National Library of Energy BETA

Sample records for key drug target

  1. Automated High Throughput Drug Target Crystallography

    SciTech Connect (OSTI)

    Rupp, B

    2005-02-18

    The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

  2. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally ... transcription and replication and is a prime target of antibacterial and anticancer drugs. ...

  3. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has ...

  4. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II

  5. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  6. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  7. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  8. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  9. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  10. TARGET SELECTION FOR THE LBTI EXOZODI KEY SCIENCE PROGRAM

    SciTech Connect (OSTI)

    Weinberger, Alycia J.; Bryden, Geoff; Mennesson, Bertrand; Serabyn, Eugene; Kennedy, Grant M.; Wyatt, Mark C.; Roberge, Aki; Danchi, William C.; Stapelfeldt, Karl R.; Defrère, Denis; Hinz, Philip M.; Rieke, George; Bailey, Vanessa P.; Skemer, Andrew J.; Millan-Gabet, Rafael; Haniff, Chris

    2015-02-01

    The Hunt for Observable Signatures of Terrestrial planetary Systems (HOSTS) on the Large Binocular Telescope Interferometer will survey nearby stars for faint emission arising from ∼300 K dust (exozodiacal dust), and aims to determine the exozodiacal dust luminosity function. HOSTS results will enable planning for future space telescopes aimed at direct spectroscopy of habitable zone terrestrial planets, as well as greater understanding of the evolution of exozodiacal disks and planetary systems. We lay out here the considerations that lead to the final HOSTS target list. Our target selection strategy maximizes the ability of the survey to constrain the exozodi luminosity function by selecting a combination of stars selected for suitability as targets of future missions and as sensitive exozodi probes. With a survey of approximately 50 stars, we show that HOSTS can enable an understanding of the statistical distribution of warm dust around various types of stars and is robust to the effects of varying levels of survey sensitivity induced by weather conditions.

  11. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M.; Nikanjam, Mina

    2012-08-28

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  12. Increasing the structural coverage of tuberculosis drug targets

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Baugh, Loren; Phan, Isabelle; Begley, Darren W.; Clifton, Matthew C.; Armour, Brianna; Dranow, David M.; Taylor, Brandy M.; Muruthi, Marvin M.; Abendroth, Jan; Fairman, James W.; et al

    2014-12-19

    High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus “homolog-rescue” strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. We found that of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structuresmore » would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Cα RMSD <1 Å, >85% side chain identity, and ≥80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.« less

  13. International Experience with Key Program Elements of IndustrialEnergy Efficiency or Greenhouse Gas Emissions Reduction Target-SettingPrograms

    SciTech Connect (OSTI)

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-02-02

    Target-setting agreements, also known as voluntary ornegotiated agreements, have been used by a number of governments as amechanism for promoting energy efficiency within the industrial sector. Arecent survey of such target-setting agreement programs identified 23energy efficiency or GHG emissions reduction voluntary agreement programsin 18 countries. International best practice related to target-settingagreement programs calls for establishment of a coordinated set ofpolicies that provide strong economic incentives as well as technical andfinancial support to participating industries. The key program elementsof a target-setting program are the target-setting process,identification of energy-saving technologies and measures usingenergy-energy efficiency guidebooks and benchmarking as well as byconducting energy-efficiency audits, development of an energy-savingsaction plan, development and implementation of energy managementprotocols, development of incentives and supporting policies, monitoringprogress toward targets, and program evaluation. This report firstprovides a description of three key target-setting agreement programs andthen describes international experience with the key program elementsthat comprise such programs using information from the three keytarget-setting programs as well as from other international programsrelated to industrial energy efficiency or GHG emissionsreductions.

  14. Key Elements of and Materials Performance Targets for Highly Insulating Window Frames

    SciTech Connect (OSTI)

    Gustavsen, Arild; Grynning, Steinar; Arasteh, Dariush; Jelle, Bjorn Petter; Goudey, Howdy

    2011-03-28

    The thermal performance of windows is important for energy efficient buildings. Windows typically account for about 30-50 percent of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U-factor of their opaque counterparts (wall, roof and floor constructions). In well insulated buildings the U-factor of walls, roofs an floors can be between 0.1-0.2 W/(m2K). The best windows have U-values of about 0.7-1.0. It is therefore obvious that the U-factor of windows needs to be reduced, even though looking at the whole energy balance for windows (i.e. solar gains minus transmission losses) makes the picture more complex.In high performance windows the frame design and material use is of utmost importance, as the frame performance is usually the limiting factor for reducing the total window U-factor further. This paper describes simulation studies analyzing the effects on frame and edge-of-glass U-factors of different surface emissivities as well as frame material and spacer conductivities. The goal of this work is to define materials research targets for window frame components that will result in better frame thermal performance than is exhibited by the best products available on the market today.

  15. Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite for targeted drug delivery

    SciTech Connect (OSTI)

    Gu, Lina; He, Xiaomei; Wu, Zhenyu

    2014-11-15

    Highlights: Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite was synthesized by a simple, efficient and environmental friendly method. The prepared material had a large surface area, high pore volume, and good magnetic separability. DOX-loaded Fe{sub 3}O{sub 4}/hydroxyapatite composite exhibited surprising slow drug release behavior and pH-dependent behavior. - Abstract: In this contribution, we introduced a simple, efficient, and green method of preparing a mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite (HA) composite. The as-prepared material had a large surface area, high pore volume, and good magnetic separability, which made it suitable for targeted drug delivery systems. The chemotherapeutic agent doxorubicin (DOX) was used to investigate the drug release behavior of Fe{sub 3}O{sub 4}/HA composite. The drug release profiles displayed a little burst effect and pH-dependent behavior. The release rate of DOX at pH 5.8 was larger than that at pH 7.4, which could be attributed to DOX protonation in acid medium. In addition, the released DOX concentrations remained at 0.83 and 1.39 ?g/ml at pH 7.4 and 5.8, respectively, which indicated slow, steady, and safe release rates. Therefore, the as-prepared Fe{sub 3}O{sub 4}/hydroxyapatite composite could be an efficient platform for targeted anticancer drug delivery.

  16. Sandia, UCLA develop screening libraries to discover drug targets for viral

    National Nuclear Security Administration (NNSA)

    infections | National Nuclear Security Administration | (NNSA) Sandia, UCLA develop screening libraries to discover drug targets for viral infections Friday, April 22, 2016 - 12:00am From left, Sandia National Laboratories researchers Oscar Negrete, Edwin Saada and Sara Bird check out a CRISPR library preparation. The work is part of the first-ever Cooperative Research and Development Agreement between Sandia and UCLA. As headlines highlight the threat of viruses like Ebola and Zika,

  17. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Forte, Trudy

    2011-04-28

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  18. Targets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    that require a complex interplay among target designers, materials scientists, and ... As a result, target components must be machined to an accuracy of 1 micron, or 1 millionth ...

  19. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo; Ji, Nan; Pan, Wen; Hong, Ru; Wang, Hao; Ji, Zhi-Liang

    2014-01-01

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: A novel computational framework was developed for mechanistic study of SADRs. Off-targets of drugs were identified in large scale and in a high-throughput manner. SADRs like cardiac disorders were systematically explored in molecular networks. A number of ADR-associated proteins were identified.

  20. Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion

    SciTech Connect (OSTI)

    Knobloch, M.; Portier, C.J.; Levionnois, O.L.; Theurillat, R.; Thormann, W.; Spadavecchia, C.; Mevissen, M. . E-mail: meike.mevissen@vpi.unibe.ch

    2006-11-01

    Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 {mu}g/ml S-ketamine over 120 min under isoflurane anesthesia was performed in Shetland ponies. A quantitative electromyographic assessment of the NWR was done before, during and after the TCI. Plasma levels of R-/S-ketamine and R-/S-norketamine were determined by enantioselective capillary electrophoresis. These data and two additional data sets from bolus studies were used to build a PBPk model for ketamine in ponies. The peak-to-peak amplitude and the duration of the NWR decreased significantly during TCI and returned slowly toward baseline values after the end of TCI. The PBPk model provides reliable prediction of plasma and tissue levels of R- and S-ketamine and R- and S-norketamine. Furthermore, biotransformation of ketamine takes place in the liver and in the lung via first-pass metabolism. Plasma concentrations of S-norketamine were higher compared to R-norketamine during TCI at all time points. Analysis of the data suggested identical biotransformation rates from the parent compounds to the principle metabolites (R- and S-norketamine) but different downstream metabolism to further metabolites. The PBPk model can provide predictions of R- and S-ketamine and norketamine concentrations in other clinical settings (e.g. horses)

  1. Target

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lifetime measurements in inverse kinematics Coulex Target e.g. C Stopper e.g. Cu Beam X X * C Si-Det. Yale Plunger 120 Te at 300 MeV Plunger foils Si-Detector Compton-suppressed ...

  2. KEY PERSONNEL

    National Nuclear Security Administration (NNSA)

    by Mods 002, 006, 020, 029, 0049, 0065, 0084, 0091, 0106) DE-NA0000622 Section J, Appendix J, Page 1 SECTION J APPENDIX J KEY PERSONNEL 7/06/2015 TITLE NAME President Christopher C. Gentile Vice President, Engineering Robin Stubenhofer Vice President, Integrated Supply Chain Rick Lavelock Director, Sr. Program Management Org. Vacant Director, Integrated Supply Chain Kurt Lorenzen Director, Engineering Bob Chaney Director, Quality David Schoenherr Director, Information Technology Matt Decker

  3. Key Outcomes:

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Points & Action Items Inaugural Meeting Thursday, August 25, 2011 Renaissance Denver Hotel Denver, Colorado Participants Tracey LeBeau, Director, Pilar Thomas, Deputy Director, and Brandt Petrasek, Special Assistant, Department of Energy, Office of Indian Energy Policy and Programs; Vice Chairman Ronald Suppah and Jim Manion, Confederated Tribes of the Warm Springs Reservation of Oregon; William Micklin, Ewiiaapaayp Band of Kumeyaay Indians; Councilman Barney Enos, Jr., Jason Hauter,

  4. Key Activities

    Broader source: Energy.gov [DOE]

    We partner with industry, small business, universities, regional entities, and other stakeholders to identify and invest in emerging clean energy technologies. We establish collaborative communities focused on developing and commercializing targeted technologies; play a leadership role in the national interagency Advanced Manufacturing Partnership; and encourage a culture of continuous improvement in corporate energy management. Our investments have high impact, use project diversity to spread risk, target nationally important innovation at critical decision points, and contribute to quantifiable energy savings. By reducing the life-cycle energy consumption of manufactured goods by 50 percent over 10 years, we will support the creation of high-quality domestic manufacturing jobs and enhance the competitiveness of the United States. EERE's Clean Energy Manufacturing Initiative (CEMI) connects AMO's investments in the development of innovative process and materials technologies over 3 decades with R&D in other EERE offices and focuses on the urgent economic opportunities in U.S. clean energy manufacturing to strengthen U.S. competitiveness across multiple manufacturing industries through increased energy productivity.

  5. Identification of a Novel Drug Lead That Inhibits HCV Infection and Cell-to-Cell Transmission by Targeting the HCV E2 Glycoprotein

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Al Olaby, Reem R.; Cocquerel, Laurence; Zemla, Adam; Saas, Laure; Dubuisson, Jean; Vielmetter, Jost; Marcotrigiano, Joseph; Khan, Abdul Ghafoor; Catalan, Felipe Vences; Perryman, Alexander L.; et al

    2014-10-30

    We report that Hepatitis C Virus (HCV) infects 200 million individuals worldwide. Although several FDA approved drugs targeting the HCV serine protease and polymerase have shown promising results, there is a need for better drugs that are effective in treating a broader range of HCV genotypes and subtypes without being used in combination with interferon and/or ribavirin. Recently, two crystal structures of the core of the HCV E2 protein (E2c) have been determined, providing structural information that can now be used to target the E2 protein and develop drugs that disrupt the early stages of HCV infection by blocking E2’smore » interaction with different host factors. Using the E2c structure as a template, we have created a structural model of the E2 protein core (residues 421–645) that contains the three amino acid segments that are not present in either structure. Computational docking of a diverse library of 1,715 small molecules to this model led to the identification of a set of 34 ligands predicted to bind near conserved amino acid residues involved in the HCV E2: CD81 interaction. We used surface plasmon resonance detection to screen the ligand set for binding to recombinant E2 protein, and the best binders were subsequently tested to identify compounds that inhibit the infection of Huh-7 cells by HCV. One compound, 281816, blocked E2 binding to CD81 and inhibited HCV infection in a genotype-independent manner with IC50’s ranging from 2.2 µM to 4.6 µM. 281816 blocked the early and late steps of cell-free HCV entry and also abrogated the cell-to-cell transmission of HCV. Collectively the results obtained with this new structural model of E2c suggest the development of small molecule inhibitors such as 281816 that target E2 and disrupt its interaction with CD81 may provide a new paradigm for HCV treatment.« less

  6. Identification of a Novel Drug Lead That Inhibits HCV Infection and Cell-to-Cell Transmission by Targeting the HCV E2 Glycoprotein

    SciTech Connect (OSTI)

    Al Olaby, Reem R.; Cocquerel, Laurence; Zemla, Adam; Saas, Laure; Dubuisson, Jean; Vielmetter, Jost; Marcotrigiano, Joseph; Khan, Abdul Ghafoor; Catalan, Felipe Vences; Perryman, Alexander L.; Freundlich, Joel S.; Forli, Stefano; Levy, Shoshana; Balhorn, Rod; Azzazy, Hassan M.

    2014-10-30

    We report that Hepatitis C Virus (HCV) infects 200 million individuals worldwide. Although several FDA approved drugs targeting the HCV serine protease and polymerase have shown promising results, there is a need for better drugs that are effective in treating a broader range of HCV genotypes and subtypes without being used in combination with interferon and/or ribavirin. Recently, two crystal structures of the core of the HCV E2 protein (E2c) have been determined, providing structural information that can now be used to target the E2 protein and develop drugs that disrupt the early stages of HCV infection by blocking E2’s interaction with different host factors. Using the E2c structure as a template, we have created a structural model of the E2 protein core (residues 421–645) that contains the three amino acid segments that are not present in either structure. Computational docking of a diverse library of 1,715 small molecules to this model led to the identification of a set of 34 ligands predicted to bind near conserved amino acid residues involved in the HCV E2: CD81 interaction. We used surface plasmon resonance detection to screen the ligand set for binding to recombinant E2 protein, and the best binders were subsequently tested to identify compounds that inhibit the infection of Huh-7 cells by HCV. One compound, 281816, blocked E2 binding to CD81 and inhibited HCV infection in a genotype-independent manner with IC50’s ranging from 2.2 µM to 4.6 µM. 281816 blocked the early and late steps of cell-free HCV entry and also abrogated the cell-to-cell transmission of HCV. Collectively the results obtained with this new structural model of E2c suggest the development of small molecule inhibitors such as 281816 that target E2 and disrupt its interaction with CD81 may provide a new paradigm for HCV treatment.

  7. Key Agency Targets Summary _FY 2012_.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    all projects in the capital work plan; and 3) At least 80% of Capital Allocation Board (CAB) approved "major capital investment" projectprogram elements of cost, schedule, and...

  8. NSR Key Number Retrieval

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NSR Key Number Retrieval Pease enter key in the box Submit

  9. Study reveals structure of tuberculosis enzyme, could offer drug...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of tuberculosis enzyme, could offer drug target By Louise Lerner * November 2, 2015 Tweet ... Researchers have been interested in the mycobacterium IMPDH enzyme as a drug target for ...

  10. Prescription Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue...

  11. Key Steps | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Steps The Postdoctoral Program Office welcomes you to Argonne National Laboratory. Your academic achievements and demonstrated research capabilities will undoubtedly contribute to the continuing scientific and technological success of the Laboratory. It is our intention that your tenure at Argonne be as productive and rewarding as possible. Your goals and needs may evolve as you progress through your appointment. We take the approach of providing guidance, resources and programs targeted to

  12. Public Key Cryptography and Key Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-02-15

    The use and management of certificate-based public key cryptography for the Department of Energy (DOE) requires the establishment of a public key infrastructure (PKI). This chapter defines the policy related to roles, requirements, and responsibilities for establishing and maintaining a DOE PKI and the documentation necessary to ensure that all certificates are managed in a manner that maintains the overall trust required to support a viable PKI. Canceled by DOE N 251.112.

  13. Group key management

    SciTech Connect (OSTI)

    Dunigan, T.; Cao, C.

    1997-08-01

    This report describes an architecture and implementation for doing group key management over a data communications network. The architecture describes a protocol for establishing a shared encryption key among an authenticated and authorized collection of network entities. Group access requires one or more authorization certificates. The implementation includes a simple public key and certificate infrastructure. Multicast is used for some of the key management messages. An application programming interface multiplexes key management and user application messages. An implementation using the new IP security protocols is postulated. The architecture is compared with other group key management proposals, and the performance and the limitations of the implementation are described.

  14. Key Milestones/Outlook

    Office of Energy Efficiency and Renewable Energy (EERE)

    Key Milestones/Outlook per the Department of Energy 2015 Congressional Budget Request, Environmental Management, March 2014

  15. Quantum dense key distribution

    SciTech Connect (OSTI)

    Degiovanni, I.P.; Ruo Berchera, I.; Castelletto, S.; Rastello, M.L.; Bovino, F.A.; Colla, A.M.; Castagnoli, G.

    2004-03-01

    This paper proposes a protocol for quantum dense key distribution. This protocol embeds the benefits of a quantum dense coding and a quantum key distribution and is able to generate shared secret keys four times more efficiently than the Bennet-Brassard 1984 protocol. We hereinafter prove the security of this scheme against individual eavesdropping attacks, and we present preliminary experimental results, showing its feasibility.

  16. Key Events Timeline

    Broader source: Energy.gov [DOE]

    This document lists key events beginning with the April 20 fire on the Deepwater Horizon through July 28th. Updated July 28, 2010.

  17. SSH Key Fingerprints

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SSH Key Fingerprints SSH Key Fingerprints Occasionally maintenance on NERSC systems results in the SSH host key changing. On the first time you attempt to log in after this, ssh will stop with a warning like: "WARNING: REMOTE HOST IDENTIFICATION HAS CHANGED!" (Linux/Mac) or "WARNING - POTENTIAL SECURITY BREACH!" (Windows) Do not ignore these warnings! The correct host key fingerprint for Cori is: 2048 SHA256:mR3sHwHorgjqRlUbggtfOCa768/uKdbNb2TOH8xDMn8 You can replace entries

  18. Targeting the tumor microenvironment

    SciTech Connect (OSTI)

    Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

    2006-11-07

    Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

  19. Optical key system

    SciTech Connect (OSTI)

    Hagans, Karla G.; Clough, Robert E.

    2000-01-01

    An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

  20. Optical key system

    SciTech Connect (OSTI)

    Hagans, K.G.; Clough, R.E.

    2000-04-25

    An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

  1. Public Key FPGA Software

    Energy Science and Technology Software Center (OSTI)

    2013-07-25

    The Public Key (PK) FPGA software performs asymmetric authentication using the 163-bit Elliptic Curve Digital Signature Algorithm (ECDSA) on an embedded FPGA platform. A digital signature is created on user-supplied data, and communication with a host system is performed via a Serial Peripheral Interface (SPI) bus. Software includes all components necessary for signing, including custom random number generator for key creation and SHA-256 for data hashing.

  2. Key Activities | Department of Energy

    Energy Savers [EERE]

    About the Fuel Cell Technologies Office Key Activities Key Activities The Fuel Cell Technologies Office conducts work in several key areas to advance the development and ...

  3. Cryptographic Key Management System

    SciTech Connect (OSTI)

    No, author

    2014-02-21

    This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

  4. Target Chamber

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Who Partners with NIF? FAQs Visit Us home about how nif works beamline target chamber Target Chamber The "Grand Central Station" of the National Ignition Facility is the ...

  5. NREL Makes Key Appointments

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Makes Key Appointments Staffing for Distributed Energy and Tech Management Announced For more information contact: Gary Schmitz, 303-275-4050 email: Gary Schmitz Golden, Colo., Feb. 28, 2001 - Two veterans of energy research have been named to newly created positions at the U.S. Department of Energy's National Renewable Energy Laboratory. Jack Darnell was named Deputy Associate Director for NREL's recently reorganized Planning and Technology Management Division. Anthony Schaffhauser has been

  6. Sputter target

    DOE Patents [OSTI]

    Gates, Willard G.; Hale, Gerald J.

    1980-01-01

    The disclosure relates to an improved sputter target for use in the deposition of hard coatings. An exemplary target is given wherein titanium diboride is brazed to a tantalum backing plate using a gold-palladium-nickel braze alloy.

  7. Key Terms | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Terms Key Terms Three Door Keys data-key-571156_960_720.png Key Terms Low Vision: non-correctable reduced vision Blindness: lack of visual perception Hearing Impairment: full or partial decrease in the ability to detect or understand sounds Physical Impairment: a physical condition that permanently prevents normal body movement or control Cognitive Disabilities: difficulty with one or more types of mental tasks

  8. Secure key storage and distribution

    SciTech Connect (OSTI)

    Agrawal, Punit

    2015-06-02

    This disclosure describes a distributed, fault-tolerant security system that enables the secure storage and distribution of private keys. In one implementation, the security system includes a plurality of computing resources that independently store private keys provided by publishers and encrypted using a single security system public key. To protect against malicious activity, the security system private key necessary to decrypt the publication private keys is not stored at any of the computing resources. Rather portions, or shares of the security system private key are stored at each of the computing resources within the security system and multiple security systems must communicate and share partial decryptions in order to decrypt the stored private key.

  9. LIQUID TARGET

    DOE Patents [OSTI]

    Martin, M.D.; Salsig, W.W. Jr.

    1959-01-13

    A liquid handling apparatus is presented for a liquid material which is to be irradiated. The apparatus consists essentially of a reservoir for the liquid, a target element, a drain tank and a drain lock chamber. The target is in the form of a looped tube, the upper end of which is adapted to be disposed in a beam of atomic particles. The lower end of the target tube is in communication with the liquid in the reservoir and a means is provided to continuously circulate the liquid material to be irradiated through the target tube. Means to heat the reservoir tank is provided in the event that a metal is to be used as the target material. The apparatus is provided with suitable valves and shielding to provide maximum safety in operation.

