National Library of Energy BETA

Sample records for key drug target

  1. Drug-Target Interaction Predicates Combining Similarities

    E-Print Network [OSTI]

    Daume III, Hal

    Drug-Target Interaction Predicates DataSet Combining Similarities Collective Inference Collective Inference and Multi-Relational Learning for Drug­Target Interaction Prediction Shobeir Fakhraei1, Bert Huang1 and Lise Getoor1,2 Poly-pharmacology Drug Repurposing Drug-Target Interaction Network Studies

  2. Predicting new molecular targets for known drugs

    E-Print Network [OSTI]

    Kaski, Samuel

    ARTICLES Predicting new molecular targets for known drugs Michael J. Keiser1,2 *, Vincent Setola3 drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug­target combinations exist, it would be useful to explore possible

  3. Discovering the Targets of Drugs Via Computational

    E-Print Network [OSTI]

    Discovering the Targets of Drugs Via Computational Systems Biology* Published, JBC Papers in Press is empowering the study of drug action. Studies on biological effects of chemical com- pounds have increased of drugs, with the collective potential to change the nature of drug discovery and pharmacological therapy

  4. DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL DATA

    E-Print Network [OSTI]

    Zeng, Jianyang "Michael"

    DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL.edu.cn Corresponding author In silico prediction of unknown drug-target interactions (DTIs) has become a popular tool for drug repositioning and drug development. A key challenge in DTI prediction lies in integrating multiple

  5. Automated High Throughput Drug Target Crystallography

    SciTech Connect (OSTI)

    Rupp, B

    2005-02-18

    The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

  6. Key Agency Targets Summary _FY 2012_.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousand Cubic Feet) SoldDepartment ofKenThousandtheKevlar andKey5 B

  7. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  8. Predicting Drug-Target Interaction for New Drugs Using Enhanced Similarity Measures and Super-Target Clustering1

    E-Print Network [OSTI]

    Chin, Francis Y.L.

    Predicting Drug-Target Interaction for New Drugs Using Enhanced Similarity Measures and Super.hku.hk, FYLC: chin@cs.hku.hk * To whom correspondence should be addressed. Abstract--Predicting drug-target interaction using computa- tional approaches is an important step in drug discovery and repositioning

  9. Overcoming Drug Resistance by Co-Targeting Marzieh Ayati1

    E-Print Network [OSTI]

    Wong, Limsoon

    , Statistics and Computer Science, University of Tehran, Tehran, Iran Abstract Removal or suppression of key to the drug. Communica- tion to the resistance machinery---e.g., efflux pumps and drug-modifying enzymes

  10. Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System 

    E-Print Network [OSTI]

    Yu, Xiao

    2012-07-16

    Hydrophobic drug paclitaxel nanoparticles (PAX NPs) and pH sensitive hydrogels were prepared in this study to build a colon targeting nanoparticle based drug delivery system for oral administration. Negative charged PAX NPs at the size of 110...

  11. Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic

    E-Print Network [OSTI]

    Daume III, Hal

    Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic Shobeir, USA getoor@cs.umd.edu ABSTRACT The high development cost and low success rate of drug dis- covery from appro- ved drugs. Computational methods can be effective in focu- sing efforts for such drug repurposing

  12. Computational Method for Drug Target Search and Application in Drug Discovery

    E-Print Network [OSTI]

    Chen, Yuzong

    Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind ...

  13. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  14. Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations

    E-Print Network [OSTI]

    Perez-Lopez, Aron R; Turei, Denes; Modos, Dezso; Lenti, Katalin; Korcsmaros, Tamas; Csermely, Peter

    2015-01-01

    Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread perturbations in the human interactome is larger if the binding drugs have side effects, as compared to those which have no reported side effects. Our results showed that in general, drug targets were better spreaders of perturbations than non-target proteins, and in particular, targets of drugs with side effects were also better spreaders of perturbations than targets of drugs having no reported side effects in human protein-protein interaction networks. Colorectal cancer-related proteins were good spreaders and had a high centrality, while type 2 diabetes-related proteins showed an average spreading efficiency and had an average centrality in the human interactome. Moreover, the interactome-distance between drug targets and disease-related proteins was higher in diabetes than in colorectal cancer. Our results may help a better understan...

  15. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

    2012-08-28

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  16. A Key Target for Diabetes Drugs | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in endocrine and metabolic disorders. When activated by the hormone glucagon during fasting, the glucagon receptor triggers the release into the bloodstream of stored glucose...

  17. Target Selection for the LBTI Exozodi Key Science Program

    E-Print Network [OSTI]

    Weinberger, Alycia J; Kennedy, Grant M; Roberge, Aki; Defrère, Denis; Hinz, Philip M; Millan-Gabet, Rafael; Rieke, George; Bailey, Vanessa P; Danchi, William C; Haniff, Chris; Mennesson, Bertrand; Serabyn, Eugene; Skemer, Andrew J; Stapelfeldt, Karl R; Wyatt, Mark C

    2015-01-01

    The Hunt for Observable Signatures of Terrestrial planetary Systems (HOSTS) on the Large Binocular Telescope Interferometer will survey nearby stars for faint emission arising from ~300 K dust (exozodiacal dust), and aims to determine the exozodiacal dust luminosity function. HOSTS results will enable planning for future space telescopes aimed at direct spectroscopy of habitable zone terrestrial planets, as well as greater understanding of the evolution of exozodiacal disks and planetary systems. We lay out here the considerations that lead to the final HOSTS target list. Our target selection strategy maximizes the ability of the survey to constrain the exozodi luminosity function by selecting a combination of stars selected for suitability as targets of future missions and as sensitive exozodi probes. With a survey of approximately 50 stars, we show that HOSTS can enable an understanding of the statistical distribution of warm dust around various types of stars and is robust to the effects of varying levels ...

  18. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  19. CHARACTERIZATION OF MYCOSIN FAMILY PROTEASES, NOVEL DRUG TARGETS OF MYCOBACTERIUM TUBERCULOSIS 

    E-Print Network [OSTI]

    Baird, Hilary

    2007-09-17

    Mycosin-1 a novel drug target. This study aims to clone and characterize Mycosin-1 for further investigation as a drug target. The mycosin-1 and mycosin-2 genes were successfully cloned for later use in expression studies. Mycosin-2 has been included...

  20. Structure-based drug mechanism study and inhibitor design targeting tuberculosis 

    E-Print Network [OSTI]

    Wang, Feng

    2009-05-15

    crystallographic and mass spectroscopic approaches (21). 4 N O N H NH 2 N S NH 2 N N O NH 2 O OH NH 2 OH N H O O NH 2 N O O OH N NH F OO NH 2 NH 2 OH OO OH OH OH NH 2 OH OH NH 2 OH H O O O O O NH O OH OH OH N N N OH OH MeO NH OH N H OH Isoniazid... the drug target - proton ATP synthase, which is a key enzyme for ATP synthesis (38). N Br OH OH N N O O OH F N N H ON N O CF 3 O 2 N O O O O O NH O OH OH OH OH MeO N O OH N N Rifalazil Niroimidazolepyran Diarylquinoline Moxifloxacin Figure 2...

  1. MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells

    E-Print Network [OSTI]

    Gao, Jinming

    MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells Jagadeesh Setti micelle (MFM) system that is encoded with a lung cancer-targeting peptide (LCP), and encapsulated. The LCP-encoded MFM showed significantly increased Rv 6-dependent cell targeting in H2009 lung cancer

  2. Small Molecule Target Identification using Drug Affinity Responsive Target Stability (DARTS)

    E-Print Network [OSTI]

    Lomenick, Brett Eugene

    2013-01-01

    FIGURE 2.8: Resveratrol does not inhibitFIGURE 2.9: Resveratrol target analysis withFIGURE 2.10: Resveratrol target analysis with

  3. One of the main issues with drug delivery is that drugs tend to disperse throughout the entire body, instead of targeting

    E-Print Network [OSTI]

    Metlushko, Vitali

    One of the main issues with drug delivery is that drugs tend to disperse throughout the entire body, instead of targeting the specific site (or area) that it is intended to reach. Therefore, drugs candidates for more focused drug delivery systems is magnetic manipulation of nanoparticles

  4. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservationBio-Inspired Solar FuelTechnologyTel:FebruaryEIA's Today8Topo II: An Enzyme Target

  5. Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology

    E-Print Network [OSTI]

    Kalueff, Allan V.

    Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology Adam , Anna Minasyanb , Pentti Tuohimaab and Allan V. Kalueffa Vitamin D is becoming increasingly recognized metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive

  6. Long Chain Fatty Acyl-Coenzyme A Synthetase as Novel Drug Targets in Cryptosporidium parvum 

    E-Print Network [OSTI]

    Guo, Fengguang

    2014-07-07

    screening hundreds of compounds in vitro and in vivo, fully effective therapeutic agents are still unavailable. The major goal of this study is to explore three long-chain fatty acyl-CoA synthetase (CpACSs) of the parasite as novel drug targets...

  7. International Experience with Key Program Elements of IndustrialEnergy Efficiency or Greenhouse Gas Emissions Reduction Target-SettingPrograms

    SciTech Connect (OSTI)

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-02-02

    Target-setting agreements, also known as voluntary ornegotiated agreements, have been used by a number of governments as amechanism for promoting energy efficiency within the industrial sector. Arecent survey of such target-setting agreement programs identified 23energy efficiency or GHG emissions reduction voluntary agreement programsin 18 countries. International best practice related to target-settingagreement programs calls for establishment of a coordinated set ofpolicies that provide strong economic incentives as well as technical andfinancial support to participating industries. The key program elementsof a target-setting program are the target-setting process,identification of energy-saving technologies and measures usingenergy-energy efficiency guidebooks and benchmarking as well as byconducting energy-efficiency audits, development of an energy-savingsaction plan, development and implementation of energy managementprotocols, development of incentives and supporting policies, monitoringprogress toward targets, and program evaluation. This report firstprovides a description of three key target-setting agreement programs andthen describes international experience with the key program elementsthat comprise such programs using information from the three keytarget-setting programs as well as from other international programsrelated to industrial energy efficiency or GHG emissionsreductions.

  8. Drugs against parasitic diseases: R&D methodologies and issues SECTION III A. H. FAIRLAMB 107 Target discovery and validation with

    E-Print Network [OSTI]

    Schnaufer, Achim

    Drugs against parasitic diseases: R&D methodologies and issues · SECTION III · A. H. FAIRLAMB 107 target for drug discovery and drug development. This article considers the various approaches to target of target validation by chemical and genetic methods. Particular reference is made to the prospects of drug

  9. Inhibin beta E is upregulated by drug-induced endoplasmic reticulum stress as a transcriptional target gene of ATF4

    SciTech Connect (OSTI)

    Brüning, Ansgar, E-mail: ansgar.bruening@med.uni-muenchen.de; Matsingou, Christina; Brem, German Johannes; Rahmeh, Martina; Mylonas, Ioannis

    2012-10-15

    Inhibins and activins are gonadal peptide hormones of the transforming growth factor-? super family with important functions in the reproductive system. By contrast, the recently identified inhibin ?E subunit, primarily expressed in liver cells, appears to exert functions unrelated to the reproductive system. Previously shown downregulation of inhibin ?E in hepatoma cells and anti-proliferative effects of ectopic inhibin ?E overexpression indicated growth-regulatory effects of inhibin ?E. We observed a selective re-expression of the inhibin ?E subunit in HepG2 hepatoblastoma cells, MCF7 breast cancer cells, and HeLa cervical cancer cells under endoplasmic reticulum stress conditions induced by tunicamycin, thapsigargin, and nelfinavir. Analysis of XPB1 splicing and ATF4 activation revealed that inhibin ?E re-expression was associated with induction of the endoplasmic reticulum stress reaction by these drugs. Transfection of an ATF4 expression plasmid specifically induced inhibin ?E expression in HeLa cells and indicates inhibin ?E as a hitherto unidentified target gene of ATF4, a key transcription factor of the endoplasmic reticulum stress response. Therefore, the inhibin ?E subunit defines not only a new player but also a possible new marker for drug-induced endoplasmic reticulum stress. -- Highlights: ? Endoplasmic reticulum stress induces inhibin beta E expression. ? Inhibin beta E is regulated by the transcription factor ATF4. ? Inhibin beta E expression can be used as a marker for drug-induced ER stress.

  10. Drug disposition and targeting: Transport across the blood-brain barrier

    E-Print Network [OSTI]

    Rochat, Bertrand; Audus, Kenneth L.

    1999-01-01

    the BBB. Neutral amino-acid carriers have proven to be capable of transporting many amino acids, drugs and endogenous compounds with similar stuctures. Leucine, cysteine, serine, alanine, phenylalanine, L-dopa, L-tryptophan, the alkylating agent... the carriers for opioids at the BBB have not been resolved. The possibility obviously exists, however, for the design and development of opioid peptide therapeutics that target BBB carriers and achieve improve brain delivery (Thomas et al., 1997). The last...

  11. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Forte, Trudy

    2011-04-28

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  12. Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery

    E-Print Network [OSTI]

    S. Heidegger; S. Niedermayer; A. Schmidt; D. Gößl; C. Argyo; S. Endres; T. Bein; C. Bourquin

    2015-09-03

    Multifunctional mesoporous silica nanoparticles (MSN) have attracted substantial attention with regard to their high potential for targeted drug delivery. For future clinical applications it is crucial to address safety concerns and understand the potential immunotoxicity of these nanoparticles. In this study, we assess the biocompatibility and functionality of multifunctional MSN in freshly isolated, primary murine immune cells. We show that the functionalized silica nanoparticles are rapidly and efficiently taken up into the endosomal compartment by specialized antigen-presenting cells such as dendritic cells. The silica nanoparticles showed a favorable toxicity profile and did not affect the viability of primary immune cells from the spleen in relevant concentrations. Cargo-free MSN induced only very low immune responses in primary cells as determined by surface expression of activation markers and release of pro-inflammatory cytokines such as Interleukin-6, -12 and -1\\beta. In contrast, when surface-functionalized MSN with a pH-responsive polymer capping were loaded with an immune-activating drug, the synthetic Toll-like receptor 7 agonist R848, a strong immune response was provoked. We thus demonstrate that MSN represent an efficient drug delivery vehicle to primary immune cells that is both non-toxic and non-inflammagenic, which is a prerequisite for the use of these particles in biomedical applications.

  13. Current Drug Targets, 2007, 8, 15-30 15 1389-4501/07 $50.00+.00 2007 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    McFadden, Geoff

    Current Drug Targets, 2007, 8, 15-30 15 1389-4501/07 $50.00+.00 © 2007 Bentham Science Publishers Ltd. Fatty Acid Biosynthesis as a Drug Target in Apicomplexan Parasites C.D. Goodman* and G.I. Mc impacts on much of the world's population. The increasing prevalence of drug resistant parasites

  14. Key Elements of and Materials Performance Targets for Highly Insulating Window Frames

    SciTech Connect (OSTI)

    Gustavsen, Arild; Grynning, Steinar; Arasteh, Dariush; Jelle, Bjorn Petter; Goudey, Howdy

    2011-03-28

    The thermal performance of windows is important for energy efficient buildings. Windows typically account for about 30-50 percent of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U-factor of their opaque counterparts (wall, roof and floor constructions). In well insulated buildings the U-factor of walls, roofs an floors can be between 0.1-0.2 W/(m2K). The best windows have U-values of about 0.7-1.0. It is therefore obvious that the U-factor of windows needs to be reduced, even though looking at the whole energy balance for windows (i.e. solar gains minus transmission losses) makes the picture more complex.In high performance windows the frame design and material use is of utmost importance, as the frame performance is usually the limiting factor for reducing the total window U-factor further. This paper describes simulation studies analyzing the effects on frame and edge-of-glass U-factors of different surface emissivities as well as frame material and spacer conductivities. The goal of this work is to define materials research targets for window frame components that will result in better frame thermal performance than is exhibited by the best products available on the market today.

  15. Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery

    E-Print Network [OSTI]

    Heidegger, S; Schmidt, A; Gößl, D; Argyo, C; Endres, S; Bein, T; Bourquin, C

    2015-01-01

    Multifunctional mesoporous silica nanoparticles (MSN) have attracted substantial attention with regard to their high potential for targeted drug delivery. For future clinical applications it is crucial to address safety concerns and understand the potential immunotoxicity of these nanoparticles. In this study, we assess the biocompatibility and functionality of multifunctional MSN in freshly isolated, primary murine immune cells. We show that the functionalized silica nanoparticles are rapidly and efficiently taken up into the endosomal compartment by specialized antigen-presenting cells such as dendritic cells. The silica nanoparticles showed a favorable toxicity profile and did not affect the viability of primary immune cells from the spleen in relevant concentrations. Cargo-free MSN induced only very low immune responses in primary cells as determined by surface expression of activation markers and release of pro-inflammatory cytokines such as Interleukin-6, -12 and -1\\beta. In contrast, when surface-funct...

  16. Call for Papers for 3rd Annual Diabetes Care Symposium "New Drug Therapies, Innovative Management Strategies, and Novel Drug Targets"

    E-Print Network [OSTI]

    Kaski, Samuel

    Call for Papers for 3rd Annual Diabetes Care Symposium "New Drug Therapies, Innovative Management submissions for the 3rd Annual Diabetes Care Symposium, titled "New Drug Therapies, Innovative Management, at http://mc.manuscriptcentral.com/diabetescare. When submitting your manuscript, please mention the 3rd

  17. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

  18. Strategies to Target Pancreatic Cancer Stem Cells using Natural Killer Cells and Chemotherapeutic Drugs

    E-Print Network [OSTI]

    Lanzon, Caitlin Jean

    2015-01-01

    pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management

  19. Example 1: Bioenergetic analysis of combining mitochondria-targeted drugs with 2-deoxyglucose in breast cancer cells

    E-Print Network [OSTI]

    Example 1: Bioenergetic analysis of combining mitochondria-targeted drugs with 2- deoxyglucose in breast cancer cells OVERVIEW The MCW Cancer Center Bioenergetics Shared Resource opened in January 2012 in MFRC 2013. The purpose of the Bioenergetics Shared Resource is four- fold: investigate cancer cell

  20. Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion

    SciTech Connect (OSTI)

    Knobloch, M.; Portier, C.J.; Levionnois, O.L.; Theurillat, R.; Thormann, W.; Spadavecchia, C.; Mevissen, M. . E-mail: meike.mevissen@vpi.unibe.ch

    2006-11-01

    Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 {mu}g/ml S-ketamine over 120 min under isoflurane anesthesia was performed in Shetland ponies. A quantitative electromyographic assessment of the NWR was done before, during and after the TCI. Plasma levels of R-/S-ketamine and R-/S-norketamine were determined by enantioselective capillary electrophoresis. These data and two additional data sets from bolus studies were used to build a PBPk model for ketamine in ponies. The peak-to-peak amplitude and the duration of the NWR decreased significantly during TCI and returned slowly toward baseline values after the end of TCI. The PBPk model provides reliable prediction of plasma and tissue levels of R- and S-ketamine and R- and S-norketamine. Furthermore, biotransformation of ketamine takes place in the liver and in the lung via first-pass metabolism. Plasma concentrations of S-norketamine were higher compared to R-norketamine during TCI at all time points. Analysis of the data suggested identical biotransformation rates from the parent compounds to the principle metabolites (R- and S-norketamine) but different downstream metabolism to further metabolites. The PBPk model can provide predictions of R- and S-ketamine and norketamine concentrations in other clinical settings (e.g. horses)

  1. 1. (a) Why are DNA-targeted drugs largely used as anticancer agents and not as, say, antibacterial or antifungal agents?

    E-Print Network [OSTI]

    Gates, Kent. S.

    CHEM 4170 Homework 4 1. (a) Why are DNA-targeted drugs largely used as anticancer agents and not as, say, antibacterial or antifungal agents? (b) Provide an explanation for how anticancer drugs can-damaging drugs mentioned in Question 1). (b) However, some medicinal chemists believe that these compounds

  2. Abstract--Wave energy will have a key role in meeting re-newable energy targets en route to a low carbon economy. How-

    E-Print Network [OSTI]

    Harrison, Gareth

    1 Abstract--Wave energy will have a key role in meeting re- newable energy targets en route will impact on wave energy conversion. Where the resource is restricted there may be reductions in energy the sensitivity of wave energy production and econom- ics to changes in climate. Index Terms--Wave energy

  3. Developing a commercial production process for 500,000 targets per day: A key challenge for inertial fusion energy

    SciTech Connect (OSTI)

    Goodin, D.T.; Alexander, N.B.; Besenbruch, G.E.; Bozek, A.S.; Brown, L.C.; Flint, G.W.; Kilkenny, J.D.; McQuillan, B.W.; Nikroo, A.; Paguio, R.R.; Petzoldt, R.W.; Schroen, D.G.; Sheliak, J.D.; Vermillion, B.A. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Carlson, L.C.; Goodman, P.; Maksaereekul, W.; Raffray, R.; Spalding, J.; Tillack, M.S. [University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92023 (United States)] (and others)

    2006-05-15

    As is true for current-day commercial power plants, a reliable and economic fuel supply is essential for the viability of future Inertial Fusion Energy (IFE) [Energy From Inertial Fusion, edited by W. J. Hogan (International Atomic Energy Agency, Vienna, 1995)] power plants. While IFE power plants will utilize deuterium-tritium (DT) bred in-house as the fusion fuel, the 'target' is the vehicle by which the fuel is delivered to the reaction chamber. Thus the cost of the target becomes a critical issue in regard to fuel cost. Typically six targets per second, or about 500 000/day are required for a nominal 1000 MW(e) power plant. The electricity value within a typical target is about $3, allocating 10% for fuel cost gives only 30 cents per target as-delivered to the chamber center. Complicating this economic goal, the target supply has many significant technical challenge - fabricating the precision fuel-containing capsule, filling it with DT, cooling it to cryogenic temperatures, layering the DT into a uniform layer, characterizing the finished product, accelerating it to high velocity for injection into the chamber, and tracking the target to steer the driver beams to meet it with micron-precision at the chamber center.

  4. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    Affairs (DEFRA), 2005. UK Emissions Trading Scheme. http://targets through the UK Emissions Trading Scheme. 6 Table 1is to be adjusted for emissions trading. The reports must be

  5. EhCP1 and EhCP5 : key released cysteine proteinases of Entamoeba histolytica as drug targets

    E-Print Network [OSTI]

    Ta, Jasmine

    2012-01-01

    model of cecal amebiasis using CBA/J mice (He et al, 2010).al, 2010). Six week old male CBA/J mice (Jackson Laboratory,of amebiasis. Six-week old male CBA/J mice were pretreated

  6. Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: A persistence gene and protein drug target

    SciTech Connect (OSTI)

    Kantardjieff, K A; Vasquez, C; Castro, P; Warfel, N M; Rho, B; Lekin, T; Kim, C; Segelke, B W; Terwilliger, T C; Rupp, B

    2004-09-24

    The 1.9 {angstrom} native structure of pyrimidine biosynthesis regulatory protein encoded by the Mycobacterium tuberculosis pyrR gene (Rv1379) is reported. Because pyrimidine biosynthesis is an essential step in the progression of TB, pyrR is an attractive antitubercular drug target. The Mycobacterium tuberculosis pyrR gene (Rv1379) encodes a protein that regulates expression of pyrimidine nucleotide biosynthesis (pyr) genes in a UMP-dependent manner. Because pyrimidine biosynthesis is an essential step in the progression of TB, the gene product pyrR is an attractive antitubercular drug target. We report the 1.9 {angstrom} native structure of Mtb pyrR determined by the TB Structural Genomics Consortium facilities (PDB entry 1W30) in trigonal space group P3{sub 1}21, with cell dimensions at 120K of a = 66.64 {angstrom}, c = 154.72 {angstrom}, and two molecules in the asymmetric unit. The 3D structure and residual uracil phosphoribosyltransferase activity point to a common PRTase ancestor for pyrR. However, while PRPP and UMP binding sites have been retained in Mtb pyrR, a novel dimer interaction among subunits creates a deep, positively charged cleft capable of binding pyr mRNA. In silico screening of pyrimidine nucleoside analogs has revealed a number of potential leads compounds that, if bound to Mtb pyrR, could facilitate transcriptional attenuation, particularly cyclopentenyl nucleosides.

  7. Targets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservationBio-Inspired Solar Fuel ProductionRecoverable User Guide Nuclear ScienceTargets

  8. Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes

    E-Print Network [OSTI]

    Manikwar, Prakash; Tejo, Bimo A.; Shinogle, Heather; Moore, David S.; Zimmerman, Tahl; Blanco, Francisco; Siahaan, Teruna J.

    2010-05-10

    to deliver drugs to cells with upregulated ICAM-1. Anti-ICAM-1-coated nanopar- ticles successfully delivered lysosomal enzyme into cells obtained from patients suffering from lysosomal storage disorder [34]. These nanoparticles are endo- cytosed via a non... blocks the I-domain binding site to ICAM-1 (Fig. 4). A similar effect of the mAb was observed in the binding of a GST-tagged I-domain (I-GST) to a surface-coated ICAM-1Fc using a solid-phase ELISA assay [29]. The antibody blocking studies indicate...

  9. Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design

    E-Print Network [OSTI]

    AhYoung, AP; Koehl, A; Cascio, D; Egea, PF

    2015-01-01

    falciparum: Targeting protein folding and secretion forfalciparum: targeting protein folding and secretion for

  10. Crucial stages of protein folding through a solvable model: Predicting target sites

    E-Print Network [OSTI]

    Cecconi, Fabio

    Crucial stages of protein folding through a solvable model: Predicting target sites for enzyme. Keywords: Protein-folding modeling; prediction of key folding sites; HIV-1 protease; drug resistance One

  11. Systems Theory for Pharmaceutical Drug Discovery

    E-Print Network [OSTI]

    Aswani, Anil Jayanti

    2010-01-01

    model to identify multiple drug targets which can be candidates for the traditional process of drug discovery.

  12. A Study of Telomeres-Targeting Anticancer Drugs' Effectiveness through Comparative Cancer Mortality and Incidence Rates Analysis

    E-Print Network [OSTI]

    Urio, Richard O.

    2015-07-30

    of Human Genome Project (HGP) in 2003 will be discussed. The HGP had among its main three future goals the designing of more robust and efficient drugs, vaccines and therapies for cancer prevention or elimination. Analyzing the success of the anticancer.... Completion of the human genome project (HGP) on April 14, 2003 was an exciting moment for people in medical research, as it culminated in successful mapping of the entire human body building blocks, or genes. With completion of this project...

  13. KEY PERSONNEL

    National Nuclear Security Administration (NNSA)

    KEY PERSONNEL 7062015 TITLE NAME President Christopher C. Gentile Vice President, Engineering Robin Stubenhofer Vice President, Integrated Supply Chain Rick Lavelock Director,...

  14. PHCL4003: Anti-infective drugs: Drugs that kill invaders -2015 Spring Course Co-Directors

    E-Print Network [OSTI]

    Marchant, Jonathan

    1 PHCL4003: Anti-infective drugs: Drugs that kill invaders - 2015 Spring Course Co to antimicrobial chemotherapy Jan. 26: 2. Principles of antibacterial drugs I: Drug targets and cytotoxicity Jan. 28: 3. Principles of antibacterial drugs II: Drug resistance Feb. 2: 4. Antibacterial drugs

  15. An approach to drug delivery using novel carbohydrates to carry drugs

    E-Print Network [OSTI]

    Davis, Ben G.

    An approach to drug delivery using novel carbohydrates to carry drugs has recently been described of the cancer drug doxorubicin targeted to hepatocytes in a mouse liver tumour model. Known as the LEAPT step involves administering the rhamnose-capped pro-drug; the drug is activated in the target cell once

  16. New Directions for Cancer Drug Research of Ruthenium and Rhodium Compounds: Investigation of Cytotoxicities, Mechanisms of Cancer Cell Death, and Cellular Targets 

    E-Print Network [OSTI]

    Pena Maceda, Bruno

    2014-07-02

    The discovery of the antitumor properties of cisplatin revolutionized the field of medicinal inorganic chemistry and fostered the development of metal-based anticancer drugs, a topic that continues to play a prominent role ...

  17. Mechanical loading impacts intramuscular drug transport : impact on local drug delivery

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2008-01-01

    Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue ...

  18. Antiarrhythmic Drugs

    E-Print Network [OSTI]

    Abbott, GW; Levi, R

    2012-01-01

    of beta blockers: from antianginal drugs to ligand-directedmechanisms of gating and drug block of sodium channels.Roden DM. Antiarrhythmic drugs: past, present and future. J

  19. Antigen-specific blocking of immunological synapse formation using bifunctional peptide, Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes

    E-Print Network [OSTI]

    Manikwar, Prakash; Tejo, Bimo A.; Shinogle, Heather; Moore, David S.; Zimmerman, Tahl; Blanco, Francisco; Siahaan, Teruna J.

