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Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

A Key Target for Diabetes Drugs | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Molten Metal Solidifies into a New Kind of Glass Molten Metal Solidifies into a New Kind of Glass Organic Polymers Show Sunny Potential A New Family of Quasicrystals Cool Muscles: Storing Elastic Energy for Flight A Further Understanding of Superconductivity Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor, which could help scientists design new drugs for type 2 diabetes. (Image courtesy of Katya Kadyshevskaya, The Scripps Research Institute) The three-dimensional (3-D) atomic structure of the human glucagon receptor has been identified by an international team of researchers carrying out

2

Liposomes in Drug Targeting  

Science Journals Connector (OSTI)

Transport of drugs to target tissues, cells or subcellular organelles by the use of carrier systems is now a recognized useful method of improving drug selectivity. The types of carrier that have been proposed...

G. Gregoriadis

1980-01-01T23:59:59.000Z

3

Key Agency Targets Summary _FY 2012_.doc  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

following targets for the 12 months ending in June 2012: 1. The CGS overall performance index indicator is greater than or equal to 77.5 points (aggregate result for CGS...

4

Key Elements of and Materials Performance Targets for Highly Insulating  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Key Elements of and Materials Performance Targets for Highly Insulating Key Elements of and Materials Performance Targets for Highly Insulating Window Frames Title Key Elements of and Materials Performance Targets for Highly Insulating Window Frames Publication Type Journal Article LBNL Report Number LBNL-5099E Year of Publication 2011 Authors Gustavsen, Arlid, Steinar Grynning, Dariush K. Arasteh, Bjørn Petter Jelle, and Howdy Goudey Journal Energy and Buildings Volume 43 Issue 10 Pagination 2583-2594 Date Published 10/2011 Keywords Fenestration, heat transfer modeling, thermal performance, thermal transmittance, u-factor, window frames Abstract The thermal performance of windows is important for energy efficient buildings. Windows typically account for about 30-50 percent of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U-factor of their opaque counterparts (wall, roof and floor constructions). In well insulated buildings the U-factor of walls, roofs an floors can be between 0.1-0.2 W/(m2K). The best windows have U-values of about 0.7-1.0. It is therefore obvious that the U-factor of windows needs to be reduced, even though looking at the whole energy balance for windows (i.e. solar gains minus transmission losses) makes the picture more complex.

5

Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System  

E-Print Network [OSTI]

Hydrophobic drug paclitaxel nanoparticles (PAX NPs) and pH sensitive hydrogels were prepared in this study to build a colon targeting nanoparticle based drug delivery system for oral administration. Negative charged PAX NPs at the size of 110...

Yu, Xiao

2012-07-16T23:59:59.000Z

6

Drugs: A tangled web of targets  

Science Journals Connector (OSTI)

... was a good year. The US Food and Drug Administration (FDA) had just approved memantine, the first in a class of drugs that reduces abnormal brain activity. Scientists had ... based on each, and the field seemed to be moving in the right direction. Memantine is one of several drugs on the market in Europe and the United States that ...

Lauren Gravitz

2011-07-13T23:59:59.000Z

7

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

8

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

9

Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer  

Science Journals Connector (OSTI)

...Molecular Targets, and Chemical Biology Nanoparticle Targeting of Anticancer Drug Improves...14263. Prior studies suggested that nanoparticle drug delivery might improve the therapeutic...responses not possible with a free drug. Nanoparticle|drug delivery|PAMAM dendrimer...

Jolanta F. Kukowska-Latallo; Kimberly A. Candido; Zhengyi Cao; Shraddha S. Nigavekar; Istvan J. Majoros; Thommey P. Thomas; Lajos P. Balogh; Mohamed K. Khan; James R. Baker, Jr.

2005-06-15T23:59:59.000Z

10

Synthetic LDL as targeted drug delivery vehicle  

DOE Patents [OSTI]

The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

2012-08-28T23:59:59.000Z

11

Target Selection for the LBTI Exozodi Key Science Program  

E-Print Network [OSTI]

The Hunt for Observable Signatures of Terrestrial planetary Systems (HOSTS) on the Large Binocular Telescope Interferometer will survey nearby stars for faint emission arising from ~300 K dust (exozodiacal dust), and aims to determine the exozodiacal dust luminosity function. HOSTS results will enable planning for future space telescopes aimed at direct spectroscopy of habitable zone terrestrial planets, as well as greater understanding of the evolution of exozodiacal disks and planetary systems. We lay out here the considerations that lead to the final HOSTS target list. Our target selection strategy maximizes the ability of the survey to constrain the exozodi luminosity function by selecting a combination of stars selected for suitability as targets of future missions and as sensitive exozodi probes. With a survey of approximately 50 stars, we show that HOSTS can enable an understanding of the statistical distribution of warm dust around various types of stars and is robust to the effects of varying levels ...

Weinberger, Alycia J; Kennedy, Grant M; Roberge, Aki; Defrère, Denis; Hinz, Philip M; Millan-Gabet, Rafael; Rieke, George; Bailey, Vanessa P; Danchi, William C; Haniff, Chris; Mennesson, Bertrand; Serabyn, Eugene; Skemer, Andrew J; Stapelfeldt, Karl R; Wyatt, Mark C

2015-01-01T23:59:59.000Z

12

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network [OSTI]

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

13

Computational analysis of biochemical networks for drug target identification and therapeutic intervention design  

E-Print Network [OSTI]

Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear ...

Paudel, Nirmala

2014-01-01T23:59:59.000Z

14

Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.  

E-Print Network [OSTI]

?? The purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents,… (more)

Tsao, Ning

2013-01-01T23:59:59.000Z

15

Identification of chemogenomic features from drug–target interaction networks using interpretable classifiers  

Science Journals Connector (OSTI)

......Supplementary Information: Datasets and all results are available...protein-coupled receptors (GPCRs) or nuclear receptors. The dataset consists of 4809 drug-target...2008). Target proteins in our dataset were associated with 876 PFAM......

Yasuo Tabei; Edouard Pauwels; Véronique Stoven; Kazuhiro Takemoto; Yoshihiro Yamanishi

2012-09-15T23:59:59.000Z

16

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs  

E-Print Network [OSTI]

theranostics Guizhi Zhua,b,c , Jing Zhenga,b , Erqun Songb,d , Michael Donovana , Kejing Zhangb , Chen LiueNTrs a promising targeted drug transport platform for cancer theranostics. self-assembly | DNA nanomedicines). A theranostic (4) platform with targeted and efficient drug transport would solve these problems, and, by its

Tan, Weihong

17

Structure-based drug mechanism study and inhibitor design targeting tuberculosis  

E-Print Network [OSTI]

, ethionamide and prothionamide all target InhA, which validates the enzyme as a superb drug target. A structure-based approach was adopted to design new inhibitors targeting InhA, using triclosan as the scaffold. Guided by the InhA-inhibitor complex structures...

Wang, Feng

2009-05-15T23:59:59.000Z

18

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics  

Science Journals Connector (OSTI)

...transport of molecular drugs in cancer theranostics 10.1073/pnas.1220817110 Guizhi...drug transport platform for cancer theranostics. Although chemotherapeutic drugs are widely used in...promising TDT platform for targeted cancer theranostics. Results and Discussion Construction...

Guizhi Zhu; Jing Zheng; Erqun Song; Michael Donovan; Kejing Zhang; Chen Liu; Weihong Tan

2013-01-01T23:59:59.000Z

19

Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery  

E-Print Network [OSTI]

The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

Tan, Mei Chee

20

Multiple chemical scaffolds inhibit a promising Leishmania drug target  

Science Journals Connector (OSTI)

The need for an effective oral therapy for leishmaniasis is addressed through the study of the target N-myristoyltransferase from Leishmania major.

Walkinshaw, M.

2014-06-24T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

The licensing of patents in return for a fee or royalties has a key role in drug discovery.  

E-Print Network [OSTI]

The licensing of patents in return for a fee or royalties has a key role in drug discovery. Now the licensee brings out a new product, it may be unclear whether they need to pay royalty fees to the patentee patents in exchange for royalty payments; however, they disputed whether the licence of two patents

Cai, Long

22

International Experience with Key Program Elements of IndustrialEnergy Efficiency or Greenhouse Gas Emissions Reduction Target-SettingPrograms  

SciTech Connect (OSTI)

Target-setting agreements, also known as voluntary ornegotiated agreements, have been used by a number of governments as amechanism for promoting energy efficiency within the industrial sector. Arecent survey of such target-setting agreement programs identified 23energy efficiency or GHG emissions reduction voluntary agreement programsin 18 countries. International best practice related to target-settingagreement programs calls for establishment of a coordinated set ofpolicies that provide strong economic incentives as well as technical andfinancial support to participating industries. The key program elementsof a target-setting program are the target-setting process,identification of energy-saving technologies and measures usingenergy-energy efficiency guidebooks and benchmarking as well as byconducting energy-efficiency audits, development of an energy-savingsaction plan, development and implementation of energy managementprotocols, development of incentives and supporting policies, monitoringprogress toward targets, and program evaluation. This report firstprovides a description of three key target-setting agreement programs andthen describes international experience with the key program elementsthat comprise such programs using information from the three keytarget-setting programs as well as from other international programsrelated to industrial energy efficiency or GHG emissionsreductions.

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-02-02T23:59:59.000Z

23

Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes  

E-Print Network [OSTI]

Theranostics 2011, 1 http://www.thno.org 277 Theranostics 2011; 1:277-289 Research Paper Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes Prakash Manikwar1, Bimo A. Tejo1,2, Heather Shinogle3, David S... via a unique pathway Theranostics 2011, 1 http://www.thno.org 278 referred to as CAM-mediated endocytosis [10-13]. Ligands that bind to CAM can be used to selectively target drugs for intracellular delivery to immune cells expressing...

Manikwar, Prakash; Tejo, Bimo A.; Shinogle, Heather; Moore, David S.; Zimmerman, Tahl; Blanco, Francisco; Siahaan, Teruna J.

2010-05-10T23:59:59.000Z

24

1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds  

E-Print Network [OSTI]

proteins including enzymes, ion channels, GPCRs and nuclear receptors. However, current drug and nuclear receptors [5]. Publicly available databases have been built and maintained, such as KEGG BRITE [6 using chemical and interaction information about known compounds in the dataset. The WNN method can

Marchiori, Elena

25

Chapter 4 - Regulators of G Protein Signaling Proteins as Targets for Drug Discovery  

Science Journals Connector (OSTI)

Signaling via G-protein-coupled receptors (GPCRs) is central for the function of biological systems. Many clinically used drugs target \\{GPCRs\\} directly or target molecules involved in GPCR signaling. As an alternative to targeting receptors directly, one could modulate signaling cascades downstream of receptor activation. In recent years, there has been substantial interest in a family of proteins called regulators of G protein signaling (RGS) proteins. They modulate GPCR signaling by accelerating GTP hydrolysis on active G? subunits, thereby reducing the amplitude and duration of signaling. Modulating RGS activity would be a useful strategy to control GPCR signaling. An RGS inhibitor would be expected to enhance GPCR signaling and could do so in a tissue- or pathway-specific manner. Apart from the central GAP (GTPase accelerating protein) activity, many RGS proteins also have other functions like regulating protein–protein interactions, subcellular localization of signaling molecules, and protein translation. It is clear that these proteins serve important functions in a number of physiological and pathophysiological processes, and they are emerging as potential drug targets. This chapter gives an overview of what is currently known about biological functions of RGS proteins based on in vivo and in vitro data. We also summarize the current status in targeting RGS proteins in drug discovery.

Benita Sjögren; Levi L. Blazer; Richard R. Neubig

2010-01-01T23:59:59.000Z

26

10 - Regulator of G Protein Signaling Proteins as Drug Targets: Current State and Future Possibilities  

Science Journals Connector (OSTI)

Abstract Regulators of G protein signaling (RGS) proteins have emerged in the past two decades as novel drug targets in many areas of research. Their importance in regulating signaling via G protein-coupled receptors has become evident as numerous studies have been published on the structure and function of RGS proteins. A number of genetic models have also been developed, demonstrating the potential clinical importance of RGS proteins in various disease states, including central nervous system disorders, cardiovascular disease, diabetes, and several types of cancer. Apart from their classical mechanism of action as GTPase-activating proteins (GAPs), RGS proteins can also serve other noncanonical functions. This opens up a new approach to targeting RGS proteins in drug discovery as the view on the function of these proteins is constantly evolving. This chapter summarizes the latest development in RGS protein drug discovery with special emphasis on noncanonical functions and regulatory mechanisms of RGS protein expression. As more reports are being published on this group of proteins, it is becoming clear that modulation of GAP activity might not be the only way to therapeutically target RGS proteins.

Benita Sjögren

2011-01-01T23:59:59.000Z

27

Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)  

ScienceCinema (OSTI)

Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

Forte, Trudy

2011-04-28T23:59:59.000Z

28

Temporary blood?brain barrier disruption via focused ultrasound for targeted drug delivery in the brain  

Science Journals Connector (OSTI)

The ability to deliver drugs to the central nervous system is severely limited by the presence of the blood?brain barrier (BBB). This barrier normally serves to protect the brain and restricts the passage of most molecules from being delivered to the brain tissue from the blood stream. We have developed a method by which the BBB is temporarily disrupted in localized regions using low?power ultrasound pulses combined with a circulating ultrasound contrast agent. By systematically focusing at multiple overlapping locations one could prescribe the region in which the BBB is disrupted to conform to a desired target volume reducing drug penetration to the rest of the brain.Ultrasound parameters suited for this procedure are compatible with a device that can focus through the intact skull. In this presentation we will describe recent research on this technique discussing methodology safety possible mechanisms and potential means to guide and monitor the procedure.

Nathan McDannold

2007-01-01T23:59:59.000Z

29

Synthetic Nano-Low Density Lipoprotein as Targeted Drug DeliveryVehicle for Glioblastoma Multiforme  

SciTech Connect (OSTI)

This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDLuptake by GBM cells was LDL receptor specific and dependent on cellreceptor number. It is suggested that these synthetic particles can serveas a delivery vehicle for hydophobic anti-tumor drugs by targeting theLDL receptor.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu,Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-06-14T23:59:59.000Z

30

Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale  

Science Journals Connector (OSTI)

...tumors. Fourth, the results highlight the increasing use/abuse of stable disease as a measure of drug efficacy. As discussed...1995;332:1004-14. 25. Drugs.com [homepage on the Internet].Paclitaxel. Available from: http://www.drugs...

Edina Komlodi-Pasztor; Dan L. Sackett; and Antonio Tito Fojo

2012-01-01T23:59:59.000Z

31

High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics  

SciTech Connect (OSTI)

Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

2014-01-01T23:59:59.000Z

32

A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products  

Science Journals Connector (OSTI)

Gillman, P. K. ( 2007) Tricyclic antidepressant pharmacology and therapeutic drug interactions updated Br. ... Gillman, P. K. ...

Anne Mai Wassermann; Eugen Lounkine; Laszlo Urban; Steven Whitebread; Shanni Chen; Kevin Hughes; Hongqiu Guo; Elena Kutlina; Alexander Fekete; Martin Klumpp; Meir Glick

2014-05-06T23:59:59.000Z

33

E-Print Network 3.0 - antibiotic drug targets Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

aureus1 Summary: or lack the target of the antibiotic. b | Multidrug resistance efflux pumps. These pumps secrete... modify the target protein, for example by disabling the...

34

E-Print Network 3.0 - anticancer drug targets Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Toronto Collection: Biology and Medicine 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

35

Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework  

Science Journals Connector (OSTI)

......channels, GPCRs and nuclear receptors. Our comprehensively...Supplementary information: Datasets and all prediction results...receptors (GPCRs) and nuclear receptors. Owing to...channels, GPCRs and nuclear receptors. Our comprehensively...genomic drug discovery. Datasets and all prediction results......

Yoshihiro Yamanishi; Masaaki Kotera; Minoru Kanehisa; Susumu Goto

2010-06-15T23:59:59.000Z

36

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

37

Identification of novel synergistic targets RACK-1 and galectin-1 for rational drug combinations with PI3 Kinase inhibitors using siRNA synthetic lethality screening.  

Science Journals Connector (OSTI)

...Proffered Abstracts AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA Identification of novel synergistic targets RACK-1 and galectin-1 for rational drug combinations with PI3 Kinase inhibitors using siRNA synthetic lethality screening. Yong...

Yong- Kim; Ningyi Tiao; Tiffany Lafortune; Ta Jen Liu; Garth Powis; Alfred WK Yung; Dimpy Koul

2008-05-01T23:59:59.000Z

38

IN VITRO AND IN VIVO EVALUATION OF NOVEL I-DOMAIN CONJUGATES FOR DRUG TARGETING TO IMMUNE CELLS AND SUPPRESSION OF EAE IN MICE  

E-Print Network [OSTI]

The long-term objective of this project is to utilize the I-domain of leukocyte function associated antigen-1 (LFA-1) to target antigenic peptides and drugs to intercellular adhesion molecule-1 (ICAM-1) expressed on the ...

Manikwar, Prakash

2010-06-23T23:59:59.000Z

39

Drug–target interaction prediction through domain-tuned network-based inference  

Science Journals Connector (OSTI)

......measure of sparsity Dataset Structures Targets...95 635 0.0299 Nuclear receptors 54 26...channels, GPCRs, and nuclear receptor datasets using the top-30...built on the four datasets (enzymes, ion channels, GPCRs and nuclear receptors) Table......

Salvatore Alaimo; Alfredo Pulvirenti; Rosalba Giugno; Alfredo Ferro

2013-08-15T23:59:59.000Z

40

Predicting drug–target interactions from chemical and genomic kernels using Bayesian matrix factorization  

Science Journals Connector (OSTI)

......provide visualizations on Nuclear Receptor dataset due to its small network...proteins obtained by KBMF2K on Nuclear Receptor dataset with (A) held-out drug...dimensionality and nu = 0. On Nuclear Receptor dataset, we do not see any effect......

Mehmet Gönen

2012-09-15T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Perspective on the Pipeline of Drugs Being Developed with Modulation of DNA Damage as a Target  

Science Journals Connector (OSTI)

...When considering the pipeline of novel agents that...which blocking a DNA repair pathway was the primary...RD D'Andrea AD. DNA repair pathways in clinical...Perspective on the pipeline of drugs being developed...various elements of the DNA repair pathways have entered...

Ruth Plummer

2010-09-15T23:59:59.000Z

42

New Computational Approaches for NMR-based Drug Design: A Protocol for Ligand Docking to Flexible Target Sites  

SciTech Connect (OSTI)

NMR-based drug design has met with some success in the last decade, as illustrated in numerous instances by Fesik's ''ligand screening by NMR'' approach. Ongoing efforts to generalize this success have led us to the development of a new paradigm in which quantitative computational approaches are being integrated with NMR derived data and biological assays. The key component of this work is the inclusion of the intrinsic dynamic quality of NMR structures in theoretical models and its use in docking. A new computational protocol is introduced here, designed to dock small molecule ligands to flexible proteins derived from NMR structures. The algorithm makes use of a combination of simulated annealing monte carlo simulations (SA/MC) and a mean field potential informed by the NMR data. The new protocol is illustrated in the context of an ongoing project aimed at developing new selective inhibitors for the PCAF bromodomains that interact with HIV Tat.

Gracia, Luis; Speidel, Joshua A. [Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York NY 10028 (United States); Weinstein, Harel [Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York NY 10028 (United States); HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York NY 10028 (United States)

2006-08-24T23:59:59.000Z

43

Membrane protein kit may lead to better targeted drugs | Argonne National  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne scientists received an R&D100 Award for using Rhodobacter to develop a new system for growing membrane proteins used in drug discovery research. Image by Sheng-Wen Chui, University of Oxford. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne

44

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis  

Science Journals Connector (OSTI)

Utilizing a chemical genomics-based screening platform referred to as the Candida albicans fitness test (CaFT), we have identified novel inhibitors of Gwt1 and a second enzyme in the glycosylphosphatidylinositol (GPI) cell wall anchor pathway, Mcd4. ... The response of each heterozygote to the effects of the compound is then appraised by calculating a normalized Z score, with a positive value indicating hypersensitivity and a negative value reflecting resistance (or hyposensitivity) to the tested compound. ... MCD4 heterozygote hypersensitivity to M743 is directly demonstrated by serial dilution spot tests on drug-containing plates (Figure S2) and further corroborated by genetic knockdown of MCD4 expression using a conditional mutant under the control of a tetracycline-regulatable promoter (Figure S4). ...

Paul A. Mann; Catherine A. McLellan; Sandra Koseoglu; Qian Si; Elena Kuzmin; Amy Flattery; Guy Harris; Xinwei Sher; Nicholas Murgolo; Hao Wang; Kristine Devito; Nuria de Pedro; Olga Genilloud; Jennifer Nielsen Kahn; Bo Jiang; Michael Costanzo; Charlie Boone; Charles G. Garlisi; Susan Lindquist; Terry Roemer

2014-12-05T23:59:59.000Z

45

Abstract CN01-02: canSAR: An integrated cancer drug discovery informatics platform allowing systematic target evaluation.  

Science Journals Connector (OSTI)

...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...nanogels: a versatile platform for drug delivery to...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...

Bissan Al-Lazikani; Mishal Patel; Krishna Bulusu; and Mark Halling-Brown

2011-11-01T23:59:59.000Z

46

Antigen-specific blocking of immunological synapse formation using bifunctional peptide, Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes  

E-Print Network [OSTI]

Theranostics 2011, 1 http://www.thno.org 277 Theranostics 2011; 1:277-289 Research Paper Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes Prakash Manikwar1, Bimo A. Tejo1,2, Heather Shinogle3, David S... via a unique pathway Theranostics 2011, 1 http://www.thno.org 278 referred to as CAM-mediated endocytosis [10-13]. Ligands that bind to CAM can be used to selectively target drugs for intracellular delivery to immune cells expressing...

Manikwar, Prakash; Tejo, Bimo A.; Shinogle, Heather; Moore, David S.; Zimmerman, Tahl; Blanco, Francisco; Siahaan, Teruna J.

2011-05-01T23:59:59.000Z

47

Target  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lifetime measurements in Lifetime measurements in inverse kinematics Coulex Target e.g. C Stopper e.g. Cu Beam X X * C Si-Det. Yale Plunger 120 Te at 300 MeV Plunger foils Si-Detector Compton-suppressed Clover detectors (8) 50% Coulomb- barrier )] ( exp[ 1 ) ( 0 d d d P - - - = λ Probability of emitting gamma-ray while in-flight: From data: ) ( ) ( ) ( ) ( ) ( d I d I d P total shifted γ γ = where ) ( ) ( γ γ γ γ θ ε W E N I = Lifetime analysis For example: Valence proton symmetry Data from NNDC, WNSL ( 120 Te), NBI group ( 116 Te), Cologne ( 114 Te) B(E2)up [e 2 b 2 ] N A.A. Pasternak et al., EPJA 13, 435 (2002) O. Möller et al., PRC 71, 064324 (2005) Study deviations from (collective) expectations -> needs a fast and easy way to obtain data -> inverse RDDS well suited! Important in inverse kinematics: Deorientation F I J Large v/c => except for relativistic

48

A nano-immunoassay system for monitoring targeted drug impact on signaling pathways from small samples of primary hematopoietic malignancies  

Science Journals Connector (OSTI)

...An evaluation of the role of Mucin in nano drug delivery. Musaed Allkholief Robert...determine the role of mucin in the delivery of nano-sized drug delivery systems. Methods...An evaluation of the role of Mucin in nano drug delivery. [abstract]. In: Proceedings...

Alice Fan; Wilhelm Lachnit; Debabrita Deb-Basu; David Voehringer; Dean Felsher

2007-11-15T23:59:59.000Z

49

Crucial stages of protein folding through a solvable model: Predicting target sites  

E-Print Network [OSTI]

Crucial stages of protein folding through a solvable model: Predicting target sites for enzyme. Keywords: Protein-folding modeling; prediction of key folding sites; HIV-1 protease; drug resistance One

Cecconi, Fabio

50

Abstract 2986: Novel vascular targeting strategy using pegylated liposomal doxorubicin to increase drug accumulation to tumor site and therapeutic efficacy  

Science Journals Connector (OSTI)

...and therapeutic efficacy Kenji Yokoi Tomonori Tanei Yuki Saito Mauro Ferrari Houston Methodist Research Institute, Houston, TX...Citation Format: Kenji Yokoi, Tomonori Tanei, Yuki Saito, Mauro Ferrari. Novel vascular targeting strategy using pegylated...

Kenji Yokoi; Tomonori Tanei; Yuki Saito; Mauro Ferrari

2014-10-01T23:59:59.000Z

51

Oral Drug Absorption  

E-Print Network [OSTI]

properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

Yamashita, Shinji

2006-10-26T23:59:59.000Z

52

Key Outcomes:  

Broader source: Energy.gov (indexed) [DOE]

Key Points & Action Items Key Points & Action Items Inaugural Meeting Thursday, August 25, 2011 Renaissance Denver Hotel Denver, Colorado Participants Tracey LeBeau, Director, Pilar Thomas, Deputy Director, and Brandt Petrasek, Special Assistant, Department of Energy, Office of Indian Energy Policy and Programs; Vice Chairman Ronald Suppah and Jim Manion, Confederated Tribes of the Warm Springs Reservation of Oregon; William Micklin, Ewiiaapaayp Band of Kumeyaay Indians; Councilman Barney Enos, Jr., Jason Hauter, Gila River Indian Community; Mato Standing High, Rosebud Sioux Tribe; R. Allen Urban, Yocha Dehe Wintun Nation; Glen Andersen, Scott Hendrick, Brooke Oleen, Jacquelyn Pless, Jim Reed and Julia Verdi, National Conference of State Legislatures-staff

53

Temporal targets of drug action  

Science Journals Connector (OSTI)

...or Medicine recognized the role of the hypothalamus in orienting us in space. How does our orientation in time, in the same brain region, intersect with this system? The range of integrative signals between the master clock in the hypothalamus and peripheral...

Garret A. FitzGerald

2014-11-21T23:59:59.000Z

54

Are primary health care centres that target injecting drug users attracting and serving the clients they are designed for? A case study from Sydney, Australia  

Science Journals Connector (OSTI)

Background Low-threshold primary healthcare (PHC) centres targeting injecting drug users (IDUs) are increasingly being created to offer preventative and opportunistic services. However, no data are available on the characteristics of clients who utilise such services, or the effectiveness of these services in facilitating prevention or treatment. Method A retrospective clinical record audit examined the characteristics, service utilisation patterns and referral uptake of 384 clients presenting to a low-threshold PHC service in Sydney, Australia. Results Of the 384 clients, 85% were IDUs. Sixty-two percent reported also having access to a general medical practitioner (GP), with this group more likely to report taking benzodiazepines or other psychoactive medication. Despite this relatively high level of GP access, only 50% were fully vaccinated against hepatitis B virus (HBV). Testing for blood-borne viral and sexually transmitted infections were the most common reasons for presentation to the PHC. Most (82%) clients made at least one return visit, with an average of 3.5 presentations per client. All clients were offered HBV vaccination where indicated (n = 145); and more than half (55%) of referrals to external services were attended. Clients accessing this PHC were younger, more likely to be male and born outside Australia than \\{IDUs\\} attending needle syringe programs (NSPs) in Australia's most populous state, New South Wales. Conclusion Results suggest that this low-threshold PHC service was underutilised and its role as a low-threshold healthcare outlet remains limited. Further research is needed to more clearly delineate the health and economic benefits of this model.

M. Mofizul Islam; Libby Topp; Katherine M. Conigrave; Ann White; Paul S. Haber; Carolyn A. Day

2013-01-01T23:59:59.000Z

55

TARGETING TRICLOSAN  

Science Journals Connector (OSTI)

TARGETING TRICLOSAN ... FEDERAL REGULATORS are worried about the potential for antibiotic resistance and endocrine disruption from human exposure to triclosan, an antibacterial ingredient found in numerous consumer products, including soaps, body washes, cutting boards, and toys. ... “Existing data raise valid concerns about the effects of repetitive daily human exposure” to triclosan, the Food & Drug Administration wrote in a letter to Rep. Edward J. Markey (D-Mass.), which he released on April 8. ...

BRITT ERICKSON

2010-04-19T23:59:59.000Z

56

Laser postionization secondary neutral mass spectrometry in tissue: a powerful tool for elemental and molecular imaging in the development of targeted drugs  

Science Journals Connector (OSTI)

...32 Chandra S, Lorey DRI, Smith DR. Quantitative subcellular secondary ion mass spectrometry (SIMS) imaging of boron-10 and boron-11 isotopes in the same cell delivered by two combined BNCT drugs: in vitro studies on human glioblastoma...

Andrea Wittig; Heinrich F. Arlinghaus; Christian Kriegeskotte; Raymond L. Moss; Klaas Appelman; Kurt W. Schmid; Wolfgang A.G. Sauerwein

2008-07-01T23:59:59.000Z

57

Mechanism of Binding and Internalization of ICAM-1-derived Cyclic Peptides by LFA-1 on the Surface of T-cells: A Potential Method for Targeted Drug Delivery  

E-Print Network [OSTI]

Purpose Peptides derived from the Domain 1 of the adhesion molecule ICAM-1(1-21) are being developed as targeting ligands for LFA-1 receptors expressed on activated T-cells. This work aims to elucidate the binding and ...

Anderson, Meagan E.; Siahaan, Teruna J.

2003-10-01T23:59:59.000Z

58

Targeted Nanomedicine for Suppression of CD44 and Simultaneous Cell Death Induction in Ovarian Cancer: An Optimal Delivery of siRNA and Anticancer Drug  

Science Journals Connector (OSTI)

...San Diego, CA Imparting superior control on materials for nanomedicine: The study of degradable, targeted PRINT nanoparticles...development of an effective platform delivery system for use in nanomedicine. Our technique, called PRINT (Particle Replication In...

Vatsal Shah; Oleh Taratula; Olga B. Garbuzenko; Olena R. Taratula; Lorna Rodriguez-Rodriguez; Tamara Minko

2013-11-15T23:59:59.000Z

59

Preparation of ?-Fe2O3/SiO2-capsule composites capable of using as drug delivery and magnetic targeting system from hydrophobic iron acetylacetonate and hydrophilic SiO2-capsule  

Science Journals Connector (OSTI)

Abstract Series of nanocomposites with ?-Fe2O3 supported on SiO2-capsules were prepared by adsorption of hydrophobic iron acetylacetonate on the hydrophilic surface of SiO2-capsules in the evaporation process of the solvent and then calcination the complex at 450 °C. The adsorption and calcination conditions were studied and the resultant nanaoparticles were characterized by XRD, XRF and TEM in detail. The results indicated that ?-Fe2O3 loaded discontinuously but uniformly on the surface of SiO2-capsules at appropriate content. The specific surface area characterization and doxorubicin hydrochloride release shown although the surface area of the target composites decreased slightly, the nanoparticles still had large potential using as drug delivery and magnetic targeting system.

Fengzhu Lv; Liling Fu; Emmanuel P. Giannelis; Genggeng Qi

2014-01-01T23:59:59.000Z

60

Targeting the tumor microenvironment  

SciTech Connect (OSTI)

Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

2006-11-07T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Preventing Quantum Hacking in Continuous Variable Quantum Key Distribution  

Science Journals Connector (OSTI)

Security loopholes have been shown for discrete-variable Quantum Key Distribution (QKD). Here, we propose and provide experimental evidence of an attack targeting a continuous-variable...

Jouguet, Paul; Diamanti, Eleni; Kunz-Jacques, Sébastien

62

Public Key Cryptography and Key Management  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The use and management of certificate-based public key cryptography for the Department of Energy (DOE) requires the establishment of a public key infrastructure (PKI). This chapter defines the policy related to roles, requirements, and responsibilities for establishing and maintaining a DOE PKI and the documentation necessary to ensure that all certificates are managed in a manner that maintains the overall trust required to support a viable PKI. Canceled by DOE N 251.112.

2000-02-15T23:59:59.000Z

63

Controlling drug delivery across the placenta: A commentary  

E-Print Network [OSTI]

A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

Audus, Kenneth L.

1999-01-01T23:59:59.000Z

64

Prescription Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Prescription Drugs Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue Cross and Blue Shield of New Mexico (BCBSNM) health plan includes a prescription drug benefit administered by Prime Therapeutics. The cost of the prescription drug plan is included in your medical premiums. Coverage The co-pays for prescription drugs are based on a 3-tier prescription drug benefit. Co-payments are different for formulary or non-formulary, generic, or brand/preferred name. Review the BCBSNM Drug List (pdf) to find out which tier a specific drug falls under. Co-pays Prescription drug co-pays vary from plan to plan. 2013 EPO Summary of Benefits (pdf) 2013 PPO Summary of Benefits (pdf)

65

Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology  

Science Journals Connector (OSTI)

...Russia) and Matlab/SimBiology...or 2011b (Matlab, Natick...differential equations using the...page-meeting.org/pdf_assets...1). The simulations were consistent...involved in the processes controlling...extracellular matrix 2 Grb2...integral matrix subplot showing...Model 3 simulations with and...

2013-01-01T23:59:59.000Z

66

Locoregional Cancer Treatment with Magnetic Drug Targeting  

Science Journals Connector (OSTI)

...University of Munich, 81675 Munich; Physics-Department E 17, Technical University...the instructions of Kirk and Bistners handbook of veterinarian procedures and emergency...M. R. (eds.), Kirk and Bistners Handbook of Veterinarian Procedures and Emergency...

Christoph Alexiou; Wolfgang Arnold; Roswitha J. Klein; Fritz G. Parak; Peter Hulin; Christian Bergemann; Wolfgang Erhardt; Stefan Wagenpfeil; and Andreas S. Lübbe

2000-12-01T23:59:59.000Z

67

Targeting of drugs and nanoparticles to tumors  

E-Print Network [OSTI]

The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as ...

