation than many graduate MBAs. As a result, toolpushers are key to improved rig efficiencies and reduced crew turnover. For example, by having its toolpushers in Libya implement a new managerial approach, Santa Fe Drilling Co. reduced labor turnover 30%, reduced the number of lost-time accidents 58%, and increased average rig inspection scores 6%. During the boom years of drilling, toolpushers complained often about the poor quality of roustabouts and roughnecks assigned to them. Many toolpushers held poor screening of personnel responsible, and felt justified in firing those who were slow to adapt. Few of them considered that they were directly responsible. Today's toolpusher must realize that he is responsible not only for the rig, its maintenance, and its drilling performance, but for training and development of the rig's personnel as well.

Fortney, K.

1983-09-01T23:59:59.000Z

192

Key decisions near for Chad pipeline proposal  

Science Conference Proceedings (OSTI)

The World Bank is expected to play a key role in a proposed $3 billion development of oil fields in Chad and an export pipeline through Cameroon to the Atlantic Ocean. The project, which has been at least 4 years in the making, could see a breakthrough later this year. Esso Exploration and production Chad Inc. is operator for the consortium proposing the project. It holds a 40% interest, Ste. Shell Tchadienne de Recherches et d`Exploitation has 40%, and Elf Hydrocarbures Tchad has a 20% share it purchased from Chevron Corp. in 1993 (OGJ, February 1, 1993, p 25). The governments of Chad and Cameroon, which had approved a framework agreement for the pipeline in 1995, now are studying an assessment of the pipeline`s environmental impact. If they approve the plans, they are expected to apply to the World Bank for financing. The paper describes the Chad fields, the export pipeline, background information, and the Banks role.

Crow, P.

1997-05-12T23:59:59.000Z

193

Key Renewable Energy Opportunities for Oklahoma Tribes  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

TRIBAL LEADER FORUM SERIES TRIBAL LEADER FORUM SERIES KEY RENEWABLE ENERGY OPPORTUNITIES FOR OKLAHOMA TRIBES August 13, 2012 COX CONVENTION CENTER 100 West Sheridan Avenue, Oklahoma City, OK 73102 (405) 602-8500 The fifth in a series of planned U.S. DOE Office of Indian Energy-sponsored strategic energy development & investment forums, this forum is designed to give Oklahoma tribal leaders the opportunity to receive the latest updates on DOE's energy development efforts in Indian Country. The Forum will provide a venue for tribal leaders to discuss best practices in renewable energy development, including project development and finance, issues related to Oklahoma land ownership, and energy planning and energy markets. Tribal leaders will also have the opportunity to directly converse with each other by participating in a roundtable

194

Problems of Security Proofs and Fundamental Limit on Key Generation Rate in Quantum Key Distribution  

E-Print Network (OSTI)

It is pointed out that treatments of the error correcting code in current quantum key distribution protocols of the BB84 type are not correct under joint attack, and the general interpretation of the trace distance security criterion is also incorrect. With correct interpretation of the criterion as well as a correct treatment of the error correcting code and privacy amplification code, it is shown that even for an ideal system under just collective attack, the maximum tolerable quantum bit error rate is about 1.5% and a net key cannot actually be generated with practical error correcting codes even at such low rates, contrary to claims in the literature.

Horace P. Yuen

2012-05-16T23:59:59.000Z

195

Finite-key analysis of high-dimensional time-energy entanglement-based quantum key distribution  

E-Print Network (OSTI)

We present a security analysis against collective attacks for the recently proposed time-energy entanglement-based quantum key distribution protocol, given the practical constraints of single photon detector efficiency, channel loss, and finite-key considerations. We find a positive secure-key capacity when the key length increases beyond $10^4$ for eight-dimensional systems. The minimum key length required is reduced by the ability to post-select on coincident single-photon detection events. Including finite-key effects, we show the ability to establish a shared secret key over a 200 km fiber link.

Catherine Lee; Jacob Mower; Zheshen Zhang; Jeffrey H. Shapiro; Dirk Englund

2013-11-05T23:59:59.000Z

196

Learning to target: what works for behavioral targeting  

Science Conference Proceedings (OSTI)

Understanding what interests and delights users is critical to effective behavioral targeting, especially in information-poor contexts. As users interact with content and advertising, their passive behavior can reveal their interests towards advertising. ... Keywords: advertising, behavioral targeting, user modeling

Sandeep Pandey; Mohamed Aly; Abraham Bagherjeiran; Andrew Hatch; Peter Ciccolo; Adwait Ratnaparkhi; Martin Zinkevich

2011-10-01T23:59:59.000Z

197

Compression station key to Texas pipeline project  

SciTech Connect

This was probably the largest pipeline project in the US last year, and the largest in Texas in the last decade. The new compressor station is a key element in this project. TECO, its servicing dealer, and compression packager worked closely throughout the planning and installation stages of the project. To handle the amount of gas required, TECO selected the GEMINI F604-1 compressor, a four-throw, single-stage unit with a six-inch stroke manufactured by Weatherford Enterra Compression Co. (WECC) in Corpus Christi, TX. TECO also chose WECC to package the compressors. Responsibility for ongoing support of the units will be shared among TECO, the service dealer and the packager. TECO is sending people to be trained by WECC, and because the G3600 family of engines is still relatively new, both the Caterpillar dealer and WECC sent people for advanced training at Caterpillar facilities in Peoria, IL. As part of its service commitment to TECO, the servicing dealer drew up a detailed product support plan, encompassing these five concerns: Training, tooling; parts support; service support; and commissioning.

NONE

1996-10-01T23:59:59.000Z

198

Key parameters influencing the performance of photocatalytic oxidation  

NLE Websites -- All DOE Office Websites (Extended Search)

Key parameters influencing the performance of photocatalytic oxidation Key parameters influencing the performance of photocatalytic oxidation (PCO) air purification under realistic indoor conditions Title Key parameters influencing the performance of photocatalytic oxidation (PCO) air purification under realistic indoor conditions Publication Type Journal Article Year of Publication 2012 Authors Destaillats, Hugo, Mohamad Sleiman, Douglas P. Sullivan, Catherine Jacquiod, Jean Sablayrolles, and Laurent Molins Journal Applied Catalysis B: Environmental Volume 128 Pagination 159-170 Date Published 11/30/2012 Abstract Photocatalytic oxidation (PCO) air cleaning is a promising technology suitable for the elimination of a broad range of volatile organic compounds (VOCs). However, performance of poorly designed PCO systems may be affected by the formation of volatile aldehydes and other partially oxidized byproducts. This study explored the role of key design and dimensioning parameters that influence the effective removal of primary pollutants and can help reduce or eliminate the formation of secondary byproducts. A model pollutant mixture containing benzene, toluene, o-xylene, undecane, 1-butanol, formaldehyde and acetaldehyde was introduced at a constant rate in a 20-m3 environmental chamber operating at an air exchange rate of 1 h-1. Individual pollutant concentrations were kept at realistically low levels, between 2 and 40 μg m-3. A prototype air cleaner provided with flat or pleated PCO filtering media was operated in an external ductwork loop that recirculated chamber air at flow rates in the range 178-878 m3 h-1, corresponding to recycle ratios between 8.5 and 38. Air samples were collected upstream and downstream of the air cleaner and analyzed off-line to determine single-pass removal efficiency. The final-to-initial chamber concentration ratio was used to determine the global chamber removal efficiency for each pollutant. In the flat filter configuration, longer dwelling times of compounds on the TiO2 surface were attained by reducing the recirculation airflow by a factor of ∼5, leading to increasing total pollutant removal efficiency from 5% to 44%. Net acetaldehyde and formaldehyde removal was achieved, the later at airflow rates below 300 m3 h-1, illustrating the critical importance of controlling the contact time of primary and secondary pollutants with the TiO2 surface. The use of pleated media was shown to increase significantly the system performance by extending the dwelling time of pollutants on the irradiated surface of the PCO media, with a 70% degradation of target pollutants. With the pleated media, formaldehyde removal efficiency increased to 60%. Irradiation using either a UVC or a UVA lamp under identical flow conditions produced similar pollutant elimination. A simple correlation between the steady-state single pass removal efficiency and the global chamber removal efficiency was used to rationalize these experimental results and identify optimal operating conditions.

199

An Unusual Mechanism for the Antimicrobial Target Flavine-dependant  

NLE Websites -- All DOE Office Websites (Extended Search)

An Unusual Mechanism for the Antimicrobial An Unusual Mechanism for the Antimicrobial Target Flavine-dependant Thymidylate Synthase (FTDS) Classical thymidylate synthases, encoded by the thyA and TYMS genes, are present in most eukaryotes, including humans, and are frequently targeted by chemotherapeutic and antibiotic drugs. A recently discovered class of thymidylate synthases, the FDTSs encoded by the thyX gene has been found primarily in prokaryotes and viruses including several pathogens and biological warfare agents (see http://www.cdc.gov). Several organisms, including human pathogens, rely solely on thyX for thymidylate synthesis. FDTSs share no structure or sequence homology with classical thymidylate synthases (Fig 1), and thus present a promising new frontier for antibacterial/antiviral drug development.

200

Structure of the MTIP-MyoA Complex, a Key Component of the Malaria Parasite  

NLE Websites -- All DOE Office Websites (Extended Search)

the MTIP-MyoA Complex, a Key the MTIP-MyoA Complex, a Key Component of the Malaria Parasite Invasion Motor Malaria is one of the most devastating parasitic diseases worldwide, amounting to 300 to 500 million cases and ~2 million deaths per year (1). Multiple species of Plasmodium infect the human host, the most important ones being P. falciparum and P. vivax. Increased occurrence of multi-drug resistant Plasmodium strains reflects the need for new effective antimalarials. Human infection starts when Anopheline mosquitoes inject sporozoites into the skin during a blood meal. The sporozoites gain access to the blood stream and invade liver cells where they develop and multiply. Upon rupture of the infected liver cell, merozoites are released and rapidly enter red blood cells, where they undergo schizogony (cell multiplication) and propagate the blood cycle of the infection that causes the malaria symptoms (2).

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Beam heating of target foils  

SciTech Connect

A target rotator, built to reduce the effects of beam spot heating, is fully adjustable, holds three targets, is chamber independent, and takes up limited space. The expected temperature rise in the target is calculated from the Stefan--Boltzmann law. (PMA)

Corwin, W.C.

1975-01-01T23:59:59.000Z

202

Efficient password-based authenticated key exchange without public information  

Science Conference Proceedings (OSTI)

Since the first password-based authenticated key exchange (PAKE) was proposed, it has enjoyed a considerable amount of interest from the cryptographic research community. To our best knowledge, most of proposed PAKEs based on Diffie-Hellman key exchange ...

Jun Shao; Zhenfu Cao; Licheng Wang; Rongxing Lu

2007-09-01T23:59:59.000Z

203

Implementation of Distributed Key Generation Algorithms using Secure Sockets  

Science Conference Proceedings (OSTI)

Distributed Key Generation (DKG) protocols are indispensable in the design of any cryptosystem used in communication networks. DKG is needed to generate public/private keys for signatures or more generally for encrypting/decrypting messages. One such ...

A. T. Chronopoulos; F. Balbi; D. Veljkovic; N. Kolani

2004-08-01T23:59:59.000Z

204

Exploring the context : a small hotel in Key West  

E-Print Network (OSTI)

This thesis develops a personal method and approach for designing in a delicate context such as the Key West Historic District. This thesis is composed of two parts. The first part presents observations of Key West, focusing ...

VanBeuzekom, Edrick

1984-01-01T23:59:59.000Z

205

PDFs for nuclear targets  

E-Print Network (OSTI)

Understanding nuclear effects in parton distribution functions (PDF) is an essential component needed to determine the strange and anti-strange quark contributions in the proton. In addition Nuclear Parton Distribution Functions (NPDF) are critically important for any collider experiment with nuclei (e.g. RHIC, ALICE). Here two next-to-leading order chi^2-analyses of NPDF are presented. The first uses neutral current charged-lepton Deeply Inelastic Scattering (DIS) and Drell-Yan data for several nuclear targets and the second uses neutrino-nucleon DIS data. We compare the nuclear corrections factors (F_2^Fe/F_2^D) for the charged-lepton data with other results from the literature. In particular, we compare and contrast fits based upon the charged-lepton DIS data with those using neutrino-nucleon DIS data.

Karol Kovarik

2010-06-25T23:59:59.000Z

206

ORION laser target diagnostics  

SciTech Connect

The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

Bentley, C. D.; Edwards, R. D.; Andrew, J. E.; James, S. F.; Gardner, M. D.; Comley, A. J.; Vaughan, K.; Horsfield, C. J.; Rubery, M. S.; Rothman, S. D.; Daykin, S.; Masoero, S. J.; Palmer, J. B.; Meadowcroft, A. L.; Williams, B. M.; Gumbrell, E. T.; Fyrth, J. D.; Brown, C. R. D.; Hill, M. P.; Oades, K. [Plasma Physics Department, Atomic Weapons Establishment, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom); and others

2012-10-15T23:59:59.000Z

207

Updated distribution and reintroduction of the Lower Keys marsh rabbit  

E-Print Network (OSTI)

Listed as federally-endangered in 1990, the Lower Keys marsh rabbit (LKMR, Sylvilagus palustris hefneri) exists as a metapopulation in patches of wetland habitat in Florida?s Lower Keys. This study sought to address 2 priority actions identified by the LKMR Recovery Team: (1) monitoring of populations and (2) reintroduction. Monitoring the distribution and status of LKMR populations is critical for targeting future management actions. Informal transects for rabbit fecal pellets were used to survey habitat patches documented in1988?1995 surveys and to identify additional patches of occupied and potential habitat. Next, a buffer was created around patches to help managers account for uncertainty in rabbit movements and to identify groups of patches that might function as local populations. Surveys included 228 patches of occupied and potential habitat, 102 of which were occupied by rabbits. Patches were arranged in 56 occupied and 88 potential populations. Surveys revealed new patches of both occupied and potential habitat. Considering only areas included in 1988?1995 surveys, however, revealed a net decrease in the number of occupied patches. Many of the recently extirpated populations, which tended to occupy the periphery of larger islands or small neighboring islands, were unlikely to be recolonized without human intervention. Reintroduction provides a means of artificially recolonizing potential habitat. Two pilot reintroductions were conducted to evaluate this conservation strategy for the species. The second reintroduction was postponed, but the first effort met all criteria for short-term success, including survival comparable to a control group, fidelity to release sites, and evidence of reproduction. There are a limited number of potential source populations for translocations. Future efforts should consider using in-situ captive breeding to prevent potential long-term impacts to these populations. Few potential release sites exhibited suitable habitat quality and landscape context. Thus, for reintroduction to be more widely-applied for this species, it must be part of a comprehensive management plan involving land acquisition, control of secondary impacts from development, and habitat restoration and enhancement.

Faulhaber, Craig Alan

2003-12-01T23:59:59.000Z

208

Key Ingredient: Change in Material Boosts Prospects of ...  

Science Conference Proceedings (OSTI)

Key Ingredient: Change in Material Boosts Prospects of Ultrafast Single-photon Detector. From NIST Tech Beat: June 30, 2011. ...

2011-10-14T23:59:59.000Z

209

Nano Changes Rise to Macro Importance in a Key Electronics ...  

Science Conference Proceedings (OSTI)

Nano Changes Rise to Macro Importance in a Key Electronics Material. From NIST Tech Beat: April 7, 2009. ...

2012-10-01T23:59:59.000Z

210

Better 'Photon Loops' May Be Key to Computer and Physics ...  

Science Conference Proceedings (OSTI)

Better 'Photon Loops' May Be Key to Computer and Physics Advances. From NIST Tech Beat: August 22, 2011. ...

2012-08-23T23:59:59.000Z

211

Energy Usage Data Standard for US Smart Grid Passes Key ...  

Science Conference Proceedings (OSTI)

Energy Usage Data Standard for US Smart Grid Passes Key Advisory Panel Vote. From NIST Tech Beat: March 1, 2011. ...

2011-03-01T23:59:59.000Z

212

ITL Bulletin - ITL Updates Glossary of Key Information Security ...  

Science Conference Proceedings (OSTI)

... ITL UPDATES GLOSSARY OF KEY INFORMATION SECURITY TERMS ... ITL plans to keep the glossary current by providing updates online. ...

2013-06-12T23:59:59.000Z

213

Quantum key distribution system clocked at 2 GHz  

E-Print Network (OSTI)

Quantum key distribution system clocked at 2 GHz Karen J. Gordon, Veronica Fernandez, Gerald S, Ireland http://www.phy.hw.ac.uk/resrev/photoncounting/index.html Abstract: An improved quantum key-based quantum key distribution test system performance in terms of transmission distance and quantum bit error

Buller, Gerald S.

214

Targeting Political Advertising on Television ?  

E-Print Network (OSTI)

We study the targeting of political advertising by congressional candidates on television. Targeting strategies for television differ from targeting strategies for direct mail advertising or get out the vote efforts because candidates cannot target voters individually. Instead, candidates must target television programs with viewers most similar to the desired target voters. Thus, for targeted advertising to have value, the audiences for television programs must differ in meaningful ways and advertising must be effective. In this project, we develop and estimate a model of targeted advertising for U.S. congressional races. We study whether television shows segment potential voters sufficiently to allow for effective targeting and we consider the effect of television advertising- whether it persuades individuals to vote for a particular candidate or mobilizes them to vote in general. Our results suggest the function of television advertising is primarily to persuade. Moreover, we find that there is sufficient variation in the distribution of viewer characteristics across television programs to allow for effective targeting. The most effective targeting strategies therefore involve both parties adopting similar strategies of advertising primarily on programs with audiences containing many swing voters that are likely to vote. While

Mitchell Lovett; Michael Peress

2010-01-01T23:59:59.000Z

215

Target Diagnostics Supports NIF's Path to Ignition  

SciTech Connect

The physics requirements derived from the National Ignition Facility (NIF) experimental campaigns are leading to a wide variety of target diagnostics. Software development for the control and analysis of these diagnostics is included in the NIF Integrated Computer Control System, Diagnostic Control System and Data Visualization. These projects implement the configuration, controls, data analysis and visual representation of most of these diagnostics. To date, over 40 target diagnostics have been developed to support NIF experiments. In 2011 diagnostics were developed or enhanced to measure Ignition performance in a high neutron yield environment. Performance is optimized around four key variables: Adiabat (a) which is the strength and timing of four shocks delivered to the target, Velocity (V) of the imploding target, Mix (M) is the uniformity of the burn, and the Shape (S) of the imploding Deuterium Tritium (DT) hot spot. The diagnostics used to measure each of these parameters is shown in figure 1. Adiabat is measured using the Velocity Interferometer System for Any Reflector (VISAR) diagnostic consisting of three streak cameras. To provide for more accurate adiabat measurements the VISAR streak cameras were enhanced in FY11 with a ten comb fiducial signal controller to allow for post shot correction of the streak camera sweep non-linearity. Mix is measured by the Neutron Time of Flight (NTOF) and Radiochemical Analysis of Gaseous Samples (RAGS) diagnostics. To accommodate high neutron yield shots, NTOF diagnostic controls are being modified to use Mach Zehnder interferometer signals to allow the digitizers to be moved from near the target chamber to the neutron shielded diagnostic mezzanine. In December 2011 the first phase of RAGS diagnostic commissioning will be completed. This diagnostic will analyze the tracers that are added to NIF target capsules that undergo nuclear reactions during the shot. These gases are collected and purified for nuclear counting by the RAGS system. Three new instrument controllers were developed and commissioned to support this diagnostic. A residual-gas analyzer (RGA) instrument measures the gas content at various points in the system. The Digital Gamma Spectrometer instrument measures the radiological spectrum of the decaying gas isotopes. A final instrument controller was developed to interface to a PLC based Gas collection system. In order to support the implosion velocity measurements an additional Gated X-ray Detector (GXD) diagnostic was tested and commissioned. This third GXD views the target through a slit contained in its snout and allows the other GXD diagnostics to be used for measuring the shape on the same shot. In order to measure the implosion shape in a high neutron environment, Actide Readout In A Neutron Environment (ARIANE) and Neutron Imaging (NI) diagnostics were commissioned. The controls for ARIANE, a fixed port gated x-ray imager, contain a neutron shielded camera and micro channel plate pulser with its neutron sensitive electronics located in the diagnostic mezzanine. The NI diagnostic is composed of two Spectral Instruments SI-1000 cameras located 20M from the target and provides neutron images of the DT hot spot for high yield shots. The development and commissioning of these new or enhanced diagnostics in FY11 have provided meaningful insight that facilitates the optimization of the four key Ignition variables. In FY12 they will be adding three new diagnostics and enhancing four existing diagnostics in support of the continuing optimization series of campaigns.

Shelton, R

2011-12-07T23:59:59.000Z

216

Electro- and photonuclear physics with polarized beams and targets  

DOE Green Energy (OSTI)

Two long-standing issues in photonuclear physics, the giant M1 resonance in Pb and deuteron photodisintegration, have been studied recently with polarized photons at Urbana and Frascati, respectively. The implications that this work has for settling these key issues will be discussed. In addition, the advantages of the internal polarized target method for electron scattering studies will be discussed and the technology of internal polarized target development will be reviewed. The first results from a spin-exchange, optically-pumped polarized H and D source will be presented.

Holt, R.J.

1987-01-01T23:59:59.000Z

217

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts November 29, 2011 - 4:34pm Addthis THE WHITE HOUSE Office of the Press Secretary FOR IMMEDIATE RELEASENovember 29, 2011 President Obama Announces More Key Administration Posts WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Frederick "Rick" Barton - Assistant Secretary for Conflict and Stabilization Operations and Coordinator for Reconstruction and Stabilization, Department of State Arun Majumdar - Under Secretary of Energy, Department of Energy Marie F. Smith - Member, Social Security Advisory Board The President also announced his intent to appoint the following

218

Secret key distillation from shielded two-qubit states  

Science Conference Proceedings (OSTI)

The quantum states corresponding to a secret key are characterized using the so-called private states, where the key part consisting of a secret key is shielded by the additional systems. Based on the construction, it was shown that a secret key can be distilled from bound entangled states. In this work, I consider the shielded two-qubit states in a key-distillation scenario and derive the conditions under which a secret key can be distilled using the recurrence protocol or the two-way classical distillation, advantage distillation together with one-way postprocessing. From the security conditions, it is shown that a secret key can be distilled from bound entangled states in a much wider range. In addition, I consider the case that in which white noise is added to quantum states and show that the classical distillation protocol still works despite a certain amount of noise although the recurrence protocol does not.

Bae, Joonwoo [School of Computational Sciences, Korea Institute for Advanced Study, Seoul 130-722 (Korea, Republic of)

2010-05-15T23:59:59.000Z

219

Secret key distillation from shielded two-qubit states  

E-Print Network (OSTI)

The quantum states corresponding to a secret key are characterized using the so-called private states, where the key part consisting of a secret key is shielded by the additional systems. Based on the construction, it was shown that a secret key can be distilled from bound entangled states. In this work, I consider the shielded two-qubit states in a key-distillation scenario and derive the conditions under which a secret key can be distilled using the recurrence protocol or the two-way classical distillation, advantage distillation together with one-way postprocessing. From the security conditions, it is shown that a secret key can be distilled from bound entangled states in a much wider range. In addition, I consider the case that in which white noise is added to quantum states and show that the classical distillation protocol still works despite a certain amount of noise although the recurrence protocol does not.

Joonwoo Bae

2008-03-03T23:59:59.000Z

220

Mexico Border HIV Drug abuse  

E-Print Network (OSTI)

The Author(s) 2011. This article is published with open access at Springerlink.com Abstract We examined correlates of ever injecting drugs in Mexico among residents of San Diego, California. From 2007 to 2010, injecting drug users (IDUs) in San Diego underwent an interviewer-administered survey. Logistic regression identified correlates of injection drug use in Mexico. Of 302 IDUs, 38 % were Hispanic, 72 % male and median age was 37; 27 % ever injected in Mexico; 43% reported distributive syringe sharing there. Factors independently associated with ever injecting drugs in Mexico included being younger at first injection, injecting heroin, distributive syringe sharing at least half of the time, and transporting drugs over the last 6 months. One-quarter of IDUs reported ever injecting drugs in Mexico, among whom syringe sharing was common, suggesting possible mixing between IDUs in the Mexico-US border region. Prospective studies should monitor trends in cross-border drug use in light of recent Mexican drug policy reforms partially decriminalizing drug possession.