    2011-05-01

    to deliver drugs to cells with upregulated ICAM-1. Anti-ICAM-1-coated nanopar- ticles successfully delivered lysosomal enzyme into cells obtained from patients suffering from lysosomal storage disorder [34]. These nanoparticles are endo- cytosed via a non... blocks the I-domain binding site to ICAM-1 (Fig. 4). A similar effect of the mAb was observed in the binding of a GST-tagged I-domain (I-GST) to a surface-coated ICAM-1Fc using a solid-phase ELISA assay [29]. The antibody blocking studies indicate...

  20. Focus Article Open challenges in magnetic drug

    E-Print Network [OSTI]

    Shapiro, Benjamin

    Focus Article Open challenges in magnetic drug targeting Benjamin Shapiro,1,2 Sandip Kulkarni,1 Aleksander Nacev,3 Silvia Muro,1,4 Pavel Y. Stepanov3 and Irving N. Weinberg3 The principle of magnetic drug is that highlight- ing these challenges will help researchers translate magnetic drug targeting from a novel concept

  1. Assess the key physics that underpins high-hydro coupling-efficiency in NDCX-II experiments and high-gain heavy ion direct drive target designs using proven hydro codes like HYDRA

    E-Print Network [OSTI]

    Barnard, J. J.

    2010-01-01

    and J. Meyer-Ter- Vehn, The Physics of Inertial Fusion: BeamREPORT Assess the key physics that underpins high-hydroand J. Meyer-Ter-Vehn, The Physics o f Inertial Fusion: Beam

  2. Assess the key physics that underpins high-hydro coupling-efficiency in NDCX-II experiments and high-gain heavy ion direct drive target designs using proven hydro codes like HYDRA

    E-Print Network [OSTI]

    Barnard, J. J.

    2010-01-01

    analysis o f direct drive fusion energy targets using heavyof Science, Office of Fusion Energy Sciences, of the U.S.of Science, Office of Fusion Energy Sciences, of the U.S.

  3. Assess the key physics that underpins high-hydro coupling-efficiency in NDCX-II experiments and high-gain heavy ion direct drive target designs using proven hydro codes like HYDRA

    E-Print Network [OSTI]

    Barnard, J. J.

    2010-01-01

    physics that underpins high-hydro coupling-efficiency in N Dtarget designs using proven hydro codes like H Y D R A . byF E targets, we have studied hydro and implosion efficiency

  4. Assess the key physics that underpins high-hydro coupling-efficiency in NDCX-II experiments and high-gain heavy ion direct drive target designs using proven hydro codes like HYDRA

    SciTech Connect (OSTI)

    Barnard, J. J.; Hay, M. J.; Logan, B. G.; Ng, S. F.; Perkins, L. J.; Veitzer, S.; Yu, S. S.

    2010-07-01

    The simulations provided in this milestone have solidified the theoretical underpinning of direct drive targets and also the ability to design experiments on NDCX II that will enhance our understanding of ion-beam hydrodynamic coupling, and thus be relevant to IFE. For the case of the IFE targets, we have studied hydro and implosion efficiency using HYDRA in ID, a starting point towards the goal of polar direct drive in geometry compatible with liquid wall chambers. Recent analysis of direct drive fusion energy targets using heavy ion beams has found high coupling efficiency of ion beam energy into implosion energy. However, to obtain optimal coupling, the ion energy must increase during the pulse in order to penetrate the outflowing ablated material, and deposit the energy close enough to the fuel so that the fuel achieves sufficient implosion velocity. We have computationally explored ID (radial) time dependent models of ion driven direct drive capsule implosions using the Arbitrary Lagrangian-Eulerian (ALE) code HYDRA, to help validate the theoretical analysis done so far, particularly exploring the effects of varying the ion energy and ion current over the course of the pulse. On NDCX II, experiments have been proposed to explore issues of ion penetration of the outflowing plasma over the course of the ion pulse. One possibility is to create a first pulse of ions that heats a planar target, and produces an outflow of material. A second pulse, {approx}10 ns after the first, of higher ion energy (and hence larger projected range) will interact with this outflow before reaching and further heating the target. We have investigated whether the change in range can be tailored to match the evolution of the ablation front. We have carried out simulations using the one-dimensional hydrodynamic code DISH and HYDRA to set parameters for this class of experiments. DISH was upgraded with an ion deposition algorithm, and we have carried out ID (planar) simulations. HYDRA was also used for ID (planar) and 2D (r,z) simulations of potential experiments. We have also explored whether similar physics could be studied using an energy ramp (i.e., a velocity tilt) rather than two separate pulses. We have shown that an optimum occurs in the macropulse duration (with fixed velocity tilt) that maximizes the shock strength. In the area of IFE target design we have continued to explore direct drive targets composed of deuterium-tritium fuel and ablator layers. We have extended our previous target designs at 0.44 MJ drive energy, gain 50, (50 MeV foot, 500 MeV main pulse, Rb ion, which requires a large number of beams due to a high beam space charge constraint) to a power plant scale 3.7 MJ drive energy, gain {approx}150 (220 MeV foot, 2.2 GeV main pulse, Hg ion) that eases requirements on the accelerator. We have studied the effects of two important design choices on ICF target performance. We have shown that increasing the number of foot pulses may reduce the target's in-flight adiabat and consequently improve its compressibility and fusion yield. As in the case of laser drive, the first three shocks are the most important to the target's performance, with additional shocks contributing only marginally to compression and burn. We have also demonstrated that ion range lengthening during the main pulse can further reduce the target adiabat and improve the efficiency with which beam energy is coupled into the target. (Ion range lengthening using two different kinetic energies for the foot and main pulse has previously proven effective in the design of high gain targets).

  5. Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity

    E-Print Network [OSTI]

    2012-01-01

    blood pressure lowering drugs: analysis of 354 randomisedKSHV) with combinatory drugs. Integr Biol (Camb). 2009;1(1):matrix metalloproteinases as drug targets and anti-targets

  6. High Power Target Design and Operational Considerations

    E-Print Network [OSTI]

    McDonald, Kirk

    of Energy SNS Target Systems and Status Update Target R&D Program Has Addressed Key Design and Operational-Battelle for the U.S. Department of Energy SNS Target Systems and Status Update Mercury target development activities.S. Department of Energy SNS Target Systems and Status Update · Peak energy deposition in Hg for a single pulse

  7. Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency

    E-Print Network [OSTI]

    Cheng, Jianjun

    Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative LoadingChampaign, Urbana, Illinois 61801, United States Key Laboratory of Smart Drug Delivery, Ministry of Education-molecule drugs in hydrophobic polymers or amphiphilic copolymers has been extensively used for preparing

  8. Public Key Cryptography and Key Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-02-15

    The use and management of certificate-based public key cryptography for the Department of Energy (DOE) requires the establishment of a public key infrastructure (PKI). This chapter defines the policy related to roles, requirements, and responsibilities for establishing and maintaining a DOE PKI and the documentation necessary to ensure that all certificates are managed in a manner that maintains the overall trust required to support a viable PKI. Canceled by DOE N 251.112.

  9. Key Milestones/Outlook

    Broader source: Energy.gov [DOE]

    Key Milestones/Outlook per the Department of Energy 2015 Congressional Budget Request, Environmental Management, March 2014

  10. Key Events Timeline

    Broader source: Energy.gov [DOE]

    This document lists key events beginning with the April 20 fire on the Deepwater Horizon through July 28th. Updated July 28, 2010.

  11. Optical key system

    DOE Patents [OSTI]

    Hagans, Karla G. (Livermore, CA); Clough, Robert E. (Danville, CA)

    2000-01-01

    An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

  12. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01

    Throwing Away the Key or the Taxpayer’s Money? Santa Monica,sell these drugs has cost taxpayers billions of dollars eachdiffusely and the individual taxpayer cannot easily measure

  13. Cancer Cell Sox4 Is a Key Oncogenic Target

    E-Print Network [OSTI]

    expression is inversely correlated with C/EBPa activity. Downregulation of Sox4 abro- gated increased self-renewal (LICs) from both Sox4 overexpression and murine C/EBPa mutant AML models clus- tered together

  14. Brain science, addiction and drugs

    E-Print Network [OSTI]

    Wiesner, Karoline

    Designing your future Page 7 Theme: Nanoscience and Quantum Information Exchanging keys in the Canaries Page:searchUniversity of Bristol · Research Review · Issue 10 · October 2005 research themes issue #12;Research themes 2005 Establishedresearchthemes Theme: Neuroscience Brain science, addiction and drugs Other established research themes

  15. Cryptographic Key Management System

    SciTech Connect (OSTI)

    No, author

    2014-02-21

    This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene#12;ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

  16. Key Reference Agilent Technologies

    E-Print Network [OSTI]

    Anlage, Steven

    is provided "as is", and is subject to being changed, without notice, in future editions. Further with the User and should any of the contract terms conflict with these terms, the contract terms shall control enables you to define the number of points in a step sweep. When you press this key, the current value

  17. Key Research Results Achievement

    E-Print Network [OSTI]

    ) evaluated several common figures of merit used to compare the electrical and optical performance of TCsKey Research Results Achievement NREL research significantly contributed to inadequate existing not yet at performance levels of TCOs, demonstrate a much better combination of transmission

  18. Key Research Results Achievement

    E-Print Network [OSTI]

    % energy savings in new buildings and major renovations. Researchers at the National Renewable Energy%energysavingsovercode.NREL developedthesimulationtoolsandledthe committeethatproducedtheguides. Key Result TheAdvancedEnergy to use signifi- cantly less energy--reducing operating costs and greenhouse gas emissions. This new K-12

  19. Target assembly

    DOE Patents [OSTI]

    Lewis, Richard A. (Falls Church, VA)

    1980-01-01

    A target for a proton beam which is capable of generating neutrons for absorption in a breeding blanket includes a plurality of solid pins formed of a neutron emissive target material disposed parallel to the path of the beam and which are arranged axially in a plurality of layers so that pins in each layer are offset with respect to pins in all other layers, enough layers being used so that each proton in the beam will strike at least one pin with means being provided to cool the pins. For a 300 mA, 1 GeV beam (300 MW), stainless steel pins, 12 inches long and 0.23 inches in diameter are arranged in triangular array in six layers with one sixth of the pins in each layer, the number of pins being such that the entire cross sectional area of the beam is covered by the pins with minimum overlap of pins.

  20. NATURE BIOTECHNOLOGY VOLUME 25 NUMBER 10 OCTOBER 2007 1111 and drugs that act directly on disease genes.

    E-Print Network [OSTI]

    Kay, Mark A.

    NATURE BIOTECHNOLOGY VOLUME 25 NUMBER 10 OCTOBER 2007 1111 and drugs that act directly on disease an increase in drugs that target the genes asso- ciated with disease. Networkbiologymayalsoplayaroleindrug- target identification. Is it possible to identify drug targets from their position in a biological

  1. Key Management in Historical Context

    E-Print Network [OSTI]

    ;Rolling Keys Why change keys? --- cryptoperiod (intrinsic to cryptosystem) --- management issuesKey Management in Historical Context Whitfield Diffie Internet Corporation for Assigned Names to become the security or insecurity of the message. #12;Key management systems both reflect and shape

  2. Accelerator target

    DOE Patents [OSTI]

    Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

    1999-06-29

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

  3. Accelerator target

    DOE Patents [OSTI]

    Schlyer, David J. (Bellport, NY); Ferrieri, Richard A. (Patchogue, NY); Koehler, Conrad (Miller Place, NY)

    1999-01-01

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  4. Target Chamber

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S. Coal StocksSuppliers Tag:TakeSeptember 13,TaraTarget Chamber

  5. Targeting NRF2 signaling for cancer chemoprevention

    SciTech Connect (OSTI)

    Kwak, Mi-Kyoung; Kensler, Thomas W.

    2010-04-01

    Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

  6. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)

    1993-01-01

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  7. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  8. Motivation HDFs Algorithms Cross Validation Predictions Combating Viruses by Targeting Host Proteins

    E-Print Network [OSTI]

    Zhang, Liqing

    Motivation HDFs Algorithms Cross Validation Predictions Combating Viruses by Targeting Host Combating Viruses by Targeting Host Proteins #12;Motivation HDFs Algorithms Cross Validation Predictions Proteins #12;Motivation HDFs Algorithms Cross Validation Predictions Pathogens are Becoming Drug

  9. Target-guided synthesis approach to the discovery of novel bivalent inhibitors of Glutathione Transferases 

    E-Print Network [OSTI]

    Clipson, Alexandra Jayne

    2012-06-22

    Target-guided synthesis is an approach to drug discovery that uses the biological target as a template to direct synthesis of its own best inhibitors from small molecule fragments. The process bridges the gap between ...

  10. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  11. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  12. Policy on Keys and Keycards Policy on Keys and Keycards

    E-Print Network [OSTI]

    Sridhar, Srinivas

    department is responsible for the total cost of lock changes and new keys/cards to secure areas compromised has been compromised, and avoid potentially significant costs due to theft, vandalism, or excessive be given access to keys/cards that permit entry to buildings and locked spaces on the University campuses

  13. Drug interactions evaluation: An integrated part of risk assessment of therapeutics

    SciTech Connect (OSTI)

    Zhang, Lei; Reynolds, Kellie S.; Zhao, Ping [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States); Huang, Shiew-Mei, E-mail: shiewmei.huang@fda.hhs.go [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States)

    2010-03-01

    Pharmacokinetic drug interactions can lead to serious adverse events or decreased drug efficacy. The evaluation of a new molecular entity's (NME's) drug-drug interaction potential is an integral part of risk assessment during drug development and regulatory review. Alteration of activities of enzymes or transporters involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by concomitant drugs may alter drug exposure, which can impact response (safety or efficacy). The recent Food and Drug Administration (FDA) draft drug interaction guidance ( (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072101.pdf)) highlights the methodologies and criteria that may be used to guide drug interaction evaluation by industry and regulatory agencies and to construct informative labeling for health practitioner and patients. In addition, the Food and Drug Administration established a 'Drug Development and Drug Interactions' website to provide up-to-date information regarding evaluation of drug interactions ( (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm080499.htm)). This review summarizes key elements in the FDA drug interaction guidance and new scientific developments that can guide the evaluation of drug-drug interactions during the drug development process.

  14. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concept V. Graves Target Studies EVO April 11, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Concept 11 Apr 2012 Target Vessel;3 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Concept 11 Apr 2012 Starting Point

  15. NAME GRAD'NG KEY .

    E-Print Network [OSTI]

    MA 165 EXAM 3 Fall 2002 Page 1/4. NAME GRAD'NG KEY . Page 1 / 18. STUDENT ID Page 2 / 32. Page 3 /18. RECITATION INSTRUCTOR. Page 4 / 32.

  16. Diversity & Flexibility Key to Sustainability | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Diversity & Flexibility Key to Sustainability Diversity & Flexibility Key to Sustainability Plenary V: Biofuels and Sustainability: Acknowledging Challenges and Confronting...

  17. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concept Update V. Graves T. Lessard Target Studies EVO June 26, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 of Energy Target Vessel Update 26 June 2012 Review - Mercury Module Extraction #12;4 Managed by UT

  18. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concept Update V. Graves Target Studies EVO June 12, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 12 June 2012 Review ­ IPAC #12;3 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 12 June 2012 Inner

  19. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concepts Updated 4/16/12 V. Graves Target Studies EVO April 11, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Concept 16 Apr 2012 Target Vessel Requirements · Accurate jet placement · Jet/beam dump pool · Double containment of mercury

  20. A Study of Scotland's Emission and Energy Targets 

    E-Print Network [OSTI]

    Reeve, Rebecca

    2011-11-24

    This dissertation assesses the keys drivers that led to the choice of Scotland’s ambitious climate change targets and the feasibility of meeting them. It also assesses the social, economic or environmental implications of ...

  1. Efficient algorithms for a scheduling problem and its applications to illicit drug market crackdowns

    E-Print Network [OSTI]

    Krovi, Venkat

    scheduling problem. By duality we transform a special case of the drug market crackdown scheduling problemEfficient algorithms for a scheduling problem and its applications to illicit drug market for the general case of the drug market crackdown scheduling problem with monomial cost functions. key words: job

  2. Exanthematous allergic drug reactions due to four chemically unrelated drugs

    E-Print Network [OSTI]

    Gupta, Ramji; Gupta, Sameer

    2008-01-01

    16. Lachgar T, Touil Y. The drug hypersensitivity syndromeW, Bircher A, Romano A et al. Drug provocation testing inthe diagnosis of drug hypersensitivity reactions: general

  3. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concept V. Graves Target Studies EVO May 1, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Concept 1 May 2012 Review ­ Two Target Vessel Ideas · Solid-Battelle for the U.S. Department of Energy Target Vessel Concept 1 May 2012 #12;4 Managed by UT-Battelle for the U

  4. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, R.J.

    1984-10-10

    A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

  5. Electrically charged targets

    DOE Patents [OSTI]

    Goodman, Ronald K. (Livermore, CA); Hunt, Angus L. (Alamo, CA)

    1984-01-01

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  6. Gastric H,K-ATPase as a drug target

    E-Print Network [OSTI]

    Shin, Jai M; Sachs, G

    2006-01-01

    cations. J Biol Chem Fukushima Y, Nakao M: Changes inChem 1980;255(16):7813-9. Fukushima Y, Post RL: Binding of

  7. Study reveals structure of tuberculosis enzyme, could offer drug target |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation ofAlbuquerque|SensitiveAprilPhotonStructureStudents today. AtStart

  8. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.Week DayDr.Theories81 toDepartment ofTopo II: An Enzyme

  9. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.Week DayDr.Theories81 toDepartment ofTopo II: An EnzymeTopo

  10. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.Week DayDr.Theories81 toDepartment ofTopo II: An

  11. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.Week DayDr.Theories81 toDepartment ofTopo II: AnTopo II: An

  12. MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design

    E-Print Network [OSTI]

    Powers, Robert

    MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design by Coupling to evaluate ligand binding with an obvious utility in structure-based drug discovery and design.7-10 The "SAR to bind a target protein while obtaining structure-related information as part of a struc- ture-based drug

  13. Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP)

    E-Print Network [OSTI]

    Charette, André

    Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP) Neurodegenerative diseases represent one of the most difficult classes of diseases for which to develop drugs, yet, offering a huge opportunity to target some of these pathways with repurposed drugs approved

  14. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01

    and the risk of illicit drug use: the Adverse Childhoodalcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.

  15. Key China Energy Statistics 2012

    SciTech Connect (OSTI)

    Levine, Mark; Fridley, David; Lu, Hongyou; Fino-Chen, Cecilia

    2012-05-01

    The China Energy Group at Lawrence Berkeley National Laboratory (LBNL) was established in 1988. Over the years the Group has gained recognition as an authoritative source of China energy statistics through the publication of its China Energy Databook (CED). The Group has published seven editions to date of the CED (http://china.lbl.gov/research/chinaenergy-databook). This handbook summarizes key statistics from the CED and is expressly modeled on the International Energy Agency’s “Key World Energy Statistics” series of publications. The handbook contains timely, clearly-presented data on the supply, transformation, and consumption of all major energy sources.

  16. Key China Energy Statistics 2011

    SciTech Connect (OSTI)

    Levine, Mark; Fridley, David; Lu, Hongyou; Fino-Chen, Cecilia

    2012-01-15

    The China Energy Group at Lawrence Berkeley National Laboratory (LBNL) was established in 1988. Over the years the Group has gained recognition as an authoritative source of China energy statistics through the publication of its China Energy Databook (CED). In 2008 the Group published the Seventh Edition of the CED (http://china.lbl.gov/research/chinaenergy-databook). This handbook summarizes key statistics from the CED and is expressly modeled on the International Energy Agency’s “Key World Energy Statistics” series of publications. The handbook contains timely, clearly-presented data on the supply, transformation, and consumption of all major energy sources.

  17. Key Issues | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested Parties - WAPA Public CommentInverted253.16582104) Kenmore:Key2: ProjectKey

  18. Key Steps | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse Bergkamp Graduate student Subtask 4Photo4> TheKevin MorrisKeyKey Steps

  19. Magnetically attached sputter targets

    DOE Patents [OSTI]

    Makowiecki, D.M.; McKernan, M.A.

    1994-02-15

    An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

  20. Architecture BA (Hons) Key details

    E-Print Network [OSTI]

    Painter, Kevin

    Architecture BA (Hons) Key details Duration: 4 years (honours degree) Delivery type: Day Intake in the subject of Architecture, including a portfolio of Design, Technical and Theoretical courses covering all aspects of Architectural Theory and Practice. The course has been designed with reference to the RIBA

  1. INFORMATION: THE KEY TO SUSTAINABILITY

    E-Print Network [OSTI]

    Bateman, Ian J.

    of construction and demolition wastes and the introduction of demolition plans. Examples of information sources in the UK, Europe and the US are provided. Key words: waste management, construction, demolition, secondary sector so are concerned with re-use and recycling construction and demolition waste (C & D). However many

  2. Orphanet Berichtsreihe Orphan Drugs Datenerhebung

    E-Print Network [OSTI]

    Manstein, Dietmar J.

    Orphanet Berichtsreihe Orphan Drugs Datenerhebung Verzeichnis der in Europa zugelassenen Orphan Drugs Mit europäischer Orphan-Drug-Designation und europäischer Marktzulassung* Mit europäischer Marktzulassung* ohne vorherige Orphan-Drug-Designation *Zentrales Zulassungsverfahren der Europäischen

  3. First SNS Target Replacement

    E-Print Network [OSTI]

    McDonald, Kirk

    ) used to drain the mercury to a shielded storage tank is the only active element. · However, the process · A shielded "Target Service Bay" located downstream of the target-proton beam interaction monolith serves

  4. Few-key Text Entry Revisited: Mnemonic Gestures on Four Keys

    E-Print Network [OSTI]

    Wobbrock, Jacob O.

    of Roman letters for high learnability. We compare this new 4-key method to predominant 3-key and 5-key present a new 4-key method that relies on mnemonic gestures reminiscent of Roman letters. Our method-key methods rely on two keys to move a selector left and right and a third key to select a letter. Although

  5. High Power Cryogenic Targets

    SciTech Connect (OSTI)

    Gregory Smith

    2011-08-01

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  6. Identify key design elements of desired function

    E-Print Network [OSTI]

    Nawroth, Janna C.

    DESIGN Identify key design elements of desired function Identify functionally equivalent implementation of key design elements (e.g. structure, physiology, kinematics etc.) Quantify functional and standardize fabrication for repeatability . Test phase: Quantify implementation of key design elements

  7. Key Activities | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested Parties - WAPA Public CommentInverted253.16582104) Kenmore:Key

  8. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  9. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Brain Receptor Structures Key to Future Therapeutics Print Wednesday, 28 January 2015 00:00 With an aging population in...

  10. Key Opportunities and Challenges for Program Sustainability ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Opportunities and Challenges for Program Sustainability Key Opportunities and Challenges for Program Sustainability Better Buildings Neighborhood Program, Peer Exchange Call:...

  11. Small Molecule Target Identification using Drug Affinity Responsive Target Stability (DARTS)

    E-Print Network [OSTI]

    Lomenick, Brett Eugene

    2013-01-01

    vehicle control, or with celecoxib (Panacea Biotec Ltd. ,mTOR-rapamycin, COX-2–celecoxib, and Smer3-Met30 (8) (Figuredidemnin B with eEF1A, celecoxib with COX-2, and Smer3 with

  12. Basics about CIM technology and key

    E-Print Network [OSTI]

    Lebendiker, Mario

    FDA audit for one of the projects. · 2010: Drug Master File (DMF) for CIM® SO3 supports. · 2001 - 2010) for CIM® DEAE, QA and SO3 columns in place, HIC in preparation. First drug purified using CIM monoliths

  13. Key Activities | Department of Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousand Cubic Feet) SoldDepartment ofKenThousandtheKevlar andKey

  14. Key Terms | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuelsof EnergyApril 2014 | International NuclearKaren AtkinsonAbout the FuelKey

  15. MULTIVARIATE PUBLIC KEY CRYPTOSYSTEMS FROM DIOPHANTINE EQUATIONS

    E-Print Network [OSTI]

    Gao, Shuhong

    MULTIVARIATE PUBLIC KEY CRYPTOSYSTEMS FROM DIOPHANTINE EQUATIONS SHUHONG GAO AND RAYMOND HEINDL for multivariate public key cryptosystems, which combines ideas from both triangular and oil-vinegar schemes. We the framework. 1. Introduction 1.1. Multivariate Public Key Cryptography. Public key cryptography plays

  16. "...powered bodies turn to commodities..." -stereolab Drugs and Drug Abuse

    E-Print Network [OSTI]

    Teissére, Jeremy Alden

    "...powered bodies turn to commodities..." - stereolab BIO 115 Fall, 2008 Drugs and Drug Abuse the current narratives surrounding drug use. In parallel, we will closely examine the putative mechanisms by which drugs act in the central nervous system ­ and also discuss how the action of these drugs has

  17. Drug delivery Sustained Drug Release from Non-eroding Nanoporous

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Drug delivery Sustained Drug Release from Non-eroding Nanoporous Templates** Evin Gultepe, Dattatri drug, doxorubicin (Dox), from different non-eroding nanopor- ous coatings. Detailed studies of drug phosphate-buffered saline (PBS), which is commonly employed to simulate in vivo conditions for drug release

  18. TARGET SPECIES Table 1. Terrestrial target species.

    E-Print Network [OSTI]

    that have only one or a very few number of key ecological functions. Functional specialist species could = Critical functional link species, species that are the only ones that perform a specific ecological Merganser Boreal Toad Wolverine FS Horned Grebe Long-toed Salamander CFLS BIRDS House Finch CFLS Northern

  19. Quantum Key Distribution with Qubit Pairs

    E-Print Network [OSTI]

    Mohd Asad Siddiqui; Tabish Qureshi

    2014-07-17

    We propose a new Quantum Key Distribution method in which Alice sends pairs of qubits to Bob, each in one of four possible states. Bob uses one qubit to generate a secure key and the other to generate an auxiliary key. For each pair he randomly decides which qubit to use for which key. The auxiliary key has to be added to Bob's secure key in order to match Alice's secure key. This scheme provides an additional layer of security over the standard BB84 protocol.

  20. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

    SciTech Connect (OSTI)

    Hast, Michael A.; Nichols, Connie B.; Armstrong, Stephanie M.; Kelly, Shannon M.; Hellinga, Homme W.; Alspaugh, J. Andrew; Beese, Lorena S.

    2012-09-17

    Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals, including AIDS patients and transplant recipients. Few antifungals can treat C. neoformans infections, and drug resistance is increasing. Protein farnesyltransferase (FTase) catalyzes post-translational lipidation of key signal transduction proteins and is essential in C. neoformans. We present a multidisciplinary study validating C. neoformans FTase (CnFTase) as a drug target, showing that several anticancer FTase inhibitors with disparate scaffolds can inhibit C. neoformans and suggesting structure-based strategies for further optimization of these leads. Structural studies are an essential element for species-specific inhibitor development strategies by revealing similarities and differences between pathogen and host orthologs that can be exploited. We, therefore, present eight crystal structures of CnFTase that define the enzymatic reaction cycle, basis of ligand selection, and structurally divergent regions of the active site. Crystal structures of clinically important anticancer FTase inhibitors in complex with CnFTase reveal opportunities for optimization of selectivity for the fungal enzyme by modifying functional groups that interact with structurally diverse regions. A substrate-induced conformational change in CnFTase is observed as part of the reaction cycle, a feature that is mechanistically distinct from human FTase. Our combined structural and functional studies provide a framework for developing FTase inhibitors to treat invasive fungal infections.

  1. Fixed drug eruption caused by the Japanese herbal drug kakkonto

    E-Print Network [OSTI]

    Furuichi, Megumi; Hara, Hiroshi; Asano, Yukie; Makino, Teruhiko; Shimizu, Tadamichi

    2010-01-01

    Topical provocation of fixed drug eruption. Br J Dermatol.neglected offender for fixed drug eruptions. Eur J Dermatoloral and non-oral herbal drugs may cause FDE. References 1.

  2. Drug Use and Drug Policy in a Prohibition Regime

    E-Print Network [OSTI]

    MacCoun, Robert; Martin, Karin D.

    2008-01-01

    Prisoners (prior to offense), Drug-related Emergency RoomVisits, 2007 DAWN All illicit drugs Marijuana Cocaine Crack2/4/2008 - 41 Other Sentence Drug Sentence Federal Prisoners

  3. REVIEWS Drug Discovery Today Volume 13, Numbers 3/4 February 2008 The application of FAST-NMR for the

    E-Print Network [OSTI]

    Powers, Robert

    REVIEWS Drug Discovery Today Volume 13, Numbers 3/4 February 2008 The application of FAST-NMR for the identification of novel drug discovery targets Robert Powers, Kelly A. Mercier and Jennifer C. Copeland for a drug discovery effort. The completion of the human genome project is spurring tremen- dous progress

  4. Anticoagulation Drug Therapy: A Review

    E-Print Network [OSTI]

    Harter, Katherine; Levine, Michael; Henderson, Sean O.