  10. Key Activities | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    About the Bioenergy Technologies Office » Key Activities Key Activities The Bioenergy Technologies Office's key activities are aimed at producing a viable, sustainable domestic biomass industry that produces renewable biofuels, bioproducts and biopower; enhances U.S. energy security; reduces U.S. oil dependence; provides environmental benefits (e.g., reduced greenhouse gas emissions); and creates nationwide economic opportunities. Meeting these goals requires significant and rapid advances in

  11. Diversity & Flexibility Key to Sustainability

    Broader source: Energy.gov [DOE]

    Plenary V: Biofuels and Sustainability: Acknowledging Challenges and Confronting MisconceptionsDiversity & Flexibility Key to SustainabilityDavid Babson, Senior Fuels Engineer, Union of...

  12. Key Issues | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Issues Key Issues The following presentations offer information about other key topics related to high performance homes. wall_system_innovations_kochkin.pdf (1.48 MB) removing_codes_barriers_cole.pdf (479.86 KB) testing_residential_ariconditioners_booten_winkler.pdf (5.21 MB) code_gaps_combustion_safety.pdf (1.34 MB) automated_utility_bill_calibration_polly.pdf (1.64 MB) predicting_envelope_leakage_griffiths.pdf (1.63 MB) More Documents & Publications Code Gaps and Future Research Needs

  13. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein...

  14. Target assembly

    DOE Patents [OSTI]

    Lewis, Richard A.

    1980-01-01

    A target for a proton beam which is capable of generating neutrons for absorption in a breeding blanket includes a plurality of solid pins formed of a neutron emissive target material disposed parallel to the path of the beam and which are arranged axially in a plurality of layers so that pins in each layer are offset with respect to pins in all other layers, enough layers being used so that each proton in the beam will strike at least one pin with means being provided to cool the pins. For a 300 mA, 1 GeV beam (300 MW), stainless steel pins, 12 inches long and 0.23 inches in diameter are arranged in triangular array in six layers with one sixth of the pins in each layer, the number of pins being such that the entire cross sectional area of the beam is covered by the pins with minimum overlap of pins.

  15. Key China Energy Statistics 2011

    SciTech Connect (OSTI)

    Levine, Mark; Fridley, David; Lu, Hongyou; Fino-Chen, Cecilia

    2012-01-15

    The China Energy Group at Lawrence Berkeley National Laboratory (LBNL) was established in 1988. Over the years the Group has gained recognition as an authoritative source of China energy statistics through the publication of its China Energy Databook (CED). In 2008 the Group published the Seventh Edition of the CED (http://china.lbl.gov/research/chinaenergy-databook). This handbook summarizes key statistics from the CED and is expressly modeled on the International Energy Agency’s “Key World Energy Statistics” series of publications. The handbook contains timely, clearly-presented data on the supply, transformation, and consumption of all major energy sources.

  16. Key China Energy Statistics 2012

    SciTech Connect (OSTI)

    Levine, Mark; Fridley, David; Lu, Hongyou; Fino-Chen, Cecilia

    2012-05-01

    The China Energy Group at Lawrence Berkeley National Laboratory (LBNL) was established in 1988. Over the years the Group has gained recognition as an authoritative source of China energy statistics through the publication of its China Energy Databook (CED). The Group has published seven editions to date of the CED (http://china.lbl.gov/research/chinaenergy-databook). This handbook summarizes key statistics from the CED and is expressly modeled on the International Energy Agency’s “Key World Energy Statistics” series of publications. The handbook contains timely, clearly-presented data on the supply, transformation, and consumption of all major energy sources.

  17. Accelerator target

    DOE Patents [OSTI]

    Schlyer, David J.; Ferrieri, Richard A.; Koehler, Conrad

    1999-01-01

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  18. Accelerator target

    DOE Patents [OSTI]

    Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

    1999-06-29

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

  19. Novel targeted therapy for stomach cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Novel targeted therapy for stomach cancer Novel targeted therapy for stomach cancer This finding has the potential to save thousand of lives a year by delivering a more effective, targeted treatment for cancer patients. October 29, 2015 New research at Los Alamos National Laboratory and the Wellcome Trust Sanger Institute shows a molecular fingerprint in stomach cancer that shows it can be treated with platinum drugs and/or molecular inhibitors known as PARP (poly ADP ribose polymerase). New

  20. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent A Key Enzyme to the Potency of an Anticancer Agent Print Wednesday, 28 May 2008 00:00 Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid

  1. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  2. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  3. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  4. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  5. NREL: Energy Analysis - Key Activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Activities NREL conducts a broad range of energy analysis in support of the laboratory's programs and initiatives, DOE's Office of Energy Efficiency and Renewable Energy (EERE), technology transfer, and the greater energy analysis community. NREL's recent analysis activities include: Analysis of Project Finance Electric Sector Integration Energy-Water Nexus Life Cycle Assessment Harmonization Manufacturing Analysis Resource Assessment Printable Version Energy Analysis Home Capabilities &

  6. Smarter Drugs: How Protein Crystallography Revolutionizes Drug Design

    SciTech Connect (OSTI)

    Smith, Clyde

    2005-04-26

    According to Smith, protein crystallography allows scientists to design drugs in a much more efficient way than the standard methods traditionally used by large drug companies, which can cost close to a billion dollars and take 10 to 15 years. 'A lot of the work can be compressed down,' Smith said. Protein crystallography enables researchers to learn the structure of molecules involved in disease and health. Seeing the loops, folds and placement of atoms in anything from a virus to a healthy cell membrane gives important information about how these things work - and how to encourage, sidestep or stop their functions. Drug design can be much faster when the relationship between structure and function tells you what area of a molecule to target. Smith will use a timeline to illustrate the traditional methods of drug development and the new ways it can be done now. 'It is very exciting work. There have been some failures, but many successes too.' A new drug to combat the flu was developed in a year or so. Smith will tell us how. He will also highlight drugs developed to combat HIV, Tuberculosis, hypertension and Anthrax.

  7. Targeting NRF2 signaling for cancer chemoprevention

    SciTech Connect (OSTI)

    Kwak, Mi-Kyoung; Kensler, Thomas W.

    2010-04-01

    Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

  8. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  9. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  10. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  11. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  12. Keys to improving environmental performance

    SciTech Connect (OSTI)

    Moreau, R.L.; Raught, D.L.

    1996-11-01

    Environmental protection is a mainstream issue in today`s society. Both internal and external drivers motivate the oil and ms industry to continuously improve environmental performance. Companies are integrating environmental considerations into their business plans to a greater extent, and are directing proportionally more resources toward managing these issues. This paper addresses several environmental management focus areas in Exxon`s domestic E&P sector to: (1) manage risks, (2) ensure compliance, (3) improve performance, and (4) assist in the development of balanced legislation and regulations. Specific examples of Production Department programs are discussed, along with keys to success for continued progress in improving performance.

  13. Public/private key certification authority and key distribution. Draft

    SciTech Connect (OSTI)

    Long, J.P.; Christensen, M.J.; Sturtevant, A.P.; Johnston, W.E.

    1995-09-25

    Traditional encryption, which protects messages from prying eyes, has been used for many decades. The present concepts of encryption are built from that heritage. Utilization of modern software-based encryption techniques implies much more than simply converting files to an unreadable form. Ubiquitous use of computers and advances in encryption technology coupled with the use of wide-area networking completely changed the reasons for utilizing encryption technology. The technology demands a new and extensive infrastructure to support these functions. Full understanding of these functions, their utility and value, and the need for an infrastructure, takes extensive exposure to the new paradigm. This paper addresses issues surrounding the establishment and operation of a key management system (i.e., certification authority) that is essential to the successful implementation and wide-spread use of encryption.

  14. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Brain Receptor Structures Key to Future Therapeutics Print Wednesday, 28 January 2015 00:00 With an aging population in ...

  15. Key Opportunities and Challenges for Program Sustainability ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Opportunities and Challenges for Program Sustainability Key Opportunities and Challenges for Program Sustainability Better Buildings Neighborhood Program, Peer Exchange Call: ...

  16. 'Thirsty' Metals Key to Longer Battery Lifetimes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    'Thirsty' Metals Key to Longer Battery Lifetimes 'Thirsty' Metals Key to Longer Battery Lifetimes Computations at NERSC show how multiply charged metal ions impact battery capacity ...

  17. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Target 2 Target 2 is housed in ...

  18. Targets and target wheel mechanism for APEX

    SciTech Connect (OSTI)

    Roa, D.E.

    1995-10-01

    A rotating target wheel system built for the ATLAS Positron Experiment (APEX) will be described. It is designed so that targets can withstand the heating caused by the energy loss of intense heavy ion beams. A unique feature is the use of a digital encoder to provide logic trigger signals for beam sweeping and event-by-event target location information. Techniques for fabricating targets of tantalum, lead, thorium and uranium and the behavior of the targets during beam exposure will be discussed.

  19. Bioenergy Key Publications | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Publications Bioenergy Key Publications This overview highlights key publications issued by the U.S. Department of Energy's Bioenergy Technologies Office. bioenergy_key_publications.pdf (333.56 KB) More Documents & Publications 2013 Peer Review Presnentations-Plenaries Technology Pathway Selection Effort 2015 Peer Review Presentations-Plenaries

  20. Answering Key Fuel Cycle Questions

    SciTech Connect (OSTI)

    Steven J. Piet; Brent W. Dixon; J. Stephen Herring; David E. Shropshire; Mary Lou Dunzik-Gougar

    2003-10-01

    The Advanced Fuel Cycle Initiative (AFCI) program has both “outcome” and “process” goals because it must address both waste already accumulating as well as completing the fuel cycle in connection with advanced nuclear power plant concepts. The outcome objectives are waste geological repository capacity and cost, energy security and sustainability, proliferation resistance, fuel cycle economics, and safety. The process objectives are readiness to proceed and adaptability and robustness in the face of uncertainties. A classic decision-making approach to such a multi-attribute problem would be to weight individual quantified criteria and calculate an overall figure of merit. This is inappropriate for several reasons. First, the goals are not independent. Second, the importance of different goals varies among stakeholders. Third, the importance of different goals is likely to vary with time, especially the “energy future.” Fourth, some key considerations are not easily or meaningfully quantifiable at present. Instead, at this point, we have developed 16 questions the AFCI program should answer and suggest an approach of determining for each whether relevant options improve meeting each of the program goals. We find that it is not always clear which option is best for a specific question and specific goal; this helps identify key issues for future work. In general, we suggest attempting to create as many win-win decisions (options that are attractive or neutral to most goals) as possible. Thus, to help clarify why the program is exploring the options it is, and to set the stage for future narrowing of options, we have developed 16 questions, as follows: · What are the AFCI program goals? · Which potential waste disposition approaches do we plan for? · What are the major separations, transmutation, and fuel options? · How do we address proliferation resistance? · Which potential energy futures do we plan for? · What potential external triggers do we

  1. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  2. The Brain: Key To a Better Computer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain: Key To a Better Computer - Sandia Energy Energy Search Icon Sandia Home Locations ... Twitter Google + Vimeo Newsletter Signup SlideShare The Brain: Key To a Better Computer ...

  3. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P.

    1993-01-01

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  4. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  5. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. About Target 2 - Lead Slowing ...

  6. Advanced Target Effects Modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advanced Target Effects Modeling for Ion Accelerators and other High-Energy-Density ... ature effects, e.g., surface tension and target fragmentation, that are not generally ...

  7. Drug interactions evaluation: An integrated part of risk assessment of therapeutics

    SciTech Connect (OSTI)

    Zhang, Lei; Reynolds, Kellie S.; Zhao, Ping; Huang, Shiew-Mei

    2010-03-01

    Pharmacokinetic drug interactions can lead to serious adverse events or decreased drug efficacy. The evaluation of a new molecular entity's (NME's) drug-drug interaction potential is an integral part of risk assessment during drug development and regulatory review. Alteration of activities of enzymes or transporters involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by concomitant drugs may alter drug exposure, which can impact response (safety or efficacy). The recent Food and Drug Administration (FDA) draft drug interaction guidance ( (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072101.pdf)) highlights the methodologies and criteria that may be used to guide drug interaction evaluation by industry and regulatory agencies and to construct informative labeling for health practitioner and patients. In addition, the Food and Drug Administration established a 'Drug Development and Drug Interactions' website to provide up-to-date information regarding evaluation of drug interactions ( (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm080499.htm)). This review summarizes key elements in the FDA drug interaction guidance and new scientific developments that can guide the evaluation of drug-drug interactions during the drug development process.

  8. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    can give rise to chromosome breaks, which in turn can lead to genome instabilities and cell death. The topo II enzyme performs this unraveling for DNA in the cell. Antibacterial...

  9. Sandia, UCLA develop screening libraries to discover drug targets...

    National Nuclear Security Administration (NNSA)

    As headlines highlight the threat of viruses like Ebola and Zika, researchers at Sandia National Laboratories and the University of California Los Angeles (UCLA) have teamed up to ...

  10. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, Roy J.

    1986-01-01

    A polarized internal target apparatus with a polarized gas target of improved polarization and density achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms.

  11. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, R.J.

    1984-10-10

    A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

  12. Electrically charged targets

    DOE Patents [OSTI]

    Goodman, Ronald K.; Hunt, Angus L.

    1984-01-01

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  13. Key Actions for Optimizing for KNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Actions for Optimizing for KNL Key Actions for Optimizing for KNL This webinar consisted of a presentation by Nathan Wichmann of Cray entitled, "Key Actions When Optimizing for KNL." Nathan is a Principal Performance Engineer responsible for tackling performance problems at Cray for many years and he is our contact for the NERSC/Cray Cori Applications Center of Excellence. Nathan's presentation results, in part, from his participation in several "brainstorming" telecons

  14. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in ... diseases affecting the brain and its ability to make new connections and recall memories. ...

  15. Schedules of Key Environmental Impact Statements

    Broader source: Energy.gov [DOE]

    This document graphically displays the milestone dates and projected schedules of key Environmental Impact Statements (updated monthly). This chart represents anticipated activity and is not a...

  16. Florida Keys Electric Cooperative- Residential Rebate Program

    Broader source: Energy.gov [DOE]

    Note: The Florida Keys Electric Cooperative rebates were depleted in June of 2015. According to the website, rebates will be offered again dependent upon future funding.

  17. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS researchers have recently discovered a surprising key event in this energy-quenching process. Photoprotection Through Shifting Pigments Through photosynthesis, plants are able...

  18. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases...

  19. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print Tuesday, 23 June 2015 13:00 The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell

  20. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Takeda Advances Diabetes Drug Development at the ALS Print Tuesday, 19 May 2015 12:25 Type 2 diabetes mellitus (T2DM), characterized by abnormally high blood glucose levels, affects hundreds of millions of people worldwide. In the pursuit to better treat this disease, the human receptor protein GPR40 has been identified by pharmaceutical company Takeda as a potential new drug target. To this end, TAK-875 (fasiglifam), a partial agonist of

  1. Magnetically attached sputter targets

    DOE Patents [OSTI]

    Makowiecki, D.M.; McKernan, M.A.

    1994-02-15

    An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

  2. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - Scientific Applications Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Lead ...

  3. High Power Cryogenic Targets

    SciTech Connect (OSTI)

    Gregory Smith

    2011-08-01

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  4. Captured key electrical safety lockout system

    DOE Patents [OSTI]

    Darimont, Daniel E. (Aurora, IL)

    1995-01-01

    A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member's second position corresponds to the preselected position at which the key can be removed from and inserted into the lock.

  5. Captured key electrical safety lockout system

    DOE Patents [OSTI]

    Darimont, D.E.

    1995-10-31

    A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member`s second position corresponds to the preselected position at which the key can be removed from and inserted into the lock. 7 figs.

  6. PARKING KEY: State Handicap Medically Permitted

    National Nuclear Security Administration (NNSA)

    PARKING KEY: State Handicap Medically Permitted Preferred (LEED) Visitor Motorcycle New Parking Spots / Parallel Parking NATIONAL SECURITY CAMPUS The DOE's National Security Campus is managed and operated by Honeywell. REVISED: August 2014

  7. Explosives performance key to stockpile stewardship

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Explosives performance key to stockpile stewardship Explosives performance key to stockpile stewardship A new video shows how researchers use scientific guns to induce shock waves into explosive materials to study their performance and properties. November 3, 2014 Adam Pacheco of shock and detonation physics presses the "fire" button during an experiment at the two-stage gas gun facility. Adam Pacheco of shock and detonation physics presses the "fire" button during an

  8. Understanding the Key to Henipavirus Infection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Understanding the Key to Henipavirus Infection Understanding the Key to Henipavirus Infection Print Wednesday, 15 June 2016 00:00 In 1994, a virus emerged in Hendra, Australia, causing respiratory and neurological diseases. It was transmissible from horses to humans, with a mortality rate of 57% in humans and 89% in horses. In 1999, a similar virus, transmitted through domesticated pigs, caused over 100 human deaths in Sungai Nipah, a Malaysian village. The Hendra and Nipah viruses are

  9. Explosives performance key to stockpile stewardship

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Explosives performance key to stockpile stewardship Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Explosives performance key to stockpile stewardship A new video shows how researchers use scientific guns to induce shock waves into explosive materials to study their performance and properties January 1, 2015 Adam Pacheco of shock and detonation physics presses the "fire" button during an experiment at the

  10. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Brain Receptor Structures Key to Future Therapeutics Print Wednesday, 28 January 2015 00:00 With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function.

  11. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Print Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS researchers have recently discovered a surprising key event in this energy-quenching

  12. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Print Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS researchers have recently discovered a surprising key event in this energy-quenching

  13. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Print Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS researchers have recently discovered a surprising key event in this energy-quenching

  14. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Carotenoid Pigment is the Key to Photoprotection Print Wednesday, 30 September 2015 00:00 Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS

  15. 'Thirsty' Metals Key to Longer Battery Lifetimes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    'Thirsty' Metals Key to Longer Battery Lifetimes 'Thirsty' Metals Key to Longer Battery Lifetimes Computations at NERSC show how multiply charged metal ions impact battery capacity June 30, 2014 Contact: Kathy Kincade, +1 510 495 2124, kkincade@lbl.gov PCCPxantheascover Imagine a cell phone battery that lasted a whole week on a single charge. A car battery that worked for months between charges. A massive battery that stores the intermittent electricity from wind turbines and releases it when

  16. Carotenoid Pigment is the Key to Photoprotection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carotenoid Pigment is the Key to Photoprotection Print Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be damaging to artificial photosynthetic systems. Nature has solved the problem through a photoprotective mechanism called "nonphotochemical quenching," in which excess solar energy is safely dissipated as heat. ALS researchers have recently discovered a surprising key event in this energy-quenching

  17. Light Sources Help Discover New Drug Against Melanoma | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma July 18, 2011 - 12:07pm Addthis The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four

  18. TEC Working Group Topic Groups Rail Key Documents | Department...

    Office of Environmental Management (EM)

    Rail Key Documents TEC Working Group Topic Groups Rail Key Documents KEY DOCUMENTS Radiation Monitoring Subgroup Intermodal Subgroup Planning Subgroup Current FRA State Rail Safety ...

  19. TEC Working Group Topic Groups Section 180(c) Key Documents ...

    Office of Environmental Management (EM)

    Key Documents TEC Working Group Topic Groups Section 180(c) Key Documents Key Documents Briefing Package for Section 180(c) Implementation - July 2005 PDF icon Executive Summary...

  20. Key Activities in Energy Efficiency | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    About Key Activities in Energy Efficiency Key Activities in Energy Efficiency The Building Technologies Office conducts work in three key areas in order to continually develop ...

  1. 2015 Key Water Power Program and National Laboratory Accomplishments...

    Energy Savers [EERE]

    2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power ...

  2. Bar coded retroreflective target

    DOE Patents [OSTI]

    Vann, Charles S.

    2000-01-01

    This small, inexpensive, non-contact laser sensor can detect the location of a retroreflective target in a relatively large volume and up to six degrees of position. The tracker's laser beam is formed into a plane of light which is swept across the space of interest. When the beam illuminates the retroreflector, some of the light returns to the tracker. The intensity, angle, and time of the return beam is measured to calculate the three dimensional location of the target. With three retroreflectors on the target, the locations of three points on the target are measured, enabling the calculation of all six degrees of target position. Until now, devices for three-dimensional tracking of objects in a large volume have been heavy, large, and very expensive. Because of the simplicity and unique characteristics of this tracker, it is capable of three-dimensional tracking of one to several objects in a large volume, yet it is compact, light-weight, and relatively inexpensive. Alternatively, a tracker produces a diverging laser beam which is directed towards a fixed position, and senses when a retroreflective target enters the fixed field of view. An optically bar coded target can be read by the tracker to provide information about the target. The target can be formed of a ball lens with a bar code on one end. As the target moves through the field, the ball lens causes the laser beam to scan across the bar code.

  3. HYDROGEN ISOTOPE TARGETS

    DOE Patents [OSTI]

    Ashley, R.W.

    1958-08-12

    The design of targets for use in the investigation of nuclear reactions of hydrogen isotopes by bombardment with accelerated particles is described. The target con struction eomprises a backing disc of a metal selected from the group consisting of molybdenunn and tungsten, a eoating of condensed titaniunn on the dise, and a hydrogen isotope selected from the group consisting of deuterium and tritium absorbed in the coatiag. The proeess for preparing these hydrogen isotope targets is described.

  4. Cellulosic Ethanol Cost Target

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Plenary Talk May 21, 2013 Cellulosic Ethanol Cost Target 2 | Biomass Program ... "Our goal is to make cellulosic ethanol practical and cost competitive within 6 ...

  5. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Target 2 Target 2 is housed in the Blue Room in MPF-7 at LANSCE and provides experimenters direct access to the LANSCE proton beam. The Blue Room is a domed room with a diameter of 40 feet. The main floor of the Blue Room is constructed primarily of aluminum and elevated 20 feet above the basement floor to minimize neutron wall return for

  6. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R.; Campbell, Heather L.; Da Silva, Luiz

    2002-01-01

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  7. Public key infrastructure for DOE security research

    SciTech Connect (OSTI)

    Aiken, R.; Foster, I.; Johnston, W.E.