Tyson Volkmann; Sanghyuk S. Shin; Richard S. Garfein; Irina Artamanova; Steffanie A. Strathdee; T. Volkmann; S. S. Shin; R. S. Garfein; R. A. Pollini; K. D. Wagner; I. Artamanova; S. A. Strathdee; T. L. Patterson

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

In silico approach to discover multi-target-directed ligands for the treatment of Alzheimer's disease  

Science Conference Proceedings (OSTI)

Multi-target directed (MTD) drugs have been found to be very effective in controlling neurodegenerative diseases. We have developed an in silico strategy to screen molecules for both AChE and BACE-1 enzyme dual inhibition. Pharmacophore model ... Keywords: ?-secretase, in silico drug design, ADMET screening, GOLD, GOLD score, HIPHOP, Lipinski's rule, acetylcholinesterase, blood-brain barrier, cholinesterase inhibitors, discovery studio, docking, pharmacophore modeling, protein data bank, virtual screening

Ankit Tyagi; Shikhar Gupta; C. Gopi Mohan

2010-02-01T23:59:59.000Z

222

Drug Detection Study  

Office of Scientific and Technical Information (OSTI)

ORISE-07-NSEM-0544 ORISE-07-NSEM-0544 U.S. Department of Energy Office of Health, Safety and Security Office of Security Policy Drug Retention Times Center for Human Reliability Studies Oak Ridge Institute for Science and Education Operated by Oak Ridge Associated Universities For the U.S. Department of Energy Oak Ridge Associated Universities (ORAU) is a university consortium leveraging the scientific strength of major research institutions to advance science and education by partnering with national laboratories, government agencies, and private industry. ORAU manages the Oak Ridge Institute for Science and Education for the U.S. Department of Energy. The Oak Ridge Institute for Science and Education (ORISE) is a U.S. Department of Energy institute focusing on

223

Multiple target laser ablation system  

DOE Patents (OSTI)

A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

Mashburn, Douglas N. (Knoxville, TN)

1996-01-01T23:59:59.000Z

224

Inertial-confinement-fusion targets  

DOE Green Energy (OSTI)

Inertial confinement fusion (ICF) targets are made as simple flat discs, as hollow shells or as complicated multilayer structures. Many techniques have been devised for producing the targets. Glass and metal shells are made by using drop and bubble techniques. Solid hydrogen shells are also produced by adapting old methods to the solution of modern problems. Some of these techniques, problems and solutions are discussed. In addition, the applications of many of the techniques to fabrication of ICF targets is presented.

Hendricks, C.D.

1981-11-16T23:59:59.000Z

225

EIA Data: 2011 United States Residential Sector Key Indicators and  

Open Energy Info (EERE)

Residential Sector Key Indicators and Residential Sector Key Indicators and Consumption Dataset Summary Description This dataset is the 2011 United States Residential Sector Key Indicators and Consumption, part of the Annual Energy Outlook that highlights changes in the AEO Reference case projections for key energy topics. Source EIA Date Released December 16th, 2010 (4 years ago) Date Updated Unknown Keywords consumption EIA energy residential sector key indicators Data application/vnd.ms-excel icon Residential Sector Key Indicators and Consumption (xls, 62.5 KiB) Quality Metrics Level of Review Peer Reviewed Comment Temporal and Spatial Coverage Frequency Annually Time Period License License Open Data Commons Public Domain Dedication and Licence (PDDL) Comment http://www.eia.gov/abouteia/copyrights_reuse.cfm

226

Security proof of practical quantum key distribution schemes  

E-Print Network (OSTI)

This paper provides a security proof of the Bennett-Brassard (BB84) quantum key distribution protocol in practical implementation. To prove the security, it is not assumed that defects in the devices are absorbed into an adversary's attack. In fact, the only assumption in the proof is that the source is characterized. The proof is performed by lower-bounding adversary's Renyi entropy about the key before privacy amplification. The bound reveals the leading factors reducing the key generation rate.

Yodai Watanabe

2005-06-29T23:59:59.000Z

227

Realizing Technologies for Magnetized Target Fusion  

SciTech Connect

Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

Wurden, Glen A. [Los Alamos National Laboratory

2012-08-24T23:59:59.000Z

228

Microfabricated injectable drug delivery system  

DOE Patents (OSTI)

A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

2002-01-01T23:59:59.000Z

229

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts May 28, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Gordon Heddell, Inspector General, Department of Defense; Ellen Murray, Assistant Secretary for Resources and Technology, Department of Health and Human Services; Polly Trottenberg, Assistant Secretary for Transportation Policy, Department of Transportation; and James J. Markowsky, Assistant Secretary for Fossil Energy, Department of Energy. President Obama said, "Each of these individuals brings extensive expertise in their chosen fields, and they are joining my administration at a time

230

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts April 17, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Christine M. Griffin, Deputy Director of Office of Personnel Management; Kevin Concannon, Under Secretary for Food, Nutrition and Consumer Services, United States Department of Agriculture; Rajiv Shah, Under Secretary for Research, Education, and Economics, United States Department of Agriculture; Michael Nacht, Assistant Secretary of Defense (Global Strategic Affairs), Department of Defense; Mercedes Márquez, Assistant Secretary for Community Planning and Development, Department of Housing and

231

Florida Keys Electric Cooperative - Residential Rebate Program | Department  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Florida Keys Electric Cooperative - Residential Rebate Program Florida Keys Electric Cooperative - Residential Rebate Program Florida Keys Electric Cooperative - Residential Rebate Program < Back Eligibility Residential Savings Category Home Weatherization Commercial Weatherization Sealing Your Home Heating & Cooling Commercial Heating & Cooling Cooling Insulation Design & Remodeling Windows, Doors, & Skylights Program Info State Florida Program Type Utility Rebate Program Rebate Amount Rebates $25 - $500, max $1000 per member Florida Keys Electric Cooperative offers residential members rebates for installing energy efficient measures. To qualify for rebates, members must first call FKEC and make an appointment for a free home energy audit. An FKEC trained auditor will assess the home and make recommendations for

232

Natural Gas Markets: Recent Changes and Key Drivers  

U.S. Energy Information Administration (EIA)

U.S. Energy Information Administration Independent Statistics & Analysis www.eia.gov Natural Gas Markets: Recent Changes and Key Drivers for

233

NREL: News - NREL Fills Key Leadership Role for Energy Systems...  

NLE Websites -- All DOE Office Websites (Extended Search)

513 NREL Fills Key Leadership Role for Energy Systems Integration June 17, 2013 Bryan J. Hannegan will join the Energy Department's National Renewable Energy Laboratory on June 24...

234

Advanced Analysis Software Key to New, Energy-Efficient ...  

Advanced Analysis Software Key to New, Energy-Efficient Technologies Leveraging Scientific and Engineering Know-How to Advance Sources of Renewable En ...

235

EIA highlights key factors in new energy and financial markets ...  

U.S. Energy Information Administration (EIA)

Yesterday, EIA launched a new web-based assessment highlighting key factors that can affect crude oil prices called "Energy and Financial Markets: What Drives Crude ...

236

Report Identifies Three Key R&D Priorities for Future ...  

Science Conference Proceedings (OSTI)

... Networking and Information Technology Research and Development Program. For more details, see Report Identifies Three Key R&D Priorities for ...

2011-07-18T23:59:59.000Z

237

Thailand-Key Results and Policy Recommendations for Future Bioenergy...  

Open Energy Info (EERE)

013 Country Thailand UN Region South-Eastern Asia References Thailand-Key Results and Policy Recommendations for Future Bioenergy Development1 Abstract "The Government of...

238

TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Radiation Monitoring Subgroup TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring Subgroup Radiation Monitoring Subgroup Draft Work Plan - February 4, 2008 More...

239

Knowledge, Skills, and Abilities for Key Radiation Protection...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Notice No. 1 November 2007 DOE STANDARD KNOWLEDGE, SKILLS, AND ABILITIES FOR KEY RADIATION PROTECTION POSITIONS AT DOE FACILITIES U.S. Department of Energy FSC 6910...

240

Key Facts about the Mathematics and Computer Science Division...  

NLE Websites -- All DOE Office Websites (Extended Search)

Publications Documents Key Facts about the Mathematics and Computer Science Division Researchers in the Mathematics and Computer Science Division attack complex problems in four...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Advanced Analysis Software Key to New, Energy-Efficient ...  

Advanced Analysis Software Key to New, Energy-Efficient Technologies Leveraging Scientific and Engineering Know-How to Advance Sources of Renewable Energy

242

Fossil Energy Announces Addition of Three Key Staff Members ...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

appointment of three key senior staff members to the Office of Fossil Energy - James F. Wood, Deputy Assistant Secretary for Clean Coal; Christopher A. Smith, Deputy Assistant...

243

DVD Production Process & Key Factors for Quality Discs  

Science Conference Proceedings (OSTI)

... wide market share for DVD +/- RW; #2 World-wide market share for CD ... Key factor - deep knowledge of forming thin metal film - optimization of ...

2006-01-20T23:59:59.000Z

244

TEC Working Group Topic Groups Rail Key Documents Intermodal...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Intermodal Subgroup TEC Working Group Topic Groups Rail Key Documents Intermodal Subgroup Intermodal Subgroup Draft Work Plan More Documents & Publications TEC Working Group Topic...

245

Big Coppitt Key, Florida: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

Bureau 2005 Place to 2006 CBSA Retrieved from "http:en.openei.orgwindex.php?titleBigCoppittKey,Florida&oldid227749" Categories: Places Stubs Cities What links here...

246

Big Pine Key, Florida: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

Bureau 2005 Place to 2006 CBSA Retrieved from "http:en.openei.orgwindex.php?titleBigPineKey,Florida&oldid227765" Categories: Places Stubs Cities What links here...

247

Building Technologies Office: Key Activities in Energy Efficiency  

NLE Websites -- All DOE Office Websites (Extended Search)

work in three key areas in order to continually develop innovative, cost-effective energy saving solutions. research and development (R&D), market stimulation, and building...

248

Proposed generation and compression of a target plasma for MTF  

SciTech Connect

Magnetized target fusion (MTF), in which a magnetothermally insulated plasma is hydrodynamically compressed to fusion conditions, represents an approach to controlled fusion which avoids difficulties of both traditional inertial confinement and magnetic confinement approaches. The authors are proposing to demonstrate the feasibility of magnetized target fusion by: (1) creating a suitable magnetized target plasma, (2) performing preliminary liner compression experiments using existing pulsed power facilities and demonstrated liner performance. Once the target plasma and the means for its generation have been optimized, the authors plan to conduct preliminary liner compression experiments aimed at demonstrating the near-adiabatic compression of the target plasma desired for MTF. Relevant liner compression experiments have been performed at Los Alamos in the Scyllac Fast Liner Program and, more recently, in the Pegasus facility and the Procyon explosive pulsed power program. In a series of liner experiments they plan to map out the dependence of temperature and neutron production as functions of the initial plasma conditions and the liner compression achieved. With the above research program, they intend to demonstrate most of the key principles involved in magnetized target fusion, and develop the experimental and theoretical tools needed to design and execute fully integrated MTF ignition experiments.

Kirkpatrick, R.C.; Thurston, R.S.; Chrien, R.E. [and others

1995-09-01T23:59:59.000Z

249

A Target-Oriented Magnetotelluric Inversion Approach For Characterizing The  

Open Energy Info (EERE)

Target-Oriented Magnetotelluric Inversion Approach For Characterizing The Target-Oriented Magnetotelluric Inversion Approach For Characterizing The Low Enthalpy Gross Schonebeck Geothermal Reservoir Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Journal Article: A Target-Oriented Magnetotelluric Inversion Approach For Characterizing The Low Enthalpy Gross Schonebeck Geothermal Reservoir Details Activities (0) Areas (0) Regions (0) Abstract: Electrical conductivity is a key parameter for the exploration and characterization of geothermal reservoirs as hot mineralized formation water of active geothermal areas usually exhibits significantly higher conductivity than the surrounding host rock. Here we present results of a magnetotelluric (MT) exploration experiment carried out in the vicinity of the Gross Schonebeck geothermal test site in Northern Germany, where a

250

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

of banks and private capital in energy efficiencybanks that tend to be conservative in investments, and who are not used to the idea of energyEnergy Consumption Protocol, 154 the U.S. Initiative on Joint Implementation, the World Bank

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

251

Developing a Commercial Production Process for 500,000 Targets Per Day - a Key Challenge for Inertial Fusion Energy  

E-Print Network (OSTI)

Bull. Am. Phys. Soc. 50, 308 (2005)47th American Physical Society Annual Meeting of Division of Plasma Physics Denver Colorado, US, 2005999612090

Goodin, D.T.

2005-08-25T23:59:59.000Z

252

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

Summer Study on Energy Efficiency in Industry. Washington,related to industrial energy efficiency or GHG emissionsDenmark - Energy Efficiency Agreements. ... 4

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

253

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

and a Facility Energy Assessment Matrix to help energyalso developed an Energy Program Assessment Matrix to help

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

254

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

locID=628&docID=-1 Sustainable Energy Ireland, 2006. Energyguideline.pdf Sustainable Energy Ireland, 2006.Sustainable Energy Irelands Energy Agreements Programme.

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

255

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

the costs associated with energy efficiency investments.B. , 2003. Energy Efficiency Improvement and Cost SavingM. , 2003. Energy Efficiency Improvement and Cost Saving

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

256

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

less than six years. The energy audits were carried out bythe following: 86 1. Energy audit and analysis. The companycertification body. (More on energy audits is contained in

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

257

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

Chinese cement and iron/steel industry is underway. http://data required for the steel industry included total primaryrepresentatives of the steel industry, the government, and

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

258

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

STAR for Industry Energy Guides 52 include both process-s sector- wide energy efficiency guides provide informationfor Cement Making: An ENERGY STAR Guide for Energy and Plant

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

259

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

Ireland, 2006. Energy Management Systems. I.S. 393:20052004. The Energy Management System Specification withA corporate energy management system can be expanded to

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

260

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

and reduce electricity consumption by 1 TWh/year, saving theyear in 2006, 117 companies representing about one fifth of Swedens total electricity consumption

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network (OSTI)

of Subsidizing Energy Saving Technologies: Evidence fromfor Investments in Energy-saving Equipment and SustainableCapital Allowances for Energy-Saving Investments. http://

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

262

Robust data sharing with key-value stores  

Science Conference Proceedings (OSTI)

A key-value store (KVS) offers functions for storing and retrieving values associated with unique keys. KVSs have become widely used as shared storage solutions for Internet-scale distributed applications. We present a fault-tolerant wait-free efficient ... Keywords: cloud storage, distributed storage

Cristina Basescu; Christian Cachin; Ittay Eyal; Robert Haas; Marko Vukolic

2011-06-01T23:59:59.000Z

263

Robust data sharing with key-value stores  

Science Conference Proceedings (OSTI)

A key-value store (KVS) offers functions for storing and retrieving values associated with unique keys. KVSs have become the most popular way to access Internet-scale cloud storage systems. We present an efficient wait-free algorithm that ...

Cristina Basescu; Christian Cachin; Ittay Eyal; Robert Haas; Alessandro Sorniotti; Marko Vukolic; Ido Zachevsky

2012-06-01T23:59:59.000Z

264

A framework for password-based authenticated key exchange1  

Science Conference Proceedings (OSTI)

In this paper, we present a general framework for password-based authenticated key exchange protocols, in the common reference string model. Our protocol is actually an abstraction of the key exchange protocol of Katz et al. and is based on the recently ... Keywords: Passwords, authentication, dictionary attack, projective hash functions

Rosario Gennaro; Yehuda Lindell

2006-05-01T23:59:59.000Z

265

Efficient decoy-state quantum key distribution with quantified security  

E-Print Network (OSTI)

We analyse the finite-size security of the efficient Bennett-Brassard 1984 protocol implemented with decoy states and apply the results to a gigahertz-clocked quantum key distribution system. Despite the enhanced security level, the obtained secure key rates are the highest reported so far at all fibre distances.

M. Lucamarini; K. A. Patel; J. F. Dynes; B. Frhlich; A. W. Sharpe; A. R. Dixon; Z. L. Yuan; R. V. Penty; A. J. Shields

2013-10-01T23:59:59.000Z

266

An extension of secure group communication using key graph  

Science Conference Proceedings (OSTI)

With the continuously emerging of Internet applications based on secure group communication, the design of secure group communication becomes an important Internet design topic. Group key management is important for secure group communication. Previous ... Keywords: Batch rekey, Group security, Key graph, Rekey

Zhang Jun; Zhou Yu; Ma Fanyuan; Gu Dawu; Bai Yingcai

2006-10-01T23:59:59.000Z

267

Electricity and Development: Global Trends and Key Challenges  

E-Print Network (OSTI)

Electricity and Development: Global Trends and Key Challenges Romeo Pacudan, PhD Risoe National · Prospects for electricity development · Investment requirements · Key challenges · Final remarks #12 and the transport burden in Tanzania. Source: Modi, 2004 #12;2. Energy and Human Development Access to electricity

268

Cryptanalysis of two three-party encrypted key exchange protocols  

Science Conference Proceedings (OSTI)

Due to the simplicity of maintaining human memorable passwords without any assistant storage device, password-based three-party encrypted key exchange (3PEKE) protocol has become one of the most promising research fields on user authentication and secure ... Keywords: Authentication, Cryptanalysis, Security, Three-party encrypted key exchange (3PEKE) protocol, Undetectable on-line password guessing attacks

N. W. Lo; Kuo-Hui Yeh

2009-11-01T23:59:59.000Z

269

Energy Security: A Key Requirement forSustainable Development  

E-Print Network (OSTI)

1 Energy Security: A Key Requirement forSustainable Development Perspective and Action Plan Robert Card Under Secretary US Department of Energy August 30, 2002 Session One: Maintaining Energy Security WSSD Side Event Energy for Sustainable Development IEA/UNEP/Eskom #12;2 Energy Security is a Key

270

MeerKAT Key Project Science, Specifications, and Proposals  

E-Print Network (OSTI)

We present the specifications of the MeerKAT Karoo Array Telescope, the South African Square Kilometre Array Precursor. Some of the key science for MeerKAT is described in this document. We invite the community to submit proposals for Large Key Projects.

Booth, R S; Jonas, J L; Fanaroff, B

2009-01-01T23:59:59.000Z

271

A matricial public key cryptosystem with digital signature  

Science Conference Proceedings (OSTI)

We describe a new public key cryptosystem using block upper triangular matrices with elements in Zp, based on a generalization of the discrete logarithm problem over a finite group. The proposed cryptosystem is very efficient, requiring ... Keywords: DLP, Diffie-Hellman, ElGamal, cryptography, digital signature, finite fields, polynomial matrices, public-key, security

Rafael Alvarez; Francisco-Miguel Martinez; Jose-Francisco Vicent; Antonio Zamora

2008-04-01T23:59:59.000Z

272

Using a shallow linguistic kernel for drug-drug interaction extraction  

Science Conference Proceedings (OSTI)

A drug-drug interaction (DDI) occurs when one drug influences the level or activity of another drug. Information Extraction (IE) techniques can provide health care professionals with an interesting way to reduce time spent reviewing the literature for ... Keywords: Biomedical information extraction, Drug-drug interactions, Machine learning, MetaMap, Patient safety, Shallow linguistic kernel, Unified medical language system

Isabel Segura-Bedmar; Paloma MartNez; Cesar De Pablo-SNchez

2011-10-01T23:59:59.000Z

273

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

More Key Administration Posts More Key Administration Posts President Obama Announces More Key Administration Posts July 8, 2011 - 12:00am Addthis THE WHITE HOUSE Office of the Press Secretary WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Michael A. Hammer, Assistant Secretary for Public Affairs, Department of State Charles McConnell, Assistant Secretary for Fossil Energy, Department of Energy The President also announced his intent to appoint the following individuals to key Administration posts: Terry Guen, Member, Advisory Council on Historic Preservation Dorothy T. Lippert, Member, Advisory Council on Historic Preservation Rosemary A. Joyce, Member, Cultural Property Advisory Committee President Obama said, "Our nation will be greatly served by the talent and

274

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Key Dates Key Dates Albert Einstein Distinguished Educator Fellowship (AEF) Program Einstein Fellowship Home Eligibility Benefits Obligations How to Apply Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A RSS Feeds FeedbackShare Page Key Dates for the 2014-2015 Einstein Fellowship Application process. On-line Application Opens September 24, 2013 Application Deadline 5:00pm EST December 4, 2013 Application Review 7-8 weeks Notification to Semi-Finalists [Travel Arrangements made for Interviews in Washington, DC] Late January 2014 Interviews in Washington, DC February 23-25, 2014 Finalists Notifications March 2014 Congressional Fellows Placement Interviews June - July 2014 Fellows Arrive in Washington, DC August 2014 Orientation meeting for the 2014-2015 Einstein Fellows

275

Security Notions for Quantum Public-Key Cryptography  

E-Print Network (OSTI)

It is well known that Shor's quantum algorithm for integer factorization can break down the RSA public-key cryptosystem, which is widely used in many cryptographic applications. Thus, public-key cryptosystems in the quantum computational setting are longed for cryptology. In order to define the security notions of public-key cryptosystems, we have to model the power of the sender, receiver, adversary and channel. While we may consider a setting where quantum computers are available only to adversaries, we generally discuss what are the right security notions for (quantum) public-key cryptosystems in the quantum computational setting. Moreover, we consider the security of quantum public-key cryptosystems known so far.

Takeshi Koshiba

2007-02-19T23:59:59.000Z

276

Key ACA Terms A quick reference of frequently used terms  

E-Print Network (OSTI)

a comprehensive package of items and services, known as essential health benefits. Essential health benefits must services, including behavioral health treatment; prescription drugs; rehabilitative and habilita- tive services and devices; laboratory services; preventive and wellness services and chronic disease management

Acton, Scott

277

Whole-building energy targets ``A`` prototype, initial version  

SciTech Connect

The Whole-Building Energy Targets project, sponsored by the US Department of Energy (DOE), is developing a methodology for generating energy performance targets for commercial buildings. The methodology and implementing software have potential applications to energy standards and guidelines, advanced building design tools, energy retrofit analysis, demand-side management programs, and the planning and assessment of building energy research. Pacific Northwest Laboratory (PNL) is conducting the Targets project with assistance from three leading building-industry associations -- the American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc. (ASHRAE); the Illuminating Engineering Society of North America (IES); and the American Institute of Architects/Association of Collegiate Schools of Architecture (AIA/ACSA) Council on Architectural Research. The project`s objective is to develop a methodology to generate energy performance targets for design, check the compliance of commercial-building designs with those targets, and evaluate design alternatives. Two previous phases of the project have been completed -- Phase 1 Planning and Phase 2 Concept Development. The current phase is called Phase 3 System Development. Key elements of the technical approach are that targets will be based on space functions (i.e., the collection of activities and corresponding areas within a building) rather than building types, generated using economic optimization methods, and custom-generated for specific building projects. Pacific Northwest Laboratory is developing computer software, referred to as the ``Targets software,`` that implements this methodology. The Targets software will enable the methodology to be demonstrated and tested and is intended to provide the basis for final computer applications incorporating the methodology.

Briggs, R.S.