    2015-01-01

    et al. Anticoagulation Drug Therapy: A Review 15. NishijimaRandomized antiplatelet drugs. In: Goodman & Gilman’s The2008;24:2757-65. Cardiovasc Drugs. 2006;6:265-85. 34. Nordt

  5. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01

    alcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.outcomes in an indicated drug prevention program for high-

  6. Non-traditional platinum compounds for improved cellular accumulation and tumor targeting

    E-Print Network [OSTI]

    Lovejoy, Katherine Summer, 1981-

    2009-01-01

    Chapter 1. Introduction to Non-Traditional Platinum Compounds for Improved Uptake, Oral Bioavailability, and Tumor Targeting The path to more potent platinum anticancer drugs with fewer side effects lies in the exploration ...

  7. A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy

    E-Print Network [OSTI]

    Valencia, Pedro M. (Pedro Miguel)

    2013-01-01

    The use of nanotechnology to engineer drug delivery vehicles comprised of controlled release polymers with targeting molecules has the potential to revolutionize cancer therapy, among other diseases. Although a myriad of ...

  8. A systems approach to uncovering the adaptive response of cancer to targeted therapies

    E-Print Network [OSTI]

    Randall, Adrian Joseph

    2012-01-01

    Tyrosine kinase inhibitors have significant promise in the fight to develop agents that can target cancer in a tumor-specific manner. A number of drugs have been and are currently in development to inhibit specific kinases ...

  9. The design and characterization of a microcalorimeter to aid drug discovery

    E-Print Network [OSTI]

    McEuen, Scott Jacob

    2008-01-01

    This thesis describes the design and characterization of a microcalorimeter used to aid drug discovery. There are four key functional requirements for the device: (1.) 8.4 [mu]J energy resolution, (2.) 20 [mu]L reactant ...

  10. Understanding and Targeting Lipid Metabolism of Mycobacterium tuberculosis 

    E-Print Network [OSTI]

    Liu, Zhen

    2013-12-09

    ; Fanny Boissier et al., 2006). This, coupled with the distinct biological functions of CMASs, suggests that CMASs are applicable as targets of a single drug. Indeed, we(Daniel Barkan et al., 2009) and Lionel Mourey et al.(Julien Vaubourgei et al., 2009...

  11. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    as we try to develop drugs that might work on specific subunits and therefore help fight or cure some of these neurological diseases and conditions," said principal...

  12. Assessment of ion-selective optical nanosensors for drug screening applications

    E-Print Network [OSTI]

    Yun, Hannah

    2007-01-01

    Ion channels represent an important category of drug targets. They play a significant role in numerous physiological functions, from membrane excitation and signaling to fluid absorption and secretion. An ion-channel assay ...

  13. Functionalized Zirconium Phosphate Nano Platelets - From Surface Design to Drug Delivery 

    E-Print Network [OSTI]

    Mukherjee, Atashi

    2014-05-30

    the intended target or compartment. This dissertation will focus on the analytical characterization of zirconium phosphate (ZrP) in both alpha and theta phases as a drug delivery matrix utilizing multiple unique and novel analytical techniques. In the first...

  14. Hash-based Multivariate Public Key Cryptosystems

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    Hash-based Multivariate Public Key Cryptosystems WANG Hou-Zhen and ZHANG Huan-Guo The Key for the traditional multivariate public key cryp- tosystems. For example, the signature scheme SFLASH was broken. at ASIACRYPTO'09. Most multivariate schemes known so far are insecure, except maybe the sigature schemes UOV

  15. Preliminary safety assessment for an IFE target fabrication facility

    SciTech Connect (OSTI)

    Latkowski, J F; Reyes, S; Besenbruch, G E; Goodin, D T

    2000-10-13

    We estimate possible ranges of tritium inventories for an inertial fusion energy (IFE) target fabrication facility producing various types of targets and using various production technologies. Target fill is the key subtask in determining the overall tritium inventory for the plant. By segmenting the inventory into multiple, parallel production lines--each with its own fill canister--and including an expansion tank to limit releases, we are able to ensure that a target fabrication facility would meet the accident dose goals of 10 mSv (1 rem) set forth in the Department of Energy's Fusion Safety Standards. For indirect-drive targets, we calculate release fractions for elements from lithium to bismuth and show that nearly all elements meet the dose goal. Our work suggests directions for future R&D that will help reduce total tritium inventories and increase the flexibility of target fabrication facilities.

  16. Drug Information Chart Notes Drug ad (intrinsic bias)

    E-Print Network [OSTI]

    Fletcher, Robin

    Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company Dosage Same or different? A drug in a different dosage can be used for a different therapy. Precautions Check for pregnancy A complete book on drugs in pregnancy and lactation in bibliography. (unbiased

  17. Neutronic Characterization of the Megapie Target

    E-Print Network [OSTI]

    Stefano Panebianco; Olivier Bringer; Pavel Bokov; Sebastien Chabod; Frederic Chartier; Emmeric Dupont; Diane Dore; Xavier Ledoux; Alain Letourneau; Ludovic Oriol; Aurelien Prevost; Danas Ridikas; Jean-Christian Toussaint

    2007-10-31

    The MEGAPIE project is one of the key experiments towards the feasibility of Accelerator Driven Systems. On-line operation and post-irradiation analysis will provide the scientific community with unique data on the behavior of a liquid spallation target under realistic irradiation conditions. A good neutronics performance of such a target is of primary importance towards an intense neutron source, where an extended liquid metal loop requires some dedicated verifications related to the delayed neutron activity of the irradiated PbBi. In this paper we report on the experimental characterization of the MEGAPIE neutronics in terms of the prompt neutron (PN) flux inside the target and the delayed neutron (DN) flux on the top of it. For the PN measurements, a complex detector, made of 8 microscopic fission chambers, has been built and installed in the central part of the target to measure the absolute neutron flux and its spatial distribution. Moreover, integral information on the neutron energy distribution as a function of the position along the beam axis could be extracted, providing integral constraints on the neutron production models implemented in transport codes such as MCNPX. For the DN measurement, we used a standard 3He counter and we acquired data during the start-up phase of the target irradiation in order to take sufficient statistics at variable beam power. Experimental results obtained on the PN flux characteristics and their comparison with MCNPX simulations are presented, together with a preliminary analysis of the DN decay time spectrum.

  18. IBMS BoneKEy. 2009 April;6(4):132-149 http://www.bonekey-ibms.org/cgi/content/full/ibmske;6/4/132

    E-Print Network [OSTI]

    IBMS BoneKEy. 2009 April;6(4):132-149 http://www.bonekey-ibms.org/cgi/content/full/ibmske;6 and osteoporosis, yet uniquely ­ without targeting the resident fat or bone cell. IBMS BoneKEy. 2009 April;6 with diabetes are afflicted with type 2 disease (5-7). Visceral adiposity and #12;IBMS BoneKEy. 2009 April;6

  19. An Implantable Bio-Micro-system for Drug Monitoring

    E-Print Network [OSTI]

    De Micheli, Giovanni

    An Implantable Bio-Micro-system for Drug Monitoring Sara Ghoreishizadeh, Enver G. Kilinc, Camilla of the implantable monitoring system for long- term duration has many challenges. First, a multi-target biosen- sor coil; (ii) A power manage- ment IC dealing with the energy source of the implantable microsystem

  20. Drug Delivery DOI: 10.1002/anie.200802260

    E-Print Network [OSTI]

    Zare, Richard N.

    ,[2] which were genetically engineered to universally express luciferase, provides a rapid readout of the body by using a modified b-actin promoter.[4] As the majority of luciferin is cleared from the body nanoparticle could be engineered to target different cells.[3,6] PLA is an Food and Drug Administration (FDA

  1. DRUG DISCOVERY AT PURDUE 2013-14

    E-Print Network [OSTI]

    Pittendrigh, Barry

    DRUG DISCOVERY AT PURDUE 2013-14 #12;PURDUE UNIVERSITY DRUG DISCOVERY 2 #12;PURDUE UNIVERSITY DRUG DISCOVERY 3 #12;PURDUE UNIVERSITY DRUG DISCOVERY 4 TABLE OF CONTENTS INTRODUCTION ..................................................................................................p. 8 ALPHABETICAL LIST OF DRUG DISCOVERY RESEARCHERS

  2. Cooled particle accelerator target

    DOE Patents [OSTI]

    Degtiarenko, Pavel V.

    2005-06-14

    A novel particle beam target comprising: a rotating target disc mounted on a retainer and thermally coupled to a first array of spaced-apart parallel plate fins that extend radially inwardly from the retainer and mesh without physical contact with a second array of spaced-apart parallel plate fins that extend radially outwardly from and are thermally coupled to a cooling mechanism capable of removing heat from said second array of spaced-apart fins and located within the first array of spaced-apart parallel fins. Radiant thermal exchange between the two arrays of parallel plate fins provides removal of heat from the rotating disc. A method of cooling the rotating target is also described.

  3. Targeted polypeptide degradation

    DOE Patents [OSTI]

    Church, George M. (Brookline, MA); Janse, Daniel M. (Brookline, MA)

    2008-05-13

    This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

  4. Foam encapsulated targets

    DOE Patents [OSTI]

    Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

    1983-01-01

    Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

  5. Key Elements of and Materials Performance Targets for Highly Insulating Window Frames

    E-Print Network [OSTI]

    Gustavsen, Arild

    2012-01-01

    can calculate radiation heat transfer using view factors orcould reduce radiation heat transfer in frame cavities. Wethe radiation portion of the surface heat transfer is

  6. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases...

  7. Wind Vision: Analysis Highlights and Key Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Highlights and Key Results Eric Lantz (NREL) Ryan Wiser (LBNL) July 15, 2015 2 | Wind and Water Power Technologies Office eere.energy.gov Presentation Overview Wind...

  8. Monroe County Extension Services Key West Office

    E-Print Network [OSTI]

    Hill, Jeffrey E.

    potable water is pumped to the Keys from the mainland through a 130-mile long transmission line irrigation and fertilizer, and are more

  9. Unifying classical and quantum key distillation

    E-Print Network [OSTI]

    Matthias Christandl; Artur Ekert; Michal Horodecki; Pawel Horodecki; Jonathan Oppenheim; Renato Renner

    2007-02-28

    Assume that two distant parties, Alice and Bob, as well as an adversary, Eve, have access to (quantum) systems prepared jointly according to a tripartite state. In addition, Alice and Bob can use local operations and authenticated public classical communication. Their goal is to establish a key which is unknown to Eve. We initiate the study of this scenario as a unification of two standard scenarios: (i) key distillation (agreement) from classical correlations and (ii) key distillation from pure tripartite quantum states. Firstly, we obtain generalisations of fundamental results related to scenarios (i) and (ii), including upper bounds on the key rate. Moreover, based on an embedding of classical distributions into quantum states, we are able to find new connections between protocols and quantities in the standard scenarios (i) and (ii). Secondly, we study specific properties of key distillation protocols. In particular, we show that every protocol that makes use of pre-shared key can be transformed into an equally efficient protocol which needs no pre-shared key. This result is of practical significance as it applies to quantum key distribution (QKD) protocols, but it also implies that the key rate cannot be locked with information on Eve's side. Finally, we exhibit an arbitrarily large separation between the key rate in the standard setting where Eve is equipped with quantum memory and the key rate in a setting where Eve is only given classical memory. This shows that assumptions on the nature of Eve's memory are important in order to determine the correct security threshold in QKD.

  10. Targeted Advertising on the Handset: Privacy and Security Challenges

    E-Print Network [OSTI]

    Henderson, Tristan

    Targeted Advertising on the Handset: Privacy and Security Challenges Hamed Haddadi, Pan Hui, Tristan Henderson and Ian Brown Abstract Online advertising is currently a rich source of revenue for many for personalised and localised advertising. A key benefit of using mobile phones is to take advantage

  11. On multivariate signatureonly public key cryptosystems

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    On multivariate signature­only public key cryptosystems Nicolas T. Courtois 1,2 courtois we argument that the problem has many natural solutions within the framework of the multivariate cryptography. First of all it seems that virtually any non­injective multivariate public key is inherently

  12. Deniable Internet Key Exchange Andrew C. Yao

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    Deniable Internet Key Exchange Andrew C. Yao Frances F. Yao Yunlei Zhao§ Bin Zhu¶ Abstract In this work, we develop a family of protocols for deniable Internet Key-Exchange (IKE) with the following of privacy protection (especially for E-commerce over Internet), this work is naturally of practical interest

  13. Solvent recovery targeting

    SciTech Connect (OSTI)

    Ahmad, B.S.; Barton, P.I.

    1999-02-01

    One of the environmental challenges faced by the pharmaceutical and specialty chemical industries is the widespread use of organic solvents. With a solvent-based chemistry, the solvent necessarily has to be separated from the product. Chemical species in waste-solvent streams typically form multicomponent azeotropic mixtures, and this often complicates separation and, hence, recovery of solvents. A design approach is presented whereby process modifications proposed by the engineer to reduce the formation of waste-solvent streams can be evaluated systematically. This approach, called solvent recovery targeting, exploits a recently developed algorithm for elucidating the separation alternatives achievable when applying batch distillation to homogeneous multicomponent mixtures. The approach places the composition of the waste-solvent mixture correctly in the relevant residue curve map and computes the maximum amount of pure material that can be recovered via batch distillation. Solvent recovery targeting is applied to two case studies derived from real industrial processes.

  14. Target | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page| Open Energy Information Serbia-Enhancing CapacityVectren)ModelTalbotts Ltd JumpJumpInformationTaosTarget

  15. Apparatus for forming targets

    DOE Patents [OSTI]

    Woerner, Robert L. (Livermore, CA)

    1980-01-01

    Apparatus and method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

  16. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26

    Stability 0 20 40 60 80 100 25 10 5 1 0.5 size? r 0 (?m) Fr action absor b ed in hum an (% ) Peff =5.0 Peff =3.0 Peff =1.0 Peff =0.5 Peff =0.1 Solubility? Cs = 1.0 (?g/ml) Effect of micronization on intestinal absorption of poorly soluble drugs Peff... ?? permeability to human intestine? (cm/sec x 10 -4 ) 8 Effect of Solubility on intestinal absorption of poorly soluble drugs Cs (?g/ml) 0 5 10 15 50 Fr action absor b ed in hum an (% ) 0 20 40 60 80 100 Peff =5.0 Peff =3.0 Peff =1.0 Peff =0.5 Peff =0.1 r 0 = 1...

  17. Captured key electrical safety lockout system

    DOE Patents [OSTI]

    Darimont, Daniel E. (Aurora, IL)

    1995-01-01

    A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member's second position corresponds to the preselected position at which the key can be removed from and inserted into the lock.

  18. Captured key electrical safety lockout system

    SciTech Connect (OSTI)

    Darimont, D.E.

    1995-10-31

    A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member`s second position corresponds to the preselected position at which the key can be removed from and inserted into the lock. 7 figs.

  19. Key Renewable Energy Opportunities for Oklahoma Tribes

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested Parties - WAPA Public CommentInverted253.16582104) Kenmore:Key2: ProjectKeyKEY

  20. BACK TO BASICS: YOUR KEYS TO SAFE

    E-Print Network [OSTI]

    Kirschner, Denise

    BACK TO BASICS: YOUR KEYS TO SAFE DRIVING FINE-TUNE THE FUNDAMENTALS DRIVE SAFELY WORK WEEK: FRIDAY an occasional refresher. In fact, most company fleet safety programs emphasize basic skills and defensive

  1. Civil Engineering BEng (Hons) Key details

    E-Print Network [OSTI]

    Painter, Kevin

    Civil Engineering BEng (Hons) Key details Duration: Full-time: 4 years (BEng Hons) Delivery type engineering disciplines of Structures, Geotechnics, Water Engineering and Transportation Engineering civil or structural engineers. After graduation, students are equipped to work for consultants

  2. Extracting secret keys from integrated circuits

    E-Print Network [OSTI]

    Lim, Daihyun, 1976-

    2004-01-01

    Modern cryptographic protocols are based on the premise that only authorized participants can obtain secret keys and access to information systems. However, various kinds of tampering methods have been devised to extract ...

  3. Homing Endonuclease Target Site Specificity Defined by Sequential Enrichment and Next-Generation

    E-Print Network [OSTI]

    Monnat, Ray

    151 Chapter 12 Homing Endonuclease Target Site Specificity Defined by Sequential Enrichment and Next-Generation Sequencing of Highly Complex Target Site Libraries Hui Li and Raymond J. Monnat Jr- get site libraries and high-throughput DNA sequencing. Key words Homing endonuclease, Cleavage

  4. Simulation of High-Power Mercury Jet Targets for Neutrino Factory and Muon

    E-Print Network [OSTI]

    McDonald, Kirk

    Simulation of High-Power Mercury Jet Targets for Neutrino Factory and Muon Collider R. Samulyak,1 interacting with proton pulses in 15-20T magnetic field is a key element of high-power target systems · Proof rarefaction waves · Cavities can form on inter-particle size scales · Present work focuses of pure hydro

  5. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES OctoberEvanServices »First ObservationFast(ER1) TargetRL -

  6. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES OctoberEvanServices »First ObservationFast(ER1) TargetRL - -

  7. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES OctoberEvanServices »First ObservationFast(ER1) TargetRL - -

  8. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES OctoberEvanServices »First ObservationFast(ER1) TargetRL - - -

  9. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you not find whatGasEnergyfeature photoTheory05 Target 1 Flight Path90L2

  10. Target: Subpoena (2010-SE-2001)

    Broader source: Energy.gov [DOE]

    DOE issued a Subpoena for Information and Production of Documents to Target Corporation requesting information regarding the compliance of various torchieres Target has distributed in commerce in the U.S.

  11. Target detection portal

    DOE Patents [OSTI]

    Linker, Kevin L. (Albuquerque, NM); Brusseau, Charles A. (Tijeras, NM)

    2002-01-01

    A portal apparatus for screening persons or objects for the presence of trace amounts of target substances such as explosives, narcotics, radioactive materials, and certain chemical materials. The portal apparatus can have a one-sided exhaust for an exhaust stream, an interior wall configuration with a concave-shape across a horizontal cross-section for each of two facing sides to result in improved airflow and reduced washout relative to a configuration with substantially flat parallel sides; air curtains to reduce washout; ionizing sprays to collect particles bound by static forces, as well as gas jet nozzles to dislodge particles bound by adhesion to the screened person or object. The portal apparatus can be included in a detection system with a preconcentrator and a detector.

  12. PDFs for nuclear targets

    E-Print Network [OSTI]

    Karol Kovarik

    2010-06-25

    Understanding nuclear effects in parton distribution functions (PDF) is an essential component needed to determine the strange and anti-strange quark contributions in the proton. In addition Nuclear Parton Distribution Functions (NPDF) are critically important for any collider experiment with nuclei (e.g. RHIC, ALICE). Here two next-to-leading order chi^2-analyses of NPDF are presented. The first uses neutral current charged-lepton Deeply Inelastic Scattering (DIS) and Drell-Yan data for several nuclear targets and the second uses neutrino-nucleon DIS data. We compare the nuclear corrections factors (F_2^Fe/F_2^D) for the charged-lepton data with other results from the literature. In particular, we compare and contrast fits based upon the charged-lepton DIS data with those using neutrino-nucleon DIS data.

  13. Target Diagnostics Supports NIF's Path to Ignition

    SciTech Connect (OSTI)

    Shelton, R

    2011-12-07

    The physics requirements derived from the National Ignition Facility (NIF) experimental campaigns are leading to a wide variety of target diagnostics. Software development for the control and analysis of these diagnostics is included in the NIF Integrated Computer Control System, Diagnostic Control System and Data Visualization. These projects implement the configuration, controls, data analysis and visual representation of most of these diagnostics. To date, over 40 target diagnostics have been developed to support NIF experiments. In 2011 diagnostics were developed or enhanced to measure Ignition performance in a high neutron yield environment. Performance is optimized around four key variables: Adiabat (a) which is the strength and timing of four shocks delivered to the target, Velocity (V) of the imploding target, Mix (M) is the uniformity of the burn, and the Shape (S) of the imploding Deuterium Tritium (DT) hot spot. The diagnostics used to measure each of these parameters is shown in figure 1. Adiabat is measured using the Velocity Interferometer System for Any Reflector (VISAR) diagnostic consisting of three streak cameras. To provide for more accurate adiabat measurements the VISAR streak cameras were enhanced in FY11 with a ten comb fiducial signal controller to allow for post shot correction of the streak camera sweep non-linearity. Mix is measured by the Neutron Time of Flight (NTOF) and Radiochemical Analysis of Gaseous Samples (RAGS) diagnostics. To accommodate high neutron yield shots, NTOF diagnostic controls are being modified to use Mach Zehnder interferometer signals to allow the digitizers to be moved from near the target chamber to the neutron shielded diagnostic mezzanine. In December 2011 the first phase of RAGS diagnostic commissioning will be completed. This diagnostic will analyze the tracers that are added to NIF target capsules that undergo nuclear reactions during the shot. These gases are collected and purified for nuclear counting by the RAGS system. Three new instrument controllers were developed and commissioned to support this diagnostic. A residual-gas analyzer (RGA) instrument measures the gas content at various points in the system. The Digital Gamma Spectrometer instrument measures the radiological spectrum of the decaying gas isotopes. A final instrument controller was developed to interface to a PLC based Gas collection system. In order to support the implosion velocity measurements an additional Gated X-ray Detector (GXD) diagnostic was tested and commissioned. This third GXD views the target through a slit contained in its snout and allows the other GXD diagnostics to be used for measuring the shape on the same shot. In order to measure the implosion shape in a high neutron environment, Actide Readout In A Neutron Environment (ARIANE) and Neutron Imaging (NI) diagnostics were commissioned. The controls for ARIANE, a fixed port gated x-ray imager, contain a neutron shielded camera and micro channel plate pulser with its neutron sensitive electronics located in the diagnostic mezzanine. The NI diagnostic is composed of two Spectral Instruments SI-1000 cameras located 20M from the target and provides neutron images of the DT hot spot for high yield shots. The development and commissioning of these new or enhanced diagnostics in FY11 have provided meaningful insight that facilitates the optimization of the four key Ignition variables. In FY12 they will be adding three new diagnostics and enhancing four existing diagnostics in support of the continuing optimization series of campaigns.

  14. Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance

    E-Print Network [OSTI]

    Wu, Alan HB

    2011-01-01

    this article as: Wu: Drug metabolizing enzyme activitiesgenetic variances for drug of clinical pharmacogenomicPROTEOMICS Open Access Drug metabolizing enzyme activities

  15. BACK TO BASICS: YOUR KEYS TO SAFE

    E-Print Network [OSTI]

    Kirschner, Denise

    BACK TO BASICS: YOUR KEYS TO SAFE DRIVING BUCKLE UP! Seat belts should never have time off DRIVE the back seat to the front seat.4 ·The back is the best place for pets. According to AAA, similar. Never place the shoulder portion under your arm or behind your back! ·Drivers should sit with at least

  16. Mechanical Engineering BEng / BEng (Hons) Key details

    E-Print Network [OSTI]

    Painter, Kevin

    Mechanical engineers play key roles in all industrial sectors, from aerospace and oil and gas, through food for Mechanical Engineering graduates in many sectors, including power production, oil and petrochemicals, manufacturing, power plant, medical engineering and many others l Whatever your final career path, developing

  17. Fashion Marketing & Retailing BA (Hons) Key details

    E-Print Network [OSTI]

    Painter, Kevin

    Fashion Marketing & Retailing BA (Hons) Key details Duration: Full-time: 3 years (BA) / 4 years (BA Hons) Delivery type: Day Intake date: September Fees: 54000 AED per year Overview Our Fashion Marketing and Retailing programme confidently prepares students for a career within the marketing and retailing industry

  18. Key Management Challenges in Smart Grid

    SciTech Connect (OSTI)

    Sheldon, Frederick T; Duren, Mike

    2012-01-01

    Agenda Awarded in February 2011 Team of industry and research organizations Project Objectives Address difficult issues Complexity Diversity of systems Scale Longevity of solution Participate in standards efforts and working groups Develop innovative key management solutions Modeling and simulation ORNL Cyber Security Econometric Enterprise System Demonstrate effectiveness of solution Demonstrate scalability

  19. Organisational Change -Key Steps LocalCollege/

    E-Print Network [OSTI]

    Botea, Adi

    Resources Division START Version 1.0 X:\\Employment Strategies\\Workplace Change & Innovation\\Change Management Frameworks\\Change Management - Key Steps 021111.vsd FINISH NOTES: * For information on formal vs informal change refer to the managing change clause in the ANU Enterprise Agreement and the managing change policy

  20. Chemical Engineering BEng (Hons) Key details

    E-Print Network [OSTI]

    Painter, Kevin

    Chemical Engineering BEng (Hons) Key details Duration: Full-time: 3 years (BEng) / 4 years (BEng Hons) Delivery type: Day Intake date: September Fees: 58000 AED per year Overview Chemical engineering successful and thriving types of business in the world. Chemical engineers play a vital role in achieving

  1. Management strategies for endangered Florida Key deer 

    E-Print Network [OSTI]

    Peterson, Markus Nils

    2004-09-30

    species. These data were used to address my study objectives. I found the most commonly cited FSR (2.67:1, male:female) for Florida Key deer to be inaccurate. A male biased FSR of 1.45:1 was more probable. Modified drop and drive nets were appropriate...