    1997-06-01

    This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

  8. NIF Target Shot Metrics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    target shot metrics NIF Target Shot Metrics Exp Cap - Experimental Capability Natl Sec Appl - National Security Applications DS - Discovery Science ICF - Inertial Confinement Fusion HED - High Energy Density For internal LLNL firewall viewing - if the page is blank, please open www.google.com to flush out BCB

  9. Rab proteins: The key regulators of intracellular vesicle transport

    SciTech Connect (OSTI)

    Bhuin, Tanmay; Roy, Jagat Kumar

    2014-10-15

    Vesicular/membrane trafficking essentially regulates the compartmentalization and abundance of proteins within the cells and contributes in many signalling pathways. This membrane transport in eukaryotic cells is a complex process regulated by a large and diverse array of proteins. A large group of monomeric small GTPases; the Rabs are essential components of this membrane trafficking route. Most of the Rabs are ubiquitously expressed proteins and have been implicated in vesicle formation, vesicle motility/delivery along cytoskeleton elements and docking/fusion at target membranes through the recruitment of effectors. Functional impairments of Rabs affecting transport pathways manifest different diseases. Rab functions are accompanied by cyclical activation and inactivation of GTP-bound and GDP-bound forms between the cytosol and membranes which is regulated by upstream regulators. Rab proteins are characterized by their distinct sub-cellular localization and regulate a wide variety of endocytic, transcytic and exocytic transport pathways. Mutations of Rabs affect cell growth, motility and other biological processes. - Highlights: Rab proteins regulate different signalling pathways. Deregulation of Rabs is the fundamental causes of a variety of human diseases. This paper gives potential directions in developing therapeutic targets. This paper also gives ample directions for modulating pathways central to normal physiology. These are the huge challenges for drug discovery and delivery in near future.

  10. Key Management Challenges in Smart Grid

    SciTech Connect (OSTI)

    Sheldon, Frederick T; Duren, Mike

    2012-01-01

    Agenda Awarded in February 2011 Team of industry and research organizations Project Objectives Address difficult issues Complexity Diversity of systems Scale Longevity of solution Participate in standards efforts and working groups Develop innovative key management solutions Modeling and simulation ORNL Cyber Security Econometric Enterprise System Demonstrate effectiveness of solution Demonstrate scalability

  11. Automated Proactive Fault Isolation: A Key to Automated Commissioning

    SciTech Connect (OSTI)

    Katipamula, Srinivas; Brambley, Michael R.

    2007-07-31

    In this paper, we present a generic model for automated continuous commissioing and then delve in detail into one of the processes, proactive testing for fault isolation, which is key to automating commissioning. The automated commissioining process uses passive observation-based fault detction and diagnostic techniques, followed by automated proactive testing for fault isolation, automated fault evaluation, and automated reconfiguration of controls together to continuously keep equipment controlled and running as intended. Only when hard failures occur or a physical replacement is required does the process require human intervention, and then sufficient information is provided by the automated commissioning system to target manual maintenance where it is needed. We then focus on fault isolation by presenting detailed logic that can be used to automatically isolate faults in valves, a common component in HVAC systems, as an example of how automated proactive fault isolation can be accomplished. We conclude the paper with a discussion of how this approach to isolating faults can be applied to other common HVAC components and their automated commmissioning and a summary of key conclusions of the paper.

  12. An Unusual Mechanism for the Antimicrobial Target Flavine-dependant

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Thymidylate Synthase (FTDS) An Unusual Mechanism for the Antimicrobial Target Flavine-dependant Thymidylate Synthase (FTDS) Classical thymidylate synthases, encoded by the thyA and TYMS genes, are present in most eukaryotes, including humans, and are frequently targeted by chemotherapeutic and antibiotic drugs. A recently discovered class of thymidylate synthases, the FDTSs encoded by the thyX gene has been found primarily in prokaryotes and viruses including several pathogens and biological

  13. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

    SciTech Connect (OSTI)

    Hast, Michael A.; Nichols, Connie B.; Armstrong, Stephanie M.; Kelly, Shannon M.; Hellinga, Homme W.; Alspaugh, J. Andrew; Beese, Lorena S.

    2012-09-17

    Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals, including AIDS patients and transplant recipients. Few antifungals can treat C. neoformans infections, and drug resistance is increasing. Protein farnesyltransferase (FTase) catalyzes post-translational lipidation of key signal transduction proteins and is essential in C. neoformans. We present a multidisciplinary study validating C. neoformans FTase (CnFTase) as a drug target, showing that several anticancer FTase inhibitors with disparate scaffolds can inhibit C. neoformans and suggesting structure-based strategies for further optimization of these leads. Structural studies are an essential element for species-specific inhibitor development strategies by revealing similarities and differences between pathogen and host orthologs that can be exploited. We, therefore, present eight crystal structures of CnFTase that define the enzymatic reaction cycle, basis of ligand selection, and structurally divergent regions of the active site. Crystal structures of clinically important anticancer FTase inhibitors in complex with CnFTase reveal opportunities for optimization of selectivity for the fungal enzyme by modifying functional groups that interact with structurally diverse regions. A substrate-induced conformational change in CnFTase is observed as part of the reaction cycle, a feature that is mechanistically distinct from human FTase. Our combined structural and functional studies provide a framework for developing FTase inhibitors to treat invasive fungal infections.

  14. Multiple shell fusion targets

    DOE Patents [OSTI]

    Lindl, J.D.; Bangerter, R.O.

    1975-10-31

    Multiple shell fusion targets for use with electron beam and ion beam implosion systems are described. The multiple shell targets are of the low-power type and use a separate relatively low Z, low density ablator at large radius for the outer shell, which reduces the focusing and power requirements of the implosion system while maintaining reasonable aspect ratios. The targets use a high Z, high density pusher shell placed at a much smaller radius in order to obtain an aspect ratio small enough to protect against fluid instability. Velocity multiplication between these shells further lowers the power requirements. Careful tuning of the power profile and intershell density results in a low entropy implosion which allows breakeven at low powers. For example, with ion beams as a power source, breakeven at 10-20 Terrawatts with 10 MeV alpha particles for imploding a multiple shell target can be accomplished.

  15. Diversity and Flexibility: Key to Sustainability

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Babson, Ph.D. Senior Engineer Union of Concerned Scientists Diversity & Flexibility Key to Sustainability Biofuels Pathways are Diverse * General perception of biofuels are limited to corn ethanol and soybean biodiesel Biofuels Pathways are Diverse * General perception of biofuels are limited to corn ethanol and soybean biodiesel * Biofuels are important and they are so much more than corn ethanol and soybean biodiesel Biofuels Pathways are Diverse * General perception of biofuels are

  16. Milling of key slots on long shafts

    SciTech Connect (OSTI)

    Agadzhanyan, R.A.; Bogdanenko, Yu.G.

    1987-03-01

    The authors look for and test methods and tool materials for milling key slots into rod pump shafts made of steel-03KH14N7V and K Monel alloy which not only increase the precision of the milling process but also extend the life of the milling tool. Their test parameters include various methods for introduction of the cutting fluid into the milling process, the effect of carbonitridation of the tool material, and the productivity of the machine itself.

  17. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function. These molecules transmit signals between nerve cells and are critical to learning and

  18. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function. These molecules transmit signals between nerve cells and are critical to learning and

  19. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function. These molecules transmit signals between nerve cells and are critical to learning and

  20. Key Physical Mechanisms in Nanostructured Solar Cells

    SciTech Connect (OSTI)

    Dr Stephan Bremner

    2010-07-21

    The objective of the project was to study both theoretically and experimentally the excitation, recombination and transport properties required for nanostructured solar cells to deliver energy conversion efficiencies well in excess of conventional limits. These objectives were met by concentrating on three key areas, namely, investigation of physical mechanisms present in nanostructured solar cells, characterization of loss mechanisms in nanostructured solar cells and determining the properties required of nanostructured solar cells in order to achieve high efficiency and the design implications.

  1. Identification of Key Barriers in Workforce Development

    SciTech Connect (OSTI)

    2008-03-31

    This report documents the identification of key barriers in the development of an adequate national security workforce as part of the National Security Preparedness Project, being performed under a Department of Energy/National Nuclear Security Administration grant. Many barriers exist that prevent the development of an adequate number of propertly trained national security personnel. Some barriers can be eliminated in a short-term manner, whereas others will involve a long-term strategy that takes into account public policy.

  2. Key Issues in Tribal Energy Development

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Issues in Tribal Energy Development Common Issues, Causes and Solutions Douglas C. MacCourt, Ater Wynne LLP Chair Chair, Executive Committee Indian Law Practice Group Indian Law Section Ater Wynne LLP Oregon State Bar Association dcm@aterwynne.com www.aterwynne.com US DOE Tribal Energy Program/NREL Denver, Colorado October 25-28, 2010 Overview of Presentation * Overview of Handbook * A note on Alaska * Common development issues and solutions 1. Finding Early Stage Risk Capital * Necessary

  3. Key Renewable Energy Opportunities for Oklahoma Tribes

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    KEY RENEWABLE ENERGY OPPORTUNITIES FOR OKLAHOMA TRIBES August 13, 2012 COX CONVENTION CENTER 100 West Sheridan Avenue, Oklahoma City, OK 73102 (405) 602-8500 The fifth in a series of planned U.S. DOE Office of Indian Energy-sponsored strategic energy development & investment forums, this forum is designed to give Oklahoma tribal leaders the opportunity to receive the latest updates on DOE's energy development efforts in Indian Country. The Forum will provide a venue for tribal leaders to

  4. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases affecting the brain and its ability to make new connections and recall memories. Some of the most important players in the brain's normal function are the glutamate receptors, which are involved in nervous-system development and function. These molecules transmit signals between nerve cells and are critical to learning and

  5. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Print Type 2 diabetes mellitus (T2DM), characterized by abnormally high blood glucose levels, affects hundreds of millions of people worldwide. In the pursuit to better treat this disease, the human receptor protein GPR40 has been identified by pharmaceutical company Takeda as a potential new drug target. To this end, TAK-875 (fasiglifam), a partial agonist of GPR40, was brought into clinical development by Takeda as a possible new treatment

  6. Computer modeling reveals how surprisingly potent hepatitis C drug works

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy

  7. New Security Results on Encrypted Key Exchange

    SciTech Connect (OSTI)

    Bresson, Emmanuel; Chevassut, Olivier; Pointcheval, David

    2003-12-15

    Schemes for encrypted key exchange are designed to provide two entities communicating over a public network, and sharing a (short) password only, with a session key to be used to achieve data integrity and/or message confidentiality. An example of a very efficient and ''elegant'' scheme for encrypted key exchange considered for standardization by the IEEE P1363 Standard working group is AuthA. This scheme was conjectured secure when the symmetric-encryption primitive is instantiated via either a cipher that closely behaves like an ''ideal cipher,'' or a mask generation function that is the product of the message with a hash of the password. While the security of this scheme in the former case has been recently proven, the latter case was still an open problem. For the first time we prove in this paper that this scheme is secure under the assumptions that the hash function closely behaves like a random oracle and that the computational Diffie-Hellman problem is difficult. Furthermore, since Denial-of-Service (DoS) attacks have become a common threat we enhance AuthA with a mechanism to protect against them.

  8. Drug Detection Study

    Office of Scientific and Technical Information (OSTI)

    ... cause a person to be identified as using that substance in a workplace drug test. The initial test refers to the screening assay on specimens to eliminate a "negative" result ...

  9. Drug Testing Notification | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Drug Testing Notification Drug Testing Notification PDF icon Drug Testing Notification More Documents & Publications Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, ...

  10. The Sinuous Target

    SciTech Connect (OSTI)

    Zwaska, R.

    2015-06-01

    We report on the concept for a target material comprised of a multitude of interlaced wires of small dimension. This target material concept is primarily directed at high-power neutrino targets where the thermal shock is large due to small beam sizes and short durations; it also has applications to other high-power targets, particularly where the energy deposition is great or a high surface area is preferred. This approach ameliorates the problem of thermal shock by engineering a material with high strength on the micro-scale, but a very low modulus of elasticity on the meso-scale. The low modulus of elasticity is achieved by constructing the material of spring-like wire segments much smaller than the beam dimension. The intrinsic bends of the wires will allow them to absorb the strain of thermal shock with minimal stress. Furthermore, the interlaced nature of the wires provides containment of any segment that might become loose. We will discuss the progress on studies of analogue materials and fabrication techniques for sinuous target materials.

  11. Production Target Design Report

    SciTech Connect (OSTI)

    Woloshun, Keith Albert; Dale, Gregory E.; Olivas, Eric Richard

    2015-07-28

    The Northstar 99Mo production target, a cylindrical length of 100Mo rod, has evolved considerably since its first conception.  The cylinder was very early sliced into disks to increase the heat transfer area, first to 1 mm thick disks then to the current 0.5 mm thick.  The coolant was changed early in the target development from water to helium to eliminate corrosion and dissolution.  The diameter has increased from initially 6 mm to 12 mm, the current diameter of the test target now at ANL, to nominally 28 mm (26-30.6 mm, depending upon optimal beam spot size and shape).  The length has also changed to improve the production to cost ratio, so now the target is nominally 41 mm long (excluding coolant gaps between disks), and irradiated on both ends.  This report summarizes the current status of the plant target design.

  12. CONSTRUCTION OF KEY CLEANUP PROJECT GAINS GOOD GROUND AT SRS...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    CONSTRUCTION OF KEY CLEANUP PROJECT GAINS GOOD GROUND AT SRS CONSTRUCTION OF KEY CLEANUP PROJECT GAINS GOOD GROUND AT SRS June 1, 2010 - 12:00pm Addthis CONSTRUCTION OF KEY CLEANUP ...

  13. Method for encryption and transmission of digital keying data

    DOE Patents [OSTI]

    Mniszewski, Susan M.; Springer, Edward A.; Brenner, David P.

    1988-01-01

    A method for the encryption, transmission, and subsequent decryption of digital keying data. The method utilizes the Data Encryption Standard and is implemented by means of a pair of apparatus, each of which is selectable to operate as either a master unit or remote unit. Each unit contains a set of key encryption keys which are indexed by a common indexing system. The master unit operates upon command from the remote unit to generate a data encryption key and encrypt the data encryption key using a preselected key encryption key. The encrypted data encryption key and an index designator are then downloaded to the remote unit, where the data encryption key is decrypted for subsequent use in the encryption and transmission data. Downloading of the encrypted data encryption key enables frequent change of keys without requiring manual entry or storage of keys at the remote unit.

  14. Fermilab | Science | Particle Physics | Key Discoveries

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Discoveries Fermilab produced its first high-energy particle beam on March 1, 1972. Since then hundreds of experiments have used Fermilab's accelerators to study matter at ever smaller scales and its detectors to study the universe at great distances. Here an overview of the top achievements so far. Discovery of the Higgs boson Discovery of the top quark Discovery of the bottom quark Observation of tau neutrino Discovery of a quasar at a distance of 27 billion light-years Observation of

  15. Cryptographic Key Management and Critical Risk Assessment

    SciTech Connect (OSTI)

    Abercrombie, Robert K

    2014-05-01

    The Department of Energy Office of Electricity Delivery and Energy Reliability (DOE-OE) CyberSecurity for Energy Delivery Systems (CSEDS) industry led program (DE-FOA-0000359) entitled "Innovation for Increasing CyberSecurity for Energy Delivery Systems (12CSEDS)," awarded a contract to Sypris Electronics LLC to develop a Cryptographic Key Management System for the smart grid (Scalable Key Management Solutions for Critical Infrastructure Protection). Oak Ridge National Laboratory (ORNL) and Sypris Electronics, LLC as a result of that award entered into a CRADA (NFE-11-03562) between ORNL and Sypris Electronics, LLC. ORNL provided its Cyber Security Econometrics System (CSES) as a tool to be modified and used as a metric to address risks and vulnerabilities in the management of cryptographic keys within the Advanced Metering Infrastructure (AMI) domain of the electric sector. ORNL concentrated our analysis on the AMI domain of which the National Electric Sector Cyber security Organization Resource (NESCOR) Working Group 1 (WG1) has documented 29 failure scenarios. The computational infrastructure of this metric involves system stakeholders, security requirements, system components and security threats. To compute this metric, we estimated the stakes that each stakeholder associates with each security requirement, as well as stochastic matrices that represent the probability of a threat to cause a component failure and the probability of a component failure to cause a security requirement violation. We applied this model to estimate the security of the AMI, by leveraging the recently established National Institute of Standards and Technology Interagency Report (NISTIR) 7628 guidelines for smart grid security and the International Electrotechnical Commission (IEC) 63351, Part 9 to identify the life cycle for cryptographic key management, resulting in a vector that assigned to each stakeholder an estimate of their average loss in terms of dollars per day of system

  16. Preliminary safety assessment for an IFE target fabrication facility

    SciTech Connect (OSTI)

    Latkowski, J F; Reyes, S; Besenbruch, G E; Goodin, D T

    2000-10-13

    We estimate possible ranges of tritium inventories for an inertial fusion energy (IFE) target fabrication facility producing various types of targets and using various production technologies. Target fill is the key subtask in determining the overall tritium inventory for the plant. By segmenting the inventory into multiple, parallel production lines--each with its own fill canister--and including an expansion tank to limit releases, we are able to ensure that a target fabrication facility would meet the accident dose goals of 10 mSv (1 rem) set forth in the Department of Energy's Fusion Safety Standards. For indirect-drive targets, we calculate release fractions for elements from lithium to bismuth and show that nearly all elements meet the dose goal. Our work suggests directions for future R&D that will help reduce total tritium inventories and increase the flexibility of target fabrication facilities.

  17. Cooled particle accelerator target

    DOE Patents [OSTI]

    Degtiarenko, Pavel V.

    2005-06-14

    A novel particle beam target comprising: a rotating target disc mounted on a retainer and thermally coupled to a first array of spaced-apart parallel plate fins that extend radially inwardly from the retainer and mesh without physical contact with a second array of spaced-apart parallel plate fins that extend radially outwardly from and are thermally coupled to a cooling mechanism capable of removing heat from said second array of spaced-apart fins and located within the first array of spaced-apart parallel fins. Radiant thermal exchange between the two arrays of parallel plate fins provides removal of heat from the rotating disc. A method of cooling the rotating target is also described.

  18. Cooling Towers: Understanding Key Components of Cooling Towers...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve Water Efficiency Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve ...

  19. Keys to Successful Quality Assurance and Quality Control Programs...

    Office of Environmental Management (EM)

    Keys to Successful Quality Assurance and Quality Control Programs (101) Keys to Successful Quality Assurance and Quality Control Programs (101) January 28...

  20. Focus Series: Program Finds Community "Readiness" Is the Key...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Program Finds Community "Readiness" Is the Key to More Retrofits Focus Series: Program Finds Community "Readiness" Is the Key to More Retrofits Focus Series: Program Finds ...

  1. Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. ...

  2. Physicists in China Nail a Key Neutrino Measurement (Science...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in China Nail a Key Neutrino Measurement (Science) External Link: http:news.sciencemag.orgsciencenow201203physicists-in-china-nail-a-key.htm... By jlabadmin on Thu, ...

  3. Building America Expert Meeting: Key Innovations for Adding Energy...

    Energy Savers [EERE]

    Key Innovations for Adding Energy Efficiency to Maintenance Projects Building America Expert Meeting: Key Innovations for Adding Energy Efficiency to Maintenance Projects This ...

  4. Self-Referenced Continuous-Variable Quantum Key Distribution...

    Office of Scientific and Technical Information (OSTI)

    Self-Referenced Continuous-Variable Quantum Key Distribution Protocol Citation Details In-Document Search Title: Self-Referenced Continuous-Variable Quantum Key Distribution ...

  5. Keys to Successful Quality Assurance and Quality Control Programs...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Keys to Successful Quality Assurance and Quality Control Programs (101) Keys to Successful Quality Assurance and Quality Control Programs (101) Better Buildings Residential Network ...

  6. Spotlight on Key Program Strategies from the Better Buildings...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Spotlight on Key Program Strategies from the Better Buildings Neighborhood Program, Final Evaluation Volume 6 Spotlight on Key Program Strategies from the Better Buildings Neighborhood ...

  7. Key Renewable Energy Opportunities for Oklahoma Tribes | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Renewable Energy Opportunities for Oklahoma Tribes Key Renewable Energy Opportunities for Oklahoma Tribes August 13, 2012 Oklahoma City, Oklahoma Cox Convention Center The...

  8. Turbulence may be key to "fast magnetic reconnection" mystery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Turbulence may be key to "fast magnetic reconnection" mystery Turbulence may be key to "fast magnetic reconnection" mystery The new research could lead to better understanding of ...

  9. Energy: Critical Infrastructure and Key Resources Sector-Specific...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy: Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) Energy: Critical Infrastructure and Key ...

  10. Energy Critical Infrastructure and Key Resources Sector-Specific...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) Energy Critical Infrastructure and Key ...

  11. 2015 Key Water Power Program and National Laboratory Accomplishments...

    Broader source: Energy.gov (indexed) [DOE]

    Water Power Program and National Laboratory Accomplishments 2015 Key Water Power Program and National Laboratory Accomplishments | 1 | 2015 Key Water Power Program and National ...

  12. PEM Fuel Cell Technology, Key Research Needs and Approaches ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Technology, Key Research Needs and Approaches (Presentation) PEM Fuel Cell Technology, Key Research Needs and Approaches (Presentation) Presented at the DOE Fuel Cell ...

  13. Together with Key Allies, DOE Launches New Data Collaborative...

    Energy Savers [EERE]

    Together with Key Allies, DOE Launches New Data Collaborative to Help Cities and States Advance Building Efficiency Together with Key Allies, DOE Launches New Data Collaborative to ...

  14. Foam encapsulated targets

    DOE Patents [OSTI]

    Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

    1983-01-01

    Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

  15. Targeted polypeptide degradation

    DOE Patents [OSTI]

    Church, George M.; Janse, Daniel M.

    2008-05-13

    This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

  16. Targeted radionuclide therapy

    SciTech Connect (OSTI)

    Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F.

    2008-07-15

    Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

  17. Low-Power Public Key Cryptography

    SciTech Connect (OSTI)

    BEAVER,CHERYL L.; DRAELOS,TIMOTHY J.; HAMILTON,VICTORIA A.; SCHROEPPEL,RICHARD C.; GONZALES,RITA A.; MILLER,RUSSELL D.; THOMAS,EDWARD V.