Ruoslahti, Erkki

68

Nanomedicine Seminar Series I Key drivers in nano-medicine  

E-Print Network [OSTI]

Nanomedicine Seminar Series ­ I Key drivers in nano-medicine Key application spaces Biosensing for superbug drug resistance Nature Nanotechnology 3 691 696 (2008) reagent storage. Lab Chip, 2008, 8, 2038 ­ 2045 Funded by Gates Foundation Nature Nanotechnology 3, 691 696 (2008) Funded by Gates Foundation 9

69

ARM - Key Science Questions  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

govScienceKey Science Questions govScienceKey Science Questions Science Research Themes Research Highlights Journal Articles Collaborations Atmospheric System Research (ASR) ARM Science Team Meetings User Meetings Annual Meetings of the Atmospheric System Research (ASR) Science Team and Fall Working Groups Accomplishments Read about the 20 years of accomplishments (PDF, 696KB) from the ARM Program and user facility. Performance Metrics ASR Metrics 2009 2008 2007 2006 Key Science Questions The role of clouds and water vapor in climate change is not well understood; yet water vapor is the largest greenhouse gas and directly affects cloud cover and the propagation of radiant energy. In fact, there may be positive feedback between water vapor and other greenhouse gases. Carbon dioxide and other gases from human activities slightly warm the

70

Cryptographic Key Management System  

SciTech Connect (OSTI)

This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene#12;ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

No, author

2014-02-21T23:59:59.000Z

71

Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery  

Science Journals Connector (OSTI)

Abstract Considerable effort has been directed towards developing novel drug delivery systems. Microfluidics, capable of generating monodisperse single and multiple emulsion droplets, executing precise control and operations on these droplets, is a powerful tool for fabricating complex systems (microparticles, microcapsules, microgels) with uniform size, narrow size distribution and desired properties, which have great potential in drug delivery applications. This review presents an overview of the state-of-the-art multiphase flow microfluidics for the production of single emulsions or multiple emulsions for drug delivery. The review starts with a brief introduction of the approaches for making single and multiple emulsions, followed by presentation of some potential drug delivery systems (microparticles, microcapsules and microgels) fabricated in microfluidic devices using single or multiple emulsions as templates. The design principles, manufacturing processes and properties of these drug delivery systems are also discussed and compared. Furthermore, drug encapsulation and drug release (including passive and active controlled release) are provided and compared highlighting some key findings and insights. Finally, site-targeting delivery using multiphase flow microfluidics is also briefly introduced.

Chun-Xia Zhao

2013-01-01T23:59:59.000Z

72

Assessing the impact of tumor evolution on oncology drug development and commercialization  

E-Print Network [OSTI]

This thesis investigates the commercial viability of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs ...

Sterk, Joseph P. (Sterk, Joseph Phillip)

2011-01-01T23:59:59.000Z

73

AP Key Accomplishments  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Recent Key Accomplishments Recent Key Accomplishments Reduction of Carbon Dioxide Mechanistic insight into CO2 hydrogenation Rapid Transfer of Hydride Ion from a Ruthenium Complex to C1 Species in Water Reversible Hydrogen Storage using CO2 and a Proton-Switchable Iridium Catalyst in Aqueous Media Nickel(II) Macrocycles: Highly Efficient Electrocatalysts for the Selective Reduction of CO2 to CO Calculation of Thermodynamic Hydricities and the Design of Hydride Donors for CO2 Reduction Mechanisms for CO Production from CO2 Using Re(bpy)(CO)3X Catalysts Hydrogen Production Biomass-derived electrocatalytic composites for hydrogen evolution Hydrogen-Evolution Catalysts Based on NiMo Nitride Nanosheets Water Oxidation Enabling light-driven water oxidation via a low-energy RuIV=O intermediate

74

Key Assumptions Policy Issues  

E-Print Network [OSTI]

11/13/2014 1 Key Assumptions and Policy Issues RAAC Steering Committee November 17, 2014 Portland Supply Limitations 8 Withi h B l i8. Within-hour Balancing 9. Capacity and Energy Values for Wind/Solar t b it d d li d· Thermal: must be sited and licensed · Wind/solar: must be sited and licensed · EE

75

Key Activities | Department of Energy  

Energy Savers [EERE]

in several key areas to advance the development and commercialization of hydrogen and fuel cell technologies. Research, Development, and Demonstration Key areas of research,...

76

A DISTRIBUTED SHARED KEY GENERATION PROCEDURE USING FRACTIONAL KEYS  

E-Print Network [OSTI]

A DISTRIBUTED SHARED KEY GENERATION PROCEDURE USING FRACTIONAL KEYS R. Poovendran, M. S. Corson, J}@isr.umd.edu ABSTRACT W e present a new class of distributed key generation and recovery algorithms suitable for group) with a Group Con- troller (GC) which can generate and distribute the keys. However, in these approaches

Baras, John S.

77

Antiretroviral drugs  

Science Journals Connector (OSTI)

In October 2010, it will be exactly 25 years ago that the first antiretroviral drug, AZT (zidovudine, 3?-azido-2?,3?-dideoxythymidine), was described. It was the first of 25 antiretroviral drugs that in the past 25 years have been formally licensed for clinical use. These antiretroviral drugs fall into seven categories [nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), fusion inhibitors (FIs), co-receptor inhibitors (CRIs) and integrase inhibitors (INIs). The \\{INIs\\} (i.e. raltegravir) represent the most recent advance in the search for effective and selective anti-HIV agents. Combination of several anti-HIV drugs [often referred to as highly active antiretroviral therapy (HAART)] has drastically altered AIDS from an almost uniformly fatal disease to a chronic manageable one.

Erik De Clercq

2010-01-01T23:59:59.000Z

78

A new weapon against an old target  

Science Journals Connector (OSTI)

High expression of folate receptors is characteristic for the effector cell population of synovial macrophages in synovial inflammation. A new drug conjugate, EC0746, targets the folate inhibitor aminopterin t...

Christoph Fiehn

2011-08-01T23:59:59.000Z

79

Key recycling in authentication  

E-Print Network [OSTI]

In their seminal work on authentication, Wegman and Carter propose that to authenticate multiple messages, it is sufficient to reuse the same hash function as long as each tag is encrypted with a one-time pad. They argue that because the one-time pad is perfectly hiding, the hash function used remains completely unknown to the adversary. Since their proof is not composable, we revisit it using a composable security framework. It turns out that the above argument is insufficient: if the adversary learns whether a corrupted message was accepted or rejected, information about the hash function is leaked, and after a bounded finite amount of rounds it is completely known. We show however that this leak is very small: Wegman and Carter's protocol is still $\\epsilon$-secure, if $\\epsilon$-almost strongly universal$_2$ hash functions are used. This implies that the secret key corresponding to the choice of hash function can be reused in the next round of authentication without any additional error than this $\\epsilon$. We also show that if the players have a mild form of synchronization, namely that the receiver knows when a message should be received, the key can be recycled for any arbitrary task, not only new rounds of authentication.

Christopher Portmann

2012-02-06T23:59:59.000Z

80

Targeting Ras in Myeloid Leukemias  

Science Journals Connector (OSTI)

...which are activated as a downstream consequence of ligand binding to growth factor receptors...case of mutant Ras due to structural consequences of substations at codons 12, 13, and...as a therapeutic target in cancer. In truth, these drugs do not significantly inhibit...

Benjamin S. Braun and Kevin Shannon

2008-04-15T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Network predicting drug's anatomical therapeutic chemical code  

Science Journals Connector (OSTI)

......validated on four drug datasets with various target...couple receptors and nuclear receptors. We found...well-collected drug datasets, the ATC-code assignments...For example, the dataset in Yamanishi et al...receptors (GPCRs) and nuclear receptors (NRs......

Yong-Cui Wang; Shi-Long Chen; Nai-Yang Deng; Yong Wang

2013-05-15T23:59:59.000Z

82

Targeting the BCR-ABL Signaling Pathway in Therapy-Resistant Philadelphia Chromosome-Positive Leukemia  

Science Journals Connector (OSTI)

...cycle-targeted drugs currently in the pipeline for testing in early-phase...investigation (14). Such pipeline drugs are not easily accessible...degradation of this nuclear repair enzyme is a sensitive indicator...cycle-targeted drugs currently in the pipeline for testing in early-phase...

Thomas O'Hare; Michael W.N. Deininger; Christopher A. Eide; Tim Clackson; and Brian J. Druker

2011-01-15T23:59:59.000Z

83

Accelerator target  

DOE Patents [OSTI]

A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

1999-06-29T23:59:59.000Z

84

Key Activities | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Key Activities Key Activities Key Activities The Water Power Program conducts work in four key areas at the forefront of water power research. The Program is structured to help the United States meet its growing energy demands sustainably and cost-effectively by developing innovative renewable water power technologies, breaking down market barriers to deployment, building the infrastructure to test new technologies, and assessing water power resources for integration into our nation's grid. Research and Development Introduce and advance new marine and hydrokinetic technologies to provide sustainable and cost-effective renewable energy from the nation's waves, tides, currents, and ocean thermal gradients. Research and develop innovative hydropower technologies to sustainably tap our country's diverse water resources including rivers,

85

Optical measurement of drug concentrations in tissue  

SciTech Connect (OSTI)

This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The aim of this project was to develop noninvasive fiber-optic methods for measuring drug concentrations in tissue. Such a system would make possible the study of chemotherapy drug kinetics at specific, targeted locations in the body after the drug is administered. The major result of this project is the development of techniques for measuring changes in absorption of a medium with unknown scattering properties. The developed method was verified by testing on several media with scattering properties in the range typically found for tissue.

Mourant, J.R.; Bigio, I.J.; Jack, D.A.; Johnson, T.M.; Miller, H.D. [Los Alamos National Lab., NM (United States). Chemical Sciences and Technology Div.

1997-10-01T23:59:59.000Z

86

Japan Retools Drug Research  

Science Journals Connector (OSTI)

Japan Retools Drug Research ... Like Takeda’s stock price, Japan’s drug R&D engine—flagging in recent years—appears to be recovering. ...

JEAN-FRANÇOIS TREMBLAY

2013-08-05T23:59:59.000Z

87

EPAct Transportation Regulatory Activities: Key Terms  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Key Terms Key Terms to someone by E-mail Share EPAct Transportation Regulatory Activities: Key Terms on Facebook Tweet about EPAct Transportation Regulatory Activities: Key Terms on Twitter Bookmark EPAct Transportation Regulatory Activities: Key Terms on Google Bookmark EPAct Transportation Regulatory Activities: Key Terms on Delicious Rank EPAct Transportation Regulatory Activities: Key Terms on Digg Find More places to share EPAct Transportation Regulatory Activities: Key Terms on AddThis.com... Home About Covered Fleets Compliance Methods Alternative Fuel Petitions Resources Guidance Documents Statutes & Regulations Program Annual Reports Fact Sheets Newsletter Case Studies Workshops Tools Key Terms FAQs Key Terms The Energy Policy Act (EPAct) includes specific terminology related to

88

EPAct Transportation Regulatory Activities: Key Federal Statutes  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Key Key Federal Statutes to someone by E-mail Share EPAct Transportation Regulatory Activities: Key Federal Statutes on Facebook Tweet about EPAct Transportation Regulatory Activities: Key Federal Statutes on Twitter Bookmark EPAct Transportation Regulatory Activities: Key Federal Statutes on Google Bookmark EPAct Transportation Regulatory Activities: Key Federal Statutes on Delicious Rank EPAct Transportation Regulatory Activities: Key Federal Statutes on Digg Find More places to share EPAct Transportation Regulatory Activities: Key Federal Statutes on AddThis.com... Home About Contacts Covered Fleets Compliance Methods Alternative Fuel Petitions Resources Key Federal Statutes These are excerpts from federal statutes that established key Energy Policy Act (EPAct) transportation regulatory activities.

89

Drug smuggling safety tests [July 1, 2006  

E-Print Network [OSTI]

enough to be utilized as drug carriers. Suslick adds that the three tests on mammalian cells they carried evidence of nano safety Login | Register Search: Site X-Ray Page 1 of 2X-Ray - Your Guide to All the Key X About Us | Contact Us | Privacy Policy | Terms & Conditions | Advertising | RSS Interested

Suslick, Kenneth S.

90

A Key Enzyme to the Potency of an Anticancer Agent  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A Key Enzyme to the Potency of A Key Enzyme to the Potency of an Anticancer Agent A Key Enzyme to the Potency of an Anticancer Agent Print Wednesday, 28 May 2008 00:00 Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline 8.2.2, discovered and characterized the chlorinating SalL enzyme, a crucial component in sal A biosynthesis that uses a unique chlorine-activating mechanism. Chlorine-Loving Enzyme Speeds Things Up

91

Abstract 4036: Drug repurposing to treat melanoma brain metastases  

Science Journals Connector (OSTI)

...4036: Drug repurposing to treat melanoma brain metastases Terje Sundstrom 1 Jobin K...of patients with metastatic melanoma, brain metastases remain an intractable problem...target single genes or pathways critical to brain metastasis formation. In this work we...

Terje Sundstrøm; Jobin K. Varughese; Francisco Azuaje; Kjell Petersen; Clifford G. Tepper; Elizabeth Ingham; Lisa Even; Sarah Tam; Kai Ove Skaftnesmo; Morten Lund-Johansen; Rolf Bjerkvig; Katherine W. Ferrara; Frits A. Thorsen

2014-10-01T23:59:59.000Z

92

Geotechnical characterization of calcareous sediments from the Dry Tortugas Keys and Marquesas Keys CBBL SRP study sites, Lower Florida Keys  

Science Journals Connector (OSTI)

Geotechnical characteristics of carbonate sediments from two test sites (Dry Tortugas Keys and Marquesas Keys) in the Lower Florida Keys were investigated as part of the Coastal Benthic Boundary Layer Special...

G. Veyera; H. Brandes; A. Silva

2001-11-01T23:59:59.000Z

93

Light Sources Help Discover New Drug Against Melanoma | Department of  

Broader source: Energy.gov (indexed) [DOE]

Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma July 18, 2011 - 12:07pm Addthis The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. Mike Ross Science Writer at SLAC National Accelerator Laboratory What does this mean for me? A new drug designed to fight melanoma was discovered thanks to the

94

Monroe County Extension Services Key West Office  

E-Print Network [OSTI]

Energy Services: 305-295-1010 Florida Keys Electric Co-op: 305-852-2431 Monroe County Roads & Bridges-292-4501 http://monroe.ifas.ufl.edu Key Largo Office: 102050 Overseas Highway, Room 244 City and County Tree Lower Keys: 305-797-4929 Upper Keys: 305-852-7161 Contact local tree services throughout the Keys

Jawitz, James W.

95

Genomics Rises To Drug Discovery Challenge  

Science Journals Connector (OSTI)

Genomics Rises To Drug Discovery Challenge ... Functional genomics and functional proteomics provide a set of powerful tools to help identify novel cellular targets ... With pharmaceutical companies and biotechnology firms always looking for ways to discover new medicines more quickly and more efficiently, they are increasingly turning to new genomics and proteomics technologies to speed things along. ...

STU BORMAN

1999-04-19T23:59:59.000Z

96

Key-Insulated Symmetric Key Cryptography and Mitigating Attacks against Cryptographic Cloud Software  

E-Print Network [OSTI]

Key-Insulated Symmetric Key Cryptography and Mitigating Attacks against Cryptographic Cloud- sociated cryptographic keys in their entirety. In this paper, we investigate key-insulated symmetric key. To illustrate the feasibility of key-insulated symmetric key cryptography, we also report a proof

Dodis, Yevgeniy

97

Identifying novel drug indications through automated reasoning Authors and Affiliations  

E-Print Network [OSTI]

of these drugs have potential anti-cancer activities based on information on their targets and molecular discovery, text mining, automated reasoning Abstract Background With the large amount of pharmacological interaction types alone. A total of 507 drugs were found to have the potential to be used for cancer

Baral, Chitta

98

Mathematical modelling of drug transport in tumour multicell spheroids and monolayer cultures  

E-Print Network [OSTI]

an enhanced survival rate in multicell spheroids compared to monolayer cultures, consistent with experimental observations, and indicate that the key factor determining this is drug penetration. An analysis of the large penetration of effective quantities of drugs deep into the tumour, due to drug transport being mainly

99

Vehicle Technologies Office: Key Activities in Vehicles  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Key Activities in Key Activities in Vehicles to someone by E-mail Share Vehicle Technologies Office: Key Activities in Vehicles on Facebook Tweet about Vehicle Technologies Office: Key Activities in Vehicles on Twitter Bookmark Vehicle Technologies Office: Key Activities in Vehicles on Google Bookmark Vehicle Technologies Office: Key Activities in Vehicles on Delicious Rank Vehicle Technologies Office: Key Activities in Vehicles on Digg Find More places to share Vehicle Technologies Office: Key Activities in Vehicles on AddThis.com... Key Activities Mission, Vision, & Goals Plans, Implementation, & Results Organization & Contacts National Laboratories Budget Partnerships Key Activities in Vehicles We conduct work in four key areas to develop and deploy vehicle technologies that reduce the use of petroleum while maintaining or

100

Fuel Cell Technologies Office: Key Activities  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Key Activities to Key Activities to someone by E-mail Share Fuel Cell Technologies Office: Key Activities on Facebook Tweet about Fuel Cell Technologies Office: Key Activities on Twitter Bookmark Fuel Cell Technologies Office: Key Activities on Google Bookmark Fuel Cell Technologies Office: Key Activities on Delicious Rank Fuel Cell Technologies Office: Key Activities on Digg Find More places to share Fuel Cell Technologies Office: Key Activities on AddThis.com... Key Activities Plans, Implementation, & Results Accomplishments Organization Chart & Contacts Quick Links Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells Technology Validation Manufacturing Codes & Standards Education Systems Analysis Contacts Key Activities The Fuel Cell Technologies Office conducts work in several key areas to

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Public/private key certification authority and key distribution. Draft  

SciTech Connect (OSTI)

Traditional encryption, which protects messages from prying eyes, has been used for many decades. The present concepts of encryption are built from that heritage. Utilization of modern software-based encryption techniques implies much more than simply converting files to an unreadable form. Ubiquitous use of computers and advances in encryption technology coupled with the use of wide-area networking completely changed the reasons for utilizing encryption technology. The technology demands a new and extensive infrastructure to support these functions. Full understanding of these functions, their utility and value, and the need for an infrastructure, takes extensive exposure to the new paradigm. This paper addresses issues surrounding the establishment and operation of a key management system (i.e., certification authority) that is essential to the successful implementation and wide-spread use of encryption.

Long, J.P.; Christensen, M.J.; Sturtevant, A.P.; Johnston, W.E.

1995-09-25T23:59:59.000Z

102

SunShot Initiative: Key Activities  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Key Activities Key Activities Printable Version Share this resource Send a link to SunShot Initiative: Key Activities to someone by E-mail Share SunShot Initiative: Key Activities on Facebook Tweet about SunShot Initiative: Key Activities on Twitter Bookmark SunShot Initiative: Key Activities on Google Bookmark SunShot Initiative: Key Activities on Delicious Rank SunShot Initiative: Key Activities on Digg Find More places to share SunShot Initiative: Key Activities on AddThis.com... Concentrating Solar Power Photovoltaics Systems Integration Balance of Systems Key Activities Under the SunShot Initiative, the DOE Solar Office issues competitive solicitations that fund selective research projects aimed at transforming the ways the United States generates, stores, and utilizes solar energy.

103

Alternative Fuels Data Center: Key Federal Legislation  

Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

Key Federal Key Federal Legislation to someone by E-mail Share Alternative Fuels Data Center: Key Federal Legislation on Facebook Tweet about Alternative Fuels Data Center: Key Federal Legislation on Twitter Bookmark Alternative Fuels Data Center: Key Federal Legislation on Google Bookmark Alternative Fuels Data Center: Key Federal Legislation on Delicious Rank Alternative Fuels Data Center: Key Federal Legislation on Digg Find More places to share Alternative Fuels Data Center: Key Federal Legislation on AddThis.com... More in this section... Federal State Advanced Search All Laws & Incentives Sorted by Type Key Federal Legislation The information below includes a brief chronology and summaries of key federal legislation related to alternative fuels and vehicles, air quality,

104

Drug Conjugates Lure Investment  

Science Journals Connector (OSTI)

Drug Conjugates Lure Investment ... Only two antibody-drug conjugates are on the market— Roche’s Kadcyla for breast cancer and Seattle Genetics’s Adcetris for lymphoma—but developers are stepping up investment in this new drug class. ... The new plant is part of a larger investment by the company in biologics manufacturing (see page 17). ...

ANN THAYER

2013-10-21T23:59:59.000Z

105

Renewable Energy Community: Key Elements  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Energy of Energy Office of Energy Efficiency & Renewable Energy National Renewable Energy Laboratory Innovation for Our Energy Future A Renewable Energy Community: Key Elements A reinvented community to meet untapped customer needs for shelter and transportation with minimal environmental impacts, stable energy costs, and a sense of belonging N. Carlisle, J. Elling, and T. Penney Technical Report NREL/TP-540-42774 January 2008 NREL is operated by Midwest Research Institute ● Battelle Contract No. DE-AC36-99-GO10337 National Renewable Energy Laboratory 1617 Cole Boulevard, Golden, Colorado 80401-3393 303-275-3000 * www.nrel.gov Operated for the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy by Midwest Research Institute * Battelle

106

Targeted Nanogels: A Versatile Platform for Drug Delivery to Tumors  

Science Journals Connector (OSTI)

...a prime operation platform for implementation of chemical reactions (12-15...operation of complicated chemical (19, 20) and biological...in stand-alone platforms. PDMS devices are...devices coupled to chemical and physical changes...

Eric A. Murphy; Bharat K. Majeti; Rajesh Mukthavaram; Lisette M. Acevedo; Leo A. Barnes; and David A. Cheresh

2011-06-01T23:59:59.000Z

107

Gaussian interaction profile kernels for predicting drug–target interaction  

Science Journals Connector (OSTI)

......2009). For the GPCR and nuclear receptor datasets, the method with the highest...Ion Channel, GPCR and nuclear receptor datasets, respectively. These results...predictions. Finally, on the Nuclear Receptor dataset, BY09 and RLS-Kron-avg......

Twan van Laarhoven; Sander B. Nabuurs; Elena Marchiori

2011-11-01T23:59:59.000Z

108

Pharmacokinetics, or "How a drug reaches its target"  

E-Print Network [OSTI]

15 20 25 30 35 40 45 Time (days) Concentration(mg·L-1) InL Michaelis-Menten(L) Cld CP, VcCt, Vt koff ke(RL) InL L = Ligand R = receptor RL = Receptor-Ligand complex ke(L) Parameter fit for data set 2 The dynamics is given by the system of nonlinear differential equations: dL dt = InL - konL · R + koff

Gugat, Martin

109

Adenosine A2A Receptor as a Drug Discovery Target  

Science Journals Connector (OSTI)

Binodenoson development appears to have been halted after Pfizer acquired King Pharmaceuticals, since binodenoson is not listed in Pfizer’s pipeline. ... Importantly, these results demonstrate that the orally active dual adenosine A2A and A1 receptor antagonist 62 can repair motor impairments via A2A receptor antagonism. ... As a result, compound 72, which is a potent adenosine A2A receptor antagonist (hA2A Ki = 0.4 nM) with good selectivity over the human A1 receptor (100-fold), showed a clean hERG profile (patch-clamp IC50 = 1200 nM) and good aqueous solubility (0.21 mg/mL, pH 5). ...

Manuel de Lera Ruiz; Yeon-Hee Lim; Junying Zheng

2013-10-28T23:59:59.000Z

110

Polarized internal target apparatus  

DOE Patents [OSTI]

A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

Holt, R.J.

1984-10-10T23:59:59.000Z

111

Polarized internal target apparatus  

DOE Patents [OSTI]

A polarized internal target apparatus with a polarized gas target of improved polarization and density achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms.

Holt, Roy J. (Downers Grove, IL)

1986-01-01T23:59:59.000Z

112

Management strategies for endangered Florida Key deer  

E-Print Network [OSTI]

Urban development is of particular concern in the management of endangered Key deer (Odocoileous virginianus clavium) because highway mortality is the greatest single cause of deer mortality (? 50%), and the rural community of Big Pine Key, Florida...

Peterson, Markus Nils

2004-09-30T23:59:59.000Z

113

Magnetically attached sputter targets  

DOE Patents [OSTI]

An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

Makowiecki, D.M.; McKernan, M.A.

1994-02-15T23:59:59.000Z

114

T-571: Linux Kernel dns_resolver Key Processing Error Lets Local Users Deny  

Broader source: Energy.gov (indexed) [DOE]

1: Linux Kernel dns_resolver Key Processing Error Lets Local 1: Linux Kernel dns_resolver Key Processing Error Lets Local Users Deny Services T-571: Linux Kernel dns_resolver Key Processing Error Lets Local Users Deny Services March 7, 2011 - 3:05pm Addthis PROBLEM: Linux Kernel dns_resolver Key Processing Error Lets Local Users Deny Services. PLATFORM: Linux Kernel 2.6.37 and prior versions ABSTRACT: A vulnerability was reported in the Linux Kernel. A local user can cause denial of service conditions. reference LINKS: SecurityTracker Alert ID:1025162 Latest Stable Kernel CVE-2011-1076 IMPACT ASSESSMENT: High Discussion: When a DNS resolver key is instantiated with an error indication, a local user can attempt to read the key to trigger a null pointer dereference and cause a kernel crash. A local user can cause the target system to crash.

115

Government Cuts Biofuels Targets  

Science Journals Connector (OSTI)

Government Cuts Biofuels Targets ... The Environmental Protection Agency has proposed lowering next year’s production targets for biofuels in the U.S. fuel mix—targets initially set in the Energy Independence & Security Act of 2007. ... Although the petroleum industry says the new targets still call for too much ethanol, biofuels advocates say changes to the Renewable Fuel Standard could kill the fledgling advanced biofuels industry. ...

MELODY BOMGARDNER; JEFF JOHNSON

2013-11-25T23:59:59.000Z

116

Thailand-Key Results and Policy Recommendations for Future Bioenergy  

Open Energy Info (EERE)

and Policy Recommendations for Future Bioenergy and Policy Recommendations for Future Bioenergy Development Jump to: navigation, search Name Thailand-Key Results and Policy Recommendations for Future Bioenergy Development Agency/Company /Organization Food and Agriculture Organization of the United Nations Sector Land Focus Area Biomass, Agriculture Topics Co-benefits assessment, Policies/deployment programs, Background analysis Resource Type Lessons learned/best practices Website http://www.fao.org/docrep/013/ Country Thailand UN Region South-Eastern Asia References Thailand-Key Results and Policy Recommendations for Future Bioenergy Development[1] Abstract "The Government of Thailand, through its Alternative Energy Development Plan, has set a target to increase biofuel production to five billion

117

High Power Cryogenic Targets  

SciTech Connect (OSTI)

The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

Gregory Smith

2011-08-01T23:59:59.000Z

118

U-008: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote  

Broader source: Energy.gov (indexed) [DOE]

08: Symantec Data Loss Prevention Bugs in KeyView Filter Lets 08: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote Users Deny Service U-008: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote Users Deny Service October 11, 2011 - 8:00am Addthis PROBLEM: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote Users Deny Service PLATFORM: Symantec Data Loss Prevention Enforce/Detection Servers for Windows 10.x, 11.x ABSTRACT: A remote user can create a file that, when processed by the target filter, will cause partial denial of service conditions. reference LINKS: Symantec Security Advisory SYM11-013 SecurityTracker Alert ID: 1026157 IMPACT ASSESSMENT: Medium Discussion: Multiple vulnerabilities were reported in Symantec Data Loss Prevention. A remote user can cause denial of service conditions on the target system.A

119

A Key Enzyme to the Potency of an Anticancer Agent  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A Key Enzyme to the Potency of an Anticancer Agent Print A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline 8.2.2, discovered and characterized the chlorinating SalL enzyme, a crucial component in sal A biosynthesis that uses a unique chlorine-activating mechanism. Chlorine-Loving Enzyme Speeds Things Up The smell of chlorine is unmistakable. It's in the swimming pool, in household bleach, and sometimes the faint odor of chlorine rises up from your tap water. But chlorine is more than a purifier and a disinfectant. It's found almost everywhere in nature-in table salt, dissolved in the ocean, and as a key ingredient in biosynthesis, a vital part of the metabolism of all living organisms.

120

Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target  

Science Journals Connector (OSTI)

...sum of an electrostatic solvation energy plus a nonpolar solvation energy. Entropic contributions to the binding free energy were estimated by calculating the...7 at 10 mumol/L was conducted by Ambit Biosciences (San Diego, CA) against...

Ariel Fernández; Angela Sanguino; Zhenghong Peng; Alejandro Crespo; Eylem Ozturk; Xi Zhang; Shimei Wang; William Bornmann; and Gabriel Lopez-Berestein

2007-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target  

Science Journals Connector (OSTI)

...hallmarks of intrinsically disordered proteins. This combination...peptides and/or proteins do have specific features...They exist as dynamic ensembles within which atom...to recognize that disordered proteins are not incorrectly...

Ariel Fernández; Angela Sanguino; Zhenghong Peng; Alejandro Crespo; Eylem Ozturk; Xi Zhang; Shimei Wang; William Bornmann; and Gabriel Lopez-Berestein

2007-05-01T23:59:59.000Z

122

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure  

Science Journals Connector (OSTI)

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure ... The human brain is a uniquely complex organ, which has evolved a sophisticated protection system to prevent injury from external insults and toxins. ... Designing molecules that can overcome this protection system and achieve optimal concentration at the desired therapeutic target in the brain is a specific and major challenge for medicinal chemists working in CNS drug discovery. ...

Zoran Rankovic

2014-12-11T23:59:59.000Z

123

Molecular mechanism of an adverse drug–drug interaction of allopurinol and furosemide in gout treatment  

Science Journals Connector (OSTI)

Abstract Gout patients receiving a combination of allopurinol and furosemide require higher allopurinol doses to achieve the target serum urate (SU) of gout patients is based on two further complementary mechanisms, the direct inhibition of XO activity by the allopurinol metabolite oxypurinol and a down-regulation of XO protein expression. The latter is compromised by addition of furosemide and might explain why patients receiving furosemide therapy require higher allopurinol doses. miR-448 was identified as a potential drug-dependent XO regulator. Finally, down-regulation of AMPK protein expression in HRCE cells by administration of oxypurinol/furosemide reveals a possible new mechanism of renal drug-induced hyperuricemia.

Claudia Knake; Lisa Stamp; Andrew Bahn

2014-01-01T23:59:59.000Z

124

Counterfactual quantum key distribution with high efficiency  

SciTech Connect (OSTI)

In a counterfactual quantum key distribution scheme, a secret key can be generated merely by transmitting the split vacuum pulses of single particles. We improve the efficiency of the first quantum key distribution scheme based on the counterfactual phenomenon. This scheme not only achieves the same security level as the original one but also has higher efficiency. We also analyze how to achieve the optimal efficiency under various conditions.

Sun Ying [State Key Laboratory of Networking and SwitchingTechnology, Beijing University of Posts and Telecommunications, Beijing 100876 (China); Beijing Electronic Science and Technology Institute, Beijing 100070 (China); Wen Qiaoyan [State Key Laboratory of Networking and SwitchingTechnology, Beijing University of Posts and Telecommunications, Beijing 100876 (China)

2010-11-15T23:59:59.000Z

125

Targeting Illegal Immigration: Local Ordinate Action  

E-Print Network [OSTI]

is adapted, but distinct from, a report on the topic prepared for the U.S. Congressional Research Service. Local Ordinances Targeting Illegal Immigration 1 Executive Summary It has been traditionally the federal government?s responsibility...,000 municipalities and 3,000 counties in the United States, only 21 localities have passed legislation addressing unauthorized immigration in the key areas thought to influence illegal immigration?housing and employment. These ordinances were all passed between...

Gunn, Emily; Moffitt, Jessica; Montemayor, Victoria; Riedel, Sarah; Smith, Bart; Weizel, Daniel

2008-01-01T23:59:59.000Z

126

Illicit drugs in the environment  

Science Journals Connector (OSTI)

...Nick Voulvoulis Illicit drugs in the environment Ettore Zuccato Sara Castiglioni...but risks for human health and the environment cannot be excluded. Morphine, cocaine...time. illicit drugs|drugs of abuse|environment|sewage treatment plant|wastewater...

2009-01-01T23:59:59.000Z

127

Advanced Target Effects Modeling  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

modeling of NDCX-II experiments include certain lower temper- ature effects, e.g., surface tension and target fragmentation, that are not generally present in extreme...

128

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hohlraum This artist's rendering shows a NIF target pellet inside a hohlraum capsule with laser beams entering through openings on either end. The beams compress and heat the...

129

Neutron crystallography aids drug design  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Neutron crystallography aids drug design Neutron crystallography aids drug design Researchers have used neutron crystallography for the first time to determine the structure of a...

130

Monroe County Extension Services Key West Office  

E-Print Network [OSTI]

-292-4501 http://monroe.ifas.ufl.edu Key Largo Office: 102050 Overseas Highway, Room 244 City and County Tree Energy Services: 305-295-1010 Florida Keys Electric Co-op: 305-852-2431 Monroe County Roads & Bridges conditions based on USDA zone, water and light requirements, soil conditions, salt and wind tolerance

Florida, University of

131

residential sector key indicators | OpenEI  

Open Energy Info (EERE)

residential sector key indicators residential sector key indicators Dataset Summary Description This dataset is the 2009 United States Residential Sector Key Indicators and Consumption, part of the Source EIA Date Released March 01st, 2009 (5 years ago) Date Updated Unknown Keywords AEO consumption EIA energy residential sector key indicators Data application/vnd.ms-excel icon 2009 Residential Sector Key Indicators and Consumption (xls, 55.3 KiB) Quality Metrics Level of Review Peer Reviewed Comment Temporal and Spatial Coverage Frequency Annually Time Period License License Open Data Commons Public Domain Dedication and Licence (PDDL) Comment http://www.eia.gov/abouteia/copyrights_reuse.cfm Rate this dataset Usefulness of the metadata Average vote Your vote Usefulness of the dataset Average vote Your vote

132

Fuel Cell Technologies Office: Key Activities  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Key Activities Key Activities The Fuel Cell Technologies Office conducts work in several key areas to advance the development and commercialization of hydrogen and fuel cell technologies. Research, Development, and Demonstration Key areas of research, development, and demonstration (RD&D) include the following: Fuel Cell R&D, which seeks to improve the durability, reduce the cost, and improve the performance of fuel cell systems, through advances in fuel cell stack and balance of plant components Hydrogen Fuel R&D, which focuses on enabling the production of low-cost hydrogen fuel from diverse renewable pathways and addressing key challenges to hydrogen delivery and storage Manufacturing R&D, which works to develop and demonstrate advanced manufacturing technologies and processes that will reduce the cost of fuel cell systems and hydrogen technologies

133

drug safety monitoring (DSM)  

Science Journals Connector (OSTI)

Active surveillance for drug safety (in contrast to spontaneous report system); active surveillance systems usually have higher response rates than “passive” systems such as the yellow card programme; ? see also

Dr. med. Dr. phil. Gerhard Nahler

2009-01-01T23:59:59.000Z

134

Fixed target electroweak and hard scattering physics  

SciTech Connect (OSTI)

The possibilities for future physics and experiments involving weak and electromagnetic interactions, neutrino oscillations, general hard scattering and experiments involving nuclear targets were explored. The studies were limited to the physics accessible using fixed target experimentation. While some of the avenues explored turn out to be relatively unrewarding in the light of competition elsewhere in the world, there are a number of positive conclusions reached about experimentation in the energy range available to the Main Injector and Tevatron. Some of the experiments would benefit from the increased intensity available from the Tevatron utilizing the Main Injector, while some require this increase. Finally, some of the experiments would use the Main Injector low energy, high intensity extracted beams directly. A program of electroweak and hard scattering experiments at fixed target energies retains the potential for important contributions to physics. The key to major parts of this program would appear to be the existence of the Main Injector. 115 refs, 17 figs.