  2. Psychology with Management BSc (Hons) Key details

    E-Print Network [OSTI]

    Painter, Kevin

    Psychology with Management BSc (Hons) Key details Duration: Full-time: 4 years Delivery type: Day% Psychology with 25% Business and Management modules. Psychology modules cover a range of core approaches to psychology as well as research design and analysis and applied specialist topics. The curriculum is based

  3. Roadmap for selected key measurements of LHCb

    E-Print Network [OSTI]

    The LHCb Collaboration; B. Adeva; M. Adinolfi; A. Affolder; Z. Ajaltouni; J. Albrecht; F. Alessio; M. Alexander; P. Alvarez Cartelle; A. A. Alves Jr; S. Amato; Y. Amhis; J. Amoraal; J. Anderson; O. Aquines Gutierrez; L. Arrabito; M. Artuso; E. Aslanides; G. Auriemma; S. Bachmann; Y. Bagaturia; D. S. Bailey; V. Balagura; W. Baldini; MdC. Barandela Pazos; R. J. Barlow; S. Barsuk; A. Bates; C. Bauer; Th. Bauer; A. Bay; I. Bediaga; K. Belous; I. Belyaev; M. Benayoun; G. Bencivenni; R. Bernet; M. -O. Bettler; A. Bizzeti; T. Blake; F. Blanc; C. Blanks; J. Blouw; S. Blusk; A. Bobrov; V. Bocci; A. Bondar; N. Bondar; W. Bonivento; S. Borghi; A. Borgia; E. Bos; T. J. V. Bowcock; C. Bozzi; J. Bressieux; S. Brisbane; M. Britsch; N. H. Brook; H. Brown; A. Büchler-Germann; J. Buytaert; J. -P. Cachemiche; S. Cadeddu; J. M. Caicedo Carvajal; O. Callot; M. Calvi; M. Calvo Gomez; A. Camboni; W. Cameron; P. Campana; A. Carbone; G. Carboni; A. Cardini; L. Carson; K. Carvalho Akiba; G. Casse; M. Cattaneo; M. Charles; Ph. Charpentier; A. Chlopik; P. Ciambrone; X. Cid Vidal; P. J. Clark; P. E. L. Clarke; M. Clemencic; H. V. Cliff; J. Closier; C. Coca; V. Coco; J. Cogan; P. Collins; F. Constantin; G. Conti; A. Contu; G. Corti; G. A. Cowan; B. D'Almagne; C. D'Ambrosio; D. G. d'Enterria; W. Da Silva; P. David; I. De Bonis; S. De Capua; M. De Cian; F. De Lorenzi; J. M. De Miranda; L. De Paula; P. De Simone; H. De Vries; D. Decamp; H. Degaudenzi; M. Deissenroth; L. Del Buono; C. Deplano; O. Deschamps; F. Dettori; J. Dickens; H. Dijkstra; M. Dima; S. Donleavy; A. C. dos Reis; A. Dovbnya; T. Du Pree; P. -Y. Duval; L. Dwyer; R. Dzhelyadin; C. Eames; S. Easo; U. Egede; V. Egorychev; F. Eisele; S. Eisenhardt; L. Eklund; D. Esperante Pereira; L. Estève; S. Eydelman; E. Fanchini; C. Färber; G. Fardell; C. Farinelli; S. Farry; V. Fave; V. Fernandez Albor; M. Ferro-Luzzi; S. Filippov; C. Fitzpatrick; F. Fontanelli; R. Forty; M. Frank; C. Frei; M. Frosini; J. L. Fungueirino Pazos; S. Furcas; A. Gallas Torreira; D. Galli; M. Gandelman; Y. Gao; J-C. Garnier; L. Garrido; C. Gaspar; N. Gauvin; M. Gersabeck; T. Gershon; Ph. Ghez; V. Gibson; Yu. Gilitsky; V. V. Gligorov; C. Göbel; D. Golubkov; A. Golutvin; A. Gomes; M. Grabalosa Gándara; R. Graciani Diaz; L. A. Granado Cardoso; E. Graugés; G. Graziani; A. Grecu; G. Guerrer; E. Gushchin; Yu. Guz; Z. Guzik; T. Gys; F. Hachon; G. Haefeli; S. C. Haines; T. Hampson; S. Hansmann-Menzemer; R. Harji; N. Harnew; P. F. Harrison; J. He; K. Hennessy; P. Henrard; J. A. Hernando Morata; A. Hicheur; E. Hicks; W. Hofmann; K. Holubyev; P. Hopchev; W. Hulsbergen; P. Hunt; T. Huse; R. S. Huston; D. Hutchcroft; V. Iakovenko; C. Iglesias Escudero; J. Imong; R. Jacobsson; M. Jahjah Hussein; E. Jans; F. Jansen; P. Jaton; B. Jean-Marie; M. John; C. R. Jones; B. Jost; F. Kapusta; T. M. Karbach; J. Keaveney; U. Kerzel; T. Ketel; A. Keune; S. Khalil; B. Khanji; Y. M. Kim; M. Knecht; J. Knopf; S. Koblitz; A. Konoplyannikov; P. Koppenburg; I. Korolko; A. Kozlinskiy; M. Krasowski; L. Kravchuk; P. Krokovny; K. Kruzelecki; M. Kucharczyk; I. Kudryashov; T. Kvaratskheliya; D. Lacarrere; A. Lai; R. W. Lambert; G. Lanfranchi; C. Langenbruch; T. Latham; R. Le Gac; R. Lefevre; A. Leflat; J. Lefrançois; O. Leroy; K. Lessnoff; L. Li; Y. Y. Li; J. Libby; M. Lieng; R. Lindner; S. Lindsey; C. Linn; B. Liu; G. Liu; J. H. Lopes; E. Lopez Asamar; J. Luisier; F. Machefert; I. Machikhiliyan; F. Maciuc; O. Maev; J. Magnin; A. Maier; R. M. D. Mamunur; G. Manca; G. Mancinelli; N. Mangiafave; U. Marconi; F. Marin; J. Marks; G. Martellotti; A. Martens; L. Martin; D. Martinez Santos; Z. Mathe; C. Matteuzzi; V. Matveev; A. Mazurov; G. McGregor; B. Mcharek; C. Mclean; R. McNulty; M. Merk; J. Merkel; M. Merkin; R. Messi; F. C. D. Metlica; J. Michalowski; S. Miglioranzi; M. -N. Minard; S. Monteil; D. Moran; J. V. Morris; R. Mountain; I. Mous; F. Muheim; R. Muresan; F. Murtas; B. Muryn; M. Musy; J. Mylroie-Smith; P. Naik; T. Nakada; R. Nandakumar; J. Nardulli; Z. Natkaniec; M. Nedos; M. Needham; N. Neufeld; L. Nicolas; S. Nies; V. Niess; N. Nikitin; A. Noor; A. Oblakowska-Mucha; V. Obraztsov; S. Oggero; O. Okhrimenko; R. Oldeman; M. Orlandea; A. Ostankov; J. Palacios; M. Palutan; J. Panman; A. Papadelis; A. Papanestis; M. Pappagallo; C. Parkes; G. Passaleva; G. D. Patel; M. Patel; S. K. Paterson; G. N. Patrick; E. Pauna; C. Pauna; C. Pavel; A. Pazos Alvarez; A. Pellegrino; G. Penso; M. Pepe Altarelli; S. Perazzini; D. L. Perego; A. Pérez-Calero Yzquierdo; E. Perez Trigo; P. Perret; G. Pessina; A. Petrella; A. Petrolini; B. Pietrzyk; D. Pinci; S. Playfer; M. Plo Casasus; G. Polok; A. Poluektov; E. Polycarpo; D. Popov; B. Popovici; S. Poss; C. Potterat; A. Powell; S. Pozzi; V. Pugatch; A. Puig Navarro; W. Qian; J. H. Rademacker; B. Rakotomiaramanana; I. Raniuk; G. Raven; S. Redford; W. Reece

    2010-11-23

    Six of the key physics measurements that will be made by the LHCb experiment, concerning CP asymmetries and rare B decays, are discussed in detail. The "road map" towards the precision measurements is presented, including the use of control channels and other techniques to understand the performance of the detector with the first data from the LHC.

  4. Business Management BA / MA (Hons) Key details

    E-Print Network [OSTI]

    Painter, Kevin

    Business Management BA / MA (Hons) Key details Duration: Full-time: 3 years (BA) / 4 years (MSc Management degree programme follows a number of guiding principles that mirror the values of managers of leading organisations and reflect current business management thinking. In the first two years of all

  5. Vermont's Changing Forests Key Findings on the

    E-Print Network [OSTI]

    Keeton, William S.

    1 Vermont's Changing Forests Key Findings on the Health of Forested Ecosystems from the Vermont Members Anne Archie, USDA Forest Service Douglas Lantagne, University of Vermont Ed O'Leary, Vermont, USDA Farm Service Agency Charles Scott, USDA Forest Service Steven Sinclair, Vermont Agency of Natural

  6. Automotive Engineering BEng (Hons) Key details

    E-Print Network [OSTI]

    Painter, Kevin

    Automotive Engineering BEng (Hons) Key details Duration: Full-time: 3 years (BEng) / 4 years (BEng programme, but allows students in the later years to specialise in subjects relating to automotive technology. Automotive engineering continues to be a major employer of professional engineers, owing

  7. CAREER RESOURCES Canadian Key Business Directory

    E-Print Network [OSTI]

    Thompson, Michael

    CAREER RESOURCES BOOKS Canadian Key Business Directory - Includes the largest companies in Canada companies - Search by name, geography, SIC code and more! - Online version available through library: http://www.jobsetc.gc.ca/eng/ - Training, career and worker information - Career Exploration resources

  8. NCLC November 1999 Cem Kaner Page 1 UCITA: Key Consumer IssuesUCITA: Key Consumer Issues

    E-Print Network [OSTI]

    NCLC November 1999 Cem Kaner Page 1 UCITA: Key Consumer IssuesUCITA: Key Consumer Issues Cem Kaner, J.D., Ph.D., ASQ-CQE November 1999 Contact Information: kaner@kaner.com www.kaner.com (testing November 1999 Cem Kaner Page 2 UCITA? Huh?UCITA? Huh? · Uniform Computer Information Transactions Act

  9. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, Douglas N. (Knoxville, TN)

    1996-01-01

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

  10. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, D.N.

    1996-01-09

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

  11. Analysis ? Targeting Zero Net Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Analysis - Targeting Zero Net Energy 2014 Building Technologies Office Peer Review Scott Horowitz, scott.horowitz@nrel.gov NREL Project Summary Timeline: Start date: 2010 Planned...

  12. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  13. Chemical and Petroleum Engineering Key and Lab Space Agreement

    E-Print Network [OSTI]

    Chemical and Petroleum Engineering Key and Lab Space Agreement Key Holder Information Last Name and Petroleum Engineering remain the property of the Department. I agree to pay a deposit for the keys

  14. Target R & D LBNE Collaboration Meeting

    E-Print Network [OSTI]

    McDonald, Kirk

    are not planning on having an integrated target / horn 1 · Will of course change if appropriate · The R&D effort Hall utilities) David Hickson (Target Hall utilities) Pat Hurh (Target technical components Tariq (Target pile, remote handling) Karl Williams (Target Hall utilities) Tim Wyman (Target Hall

  15. A probabilistic approach to microRNA-target binding

    SciTech Connect (OSTI)

    Ogul, Hasan; Umu, Sinan U.; Bioinformatics Program, Informatics Institute, Middle East Technical University, Cankaya TR-06800, Ankara ; Tuncel, Y. Yener; Akkaya, Mahinur S.

    2011-09-16

    Highlights: {yields} A new probabilistic model is introduced for microRNA-target binding. {yields} The new model significantly outperforms RNAHybrid and miRTif. {yields} The experiments can unveil the effects of the type and directions of distinct base pairings. -- Abstract: Elucidation of microRNA activity is a crucial step in understanding gene regulation. One key problem in this effort is how to model the pairwise interactions of microRNAs with their targets. As this interaction is strongly mediated by their sequences, it is desired to set-up a probabilistic model to explain the binding preferences between a microRNA sequence and the sequence of a putative target. To this end, we introduce a new model of microRNA-target binding, which transforms an aligned duplex to a new sequence and defines the likelihood of this sequence using a Variable Length Markov Chain. It offers a complementary representation of microRNA-mRNA pairs for microRNA target prediction tools or other probabilistic frameworks of integrative gene regulation analysis. The performance of present model is evaluated by its ability to predict microRNA-target mRNA interaction given a mature microRNA sequence and a putative mRNA binding site. In regard to classification accuracy, it outperforms two recent methods based on thermodynamic stability and sequence complementarity. The experiments can also unveil the effects of base pairing types and non-seed region in duplex formation.

  16. Quantum Hacking on Continuous-Variable Quantum Key Distribution System using a Wavelength Attack

    E-Print Network [OSTI]

    Jing-Zheng Huang; Christian Weedbrook; Zhen-Qiang Yin; Shuang Wang; Hong-Wei Li; Wei Chen; Guang-Can Guo; Zheng-Fu Han

    2013-07-24

    The security proofs of continuous-variable quantum key distribution are based on the assumptions that the eavesdropper can neither act on the local oscillator nor control Bob's beam splitter. These assumptions may be invalid in practice due to potential imperfections in the implementations of such protocols. In this paper, we consider the problem of transmitting the local oscillator in a public channel and propose a wavelength attack which can allow the eavesdropper to control the intensity transmission of Bob's beam splitter by switching the wavelength of the input light. Specifically we target continuous-variable quantum key distribution systems that use the heterodyne detection protocol using either direct or reverse reconciliation. Our attack is proved to be feasible and renders all of the final key shared between the legitimate parties insecure, even if they have monitored the intensity of the local oscillator. To prevent our attack on commercial systems, a simple wavelength filter should be added before performing the monitoring detection.

  17. Targeted Specular Photons Michelle Laprade

    E-Print Network [OSTI]

    Montréal, Université de

    Targeted Specular Photons Michelle Laprade Département d'Informatique et de Recherche in the resulting image which are not captured using traditional photon map- ping algorithms. This method uses a separate group of photons ­ targeted specular photons ­ which are shot specifically towards

  18. Identification of Key Barriers in Workforce Development

    SciTech Connect (OSTI)

    2008-03-31

    This report documents the identification of key barriers in the development of an adequate national security workforce as part of the National Security Preparedness Project, being performed under a Department of Energy/National Nuclear Security Administration grant. Many barriers exist that prevent the development of an adequate number of propertly trained national security personnel. Some barriers can be eliminated in a short-term manner, whereas others will involve a long-term strategy that takes into account public policy.

  19. Key Physical Mechanisms in Nanostructured Solar Cells

    SciTech Connect (OSTI)

    Dr Stephan Bremner

    2010-07-21

    The objective of the project was to study both theoretically and experimentally the excitation, recombination and transport properties required for nanostructured solar cells to deliver energy conversion efficiencies well in excess of conventional limits. These objectives were met by concentrating on three key areas, namely, investigation of physical mechanisms present in nanostructured solar cells, characterization of loss mechanisms in nanostructured solar cells and determining the properties required of nanostructured solar cells in order to achieve high efficiency and the design implications.

  20. Realizing Technologies for Magnetized Target Fusion

    SciTech Connect (OSTI)

    Wurden, Glen A.

    2012-08-24

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  1. Rapid Compression Machine ? A Key Experimental Device to Effectively...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Compression Machine A Key Experimental Device to Effectively Collaborate with Basic Energy Sciences Rapid Compression Machine A Key Experimental Device to Effectively...

  2. Cooling Towers: Understanding Key Components of Cooling Towers...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve Water Efficiency Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve...

  3. Single, Key Gene Discovery Could Streamline Production of Biofuels...

    Energy Savers [EERE]

    Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels August 11, 2011 - 3:51pm Addthis WASHINGTON,...

  4. Building America Expert Meeting: Key Innovations for Adding Energy...

    Energy Savers [EERE]

    Expert Meeting: Key Innovations for Adding Energy Efficiency to Maintenance Projects Building America Expert Meeting: Key Innovations for Adding Energy Efficiency to Maintenance...

  5. Thailand-Key Results and Policy Recommendations for Future Bioenergy...

    Open Energy Info (EERE)

    Thailand-Key Results and Policy Recommendations for Future Bioenergy Development Jump to: navigation, search Name Thailand-Key Results and Policy Recommendations for Future...

  6. Technology Key to Harnessing Natural Gas Potential | Department...

    Office of Environmental Management (EM)

    Technology Key to Harnessing Natural Gas Potential Technology Key to Harnessing Natural Gas Potential July 18, 2012 - 3:52pm Addthis Deputy Secretary Daniel Poneman tours Proinlosa...

  7. Key Energy-Saving Projects for Smaller Facilities | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Energy-Saving Projects for Smaller Facilities Key Energy-Saving Projects for Smaller Facilities This presentation discusses how smaller industrial facilities can save energy...

  8. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    pdf. Accessed February 2011. Medco. 2010 Drug Trend Report.www.drugtrend.com/art/drug_trend/pdf/DT_Report_2010.pdf.chronic myeloid leukaemia. Drugs. 2007;67(2): p. 299- April

  9. Prescription Drug List effective January 1, 2015

    E-Print Network [OSTI]

    Arnold, Jonathan

    1 Your 2015 Prescription Drug List effective January 1, 2015 Student Resources Traditional ThreeZIPcode. ·Lookuppossiblelower-costmedicationalternatives. ·Comparemedicationpricingandoptions. #12;2 Your Prescription Drug List This Prescription Drug List (PDL) outlines the most commonly prescribed medications for certain

  10. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release is controlled by polymer degradation

  11. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    1 Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable The biodegradable polymer such as poly(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release

  12. Drug-Drug Interaction Detection: A New Approach Based on Maximal Frequent Sequences

    E-Print Network [OSTI]

    Rosso, Paolo

    Drug-Drug Interaction Detection: A New Approach Based on Maximal Frequent Sequences Detecci´on de´armacos, extracci´on de relaciones, secuencias frecuentes maximales Abstract: In this paper, a new approach for Drug-Drug that contain Drug-Drug Interactions. Maximal Frequent Sequences define word sequences that are frequent

  13. Magnetized Target Fusion Collaboration. Final report

    SciTech Connect (OSTI)

    John Slough

    2012-04-18

    Nuclear fusion has the potential to satisfy the prodigious power that the world will demand in the future, but it has yet to be harnessed as a practical energy source. The entry of fusion as a viable, competitive source of power has been stymied by the challenge of finding an economical way to provide for the confinement and heating of the plasma fuel. It is the contention here that a simpler path to fusion can be achieved by creating fusion conditions in a different regime at small scale (~ a few cm). One such program now under study, referred to as Magnetized Target Fusion (MTF), is directed at obtaining fusion in this high energy density regime by rapidly compressing a compact toroidal plasmoid commonly referred to as a Field Reversed Configuration (FRC). To make fusion practical at this smaller scale, an efficient method for compressing the FRC to fusion gain conditions is required. In one variant of MTF a conducting metal shell is imploded electrically. This radially compresses and heats the FRC plasmoid to fusion conditions. The closed magnetic field in the target plasmoid suppresses the thermal transport to the confining shell, thus lowering the imploding power needed to compress the target. The undertaking described in this report was to provide a suitable target FRC, as well as a simple and robust method for inserting and stopping the FRC within the imploding liner. The FRC must also survive during the time it takes for the metal liner to compress the FRC target. The initial work at the UW was focused on developing adequate preionization and flux trapping that were found to be essential in past experiments for obtaining the density, flux and most critically, FRC lifetime required for MTF. The timescale for testing and development of such a source can be rapidly accelerated by taking advantage of a new facility funded by the Department of Energy. At this facility, two inductive plasma accelerators (IPA) were constructed and tested. Recent experiments with these IPAs have demonstrated the ability to rapidly form, accelerate and merge two hypervelocity FRCs into a compression chamber. The resultant FRC that was formed was hot (T{sub ion} ~ 400 eV), stationary, and stable with a configuration lifetime several times that necessary for the MTF liner experiments. The accelerator length was less than 1 meter, and the time from the initiation of formation to the establishment of the final equilibrium was less than 10 microseconds. With some modification, each accelerator can be made capable of producing FRCs suitable for the production of the target plasma for the MTF liner experiment. Based on the initial FRC merging/compression results, the design and methodology for an experimental realization of the target plasma for the MTF liner experiment can now be defined. The construction and testing of the key components for the formation of the target plasma at the Air Force Research Laboratory (AFRL) will be performed on the IPA experiment, now at MSNW. A high density FRC plasmoid will be formed and accelerated out of each IPA into a merging/compression chamber similar to the imploding liner at AFRL. The properties of the resultant FRC plasma (size, temperature, density, flux, lifetime) will be obtained. The process will be optimized, and a final design for implementation at AFRL will be carried out. When implemented at AFRL it is anticipated that the colliding/merging FRCs will then be compressed by the liner. In this manner it is hoped that ultimately a plasma with ion temperatures reaching the 10 keV range and fusion gain near unity can be obtained.

  14. Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytoma

    E-Print Network [OSTI]

    Mercurio, Sandy; Padovani, Laetitia; Colin, Carole; Carré, Manon; Tchoghandjian, Aurélie; Scavarda, Didier; Lambert, Sally; Baeza-Kallee, Nathalie; Fernandez, Carla; Chappé, Céline; André, Nicolas; Figarella-Branger, Dominique

    2013-05-20

    , and IQGAP1) are targets for available drugs: fluvastatin and/or celecoxib. Results Quantification by RT-Q-PCR of the expression of these genes was performed in a series of 51 pilocytic astrocytomas and 10 glioblastomas: they were all significantly...

  15. Analysing ZigBee Key Establishment Protocols

    E-Print Network [OSTI]

    Yüksel, Ender

    2012-01-01

    In this report, we present our approach for protocol analysis together with a real example where we find an important flow in a contemporary wireless sensor network security protocol. We start by modelling protocols using a specific process algebraic formalism called LySa process calculus. We then apply an analysis based on a special program analysis technique called control flow analysis. We apply this technique to the ZigBee-2007 End-to-End Application Key Establishment Protocol and with the help of the analysis discover an unknown flaw. Finally we suggest a fix for the protocol, and verify that the fix works by using the same technique.

  16. Another key Y-12 General Foreman remembered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O O D S TAPropaneandAn319Another key Y-12 General Foreman

  17. Keyes, California: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View NewTexas: Energy ResourcesOrder atHills,NewKeithDelaware:DLRKettering,KeyTex Energy LLCKeyes,

  18. NERSC.COE.key.actions-4.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines light on77 PAGEMissionStressMoveMuncriefB ONERSCNERSC8 CoE Key Actions

  19. Composite keys? | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTIONRobertsdale, Alabama (Utility Company)| Open EnergyColoradoBiomassPlusComposite keys? Home >

  20. Fermilab | Science | Particle Physics | Key Discoveries

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you not find whatGasEnergyfeature photo featureParticleDark matterKey

  1. Key Actions for Optimizing for KNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse Bergkamp Graduate student Subtask 4Photo4> TheKevin Morris Title:AnaKey

  2. Bioenergy Key Publications | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsofProgram:Y-12Power, IncBio Centers Announcement at theproduceƈ GOAL:Key

  3. Fair Encryption of RSA Keys Guillaume Poupard and Jacques Stern

    E-Print Network [OSTI]

    Stern, Jacques

    based on verifiable encryption of secret keys using double decker exponentiation which makes the proofs

  4. Session-Key Generation using Human Passwords Only Oded Goldreich

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    Session-Key Generation using Human Passwords Only Oded Goldreich Department of Computer Science present session-key generation protocols in a model where the legitimate parties share only a human assumptions. Keywords: Session-key generation (authenticated key-exchange), mutual authentication proto- cols

  5. SessionKey Generation using Human Passwords Only # Oded Goldreich +

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    Session­Key Generation using Human Passwords Only # Oded Goldreich + Department of Computer Science present session­key generation protocols in a model where the legitimate parties share only a human setup assumptions. Keywords: Session­key generation (authenticated key­exchange), mutual authentication

  6. The impacts of urbanization on endangered florida key deer 

    E-Print Network [OSTI]

    Harveson, Patricia Moody

    2006-04-12

    of peninsular Florida. Key deer range is restricted to the Lower Florida Keys with approximately 60% residing on Big Pine Key and 15% residing on No Name Key which have undergone rapid human population growth and development over the past 30 years. Urban...

  7. Targets for Multimegawatt Proton Beams %%%%%%%%%%%%%%%&'())0

    E-Print Network [OSTI]

    McDonald, Kirk

    , 2003 http://puhep1.princeton.edu/mumu/target/ Sketches of a 4-MW Target Station Kirk T. Mc and granular targets. · Liquid target studies. · Continuing R&D (including targets for linear colliders). Kirk accelerator neutrino beams, where targetry is a major challenge. Kirk T. McDonald Fermilab Long Range Planning

  8. Targets and methods for target preparation for radionuclide production

    DOE Patents [OSTI]

    Zhuikov, Boris L; Konyakhin, Nicolai A; Kokhanyuk, Vladimir M; Srivastava, Suresh C

    2012-10-16

    The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti--Sb, Al--Sb, Cu--Sb, or Ni--Sb in order to produce radionuclides (e.g., tin-117 m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.

  9. Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates to paclitaxel and the subsequent ring-opening polymerization of lactide. The drug-initiated, controlled(-caprolactone)) was also achieved through drug/(BDI-II)ZnN(TMS)2-mediated controlled polymerization. These drug

  10. Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug-

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug- Poly(Ocarboxyanhydride) Nanoconjugates Qian Yin, Rong Tong,, Yunxiang Xu, Kwanghyun Baek of polymer-drug conjugates for nanoparticulate drug delivery: hydroxyl-containing drug (e.g., camptothecin

  11. Alcohol and Other Drugs -1 -Approved: 05/09/2014 Alcohol and Other Drugs

    E-Print Network [OSTI]

    Hammack, Richard

    Alcohol and Other Drugs - 1 - Approved: 05/09/2014 Alcohol and Other Drugs Policy Type: Board with the federal Drug Free Workplace Act of 1988, the federal Drug Free Schools and Communities Act of 1989, and the Commonwealth of Virginia's Policy on Alcohol and Other Drugs (AOD), it is the policy of Virginia Commonwealth

  12. Monotonic Target Assignment for Robotic Networks

    E-Print Network [OSTI]

    Smith, Stephen L; Bullo, Francesco

    2009-01-01

    Target assignment for robotic networks: Worst-case andTARGET ASSIGNMENT FOR ROBOTIC NETWORKS [6] H. W. Kuhn, “TheTarget Assignment for Robotic Networks Stephen L. Smith,

  13. Transmission Line MTF: Magnetized Target Fusion

    E-Print Network [OSTI]

    Transmission Line MTF: Magnetized Target Fusion Initial target: preheated & magnetized Subsequent for the FRC. Abstract Block Diagram theta coil transmission line Bias cap. bank maincapacitor inductor PI cap

  14. Enterprise Assessments Targeted Review, Argonne National Laboratory...

    Energy Savers [EERE]

    Targeted Review, Argonne National Laboratory - November 2014 Enterprise Assessments Targeted Review, Argonne National Laboratory - November 2014 November 2014 Review of the...

  15. A Prospective Target for Advanced Biofuel Production

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Prospective Target for Advanced Biofuel Production A Prospective Target for Advanced Biofuel Production Print Thursday, 02 February 2012 13:34 The sesquiterpene bisabolene was...

  16. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  17. Drug Trafficking Organizations and Counter-Drug Strategies in the U.S.-Mexican Context

    E-Print Network [OSTI]

    Astorga, Luis; Shirk, David A.

    2010-01-01

    Analytic Assessment of U.S. Drug Policy. Washington, D.C. ,K. (2008). Mexico Faces New Drug Challenge: Mini-Submarines.Mayors on Front Line of the Drug War. Los Angeles Times Los

  18. Electricity and Development: Global Trends and Key Challenges

    E-Print Network [OSTI]

    ;3. Prospects for Electricity Development Electricity Access Projected Electrification Rates by Region globalElectricity and Development: Global Trends and Key Challenges Romeo Pacudan, PhD Risoe National · Prospects for electricity development · Investment requirements · Key challenges · Final remarks #12

  19. Energy Storage: The Key to a Reliable, Clean Electricity Supply...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Storage: The Key to a Reliable, Clean Electricity Supply Energy Storage: The Key to a Reliable, Clean Electricity Supply February 22, 2012 - 4:52pm Addthis Improved energy...

  20. Exploring the context : a small hotel in Key West

    E-Print Network [OSTI]

    VanBeuzekom, Edrick

    1984-01-01

    This thesis develops a personal method and approach for designing in a delicate context such as the Key West Historic District. This thesis is composed of two parts. The first part presents observations of Key West, focusing ...

  1. SOW and Key Performance Parameters (KPP) Handbook Final Version...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    SOW and Key Performance Parameters (KPP) Handbook Final Version 9-30-2014 SOW and Key Performance Parameters (KPP) Handbook Final Version 9-30-2014 This handbook provides suggested...

  2. Could Solar Energy Storage be Key for Residential Solar? | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Could Solar Energy Storage be Key for Residential Solar? Could Solar Energy Storage be Key for Residential Solar? October 26, 2010 - 4:52pm Addthis This is the silent power storage...

  3. Target

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S. Coal StocksSuppliers Tag:TakeSeptember 13,Tara

  4. Relationship between key events in Earth history

    E-Print Network [OSTI]

    Gillman, Michael

    2015-01-01

    A model of cyclical (sinusoidal) motion of the solar system, intercepting event lines distributed at fixed intervals, explains the pattern of timings of mass extinctions, earlier glaciations, largest impact craters and the largest known extrusions of magma in the history of the Earth. The model reveals links between several sets of key events, including the end-Cretaceous and end-Ordovician extinctions with the Marinoan glaciation, and the end-Permian with the end-Serpukhovian extinctions. The model is supported by significant clusters of events and a significant reduction of impact crater size with position (sine value). The pattern of event lines is sustained to the earliest-dated impact craters (2023 and 1849 Ma) and to the origin of the solar system, close to 4567.4 Ma. The implication is that, for the entirety of its existence, the solar system has passed in a consistent manner through a predictably structured galaxy. Dark matter is a possible contender for the structure determining the event lines.

  5. Residential Energy Efficiency Financing: Key Elements of Program Design

    Broader source: Energy.gov [DOE]

    Presents key programmatic elements and context of financing initiatives, including contractor support, rebates, quality assurance, and more.

  6. APPENDIX E: ANSWER KEY TEMPLATES FOR TST2 SAMPLE TEXTS

    E-Print Network [OSTI]

    TRAFFICKERS" / "DRUG TRAFFICKERS " "PABLO ESCOBAR GAVIRIA" "TRUCK" / "TRUCK FULL OF POLICEMEN" "PUBLIC BUSES" "PABLO ESCOBAR GAVIRIA" "BERNARDO JARAMILLO OSSA " "LEFTIST PRESIDENTIAL CANDIDATE" : "BERNARDO "CHIEF

  7. Master Thesis Group Key Agreement for Ad Hoc Networks

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    Master Thesis Group Key Agreement for Ad Hoc Networks Lijun Liao Date: 06 July 2005 Supervisor: M their financial support. #12;Abstract Over the last 30 years the study of group key agreement has stimulated much present a Tree-based group key agreement Framework for Ad-hoc Networks (TFAN). TFAN is especially suitable

  8. Distributed Key Generation in the Wild Aniket Kate1

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    Distributed Key Generation in the Wild Aniket Kate1 Yizhou Huang2 Ian Goldberg2 1 Max Planck of Waterloo, Canada aniket@mpi-sws.org, {y226huan, iang}@uwaterloo.ca Abstract Distributed key generation (DKG communication model. computational setting. distributed key generation. uniform randomness. implementation 1

  9. A Linearization Attack on the Bluetooth Key Stream Generator

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    A Linearization Attack on the Bluetooth Key Stream Generator Frederik Armknecht ? University on the key stream generator underlying the E0 yet. 1 Introduction The encryption system E 0 , which key stream generator (KSG) is used. In this paper, we propose an attack on the underlying KSG. We

  10. Leakage-Resilient Cryptography with Key Derived from Sensitive Data

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    Leakage-Resilient Cryptography with Key Derived from Sensitive Data Konrad Durnoga , Tomasz Kazana subject to adversarial leakage. We propose a method to derive keys for such protocols on-the-fly from the actual keys are derived from. That is, an adversary can hardly gain any knowledge about the private data

  11. Mercury Intense Target (MERIT) Update

    E-Print Network [OSTI]

    McDonald, Kirk

    requirement for the system to deliver a 20 m/s jet - Two hydraulic cylinders drive a Hg cylinder - Stainless with Airline Hydraulics Co. today!) (2) Target Delivery System - Consists of primary and secondary containments, unconstrained jet of Hg in 1-atmosphere of air, into 15 Tesla field (Vacuum Is Under Review) #12;8 OAK RIDGE

  12. Complete Chaotic Mixing in an Electro-osmotic Flow by Destabilization of Key Periodic Pathlines

    E-Print Network [OSTI]

    R. Chabreyrie; C. Chandre; P. Singh; N. Aubry

    2011-02-07

    The ability to generate complete, or almost complete, chaotic mixing is of great interest in numerous applications, particularly for microfluidics. For this purpose, we propose a strategy that allows us to quickly target the parameter values at which complete mixing occurs. The technique is applied to a time periodic, two-dimensional electro-osmotic flow with spatially and temporally varying Helmoltz-Smoluchowski slip boundary conditions. The strategy consists of following the linear stability of some key periodic pathlines in parameter space (i.e., amplitude and frequency of the forcing), particularly through the bifurcation points at which such pathlines become unstable.