    2000-11-01

    This report presents research on public key, digital signature algorithms for cryptographic authentication in low-powered, low-computation environments. We assessed algorithms for suitability based on their signature size, and computation and storage requirements. We evaluated a variety of general purpose and special purpose computing platforms to address issues such as memory, voltage requirements, and special functionality for low-powered applications. In addition, we examined custom design platforms. We found that a custom design offers the most flexibility and can be optimized for specific algorithms. Furthermore, the entire platform can exist on a single Application Specific Integrated Circuit (ASIC) or can be integrated with commercially available components to produce the desired computing platform.

  18. SECTION L -ATTACHMENT B - LISTING OF KEY PERSONNEL

    National Nuclear Security Administration (NNSA)

    H SECTION J APPENDIX H KEY PERSONNEL [Note: To be inserted by the Contracting Officer after

  19. Drug development and manufacturing

    DOE Patents [OSTI]

    Warner, Benjamin P.; McCleskey, T. Mark; Burrell, Anthony K.

    2015-10-13

    X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.

  20. Climate Action Planning: A Review of Best Practices, Key Elements...

    Open Energy Info (EERE)

    a climate action plan. The report includes detailed discussion of stakeholder involvement, establishing a target date and interim targets for achieving climate neutrality,...

  1. NASA agreements advance Mars exploration, Los Alamos Rover instrument a key

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    component NASA agreements advance Mars exploration NASA agreements advance Mars exploration, Los Alamos Rover instrument a key component Los Alamos National Laboratory is coordinating with the French science and engineering team on developing SuperCam. June 17, 2015 SuperCam builds upon the successful capabilities demonstrated by ChemCam aboard the Curiosity Rover during NASA's current Mars Mission. SuperCam will allow researchers to sample rocks and other targets from a distance using a

  2. Solvent recovery targeting

    SciTech Connect (OSTI)

    Ahmad, B.S.; Barton, P.I.

    1999-02-01

    One of the environmental challenges faced by the pharmaceutical and specialty chemical industries is the widespread use of organic solvents. With a solvent-based chemistry, the solvent necessarily has to be separated from the product. Chemical species in waste-solvent streams typically form multicomponent azeotropic mixtures, and this often complicates separation and, hence, recovery of solvents. A design approach is presented whereby process modifications proposed by the engineer to reduce the formation of waste-solvent streams can be evaluated systematically. This approach, called solvent recovery targeting, exploits a recently developed algorithm for elucidating the separation alternatives achievable when applying batch distillation to homogeneous multicomponent mixtures. The approach places the composition of the waste-solvent mixture correctly in the relevant residue curve map and computes the maximum amount of pure material that can be recovered via batch distillation. Solvent recovery targeting is applied to two case studies derived from real industrial processes.

  3. Method for forming targets

    DOE Patents [OSTI]

    Woerner, Robert L.

    1979-01-01

    Method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

  4. Apparatus for forming targets

    DOE Patents [OSTI]

    Woerner, Robert L.

    1980-01-01

    Apparatus and method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

  5. Key management for large scale end-to-end encryption

    SciTech Connect (OSTI)

    Witzke, E.L.

    1994-07-01

    Symmetric end-to-end encryption requires separate keys for each pair of communicating confidants. This is a problem of Order N{sup 2}. Other factors, such as multiple sessions per pair of confidants and multiple encryption points in the ISO Reference Model complicate key management by linear factors. Public-key encryption can reduce the number of keys managed to a linear problem which is good for scaleability of key management, but comes with complicating issues and performance penalties. Authenticity is the primary ingredient of key management. If each potential pair of communicating confidants can authenticate data from each other, then any number of public encryption keys of any type can be communicated with requisite integrity. These public encryption keys can be used with the corresponding private keys to exchange symmetric cryptovariables for high data rate privacy protection. The Digital Signature Standard (DSS), which has been adopted by the United States Government, has both public and private components, similar to a public-key cryptosystem. The Digital Signature Algorithm of the DSS is intended for authenticity but not for secrecy. In this paper, the authors will show how the use of the Digital Signature Algorithm combined with both symmetric and asymmetric (public-key) encryption techniques can provide a practical solution to key management scaleability problems, by reducing the key management complexity to a problem of order N, without sacrificing the encryption speed necessary to operate in high performance networks.

  6. Florida Keys El Coop Assn, Inc | Open Energy Information

    Open Energy Info (EERE)

    Keys El Coop Assn, Inc Jump to: navigation, search Name: Florida Keys El Coop Assn, Inc Place: Florida Phone Number: 305-852-2431 Website: www.fkec.com Twitter: @FLKeysElectric...

  7. Solid Electrolyte: the Key for High-Voltage Lithium Batteries...

    Office of Scientific and Technical Information (OSTI)

    Solid Electrolyte: the Key for High-Voltage Lithium Batteries Citation Details In-Document Search Title: Solid Electrolyte: the Key for High-Voltage Lithium Batteries Authors: Li, ...

  8. Key Dates | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Key Dates DOE Office of Science Graduate Student Research (SCGSR) Program SCGSR Home Eligibility Benefits Participant Obligations How to Apply Information for Laboratory Scientists and Thesis Advisors Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A FeedbackShare Page The SCGSR Program Key Dates are noted below. At the submission deadline (shown in red), the online application system will close after which no additional materials will be accepted. The

  9. June2010KeyEISChart.pdf | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    June2010KeyEISChart.pdf June2010KeyEISChart.pdf June2010KeyEISChart.pdf (59.25 KB) More Documents & Publications Schedules of Key Environmental Impact Statements Demonstration of a Variable Phase Turbine Power System for Low Temperature Geothermal Resources A 3D-3C Reflection Seismic Survey and Data Integration to Identify the Seismic Response of Fractures and Permeable Zones Over a Known Geothermal Resource at Soda Lake, Churchhill Co., NV

  10. Residential Energy Efficiency Financing: Key Elements of Program Design

    Broader source: Energy.gov [DOE]

    Presents key programmatic elements and context of financing initiatives, including contractor support, rebates, quality assurance, and more.

  11. SECTION L -ATTACHMENT B - LISTING OF KEY PERSONNEL

    National Nuclear Security Administration (NNSA)

    B, Page 1 SECTION L ATTACHMENT B LISTING OF KEY PERSONNEL TITLE NAME Note: Addremove extra rows if needed...

  12. 2015 Key Water Power Program and National Laboratory Accomplishments

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Slideshow | Department of Energy 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power Program and National Laboratory Accomplishments Report 1 of 28 2015 Key Water Power Program and National Laboratory Accomplishments Report By accelerating the development of markets for hydropower and marine and hydrokinetic (MHK) projects, the Water Power Program is striving to

  13. 2015 Key Wind Program and National Laboratory Accomplishments | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 2015 Key Wind Program and National Laboratory Accomplishments 2015 Key Wind Program and National Laboratory Accomplishments 2015 Key Wind Program and National Laboratory Accomplishments 1 of 32 2015 Key Wind Program and National Laboratory Accomplishments The U.S. Department of Energy (DOE) Wind Program is committed to helping the nation secure cost-competitive sources of renewable energy through the development and deployment of innovative wind power technologies. By investing in

  14. Key Dates | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Dates Albert Einstein Distinguished Educator Fellowship (AEF) Program Einstein Fellowship Home Eligibility Benefits Obligations How to Apply Key Dates Frequently Asked Questions Fellows Central Contact WDTS Home Key Dates Print Text Size: A A A FeedbackShare Page Key Dates for the 2017-2018 AEF Program Application process. On-line Application Opens August 17, 2016 Application Deadline 8:00pm EST November 17, 2016 Application Review 8 - 9 weeks Notification to Semi-Finalists [Travel

  15. Key Dates | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Dates DOE Office of Science Graduate Student Research (SCGSR) Program SCGSR Home Eligibility Benefits Participant Obligations How to Apply Information for Laboratory Scientists and Thesis Advisors Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A FeedbackShare Page The SCGSR Program Key Dates are noted below. At the submission deadline (shown in red), the online application system will close after which no additional materials will be accepted. The

  16. 2015 Key Water Power Program and National Laboratory Accomplishments

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Slideshow | Department of Energy 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow 2015 Key Water Power Program and National Laboratory Accomplishments Slideshow Addthis 2015 Key Water Power Program and National Laboratory Accomplishments Report 1 of 28 2015 Key Water Power Program and National Laboratory Accomplishments Report By accelerating the development of markets for hydropower and marine and hydrokinetic (MHK) projects, the Water Power Program is striving

  17. 2015 Key Wind Program and National Laboratory Accomplishments Slideshow |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 2015 Key Wind Program and National Laboratory Accomplishments Slideshow 2015 Key Wind Program and National Laboratory Accomplishments Slideshow Addthis 2015 Key Wind Program and National Laboratory Accomplishments 1 of 32 2015 Key Wind Program and National Laboratory Accomplishments The U.S. Department of Energy (DOE) Wind Program is committed to helping the nation secure cost-competitive sources of renewable energy through the development and deployment of innovative

  18. Fuel Cell Technologies Office Key Activities | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    About the Fuel Cell Technologies Office » Fuel Cell Technologies Office Key Activities Fuel Cell Technologies Office Key Activities The Fuel Cell Technologies Office conducts work in several key areas to advance the development and commercialization of hydrogen and fuel cell technologies. Research, Development, and Demonstration Key areas of research, development, and demonstration (RD&D) include the following: Fuel Cell R&D, which seeks to improve the durability, reduce the cost, and

  19. Target: Subpoena (2010-SE-2001)

    Broader source: Energy.gov [DOE]

    DOE issued a Subpoena for Information and Production of Documents to Target Corporation requesting information regarding the compliance of various torchieres Target has distributed in commerce in the U.S.

  20. Key Activities of the Geothermal Technologies Office | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    About the Geothermal Technologies Office » Key Activities of the Geothermal Technologies Office Key Activities of the Geothermal Technologies Office Key activities for the Geothermal Technologies Office (GTO) include research, development and demonstration; system validation; technology validation; strategic planning, analysis, and R&D integration. Specific activities are summarized below. Program Area Activities Enhanced Geothermal Systems (EGS) GTO conducts research, development and

  1. Target detection portal

    DOE Patents [OSTI]

    Linker, Kevin L.; Brusseau, Charles A.

    2002-01-01

    A portal apparatus for screening persons or objects for the presence of trace amounts of target substances such as explosives, narcotics, radioactive materials, and certain chemical materials. The portal apparatus can have a one-sided exhaust for an exhaust stream, an interior wall configuration with a concave-shape across a horizontal cross-section for each of two facing sides to result in improved airflow and reduced washout relative to a configuration with substantially flat parallel sides; air curtains to reduce washout; ionizing sprays to collect particles bound by static forces, as well as gas jet nozzles to dislodge particles bound by adhesion to the screened person or object. The portal apparatus can be included in a detection system with a preconcentrator and a detector.

  2. Electromagnetic targeting of guns

    SciTech Connect (OSTI)

    Pogue, E.W.; Boat, R.M.; Holden, D.N.; Lopez, J.R.

    1996-10-01

    This is the final report of a one-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Electromagnetic pulse (EMP) signals produced from explosives being fired have been reported in the literature for fifty years. When a gun is fired it produces an EMP muzzle blast signal. The strength and nature of these signals was first analyzed in the early 1970s, while the results were interesting, no follow-up studies were conducted. With modern detection and signal processing technology, we believe that these signals could be used to instantaneously locate guns of virtually all calibers as they fire. The objective of our one-year project was to establish the basic nature of these signals and their utility in the concept of electromagnetic targeting of guns.

  3. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    structural similarities between SalL and flurorinase could lead to new halogenation pathways and more effective drug treatment strategies. Closeup view of SalL's...

  4. Liquid film target impingement scrubber

    DOE Patents [OSTI]

    McDowell, William J.; Coleman, Charles F.

    1977-03-15

    An improved liquid film impingement scrubber is provided wherein particulates suspended in a gas are removed by jetting the particle-containing gas onto a relatively small thin liquid layer impingement target surface. The impingement target is in the form of a porous material which allows a suitable contacting liquid from a pressurized chamber to exude therethrough to form a thin liquid film target surface. The gas-supported particles collected by impingement of the gas on the target are continuously removed and flushed from the system by the liquid flow through each of a number of pores in the target.

  5. Drug Testing for DOE Positions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing Matrix Secretary Bodman's Memorandum Regarding Drug Testing at DOE Fact ...

  6. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hosoya, Hitomi; Dobroff, Andrey S.; Driessen, Wouter H. P.; Cristini, Vittorio; Brinker, Lina M.; Staquicini, Fernanda I.; Cardó-Vila, Marina; D’Angelo, Sara; Ferrara, Fortunato; Proneth, Bettina; et al

    2016-02-02

    A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogel-based nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared,more » thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. We conclude that these results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications.« less

  7. Enterprise Assessments Targeted Review of the Targeted Review...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    assessment, conducted in August 2014, was part of a larger targeted assessment of safety class and safety significant structures, systems, and components across the DOE complex. ...

  8. A key management concept for the CTBT International Monitoring System

    SciTech Connect (OSTI)

    Herrington, P.; Draelos, T.; Craft, R.; Brickell, E.; Frankel, Y.; Silvestri, M.

    1997-08-01

    Cryptographic authentication (commonly referred to as ``technical authentication`` in Working Group B) is an enabling technology which ensures the integrity of sensor data and security of digital networks under various data security compromise scenarios. The use of cryptographic authentication,however, implies the development of a key management infrastructure for establishing trust in the generation and distribution of cryptographic keys. This paper proposes security and operational requirements for a CTBT (Comprehensive Test Ban Treaty) key management system and, furthermore, presents a public key based solution satisfying the requirements. The key management system is instantiated with trust distribution technologies similar to those currently implemented in industrial public key infrastructures. A complete system solution is developed.

  9. National Rotor Testbed Targets Future Wind Plant Research Needs |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Rotor Testbed Targets Future Wind Plant Research Needs National Rotor Testbed Targets Future Wind Plant Research Needs May 18, 2015 - 4:12pm Addthis Two illustrated graphs. The graph on the top shows a single line repeating in four quadrants, the bottom graph shows all colors The U.S. Department of Energy's (DOE's) Atmosphere to Electrons (A2e) initiative has identified the evolution of wakes in turbulent inflow as a key physical process affecting power production and

  10. Facility target insert shielding assessment

    SciTech Connect (OSTI)

    Mocko, Michal

    2015-10-06

    Main objective of this report is to assess the basic shielding requirements for the vertical target insert and retrieval port. We used the baseline design for the vertical target insert in our calculations. The insert sits in the 12”-diameter cylindrical shaft extending from the service alley in the top floor of the facility all the way down to the target location. The target retrieval mechanism is a long rod with the target assembly attached and running the entire length of the vertical shaft. The insert also houses the helium cooling supply and return lines each with 2” diameter. In the present study we focused on calculating the neutron and photon dose rate fields on top of the target insert/retrieval mechanism in the service alley. Additionally, we studied a few prototypical configurations of the shielding layers in the vertical insert as well as on the top.

  11. Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Across U.S. Industry | Department of Energy Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry eip_report_pg9.pdf (2.52 MB) More Documents & Publications ITP Energy Intensive Processes: Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry Energy Technology Solutions Energy Technology Solutions: Public-Private

  12. Key Renewable Energy Opportunities for Oklahoma Tribes | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Key Renewable Energy Opportunities for Oklahoma Tribes Key Renewable Energy Opportunities for Oklahoma Tribes August 13, 2012 Oklahoma City, Oklahoma Cox Convention Center The Office of Indian Energy Tribal Leader Energy Forum on Key Renewable Energy Opportunities for Oklahoma Tribes was held August 13, 2012, in Oklahoma City, Oklahoma. The forum gave Oklahoma tribal leaders the opportunity to receive the latest updates on DOE's energy development efforts in Indian Country and

  13. Keys to Successful Quality Assurance and Quality Control Programs (101) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Keys to Successful Quality Assurance and Quality Control Programs (101) Keys to Successful Quality Assurance and Quality Control Programs (101) Better Buildings Residential Network Peer Exchange Call Series: Keys to Successful Quality Assurance and Quality Control Programs (101), call slides and discussion summary. Call Slides and Discussion Summary (1.79 MB) More Documents & Publications Quality Control, Standardization of Upgrades, and Workforce Expectations Home

  14. DOE Announces More Key Administration Posts | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Administration Posts DOE Announces More Key Administration Posts March 20, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Dr. Steven E. Koonin, Under Secretary for Science, Department of Energy; David Sandalow, Assistant Secretary for Policy and International Affairs, Department of Energy; Ambassador Johnnie Carson, Assistant Secretary for African Affairs, State Department; Kathy

  15. Key Board Products and Special Reports - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Board Products and Special Reports Hanford Advisory Board Convening Report SSAB Guidance Memorandum of Understanding Membership Nomination and Appointment Process Operating Ground Rules Calendars Advice and Responses Full Board Meeting Information Committee Meeting Information Outgoing Board Correspondence Key Board Products and Special Reports HAB Annual Report HAB and Committee Lists Points of Contact Related Links Key Board Products and Special Reports Email Email Page | Print Print Page

  16. Vehicle Technologies Office: Key Activities in Vehicles | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy About the Vehicle Technologies Office » Vehicle Technologies Office: Key Activities in Vehicles Vehicle Technologies Office: Key Activities in Vehicles We conduct work in four key areas to develop and deploy vehicle technologies that reduce the use of petroleum while maintaining or improving performance, power, and comfort. Research and development (R&D); testing and analysis; government and community stakeholder support; and education help people access and use efficient, clean

  17. Hydrodynamic experiment provides key data for Stockpile Stewardship

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hydrodynamic experiment provides Stockpile Stewardship key data Los Alamos hydrodynamic experiment provides key data for Stockpile Stewardship Hydrodynamic experiments such as Leda involve non-nuclear surrogate materials that mimic many of the properties of nuclear materials. December 22, 2014 Los Alamos hydrodynamic experiment provides key data for Stockpile Stewardship "Leda," experimental vessel in the "Zero Room" at the underground U1a facility, at the Nevada National

  18. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Iron is the Key to Preserving Dinosaur Soft Tissue Iron is the Key to Preserving Dinosaur Soft Tissue Print Thursday, 21 August 2014 10:43 Researchers studying organic material from dinosaur bones have been able to show that the organic material in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected preservation-iron nanoparticles associated with dinosaur blood vessels were

  19. TEC Working Group Topic Groups Security Key Documents | Department of

    Office of Environmental Management (EM)

    Energy Key Documents TEC Working Group Topic Groups Security Key Documents Key Documents Security TG Work Plan August 7, 2006 (24.31 KB) Security Lessons Learned Document August 2, 2006 (40.77 KB) Security Module (635.1 KB) STG Terms and Definitions from DOE 470.4 (18.54 KB) More Documents & Publications TEC Working Group Topic Groups Security Meeting Summaries TEC Meeting Summaries - April 2005 Presentations TEC Working Group Topic Groups Security Conference Call Summaries

  20. Key Dates | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Activities Key Activities Key Activities Bringing Innovative Manufacturing Technologies and Materials to Full "To Scale" Industrial Use Innovation is inherent in all of AMO's investment activities helping small, medium, and large manufacturers develop cutting-edge clean energy products and technology that reduce energy consumption in every stage or place it is used in industry. Built upon a foundation of strong public-private partnerships, our support of advanced manufacturing

  1. Key Dates | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Dates Visiting Faculty Program (VFP) VFP Home Eligibility Benefits Participant Obligations How to Apply Key Dates Frequently Asked Questions Contact WDTS Home Key Dates Print Text Size: A A A FeedbackShare Page At the submission deadline (shown in red) the application system will close, and no materials will be accepted after the submission deadline has passed. The Application System closes at 5:00 PM Eastern Time. VFP Term: Summer 2015 On-line Application Opens October 15, 2015 Applications

  2. 2015 Key Wind Program and National Laboratory Accomplishments | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 5 Key Wind Program and National Laboratory Accomplishments 2015 Key Wind Program and National Laboratory Accomplishments 2015 Key Wind Program and National Laboratory Accomplishments The U.S. Department of Energy (DOE) Wind Program is committed to helping the nation secure cost-competitive sources of renewable energy through the development and deployment of innovative wind power technologies. By investing in improvements to wind plant design, technology development, and operation

  3. DOE Announces More Key Administration Posts | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Key Administration Posts DOE Announces More Key Administration Posts March 27, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Ray Mabus, Secretary of the Navy, Department of Defense; Donald Remy, General Counsel of the Army, Department of Defense; J. Randolph Babbitt, Administrator, Federal Aviation Administration; Jose D. Riojas, Assistant Secretary for Operations, Security and

  4. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, D.N.

    1996-01-09

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

  5. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, Douglas N.

    1996-01-01

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

  6. SECTION L -ATTACHMENT B - LISTING OF KEY PERSONNEL

    National Nuclear Security Administration (NNSA)

    B, Page 1 SECTION L ATTACHMENT B LISTING OF KEY PERSONNEL TITLE NAME [Note: Add/remove extra rows if needed]

  7. Two Key NNSA Site Offices Registerd Under International Quality Standard |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) Two Key NNSA Site Offices Registerd Under International Quality Standard June 24, 2005 PDF icon NR06-05.pdf

  8. Geothermal regulations in Colorado---land ownership is the key...

    Open Energy Info (EERE)

    ownership is the key Author P. Morgan Published Journal Geothermal Resources Council- Transactions, 2012 DOI Not Provided Check for DOI availability: http:crossref.org...

  9. TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring...

    Office of Environmental Management (EM)

    Radiation Monitoring Subgroup TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring Subgroup Radiation Monitoring Subgroup PDF icon Draft Work Plan - February 4,...

  10. Binding Behavior of Dopamine Transporter Key to Understanding...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Understanding Chemical Reactions in the Brain Binding Behavior of Dopamine Transporter Key to Understanding Chemical Reactions in the Brain Print Wednesday, 09 December 2015 00:00 ...

  11. Key Parameters Affecting DPF Performance Degradation and Impact...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Parameters Affecting DPF Performance Degradation and Impact on Lifetime Fuel Economy Key Parameters Affecting DPF Performance Degradation and Impact on Lifetime Fuel Economy ...

  12. Key Energy-Saving Projects for Smaller Facilities | Department...

    Broader source: Energy.gov (indexed) [DOE]

    save energy and how the Industrial Assessment Centers can help. Briggs & Stratton provides examples of projects and implementation plans which worked for them. Key Energy-Saving ...