1994-09-01T23:59:59.000Z

278

Countdown to Fixed Target INSIDE  

NLE Websites -- All DOE Office Websites (Extended Search)

17, 1996 17, 1996 Number 10 Countdown to Fixed Target INSIDE 2 University Close-Up: The University of Illinois 4 Tollestrup Elected to National Academy 5 Bardeen Receives Sakurai Prize 6 Take Your Daughters and Sons to Work Day "At this moment," Fermilab Director John Peoples told the House Subcommittee on Energy and Environment in testimony deliv- ered in Washington on May 8, "Fermilab is in the midst of the transition from collider opera- tions to fixed-target operations. In June, we will begin extracting a beam of protons from the Tevatron, the highest-energy external beam in the world. By directing this beam onto eight targets we will create eight distinct particle beams that will in turn support 10 unique experiments. Although fixed-target experi- ments cannot explore the high-energy frontier

279

Multiple agents moving target search  

Science Conference Proceedings (OSTI)

Traditional single-agent search algorithms usually make simplifying assumptions (single search agent, stationary target, complete knowledge of the state, and sufficient time). There are algorithms for relaxing one or two of these constraints; in this ...

Mark Goldenberg; Alexander Kovarsky; Xiaomeng Wu; Jonathan Schaeffer

2003-08-01T23:59:59.000Z

280

Targeted Advertising ... And Privacy Too  

Science Conference Proceedings (OSTI)

The Web presents a rich and powerful tool for aggregation of consumer information. A flurry of recent articles in the popular press has documented aggressive manipulation of such information by some companies for the purposes of targeted advertising. ...

Ari Juels

2001-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

National Ignition Facility Target Chamber  

DOE Green Energy (OSTI)

On June 11, 1999 the Department of Energy dedicated the single largest piece of the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) in Livermore, California. The ten (10) meter diameter aluminum target high vacuum chamber will serve as the working end of the largest laser in the world. The output of 192 laser beams will converge at the precise center of the chamber. The laser beams will enter the chamber in two by two arrays to illuminate 10 millimeter long gold cylinders called hohlraums enclosing 2 millimeter capsule containing deuterium, tritium and isotopes of hydrogen. The two isotopes will fuse, thereby creating temperatures and pressures resembling those found only inside stars and in detonated nuclear weapons, but on a minute scale. The NIF Project will serve as an essential facility to insure safety and reliability of our nation's nuclear arsenal as well as demonstrating inertial fusion's contribution to creating electrical power. The paper will discuss the requirements that had to be addressed during the design, fabrication and testing of the target chamber. A team from Sandia National Laboratories (SNL) and LLNL with input from industry performed the configuration and basic design of the target chamber. The method of fabrication and construction of the aluminum target chamber was devised by Pitt-Des Moines, Inc. (PDM). PDM also participated in the design of the chamber in areas such as the Target Chamber Realignment and Adjustment System, which would allow realignment of the sphere laser beams in the event of earth settlement or movement from a seismic event. During the fabrication of the target chamber the sphericity tolerances had to be addressed for the individual plates. Procedures were developed for forming, edge preparation and welding of individual plates. Construction plans were developed to allow the field construction of the target chamber to occur parallel to other NIF construction activities. This was necessary to achieve the overall schedule. Plans had to be developed for the precise location and alignment of laser beam ports. Upon completion of the fabrication of the aluminum target chamber in a temporary structure the 130 ton sphere was moved from the temporary construction enclosure to its final location in the target building. Prior to the installation of a concrete shield and after completion of the welding of the chamber penetrations vacuum leak checking was performed to insure the vacuum integrity of target chamber. The entire spherical chamber external surface supports a 40 cm thick reinforced concrete shield after installation in the target building. The final task is a total survey of the laser ports and the contour machining of spacer plates so that laser devices attached to these ports meet the alignment criteria.

Wavrik, R W; Cox, J R; Fleming, P J

2000-10-05T23:59:59.000Z

282

Authenticated group Diffie-Hellman key exchange: theory and practice  

SciTech Connect

Authenticated two-party Diffie-Hellman key exchange allows two principals A and B, communicating over a public network, and each holding a pair of matching public/private keys to agree on a session key. Protocols designed to deal with this problem ensure A (B resp.)that no other principals aside from B (A resp.) can learn any information about this value. These protocols additionally often ensure A and B that their respective partner has actually computed the shared secret value. A natural extension to the above cryptographic protocol problem is to consider a pool of principals agreeing on a session key. Over the years several papers have extended the two-party Diffie-Hellman key exchange to the multi-party setting but no formal treatments were carried out till recently. In light of recent developments in the formalization of the authenticated two-party Diffie-Hellman key exchange we have in this thesis laid out the authenticated group Diffie-Hellman key exchange on firmer foundations.

Chevassut, Olivier

2002-10-03T23:59:59.000Z

283

A Key-Distribution Scheme for Wireless Home Automation Networks  

E-Print Network (OSTI)

Wireless home automation networks are one example of how wireless technologies may soon become part of our daily life, yet security in existing products is woefully inadequate. An important problem in this area is the question of secure key distribution. In this paper we present a key-distribution scheme geared towards home automation networks, but applicable to other networks with related properties as well. Our approach uses a decentralized scheme that is designed to work on resource-poor devices, allows easy addition and removal of devices and limits the workload on the end user while guaranteeing the secrecy of the exchanged keys even in the presence of subverted nodes.

Arno Wacker; Timo Heiber; Holger Cermann

2004-01-01T23:59:59.000Z

284

The Electricity Transmission System Opportunities to Overcome Key Challenges  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Opportunities to Overcome Key Challenges Opportunities to Overcome Key Challenges Summary Results of Breakout Group Discussions Electricity Transmission Workshop Double Tree Crystal City, Arlington, Virginia November 2, 2012 Breakout Group Discussion Overview Opportunities to Overcome Key Challenges Each of the four breakout groups prioritized the critical issues facing the grid from the list of synthesized challenges identified in the first breakout session of the workshop. Focusing on these top priorities, each group proposed specific R&D activities and initiatives that DOE can pursue to overcome these challenges and address existing gaps. Summary of Synthesized Challenges A. Need improved understanding of the availability, utility, maintenance, exchange, and security of data and associated requirements.

285

Targets and methods for target preparation for radionuclide production  

DOE Patents (OSTI)

The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti--Sb, Al--Sb, Cu--Sb, or Ni--Sb in order to produce radionuclides (e.g., tin-117 m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.

Zhuikov, Boris L; Konyakhin, Nicolai A; Kokhanyuk, Vladimir M; Srivastava, Suresh C

2012-10-16T23:59:59.000Z

286

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Key Dates Key Dates Science Undergraduate Laboratory Internships (SULI) SULI Home Eligibility Benefits Participant Obligations How to Apply Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A RSS Feeds FeedbackShare Page At the submission deadline (shown in red) the application system will close, and no materials will be accepted after the submission deadline has passed. The Application System closes at 5:00 PM Eastern Time. SULI Internship Term: Spring 2014 Summer 2014* Fall 2013 On-line Application Opens August 6, 2013 October 18, 2013 May 1, 2013 Applications Due October, 1, 2013 5:00 PM ET January 10, 2014 5:00 PM ET June 12, 2013 5:00 PM ET Offer Notification Period Begins on or around October, 15, 2013 January 20, 2014 June 24, 2013

287

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Key Dates Key Dates Visiting Faculty Program (VFP) VFP Home Eligibility Benefits Participant Obligations How to Apply Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A RSS Feeds FeedbackShare Page At the submission deadline (shown in red) the application system will close, and no materials will be accepted after the submission deadline has passed. The Application System closes at 5:00 PM Eastern Time. VFP Term: Summer 2014 On-line Application Opens October 18, 2013 Applications Due January 10, 2014 5:00 PM ET* Offer Notification Period Begins January 20, 2014 All DOE Offers and Notifications Complete April 1, 2014 *A research proposal co-developed with a DOE laboratory researcher must be electronically submitted by all faculty applicants as part of their

288

U-268: Oracle Database Authentication Protocol Discloses Session Key  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

8: Oracle Database Authentication Protocol Discloses Session 8: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users U-268: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users September 26, 2012 - 6:00am Addthis PROBLEM: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users PLATFORM: Oracle Database 11g Releases 1 and 2 ABSTRACT: A vulnerability was reported in Oracle Database. reference LINKS: Darkreading Threatpost Arstechnica Oracle Security Alerts SecurityTracker Alert ID: 1027558 CVE-2012-3137 IMPACT ASSESSMENT: Medium Discussion: The authentication protocol in Oracle Database 11g 1 and 2 allows remote attackers to obtain the session key and salt for arbitrary users, which leaks information about the cryptographic hash and makes it easier to

289

Energy Secretary Bodman Commends Key Milestone In MOX Program | Department  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Commends Key Milestone In MOX Program Commends Key Milestone In MOX Program Energy Secretary Bodman Commends Key Milestone In MOX Program April 1, 2005 - 11:28am Addthis WASHINGTON, DC - In response to the Nuclear Regulatory Commission's (NRC) authorization of the construction of a U.S. Mixed-Oxide (MOX) Fuel Fabrication Facility at the Department of Energy's Savannah River Site in South Carolina, Secretary of Energy Samuel W. Bodman today released the following statement: "Issuing the permit for construction of a MOX facility in South Carolina is the crucial next step in the MOX program. It is a key milestone in our efforts to dispose of surplus weapons grade plutonium in the U.S. and Russia," Secretary Bodman said. "We look forward to proceeding with this nonproliferation program that will ultimately eliminate enough

290

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts December 9, 2009 - 12:00am Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Patricia A. Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, Department of Energy Mari Del Carmen Aponte, Ambassador to the Republic of El Salvador, Department of State Donald E. Booth, Ambassador to the Federal Democratic Republic of Ethiopia, Department of State Larry Persily, Federal Coordinator for Alaska Natural Gas Transportation Projects President Obama said, "The depth of experience these individuals bring to their roles will be valuable to my administration as we work to bring about

291

Department of Energy Announces Key Additions to Public Affairs Staff |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Announces Key Additions to Public Affairs Announces Key Additions to Public Affairs Staff Department of Energy Announces Key Additions to Public Affairs Staff February 26, 2009 - 12:00am Addthis WASHINGTON, DC - Today, the Department of Energy announced key staff additions to the Office Public Affairs: Dan Leistikow, Director of Public Affairs; Tom Reynolds, Deputy Director of Public Affairs; Stephanie Mueller, Press Secretary; and Tiffany Edwards, Deputy Press Secretary. "I am pleased to have these talented individuals join the Department of Energy", said Secretary Steven Chu. "Having worked on President Obama's presidential campaign Dan, Tom, Stephanie and Tiffany bring knowledge about the President's commitment to end our addiction to foreign oil, invest in alternative and renewable energy, address the global climate crisis and

292

U-268: Oracle Database Authentication Protocol Discloses Session Key  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

8: Oracle Database Authentication Protocol Discloses Session 8: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users U-268: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users September 26, 2012 - 6:00am Addthis PROBLEM: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users PLATFORM: Oracle Database 11g Releases 1 and 2 ABSTRACT: A vulnerability was reported in Oracle Database. reference LINKS: Darkreading Threatpost Arstechnica Oracle Security Alerts SecurityTracker Alert ID: 1027558 CVE-2012-3137 IMPACT ASSESSMENT: Medium Discussion: The authentication protocol in Oracle Database 11g 1 and 2 allows remote attackers to obtain the session key and salt for arbitrary users, which leaks information about the cryptographic hash and makes it easier to

293

Table A4. Residential sector key indicators and consumption  

Gasoline and Diesel Fuel Update (EIA)

3 3 U.S. Energy Information Administration | Annual Energy Outlook 2013 Reference case Table A4. Residential sector key indicators and consumption (quadrillion Btu per year, unless otherwise noted) Energy Information Administration / Annual Energy Outlook 2013 Table A4. Residential sector key indicators and consumption (quadrillion Btu per year, unless otherwise noted) Key indicators and consumption Reference case Annual growth 2011-2040 (percent) 2010 2011 2020 2025 2030 2035 2040 Key indicators Households (millions) Single-family ....................................................... 82.85 83.56 91.25 95.37 99.34 103.03 106.77 0.8% Multifamily ........................................................... 25.78 26.07 29.82 32.05 34.54 37.05 39.53 1.4%

294

DOE Announces More Key Administration Posts | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

More Key Administration Posts More Key Administration Posts DOE Announces More Key Administration Posts March 27, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Ray Mabus, Secretary of the Navy, Department of Defense; Donald Remy, General Counsel of the Army, Department of Defense; J. Randolph Babbitt, Administrator, Federal Aviation Administration; Jose D. Riojas, Assistant Secretary for Operations, Security and Preparedness, Department of Veterans Affairs; John Trasviña, Assistant Secretary for Fair Housing and Equal Opportunity, Department of Housing and Urban Development; Lawrence E. Strickling, Assistant Secretary for Communications and Information, Department of Commerce; and Cathy Zoi, Assistant Secretary for Energy Efficiency and

295

LEDSGP/Transportation Toolkit/Key Actions | Open Energy Information  

Open Energy Info (EERE)

source source History View New Pages Recent Changes All Special Pages Semantic Search/Querying Get Involved Help Apps Datasets Community Login | Sign Up Search Page Edit History Facebook icon Twitter icon » LEDSGP/Transportation Toolkit/Key Actions < LEDSGP‎ | Transportation Toolkit(Redirected from Transportation Toolkit/Key Actions) Jump to: navigation, search LEDSGP Logo.png Transportation Toolkit Home Tools Training Contacts Key Actions for Low-Emission Development in Transportation Although no single approach or fixed process exists for low emission development strategies (LEDS), the following key actions are necessary steps for implementing LEDS in the transportation sector. Undertaking these actions requires flexibility to adapt to dynamic societal conditions in a

296

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts June 10, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Joan Evans, Assistant Secretary for Congressional and Legislative Affairs, Department of Veterans Affairs; Warren F. "Pete" Miller, Jr., PhD, Assistant Secretary for Nuclear Energy, Department of Energy; and John R. Norris, Commissioner, Federal Energy Regulatory Commission. President Obama said, "I am grateful that these three impressive individuals will be working with me in these important roles. The commitment of these experienced public servants has made an impression on

297

Key Science and Engineering Indicators: Digest 2012 | Data.gov  

NLE Websites -- All DOE Office Websites (Extended Search)

Key Science and Engineering Indicators: Digest 2012 Key Science and Engineering Indicators: Digest 2012 BusinessUSA Data/Tools Apps Challenges Let's Talk BusinessUSA You are here Data.gov » Communities » BusinessUSA » Data Key Science and Engineering Indicators: Digest 2012 Dataset Summary Description This 2012 digest of key S&E indicators is an interactive tool that draws from the National Science Board's (NSB's) Science and Engineering Indicators report. The digest serves to draw attention to important trends and data points from across Indicators and to introduce readers to the data resources available in the report. Tags {science,engineering,indicators,statistics,nsf,nsb,srs,federal,government,education,labor,employment,workforce,research,development,industry,international,global,r&d,technology,patents,"research citations"}

298

Recommendation for Pair-Wise Key Establishment Schemes ...  

Science Conference Proceedings (OSTI)

... with unilateral key-confirmation from party V to party ... may be a component of a protocol, which in ... Note that protocols, per se, are not specified in this ...

2013-06-05T23:59:59.000Z

299

A linux kernel cryptographic framework: decoupling cryptographic keys from applications  

Science Conference Proceedings (OSTI)

This paper describes a cryptographic service framework for the Linux kernel. The framework enables user-space applications to perform operations with cryptographic keys, while at the same time ensuring that applications cannot directly access or extract ...

Nikos Mavrogiannopoulos; Miloslav Trma?; Bart Preneel

2012-03-01T23:59:59.000Z

300

SLAC National Accelerator Laboratory - LCLS-II Passes Key Milestone...  

NLE Websites -- All DOE Office Websites (Extended Search)

LCLS-II Passes Key Milestone in DOE Approval Process By Glennda Chui November 1, 2011 The Department of Energy has approved a preliminary budget, schedule and design plans for the...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

First look at cellulose's early production could hold keys to...  

NLE Websites -- All DOE Office Websites (Extended Search)

cellulose's early production could hold keys to bacteria-free medical devices, better biofuel By Jared Sagoff * May 14, 2013 Tweet EmailPrint Produced by plants as well as algae...

302

Worldwide Trends in Energy Use and Efficiency: Key Insights from...  

Open Energy Info (EERE)

Worldwide Trends in Energy Use and Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Jump to:...

303

THIS GUIDE IS INTENDED TO PROVIDE KEY INFORMATION to  

NLE Websites -- All DOE Office Websites (Extended Search)

THIS GUIDE IS INTENDED TO PROVIDE KEY INFORMATION to policy makers on energy codes and to offer guidance on how policy makers can support the creation of statewide energy...

304

The use of a logistic map for key generation  

E-Print Network (OSTI)

A key generation scheme is proposed and its performance analyzed. The method, the logistic map scheme (LMS), is applicable for use on wireless networks because it does not require devices to engage in computationally ...

Ando, Megumi, M. Eng. Massachusetts Institute of Technology

2010-01-01T23:59:59.000Z

305

EIA Data: 2011 United States Residential Sector Key Indicators...  

Open Energy Info (EERE)

Residential Sector Key Indicators and Consumption This datasetis the 2011 United...

306

An Implementation of Key-Based Digital Signal Steganography  

Science Conference Proceedings (OSTI)

A real-life requirement motivated this case study of secure covert communication. An independently researched process is described in detail with an emphasis on implementation issues regarding digital images. A scheme using stego keys to create pseudo-random ...

Toby Sharp

2001-04-01T23:59:59.000Z

307

Nano Lect 1 Questions and Keypoints Key Points  

E-Print Network (OSTI)

Nano Lect 1 ­ Questions and Keypoints Key Points 1. What is nano technology: a. Very small technology with device in the 1nm to 100nm lots of useful properties Questions 1. Define nanotechnology. Is an nano

Smy, Tom

308

DOE Announces More Key Administration Posts | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

More Key Administration Posts More Key Administration Posts DOE Announces More Key Administration Posts March 20, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Dr. Steven E. Koonin, Under Secretary for Science, Department of Energy; David Sandalow, Assistant Secretary for Policy and International Affairs, Department of Energy; Ambassador Johnnie Carson, Assistant Secretary for African Affairs, State Department; Kathy Martinez, Assistant Secretary for Disability Employment Policy (ODEP), Department of Labor; Jonathan S. Adelstein, Administrator for the Rural Utilities Service, United States Department of Agriculture; Timothy W. Manning, Deputy Administrator for National Preparedness, FEMA, Department of Homeland Security; and Priscilla

309

Key Activities in Energy Efficiency | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

About » Key Activities in Energy Efficiency About » Key Activities in Energy Efficiency Key Activities in Energy Efficiency The Building Technologies Office conducts work in three key areas in order to continually develop innovative, cost-effective energy saving solutions: research and development (R&D), market stimulation, and building codes and equipment standards. Working with our partners on these activities results in better products, better new homes, better ways to improve older homes, and better buildings in which to work, shop, and lead our everyday lives. Research and Development Spearhead the development of new, energy efficient technologies. Lead R&D activities that reduce home energy use through Building America. Collaborate with industry to improve the energy efficiency of new

310

Interest/Users Group Meeting Proceedings and Key Findings, 2011  

Science Conference Proceedings (OSTI)

This technical update is the summary of the meeting proceedings and key findings for the Fossil Operations and Maintenance Program Area Interest/Users Groups meetings held during 2011. The report represents a culmination of numerous meetings, conferences, users groups, and workshops conducted throughout the year. The document incorporates the meeting logistics and objectives; names of keynote speaker, attendees, and host utility; presentation location, and key findings and recommendations from each meeti...

2011-12-21T23:59:59.000Z

311

Security of quantum key distribution with arbitrary individual imperfections  

E-Print Network (OSTI)

We consider the security of the Bennett-Brassard 1984 (BB84) protocol for Quantum Key Distribution (QKD), with arbitrary individual imperfections simultaneously in the source and detectors. We provide the secure key generation rate, and show that only two parameters must be bounded to ensure security; the basis dependence of the source and a detector blinding parameter. The system may otherwise be completely uncharacterized and contain large losses.

ystein Mary; Lars Lydersen; Johannes Skaar

2009-03-20T23:59:59.000Z

312

Key-and-keyway coupling for transmitting torque  

DOE Patents (OSTI)

The design of an improved key-and-keyway coupling for the transmission of torque is given. The coupling provides significant reductions in stress concentrations in the vicinity of the key and keyway. The keyway is designed with a flat-bottomed u-shaped portion whose inboard end terminates in a ramp which is dished transversely, so that the surface of the ramp as viewed in transverse section defines an outwardly concave arc.

Blue, S.C.; Curtis, M.T.; Orthwein, W.C.; Stitt, D.H.

1975-11-18T23:59:59.000Z

313

Quantum Public-Key Encryption with Information Theoretic Security  

E-Print Network (OSTI)

We propose a definition for the information theoretic security of a quantum public-key encryption scheme, and present bit-oriented and two-bit-oriented encryption schemes satisfying our security definition via the introduction of a new public-key algorithm structure. We extend the scheme to a multi-bitoriented one, and conjecture that it is also information theoretically secure, depending directly on the structure of our new algorithm.

Jiangyou Pan; Li Yang

2010-06-02T23:59:59.000Z

314

W-like bound entangled states and secure key distillation  

E-Print Network (OSTI)

We construct multipartite entangled states with underlying W-type structure satisfying positive partial transpose (PPT) condition under any (N-1)|1 partition. Then we show how to distill N-partite secure key form the states using two different methods: direct application of local filtering and novel random key distillation scheme in which we adopt the idea form recent results on entanglement distillation. Open problems and possible implications are also discussed.

Remigiusz Augusiak; Pawel Horodecki

2008-11-21T23:59:59.000Z

315

Key distillation from Gaussian states by Gaussian operations  

E-Print Network (OSTI)

We study the secrecy properties of Gaussian states under Gaussian operations. Although such operations are useless for quantum distillation, we prove that it is possible to distill a secret key secure against any attack from sufficiently entangled Gaussian states with non-positive partial transposition. Moreover, all such states allow for key distillation, when Eve is assumed to perform finite-size coherent attacks before the reconciliation process.

M. Navascues; J. Bae; J. I. Cirac; M. Lewenstein; A. Sanpera; A. Acin

2004-05-11T23:59:59.000Z

316

Analysis of Assembly Bill 369: Prescription Drugs  

E-Print Network (OSTI)

health treatment; prescription drugs; rehabilitative and habilitative services and devices; laboratory

California Health Benefits Review Program (CHBRP)

2011-01-01T23:59:59.000Z

317

Materials considerations in accelerator targets  

Science Conference Proceedings (OSTI)

Future nuclear materials production and/or the burn-up of long lived radioisotopes may be accomplished through the capture of spallation produced neutrons in accelerators. Aluminum clad-lead and/or lead alloys has been proposed as a spallation target. Aluminum was the cladding choice because of the low neutron absorption cross section, fast radioactivity decay, high thermal conductivity, and excellent fabricability. Metallic lead and lead oxide powders were considered for the target core with the fabrication options being casting or powder metallurgy (PM). Scoping tests to evaluate gravity casting, squeeze casting, and casting and swaging processes showed that, based on fabricability and heat transfer considerations, squeeze casting was the preferred option for manufacture of targets with initial core cladding contact. Thousands of aluminum clad aluminum-lithium alloy core targets and control rods for tritium production have been fabricated by coextrusion processes and successfully irradiated in the SRS reactors. Tritium retention in, and release from the coextruded product was modeled from experimental and operational data. Newly produced tritium atoms were trapped by lithium atoms to form a lithium tritide. The effective tritium pressure required for trap or tritide stability was the equilibrium decomposition pressure of tritium over a lithium tritide-aluminum mixture. The temperature dependence of tritium release was determined by the permeability of the cladding to tritium and the local equilibrium at the trap sites. The model can be used to calculate tritium release from aluminum clad, aluminum-lithium alloy targets during postulated accelerator operational and accident conditions. This paper describes the manufacturing technologies evaluated and presents the model for tritium retention in aluminum clad, aluminum-lithium alloy tritium production targets.