  13. A Novel Distributed Algorithm for Complete Targets Coverage in Energy Harvesting Wireless

    E-Print Network [OSTI]

    Chin, Kwan-Wu

    that utilizes energy efficiently. In particular, the key objective is to balance usage/demand and harvestedA Novel Distributed Algorithm for Complete Targets Coverage in Energy Harvesting Wireless Sensor Networks Changlin Yang School of Electrical, Computer and Telecommunications Engineering University

  14. POST-IRRADIATION PROPERTIES OF CANDIDATE MATERIALS FOR HIGH POWER TARGETS

    E-Print Network [OSTI]

    McDonald, Kirk

    POST-IRRADIATION PROPERTIES OF CANDIDATE MATERIALS FOR HIGH POWER TARGETS H. Kirk, N. Simos, P preliminary results of on-going experimental studies at BNL irradiation facilities. SEARCHING FOR SMART MATERIALS TO ACHIEVE >1 MW POWER Motivation Often dramatic change of key properties with irradiation (Figure

  15. Mass-limited Sn target irradiated by dual laser pulses for an extreme ultraviolet lithography source

    E-Print Network [OSTI]

    Najmabadi, Farrokh

    . However, at present, because of the high cost of the driving laser, the output power of the EUV light, and stable target supply is the key factor for lowering the critical requirements of the driving la- ser debris re- quires additional innovations for application to the practical EUV light source for HVM

  16. Enhanced Therapeutic Efficacy for Ovarian Cancer with a Serotype 3 Receptor-Targeted Oncolytic Adenovirus

    E-Print Network [OSTI]

    Hemminki, Akseli

    Enhanced Therapeutic Efficacy for Ovarian Cancer with a Serotype 3 Receptor-Targeted Oncolytic replicating adenovirus that does not bind CAR but facilitates entry into and killing of ovarian cancer cells interventions for ovarian cancer patients. Key Words: gene therapy, ovarian neoplasms, adenovirus, virus

  17. Packaging for a drug delivery microelectromechanical system

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2005-01-01

    Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

  18. Financing drug discovery for orphan diseases

    E-Print Network [OSTI]

    Fagnan, David Erik

    Recently proposed ‘megafund’ financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term ...

  19. Genome-Free Viral Capsids for Targeted Drug Delivery to Breast Cancer

    E-Print Network [OSTI]

    Wu, Wesley

    2012-01-01

    phage as determined by UV measurements at 260 nm (OD 260 /synthesizer. UV-Vis spectroscopic measurements were

  20. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis

    E-Print Network [OSTI]

    Farhat, Maha R.

    M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates, are incompletely ...

  1. A battle with superbugs : New compounds and targets against drug-resistant pathogens

    E-Print Network [OSTI]

    Haste, Nina M.

    2012-01-01

    of antimicrobial resistance in bacteria. Am J Med 119, S3-the intrinsic resistance properties of the bacteria andresistance seen to classical antibiotics. Many virulence factor inhibitors act to render the bacteria

  2. Applications and method development in the simulation of ligands binding to drug targets

    E-Print Network [OSTI]

    Sinko, William

    2012-01-01

    Chemical and Virtual Screening .23   Abstract: repeat Chemical and Protein Virtual Screening Abstract: PH

  3. Confidence from uncertainty - A multi-target drug screening method from robust control theory

    E-Print Network [OSTI]

    Luni, Camilla; Shoemaker, Jason E; Sanft, Kevin R; Petzold, Linda R; Doyle, Francis J

    2010-01-01

    method from robust control theory. BMC Systems Biology 2010method from robust control theory Camilla Luni 1 , Jason Eof a method from robust control theory, Structured Singular

  4. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles

    E-Print Network [OSTI]

    Simon, Scott I.

    is short (on the order of 10 min) [14,15]. Lipids grafted to polyethylene glycol (PEG) or other hydrophilic polymers have been shown to create so-called ``stealth'' particles that are shielded from the immune system

  5. Drug Target Optimization in Chronic Myeloid Leukemia Using Innovative Computational Platform

    E-Print Network [OSTI]

    Chuang, Ryan; Hall, Benjamin A.; Benque, David; Cook, Byron; Ishtiaq, Samin; Piterman, Nir; Taylor, Alex; Vardi, Moshe; Koschmieder, Steffen; Gottgens, Berthold; Fisher, Jasmin

    2015-02-03

    myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344, 1038-1042 (2001). 37. M. Eilers, R. N. Eisenman, Myc's broad reach. Genes Dev 22, 2755-2766 (2008). 38. B. P. Eliceiri, R. Paul, P. L. Schwartzberg, J... . Gewirtz, B. Perussia, B. Calabretta, Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome- positive cells. Blood 86, 726-736 (1995). 137. D. D. Spyropoulos, P. N. Pharr, K. R. Lavenburg...

  6. Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

    E-Print Network [OSTI]

    Tong, Liang

    is used as a building block to ex- tend the chain length of fatty acids in two carbon incre- ments). ACC is a CMLS, Cell. Mol. Life Sci. 62 (2005) 1784­1803 1420-682X/05/161784-20 DOI 10.1007/s00018-005-5121-4 © Birkhäuser Verlag, Basel, 2005 CMLS Cellular and Molecular Life Sciences multi-subunit enzyme in most

  7. The pipeline and future of drug development in schizophrenia

    E-Print Network [OSTI]

    Gray, J A; Roth, B L

    2007-01-01

    The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

  8. Drug transport in brain via the cerebrospinal fluid

    E-Print Network [OSTI]

    Pardridge, William M

    2011-01-01

    diffusion. Drug transport into cerebrospinal fluid vs. brainDrug transport from blood to interstitial fluid (ISF) isDrug transport in brain via the cerebrospinal fluid William

  9. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    of companies with the Danish Energy Agency, were made forMay 29, 2003. Danish Energy Agency, 2000. Green Taxes forDanish CO 2 -Tax Scheme,” in International Energy Agency,

  10. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    specified in the “Energy Technology List” on their income orappear on the 2004 Energy Technology List are: air-to-airEnergy, Industrial Technologies Program. http://www1.eere.energy.gov/industry/imf/pdfs/eeroci_dec03a.pdf SenterNovem presents lists

  11. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    Industrial Technologies Program provides many software tools, such as MotorMaster, for assessing energy efficiency of motors,

  12. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    tool called BEST: Benchmarking and Energy Saving Tool forinternational best practice energy use levels. Benchmarkingin Australian Wineries: Energy Efficiency Best Practice.

  13. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    See discussion of this report in ETSU, AEA Technology, 2001.environment/ccl/pdf/etsu- analysis.pdf Price, L. , Blok,a report prepared by ETSU (now AEA Energy & Environment) on

  14. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    www.unescap.org/esd/energy/publications/finance/index.htmlfor an energy efficiency project, limited finances, poorof Finance concluded that the business energy and CO 2 taxes

  15. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    Saving Opportunities for Breweries. Berkeley, CA: LawrenceLevel: Company Report Brewery. http://www.energyagency.at/attr=24 bakeries, breweries, fishing, meat, dairy, grain-

  16. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    manufacturing, and the pulp and paper industry were fullylime, pulp/paper, rubber, and solid wood industries. 51 The

  17. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    Global Reporting Initiative, Energy Consumption Protocol153 the Global Reporting Initiative’s Energy Consumption

  18. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    Berkeley National Laboratory’s Energy Analysis Program forare often national-level energy or GHG programs that combinea national-level energy or GHG emissions mitigation program

  19. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    d’Utilisation Rationnelle de l’Energie) Database. Availableen de la Maîtrise de l’Energie (ADEME) website: http://Investment Deduction (Energie Investeringsaftrek, EIA)

  20. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    Ireland, 2006. Energy Management Systems. I.S. 393:20052004. The Energy Management System Specification withA corporate energy management system can be expanded to

  1. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01

    BEST: Benchmarking and Energy Saving Tool for industry toregarding energy use and energy saving measures. Accordingand quantifies the energy savings and simple payback period

  2. CMVO Drug Testing Program Reasonable Suspicion Testing

    E-Print Network [OSTI]

    Sin, Peter

    CMVO Drug Testing Program Reasonable Suspicion Testing CMVO Revised Suspicion Form (Revised 6/08) Guidelines for Reasonable Suspicion Drug and Alcohol Testing: A supervisor, trained in accordance with 49 CFR involved in an incident that requires drug/alcohol testing as set forth in 382.307. Remember: Reasonable

  3. Drugs and Behavior (Psychology 320 Sec. 001)

    E-Print Network [OSTI]

    Hopfinger, Joseph B.

    1 Drugs and Behavior (Psychology 320 Sec. 001) Syllabus Example Text: Maisto, Galizio and Conners. Drug Use and Abuse. Harcourt Brace College Publishers. 2008, Fifth Edition. Prerequisites: This course of drugs of abuse. An overview of basic pharmacology and behavioral pharmacology will be provided followed

  4. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

    1984-01-01

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reaction accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  5. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

    1987-01-01

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reactions accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  6. Proctors' Memorandum on Drugs Misuse Guidelines from Proctors' Office on Dealing with Drugs Misuse

    E-Print Network [OSTI]

    Henderson, Gideon

    Proctors' Memorandum on Drugs Misuse Guidelines from Proctors' Office on Dealing with Drugs Misuse The use of specified drugs is illegal within the UK, and is inimical to the University's primary objectives of the pursuit of academic study and research. The presence of drugs within the University

  7. Experimenting with Drugs (and Topic Models): Multi-Dimensional Exploration of Recreational Drug Discussions

    E-Print Network [OSTI]

    Dredze, Mark

    Experimenting with Drugs (and Topic Models): Multi-Dimensional Exploration of Recreational Drug of new recreational drugs and trends re- quires mining current information from non-traditional text components. The resulting model learns factors that correspond to drug type, delivery method (smoking

  8. Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs

    E-Print Network [OSTI]

    Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs become empowered to share personal experiences regarding prescription drugs via Web page discussion from patient-provided drug reviews on health-related web sites. We focus on the statin class

  9. HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS

    E-Print Network [OSTI]

    Kim, Duck O.

    HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC AND OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS (5/3/2013) Introduction Drugs have a successful history of use in treating diseases and are responsible for many medical advances over the past century. However, virtually every drug has side effects

  10. Policy on Drug-Free Workplace Policy on Drug-Free Workplace

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Drug-Free Workplace 10/26/2014 Policy on Drug-Free Workplace I. Purpose and Scope responsible decision- making regarding the use of alcohol and other drugs. Northeastern strives to maintain drug use can create. Additionally, the University is committed to enforcing policies and laws relating

  11. Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrest

    SciTech Connect (OSTI)

    Kim, Ju-Hwa; Yoo, Hye-In; Kang, Han Sung; Ro, Jungsil [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)] [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of); Yoon, Sungpil, E-mail: yoons@ncc.re.kr [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)] [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)

    2012-02-03

    Highlights: Black-Right-Pointing-Pointer Sal sensitizes antimitotic drugs-treated cancer cells. Black-Right-Pointing-Pointer Sal sensitizes them by prevention of G2 arrest and reduced cyclin D1 levels. Black-Right-Pointing-Pointer Sal also sensitizes them by increasing DNA damage and reducing p21 level. Black-Right-Pointing-Pointer A low concentration of Sal effectively sensitized the cancer cells to antimitotic drugs. -- Abstract: Here, we investigated whether Sal could sensitize cancer cells to antimitotic drugs. We demonstrated that Sal sensitized paclitaxcel (PAC)-, docetaxcel (DOC)-, vinblastin (VIN)-, or colchicine (COL)-treated cancer cell lines, suggesting that Sal has the ability to sensitize the cells to any form of microtubule-targeting drugs. Sensitization to the antimitotic drugs could be achieved with very low concentrations of Sal, suggesting that there is a possibility to minimize Sal toxicity associated with human cancer patient treatments. Sensitization by Sal increased apoptosis, which was observed by C-PARP production. Sal sensitized the cancer cells to antimitotic drugs by preventing G2 arrest, suggesting that Sal contributes to the induction of mitotic catastrophe. Sal generally reduced cyclin D1 levels in PAC-, DOC-, and VIN-treated cells. In addition, Sal treatment increased pH2AX levels and reduced p21 levels in antimitotic drugs-treated cells. These observations suggest that the mechanisms underlying Sal sensitization to DNA-damaging compounds, radiation, and microtubule-targeting drugs are similar. Our data demonstrated that Sal sensitizes cancer cells to antimitotic drugs by increasing apoptosis through the prevention of G2 arrest via conserved Sal-sensitization mechanisms. These results may contribute to the development of Sal-based chemotherapy for cancer patients treated with antimitotic drugs.

  12. LIFE Target Fabrication Research Plan Sept 2008

    SciTech Connect (OSTI)

    Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

    2008-11-10

    The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

  13. Cyclin-dependent kinase inhibitor drugs drive neutrophil granulocyte apoptosis by transcriptional inhibition of the key survival protein MCL-1 

    E-Print Network [OSTI]

    Leitch, Andrew Edward

    2011-11-25

    The normal physiological response to bacterial infection or wounding with threat of infection, termed inflammation, has been shown to be dysregulated in certain human diseases including (but not limited to): idiopathic ...

  14. Drugs in Cinema: Separating the Myths from Reality

    E-Print Network [OSTI]

    Iannicelli, Paul

    2001-01-01

    Drugs in Cinema: Separating the Myths from Reality PaulSUMMARY 7 (2000). DRUGS IN CINEMA policy has a significantviolence in film. DRUGS IN CINEMA III. HISTORY OF DRUG USE

  15. Breast cancer drugs dampen vascular functions by interfering with nitric oxide signaling in endothelium

    SciTech Connect (OSTI)

    Gajalakshmi, Palanivel; Priya, Mani Krishna; Pradeep, Thangaraj; Behera, Jyotirmaya; Muthumani, Kandasamy; Madhuwanti, Srinivasan; Saran, Uttara; Chatterjee, Suvro

    2013-06-01

    Widely used chemotherapeutic breast cancer drugs such as Tamoxifen citrate (TC), Capecitabine (CP) and Epirubicin (EP) are known to cause various cardiovascular side-effects among long term cancer survivors. Vascular modulation warrants nitric oxide (NO) signal transduction, which targets the vascular endothelium. We hypothesize that TC, CP and EP interference with the nitric oxide downstream signaling specifically, could lead to cardiovascular dysfunctions. The results demonstrate that while all three drugs attenuate NO and cyclic guanosine mono-phosphate (cGMP) production in endothelial cells, they caused elevated levels of NO in the plasma and RBC. However, PBMC and platelets did not show any significant changes under treatment. This implies that the drug effects are specific to the endothelium. Altered eNOS and phosphorylated eNOS (Ser-1177) localization patterns in endothelial cells were observed following drug treatments. Similarly, the expression of phosphorylated eNOS (Ser-1177) protein was decreased under the treatment of drugs. Altered actin polymerization was also observed following drug treatment, while addition of SpNO and 8Br-cGMP reversed this effect. Incubation with the drugs decreased endothelial cell migration whereas addition of YC-1, SC and 8Br-cGMP recovered the effect. Additionally molecular docking studies showed that all three drugs exhibited a strong binding affinity with the catalytic domain of human sGC. In conclusion, results indicate that TC, CP and EP cause endothelial dysfunctions via the NO–sGC–cGMP pathway and these effects could be recovered using pharmaceutical agonists of NO signaling pathway. Further, the study proposes a combination therapy of chemotherapeutic drugs and cGMP analogs, which would confer protection against chemotherapy mediated vascular dysfunctions in cancer patients. - Highlights: • NO production is reduced in endothelial cells under breast cancer drug treatment. • Cellular cGMP level is decreased under the treatments of breast cancer drugs. • Breast cancer drugs induce vasoconstriction by interfering with NO pathway. • NO donors, cGMP analogs rescue breast cancer drug induced endothelial dysfunctions.

  16. Updated distribution and reintroduction of the Lower Keys marsh rabbit 

    E-Print Network [OSTI]

    Faulhaber, Craig Alan

    2005-02-17

    , for their advice and interest in the project. Kim Rohrs of the Monroe County Department of Planning and Environmental Resources provided valuable spatial and tabular data on land ownership and land-use planning in the Keys. My interns, Josh Harris, Kyle........................ 29 3.1 The number of individual Lower Keys marsh rabbits captured in 13 occupied populations on 4 keys from October 2001?August 2002. Data are arranged according to sex and age class...

  17. Vaginal mesh grafts and the Food and Drug Administration

    E-Print Network [OSTI]

    Ostergard, Donald R.

    2010-01-01

    and the Food and Drug Administration Donald R. Ostergardthe food and drug administration's (FDA) 510(k) process of

  18. Water dynamics clue to key residues in protein folding

    SciTech Connect (OSTI)

    Gao, Meng [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Zhu, Huaiqiu, E-mail: hqzhu@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Yao, Xin-Qiu [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China) [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Department of Biophysics, Kyoto University, Sakyo Kyoto 606-8502 (Japan); She, Zhen-Su, E-mail: she@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)

    2010-01-29

    A computational method independent of experimental protein structure information is proposed to recognize key residues in protein folding, from the study of hydration water dynamics. Based on all-atom molecular dynamics simulation, two key residues are recognized with distinct water dynamical behavior in a folding process of the Trp-cage protein. The identified key residues are shown to play an essential role in both 3D structure and hydrophobic-induced collapse. With observations on hydration water dynamics around key residues, a dynamical pathway of folding can be interpreted.

  19. Key Practical Issues in Strengthening Safety Culture, INSAG-15

    Broader source: Energy.gov [DOE]

    Key Pratical Issues in Strengthening Safety Culture, INSAG-15. A report by the International Nuclear Safety Advisory Gorup, International Atomic Energy Agency, Vienna, 2002.

  20. Deputy Secretary Sherwood-Randall Meets Key Government Officials...

    Broader source: Energy.gov (indexed) [DOE]

    Pritzker and Deputy Secretary Sherwood-Randall had the opportunity to engage with key Chinese government officials while in Beijing. Both met with Premier Li Keqiang and Vice...

  1. Climate Action Planning: A Review of Best Practices, Key Elements...

    Open Energy Info (EERE)

    Climate Action Planning: A Review of Best Practices, Key Elements, and Common Climate Strategies for Signatories to the American College & University Presidents' Climate Commitment...

  2. California Energy Incentive Programs An Annual Update on Key...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Issues and Financial Opportunities for Federal Sites in California California Energy Incentive Programs An Annual Update on Key Energy Issues and Financial Opportunities...

  3. Intercropped silviculture systems, a key to achieving soil fungal...

    Office of Scientific and Technical Information (OSTI)

    Intercropped silviculture systems, a key to achieving soil fungal community management in eucalyptus plantations Citation Details In-Document Search Title: Intercropped...

  4. Strategic Energy Management.  Keys to Behavioral and Operational Change.

    E-Print Network [OSTI]

    Kroll, Ryan M; Willems, Phil; Rubado, Dan; Belkhayat, Kathleen

    2015-01-01

    Strategic Energy Management Keys to Behavioral andof Oregon’s Strategic Energy Management (SEM) initiative.Introduction Strategic energy management (SEM) is defined

  5. MasterKey Cryptosystems AT&T Bell Labs

    E-Print Network [OSTI]

    Blaze, Matthew

    then be converted to a stream­ cipher via one of the usual block­chaining methods). We use the public­key encryption

  6. Pantex Plant Achieves Key Safety Milestone Ahead of Schedule...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Achieves Key Safety Milestone Ahead of Schedule | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing...

  7. Comparisons on thin and thick neutron target for low energy proton beam

    SciTech Connect (OSTI)

    Zhong, B.; Yu, G.; Wang, X.; Wang, K. [Dept. of Engineering Physics, Tsinghua Univ., Beijing 100084 (China)

    2012-07-01

    As the progress on accelerator physics and neutronics, the compact neutron sources driven by low energy and high intensity beam are becoming extensively developed and researched all around the world. The neutron target of an accelerator driven neutron source is one of the key components, and the stability of the neutron target affect the operation and performance of the neutron facility. When a low energy proton is projected to the beryllium target, the main reaction is the inelastic scattering between the proton and extra-nuclear electrons. As the decreasing of proton energy, the rate of elastic scattering between proton and target nucleus begins to increase. When the energy of proton is very low, the pickup charge reaction begins to appear. Focus on the problems brought by high intensity proton beam such as proton implantation, radiation damages, heat deposition and gas production, we performed sufficient numerical simulations for both thin and thick target determined by proton range. The results show that the critical problem for thick target is the proton implantation, causing the forming of bubbles and beryllium flaked in vacuum. The thin target sacrifices a little neutron yield, but avoid the proton stopped in target, and decrease the radiation damage and energy deposition. (authors)

  8. Testing Drugs Versus Testing For Drug Use: Private Risk Management in the Shadow of the Criminal Law

    E-Print Network [OSTI]

    MacCoun, Robert J.

    2007-01-01

    Preface: The Varieties of Drug Control at the Dawn of thetbl.1.1. Id. See Peter Reuter, Drug Use Measures: What AreBetween Student Illicit Drug Use and School Drug-Testing

  9. Cascaded target normal sheath acceleration

    SciTech Connect (OSTI)

    Wang, W. P.; Shen, B. F.; Zhang, X. M.; Wang, X. F.; Xu, J. C.; Zhao, X. Y.; Yu, Y. H.; Yi, L. Q.; Shi, Y.; Zhang, L. G.; Xu, T. J.; Xu, Z. Z.

    2013-11-15

    A cascaded target normal sheath acceleration (TNSA) scheme is proposed to simultaneously increase energy and improve energy spread of a laser-produced mono-energetic proton beam. An optimum condition that uses the maximum sheath field to accelerate the center of the proton beam is theoretically found and verified by two-dimensional particle-in-cell simulations. An initial 10 MeV proton beam is accelerated to 21 MeV with energy spread decreased from 5% to 2% under the optimum condition during the process of the cascaded TNSA. The scheme opens a way to scale proton energy lineally with laser energy.

  10. Radioactive targets for neutron-induced cross section measurements

    SciTech Connect (OSTI)

    Kronenberg, A. (Andreas); Bond, E. M. (Evelyn M.); Glover, S. E. (Samuel E.); Rundberg, R. S. (Robert S.); Vieira, D. J. (David J.); Esch, E. I. (Ernst-Ingo); Reifarth, R. (Rene); Ullmann, J. L. (John L.); Haight, Robert C.; Rochmann, D. (Dimitri)

    2004-01-01

    Measurements using radioactive targets are important for the determination of key reaction path ways associated with the synthesis of the elements in nuclear astrophysics (sprocess), advanced fuel cycle initiative (transmutation of radioactive waste), and stockpile stewardship. High precision capture cross-section measurements are needed to interpret observations, predict elemental or isotopical ratios, and unobserved abundances. There are two new detector systems that are presently being commissioned at Los Alamos National Laboratory for very precise measurements of (n,{gamma}) and (n,f) cross-sections using small quantities of radioactive samples. DANCE (Detector for Advanced Neutron-Capture Experiments), a 4 {pi} gamma array made up of 160 BaF{sub 2} detectors, is designed to measure neutron capture cross-sections of unstable nuclei in the low-energy range (thermal to {approx}500 keV). The high granularity and high detection efficiency of DANCE, combined with the high TOF-neutron flux available at the Lujan Center provides a versatile tool for measuring many important cross section data using radioactive and isotopically enriched targets of about 1 milligram. Another powerful instrument is the Lead-slowing down spectrometer (LSDS), which will enable the measurement of neutron-induced fission cross-section of U-235m and other short-lived actinides in a energy range from 1-200 keV with sample sizes down to 10 nanograms. Due to the short half-life of the U-235m isomer (T{sub 1/2} = 26 minutes), the samples must be rapidly and repeatedly extracted from its {sup 239}Pu parent. Since {sup 239}Pu is itself highly fissile, the separation must not only be rapid, but must also be of very high purity (the Pu must be removed from the U with a decontamination factor >10{sup 12}). Once extracted and purified, the {sup 235m}U isomer would be electrodeposited on solar cells as a fission detector and placed within the LSDS for direct (n,f) cross section measurements. The production of radioactive targets of a few milligrams will be described as well as the containment for safe handling of these targets at the Lujan Center at LANSCE. To avoid any contamination, the targets are electrochemically fixed onto thin Ti foils and two foils are placed back to back to contain the radioactive material within. This target sandwich is placed in a cylinder made of aluminum with thin translucent windows made of Kapton. Actinides targets, such as {sup 234,235,236,238}U, {sup 237}Np, and {sup 239}Pu are prepared by electrodeposition or molecular plating techniques. Target thicknesses of 1-2 mg/cm{sup 2} with sizes of 1 cm{sup 2} or more have been made. Other targets will be fabricated from separation of irradiated isotopically enriched targets, such as {sup 155}Eu from {sup 154}Sm,{sup 171}Tm from {sup 170}Er, and {sup 147}Pm from {sup 146}Nd, which has been irradiated in the high flux reactor at ILL, Grenoble. A radioactive sample isotope separator (RSIS) is in the process of being commissioned for the preparation of other radioactive targets. A brief summary of these experiments and the radioactive target preparation technique will be given.

  11. Review of the Renewable Energy Target

    E-Print Network [OSTI]

    Peters, Richard

    Review of the Renewable Energy Target Response to Expert Panel's Call for Submissions Paper #12;NSW Government Submission to the Review of the Renewable Energy Target, May 2014 2/20 Contents EXECUTIVE SUMMARY........................................................................................................................... 3 RENEWABLE ENERGY IN NSW

  12. Targets and processes for fabricating same

    SciTech Connect (OSTI)

    Cowna, Thomas; Malekos, Steven; Korgan, Grant; Adams, Jesse; Sentoku, Yasuhiko; LeGalloudec, Nathalie

    2014-06-10

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  13. Nanoparticles for targeting the infarcted heart

    E-Print Network [OSTI]

    Dvir, Tal

    We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in ...

  14. Solid Target Studies for NF Rob Edgecock

    E-Print Network [OSTI]

    McDonald, Kirk

    . Proposed lubricant (coating): WS2 Demonstrated to work to ~1300oC in vacuum. #12;Target Change #12;Target Calculations and Optimisation. John 4. Chain Design Optimisation ­ roller chain or alternative. David Consult

  15. Targets and processes for fabricating same

    DOE Patents [OSTI]

    Cowan, Thomas (Dresden, DE); Malekos, Steven (Reno, NV); Korgan, Grant (Reno, NV); Adams, Jesse (Reno, NV); Sentoku, Yasuhiko (Reno, NV); Le Galloudec, Nathalie (Reno, NV); Fuchs, Julien (Paris, FR)

    2012-07-24

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  16. Enterprise Assessments, Lessons Learned from Targeted Reviews...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    - November 2013 Enterprise Assessments Targeted Review, Argonne National Laboratory - November 2014 Enterprise Assessments Review, West Valley Demonstration Project - December...