  13. President Obama Announces More Key Administration Posts | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Addthis THE WHITE HOUSE Office of the Press Secretary WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration ...

  14. California Energy Incentive Programs: An Annual Update on Key...

    Office of Environmental Management (EM)

    Energy Incentive Programs: An Annual Update on Key Energy Issues and Financial Opportunities for Federal Sites in California California Energy Incentive Programs: An Annual Update ...

  15. Key Practical Issues in Strengthening Safety Culture, INSAG-15

    Office of Energy Efficiency and Renewable Energy (EERE)

    Key Pratical Issues in Strengthening Safety Culture, INSAG-15. A report by the International Nuclear Safety Advisory Gorup, International Atomic Energy Agency, Vienna, 2002.

  16. Key Parameters Governing the Energy Density of Rechargeable Li...

    Office of Scientific and Technical Information (OSTI)

    of Rechargeable LiS Batteries Citation Details In-Document Search Title: Key Parameters Governing the Energy Density of Rechargeable LiS Batteries Authors: Gao, Jie ; ...

  17. LANL breaks ground on key sediment control project

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sediment control project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately 2 million features are up to eight feet high and...

  18. Pantex Plant Achieves Key Safety Milestone Ahead of Schedule...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Achieves Key Safety Milestone Ahead of Schedule | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing...

  19. Water dynamics clue to key residues in protein folding

    SciTech Connect (OSTI)

    Gao, Meng [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Zhu, Huaiqiu, E-mail: hqzhu@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Yao, Xin-Qiu [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China) [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Department of Biophysics, Kyoto University, Sakyo Kyoto 606-8502 (Japan); She, Zhen-Su, E-mail: she@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)

    2010-01-29

    A computational method independent of experimental protein structure information is proposed to recognize key residues in protein folding, from the study of hydration water dynamics. Based on all-atom molecular dynamics simulation, two key residues are recognized with distinct water dynamical behavior in a folding process of the Trp-cage protein. The identified key residues are shown to play an essential role in both 3D structure and hydrophobic-induced collapse. With observations on hydration water dynamics around key residues, a dynamical pathway of folding can be interpreted.

  20. NREL Fills Key Leadership Role for Energy Systems Security and...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fills Key Leadership Role for Energy Systems Security and Resilience April 6, 2015 Dr. ... a smart home, electricity storage, an electric vehicle charging station and solar panels. ...

  1. Rapid Compression Machine … A Key Experimental Device to Effectively...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    to Effectively Collaborate with Basic Energy Sciences Rapid Compression Machine A Key Experimental Device to Effectively Collaborate with Basic Energy Sciences 2011 DOE ...

  2. 2015 Key Water Power Program and National Laboratory Accomplishments...

    Broader source: Energy.gov (indexed) [DOE]

    2015 Key Water Power Program and National Laboratory Accomplishments Report The U.S. Department of Energy (DOE) Water Power Program is committed to developing and deploying a ...

  3. PEM Fuel Cell Technology, Key Research Needs and Approaches ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PEM FUEL CELL TECHNOLOGY Key Research Needs and Approaches Tom Jarvi UTC Power South ... Stationary CHP 40-80,000 hr components - seals, membranes Water management Robust systems ...

  4. Energy Critical Infrastructure and Key Resources Sector-Specific

    Broader source: Energy.gov (indexed) [DOE]

    Energy Critical Infrastructure and Key Resources Sector-Specific Plan as input to the National Infrastructure Protection Plan (Redacted) May 2007 Department of Energy Energy Sector ...

  5. Hydrodynamic experiment provides key data for Stockpile Stewardship

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    weapon performance in the absence of full-scale underground nuclear testing," said Webster. Los Alamos hydrodynamic experiment provides key data for Stockpile Stewardship In...

  6. Geothermal Regulations in Colorado - Land Ownership is the Key...

    Open Energy Info (EERE)

    Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference Paper: Geothermal Regulations in Colorado - Land Ownership is the Key Abstract Geothermal resources in...

  7. Liquid Water the Key to Arctic Cloud Radiative Closure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Water the Key to Arctic Cloud Radiative Closure For original submission and image(s), see ARM Research Highlights http:www.arm.govsciencehighlights Research Highlight...

  8. Guidance system for laser targets

    DOE Patents [OSTI]

    Porter, Gary D.; Bogdanoff, Anatoly

    1978-01-01

    A system for guiding charged laser targets to a predetermined focal spot of a laser along generally arbitrary, and especially horizontal, directions which comprises a series of electrostatic sensors which provide inputs to a computer for real time calculation of position, velocity, and direction of the target along an initial injection trajectory, and a set of electrostatic deflection means, energized according to a calculated output of said computer, to change the target trajectory to intercept the focal spot of the laser which is triggered so as to illuminate the target of the focal spot.

  9. Photosensitizer Conjugates For Pathogen Targeting

    DOE Patents [OSTI]

    Hasan, Tayyaba; Hamblin, Michael R.; Soukos, Nikos

    2002-10-08

    Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.

  10. Flight Path Target 4 East Port

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 East Port Target 4 East Port Links Flight Path Overview Target 4 East Port About Target 4 East Port Collaborators Publications Links

  11. Flight Path Target 4 East Port

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 East Port Target 4 East Port Links Flight Path Overview Target 4 East Port About Target 4 East Port Collaborators Publications Links

  12. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A.; Wang, Amy W.

    2002-01-01

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  13. TEC Working Group Topic Groups Rail Key Documents Intermodal Subgroup |

    Office of Environmental Management (EM)

    Department of Energy Intermodal Subgroup TEC Working Group Topic Groups Rail Key Documents Intermodal Subgroup Intermodal Subgroup Draft Work Plan (206.83 KB) More Documents & Publications TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring Subgroup TEC Working Group Topic Groups Rail Conference Call Summaries Intermodal Subgroup TEC Working Group Topic Groups Rail Conference Call Summaries Rail Topic Group

  14. Apparatus, system, and method for synchronizing a timer key

    DOE Patents [OSTI]

    Condit, Reston A; Daniels, Michael A; Clemens, Gregory P; Tomberlin, Eric S; Johnson, Joel A

    2014-04-22

    A timer key relating to monitoring a countdown time of a countdown routine of an electronic device is disclosed. The timer key comprises a processor configured to respond to a countdown time associated with operation of the electronic device, a display operably coupled with the processor, and a housing configured to house at least the processor. The housing has an associated structure configured to engage with the electronic device to share the countdown time between the electronic device and the timer key. The processor is configured to begin a countdown routine based at least in part on the countdown time, wherein the countdown routine is at least substantially synchronized with a countdown routine of the electronic device when the timer key is removed from the electronic device. A system and method for synchronizing countdown routines of a timer key and an electronic device are also disclosed.

  15. Practical issues in quantum-key-distribution postprocessing

    SciTech Connect (OSTI)

    Fung, C.-H. Fred; Chau, H. F. [Department of Physics and Center of Theoretical and Computational Physics, University of Hong Kong, Pokfulam Road (Hong Kong); Ma Xiongfeng [Institute for Quantum Computing and Department of Physics and Astronomy, University of Waterloo, 200 University Ave W., Waterloo, Ontario, Canada N2L 3G1 (Canada)

    2010-01-15

    Quantum key distribution (QKD) is a secure key generation method between two distant parties by wisely exploiting properties of quantum mechanics. In QKD, experimental measurement outcomes on quantum states are transformed by the two parties to a secret key. This transformation is composed of many logical steps (as guided by security proofs), which together will ultimately determine the length of the final secret key and its security. We detail the procedure for performing such classical postprocessing taking into account practical concerns (including the finite-size effect and authentication and encryption for classical communications). This procedure is directly applicable to realistic QKD experiments and thus serves as a recipe that specifies what postprocessing operations are needed and what the security level is for certain lengths of the keys. Our result is applicable to the BB84 protocol with a single or entangled photon source.

  16. Realizing Technologies for Magnetized Target Fusion

    SciTech Connect (OSTI)

    Wurden, Glen A.

    2012-08-24

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  17. Magnetized Target Fusion Collaboration. Final report

    SciTech Connect (OSTI)

    John Slough

    2012-04-18

    these IPAs have demonstrated the ability to rapidly form, accelerate and merge two hypervelocity FRCs into a compression chamber. The resultant FRC that was formed was hot (T{sub ion} ~ 400 eV), stationary, and stable with a configuration lifetime several times that necessary for the MTF liner experiments. The accelerator length was less than 1 meter, and the time from the initiation of formation to the establishment of the final equilibrium was less than 10 microseconds. With some modification, each accelerator can be made capable of producing FRCs suitable for the production of the target plasma for the MTF liner experiment. Based on the initial FRC merging/compression results, the design and methodology for an experimental realization of the target plasma for the MTF liner experiment can now be defined. The construction and testing of the key components for the formation of the target plasma at the Air Force Research Laboratory (AFRL) will be performed on the IPA experiment, now at MSNW. A high density FRC plasmoid will be formed and accelerated out of each IPA into a merging/compression chamber similar to the imploding liner at AFRL. The properties of the resultant FRC plasma (size, temperature, density, flux, lifetime) will be obtained. The process will be optimized, and a final design for implementation at AFRL will be carried out. When implemented at AFRL it is anticipated that the colliding/merging FRCs will then be compressed by the liner. In this manner it is hoped that ultimately a plasma with ion temperatures reaching the 10 keV range and fusion gain near unity can be obtained.

  18. A probabilistic approach to microRNA-target binding

    SciTech Connect (OSTI)

    Ogul, Hasan; Umu, Sinan U.; Bioinformatics Program, Informatics Institute, Middle East Technical University, Cankaya TR-06800, Ankara ; Tuncel, Y. Yener; Akkaya, Mahinur S.

    2011-09-16

    Highlights: {yields} A new probabilistic model is introduced for microRNA-target binding. {yields} The new model significantly outperforms RNAHybrid and miRTif. {yields} The experiments can unveil the effects of the type and directions of distinct base pairings. -- Abstract: Elucidation of microRNA activity is a crucial step in understanding gene regulation. One key problem in this effort is how to model the pairwise interactions of microRNAs with their targets. As this interaction is strongly mediated by their sequences, it is desired to set-up a probabilistic model to explain the binding preferences between a microRNA sequence and the sequence of a putative target. To this end, we introduce a new model of microRNA-target binding, which transforms an aligned duplex to a new sequence and defines the likelihood of this sequence using a Variable Length Markov Chain. It offers a complementary representation of microRNA-mRNA pairs for microRNA target prediction tools or other probabilistic frameworks of integrative gene regulation analysis. The performance of present model is evaluated by its ability to predict microRNA-target mRNA interaction given a mature microRNA sequence and a putative mRNA binding site. In regard to classification accuracy, it outperforms two recent methods based on thermodynamic stability and sequence complementarity. The experiments can also unveil the effects of base pairing types and non-seed region in duplex formation.

  19. Proposed generation and compression of a target plasma for MTF

    SciTech Connect (OSTI)

    Kirkpatrick, R.C.; Thurston, R.S.; Chrien, R.E.

    1995-09-01

    Magnetized target fusion (MTF), in which a magnetothermally insulated plasma is hydrodynamically compressed to fusion conditions, represents an approach to controlled fusion which avoids difficulties of both traditional inertial confinement and magnetic confinement approaches. The authors are proposing to demonstrate the feasibility of magnetized target fusion by: (1) creating a suitable magnetized target plasma, (2) performing preliminary liner compression experiments using existing pulsed power facilities and demonstrated liner performance. Once the target plasma and the means for its generation have been optimized, the authors plan to conduct preliminary liner compression experiments aimed at demonstrating the near-adiabatic compression of the target plasma desired for MTF. Relevant liner compression experiments have been performed at Los Alamos in the Scyllac Fast Liner Program and, more recently, in the Pegasus facility and the Procyon explosive pulsed power program. In a series of liner experiments they plan to map out the dependence of temperature and neutron production as functions of the initial plasma conditions and the liner compression achieved. With the above research program, they intend to demonstrate most of the key principles involved in magnetized target fusion, and develop the experimental and theoretical tools needed to design and execute fully integrated MTF ignition experiments.

  20. Authenticated group Diffie-Hellman key exchange: theory and practice

    SciTech Connect (OSTI)

    Chevassut, Olivier

    2002-10-03

    Authenticated two-party Diffie-Hellman key exchange allows two principals A and B, communicating over a public network, and each holding a pair of matching public/private keys to agree on a session key. Protocols designed to deal with this problem ensure A (B resp.)that no other principals aside from B (A resp.) can learn any information about this value. These protocols additionally often ensure A and B that their respective partner has actually computed the shared secret value. A natural extension to the above cryptographic protocol problem is to consider a pool of principals agreeing on a session key. Over the years several papers have extended the two-party Diffie-Hellman key exchange to the multi-party setting but no formal treatments were carried out till recently. In light of recent developments in the formalization of the authenticated two-party Diffie-Hellman key exchange we have in this thesis laid out the authenticated group Diffie-Hellman key exchange on firmer foundations.

  1. Development of a public key infrastructure across multiple enterprises

    SciTech Connect (OSTI)

    Sharick, T.M.; Long, J.P.; Desind, B.J.

    1997-05-01

    Main-stream applications are beginning to incorporate public key cryptography. It can be difficult to deploy this technology without a robust infrastructure to support it. It can also be difficult to deploy a public key infrastructure among multiple enterprises when different applications and standards must be supported. This discussion chronicles the efforts by a team within the US Department of Energy`s Nuclear Weapons Complex to build a public key infrastructure and deploy applications that use it. The emphasis of this talk will be on the lessons learned during this effort and an assessment of the overall impact of this technology.

  2. Random Selection for Drug Screening (Technical Report) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Subject: 99 GENERAL AND MISCELLANEOUSMATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; PROBABILITY; SAMPLING; DRUG ABUSE; DRUGS; CRIME DETECTION drug screenings, random selection ...

  3. Inertial-confinement-fusion targets

    SciTech Connect (OSTI)

    Hendricks, C.D.

    1982-08-10

    Much of the research in laser fusion has been done using simple ball on-stalk targets filled with a deuterium-tritium mixture. The targets operated in the exploding pusher mode in which the laser energy was delivered in a very short time (approx. 100 ps or less) and was absorbed by the glass wall of the target. The high energy density in the glass literally exploded the shell with the inward moving glass compressing the DT fuel to high temperatures and moderate densities. Temperatures achieved were high enough to produce DT reactions and accompanying thermonuclear neutrons and alpha particles. The primary criteria imposed on the target builders were: (1) wall thickness, (2) sphere diameter, and (3) fuel in the sphere.

  4. Structure Based Drug Design for HIM Protease: From Molecular Modeling to Cheminformatics

    SciTech Connect (OSTI)

    Volarath, Patra; Weber, Irene T.; Harrison, Robert W.

    2008-06-06

    Significant progress over the past decade in virtual representations of molecules and their physicochemical properties has produced new drugs from virtual screening of the structures of single protein molecules by conventional modeling methods. The development of clinical antiviral drugs from structural data for HIV protease has been a major success in structure based drug design. Techniques for virtual screening involve the ranking of the affinity of potential ligands for the target site on a protein. Two main alternatives have been developed: modeling of the target protein with a series of related ligand molecules, and docking molecules from a database to the target protein site. The computational speed and prediction accuracy will depend on the representation of the molecular structure and chemistry, the search or simulation algorithm, and the scoring function to rank the ligands. Moreover, the general challenges in modern computational drug design arise from the profusion of data, including whole genomes of DNA, protein structures, chemical libraries, affinity and pharmacological data. Therefore, software tools are being developed to manage and integrate diverse data, and extract and visualize meaningful relationships. Current areas of research include the development of searchable chemical databases, which requires new algorithms to represent molecules and search for structurally or chemically similar molecules, and the incorporation of machine learning techniques for data mining to improve the accuracy of predictions. Examples will be presented for the virtual screening of drugs that target HIV protease.

  5. Ion beam inertial confinement target

    DOE Patents [OSTI]

    Bangerter, Roger O.; Meeker, Donald J.

    1985-01-01

    A target for implosion by ion beams composed of a spherical shell of frozen DT surrounded by a low-density, low-Z pusher shell seeded with high-Z material, and a high-density tamper shell. The target has various applications in the inertial confinement technology. For certain applications, if desired, a low-density absorber shell may be positioned intermediate the pusher and tamper shells.

  6. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected...

  7. Reply to 'Comment on 'Quantum dense key distribution''

    SciTech Connect (OSTI)

    Degiovanni, I.P.; Berchera, I. Ruo; Castelletto, S.; Rastello, M.L.; Bovino, F.A.; Colla, A.M.; Castagnoli, G.

    2005-01-01

    In this Reply we propose a modified security proof of the quantum dense key distribution protocol, detecting also the eavesdropping attack proposed by Wojcik in his Comment [Wojcik, Phys. Rev. A 71, 016301 (2005)].

  8. Key Mobility Challenges in Indian Cities | Open Energy Information

    Open Energy Info (EERE)

    from the LEDS Global Partnership. When to Use This Tool While building a low emission strategy for your country's transportation system, this tool is most useful during these key...

  9. Copper is Key in Burning Fat, New Study Finds

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Copper is Key in Burning Fat, New Study Finds A new study led by a Berkeley Lab scientist ... Researchers want to explore if a copper deficiency is linked to obesity and obesity ...

  10. Worldwide Trends in Energy Use and Efficiency: Key Insights from...

    Open Energy Info (EERE)

    Trends in Energy Use and Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Jump to:...

  11. Key energy efficiency measures signed into law by President Obama...

    Open Energy Info (EERE)

    Key energy efficiency measures signed into law by President Obama Home > Groups > OpenEI Community Central Graham7781's picture Submitted by Graham7781(2017) Super contributor 2...

  12. Quantum key distribution using card, base station and trusted authority

    DOE Patents [OSTI]

    Nordholt, Jane Elizabeth; Hughes, Richard John; Newell, Raymond Thorson; Peterson, Charles Glen; Rosenberg, Danna; McCabe, Kevin Peter; Tyagi, Kush T; Dallman, Nicholas

    2015-04-07

    Techniques and tools for quantum key distribution ("QKD") between a quantum communication ("QC") card, base station and trusted authority are described herein. In example implementations, a QC card contains a miniaturized QC transmitter and couples with a base station. The base station provides a network connection with the trusted authority and can also provide electric power to the QC card. When coupled to the base station, after authentication by the trusted authority, the QC card acquires keys through QKD with a trusted authority. The keys can be used to set up secure communication, for authentication, for access control, or for other purposes. The QC card can be implemented as part of a smart phone or other mobile computing device, or the QC card can be used as a fillgun for distribution of the keys.

  13. Catalysis Center for Energy Innovation KEY ACCOMPLISHMENTS AND CORE CAPABILITIES

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    KEY ACCOMPLISHMENTS AND CORE CAPABILITIES CCEI 1 TABLE OF CONTENTS Introduction and Overview of Discoveries and Breakthroughs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Core Capabilities: Multiscale Modeling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Solution-phase Chemistry with Accelerated Molecular Dynamics Methods . . . . . . . . . . . . . . . . . .

  14. NREL: Wind Research - NREL and Partners Review Key Issues, Lessons...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NREL and Partners Review Key Issues, Lessons Learned from U.S. Wind Integration Studies and Operating Practices April 17, 2015 As a complement to DOE's recently released Wind...

  15. Potential for Hydrogen Production from Key Renewable Resources...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Potential for Hydrogen Production from Key Renewable Resources in the United States A. Milbrandt and M. Mann Technical Report NRELTP-640-41134 February 2007 NREL is operated by...

  16. EnergySmart Schools National Financing Roundtable - Key Outcomes

    SciTech Connect (OSTI)

    2009-04-01

    This document presents key outcomes from the EnergySmart Schools National Financing Roundtable as a follow-up to the release of its Guide to FInancing EnergySmart Schools

  17. Key Publications - Natural Gas Regulation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Services » Natural Gas Regulation » Key Publications - Natural Gas Regulation Key Publications - Natural Gas Regulation Natural Gas Imports and Exports - Quarterly Reports May 11, 2016 Natural Gas Imports and Exports Fourth Quarter Report 2015 February 3, 2016 Natural Gas Imports and Exports Third Quarter Report 2015 October 30, 2015 Natural Gas Imports and Exports Second Quarter Report 2015 August 13, 2015 Natural Gas Imports and Exports First Quarter Report 2015 More Quarterly Reports LNG

  18. Key-and-keyway coupling for transmitting torque

    DOE Patents [OSTI]

    Blue, S.C.; Curtis, M.T.; Orthwein, W.C.; Stitt, D.H.

    1975-11-18

    The design of an improved key-and-keyway coupling for the transmission of torque is given. The coupling provides significant reductions in stress concentrations in the vicinity of the key and keyway. The keyway is designed with a flat-bottomed u-shaped portion whose inboard end terminates in a ramp which is dished transversely, so that the surface of the ramp as viewed in transverse section defines an outwardly concave arc.