Brock, R. (Michigan State Univ., East Lansing, MI (USA)); Brown, C.N.; Montgomery, H.E. (Fermi National Accelerator Lab., Batavia, IL (USA)); Corcoran, M.D. (eds.) (Rice Univ., Houston, TX (USA))

1990-02-01T23:59:59.000Z

135

A systems approach to uncovering the adaptive response of cancer to targeted therapies  

E-Print Network [OSTI]

Tyrosine kinase inhibitors have significant promise in the fight to develop agents that can target cancer in a tumor-specific manner. A number of drugs have been and are currently in development to inhibit specific kinases ...

Randall, Adrian Joseph

2012-01-01T23:59:59.000Z

136

Nanoparticle-Aptamer Bioconjugates: A New Approach for Targeting Prostate Cancer Cells  

Science Journals Connector (OSTI)

Advances in Brief Nanoparticle-Aptamer BioconjugatesA New Approach...nontargeted cells. Next, we generated nanoparticle-aptamer bioconjugates with RNA...of targeted drug delivery with nanoparticle-aptamer bioconjugates. Introduction...

Omid C. Farokhzad; Sangyong Jon; Ali Khademhosseini; Thanh-Nga T. Tran; David A. LaVan; Robert Langer

2004-11-01T23:59:59.000Z

137

Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners  

E-Print Network [OSTI]

Background Protein covalent binding by reactive metabolites of drugs, chemicals and natural products can lead to acute cytotoxicity. Recent rapid progress in reactive metabolite target protein identification has shown ...

Hanzlik, Robert P.; Fang, Jianwen; Koen, Yakov M.

2009-06-12T23:59:59.000Z

138

Career Opportunities in Biotechnology and Drug Developmentand Drug Development  

E-Print Network [OSTI]

Career Opportunities in Biotechnology and Drug Developmentand Drug Development Career Opportunities.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 1 #12-inflammatories www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development

Puglisi, Joseph

139

Multiscale modeling and uncertainty quantification in nanoparticle-mediated drug/gene delivery  

Science Journals Connector (OSTI)

Nanoparticle (NP)-mediated drug/gene delivery involves phenomena at broad range spatial and temporal scales. The interplay between these phenomena makes the NP-mediated drug/gene delivery process very complex. In this paper, we have identified four key ... Keywords: Coarse-grained molecular dynamics, Drug delivery, Fluid-structure interaction, Immersed molecular electrokinetic finite element, Molecular mean-field theory, Multiscale modeling

Ying Li, Wylie Stroberg, Tae-Rin Lee, Han Sung Kim, Han Man, Dean Ho, Paolo Decuzzi, Wing Kam Liu

2014-03-01T23:59:59.000Z

140

E-Print Network 3.0 - antimalarial drugs disrupt Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Enzyme FabI Plays a Summary: I is not the target of the antimalarial activity of triclosan, an inhibitor of bac- terial FabI. Disruption of fab... antimalarial drug that...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Captured key electrical safety lockout system  

DOE Patents [OSTI]

A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member`s second position corresponds to the preselected position at which the key can be removed from and inserted into the lock. 7 figs.

Darimont, D.E.

1995-10-31T23:59:59.000Z

142

Captured key electrical safety lockout system  

SciTech Connect (OSTI)

A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member's second position corresponds to the preselected position at which the key can be removed from and inserted into the lock.

Darimont, Daniel E. (Aurora, IL)

1995-01-01T23:59:59.000Z

143

Introduction The kinase Raf is a key target of the Ras GTPase during both  

E-Print Network [OSTI]

substrates (Sontag et al., 1993; Alessi et al., 1995; Wassarman et al., 1996; Maixner et al., 1998; Ugi et al

Baillie, David

144

Key Elements of and Materials Performance Targets for Highly Insulating Window Frames  

E-Print Network [OSTI]

Norway Abstract The thermal performance of windows is important for energyNorway Norwegian University of Science and Technology Howdy Goudey Lawrence Berkeley National Laboratory Environmental Energy

Gustavsen, Arild

2012-01-01T23:59:59.000Z

145

Research Summary Key Ingredients of Collaborative Management  

E-Print Network [OSTI]

, wildlife management and water catchments. This project, developed in discussion with stakeholders, soughtResearch Summary Key Ingredients of Collaborative Management It is widely accepted that collaboration amongst stakeholders can lead to more sustainable land-management. Voluntary collaboration

146

Extracting secret keys from integrated circuits  

E-Print Network [OSTI]

Modern cryptographic protocols are based on the premise that only authorized participants can obtain secret keys and access to information systems. However, various kinds of tampering methods have been devised to extract ...

Lim, Daihyun, 1976-

2004-01-01T23:59:59.000Z

147

Composite keys? | OpenEI Community  

Open Energy Info (EERE)

Composite keys? Composite keys? Home > Groups > Databus Does DataBus support using composite keys in a Table definition? If not, is there a way to automatically generate a unique value for each entry that is uploaded? Submitted by Hopcroft on 5 September, 2013 - 17:13 1 answer Points: 0 At this time, no, and no way to generate unique key either right now. You can submit a feature request for this though on github. thanks, Dean Deanhiller on 6 September, 2013 - 06:58 Groups Menu You must login in order to post into this group. Recent content Go to My Databus->Data Streams... yes, it is done the same way y... Update rows? How to use streaming chart? if you are an administrator, s... more Group members (6) Managers: Deanhiller Recent members: Hopcroft Vikasgoyal Ksearight NickL

148

Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...review-article Minireview Energy Metabolism and Drug Efflux...of ATP. This suggests that energy metabolism and ATP production...treatment of XDR-TB patients in Argentina and is currently being used...bacterial targets involved in energy metabolism. These combinations...

Philippa A. Black; Robin M. Warren; Gail E. Louw; Paul D. van Helden; Thomas C. Victor; Bavesh D. Kana

2014-03-10T23:59:59.000Z

149

Aspects of Key Largo woodrat ecology  

E-Print Network [OSTI]

for the last 25 years. Population 6 estimates also suggest that the KLWR population is critically low and at great risk of extinction. INTRODUCTION The manatee (Trichechus manatus), Florida panther (Puma concolor coryi), and Key deer (Odocoileus...). Currently, money, management, man-power, research, and education are focused on Florida?s other more charismatic mega-fauna like the Key deer, manatee, and Florida panther. Similar efforts should be made for the KLWR to determine and eliminate the causes...

McCleery, Robert Alan; Lopez, Roel R.

2004-09-30T23:59:59.000Z

150

Multipartite secret key distillation and bound entanglement  

SciTech Connect (OSTI)

Recently it has been shown that quantum cryptography beyond pure entanglement distillation is possible and a paradigm for the associated protocols has been established. Here we systematically generalize the whole paradigm to the multipartite scenario. We provide constructions of new classes of multipartite bound entangled states, i.e., those with underlying twisted Greenberger-Horne-Zeilinger (GHZ) structure and nonzero distillable cryptographic key. We quantitatively estimate the key from below with the help of the privacy squeezing technique.

Augusiak, Remigiusz; Horodecki, Pawel [Faculty of Applied Physics and Mathematics, Gdansk University of Technology, Narutowicza 11/12, 80-952 Gdansk (Poland) and ICFO-Institute Ciencies Fotoniques, Mediterranean Technology Park, 08860 Castelldefels (Barcelona) (Spain); Faculty of Applied Physics and Mathematics, Gdansk University of Technology, Narutowicza 11/12, 80-952 Gdansk (Poland)

2009-10-15T23:59:59.000Z

151

Multipartite secret key distillation and bound entanglement  

E-Print Network [OSTI]

Recently it has been shown that quantum cryptography beyond pure entanglement distillation is possible and a paradigm for the associated protocols has been established. Here we systematically generalize the whole paradigm to the multipartite scenario. We provide constructions of new classes of multipartite bound entangled states, i.e., those with underlying twisted GHZ structure and nonzero distillable cryptographic key. We quantitatively estimate the key from below with help of the privacy squeezing technique.

Remigiusz Augusiak; Pawel Horodecki

2008-11-21T23:59:59.000Z

152

Target | Open Energy Information  

Open Energy Info (EERE)

Target Target Jump to: navigation, search Name Target Address 1000 Nicollet Mall Place Minneapolis, MN Zip 55440 Website http://www.target.com Coordinates 44.9739366°, -93.2750493° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":44.9739366,"lon":-93.2750493,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

153

Photo-Targeted Nanoparticles  

Science Journals Connector (OSTI)

Photo-Targeted Nanoparticles ... The photo-dependent inhibition could be eliminated by prior addn. of glutathione or bisulfite to the irradiated soln. ... Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos ...

Tal Dvir; Matthew R. Banghart; Brian P. Timko; Robert Langer; Daniel S. Kohane

2009-11-11T23:59:59.000Z

154

MEASUREMENT OF IMPEDANCE CHARACTERISTICS OF COMPUTER KEYBOARD KEYS1  

E-Print Network [OSTI]

of computer keyboard keys are commonly used: rubber-dome and coil-spring keys. As indicated by their names, a rubber-dome key has a rubber dome under the keycap whereas a coil-spring key has a coil spring under of keys. From a user's perspective, the rubber-dome and coil-spring keys feel different. The properties

Nagurka, Mark L.

155

Marketing of New Drugs  

Science Journals Connector (OSTI)

Marketing of New Drugs ... But there was no doubt an excess of expenditure for promotional purposes in recent years and the industry is gradually reducing this because the sales department cannot ask for the marketing of as many new products has it did in the past. ...

PAUL DE HAEN

1964-10-12T23:59:59.000Z

156

Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil  

Science Journals Connector (OSTI)

Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil ... The blood brain barrier (BBB) represents the biggest challenge for therapeutic drugs to enter the brain. ... In our study, we selected chlorambucil (CHL), an alkylating agent, as the model therapeutic agent, and used scopine as a novel brain-targeting moiety. ...

Xinyi Wang; Jianbo Li; Chaoqun Xu; Yanping Li; Tao Gong; Xun Sun; Yao Fu; Qin He; Zhirong Zhang

2014-10-28T23:59:59.000Z

157

STGWG Key Outcomes for May 3, 2010  

Broader source: Energy.gov (indexed) [DOE]

Key Outcomes-Nashville 2010 Page 1 Key Outcomes-Nashville 2010 Page 1 State and Tribal Government Working Group (STGWG) Nashville, Tennessee - May 3, 2010 KEY OUTCOMES OVERVIEW Members appreciated the participation of all DOE officials at the STGWG meeting in Nashville, and are especially appreciative of the participation of high-level DOE management, such as Sky Gallegos, Deputy Assistant Secretary of the Office of Congressional and Intergovernmental Affairs, and Frank Marcinowski, Acting Chief Technical Officer and Deputy Assistant Secretary for Technical and Regulatory Support. Such participation demonstrates a continuing commitment to improve interaction with tribes and states. STGWG looks forward to our next Intergovernmental meeting with DOE in the fall. FULL STGWG ISSUES

158

Composite keys? | OpenEI Community  

Open Energy Info (EERE)

Composite keys? Home > Groups > Databus Does DataBus support using composite keys in a Table definition? If not, is there a way to automatically generate a unique value for each entry that is uploaded? Submitted by Hopcroft on 5 September, 2013 - 17:13 1 answer Points: 0 At this time, no, and no way to generate unique key either right now. You can submit a feature request for this though on github. thanks, Dean Deanhiller on 6 September, 2013 - 06:58 Groups Menu You must login in order to post into this group. Recent content Go to My Databus->Data Streams... yes, it is done the same way y... Update rows? How to use streaming chart? if you are an administrator, s... more Group members (7) Managers: Deanhiller Recent members: Bradmin Hopcroft Vikasgoyal Ksearight

159

Mediated Semi-Quantum Key Distribution  

E-Print Network [OSTI]

In this paper, we design a new quantum key distribution protocol, allowing two limited semi-quantum or "classical" users to establish a shared secret key with the help of a fully quantum server. A semi-quantum user can only prepare and measure qubits in the computational basis and so must rely on this quantum server to produce qubits in alternative bases and also to perform alternative measurements. However, we assume that the sever is untrusted and we prove the unconditional security of our protocol even in the worst case: when this quantum server is an all-powerful adversary. We also compute a lower bound of the key rate of our protocol, in the asymptotic scenario, as a function of the observed error rate in the channel allowing us to compute the maximally tolerated error of our protocol. Our results show that a semi-quantum protocol may hold similar security to a fully quantum one.

Walter O. Krawec

2014-11-21T23:59:59.000Z

160

Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer  

Science Journals Connector (OSTI)

...Fig. 2B and C). The lowest energy complex obtained from high-resolution...e., no cells are stained dark brown; left); a few TUNEL-positive...molecular target for cancer drug discovery. Oncogene 2000;19:6613-26...target for anticancer drug discovery. Recently, we developed a...

Naijie Jing; Qiqing Zhu; Ping Yuan; Yidong Li; Li Mao; and David J. Tweardy

2006-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Robust Shot Noise Measurement for Continuous Variable Quantum Key Distribution  

E-Print Network [OSTI]

We study a practical method to monitor in real-time the behavior of a Continuous Variable Quantum Key Distribution (CVQKD) system, and especially the shot noise measurement procedure, for the presence of an eavesdropper. The amount of secret key that can be extracted from the raw statistics of a CVQKD system depends strongly on a shot noise estimate since this quantity affects in particular the computation of the excess noise (i.e. noise in excess of the shot noise) added by an eavesdropper on the quantum channel. Some powerful quantum hacking attacks rely on faking the estimated value of the shot noise to hide an intercept-and-resend eavesdropping strategy, notably by targeting the calibration of the system, the saturation of the homodyne detection device or the wavelength dependency of some optical components. We describe a new countermeasure that consists in fairly general statistical tests build on top of an existing real-time shot-noise measurement technique and show that it is able to defeat all these attacks.

Sébastien Kunz-Jacques; Paul Jouguet

2014-06-29T23:59:59.000Z

162

Key valves prioritization study. Final report  

SciTech Connect (OSTI)

Key valves, installed in nuclear power plants, are those valves in which a malfunction can result in a shut down, in a reduction in power generation level, or in the extension of planned outages. Over two thousand Licensee Event Reports (LERs) are evaluated to identify the valve failure events which affected nuclear plant availability. Other data reporting systems are used to supplement the information collected for each event. A data base is established comprising 102 key valve failure events that are identified as the principal case of lost plant availability.

Riddington, J.W.

1984-10-01T23:59:59.000Z

163

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates  

Science Journals Connector (OSTI)

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates ... In the present work we sought to gain a mechanistic understanding of the physicochemical properties that influence the transport of unbound drug across the blood-brain barrier (BBB) as well as the intra- and extracellular drug exposure in the brain. ... Interpretable molecular descriptors that significantly contribute to the three key neuropharmacokinetic properties related to BBB drug transport (Kp,uu,brain), intracellular accumulation (Kp,uu,cell) and binding and distribution in the brain (Vu,brain) for a set of 40 compounds were identified using partial least squares (PLS) analysis. ...

Irena Loryan; Vikash Sinha; Claire Mackie; Achiel van Peer; Wilhelmus H. Drinkenburg; An Vermeulen; Donald Heald; Margareta Hammarlund-Udenaes; Carola M. Wassvik

2014-12-15T23:59:59.000Z

164

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer  

E-Print Network [OSTI]

Abstract Background The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This can only be achieved if the drug used is against a specific target...

Toyokawa, Gouji; Masuda, Ken; Daigo, Yataro; Cho, Hyun-Soo; Yoshimatsu, Masanori; Takawa, Masashi; Hayami, Shinya; Maejima, Kazuhiro; Chino, Makoto; Field, Helen I; Neal, David E; Tsuchiya, Eiju; Ponder, Bruce A J; Maehara, Yoshihiko; Nakamura, Yusuke; Hamamoto, Ryuji

2011-05-28T23:59:59.000Z

165

Candidate Radiation Drugs Inch Forward  

Science Journals Connector (OSTI)

Candidate Radiation Drugs Inch Forward 10.1126/science.331.6024...radiation, workers at the damaged Fukushima nuclear plant wear protective gear...Candidate radiation drugs inch forward. | News | 0 (E)-4-carboxystyryl-4-chlorobenzylsulfone...

Yudhijit Bhattacharjee

2011-03-25T23:59:59.000Z

166

Foam encapsulated targets  

DOE Patents [OSTI]

Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

1983-01-01T23:59:59.000Z

167

CHEMICAL ABBREVIATION KEY ABBREVIATION CHEMICAL NAME HAZARDS  

E-Print Network [OSTI]

Irritant destain Methanol,acetic acid,H2O Flammable, Corrosive - acid DI H2O Deionized water DCM Nitric acid Corrosive - acid KAc Potassium acetate Irritant KCl Potassium chloride Irritant K2H PO4 Corrosive - base LiCl Lithium chloride Harmful MeOH Methanol Flammable #12;CHEMICAL ABBREVIATION KEY

Pawlowski, Wojtek

168

Rangeland ecology: Key global research issues & questions  

E-Print Network [OSTI]

1 Rangeland ecology: Key global research issues & questions Robin Reid and Maria Fernandez-Gimenez This paper discusses developments in our understanding about rangeland ecology and rangeland dynamics in the last 20 years. Before the late 1980's, the mainstream view in range ecology was that livestock

169

Targeted Advertising on the Handset: Privacy and Security Challenges  

E-Print Network [OSTI]

Targeted Advertising on the Handset: Privacy and Security Challenges Hamed Haddadi, Pan Hui, Tristan Henderson and Ian Brown Abstract Online advertising is currently a rich source of revenue for many for personalised and localised advertising. A key benefit of using mobile phones is to take advantage

Henderson, Tristan

170

Targeted radionuclide therapy  

SciTech Connect (OSTI)

Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F. [Radiology Division, City of Hope National Medical Center, Duarte, California 91010 (United States); Internal Medicine, University of California Davis Medical Center, 1508 Alhambra Boulevard, Suite 3100, Sacramento, California 95816 (United States); Department of Radiation Oncology, Wallace Tumor Institute WTI No. 117, University of Alabama at Birmingham, Birmingham, Alabama 35294 (United States)

2008-07-15T23:59:59.000Z

171

TRANSFORMED DSM TARGETS GROWTH  

Science Journals Connector (OSTI)

TRANSFORMED DSM TARGETS GROWTH ... DSM CHIEF Executive Officer Feike Sijbesma refers to Charles Darwin when talking about his company’s transformation. ... In the past 10 years, DSM has transformed itself, shifting its portfolio from petrochemicals and specialties to life sciences and materials. ...

PAIGE MARIE MORSE

2011-03-14T23:59:59.000Z

172

Drug Testing for DOE Positions | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing Matrix Secretary Bodman's Memorandum Regarding Drug Testing at DOE Fact...

173

Key Facts: Solyndra Solar | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

You are here You are here Home » Key Facts: Solyndra Solar Key Facts: Solyndra Solar On September 1, 2011, Solyndra, a solar energy start-up and recipient of an Energy Department loan guarantee, declared bankruptcy. While this event is deeply disappointing, at the time the loan guarantee was issued, Solyndra was widely seen as a promising and innovative company: Solyndra was named one of the world's "50 Most Innovative Companies" in 2010 by MIT's Technology Review and included in the Wall Street Journal's "The Next Big Thing: Top 50 Venture Backed Companies." Private investors, after conducting their own careful review of Solyndra, put $1 billion of their own private capital behind the company. Solyndra reported sales growth of 40% from 2009 to 2010, from $100

174

Chemical and Petroleum Engineering Key and Lab Space Agreement  

E-Print Network [OSTI]

Chemical and Petroleum Engineering Key and Lab Space Agreement Key Holder Information Last Name and Petroleum Engineering remain the property of the Department. I agree to pay a deposit for the keys

Calgary, University of

175

Key Physical Mechanisms in Nanostructured Solar Cells  

SciTech Connect (OSTI)

The objective of the project was to study both theoretically and experimentally the excitation, recombination and transport properties required for nanostructured solar cells to deliver energy conversion efficiencies well in excess of conventional limits. These objectives were met by concentrating on three key areas, namely, investigation of physical mechanisms present in nanostructured solar cells, characterization of loss mechanisms in nanostructured solar cells and determining the properties required of nanostructured solar cells in order to achieve high efficiency and the design implications.

Dr Stephan Bremner

2010-07-21T23:59:59.000Z

176

Vehicle Electrification is Key to Reducing Petroleum Dependency...  

Broader source: Energy.gov (indexed) [DOE]

Vehicle Electrification is Key to Reducing Petroleum Dependency and Greenhouse Gas Emission Vehicle Electrification is Key to Reducing Petroleum Dependency and Greenhouse Gas...

177

Midstream Infrastructure Improvements Key to Realizing Full Potential...  

Office of Environmental Management (EM)

Midstream Infrastructure Improvements Key to Realizing Full Potential of Domestic Natural Gas Midstream Infrastructure Improvements Key to Realizing Full Potential of Domestic...

178

Key Publications - Natural Gas Regulation | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Services Natural Gas Regulation Key Publications - Natural Gas Regulation Key Publications - Natural Gas Regulation Natural Gas Imports and Exports - Quarterly Reports July...

179

Rapid Compression Machine ? A Key Experimental Device to Effectively...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Rapid Compression Machine A Key Experimental Device to Effectively Collaborate with Basic Energy Sciences Rapid Compression Machine A Key Experimental Device to Effectively...

180

Road Blocks Yield Key Information about a Catalyst | The Ames...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Road Blocks Yield Key Information about a Catalyst Researchers systematically blocked key chemical reaction pathways to get unambiguous information about how carbon-nitrogen bonds...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Sandia National Laboratories: The Brain: Key To a Better Computer  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ClimateECResearch & CapabilitiesCapabilitiesThe Brain: Key To a Better Computer The Brain: Key To a Better Computer Sandian Selected for Outstanding Young Engineer Award Sandia...

182

Apparatus for forming targets  

DOE Patents [OSTI]

Apparatus and method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

Woerner, Robert L. (Livermore, CA)

1980-01-01T23:59:59.000Z

183

Drug Therapy: Alzheimer's Disease  

Science Journals Connector (OSTI)

...provide evidence supporting the concept that vitamin E, as well as vitamin C, has a role in delaying the onset of Alzheimer's disease.– Memantine. Memantine, an N-methyl-D-aspartate antagonist recently approved by the Food and Drug Administration (FDA) for the treatment of moderate-to-severe Alzheimer's... The prevalence of Alzheimer's disease is predicted to reach 13.2 million cases in the United States. This article considers current therapeutic approaches for Alzheimer's disease. Optimal management requires accurate diagnosis, which is increasingly based on an understanding of pathophysiology. Neuroprotective strategies, cholinesterase inhibitors, psychopharmacologic agents that may reduce behavioral disturbances, and newer agents such as memantine are discussed.

Cummings J.L.

2004-07-01T23:59:59.000Z

184

An Unusual Mechanism for the Antimicrobial Target Flavine-dependant  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

An Unusual Mechanism for the Antimicrobial An Unusual Mechanism for the Antimicrobial Target Flavine-dependant Thymidylate Synthase (FTDS) Classical thymidylate synthases, encoded by the thyA and TYMS genes, are present in most eukaryotes, including humans, and are frequently targeted by chemotherapeutic and antibiotic drugs. A recently discovered class of thymidylate synthases, the FDTSs encoded by the thyX gene has been found primarily in prokaryotes and viruses including several pathogens and biological warfare agents (see http://www.cdc.gov). Several organisms, including human pathogens, rely solely on thyX for thymidylate synthesis. FDTSs share no structure or sequence homology with classical thymidylate synthases (Fig 1), and thus present a promising new frontier for antibacterial/antiviral drug development.

185

Tips for Key Maps / Inset Maps How Do I Add a Key Maps or Inset Maps  

E-Print Network [OSTI]

Tips for Key Maps / Inset Maps How Do I Add a Key Maps or Inset Maps You need a new data frame o the properties/look of the extent rectangle Tips Index Map o Should be a simplified version of the map o Should cover at least 5X the area of the main map o Should have its own scale/coordinates/title o Main coverage

Brownstone, Rob

186

Targeting Cancer More Effectively CR@B brings together researchers from across the University and the Royal United Hospital, Bath.  

E-Print Network [OSTI]

Targeting Cancer More Effectively CR@B brings together researchers from across the University to find a cure for various types of cancer. 40 academic groups from nearly every department to bedside and back again. Drug Discovery The discovery of a new family of anti-cancer drugs called steroid

Burton, Geoffrey R.

187

Quantum hacking of a continuous-variable quantum-key-distribution system using a wavelength attack  

Science Journals Connector (OSTI)

The security proofs of continuous-variable quantum key distribution are based on the assumptions that the eavesdropper can neither act on the local oscillator nor control Bob's beam splitter. These assumptions may be invalid in practice due to potential imperfections in the implementations of such protocols. In this paper, we consider the problem of transmitting the local oscillator in a public channel and propose a wavelength attack which allows the eavesdropper to control the intensity transmission of Bob's beam splitter by switching the wavelength of the input light. Specifically we target continuous-variable quantum key distribution systems that use the heterodyne detection protocol using either direct or reverse reconciliation. Our attack is proved to be feasible and renders all of the final keys shared between the legitimate parties insecure, even if they have monitored the intensity of the local oscillator. To prevent our attack on commercial systems, a simple wavelength filter should be randomly added before performing monitoring detection.

Jing-Zheng Huang; Christian Weedbrook; Zhen-Qiang Yin; Shuang Wang; Hong-Wei Li; Wei Chen; Guang-Can Guo; Zheng-Fu Han

2013-06-24T23:59:59.000Z

188

Quantum Hacking on Continuous-Variable Quantum Key Distribution System using a Wavelength Attack  

E-Print Network [OSTI]

The security proofs of continuous-variable quantum key distribution are based on the assumptions that the eavesdropper can neither act on the local oscillator nor control Bob's beam splitter. These assumptions may be invalid in practice due to potential imperfections in the implementations of such protocols. In this paper, we consider the problem of transmitting the local oscillator in a public channel and propose a wavelength attack which can allow the eavesdropper to control the intensity transmission of Bob's beam splitter by switching the wavelength of the input light. Specifically we target continuous-variable quantum key distribution systems that use the heterodyne detection protocol using either direct or reverse reconciliation. Our attack is proved to be feasible and renders all of the final key shared between the legitimate parties insecure, even if they have monitored the intensity of the local oscillator. To prevent our attack on commercial systems, a simple wavelength filter should be added before performing the monitoring detection.

Jing-Zheng Huang; Christian Weedbrook; Zhen-Qiang Yin; Shuang Wang; Hong-Wei Li; Wei Chen; Guang-Can Guo; Zheng-Fu Han

2013-02-01T23:59:59.000Z

189

In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27  

Science Journals Connector (OSTI)

New features of an antiprotozoal DNA minor-groove binding drug, which acts as a cross-linking agent, are presented. It also fills the minor groove of DNA completely and prevents the access of proteins. These features are also expected for other minor-groove binding drugs when associated with suitable DNA targets.

Acosta-Reyes, F.J.

2014-05-24T23:59:59.000Z

190

Prototype Spallation Neutron Source Rotating Target Assembly Final Test Report  

SciTech Connect (OSTI)

A full-scale prototype of an extended vertical shaft, rotating target assembly based on a conceptual target design for a 1 to 3-MW spallation facility was built and tested. Key elements of the drive/coupling assembly implemented in the prototype include high integrity dynamic face seals, commercially available bearings, realistic manufacturing tolerances, effective monitoring and controls, and fail-safe shutdown features. A representative target disk suspended on a 3.5 meter prototypical shaft was coupled with the drive to complete the mechanical tests. Successful operation for 5400 hours confirmed the overall mechanical feasibility of the extended vertical shaft rotating target concept. The prototype system showed no indications of performance deterioration and the equipment did not require maintenance or relubrication.

McManamy, Thomas J [ORNL; Graves, Van [Oak Ridge National Laboratory (ORNL); Garmendia, Amaia Zarraoa [IDOM Bilbao; Sorda, Fernando [ESS Bilbao; Etxeita, Borja [IDOM Bilbao; Rennich, Mark J [ORNL

2011-01-01T23:59:59.000Z

191

Updated distribution and reintroduction of the Lower Keys marsh rabbit  

E-Print Network [OSTI]

, privately-owned parcels of land intersecting the area encompassed by occupied or potential Lower Keys marsh rabbit populations on Boca Chica and Saddlehill keys in 2001?2003 ................................................... 116 4....2 Undeveloped and partially-developed (parcels of land intersecting the area encompassed by occupied or potential Lower Keys marsh rabbit populations on Sugarloaf and the Saddlebunch keys in 2001...

Faulhaber, Craig Alan

2005-02-17T23:59:59.000Z

192

Bone marrow endothelium-targeted therapeutics for metastatic breast cancer  

Science Journals Connector (OSTI)

Abstract Effective treatment of cancer metastasis to the bone relies on bone marrow drug accumulation. The surface proteins in the bone marrow vascular endothelium provide docking sites for targeted drug delivery. We have developed a thioaptamer that specifically binds to E-selectin that is overexpressed in the vasculature of tumor and inflammatory tissues. In this study, we tested targeted delivery of therapeutic siRNA loaded in the E-selectin thioaptamer-conjugated multistage vector (ESTA-MSV) drug carrier to bone marrow for the treatment of breast cancer bone metastasis. We evaluated tumor type- and tumor growth stage-dependent targeting in mice bearing metastatic breast cancer in the bone, and carried out studies to identify factors that determine targeting efficiency. In a subsequent study, we delivered siRNA to knock down expression of the human STAT3 gene in murine xenograft models of human MDA-MB-231 breast tumor, and assessed therapeutic efficacy. Our studies revealed that the CD31+E-selectin+ population accounted for 20.8%, 26.4% and 29.9% of total endothelial cells respectively inside the femur of mice bearing early, middle and late stage metastatic MDA-MB-231 tumors. In comparison, the double positive cells remained at a basal level in mice with early stage MCF-7 tumors, and jumped to 23.9% and 28.2% when tumor growth progressed to middle and late stages. Accumulation of ESTA-MSV inside the bone marrow correlated with the E-selectin expression pattern. There was up to 5-fold enrichment of the targeted MSV in the bone marrow of mice bearing early or late stage MDA-MB-231 tumors and of mice with late stage, but not early stage, MCF-7 tumors. Targeted delivery of STAT3 siRNA in ESTA-MSV resulted in knockdown of STAT3 expression in 48.7% of cancer cells inside the bone marrow. Weekly systemic administration of ESTA-MSV/STAT3 siRNA significantly extended survival of mice with MDA-MB-231 bone metastasis. In conclusion, targeting the overexpressed E-selectin provides an effective approach for tissue-specific drug delivery to the bone marrow. Tumor growth in the bone can be effectively inhibited by blockage of the STAT3 signaling.

Junhua Mai; Yi Huang; Chaofeng Mu; Guodong Zhang; Rong Xu; Xiaojing Guo; Xiaojun Xia; David E. Volk; Ganesh L. Lokesh; Varatharasa Thiviyanathan; David G. Gorenstein; Xuewu Liu; Mauro Ferrari; Haifa Shen

2014-01-01T23:59:59.000Z

193

Rotating Target Development for SNS Second Target Station  

SciTech Connect (OSTI)

A rotating target for the second target station (STS) at SNS has been identified as an option along with a mercury target. Evaluation of the rotating target alternative for STS has started at 1.5 MW which is considered an upper bound for the power. Previous preconceptual design work for a 3 MW rotating target is being modified for the lower power level. Transient thermal analysis for a total loss of active water cooling has been done for a simplified 2D model of the target and shielding monolith which shows that peak temperatures are well below the level at which tungsten vaporization by steam could exceed site boundary dose limits. Design analysis and integration configuration studies have been done for the target-moderator-reflector assembly which maximizes the number of neutron beam lines and provides for replacement of the target and moderators. Target building hot cell arrangement for this option will be described. An option for operation in rough vacuum without a proton beam window using Ferro fluid seals on a vertical shaft is being developed. A full scale prototypic drive module based on the 3 MW preconceptual design has been fabricated and successfully tested with a shaft and mock up target supplied by the ESS-Bilbao team. Overall planning leading to decision between mercury and the rotating target in 2011 will be discussed

McManamy, Thomas J [ORNL; Rennich, Mark J [ORNL; Crawford, Roy K [ORNL; Geoghegan, Patrick J [ORNL; Janney, Jim G [ORNL

2010-01-01T23:59:59.000Z

194

Drug Detection Study  

Office of Scientific and Technical Information (OSTI)

ORISE-07-NSEM-0544 ORISE-07-NSEM-0544 U.S. Department of Energy Office of Health, Safety and Security Office of Security Policy Drug Retention Times Center for Human Reliability Studies Oak Ridge Institute for Science and Education Operated by Oak Ridge Associated Universities For the U.S. Department of Energy Oak Ridge Associated Universities (ORAU) is a university consortium leveraging the scientific strength of major research institutions to advance science and education by partnering with national laboratories, government agencies, and private industry. ORAU manages the Oak Ridge Institute for Science and Education for the U.S. Department of Energy. The Oak Ridge Institute for Science and Education (ORISE) is a U.S. Department of Energy institute focusing on

195

Target Diagnostics Supports NIF's Path to Ignition  

SciTech Connect (OSTI)

The physics requirements derived from the National Ignition Facility (NIF) experimental campaigns are leading to a wide variety of target diagnostics. Software development for the control and analysis of these diagnostics is included in the NIF Integrated Computer Control System, Diagnostic Control System and Data Visualization. These projects implement the configuration, controls, data analysis and visual representation of most of these diagnostics. To date, over 40 target diagnostics have been developed to support NIF experiments. In 2011 diagnostics were developed or enhanced to measure Ignition performance in a high neutron yield environment. Performance is optimized around four key variables: Adiabat (a) which is the strength and timing of four shocks delivered to the target, Velocity (V) of the imploding target, Mix (M) is the uniformity of the burn, and the Shape (S) of the imploding Deuterium Tritium (DT) hot spot. The diagnostics used to measure each of these parameters is shown in figure 1. Adiabat is measured using the Velocity Interferometer System for Any Reflector (VISAR) diagnostic consisting of three streak cameras. To provide for more accurate adiabat measurements the VISAR streak cameras were enhanced in FY11 with a ten comb fiducial signal controller to allow for post shot correction of the streak camera sweep non-linearity. Mix is measured by the Neutron Time of Flight (NTOF) and Radiochemical Analysis of Gaseous Samples (RAGS) diagnostics. To accommodate high neutron yield shots, NTOF diagnostic controls are being modified to use Mach Zehnder interferometer signals to allow the digitizers to be moved from near the target chamber to the neutron shielded diagnostic mezzanine. In December 2011 the first phase of RAGS diagnostic commissioning will be completed. This diagnostic will analyze the tracers that are added to NIF target capsules that undergo nuclear reactions during the shot. These gases are collected and purified for nuclear counting by the RAGS system. Three new instrument controllers were developed and commissioned to support this diagnostic. A residual-gas analyzer (RGA) instrument measures the gas content at various points in the system. The Digital Gamma Spectrometer instrument measures the radiological spectrum of the decaying gas isotopes. A final instrument controller was developed to interface to a PLC based Gas collection system. In order to support the implosion velocity measurements an additional Gated X-ray Detector (GXD) diagnostic was tested and commissioned. This third GXD views the target through a slit contained in its snout and allows the other GXD diagnostics to be used for measuring the shape on the same shot. In order to measure the implosion shape in a high neutron environment, Actide Readout In A Neutron Environment (ARIANE) and Neutron Imaging (NI) diagnostics were commissioned. The controls for ARIANE, a fixed port gated x-ray imager, contain a neutron shielded camera and micro channel plate pulser with its neutron sensitive electronics located in the diagnostic mezzanine. The NI diagnostic is composed of two Spectral Instruments SI-1000 cameras located 20M from the target and provides neutron images of the DT hot spot for high yield shots. The development and commissioning of these new or enhanced diagnostics in FY11 have provided meaningful insight that facilitates the optimization of the four key Ignition variables. In FY12 they will be adding three new diagnostics and enhancing four existing diagnostics in support of the continuing optimization series of campaigns.