Peacock, H.B. Jr.; Iyer, N.C.; Louthan, M.R. Jr. [Westinghouse Savannah River Co., Aiken, SC (United States). Materials Technology Section

1994-08-01T23:59:59.000Z

318

A robust on-demand path-key establishment framework via random key predistribution for wireless sensor networks  

Science Conference Proceedings (OSTI)

Secure communication is a necessity for some wireless sensor network (WSN) applications. However, the resource constraints of a sensor render existing cryptographic systems for traditional network systems impractical for a WSN. Random key predistribution ...

Guanfeng Li; Hui Ling; Taieb Znati; Weili Wu

2006-04-01T23:59:59.000Z

319

The amphiphilic self-assembling peptide EAK16-I as a potential hydrophobic drug carrier  

Science Conference Proceedings (OSTI)

It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is reported here to be able to stabilize ...

Jing Wang; Fushan Tang; Feng Li; Juan Lin; Yinghui Zhang; Linfang Du; Xiaojun Zhao

2008-01-01T23:59:59.000Z

320

Computer modeling reveals how surprisingly potent hepatitis C drug works  

NLE Websites -- All DOE Office Websites (Extended Search)

Hepatitis C computer modeling Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Method for producing laser targets  

DOE Patents (OSTI)

An apparatus and method for producing deuterium targets or pellets of 25.mu. to 75.mu. diameter. The pellets are sliced from a continuously spun solid deuterium thread at a rate of up to 10 pellets/second. The pellets after being sliced from the continuous thread of deuterium are collimated and directed to a point of use, such as a laser activated combustion or explosion chamber wherein the pellets are imploded by laser energy or laser produced target plasmas for neutral beam injection.

Jarboe, Thomas R. (Oakland, CA); Baker, William R. (Orinda, CA)

1977-01-01T23:59:59.000Z

322

Tracking highly maneuverable targets with unknown behavior  

E-Print Network (OSTI)

for maneuvering target tracking, IEEE Trans. Aerosp.converted measurements for tracking, IEEE Trans. Aerosp.particle filters for tracking a maneuvering target, in

Schell, C; Linder, S P; Zeidler, J R

2004-01-01T23:59:59.000Z

323

Energy Efficiency Targets | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Targets Energy Efficiency Targets Eligibility Utility Program Information Maine Program Type Energy Efficiency Resource Standard In June 2009, Maine enacted the ''Act Regarding...

324

EPA's Target Finder calculator | ENERGY STAR  

NLE Websites -- All DOE Office Websites (Extended Search)

sample in the nation, plus have it normalized for size, operating characteristics, and weather. Target Finder Access ENERGY STAR Target Finder When to use Portfolio Manager instead...

325

Drug Use and Drug Policy in a Prohibition Regime  

E-Print Network (OSTI)

Heroin/opiates MacCoun and Martin - 2/4/2008 - 41 Otherstory_268000326.html. MacCoun and Martin - 2/4/2008 - 29Toward a drugs MacCoun and Martin - 2/4/2008 - 32 and crime

MacCoun, Robert; Martin, Karin D.

2008-01-01T23:59:59.000Z

326

Quantum key distribution using gaussian-modulated coherent states  

E-Print Network (OSTI)

Quantum continuous variables are being explored as an alternative means to implement quantum key distribution, which is usually based on single photon counting. The former approach is potentially advantageous because it should enable higher key distribution rates. Here we propose and experimentally demonstrate a quantum key distribution protocol based on the transmission of gaussian-modulated coherent states (consisting of laser pulses containing a few hundred photons) and shot-noise-limited homodyne detection; squeezed or entangled beams are not required. Complete secret key extraction is achieved using a reverse reconciliation technique followed by privacy amplification. The reverse reconciliation technique is in principle secure for any value of the line transmission, against gaussian individual attacks based on entanglement and quantum memories. Our table-top experiment yields a net key transmission rate of about 1.7 megabits per second for a loss-free line, and 75 kilobits per second for a line with losses of 3.1 dB. We anticipate that the scheme should remain effective for lines with higher losses, particularly because the present limitations are essentially technical, so that significant margin for improvement is available on both the hardware and software.

F. Grosshans; G. Van Assche; J. Wenger; R. Brouri; N. J. Cerf; Ph. Grangier

2003-12-02T23:59:59.000Z

327

Foam shell cryogenic ICF target  

SciTech Connect

A uniform cryogenic layer of DT fuel is maintained in a fusion target having a low density, small pore size, low Z rigid foam shell saturated with liquid DT fuel. Capillary action prevents gravitational slumping of the fuel layer. The saturated shell may be cooled to produce a solid fuel layer.

Darling, Dale H. (Pleasanton, CA)

1987-01-01T23:59:59.000Z

328

Life Pure Fusion Target Designs: Status and Prospects  

Science Conference Proceedings (OSTI)

Analysis and radiation-hydrodynamics simulations for expected high-gain fusion target performance on a demonstration 1-GWe Laser Inertial Fusion Energy (LIFE) power plant are presented. The required laser energy driver is 2.2 MJ at a 0.351-{mu}m wavelength, and a fusion target gain greater than 60 at a repetition rate of 16 Hz is the design goal for economic and commercial attractiveness. A scaling-law analysis is developed to benchmark the design parameter space for hohlraum-driven central hot-spot ignition. A suite of integrated hohlraum simulations is presented to test the modeling assumptions and provide a basis for near-term experimental resolution of the key physics uncertainties on the National Ignition Facility.

Amendt, P; Dunne, M; Ho, D; Lindl, J

2011-10-20T23:59:59.000Z

329

Energy Storage: The Key to a Reliable, Clean Electricity Supply |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Storage: The Key to a Reliable, Clean Electricity Supply Storage: The Key to a Reliable, Clean Electricity Supply Energy Storage: The Key to a Reliable, Clean Electricity Supply February 22, 2012 - 4:52pm Addthis Improved energy storage technology offers a number of economic and environmental benefits. Improved energy storage technology offers a number of economic and environmental benefits. Matthew Loveless Matthew Loveless Data Integration Specialist, Office of Public Affairs What does this project do? ARPA-E's GRIDS program is investing in new technologies that make storing energy cheaper and more efficient. Energy storage isn't just for AA batteries any more. Thanks to investments from the Department's Advanced Research Projects Agency-Energy (ARPA-E), energy storage may soon play a bigger part in our electricity

330

Technology Key to Harnessing Natural Gas Potential | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Technology Key to Harnessing Natural Gas Potential Technology Key to Harnessing Natural Gas Potential Technology Key to Harnessing Natural Gas Potential July 18, 2012 - 3:52pm Addthis Deputy Secretary Daniel Poneman tours Proinlosa Energy Corp. in Houston, Texas. Proinlosa is a company in the wind turbine manufacturing supply chain that develops tower parts and has benefitted from the Production Tax Credit (PTC). | Photo courtesy of Keri Fulton. Deputy Secretary Daniel Poneman tours Proinlosa Energy Corp. in Houston, Texas. Proinlosa is a company in the wind turbine manufacturing supply chain that develops tower parts and has benefitted from the Production Tax Credit (PTC). | Photo courtesy of Keri Fulton. Daniel B. Poneman Daniel B. Poneman Deputy Secretary of Energy What does this project do? Builds on President Obama's call for a new era for American energy

331

Sierra Geothermal's Key Find in Southern Nevada | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Sierra Geothermal's Key Find in Southern Nevada Sierra Geothermal's Key Find in Southern Nevada Sierra Geothermal's Key Find in Southern Nevada July 13, 2010 - 5:17pm Addthis Sierra Geothermal discovered temperatures hot enough for large-scale geothermal energy production at one of its wells near Silver Peak, Nev. | Photo courtesy of Sierra Geothermal Sierra Geothermal discovered temperatures hot enough for large-scale geothermal energy production at one of its wells near Silver Peak, Nev. | Photo courtesy of Sierra Geothermal Paul Lester Communications Specialist for the Office of Energy Efficiency and Renewable Energy In May 2010, Sierra Geothermal determined temperature at the bottom of a well drilled at the company's Alum project near Silver Peak, Nev., was hot enough for commercial-sized geothermal energy production - measured as 147

332

Transportation Energy Futures Study: The Key Results and Conclusions  

Open Energy Info (EERE)

Transportation Energy Futures Study: The Key Results and Conclusions Transportation Energy Futures Study: The Key Results and Conclusions Webinar Home > Groups > OpenEI Community Central Graham7781's picture Submitted by Graham7781(1992) Super contributor 1 May, 2013 - 11:38 This webinar will outline the key results and conclusions from EERE's Transportation Energy Futures study, which highlights underexplored opportunities to reduce petroleum use and greenhouse gas emissions from the U.S. transportation sector. There will be time for questions from attendees at the end of the webinar. Principal Deputy Assistant Secretary Mike Carr will introduce the study and provide context on EERE's transportation energy strategy. In his role with EERE, Mike provides leadership direction on cross-cutting activities in EERE's portfolio. In particular, he is using his experience in policy

333

Sierra Geothermal's Key Find in Southern Nevada | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Sierra Geothermal's Key Find in Southern Nevada Sierra Geothermal's Key Find in Southern Nevada Sierra Geothermal's Key Find in Southern Nevada July 13, 2010 - 5:17pm Addthis Sierra Geothermal discovered temperatures hot enough for large-scale geothermal energy production at one of its wells near Silver Peak, Nev. | Photo courtesy of Sierra Geothermal Sierra Geothermal discovered temperatures hot enough for large-scale geothermal energy production at one of its wells near Silver Peak, Nev. | Photo courtesy of Sierra Geothermal Paul Lester Communications Specialist, Office of Energy Efficiency and Renewable Energy In May 2010, Sierra Geothermal determined temperature at the bottom of a well drilled at the company's Alum project near Silver Peak, Nev., was hot enough for commercial-sized geothermal energy production - measured as 147

334

Florida Keys El Coop Assn, Inc | Open Energy Information  

Open Energy Info (EERE)

Keys El Coop Assn, Inc Keys El Coop Assn, Inc Jump to: navigation, search Name Florida Keys El Coop Assn, Inc Place Florida Utility Id 6443 Utility Location Yes Ownership C NERC Location FRCC NERC FRCC Yes Operates Generating Plant Yes Activity Generation Yes Activity Transmission Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Rate Code 1 - Residential Service Residential Rate Code 2 - Commercial Service (General Service Non-Demand) Commercial Rate Code 3 - Commercial Service (General Service Demand) Commercial Average Rates Residential: $0.1210/kWh Commercial: $0.1220/kWh Industrial: $0.1140/kWh

335

Turn Your Key, Be Idle Free | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Turn Your Key, Be Idle Free Turn Your Key, Be Idle Free Turn Your Key, Be Idle Free April 13, 2010 - 7:30am Addthis Shannon Brescher Shea Communications Manager, Clean Cities Program What activity wastes gasoline, costs money, produces pollutants, and yet doesn't get you anywhere? Idling! And yet, every year, Americans waste 3 billion gallons of fuel by idling their vehicles. Idling is running a vehicle any time that it's not moving. In this condition, the car's fuel economy is exactly zero miles per gallon. Although many people think that restarting the engine too often will wear out the starter, that idea is just an "old husband's tale." In fact, idling places unnecessary wear-and-tear on the engine, and many manufacturers discourage it. Although drivers can't avoid some amount of idling, such as being stuck in

336

Ariz. Rooftops Key to Unlocking the Potential of Distributed Solar |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Ariz. Rooftops Key to Unlocking the Potential of Distributed Solar Ariz. Rooftops Key to Unlocking the Potential of Distributed Solar Ariz. Rooftops Key to Unlocking the Potential of Distributed Solar July 12, 2010 - 3:51pm Addthis APS will install solar photovoltaic panels like these in Castro Valley, Calif. for a pilot project studying distributed energy in Flagstaff, Ariz. | Photo courtesy of APS APS will install solar photovoltaic panels like these in Castro Valley, Calif. for a pilot project studying distributed energy in Flagstaff, Ariz. | Photo courtesy of APS Nestled in the mountains of northern Arizona and just 75 miles from Grand Canyon National Park, the city of Flagstaff, Ariz. is an ideal city for the Arizona Public Service (APS) to pilot a high concentration of solar photovoltaic energy systems. "Flagstaff is unique electrically," says Eran Mahrer, Director of Renewable

337

Property:Specializations, Capabilities, and Key Facility Attributes Not  

Open Energy Info (EERE)

Property Property Edit with form History Facebook icon Twitter icon » Property:Specializations, Capabilities, and Key Facility Attributes Not Covered Elsewhere Jump to: navigation, search Property Name Specializations, Capabilities, and Key Facility Attributes Not Covered Elsewhere Property Type Text Pages using the property "Specializations, Capabilities, and Key Facility Attributes Not Covered Elsewhere" Showing 25 pages using this property. 1 11-ft Wave Flume Facility + Glass window 6 6-ft Wave Flume Facility + Glass window A Alden Large Flume + This is a recirculating flume facility, so a constant velocity can be maintained indefinitely. This allows collection of a much greater amount of data than possible in tow tanks. Alden's biologists are highly experienced in assessing the impacts of generation devices on fish and the facilities allow for accurate testing with fish in a highly controlled environment.

338

SECOQC White Paper on Quantum Key Distribution and Cryptography  

E-Print Network (OSTI)

The SECOQC White Paper on Quantum Key Distribution and Cryptography is the outcome on a thorough consultation and discussion among the participants of the European project SECOQC (www.secoqc.net). This paper is a review article that attempts to position Quantum Key Distribution (QKD) in terms of cryptographic applications. A detailed comparison of QKD with the solutions currently in use to solve the key distribution problem, based on classical cryptography, is provided. We also detail how the work on QKD networks lead within SECOQC will allow the deployment of long-distance secure communication infrastructures based on quantum cryptography. The purpose of the White Paper is finally to promote closer collaboration between classical and quantum cryptographers. We believe that very fruitful research, involving both communities, could emerge in the future years and try to sketch what may be the next challenges in this direction.

Romain Alleaume; Jan Bouda; Cyril Branciard; Thierry Debuisschert; Mehrdad Dianati; Nicolas Gisin; Mark Godfrey; Philippe Grangier; Thomas Langer; Anthony Leverrier; Norbert Lutkenhaus; Philippe Painchault; Momtchil Peev; Andreas Poppe; Thomas Pornin; John Rarity; Renato Renner; Gregoire Ribordy; Michel Riguidel; Louis Salvail; Andrew Shields; Harald Weinfurter; Anton Zeilinger

2007-01-23T23:59:59.000Z

339

Physical key-protected one-time pad  

E-Print Network (OSTI)

We describe an encrypted communication principle that can form a perfectly secure link between two parties without electronically saving either of their keys. Instead, cryptographic key bits are kept safe within the unique mesoscopic randomness of two volumetric scattering materials. We demonstrate how a shared set of patterned optical probes can generate 10 gigabits of statistically verified randomness between a pair of unique 2 cubic millimeter scattering objects. This shared randomness is used to facilitate information-theoretically secure communication following a modified one-time pad protocol. Benefits of volumetric physical storage over electronic memory include the inability to probe, duplicate or selectively reset any random bits without fundamentally altering the entire key space. Beyond the demonstrated communication scheme, our ability to securely couple the randomness contained within two unique physical objects may help strengthen the hardware for a large class of cryptographic protocols, which ...

Horstmeyer, Roarke; Vellekoop, Ivo; Yang, Changhuei

2013-01-01T23:59:59.000Z

340

Worldwide Trends in Energy Use and Efficiency: Key Insights from  

Open Energy Info (EERE)

Worldwide Trends in Energy Use and Efficiency: Key Insights from Worldwide Trends in Energy Use and Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Worldwide Trends in Energy Use and Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Focus Area: Power Plant Efficiency Topics: Potentials & Scenarios Website: www.iea.org/papers/2008/indicators_2008.pdf Equivalent URI: cleanenergysolutions.org/content/worldwide-trends-energy-use-and-effic Language: English Policies: "Regulations,Deployment Programs" is not in the list of possible values (Deployment Programs, Financial Incentives, Regulations) for this property.

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Managing Supply Chain Key for Hawaii Appliance Rebate Program | Department  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Managing Supply Chain Key for Hawaii Appliance Rebate Program Managing Supply Chain Key for Hawaii Appliance Rebate Program Managing Supply Chain Key for Hawaii Appliance Rebate Program August 24, 2010 - 10:00am Addthis Lindsay Gsell Hawaii's appliance rebate program delivered 4,300 rebates to Hawaiians in just three days. And on just the first day of program, almost 4,000 ENERGY STAR qualified refrigerators were sold. Funded by $1.2 million from the American Recovery and Reinvestment Act, the program delivered a proportionate number of $250 ENERGY STAR refrigerator rebates to six of Hawaii's islands: Oahu, Hawaii, Maui, Kauai, Lanai, and Molokai. "It takes a lot of help from manufacturers, distributors, retailers, hauling company, recyclers, advertisers, printers, new reporters, radio stations and television station to create a success story," said Derrick

342

Managing Supply Chain Key for Hawaii Appliance Rebate Program | Department  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Managing Supply Chain Key for Hawaii Appliance Rebate Program Managing Supply Chain Key for Hawaii Appliance Rebate Program Managing Supply Chain Key for Hawaii Appliance Rebate Program August 24, 2010 - 10:00am Addthis Lindsay Gsell Hawaii's appliance rebate program delivered 4,300 rebates to Hawaiians in just three days. And on just the first day of program, almost 4,000 ENERGY STAR qualified refrigerators were sold. Funded by $1.2 million from the American Recovery and Reinvestment Act, the program delivered a proportionate number of $250 ENERGY STAR refrigerator rebates to six of Hawaii's islands: Oahu, Hawaii, Maui, Kauai, Lanai, and Molokai. "It takes a lot of help from manufacturers, distributors, retailers, hauling company, recyclers, advertisers, printers, new reporters, radio stations and television station to create a success story," said Derrick

343

Energy Storage: The Key to a Reliable, Clean Electricity Supply |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Energy Storage: The Key to a Reliable, Clean Electricity Supply Energy Storage: The Key to a Reliable, Clean Electricity Supply Energy Storage: The Key to a Reliable, Clean Electricity Supply February 22, 2012 - 4:52pm Addthis Improved energy storage technology offers a number of economic and environmental benefits. Improved energy storage technology offers a number of economic and environmental benefits. Matthew Loveless Matthew Loveless Data Integration Specialist, Office of Public Affairs What does this project do? ARPA-E's GRIDS program is investing in new technologies that make storing energy cheaper and more efficient. Energy storage isn't just for AA batteries any more. Thanks to investments from the Department's Advanced Research Projects Agency-Energy (ARPA-E), energy storage may soon play a bigger part in our electricity

344

Single, Key Gene Discovery Could Streamline Production of Biofuels |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels August 11, 2011 - 3:51pm Addthis WASHINGTON, DC -- A team of researchers at the Department of Energy's BioEnergy Science Center (BESC) have pinpointed the exact, single gene that controls ethanol production capacity in a microorganism. This discovery could be the missing link in developing biomass crops that produce higher concentrations of ethanol at lower costs. "The Department of Energy relies on the scientific discoveries of its labs and research centers to improve the production of clean energy sources," said Energy Secretary Steven Chu. "This discovery is an important step in developing biomass crops that could increase yield of

345

Building MRV Standards and Capacity in Key Countries | Open Energy  

Open Energy Info (EERE)

MRV Standards and Capacity in Key Countries MRV Standards and Capacity in Key Countries Jump to: navigation, search Name Building MRV Standards and Capacity in Key Countries Agency/Company /Organization World Resources Institute (WRI) Sector Climate Focus Area Renewable Energy Topics Implementation Website http://www.wri.org/topics/mrv Program Start 2011 Program End 2014 Country Brazil, Colombia, Ethiopia, India, South Africa, Thailand South America, South America, Eastern Africa, Southern Asia, Southern Africa, South-Eastern Asia References World Resources Institute (WRI)[1] Program Overview Developing countries will be required to measure, report, and verify (MRV) mitigation actions according to international guidelines, but few have the capacity to do so. The goal of this project is to build the capacity of a

346

Special Presentation: Key Findings from the Barrier Immune Radio  

NLE Websites -- All DOE Office Websites (Extended Search)

Special Presentation: Key Findings from the Barrier Immune Radio Special Presentation: Key Findings from the Barrier Immune Radio Communications Project Speaker(s): Francis Rubinstein Girish Ghatikar Peter Haugen Date: November 29, 2007 - 12:00pm Location: 90-3122 The Barrier Immune Radio Communications (BIRC) Project was established in January 2007 by the Demand Response Emerging Technologies Program (DRETD) to identify radio frequency technologies that could enable the widespread deployment of Demand Response strategies in buildings. Researchers from Lawrence Berkeley National Laboratory and Lawrence Livermore National Laboratory will present the key findings from this project in a one-hour presentation. Researchers found that several of the RF technologies tested at LBNL's Molecular Foundry building were able to provide sufficiently

347

Small Businesses Key in Hydropower Tech Advancement | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Businesses Key in Hydropower Tech Advancement Businesses Key in Hydropower Tech Advancement Small Businesses Key in Hydropower Tech Advancement September 6, 2011 - 2:59pm Addthis Earlier today, the Department of Energy and the Department of Interior announced nearly $17 million in funding over the next three years to advance hydropower technology. The funding announced today will go to sixteen innovative projects around the country, including sustainable small hydro projects, like the ones from Hydro Green Energy, a small business that handles hydroelectric power generation and power and communication line construction. The company, which has eight employees currently, has been awarded funding for two projects. Near Space Systems, a Colorado Springs-based company, is a service-disabled veteran-owned business with a manufacturing focus that's

348

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers http://www.bioportfolio.com/news/article/620380/The-Targeted-Delivery-Of-Multicomponent-Cargos-To-Cancer-Cells-By-Nanoporous-Particle.html[4/21/  

E-Print Network (OSTI)

, Markets And Compani... Complete Target Atlas In Oncology Drug Development: From Tumor T... Reports | Researchers report on the development of a new class of high-capacity drug carrier they claim combines/Oxide Hybrid Electrodes For Electrochemical Supercapacitors Nature | Instant access to this article: US$18 Buy

Brinker, C. Jeffrey

349

Energy Critical Infrastructure and Key Resources Sector-Specific  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Energy Energy Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) May 2007 Department of Energy Energy Sector Government Coordinating Council Letter of Support i ii Energy Sector-Specific Plan (Redacted) Energy Sector Coordinating Councils Letter of Concurrence The National Infrastructure Protection Plan (NIPP) provides the unifying structure for the integration of federal critical infrastructures and key resources (CI/KR) protection efforts into a single national program. The NIPP includes an overall framework integrating federal programs and activities that are currently underway in the various sectors, as well as new and developing CI/KR protection efforts. The Energy

350

LEDSGP/Transportation Toolkit/Key Actions | Open Energy Information  

Open Energy Info (EERE)

Actions Actions < LEDSGP‎ | Transportation Toolkit Jump to: navigation, search LEDSGP Logo.png Transportation Toolkit Home Tools Training Contacts Key Actions for Low-Emission Development in Transportation Although no single approach or fixed process exists for low-emission development strategies (LEDS), the following key actions are necessary steps for implementing LEDS in the transportation sector. Undertaking these actions requires flexibility to adapt to dynamic societal conditions in a way that complements existing climate and development goals in other sectors. Planners, researchers, and decision-makers should customize this LEDS implementation framework for the specific conditions of their transport sector, choosing from relevant resources to achieve a comprehensive action

351

Security bounds for continuous variables quantum key distribution  

E-Print Network (OSTI)

Security bounds for key distribution protocols using coherent and squeezed states and homodyne measurements are presented. These bounds refer to (i) general attacks and (ii) collective attacks where Eve interacts individually with the sent states, but delays her measurement until the end of the reconciliation process. For the case of a lossy line and coherent states, it is first proven that a secure key distribution is possible up to 1.9 dB of losses. For the second scenario, the security bounds are the same as for the completely incoherent attack.

Miguel Navascues; Antonio Acin

2004-07-19T23:59:59.000Z

352

Tomographic Quantum Cryptography: Equivalence of Quantum and Classical Key Distillation  

E-Print Network (OSTI)

The security of a cryptographic key that is generated by communication through a noisy quantum channel relies on the ability to distill a shorter secure key sequence from a longer insecure one. For an important class of protocols, which exploit tomographically complete measurements on entangled pairs of any dimension, we show that the noise threshold for classical advantage distillation is identical with the threshold for quantum entanglement distillation. As a consequence, the two distillation procedures are equivalent: neither offers a security advantage over the other.