  19. Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion Print Friday, 19 February 2016 13:11 The burning of fossil fuels and the consequent rising levels of atmospheric CO-2 has led to a number of negative environmental consequences, including global warming and ocean acidification. Converting CO2 to fuels or chemical feedstock, ideally through the use of renewable energy, can simultaneously reduce atmospheric

  20. Binding Behavior of Dopamine Transporter Key to Understanding Chemical

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reactions in the Brain Binding Behavior of Dopamine Transporter Key to Understanding Chemical Reactions in the Brain Binding Behavior of Dopamine Transporter Key to Understanding Chemical Reactions in the Brain Print Wednesday, 09 December 2015 00:00 Most people have heard of adrenaline, the chemical that causes the "fight or flight" reaction in humans. Most people have also heard of the chemical substances cocaine and methamphetamine, which also elicit a particular (perhaps

  1. Single, Key Gene Discovery Could Streamline Production of Biofuels |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels August 11, 2011 - 3:51pm Addthis WASHINGTON, DC -- A team of researchers at the Department of Energy's BioEnergy Science Center (BESC) have pinpointed the exact, single gene that controls ethanol production capacity in a microorganism. This discovery could be the missing link in developing biomass crops that produce higher concentrations

  2. What Are the Computational Keys to Future Scientific Discoveries?

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    What are the Computational Keys to Future Scientific Discoveries? What Are the Computational Keys to Future Scientific Discoveries? NERSC Develops a Data Intensive Pilot Program to Help Scientists Find Out August 23, 2012 Linda Vu,lvu@lbl.gov, +1 510 495 2402 ALS.jpg Advanced Light Source at the Lawrence Berkeley National Laboratory. (Photo by: Roy Kaltschmidt, Berkeley Lab) A new camera at the hard x-ray tomography beamline of Lawrence Berkeley National Laboratory's (Berkeley Lab's) Advanced

  3. Energy Storage: The Key to a Reliable, Clean Electricity Supply |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Storage: The Key to a Reliable, Clean Electricity Supply Energy Storage: The Key to a Reliable, Clean Electricity Supply February 22, 2012 - 4:52pm Addthis Improved energy storage technology offers a number of economic and environmental benefits. Improved energy storage technology offers a number of economic and environmental benefits. Matthew Loveless Matthew Loveless Data Integration Specialist, Office of Public Affairs What does this project do? ARPA-E's GRIDS program

  4. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Iron is the Key to Preserving Dinosaur Soft Tissue Print Researchers studying organic material from dinosaur bones have been able to show that the organic material in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected preservation-iron nanoparticles associated with dinosaur blood vessels were identified at the ALS. Researchers hypothesized that the iron had come from dinosaurs'

  5. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Iron is the Key to Preserving Dinosaur Soft Tissue Print Researchers studying organic material from dinosaur bones have been able to show that the organic material in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected preservation-iron nanoparticles associated with dinosaur blood vessels were identified at the ALS. Researchers hypothesized that the iron had come from dinosaurs'

  6. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Iron is the Key to Preserving Dinosaur Soft Tissue Print Researchers studying organic material from dinosaur bones have been able to show that the organic material in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected preservation-iron nanoparticles associated with dinosaur blood vessels were identified at the ALS. Researchers hypothesized that the iron had come from dinosaurs'

  7. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Iron is the Key to Preserving Dinosaur Soft Tissue Print Researchers studying organic material from dinosaur bones have been able to show that the organic material in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected preservation-iron nanoparticles associated with dinosaur blood vessels were identified at the ALS. Researchers hypothesized that the iron had come from dinosaurs'

  8. 2015 Key Water Power Program and National Laboratory Accomplishments Report

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Water Power Program and National Laboratory Accomplishments 2015 Key Water Power Program and National Laboratory Accomplishments | 1 | 2015 Key Water Power Program and National Laboratory Accomplishments The U.S. Department of Energy (DOE) Water Power Program is committed to developing and deploying a portfolio of innovative technologies and market solutions for clean, domestic power generation from water resources across the United States. By accelerating the development of markets for

  9. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Iron is the Key to Preserving Dinosaur Soft Tissue Print Researchers studying organic material from dinosaur bones have been able to show that the organic material in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected preservation-iron nanoparticles associated with dinosaur blood vessels were identified at the ALS. Researchers hypothesized that the iron had come from dinosaurs'

  10. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Iron is the Key to Preserving Dinosaur Soft Tissue Print Researchers studying organic material from dinosaur bones have been able to show that the organic material in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected preservation-iron nanoparticles associated with dinosaur blood vessels were identified at the ALS. Researchers hypothesized that the iron had come from dinosaurs'

  11. Iron is the Key to Preserving Dinosaur Soft Tissue

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Iron is the Key to Preserving Dinosaur Soft Tissue Print Researchers studying organic material from dinosaur bones have been able to show that the organic material in the samples contained original soft tissue material from Mesozoic dinosaurs. The x-ray techniques at the ALS were key to showing a possible mechanism for this unexpected preservation-iron nanoparticles associated with dinosaur blood vessels were identified at the ALS. Researchers hypothesized that the iron had come from dinosaurs'

  12. TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring

    Office of Environmental Management (EM)

    Subgroup | Department of Energy Radiation Monitoring Subgroup TEC Working Group Topic Groups Rail Key Documents Radiation Monitoring Subgroup Radiation Monitoring Subgroup Draft Work Plan - February 4, 2008 (114.02 KB) More Documents & Publications TEC Working Group Topic Groups Rail Meeting Summaries TEC Working Group Topic Groups Rail Conference Call Summaries Radiation Monitoring Subgroup TEC Working Group Topic Groups Rail Key Documents Intermodal Subgroup

  13. Missing Oxygen Atoms Are Key to Robust Spintronic Material

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Missing Oxygen Atoms Are Key to Robust Spintronic Material Missing Oxygen Atoms Are Key to Robust Spintronic Material Print Friday, 01 April 2016 11:44 The endless pursuit of faster, more energy-efficient computers has led to the emergence of the field of spintronics, where the manipulation and detection of electron spins are utilized in electronic circuits. A particular class of materials called dilute magnetic oxides are promising candidates for spintronics applications because they exhibit

  14. NERSC Played Key Role in Nobel Laureate's Discovery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC Played Key Role in Nobel Laureate's Discovery NERSC Played Key Role in Nobel Laureate's Discovery NERSC, Berkeley Lab Now Centers for Computational Cosmology Community October 4, 2011 Contact: Jon Bashor, jbashor@lbl.gov, +1 510 486 5849 In the 1990s, Saul Perlmutter discovered that the universe is expanding at an accelerating rate. He confirmed his observational conclusions by running thousands of simulations at the National Energy Research Scientific Computing Center (NERSC) at Lawrence

  15. Midstream Infrastructure Improvements Key to Realizing Full Potential of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Domestic Natural Gas | Department of Energy Midstream Infrastructure Improvements Key to Realizing Full Potential of Domestic Natural Gas Midstream Infrastructure Improvements Key to Realizing Full Potential of Domestic Natural Gas October 30, 2014 - 9:20am Addthis Natural gas provides numerous benefits to millions of Americans daily, whether it's being used to heat or air condition homes and businesses, cook meals, or power vehicles. But most people who take advantage of this versatile and

  16. Update On The Development, Testing, And Manufacture Of High Density LEU-Foil Targets For The Production Of Mo-99

    SciTech Connect (OSTI)

    Creasy, John T

    2015-05-12

    This project has the objective to reduce and/or eliminate the use of HEU in commerce. Steps in the process include developing a target testing methodology that is bounding for all Mo-99 target irradiators, establishing a maximum target LEU-foil mass, developing a LEU-foil target qualification document, developing a bounding target failure analysis methodology (failure in reactor containment), optimizing safety vs. economics (goal is to manufacture a safe, but relatively inexpensive target to offset the inherent economic disadvantage of using LEU in place of HEU), and developing target material specifications and manufacturing QC test criteria. The slide presentation is organized under the following topics: Objective, Process Overview, Background, Team Structure, Key Achievements, Experiment and Activity Descriptions, and Conclusions. The High Density Target project has demonstrated: approx. 50 targets irradiated through domestic and international partners; proof of concept for two front end processing methods; fabrication of uranium foils for target manufacture; quality control procedures and steps for manufacture; multiple target assembly techniques; multiple target disassembly devices; welding of targets; thermal, hydraulic, and mechanical modeling; robust target assembly parametric studies; and target qualification analysis for insertion into very high flux environment. The High Density Target project has tested and proven several technologies that will benefit current and future Mo-99 producers.

  17. Targets and methods for target preparation for radionuclide production

    DOE Patents [OSTI]

    Zhuikov, Boris L; Konyakhin, Nicolai A; Kokhanyuk, Vladimir M; Srivastava, Suresh C

    2012-10-16

    The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti--Sb, Al--Sb, Cu--Sb, or Ni--Sb in order to produce radionuclides (e.g., tin-117 m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.

  18. Materials considerations in accelerator targets

    SciTech Connect (OSTI)

    Peacock, H.B. Jr.; Iyer, N.C.; Louthan, M.R. Jr.

    1994-08-01

    Future nuclear materials production and/or the burn-up of long lived radioisotopes may be accomplished through the capture of spallation produced neutrons in accelerators. Aluminum clad-lead and/or lead alloys has been proposed as a spallation target. Aluminum was the cladding choice because of the low neutron absorption cross section, fast radioactivity decay, high thermal conductivity, and excellent fabricability. Metallic lead and lead oxide powders were considered for the target core with the fabrication options being casting or powder metallurgy (PM). Scoping tests to evaluate gravity casting, squeeze casting, and casting and swaging processes showed that, based on fabricability and heat transfer considerations, squeeze casting was the preferred option for manufacture of targets with initial core cladding contact. Thousands of aluminum clad aluminum-lithium alloy core targets and control rods for tritium production have been fabricated by coextrusion processes and successfully irradiated in the SRS reactors. Tritium retention in, and release from the coextruded product was modeled from experimental and operational data. Newly produced tritium atoms were trapped by lithium atoms to form a lithium tritide. The effective tritium pressure required for trap or tritide stability was the equilibrium decomposition pressure of tritium over a lithium tritide-aluminum mixture. The temperature dependence of tritium release was determined by the permeability of the cladding to tritium and the local equilibrium at the trap sites. The model can be used to calculate tritium release from aluminum clad, aluminum-lithium alloy targets during postulated accelerator operational and accident conditions. This paper describes the manufacturing technologies evaluated and presents the model for tritium retention in aluminum clad, aluminum-lithium alloy tritium production targets.

  19. Apparatus for producing laser targets

    DOE Patents [OSTI]

    Jarboe, T.R.; Baker, W.R.

    1975-09-23

    This patent relates to an apparatus and method for producing deuterium targets or pellets of 25u to 75u diameter. The pellets are sliced from a continuously spun solid deuterium thread at a rate of up to 10 pellets/second. The pellets after being sliced from the continuous thread of deuterium are collimated and directed to a point of use, such as a laser activated combustion or explosion chamber wherein the pellets are imploded by laser energy or laser produced target plasmas for neutral beam injection. (auth)

  20. Method for producing laser targets

    DOE Patents [OSTI]

    Jarboe, Thomas R.; Baker, William R.

    1977-01-01

    An apparatus and method for producing deuterium targets or pellets of 25.mu. to 75.mu. diameter. The pellets are sliced from a continuously spun solid deuterium thread at a rate of up to 10 pellets/second. The pellets after being sliced from the continuous thread of deuterium are collimated and directed to a point of use, such as a laser activated combustion or explosion chamber wherein the pellets are imploded by laser energy or laser produced target plasmas for neutral beam injection.

  1. Secret Key Generation via a Modified Quantum Secret Sharing Protocol

    SciTech Connect (OSTI)

    Smith IV, Amos M; Evans, Philip G; Lawrie, Benjamin J; Legre, Matthieu; Lougovski, Pavel; Ray, William R; Williams, Brian P; Qi, Bing; Grice, Warren P

    2015-01-01

    We present and experimentally show a novel protocol for distributing secret information between two and only two parties in a N-party single-qubit Quantum Secret Sharing (QSS) system. We demonstrate this new algorithm with N = 3 active parties over 6km of telecom. ber. Our experimental device is based on the Clavis2 Quantum Key Distribution (QKD) system built by ID Quantique but is generalizable to any implementation. We show that any two out of the N parties can build secret keys based on partial information from each other and with collaboration from the remaining N > 2 parties. This algorithm allows for the creation of two-party secret keys were standard QSS does not and signicantly reduces the number of resources needed to implement QKD on a highly connected network such as the electrical grid.

  2. GE Key Partner in Innovation Institutes | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Is Key Partner in Manufacturing Innovation Institutes Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Tumblr (Opens in new window) GE Is Key Partner in Manufacturing Innovation Institutes GE Global Research 2014.02.25 President Obama today announced two new manufacturing innovation institutes. One is focused on digital manufacturing and design

  3. Energy Secretary Bodman Commends Key Milestone In MOX Program | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Commends Key Milestone In MOX Program Energy Secretary Bodman Commends Key Milestone In MOX Program April 1, 2005 - 11:28am Addthis WASHINGTON, DC - In response to the Nuclear Regulatory Commission's (NRC) authorization of the construction of a U.S. Mixed-Oxide (MOX) Fuel Fabrication Facility at the Department of Energy's Savannah River Site in South Carolina, Secretary of Energy Samuel W. Bodman today released the following statement: "Issuing the permit for construction of a

  4. SimTable key tool for preparing, responding to wildfire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SimTable key tool for preparing, responding to wildfire SimTable key tool for preparing, responding to wildfire Camera tracks movement and objects and project them onto a sand table. May 30, 2012 SimTable: Stephen Guerin (L) and Chip Garner (R) with SimTable, a Santa Fe company helping firefighters model and predict where a fire is most likely to spread, received support for their business through Lab economic development programs: VAF, NMSBA, Springboard. SimTable: Stephen Guerin (L) and Chip

  5. Implications of structural genomics target selection strategies...

    Office of Scientific and Technical Information (OSTI)

    target selection strategies: Pfam5000, whole genome, and random approaches Citation Details In-Document Search Title: Implications of structural genomics target selection ...

  6. Enterprise Assessments Targeted Review, Sandia National Laboratories...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Review, Sandia National Laboratories - November 2014 Enterprise Assessments Targeted Review, Sandia National Laboratories - November 2014 November 2014 Targeted Review of Work ...

  7. Independent Oversight Targeted Review, Sandia National Laboratories...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Targeted Review, Sandia National Laboratories - November 2013 December 2013 Targeted Review of Activity-Level Implementation of Radiological Controls at Sandia National ...

  8. Independent Oversight Targeted Review, Sandia National Laboratories...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    April 2014 Independent Oversight Targeted Review, Sandia National Laboratories - April 2014 April 2014 Targeted Review of the Sandia National Laboratories Federal Assurance ...

  9. Enterprise Assessments Lessons Learned from Targeted Reviews...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from Targeted Reviews of Fire Protection Programs at Department of Energy Facilities - August 2015 Enterprise Assessments Lessons Learned from Targeted Reviews of Fire ...

  10. A Prospective Target for Advanced Biofuel Production

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Prospective Target for Advanced Biofuel Production A Prospective Target for Advanced Biofuel Production Print Thursday, 02 February 2012 13:34 The sesquiterpene bisabolene was...

  11. Foam shell cryogenic ICF target

    DOE Patents [OSTI]

    Darling, Dale H.

    1987-01-01

    A uniform cryogenic layer of DT fuel is maintained in a fusion target having a low density, small pore size, low Z rigid foam shell saturated with liquid DT fuel. Capillary action prevents gravitational slumping of the fuel layer. The saturated shell may be cooled to produce a solid fuel layer.

  12. High power neutron production targets

    SciTech Connect (OSTI)

    Wender, S.

    1996-06-01

    The author describes issues of concern in the design of targets and associated systems for high power neutron production facilities. The facilities include uses for neutron scattering, accelerator driven transmutation, accelerator production of tritium, short pulse spallation sources, and long pulse spallation sources. Each of these applications requires a source with different design needs and consequently different implementation in practise.

  13. Computational modeling predicts simultaneous targeting of fibroblasts and epithelial cells is necessary for treatment of pulmonary fibrosis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Warsinske, Hayley C.; Wheaton, Amanda K.; Kim, Kevin K.; Linderman, Jennifer J.; Moore, Bethany B.; Kirschner, Denise E.

    2016-06-23

    Pulmonary fibrosis is pathologic remodeling of lung tissue that can result in difficulty breathing, reduced quality of life, and a poor prognosis for patients. Fibrosis occurs as a result of insult to lung tissue, though mechanisms of this response are not well-characterized. The disease is driven in part by dysregulation of fibroblast proliferation and differentiation into myofibroblast cells, as well as pro-fibrotic mediator-driven epithelial cell apoptosis. The most well-characterized pro-fibrotic mediator associated with pulmonary fibrosis is TGF-β1. Excessive synthesis of, and sensitivity to, pro-fibrotic mediators as well as insufficient production of and sensitivity to anti-fibrotic mediators has been credited withmore » enabling fibroblast accumulation. Available treatments neither halt nor reverse lung damage. In this study we have two aims: to identify molecular and cellular scale mechanisms driving fibroblast proliferation and differentiation as well as epithelial cell survival in the context of fibrosis, and to predict therapeutic targets and strategies. We combine in vitro studies with a multi-scale hybrid agent-based computational model that describes fibroblasts and epithelial cells in co-culture. Within this model TGF-β1 represents a pro-fibrotic mediator and we include detailed dynamics of TGFβ1 receptor ligand signaling in fibroblasts. PGE2 represents an anti-fibrotic mediator. Using uncertainty and sensitivity analysis we identify TGF-β1 synthesis, TGF-β1 activation, and PGE2 synthesis among the key mechanisms contributing to fibrotic outcomes. We further demonstrate that intervention strategies combining potential therapeutics targeting both fibroblast regulation and epithelial cell survival can promote healthy tissue repair better than individual strategies. Combinations of existing drugs and compounds may provide significant improvements to the current standard of care for pulmonary fibrosis. In conclusion, a two-hit therapeutic

  14. Self-referenced continuous-variable quantum key distribution protocol

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Soh, Daniel B. S.; Brif, Constantin; Coles, Patrick J.; Lutkenhaus, Norbert; Camacho, Ryan M.; Urayama, Junji; Sarovar, Mohan

    2015-10-21

    Here, we introduce a new continuous-variable quantum key distribution (CV-QKD) protocol, self-referenced CV-QKD, that eliminates the need for transmission of a high-power local oscillator between the communicating parties. In this protocol, each signal pulse is accompanied by a reference pulse (or a pair of twin reference pulses), used to align Alice’s and Bob’s measurement bases. The method of phase estimation and compensation based on the reference pulse measurement can be viewed as a quantum analog of intradyne detection used in classical coherent communication, which extracts the phase information from the modulated signal. We present a proof-of-principle, fiber-based experimental demonstration ofmore » the protocol and quantify the expected secret key rates by expressing them in terms of experimental parameters. Our analysis of the secret key rate fully takes into account the inherent uncertainty associated with the quantum nature of the reference pulse(s) and quantifies the limit at which the theoretical key rate approaches that of the respective conventional protocol that requires local oscillator transmission. The self-referenced protocol greatly simplifies the hardware required for CV-QKD, especially for potential integrated photonics implementations of transmitters and receivers, with minimum sacrifice of performance. As such, it provides a pathway towards scalable integrated CV-QKD transceivers, a vital step towards large-scale QKD networks.« less

  15. Self-referenced continuous-variable quantum key distribution protocol

    SciTech Connect (OSTI)

    Soh, Daniel B. S.; Brif, Constantin; Coles, Patrick J.; Lutkenhaus, Norbert; Camacho, Ryan M.; Urayama, Junji; Sarovar, Mohan

    2015-10-21

    Here, we introduce a new continuous-variable quantum key distribution (CV-QKD) protocol, self-referenced CV-QKD, that eliminates the need for transmission of a high-power local oscillator between the communicating parties. In this protocol, each signal pulse is accompanied by a reference pulse (or a pair of twin reference pulses), used to align Alice’s and Bob’s measurement bases. The method of phase estimation and compensation based on the reference pulse measurement can be viewed as a quantum analog of intradyne detection used in classical coherent communication, which extracts the phase information from the modulated signal. We present a proof-of-principle, fiber-based experimental demonstration of the protocol and quantify the expected secret key rates by expressing them in terms of experimental parameters. Our analysis of the secret key rate fully takes into account the inherent uncertainty associated with the quantum nature of the reference pulse(s) and quantifies the limit at which the theoretical key rate approaches that of the respective conventional protocol that requires local oscillator transmission. The self-referenced protocol greatly simplifies the hardware required for CV-QKD, especially for potential integrated photonics implementations of transmitters and receivers, with minimum sacrifice of performance. As such, it provides a pathway towards scalable integrated CV-QKD transceivers, a vital step towards large-scale QKD networks.

  16. An investigation of DUA caching strategies for public key certificates

    SciTech Connect (OSTI)

    Cheung, T.C.

    1993-11-01

    Internet Privacy Enhanced Mail (PEM) provides security services to users of Internet electronic mail. PEM is designed with the intention that it will eventually obtain public key certificates from the X.500 directory service. However, such a capability is not present in most PEM implementations today. While the prevalent PEM implementation uses a public key certificate-based strategy, certificates are mostly distributed via e-mail exchanges, which raises several security and performance issues. In this thesis research, we changed the reference PEM implementation to make use of the X.500 directory service instead of local databases for public key certificate management. The thesis discusses some problems with using the X.500 directory service, explores the relevant issues, and develops an approach to address them. The approach makes use of a memory cache to store public key certificates. We implemented a centralized cache server and addressed the denial-of-service security problem that is present in the server. In designing the cache, we investigated several cache management strategies. One result of our study is that the use of a cache significantly improves performance. Our research also indicates that security incurs extra performance cost. Different cache replacement algorithms do not seem to yield significant performance differences, while delaying dirty-writes to the backing store does improve performance over immediate writes.

  17. Small Modular Reactors - Key to Future Nuclear Power

    Broader source: Energy.gov (indexed) [DOE]

    Small Modular Reactors - Key to Future Nuclear Power Generation in the U.S. 1,2 Robert Rosner ... b,c Wind (On-shore) 90 9 Solar PV 180 18 Solar Thermal 250 25 Biomass 90-180 9-18 a. ...

  18. Hydrogen Home Refueling: Status, Key Issues, and Challenges

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Electrolytic Hydrogen Production Workshop NREL, Golden, Colorado Hydrogen Home Refueling Status, Ke y Issue s, and Challenges Cortney Mittelsteadt VP, Technology Giner, Inc. February 27-28 th , 2014 89 Rum ford Ave, Newton, Ma. 02466 Based on Forecourt H2A Model (Ver. 3.0) H 2 Production Cost Contribution DOE Target Home Refueler  requirement for H70 hydrogen refu  6,250 psig)     meet 2020 target for H70 ref *M echani cal Com pressor not requi red for H35 refuel i ng. Com

  19. Evolution of Florida Bay islands from a supratidal precursor: evidence from westernmost Bob Allen Key and Sid Key

    SciTech Connect (OSTI)

    Quinn, T.M.; Merriam, D.F.