Shelton, R

2011-12-07T23:59:59.000Z

196

Key Renewable Energy Opportunities for Oklahoma Tribes  

Broader source: Energy.gov (indexed) [DOE]

TRIBAL LEADER FORUM SERIES TRIBAL LEADER FORUM SERIES KEY RENEWABLE ENERGY OPPORTUNITIES FOR OKLAHOMA TRIBES August 13, 2012 COX CONVENTION CENTER 100 West Sheridan Avenue, Oklahoma City, OK 73102 (405) 602-8500 The fifth in a series of planned U.S. DOE Office of Indian Energy-sponsored strategic energy development & investment forums, this forum is designed to give Oklahoma tribal leaders the opportunity to receive the latest updates on DOE's energy development efforts in Indian Country. The Forum will provide a venue for tribal leaders to discuss best practices in renewable energy development, including project development and finance, issues related to Oklahoma land ownership, and energy planning and energy markets. Tribal leaders will also have the opportunity to directly converse with each other by participating in a roundtable

197

Vehicle Technologies Office: Key Activities in Vehicles  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Activities in Vehicles Activities in Vehicles We conduct work in four key areas to develop and deploy vehicle technologies that reduce the use of petroleum while maintaining or improving performance, power, and comfort. Research and development (R&D); testing and analysis; government and community stakeholder support; and education help people access and use efficient, clean vehicles that meet their transportation needs. Researcher loads a sample mount of battery cathode materials for X-ray diffraction, an analysis tool for obtaining information on the crystallographic structure and composition of materials. Research and Development of New Technologies Develop durable and affordable advanced batteries as well as other forms of energy storage. Improve the efficiency of combustion engines.

198

Low-Power Public Key Cryptography  

SciTech Connect (OSTI)

This report presents research on public key, digital signature algorithms for cryptographic authentication in low-powered, low-computation environments. We assessed algorithms for suitability based on their signature size, and computation and storage requirements. We evaluated a variety of general purpose and special purpose computing platforms to address issues such as memory, voltage requirements, and special functionality for low-powered applications. In addition, we examined custom design platforms. We found that a custom design offers the most flexibility and can be optimized for specific algorithms. Furthermore, the entire platform can exist on a single Application Specific Integrated Circuit (ASIC) or can be integrated with commercially available components to produce the desired computing platform.

BEAVER,CHERYL L.; DRAELOS,TIMOTHY J.; HAMILTON,VICTORIA A.; SCHROEPPEL,RICHARD C.; GONZALES,RITA A.; MILLER,RUSSELL D.; THOMAS,EDWARD V.

2000-11-01T23:59:59.000Z

199

Structure of the MTIP-MyoA Complex, a Key Component of the Malaria Parasite  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the MTIP-MyoA Complex, a Key the MTIP-MyoA Complex, a Key Component of the Malaria Parasite Invasion Motor Malaria is one of the most devastating parasitic diseases worldwide, amounting to 300 to 500 million cases and ~2 million deaths per year (1). Multiple species of Plasmodium infect the human host, the most important ones being P. falciparum and P. vivax. Increased occurrence of multi-drug resistant Plasmodium strains reflects the need for new effective antimalarials. Human infection starts when Anopheline mosquitoes inject sporozoites into the skin during a blood meal. The sporozoites gain access to the blood stream and invade liver cells where they develop and multiply. Upon rupture of the infected liver cell, merozoites are released and rapidly enter red blood cells, where they undergo schizogony (cell multiplication) and propagate the blood cycle of the infection that causes the malaria symptoms (2).

200

Key parameters influencing the performance of photocatalytic oxidation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Key parameters influencing the performance of photocatalytic oxidation Key parameters influencing the performance of photocatalytic oxidation (PCO) air purification under realistic indoor conditions Title Key parameters influencing the performance of photocatalytic oxidation (PCO) air purification under realistic indoor conditions Publication Type Journal Article Year of Publication 2012 Authors Destaillats, Hugo, Mohamad Sleiman, Douglas P. Sullivan, Catherine Jacquiod, Jean Sablayrolles, and Laurent Molins Journal Applied Catalysis B: Environmental Volume 128 Pagination 159-170 Date Published 11/30/2012 Abstract Photocatalytic oxidation (PCO) air cleaning is a promising technology suitable for the elimination of a broad range of volatile organic compounds (VOCs). However, performance of poorly designed PCO systems may be affected by the formation of volatile aldehydes and other partially oxidized byproducts. This study explored the role of key design and dimensioning parameters that influence the effective removal of primary pollutants and can help reduce or eliminate the formation of secondary byproducts. A model pollutant mixture containing benzene, toluene, o-xylene, undecane, 1-butanol, formaldehyde and acetaldehyde was introduced at a constant rate in a 20-m3 environmental chamber operating at an air exchange rate of 1 h-1. Individual pollutant concentrations were kept at realistically low levels, between 2 and 40 μg m-3. A prototype air cleaner provided with flat or pleated PCO filtering media was operated in an external ductwork loop that recirculated chamber air at flow rates in the range 178-878 m3 h-1, corresponding to recycle ratios between 8.5 and 38. Air samples were collected upstream and downstream of the air cleaner and analyzed off-line to determine single-pass removal efficiency. The final-to-initial chamber concentration ratio was used to determine the global chamber removal efficiency for each pollutant. In the flat filter configuration, longer dwelling times of compounds on the TiO2 surface were attained by reducing the recirculation airflow by a factor of ∼5, leading to increasing total pollutant removal efficiency from 5% to 44%. Net acetaldehyde and formaldehyde removal was achieved, the later at airflow rates below 300 m3 h-1, illustrating the critical importance of controlling the contact time of primary and secondary pollutants with the TiO2 surface. The use of pleated media was shown to increase significantly the system performance by extending the dwelling time of pollutants on the irradiated surface of the PCO media, with a 70% degradation of target pollutants. With the pleated media, formaldehyde removal efficiency increased to 60%. Irradiation using either a UVC or a UVA lamp under identical flow conditions produced similar pollutant elimination. A simple correlation between the steady-state single pass removal efficiency and the global chamber removal efficiency was used to rationalize these experimental results and identify optimal operating conditions.

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Clinton plan to speed cancer drug approval  

Science Journals Connector (OSTI)

Clinton plan to speed cancer drug approval ... Accelerated approval and three other proposals "will affect at least 100 drugs now being studied," he notes, cutting FDA review time for some of these drugs from 12 months to six months. ...

1996-04-08T23:59:59.000Z

202

Report on AOAC, Narcotic and Dangerous Drugs  

Science Journals Connector (OSTI)

......Report on AOAC, narcotic and dangerous drugs. | Journal Article...Report on AOAC, Narcotic and Dangerous Drugs by Anthony Romano...Bureau of Narcotics and Dangerous Drugs, Miami, Florida 33132...substances affect- ing public health." The AOAC itself maintains......

Anthony Romano; Jr.

1972-05-01T23:59:59.000Z

203

Clinical Manifestations of Allergic Diseases: Drug Hypersensitivity  

Science Journals Connector (OSTI)

Drug allergies are those adverse drug reactions that are mediated by the specific immune system. Primary sensitization may involve T-cells alone or both T and B-cells with consecutive production of drug specif...

Benno Schnyder; Werner J. Pichler

2009-01-01T23:59:59.000Z

204

Safeguarding Quantum Key Distribution through Detection Randomization  

E-Print Network [OSTI]

We propose and experimentally demonstrate a scheme to render the detection apparatus of a Quantum Key Distribution system immune to the main classes of hacking attacks in which the eavesdropper explores the back-door opened by the single-photon detectors. The countermeasure is based on the creation of modes that are not deterministically accessible to the eavesdropper. We experimentally show that the use of beamsplitters and extra single-photon detectors at the receiver station passively creates randomized spatial modes that erase any knowledge the eavesdropper might have gained when using bright-light faked states. Additionally, we experimentally show a detector-scrambling approach where the random selection of the detector used for each measurement - equivalent to an active spatial mode randomization - hashes out the side-channel open by the detection efficiency mismatch-based attacks. The proposed combined countermeasure represents a practical and readily implementable solution against the main classes of quantum hacking attacks aimed on the single-photon detector so far, without intervening on the inner working of the devices.

Thiago Ferreira da Silva; Gustavo C. do Amaral; Guilherme B. Xavier; Guilherme P. Temporão; Jean Pierre von der Weid

2014-10-02T23:59:59.000Z

205

Compression station key to Texas pipeline project  

SciTech Connect (OSTI)

This was probably the largest pipeline project in the US last year, and the largest in Texas in the last decade. The new compressor station is a key element in this project. TECO, its servicing dealer, and compression packager worked closely throughout the planning and installation stages of the project. To handle the amount of gas required, TECO selected the GEMINI F604-1 compressor, a four-throw, single-stage unit with a six-inch stroke manufactured by Weatherford Enterra Compression Co. (WECC) in Corpus Christi, TX. TECO also chose WECC to package the compressors. Responsibility for ongoing support of the units will be shared among TECO, the service dealer and the packager. TECO is sending people to be trained by WECC, and because the G3600 family of engines is still relatively new, both the Caterpillar dealer and WECC sent people for advanced training at Caterpillar facilities in Peoria, IL. As part of its service commitment to TECO, the servicing dealer drew up a detailed product support plan, encompassing these five concerns: Training, tooling; parts support; service support; and commissioning.

NONE

1996-10-01T23:59:59.000Z

206

The OLYMPUS Internal Hydrogen Target  

E-Print Network [OSTI]

An internal hydrogen target system was developed for the OLYMPUS experiment at DESY, in Hamburg, Germany. The target consisted of a long, thin-walled, tubular cell within an aluminum scattering chamber. Hydrogen entered at the center of the cell and exited through the ends, where it was removed from the beamline by a multistage pumping system. A cryogenic coldhead cooled the target cell to counteract heating from the beam and increase the density of hydrogen in the target. A fixed collimator protected the cell from synchrotron radiation and the beam halo. A series of wakefield suppressors reduced heating from beam wakefields. The target system was installed within the DORIS storage ring and was successfully operated during the course of the OLYMPUS experiment in 2012. Information on the design, fabrication, and performance of the target system is reported.

Bernauer, J C; Ciullo, G; Henderson, B S; Ihloff, E; Kelsey, J; Lenisa, P; Milner, R; Schmidt, A; Statera, M

2014-01-01T23:59:59.000Z

207

The OLYMPUS Internal Hydrogen Target  

E-Print Network [OSTI]

An internal hydrogen target system was developed for the OLYMPUS experiment at DESY, in Hamburg, Germany. The target consisted of a long, thin-walled, tubular cell within an aluminum scattering chamber. Hydrogen entered at the center of the cell and exited through the ends, where it was removed from the beamline by a multistage pumping system. A cryogenic coldhead cooled the target cell to counteract heating from the beam and increase the density of hydrogen in the target. A fixed collimator protected the cell from synchrotron radiation and the beam halo. A series of wakefield suppressors reduced heating from beam wakefields. The target system was installed within the DORIS storage ring and was successfully operated during the course of the OLYMPUS experiment in 2012. Information on the design, fabrication, and performance of the target system is reported.

J. C. Bernauer; V. Carassiti; G. Ciullo; B. S. Henderson; E. Ihloff; J. Kelsey; P. Lenisa; R. Milner; A. Schmidt; M. Statera

2014-04-02T23:59:59.000Z

208

Mind your manners: socially appropriate wireless key establishment for groups  

Science Journals Connector (OSTI)

Group communication is inherently a social activity. However, existing protocols for group key establishment often fail to consider important social dynamics. This paper examines the human requirements for wireless group key establishment. We identify ...

Cynthia Kuo; Ahren Studer; Adrian Perrig

2008-03-01T23:59:59.000Z

209

High-dimensional entanglement-based quantum key distribution  

E-Print Network [OSTI]

Conventional quantum key distribution (QKD) uses a discrete two-dimensional Hilbert space for key encoding, such as the polarization state of a single photon. In contrast, high-dimensional QKD allows encoding onto a larger ...

Zhong, Tian, Ph. D. Massachusetts Institute of Technology

2013-01-01T23:59:59.000Z

210

Hybrid Key Management for Mobile Ad Hoc Networks  

Science Journals Connector (OSTI)

Many public key infrastructure (PKI) approaches have been proposed in ... networks (MANETs). We present a new hybrid key management infrastructure, which combines the concepts of PKIs for MANET with trusted-third...

David Sanchez Sanchez; Heribert Baldus

2006-01-01T23:59:59.000Z

211

SOW and Key Performance Parameters (KPP) Handbook Final Version...  

Broader source: Energy.gov (indexed) [DOE]

SOW and Key Performance Parameters (KPP) Handbook Final Version 9-30-2014 SOW and Key Performance Parameters (KPP) Handbook Final Version 9-30-2014 This handbook provides suggested...

212

Distributed Private-Key Generators for Identity-Based Cryptography  

Science Journals Connector (OSTI)

An identity-based encryption (IBE) scheme can greatly reduce the complexity of sending encrypted messages. However, an IBE scheme necessarily requires a private-key generator (PKG), which can create private keys ...

Aniket Kate; Ian Goldberg

2010-01-01T23:59:59.000Z

213

The impacts of urbanization on endangered florida key deer  

E-Print Network [OSTI]

for resources between man and wildlife continues, it is important to understand the effects of urbanization on species. Endangered Key deer (Odocoileus virginianus clavium) are endemic to the Florida Keys archipelago stretching southwest off the southern tip...

Harveson, Patricia Moody

2006-04-12T23:59:59.000Z

214

Residential Energy Efficiency Financing: Key Elements of Program Design  

Broader source: Energy.gov [DOE]

Presents key programmatic elements and context of financing initiatives, including contractor support, rebates, quality assurance, and more.

215

THUMBS DOWN ON DRUG WAR WEAPON  

Science Journals Connector (OSTI)

THUMBS DOWN ON DRUG WAR WEAPON ... Mycoherbicides have been viewed as a potentially potent weapon in the worldwide war on illicit drugs. ...

CHERYL HOGUE

2011-12-05T23:59:59.000Z

216

Plan to speed up drug review approved  

Science Journals Connector (OSTI)

Plan to speed up drug review approved ... Proposed changes in the New Drug Application procedure will shorten review times, reduce paperwork, and save money ...

DAVID HANSON

1982-07-12T23:59:59.000Z

217

Photosensitizer Conjugates For Pathogen Targeting  

DOE Patents [OSTI]

Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.

Hasan, Tayyaba (Arlington, MA); Hamblin, Michael R. (Revere, MA); Soukos, Nikos (Revere, MA)

2002-10-08T23:59:59.000Z

218

POLARIZED TARGET EXPERIMENT AT FERMILAB  

E-Print Network [OSTI]

on Experiment 61 at Fermilab, which is a large collaborationBernie Sandler, From From Fermilab. Alan Jonckheere andTARGET EXPERIMENT AT FERMILAB Owen Chamberlain January 1977

Chamberlain, O.

2010-01-01T23:59:59.000Z

219

Non-PGM Target Update  

Broader source: Energy.gov (indexed) [DOE]

etc. * Volumetric activity no longer part of the metrics * No iR correction * No Tafel extrapolation to the reference potential (voltage) * Fuel cell performance targets on...

220

Type-Based Analysis of Generic Key Management APIs  

E-Print Network [OSTI]

Type-Based Analysis of Generic Key Management APIs Pedro Ad~ao1,2 , Riccardo Focardi3, Universit`a Ca' Foscari, Venezia, Italy Abstract In the past few years, cryptographic key management APIs. In fact, real APIs provide mechanisms to declare the intended use of keys but they are not strong enough

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

A Key Enzyme to the Potency of an Anticancer Agent  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

will provide a new "road map" for furthering S. tropica's drug development potential. Reaction catalyzed by SalL, a chlorinase involved in salinosporamide A biosynthesis. Over...

222

A Target-Oriented Magnetotelluric Inversion Approach For Characterizing The  

Open Energy Info (EERE)

Target-Oriented Magnetotelluric Inversion Approach For Characterizing The Target-Oriented Magnetotelluric Inversion Approach For Characterizing The Low Enthalpy Gross Schonebeck Geothermal Reservoir Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Journal Article: A Target-Oriented Magnetotelluric Inversion Approach For Characterizing The Low Enthalpy Gross Schonebeck Geothermal Reservoir Details Activities (0) Areas (0) Regions (0) Abstract: Electrical conductivity is a key parameter for the exploration and characterization of geothermal reservoirs as hot mineralized formation water of active geothermal areas usually exhibits significantly higher conductivity than the surrounding host rock. Here we present results of a magnetotelluric (MT) exploration experiment carried out in the vicinity of the Gross Schonebeck geothermal test site in Northern Germany, where a

223

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts November 29, 2011 - 4:34pm Addthis THE WHITE HOUSE Office of the Press Secretary FOR IMMEDIATE RELEASENovember 29, 2011 President Obama Announces More Key Administration Posts WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Frederick "Rick" Barton - Assistant Secretary for Conflict and Stabilization Operations and Coordinator for Reconstruction and Stabilization, Department of State Arun Majumdar - Under Secretary of Energy, Department of Energy Marie F. Smith - Member, Social Security Advisory Board The President also announced his intent to appoint the following

224

Magnetized Target Fusion Collaboration. Final report  

SciTech Connect (OSTI)

Nuclear fusion has the potential to satisfy the prodigious power that the world will demand in the future, but it has yet to be harnessed as a practical energy source. The entry of fusion as a viable, competitive source of power has been stymied by the challenge of finding an economical way to provide for the confinement and heating of the plasma fuel. It is the contention here that a simpler path to fusion can be achieved by creating fusion conditions in a different regime at small scale (~ a few cm). One such program now under study, referred to as Magnetized Target Fusion (MTF), is directed at obtaining fusion in this high energy density regime by rapidly compressing a compact toroidal plasmoid commonly referred to as a Field Reversed Configuration (FRC). To make fusion practical at this smaller scale, an efficient method for compressing the FRC to fusion gain conditions is required. In one variant of MTF a conducting metal shell is imploded electrically. This radially compresses and heats the FRC plasmoid to fusion conditions. The closed magnetic field in the target plasmoid suppresses the thermal transport to the confining shell, thus lowering the imploding power needed to compress the target. The undertaking described in this report was to provide a suitable target FRC, as well as a simple and robust method for inserting and stopping the FRC within the imploding liner. The FRC must also survive during the time it takes for the metal liner to compress the FRC target. The initial work at the UW was focused on developing adequate preionization and flux trapping that were found to be essential in past experiments for obtaining the density, flux and most critically, FRC lifetime required for MTF. The timescale for testing and development of such a source can be rapidly accelerated by taking advantage of a new facility funded by the Department of Energy. At this facility, two inductive plasma accelerators (IPA) were constructed and tested. Recent experiments with these IPAs have demonstrated the ability to rapidly form, accelerate and merge two hypervelocity FRCs into a compression chamber. The resultant FRC that was formed was hot (T{sub ion} ~ 400 eV), stationary, and stable with a configuration lifetime several times that necessary for the MTF liner experiments. The accelerator length was less than 1 meter, and the time from the initiation of formation to the establishment of the final equilibrium was less than 10 microseconds. With some modification, each accelerator can be made capable of producing FRCs suitable for the production of the target plasma for the MTF liner experiment. Based on the initial FRC merging/compression results, the design and methodology for an experimental realization of the target plasma for the MTF liner experiment can now be defined. The construction and testing of the key components for the formation of the target plasma at the Air Force Research Laboratory (AFRL) will be performed on the IPA experiment, now at MSNW. A high density FRC plasmoid will be formed and accelerated out of each IPA into a merging/compression chamber similar to the imploding liner at AFRL. The properties of the resultant FRC plasma (size, temperature, density, flux, lifetime) will be obtained. The process will be optimized, and a final design for implementation at AFRL will be carried out. When implemented at AFRL it is anticipated that the colliding/merging FRCs will then be compressed by the liner. In this manner it is hoped that ultimately a plasma with ion temperatures reaching the 10 keV range and fusion gain near unity can be obtained.

John Slough

2012-04-18T23:59:59.000Z

225

Secret key distillation from shielded two-qubit states  

E-Print Network [OSTI]

The quantum states corresponding to a secret key are characterized using the so-called private states, where the key part consisting of a secret key is shielded by the additional systems. Based on the construction, it was shown that a secret key can be distilled from bound entangled states. In this work, I consider the shielded two-qubit states in a key-distillation scenario and derive the conditions under which a secret key can be distilled using the recurrence protocol or the two-way classical distillation, advantage distillation together with one-way postprocessing. From the security conditions, it is shown that a secret key can be distilled from bound entangled states in a much wider range. In addition, I consider the case that in which white noise is added to quantum states and show that the classical distillation protocol still works despite a certain amount of noise although the recurrence protocol does not.

Joonwoo Bae

2008-03-03T23:59:59.000Z

226

Secret key distillation from shielded two-qubit states  

SciTech Connect (OSTI)

The quantum states corresponding to a secret key are characterized using the so-called private states, where the key part consisting of a secret key is shielded by the additional systems. Based on the construction, it was shown that a secret key can be distilled from bound entangled states. In this work, I consider the shielded two-qubit states in a key-distillation scenario and derive the conditions under which a secret key can be distilled using the recurrence protocol or the two-way classical distillation, advantage distillation together with one-way postprocessing. From the security conditions, it is shown that a secret key can be distilled from bound entangled states in a much wider range. In addition, I consider the case that in which white noise is added to quantum states and show that the classical distillation protocol still works despite a certain amount of noise although the recurrence protocol does not.

Bae, Joonwoo [School of Computational Sciences, Korea Institute for Advanced Study, Seoul 130-722 (Korea, Republic of)

2010-05-15T23:59:59.000Z

227

The overdose of drugs in Japan  

Science Journals Connector (OSTI)

... spenders on prescription drugs. Among the top-selling drugs are anti-cancer agents peculiar to Japan that are of questionable efficacy and yet have sales of hundreds of millions of dollars ... -cancer drugs in other developed nations. Moreover, several of the drugs sold only in Japan have serious side effects. Justification of these contentions is to be found in Tables ...

Masanori Fukushima

1989-12-28T23:59:59.000Z

228

Polypharmacology Modelling Using Proteochemometrics (PCM): Recent Methodological Developments, Applications to Target Families, and Future Prospects  

E-Print Network [OSTI]

to be in the order of $1.8 billion per drug. In addition, price pressure from health care providers has been increasing and there is a growing relevance of more targeted medicine. Hence, the ‘blockbuster model’ of the pharmaceutical industry is being challenged.1...

Cortés-Ciriano, Isidro; ul Ain, Qurrat; Subramanian, Vigneshwari; Lenselink, Eelke B.; Méndez-Lucio, Oscar; IJzerman, Adriaan P.; Wohlfahrt, Gerd; Prusis, Peteris; Malliavin, Thérèse E.; van Westen, Gerard J. P.; Bender, Andreas

2014-10-07T23:59:59.000Z

229

Computer modeling reveals how surprisingly potent hepatitis C drug works  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hepatitis C computer modeling Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

230

EIA Data: 2011 United States Residential Sector Key Indicators and  

Open Energy Info (EERE)

Residential Sector Key Indicators and Residential Sector Key Indicators and Consumption Dataset Summary Description This dataset is the 2011 United States Residential Sector Key Indicators and Consumption, part of the Annual Energy Outlook that highlights changes in the AEO Reference case projections for key energy topics. Source EIA Date Released December 16th, 2010 (4 years ago) Date Updated Unknown Keywords consumption EIA energy residential sector key indicators Data application/vnd.ms-excel icon Residential Sector Key Indicators and Consumption (xls, 62.5 KiB) Quality Metrics Level of Review Peer Reviewed Comment Temporal and Spatial Coverage Frequency Annually Time Period License License Open Data Commons Public Domain Dedication and Licence (PDDL) Comment http://www.eia.gov/abouteia/copyrights_reuse.cfm

231

Countdown to Fixed Target INSIDE  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

17, 1996 17, 1996 Number 10 Countdown to Fixed Target INSIDE 2 University Close-Up: The University of Illinois 4 Tollestrup Elected to National Academy 5 Bardeen Receives Sakurai Prize 6 Take Your Daughters and Sons to Work Day "At this moment," Fermilab Director John Peoples told the House Subcommittee on Energy and Environment in testimony deliv- ered in Washington on May 8, "Fermilab is in the midst of the transition from collider opera- tions to fixed-target operations. In June, we will begin extracting a beam of protons from the Tevatron, the highest-energy external beam in the world. By directing this beam onto eight targets we will create eight distinct particle beams that will in turn support 10 unique experiments. Although fixed-target experi- ments cannot explore the high-energy frontier

232

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts May 28, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Gordon Heddell, Inspector General, Department of Defense; Ellen Murray, Assistant Secretary for Resources and Technology, Department of Health and Human Services; Polly Trottenberg, Assistant Secretary for Transportation Policy, Department of Transportation; and James J. Markowsky, Assistant Secretary for Fossil Energy, Department of Energy. President Obama said, "Each of these individuals brings extensive expertise in their chosen fields, and they are joining my administration at a time

233

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts April 17, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Christine M. Griffin, Deputy Director of Office of Personnel Management; Kevin Concannon, Under Secretary for Food, Nutrition and Consumer Services, United States Department of Agriculture; Rajiv Shah, Under Secretary for Research, Education, and Economics, United States Department of Agriculture; Michael Nacht, Assistant Secretary of Defense (Global Strategic Affairs), Department of Defense; Mercedes Márquez, Assistant Secretary for Community Planning and Development, Department of Housing and

234

Florida Keys Electric Cooperative - Residential Rebate Program | Department  

Broader source: Energy.gov (indexed) [DOE]

Florida Keys Electric Cooperative - Residential Rebate Program Florida Keys Electric Cooperative - Residential Rebate Program Florida Keys Electric Cooperative - Residential Rebate Program < Back Eligibility Residential Savings Category Home Weatherization Commercial Weatherization Sealing Your Home Heating & Cooling Commercial Heating & Cooling Cooling Insulation Design & Remodeling Windows, Doors, & Skylights Program Info State Florida Program Type Utility Rebate Program Rebate Amount Rebates $25 - $500, max $1000 per member Florida Keys Electric Cooperative offers residential members rebates for installing energy efficient measures. To qualify for rebates, members must first call FKEC and make an appointment for a free home energy audit. An FKEC trained auditor will assess the home and make recommendations for

235

Vehicle Technologies Office: Key Activities in Vehicles | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

in four key areas to develop and deploy vehicle technologies that reduce the use of petroleum while maintaining or improving performance, power, and comfort. Research and...

236

PPPL scientists take key step toward solving a major astrophysical...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Primary tabs View(active tab) High Resolution Press Releases PPPL scientists take key step toward solving a major astrophysical mystery By John Greenwald September 10, 2014 Tweet...

237

PPPL scientists take key step toward solving a major astrophysical...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Primary tabs View(active tab) High Resolution News PPPL scientists take key step toward solving a major astrophysical mystery By John Greenwald September 10, 2014 Tweet Widget...

238

Researchers find potential key for unlocking biomass energy  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Unlocking biomass energy Researchers find potential key for unlocking biomass energy Potential pretreatment method that can make plant cellulose five times more digestible by...

239

Key Practical Issues in Strengthening Safety Culture, INSAG-15...  

Broader source: Energy.gov (indexed) [DOE]

A Report by the International Nuclear Safety Advisory Group, International Atomic Energy Agency, Vienna, 2002. Key Practical Issues in Strengthening Safety Culture, INSAG-15,...

240

LANL breaks ground on key sediment control project  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sediment control project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately 2 million features are up to eight feet high and...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Sandia completes major overhaul of key nuclear weapons test facilities...  

National Nuclear Security Administration (NNSA)

completes major overhaul of key nuclear weapons test facilities | National Nuclear Security Administration People Mission Managing the Stockpile Preventing Proliferation Powering...

242

Key Facts about the Biosciences Division | Argonne National Laboratory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to understand biological mechanisms relevant to bioremediation, climate change, energy production, and the protection of human health. BiosciencesDivisionKeyFactsOct2014...

243

Keys to Successful Feedback - John Settle PowerPoint Presentation...  

Office of Environmental Management (EM)

Transportation of Radioactive Materials Keys to Successful Feedback - John Settle PowerPoint Presentation Leadership Development Readings May 14, 2014 - "Your Brain on Conflict"...

244

Water dynamics clue to key residues in protein folding  

SciTech Connect (OSTI)

A computational method independent of experimental protein structure information is proposed to recognize key residues in protein folding, from the study of hydration water dynamics. Based on all-atom molecular dynamics simulation, two key residues are recognized with distinct water dynamical behavior in a folding process of the Trp-cage protein. The identified key residues are shown to play an essential role in both 3D structure and hydrophobic-induced collapse. With observations on hydration water dynamics around key residues, a dynamical pathway of folding can be interpreted.

Gao, Meng [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Zhu, Huaiqiu, E-mail: hqzhu@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Yao, Xin-Qiu [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China) [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Department of Biophysics, Kyoto University, Sakyo Kyoto 606-8502 (Japan); She, Zhen-Su, E-mail: she@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)

2010-01-29T23:59:59.000Z

245

Hydrodynamic experiment provides key data for Stockpile Stewardship  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

predictively model and assess weapon performance in the absence of full-scale underground nuclear testing," said Webster. Los Alamos hydrodynamic experiment provides key data for...

246

Livermore highlights key accomplishments in annual report | National...  

National Nuclear Security Administration (NNSA)

highlights key accomplishments in annual report | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing...

247

IPNS enriched uranium booster target  

SciTech Connect (OSTI)

Since startup in 1981, IPNS has operated on a fully depleted /sup 238/U target. With the booster as in the present system, high energy protons accelerated to 450 MeV by the Rapid Cycling Synchrotron are directed at the target and by mechanisms of spallation and fission of the uranium, produce fast neutrons. The neutrons from the target pass into adjacent moderator where they slow down to energies useful for spectroscopy. The target cooling systems and monitoring systems have operated very reliably and safely during this period. To provide higher neutron intensity, we have developed plans for an enriched uranium (booster) target. HETC-VIM calculations indicate that the target will produce approx.90 kW of heat, with a nominal x5 gain (k/sub eff/ = 0.80). The neutron beam intensity gain will be a factor of approx.3. Thermal-hydraulic and heat transport calculations indicate that approx.1/2 in. thick /sup 235/U discs are subject to about the same temperatures as the present /sup 238/U 1 in. thick discs. The coolant will be light demineralized water (H/sub 2/O) and the coolant flow rate must be doubled. The broadening of the fast neutron pulse width should not seriously affect the neutron scattering experiments. Delayed neutrons will appear at a level about 3% of the total (currently approx.0.5%). This may affect backgrounds in some experiments, so that we are assessing measures to control and correct for this (e.g., beam tube choppers). Safety analyses and neutronic calculations are nearing completion. Construction of the /sup 235/U discs at the ORNL Y-12 facility is scheduled to begin late 1985. The completion of the booster target and operation are scheduled for late 1986. No enriched uranium target assembly operating at the projected power level now exists in the world. This effort thus represents an important technological experiment as well as being a ''flux enhancer''.

Schulke, A.W. Jr.

1985-01-01T23:59:59.000Z

248

Economic Life Cycle Assessment as element of sustainability certification – a key success factor moving beyond Life Cycle Costing  

E-Print Network [OSTI]

Target topic: achieving sustainability, saving energy, and improving occupant comfort? Lead Author Wolfram Trinius, PhD, Ingenieurb?ro Trinius, Hamburg, Germany and University of Gavle, Sweden Co Authors Harry Hirsch, HH Consulting, Baden... Baden, Germany Simone Lakenbrink, DU Diederichs Project Management, Munich, Germany Title Economic Life Cycle Assessment as element of sustainability certification ? a key success factor moving beyond Life Cycle Costing The move from...

Trinius, W.; Hirsch, H.

249

A Fluorescence Displacement Assay for Antidepressant Drug Discovery Based on Ligand-Conjugated Quantum Dots  

SciTech Connect (OSTI)

The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) protein plays a central role in terminating 5-HT neurotransmission and is the most important therapeutic target for the treatment of major depression and anxiety disorders. We report an innovative, versatile, and target-selective quantum dot (QD) labeling approach for SERT in single Xenopus oocytes that can be adopted as a drug-screening platform. Our labeling approach employs a custom-made, QD-tagged indoleamine derivative ligand, IDT318, that is structurally similar to 5-HT and accesses the primary binding site with enhanced human SERT selectivity. Incubating QD-labeled oocytes with paroxetine (Paxil), a high-affinity SERT-specific inhibitor, showed a concentration- and time-dependent decrease in QD fluorescence, demonstrating the utility of our approach for the identification of SERT modulators. Furthermore, with the development of ligands aimed at other pharmacologically relevant targets, our approach may potentially form the basis for a multitarget drug discovery platform.

Chang, Jerry [Vanderbilt University; Tomlinson, Ian [Oak Ridge National Laboratory (ORNL); Warnement, Michael [Vanderbilt University; Iwamoto, Hideki [Vanderbilt University

2011-01-01T23:59:59.000Z

250

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

the Corn Wet Milling Industry: A Guide for Energy and Plantenergy efficiency measures for breweries, 53 cement, 54 corn

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

251

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

Energy (DOE)’s Industrial Assessment Centers, located at 26Generated by the Industrial Assessment Center Program:

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

252

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

of companies with the Danish Energy Agency, were made forMay 29, 2003. Danish Energy Agency, 2000. Green Taxes forDanish CO 2 -Tax Scheme,” in International Energy Agency,

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

253

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

quality management program (ISO 9001:2000) and environmentalquality management system (ISO 9001). It was also found that

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

254

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

implementation of the EMS is the similarity with other management systems, like environmental management system and the quality management system (ISO 9001).