  17. By Bruce Goldman The brain's key "breeder" cells, it turns

    E-Print Network [OSTI]

    Bogyo, Matthew

    including neurons. It's known that treating humans with radiation or drugs that prevent NPC rep- lication and graduate stu- dents were busy conducting experiments on proteins. A poster of the image of the "molecular

  18. Automatic Target Word Disambiguation Using Syntactic Relationships

    E-Print Network [OSTI]

    Automatic Target Word Disambiguation Using Syntactic Relationships Ebony Domingo1 and Rachel Edita. Multiple target translations are due to several meanings of source words, and various target word equivalents depending on the context of the source word. Thus, an automated approach is presented

  19. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a user of that drug (e.g. it produces a positive result with probability .98 in the case that the tested individual uses the drug) and 90% accurate in the case of a non

  20. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug .98 in the case that the tested individual uses the drug) and 90% accurate in the case of a non it is known that 10% of the entire population uses this drug. You test someone and the test is positive. What

  1. AES Flow Interception : Key Snooping Method on Virtual Machine.

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    AES Flow Interception : Key Snooping Method on Virtual Machine. - Exception Handling Attack for AES for snooping AES en- cryption key on Virtual Machine Monitor (VMM), and we present coun- termeasures against. In general, the virtualization technology composes two software parts: one is vir- tual machine (VM

  2. Entity Authentication and Authenticated Key Exchange with Tree Parity Machines

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    synchronization of two in­ teracting identically structured Tree Parity Machines (TPMs) has been proposed underEntity Authentication and Authenticated Key Exchange with Tree Parity Machines Markus Volkmer key exchange in the framework of Tree Parity Machines (TPMs). The interaction of TPMs has been

  3. Energy Security: A Key Requirement forSustainable Development

    E-Print Network [OSTI]

    1 Energy Security: A Key Requirement forSustainable Development Perspective and Action Plan Robert Card Under Secretary US Department of Energy August 30, 2002 Session One: Maintaining Energy Security WSSD Side Event Energy for Sustainable Development IEA/UNEP/Eskom #12;2 Energy Security is a Key

  4. A Distributed Public Key Caching Scheme in Large Wireless Networks

    E-Print Network [OSTI]

    Deng, Jing

    -constrained, in terms of computational power, battery energy, and on-board memory space. For example, the prototypeA Distributed Public Key Caching Scheme in Large Wireless Networks Yuan Kong Jing Deng Stephen R in wireless networks, the public keys of the nodes need to be widely available and signed by a Certificate

  5. Improved Key Generation For Gentry's Fully Homomorphic Encryption Scheme

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    Improved Key Generation For Gentry's Fully Homomorphic Encryption Scheme P. Scholl and N.P. Smart scheme was the slow key generation process. Gentry and Halevi provided a fast technique for 2-power cyclo. In particular they focused on the field generated by the polynomial F(X) = X2n + 1, but they noted

  6. Zero-one laws for connectivity in random key graphs

    E-Print Network [OSTI]

    Yagan, Osman

    with the random key predistribution scheme of Eschenauer and Gligor for wireless sensor networks. For this class which are more realistic for applications to wireless sensor networks. Keywords: Wireless sensor- dom key predistribution for wireless sensor networks (WSNs) [6], [7], [9]. For the sake

  7. Baton: Key Agility for Android without a Centralized Certificate Infrastructure

    E-Print Network [OSTI]

    Van Oorschot, Paul

    Baton: Key Agility for Android without a Centralized Certificate Infrastructure David Barrera,dmccarney}@ccsl.carleton.ca {clark,paulv}@scs.carleton.ca ABSTRACT Android's trust-on-first-use application signing model asso transfer signing au- thority to a new signing key. Our proposal, Baton, modifies Android's app installation

  8. Comparative Analysis of Software Libraries for Public Key Cryptography

    E-Print Network [OSTI]

    Gaj, Krzysztof

    Comparative Analysis of Software Libraries for Public Key Cryptography Ashraf Abusharekh1 and Kris libraries implementing such operations exist both commercially and in the public domain, in this paper, we, using performance and support of public key primitive operations. The performance of all libraries

  9. k-Connectivity in Random Key Graphs with Unreliable Links

    E-Print Network [OSTI]

    Yagan, Osman

    of Eschenauer and Gligor for securing wireless sensor network (WSN) communications. Random key graphs have real-world networks; e.g., with secure WSN application in mind, link unreliability can be attributed for securing WSN communications is the random predistribution of cryptographic keys to sensor nodes

  10. Wireless sensor networks under the random pairwise key predistribution scheme

    E-Print Network [OSTI]

    Yagan, Osman

    Wireless sensor networks under the random pairwise key predistribution scheme: Can resiliency, College Park, MD 20742. Email: armand@isr.umd.edu Abstract--We investigate the resiliency of wireless the classical key predistribution scheme of Eschenauer and Gligor. Keywords: Wireless sensor networks, Security

  11. Apparatus, system, and method for synchronizing a timer key

    DOE Patents [OSTI]

    Condit, Reston A; Daniels, Michael A; Clemens, Gregory P; Tomberlin, Eric S; Johnson, Joel A

    2014-04-22

    A timer key relating to monitoring a countdown time of a countdown routine of an electronic device is disclosed. The timer key comprises a processor configured to respond to a countdown time associated with operation of the electronic device, a display operably coupled with the processor, and a housing configured to house at least the processor. The housing has an associated structure configured to engage with the electronic device to share the countdown time between the electronic device and the timer key. The processor is configured to begin a countdown routine based at least in part on the countdown time, wherein the countdown routine is at least substantially synchronized with a countdown routine of the electronic device when the timer key is removed from the electronic device. A system and method for synchronizing countdown routines of a timer key and an electronic device are also disclosed.

  12. Practical issues in quantum-key-distribution postprocessing

    SciTech Connect (OSTI)

    Fung, C.-H. Fred; Chau, H. F. [Department of Physics and Center of Theoretical and Computational Physics, University of Hong Kong, Pokfulam Road (Hong Kong); Ma Xiongfeng [Institute for Quantum Computing and Department of Physics and Astronomy, University of Waterloo, 200 University Ave W., Waterloo, Ontario, Canada N2L 3G1 (Canada)

    2010-01-15

    Quantum key distribution (QKD) is a secure key generation method between two distant parties by wisely exploiting properties of quantum mechanics. In QKD, experimental measurement outcomes on quantum states are transformed by the two parties to a secret key. This transformation is composed of many logical steps (as guided by security proofs), which together will ultimately determine the length of the final secret key and its security. We detail the procedure for performing such classical postprocessing taking into account practical concerns (including the finite-size effect and authentication and encryption for classical communications). This procedure is directly applicable to realistic QKD experiments and thus serves as a recipe that specifies what postprocessing operations are needed and what the security level is for certain lengths of the keys. Our result is applicable to the BB84 protocol with a single or entangled photon source.

  13. PLUTONIUM-238 PRODUCTION TARGET DESIGN STUDIES

    SciTech Connect (OSTI)

    Hurt, Christopher J [ORNL; Wham, Robert M [ORNL; Hobbs, Randall W [ORNL; Owens, R Steven [ORNL; Chandler, David [ORNL; Freels, James D [ORNL; Maldonado, G Ivan [ORNL

    2014-01-01

    A new supply chain is planned for plutonium-238 using existing reactors at the Oak Ridge National Laboratory (ORNL) and Idaho National Laboratory (INL) and existing chemical recovery facilities at ORNL. Validation and testing activities for new irradiation target designs have been conducted in three phases over a 2 year period to provide data for scale-up to production. Target design, qualification, target fabrication, and irradiation of fully-loaded targets have been accomplished. Data from post-irradiation examination (PIE) supports safety analysis and irradiation of future target designs.

  14. Terahertz-based target typing.

    SciTech Connect (OSTI)

    Lyo, Sungkwun Kenneth; Wanke, Michael Clement; Reno, John Louis; Shaner, Eric Arthur; Grine, Albert D.; Barrick, Todd A.

    2008-09-01

    The purpose of this work was to create a THz component set and understanding to aid in the rapid analysis of transient events. This includes the development of fast, tunable, THz detectors, along with filter components for use with standard detectors and accompanying models to simulate detonation signatures. The signature effort was crucial in order to know the spectral range to target for detection. Our approach for frequency agile detection was to utilize plasmons in the channel of a specially designed field-effect transistor called the grating-gate detector. Grating-gate detectors exhibit narrow-linewidth, broad spectral tunability through application of a gate bias, and no angular dependence in their photoresponse. As such, if suitable sensitivity can be attained, they are viable candidates for Terahertz multi-spectral focal plane arrays.

  15. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  16. Fabrication of boron sputter targets

    DOE Patents [OSTI]

    Makowiecki, Daniel M. (Livermore, CA); McKernan, Mark A. (Livermore, CA)

    1995-01-01

    A process for fabricating high density boron sputtering targets with sufficient mechanical strength to function reliably at typical magnetron sputtering power densities and at normal process parameters. The process involves the fabrication of a high density boron monolithe by hot isostatically compacting high purity (99.9%) boron powder, machining the boron monolithe into the final dimensions, and brazing the finished boron piece to a matching boron carbide (B.sub.4 C) piece, by placing aluminum foil there between and applying pressure and heat in a vacuum. An alternative is the application of aluminum metallization to the back of the boron monolithe by vacuum deposition. Also, a titanium based vacuum braze alloy can be used in place of the aluminum foil.

  17. Target Fabrication: A View from the Users

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Barnes, Cris W.; Batha, Steven H.; Christensen, Cindy R.; Cobble, James A.; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael; Swift, Damian; Workman, Jonathan

    2004-03-15

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  18. TARGET FABRICATION: A VIEW FROM THE USERS.

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Batha, Steven H.; Barnes, Cris W.; Christensen, Cindy; Cobble, James; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael S.; Swift, Damian; Workman, Jonathan

    2003-07-18

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in time to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  19. Ignition of deuterium-tritium fuel targets

    DOE Patents [OSTI]

    Musinski, D.L.; Mruzek, M.T.

    1991-08-27

    Disclosed is a method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom. 5 figures.

  20. Emerging pathogens: Dynamics, mutation and drug resistance

    SciTech Connect (OSTI)

    Perelson, A.S.; Goldstein, B.; Korber, B.T. [and others

    1997-10-01

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objectives of this project were to develop models of the spread of pathogens, such as HIV-1 and influenza, in humans, and then to use the models to address the possibility of designing appropriate drug therapies that may limit the ability of the pathogen to escape treatment by mutating into a drug resistant form. We have developed a model of drug-resistance to amantidine and rimantadine, the two major antiviral drugs used to treat influenza, and have used the model to suggest treatment strategies during an epidemic.

  1. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    drugs related to infertility treatment (for those plans thatloss treatments; infertility treatments; smoking cessationfor the treatment of sexual dysfunction and infertility). In

  2. Thin-thick hydrogen target for nuclear physics

    SciTech Connect (OSTI)

    Gheller, J.-M.; Juster, F.-P.; Authelet, G. [CEA Saclay, Irfu/SACM, F-91191 Gif-Sur-Yvette cedex (France); Vinyar, I. [PELIN Limited Liability Company 27 A, Gzhatskaya Str, office 103 St. Petersbourg 195220 (Russian Federation); Relland, J. [CEA Saclay, Irfu/SIS, F-91191 Gif-Sur-Yvette cedex (France); Commeaux, C. [Institut de Physique Nucléaire, campus Universitaire-Bat 103, 91406 Orsay cedex (France)

    2014-01-29

    In spectroscopic studies of unstable nuclei, hydrogen targets are of key importance. The CHyMENE Project aims to provide to the nuclear physics community a thin and pure solid windowless hydrogen or deuterium target. CHyMENE project must respond to this request for the production of solid Hydrogen. The solid hydrogen target is produced in a continuous flow (1 cm/s) by an extrusion technique (developed with the PELIN laboratory) in a vacuum chamber. The shape of the target is determined by the design of the nozzle at the extrusion process. For the purpose, the choice is a rectangular shape with a width of 10 mm and a thickness in the range of 30-50 microns necessary for the physics objectives. The cryostat is equipped with a GM Cryocooler with sufficient power for the solidification of the hydrogen in the lower portion of the extruder. In the higher part of the cryostat, the hydrogen gas is first liquefied and partially solidified. It is then compressed at 100 bars in the cooled extruder before expulsion of the film through the nozzle at the center of the reaction vacuum chamber. After the previous step, the solid hydrogen ribbon falls by gravity into a dedicated chamber where it sublimes and the gas is pumped and evacuated in a exhaust line. This paper deals with the design of the cryostat with its equipment, with the sizing of the thermal bridge (Aluminum and copper), with the results regarding the contact resistance as well as with the vacuum computations of the reaction and recovery hydrogen gas chambers.

  3. Key Facts about Argonne National Laboratory | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousand Cubic Feet) SoldDepartment ofKenThousandtheKevlarKeyKeyKey

  4. Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs

    E-Print Network [OSTI]

    Liu, Mei; Wu, Yonghui; Chen, Yukun; Sun, Jingchun; Zhao, Zhongming; Chen, Xue-wen; Matheny, Michael Edwin; Xu, Hua

    2012-06-19

    Abstract Objective Adverse drug reaction (ADR) is one of the major causes of failure in drug development. Severe ADRs that go undetected until the post-marketing phase of a drug often lead to patient morbidity. Accurate prediction of potential ADRs...

  5. Drug Testing Notification Form RV 2 May 22, 2013 DRUG TESTING NOTIFICATION FORM

    E-Print Network [OSTI]

    Drug Testing Notification Form RV 2 May 22, 2013 DRUG TESTING NOTIFICATION FORM Section 1: Employer testing collector. You are required to undergo urine drug testing as a condition of hiring. You must have of Collection: ___________________________ Date and time of Test* * For testing out side of Louisiana testing

  6. Table I: Technical Targets for Catalyst Coated Membranes (CCMs...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    I: Technical Targets for Catalyst Coated Membranes (CCMs): Automotive Table I: Technical Targets for Catalyst Coated Membranes (CCMs): Automotive Technical targets for fuel cell...

  7. Security bounds for efficient decoy-state quantum key distribution

    E-Print Network [OSTI]

    Marco Lucamarini; James F. Dynes; Bernd Fröhlich; Zhiliang Yuan; Andrew J. Shields

    2015-03-25

    Information-theoretical security of quantum key distribution (QKD) has been convincingly proven in recent years and remarkable experiments have shown the potential of QKD for real world applications. Due to its unique capability of combining high key rate and security in a realistic finite-size scenario, the efficient version of the BB84 QKD protocol endowed with decoy states has been subject of intensive research. Its recent experimental implementation finally demonstrated a secure key rate beyond 1 Mbps over a 50 km optical fiber. However the achieved rate holds under the restrictive assumption that the eavesdropper performs collective attacks. Here, we review the protocol and generalize its security. We exploit a map by Ahrens to rigorously upper bound the Hypergeometric distribution resulting from a general eavesdropping. Despite the extended applicability of the new protocol, its key rate is only marginally smaller than its predecessor in all cases of practical interest.

  8. OIMB GK12 CURRICULUM Name: _____KEY__________ Fun Crab Facts!

    E-Print Network [OSTI]

    OIMB GK12 CURRICULUM Name: _____KEY__________ Fun Crab Facts! Eyestalk mouth antenna cheliped CURRICULUM Name: _____________________ Fun Crab Facts! Eyestalk Mouth Antenna Cheliped Carapace Walking metamorphosis motorcycle exoskeleton omnivores butterfly pea #12;OIMB GK12 CURRICULUM Masked crab Fiddler crab

  9. EnergySmart Schools National Financing Roundtable - Key Outcomes

    SciTech Connect (OSTI)

    2009-04-01

    This document presents key outcomes from the EnergySmart Schools National Financing Roundtable as a follow-up to the release of its Guide to FInancing EnergySmart Schools

  10. LANL breaks ground on key sediment control project

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately 2 million features are up to eight feet high and made of rocks...

  11. Turbulence may be key to "fast magnetic reconnection" mystery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A paper published in the journal Nature asserts to have found the key to a long-standing mystery in plasma physics and astrophysics, and it's all about turbulence....

  12. Refine the Concept of Public Key Encryption with Delegated Search

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    with the public key of Bob, but unfortunately, her computer is infected by some virus which embeds a malware contents. However, in this way, Bob's computer will be under the risk of infection by the malware

  13. Worldwide Trends in Energy Use and Efficiency: Key Insights from...

    Open Energy Info (EERE)

    Trends in Energy Use and Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Jump to:...

  14. A Key Review On Exergetic Analysis And Assessment Of Renewable...

    Open Energy Info (EERE)

    A Key Review On Exergetic Analysis And Assessment Of Renewable Energy Resources For A Sustainable Future Jump to: navigation, search OpenEI Reference LibraryAdd to library Journal...

  15. Mind Your Manners: Socially Appropriate Wireless Key Establishment for Groups

    E-Print Network [OSTI]

    Xu, Wenyuan

    Mind Your Manners: Socially Appropriate Wireless Key Establishment for Groups Cynthia Kuo Ahren students may want to (quietly) opt out of their friends' illicit file trading activities, but academics

  16. Practical Non-Interactive Key Distribution Based on Pairings

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    , the Private Key Generator (PKG), who possesses additional privileged information in the form of a master in a non- interactive system is that the synchronous communication between Alice and Bob is replaced

  17. Efficiency in Quantum Key Distribution Protocols using entangled Gaussian states

    E-Print Network [OSTI]

    Carles Rodó

    2010-05-14

    Efficiency is a key issue in any real implementation of a cryptographic protocol since the physical resources are not unlimited. We will first show that Quantum Key Distribution is possible with an "Entanglement based" scheme with NPPT symmetric Gaussian states in spite of the fact that these systems cannot be distilled with Gaussian operations (they are all bound entangled). In this work we analyze the secrecy properties of Gaussian states under Gaussian operations. Although such operations are useless for quantum distillation, we prove that it is possible to distill efficiently a secret key secure against finite coherent attacks from sufficiently entangled Gaussian states with non-positive partial transposition. Moreover, all such states allow for efficient key distillation, when the eavesdropper is assumed to perform individual attacks before in an efficient way.

  18. Reflective cracking of shear keys in multi-beam bridges 

    E-Print Network [OSTI]

    Sharpe, Graeme Peter

    2009-06-02

    strength to resist cracking from vehicular loads, but uneven temperature changes and shrinkage strains cause high tensile stresses in the shear key regions and lead to reflective cracking. The analyses showed the highest stresses were often times near...

  19. Key Factors in Displacement Ventilation Systems for Better IAQ 

    E-Print Network [OSTI]

    Wang, X.; Chen, J.; Li, Y.; Wang, Z.

    2006-01-01

    This paper sets up a mathematical model of three-dimensional steady turbulence heat transfer in an air-conditioned room of multi-polluting heat sources. Numerical simulation helps identify key factors in displacement ventilation systems that affect...

  20. Darcy Q. Hou State Key Laboratory of Hydraulic

    E-Print Network [OSTI]

    Tijsseling, A.S.

    Darcy Q. Hou State Key Laboratory of Hydraulic Engineering Simulation and Safety, and School to severe dam- ages. Over 50 incidents have been attributed to this mechanism and an accident was reported

  1. Cold Boot Key Recovery by Solving Polynomial Systems with Noise

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    the observed set of round subkeys in memory (computed via the cipher's key schedule operation), which were, for transparent en- cryption and decryption of data. One could apply the method from [9] to obtain the computer

  2. POLICY STATEMENT ON DRUG-FREE CAMPUS*

    E-Print Network [OSTI]

    Karsai, Istvan

    11 POLICY STATEMENT ON DRUG-FREE CAMPUS* It is the policy of ETSU that the unlawful manufacture, distribution, possession, use of alcohol and illicit drugs on the ETSU campus, in the workplace (on or off campus), on property owned or controlled by ETSU, or as part of any activity of ETSU is strictly

  3. Antiplatelet and Anticoagulant Drugs in Interventional Radiology

    SciTech Connect (OSTI)

    Altenburg, Alexander; Haage, Patrick, E-mail: patrick.haage@helios-kliniken.de [University Hospital Witten/Herdecke, Department of Diagnostic and Interventional Radiology, HELIOS Klinikum Wuppertal (Germany)

    2012-02-15

    In treating peripheral arterial disease, a profound knowledge of antiplatelet and anticoagulative drug therapy is helpful to assure a positive clinical outcome and to anticipate and avoid complications. Side effects and drug interactions may have fatal consequences for the patient, so interventionalists should be aware of these risks and able to control them. Aspirin remains the first-line agent for antiplatelet monotherapy, with clopidogrel added where dual antiplatelet therapy is required. In case of suspected antiplatelet drug resistance, the dose of clopidogrel may be doubled; prasugrel or ticagrelor may be used alternatively. Glycoprotein IIb/IIIa inhibitors (abciximab or eptifibatide) may help in cases of hypercoagulability or acute embolic complications. Desmopressin, tranexamic acid, or platelet infusions may be used to decrease antiplatelet drug effects in case of bleeding. Intraprocedurally, anticoagulant therapy treatment with unfractionated heparin (UFH) still is the means of choice, although low molecular-weight heparins (LMWH) are suitable, particularly for postinterventional treatment. Adaption of LMWH dose is often required in renal insufficiency, which is frequently found in elderly patients. Protamine sulphate is an effective antagonist for UFH; however, this effect is less for LMWH. Newer antithrombotic drugs, such as direct thrombin inhibitors or factor X inhibitors, have limited importance in periprocedural treatment, with the exception of treating patients with heparin-induced thrombocytopenia (HIT). Nevertheless, knowing pharmacologic properties of the newer drugs facilitate correct bridging of patients treated with such drugs. This article provides a comprehensive overview of antiplatelet and anticoagulant drugs for use before, during, and after interventional radiological procedures.

  4. Pricing in the Market for Anticancer Drugs

    E-Print Network [OSTI]

    Howard, David H.

    In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab— brand name Yervoy—at $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

  5. Liquid Hydrogen Target for the COMPASS experiment

    E-Print Network [OSTI]

    Bremer, J; Duday-Chanat, L; Geyer, R; Mallot, G K; Pirotte, O; Vullierme, B

    2014-01-01

    A liquid hydrogen target has been developed for the COMPASS experiment at CERN. The target has a diameter of 40 mm and a length of 2.5 meter, creating an active volume of about 3 liter of liquid hydrogen. The cylindrical part of the target wall is formed by a Kapton® foil strip, wound and glued to a thickness of 0.125 mm. The Kapton® foil is used to minimize the energy loss of the particles, scattered or created within the target volume, crossing the target boundary. The two end-caps enclosing the target volume have been fabricated from Mylar®. The system is cooled with a 30 W at 20 K cryocooler, delivering the cooling capacity for the cool-down as well as for the continuous operation of the system.

  6. THERMAL OSCILLATIONS IN LIQUID HELIUM TARGETS.

    SciTech Connect (OSTI)

    WANG,L.; JIA,L.X.

    2001-07-16

    A liquid helium target for the high-energy physics was built and installed in the proton beam line at the Alternate Gradient Synchrotron of Brookhaven National Laboratory in 2001. The target flask has a liquid volume of 8.25 liters and is made of thin Mylar film. A G-M/J-T cryocooler of five-watts at 4.2K was used to produce liquid helium and refrigerate the target. A thermosyphon circuit for the target was connected to the J-T circuit by a liquid/gas separator. Because of the large heat load to the target and its long transfer lines, thermal oscillations were observed during the system tests. To eliminate the oscillation, a series of tests and analyses were carried out. This paper describes the phenomena and provides the understanding of the thermal oscillations in the target system.

  7. Quantum Public-Key Encryption with Information Theoretic Security

    E-Print Network [OSTI]

    Jiangyou Pan; Li Yang

    2012-02-20

    We propose a definition for the information theoretic security of a quantum public-key encryption scheme, and present bit-oriented and two-bit-oriented encryption schemes satisfying our security definition via the introduction of a new public-key algorithm structure. We extend the scheme to a multi-bitoriented one, and conjecture that it is also information theoretically secure, depending directly on the structure of our new algorithm.

  8. Tensor Target Polarization at TRIUMF

    SciTech Connect (OSTI)

    Smith, G

    2014-10-27

    The first measurements of tensor observables in $\\pi \\vec{d}$ scattering experiments were performed in the mid-80's at TRIUMF, and later at SIN/PSI. The full suite of tensor observables accessible in $\\pi \\vec{d}$ elastic scattering were measured: $T_{20}$, $T_{21}$, and $T_{22}$. The vector analyzing power $iT_{11}$ was also measured. These results led to a better understanding of the three-body theory used to describe this reaction. %Some measurements were also made in the absorption and breakup channels. A direct measurement of the target tensor polarization was also made independent of the usual NMR techniques by exploiting the (nearly) model-independent result for the tensor analyzing power at 90$^\\circ _{cm}$ in the $\\pi \\vec{d} \\rightarrow 2p$ reaction. This method was also used to check efforts to enhance the tensor polarization by RF burning of the NMR spectrum. A brief description of the methods developed to measure and analyze these experiments is provided.

  9. Illegal Drugs Policy Swansea University and Students' Union

    E-Print Network [OSTI]

    Martin, Ralph R.

    Illegal Drugs Policy Swansea University and Students' Union #12;Illegal Drugs Policy for Swansea University and Students' Union Table of Contents Page Drugs Policy Statement 2 Drugs Policy 3 1. Introduction 2. Who is covered by the policy? 3. Aims of the policy 5. What do we mean by illegal drugs? 4

  10. Enterprise Assessments Targeted Review, Sandia National Laboratories...

    Energy Savers [EERE]

    Nuclear Security Administration sites that perform work at nuclear facilities and other high consequence hazards (e.g., chemical and biological). This targeted review area also...

  11. Enterprise Assessments Targeted Review, Lawrence Livermore National...

    Office of Environmental Management (EM)

    National Laboratory - February 2015 February 2015 Targeted Review of the Safety-Class Room Ventilation Systems and Associated Final Filtration Stages, and Review of Federal...

  12. Project Plan Remote Target Fabrication Refurbishment Project

    SciTech Connect (OSTI)

    Bell, Gary L; Taylor, Robin D

    2009-08-01

    In early FY2009, the DOE Office of Science - Nuclear Physics Program reinstated a program for continued production of {sup 252}Cf and other transcurium isotopes at the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). The FY2009 major elements of the workscope are as follows: (1) Recovery and processing of seven transuranium element targets undergoing irradiation at the High Flux Isotope Reactor (HFIR) at ORNL; (2) Development of a plan to manufacture new targets for irradiation beginning in early- to mid-FY10 to supply irradiated targets for processing Campaign 75 (TRU75); and (3) Refurbishment of the target manufacturing equipment to allow new target manufacture in early FY10 The {sup 252}Cf product from processing Campaign 74 (recently processed and currently shipping to customers) is expected to supply the domestic demands for a period of approximately two years. Therefore it is essential that new targets be introduced for irradiation by the second quarter of FY10 (HFIR cycle 427) to maintain supply of {sup 252}Cf; the average irradiation period is {approx}10 HFIR cycles, requiring about 1.5 calendar years. The strategy for continued production of {sup 252}Cf depends upon repairing and refurbishing the existing pellet and target fabrication equipment for one additional target production campaign. This equipment dates from the mid-1960s to the late 1980s, and during the last target fabrication campaign in 2005- 2006, a number of component failures and operations difficulties were encountered. It is expected that following the target fabrication and acceptance testing of the targets that will supply material for processing Campaign 75 a comprehensive upgrade and replacement of the remote hot-cell equipment will be required prior to subsequent campaigns. Such a major refit could start in early FY 2011 and would take about 2 years to complete. Scope and cost estimates for the repairs described herein were developed, and authorization for the work was received in July 2009 under the Remote Target Fabrication Refurbishment Task of the Enhanced Utilization of Isotope Facilities project (Project Identification Code 2005230) funded by the American Recovery and Reinvestment Act of 2009. The goal of this project is to recover the capability to produce 4-5 curium targets for the irradiation period starting with HFIR cycle 427, currently scheduled to begin 2/17/10. Assuming success, the equipment would then be used to fabricate 6-7 additional targets to hold for the next irradiation campaign specified by the program. Specific objectives are the return to functionality of the Cubicle 3 Pellet Fabrication Line; Cubicle 2 Target Assembly equipment; and Cubicle 1 Target Inspection and Final Assembly system.

  13. Implications of structural genomics target selection strategies...

    Office of Scientific and Technical Information (OSTI)

    Implications of structural genomics target selection strategies: Pfam5000, whole genome, and random approaches Citation Details In-Document Search Title: Implications of structural...

  14. Setting Energy Savings Targets for Utilities

    SciTech Connect (OSTI)

    none,

    2011-09-01

    Helps policymakers understand how electric and natural gas utilities can achieve greater efficiency by establishing numeric energy savings targets and goals for energy efficiency programs.

  15. Bacteria-targeting nanoparticles for managing infections

    E-Print Network [OSTI]

    Radovic-Moreno, Aleksandar Filip

    2013-01-01

    Bacterial infections continue to be a significant concern particularly in healthcare settings and in the developing world. Current challenges include the increasing spread of drug resistant (DR) organisms, the side effects ...