Dagmar Bruss; Matthias Christandl; Artur Ekert; Berthold-Georg Englert; Dagomir Kaszlikowski; Chiara Macchiavello

2003-03-31T23:59:59.000Z

353

FY 2012 Highlighted Sustainable Targets and Initiatives  

Energy.gov (U.S. Department of Energy (DOE))

Joint Environmental Management System (EMS) GoalsFY 2012 Highlighted Sustainable Targets and Initiatives

354

Efficient search algorithms for RNAi target detection  

Science Conference Proceedings (OSTI)

RNA interference (RNAi) is a posttranscriptional gene silencing mechanism used to study gene functions, inhibit viral activities, and treat diseases therapeutically. However, RNAi has off-target effects--non-target genes can be unintentionally silenced. ... Keywords: Off-target, RNAi target detection, Reverse string search, String inexact matching, String kernels, siRNA seed region

Shibin Qiu; Terran Lane; Cundong Yang

2007-12-01T23:59:59.000Z

355

TARGETED DRUG DELIVERY TO HUMAN AORTIC SMOOTH MUSCLE CELLS USING BIODEGRADABLE NANOPARTICLES  

E-Print Network (OSTI)

First of all, I would like to thank Dr. Nguyen for giving me an opportunity to work in her laboratory as an undergraduate McNair student; and for allowing me to continue to work for her over the past few years. Without her advice and direction I would not have the appreciation for research as I do today. Moreover, it would have been difficult to complete this project without her dedication. I also thank Dr. Chuong and Dr. Yang for serving as my committee members. Furthermore, I thank each of you for your cooperation in adjusting your schedules to attend my defense. Additionally, I want to thank the students in the Nanomedicine and Tissue laboratory for all of their assistance whenever I was having difficulties and required help, especially those who were available this summer. In particular I would like to thank Maham Rahimi for his guidance over the past few years. Last, but not least, I thank my family because without them I would not be where I am today. I am truly grateful and appreciate all the love and support you given me.

Danyel Specht; Danyel Specht M. S

2008-01-01T23:59:59.000Z

356

Phosphoinositide 3-kinases as drug targets in cancer Len Stephens1  

E-Print Network (OSTI)

, particularly, in the control of proliferation, survival and regulation of the potential oncogene PKB, with several additional PI3K effectors controlling cell proliferation and apoptosis having been described of the activity of a gene, a potential onco- gene, that favours survival, growth and/or proliferation. This can

Williams, Roger L.

357

Monitoring and Targeting (M&T): A Low Investment, Low Risk Approach to Energy Cost Savings  

E-Print Network (OSTI)

Monitoring and Targeting (M&T) is a disciplined approach to energy management that ensures that energy resources are used to their maximum economic advantage. M&T serves two principal functions: Ongoing, day-to-day control of energy use Planned improvements in energy efficiency Key elements of an M&T program include: Measurement of utility (steam, fuel, power) consumption levels The establishment of consumption targets that take variations in key variables (e.g., throughput, conversion, product quality...etc.) into account Comparison of actual vs. target energy usage "Exception reports" to highlight areas experiencing unusually good or unusually poor performance An established protocol, involving both management and operating personnel, for reviewing and acting upon the energy information available. Tracking and reporting of the savings achieved Periodic review and reassessment of the energy targets. This paper briefly reviews key M&T concepts and their application in industrial settings. Practical aspects of program implementation -such as data entry, target setting, report generation, software requirements, and personnel orientation and training -are discussed. Representative savings produced by M&T in a variety of plant types also are presented. These savings typically are achieved with little or no capital investment.

McMullan, A.; Rutkowski, M.; Karp, A.

2001-05-01T23:59:59.000Z

358

Multishell inertial confinement fusion target  

DOE Patents (OSTI)

A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reactions accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

1987-01-01T23:59:59.000Z

359

Multishell inertial confinement fusion target  

DOE Patents (OSTI)

A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reaction accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

1984-01-01T23:59:59.000Z

360

Target preparations and thickness measurements  

SciTech Connect

A wide variety of isotope target preparative methods have been used, including rolling of metals, vapor deposition, electrodeposition, chemical vapor deposition, and sputtering, to obtain thin and thick films of most elements or compounds of elements in the Periodic Table. Most thin films prepared for use in self-supported form as well as those deposited on substrates require thickness measurement (atom count and distribution) and/or thickness uniformity determination before being used in nuclear research. Preparative methods are described together with thickness and uniformity determination procedures applicable to samples being prepared (in situ) and to completed samples. Only nondestructive methods are considered applicable to target samples prepared by the ORNL Solid State Division, Isotope Research Materials Laboratory. Thickness or areal density measurements of sufficient sophistication to yield errors of less than +-1 percent have been achieved with regularity. A statistical analysis procedure is applied which avoids error caused by balance zero-point drift in direct weight measurement methods. (auth)

Adair, H.L.; Kobisk, E.H.

1975-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Coherent Communications, Imaging and Targeting  

SciTech Connect

Laboratory and field demonstration results obtained as part of the DARPA-sponsored Coherent Communications, Imaging and Targeting (CCIT) program are reviewed. The CCIT concept uses a Phase Conjugation Engine based on a quadrature receiver array, a hologram processor and a spatial light modulator (SLM) for high-speed, digital beam control. Progress on the enabling MEMS SLM, being developed by a consortium consisting of LLNL, academic institutions and small businesses, is presented.

Stappaerts, E; Baker, K; Gavel, D; Wilks, S; Olivier, S; Brase, J; Olivier, S; Brase, J

2003-10-03T23:59:59.000Z

362

KeyTex Energy LLC | Open Energy Information  

Open Energy Info (EERE)

KeyTex Energy LLC KeyTex Energy LLC Jump to: navigation, search Name KeyTex Energy LLC Place Greensburg, Pennsylvania Zip 15601 Product KeyTex Energy is a full service energy and consulting company, helping businesses implement both wholesale and retail strategies to control and reduce energy costs as well as manage the risks and complexities associated with the energy markets. Coordinates 40.299245°, -79.543159° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.299245,"lon":-79.543159,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

363

The S/KEY One-Time Password System  

Science Conference Proceedings (OSTI)

This document describes the S/KEY* One-Time Password system as released for public use by Bellcore and as described in reference [3]. A reference implementation and documentation are available by anonymous ftp from ftp.bellcore.com in the directories ...

N. Haller

1995-02-01T23:59:59.000Z

364

Quantum Key Distribution and String Oblivious Transfer in Noisy Channels  

Science Conference Proceedings (OSTI)

We prove the unconditional security of a quantum key distribution (QKD) protocol on a noisy channel against the most general attack allowed by quantum physics. We use the fact that in a previous paper we have reduced the proof of the unconditionally ...

Dominic Mayers

1996-08-01T23:59:59.000Z

365

The Key Renewal Theorem for a Transient Markov Chain  

E-Print Network (OSTI)

We consider a time-homogeneous Markov chain $X_n$, $n\\ge0$, valued in ${\\bf R}$. Suppose that this chain is transient, that is, $X_n$ generates a $\\sigma$-finite renewal measure. We prove the key renewal theorem under condition that this chain has asymptotically homogeneous at infinity jumps and asymptotically positive drift.

Korshunov, Dmitry

2007-01-01T23:59:59.000Z

366

Essential lack of security proof in quantum key distribution  

E-Print Network (OSTI)

All the currently available unconditional security proofs on quantum key distribution, in particular for the BB84 protocol and its variants including continuous-variable ones, are invalid or incomplete at many points. In this paper we discuss some of the main known problems, particularly those on operational security guarantee and error correction. Most basic are the points that there is no security parameter in such protocols and it is not the case the generated key is perfect with probability $\\geq 1-\\epsilon$ under the trace distance criterion $d\\leq\\epsilon$, which is widely claimed in the technical and popular literature. The many serious security consequences of this error about the QKD generated key would be explained, including practical ramification on achievable security levels. It will be shown how the error correction problem alone may already defy rigorous quantitative analysis. Various other problems would be touched upon. It is pointed out that rigorous security guarantee of much more efficient quantum cryptosystems may be obtained by abandoning the disturbance-information tradeoff principle and utilizing instead the known KCQ (keyed communication in quantum noise) principle in conjunction with a new DBM (decoy bits method) principle that will be detailed elsewhere.

Horace P. Yuen

2013-10-02T23:59:59.000Z

367

Illustrated plant identification keys: An interactive tool to learn botany  

Science Conference Proceedings (OSTI)

An Interactive Dichotomous Key (IDK) for 390 taxa of vascular plants from the Ria de Aveiro, available on a website, was developed to help teach botany to school and universitary students. This multimedia tool includes several links to Descriptive and ... Keywords: Applications in subject areas, Post-secondary education, Secondary education, Teaching/learning strategies

Helena Silva; Rosa Pinho; Lsia Lopes; Antnio J. A. Nogueira; Paulo Silveira

2011-05-01T23:59:59.000Z

368

A Verifiable Random Function With Short Proofs and Keys  

E-Print Network (OSTI)

construction of a verifiable ran- dom function (VRF) on groups equipped with a bilinear mapping. Our to a VRF in contrast to prior works of Micali-Rabin-Vadhan [MRV99] and Lysyanskaya [Lys02]. Our proofs in [BB04a] to construct an identity based encryption scheme. Our VRF's proofs and keys have constant size

Dodis, Yevgeniy

369

A Verifiable Random Function With Short Proofs and Keys  

E-Print Network (OSTI)

#cient construction of a verifiable ran­ dom function (VRF) on groups equipped with a bilinear mapping. Our to a VRF in contrast to prior works of Micali­Rabin­Vadhan [MRV99] and Lysyanskaya [Lys02]. Our proofs in [BB04a] to construct an identity based encryption scheme. Our VRF's proofs and keys have constant size

Dodis, Yevgeniy

370

Verifiable Random Functions from Identity-Based Key Encapsulation  

Science Conference Proceedings (OSTI)

We propose a methodology to construct verifiable random functions from a class of identity based key encapsulation mechanisms (IB-KEM) that we call VRF suitable. Informally, an IB-KEM is VRF suitable if it provides what we call unique decryption ...

Michel Abdalla; Dario Catalano; Dario Fiore

2009-04-01T23:59:59.000Z

371

A Veri able Random Function With Short Proofs and Keys  

E-Print Network (OSTI)

?? Abstract. We give a simple and e?cient construction of a veri#12;able random function (VRF) on bilinear groups. Our construction is direct. In contrast to prior VRF constructions [MRV99, Lys02], it avoids reasonable given cur- rent state of knowledge. For small message spaces, our VRF's proofs and keys have

372

What were the key energy commodity price trends in 2011?  

Reports and Publications (EIA)

Energy commodity price trends varied widely during 2011. Crude oil and petroleum products prices increased during 2011, while natural gas, coal, and electricity prices declined. This article provides an overview of key energy commodity price trends in 2011 based on prices seen in futures markets.

2012-02-14T23:59:59.000Z

373

Robust secret key based authentication scheme using smart cards  

Science Conference Proceedings (OSTI)

User authentication is an important part of security, along with confidentiality and integrity, for systems that allow remote access over untrustworthy networks, like the Internet. Recently, Chen et al. proposed an improvement on the SAS-like password ... Keywords: authentication, cryptography, secret key, smart card

Eun-Jun Yoon; Kee-Young Yoo

2005-11-01T23:59:59.000Z

374

An improved anonymous authentication and key exchange scheme  

Science Conference Proceedings (OSTI)

Nowadays, anonymity property of user authentication scheme becomes important. In 2003, Park et al. proposed an authentication and key exchange scheme using smart card. However, Juang et al. pointed out that Park et al.'s scheme did not provide the user ...

Kyung-kug Kim; Myung-Hwan Kim

2012-09-01T23:59:59.000Z

375

Quantum key distribution system clocked at 2 GHz  

E-Print Network (OSTI)

An improved quantum key distribution test system operating at clock rates of up to 2GHz using a specially adapted commercially available silicon single photon avalanche diode is presented. The use of improved detectors has improved the fibre-based test system performance in terms of transmission distance and quantum bit error rate.

K. J. Gordon; V. Fernandez; G. S. Buller; I. Rech; S. D. Cova; P. D. Townsend

2006-05-08T23:59:59.000Z

376

Extracting Key Factors to Design Applications in Ambient Intelligence Environment  

Science Conference Proceedings (OSTI)

In an ambient intelligence environment, the design of applications influences the users behavior heavily. The purpose of this paper is to provide key factors considered necessary in developing those applications. We developed four applications applied ... Keywords: ambient feedback, persuasive technology, behavior modification, emotional engagement

Hiroaki Kimura; Tatsuo Nakajima

2008-12-01T23:59:59.000Z

377

The Key Coal Producers ONLINE SUPPORTING MATERIALS to  

E-Print Network (OSTI)

The Key Coal Producers ONLINE SUPPORTING MATERIALS to A Global Coal Production Forecast with Multi's most important coal-producing area is North-Central China. The provinces of Inner Mongolia, Ningxia, Shaanxi and Shanxi together accounted for 83 percent of China's proven coal reserves in 2000, and Shanxi

Patzek, Tadeusz W.

378

Page 1 of 4 Creating and Submitting a Key Request  

E-Print Network (OSTI)

of employees. Enter search criteria in the search fields available and select the down red arrow to filter the terms. #12;Page 3 of 4 13. On the Key Request Form - Room List windowpane, select Add New. 14 use the Select Drawing button after entering the building and floor to display the floor plan

Howitt, Ivan

379

news and views A key issue for hydrogen storage materi-  

E-Print Network (OSTI)

news and views A key issue for hydrogen storage materi- als is that the hydrogenation and dehydro be possible to discover stable hydrogen hydrates with higher storage Hydrogen Posture Plan www.eere.energy.gov/hydrogenandfuelcells/pdfs/ hydrogen_posture_plan.pdf 7. Kuhs, W

Palumbi, Stephen

380

BURNING PLASMA NEXT STEPS: DISCUSSION OF KEY DEVELOPMENTS  

E-Print Network (OSTI)

BURNING PLASMA NEXT STEPS: DISCUSSION OF KEY DEVELOPMENTS Gerald A. Navratil Columbia University/FESAC Burning Plasma Strategy Dec 2002 NRC/NAS Interim Report on Burning Plasmas Jan 30, 2003 DOE of the physics of burning plasma, advance fusion technology, and contribute to the development of fusion energy

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Key issues in ITER diagnostics: Problems and solutions (invited)  

Science Conference Proceedings (OSTI)

The key problems associated with designing diagnostic systems for the International Thermonuclear Experimental Reactor (ITER) are identified and representative solutions are described. The plans for dealing with some outstanding issues are briefly presented. The detailed work is specific to the ITER

A. E. Costley; Members of the ITER Joint Central Team and Home Teams

1999-01-01T23:59:59.000Z

382

Quantum key distribution with a reference quantum state  

SciTech Connect

A new quantum key distribution protocol stable at arbitrary losses in a quantum communication channel has been proposed. For the stability of the protocol, it is of fundamental importance that changes in states associated with losses in the communication channel (in the absence of the eavesdropper) are included in measurements.

Molotkov, S. N., E-mail: molotkov@issp.ac.ru [Russian Academy of Sciences, Institute of Solid State Physics (Russian Federation)

2011-11-15T23:59:59.000Z

383

Generic Security Proof of Quantum Key Exchange using Squeezed States  

E-Print Network (OSTI)

Recently, a Quantum Key Exchange protocol that uses squeezed states was presented by Gottesman and Preskill. In this paper we give a generic security proof for this protocol. The method used for this generic security proof is based on recent work by Christiandl, Renner and Ekert.

Karin Poels; Pim Tuyls; Berry Schoenmakers

2005-08-09T23:59:59.000Z

384

A simple threshold authenticated key exchange from short secrets  

Science Conference Proceedings (OSTI)

This paper brings the password-based authenticated key exchange (PAKE) problem closer to practice. It takes into account the presence of firewalls when clients communicate with authentication servers. An authentication server can indeed be seen as two ... Keywords: password-based authentication, threshold protocols

Michel Abdalla; Olivier Chevassut; Pierre-Alain Fouque; David Pointcheval

2005-12-01T23:59:59.000Z

385

Key website factors in e-business strategy  

Science Conference Proceedings (OSTI)

The design of a quality website, as part of e-business strategy, has become a key element for success in the online market. This article analyzes the main factors that must be taken into account when designing a commercial website, concentrating on the ... Keywords: Accessibility, Content, Navigability, Speed, Web Assessment Index (WAI), Website

Blanca HernNdez; Julio JimNez; M. Jos MartN

2009-10-01T23:59:59.000Z

386

Packaging for a drug delivery microelectromechanical system  

E-Print Network (OSTI)

Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

Ho Duc, Hong Linh, 1978-

2005-01-01T23:59:59.000Z

387

The pipeline and future of drug development in schizophrenia  

E-Print Network (OSTI)

The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

Gray, J A; Roth, B L

2007-01-01T23:59:59.000Z

388

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

389

source_target+_rev11.PDF  

NLE Websites -- All DOE Office Websites (Extended Search)

4-1 - April 15 4-1 - April 15 th , 2000 4. Target System and Support Facility 4.1 Overview The target facility extends from the pre-target primary beam focusing to the end of the decay channel. Technical components include the target, beam absorber, and solenoid magnetic field focusing system. While the ultimate goal is to target approximately 4 MW of proton beam in the target area, smaller values and different target materials (low Z etc.) are considered for the first phase of operation. Chosen initially is a carbon target with incident primary beam power of 1.5 MW. The target is embedded in a high field solenoid magnet of 20 Tesla, and followed by a matching section channel, where the field tapers down to 1.25 T. An iterative design process has been carried out in optimizing Monte

390

LIFE Target Fabrication Research Plan Sept 2008  

SciTech Connect

The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

2008-11-10T23:59:59.000Z

391

TYPiMatch: type-specific unsupervised learning of keys and key values for heterogeneous web data integration  

Science Conference Proceedings (OSTI)

Instance matching and blocking, a preprocessing step used for selecting candidate matches, require determining the most representative attributes of instances called keys, based on which similarities between instances are computed. We show that for the ... Keywords: heterogeneous web data, information integration, unsupervised learning

Yongtao Ma; Thanh Tran

2013-02-01T23:59:59.000Z

392

Key computational modeling issues in Integrated Computational Materials Engineering  

Science Conference Proceedings (OSTI)

Designing materials for targeted performance requirements as required in Integrated Computational Materials Engineering (ICME) demands a combined strategy of bottom-up and top-down modeling and simulation which treats various levels of hierarchical material ... Keywords: Databases, ICME, Materials design, Multiscale modeling, Uncertainty

Jitesh H. Panchal; Surya R. Kalidindi; David L. Mcdowell

2013-01-01T23:59:59.000Z

393

Independent Oversight Targeted Review, Sandia National Laboratories -  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Targeted Review, Sandia National Laboratories Targeted Review, Sandia National Laboratories - November 2013 Independent Oversight Targeted Review, Sandia National Laboratories - November 2013 December 2013 Targeted Review of Activity-Level Implementation of Radiological Controls at Sandia National Laboratories This report documents the results of an independent oversight targeted review of radiological protection program activity-level implementation for Sandia National Laboratories (SNL), Technical Area V facilities. SNL is managed by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, under contract to the Department of Energy (DOE) and is overseen by the National Nuclear Security Administration and its Sandia Field Office. This targeted review was performed at SNL September 23-27,

394

Key West, Florida: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

(Redirected from Key West, FL) (Redirected from Key West, FL) Jump to: navigation, search Equivalent URI DBpedia Coordinates 24.5557025°, -81.7825914° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":24.5557025,"lon":-81.7825914,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

395

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

July 27, 2011 - 3:25pm July 27, 2011 - 3:25pm Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: David Danielson - Assistant Secretary for Energy Efficiency and Renewable Energy, Department of Energy Dot Harris - Director of the Office of Minority Economic Impact, Department of Energy President Obama said, "I am honored that these talented individuals have decided to join this Administration and serve our country. I look forward to working with them in the months and years to come." President Obama announced his intent to nominate the following individuals to key Administration posts: David Danielson, Nominee for Assistant Secretary for Energy Efficiency and Renewable Energy, Department of Energy

396

Key Accomplishments @ Catalysis: Reactivity and Structure Group | Chemistry  

NLE Websites -- All DOE Office Websites (Extended Search)

Recent Key Accomplishments Recent Key Accomplishments WGS: Importance of the Metal-Oxide Interface in Catalysis: In Situ Studies of the Water-Gas Shift Reaction by Ambient-Pressure X-ray Photoelectron Spectroscopy A New Type of Strong Metal-Support Interaction and the Production of H-2 through the Transformation of Water on Pt/CeO2(111) and Pt/CeOx/TiO2(110) Catalysts In situ studies of CeO2-supported Pt, Ru, and Pt-Ru alloy catalysts for the water-gas shift reaction: Active phases and reaction intermediates In situ/operando studies for the production of hydrogen through the water-gas shift on metal oxide catalysts Mechanistic understanding of WGS catalysts from first principles: Au(111) Supported Oxide Nanoparticles Theoretical catalyst optimization of WGS catalysts: Cu(111) supported oxide nanostructures

397

Contributions to Key Energy Conversion Technologies and Advanced Methods  

NLE Websites -- All DOE Office Websites (Extended Search)

Contributions to Key Energy Conversion Technologies and Advanced Methods Contributions to Key Energy Conversion Technologies and Advanced Methods for Optimum Energy Systems Design and Planning Speaker(s): Daniel Favrat Date: February 27, 2003 - 12:00pm Location: Bldg. 90 Seminar Host/Point of Contact: Kristina LaCommare This presentation reviews some of EPFL-LENI's recent contributions to advanced cogeneration and heat pump technologies as well as to new system design approaches based on multimodal evolutionar algorithms. In the field of cogeneration, theoretical and experimental results show that gas engines with unscavenged ignition prechambers can, without the need of a catalyst, achieve high efficiencies with reasonable emissions with both natural gas and biogas. Combination with Organic Rankine Cycle (ORC) heat recovery

398

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

January 23, 2012 - 8:28pm January 23, 2012 - 8:28pm Addthis THE WHITE HOUSE Office of the Press Secretary FOR IMMEDIATE RELEASE January 23, 2012 President Obama Announces More Key Administration Posts WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Erin C. Conaton - Under Secretary of Defense for Personnel and Readiness, Department of Defense Scott H. DeLisi - Ambassador to the Republic of Uganda, Department of State Deborah Delisle - Assistant Secretary for Elementary and Secondary Education, Department of Education Tracey Ann Jacobson - Ambassador to the Republic of Kosovo, Department of State James J. Jones - Assistant Administrator for Toxic Substances, Environmental Protection Agency Frank Kendall III - Under Secretary of Defense for Acquisition,

399

Quantum key distribution using intra-particle entanglement  

E-Print Network (OSTI)

We propose the use of intra-particle entanglement to enhance the security of a practical implementation of the Bennett-Brassard-1984 (BB84) quantum key distribution scheme. Intra-particle entanglement is an attractive resource since it can be easily generated using only linear optics. Security is studied under a simple model of incoherent attack for protocols involving two or all five mutually unbiased bases. In terms of efficiency of secret key generation and tolerable error rate, the latter is found to be superior to the former. We find that states that allow secrecy distillation are necessarily entangled, though they may be local. Since more powerful attacks by Eve obviously exist, our result implies that security is a strictly stronger condition than entanglement for these protocols.