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

255

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

of industrial primary energy consumption in The Netherlands.included total primary energy consumption for twelve typeswas converted into primary energy consumption and the energy

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

256

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

Institute for Energy Efficiency, Norway) and CRES (CenterInstitute for Energy Efficiency, Norway) and CRES (Centermembers, 48 Norway’s Industrial Energy Efficiency Network

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

257

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

and Quality Control that discusses energy auditor training,authorization of energy auditors, and quality control ofevaluation, energy audit models, and auditor tools based on

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

258

International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs  

E-Print Network [OSTI]

less than six years. The energy audits were carried out byyears, as identified in an energy audit or through internalthe following: 86 1. Energy audit and analysis. The company

Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

2008-01-01T23:59:59.000Z

259

Pseudomonas aeruginosa biofilm: Potential therapeutic targets  

Science Journals Connector (OSTI)

Abstract Pseudomonas aeruginosa is a gram-negative pathogen that has become an important cause of infection, especially in patients with compromised host defense mechanisms. It is frequently related to nosocomial infections such as pneumonia, urinary tract infections (UTIs) and bacteremia. The biofilm formed by the bacteria allows it to adhere to any surface, living or non-living and thus Pseudomonal infections can involve any part of the body. Further, the adaptive and genetic changes of the micro-organisms within the biofilm make them resistant to all known antimicrobial agents making the Pseudomonal infections complicated and life threatening. Pel, Psl and Alg operons present in P. aeruginosa are responsible for the biosynthesis of extracellular polysaccharide which plays an important role in cell–cell and cell–surface interactions during biofilm formation. Understanding the bacterial virulence which depends on a large number of cell-associated and extracellular factors is essential to know the potential drug targets for future studies. Current novel methods like small molecule based inhibitors, phytochemicals, bacteriophage therapy, photodynamic therapy, antimicrobial peptides, monoclonal antibodies and nanoparticles to curtail the biofilm formed by P. aeruginosa are being discussed in this review.

Garima Sharma; Saloni Rao; Ankiti Bansal; Shweta Dang; Sanjay Gupta; Reema Gabrani

2014-01-01T23:59:59.000Z

260

Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance  

E-Print Network [OSTI]

as: Wu: Drug metabolizing enzyme activities versus geneticRoles for Old Molecules: Enzymes in Personalized Medicine,Access Drug metabolizing enzyme activities versus genetic

Wu, Alan HB

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Secure password-based authenticated key exchange for web services  

Science Journals Connector (OSTI)

This paper discusses an implementation of an authenticated key-exchange method rendered on message primitives defined in the WS-Trust and WS-SecureConversation specifications. This IEEE-specified cryptographic method (AuthA) is proven-secure for password-based ... Keywords: authenticated key exchange, password, security, web services

Liang Fang; Samuel Meder; Olivier Chevassut; Frank Siebenlist

2004-10-01T23:59:59.000Z

262

Prairie Fruit Summary, 2010 Some key considerations for the homeowner  

E-Print Network [OSTI]

1 Prairie Fruit Summary, 2010 Some key considerations for the homeowner by Bob Bors The following list highlights some key positive (+), negative (-) and variable ( ± ) attributes for growing fruit into account. For more info visit: www.fruit.usask.ca Haskap/Blue Honeysuckle: - All varieties are very cold

Peak, Derek

263

Efficient Hybrid Key Agreement Protocol for Wireless Ad Hoc Networks  

E-Print Network [OSTI]

Efficient Hybrid Key Agreement Protocol for Wireless Ad Hoc Networks Xiang-Yang Li Yu Wang Ophir important aspects in ad-hoc wireless networks. To ensure the security, several cryptography protocols must efficient when applied to wireless ad-hoc networks. In this paper, we propose a key agreement protocol

Wang, Yu

264

Electricity and Development: Global Trends and Key Challenges  

E-Print Network [OSTI]

Electricity and Development: Global Trends and Key Challenges Romeo Pacudan, PhD Risoe National · Prospects for electricity development · Investment requirements · Key challenges · Final remarks #12 and the transport burden in Tanzania. Source: Modi, 2004 #12;2. Energy and Human Development Access to electricity

265

Development of a Public Key Infrastructure across Multiple Enterprises  

Science Journals Connector (OSTI)

Main-stream applications are beginning to incorporate public key cryptography. It can be difficult to deploy this technology without a robust infrastructure to support it. It can also be difficult to deploy a public key infra-structure among multiple ...

B. J. Desind; T. M. Sharick; J. P. Long; B. J. Wood

1997-06-01T23:59:59.000Z

266

Relations among Privacy Notions for Signcryption and Key Invisible  

E-Print Network [OSTI]

Relations among Privacy Notions for Signcryption and Key Invisible "Sign-then-Encrypt" Yang Wang1 invisibility to protect the identities of signcryption users and were able to prove that key invisibility invisibility implies ciphertext anonymity without any additional restrictions. More surprisingly, we prove

Manulis, Mark

267

Practical Key-Recovery for All Possible Parameters of SFLASH  

E-Print Network [OSTI]

function over a finite field. However, unlike RSA this power function is an easy-to-invert bijec- tion a new practical key-recovery attack on the SFLASH signature scheme. SFLASH is a derivative of the older from the public-key. The attack uses new crypt- analytic tools, most notably pencils of matrices

Fouque, Pierre-Alain

268

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

More Key Administration Posts More Key Administration Posts President Obama Announces More Key Administration Posts July 8, 2011 - 12:00am Addthis THE WHITE HOUSE Office of the Press Secretary WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Michael A. Hammer, Assistant Secretary for Public Affairs, Department of State Charles McConnell, Assistant Secretary for Fossil Energy, Department of Energy The President also announced his intent to appoint the following individuals to key Administration posts: Terry Guen, Member, Advisory Council on Historic Preservation Dorothy T. Lippert, Member, Advisory Council on Historic Preservation Rosemary A. Joyce, Member, Cultural Property Advisory Committee President Obama said, "Our nation will be greatly served by the talent and

269

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Key Dates Key Dates Albert Einstein Distinguished Educator Fellowship (AEF) Program Einstein Fellowship Home Eligibility Benefits Obligations How to Apply Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A RSS Feeds FeedbackShare Page Key Dates for the 2014-2015 Einstein Fellowship Application process. On-line Application Opens September 24, 2013 Application Deadline 5:00pm EST December 4, 2013 Application Review 7-8 weeks Notification to Semi-Finalists [Travel Arrangements made for Interviews in Washington, DC] Late January 2014 Interviews in Washington, DC February 23-25, 2014 Finalists Notifications March 2014 Congressional Fellows Placement Interviews June - July 2014 Fellows Arrive in Washington, DC August 2014 Orientation meeting for the 2014-2015 Einstein Fellows

270

Apparatus, system, and method for synchronizing a timer key  

DOE Patents [OSTI]

A timer key relating to monitoring a countdown time of a countdown routine of an electronic device is disclosed. The timer key comprises a processor configured to respond to a countdown time associated with operation of the electronic device, a display operably coupled with the processor, and a housing configured to house at least the processor. The housing has an associated structure configured to engage with the electronic device to share the countdown time between the electronic device and the timer key. The processor is configured to begin a countdown routine based at least in part on the countdown time, wherein the countdown routine is at least substantially synchronized with a countdown routine of the electronic device when the timer key is removed from the electronic device. A system and method for synchronizing countdown routines of a timer key and an electronic device are also disclosed.

Condit, Reston A; Daniels, Michael A; Clemens, Gregory P; Tomberlin, Eric S; Johnson, Joel A

2014-04-22T23:59:59.000Z

271

NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes  

E-Print Network [OSTI]

* Corresponding author. E-mail: a.ciulli@dundee.ac.uk M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 2 1. Introduction A major purpose of academic and pharmaceutical drug development research is to identify natural or synthetic molecules that interact both... , happening both in academy and industry, in our perspective on what are the most relevant targets on which to focus drug discovery efforts, it becomes important that target ligandability is assessed in the best possible way. By optimizing protein...

Dias, David M.; Ciulli, Alessio

2014-08-28T23:59:59.000Z

272

Target GmbH | Open Energy Information  

Open Energy Info (EERE)

Target GmbH Jump to: navigation, search Name: Target GmbH Place: Germany Sector: Efficiency, Solar Product: German company with interests in solar and energy efficiency....

273

Adulteration of Drugs-of-Abuse Specimens  

Science Journals Connector (OSTI)

Persons abusing drugs attempt to adulterate urine specimens in ... fluid and various detoxifying agents available through the Internet is a common practice. Household chemicals such ... mask drug testing if the c...

Amitava Dasgupta

2005-01-01T23:59:59.000Z

274

Vetting Threats To Safe Drug Supplies  

Science Journals Connector (OSTI)

Vetting Threats To Safe Drug Supplies ... Representatives from government, drug companies, and national and international law enforcement agencies struggled to characterize what all agree is a large, growing, and frustratingly nebulous threat to public health and safety. ...

RICK MULLIN

2012-04-01T23:59:59.000Z

275

Prostate drug Proscar cleared for marketing  

Science Journals Connector (OSTI)

Prostate drug Proscar cleared for marketing ... The Food & Drug Administration has approved marketing of a pill developed by Merck & Co., Rahway, N.J., as an alternative to surgery for treating enlargement of the prostate gland. ...

STEPHEN STINSON

1992-06-29T23:59:59.000Z

276

Progress with developing a target for magnetized target fusion  

SciTech Connect (OSTI)

Magnetized Target Fusion (MTF) is an approach to fusion where a preheated and magnetized plasma is adiabatically compressed to fusion conditions. Successful MTF requires a suitable initial target plasma with an embedded magnetic field of at least 5 T in a closed-field-line topology, a density of roughly 10{sup 18} cm{sup {minus}3}, a temperature of at least 50 eV, and must be free of impurities which would raise radiation losses. Target plasma generation experiments are underway at Los Alamos National Laboratory using the Colt facility; a 0.25 MJ, 2--3 {micro}s rise-time capacitor bank. The goal of these experiments is to demonstrate plasma conditions meeting the minimum requirements for a MTF initial target plasma. In the first experiments, a Z-pinch is produced in a 2 cm radius by 2 cm high conducting wall using a static gas-fill of hydrogen or deuterium gas in the range of 0.5 to 2 torr. Thus far, the diagnostics include an array of 12 B-dot probes, framing camera, gated OMA visible spectrometer, time-resolved monochrometer, filtered silicon photodiodes, neutron yield, and plasma-density interferometer. These diagnostics show that a plasma is produced in the containment region that lasts roughly 10 to 20 {micro}s with a maximum plasma density exceeding 10{sup 18} cm{sup {minus}3}. The experimental design and data are presented.

Wysocki, F.J.; Chrien, R.E.; Idzorek, G.; Oona, H.; Whiteson, D.O.; Kirkpatrick, R.C.; Lindemuth, I.R.; Sheehey, P.T.

1997-09-01T23:59:59.000Z

277

Protein-Based Nanomedicine Platforms for Drug Delivery. | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Protein-Based Nanomedicine Platforms for Drug Delivery. Protein-Based Nanomedicine Platforms for Drug Delivery. Abstract: Drug delivery systems have been developed for many years,...

278

The pipeline and future of drug development in schizophrenia  

E-Print Network [OSTI]

The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

Gray, J A; Roth, B L

2007-01-01T23:59:59.000Z

279

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

280

Authenticated group Diffie-Hellman key exchange: theory and practice  

SciTech Connect (OSTI)

Authenticated two-party Diffie-Hellman key exchange allows two principals A and B, communicating over a public network, and each holding a pair of matching public/private keys to agree on a session key. Protocols designed to deal with this problem ensure A (B resp.)that no other principals aside from B (A resp.) can learn any information about this value. These protocols additionally often ensure A and B that their respective partner has actually computed the shared secret value. A natural extension to the above cryptographic protocol problem is to consider a pool of principals agreeing on a session key. Over the years several papers have extended the two-party Diffie-Hellman key exchange to the multi-party setting but no formal treatments were carried out till recently. In light of recent developments in the formalization of the authenticated two-party Diffie-Hellman key exchange we have in this thesis laid out the authenticated group Diffie-Hellman key exchange on firmer foundations.

Chevassut, Olivier

2002-10-03T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Automatic UAV Landing with Ground Target Maintained in the Field of View  

E-Print Network [OSTI]

Automatic UAV Landing with Ground Target Maintained in the Field of View Laurent Burlion and Henry de Plinval Abstract In this paper, a key feature for UAV visual servoing in automatic land- ing. First, a control law for UAV automatic landing is proposed. Then, the output con- straint method

282

Radioactive target needs for nuclear reactor physics and nuclear astrophysics , G. Barreau1  

E-Print Network [OSTI]

Radioactive target needs for nuclear reactor physics and nuclear astrophysics B.Jurado1* , G Gradignan, France 2 IPN, CNRS/IN2P3, Univ. Paris-Sud, 91405 Orsay, France Abstract: Nuclear reaction cross sections of short-lived nuclei are key inputs for new generation nuclear reactor simulations and for models

Boyer, Edmond

283

METHOD AND TOOLS TO MEET ENERGY EFFICIENCY TARGETS AT PRODUCT DESIGN STAGE  

E-Print Network [OSTI]

METHOD AND TOOLS TO MEET ENERGY EFFICIENCY TARGETS AT PRODUCT DESIGN STAGE Guillaume MOENNE Energy consumption is a key topic for electr(on)ic products, due to growing regulations & sensibility of final consumers. Developments are possible to reduce energy consumption of products during use phase

Paris-Sud XI, Université de

284

Life Pure Fusion Target Designs: Status and Prospects  

SciTech Connect (OSTI)

Analysis and radiation-hydrodynamics simulations for expected high-gain fusion target performance on a demonstration 1-GWe Laser Inertial Fusion Energy (LIFE) power plant are presented. The required laser energy driver is 2.2 MJ at a 0.351-{mu}m wavelength, and a fusion target gain greater than 60 at a repetition rate of 16 Hz is the design goal for economic and commercial attractiveness. A scaling-law analysis is developed to benchmark the design parameter space for hohlraum-driven central hot-spot ignition. A suite of integrated hohlraum simulations is presented to test the modeling assumptions and provide a basis for near-term experimental resolution of the key physics uncertainties on the National Ignition Facility.

Amendt, P; Dunne, M; Ho, D; Lindl, J

2011-10-20T23:59:59.000Z

285

Iontophoretic drug delivery system: A review  

Science Journals Connector (OSTI)

Among the recent developments in the field of transdermal drug delivery, iontophoresis has emerged as a very promising tool for this purpose. Various studies have been performed on drug delivery through the skin using electric current. Iontophoresis ... Keywords: Iontophoresis, iontophoretic systems, transdermal drug delivery

Ajay Semalty; Mona Semalty; Ranjit Singh; Shailendra K. Saraf; Shubhini Saraf

2007-09-01T23:59:59.000Z

286

The Electricity Transmission System Opportunities to Overcome Key Challenges  

Broader source: Energy.gov (indexed) [DOE]

Opportunities to Overcome Key Challenges Opportunities to Overcome Key Challenges Summary Results of Breakout Group Discussions Electricity Transmission Workshop Double Tree Crystal City, Arlington, Virginia November 2, 2012 Breakout Group Discussion Overview Opportunities to Overcome Key Challenges Each of the four breakout groups prioritized the critical issues facing the grid from the list of synthesized challenges identified in the first breakout session of the workshop. Focusing on these top priorities, each group proposed specific R&D activities and initiatives that DOE can pursue to overcome these challenges and address existing gaps. Summary of Synthesized Challenges A. Need improved understanding of the availability, utility, maintenance, exchange, and security of data and associated requirements.

287

Development of a public key infrastructure across multiple enterprises  

SciTech Connect (OSTI)

Main-stream applications are beginning to incorporate public key cryptography. It can be difficult to deploy this technology without a robust infrastructure to support it. It can also be difficult to deploy a public key infrastructure among multiple enterprises when different applications and standards must be supported. This discussion chronicles the efforts by a team within the US Department of Energy`s Nuclear Weapons Complex to build a public key infrastructure and deploy applications that use it. The emphasis of this talk will be on the lessons learned during this effort and an assessment of the overall impact of this technology.

Sharick, T.M.; Long, J.P.; Desind, B.J. [and others

1997-05-01T23:59:59.000Z

288

Targets  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

wall must be eliminated. Meeting this standard requires assembly in a Class 100 cleanroom. The capsule is fitted inside a hohlraum cylinder measuring 9 millimeters high by 5...

289

Targeting ion transport in cancer  

Science Journals Connector (OSTI)

...tumor hypoxia, survival pathway and therapy target. Cell Cycle 3, 164-167. ( doi:10.4161/cc.3.2.618 ) 73 Rademakers, SE , Lok, J, van der Kogel, AJ, Bussink, J, Kaanders, JH. 2011 Metabolic markers in relation to hypoxia; staining...

2014-01-01T23:59:59.000Z

290

RADIATION ONCOLOGY TARGET YOUR FUTURE  

E-Print Network [OSTI]

. · Radiation therapist - a health professional who designs, calculates (plans) and provides the radiation dose and monitors the delivery of radiation therapy, taking into account the protection and safety of patientsRADIATION ONCOLOGY TARGET YOUR FUTURE #12;A Career in Radiation Oncology YOUR CHOICE SAVE LIVES

Tobar, Michael

291

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

D. F. , Kahl, S. B. , Bjornstad, K. A. , Bauer, W. F. ,L. , Blakely, E. A. , Bjornstad, K. A. , Deen, D. F. ,Blakely 2 , Kathleen A. Bjornstad 2 , Xiao Shu 3 ,Thomas F.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

292

Rational Design of the Microtubule-Targeting Anti–Breast Cancer Drug EM015  

Science Journals Connector (OSTI)

...spectra were recorded at 400 MHz and referenced with residual...spectra were recorded at 100 MHz and referenced with 77...conducted under dry argon atmosphere and monitored by TLC using...the interface between plasma and Histopaque-1077...1 1H NMR (CDCl3, 400 MHz): delta 7.14 (d...

Ritu Aneja; Manu Lopus; Jun Zhou; Surya N. Vangapandu; Amr Ghaleb; Joyce Yao; James H. Nettles; Binfei Zhou; Meenakshi Gupta; Dulal Panda; Ramesh Chandra; and Harish C. Joshi

2006-04-01T23:59:59.000Z

293

An In vivo Tumor Model Exploiting Metabolic Response as a Biomarker for Targeted Drug Development  

Science Journals Connector (OSTI)

...0-1.8). Energy imbalance may play a role in the development of aggressive...methods of dual-energy X-ray absorptiometry...human research ethics committee of...0-1.8). Energy imbalance may play a role in the development of aggressive...

Carleen Cullinane; Donna S. Dorow; Maya Kansara; Nelly Conus; David Binns; Rodney J. Hicks; Leonie K. Ashman; Grant A. McArthur; and David M. Thomas

2005-11-01T23:59:59.000Z

294

Supervised prediction of drug–target interactions using bipartite local models  

Science Journals Connector (OSTI)

......performance for the nuclear receptor dataset Method AUC AUPR KRMd...on four benchmark datasets: (a) enzyme...c) GPCR and (d) nuclear receptor. The solid...interactions for the nuclear receptor dataset obtained using our......

Kevin Bleakley; Yoshihiro Yamanishi

2009-09-15T23:59:59.000Z

295

Prediction of drug–target interaction networks from the integration of chemical and genomic spaces  

Science Journals Connector (OSTI)

......Supplementary information: Datasets and all prediction...GPCRs), and nuclear receptors. Through...removed from the dataset. The data statistics...Ion channel GPCR Nuclear receptor No. of...Supplementary information: Datasets and all prediction...GPCRs), and nuclear receptors. Through......

Yoshihiro Yamanishi; Michihiro Araki; Alex Gutteridge; Wataru Honda; Minoru Kanehisa

2008-07-01T23:59:59.000Z

296

Drug–target interaction prediction by learning from local information and neighbors  

Science Journals Connector (OSTI)

......improvement is achieved on the nuclear receptor dataset, which contains the...receptor (GPCR) and nuclear receptor, respectively. The datasets were downloaded from...interactions of the nuclear receptor dataset produced by BLM-NII......

Jian-Ping Mei; Chee-Keong Kwoh; Peng Yang; Xiao-Li Li; Jie Zheng

2013-01-15T23:59:59.000Z

297

CHARACTERIZATION OF MYCOSIN FAMILY PROTEASES, NOVEL DRUG TARGETS OF MYCOBACTERIUM TUBERCULOSIS  

E-Print Network [OSTI]

WDVtKGSSGQEIAVIDTGVDYTHPDLDGKVIKGYDFVDNDY-DPM---DLNNHGTHVAGIAAAETNNAT 88 MycP1_TB 65 WSNTYLGVADaHKf-ATGAGVTVAVIDTGVDASP---RVPAEPGGDFVD-QA-GNGl-sDCDAHGTLTASIIAGRPAPTD 137 gi 130964 154 IDQRNLPLDNnYSAnFDGTGVTAYVIDTGVNNAHVEFGGRSVSGYDFVDNDAda----sDCNGHGTHVAGTIGGS----- 224 gi 114081 140 IDQRDLPLSNs...YTYtATGRGVNVYVIDTGIRTTHREFGGRARVGYDALGGNGq------DCNGHGTHVAGTIGGV----- 208 gi 124932 24 RGVEMIQAPAvWNQ-TRGRGVKVAVLDTGCDADHPDLKARIIGGrNFTDDDEgDPeifkDYNGHGTHVAGTIAAT-ENEN 101 1THM 13 YGPQKIQAPQaWDI-AEGSGAKIAIVDTGVQSNHPDLAGKVVGGWDFVDNDStp----qNGNGHGTHCAGIAAAVTNNST 87 gi 549004 112 YGISQIKAPAl...

Baird, Hilary

2007-09-17T23:59:59.000Z

298

Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery  

Science Journals Connector (OSTI)

......compiled based on pathway reviews and primary research...was based on published review and research papers...a future version. We plan to update SignaLink every...observed differences in body plans. Among metazoans, these...2001). Two decisive regulatory networks in this case......

Tamás Korcsmáros; Illés J. Farkas; Máté S. Szalay; Petra Rovó; Dávid Fazekas; Zoltán Spiró; Csaba Böde; Katalin Lenti; Tibor Vellai; Péter Csermely

2010-08-15T23:59:59.000Z

299

E-Print Network 3.0 - anti-filarial drug target Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences 24 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: the Pharmaceutical Industry History,...

300

E-Print Network 3.0 - anti-epileptogenic drug targets Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences 19 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: the Pharmaceutical Industry History,...

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Perspective on the Pipeline of Drugs Being Developed with Modulation of DNA Damage as a Target  

Science Journals Connector (OSTI)

...Depth Cancer Centers Work to Optimize Pipelines In recent years, the Valley of Death...Institute/Sam Ogden.] Pushing the Pipeline At MD Anderson's new institute...Corliss Cancer centers work to optimize pipelines. | News

Ruth Plummer

2010-09-15T23:59:59.000Z

302

Optimization of magnetic drug targeting using models of human breast carcinomas  

Science Journals Connector (OSTI)

...treated at each of three magnetic field (energy) levels...111In-ChL6 bioprobes (solid lines) showed 20 and 18 ID...amplitude alternating magnetic fields for heat induction of...cancer treatment with AC magnetic field induced excitation of...

Radhika Karkare and Robert Campbell

2008-05-01T23:59:59.000Z

303

Synuclein-? Targeting Peptide Inhibitor that Enhances Sensitivity of Breast Cancer Cells to Antimicrotubule Drugs  

Science Journals Connector (OSTI)

...reference spectra typical of disordered proteins. ). This is indicative...rapidly inter-converting ensemble, which shows that SNCG is intrinsically disordered. The far-UV CD spectrum...high concentrations of protein and peptide required...

Vinay K. Singh; Yue Zhou; Joseph A. Marsh; Vladimir N. Uversky; Julie D. Forman-Kay; Jingwen Liu; and Zongchao Jia

2007-01-15T23:59:59.000Z

304

Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery  

Science Journals Connector (OSTI)

......research articles and reviews, thus, both experimental...currently no gold standards compiled with similar...based on pathway reviews and primary research...based on published review and research papers...future version. We plan to update SignaLink...network constructed by mining PubMed abstracts......

Tamás Korcsmáros; Illés J. Farkas; Máté S. Szalay; Petra Rovó; Dávid Fazekas; Zoltán Spiró; Csaba Böde; Katalin Lenti; Tibor Vellai; Péter Csermely

2010-08-15T23:59:59.000Z

305

Drug repositioning by integrating target information through a heterogeneous network model  

Science Journals Connector (OSTI)

......receptors occur in central nervous system and play a role in many brain functions. TL_HGBI was able to identify Lorazepam as the...with advanced non-small cell lung cancer with and without brain metastases. a phase II study of the EORTC Lung Cancer Group......

Wenhui Wang; Sen Yang; Xiang Zhang; Jing Li

2014-10-15T23:59:59.000Z

306

Genome-Free Viral Capsids for Targeted Drug Delivery to Breast Cancer  

E-Print Network [OSTI]

Water (ddH 2 O) used in biological procedures or as a reaction solvent was deionized using a NANOpure TM purification system (Water (ddH 2 O) used in biologi- cal procedures or as a reaction solvent was deionized using a NANOpure TM purification system (

Wu, Wesley

2012-01-01T23:59:59.000Z

307

MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells  

E-Print Network [OSTI]

imaging; theranostic nanomedicine; doxorubicin; Rv 6 integrin; superparamagnetic iron oxide; lung cancer

Gao, Jinming

308

Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review  

Science Journals Connector (OSTI)

...defined multivalent inhibitors of the adherence...Chemical modification of chitosan. 3. Hyperbranched chitosan-sialic acid dendrimer...of dendrimerized chitosan-sialic acid hybrid...multivalent ligands and inhibitors. Angew. Chem...

2012-01-01T23:59:59.000Z

309

NEST Scientific Report 2007-2009 Nanotechnology for intracellular delivery and targeting of drugs, nanoreporters  

E-Print Network [OSTI]

attention on the arginine-rich motif derived from the HIV transactivator of transcription protein Tat (residues 47-57 YGRKKRRQRRR of HIV-Tat protein full length). In order to elucidate the entrance pathway of Tat arginin-rich peptides and provides further information on the controversial mechanism of its

Abbondandolo, Alberto

310

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery  

Science Journals Connector (OSTI)

...by charged and polar patches. Figure 7 The human...essential for normal DNA repair, there is an advantage...structure determination pipeline. Proc. Natl Acad...double-strand-break-repair mutant mammalian cells...gene and its role in DNA repair and V(D)J recombination...

2006-01-01T23:59:59.000Z

311

A battle with superbugs : New compounds and targets against drug-resistant pathogens  

E-Print Network [OSTI]

small-scale expression (~10 ml) check on each of the four-deletion mutants was performed using a nickel- resin purification

Haste, Nina M.

2012-01-01T23:59:59.000Z

312

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Key Dates Key Dates Science Undergraduate Laboratory Internships (SULI) SULI Home Eligibility Benefits Participant Obligations How to Apply Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A RSS Feeds FeedbackShare Page At the submission deadline (shown in red) the application system will close, and no materials will be accepted after the submission deadline has passed. The Application System closes at 5:00 PM Eastern Time. SULI Internship Term: Spring 2014 Summer 2014* Fall 2013 On-line Application Opens August 6, 2013 October 18, 2013 May 1, 2013 Applications Due October, 1, 2013 5:00 PM ET January 10, 2014 5:00 PM ET June 12, 2013 5:00 PM ET Offer Notification Period Begins on or around October, 15, 2013 January 20, 2014 June 24, 2013

313

Key Dates | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Key Dates Key Dates Visiting Faculty Program (VFP) VFP Home Eligibility Benefits Participant Obligations How to Apply Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A RSS Feeds FeedbackShare Page At the submission deadline (shown in red) the application system will close, and no materials will be accepted after the submission deadline has passed. The Application System closes at 5:00 PM Eastern Time. VFP Term: Summer 2014 On-line Application Opens October 18, 2013 Applications Due January 10, 2014 5:00 PM ET* Offer Notification Period Begins January 20, 2014 All DOE Offers and Notifications Complete April 1, 2014 *A research proposal co-developed with a DOE laboratory researcher must be electronically submitted by all faculty applicants as part of their

314

U-268: Oracle Database Authentication Protocol Discloses Session Key  

Broader source: Energy.gov (indexed) [DOE]

8: Oracle Database Authentication Protocol Discloses Session 8: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users U-268: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users September 26, 2012 - 6:00am Addthis PROBLEM: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users PLATFORM: Oracle Database 11g Releases 1 and 2 ABSTRACT: A vulnerability was reported in Oracle Database. reference LINKS: Darkreading Threatpost Arstechnica Oracle Security Alerts SecurityTracker Alert ID: 1027558 CVE-2012-3137 IMPACT ASSESSMENT: Medium Discussion: The authentication protocol in Oracle Database 11g 1 and 2 allows remote attackers to obtain the session key and salt for arbitrary users, which leaks information about the cryptographic hash and makes it easier to

315

Energy Secretary Bodman Commends Key Milestone In MOX Program | Department  

Broader source: Energy.gov (indexed) [DOE]

Commends Key Milestone In MOX Program Commends Key Milestone In MOX Program Energy Secretary Bodman Commends Key Milestone In MOX Program April 1, 2005 - 11:28am Addthis WASHINGTON, DC - In response to the Nuclear Regulatory Commission's (NRC) authorization of the construction of a U.S. Mixed-Oxide (MOX) Fuel Fabrication Facility at the Department of Energy's Savannah River Site in South Carolina, Secretary of Energy Samuel W. Bodman today released the following statement: "Issuing the permit for construction of a MOX facility in South Carolina is the crucial next step in the MOX program. It is a key milestone in our efforts to dispose of surplus weapons grade plutonium in the U.S. and Russia," Secretary Bodman said. "We look forward to proceeding with this nonproliferation program that will ultimately eliminate enough

316

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts December 9, 2009 - 12:00am Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Patricia A. Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, Department of Energy Mari Del Carmen Aponte, Ambassador to the Republic of El Salvador, Department of State Donald E. Booth, Ambassador to the Federal Democratic Republic of Ethiopia, Department of State Larry Persily, Federal Coordinator for Alaska Natural Gas Transportation Projects President Obama said, "The depth of experience these individuals bring to their roles will be valuable to my administration as we work to bring about

317

Department of Energy Announces Key Additions to Public Affairs Staff |  

Broader source: Energy.gov (indexed) [DOE]

Announces Key Additions to Public Affairs Announces Key Additions to Public Affairs Staff Department of Energy Announces Key Additions to Public Affairs Staff February 26, 2009 - 12:00am Addthis WASHINGTON, DC - Today, the Department of Energy announced key staff additions to the Office Public Affairs: Dan Leistikow, Director of Public Affairs; Tom Reynolds, Deputy Director of Public Affairs; Stephanie Mueller, Press Secretary; and Tiffany Edwards, Deputy Press Secretary. "I am pleased to have these talented individuals join the Department of Energy", said Secretary Steven Chu. "Having worked on President Obama's presidential campaign Dan, Tom, Stephanie and Tiffany bring knowledge about the President's commitment to end our addiction to foreign oil, invest in alternative and renewable energy, address the global climate crisis and

318

U-268: Oracle Database Authentication Protocol Discloses Session Key  

Broader source: Energy.gov (indexed) [DOE]

8: Oracle Database Authentication Protocol Discloses Session 8: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users U-268: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users September 26, 2012 - 6:00am Addthis PROBLEM: Oracle Database Authentication Protocol Discloses Session Key Information to Remote Users PLATFORM: Oracle Database 11g Releases 1 and 2 ABSTRACT: A vulnerability was reported in Oracle Database. reference LINKS: Darkreading Threatpost Arstechnica Oracle Security Alerts SecurityTracker Alert ID: 1027558 CVE-2012-3137 IMPACT ASSESSMENT: Medium Discussion: The authentication protocol in Oracle Database 11g 1 and 2 allows remote attackers to obtain the session key and salt for arbitrary users, which leaks information about the cryptographic hash and makes it easier to

319

Table A4. Residential sector key indicators and consumption  

Gasoline and Diesel Fuel Update (EIA)

3 3 U.S. Energy Information Administration | Annual Energy Outlook 2013 Reference case Table A4. Residential sector key indicators and consumption (quadrillion Btu per year, unless otherwise noted) Energy Information Administration / Annual Energy Outlook 2013 Table A4. Residential sector key indicators and consumption (quadrillion Btu per year, unless otherwise noted) Key indicators and consumption Reference case Annual growth 2011-2040 (percent) 2010 2011 2020 2025 2030 2035 2040 Key indicators Households (millions) Single-family ....................................................... 82.85 83.56 91.25 95.37 99.34 103.03 106.77 0.8% Multifamily ........................................................... 25.78 26.07 29.82 32.05 34.54 37.05 39.53 1.4%

320

DOE Announces More Key Administration Posts | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

More Key Administration Posts More Key Administration Posts DOE Announces More Key Administration Posts March 27, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Ray Mabus, Secretary of the Navy, Department of Defense; Donald Remy, General Counsel of the Army, Department of Defense; J. Randolph Babbitt, Administrator, Federal Aviation Administration; Jose D. Riojas, Assistant Secretary for Operations, Security and Preparedness, Department of Veterans Affairs; John Trasviña, Assistant Secretary for Fair Housing and Equal Opportunity, Department of Housing and Urban Development; Lawrence E. Strickling, Assistant Secretary for Communications and Information, Department of Commerce; and Cathy Zoi, Assistant Secretary for Energy Efficiency and

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Key Factors in Displacement Ventilation Systems for Better IAQ  

E-Print Network [OSTI]

ICEBO2006, Shenzhen, China Maximize Comfort: Temperature, Humidity and IAQ Vol.I-7-2 Key Factors in Displacement Ventilation Systems for Better IAQ1 Xiaotong Wang Junjun Chen Yike Li Zhiwei Wang Associate Professor...

Wang, X.; Chen, J.; Li, Y.; Wang, Z.

2006-01-01T23:59:59.000Z

322

Molecular Pathology in Epidemiologic Studies: A Primer on Key Considerations  

Science Journals Connector (OSTI)

...treatment responses. In this mini review, we highlight specific...specific challenges. In this mini review, we discuss key principles...sentinel cores outside the main grid facilitate orientation. Use...treatment responses. In this mini review, we highlight specific...

Mark E. Sherman; Will Howatt; Fiona M. Blows; Paul Pharoah; Stephen M. Hewitt; and Montserrat Garcia-Closas

2010-04-01T23:59:59.000Z

323

Reflective cracking of shear keys in multi-beam bridges  

E-Print Network [OSTI]

strength to resist cracking from vehicular loads, but uneven temperature changes and shrinkage strains cause high tensile stresses in the shear key regions and lead to reflective cracking. The analyses showed the highest stresses were often times near...