    1988-05-01

    Cores from the interior portions of westernmost Bob Allen Key and Sid Key document island nucleation from a supratidal precursor developed on a paralic peat deposit; whereas cores from exterior portions of these islands document development of marine mudbanks, progradation or colonization by mangroves, and supratidal sedimentation. The supratidal precursor beneath these islands consists of eroded remnants of coastal tidal flats or local topographic highs that remained supratidal throughout the Holocene sea-level rise. Sedimentologic and biostratigraphic evidence suggest erosion of mangroves by storms or inundation of mangroves by storm deposits is a common precursor to subsequent sediment aggradation on both islands. If other Florida Bay islands develop from mangrove colonization of marine mudbanks, then data from westernmost Bob Allen Key and Sid Key indicate that nucleation from a supratidal precursor and mangrove colonization of marine mudbanks are both viable mechanisms for island initiation. The absence of evidence of a supratidal nucleus beneath an island can result from (a) island migration and subsequent erosion or (b) insufficient sampling density. Stratigraphic data from Florida Bay are insufficient to discriminate between the relative importance of these two models of island evolution; the authors contend that any model of the evolution of Florida Bay islands must incorporate island nucleation from a supratidal precursor as a viable mechanism for island evolution.

  20. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R.; Del Vecchio, Robert M.

    1984-01-01

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reaction accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  1. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R.; Del Vecchio, Robert M.

    1987-01-01

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reactions accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  2. Coherent Communications, Imaging and Targeting

    SciTech Connect (OSTI)

    Stappaerts, E; Baker, K; Gavel, D; Wilks, S; Olivier, S; Brase, J; Olivier, S; Brase, J

    2003-10-03

    Laboratory and field demonstration results obtained as part of the DARPA-sponsored Coherent Communications, Imaging and Targeting (CCIT) program are reviewed. The CCIT concept uses a Phase Conjugation Engine based on a quadrature receiver array, a hologram processor and a spatial light modulator (SLM) for high-speed, digital beam control. Progress on the enabling MEMS SLM, being developed by a consortium consisting of LLNL, academic institutions and small businesses, is presented.

  3. Method for forming electrically charged laser targets

    DOE Patents [OSTI]

    Goodman, Ronald K.; Hunt, Angus L.

    1979-01-01

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  4. Public-key data authentication for treaty verification

    SciTech Connect (OSTI)

    Draelos, T.J.; Goldsmith, S.Y.

    1992-08-01

    A public-key Treaty Data Authentication Module (TDAM) based on the National Institute of Standards and Technology (NIST) Digital Signature Standard (DSS) has been developed to support treaty verification systems. The TDAM utilizes the Motorola DSP56001 Digital Signal Processor as a coprocessor and supports both the STD Bus and PC-AT Bus platforms. The TDAM is embedded within an Authenticated Data Communication Subsystem (ADCS) which provides transparent data authentication and communications, thereby concealing the details of securely authenticating and communicating compliance data and commands. The TDAM has been designed according to the NIST security guidelines for cryptographic modules. Public-key data authentication is important for support of both bilateral and multi-lateral treaties. 8 refs.

  5. Public-key data authentication for treaty verification

    SciTech Connect (OSTI)

    Draelos, T.J.; Goldsmith, S.Y.

    1992-01-01

    A public-key Treaty Data Authentication Module (TDAM) based on the National Institute of Standards and Technology (NIST) Digital Signature Standard (DSS) has been developed to support treaty verification systems. The TDAM utilizes the Motorola DSP56001 Digital Signal Processor as a coprocessor and supports both the STD Bus and PC-AT Bus platforms. The TDAM is embedded within an Authenticated Data Communication Subsystem (ADCS) which provides transparent data authentication and communications, thereby concealing the details of securely authenticating and communicating compliance data and commands. The TDAM has been designed according to the NIST security guidelines for cryptographic modules. Public-key data authentication is important for support of both bilateral and multi-lateral treaties. 8 refs.

  6. Method for adding nodes to a quantum key distribution system

    DOE Patents [OSTI]

    Grice, Warren P

    2015-02-24

    An improved quantum key distribution (QKD) system and method are provided. The system and method introduce new clients at intermediate points along a quantum channel, where any two clients can establish a secret key without the need for a secret meeting between the clients. The new clients perform operations on photons as they pass through nodes in the quantum channel, and participate in a non-secret protocol that is amended to include the new clients. The system and method significantly increase the number of clients that can be supported by a conventional QKD system, with only a modest increase in cost. The system and method are compatible with a variety of QKD schemes, including polarization, time-bin, continuous variable and entanglement QKD.

  7. Secure password-based authenticated key exchange for web services

    SciTech Connect (OSTI)

    Liang, Fang; Meder, Samuel; Chevassut, Olivier; Siebenlist, Frank

    2004-11-22

    This paper discusses an implementation of an authenticated key-exchange method rendered on message primitives defined in the WS-Trust and WS-SecureConversation specifications. This IEEE-specified cryptographic method (AuthA) is proven-secure for password-based authentication and key exchange, while the WS-Trust and WS-Secure Conversation are emerging Web Services Security specifications that extend the WS-Security specification. A prototype of the presented protocol is integrated in the WSRF-compliant Globus Toolkit V4. Further hardening of the implementation is expected to result in a version that will be shipped with future Globus Toolkit releases. This could help to address the current unavailability of decent shared-secret-based authentication options in the Web Services and Grid world. Future work will be to integrate One-Time-Password (OTP) features in the authentication protocol.

  8. A Universal Method for Fishing Target Proteins from Mixtures of Biomolecules using Isothermal Titration Calorimetry

    SciTech Connect (OSTI)

    Zhou, X.; Sun, Q; Kini, R; Sivaraman, J

    2008-01-01

    The most challenging tasks in biology include the identification of (1) the orphan receptor for a ligand, (2) the ligand for an orphan receptor protein, and (3) the target protein(s) for a given drug or a lead compound that are critical for the pharmacological or side effects. At present, several approaches are available, including cell- or animal-based assays, affinity labeling, solid-phase binding assays, surface plasmon resonance, and nuclear magnetic resonance. Most of these techniques are not easy to apply when the target protein is unknown and the compound is not amenable to labeling, chemical modification, or immobilization. Here we demonstrate a new universal method for fishing orphan target proteins from a complex mixture of biomolecules using isothermal titration calorimetry (ITC) as a tracking tool. We took snake venom, a crude mixture of several hundred proteins/peptides, as a model to demonstrate our proposed ITC method in tracking the isolation and purification of two distinct target proteins, a major component and a minor component. Identities of fished out target proteins were confirmed by amino acid sequencing and inhibition assays. This method has the potential to make a significant advancement in the area of identifying orphan target proteins and inhibitor screening in drug discovery and characterization.

  9. NREL Scientists Find Key Function for Ferredoxins in Algae Hydrogen

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Production - News Releases | NREL Scientists Find Key Function for Ferredoxins in Algae Hydrogen Production Two of six iron-rich proteins shown to have role in algae metabolism; discovery could lead to enhanced hydrogen production February 10, 2014 Scientists at the Energy Department's National Renewable Energy Laboratory have demonstrated that just two of six iron-sulfur-containing ferredoxins in a representative species of algae promote electron transfers to and from hydrogenases. The

  10. Researchers find potential key for unlocking biomass energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unlocking biomass energy Researchers find potential key for unlocking biomass energy Potential pretreatment method that can make plant cellulose five times more digestible by enzymes that convert it into ethanol, a useful biofuel. July 20, 2011 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new

  11. Sandia completes major overhaul of key nuclear weapons test facilities |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) completes major overhaul of key nuclear weapons test facilities Tuesday, May 13, 2014 - 2:46pm Sandia National Laboratories recently completed the renovation of five large-scale test facilities that are crucial to ensuring the safety and reliability of the nation's nuclear weapons systems. The work supports Sandia's ongoing nuclear stockpile modernization work on the B61-12 and W88 Alt, assessments of current stockpile systems, and test and

  12. PPPL physicists win supercomputing time to simulate key energy and

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    astrophysical phenomena | Princeton Plasma Physics Lab PPPL physicists win supercomputing time to simulate key energy and astrophysical phenomena By John Greenwald January 8, 2013 Tweet Widget Google Plus One Share on Facebook A donut-shaped plasma simulation that C.S. Chang's center produced on a supercomputer. The orange and blue colors show regions of turbulence. (Photo by Visualization by Prof. Kwan-Liu's group, University of California-Davis) A donut-shaped plasma simulation that C.S.

  13. PPPL physicists win supercomputing time to simulate key energy and

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    astrophysical phenomena | Princeton Plasma Physics Lab physicists win supercomputing time to simulate key energy and astrophysical phenomena By John Greenwald January 8, 2013 Tweet Widget Google Plus One Share on Facebook Gallery: Three teams led by scientists at the U.S. Department of Energy's (DOE) Princeton Plasma Physics Laboratory (PPPL) have won major blocks of time on two of the world's most powerful supercomputers. Two of the projects seek to advance the development of nuclear fusion

  14. Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion Print The burning of fossil fuels and the consequent rising levels of atmospheric CO-2 has led to a number of negative environmental consequences, including global warming and ocean acidification. Converting CO2 to fuels or chemical feedstock, ideally through the use of renewable energy, can simultaneously reduce atmospheric CO2 and decrease fossil fuel consumption. The principal difficulty in this process is that

  15. Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion Print The burning of fossil fuels and the consequent rising levels of atmospheric CO-2 has led to a number of negative environmental consequences, including global warming and ocean acidification. Converting CO2 to fuels or chemical feedstock, ideally through the use of renewable energy, can simultaneously reduce atmospheric CO2 and decrease fossil fuel consumption. The principal difficulty in this process is that

  16. Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion Print The burning of fossil fuels and the consequent rising levels of atmospheric CO-2 has led to a number of negative environmental consequences, including global warming and ocean acidification. Converting CO2 to fuels or chemical feedstock, ideally through the use of renewable energy, can simultaneously reduce atmospheric CO2 and decrease fossil fuel consumption. The principal difficulty in this process is that

  17. High Pressure PEM Electrolysis: Status, Key Issues, and Challenges

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Pressure PEM Electrolysis Status, Key Issues, and Challenges Electrolytic Hydrogen Production Workshop NREL, Golden, Colorado Monjid Hamdan Director of Engineering Giner, Inc. 89 Rumford Ave, Newton, Ma. 02466 February 27-28 th , 2014 Advantages of High Pressure PEM Electrolysis  Eliminates one or more stages of mechanical compression  Reduces system complexity  Lower drying requirements  Low maintenance  No moving parts  No contaminants  Permits hydrogen generation at

  18. President Obama Announces More Key Administration Posts | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy December 10, 2010 - 12:00am Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Peter B. Lyons, Assistant Secretary for Nuclear Energy, Department of Energy Denise E. O'Donnell, Director of the Bureau of Justice Assistance, Department of Justice Stephanie O'Sullivan, Principal Deputy Director of National Intelligence, Directorate of National Intelligence David Shear, Ambassador to the Socialist

  19. Binding Behavior of Dopamine Transporter Key to Understanding Chemical

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reactions in the Brain Binding Behavior of Dopamine Transporter Key to Understanding Chemical Reactions in the Brain Print Most people have heard of adrenaline, the chemical that causes the "fight or flight" reaction in humans. Most people have also heard of the chemical substances cocaine and methamphetamine, which also elicit a particular (perhaps desired) human response. What most people do not know is that the same receptors in the human brain recognize the natural, or

  20. Binding Behavior of Dopamine Transporter Key to Understanding Chemical

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reactions in the Brain Binding Behavior of Dopamine Transporter Key to Understanding Chemical Reactions in the Brain Print Most people have heard of adrenaline, the chemical that causes the "fight or flight" reaction in humans. Most people have also heard of the chemical substances cocaine and methamphetamine, which also elicit a particular (perhaps desired) human response. What most people do not know is that the same receptors in the human brain recognize the natural, or

  1. Binding Behavior of Dopamine Transporter Key to Understanding Chemical

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reactions in the Brain Binding Behavior of Dopamine Transporter Key to Understanding Chemical Reactions in the Brain Print Most people have heard of adrenaline, the chemical that causes the "fight or flight" reaction in humans. Most people have also heard of the chemical substances cocaine and methamphetamine, which also elicit a particular (perhaps desired) human response. What most people do not know is that the same receptors in the human brain recognize the natural, or

  2. APPENDIX E KEY INDIVIDUALS U.S. Environmental Protection Agency

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    APPENDIX E KEY INDIVIDUALS U.S. Environmental Protection Agency Region 10 Washington State Department of Ecology U.S. Department of Energy, RL and ORP Executive Managers Program Manager for the Hanford Project Office (509) 376-8631 Program Manager for the Nuclear Waste Program (509) 372-7950 Assistant Manager for the Central Plateau (509) 373-9971 Assistant Manager for the Office of River Protection, Waste Treatment and Immobilization Plant (509) 376-4941 Assistant Manager for the Office of

  3. President Obama Announces More Key Administration Posts | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy April 17, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced his intent to nominate the following individuals for key administration posts: Christine M. Griffin, Deputy Director of Office of Personnel Management; Kevin Concannon, Under Secretary for Food, Nutrition and Consumer Services, United States Department of Agriculture; Rajiv Shah, Under Secretary for Research, Education, and Economics, United States Department of Agriculture; Michael Nacht,

  4. President Obama Announces More Key Administration Posts | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy December 9, 2009 - 12:00am Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Patricia A. Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, Department of Energy Mari Del Carmen Aponte, Ambassador to the Republic of El Salvador, Department of State Donald E. Booth, Ambassador to the Federal Democratic Republic of Ethiopia, Department of State Larry Persily, Federal

  5. President Obama Announces More Key Administration Posts | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy January 29, 2010 - 12:00am Addthis THE WHITE HOUSE Office of the Press Secretary WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key administration posts: Jeffrey A. Lane, Assistant Secretary for Congressional and Intergovernmental Affairs, Department of Energy Larry Robinson, Assistant Secretary of Commerce (Conservation and Management), NOAA, Department of Commerce Paul Steven Miller, Governor, Board of Governors of the United

  6. President Obama Announces More Key Administration Posts | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy August 2, 2011 - 9:20pm Addthis WASHINGTON - Today, President Barack Obama announced his intent to nominate the following individuals to key Administration posts: Ashton B. Carter - Nominee for Deputy Secretary of Defense, Department of Defense I. Charles McCullough III - Inspector General of the Intelligence Community, Office of the Director of National Intelligence Ernest Mitchell, Jr. - Administrator, United States Fire Administration, Federal Emergency Management Agency,

  7. LANL breaks ground on key sediment control project

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sediment control project LANL breaks ground on key sediment control project Called "grade-control" structures, the approximately $2 million features are up to eight feet high and made of rocks packed tightly into wire enclosures. November 5, 2009 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics

  8. 2015 Key Wind Program and National Laboratory Accomplishments

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Wind Program and National Laboratory Accomplishments 2015 Key Wind Program and National Laboratory Accomplishments | 1 | Powering the Energy Revolution through Wind Evolution The U.S. Department of Energy (DOE) Wind Program is committed to helping the nation secure cost-competitive sources of renewable energy through the development and deployment of innovative wind power technologies. By investing in improvements to wind plant design, technology development, and operation as well as developing

  9. TEC Working Group Topic Groups Rail Key Documents Planning Subgroup |

    Office of Environmental Management (EM)

    Department of Energy Planning Subgroup TEC Working Group Topic Groups Rail Key Documents Planning Subgroup Planning Subgroup Rail Planning Timeline (135.57 KB) Benchmarking Project: AREVA Trip Report (651.92 KB) More Documents & Publications TEC Meeting Summaries - July 2007 Evaluation of Shortline Railroads & SNF/HLW Rail Shipment Inspections Tasked for the Transportation of Spent Nuclear Fuel Federal Railroad Administration

  10. Transformational Energy Action Management (TEAM) Wireless Energy Efficiency Keys Initiative

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    by Transformational Energy Action Management (TEAM) Wireless Energy Efficiency Keys Initiative *Ways of Using Wireless Technology to Help You Reduce Energy Usage at your Facility Together with our industry partners, we strive to: * Accelerate adoption of the many energy-efficient technologies and practices available today * Conduct vigorous technology innovation to radically improve future energy diversity, resource efficiency, and carbon mitigation * Promote a corporate culture of energy

  11. Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion Print The burning of fossil fuels and the consequent rising levels of atmospheric CO-2 has led to a number of negative environmental consequences, including global warming and ocean acidification. Converting CO2 to fuels or chemical feedstock, ideally through the use of renewable energy, can simultaneously reduce atmospheric CO2 and decrease fossil fuel consumption. The principal difficulty in this process is that

  12. Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion Print The burning of fossil fuels and the consequent rising levels of atmospheric CO-2 has led to a number of negative environmental consequences, including global warming and ocean acidification. Converting CO2 to fuels or chemical feedstock, ideally through the use of renewable energy, can simultaneously reduce atmospheric CO2 and decrease fossil fuel consumption. The principal difficulty in this process is that

  13. Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion Print The burning of fossil fuels and the consequent rising levels of atmospheric CO-2 has led to a number of negative environmental consequences, including global warming and ocean acidification. Converting CO2 to fuels or chemical feedstock, ideally through the use of renewable energy, can simultaneously reduce atmospheric CO2 and decrease fossil fuel consumption. The principal difficulty in this process is that

  14. Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Porous Framework Electrocatalysts Are Key to Carbon Dioxide Conversion Print The burning of fossil fuels and the consequent rising levels of atmospheric CO-2 has led to a number of negative environmental consequences, including global warming and ocean acidification. Converting CO2 to fuels or chemical feedstock, ideally through the use of renewable energy, can simultaneously reduce atmospheric CO2 and decrease fossil fuel consumption. The principal difficulty in this process is that

  15. Small Electric Voltage Alters Conductivity in Key Materials

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Electric Voltage Alters Conductivity in Key Materials - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste

  16. SEC L_Attach G_Key Personnel Cost Sheet

    National Nuclear Security Administration (NNSA)

    L, Attachment G - Management Team Cost Sheet Definitions of items to be included in the worksheet Name Title Key Personnel (Y/N) Reimbursable Annual Base Salary Reimbursable Incentive Pay and bonuses Reimbursable Deferred compensation Reimbursable Employer contributions to Employee Stock Ownership Plans (ESOPs) Reimbursable Employer Contributions to Defined Contribution Pension Plans Current Annual Base Salary Current Total Annual Compensation An ESOP is a stock bonus plan designed to invest

  17. NNSA Administrator, Three Lab Directors Tour Key Weapons Facility |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) Administrator, Three Lab Directors Tour Key Weapons Facility May 08, 2014 ALBUQUERQUE, N.M. - The Administrator of the National Nuclear Security Administration (NNSA), Gen. Frank G. Klotz, and the directors of Sandia, Los Alamos, and Lawrence Livermore national laboratories met today in Albuquerque, N.M., and toured a recently-completed facility at Sandia designed to ensure the continued stewardship of the U.S. nuclear deterrent without

  18. Key Parameters Affecting DPF Performance Degradation and Impact on Lifetime

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fuel Economy | Department of Energy Parameters Affecting DPF Performance Degradation and Impact on Lifetime Fuel Economy Key Parameters Affecting DPF Performance Degradation and Impact on Lifetime Fuel Economy Summarizes latest findings on impact of specific parameters affecting ash-related diesel particulate filter performance degradation and information useful to enhance performance and extend service life deer11_sappok.pdf (3.32 MB) More Documents & Publications Characteristics and

  19. Binding Behavior of Dopamine Transporter Key to Understanding Chemical

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reactions in the Brain Binding Behavior of Dopamine Transporter Key to Understanding Chemical Reactions in the Brain Print Most people have heard of adrenaline, the chemical that causes the "fight or flight" reaction in humans. Most people have also heard of the chemical substances cocaine and methamphetamine, which also elicit a particular (perhaps desired) human response. What most people do not know is that the same receptors in the human brain recognize the natural, or

  20. Key management and encryption under the bounded storage model.

    SciTech Connect (OSTI)

    Draelos, Timothy John; Neumann, William Douglas; Lanzone, Andrew J.; Anderson, William Erik

    2005-11-01

    There are several engineering obstacles that need to be solved before key management and encryption under the bounded storage model can be realized. One of the critical obstacles hindering its adoption is the construction of a scheme that achieves reliable communication in the event that timing synchronization errors occur. One of the main accomplishments of this project was the development of a new scheme that solves this problem. We show in general that there exist message encoding techniques under the bounded storage model that provide an arbitrarily small probability of transmission error. We compute the maximum capacity of this channel using the unsynchronized key-expansion as side-channel information at the decoder and provide tight lower bounds for a particular class of key-expansion functions that are pseudo-invariant to timing errors. Using our results in combination with Dziembowski et al. [11] encryption scheme we can construct a scheme that solves the timing synchronization error problem. In addition to this work we conducted a detailed case study of current and future storage technologies. We analyzed the cost, capacity, and storage data rate of various technologies, so that precise security parameters can be developed for bounded storage encryption schemes. This will provide an invaluable tool for developing these schemes in practice.

  1. Forensic Drug Testing Custody and Control Form

    Broader source: Energy.gov [DOE]

    Forensic Drug Testing Custody and Control Form. A copy of the drug testing custody and control form for DOE contractors to use to comply with the drug testing requirements in 10 CFR part 707, Workplace Substance Abuse Programs at DOE Sites.

  2. TEC Working Group Topic Groups Manual Review Key Documents | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Manual Review Key Documents TEC Working Group Topic Groups Manual Review Key Documents Key Documents Transportation Practices Manual (DOE M 460) - March 8, 2006 (438.51 KB) More Documents & Publications DOE Shipment Activities: What We Accomplished and a Look Forward TEC Working Group Topic Groups Section 180(c) Key Documents TEC Working Group Topic Groups Rail Key Documents

  3. LIFE Target Fabrication Research Plan Sept 2008

    SciTech Connect (OSTI)

    Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

    2008-11-10

    The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

  4. Non-PGM Target Update

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Tech Team Meeting, February 12 th , 2014 1 Compiled for Fuel Cell Tech Team Meeting, March 12 th , 2014 Non-PGM Target Update Piotr Zelenay Materials Physics and Applications Division Los Alamos National Laboratory, Los Alamos, New Mexico 87545 Fuel Cell Tech Team Meeting, February 12 th , 2014 2 Joint CWG/DWG Meeting, Golden, CO, December 18 th , 2013 - Agenda 10:30 am Welcome & introductions 10:40 am Relevance of RDE measurements of catalyst activity and durability to performance in an MEA

  5. Cascaded target normal sheath acceleration

    SciTech Connect (OSTI)

    Wang, W. P.; Shen, B. F.; Zhang, X. M.; Wang, X. F.; Xu, J. C.; Zhao, X. Y.; Yu, Y. H.; Yi, L. Q.; Shi, Y.; Zhang, L. G.; Xu, T. J.; Xu, Z. Z.