  16. Thermal-hydraulic analysis of the LANL/IPPE/EDO-GP 1-MW LBE target

    SciTech Connect (OSTI)

    He, X.; Ammerman, C.; Woloshun, K.; Li, N.

    2000-07-01

    The accelerator-driven transmutation of waste (ATW) concept has been proposed by the United States and other countries to transmute plutonium, higher actinides, and other environmentally hazardous fission products. One of the key components in the ATW concept is a target that, via spallation, produces neutrons to transmute nuclear waste. Since significant heat is generated during fissioning of the waste actinides, an efficient heat removal system is necessary. Liquid lead-bismuth eutectic (LBE) is an efficient coolant as well as a good spallation target for production of neutrons. The LBE coolant technology has been successfully used in Russian submarine nuclear reactors. The International Science and Technology Center (ISTC) has funded the Institute of Physics and Power Engineering (IPPE) and the Experiment and Design Organization-Gidropress (EDO-GP) of Russia to design and manufacture a pilot target (Target Circuit One-TC1) that incorporates Russian LBE technology into the ATW concept. The target will be tested in the 800-MeV, 1-mA proton beam at the Los Alamos National Laboratory (LANL) in 2 yr. These target experiments will provide valuable information on the performance of LBE as both spallation target and coolant. They will also help to design target/blanket systems for future ATW facilities. In summary, the authors have carried out thermal-hydraulic analyses for the LANL/IPPE/EDO-GP 1-MW LBE target. It is shown that the current design is suitable for the beam-on tests. The diffuser plate successfully enhances the coolant flow around the window center but still avoids generating recirculation zone downstream. The temperature range is within the proper operation range for both the LBE coolant and the structural materials.

  17. Modeling Multiple Drugs on Lung Cancer and Normal Cells using Regression

    E-Print Network [OSTI]

    Chen, Michelle

    2013-01-01

    Drug Combination . . . . . . . . . . . . . . . .n 27 vii List of Tables Drug Concentration . . . . . . .Factorial Designs in Antiviral Drug Stud- ies. ” Quality and

  18. Explanations of FreedomCAR/DOE Hydrogen Storage Technical Targets

    Broader source: Energy.gov [DOE]

    Summary of FreedomCAR Targets and Basis for Targets prepared for the Grand Challenge Hydrogen Storage Solicitation.

  19. An implantable device for localized drug delivery and sensing

    E-Print Network [OSTI]

    Daniel, Karen D

    2009-01-01

    There are many potential clinical applications for localized drug delivery and sensing systems, such as cancer, vaccinations, pain management, and hormone therapy. Localized drug delivery systems reduce the amount of drug ...

  20. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print Tuesday, 23 June 2015 13:00 The cancer drug...

  1. Prescription Drug Monitoring Programs: Examining Limitations and Future Approaches

    E-Print Network [OSTI]

    Griggs, Christopher A.; Weiner, Scott G.; Feldman, James A.

    2015-01-01

    Li G, Brady JE, Lang B, et al. Prescription drug monitoringand drug overdose mortality. Inj Epidemiol. 2014;1:1-9.EM, Desai HA. Prescription drug monitoring programs and

  2. Drugs in Cinema: Separating the Myths from Reality

    E-Print Network [OSTI]

    Iannicelli, Paul

    2001-01-01

    Introduction: The Evolution of Drug Abuse in Americain HAND- BOOK OF DRUG CONTROL IN THE UNITED STATES (James A.See JOSEPH SPILLANE, MODERN DRUG, MODERN MENANCE 214 (1994).

  3. Optimizing Combination Therapies with Existing and Future CML Drugs

    E-Print Network [OSTI]

    Katouli, Allen A.; Komarova, Natalia L.

    2010-01-01

    kinase inhibitors. Nat Rev Drug Discov 3: 1001–10. 12.screen: high efficacy of drug combinations. Blood 108: 2332–Abl kinase domain mutations, drug resistance, and the road

  4. The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

    E-Print Network [OSTI]

    Shugarts, Sarah; Benet, Leslie Z.

    2009-01-01

    A, Benet LZ. Effects of drug transporters on volume of4. Mizuno N, Sugiyama Y. Drug transporters: their role andand development of new drugs. Drug Metab. Pharmacokinet.

  5. A method for comparing impacts with real targets to impacts onto the IAEA unyielding target

    SciTech Connect (OSTI)

    Ammerman, D. J.

    1991-01-01

    The severity of the IAEA accident conditions test requirement (IAEA 1990) of an impact onto an essentially unyielding target from a drop height of 9 meters encompasses a large fraction of all real world impacts. This is true, in part, because of the unyielding nature of the impact target. Impacts onto the unyielding target have severities equivalent to higher velocity impacts onto real targets which are not unyielding. The severity of impacts with yielding targets is decreased by the amount of the impact energy absorbed in damaging the target. In demonstrating the severity of the regulatory impact event it is advantageous to be able to relate this impact onto an essentially unyielding target to impacts with yielding targets.

  6. Development of granular target for CADS

    E-Print Network [OSTI]

    McDonald, Kirk

    deposited by proton beam ~ X kW/cm^3 Industrial facility ~50MW=2.0GeV@25mA accelerator Spallation target, spheres, or plates to produce the neutrons, and coolant flowing between the elements for heat removal. · Liquid target options where a flowing liquid metal acts both as the source of neutrons and the heat

  7. TARGETING CANCER STEM CELLS Summary of technology

    E-Print Network [OSTI]

    Mucina, Ladislav

    TARGETING CANCER STEM CELLS Summary of technology Cancerstemcells(CSCs)playasignificantroleinleukemia, glioma, and breast, lung, gastrointestinal, prostate and ovarian cancer etiology, causing therapy of a new adjunct for targeted therapy of cancer involving CSCs, for use in combination with existing cancer

  8. Target Volatility Option Pricing Giuseppe Di Graziano

    E-Print Network [OSTI]

    Macrina, Andrea

    for the pricing of Target Volatility Options (TVOs), a recent market innovation in the eld of volatility are lower than the target volatility, the pay-o of the former is higher than the pay-o of the corresponding experi- enced a steep increase, with a signicant impact on option (long vega) costs. The generalized

  9. Technical Design Report, Second Target Station

    SciTech Connect (OSTI)

    Galambos, John D.; Anderson, David E.; Bechtol, D.; Bethea, Katie L.; Brown, N.; Carden, W. F.; Chae, Steven M.; Clark, A.; Counce, Deborah M.; Craft, K.; Crofford, Mark T.; Collins, Richard M.; Cousineau, Sarah M.; Curry, Douglas E.; Cutler, Roy I.; Dayton, Michael J.; Dean, Robert A.; Deibele, Craig E.; Doleans, Marc; Dye, T.; Eason, Bob H.; Eckroth, James A.; Fincrock, C.; Fritts, S.; Gallmeier, Franz X.; Gawne, Ken R.; Hartman, Steven M.; Herwig, Kenneth W.; Hess, S.; Holmes, Jeffrey A.; Horak, Charlie M.; Howell, Matthew P.; Iverson, Erik B.; Jacobs, Lorelei L.; Jones, Larry C.; Johnson, B.; Johnson, S.; Kasemir, Kay; Kim, Sang-Ho; Laughon, Gregory J.; Lu, W.; Mahoney, Kelly L.; Mammosser, John; McManamy, T.; Michilini, M.; Middendorf, Mark E.; O'Neal, Ed; Nemec, B.; Peters, Roy Cecil; Plum, Michael A.; Reagan, G.; Remec, Igor; Rennich, Mark J.; Riemer, Bernie; Saethre, Robert B.; Schubert, James Phillip; Shishlo, Andrei P.; Smith, C. Craig; Strong, William Herb; Tallant, Kathie M.; Tennant, David Alan; Thibadeau, Barbara M.; Trumble, S.; Trotter, Steven M.; Wang, Z.; Webb, Steven B.; Williams, Derrick C.; White, Karen S.; Zhao, Jinkui

    2015-01-01

    The Second Target Station (STS) is a proposed upgrade for SNS. It includes a doubling of the accelerator power and an additional instrument hall. The new instrument hall will receive a 467 kW 10 Hz beam. The parameters and preliminary design aspects of the STS are presented for the accelerator, target systems, instrument hall, instruments and civil construction aspects.

  10. Benchmarking and Evaluating Recongurable Architectures Targeting

    E-Print Network [OSTI]

    Luk, Wayne

    benchmarking suite that evaluates the power consumption of reconfigurable technology for applications targeting the mobile computing domain. This benchmark suite includes seven designs; one design targets fine-grained FPGA fabrics allowing for quick state- of-the-art evaluation, and six designs are specified at a high

  11. Untappable key distribution system: a one-time-pad booster

    E-Print Network [OSTI]

    Geraldo A. Barbosa; Jeroen van de Graaf

    2015-07-08

    One-time-pad (OTP) encryption simply cannot be cracked, even by a quantum computer. The need of sharing in a secure way supplies of symmetric random keys turned the method almost obsolete as a standing-alone method for fast and large volume telecommunication. Basically, this secure sharing of keys and their renewal, once exhausted, had to be done through couriers, in a slow and costly process. This paper presents a solution for this problem providing a fast and unlimited renewal of secure keys: An untappable key distribution system is presented and detailed. This fast key distribution system utilizes two layers of confidentially protection: 1) Physical noise intrinsic to the optical channel that turn the coded signals into stealth signals and 2) Privacy amplification using a bit pool of refreshed entropy run after run, to eliminate any residual information. The resulting level of security is rigorously calculated and demonstrates that the level of information an eavesdropper could obtain is completely negligible. The random bit sequences, fast and securely distributed, can be used to encrypt text, data or voice.

  12. Resistance proof, folding-inhibitor drugs

    E-Print Network [OSTI]

    R. Broglia; G. Tiana; R. Berera

    2002-10-09

    Conventional drugs work, as a rule, by inhibiting the enzymatic activity of specific proteins, capping their active site. In this paper we present a model of non- conventional drug design based on the inhibiting effects small peptides obtained from segments of the protein itself have on the folding ability of the system. Such peptides attach to the newly expressed (unfolded) protein and inhibit its folding, inhibition which cannot be avoided but through mutations which in any case denaturate the enzyme. These peptides, or their mimetic molecules, can be used as effective alternative drugs to those already available, displaying the advantage of not suffering from the upraise of resistence.

  13. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01

    International Journal of Drug Policy 10: 319-28. Zinberg,Norman E. 1984. Drug, Set, and Setting: The Basis forand Mirrors: The War on Drugs and the Politics of Failure.

  14. Flow cytometry aids basic cell biology research and drug discovery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Life Technologies Corporation and LANL have...

  15. Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug

    E-Print Network [OSTI]

    Hill, Wendell T.

    Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug's Nanotechnology Center are creating novel tools and developing new methods for crucial research areas of drug

  16. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein...

  17. Continuous Variable Quantum Key Distribution with a Noisy Laser

    E-Print Network [OSTI]

    Christian S. Jacobsen; Tobias Gehring; Ulrik L. Andersen

    2015-07-06

    Existing experimental implementations of continuous-variable quantum key distribution require shot-noise limited operation, achieved with shot-noise limited lasers. However, loosening this requirement on the laser source would allow for cheaper, potentially integrated systems. Here, we implement a theoretically proposed prepare-and-measure continuous-variable protocol and experimentally demonstrate the robustness of it against preparation noise stemming for instance from technical laser noise. Provided that direct reconciliation techniques are used in the post-processing we show that for small distances large amounts of preparation noise can be tolerated in contrast to reverse reconciliation where the key rate quickly drops to zero. Our experiment thereby demonstrates that quantum key distribution with non-shot-noise limited laser diodes might be feasible.

  18. Efficiency in Quantum Key Distribution Protocols with Entangled Gaussian States

    E-Print Network [OSTI]

    C. Rodó; O. Romero-Isart; K. Eckert; A. Sanpera

    2007-03-21

    Quantum key distribution (QKD) refers to specific quantum strategies which permit the secure distribution of a secret key between two parties that wish to communicate secretly. Quantum cryptography has proven unconditionally secure in ideal scenarios and has been successfully implemented using quantum states with finite (discrete) as well as infinite (continuous) degrees of freedom. Here, we analyze the efficiency of QKD protocols that use as a resource entangled gaussian states and gaussian operations only. In this framework, it has already been shown that QKD is possible (M. Navascu\\'es et al. Phys. Rev. Lett. 94, 010502 (2005)) but the issue of its efficiency has not been considered. We propose a figure of merit (the efficiency $E$) to quantify the number of classical correlated bits that can be used to distill a key from a sample of $N$ entangled states. We relate the efficiency of the protocol to the entanglement and purity of the states shared between the parties.

  19. Secret Key Generation via a Modified Quantum Secret Sharing Protocol

    SciTech Connect (OSTI)

    Smith IV, Amos M; Evans, Philip G; Lawrie, Benjamin J; Legre, Matthieu; Lougovski, Pavel; Ray, William R; Williams, Brian P; Qi, Bing; Grice, Warren P

    2015-01-01

    We present and experimentally show a novel protocol for distributing secret information between two and only two parties in a N-party single-qubit Quantum Secret Sharing (QSS) system. We demonstrate this new algorithm with N = 3 active parties over 6km of telecom. ber. Our experimental device is based on the Clavis2 Quantum Key Distribution (QKD) system built by ID Quantique but is generalizable to any implementation. We show that any two out of the N parties can build secret keys based on partial information from each other and with collaboration from the remaining N > 2 parties. This algorithm allows for the creation of two-party secret keys were standard QSS does not and signicantly reduces the number of resources needed to implement QKD on a highly connected network such as the electrical grid.

  20. Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile

    SciTech Connect (OSTI)

    Koenig, Xaver; Kovar, Michael; Rubi, Lena; Mike, Agnes K.; Lukacs, Peter; Gawali, Vaibhavkumar S.; Todt, Hannes [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Hilber, Karlheinz, E-mail: karlheinz.hilber@meduniwien.ac.at [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Sandtner, Walter [Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna (Austria)

    2013-12-01

    The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licenced as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Na{sub v}1.5 sodium and Ca{sub v}1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (? 10 ?M) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. - Highlights: • We study effects of anti-addiction drug ibogaine on ionic currents in cardiomyocytes. • We assess the cardiac ion channel profile of ibogaine. • Ibogaine inhibits hERG potassium, sodium and calcium channels. • Ibogaine’s effects on ion channels are a potential source of cardiac arrhythmias. • 18-Methoxycoronaridine has a lower affinity for cardiac ion channels than ibogaine.

  1. A Key to Common Caterpillar Pests of Vegetables 

    E-Print Network [OSTI]

    Sparks Jr., Alton N.; Liu, Tong-Xian

    2001-08-10

    of the head capsule. The proximity of the juncture of the adfrontal and epicranial sutures to the vertical triangle is used in separating armyworms and cutworms. Using the key The key will help you identify the most destructive and most com- mon caterpillar...; sp=spiracle Figure 3. Common arrangement of crochets on prolegs. A?complete circle B?semicircle C?two rows D?single row Figure 4. Head capsule of a caterpillar. vt=vertical triangle; epi=epicranial suture; adf=adfrontal suture 3 1 Body has numerous...

  2. Robust Shot Noise Measurement for Continuous Variable Quantum Key Distribution

    E-Print Network [OSTI]

    Sébastien Kunz-Jacques; Paul Jouguet

    2015-01-17

    We study a practical method to measure the shot noise in real time in Continuous Variable Quantum Key Distribution (CVQKD) systems. The amount of secret key that can be extracted from the raw statistics depends strongly on this quantity since it affects in particular the computation of the excess noise (i.e. noise in excess of the shot noise) added by an eavesdropper on the quantum channel. Some powerful quantum hacking attacks relying on faking the estimated value of the shot noise to hide an intercept and resend strategy were proposed. Here, we provide experimental evidence that our method can defeat the saturation attack and the wavelength attack.

  3. Feasibility of underwater free space quantum key distribution

    E-Print Network [OSTI]

    Peng Shi; Shi-Cheng Zhao; Wen-Dong Li; Yong-Jian Gu

    2014-04-04

    We investigate the optical absorption and scattering properties of underwater media pertinent to our underwater free space quantum key distribution (QKD) channel model. With the vector radiative transfer theory and Monte Carlo method, we obtain the attenuation of photons, the fidelity of the scattered photons, the quantum bit error rate and the sifted key generation rate of underwater quantum communication. It can be observed from our simulations that the most secure single photon underwater free space QKD is feasible in the clearest ocean water.

  4. Key Dates | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousand Cubic Feet) SoldDepartment ofKenThousandtheKevlarKeyKey

  5. The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds

    SciTech Connect (OSTI)

    Marks, Louise, E-mail: louise.marks@astrazeneca.com [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)] [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom); Borland, Samantha; Philp, Karen; Ewart, Lorna; Lainée, Pierre; Skinner, Matthew [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)] [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom); Kirk, Sarah [Innovative Medicines, Discovery Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)] [Innovative Medicines, Discovery Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom); Valentin, Jean-Pierre [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)] [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)

    2012-09-01

    Despite rigorous preclinical and clinical safety evaluation, adverse cardiac effects remain a leading cause of drug attrition and post-approval drug withdrawal. A number of cardiovascular screens exist within preclinical development. These screens do not, however, provide a thorough cardiac liability profile and, in many cases, are not preventing the progression of high risk compounds. We evaluated the suitability of the anaesthetised guinea-pig for the assessment of drug-induced changes in cardiovascular parameters. Sodium pentobarbitone anaesthetised male guinea-pigs received three 15 minute intravenous infusions of ascending doses of amoxicillin, atenolol, clonidine, dobutamine, dofetilide, flecainide, isoprenaline, levosimendan, milrinone, moxifloxacin, nifedipine, paracetamol, verapamil or vehicle, followed by a 30 minute washout. Dose levels were targeted to cover clinical exposure and above, with plasma samples obtained to evaluate effect/exposure relationships. Arterial blood pressure, heart rate, contractility function (left ventricular dP/dt{sub max} and QA interval) and lead II electrocardiogram were recorded throughout. In general, the expected reference compound induced effects on haemodynamic, contractility and electrocardiographic parameters were detected confirming that all three endpoints can be measured accurately and simultaneously in one small animal. Plasma exposures obtained were within, or close to the expected clinical range of therapeutic plasma levels. Concentration–effect curves were produced which allowed a more complete understanding of the margins for effects at different plasma exposures. This single in vivo screen provides a significant amount of information pertaining to the cardiovascular risk of drug candidates, ultimately strengthening strategies addressing cardiovascular-mediated compound attrition and drug withdrawal. -- Highlights: ? Evaluation of the anaesthetised guinea-pig to determine cardiac liability. ? Haemodynamic, contractility, ECG parameters and plasma exposure all measurable. ? Single small animal model offering extensive evaluation of a drug's CV risk. ? Potential to strengthen drug discovery cardiovascular strategy. ? Potential to halt progression of drugs with CV liability, reducing drug attrition.

  6. In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27

    SciTech Connect (OSTI)

    Acosta-Reyes, Francisco J. [Universitat Politécnica de Catalunya, Diagonal 647, 08028 Barcelona (Spain); Dardonville, Christophe [Instituto de Química Médica, IQM–CSIC, Juan de la Cierva 3, 28006 Madrid (Spain); Koning, Harry P. de; Natto, Manal [University of Glasgow, 120 University Place, Glasgow G12 8TA, Scotland (United Kingdom); Subirana, Juan A.; Campos, J. Lourdes, E-mail: lourdes.campos@upc.edu [Universitat Politécnica de Catalunya, Diagonal 647, 08028 Barcelona (Spain)

    2014-06-01

    New features of an antiprotozoal DNA minor-groove binding drug, which acts as a cross-linking agent, are presented. It also fills the minor groove of DNA completely and prevents the access of proteins. These features are also expected for other minor-groove binding drugs when associated with suitable DNA targets. The DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies of drugs which interact with the minor groove of DNA, some of which are used in medical practice. Previous studies have been performed almost exclusively with the AATT sequence. New features should be uncovered through the study of different DNA sequences. In this paper, the crystal structure of the complex of the DNA duplex d(AAAATTTT){sub 2} with the dicationic drug 4, 4?-bis(imidazolinylamino)diphenylamine (CD27) is presented. The drug binds to the minor groove of DNA as expected, but it shows two new features that have not previously been described: (i) the drugs protrude from the DNA and interact with neighbouring molecules, so that they may act as cross-linking agents, and (ii) the drugs completely cover the whole minor groove of DNA and displace bound water. Thus, they may prevent the access to DNA of proteins such as AT-hook proteins. These features are also expected for other minor-groove binding drugs when associated with all-AT DNA. These findings allow a better understanding of this family of compounds and will help in the development of new, more effective drugs. New data on the biological interaction of CD27 with the causative agent of trichomoniasis, Trichomonas vaginalis, are also reported.

  7. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  8. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  9. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01

    Drugs (ESSPAOD). 2003. The ESPAD Report 2003: Alcohol andModintryckoffset. http://www.espad.org/documents/Espad/ESPAD_reports/The_2003_ESPAD_report.pdf. Fainaru, Steve, and

  10. NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM

    E-Print Network [OSTI]

    Hart, Steven N.

    2011-02-22

    Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

  11. Micro-fabrication Techniques for Target Components

    SciTech Connect (OSTI)

    Miles, R; Hamilton, J; Crawford, J; Ratti, S; Trevino, J; Graff, T; Stockton, C; Harvey, C

    2008-06-10

    Micro-fabrication techniques, derived from the semi-conductor industry, can be used to make a variety of useful mechanical components for targets. A selection of these components including supporting cooling arms for prototype cryogenic inertial confinement fusion targets, stepped and graded density targets for materials dynamics experiments are described. Micro-fabrication enables cost-effective, simultaneous fabrication of multiple high-precision components with complex geometries. Micro-fabrication techniques such as thin-film deposition, photo-lithographic patterning and etch processes normally used in the semi-conductor manufacture industry, can be exploited to make useful mechanical target components. Micro-fabrication processes have in recent years been used to create a number of micro-electro-mechanical systems (MEMS) components such as pressure sensors, accelerometers, ink jet printer heads, microfluidics platforms and the like. These techniques consist primarily of deposition of thin films of material, photo-lithographic patterning and etching processes performed sequentially to produce three dimensional structures using essentially planar processes. While the planar technology can be limiting in terms of the possible geometries of the final product, advantages of using these techniques include the ability to make multiple complex structures simultaneously and cost-effectively. Target components fabricated using these techniques include the supporting cooling arms for cryogenic prototype fusion ignition targets, stepped targets for equation-of-state experiments, and graded density reservoirs for material strength experiments.

  12. Protein search for multiple targets on DNA

    E-Print Network [OSTI]

    Martin Lange; Maria Kochugaeva; Anatoly B. Kolomeisky

    2015-08-03

    Protein-DNA interactions are crucial for all biological processes. One of the most important fundamental aspects of these interactions is the process of protein searching and recognizing specific binding sites on DNA. A large number of experimental and theoretical investigations have been devoted to uncovering the molecular description of these phenomena, but many aspects of the mechanisms of protein search for the targets on DNA remain not well understood. One of the most intriguing problems is the role of multiple targets in protein search dynamics. Using a recently developed theoretical framework we analyze this question in detail. Our method is based on a discrete-state stochastic approach that takes into account most relevant physical-chemical processes and leads to fully analytical description of all dynamic properties. Specifically, systems with two and three targets have been explicitly investigated. It is found that multiple targets in most cases accelerate the search in comparison with a single target situation. However, the acceleration is not always proportional to the number of targets. Surprisingly, there are even situations when it takes longer to find one of the multiple targets in comparison with the single target. It depends on the spatial position of the targets, distances between them, average scanning lengths of protein molecules on DNA, and the total DNA lengths. Physical-chemical explanations of observed results are presented. Our predictions are compared with experimental observations as well as with results from a continuum theory for the protein search. Extensive Monte Carlo computer simulations fully support our theoretical calculations.

  13. A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human

    SciTech Connect (OSTI)

    Poulin, Patrick, E-mail: patrick-poulin@videotron.ca [Quebec City, Quebec (Canada); Ekins, Sean [Collaborations in Chemistry, 601 Runnymede Avenue, Jenkintown, PA 19046 (United States); Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, MD 21201 (United States); Department of Pharmacology, University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854 (United States); Theil, Frank-Peter [Genentech, South San Francisco (United States)

    2011-01-15

    A general toxicity of basic drugs is related to phospholipidosis in tissues. Therefore, it is essential to predict the tissue distribution of basic drugs to facilitate an initial estimate of that toxicity. The objective of the present study was to further assess the original prediction method that consisted of using the binding to red blood cells measured in vitro for the unbound drug (RBCu) as a surrogate for tissue distribution, by correlating it to unbound tissue:plasma partition coefficients (Kpu) of several tissues, and finally to predict volume of distribution at steady-state (V{sub ss}) in humans under in vivo conditions. This correlation method demonstrated inaccurate predictions of V{sub ss} for particular basic drugs that did not follow the original correlation principle. Therefore, the novelty of this study is to provide clarity on the actual hypotheses to identify i) the impact of pharmacological mode of action on the generic correlation of RBCu-Kpu, ii) additional mechanisms of tissue distribution for the outlier drugs, iii) molecular features and properties that differentiate compounds as outliers in the original correlation analysis in order to facilitate its applicability domain alongside the properties already used so far, and finally iv) to present a novel and refined correlation method that is superior to what has been previously published for the prediction of human V{sub ss} of basic drugs. Applying a refined correlation method after identifying outliers would facilitate the prediction of more accurate distribution parameters as key inputs used in physiologically based pharmacokinetic (PBPK) and phospholipidosis models.

  14. ESO Imaging Survey: Finding Targets for VLT

    E-Print Network [OSTI]

    L. N. da Costa

    1998-09-16

    Data from the wide-angle, moderately deep ESO Imaging Survey have been used to produce target lists for the first year of the VLT. About 250 candidate clusters of galaxies have been identified from the I-band images covering $\\sim$ 17 square degrees. In addition, using the multicolor data available over an area of 1.3 square degrees over 300 potentially interesting point-sources have been selected. The color-selected targets include low-mass stars/brown dwarfs, white-dwarfs and quasars. Images, object catalogs and derived target lists are available from the world-wide web (http://www.eso.org/eis)

  15. Targeting engineering synchronization in chaotic systems

    E-Print Network [OSTI]

    Sourav K. Bhowmick; Dibakar Ghosh

    2015-06-14

    A method of targeting engineering synchronization states in two identical and mismatch chaotic systems is explained in details. The method is proposed using linear feedback controller coupling for engineering synchronization such as mixed synchronization, linear and nonlinear generalized synchronization and targeting fixed point. The general form of coupling design to target any desire synchronization state under unidirectional coupling with the help of Lyapunov function stability theory is derived analytically. A scaling factor is introduced in the coupling definition to smooth control without any loss of synchrony. Numerical results are done on two mismatch Lorenz systems and two identical Sprott oscillators.

  16. Diagnostics for High Power Targets and Dumps

    E-Print Network [OSTI]

    Gschwendtner, E

    2012-01-01

    High power targets are generally used for neutrino, antiproton, neutron and secondary beam production whereas dumps are needed in beam waste management. In order to guarantee an optimized and safe use of these targets and dumps, reliable instrumentation is needed; the diagnostics in high power beams around targets and dumps is reviewed. The suite of beam diagnostics devices used in such extreme environments is discussed, including their role in commissioning and operation. The handling and maintenance of the instrumentation components in high radiation areas is also addressed.

  17. Self-assessing target with automatic feedback

    DOE Patents [OSTI]

    Larkin, Stephen W.; Kramer, Robert L.

    2004-03-02

    A self assessing target with four quadrants and a method of use thereof. Each quadrant containing possible causes for why shots are going into that particular quadrant rather than the center mass of the target. Each possible cause is followed by a solution intended to help the marksman correct the problem causing the marksman to shoot in that particular area. In addition, the self assessing target contains possible causes for general shooting errors and solutions to the causes of the general shooting error. The automatic feedback with instant suggestions and corrections enables the shooter to improve their marksmanship.

  18. Dictionaries Using Variable-Length Keys and Data, with Applications *

    E-Print Network [OSTI]

    Blelloch, Guy E.