Sharpe, Graeme Peter

2009-06-02T23:59:59.000Z

324

Reactive Support and Voltage Control Service: Key Issues and Challenges  

E-Print Network [OSTI]

Reactive Support and Voltage Control Service: Key Issues and Challenges George Gross^, Paolo of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, e-mail gross@uiuc.edu ° Dipartimento di Ingegneria

Gross, George

325

President Obama Announces More Key Administration Posts | Department...  

Broader source: Energy.gov (indexed) [DOE]

9, 2010 - 12:00am Addthis THE WHITE HOUSE Office of the Press Secretary WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key...

326

Families First: Keys to Successful Family Functioning Communication  

E-Print Network [OSTI]

Families First: Keys to Successful Family Functioning Communication Rick Peterson, Extension Specialist and Assistant Professor, Department of Human Development, Virginia Tech Stephen Green, Department of Human Development, Virginia Tech www.ext.vt.edu Produced by Communications and Marketing, College

Liskiewicz, Maciej

327

Nano Lect 1 Questions and Keypoints Key Points  

E-Print Network [OSTI]

Nano Lect 1 ­ Questions and Keypoints Key Points 1. What is nano technology: a. Very small technology with device in the 1nm to 100nm lots of useful properties Questions 1. Define nanotechnology. Is an nano

Smy, Tom

328

LEDSGP/Transportation Toolkit/Key Actions | Open Energy Information  

Open Energy Info (EERE)

source source History View New Pages Recent Changes All Special Pages Semantic Search/Querying Get Involved Help Apps Datasets Community Login | Sign Up Search Page Edit History Facebook icon Twitter icon » LEDSGP/Transportation Toolkit/Key Actions < LEDSGP‎ | Transportation Toolkit(Redirected from Transportation Toolkit/Key Actions) Jump to: navigation, search LEDSGP Logo.png Transportation Toolkit Home Tools Training Contacts Key Actions for Low-Emission Development in Transportation Although no single approach or fixed process exists for low emission development strategies (LEDS), the following key actions are necessary steps for implementing LEDS in the transportation sector. Undertaking these actions requires flexibility to adapt to dynamic societal conditions in a

329

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts President Obama Announces More Key Administration Posts June 10, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Joan Evans, Assistant Secretary for Congressional and Legislative Affairs, Department of Veterans Affairs; Warren F. "Pete" Miller, Jr., PhD, Assistant Secretary for Nuclear Energy, Department of Energy; and John R. Norris, Commissioner, Federal Energy Regulatory Commission. President Obama said, "I am grateful that these three impressive individuals will be working with me in these important roles. The commitment of these experienced public servants has made an impression on

330

Key Science and Engineering Indicators: Digest 2012 | Data.gov  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Key Science and Engineering Indicators: Digest 2012 Key Science and Engineering Indicators: Digest 2012 BusinessUSA Data/Tools Apps Challenges Let's Talk BusinessUSA You are here Data.gov » Communities » BusinessUSA » Data Key Science and Engineering Indicators: Digest 2012 Dataset Summary Description This 2012 digest of key S&E indicators is an interactive tool that draws from the National Science Board's (NSB's) Science and Engineering Indicators report. The digest serves to draw attention to important trends and data points from across Indicators and to introduce readers to the data resources available in the report. Tags {science,engineering,indicators,statistics,nsf,nsb,srs,federal,government,education,labor,employment,workforce,research,development,industry,international,global,r&d,technology,patents,"research citations"}

331

DOE Announces More Key Administration Posts | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

More Key Administration Posts More Key Administration Posts DOE Announces More Key Administration Posts March 20, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Dr. Steven E. Koonin, Under Secretary for Science, Department of Energy; David Sandalow, Assistant Secretary for Policy and International Affairs, Department of Energy; Ambassador Johnnie Carson, Assistant Secretary for African Affairs, State Department; Kathy Martinez, Assistant Secretary for Disability Employment Policy (ODEP), Department of Labor; Jonathan S. Adelstein, Administrator for the Rural Utilities Service, United States Department of Agriculture; Timothy W. Manning, Deputy Administrator for National Preparedness, FEMA, Department of Homeland Security; and Priscilla

332

Key Activities in Energy Efficiency | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

About » Key Activities in Energy Efficiency About » Key Activities in Energy Efficiency Key Activities in Energy Efficiency The Building Technologies Office conducts work in three key areas in order to continually develop innovative, cost-effective energy saving solutions: research and development (R&D), market stimulation, and building codes and equipment standards. Working with our partners on these activities results in better products, better new homes, better ways to improve older homes, and better buildings in which to work, shop, and lead our everyday lives. Research and Development Spearhead the development of new, energy efficient technologies. Lead R&D activities that reduce home energy use through Building America. Collaborate with industry to improve the energy efficiency of new

333

Design and evaluation of deer guards for Florida Key Deer  

E-Print Network [OSTI]

Because of increased deer/vehicle collisions involving endangered Florida Key deer (Odocoileus virginianus clavium), the Florida Department of Transportation (FDOT) developed a plan to construct a fence along a portion of US Highway 1 that crosses...

Sebesta, Jason Daryl

2012-06-07T23:59:59.000Z

334

The HERMES Polarized Hydrogen Internal Gas Target  

E-Print Network [OSTI]

internal gas targets. The HERMES hydrogen target is an internal polarized gas target using the storage cell frame on the right. atomic hydrogen beam and focuses it into a storage cell. The storage cellThe HERMES Polarized Hydrogen Internal Gas Target J. Stewart for The HERMES Collaboration

335

Security of quantum key distribution with arbitrary individual imperfections  

SciTech Connect (OSTI)

We consider the security of the Bennett-Brassard 1984 protocol for quantum key distribution, with arbitrary individual imperfections simultaneously in the source and detectors. We provide the secure key generation rate and show that three parameters must be bounded to ensure security; the basis dependence of the source, a detector-blinding parameter, and a detector leakage parameter. The system may otherwise be completely uncharacterized and contain large losses.

Maroey, Oystein; Lydersen, Lars; Skaar, Johannes [Department of Electronics and Telecommunications, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway and University Graduate Center, NO-2027 Kjeller (Norway)

2010-09-15T23:59:59.000Z

336

W-like bound entangled states and secure key distillation  

E-Print Network [OSTI]

We construct multipartite entangled states with underlying W-type structure satisfying positive partial transpose (PPT) condition under any (N-1)|1 partition. Then we show how to distill N-partite secure key form the states using two different methods: direct application of local filtering and novel random key distillation scheme in which we adopt the idea form recent results on entanglement distillation. Open problems and possible implications are also discussed.

Remigiusz Augusiak; Pawel Horodecki

2008-11-21T23:59:59.000Z

337

Multishell inertial confinement fusion target  

DOE Patents [OSTI]

A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reaction accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

1984-01-01T23:59:59.000Z

338

Multishell inertial confinement fusion target  

DOE Patents [OSTI]

A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reactions accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

1987-01-01T23:59:59.000Z

339

A Cryogenic Infrared Calibration Target  

E-Print Network [OSTI]

A compact cryogenic calibration target is presented that has a peak diffuse reflectance, $R \\le 0.003$, from $800-4,800\\,{\\rm cm}^{-1}$ $(12-2\\,\\mu$m). Upon expanding the spectral range under consideration to $400-10,000\\,{\\rm cm}^{-1}$ $(25-1\\,\\mu$m) the observed performance gracefully degrades to $R \\le 0.02$ at the band edges. In the implementation described, a high-thermal-conductivity metallic substrate is textured with a pyramidal tiling and subsequently coated with a thin lossy dielectric coating that enables high absorption and thermal uniformity across the target. The resulting target assembly is lightweight, has a low-geometric profile, and has survived repeated thermal cycling from room temperature to $\\sim4\\,$K. Basic design considerations, governing equations, and test data for realizing the structure described are provided. The optical properties of selected absorptive materials -- Acktar Fractal Black, Aeroglaze Z306, and Stycast 2850 FT epoxy loaded with stainless steel powder -- are character...

Wollack, Edward J; Rinehart, Stephan A

2014-01-01T23:59:59.000Z

340

source_target+_rev11.PDF  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

4-1 - April 15 4-1 - April 15 th , 2000 4. Target System and Support Facility 4.1 Overview The target facility extends from the pre-target primary beam focusing to the end of the decay channel. Technical components include the target, beam absorber, and solenoid magnetic field focusing system. While the ultimate goal is to target approximately 4 MW of proton beam in the target area, smaller values and different target materials (low Z etc.) are considered for the first phase of operation. Chosen initially is a carbon target with incident primary beam power of 1.5 MW. The target is embedded in a high field solenoid magnet of 20 Tesla, and followed by a matching section channel, where the field tapers down to 1.25 T. An iterative design process has been carried out in optimizing Monte

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Comparisons on thin and thick neutron target for low energy proton beam  

SciTech Connect (OSTI)

As the progress on accelerator physics and neutronics, the compact neutron sources driven by low energy and high intensity beam are becoming extensively developed and researched all around the world. The neutron target of an accelerator driven neutron source is one of the key components, and the stability of the neutron target affect the operation and performance of the neutron facility. When a low energy proton is projected to the beryllium target, the main reaction is the inelastic scattering between the proton and extra-nuclear electrons. As the decreasing of proton energy, the rate of elastic scattering between proton and target nucleus begins to increase. When the energy of proton is very low, the pickup charge reaction begins to appear. Focus on the problems brought by high intensity proton beam such as proton implantation, radiation damages, heat deposition and gas production, we performed sufficient numerical simulations for both thin and thick target determined by proton range. The results show that the critical problem for thick target is the proton implantation, causing the forming of bubbles and beryllium flaked in vacuum. The thin target sacrifices a little neutron yield, but avoid the proton stopped in target, and decrease the radiation damage and energy deposition. (authors)

Zhong, B.; Yu, G.; Wang, X.; Wang, K. [Dept. of Engineering Physics, Tsinghua Univ., Beijing 100084 (China)

2012-07-01T23:59:59.000Z

342

Independent Oversight Targeted Review, Sandia National Laboratories -  

Broader source: Energy.gov (indexed) [DOE]

Targeted Review, Sandia National Laboratories Targeted Review, Sandia National Laboratories - November 2013 Independent Oversight Targeted Review, Sandia National Laboratories - November 2013 December 2013 Targeted Review of Activity-Level Implementation of Radiological Controls at Sandia National Laboratories This report documents the results of an independent oversight targeted review of radiological protection program activity-level implementation for Sandia National Laboratories (SNL), Technical Area V facilities. SNL is managed by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, under contract to the Department of Energy (DOE) and is overseen by the National Nuclear Security Administration and its Sandia Field Office. This targeted review was performed at SNL September 23-27,

343

Energy Storage: The Key to a Reliable, Clean Electricity Supply |  

Broader source: Energy.gov (indexed) [DOE]

Storage: The Key to a Reliable, Clean Electricity Supply Storage: The Key to a Reliable, Clean Electricity Supply Energy Storage: The Key to a Reliable, Clean Electricity Supply February 22, 2012 - 4:52pm Addthis Improved energy storage technology offers a number of economic and environmental benefits. Improved energy storage technology offers a number of economic and environmental benefits. Matthew Loveless Matthew Loveless Data Integration Specialist, Office of Public Affairs What does this project do? ARPA-E's GRIDS program is investing in new technologies that make storing energy cheaper and more efficient. Energy storage isn't just for AA batteries any more. Thanks to investments from the Department's Advanced Research Projects Agency-Energy (ARPA-E), energy storage may soon play a bigger part in our electricity

344

Technology Key to Harnessing Natural Gas Potential | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Technology Key to Harnessing Natural Gas Potential Technology Key to Harnessing Natural Gas Potential Technology Key to Harnessing Natural Gas Potential July 18, 2012 - 3:52pm Addthis Deputy Secretary Daniel Poneman tours Proinlosa Energy Corp. in Houston, Texas. Proinlosa is a company in the wind turbine manufacturing supply chain that develops tower parts and has benefitted from the Production Tax Credit (PTC). | Photo courtesy of Keri Fulton. Deputy Secretary Daniel Poneman tours Proinlosa Energy Corp. in Houston, Texas. Proinlosa is a company in the wind turbine manufacturing supply chain that develops tower parts and has benefitted from the Production Tax Credit (PTC). | Photo courtesy of Keri Fulton. Daniel B. Poneman Daniel B. Poneman Deputy Secretary of Energy What does this project do? Builds on President Obama's call for a new era for American energy

345

Sierra Geothermal's Key Find in Southern Nevada | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Sierra Geothermal's Key Find in Southern Nevada Sierra Geothermal's Key Find in Southern Nevada Sierra Geothermal's Key Find in Southern Nevada July 13, 2010 - 5:17pm Addthis Sierra Geothermal discovered temperatures hot enough for large-scale geothermal energy production at one of its wells near Silver Peak, Nev. | Photo courtesy of Sierra Geothermal Sierra Geothermal discovered temperatures hot enough for large-scale geothermal energy production at one of its wells near Silver Peak, Nev. | Photo courtesy of Sierra Geothermal Paul Lester Communications Specialist for the Office of Energy Efficiency and Renewable Energy In May 2010, Sierra Geothermal determined temperature at the bottom of a well drilled at the company's Alum project near Silver Peak, Nev., was hot enough for commercial-sized geothermal energy production - measured as 147

346

Transportation Energy Futures Study: The Key Results and Conclusions  

Open Energy Info (EERE)

Transportation Energy Futures Study: The Key Results and Conclusions Transportation Energy Futures Study: The Key Results and Conclusions Webinar Home > Groups > OpenEI Community Central Graham7781's picture Submitted by Graham7781(1992) Super contributor 1 May, 2013 - 11:38 This webinar will outline the key results and conclusions from EERE's Transportation Energy Futures study, which highlights underexplored opportunities to reduce petroleum use and greenhouse gas emissions from the U.S. transportation sector. There will be time for questions from attendees at the end of the webinar. Principal Deputy Assistant Secretary Mike Carr will introduce the study and provide context on EERE's transportation energy strategy. In his role with EERE, Mike provides leadership direction on cross-cutting activities in EERE's portfolio. In particular, he is using his experience in policy

347

Sierra Geothermal's Key Find in Southern Nevada | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Sierra Geothermal's Key Find in Southern Nevada Sierra Geothermal's Key Find in Southern Nevada Sierra Geothermal's Key Find in Southern Nevada July 13, 2010 - 5:17pm Addthis Sierra Geothermal discovered temperatures hot enough for large-scale geothermal energy production at one of its wells near Silver Peak, Nev. | Photo courtesy of Sierra Geothermal Sierra Geothermal discovered temperatures hot enough for large-scale geothermal energy production at one of its wells near Silver Peak, Nev. | Photo courtesy of Sierra Geothermal Paul Lester Communications Specialist, Office of Energy Efficiency and Renewable Energy In May 2010, Sierra Geothermal determined temperature at the bottom of a well drilled at the company's Alum project near Silver Peak, Nev., was hot enough for commercial-sized geothermal energy production - measured as 147

348

Worldwide Trends in Energy Use and Efficiency: Key Insights from  

Open Energy Info (EERE)

Worldwide Trends in Energy Use and Efficiency: Key Insights from Worldwide Trends in Energy Use and Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Worldwide Trends in Energy Use and Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Focus Area: Power Plant Efficiency Topics: Potentials & Scenarios Website: www.iea.org/papers/2008/indicators_2008.pdf Equivalent URI: cleanenergysolutions.org/content/worldwide-trends-energy-use-and-effic Language: English Policies: "Regulations,Deployment Programs" is not in the list of possible values (Deployment Programs, Financial Incentives, Regulations) for this property.

349

Managing Supply Chain Key for Hawaii Appliance Rebate Program | Department  

Broader source: Energy.gov (indexed) [DOE]

Managing Supply Chain Key for Hawaii Appliance Rebate Program Managing Supply Chain Key for Hawaii Appliance Rebate Program Managing Supply Chain Key for Hawaii Appliance Rebate Program August 24, 2010 - 10:00am Addthis Lindsay Gsell Hawaii's appliance rebate program delivered 4,300 rebates to Hawaiians in just three days. And on just the first day of program, almost 4,000 ENERGY STAR qualified refrigerators were sold. Funded by $1.2 million from the American Recovery and Reinvestment Act, the program delivered a proportionate number of $250 ENERGY STAR refrigerator rebates to six of Hawaii's islands: Oahu, Hawaii, Maui, Kauai, Lanai, and Molokai. "It takes a lot of help from manufacturers, distributors, retailers, hauling company, recyclers, advertisers, printers, new reporters, radio stations and television station to create a success story," said Derrick

350

Managing Supply Chain Key for Hawaii Appliance Rebate Program | Department  

Broader source: Energy.gov (indexed) [DOE]

Managing Supply Chain Key for Hawaii Appliance Rebate Program Managing Supply Chain Key for Hawaii Appliance Rebate Program Managing Supply Chain Key for Hawaii Appliance Rebate Program August 24, 2010 - 10:00am Addthis Lindsay Gsell Hawaii's appliance rebate program delivered 4,300 rebates to Hawaiians in just three days. And on just the first day of program, almost 4,000 ENERGY STAR qualified refrigerators were sold. Funded by $1.2 million from the American Recovery and Reinvestment Act, the program delivered a proportionate number of $250 ENERGY STAR refrigerator rebates to six of Hawaii's islands: Oahu, Hawaii, Maui, Kauai, Lanai, and Molokai. "It takes a lot of help from manufacturers, distributors, retailers, hauling company, recyclers, advertisers, printers, new reporters, radio stations and television station to create a success story," said Derrick

351

Energy Storage: The Key to a Reliable, Clean Electricity Supply |  

Broader source: Energy.gov (indexed) [DOE]

Energy Storage: The Key to a Reliable, Clean Electricity Supply Energy Storage: The Key to a Reliable, Clean Electricity Supply Energy Storage: The Key to a Reliable, Clean Electricity Supply February 22, 2012 - 4:52pm Addthis Improved energy storage technology offers a number of economic and environmental benefits. Improved energy storage technology offers a number of economic and environmental benefits. Matthew Loveless Matthew Loveless Data Integration Specialist, Office of Public Affairs What does this project do? ARPA-E's GRIDS program is investing in new technologies that make storing energy cheaper and more efficient. Energy storage isn't just for AA batteries any more. Thanks to investments from the Department's Advanced Research Projects Agency-Energy (ARPA-E), energy storage may soon play a bigger part in our electricity

352

Single, Key Gene Discovery Could Streamline Production of Biofuels |  

Broader source: Energy.gov (indexed) [DOE]

Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels August 11, 2011 - 3:51pm Addthis WASHINGTON, DC -- A team of researchers at the Department of Energy's BioEnergy Science Center (BESC) have pinpointed the exact, single gene that controls ethanol production capacity in a microorganism. This discovery could be the missing link in developing biomass crops that produce higher concentrations of ethanol at lower costs. "The Department of Energy relies on the scientific discoveries of its labs and research centers to improve the production of clean energy sources," said Energy Secretary Steven Chu. "This discovery is an important step in developing biomass crops that could increase yield of

353

Building MRV Standards and Capacity in Key Countries | Open Energy  

Open Energy Info (EERE)

MRV Standards and Capacity in Key Countries MRV Standards and Capacity in Key Countries Jump to: navigation, search Name Building MRV Standards and Capacity in Key Countries Agency/Company /Organization World Resources Institute (WRI) Sector Climate Focus Area Renewable Energy Topics Implementation Website http://www.wri.org/topics/mrv Program Start 2011 Program End 2014 Country Brazil, Colombia, Ethiopia, India, South Africa, Thailand South America, South America, Eastern Africa, Southern Asia, Southern Africa, South-Eastern Asia References World Resources Institute (WRI)[1] Program Overview Developing countries will be required to measure, report, and verify (MRV) mitigation actions according to international guidelines, but few have the capacity to do so. The goal of this project is to build the capacity of a

354

Florida Keys El Coop Assn, Inc | Open Energy Information  

Open Energy Info (EERE)

Keys El Coop Assn, Inc Keys El Coop Assn, Inc Jump to: navigation, search Name Florida Keys El Coop Assn, Inc Place Florida Utility Id 6443 Utility Location Yes Ownership C NERC Location FRCC NERC FRCC Yes Operates Generating Plant Yes Activity Generation Yes Activity Transmission Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Rate Code 1 - Residential Service Residential Rate Code 2 - Commercial Service (General Service Non-Demand) Commercial Rate Code 3 - Commercial Service (General Service Demand) Commercial Average Rates Residential: $0.1210/kWh Commercial: $0.1220/kWh Industrial: $0.1140/kWh

355

Turn Your Key, Be Idle Free | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Turn Your Key, Be Idle Free Turn Your Key, Be Idle Free Turn Your Key, Be Idle Free April 13, 2010 - 7:30am Addthis Shannon Brescher Shea Communications Manager, Clean Cities Program What activity wastes gasoline, costs money, produces pollutants, and yet doesn't get you anywhere? Idling! And yet, every year, Americans waste 3 billion gallons of fuel by idling their vehicles. Idling is running a vehicle any time that it's not moving. In this condition, the car's fuel economy is exactly zero miles per gallon. Although many people think that restarting the engine too often will wear out the starter, that idea is just an "old husband's tale." In fact, idling places unnecessary wear-and-tear on the engine, and many manufacturers discourage it. Although drivers can't avoid some amount of idling, such as being stuck in

356

Ariz. Rooftops Key to Unlocking the Potential of Distributed Solar |  

Broader source: Energy.gov (indexed) [DOE]

Ariz. Rooftops Key to Unlocking the Potential of Distributed Solar Ariz. Rooftops Key to Unlocking the Potential of Distributed Solar Ariz. Rooftops Key to Unlocking the Potential of Distributed Solar July 12, 2010 - 3:51pm Addthis APS will install solar photovoltaic panels like these in Castro Valley, Calif. for a pilot project studying distributed energy in Flagstaff, Ariz. | Photo courtesy of APS APS will install solar photovoltaic panels like these in Castro Valley, Calif. for a pilot project studying distributed energy in Flagstaff, Ariz. | Photo courtesy of APS Nestled in the mountains of northern Arizona and just 75 miles from Grand Canyon National Park, the city of Flagstaff, Ariz. is an ideal city for the Arizona Public Service (APS) to pilot a high concentration of solar photovoltaic energy systems. "Flagstaff is unique electrically," says Eran Mahrer, Director of Renewable

357

Field Test of Measurement-Device-Independent Quantum Key Distribution  

E-Print Network [OSTI]

A main type of obstacles of practical applications of quantum key distribution (QKD) network is various attacks on detection. Measurement-device-independent QKD (MDIQKD) protocol is immune to all these attacks and thus a strong candidate for network security. Recently, several proof-of-principle demonstrations of MDIQKD have been performed. Although novel, those experiments are implemented in the laboratory with secure key rates less than 0.1 bps. Besides, they need manual calibration frequently to maintain the system performance. These aspects render these demonstrations far from practicability. Thus, justification is extremely crucial for practical deployment into the field environment. Here, by developing an automatic feedback MDIQKD system operated at a high clock rate, we perform a field test via deployed fiber network of 30 km total length, achieving a 16.9 bps secure key rate. The result lays the foundation for a global quantum network which can shield from all the detection-side attacks.

Yan-Lin Tang; Hua-Lei Yin; Si-Jing Chen; Yang Liu; Wei-Jun Zhang; Xiao Jiang; Lu Zhang; Jian Wang; Li-Xing You; Jian-Yu Guan; Dong-Xu Yang; Zhen Wang; Hao Liang; Zhen Zhang; Nan Zhou; Xiongfeng Ma; Teng-Yun Chen; Qiang Zhang; Jian-Wei Pan

2014-08-11T23:59:59.000Z

358

Quantum-Secure Authentication with a Classical Key  

E-Print Network [OSTI]

Authentication provides the trust people need to engage in transactions. The advent of physical keys that are impossible to copy promises to revolutionize this field. Up to now, such keys have been verified by classical challenge-response protocols. Such protocols are in general susceptible to emulation attacks. Here we demonstrate Quantum-Secure Authentication ("QSA") of an unclonable classical physical key in a way that is inherently secure by virtue of quantum-physical principles. Our quantum-secure authentication operates in the limit of a large number of channels, represented by the more than thousand degrees of freedom of an optical wavefront shaped with a spatial light modulator. This allows us to reach quantum security with weak coherent pulses of light containing dozens of photons, too few for an adversary to determine their complex spatial shapes, thereby rigorously preventing emulation.

Sebastianus A. Goorden; Marcel Horstmann; Allard P. Mosk; Boris Škori?; Pepijn W. H. Pinkse

2014-06-03T23:59:59.000Z

359

Security Proof of a Semi-Quantum Key Distribution Protocol  

E-Print Network [OSTI]

Semi-quantum key distribution protocols are designed to allow two users to establish a secure secret key when one of the two users is limited to performing certain "classical" operations. There have been several such protocols developed recently, however, due to their reliance on a two-way quantum communication channel (and thus, the attacker's opportunity to interact with the qubit twice), their security analysis is difficult and little is known concerning how secure they are compared to their fully quantum counterparts. In this paper we prove the unconditional security of a particular semi-quantum protocol. We derive an expression for the key rate of this protocol, in the asymptotic scenario, as a function of the quantum channel's noise. Finally, we will show that this semi-quantum protocol can tolerate a maximal noise level comparable to certain fully quantum protocols.

Walter O. Krawec

2014-11-30T23:59:59.000Z

360

Property:Specializations, Capabilities, and Key Facility Attributes Not  

Open Energy Info (EERE)

Property Property Edit with form History Facebook icon Twitter icon » Property:Specializations, Capabilities, and Key Facility Attributes Not Covered Elsewhere Jump to: navigation, search Property Name Specializations, Capabilities, and Key Facility Attributes Not Covered Elsewhere Property Type Text Pages using the property "Specializations, Capabilities, and Key Facility Attributes Not Covered Elsewhere" Showing 25 pages using this property. 1 11-ft Wave Flume Facility + Glass window 6 6-ft Wave Flume Facility + Glass window A Alden Large Flume + This is a recirculating flume facility, so a constant velocity can be maintained indefinitely. This allows collection of a much greater amount of data than possible in tow tanks. Alden's biologists are highly experienced in assessing the impacts of generation devices on fish and the facilities allow for accurate testing with fish in a highly controlled environment.

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Special Presentation: Key Findings from the Barrier Immune Radio  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Special Presentation: Key Findings from the Barrier Immune Radio Special Presentation: Key Findings from the Barrier Immune Radio Communications Project Speaker(s): Francis Rubinstein Girish Ghatikar Peter Haugen Date: November 29, 2007 - 12:00pm Location: 90-3122 The Barrier Immune Radio Communications (BIRC) Project was established in January 2007 by the Demand Response Emerging Technologies Program (DRETD) to identify radio frequency technologies that could enable the widespread deployment of Demand Response strategies in buildings. Researchers from Lawrence Berkeley National Laboratory and Lawrence Livermore National Laboratory will present the key findings from this project in a one-hour presentation. Researchers found that several of the RF technologies tested at LBNL's Molecular Foundry building were able to provide sufficiently

362

Small Businesses Key in Hydropower Tech Advancement | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Businesses Key in Hydropower Tech Advancement Businesses Key in Hydropower Tech Advancement Small Businesses Key in Hydropower Tech Advancement September 6, 2011 - 2:59pm Addthis Earlier today, the Department of Energy and the Department of Interior announced nearly $17 million in funding over the next three years to advance hydropower technology. The funding announced today will go to sixteen innovative projects around the country, including sustainable small hydro projects, like the ones from Hydro Green Energy, a small business that handles hydroelectric power generation and power and communication line construction. The company, which has eight employees currently, has been awarded funding for two projects. Near Space Systems, a Colorado Springs-based company, is a service-disabled veteran-owned business with a manufacturing focus that's

363

Cancer theranostics: the rise of targeted magnetic nanoparticles  

Science Journals Connector (OSTI)

Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has increased considerably over the past two decades. This excitement has been driven in large part by the success of \\{MNPs\\} as contrast agents in magnetic resonance imaging. The recent investigative trend with respect to cancer has continued down a diagnostic path, but has also turned toward concurrent therapy, giving rise to the distinction of \\{MNPs\\} as potential “theranostics”. Here we review both the key technical principles of \\{MNPs\\} and ongoing advancement toward a cancer theranostic MNP. Recent progress in diagnostics, hyperthermia treatments, and drug delivery are all considered. We conclude by identifying current barriers to clinical translation of \\{MNPs\\} and offer considerations for their future development.

Adam J. Cole; Victor C. Yang; Allan E. David

2011-01-01T23:59:59.000Z

364

Neuroimaging for drug addiction and related behaviors  

SciTech Connect (OSTI)

In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

2011-10-01T23:59:59.000Z

365

Energy Critical Infrastructure and Key Resources Sector-Specific  

Broader source: Energy.gov (indexed) [DOE]

Energy Energy Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) May 2007 Department of Energy Energy Sector Government Coordinating Council Letter of Support i ii Energy Sector-Specific Plan (Redacted) Energy Sector Coordinating Councils Letter of Concurrence The National Infrastructure Protection Plan (NIPP) provides the unifying structure for the integration of federal critical infrastructures and key resources (CI/KR) protection efforts into a single national program. The NIPP includes an overall framework integrating federal programs and activities that are currently underway in the various sectors, as well as new and developing CI/KR protection efforts. The Energy

366

LEDSGP/Transportation Toolkit/Key Actions | Open Energy Information  

Open Energy Info (EERE)

Actions Actions < LEDSGP‎ | Transportation Toolkit Jump to: navigation, search LEDSGP Logo.png Transportation Toolkit Home Tools Training Contacts Key Actions for Low-Emission Development in Transportation Although no single approach or fixed process exists for low-emission development strategies (LEDS), the following key actions are necessary steps for implementing LEDS in the transportation sector. Undertaking these actions requires flexibility to adapt to dynamic societal conditions in a way that complements existing climate and development goals in other sectors. Planners, researchers, and decision-makers should customize this LEDS implementation framework for the specific conditions of their transport sector, choosing from relevant resources to achieve a comprehensive action

367

Quantum key distribution with passive decoy state selection  

Science Journals Connector (OSTI)

We propose a quantum key distribution scheme which closely matches the performance of a perfect single photon source. It nearly attains the physical upper bound in terms of key generation rate and maximally achievable distance. Our scheme relies on a practical setup based on a parametric downconversion source and present day, nonideal photon-number detection. Arbitrary experimental imperfections which lead to bit errors are included. We select decoy states by classical postprocessing. This allows one to improve the effective signal statistics and achievable distance.

Wolfgang Mauerer and Christine Silberhorn

2007-05-31T23:59:59.000Z

368

GERMAN REFORMS AFFECT DRUG R&D  

Science Journals Connector (OSTI)

Under the national health care system, insurers pay for consumers' prescription drugs and get a 6% rebate from manufacturers to help contain costs; the remainder ... ...

PATRICIA SHORT

2003-09-01T23:59:59.000Z

369

Was Sherlock Holmes a Drug Addict?  

Science Journals Connector (OSTI)

... AN occasional correspondent contributes an amusing article to The Lancet of December 26 entitled “Was Sherlock Holmes a Drug Addict?”, as his friend Dr. Watson ...

1937-01-02T23:59:59.000Z

370

OMEGA Laser System completes 20,000th target shot | National Nuclear  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

OMEGA Laser System completes 20,000th target shot | National Nuclear OMEGA Laser System completes 20,000th target shot | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > OMEGA Laser System completes 20,000th target shot OMEGA Laser System completes 20,000th target shot Posted By Office of Public Affairs OMEGA Laser The OMEGA Laser System, a key asset for NNSA's stockpile

371

Spanish energy roadmap to 2020: Socioeconomic implications of renewable targets  

Science Journals Connector (OSTI)

The European Union has established challenging targets for the share of renewable energies to be achieved by 2020; for Spain, 20% of the final energy consumption must be from renewable sources at such time. The aim of this paper is the analysis of the consequences for the electricity sector (in terms of excess cost of electricity, investment requirements, land occupation, CO2 emissions and overcapacity of conventional power) of several possibilities to comply with the desired targets. Scenarios are created from different hypotheses for energy demand, biofuel share in final energy in transport, contribution of renewables for heating and cooling, renewable electricity generation (generation mix, deployment rate, learning curves, land availability) and conventional power generation (lifetime of current installations, committed deployment, fossil fuel costs and CO2 emissions cost). A key input in the estimations presented is the technical potential and the cost of electricity from renewable sources, which have been estimated in previous, detailed studies by the present authors using a methodology based on a GIS (Geographical Information System) and high resolution meteorological data. Depending on the scenario, the attainment of the targets will lead to an increase in the cost of electricity from 19% to 37% with respect to 2007.

Antonio Gómez; Javier Zubizarreta; César Dopazo; Norberto Fueyo

2011-01-01T23:59:59.000Z

372

Review of the Renewable Energy Target  

E-Print Network [OSTI]

Review of the Renewable Energy Target Response to Expert Panel's Call for Submissions Paper #12;NSW Government Submission to the Review of the Renewable Energy Target, May 2014 2/20 Contents EXECUTIVE SUMMARY........................................................................................................................... 3 RENEWABLE ENERGY IN NSW

Peters, Richard

373

Nanoparticles for targeting the infarcted heart  

E-Print Network [OSTI]

We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in ...

Dvir, Tal

374

1/17/12 The Risks Of "Key Recovery," "Key Escrow," And "Trusted Third-Party" Encryption | 1998 1/24www.cdt.org/crypto/risks98/  

E-Print Network [OSTI]

and substantively unchallenged: The deployment of key recovery systems designed to facilitate surreptitious

Goldwasser, Shafi

375

FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS  

E-Print Network [OSTI]

Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ...

Flynn, Colleen A.

2011-12-31T23:59:59.000Z

376

Mexico’s “ley de narcomenudeo” drug policy reform and the international drug control regime  

Science Journals Connector (OSTI)

It has been over half a century since the landmark Single Convention on Narcotic Drugs was adopted, for the first time unifying international drug policy under a single treaty aimed at limiting use, manufacture, ...

Tim K Mackey; Daniel Werb; Leo Beletsky; Gudelia Rangel…

2014-11-01T23:59:59.000Z

377

Table II: Technical Targets for Membranes: Automotive  

Broader source: Energy.gov [DOE]

Technical targets for fuel cell membranes in automotive applications defined by the High Temperature Working Group (February 2003).