S. Adhikari; Dipankar Home; A. S. Majumdar; A. K. Pan; Akshata Shenoy H.; R. Srikanth

2011-01-04T23:59:59.000Z

400

Public key Steganography Using Discrete Cross-Coupled Chaotic Maps  

E-Print Network (OSTI)

By cross-coupling two logistic maps a novel method is proposed for the public key steganography in JPEG image. Chaotic maps entail high complexity in the used algorithm for embedding secret data in a medium. In this paper, discrete cross- coupled chaotic maps are used to specifying the location of the different parts of the secret data in the image. Modifying JPEG format during compressing and decompressing, and also using public key enhanced difficulty of the algorithm. Simulation results show that in addition to excessive capacity, this method has high robustness and resistance against hackers and can be applicable in secret communication. Also the PSNR value is high compared to the other works.

Sodeif Ahadpour; Mahdiyeh Majidpour; Yaser Sadra

2012-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

August 2, 2011 - 9:20pm August 2, 2011 - 9:20pm Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Ashton B. Carter - Nominee for Deputy Secretary of Defense, Department of Defense I. Charles McCullough III - Inspector General of the Intelligence Community, Office of the Director of National Intelligence Ernest Mitchell, Jr. - Administrator, United States Fire Administration, Federal Emergency Management Agency, Department of Homeland Security Nancy M. Ware - Director, Court Services and Offender Supervision Agency for the District of Columbia Gregory H. Woods - General Counsel, Department of Energy The President also announced his intent to appoint the following individuals to key Administration posts:

402

THIS GUIDE IS INTENDED TO PROVIDE KEY INFORMATION to  

NLE Websites -- All DOE Office Websites (Extended Search)

THIS GUIDE IS INTENDED TO PROVIDE KEY INFORMATION to THIS GUIDE IS INTENDED TO PROVIDE KEY INFORMATION to policy makers on energy codes and to offer guidance on how policy makers can support the creation of statewide energy efficiency goals and standards. In addition, this guide will help instruct policy makers on how they can: » Encourage the adoption of statewide codes. » Establish energy code awareness programs. » Support enforcement of and compliance with energy codes. » Participate in the development of national codes and standards. » Determine the viability of the new code. Building TECHnOlOgiES PROgRAM Resource Guide for Policy Makers PREPAREd By Building Energy Codes Program The u.S. department of Energy's (uSdOE) Building Energy Codes Program (BECP) is an information resource on national energy codes. They work with other government

403

Extensible router for multi-user quantum key distribution network  

E-Print Network (OSTI)

A feasible quantum key distribution (QKD) network scheme has been proposed with the wavelength routing. An apparatus called "quantum router", which is made up of many wavelength division multiplexers, can route the quantum signals without destroying their quantum states. Combining with existing point-to-point QKD technology, we can setup a perfectly QKD star-network. A simple characteristic and feasibility of this scheme has also been obtained.

Zhang, T; Han, Z F; Mo, X F; Guo, Guang-Can; Han, Zheng-Fu; Mo, Xiao-Fan; Zhang, Tao

2006-01-01T23:59:59.000Z

404

Key Factors in Displacement Ventilation Systems for Better IAQ  

E-Print Network (OSTI)

This paper sets up a mathematical model of three-dimensional steady turbulence heat transfer in an air-conditioned room of multi-polluting heat sources. Numerical simulation helps identify key factors in displacement ventilation systems that affect air-quality in rooms of multi-polluting heat sources. Results show that it is very important to determine the suitable air-intemperature , air-inflow, and heat source quantity and dispersion, to obtain better displacement ventilation results.

Wang, X.; Chen, J.; Li, Y.; Wang, Z.

2006-01-01T23:59:59.000Z

405

Key management and encryption under the bounded storage model.  

SciTech Connect

There are several engineering obstacles that need to be solved before key management and encryption under the bounded storage model can be realized. One of the critical obstacles hindering its adoption is the construction of a scheme that achieves reliable communication in the event that timing synchronization errors occur. One of the main accomplishments of this project was the development of a new scheme that solves this problem. We show in general that there exist message encoding techniques under the bounded storage model that provide an arbitrarily small probability of transmission error. We compute the maximum capacity of this channel using the unsynchronized key-expansion as side-channel information at the decoder and provide tight lower bounds for a particular class of key-expansion functions that are pseudo-invariant to timing errors. Using our results in combination with Dziembowski et al. [11] encryption scheme we can construct a scheme that solves the timing synchronization error problem. In addition to this work we conducted a detailed case study of current and future storage technologies. We analyzed the cost, capacity, and storage data rate of various technologies, so that precise security parameters can be developed for bounded storage encryption schemes. This will provide an invaluable tool for developing these schemes in practice.

Draelos, Timothy John; Neumann, William Douglas; Lanzone, Andrew J.; Anderson, William Erik

2005-11-01T23:59:59.000Z

406

On target tracking with binary proximity sensors  

Science Conference Proceedings (OSTI)

We consider the use of binary proximity sensors for tracking targets. Such sensors provide only 1-bit information regarding a target's presence or absence in their vicinity, albeit with less than 100% reliability. A novel tracking method employing such ...

Wooyoung Kim; Kirill Mechitov; Jeung-Yoon Choi; Soo Ham

2005-04-01T23:59:59.000Z

407

Nanoparticles for targeting the infarcted heart  

E-Print Network (OSTI)

We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in ...

Dvir, Tal

408

Targets and processes for fabricating same  

DOE Patents (OSTI)

In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

Cowan, Thomas (Dresden, DE); Malekos, Steven (Reno, NV); Korgan, Grant (Reno, NV); Adams, Jesse (Reno, NV); Sentoku, Yasuhiko (Reno, NV); Le Galloudec, Nathalie (Reno, NV); Fuchs, Julien (Paris, FR)

2012-07-24T23:59:59.000Z

409

Range resolution of unequal strength targets  

E-Print Network (OSTI)

This paper examines the problem of resolving targets whose amplitudes may differ. A common metric used for resolution that assumes targets of equal strength is modified for the subject scenario. An expression for range ...

Carlson, Blair D.

410

Workshop on polarized targets and materials. Summary  

DOE Green Energy (OSTI)

Summaries are given of presentations of developments in: irradiated ammonia; polarized atomic hydrogen; polarized target technology; and chemical doping. (GHT)

Hill, D.

1982-01-01T23:59:59.000Z

411

Ninth target fabrication specialists` meeting: Proceedings  

Science Conference Proceedings (OSTI)

This report contains a collection of viewgraphs and short papers on target fabrication for inertial confinement purposes.

Not Available

1993-12-31T23:59:59.000Z

412

The Target Market for Methanol Fuel  

E-Print Network (OSTI)

be to place a surcharge on dirtier fuels (e g gasoline) as asurcharge specifically targeted to supporting cleaner fuels and

Sperling, Daniel

1995-01-01T23:59:59.000Z

413

Targeted Mutagenesis Tool in Mesophilic Cellulolytic ...  

Biomass and Biofuels Targeted Mutagenesis Tool in Mesophilic Cellulolytic Clostridia Species Oak Ridge National Laboratory. Contact ORNL About This ...

414

Potential Prognostic Markers and Therapeutic Targets for ...  

Biofuels; Biotechnology & Medicine. Diagnostics and Therapeutics; ... A Fundamental Prognostic Marker and Therapeutic Target for Metastatic Breast Cancer, IB-2186;

415

Target tracking with binary proximity sensors  

Science Conference Proceedings (OSTI)

We explore fundamental performance limits of tracking a target in a two-dimensional field of binary proximity sensors, and design algorithms that attain those limits while providing minimal descriptions of the estimated target trajectory. Using geometric ... Keywords: Sensor networks, binary sensing, distributed algorithms, fundamental limits, target tracking

Nisheeth Shrivastava; Raghuraman Mudumbai; Upamanyu Madhow; Subhash Suri

2009-11-01T23:59:59.000Z

416

Automated laser fusion target production concept  

SciTech Connect

A target production concept is described for the production of multilayered cryogenic spherical inertial confinement fusion targets. The facility is to deliver targets to the reactor chamber at rates up to 10 per second and at costs consistent with economic production of power.

Hendricks, C.D.

1977-10-04T23:59:59.000Z

417

OMEGA Laser System completes 20,000th target shot | National Nuclear  

NLE Websites -- All DOE Office Websites (Extended Search)

OMEGA Laser System completes 20,000th target shot | National Nuclear OMEGA Laser System completes 20,000th target shot | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > OMEGA Laser System completes 20,000th target shot OMEGA Laser System completes 20,000th target shot Posted By Office of Public Affairs OMEGA Laser The OMEGA Laser System, a key asset for NNSA's stockpile

418

JGI - 2009 Genome Sequencing Targets  

NLE Websites -- All DOE Office Websites (Extended Search)

July 2, 2008 July 2, 2008 Pine Tree, Boat-Boring Bivalve "Bugs", Duck Weed, Oil-Producing Microalgae, Stinkbird Gut, 40 Others Top DOE Joint Genome Institute 2009 Genome Sequencing Targets WALNUT CREEK, CA-In the continuing effort to tap the vast, unexplored reaches of the earth's microbial and plant domains for bioenergy and environmental applications, the DOE Joint Genome Institute (DOE JGI) has announced its latest portfolio of DNA sequencing projects that it will undertake in the coming year. The 44 projects, culled from nearly 150 proposals received through the Community Sequencing Program (CSP), represent over 60 billion nucleotides of data to be generated through this biodiversity sampling campaign-roughly the equivalent of 20 human genomes. "The scientific and technological advances enabled by the information

419

Synchronous identification of friendly targets  

DOE Patents (OSTI)

A synchronous communication targeting system for use in battle. The present invention includes a transceiver having a stabilizing oscillator, a synchronous amplifier and an omnidirectional receiver, all in electrical communication with each other. A remotely located beacon is attached to a blackbody radiation source and has an amplitude modulator in electrical communication with a optical source. The beacon's amplitude modulator is set so that the optical source transmits radiation frequency at approximately the same or lower amplitude than that of the blackbody radiation source to which the beacon is attached. The receiver from the transceiver is adapted to receive frequencies approximately at or below blackbody radiation signals and sends such signals to the synchronous amplifier. The synchronous amplifier then rectifies and amplifies those signals which correspond to the predetermined frequency to therefore identify whether the blackbody radiation source is friendly or not.

Telle, John M. (126 Shady Oak Cir., Tijeras, NM 87059); Roger, Stutz A. (5 Kiowa La., Los Alamos, NM 87544)

1998-01-01T23:59:59.000Z

420

Transformational Energy Action Management (TEAM) Wireless Energy Efficiency Keys Initiative  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

by by Transformational Energy Action Management (TEAM) Wireless Energy Efficiency Keys Initiative *Ways of Using Wireless Technology to Help You Reduce Energy Usage at your Facility Together with our industry partners, we strive to: * Accelerate adoption of the many energy-efficient technologies and practices available today * Conduct vigorous technology innovation to radically improve future energy diversity, resource efficiency, and carbon mitigation * Promote a corporate culture of energy efficiency and carbon management What Is the Industrial Technologies Program ? The Industrial Technologies Program (ITP) is the lead federal agency responsible for improving energy efficiency in the largest energy-using sector of the country. Industrial Sector National Initiative

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Local structures - key to improved gas adsorption in carbon materials |  

NLE Websites -- All DOE Office Websites (Extended Search)

Functional Materials for Energy Functional Materials for Energy Local structures - key to improved gas adsorption in carbon materials September 23, 2013 (Inset, top left) A simulated disordered carbon structure. (Inset, bottom right) Same structure, with dense colored regions showing the strongest adsorption positions. (Main figure) Isosteric heat of adsorption as a function of carbon density, showing the strong change of adsorption with pore size. Combined results from electron microscopy, neutron scattering, and theory, illustrate the link between local structures and adsorption properties in carbon materials. The achieved understanding at the atomic scale is a crucial step towards predicting and designing materials with enhanced gas adsorption properties, with important implications for applications such as

422

Numerical analysis of decoy state quantum key distribution protocols  

SciTech Connect

Decoy state protocols are a useful tool for many quantum key distribution systems implemented with weak coherent pulses, allowing significantly better secret bit rates and longer maximum distances. In this paper we present a method to numerically find optimal three-level protocols, and we examine how the secret bit rate and the optimized parameters are dependent on various system properties, such as session length, transmission loss, and visibility. Additionally, we show how to modify the decoy state analysis to handle partially distinguishable decoy states as well as uncertainty in the prepared intensities.

Harrington, Jim W [Los Alamos National Laboratory; Rice, Patrick R [Los Alamos National Laboratory

2008-01-01T23:59:59.000Z

423

Stable polarization-encoded quantum key distribution in fiber  

E-Print Network (OSTI)

Polarizations of single-photon pulses have been controlled with long-term stability of more than 10 hours by using an active feedback technique for auto-compensation of unpredictable polarization scrambling in long-distance fiber. Experimental tests of long-term operations in 50, 75 and 100 km fibers demonstrated that such a single-photon polarization control supported stable polarization encoding in long-distance fibers to facilitate stable one-way fiber system for polarization-encoded quantum key distribution, providing quantum bit error rates below the absolute security threshold.

Wu, G; Li, Y; Zeng, H; Wu, Guang; Chen, Jie; Li, Yao; Zeng, Heping

2006-01-01T23:59:59.000Z

424

Renewable: A key component of our global energy future  

DOE Green Energy (OSTI)

Inclusion of renewable energy sources in national and international energy strategies is a key component of a viable global energy future. The global energy balance is going to shift radically in the near future brought about by significant increases in population in China and India, and increases in the energy intensity of developing countries. To better understand the consequences of such global shifts in energy requirements and to develop appropriate energy strategies to respond to these shifts, we need to look at the factors driving choices among supply options by geopolitical consumers and the impact these factors can have on the future energy mix.

Hartley, D.

1995-12-31T23:59:59.000Z

425

Key results from SB8 simulant flowsheet studies  

SciTech Connect

Key technically reviewed results are presented here in support of the Defense Waste Processing Facility (DWPF) acceptance of Sludge Batch 8 (SB8). This report summarizes results from simulant flowsheet studies of the DWPF Chemical Process Cell (CPC). Results include: Hydrogen generation rate for the Sludge Receipt and Adjustment Tank (SRAT) and Slurry Mix Evaporator (SME) cycles of the CPC on a 6,000 gallon basis; Volume percent of nitrous oxide, N2O, produced during the SRAT cycle; Ammonium ion concentrations recovered from the SRAT and SME off-gas; and, Dried weight percent solids (insoluble, soluble, and total) measurements and density.

Koopman, D. C.

2013-04-26T23:59:59.000Z

426

Liquid Hydrogen Target Experience at SLAC  

DOE Green Energy (OSTI)

Liquid hydrogen targets have played a vital role in the physics program at SLAC for the past 40 years. These targets have ranged from small ''beer can'' targets to the 1.5 m long E158 target that was capable of absorbing up to 800 W without any significant density changes. Successful use of these targets has required the development of thin wall designs, liquid hydrogen pumps, remote positioning and alignment systems, safety systems, control and data acquisition systems, cryogenic cooling circuits and heat exchangers. Detailed operating procedures have been created to ensure safety and operational reliability. This paper surveys the evolution of liquid hydrogen targets at SLAC and discusses advances in several of the enabling technologies that made these targets possible.

Weisend, J.G.; Boyce, R.; Candia, A.; Kaminskas, W.; Mark, J.; Racine, M.; St. Lorant, S.; Weber, T.; /SLAC; Arnold, R.; Bosted, P.; /Massachusetts U., Amherst; Carr, R.; Gao, J.; Jones, C.E.; McKeown, R.; /Caltech

2005-08-29T23:59:59.000Z

427

Key Distribution based on Three Player Quantum Games  

E-Print Network (OSTI)

We study a new QKD that is different from the scheme proposed by \\cite{Ramz2}, though it essentially takes our ground on three-player quantum games and Greenberg-Horne-Zeilinger triplet entangled state (GHZ state) \\cite{Gree} is used. In the scheme proposed in this paper, players in the game, Bob and Charlie (and Alice also) can get some common key or information (applied strategies and their payoffs in the game), when Alice informs Bob and Charlie about some results of the measurement made by her. Even if somebody else knows the public information, he/she can not get any key information. There is not any arbiter in our scheme, since existence of an arbiter increases the risk of wiretapping. Lastly we discuss robustness of the proposed QKD method for eavesdrop. We show that though maximally entangled case and non-entangled case essentially provide an equivalent way as QKD, the latter is not available in the case where there are some eavesdroppers. At the same time, we point put that the entanglement of the initial state is crucial when a partially entangled state is used.

Norihito Toyota

2010-10-09T23:59:59.000Z

428

Iron(III)-doped, silica : biodegradable, self-targeting nanoparticles  

E-Print Network (OSTI)

Mixtures Worksheet Answer Key for Solutions and MixturesSolutions and Mixtures (Answer Key) Purpose: Today you will

Mitchell, Kristina Kalani Pohaku

2011-01-01T23:59:59.000Z

429

NIST Forensics Science -- Drugs and Toxicology  

Science Conference Proceedings (OSTI)

... Sign up to receive news about NIST Forensic Science. *Email Address. ... NIST Forensic Science Drugs and Toxicology. Credit: iStock. ...

2013-09-23T23:59:59.000Z

430

Encryption Key Search using Java-based ALiCE Grid  

E-Print Network (OSTI)

Encryption Key Search is a compute-intensive operation that consists of a brute-force search of a particular key in a given key space. Sequential execution time for a 56-bit encryption key search is approximately 200,000 ...

Virkar, Ameya

431

Key Response Planning Factors for the Aftermath of Nuclear Terrorism  

Science Conference Proceedings (OSTI)

Despite hundreds of above-ground nuclear tests and data gathered from Hiroshima and Nagasaki, the effects of a ground-level, low-yield nuclear detonation in a modern urban environment are still the subject of considerable scientific debate. Extensive review of nuclear weapon effects studies and discussions with nuclear weapon effects experts from various federal agencies, national laboratories, and technical organizations have identified key issues and bounded some of the unknowns required to support response planning for a low-yield, ground-level nuclear detonation in a modern U.S. city. This study, which is focused primarily upon the hazards posed by radioactive fallout, used detailed fallout predictions from the advanced suite of three-dimensional (3-D) meteorology and plume/fallout models developed at Lawrence Livermore National Laboratory (LLNL), including extensive global Key Response Planning Factors for the Aftermath of Nuclear Terrorism geographical and real-time meteorological databases to support model calculations. This 3-D modeling system provides detailed simulations that account for complex meteorology and terrain effects. The results of initial modeling and analysis were presented to federal, state, and local working groups to obtain critical, broad-based review and feedback on strategy and messaging. This effort involved a diverse set of communities, including New York City, National Capitol Regions, Charlotte, Houston, Portland, and Los Angeles. The largest potential for reducing casualties during the post-detonation response phase comes from reducing exposure to fallout radiation. This can be accomplished through early, adequate sheltering followed by informed, delayed evacuation.B The response challenges to a nuclear detonation must be solved through multiple approaches of public education, planning, and rapid response actions. Because the successful response will require extensive coordination of a large number of organizations, supplemented by appropriate responses by local responders and the general population within the hazard zones, regional planning is essential to success. The remainder of this Executive Summary provides summary guidance for response planning in three areas: (1) Public Protection Strategy details the importance of early, adequate shelter followed by informed evacuation. (2) Responder Priorities identify how to protect response personnel, perform regional situational assessment, and support public safety. (3) Key Planning Considerations refute common myths and provide important information on planning how to respond in the aftermath of nuclear terrorism.

Buddemeier, B R; Dillon, M B

2009-01-21T23:59:59.000Z

432

Progress in chemical processing of LEU targets for {sup 99}Mo production -- 1997  

SciTech Connect

Presented here are recent experimental results of the continuing development activities associated with converting current processes for producing fission-product {sup 99}Mo from targets using high-enriched uranium (HEU) to low-enriched uranium (LEU). Studies were focused in four areas: (1) measuring the chemical behavior of iodine, rhodium, and silver in the LEU-modified Cintichem process, (2) performing experiments and calculations to assess the suitability of zinc fission barriers for LEU metal foil targets, (3) developing an actinide separations method for measuring alpha contamination of the purified {sup 99}Mo product, and (4) developing a cooperation with Sandia National Laboratories and Los Alamos National Laboratory that will lead to approval by the US Federal Drug Administration for production of {sup 99}Mo from LEU targets. Experimental results continue to show the technical feasibility of converting current HEU processes to LEU.

Vandegrift, G.F.; Conner, C.; Sedlet, J.; Wygmans, D.G. [Argonne National Lab., IL (United States); Wu, D. [Univ. of Illinois, Urbana, IL (United States); Iskander, F.; Landsberger, S. [Univ. of Texas, Austin, TX (United States)

1997-10-01T23:59:59.000Z

433

Investing in Oil and Natural Gas A Few Key Issues  

U.S. Energy Information Administration (EIA) Indexed Site

Strategic Advisors in Global Energy Strategic Advisors in Global Energy Strategic Advisors in Global Energy Strategic Advisors in Global Energy Investing in Oil and Natural Gas: A Few Key Issues Prepared for EIA Conference Susan Farrell, Senior Director PFC Energy April 8, 2009 Investing in Oil and Gas| PFC Energy| Page 2 The Top 20 IOCs and Top 20 NOCs Account for Over Half of E&P Spend Source: PFC Energy, Global E&P Surveys Investing in Oil and Gas| PFC Energy| Page 3 Oil Prices Rose, But So Did Costs + 52% $0 $20 $40 $60 $80 $100 $120 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 WTI $/barrel Annual averages Large Gulf of Mexico Facility Costs by Segment Avg $28.31 Avg $59.13 Source: PFC Energy Investing in Oil and Gas| PFC Energy| Page 4 Near term Spending Cuts will be Significant

434

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

December 9, 2009 - 12:00am December 9, 2009 - 12:00am Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Patricia A. Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, Department of Energy Mari Del Carmen Aponte, Ambassador to the Republic of El Salvador, Department of State Donald E. Booth, Ambassador to the Federal Democratic Republic of Ethiopia, Department of State Larry Persily, Federal Coordinator for Alaska Natural Gas Transportation Projects President Obama said, "The depth of experience these individuals bring to their roles will be valuable to my administration as we work to bring about real change for the American people. I look forward to working with them in

435

Nano Changes Have Macro Importance for a Key Electronics Material |  

NLE Websites -- All DOE Office Websites (Extended Search)

Squeezing an Old Material Could Yield "Instant-On" Memory Squeezing an Old Material Could Yield "Instant-On" Memory A Metal That Becomes Transparent under Pressure Under Pressure, Atoms Make Unlikely Alloys Slowing Down Near the Glass Transition New Light on Improving Engine Efficiencies Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Nano Changes Have Macro Importance for a Key Electronics Material APRIL 23, 2009 Bookmark and Share Original image courtesy of http://www.freefoto.com By combining the results from several powerful techniques for studying materials structure at the nanoscale, including work at the U.S. Department of Energy's Advanced Photon Source (APS) at Argonne National Laboratory,

436

LANL to play key role in biofuel development  

NLE Websites -- All DOE Office Websites (Extended Search)

Biofuel development Biofuel development LANL to play key role in biofuel development LANL to create a proof-of-concept system for commercializing algae-based biofuels or other advanced biofuels that can be transported and sold using the nation's existing fueling infrastructure. January 14, 2010 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

437

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

April 17, 2009 - 12:00am April 17, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Christine M. Griffin, Deputy Director of Office of Personnel Management; Kevin Concannon, Under Secretary for Food, Nutrition and Consumer Services, United States Department of Agriculture; Rajiv Shah, Under Secretary for Research, Education, and Economics, United States Department of Agriculture; Michael Nacht, Assistant Secretary of Defense (Global Strategic Affairs), Department of Defense; Mercedes Márquez, Assistant Secretary for Community Planning and Development, Department of Housing and Urban Development; Raymond M. Jefferson, Assistant Secretary for Veterans Employment and Training, Department of Labor; Robert S. Litt, General

438

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

December 10, 2010 - 12:00am December 10, 2010 - 12:00am Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Peter B. Lyons, Assistant Secretary for Nuclear Energy, Department of Energy Denise E. O'Donnell, Director of the Bureau of Justice Assistance, Department of Justice Stephanie O'Sullivan, Principal Deputy Director of National Intelligence, Directorate of National Intelligence David Shear, Ambassador to the Socialist Republic of Vietnam, Department of State The President also announced his intent to appoint Harvey S. Wineberg as a Member of the President's Advisory Council on Financial Capability. His biography is below. President Obama said, "The American people will be greatly served by the