    (Isil- logn, 1) + Itil) and Isil is the length of bit string si. We assume a word length w > log m. We present string Isil > 1, Itil > 1 for all bit-strings si and ti. Fox' fixed-length keys the dictionary problem

  19. Key Factors for Digital Collections August 7, 2007

    E-Print Network [OSTI]

    by Fondren's Digital Library Initiative We evaluate digital projects on a case by case basis. There is no oneKey Factors for Digital Collections August 7, 2007 Rice University Digital Repository Supported formula for this process and in fact welcome open discussion on potential digital projects

  20. Automation-considered Logic of Authentication and Key Distribution

    E-Print Network [OSTI]

    Kwon, Taekyoung

    methods are focused on the automation-based model checking that relies on building a finite modelAutomation-considered Logic of Authentication and Key Distribution Taekyoung Kwon1 and Seongan Lim2 Abstract. This paper presents an automation-considered logic of au- thentication for reasoning about

  1. Offshore Wind Power Experiences, Potential and Key Issues for

    E-Print Network [OSTI]

    offshore wind farms are installed in British, Swedish and Danish waters, and present-day costs in 2015, 2030 and 2050 14 3.1 Offshore wind farms under construction and in planning stage 14 3Offshore Wind Power Experiences, Potential and Key Issues for Deployment Jørgen Lemming, Poul Erik

  2. Architecture of the Secoqc Quantum Key Distribution network

    E-Print Network [OSTI]

    Mehrdad Dianati; Romain Alleaume

    2006-10-25

    The European projet Secoqc (Secure Communication based on Quantum Cryptography) aims at developing a global network for unconditionally secure key distribution. This paper specifies the requirements and presents the principles guiding the design of this network, and relevant to its architecture and protocols.

  3. The Key Coal Producers ONLINE SUPPORTING MATERIALS to

    E-Print Network [OSTI]

    Patzek, Tadeusz W.

    The Key Coal Producers ONLINE SUPPORTING MATERIALS to A Global Coal Production Forecast with Multi's most important coal-producing area is North-Central China. The provinces of Inner Mongolia, Ningxia, Shaanxi and Shanxi together accounted for 83 percent of China's proven coal reserves in 2000, and Shanxi

  4. Preparing Turkey Safely Turkey provides protein along with other key

    E-Print Network [OSTI]

    Preparing Turkey Safely Nutrition Turkey provides protein along with other key nutrients. A serving is 3 ounces cooked poultry (about the size of a deck of cards). One serving of roasted, skinless turkey protein; iron--8% daily value Right Size Turkey Use this chart as a helpful guide: Whole bird ­ 1 pound

  5. PEM FUEL CELL TECHNOLOGY Key Research Needs and Approaches

    E-Print Network [OSTI]

    Developer University #12;8 FUEL CELL RESEARCH NEEDS MEA optimization should focus on new materials Pt (full1 PEM FUEL CELL TECHNOLOGY Key Research Needs and Approaches Tom Jarvi UTC Power South Windsor, CT 06074 23 January 2008 #12;2 UTC POWER MARKET FOCUS Transportation Fuel Cells On-Site Power Solutions #12

  6. GIS and Spectral Soil Laboratory Key faculty member: Sabine Grunwald

    E-Print Network [OSTI]

    Ma, Lena

    GIS and Spectral Soil Laboratory Key faculty member: Sabine Grunwald Contact: Soil and Water information systems (GIS), geostatistical and statistical methods, space-time landscape modeling, remote laboratory. Available software include: MS Office Suite; MS SQL database; ArcGIS Suite (ESRI) including

  7. November 2012 Key Performance Indicator (KPI): Carbon Management

    E-Print Network [OSTI]

    Evans, Paul

    November 2012 Key Performance Indicator (KPI): Carbon Management NTU report our carbon footprint provided. The carbon emissions are calculated using Carbon Trust conversion factors, as used in NTU's EMS.64 2011/2012 18,130 4.20 The recorded changes in emissions are a result of carbon management projects

  8. Experimental quantum key distribution with proven security against realistic attacks

    E-Print Network [OSTI]

    Salvail, Louis

    , center of the Danish National Research Foundation, Dept. of Computer Science,University of Aarhus,8000, Denmark Abstract We report on a realization of a fully automated 20 km quantum key distribution system­ cated security analysis against realistic attacks is used to optimize the system parameters in order

  9. Experimental quantum key distribution without monitoring signal disturbance

    E-Print Network [OSTI]

    Hiroki Takesue; Toshihiko Sasaki; Kiyoshi Tamaki; Masato Koashi

    2015-05-29

    Since the invention of Bennett-Brassard 1984 (BB84) protocol, many quantum key distribution (QKD) protocols have been proposed and some protocols are operated even in field environments. One of the striking features of QKD is that QKD protocols are provably secure unlike cryptography based on computational complexity assumptions. It has been believed that, to guarantee the security of QKD, Alice and Bob have to monitor the statistics of the measurement outcomes which are used to determine the amount of the privacy amplification to generate a key. Recently a new type of QKD protocol, called round robin differential phase shift (RRDPS) protocol, was proposed, and remarkably this protocol can generate a key without monitoring any statistics of the measurement outcomes. Here we report an experimental realization of the RRDPS protocol. We used a setup in which Bob randomly chooses one from four interferometers with different pulse delays so that he could implement phase difference measurements for all possible combinations with five-pulse time-bin states. Using the setup, we successfully distributed keys over 30 km of fiber, making this the first QKD experiment that does not rely on signal disturbance monitoring.

  10. The Seven Keys to Success in Energy Management and Conservation 

    E-Print Network [OSTI]

    Darby, D. F.

    1984-01-01

    This paper is a summary of the seven key elements of the Deere & Company Energy Management and Conservation Program. These elements have been found to be essential for the ultimate success of any company-wide energy management program. The process...

  11. FAST GENERATORS FOR THE DIFFIEHELLMAN KEY AGREEMENT PROTOCOL

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    FAST GENERATORS FOR THE DIFFIE­HELLMAN KEY AGREEMENT PROTOCOL AND MALICIOUS STANDARDS BOAZ TSABAN­order cyclic group. Some generators allow faster exponentiation. We show that to a large extent, using the fast that if there is some case in which fast generators are less secure, then this could be used by a malicious authority

  12. FAST GENERATORS FOR THE DIFFIE-HELLMAN KEY AGREEMENT PROTOCOL

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    FAST GENERATORS FOR THE DIFFIE-HELLMAN KEY AGREEMENT PROTOCOL AND MALICIOUS STANDARDS BOAZ TSABAN, using the fast generators is as secure as using a randomly chosen generator. On the other hand, we show that if there is some case in which fast generators are less secure, then this could be used by a malicious authority

  13. Appendix 30 Fire Effects on Key Ecological Processes in Forested

    E-Print Network [OSTI]

    Appendix 30 Fire Effects on Key Ecological Processes in Forested Ecosystems The following paragraphs on fire effects on forest succession are from Stickney (1982) Forest Succession ...the severity of the pre-disturbance forest herb species also demonstrated the ability to survive fire, particularly those

  14. Outline Overview Design Principles Key Points Design Principles

    E-Print Network [OSTI]

    Almulhem, Ahmad

    Engineering Department, KFUPM Spring 2008 Ahmad Almulhem - Network Security Engineering - 2008 1 / 12 #12-Safe Defaults Economy of Mechanism Complete Mediation Open Design Separation of Privilege Least Common Mechanism Psychological Acceptability 3 Key Points Ahmad Almulhem - Network Security Engineering - 2008 2 / 12 #12;Outline

  15. Annual Report 2004 1 Key events during 2004

    E-Print Network [OSTI]

    Svenningsson, Josef

    Johansson studying the separation of carbon dioxide in a reactor system for two-stage combustion. #12;1 Key for innovation systems and entrepreneurship A year of anniversaries ­ the University, the Foundation, Chalmers are among those hardest struck,but many holidaying Swedes,especially in Thailand,fall victim to the tsunami

  16. MOLECULAR ENTOMOLOGY Molecular Identification Key for Pest Species of Scirtothrips

    E-Print Network [OSTI]

    Hoddle, Mark S.

    primers and determining the size of the products by using standard agarose gel electrophoresis, followed, Neohydatothrips, molecular identiÞcation key, exotic pests, nondestruc- tive DNA extraction The genus Scirtothrips, several species of Scirtothrips have (or have the potential to) spread from their natural habitats

  17. Introduction Adhesion complexes play key roles in many events, including

    E-Print Network [OSTI]

    Hardin, Jeff

    Introduction Adhesion complexes play key roles in many events, including cell migration cell adhesion are remarkably similar in Caenorhabditis elegans, Drosophila and humans (Hynes and Zhao to reveal much about the basic, conserved molecular mechanisms that mediate and regulate cell adhesion

  18. Keys for growth in Japan's mature mobile market

    E-Print Network [OSTI]

    Oto, Hiroyuki

    2005-01-01

    The objective of this thesis is to identify key factors that will produce further growth for NTT DoCoMo in Japan's mature mobile market. Since the early 1990s, the mobile phone market in Japan has grown rapidly, and ...

  19. Page 1 of 4 Creating and Submitting a Key Request

    E-Print Network [OSTI]

    Howitt, Ivan

    of employees. Enter search criteria in the search fields available and select the down red arrow to filter the terms. #12;Page 3 of 4 13. On the Key Request Form - Room List windowpane, select Add New. 14 use the Select Drawing button after entering the building and floor to display the floor plan

  20. news and views A key issue for hydrogen storage materi-

    E-Print Network [OSTI]

    Palumbi, Stephen

    news and views A key issue for hydrogen storage materi- als is that the hydrogenation and dehydro be possible to discover stable hydrogen hydrates with higher storage Hydrogen Posture Plan www.eere.energy.gov/hydrogenandfuelcells/pdfs/ hydrogen_posture_plan.pdf 7. Kuhs, W

  1. Key Directions and a Roadmap for Electrical Design for Manufacturability

    E-Print Network [OSTI]

    Kahng, Andrew B.

    Key Directions and a Roadmap for Electrical Design for Manufacturability (Invited Talk) Andrew B by design and design-for- manufacturability (DFM) techniques. This talk addresses trends and a roadmap assumptions come true? The second part will give a roadmap for electrical DFM technologies, motivated

  2. Key Title Marine Ecology www.wiley.com

    E-Print Network [OSTI]

    Wall, Diana

    Key Title Marine Ecology www.wiley.com Antarctic Ecosystems: An Extreme Environment in a Changing their genomes. Chapters address both Antarctic terrestrial and marine ecosystems, and the scientific and evolution Part II: Marine habitats and regions Chapter 4. The impact of regional climate change

  3. Key Facts About Hurricane Readiness Preparing for a Hurricane

    E-Print Network [OSTI]

    HURRICANES Key Facts About Hurricane Readiness Preparing for a Hurricane If you are under a hurricane watch or warning, here are some basic steps to take to prepare for the storm: · Learn about your. · Identify potential home hazards and know how to secure or protect them before the hurricane strikes

  4. Notes on the CRTDH Group Key Agreement Protocol Spyros Magliveras and Wandi Wei

    E-Print Network [OSTI]

    Magliveras, Spyros

    , the distributed schemes help in the uniform distribution of the work-load for key management and eliminate: xkzou@cs.iupui.edu Abstract Group key management (GKM) is one of the primary is- sues for secure group Key Management (GKM), Contributory Group Key Agreement, Chinese Remainder Theorem, Diffie-Hellman Key

  5. Nanotechnology-mediated targeting of tumor angiogenesis

    E-Print Network [OSTI]

    Banerjee, Deboshri

    Abstract Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging strategy for the development of therapies targeting tumor-associated angiogenesis is to harness the potential of nanotechnology ...

  6. Webinar: Targeted Algal Biofuels and Bioproducts FOA

    Broader source: Energy.gov [DOE]

    The Energy Department’s Bioenergy Technologies Office will present a live informational webcast on the Targeted Algal Biomass and Bioproducts Funding Opportunity (DE-FOA-0001162) on October 8, 2014...

  7. Tagging and Targeting of Energy Efficiency Subsidies

    E-Print Network [OSTI]

    Allcott, Hunt

    A corrective tax or subsidy is "well-targeted" if it primarily affects choices that are more distorted by market failures. Energy efficiency subsidies are designed to correct multiple distortions: externalities, credit ...

  8. Statistical Modeling of Single Target Cell Encapsulation

    E-Print Network [OSTI]

    Moon, SangJun

    High throughput drop-on-demand systems for separation and encapsulation of individual target cells from heterogeneous mixtures of multiple cell types is an emerging method in biotechnology that has broad applications in ...

  9. Improved Gene Targeting through Cell Cycle Synchronization

    E-Print Network [OSTI]

    Tsakraklides, Vasiliki

    Gene targeting is a challenge in organisms where non-homologous end-joining is the predominant form of recombination. We show that cell division cycle synchronization can be applied to significantly increase the rate of ...

  10. Targeting cancer metabolism: a therapeutic window opens

    E-Print Network [OSTI]

    Vander Heiden, Matthew G.

    Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

  11. Analysis of Climate Policy Targets under Uncertainty

    E-Print Network [OSTI]

    Jacoby, Henry D.

    Although policymaking in response to the climate change is essentially a challenge of risk management, most studies of the relation of emissions targets to desired climate outcomes are either deterministic or subject to a ...

  12. Improving Targeted Radionuclide Therapy Using Nuclear Nanotechnology 

    E-Print Network [OSTI]

    Evans, Jordan Andrew

    2013-05-03

    The objectives of this thesis are to produce radioactive antibody-conjugated gold nanoparticles to improve the efficacy of targeted radionuclide therapy for the treatment of cancer, and to demonstrate that this product can be produced at Texas A...

  13. Method and apparatus for producing cryogenic targets

    DOE Patents [OSTI]

    Murphy, James T. (Los Alamos, NM); Miller, John R. (Penfield, NY)

    1984-01-01

    An improved method and apparatus are given for producing cryogenic inertially driven fusion targets in the fast isothermal freezing (FIF) method. Improved coupling efficiency and greater availability of volume near the target for diagnostic purposes and for fusion driver beam propagation result. Other embodiments include a new electrical switch and a new explosive detonator, all embodiments making use of a purposeful heating by means of optical fibers.

  14. Method and apparatus for producing cryogenic targets

    DOE Patents [OSTI]

    Murphy, J.T.; Miller, J.R.

    1984-08-07

    An improved method and apparatus are given for producing cryogenic inertially driven fusion targets in the fast isothermal freezing (FIF) method. Improved coupling efficiency and greater availability of volume near the target for diagnostic purposes and for fusion driver beam propagation result. Other embodiments include a new electrical switch and a new explosive detonator, all embodiments making use of a purposeful heating by means of optical fibers. 6 figs.

  15. Cryostat including heater to heat a target

    DOE Patents [OSTI]

    Pehl, R.H.; Madden, N.W.; Malone, D.F.

    1990-09-11

    A cryostat is provided which comprises a vacuum vessel; a target disposed within the vacuum vessel; a heat sink disposed within the vacuum vessel for absorbing heat from the detector; a cooling mechanism for cooling the heat sink; a cryoabsorption mechanism for cryoabsorbing residual gas within the vacuum vessel; and a heater for maintaining the target above a temperature at which the residual gas is cryoabsorbed in the course of cryoabsorption of the residual gas by the cryoabsorption mechanism. 2 figs.

  16. Current status of the liquid lithium target

    E-Print Network [OSTI]

    McDonald, Kirk

    in target (mm) 252 x 125Maximum beam current (mA) ~1~10~100Beam spot on the target (cm2) >2 (peak)0.52.5Beam Water direction #12;15 Be Trap Heat Exchanger Cross Section Design to remove ~12 kW Lithium tank #12;Oil cycle Flexible tubes Oil pump Heat exchanger Oil chamber Inside the lab Outside the lab #12;Elect

  17. February 2011 1906: Pure Food & Drugs Act regulated

    E-Print Network [OSTI]

    Arslan, Hüseyin

    February 2011 #12; 1906: Pure Food & Drugs Act ­ regulated adultered/misbranded food & drugs 1938: Food, Drugs, & Cosmetics Acts ­ required premarket review for safety 1962: FDCA Amendments ­ the birth for investigations of new drugs, including a requirement for informed consent #12; 21 CFR 312 Subpart A ­ general

  18. Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer

    DOE Patents [OSTI]

    Hu, Zhi (El Cerrito, CA); Kuo, Wen-Lin (San Ramon, CA); Neve, Richard M. (San Mateo, CA); Gray, Joe W. (San Francisco, CA)

    2012-06-12

    Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.

  19. A Mathematical Tumor Model with Immune Resistance and Drug Therapy: An Optimal Control Approach

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    De Pillis, L. G.; Radunskaya, A.

    2001-01-01

    We present a competition model of cancer tumor growth that includes both the immune system response and drug therapy. This is a four-population model that includes tumor cells, host cells, immune cells, and drug interaction. We analyze the stability of the drug-free equilibria with respect to the immune response in order to look for target basins of attraction. One of our goals was to simulate qualitatively the asynchronous tumor-drug interaction known as “Jeffs phenomenon.” The model we develop is successful in generating this asynchronous response behavior. Our other goal was to identify treatment protocols that could improve standard pulsed chemotherapymore »regimens. Using optimal control theory with constraints and numerical simulations, we obtain new therapy protocols that we then compare with traditional pulsed periodic treatment. The optimal control generated therapies produce larger oscillations in the tumor population over time. However, by the end of the treatment period, total tumor size is smaller than that achieved through traditional pulsed therapy, and the normal cell population suffers nearly no oscillations.« less

  20. Design of the EURISOL multi-MW target assembly radiation and safety issues

    E-Print Network [OSTI]

    Felcini, Marta; Kadi, Yacine; Otto, Thomas; Tecchio, L

    2006-01-01

    The multi-MW target proposed for the EURISOL facility will be based on fission of uranium (or thorium) compounds to produce rare isotopes far from stability. A two-step process is used for the isotope production. First, neutrons are generated in a liquid mercury target, irradiated by the 1 GeV proton or deuteron beam, provided by the EURISOL linac driver. Then, the neutrons induce fission in a surrounding assembly of uranium carbide. R&D projects on several aspects of the target assembly are ongoing. Key criteria for the target design are a maximum beam power capability of 4 MW, a remote handling system with minimum downtime and maximum reliability, as well as radiation safety, minimization of hazards and the classification of the facility. In the framework of the ongoing radiation characterization and safety studies, radiation transport simulations have been performed to calculate the prompt radiation dose in the target and surrounding materials, as well as to determine shielding material and angle-depen...

  1. Design of the EURISOL multi-MW target assembly: radiation and safety issues

    E-Print Network [OSTI]

    Felcini, M; Kadi, Y; Otto, T; Tecchio, L; Otto, Th.

    2006-01-01

    The multi-MW target proposed for the EURISOL facility will be based on fission of uranium (or thorium) compounds to produce rare isotopes far from stability. A two-step process is used for the isotope production. First, neutrons are generated in a liquid mercury target, irradiated by the 1 GeV proton or deuteron beam, provided by the EURISOL linac driver. Then, the neutrons induce fission in a surrounding assembly of uranium carbide. R&D projects on several aspects of the target assembly are ongoing. Key criteria for the target design are a maximum beam power capability of 4 MW, a remote handling system with minimum downtime and maximum reliability, as well as radiation safety, minimization of hazards and the classification of the facility. In the framework of the ongoing radiation characterization and safety studies, radiation transport simulations have been performed to calculate the prompt radiation dose in the target and surrounding materials, as well as to determine shielding material and angle-depen...

  2. Distribution and abundance of endangered Florida Key deer on outer islands 

    E-Print Network [OSTI]

    Watts, Dominque Elijah

    2007-04-25

    -based survey data. All outer islands exhibited estimated abundances considerably below carrying capacities, with larger populations occurring closer to Big Pine Key. Results indicated that other islands and complexes such as Ramrod Key, Water Key...

  3. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  4. Mar. Drugs 2015, 13, 3154-3181; doi:10.3390/md13053154 marine drugs

    E-Print Network [OSTI]

    Paré, Paul W.

    Mar. Drugs 2015, 13, 3154-3181; doi:10.3390/md13053154 marine drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine Invertebrates Mohamed Costantino Received: 9 April 2015 / Accepted: 7 May 2015 / Published: 20 May 2015 Abstract: Marine

  5. Mar. Drugs 2013, 11, 4370-4389; doi:10.3390/md11114370 marine drugs

    E-Print Network [OSTI]

    Eirin Lopez, Jose Maria

    Mar. Drugs 2013, 11, 4370-4389; doi:10.3390/md11114370 marine drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review Bivalve Omics: State of the Art and Potential Applications for the Biomonitoring of Harmful Marine of the marine ecosystem, constitute very valuable commercial resources in aquaculture, and have been widely used

  6. Drug Free Workplace This notice is intended to meet the requirements of the Drug Free Workplace Act of 1988,

    E-Print Network [OSTI]

    Nicholson, Bruce J.

    Drug Free Workplace This notice is intended to meet the requirements of the Drug Free Workplace Act of 1988, United States Code Title 41, Chapter 81, and the Drug Free Schools and Communities Act Amendments revision date of September 1, 2016. Notice In accordance with the Drug Free Schools and Communities Act

  7. Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery to the Inner Ear by

    E-Print Network [OSTI]

    Salt, Alec N.

    1 Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery.Plontke@uni-tuebingen.de Although there is increasing interest in the local delivery of drugs to the inner ear by applying them to the round window (RW) membrane, most drug application protocols have been empirically- based. As a result

  8. Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing

    E-Print Network [OSTI]

    Gates, Kent. S.

    CHEM 4170 Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing assignment, this is a literature research project. The data for your drug will be presented below. Do not choose a drug that has been discussed in detail in Silverman's Book or in class. You may

  9. Simple rate-adaptive LDPC coding for quantum key distribution

    E-Print Network [OSTI]

    Mo Li; Chun-Mei Zhang; Zhen-Qiang Yin; Wei Chen; Chuan Wang; Zheng-Fu Han

    2015-05-24

    Although quantum key distribution (QKD) comes from the development of quantum theory, the implementation of a practical QKD system does involve a lot of classical process, such as key reconciliation and privacy amplification, which is called post-processing. Post-processing has been a crucial element to high speed QKD systems, even the bottleneck of it because of its relatively high time consumption. Low density parity check (LDPC) is now becoming a promising approach of overcoming the bottleneck due to its good performance in processing throughput. In this article we propose and simulate an easily implemented but efficiently rate-adaptive LDPC coding approach of reconciliation, different from the previously proposed puncturing- and shortening-based approach. We also give a measure for choosing the optimal LDPC parameter for our rate-adaptive approach according to error rates.

  10. Quantum Hacking on Quantum Key Distribution using Homodyne Detection

    E-Print Network [OSTI]

    Jing-Zheng Huang; Sébastien Kunz-Jacques; Paul Jouguet; Christian Weedbrook; Zhen-Qiang Yin; Shuang Wang; Wei Chen; Guang-Can Guo; Zheng-Fu Han

    2014-02-27

    Imperfect devices in commercial quantum key distribution systems open security loopholes that an eavesdropper may exploit. An example of one such imperfection is the wavelength dependent coupling ratio of the fiber beam splitter. Utilizing this loophole, the eavesdropper can vary the transmittances of the fiber beam splitter at the receiver's side by inserting lights with wavelengths different from what is normally used. Here, we propose a wavelength attack on a practical continuous-variable quantum key distribution system using homodyne detection. By inserting light pulses at different wavelengths, this attack allows the eavesdropper to bias the shot noise estimation even if it is done in real time. Based on experimental data, we discuss the feasibility of this attack and suggest a prevention scheme by improving the previously proposed countermeasures.

  11. No-signaling Quantum Key Distribution: Solution by Linear Programming

    E-Print Network [OSTI]

    Won-Young Hwang; Joonwoo Bae; Nathan Killoran

    2013-01-15

    We outline a straightforward approach for obtaining a secret key rate using only no-signaling constraints and linear programming. Assuming an individual attack, we consider all possible joint probabilities. Initially, we study only the case where Eve has binary outcomes, and we impose constraints due to the no-signaling principle and given measurement outcomes. Within the remaining space of joint probabilities, by using linear programming, we get bound on the probability of Eve correctly guessing Bob's bit. We then make use of an inequality that relates this guessing probability to the mutual information between Bob and a more general Eve, who is not binary-restricted. Putting our computed bound together with the Csisz\\'ar-K\\"orner formula, we obtain a positive key generation rate. The optimal value of this rate agrees with known results, but was calculated in a more straightforward way, offering the potential of generalization to different scenarios.

  12. Secure password-based authenticated key exchange for web services

    SciTech Connect (OSTI)

    Liang, Fang; Meder, Samuel; Chevassut, Olivier; Siebenlist, Frank

    2004-11-22

    This paper discusses an implementation of an authenticated key-exchange method rendered on message primitives defined in the WS-Trust and WS-SecureConversation specifications. This IEEE-specified cryptographic method (AuthA) is proven-secure for password-based authentication and key exchange, while the WS-Trust and WS-Secure Conversation are emerging Web Services Security specifications that extend the WS-Security specification. A prototype of the presented protocol is integrated in the WSRF-compliant Globus Toolkit V4. Further hardening of the implementation is expected to result in a version that will be shipped with future Globus Toolkit releases. This could help to address the current unavailability of decent shared-secret-based authentication options in the Web Services and Grid world. Future work will be to integrate One-Time-Password (OTP) features in the authentication protocol.

  13. Fast ignition of inertial confinement fusion targets

    SciTech Connect (OSTI)

    Gus'kov, S. Yu., E-mail: guskov@sci.lebedev.ru [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation)

    2013-01-15

    Results of studies on fast ignition of inertial confinement fusion (ICF) targets are reviewed. The aspects of the fast ignition concept, which consists in the separation of the processes of target ignition and compression due to the synchronized action of different energy drivers, are considered. Criteria for the compression ratio and heating rate of a fast ignition target, the energy balance, and the thermonuclear gain are discussed. The results of experimental and theoretical studies of the heating of a compressed target by various types of igniting drivers, namely, beams of fast electrons and light ions produced under the action of a petawatt laser pulse on the target, a heavy-ion beam generated in the accelerator, an X-ray pulse, and a hydrodynamic flow of laser-accelerated matter, are analyzed. Requirements to the igniting-driver parameters that depend on the fast ignition criteria under the conditions of specific target heating mechanisms, as well as possibilities of practical implementation of these requirements, are discussed. The experimental programs of various laboratories and the prospects of practical implementation of fast ignition of ICF targets are reviewed. To date, fast ignition is the most promising method for decreasing the ignition energy and increasing the thermonuclear gain of an ICF plasma. A large number of publications have been devoted to investigations of this method and adjacent problems of the physics of igniting drivers and their interaction with plasma. This review presents results of only some of these studies that, in the author's opinion, allow one to discuss in detail the main physical aspects of the fast ignition concept and understand the current state and prospects of studies in this direction.

  14. Low Timing Jitter Detector for Gigahertz Quantum Key Distribution

    E-Print Network [OSTI]

    R. J. Collins; R. H. Hadfield; V. Fernandez; S. W. Nam; G. S. Buller

    2007-02-23

    A superconducting single-photon detector based on a niobium nitride nanowire is demonstrated in an optical-fibre-based quantum key distribution test bed operating at a clock rate of 3.3 GHz and a transmission wavelength of 850 nm. The low jitter of the detector leads to significant reduction in the estimated quantum bit error rate and a resultant improvement in the secrecy efficiency compared to previous estimates made by use of silicon single-photon avalanche detectors.

  15. 1. Aim of the Code of Practice 2. Key points

    E-Print Network [OSTI]

    Roelleke, Thomas

    family leave provisions 1August 2011 #12;1 Aim of the Code of Practice The aim is to: 1 promote good1. Aim of the Code of Practice 2. Key points 3. Maternity leave and pay 4. Ante-natal leave 5. Compassionate leave for family and other reasons 1 1 3 4 5 7 8 9 10 HR Code of Practice 14. Maternity and other

  16. Key Renewable Energy Opportunities for Oklahoma Tribes | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURING OFFICE INDUSTRIALU.S. DepartmentJeanKey Meeting Takeaways from 2014 Meeting

  17. Key Activities in Energy Efficiency | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested Parties - WAPA Public CommentInverted253.16582104) Kenmore: ENERGYKevinKey

  18. Key Concepts in Project Development and Financing in Alaska

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested Parties - WAPA Public CommentInverted253.16582104) Kenmore:Key2: Project

  19. Vehicle Technologies Office: Key Activities in Vehicles | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsofProgram: Report1538-1950 TimelineUtility-ScaleTechnology|Energy Key

  20. A correct security evaluation of quantum key distribution

    E-Print Network [OSTI]

    Osamu Hirota

    2014-09-21

    There is no doubt that quantum key distribution is an excellent result as a science. However, this paper presents a view on quantum key distribution (QKD) wherein QKD may have a difficulty to provide a sufficient security and good communication performance in real world networks. In fact, a one-time pad forwarded by QKD model with $\\bar{\\epsilon}=10^{-6}$ may be easily decrypted by key estimation. Despite that researchers know several criticisms on the theoretical incompleteness on the security evaluation, Portmann and Rennner, and others still avert from the discussion on criticism, and experimental groups tend to make exaggerated claims about their own work by making it seems that QKD is applicable to commercial communication systems. All such claims are based on a misunderstanding of the meaning of criteria of information theoretic security in cryptography. A severe situation has arisen as a result, one that will impair a healthy development of quantum information science (QIS). Thus, the author hopes that this paper will help to stimulate discussions on developing a more detailed theory.