378

Table IV: Technical Targets for Membranes: Stationary  

Broader source: Energy.gov [DOE]

"Technical targets for fuel cell membranes in stationary applications defined by the High Temperature Working Group (February 2003). "

379

KeyTex Energy LLC | Open Energy Information  

Open Energy Info (EERE)

KeyTex Energy LLC KeyTex Energy LLC Jump to: navigation, search Name KeyTex Energy LLC Place Greensburg, Pennsylvania Zip 15601 Product KeyTex Energy is a full service energy and consulting company, helping businesses implement both wholesale and retail strategies to control and reduce energy costs as well as manage the risks and complexities associated with the energy markets. Coordinates 40.299245°, -79.543159° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.299245,"lon":-79.543159,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

380

Putting cancer in focusPathologists key to picking the  

E-Print Network [OSTI]

Putting cancer in focusPathologists key to picking the right path to a cure momentum IN THIS ISSUE without cancer. #12;EDITOR Heather Newman DESIGN Diana Duren DIRECTOR OF PUBLICATIONS Wayne Wood ASSOCIATE / Photo Researchers, Inc. EDITORIAL OFFICE Vanderbilt-Ingram Cancer Center 691 Preston Building Nashville

Eichman, Brandt F.

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Key words: STREAMLINE, yeast, scale up, automation, sanitization.  

E-Print Network [OSTI]

adsorption by defining a realistic process example at small scale and taking it all the way up to a fullyKey words: STREAMLINE, yeast, scale up, automation, sanitization. Abstract This application note was evaluated by performing a sanitization study in which the column and system were challenged with culture

Lebendiker, Mario

382

The Seven Keys to Success in Energy Management and Conservation  

E-Print Network [OSTI]

This paper is a summary of the seven key elements of the Deere & Company Energy Management and Conservation Program. These elements have been found to be essential for the ultimate success of any company-wide energy management program. The process...

Darby, D. F.

1984-01-01T23:59:59.000Z

383

SETTING INITIAL SECRET KEYS IN A MOBILE AD HOC NETWORK  

E-Print Network [OSTI]

SETTING INITIAL SECRET KEYS IN A MOBILE AD HOC NETWORK Murat Cihan1 and C¸etin Kaya Ko¸c2,3 1 I@eecs.oregonstate.edu Abstract. Mobile ad hoc networks require specialized authentication protocols due to the mobility of users and lack of always-available trusted servers. There are a variety of mobile ad hoc authentication protocols

384

Global warming triggers the loss of a key Arctic refugium  

Science Journals Connector (OSTI)

...research-article Research articles 1001 69 60 Global warming triggers the loss of a key Arctic...change that is being driven by global warming. In stark contrast to the amplified...planet's last Arctic refugia from global warming, largely because of the moderating...

2013-01-01T23:59:59.000Z

385

Key Title Marine Ecology www.wiley.com  

E-Print Network [OSTI]

biodiversity Chapter 11. Environmental forcing and Southern Ocean marine predator populations: effects in marine ectotherms: an integrative view Chapter 14. Evolution and biodiversity of Antarctic organismsKey Title Marine Ecology www.wiley.com Antarctic Ecosystems: An Extreme Environment in a Changing

Wall, Diana

386

Cedar Key Aquaculture Workshop Sulfide Concentrations in Sediments  

E-Print Network [OSTI]

Cedar Key Aquaculture Workshop Sulfide Concentrations in Sediments and Water: Influence on Hard;ObjectivesObjectives Examine sediment sulfide levels in the SuwanneeExamine sediment sulfide levels of sulfide on hard clam survivalsurvival #12;MethodsMethods SedimentSediment porewaterporewater samples

Florida, University of

387

Securely Managing Cryptographic Keys used within a Cloud Environment  

E-Print Network [OSTI]

to rapidly develop/host cloud applications Infrastructure as a Service (Iaas) - Networked access to processing power, storage Cloud Deployment Models Public Cloud Private Cloud Community Cloud Hybrid administers the Cloud Infrastructure? Who has access to my data? My activity history? Key Management Where

388

TICKS: KEY TO GENERA IN UNITED STATES Harry D. Pratt  

E-Print Network [OSTI]

·38 TICKS: KEY TO GENERA IN UNITED STATES Harry D. Pratt I Capitulum inferior; scutum absent. without definite sutural line. anus, indistinct, or absent. j ~ I lated .... ~ :. / ORNITHODOROS I ment Mouthparts much longer than ..~".'LJv--_, .0",,,,L } }_..., ---'~':r,.-.__.{ Mouthparts as long as basis

389

Cold Boot Key Recovery by Solving Polynomial Systems with Noise  

E-Print Network [OSTI]

Cold Boot Key Recovery by Solving Polynomial Systems with Noise Martin Albrecht and Carlos Cid 1 proposed in [9]; the technique was called Cold Boot attacks. When considering block ciphers Cold Boot attacks, was proposed in [9] and also provided an insight into the strength of a particular

Sheldon, Nathan D.

390

Essentials of Energy Key concepts for the day  

E-Print Network [OSTI]

Essentials of Energy 4/14/05 Key concepts for the day Markets monopoly Substitution volatility Energy intensity Levelized costs externalities I. Market essentials Are there working energy markets: how to manage short term markets in order to get the benefits of long term market #12;Energy

391

news and views A key issue for hydrogen storage materi-  

E-Print Network [OSTI]

news and views A key issue for hydrogen storage materi- als is that the hydrogenation and dehydro be possible to discover stable hydrogen hydrates with higher storage Hydrogen Posture Plan www.eere.energy.gov/hydrogenandfuelcells/pdfs/ hydrogen_posture_plan.pdf 7. Kuhs, W

Palumbi, Stephen

392

BERNAL and RESTREPO Key issues for decentralization in municipal  

E-Print Network [OSTI]

BERNAL and RESTREPO Key issues for decentralization in municipal wastewater treatment Diana Paola, the inadequate management and disposal of wastewater and the implementation of sophisticated treatment systems is the decentralisation in wastewater treatment. In this article, it is proposed an overview of the state of the art

Boyer, Edmond

393

OFFICE OF SPONSORED PROGRAMS KEY RESOURCE INFORMATION Official School Name  

E-Print Network [OSTI]

Point on Hudson, Hoboken, NJ 07030-5991 Type of Business: Corporation, Institution of Higher Education Higher Education Student Assistance Authority Vendor Number 22148735400 Human Subjects IRB No's: #12OFFICE OF SPONSORED PROGRAMS KEY RESOURCE INFORMATION Official School Name Trustees of Stevens

Yang, Eui-Hyeok

394

Using Key Performance Indicators to Manage Energy Costs  

E-Print Network [OSTI]

-effective to collect much more data than ever before, many energy managers find themselves drowning in the volume of data generated. Business information systems faced a similar challenge a decade ago, and it is now common practice to use Key Performance Indicators...

Van Gorp, J. C.

2005-01-01T23:59:59.000Z

395

Extracting Key Factors to Design Applications in Ambient Intelligence Environment  

Science Journals Connector (OSTI)

In an ambient intelligence environment, the design of applications influences the users behavior heavily. The purpose of this paper is to provide key factors considered necessary in developing those applications. We developed four applications applied ... Keywords: ambient feedback, persuasive technology, behavior modification, emotional engagement

Hiroaki Kimura; Tatsuo Nakajima

2008-12-01T23:59:59.000Z

396

Architecture of the Secoqc Quantum Key Distribution network  

E-Print Network [OSTI]

The European projet Secoqc (Secure Communication based on Quantum Cryptography) aims at developing a global network for unconditionally secure key distribution. This paper specifies the requirements and presents the principles guiding the design of this network, and relevant to its architecture and protocols.

Mehrdad Dianati; Romain Alleaume

2006-10-25T23:59:59.000Z

397

Gender: Male Address: The State Key Laboratory of Fluid Power  

E-Print Network [OSTI]

of this simulation system at the first two years. My works focused on the design of power conversion and mechanical, Canjun Yang, Dejun Li, Bo Jin, Ying Chen. Study on 10kVDC powered junction box for cabled oceanYanHu Chen Gender: Male Address: The State Key Laboratory of Fluid Power Transmission and Control

Frandsen, Jannette B.

398

Development of granular target for CADS  

E-Print Network [OSTI]

Subcritical core/blanket #12;· Solid target options, which consist of a solid material in the form of rods 5L/s Width of Lacuna 7cm #12;CW-316LSS The free surface in windowless target Water loop test-Parallel CFD (GPU) for Beam-Target-Coupled 15360 cores Test by the electron beam coupled with water Annular

McDonald, Kirk

399

PLUTONIUM-238 PRODUCTION TARGET DESIGN STUDIES  

SciTech Connect (OSTI)

A new supply chain is planned for plutonium-238 using existing reactors at the Oak Ridge National Laboratory (ORNL) and Idaho National Laboratory (INL) and existing chemical recovery facilities at ORNL. Validation and testing activities for new irradiation target designs have been conducted in three phases over a 2 year period to provide data for scale-up to production. Target design, qualification, target fabrication, and irradiation of fully-loaded targets have been accomplished. Data from post-irradiation examination (PIE) supports safety analysis and irradiation of future target designs.

Hurt, Christopher J [ORNL; Wham, Robert M [ORNL; Hobbs, Randall W [ORNL; Owens, R Steven [ORNL; Chandler, David [ORNL; Freels, James D [ORNL; Maldonado, G Ivan [ORNL

2014-01-01T23:59:59.000Z

400

The World of Youthful Drug Use  

E-Print Network [OSTI]

they meet the fact that the use of drugs is illegal and exposes them to arrest and criminal prosecution. It was obvious that such kinds of information could be secured: only from the youths who were themselves in the drug using world. We could not rely on a...

Blumer, Herbert; Sutter, Alan; Smith, Roger; Ahmed, Samir

2000-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Finite-key-size security of the Phoenix-Barnett-Chefles 2000 quantum-key-distribution protocol  

Science Journals Connector (OSTI)

The postselection technique was introduced by Christandl, König, and Renner [Phys. Rev. Lett. 102, 020504 (2009)] in order to simplify the security of quantum-key-distribution schemes. Here, we present how it can be applied to study the security of the Phoenix-Barnett-Chefles 2000 trine-state protocol, a symmetric version of the Bennett 1992 protocol.

Mhlambululi Mafu, Kevin Garapo, and Francesco Petruccione

2014-09-08T23:59:59.000Z

402

Ignition of deuterium-tritium fuel targets  

DOE Patents [OSTI]

Disclosed is a method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom. 5 figures.

Musinski, D.L.; Mruzek, M.T.

1991-08-27T23:59:59.000Z

403

Thin-thick hydrogen target for nuclear physics  

SciTech Connect (OSTI)

In spectroscopic studies of unstable nuclei, hydrogen targets are of key importance. The CHyMENE Project aims to provide to the nuclear physics community a thin and pure solid windowless hydrogen or deuterium target. CHyMENE project must respond to this request for the production of solid Hydrogen. The solid hydrogen target is produced in a continuous flow (1 cm/s) by an extrusion technique (developed with the PELIN laboratory) in a vacuum chamber. The shape of the target is determined by the design of the nozzle at the extrusion process. For the purpose, the choice is a rectangular shape with a width of 10 mm and a thickness in the range of 30-50 microns necessary for the physics objectives. The cryostat is equipped with a GM Cryocooler with sufficient power for the solidification of the hydrogen in the lower portion of the extruder. In the higher part of the cryostat, the hydrogen gas is first liquefied and partially solidified. It is then compressed at 100 bars in the cooled extruder before expulsion of the film through the nozzle at the center of the reaction vacuum chamber. After the previous step, the solid hydrogen ribbon falls by gravity into a dedicated chamber where it sublimes and the gas is pumped and evacuated in a exhaust line. This paper deals with the design of the cryostat with its equipment, with the sizing of the thermal bridge (Aluminum and copper), with the results regarding the contact resistance as well as with the vacuum computations of the reaction and recovery hydrogen gas chambers.

Gheller, J.-M.; Juster, F.-P.; Authelet, G. [CEA Saclay, Irfu/SACM, F-91191 Gif-Sur-Yvette cedex (France); Vinyar, I. [PELIN Limited Liability Company 27 A, Gzhatskaya Str, office 103 St. Petersbourg 195220 (Russian Federation); Relland, J. [CEA Saclay, Irfu/SIS, F-91191 Gif-Sur-Yvette cedex (France); Commeaux, C. [Institut de Physique Nucléaire, campus Universitaire-Bat 103, 91406 Orsay cedex (France)

2014-01-29T23:59:59.000Z

404

JGI - 2009 Genome Sequencing Targets  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

July 2, 2008 July 2, 2008 Pine Tree, Boat-Boring Bivalve "Bugs", Duck Weed, Oil-Producing Microalgae, Stinkbird Gut, 40 Others Top DOE Joint Genome Institute 2009 Genome Sequencing Targets WALNUT CREEK, CA-In the continuing effort to tap the vast, unexplored reaches of the earth's microbial and plant domains for bioenergy and environmental applications, the DOE Joint Genome Institute (DOE JGI) has announced its latest portfolio of DNA sequencing projects that it will undertake in the coming year. The 44 projects, culled from nearly 150 proposals received through the Community Sequencing Program (CSP), represent over 60 billion nucleotides of data to be generated through this biodiversity sampling campaign-roughly the equivalent of 20 human genomes. "The scientific and technological advances enabled by the information

405

Therapeutic target for protozoal diseases  

DOE Patents [OSTI]

A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

2008-10-21T23:59:59.000Z

406

Terahertz-based target typing.  

SciTech Connect (OSTI)

The purpose of this work was to create a THz component set and understanding to aid in the rapid analysis of transient events. This includes the development of fast, tunable, THz detectors, along with filter components for use with standard detectors and accompanying models to simulate detonation signatures. The signature effort was crucial in order to know the spectral range to target for detection. Our approach for frequency agile detection was to utilize plasmons in the channel of a specially designed field-effect transistor called the grating-gate detector. Grating-gate detectors exhibit narrow-linewidth, broad spectral tunability through application of a gate bias, and no angular dependence in their photoresponse. As such, if suitable sensitivity can be attained, they are viable candidates for Terahertz multi-spectral focal plane arrays.

Lyo, Sungkwun Kenneth; Wanke, Michael Clement; Reno, John Louis; Shaner, Eric Arthur; Grine, Albert D.; Barrick, Todd A.

2008-09-01T23:59:59.000Z

407

Experimental Target Injection and Tracking System  

SciTech Connect (OSTI)

Targets must be injected into an IFE power plant with an accuracy of and plusmn; 5 mm at a rate of approximately 5 to 10 each second. Targets must be tracked very accurately to allow driver beams to be aligned with defined points on the targets with accuracy {+-}200{mu}m for indirect drive and {+-}20{mu}m for direct drive. An experimental target injection and tracking system has been designed and is being constructed at General Atomics to investigate injection and tracking of both direct drive and indirect drive targets. The design is modular to allow testing of alternate target acceleration and tracking methods. The injector system will be used as a tool for testing the survivability of various target designs and provide feed back to the target designers. This 30 m long system will be the centerpiece of a Facility for developing IFE target fabrication and injection technologies. A high-speed high-flow gas valve (designed and built by Oak Ridge National Laboratory) will provide helium propellant gas to the targets. To avoid target damage from excessive acceleration, an 8 m gun barrel is being built to achieve 400 m/s target speed while not exceeding 10,000 m/s{sup 2} acceleration. Direct-drive targets are protected in the barrel by sabots that are spring loaded to separate into two halves after acceleration. A sabot deflector directs the sabot halves away from the target injection path. Gas expansion chambers and orifices, keep propellant gas out of the target-tracking region. Targets will be optically tracked with laser beams and line scan cameras. High-speed computations will calculate target position in less than 2 ms based on the output from the line-scan cameras. Target position and arrival time to a plane in the reaction chamber center will be predicted in real-time based on early target position measurements. The system design, construction progress, and early testing results will be presented.

Petzoldt, R.W. [General Atomics (United States); Alexander, N.B. [General Atomics (United States); Drake, T.J. [General Atomics (United States); Goodin, D.T. [General Atomics (United States); Stemke, R.W. [General Atomics (United States); Jonestrask, K

2003-07-15T23:59:59.000Z

408

Key West, Florida: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

(Redirected from Key West, FL) (Redirected from Key West, FL) Jump to: navigation, search Equivalent URI DBpedia Coordinates 24.5557025°, -81.7825914° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":24.5557025,"lon":-81.7825914,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

409

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

August 2, 2011 - 9:20pm August 2, 2011 - 9:20pm Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Ashton B. Carter - Nominee for Deputy Secretary of Defense, Department of Defense I. Charles McCullough III - Inspector General of the Intelligence Community, Office of the Director of National Intelligence Ernest Mitchell, Jr. - Administrator, United States Fire Administration, Federal Emergency Management Agency, Department of Homeland Security Nancy M. Ware - Director, Court Services and Offender Supervision Agency for the District of Columbia Gregory H. Woods - General Counsel, Department of Energy The President also announced his intent to appoint the following individuals to key Administration posts:

410

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

July 27, 2011 - 3:25pm July 27, 2011 - 3:25pm Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: David Danielson - Assistant Secretary for Energy Efficiency and Renewable Energy, Department of Energy Dot Harris - Director of the Office of Minority Economic Impact, Department of Energy President Obama said, "I am honored that these talented individuals have decided to join this Administration and serve our country. I look forward to working with them in the months and years to come." President Obama announced his intent to nominate the following individuals to key Administration posts: David Danielson, Nominee for Assistant Secretary for Energy Efficiency and Renewable Energy, Department of Energy

411

Key Accomplishments @ Catalysis: Reactivity and Structure Group | Chemistry  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Recent Key Accomplishments Recent Key Accomplishments WGS: Importance of the Metal-Oxide Interface in Catalysis: In Situ Studies of the Water-Gas Shift Reaction by Ambient-Pressure X-ray Photoelectron Spectroscopy A New Type of Strong Metal-Support Interaction and the Production of H-2 through the Transformation of Water on Pt/CeO2(111) and Pt/CeOx/TiO2(110) Catalysts In situ studies of CeO2-supported Pt, Ru, and Pt-Ru alloy catalysts for the water-gas shift reaction: Active phases and reaction intermediates In situ/operando studies for the production of hydrogen through the water-gas shift on metal oxide catalysts Mechanistic understanding of WGS catalysts from first principles: Au(111) Supported Oxide Nanoparticles Theoretical catalyst optimization of WGS catalysts: Cu(111) supported oxide nanostructures

412

Contributions to Key Energy Conversion Technologies and Advanced Methods  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Contributions to Key Energy Conversion Technologies and Advanced Methods Contributions to Key Energy Conversion Technologies and Advanced Methods for Optimum Energy Systems Design and Planning Speaker(s): Daniel Favrat Date: February 27, 2003 - 12:00pm Location: Bldg. 90 Seminar Host/Point of Contact: Kristina LaCommare This presentation reviews some of EPFL-LENI's recent contributions to advanced cogeneration and heat pump technologies as well as to new system design approaches based on multimodal evolutionar algorithms. In the field of cogeneration, theoretical and experimental results show that gas engines with unscavenged ignition prechambers can, without the need of a catalyst, achieve high efficiencies with reasonable emissions with both natural gas and biogas. Combination with Organic Rankine Cycle (ORC) heat recovery

413

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

January 23, 2012 - 8:28pm January 23, 2012 - 8:28pm Addthis THE WHITE HOUSE Office of the Press Secretary FOR IMMEDIATE RELEASE January 23, 2012 President Obama Announces More Key Administration Posts WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Erin C. Conaton - Under Secretary of Defense for Personnel and Readiness, Department of Defense Scott H. DeLisi - Ambassador to the Republic of Uganda, Department of State Deborah Delisle - Assistant Secretary for Elementary and Secondary Education, Department of Education Tracey Ann Jacobson - Ambassador to the Republic of Kosovo, Department of State James J. Jones - Assistant Administrator for Toxic Substances, Environmental Protection Agency Frank Kendall III - Under Secretary of Defense for Acquisition,

414

Quantum hacking on quantum key distribution using homodyne detection  

Science Journals Connector (OSTI)

Imperfect devices in commercial quantum key distribution systems open security loopholes that an eavesdropper may exploit. An example of one such imperfection is the wavelength-dependent coupling ratio of the fiber beam splitter. Utilizing this loophole, the eavesdropper can vary the transmittances of the fiber beam splitter at the receiver's side by inserting lights with wavelengths different from what is normally used. Here, we propose a wavelength attack on a practical continuous-variable quantum key distribution system using homodyne detection. By inserting light pulses at different wavelengths, this attack allows the eavesdropper to bias the shot-noise estimation even if it is done in real time. Based on experimental data, we discuss the feasibility of this attack and suggest a prevention scheme by improving the previously proposed countermeasures.

Jing-Zheng Huang; Sébastien Kunz-Jacques; Paul Jouguet; Christian Weedbrook; Zhen-Qiang Yin; Shuang Wang; Wei Chen; Guang-Can Guo; Zheng-Fu Han

2014-03-05T23:59:59.000Z

415

Secure password-based authenticated key exchange for web services  

SciTech Connect (OSTI)

This paper discusses an implementation of an authenticated key-exchange method rendered on message primitives defined in the WS-Trust and WS-SecureConversation specifications. This IEEE-specified cryptographic method (AuthA) is proven-secure for password-based authentication and key exchange, while the WS-Trust and WS-Secure Conversation are emerging Web Services Security specifications that extend the WS-Security specification. A prototype of the presented protocol is integrated in the WSRF-compliant Globus Toolkit V4. Further hardening of the implementation is expected to result in a version that will be shipped with future Globus Toolkit releases. This could help to address the current unavailability of decent shared-secret-based authentication options in the Web Services and Grid world. Future work will be to integrate One-Time-Password (OTP) features in the authentication protocol.

Liang, Fang; Meder, Samuel; Chevassut, Olivier; Siebenlist, Frank

2004-11-22T23:59:59.000Z

416

Quantum Hacking on Quantum Key Distribution using Homodyne Detection  

E-Print Network [OSTI]

Imperfect devices in commercial quantum key distribution systems open security loopholes that an eavesdropper may exploit. An example of one such imperfection is the wavelength dependent coupling ratio of the fiber beam splitter. Utilizing this loophole, the eavesdropper can vary the transmittances of the fiber beam splitter at the receiver's side by inserting lights with wavelengths different from what is normally used. Here, we propose a wavelength attack on a practical continuous-variable quantum key distribution system using homodyne detection. By inserting light pulses at different wavelengths, this attack allows the eavesdropper to bias the shot noise estimation even if it is done in real time. Based on experimental data, we discuss the feasibility of this attack and suggest a prevention scheme by improving the previously proposed countermeasures.

Jing-Zheng Huang; Sébastien Kunz-Jacques; Paul Jouguet; Christian Weedbrook; Zhen-Qiang Yin; Shuang Wang; Wei Chen; Guang-Can Guo; Zheng-Fu Han

2014-02-27T23:59:59.000Z

417

THIS GUIDE IS INTENDED TO PROVIDE KEY INFORMATION to  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

THIS GUIDE IS INTENDED TO PROVIDE KEY INFORMATION to THIS GUIDE IS INTENDED TO PROVIDE KEY INFORMATION to policy makers on energy codes and to offer guidance on how policy makers can support the creation of statewide energy efficiency goals and standards. In addition, this guide will help instruct policy makers on how they can: » Encourage the adoption of statewide codes. » Establish energy code awareness programs. » Support enforcement of and compliance with energy codes. » Participate in the development of national codes and standards. » Determine the viability of the new code. Building TECHnOlOgiES PROgRAM Resource Guide for Policy Makers PREPAREd By Building Energy Codes Program The u.S. department of Energy's (uSdOE) Building Energy Codes Program (BECP) is an information resource on national energy codes. They work with other government

418

Keys to Profitable Texas Sweet Potato Production, Storage and Marketing.  

E-Print Network [OSTI]

8 8 8 8-1274 Texas Agricultural Extension Service. The Texas A&M UniverSity System . Daniel C. Pfannstlel, Director . College Station, Texas ACKNOWLEDGMENT The authors acknowledge the contribution to this publication by Dr. Charles Cole, area... Extension entomologist. KEYS TO PROFITABLE TEXAS SWEET POTATO PRODUCTION, STORAGE AND MARKETING Roland E. Roberts, Thomas D. Longbrake, Sam Cotner, Terry Menges, B. Dean McCraw and Donald R. Paterson* Texas growers and shippers produced more than 1...

Roberts, Roland E.; Longbrake, Thomas D.; Cotner, Sam; Menges, Terry; McCraw, B. Dean; Paterson, Donald R.

1979-01-01T23:59:59.000Z

419

Economy key to 1992 U. S. oil, gas demand  

SciTech Connect (OSTI)

This paper provides a forecast US oil and gas markets and industry in 1992. An end to economic recession in the U.S. will boost petroleum demand modestly in 1992 after 2 years of decline. U.S. production will resume its slide after a fractional increase in 1991. Drilling in the U.S. will set a record low. Worldwide, the key questions are economic growth and export volumes from Iraq, Kuwait, and former Soviet republics.

Beck, R.J.

1992-01-27T23:59:59.000Z

420

New Approach to Quantum Key Distribution Via Quantum Encryption  

E-Print Network [OSTI]

In this Paper, we investigate the security of Zhang, Li and Guo quantum key distribution via quantum encryption protocol [$\\text{Phys. Rev. A} \\textbf{64}, 24302 (2001)$] and show that it is not secure against some of Eve's attacks and with the probability one half she gets all of keys without being detected by the two parties. The main defect in this protocol is that there is an attack strategy by which Eve can change the previously shared Bell state between Alice and Bob to two Bell states among herself and Alice and Bob. Hence, we show that with probability $1/d$ its generalization to $d$-dimension systems is not secure and show that its extension to the case of more partners based on the reusable GHZ states is not secure and with probability one half Eve gets all of keys without being detected by the two parties. In what follows, we show how in going to higher dimensions those protocols can be repaired.

A. Fahmi

2006-04-25T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Independent Oversight Targeted Review, Oak Ridge National Laboratory...  

Office of Environmental Management (EM)

Targeted Review, Oak Ridge National Laboratory - April 2014 Independent Oversight Targeted Review, Oak Ridge National Laboratory - April 2014 April 2014 Targeted Review of...

422

NIF Target Chamber Dedicated | National Nuclear Security Administratio...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Dedicated NIF Target Chamber Dedicated June 11, 1999 NIF Target Chamber Dedicated Livermore, CA Secretary Richardson dedicates the National Ignition Facility target chamber at...

423

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network [OSTI]

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

424

Nano compartments may aid drug delivery, catalyst design > Archived...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nano compartments may aid drug delivery, catalyst design April 18th, 2013 By Bill Steele Spongelike nanoparticles whose pores can be filled with drugs offer the promise of drug...

425

E-Print Network 3.0 - access technologies key Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

electronic identifier (IdentiKey) including access and password requirements, account lockout... that are accessed using a university electronic identifier or IdentiKey. The...

426

A Comparison of Key PV Backsheet and Module Properties from Fielded...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

of Key PV Backsheet and Module Properties from Fielded Module Exposures and Accelerated Test Conditions A Comparison of Key PV Backsheet and Module Properties from Fielded Module...

427

E-Print Network 3.0 - adverse antiepileptic drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... Dosage Same or different? A drug in a different...

428

Targeted alpha therapy for cancer  

Science Journals Connector (OSTI)

Targeted alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer cells. The practicality and efficacy of TAT is tested by in vitro and in vivo studies in melanoma, leukaemia, colorectal, breast and prostate cancers, and by a phase 1 trial of intralesional TAT for melanoma. The alpha-emitting radioisotope used is Bi-213, which is eluted from the Ac-225 generator and chelated to a cancer specific monoclonal antibody (mab) or protein (e.g. plasminogen activator inhibitor-2 PAI2) to form the alpha-conjugate (AC). Stable alpha-ACs have been produced which have been tested for specificity and cytotoxicity in vitro against melanoma (9.2.27 mab), leukaemia (WM60), colorectal (C30.6), breast (PAI2, herceptin), ovarian (PAI2, herceptin, C595), prostate (PAI2, J591) and pancreatic (PAI2, C595) cancers. Subcutaneous inoculation of 1–1.5 million human cancer cells into the flanks of nude mice causes tumours to grow in all mice. Tumour growth is compared for untreated controls, nonspecific AC and specific AC, for local (subcutaneous) and systemic (tail vein or intraperitoneal) injection models. The 213Bi-9.2.27 AC is injected into secondary skin melanomas in stage 4 patients in a dose escalation study to determine the effective tolerance dose, and to measure kinematics to obtain the equivalent dose to organs. In vitro studies show that TAT is one to two orders of magnitude more cytotoxic to targeted cells than non-specific ACs, specific beta emitting conjugates or free isotopes. In vivo local TAT at 2 days post-inoculation completely prevents tumour formation for all cancers tested so far. Intra-lesional TAT can completely regress advanced sc melanoma but is less successful for breast and prostate cancers. Systemic TAT inhibits the growth of sc melanoma xenografts and gives almost complete control of breast and prostate cancer tumour growth. Intralesional doses up to 450 µCi in human patients are effective in regressing melanomas, with no concomitant complications. These results point to the application of local and systemic TAT in the management of secondary cancer. Results of the phase 1 clinical trial of TAT of subcutaneous, secondary melanoma indicate proof of the principle that TAT can make tumours in patients regress.

Barry J Allen; Chand Raja; Syed Rizvi; Yong Li; Wendy Tsui; David Zhang; Emma Song; Chang Fa Qu; John Kearsley; Peter Graham; John Thompson

2004-01-01T23:59:59.000Z

429

The dynamics of an epidemic model with targeted antiviral prophylaxis  

E-Print Network [OSTI]

Due to the increasing risk of drug resistance and side effects with large-scale antiviral use, it has been suggested to provide antiviral drugs only to susceptibles

2010-10-07T23:59:59.000Z

430

Tensor Target Polarization at TRIUMF  

SciTech Connect (OSTI)

The first measurements of tensor observables in $\\pi \\vec{d}$ scattering experiments were performed in the mid-80's at TRIUMF, and later at SIN/PSI. The full suite of tensor observables accessible in $\\pi \\vec{d}$ elastic scattering were measured: $T_{20}$, $T_{21}$, and $T_{22}$. The vector analyzing power $iT_{11}$ was also measured. These results led to a better understanding of the three-body theory used to describe this reaction. %Some measurements were also made in the absorption and breakup channels. A direct measurement of the target tensor polarization was also made independent of the usual NMR techniques by exploiting the (nearly) model-independent result for the tensor analyzing power at 90$^\\circ _{cm}$ in the $\\pi \\vec{d} \\rightarrow 2p$ reaction. This method was also used to check efforts to enhance the tensor polarization by RF burning of the NMR spectrum. A brief description of the methods developed to measure and analyze these experiments is provided.

Smith, G

2014-10-27T23:59:59.000Z

431

Bacteria-targeting nanoparticles for managing infections  

E-Print Network [OSTI]

Bacterial infections continue to be a significant concern particularly in healthcare settings and in the developing world. Current challenges include the increasing spread of drug resistant (DR) organisms, the side effects ...

Radovic-Moreno, Aleksandar Filip

2013-01-01T23:59:59.000Z

432

Book Review of Handbook of Drug Metabolism. Second Edition  

Science Journals Connector (OSTI)

Book Review of Handbook of Drug Metabolism. ... This book is divided into four sections: Fundamentals, Factors Affecting Drug Metabolism, Technologies, and Applications. ...

Jeffrey P. Jones

2009-06-22T23:59:59.000Z

433

Apoferritin-based nanomedicine platform for drug delivery: equilibrium...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA. Apoferritin-based nanomedicine platform for drug delivery: equilibrium...

434

Drugs and oil flow through the Eagle Ford Shale.  

E-Print Network [OSTI]

??This report is a work of original reporting which investigates the proliferation of drug use and drug trafficking in the Eagle Ford Shale, a region… (more)

Marks, Michael Perry

2014-01-01T23:59:59.000Z

435

Implementation Guidance, Drug Testing - December 3, 2007 | Department...  

Broader source: Energy.gov (indexed) [DOE]

Implementation Guidance, Drug Testing - December 3, 2007 Implementation Guidance, Drug Testing - December 3, 2007 December 3, 2007 Implementation guidance for applicants for, and...

436

Secretary Bodman's Memorandum Regarding Drug Testing at DOE ...  

Office of Environmental Management (EM)

Secretary Bodman's Memorandum Regarding Drug Testing at DOE Secretary Bodman's Memorandum Regarding Drug Testing at DOE September 14, 2007 In consideration of the report on the...

437

Alignment strategies for drug product process development and manufacturing .  

E-Print Network [OSTI]

??The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the… (more)

Garvin, Christopher John

2012-01-01T23:59:59.000Z

438

Memorandum, Drug Testing at DOE - September 14, 2007 | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

on the Consequences of a Positive Drug Test Secretary Bodman's Memorandum Regarding Drug Testing at DOE Environment Worker Health & Safety Nuclear Safety Facility Safety Security...

439

E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

440

Mathematical Modeling of HIV-1 Infection and Drug Therapy  

E-Print Network [OSTI]

also discuss how drug treatment affects the emergence of drug resistance during treatment, and how a low level of virus and latently infected cells can persist in.

2008-12-16T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile  

SciTech Connect (OSTI)

The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licenced as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Na{sub v}1.5 sodium and Ca{sub v}1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (? 10 ?M) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. - Highlights: • We study effects of anti-addiction drug ibogaine on ionic currents in cardiomyocytes. • We assess the cardiac ion channel profile of ibogaine. • Ibogaine inhibits hERG potassium, sodium and calcium channels. • Ibogaine’s effects on ion channels are a potential source of cardiac arrhythmias. • 18-Methoxycoronaridine has a lower affinity for cardiac ion channels than ibogaine.

Koenig, Xaver; Kovar, Michael; Rubi, Lena; Mike, Agnes K.; Lukacs, Peter; Gawali, Vaibhavkumar S.; Todt, Hannes [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Hilber, Karlheinz, E-mail: karlheinz.hilber@meduniwien.ac.at [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Sandtner, Walter [Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna (Austria)

2013-12-01T23:59:59.000Z

442

Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays  

Science Journals Connector (OSTI)

...perturbation of a key signaling node can have consequences on pathway activation that can be assessed...perturbations in one pathway may have unforeseen consequences on interacting pathways that may affect...mechanisms they control: the simple truth about complex networks. Nat Rev Drug...

Zachary S. Boyd; Qun Jenny Wu; Carol O'Brien; Jill Spoerke; Heidi Savage; Paul J. Fielder; Lukas Amler; Yibing Yan; Mark R. Lackner

2008-12-01T23:59:59.000Z

443

Drug Shows Promise for Advanced Disease  

Science Journals Connector (OSTI)

...session of the congress that the drug memantine significantly slowed the progression...transmit their signals. In contrast, memantine turns down the activity of the so-called...damage in Alzheimer's. In Germany, memantine has been approved for treating dementias...

Jean Marx

2000-07-21T23:59:59.000Z

444

NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM  

E-Print Network [OSTI]

Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

Hart, Steven N.

2011-02-22T23:59:59.000Z

445

Conflict of interest over Harvard drug  

Science Journals Connector (OSTI)

... an unusually candid statement released last week by Harvard Medical School, Dean Daniel C. Tosteson acknowledged that a "significant conflict of interest occurred" in a drug study undertaken by ...