439

Potential Benefits from Improved Energy Efficiency of Key Electrical Products:  

NLE Websites -- All DOE Office Websites (Extended Search)

8254 8254 Potential Benefits from Improved Energy Efficiency of Key Electrical Products: The Case of India Michael McNeil, Maithili Iyer, Stephen Meyers, Virginie Letschert, James E. McMahon Environmental Energy Technologies Division Lawrence Berkeley National Laboratory University of California, Berkeley Berkeley, CA December 2005 This work was supported by the International Copper Association through the U.S. Department of Energy under Contract No. DE-AC03-76SF00098. 2 ABSTRACT The goal of this project was to estimate the net benefits that cost-effective improvements in energy efficiency can bring to developing countries. The study focused on four major electrical products in the world's second largest developing country, India. These

440

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

July 8, 2009 - 12:00am July 8, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Joe Garcia, Director of the Office of Minority Economic Impact, Department of Energy Michael H. Posner, Assistant Secretary of State for Democracy, Human Rights, and Labor, Department of State Stephen J. Rapp, Ambassador at Large for War Crimes Issues, Department of State Alexander G. Garza, Assistant Secretary for Health Affairs and Chief Medical Officer, Department of Homeland Security Susan L. Kurland, Assistant Secretary for Aviation and International Affairs, Department of Transportation Kenneth A. Spearman, Member of the Board of Directors, Farm Credit Administration Rolena Adorno, Member of the National Council on the Humanities

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

City of Key West, Florida (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

Florida (Utility Company) Florida (Utility Company) Jump to: navigation, search Name Key West City of Place Florida Utility Id 10226 Utility Location Yes Ownership M NERC Location FRCC NERC FRCC Yes Operates Generating Plant Yes Activity Generation Yes Activity Transmission Yes Activity Buying Transmission Yes Activity Distribution Yes Alt Fuel Vehicle Yes Alt Fuel Vehicle2 Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Governmental Recreational Facility Lighting (Schedule S-3) LED High Watt, Approx. 72 Watt (Street Light Schedule S-1) Lighting LED High Watt, Approx. 72 Watts (Area Lighting Schedule S-2) Lighting

442

LANL breaks ground on key sediment control project  

NLE Websites -- All DOE Office Websites (Extended Search)

Sediment control project Sediment control project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately $2 million features are up to eight feet high and made of rocks packed tightly into wire enclosures. November 5, 2009 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

443

A verifiable random function with short proofs and keys  

E-Print Network (OSTI)

Abstract. We give a simple and efficient construction of a verifiable random function (VRF) on bilinear groups. Our construction is direct. In contrast to prior VRF constructions [14, 15], it avoids using an inefficient Goldreich-Levin transformation, thereby saving several factors in security. Our proofs of security are based on a decisional bilinear Diffie-Hellman inversion assumption, which seems reasonable given current state of knowledge. For small message spaces, our VRFs proofs and keys have constant size. By utilizing a collision-resistant hash function, our VRF can also be used with arbitrary message spaces. We show that our scheme can be instantiated with an elliptic group of very reasonable size. Furthermore, it can be made distributed and proactive. 1

Yevgeniy Dodis; R Yampolskiy

2005-01-01T23:59:59.000Z

444

The Seven Keys to Success in Energy Management and Conservation  

E-Print Network (OSTI)

This paper is a summary of the seven key elements of the Deere & Company Energy Management and Conservation Program. These elements have been found to be essential for the ultimate success of any company-wide energy management program. The process of initiating an energy management program is detailed. The establishment of long range goals, together with the organization and commitment to accomplish these goals are specified. The necessity of performing an energy audit is discussed, together with an explanation of the three 'types' of energy used in a manufacturing facility. The requirement of having a good 'energy ethic' among all employees is discussed in detail. The method of monitoring the program and measuring results is also discussed.

Darby, D. F.

1984-01-01T23:59:59.000Z

445

President Obama Announces More Key Administration Posts | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4, 2009 - 12:00am 4, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Daniel B. Poneman, Deputy Secretary, Department of Energy; Fred P. Hochberg, President and Chairman of the Export-Import Bank of the United States; Francisco "Frank" J. Sánchez, Under Secretary for International Trade, Department of Commerce; Miriam E. Sapiro, Deputy Trade Representative; Judith A. McHale, Under Secretary for Public Diplomacy and Public Affairs, Department of State; Philip J. "P.J." Crowley, Assistant Secretary of State for Public Affairs, Department of State; Bonnie D. Jenkins, Coordinator for Threat Reduction Programs (with the Rank of Ambassador), Department of

446

Using Key Performance Indicators to Manage Energy Costs  

E-Print Network (OSTI)

Modern management systems rely heavily on information technology to set goals, track performance and communicate results. Energy management approaches (such as those offered by the US Department of Energy and Natural Resources Canada) and measurement and verification protocols (such as IPMVP 2001) often highlight the importance an information system has in maximizing results. The increasing adoption of energy information systems has led, however, to an interesting paradox: while it is now cost-effective to collect much more data than ever before, many energy managers find themselves drowning in the volume of data generated. Business information systems faced a similar challenge a decade ago, and it is now common practice to use Key Performance Indicators (KPIs) to summarize volumes of data into a few critical nuggets of actionable information. These KPIs provide both the metrics that will be used to determine the success of a business plan as well as the timely information managers need to track performance and make adjustments to ensure success. A similar approach can be used in the practice of energy management, where KPIs can be designed to measure the success of key elements in an energy management plan and provide energy managers with the timely nuggets of information they need to ensure success. This paper describes how to define and use KPIs to track the performance and measure the success of an energy management plan. A framework is provided to assist in selecting measurable goals from an energy management plan and determine the raw data and processing required to generate the associated KPIs.

Van Gorp, J. C.

2005-01-01T23:59:59.000Z

447

Moller Polarimetry with Atomic Hydrogen Targets  

Science Conference Proceedings (OSTI)

A proposal to use polarized atomic hydrogen gas as the target for electron beam polarimetry based on the Moller scattering is described. Such a gas, stored in an ultra-cold magnetic trap, would provide a target of practically 100\\% polarized electrons. It is conceivable to reach a $\\sim$0.3\\% systematic accuracy of the beam polarimetry with such a target. Feasibility studies for the CEBAF electron beam have been performed.

Eugene Chudakov

2012-06-01T23:59:59.000Z

448

Mar. Drugs 2013, 11, 3350-3371; doi:10.3390/md11093350 marine drugs  

E-Print Network (OSTI)

Mar. Drugs 2013, 11, 3350-3371; doi:10.3390/md11093350 marine drugs ISSN 1660-3397 www% cytotoxicity was observed at the highest concentration tested (5 µg mL-1 ). However, OPEN ACCESS #12;Mar. Drugs Pinna had first been implicated in food poisoning in China in 1990 [1]. Pinnatoxin A (Pn

Recanati, Catherine

449

ALT-3 target design and simulations  

SciTech Connect

ALT-3 is an experiment being designed in collaboration between Russian VNIIEF scientists and LANL that aims to conduct high velocity material experiments to measure shock velocities and pressures near 1 TPa. The DEMG (Disck Explosive Magnetic Generator) is used to drive> 60MA currents to accelerate an aluminum liner to speeds in excess of 20 km/s. 1-D and 2-D simulations of the aluminum target are presented with information on the free surface velocity profile, the state of the target, and the shock velocity in the target. 2-D simulations are presented showing the different targets available as well as a scenario with a perturbed liner impacter.

Peterson, Jeffrey H [Los Alamos National Laboratory

2011-01-12T23:59:59.000Z

450

The Target Market for Methanol Fuel  

E-Print Network (OSTI)

be to place a surcharge on dirtier fuels (e.g. gasoline) assurcharge was specifically targeted to supporting cleaner fuels and

Sperling, Daniel; Setiawan, Winardi; Hungerford, David

1995-01-01T23:59:59.000Z

451

S&TR | Meeting the Target Challenge  

NLE Websites -- All DOE Office Websites (Extended Search)

with a cryogenic layering and characterization station and a target positioner. Scanning electron microscope images of polystyrene beads in copper foams. Scanning electron...

452

Project Plan Remote Target Fabrication Refurbishment Project  

Science Conference Proceedings (OSTI)

In early FY2009, the DOE Office of Science - Nuclear Physics Program reinstated a program for continued production of {sup 252}Cf and other transcurium isotopes at the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). The FY2009 major elements of the workscope are as follows: (1) Recovery and processing of seven transuranium element targets undergoing irradiation at the High Flux Isotope Reactor (HFIR) at ORNL; (2) Development of a plan to manufacture new targets for irradiation beginning in early- to mid-FY10 to supply irradiated targets for processing Campaign 75 (TRU75); and (3) Refurbishment of the target manufacturing equipment to allow new target manufacture in early FY10 The {sup 252}Cf product from processing Campaign 74 (recently processed and currently shipping to customers) is expected to supply the domestic demands for a period of approximately two years. Therefore it is essential that new targets be introduced for irradiation by the second quarter of FY10 (HFIR cycle 427) to maintain supply of {sup 252}Cf; the average irradiation period is {approx}10 HFIR cycles, requiring about 1.5 calendar years. The strategy for continued production of {sup 252}Cf depends upon repairing and refurbishing the existing pellet and target fabrication equipment for one additional target production campaign. This equipment dates from the mid-1960s to the late 1980s, and during the last target fabrication campaign in 2005- 2006, a number of component failures and operations difficulties were encountered. It is expected that following the target fabrication and acceptance testing of the targets that will supply material for processing Campaign 75 a comprehensive upgrade and replacement of the remote hot-cell equipment will be required prior to subsequent campaigns. Such a major refit could start in early FY 2011 and would take about 2 years to complete. Scope and cost estimates for the repairs described herein were developed, and authorization for the work was received in July 2009 under the Remote Target Fabrication Refurbishment Task of the Enhanced Utilization of Isotope Facilities project (Project Identification Code 2005230) funded by the American Recovery and Reinvestment Act of 2009. The goal of this project is to recover the capability to produce 4-5 curium targets for the irradiation period starting with HFIR cycle 427, currently scheduled to begin 2/17/10. Assuming success, the equipment would then be used to fabricate 6-7 additional targets to hold for the next irradiation campaign specified by the program. Specific objectives are the return to functionality of the Cubicle 3 Pellet Fabrication Line; Cubicle 2 Target Assembly equipment; and Cubicle 1 Target Inspection and Final Assembly system.

Bell, Gary L [ORNL; Taylor, Robin D [ORNL

2009-08-01T23:59:59.000Z

453

Chemical Innovation in Drug Dr Matthew Fuchter  

E-Print Network (OSTI)

Chemical Innovation in Drug Discovery Dr Matthew Fuchter Lecturer in Synthetic and Medicinal&D Spending and Output #12;Chemical Innovation Impact Discovery Development Basic research: years 0-3 Pre 3, File DRUG Chemical start point Hit to lead Preclinical Assessment Synthetic Chemistry Chemistry

454

Thermal-hydraulic analysis of the LANL/IPPE/EDO-GP 1-MW LBE target  

SciTech Connect

The accelerator-driven transmutation of waste (ATW) concept has been proposed by the United States and other countries to transmute plutonium, higher actinides, and other environmentally hazardous fission products. One of the key components in the ATW concept is a target that, via spallation, produces neutrons to transmute nuclear waste. Since significant heat is generated during fissioning of the waste actinides, an efficient heat removal system is necessary. Liquid lead-bismuth eutectic (LBE) is an efficient coolant as well as a good spallation target for production of neutrons. The LBE coolant technology has been successfully used in Russian submarine nuclear reactors. The International Science and Technology Center (ISTC) has funded the Institute of Physics and Power Engineering (IPPE) and the Experiment and Design Organization-Gidropress (EDO-GP) of Russia to design and manufacture a pilot target (Target Circuit One-TC1) that incorporates Russian LBE technology into the ATW concept. The target will be tested in the 800-MeV, 1-mA proton beam at the Los Alamos National Laboratory (LANL) in 2 yr. These target experiments will provide valuable information on the performance of LBE as both spallation target and coolant. They will also help to design target/blanket systems for future ATW facilities. In summary, the authors have carried out thermal-hydraulic analyses for the LANL/IPPE/EDO-GP 1-MW LBE target. It is shown that the current design is suitable for the beam-on tests. The diffuser plate successfully enhances the coolant flow around the window center but still avoids generating recirculation zone downstream. The temperature range is within the proper operation range for both the LBE coolant and the structural materials.

He, X.; Ammerman, C.; Woloshun, K.; Li, N.

2000-07-01T23:59:59.000Z

455

Multimodality Imaging with Silica-Based Targeted Nanoparticle Platforms  

SciTech Connect

Objectives: To synthesize and characterize a C-Dot silica-based nanoparticle containing 'clickable' groups for the subsequent attachment of targeting moieties (e.g., peptides) and multiple contrast agents (e.g., radionuclides with high specific activity) [1,2]. These new constructs will be tested in suitable tumor models in vitro and in vivo to ensure maintenance of target-specificity and high specific activity. Methods: Cy5 dye molecules are cross-linked to a silica precursor which is reacted to form a dye-rich core particle. This core is then encapsulated in a layer of pure silica to create the core-shell C-Dot (Figure 1) [2]. A 'click' chemistry approach has been used to functionalize the silica shell with radionuclides conferring high contrast and specific activity (e.g. 64Cu and 89Zr) and peptides for tumor targeting (e.g. cRGD and octreotate) [3]. Based on the selective Diels-Alder reaction between tetrazine and norbornene, the reaction is bioorthogonal, highyielding, rapid, and water-compatible. This radiolabeling approach has already been employed successfully with both short peptides (e.g. octreotate) and antibodies (e.g. trastuzumab) as model systems for the ultimate labeling of the nanoparticles [1]. Results: PEGylated C-Dots with a Cy5 core and labeled with tetrazine have been synthesized (d = 55 nm, zeta potential = -3 mV) reliably and reproducibly and have been shown to be stable under physiological conditions for up to 1 month. Characterization of the nanoparticles revealed that the immobilized Cy5 dye within the C-Dots exhibited fluorescence intensities over twice that of the fluorophore alone. The nanoparticles were successfully radiolabeled with Cu-64. Efforts toward the conjugation of targeting peptides (e.g. cRGD) are underway. In vitro stability, specificity, and uptake studies as well as in vivo imaging and biodistribution investigations will be presented. Conclusions: C-Dot silica-based nanoparticles offer a robust, versatile, and multi-functional platform to enhance in vivo detection sensitivity and non-invasively assay receptor expression/status of tumor cellular targets, including those of low abundance, using nuclear-NIR fluorescence imaging approaches [2]. Improvements in molecular diagnostics, refined by the availability of nanotechnology platforms, will be a key determinant in driving early-stage disease detection and prevention, ultimately leading to decreases in mortality.

Jason S. Lewis

2012-04-09T23:59:59.000Z

456

Moller Polarimetry with Atomic Hydrogen Targets  

DOE Green Energy (OSTI)

A novel proposal of using polarized atomic hydrogen gas, stored in an ultra-cold magnetic trap, as the target for electron beam polarimetry based on Moller scattering is discussed. Such a target of practically 100% polarized electrons could provide a superb systematic accuracy of about 0.5% for beam polarization measurements. The feasibility studies for the CEBAF electron beam have been performed.

Eugene Chudakov; Vladimir Luppov

2003-10-19T23:59:59.000Z

457

Polarized hydrogen gas target. Closeout report  

DOE Green Energy (OSTI)

The purpose of the equipment was to produce a polarized gas target for use as an internal target in storage rings. The part funded under this grant was the construction of the atomic-beam apparatus. In addition to the $300,000 award, $13,267 from DOE operating funds and $19,700 provided by the University was spent on the construction of the atomic beam apparatus. Certain other parts required for the experiments, like the target cell, the target vacuum chamber, and the detectors, were funded by the University of Wisconsin. The cost for installation of the target in the cooler ring at the Indiana University Cyclotron Facility was $2,400. The equipment became operational for the first time in August 1992, after the sixpole magnets, the delivery of which was delayed by more than 6 months because of manufacturing problems, were delivered. There followed a period of measurements to optimize the atomic-beam intensity. In 1992, further work was done using other sources of funds to augment the performance of the polarized gas target by means of radiofrequency (RF) transitions intended to double the degree of polarization of the target. Immediately after the above tests, the polarized gas target equipment was shipped to Bloomington, Indiana where installation in the proton storage ring was completed in July 1993.

NONE

1994-12-31T23:59:59.000Z

458

Optimal Adaptive Waveform Selection for Target Tracking  

E-Print Network (OSTI)

Optimal Adaptive Waveform Selection for Target Tracking Barbara La Scala Mohammad Rezaeian Bill algorithms. This paper describes an optimal adaptive waveform selection algorithm for target tracking. An adap- tive scheduling algorithm that selects the waveforms to be used in future epochs based on current

Rezaeian, Mohammad-Jafar

459

Target assistance for subtly balancing competitive play  

Science Conference Proceedings (OSTI)

In games where skills such as targeting are critical to winning, it is difficult for players with different skill levels to have a competitive and engaging experience. Although several mechanisms for accommodating different skill levels have been proposed, ... Keywords: competition, game balance, game design, target assistance

Scott Bateman; Regan L. Mandryk; Tadeusz Stach; Carl Gutwin

2011-05-01T23:59:59.000Z

460

Liner target interaction experiments on Pegasus II  

SciTech Connect

The Los Alamos High Energy Density Physics program uses capacitively driven low voltage, inductive-storage pulse power to implode cylindrical targets for hydrodynamics experiments. Once a precision driver liner was characterized an experimental series characterizing the aluminum target dynamics was performed. The target was developed for shock-induced quasi-particle ejecta experiments including holography. The concept for the Liner shock experiment is that the driver liner is used to impact the target liner which then accelerates toward a collimator with a slit in it. A shock wave is set up in the target liner and as the shock emerges from the back side of the target liner, ejecta are generated. By taking a laser hologram the particle distribution of the ejecta are hoped to be determined. The goal for the second experimental series was to characterize the target dynamics and not to measure and generate the ejecta. Only the results from the third shot, Pegasus II-26 fired April 26th, 1994, from the series is discussed in detail. The second experimental series successfully characterized the target dynamics necessary to move forward towards the planned quasi-ejecta experiments.

Hockaday, M.P.; Chrien, R.E.; Bartsch, R. [and others

1995-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Computer vision aided target linked radiation imaging  

Science Conference Proceedings (OSTI)

In this paper, we demonstrated an application of video tracking to radiation detection, where a vision-based tracking system enables a traditional CZT (cadmium zinc telluride)-based radiation imaging device to detect radioactive targets that are in motion. ... Keywords: Vehicles,Target tracking,Detectors,Radiation imaging,Cameras,Streaming media

Yi Yao

2012-06-01T23:59:59.000Z

462

Polarized proton target-IV. Operations manual  

SciTech Connect

Standard operating procedures are presented for the vacuum, cryogenic, and electronic systems of a polarized proton target. The systems are comprised of (1) a target cryostat; (2) a $sup 4$He pumping system; (3) a $sup 3$He pumping system; (4) a microwave system; (5) a magnet and power supply; (6) a computerized polarization monitor; and (7) miscellaneous auxiliary equipment. (PMA)

Hill, D.; Fletcher, O.; Moretti, A.; Onesto, F.

1976-01-01T23:59:59.000Z

463

Setting targets for surrogate-based optimization  

Science Conference Proceedings (OSTI)

In the context of surrogate-based optimization (SBO), most designers have still very little guidance on when to stop and how to use infill measures with target requirements (e.g., one-stage approach for goal seeking and optimization); the reason: optimum ... Keywords: Extreme value theory, Minimum estimates from sample data, Setting targets, Surrogate-based optimization

Nestor V. Queipo; Salvador Pintos; Efrain Nava

2013-04-01T23:59:59.000Z

464

Do myoepithelial cells hold the key for breast tumorprogression?  

SciTech Connect

Mammary myoepithelial cells have been the foster child of breast cancer biology and have been largely ignored since they were considered to be less important for tumorigenesis than luminal epithelial cells from which most of breast carcinomas are thought to arise. In recent years as our knowledge in stem cell biology and the cellular microenvironment has been increasing myoepithelial cells are slowly starting to gain more attention. Emerging data raise the hypothesis if myoepithelial cells play a key role in breast tumor progression by regulating the in situ to invasive carcinoma transition and if myoepithelial cells are part of the mammary stem cell niche. Paracrine interactions between myoepithelial and luminal epithelial cells are known to be important for cell cycle arrest, establishing epithelial cell polarity, and inhibiting migration and invasion. Based on these functions normal mammary myoepithelial cells have been called ''natural tumor suppressors''. However, during tumor progression myoepithelial cells seem to loose these properties and eventually they themselves diminish as tumors become invasive. Better understanding of myoepithelial cell function and their role in tumor progression may lead to their exploitation for cancer therapeutic and preventative measures.

Polyak, Kornelia; Hu, Min

2005-11-18T23:59:59.000Z

465

Optimising waste management performance - The key to successful decommissioning  

SciTech Connect

Available in abstract form only. Full text of publication follows: On the 1. of April 2005 the United Kingdom's Nuclear Decommissioning Authority became responsible for the enormous task of decommissioning the UK's civilian nuclear liabilities. The success of the NDA in delivering its key objectives of safer, cheaper and faster decommissioning depends on a wide range factors. It is self-evident, however, that the development of robust waste management practices by those charged with decommissioning liability will be at the heart of the NDA's business. In addition, the implementation of rigorous waste minimisation techniques throughout decommissioning will deliver tangible environmental benefits as well as better value for money and release funds to accelerate the decommissioning program. There are mixed views as to whether waste minimisation can be achieved during decommissioning. There are those that argue that the radioactive inventory already exists, that the amount of radioactivity cannot be minimised and that the focus of activities should be focused on waste management rather than waste minimisation. Others argue that the management and decommissioning of the UK's civilian nuclear liability will generate significant volumes of additional radioactive waste and it is in this area where the opportunities for waste minimisation can be realised. (author)

Keep, Matthew [Entec UK Limited. 17 Angel Gate. City Road. London EC1V 2SH (United Kingdom)

2007-07-01T23:59:59.000Z

466

Multi-client quantum key distribution using wavelength division multiplexing  

Science Conference Proceedings (OSTI)

Quantum Key Distribution (QKD) exploits the rules of quantum mechanics to generate and securely distribute a random sequence of bits to two spatially separated clients. Typically a QKD system can support only a single pair of clients at a time, and so a separate quantum link is required for every pair of users. We overcome this limitation with the design and characterization of a multi-client entangled-photon QKD system with the capacity for up to 100 clients simultaneously. The time-bin entangled QKD system includes a broadband down-conversion source with two unique features that enable the multi-user capability. First, the photons are emitted across a very large portion of the telecom spectrum. Second, and more importantly, the photons are strongly correlated in their energy degree of freedom. Using standard wavelength division multiplexing (WDM) hardware, the photons can be routed to different parties on a quantum communication network, while the strong spectral correlations ensure that each client is linked only to the client receiving the conjugate wavelength. In this way, a single down-conversion source can support dozens of channels simultaneously--and to the extent that the WDM hardware can send different spectral channels to different clients, the system can support multiple client pairings. We will describe the design and characterization of the down-conversion source, as well as the client stations, which must be tunable across the emission spectrum.