Seth Shulman

1988-10-27T23:59:59.000Z

446

Pollution from drug manufacturing: review and perspectives  

Science Journals Connector (OSTI)

...19] and Europe [9,14] as pollution sources, with concentrations of...the picture of pharmaceutical pollution from manufacturing is still highly...for some drugs, possibly even air pollution. 2. Effect studies A number of...

2014-01-01T23:59:59.000Z

447

Transformational Energy Action Management (TEAM) Wireless Energy Efficiency Keys Initiative  

Broader source: Energy.gov (indexed) [DOE]

by by Transformational Energy Action Management (TEAM) Wireless Energy Efficiency Keys Initiative *Ways of Using Wireless Technology to Help You Reduce Energy Usage at your Facility Together with our industry partners, we strive to: * Accelerate adoption of the many energy-efficient technologies and practices available today * Conduct vigorous technology innovation to radically improve future energy diversity, resource efficiency, and carbon mitigation * Promote a corporate culture of energy efficiency and carbon management What Is the Industrial Technologies Program ? The Industrial Technologies Program (ITP) is the lead federal agency responsible for improving energy efficiency in the largest energy-using sector of the country. Industrial Sector National Initiative

448

Local structures - key to improved gas adsorption in carbon materials |  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Functional Materials for Energy Functional Materials for Energy Local structures - key to improved gas adsorption in carbon materials September 23, 2013 (Inset, top left) A simulated disordered carbon structure. (Inset, bottom right) Same structure, with dense colored regions showing the strongest adsorption positions. (Main figure) Isosteric heat of adsorption as a function of carbon density, showing the strong change of adsorption with pore size. Combined results from electron microscopy, neutron scattering, and theory, illustrate the link between local structures and adsorption properties in carbon materials. The achieved understanding at the atomic scale is a crucial step towards predicting and designing materials with enhanced gas adsorption properties, with important implications for applications such as

449

Decoy-state quantum key distribution using homodyne detection  

SciTech Connect (OSTI)

In this paper, we propose to use the decoy-state technique to improve the security of the quantum key distribution (QKD) systems based on homodyne detection against the photon number splitting attack. The decoy-state technique is a powerful tool that can significantly boost the secure transmission range of the QKD systems. However, it has not yet been applied to the systems that use homodyne detection. After adapting this theory to the systems based on homodyne detection, we quantify the secure performance and transmission range of the resulting system.

Shams Mousavi, S. H. [Ecole Superieure d'Electricite (Supelec), Photonic and Communication Systems, 2 rue Edouard Belin, 57070 Metz (France); Gallion, P. [TELECOM ParisTech, Ecole Nationale Superieure des Telecommunications, CNRS LTCI UMR 5141, 46 rue Barrault, 75013 Paris (France)

2009-07-15T23:59:59.000Z

450

Secure Quantum Key Distribution using Continuous Variables of Single Photons  

Science Journals Connector (OSTI)

We analyze the distribution of secure keys using quantum cryptography based on the continuous variable degree of freedom of entangled photon pairs. We derive the information capacity of a scheme based on the spatial entanglement of photons from a realistic source, and show that the standard measures of security known for quadrature-based continuous variable quantum cryptography (CV-QKD) are inadequate. A specific simple eavesdropping attack is analyzed to illuminate how secret information may be distilled well beyond the bounds of the usual CV-QKD measures.

Lijian Zhang; Christine Silberhorn; Ian A. Walmsley

2008-03-18T23:59:59.000Z

451

2014 CATEE: Collaboration is the Key- Public/Private Partnerships  

E-Print Network [OSTI]

, Texas Nov. 18-20 HGOC Education and Outreach ? District Meetings ? Peer Exchange ? Workshops ? Webinars ? One-on-One Trainings ? Newsletters ? Social media ESL-KT-14-11-24 CATEE 2014: Clean Air Through Efficiency Conference, Dallas, Texas Nov. 18...2014 CATEE Collaboration is the Key - Public/Private Partnerships November 19, 2014 Lisa Lin, Sustainability Manager, City of Houston ESL-KT-14-11-24 CATEE 2014: Clean Air Through Efficiency Conference, Dallas, Texas Nov. 18-20 City of Houston...

Lin, L.

2014-01-01T23:59:59.000Z

452

Design and Testing of a Prototype Spallation Neutron Source Rotating Target Assembly  

SciTech Connect (OSTI)

The mechanical aspects of an extended vertical shaft rotating target have been evaluated in a full-scale mockup test. A prototype assembly based on a conceptual target design for a 1 to 3-MW spallation facility was built and tested. Key elements of the drive/coupling assembly implemented in the prototype include high integrity dynamic face seals, commercially available bearings, realistic manufacturing tolerances, effective monitoring and controls, and fail-safe shutdown features. A representative target disk suspended on a 3.5 meter prototypical shaft was coupled with the drive to complete the mechanical tests. After1800 hours of operation the test program has confirmed the overall mechanical feasibility of the extended vertical shaft rotating target concept. Precision alignment of the suspended target disk; successful containment of the water and verification of operational stability over the full speed range of 30 to 60 rpm were primary indications the proposed mechanical design is valid for use in a high power target station.

Rennich, Mark J [ORNL; McManamy, Thomas J [ORNL; Graves, Van [Oak Ridge National Laboratory (ORNL); Garmendia, Amaia Zarraoa [IDOM Bilbao; Sorda, Fernando [ESS Bilbao

2010-01-01T23:59:59.000Z

453

A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human  

SciTech Connect (OSTI)

A general toxicity of basic drugs is related to phospholipidosis in tissues. Therefore, it is essential to predict the tissue distribution of basic drugs to facilitate an initial estimate of that toxicity. The objective of the present study was to further assess the original prediction method that consisted of using the binding to red blood cells measured in vitro for the unbound drug (RBCu) as a surrogate for tissue distribution, by correlating it to unbound tissue:plasma partition coefficients (Kpu) of several tissues, and finally to predict volume of distribution at steady-state (V{sub ss}) in humans under in vivo conditions. This correlation method demonstrated inaccurate predictions of V{sub ss} for particular basic drugs that did not follow the original correlation principle. Therefore, the novelty of this study is to provide clarity on the actual hypotheses to identify i) the impact of pharmacological mode of action on the generic correlation of RBCu-Kpu, ii) additional mechanisms of tissue distribution for the outlier drugs, iii) molecular features and properties that differentiate compounds as outliers in the original correlation analysis in order to facilitate its applicability domain alongside the properties already used so far, and finally iv) to present a novel and refined correlation method that is superior to what has been previously published for the prediction of human V{sub ss} of basic drugs. Applying a refined correlation method after identifying outliers would facilitate the prediction of more accurate distribution parameters as key inputs used in physiologically based pharmacokinetic (PBPK) and phospholipidosis models.

Poulin, Patrick, E-mail: patrick-poulin@videotron.ca [Quebec City, Quebec (Canada); Ekins, Sean [Collaborations in Chemistry, 601 Runnymede Avenue, Jenkintown, PA 19046 (United States); Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, MD 21201 (United States); Department of Pharmacology, University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854 (United States); Theil, Frank-Peter [Genentech, South San Francisco (United States)

2011-01-15T23:59:59.000Z

454

Explanations of FreedomCAR/DOE Hydrogen Storage Technical Targets  

Broader source: Energy.gov [DOE]

Summary of FreedomCAR Targets and Basis for Targets prepared for the Grand Challenge Hydrogen Storage Solicitation.

455

Multimodality Imaging with Silica-Based Targeted Nanoparticle Platforms  

SciTech Connect (OSTI)

Objectives: To synthesize and characterize a C-Dot silica-based nanoparticle containing 'clickable' groups for the subsequent attachment of targeting moieties (e.g., peptides) and multiple contrast agents (e.g., radionuclides with high specific activity) [1,2]. These new constructs will be tested in suitable tumor models in vitro and in vivo to ensure maintenance of target-specificity and high specific activity. Methods: Cy5 dye molecules are cross-linked to a silica precursor which is reacted to form a dye-rich core particle. This core is then encapsulated in a layer of pure silica to create the core-shell C-Dot (Figure 1) [2]. A 'click' chemistry approach has been used to functionalize the silica shell with radionuclides conferring high contrast and specific activity (e.g. 64Cu and 89Zr) and peptides for tumor targeting (e.g. cRGD and octreotate) [3]. Based on the selective Diels-Alder reaction between tetrazine and norbornene, the reaction is bioorthogonal, highyielding, rapid, and water-compatible. This radiolabeling approach has already been employed successfully with both short peptides (e.g. octreotate) and antibodies (e.g. trastuzumab) as model systems for the ultimate labeling of the nanoparticles [1]. Results: PEGylated C-Dots with a Cy5 core and labeled with tetrazine have been synthesized (d = 55 nm, zeta potential = -3 mV) reliably and reproducibly and have been shown to be stable under physiological conditions for up to 1 month. Characterization of the nanoparticles revealed that the immobilized Cy5 dye within the C-Dots exhibited fluorescence intensities over twice that of the fluorophore alone. The nanoparticles were successfully radiolabeled with Cu-64. Efforts toward the conjugation of targeting peptides (e.g. cRGD) are underway. In vitro stability, specificity, and uptake studies as well as in vivo imaging and biodistribution investigations will be presented. Conclusions: C-Dot silica-based nanoparticles offer a robust, versatile, and multi-functional platform to enhance in vivo detection sensitivity and non-invasively assay receptor expression/status of tumor cellular targets, including those of low abundance, using nuclear-NIR fluorescence imaging approaches [2]. Improvements in molecular diagnostics, refined by the availability of nanotechnology platforms, will be a key determinant in driving early-stage disease detection and prevention, ultimately leading to decreases in mortality.

Jason S. Lewis

2012-04-09T23:59:59.000Z

456

DOE Targets Rural Indiana Geologic Formation for CO2 Storage Field Test |  

Broader source: Energy.gov (indexed) [DOE]

DOE Targets Rural Indiana Geologic Formation for CO2 Storage Field DOE Targets Rural Indiana Geologic Formation for CO2 Storage Field Test DOE Targets Rural Indiana Geologic Formation for CO2 Storage Field Test November 12, 2009 - 12:00pm Addthis Washington, DC - A U.S. Department of Energy (DOE) team of regional partners has begun injecting 8,000 tons of carbon dioxide (CO2) to evaluate the carbon storage potential and test the enhanced oil recovery (EOR) potential of the Mississippian-aged Clore Formation in Posey County, Ind. Carbon capture and storage (CCS) is seen as a key technology for reducing greenhouse gas emissions and helping to mitigate climate change. The injection, which is expected to last 6-8 months, is an integral step in DOE's Regional Carbon Sequestration Partnership program. The Midwest Geological Sequestration Consortium (MGSC) is conducting the field test to

457

The Changing Face of Teenage Drug Abuse — The Trend toward Prescription Drugs  

Science Journals Connector (OSTI)

...friends, or on the Internet." They can also get them all too easily from physicians, according to recent data from the National Center on Addiction and Substance Abuse at Columbia University. A 2004 survey of physicians found that 43 percent did not ask about prescription-drug abuse when taking a patient's... Dr. Richard Friedman describes an emerging pattern in drug use by teenagers: illicit street drugs such as “ecstasy” and cocaine are decreasing in popularity, whereas the nonmedical use of certain prescription drugs is on the rise.

Friedman R.A.

2006-04-06T23:59:59.000Z

458

Type classification, color estimation, and specific target detection of moving targets on public streets  

Science Journals Connector (OSTI)

This paper describes a vision system that recognizes moving targets such as vehicles and pedestrians on public streets. This system can: (1) classify targets {vehicle, pedestrian, others} and, for "vehicles," discriminate vehicle types and (2) estimate ...

Osamu Hasegawa; Takeo Kanade

2005-02-01T23:59:59.000Z

459

THE ROTATING TARGET FLOW TEST FACILITY  

E-Print Network [OSTI]

@idom.com) Fernando Sordo, ESS Bilbao Tom McManamy, ORNL/SNS #12;Status of the RTFT 4th HPTW of a RotaAng Target for ESS · In 2009 ESS Bilbao worked out a preliminary design for a rotaZng target for ESS. · Disc formed by un-clad tungsten bricks cooled

McDonald, Kirk

460

Target Options for a Neutrino Factory  

E-Print Network [OSTI]

shield WC 6. Target station engineering Target integration Remote maintenance Shielding 7. Beam dump 7a possible/preferable? · Can the beam size be increased (from 1.2 mm (rms) baseline)? #12;Heat loads ­ Heating and material damage Issues ­ Heat load from 4 MW pulsed proton beam · Total Heat load

McDonald, Kirk

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Transmission Line MTF: Magnetized Target Fusion  

E-Print Network [OSTI]

Transmission Line MTF: Magnetized Target Fusion Initial target: preheated & magnetized Subsequent for the FRC. Abstract Block Diagram theta coil transmission line Bias cap. bank maincapacitor inductor PI cap compression to fusion conditions Magnetic field of at least 5 T in a closed-field line topology Density ~ 1017

462

ENVIRONMENTAL MANAGEMENT SYSTEM OBJECTIVES AND TARGETS  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Objectives & Targets Rev. 7/17/13 Objectives & Targets Rev. 7/17/13 ENVIRONMENTAL MANAGEMENT SYSTEM OBJECTIVES AND TARGETS 2012 PROGRESS REPORT for SOUTHWESTERN POWER ADMINISTRATION Activity Legal Requirement Aspect Objective Target** see important note Target Achieved Details Real Estate Management DOE O 436.1 E.O. 13423 & 13514 EPAct 1992 and 2005 EISA 2007 NECPA 1978 Natural resource depletion and GHG emissions from resource intensive facilities Increase sustainability of facility resources, reduce energy and water consumption, reduce impacts to natural resources from facility usage 1) Meter 90% of electricity by September 2012 2) Meter 90% of gas, steam, and water by September 2015 3) 30% energy intensity reduction by 2015 from baseline 2003 4) Reduce water consumption intensity 2%

463

You Are A Target | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

You Are A Target You Are A Target You Are A Target November 6, 2013 1:00PM EST Course Title: You Are A Target Course Start/End Date: November 6, 2013 Start/End Time: 1:00 pm - 2:00 pm Course Type: Classrooom. The Meet-Me-Conference number for presentations on 11/6/2013 is 301-903-0117, reservation #447671. Both presentations on 11/6/2013 will be available via VTC. The Germantown room # is B-025. Please contact HQ DOE VTC at vtc@doe.gov or call 301-903-4555 to add your site to the bridge (i.e., 4600). Course Location: Forrestal Large Auditorium Course Description: "You Are A Target" presentation by Lance Spitzner, Training Director, SANS Securing the Human Program. Every October and November, the Department of Energy (DOE) joins the Department of Homeland Security (DHS) and other federal, state and local agencies across the

464

Spherical Target Temperature by Extended CFAST Calculation  

SciTech Connect (OSTI)

The purpose of this calculation is to evaluate the temperature at the surface of a spherical target made of polyethylene during a room fire. The current calculation is separated into 2 steps: (1) CFAST code calculation--Calculate the air temperature; radiation flux to the target from the fire, surrounding air, and walls; convection flux; and target temperature. (2) Extended model calculation--Calculate the temperature of the target sphere taking into account the density, heat capacity, heat conductivity, and the spherical geometry of the target by solving the coupled finite difference equations. The second step calculation utilizes the air temperature and radiation flux determined by the CFAST code calculation in the first step.

Ma, C W

2009-05-05T23:59:59.000Z

465

Cooperative target convergence using multiple agents  

SciTech Connect (OSTI)

This work considers the problem of causing multiple (100`s) autonomous mobile robots to converge to a target and provides a follow-the-leader approach to the problem. Each robot has only a limited-range sensor for sending the target and also larger but also limited-range robot-to-robot communication capability. Because of the small amount of information available to the robots, a practical approach to improve convergence to the target is to have a robot follow the robot with the best quality of information. Specifically, each robot emits a signal that informs in-range robots what its status is. A robot has a status value of 0 if it is itself in range of the target. A robot has a status of 1 if it is not in range of the target but is in communication range of a robot that is in range of the target. A robot has a status of 2 if it is not in range of the target but is within range of another robot that has status 1, and so on. Of all the mobile robots that any given robot is in range of, it follows the one with the best status. The emergent behavior is the ant-like trails of robots following each other toward the target. If the robot is not in range of another robot that is either in range of the target or following another robot, the robot will assign-1 to its quality-of-information, and will execute an exhaustive search. The exhaustive search will continue until it encounters either the target or another robot with a nonnegative quality-of-information. The quality of information approach was extended to the case where each robot only has two-bit signals informing it of distance to in-range robots.

Kwok, K.S.; Driessen, B.J.

1997-10-01T23:59:59.000Z

466

FORMATION OF A PHYSICALLY STABLE AMORPHOUS DRUG COMPLEX  

E-Print Network [OSTI]

ABSTRACT In this paper we explore the use of Neusilin, an inorganic magnesium aluminometasilicate, to stabilize the amorphous form of an acidic drug a neutral drug and two basic drugs. Both cryomilling and ball milling of the drug with Neusilin were...

MacLean, Jenifer Anne

2010-12-16T23:59:59.000Z

467

Paclitaxel-Loaded PEG-PE–Based Micellar Nanopreparations Targeted with Tumor-Specific Landscape Phage Fusion Protein Enhance Apoptosis and Efficiently Reduce Tumors  

Science Journals Connector (OSTI)

...chemotherapy in cancer treatment include insufficient...for breast cancer treatment, paclitaxel is...agents used for the treatment of metastatic breast...micellar targeting of water-insoluble drugs...vortexing and overnight dialysis against PBS (pH...by transmission electronic microscopy (TEM...

Tao Wang; Shenghong Yang; Leslie A. Mei; Chirag K. Parmar; James W. Gillespie; Kulkarni P. Praveen; Valery A. Petrenko; and Vladimir P. Torchilin

2014-12-01T23:59:59.000Z

468

High Affinity Inha Inhibitors with Activity Against Drug-Resistant Strains of Mycobacterium Tuberculosis  

SciTech Connect (OSTI)

Novel chemotherapeutics for treating multidrug-resistant (MDR) strains of Mycobacterium tuberculosis (MTB) are required to combat the spread of tuberculosis, a disease that kills more than 2 million people annually. Using structure-based drug design, we have developed a series of alkyl diphenyl ethers that are uncompetitive inhibitors of InhA, the enoyl reductase enzyme in the MTB fatty acid biosynthesis pathway. The most potent compound has a Ki{prime} value of 1 nM for InhA and MIC{sub 99} values of 2-3 {micro}g mL{sup -1} (6-10 {micro}M) for both drug-sensitive and drug-resistant strains of MTB. Overexpression of InhA in MTB results in a 9-12-fold increase in MIC{sub 99}, consistent with the belief that these compounds target InhA within the cell. In addition, transcriptional response studies reveal that the alkyl diphenyl ethers fail to upregulate a putative efflux pump and aromatic dioxygenase, detoxification mechanisms that are triggered by the lead compound triclosan. These diphenyl ether-based InhA inhibitors do not require activation by the mycobacterial KatG enzyme, thereby circumventing the normal mechanism of resistance to the front line drug isoniazid (INH) and thus accounting for their activity against INH-resistant strains of MTB.

Sullivan,T.; Truglio, J.; Boyne, M.; Novichenok, P.; Zhang, X.; Stratton, C.; Li, H.; Kaur, T.; Amin, A.; et al.

2006-01-01T23:59:59.000Z

469

Investing in Oil and Natural Gas A Few Key Issues  

U.S. Energy Information Administration (EIA) Indexed Site

Strategic Advisors in Global Energy Strategic Advisors in Global Energy Strategic Advisors in Global Energy Strategic Advisors in Global Energy Investing in Oil and Natural Gas: A Few Key Issues Prepared for EIA Conference Susan Farrell, Senior Director PFC Energy April 8, 2009 Investing in Oil and Gas| PFC Energy| Page 2 The Top 20 IOCs and Top 20 NOCs Account for Over Half of E&P Spend Source: PFC Energy, Global E&P Surveys Investing in Oil and Gas| PFC Energy| Page 3 Oil Prices Rose, But So Did Costs + 52% $0 $20 $40 $60 $80 $100 $120 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 WTI $/barrel Annual averages Large Gulf of Mexico Facility Costs by Segment Avg $28.31 Avg $59.13 Source: PFC Energy Investing in Oil and Gas| PFC Energy| Page 4 Near term Spending Cuts will be Significant

470

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

December 9, 2009 - 12:00am December 9, 2009 - 12:00am Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Patricia A. Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, Department of Energy Mari Del Carmen Aponte, Ambassador to the Republic of El Salvador, Department of State Donald E. Booth, Ambassador to the Federal Democratic Republic of Ethiopia, Department of State Larry Persily, Federal Coordinator for Alaska Natural Gas Transportation Projects President Obama said, "The depth of experience these individuals bring to their roles will be valuable to my administration as we work to bring about real change for the American people. I look forward to working with them in

471

Nano Changes Have Macro Importance for a Key Electronics Material |  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Squeezing an Old Material Could Yield "Instant-On" Memory Squeezing an Old Material Could Yield "Instant-On" Memory A Metal That Becomes Transparent under Pressure Under Pressure, Atoms Make Unlikely Alloys Slowing Down Near the Glass Transition New Light on Improving Engine Efficiencies Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Nano Changes Have Macro Importance for a Key Electronics Material APRIL 23, 2009 Bookmark and Share Original image courtesy of http://www.freefoto.com By combining the results from several powerful techniques for studying materials structure at the nanoscale, including work at the U.S. Department of Energy's Advanced Photon Source (APS) at Argonne National Laboratory,

472

LANL to play key role in biofuel development  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biofuel development Biofuel development LANL to play key role in biofuel development LANL to create a proof-of-concept system for commercializing algae-based biofuels or other advanced biofuels that can be transported and sold using the nation's existing fueling infrastructure. January 14, 2010 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

473

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

April 17, 2009 - 12:00am April 17, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Christine M. Griffin, Deputy Director of Office of Personnel Management; Kevin Concannon, Under Secretary for Food, Nutrition and Consumer Services, United States Department of Agriculture; Rajiv Shah, Under Secretary for Research, Education, and Economics, United States Department of Agriculture; Michael Nacht, Assistant Secretary of Defense (Global Strategic Affairs), Department of Defense; Mercedes Márquez, Assistant Secretary for Community Planning and Development, Department of Housing and Urban Development; Raymond M. Jefferson, Assistant Secretary for Veterans Employment and Training, Department of Labor; Robert S. Litt, General

474

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

December 10, 2010 - 12:00am December 10, 2010 - 12:00am Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Peter B. Lyons, Assistant Secretary for Nuclear Energy, Department of Energy Denise E. O'Donnell, Director of the Bureau of Justice Assistance, Department of Justice Stephanie O'Sullivan, Principal Deputy Director of National Intelligence, Directorate of National Intelligence David Shear, Ambassador to the Socialist Republic of Vietnam, Department of State The President also announced his intent to appoint Harvey S. Wineberg as a Member of the President's Advisory Council on Financial Capability. His biography is below. President Obama said, "The American people will be greatly served by the

475

Potential Benefits from Improved Energy Efficiency of Key Electrical Products:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

8254 8254 Potential Benefits from Improved Energy Efficiency of Key Electrical Products: The Case of India Michael McNeil, Maithili Iyer, Stephen Meyers, Virginie Letschert, James E. McMahon Environmental Energy Technologies Division Lawrence Berkeley National Laboratory University of California, Berkeley Berkeley, CA December 2005 This work was supported by the International Copper Association through the U.S. Department of Energy under Contract No. DE-AC03-76SF00098. 2 ABSTRACT The goal of this project was to estimate the net benefits that cost-effective improvements in energy efficiency can bring to developing countries. The study focused on four major electrical products in the world's second largest developing country, India. These

476

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

July 8, 2009 - 12:00am July 8, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Joe Garcia, Director of the Office of Minority Economic Impact, Department of Energy Michael H. Posner, Assistant Secretary of State for Democracy, Human Rights, and Labor, Department of State Stephen J. Rapp, Ambassador at Large for War Crimes Issues, Department of State Alexander G. Garza, Assistant Secretary for Health Affairs and Chief Medical Officer, Department of Homeland Security Susan L. Kurland, Assistant Secretary for Aviation and International Affairs, Department of Transportation Kenneth A. Spearman, Member of the Board of Directors, Farm Credit Administration Rolena Adorno, Member of the National Council on the Humanities

477

President Obama Announces More Key Administration Posts | Department of  

Broader source: Energy.gov (indexed) [DOE]

4, 2009 - 12:00am 4, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Daniel B. Poneman, Deputy Secretary, Department of Energy; Fred P. Hochberg, President and Chairman of the Export-Import Bank of the United States; Francisco "Frank" J. Sánchez, Under Secretary for International Trade, Department of Commerce; Miriam E. Sapiro, Deputy Trade Representative; Judith A. McHale, Under Secretary for Public Diplomacy and Public Affairs, Department of State; Philip J. "P.J." Crowley, Assistant Secretary of State for Public Affairs, Department of State; Bonnie D. Jenkins, Coordinator for Threat Reduction Programs (with the Rank of Ambassador), Department of

478

City of Key West, Florida (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

Florida (Utility Company) Florida (Utility Company) Jump to: navigation, search Name Key West City of Place Florida Utility Id 10226 Utility Location Yes Ownership M NERC Location FRCC NERC FRCC Yes Operates Generating Plant Yes Activity Generation Yes Activity Transmission Yes Activity Buying Transmission Yes Activity Distribution Yes Alt Fuel Vehicle Yes Alt Fuel Vehicle2 Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Governmental Recreational Facility Lighting (Schedule S-3) LED High Watt, Approx. 72 Watt (Street Light Schedule S-1) Lighting LED High Watt, Approx. 72 Watts (Area Lighting Schedule S-2) Lighting

479

LANL breaks ground on key sediment control project  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sediment control project Sediment control project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately $2 million features are up to eight feet high and made of rocks packed tightly into wire enclosures. November 5, 2009 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

480

Wind power in electricity markets: key issues and challenges  

Science Journals Connector (OSTI)

Due to the large penetration and continuous improvement in the wind power technology, wind farms are asked to operate similar to the conventional power plants. In emerging electricity market, wind power generators are now seen differently and should sustain with/without limited government support. Although cost reductions due to technological improvements bring wind power in competitions to conventional fossil-fuel generation, but until now various incentives are required to overcome wind power's cost disadvantage and these incentives may play a significant role in improving the competitiveness of wind power. However, the use and trade of wind power in the market is complicated because of the lack of guarantees of generation, mainly in the wind farms. This paper discusses several key issues and challenges which can be faced by the wind power in the competitive power market. With suitable market mechanism, wind power can be helpful in mitigating the market abuse up to some extent.

B.S. Rajpurohit; S.N. Singh; Istvan Erlich

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "key drug target" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Using a drug-word Stroop task to differentiate recreational from dependent drug use  

E-Print Network [OSTI]

, Garavan H. A consistent attentional bias for drug-related material in active cocaine users across word and picture versions of the emotional Stroop task. Drug Alcohol Depend. 2006;81(3):251–257. 38. Franken IHA, Kroon LY, Wiers RW, Jansen A. Selective...

Smith, Dana G.; Ersche, Karen D.

2014-03-14T23:59:59.000Z

482

Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance  

E-Print Network [OSTI]

period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

Clairambault, Jean

483

Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer  

DOE Patents [OSTI]

Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.

Hu, Zhi (El Cerrito, CA); Kuo, Wen-Lin (San Ramon, CA); Neve, Richard M. (San Mateo, CA); Gray, Joe W. (San Francisco, CA)

2012-06-12T23:59:59.000Z

484

Drug Testing for New Clearance Holders  

Broader source: Energy.gov (indexed) [DOE]

Drug Testing Prerequisite for DOE Security Clearance Applicants Drug Testing Prerequisite for DOE Security Clearance Applicants The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Current Status Clearance Action Test Required? Uncleared - Applicant Grant (Q/L, T/S/C) Yes Previously Cleared DOE-now uncleared DOE Reinstate (Q/L, T/S/C) Yes* Coming from another Federal agency, regardless of clearance status Grant (Q/L, T/S/C) Yes**

485

Drug Testing for New Clearance Holders  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug Testing Prerequisite for DOE Security Clearance Applicants Drug Testing Prerequisite for DOE Security Clearance Applicants The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Current Status Clearance Action Test Required? Uncleared - Applicant Grant (Q/L, T/S/C) Yes Previously Cleared DOE-now uncleared DOE Reinstate (Q/L, T/S/C) Yes* Coming from another Federal agency, regardless of clearance status Grant (Q/L, T/S/C) Yes**

486

Protein-Based Nanomedicine Platforms for Drug Delivery  

SciTech Connect (OSTI)

Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drug’s efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

2009-08-03T23:59:59.000Z

487

Energy Efficiency Targets | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Targets Targets Energy Efficiency Targets < Back Eligibility Investor-Owned Utility Program Info State Arkansas Program Type Energy Efficiency Resource Standard In December of 2010, the Arkansas Public Service Commission announced a [http://www.apscservices.info/pdf/08/08-144-U_153_1.pdf Sustainable Energy Resource Action Plan] for Arkansas. Along with this comprehensive plan, the Commission issued 10 Orders directing the state's four electric and three natural gas investor-owned utilities to implement the energy efficiency measures described in the Action Plan. These orders were passed on December 10, 2010. Order 17 in Docket 08-144-U sets sales reductions targets for both electric and gas utilities. The PSC directed these utilities to file comprehensive energy efficiency plans for 2011, 2012, and 2013 with incremental energy

488

Table II: Technical Targets for Membranes: Automotive  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

II: Technical Targets for Membranes: Automotive II: Technical Targets for Membranes: Automotive All targets must be achieved simultaneously Characteristics Units Calendar year 2000 status a 2005 2010 Membrane conductivity, operating temperature Ω-cm -1 0.1 0.1 0.1 Room temperature Ω-cm -1 -20 o C Ω-cm -1 Oxygen cross-over b mA/cm 2 5 5 2 Hydrogen cross-over b mA/cm 2 5 5 2 Cost $/kW 50 5 Operating Temperature o C 80 120 120 Durability Hours 1000 d >4000 e >5000 f Survivability c o C -20 -30 -40 Thermal cyclability in presence of condensed water yes yes yes Notes: a) Status is present day 80 o C unless otherwise noted; targets are for new membranes/CCMs b) Tested in CCM c) Indicates temperature from which bootstrapping stack must be achieved

489

Perspectives on Global Change: the TARGETS Approach  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Perspectives on Global Change: the TARGETS Approach Perspectives on Global Change: the TARGETS Approach Speaker(s): Bert DeVries Date: February 6, 1998 - 12:00pm Location: 90-3148 Seminar Host/Point of Contact: Richard Sextro TARGETS is a simulation model designed to help explore the future of the world innovatively and to search for adequate operationalization of the concept of sustainable development. It incorporates a unique approach to the study of long-term global change and sustainability issues. The model is distinguished by its treatment of uncertainties through explicit formulation of cultural perspectives on controversial issues, and by its inclusion of a visualisation tool to enable transparent and interactive presentation of scenario analyses. TARGETS embodies an interdisciplinary approach, deals explictly with both physical and socio-economic

490

Statistical Modeling of Single Target Cell Encapsulation  

E-Print Network [OSTI]

High throughput drop-on-demand systems for separation and encapsulation of individual target cells from heterogeneous mixtures of multiple cell types is an emerging method in biotechnology that has broad applications in ...

Moon, SangJun

491

Targeting cancer metabolism: a therapeutic window opens  

E-Print Network [OSTI]

Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

Vander Heiden, Matthew G.

492

OMEGA Targets - Laboratory for Laser Energetics  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Targets - Laboratory for Laser Energetics Laboratory for Laser Energetics Logo Search Home Around the Lab Past Issues Past Quick Shots About Office of the Director Map to LLE LLE...

493

SNS Target R&D Presented by  

E-Print Network [OSTI]

since been resolved ­ QA program would have to be very stringent for long lifetime Second target station implemented #12;11 Managed by UT-Battelle for the U.S. Department of Energy Spallation Neutron Source

McDonald, Kirk

494

EMC effect: asymptotic freedom with nuclear targets  

SciTech Connect (OSTI)

General features of the EMC effect are discussed within the framework of quantum chromodynamics as expressed via the operator product expansion and asymptotic freedom. These techniques are reviewed with emphasis on the target dependence. 22 references.

West, G.B.

1984-01-01T23:59:59.000Z

495

UKNF 12 January 2005 Target Studies  

E-Print Network [OSTI]

the cryogenics. · MHD calculations of the behaviour of the mercury jet. · take part in the experiment at CERN cooled vacuum chamber Schematic diagram of the test chamber and heater oven. #12;Pbar Target Tests Pbar

McDonald, Kirk

496

Nanotechnology-mediated targeting of tumor angiogenesis  

E-Print Network [OSTI]

Abstract Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging strategy for the development of therapies targeting tumor-associated angiogenesis is to harness the potential of nanotechnology ...

Banerjee, Deboshri

497

Source prestige and target reactions to threats  

Science Journals Connector (OSTI)

A 3 by 2 design was employed to study the effects of source capability and of punishment magnitude on the compliance of target individuals to contingent threats intermittently sent by a simulated source in...

Thomas V. Bonoma; Barry R. Schlenker; R. Bob Smith…

1970-08-01T23:59:59.000Z

498

Analysis of Climate Policy Targets under Uncertainty  

E-Print Network [OSTI]

Although policymaking in response to the climate change is essentially a challenge of risk management, most studies of the relation of emissions targets to desired climate outcomes are either deterministic or subject to a ...

Jacoby, Henry D.

499

Target Visualization at the National Ignition Facility  

SciTech Connect (OSTI)

As the National Ignition Facility continues its campaign to achieve ignition, new methods and tools will be required to measure the quality of the targets used to achieve this goal. Techniques have been developed to measure target surface features using a phase-shifting diffraction interferometer and Leica Microsystems confocal microscope. Using these techniques we are able to produce a detailed view of the shell surface, which in turn allows us to refine target manufacturing and cleaning processes. However, the volume of data produced limits the methods by which this data can be effectively viewed by a user. This paper introduces an image-based visualization system for data exploration of target shells at the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory. It aims to combine multiple image sets into a single visualization to provide a method of navigating the data in ways that are not possible with existing tools.

Potter, D

2011-11-21T23:59:59.000Z

500

From Integrative Genomics to Therapeutic Targets  

Science Journals Connector (OSTI)

...Research. 15 June 2013 review-article Reviews From Integrative Genomics to Therapeutic Targets Rachael Natrajan Paul Wilkerson Corresponding...conventional pathology with genomic profiling and functional genomics have begun to enhance our understanding of the genetic basis...

Rachael Natrajan and Paul Wilkerson

2013-06-15T23:59:59.000Z