Grice, Warren P [ORNL; Bennink, Ryan S [ORNL; Earl, Dennis Duncan [ORNL; Evans, Philip G [ORNL; Humble, Travis S [ORNL; Pooser, Raphael C [ORNL; Schaake, Jason [ORNL; Williams, Brian P [ORNL

2011-01-01T23:59:59.000Z

467

Feasibility of 300 km Quantum Key Distribution with Entangled States  

E-Print Network (OSTI)

A significant limitation of practical quantum key distribution (QKD) setups is currently their limited operational range. It has recently been emphasized (X. Ma, C.-H. F. Fung, and H.-K. Lo., Phys. Rev. A, 76:012307, 2007) that entanglement-based QKD systems can tolerate higher channel losses than systems based on weak coherent laser pulses (WCP), in particular when the source is located symmetrically between the two communicating parties, Alice and Bob. In the work presented here, we experimentally study this important advantage by implementing different entanglement-based QKD setups on a 144~km free-space link between the two Canary Islands of La Palma and Tenerife. We established three different configurations where the entangled photon source was placed at Alice's location, asymmetrically between Alice and Bob and symmetrically in the middle between Alice and Bob, respectively. The resulting quantum channel attenuations of 35~dB, 58~dB and 71~dB, respectively, significantly exceed the limit for WCP systems. This confirms that QKD over distances of 300~km and even more is feasible with entangled state sources placed in the middle between Alice and Bob.

Thomas Scheidl; Rupert Ursin; Alessandro Fedrizzi; Sven Ramelow; Xiao-Song Ma; Thomas Herbst; Robert Prevedel; Lothar Ratschbacher; Johannes Kofler; Thomas Jennewein; Anton Zeilinger

2010-07-27T23:59:59.000Z

468

Do myoepithelial cells hold the key for breast tumorprogression?  

SciTech Connect

Mammary myoepithelial cells have been the foster child of breast cancer biology and have been largely ignored since they were considered to be less important for tumorigenesis than luminal epithelial cells from which most of breast carcinomas are thought to arise. In recent years as our knowledge in stem cell biology and the cellular microenvironment has been increasing myoepithelial cells are slowly starting to gain more attention. Emerging data raise the hypothesis if myoepithelial cells play a key role in breast tumor progression by regulating the in situ to invasive carcinoma transition and if myoepithelial cells are part of the mammary stem cell niche. Paracrine interactions between myoepithelial and luminal epithelial cells are known to be important for cell cycle arrest, establishing epithelial cell polarity, and inhibiting migration and invasion. Based on these functions normal mammary myoepithelial cells have been called ''natural tumor suppressors''. However, during tumor progression myoepithelial cells seem to loose these properties and eventually they themselves diminish as tumors become invasive. Better understanding of myoepithelial cell function and their role in tumor progression may lead to their exploitation for cancer therapeutic and preventative measures.

Polyak, Kornelia; Hu, Min

2005-11-18T23:59:59.000Z

469

ENVIRONMENTAL MANAGEMENT SYSTEM OBJECTIVES AND TARGETS  

NLE Websites -- All DOE Office Websites (Extended Search)

Objectives & Targets Rev. 7/17/13 Objectives & Targets Rev. 7/17/13 ENVIRONMENTAL MANAGEMENT SYSTEM OBJECTIVES AND TARGETS 2012 PROGRESS REPORT for SOUTHWESTERN POWER ADMINISTRATION Activity Legal Requirement Aspect Objective Target** see important note Target Achieved Details Real Estate Management DOE O 436.1 E.O. 13423 & 13514 EPAct 1992 and 2005 EISA 2007 NECPA 1978 Natural resource depletion and GHG emissions from resource intensive facilities Increase sustainability of facility resources, reduce energy and water consumption, reduce impacts to natural resources from facility usage 1) Meter 90% of electricity by September 2012 2) Meter 90% of gas, steam, and water by September 2015 3) 30% energy intensity reduction by 2015 from baseline 2003 4) Reduce water consumption intensity 2%

470

You Are A Target | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

You Are A Target You Are A Target You Are A Target November 6, 2013 1:00PM EST Course Title: You Are A Target Course Start/End Date: November 6, 2013 Start/End Time: 1:00 pm - 2:00 pm Course Type: Classrooom. The Meet-Me-Conference number for presentations on 11/6/2013 is 301-903-0117, reservation #447671. Both presentations on 11/6/2013 will be available via VTC. The Germantown room # is B-025. Please contact HQ DOE VTC at vtc@doe.gov or call 301-903-4555 to add your site to the bridge (i.e., 4600). Course Location: Forrestal Large Auditorium Course Description: "You Are A Target" presentation by Lance Spitzner, Training Director, SANS Securing the Human Program. Every October and November, the Department of Energy (DOE) joins the Department of Homeland Security (DHS) and other federal, state and local agencies across the

471

The Jefferson Lab Frozen Spin Target  

SciTech Connect

A frozen spin polarized target, constructed at Jefferson Lab for use inside a large acceptance spectrometer, is described. The target has been utilized for photoproduction measurements with polarized tagged photons of both longitudinal and circular polarization. Protons in TEMPO-doped butanol were dynamically polarized to approximately 90% outside the spectrometer at 5 T and 200-300 mK. Photoproduction data were acquired with the target inside the spectrometer at a frozen-spin temperature of approximately 30 mK with the polarization maintained by a thin, superconducting coil installed inside the target cryostat. A 0.56 T solenoid was used for longitudinal target polarization and a 0.50 T dipole for transverse polarization. Spin relaxation times as high as 4000 hours were observed. We also report polarization results for deuterated propanediol doped with the trityl radical OX063.

Christopher Keith, James Brock, Christopher Carlin, Sara Comer, David Kashy, Josephine McAndrew, David Meekins, Eugene Pasyuk, Joshua Pierce, Mikell Seely

2012-08-01T23:59:59.000Z

472

Target Dependent Score Normalization Techniques and . . .  

E-Print Network (OSTI)

Score normalization methods in biometric verification, which encompass the more traditional user-dependent decision thresholding techniques, are reviewed from a test hypotheses point of view. These are classified into test dependent and target dependent methods. The focus of the paper is on target dependent methods, which are further classified into impostor-centric, target-centric and target-impostor. These are applied to an on-line signature verification system on signature data from SVC 2004. In particular, a target-centric technique based on a variant of the cross-validation procedure provides the best relative performance improvement both for skilled (19%) and random forgeries (53%) as compared to the raw verification performance without score normalization (7.14% EER and 1.06% EER for skilled and random forgeries respectively).

J. Fierrez-Aguilar; J. Ortega-Garcia; J. Gonzalez-Rodriguez

2005-01-01T23:59:59.000Z

473

Multishell inertial-confinement-fusion target  

DOE Patents (OSTI)

This disclosure relates to fusion targets. It deals particularly with the production of multishell inertial confinement fusion targets. The fuel pellet within such targets is designed to compress isentropically under laser or particle irradiation. When a short pulse at extremely high power density strikes the target containing deuterium-tritium fuel, the resulting plasma is confined briefly by its own inertia. Thermonuclear energy can be released in less time than it takes the fuel pellet to blow apart. However, efficient thermonuclear burn requires that the plasma must remain intact at extremely high temperatures and densities for a time sufficient to allow a large fraction of the nuclei to react. Development of multishell targets has been directed at this problem.

Holland, J.R.; Del Vecchio, R.M.

1981-06-01T23:59:59.000Z

474

DOE Targets Rural Indiana Geologic Formation for CO2 Storage Field Test |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DOE Targets Rural Indiana Geologic Formation for CO2 Storage Field DOE Targets Rural Indiana Geologic Formation for CO2 Storage Field Test DOE Targets Rural Indiana Geologic Formation for CO2 Storage Field Test November 12, 2009 - 12:00pm Addthis Washington, DC - A U.S. Department of Energy (DOE) team of regional partners has begun injecting 8,000 tons of carbon dioxide (CO2) to evaluate the carbon storage potential and test the enhanced oil recovery (EOR) potential of the Mississippian-aged Clore Formation in Posey County, Ind. Carbon capture and storage (CCS) is seen as a key technology for reducing greenhouse gas emissions and helping to mitigate climate change. The injection, which is expected to last 6-8 months, is an integral step in DOE's Regional Carbon Sequestration Partnership program. The Midwest Geological Sequestration Consortium (MGSC) is conducting the field test to

475

Target selection for the SUNS and DEBRIS surveys for debris discs in the solar neighbourhood  

E-Print Network (OSTI)

Debris discs - analogous to the Asteroid and Kuiper-Edgeworth belts in the Solar system - have so far mostly been identified and studied in thermal emission shortward of 100 um. The Herschel space observatory and the SCUBA-2 camera on the James Clerk Maxwell Telescope will allow efficient photometric surveying at 70 to 850 um, which allow for the detection of cooler discs not yet discovered, and the measurement of disc masses and temperatures when combined with shorter wavelength photometry. The SCUBA-2 Unbiased Nearby Stars (SUNS) survey and the DEBRIS Herschel Open Time Key Project are complimentary legacy surveys observing samples of ~500 nearby stellar systems. To maximise the legacy value of these surveys, great care has gone into the target selection process. This paper describes the target selection process and presents the target lists of these two surveys.

Phillips, N M; Dent, W R F; Matthews, B C; Holland, W S; Wyatt, M C; Sibthorpe, B

2009-01-01T23:59:59.000Z

476

Final report on the Magnetized Target Fusion Collaboration  

SciTech Connect

Nuclear fusion has the potential to satisfy the prodigious power that the world will demand in the future, but it has yet to be harnessed as a practical energy source. The entry of fusion as a viable, competitive source of power has been stymied by the challenge of finding an economical way to provide for the confinement and heating of the plasma fuel. It is the contention here that a simpler path to fusion can be achieved by creating fusion conditions in a different regime at small scale (~ a few cm). One such program now under study, referred to as Magnetized Target Fusion (MTF), is directed at obtaining fusion in this high energy density regime by rapidly compressing a compact toroidal plasmoid commonly referred to as a Field Reversed Configuration (FRC). To make fusion practical at this smaller scale, an efficient method for compressing the FRC to fusion gain conditions is required. In one variant of MTF a conducting metal shell is imploded electrically. This radially compresses and heats the FRC plasmoid to fusion conditions. The closed magnetic field in the target plasmoid suppresses the thermal transport to the confining shell, thus lowering the imploding power needed to compress the target. The undertaking described in this report was to provide a suitable target FRC, as well as a simple and robust method for inserting and stopping the FRC within the imploding liner. The FRC must also survive during the time it takes for the metal liner to compress the FRC target. The initial work at the UW was focused on developing adequate preionization and flux trapping that were found to be essential in past experiments for obtaining the density, flux and most critically, FRC lifetime required for MTF. The timescale for testing and development of such a source can be rapidly accelerated by taking advantage of a new facility funded by the Department of Energy. At this facility, two inductive plasma accelerators (IPA) were constructed and tested. Recent experiments with these IPAs have demonstrated the ability to rapidly form, accelerate and merge two hypervelocity FRCs into a compression chamber. The resultant FRC that was formed was hot (T{sub ion} ~ 400 eV), stationary, and stable with a configuration lifetime several times that necessary for the MTF liner experiments. The accelerator length was less than 1 meter, and the time from the initiation of formation to the establishment of the final equilibrium was less than 10 microseconds. With some modification, each accelerator can be made capable of producing FRCs suitable for the production of the target plasma for the MTF liner experiment. Based on the initial FRC merging/compression results, the design and methodology for an experimental realization of the target plasma for the MTF liner experiment can now be defined. The construction and testing of the key components for the formation of the target plasma at the Air force Research Laboratory (AFRL) will be performed on the IPA experiment, now at MSNW. A high density FRC plasmoid will be formed and accelerated out of each IPA into a merging/compression chamber similar to the imploding liner at AFRL. The properties of the resultant FRC plasma (size, temperature, density, flux, lifetime) will be obtained. The process will be optimized, and a final design for implementation at AFRL will be carried out. When implemented at AFRL it is anticipated that the colliding/merging FRCs will then be compressed by the liner. In this manner it is hoped that ultimately a plasma with ion temperatures reaching the 10 keV range and fusion gain near unity can be obtained.

John Slough

2012-04-18T23:59:59.000Z

477

Moving Target Detection and Tracking in FLIR Image Sequences Based on Thermal Target Modeling  

Science Conference Proceedings (OSTI)

Moving target detection and tracking is an important research field of video processing for its great potential in Military and Civil applications. Motion compensation, motion detection and target tracking are the three fundamental parts of such applications; ... Keywords: FLIR, Maneuver Target, STIP, OTSU

Jiping Xu; Ikram-ul-haq; Jie Chen; Lihua Dou; Zaiwen Liu

2010-03-01T23:59:59.000Z

478

Center Update: Chemicals, Petroleum, and Natural Gas Target: A Quarterly Progress Report to Target Members  

Science Conference Proceedings (OSTI)

This document provides the "work-in-progress" on all activities under the Chemicals, Petroleum, & Natural Gas Target. It is intended to keep the members of the Target informed of all activities being conducted under this Target. The CPNG Center is a contracted office in Houston that maintains the progress on the projects cited in this document.

1999-12-17T23:59:59.000Z

479

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network (OSTI)

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

480

An implantable device for localized drug delivery and sensing  

E-Print Network (OSTI)

There are many potential clinical applications for localized drug delivery and sensing systems, such as cancer, vaccinations, pain management, and hormone therapy. Localized drug delivery systems reduce the amount of drug ...

Daniel, Karen D

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Sensitive radioenzymatic assay for catechol drugs  

Science Conference Proceedings (OSTI)

This assay measures picogram quantities of catechol drugs and endogenous catecholamines in body tissues and fluids. The catechols are converted to their 3H-O-methyl metabolites during incubation with 3H-S-adenosylmethionine then separated by solvent extraction and thin-layer chromatography. Most drugs containing the catechol structure can be radiolabeled and separated from norepinephrine and epinephrine by this technique to provide simultaneous measurement of endogenous and exogenously administered catechols. The disposition of isoproterenol in tissues and fluids of man and experimental animals is measured to illustrate the utility of this assay. The reactivity of several commonly administered catechol drugs with COMT is described and the possible implications discussed.

Durrett, L.R.; Ziegler, M.G.

1980-01-01T23:59:59.000Z

482

Provably-Secure two-round password-authenticated group key exchange in the standard model  

Science Conference Proceedings (OSTI)

Password-authenticated group key exchange (PAGKE) allows group users to share a session key using a human-memorable password only. The fundamental security goal of PAGKE is security against dictionary attacks. Several solutions have been proposed ...

Jeong Ok Kwon; Ik Rae Jeong; Dong Hoon Lee

2006-10-01T23:59:59.000Z

483

High-Rate Quantum Key Distribution with Superconducting Nanowire Single Photon Detectors  

E-Print Network (OSTI)

We demonstrate the potential for 1.85 Mbit/s secure key rates over 101 km of fiber, >100 times faster than previously demonstrated, using the differential phase shift quantum key distribution protocol and superconducting ...

Spellmeyer, Neal W.

484

A hybrid data structure for dense keys in in-memory database systems  

E-Print Network (OSTI)

This thesis presents a data structure which performs well for in-memory indexing of keys that are unevenly distributed into clusters with a high density of keys. This pattern is prevalent, for example, in systems that use ...

Muiz Navarro, Jos Alberto

2010-01-01T23:59:59.000Z

485

Direct and Reverse Secret-Key Capacities of a Quantum Channel  

E-Print Network (OSTI)

We define the direct and reverse secret-key capacities of a memoryless quantum channel as the optimal rates that entanglement-based quantum-key-distribution protocols can reach by using a single forward classical communication ...

Braunstein, Samuel L.

486

NERSC Global Filesystem Played a Key Role in Discovery of the...  

NLE Websites -- All DOE Office Websites (Extended Search)

NGFS Played a Key Role in Neutrino Finding NERSC Global Filesystem Played a Key Role in Discovery of the Last Neutrino Mixing Angle February 7, 2013 | Tags: High Energy Physics...

487

In Utero Drug Exposure Detection by Meconium Analysis  

Science Conference Proceedings (OSTI)

... 5-MeO-DiPT Pharmacokinetics Meyer & Maurer Current Drug Metabolism 2010 ... Jang, PhD China Brazil Brazil ... Emerging Trends in Designer Drugs

2013-04-30T23:59:59.000Z

488

Time-cost analysis of a quantum key distribution system clocked at 100 MHz  

E-Print Network (OSTI)

We describe the realization of a quantum key distribution (QKD) system clocked at 100 MHz. The system includes classical postprocessing implemented via software, and is operated over a 12 km standard telecommunication dark fiber in a real-world environment. A time-cost analysis of the sifted, error-corrected, and secret key rates relative to the raw key rate is presented, and the scalability of our implementation with respect to higher secret key rates is discussed.

Xiaofan Mo; Itzel Lucio Martinez; Philip Chan; Chris Healey; Steve Hosier; Wolfgang Tittel

2011-05-18T23:59:59.000Z

489

SNS target reaches end-of-life  

Science Conference Proceedings (OSTI)

On Sunday, April 3, 2011, the Spallation Neutron Source (SNS) target reached an end-of-life condition, so user operations were shut down to change the stainless steel target housing the liquid mercury. This is the third change out of the target vessel; it is an expected event and took about two weeks. We took advantage of this time to do maintenance work that was planned for the longer summer shutdown. This will shorten that shutdown and recover the neutron production time. SNS restarted user operations on April 20.

Ekkebus, Allen E [ORNL

2011-01-01T23:59:59.000Z

490

Intradermal needle-free powdered drug injection  

E-Print Network (OSTI)

This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

Liu, John (John Hsiao-Yung)

2012-01-01T23:59:59.000Z

491

Animal Reactions to Chemicals/Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

in dogs. Other drugs like Tylenol, while safe in humans can also be toxic in dogs and cats. Even vegetables like onions can be toxic to cats and dogs. Many other examples exist,...

492

The globalization of clinical drug development  

E-Print Network (OSTI)

Industry-sponsored clinical research of investigational drugs (also called clinical development) has traditionally been carried out in relatively developed countries in the North American, Western European, and Pacific ...

Thiers, Fabio Albuquerque

2006-01-01T23:59:59.000Z

493

Essays on Drug Use and Crime  

E-Print Network (OSTI)

initiation to drugs and crime in Britain. Economic Journal,to avoid being convicted of a crime that is in the strikethe courts, prisons, and crime in California and Washington

Deza, Monica

2012-01-01T23:59:59.000Z

494

Computational model of local intravascular drug delivery  

E-Print Network (OSTI)

Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

Balakrishnan, Brinda

2007-01-01T23:59:59.000Z

495

Chapter 2 Suggested Problems: Final Answer Key Atomic mass: mass of an individual atom  

E-Print Network (OSTI)

Chapter 2 Suggested Problems: Final Answer Key 2.1 Atomic mass: mass of an individual atom Atomic;Chapter 3 Suggested Problems: Final Answer Key 3.1 Atomic Structure: relates the # of protons and neutrons of intercepts 2 2 1 Reduction not necessary Enclosure (221) #12;Chapter 12 Suggested Problems: Final Answer Key

Grunlan, Melissa A.

496

Improvement on Pretty-Simple Password Authenticated Key-Exchange Protocol for Wireless Networks  

Science Conference Proceedings (OSTI)

This paper presents an improved method inspired by the recently proposed Pretty-Simple PAKE (Password Authenticated Key-Exchange) protocol, which is already a well-known, robust and simple password authenticated key exchange scheme. In our even more ... Keywords: elliptic curve discrete logarithm, key exchange, password authentication, wireless network

Ting-Yi Chang; Chou-Chen Yang; Chia-Meng Chen

2004-04-01T23:59:59.000Z

497

Low Complexity Spatio-Temporal Key Frame Encoding for Wyner-Ziv Video Coding  

Science Conference Proceedings (OSTI)

In most Wyner-Ziv video coding approaches, the temporal correlation of key frames is not exploited since they are simply intra encoded and decoded. In this paper, using the previously decoded key frame as the side information for the key frame to be ... Keywords: Wyner-Ziv coding, Distributed video coding

Ghazaleh Esmaili; Pamela Cosman

2009-03-01T23:59:59.000Z

498

KALwEN: a new practical and interoperable key management scheme for body sensor networks  

Science Conference Proceedings (OSTI)

Key management is the pillar of a security architecture. Body sensor networks (BSNs) pose several challengessome inherited from wireless sensor networks (WSNs), some unique to themselvesthat require a new key management scheme to be tailor-made. ... Keywords: body area networks, body sensor networks, healthcare, key management, security

Yee Wei Law; Giorgi Moniava; Zheng Gong; Pieter Hartel; Marimuthu Palaniswami

2011-11-01T23:59:59.000Z

499

The Fate of MAb targeted Cd125mTe/ZnS nanoparaticles in vivo  

Science Conference Proceedings (OSTI)

Nanoparticles (NP) have potential as carriers for drugs and radioisotopes. Quantitative measures of NP biodistribution in vivo are needed to determine the effectiveness of these carriers. We have used a model system of radiolabeled quantum dots to document the competition between efficient vascular targeting and interaction of the NP with the reticuloendothelial (RE) system. We have prepared (125m)Te-labeled CdTe NP that are capped with ZnS. Te-125m has a half-life and decay characteristics very similar to those for (125)I. The synthesized particles are stable in aqueous solution and are derivatized with mercaptoacetic acid and then conjugated with specific antibody. To evaluate specific targeting, we used the monoclonal antibody MAb 201B that binds to murine thrombomodulin expressed in the lumen of lung blood vessels. The MAb-targeted NP were tested for targeting performance in vivo using single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging, tissue autoradiography and standard organ biodistribution techniques. Biodistribution was also determined in mice that had been depleted of phagocytic cells by use of clodronate-loaded liposomes. Cd(125m)Te/ZnS NP coupled with MAb 201B retained radioisotope and antibody activity and accumulated in lung (>400% injected dose [ID]/g) within 1 h of intravenous injection. Control antibody-coupled NP did not accumulate in lung (<10% ID/g) but accumulated in liver and spleen. Images from microSPECT/CT and autoradiography studies of the targeted NP document this specific uptake and demonstrate uniform distribution in lung with minor accumulation in liver and spleen. Within a few hours, a large fraction of lung-targeted NP redistributed to spleen and liver or was excreted. We hypothesized that NP attract phagocytic cells that engulfed and removed them from circulation. This was confirmed by comparing biodistribution of targeted NP in normal mice versus those depleted of phagocytic cells. In mice treated with clodronate liposomes, accumulation of NP in liver was reduced by fivefold, while accumulation in lung at 1 h was enhanced by approximately 50%. By 24 h, loss of the targeted NP from lung was inhibited by several-fold, while accumulation in liver and spleen remained constant. Thus, the treated mice had a much larger accumulation and retention of the NP at the target site and a decrease in dose to other organs except spleen. Nanoparticles composed of CdTe, labeled with (125m)Te and capped with ZnS, can be targeted with MAb to sites in the lumen of lung vasculature. In clodronate-treated mice, which have a temporary depletion of phagocytic cells, accumulation in liver was reduced dramatically, whereas that in spleen was not. The targeting to lung was several-fold more efficient in clodronate-treated mice due to larger initial accumulation and better retention of the MAb-targeted NP at that site. This model system indicates that targeting of NP preparations is a competition between the effectiveness of the targeting agent and the natural tendency for RE uptake of the particles. Temporary inhibition of the RE system may enhance the usefulness of NP for drug and radioisotope delivery.

Kennel, Steve J [ORNL; Woodward, Jonathan [ORNL; Rondinone, Adam Justin [ORNL; Wall, Jonathan [ORNL; Mirzadeh, Saed [ORNL

2008-01-01T23:59:59.000Z

500

Energy Efficiency Targets | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Targets Targets Energy Efficiency Targets < Back Eligibility Investor-Owned Utility Program Info State Arkansas Program Type Energy Efficiency Resource Standard In December of 2010, the Arkansas Public Service Commission announced a [http://www.apscservices.info/pdf/08/08-144-U_153_1.pdf Sustainable Energy Resource Action Plan] for Arkansas. Along with this comprehensive plan, the Commission issued 10 Orders directing the state's four electric and three natural gas investor-owned utilities to implement the energy efficiency measures described in the Action Plan. These orders were passed on December 10, 2010. Order 17 in Docket 08-144-U sets sales reductions targets for both electric and gas utilities. The PSC directed these utilities to file comprehensive energy efficiency plans for 2011, 2012, and 2013 with incremental energy