    2013-11-15

    A cascaded target normal sheath acceleration (TNSA) scheme is proposed to simultaneously increase energy and improve energy spread of a laser-produced mono-energetic proton beam. An optimum condition that uses the maximum sheath field to accelerate the center of the proton beam is theoretically found and verified by two-dimensional particle-in-cell simulations. An initial 10 MeV proton beam is accelerated to 21 MeV with energy spread decreased from 5% to 2% under the optimum condition during the process of the cascaded TNSA. The scheme opens a way to scale proton energy lineally with laser energy.

  6. Drug Retention Times (Technical Report) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Country of Publication: United States Language: English Subject: 60 APPLIED LIFE SCIENCES; RETENTION; DRUG ABUSE; DRUGS; CRIME DETECTION drugs, retention Word Cloud More Like This ...

  7. Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel ...

  8. Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery

    SciTech Connect (OSTI)

    Mhlanga, Nikiwe; Ray, Suprakas Sinha

    2015-05-22

    Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.

  9. Evaluating Moving Target Defense with PLADD

    SciTech Connect (OSTI)

    Jones, Stephen T.; Outkin, Alexander V.; Gearhart, Jared Lee; Hobbs, Jacob Aaron; Siirola, John Daniel; Phillips, Cynthia A.; Verzi, Stephen Joseph; Tauritz, Daniel; Mulder, Samuel A.; Naugle, Asmeret Bier

    2015-09-15

    This project evaluates the effectiveness of moving target defense (MTD) techniques using a new game we have designed, called PLADD, inspired by the game FlipIt [28]. PLADD extends FlipIt by incorporating what we believe are key MTD concepts. We have analyzed PLADD and proven the existence of a defender strategy that pushes a rational attacker out of the game, demonstrated how limited the strategies available to an attacker are in PLADD, and derived analytic expressions for the expected utility of the game’s players in multiple game variants. We have created an algorithm for finding a defender’s optimal PLADD strategy. We show that in the special case of achieving deterrence in PLADD, MTD is not always cost effective and that its optimal deployment may shift abruptly from not using MTD at all to using it as aggressively as possible. We believe our effort provides basic, fundamental insights into the use of MTD, but conclude that a truly practical analysis requires model selection and calibration based on real scenarios and empirical data. We propose several avenues for further inquiry, including (1) agents with adaptive capabilities more reflective of real world adversaries, (2) the presence of multiple, heterogeneous adversaries, (3) computational game theory-based approaches such as coevolution to allow scaling to the real world beyond the limitations of analytical analysis and classical game theory, (4) mapping the game to real-world scenarios, (5) taking player risk into account when designing a strategy (in addition to expected payoff), (6) improving our understanding of the dynamic nature of MTD-inspired games by using a martingale representation, defensive forecasting, and techniques from signal processing, and (7) using adversarial games to develop inherently resilient cyber systems.

  10. Decoy-state quantum key distribution using homodyne detection

    SciTech Connect (OSTI)

    Shams Mousavi, S. H.; Gallion, P.

    2009-07-15

    In this paper, we propose to use the decoy-state technique to improve the security of the quantum key distribution (QKD) systems based on homodyne detection against the photon number splitting attack. The decoy-state technique is a powerful tool that can significantly boost the secure transmission range of the QKD systems. However, it has not yet been applied to the systems that use homodyne detection. After adapting this theory to the systems based on homodyne detection, we quantify the secure performance and transmission range of the resulting system.

  11. Investing in Oil and Natural Gas A Few Key Issues

    U.S. Energy Information Administration (EIA) Indexed Site

    Strategic Advisors in Global Energy Strategic Advisors in Global Energy Strategic Advisors in Global Energy Investing in Oil and Natural Gas: A Few Key Issues Prepared for EIA Conference Susan Farrell, Senior Director PFC Energy April 8, 2009 Investing in Oil and Gas| PFC Energy| Page 2 The Top 20 IOCs and Top 20 NOCs Account for Over Half of E&P Spend Source: PFC Energy, Global E&P Surveys Investing in Oil and Gas| PFC Energy| Page 3 Oil Prices Rose, But So Did Costs + 52% $0 $20 $40

  12. Membranes Key to Biorefinery Success | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Miming living organisms processes for biorefineries Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Tumblr (Opens in new window) Miming living organisms processes for biorefineries Jimmy Lopez 2015.09.10 Membranes play a key role in the human body, filtering out bacteria and viruses and also ensuring cells absorb essential nutrients. They are

  13. Renewable: A key component of our global energy future

    SciTech Connect (OSTI)

    Hartley, D.

    1995-12-31

    Inclusion of renewable energy sources in national and international energy strategies is a key component of a viable global energy future. The global energy balance is going to shift radically in the near future brought about by significant increases in population in China and India, and increases in the energy intensity of developing countries. To better understand the consequences of such global shifts in energy requirements and to develop appropriate energy strategies to respond to these shifts, we need to look at the factors driving choices among supply options by geopolitical consumers and the impact these factors can have on the future energy mix.

  14. Microsoft Word - fact sheet alternatives and key findings 090214.docx

    National Nuclear Security Administration (NNSA)

    Alternatives and Key Findings of the Draft SEIS ALTERNATIVES The Draft SEIS evaluates a range of reactor site and tritium production capacity alternatives. Seven alternatives are analyzed in the Draft SEIS:  Alternative 1 Watts Bar site only (2,500 TPBARs maximum). This is the preferred alternative.  Alternative 2 Sequoyah site only (2,500 TPBARs maximum).  Alternative 3 Both Watts Bar and Sequoyah sites (2,500 TPBARs maximum).  Alternative 4 Watts Bar site only (5,000 TPBARs

  15. Numerical analysis of decoy state quantum key distribution protocols

    SciTech Connect (OSTI)

    Harrington, Jim W; Rice, Patrick R

    2008-01-01

    Decoy state protocols are a useful tool for many quantum key distribution systems implemented with weak coherent pulses, allowing significantly better secret bit rates and longer maximum distances. In this paper we present a method to numerically find optimal three-level protocols, and we examine how the secret bit rate and the optimized parameters are dependent on various system properties, such as session length, transmission loss, and visibility. Additionally, we show how to modify the decoy state analysis to handle partially distinguishable decoy states as well as uncertainty in the prepared intensities.

  16. Targets for the APEX experiment at ATLAS

    SciTech Connect (OSTI)

    Greene, J.P.; Thomas, G.E.; Leonard, R.H.

    1994-12-31

    Targets of lead, tantalum, thorium and uranium have been produced for experiments with the APEX (Argonne Positron Experiment) apparatus at ATLAS (Argonne Tandem Linac Accelerator System). APEX is a device built at Argonne National Laboratory to investigate the anomalous positrons observed in collisions of very heavy ion beams on heavy targets. Both fixed and rotating targets have been used. The rotating target system involves a 4-quadrant wheel rotating at speeds up to 700 rpm with the position encoded into the data stream. In addition to the hundreds of targets produced for the heavy-ion reactions studied, a wide variety of targets were employed for beam diagnostics, detector calibration and target wheel development. The experiment used very heavy ion beams ({sup 238}U, {sup 206}Pb and {sup 208}Pb) from ATLAS and targets of {sup 206}Pb, {sup 208}Pb, {sup 232}Th and {sup 238}U produced in the laboratory.

  17. Target GmbH | Open Energy Information

    Open Energy Info (EERE)

    navigation, search Name: Target GmbH Place: Germany Sector: Efficiency, Solar Product: German company with interests in solar and energy efficiency. References: Target GmbH1 This...

  18. Cryogenic target system for hydrogen layering

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Parham, T.; Kozioziemski, B.; Atkinson, D.; Baisden, P.; Bertolini, L.; Boehm, K; Chernov, A.; Coffee, K.; Coffield, F.; Dylla-Spears, R.; et al

    2015-11-24

    Here, a cryogenic target positioning system was designed and installed on the National Ignition Facility (NIF) target chamber. This instrument incorporates the ability to fill, form, and characterize the NIF targets with hydrogen isotopes needed for ignition experiments inside the NIF target bay then transport and position them in the target chamber. This effort brought to fruition years of research in growing and metrologizing high-quality hydrogen fuel layers and landed it in an especially demanding operations environment in the NIF facility. D-T (deuterium-tritium) layers for NIF ignition experiments have extremely tight specifications and must be grown in a very highlymore » constrained environment: a NIF ignition target inside a cryogenic target positioner inside the NIF target bay. Exquisite control of temperature, pressure, contaminant level, and thermal uniformity are necessary throughout seed formation and layer growth to create an essentially-groove-free single crystal layer.« less

  19. Targets and processes for fabricating same

    DOE Patents [OSTI]

    Adams, Jesse D; Malekos, Steven; Le Galloudec, Nathalie; Korgan, Grant; Cowan, Thomas; Sentoku, Yasuhiko

    2016-05-17

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  20. Targets and processes for fabricating same

    DOE Patents [OSTI]

    Cowna, Thomas; Malekos, Steven; Korgan, Grant; Adams, Jesse; Sentoku, Yasuhiko; LeGalloudec, Nathalie

    2014-06-10

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  1. Enterprise Assessments Targeted Review, Argonne National Laboratory...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The targeted review of ANL was performed during the period from April 7-25, 2014. Enterprise Assessments Targeted Review, Argonne National Laboratory - November 2014 (212.44 KB) ...

  2. Targets and processes for fabricating same

    DOE Patents [OSTI]

    Cowan, Thomas; Malekos, Steven; Korgan, Grant; Adams, Jesse; Sentoku, Yasuhiko; Le Galloudec, Nathalie; Fuchs, Julien

    2012-07-24

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  3. Sandia Energy - Key Hydrogen Report Now Available on OpenEnergyInfo...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Hydrogen Report Now Available on OpenEnergyInfo Wiki Site Home Energy CRF Facilities News Energy Efficiency News & Events Systems Analysis Systems Engineering Key Hydrogen...

  4. U-027: RSA Key Manager Appliance Session Logout Bug Fails to...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PROBLEM: RSA Key Manager Appliance Session Logout Bug Fails to Terminate Sessions. PLATFORM: RSA Key Manager Appliance 2.7 Service Pack 1 ABSTRACT: A remote authenticated...

  5. Radioactive targets for neutron-induced cross section measurements

    SciTech Connect (OSTI)

    Kronenberg, A.; Bond, E. M.; Glover, S. E.; Rundberg, R. S.; Vieira, D. J.; Esch, E. I.; Reifarth, R.; Ullmann, J. L.; Haight, Robert C.; Rochmann, D.

    2004-01-01

    Measurements using radioactive targets are important for the determination of key reaction path ways associated with the synthesis of the elements in nuclear astrophysics (sprocess), advanced fuel cycle initiative (transmutation of radioactive waste), and stockpile stewardship. High precision capture cross-section measurements are needed to interpret observations, predict elemental or isotopical ratios, and unobserved abundances. There are two new detector systems that are presently being commissioned at Los Alamos National Laboratory for very precise measurements of (n,{gamma}) and (n,f) cross-sections using small quantities of radioactive samples. DANCE (Detector for Advanced Neutron-Capture Experiments), a 4 {pi} gamma array made up of 160 BaF{sub 2} detectors, is designed to measure neutron capture cross-sections of unstable nuclei in the low-energy range (thermal to {approx}500 keV). The high granularity and high detection efficiency of DANCE, combined with the high TOF-neutron flux available at the Lujan Center provides a versatile tool for measuring many important cross section data using radioactive and isotopically enriched targets of about 1 milligram. Another powerful instrument is the Lead-slowing down spectrometer (LSDS), which will enable the measurement of neutron-induced fission cross-section of U-235m and other short-lived actinides in a energy range from 1-200 keV with sample sizes down to 10 nanograms. Due to the short half-life of the U-235m isomer (T{sub 1/2} = 26 minutes), the samples must be rapidly and repeatedly extracted from its {sup 239}Pu parent. Since {sup 239}Pu is itself highly fissile, the separation must not only be rapid, but must also be of very high purity (the Pu must be removed from the U with a decontamination factor >10{sup 12}). Once extracted and purified, the {sup 235m}U isomer would be electrodeposited on solar cells as a fission detector and placed within the LSDS for direct (n,f) cross section measurements. The

  6. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar; Jani, Dewal; Nagarkatti, Rana

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  7. Fabrication of boron sputter targets

    DOE Patents [OSTI]

    Makowiecki, Daniel M.; McKernan, Mark A.

    1995-01-01

    A process for fabricating high density boron sputtering targets with sufficient mechanical strength to function reliably at typical magnetron sputtering power densities and at normal process parameters. The process involves the fabrication of a high density boron monolithe by hot isostatically compacting high purity (99.9%) boron powder, machining the boron monolithe into the final dimensions, and brazing the finished boron piece to a matching boron carbide (B.sub.4 C) piece, by placing aluminum foil there between and applying pressure and heat in a vacuum. An alternative is the application of aluminum metallization to the back of the boron monolithe by vacuum deposition. Also, a titanium based vacuum braze alloy can be used in place of the aluminum foil.

  8. Fabrication of boron sputter targets

    DOE Patents [OSTI]

    Makowiecki, D.M.; McKernan, M.A.

    1995-02-28

    A process is disclosed for fabricating high density boron sputtering targets with sufficient mechanical strength to function reliably at typical magnetron sputtering power densities and at normal process parameters. The process involves the fabrication of a high density boron monolithe by hot isostatically compacting high purity (99.9%) boron powder, machining the boron monolithe into the final dimensions, and brazing the finished boron piece to a matching boron carbide (B{sub 4}C) piece, by placing aluminum foil there between and applying pressure and heat in a vacuum. An alternative is the application of aluminum metallization to the back of the boron monolithe by vacuum deposition. Also, a titanium based vacuum braze alloy can be used in place of the aluminum foil. 7 figs.

  9. Terahertz-based target typing.

    SciTech Connect (OSTI)

    Lyo, Sungkwun Kenneth; Wanke, Michael Clement; Reno, John Louis; Shaner, Eric Arthur; Grine, Albert D.; Barrick, Todd A.

    2008-09-01

    The purpose of this work was to create a THz component set and understanding to aid in the rapid analysis of transient events. This includes the development of fast, tunable, THz detectors, along with filter components for use with standard detectors and accompanying models to simulate detonation signatures. The signature effort was crucial in order to know the spectral range to target for detection. Our approach for frequency agile detection was to utilize plasmons in the channel of a specially designed field-effect transistor called the grating-gate detector. Grating-gate detectors exhibit narrow-linewidth, broad spectral tunability through application of a gate bias, and no angular dependence in their photoresponse. As such, if suitable sensitivity can be attained, they are viable candidates for Terahertz multi-spectral focal plane arrays.

  10. Synchronous identification of friendly targets

    DOE Patents [OSTI]

    Telle, John M.; Roger, Stutz A.

    1998-01-01

    A synchronous communication targeting system for use in battle. The present invention includes a transceiver having a stabilizing oscillator, a synchronous amplifier and an omnidirectional receiver, all in electrical communication with each other. A remotely located beacon is attached to a blackbody radiation source and has an amplitude modulator in electrical communication with a optical source. The beacon's amplitude modulator is set so that the optical source transmits radiation frequency at approximately the same or lower amplitude than that of the blackbody radiation source to which the beacon is attached. The receiver from the transceiver is adapted to receive frequencies approximately at or below blackbody radiation signals and sends such signals to the synchronous amplifier. The synchronous amplifier then rectifies and amplifies those signals which correspond to the predetermined frequency to therefore identify whether the blackbody radiation source is friendly or not.

  11. An electromagnetic induction method for underground target detection and characterization

    SciTech Connect (OSTI)

    Bartel, L.C.; Cress, D.H.

    1997-01-01

    An improved capability for subsurface structure detection is needed to support military and nonproliferation requirements for inspection and for surveillance of activities of threatening nations. As part of the DOE/NN-20 program to apply geophysical methods to detect and characterize underground facilities, Sandia National Laboratories (SNL) initiated an electromagnetic induction (EMI) project to evaluate low frequency electromagnetic (EM) techniques for subsurface structure detection. Low frequency, in this case, extended from kilohertz to hundreds of kilohertz. An EMI survey procedure had already been developed for borehole imaging of coal seams and had successfully been applied in a surface mode to detect a drug smuggling tunnel. The SNL project has focused on building upon the success of that procedure and applying it to surface and low altitude airborne platforms. Part of SNL`s work has focused on improving that technology through improved hardware and data processing. The improved hardware development has been performed utilizing Laboratory Directed Research and Development (LDRD) funding. In addition, SNL`s effort focused on: (1) improvements in modeling of the basic geophysics of the illuminating electromagnetic field and its coupling to the underground target (partially funded using LDRD funds) and (2) development of techniques for phase-based and multi-frequency processing and spatial processing to support subsurface target detection and characterization. The products of this project are: (1) an evaluation of an improved EM gradiometer, (2) an improved gradiometer concept for possible future development, (3) an improved modeling capability, (4) demonstration of an EM wave migration method for target recognition, and a demonstration that the technology is capable of detecting targets to depths exceeding 25 meters.

  12. Revealing a steroid receptor ligand as a unique PPAR[gamma] agonist...

    Office of Scientific and Technical Information (OSTI)

    regulates metabolic homeostasis and is a molecular target for anti-diabetic drugs. ... Similar to rosiglitazone, RU-486 modulates the expression of key PPARgamma target genes ...

  13. Key Response Planning Factors for the Aftermath of Nuclear Terrorism

    SciTech Connect (OSTI)

    Buddemeier, B R; Dillon, M B

    2009-01-21

    Despite hundreds of above-ground nuclear tests and data gathered from Hiroshima and Nagasaki, the effects of a ground-level, low-yield nuclear detonation in a modern urban environment are still the subject of considerable scientific debate. Extensive review of nuclear weapon effects studies and discussions with nuclear weapon effects experts from various federal agencies, national laboratories, and technical organizations have identified key issues and bounded some of the unknowns required to support response planning for a low-yield, ground-level nuclear detonation in a modern U.S. city. This study, which is focused primarily upon the hazards posed by radioactive fallout, used detailed fallout predictions from the advanced suite of three-dimensional (3-D) meteorology and plume/fallout models developed at Lawrence Livermore National Laboratory (LLNL), including extensive global Key Response Planning Factors for the Aftermath of Nuclear Terrorism geographical and real-time meteorological databases to support model calculations. This 3-D modeling system provides detailed simulations that account for complex meteorology and terrain effects. The results of initial modeling and analysis were presented to federal, state, and local working groups to obtain critical, broad-based review and feedback on strategy and messaging. This effort involved a diverse set of communities, including New York City, National Capitol Regions, Charlotte, Houston, Portland, and Los Angeles. The largest potential for reducing casualties during the post-detonation response phase comes from reducing exposure to fallout radiation. This can be accomplished through early, adequate sheltering followed by informed, delayed evacuation.B The response challenges to a nuclear detonation must be solved through multiple approaches of public education, planning, and rapid response actions. Because the successful response will require extensive coordination of a large number of organizations, supplemented by

  14. PLUTONIUM-238 PRODUCTION TARGET DESIGN STUDIES

    SciTech Connect (OSTI)

    Hurt, Christopher J [ORNL; Wham, Robert M [ORNL; Hobbs, Randall W [ORNL; Owens, R Steven [ORNL; Chandler, David [ORNL; Freels, James D [ORNL; Maldonado, G Ivan [ORNL

    2014-01-01

    A new supply chain is planned for plutonium-238 using existing reactors at the Oak Ridge National Laboratory (ORNL) and Idaho National Laboratory (INL) and existing chemical recovery facilities at ORNL. Validation and testing activities for new irradiation target designs have been conducted in three phases over a 2 year period to provide data for scale-up to production. Target design, qualification, target fabrication, and irradiation of fully-loaded targets have been accomplished. Data from post-irradiation examination (PIE) supports safety analysis and irradiation of future target designs.

  15. Free-space quantum key distribution at night

    SciTech Connect (OSTI)

    Buttler, W.T.; Hughes, R.J.; Kwiat, P.G.; Lamoreaux, S.K.; Luther, G.G.; Morgan, G.L.; Nordholt, J.E.; Peterson, C.G.; Simmons, C.M.

    1998-09-01

    An experimental free-space quantum key distribution (QKD) system has been tested over an outdoor optical path of {approximately} 1 km under nighttime conditions at Los Alamos National Laboratory. This system employs the Bennett 92 protocol; in this paper, the authors give a brief overview of this protocol, and describe the experimental implementation of it. An analysis of the system efficiency is presented, as well as a description of the error detection protocol which employs a two-dimensional parity check scheme. Finally, the susceptibility of this system to eavesdropping by various techniques is determined, and the effectiveness of privacy amplification procedures is discussed. The conclusions are that free-space QKD is both effective and secure; possible applications include the rekeying of satellites in low earth orbit.

  16. Breast cancer drugs dampen vascular functions by interfering with nitric oxide signaling in endothelium

    SciTech Connect (OSTI)

    Gajalakshmi, Palanivel; Priya, Mani Krishna; Pradeep, Thangaraj; Behera, Jyotirmaya; Muthumani, Kandasamy; Madhuwanti, Srinivasan; Saran, Uttara; Chatterjee, Suvro

    2013-06-01

    Widely used chemotherapeutic breast cancer drugs such as Tamoxifen citrate (TC), Capecitabine (CP) and Epirubicin (EP) are known to cause various cardiovascular side-effects among long term cancer survivors. Vascular modulation warrants nitric oxide (NO) signal transduction, which targets the vascular endothelium. We hypothesize that TC, CP and EP interference with the nitric oxide downstream signaling specifically, could lead to cardiovascular dysfunctions. The results demonstrate that while all three drugs attenuate NO and cyclic guanosine mono-phosphate (cGMP) production in endothelial cells, they caused elevated levels of NO in the plasma and RBC. However, PBMC and platelets did not show any significant changes under treatment. This implies that the drug effects are specific to the endothelium. Altered eNOS and phosphorylated eNOS (Ser-1177) localization patterns in endothelial cells were observed following drug treatments. Similarly, the expression of phosphorylated eNOS (Ser-1177) protein was decreased under the treatment of drugs. Altered actin polymerization was also observed following drug treatment, while addition of SpNO and 8Br-cGMP reversed this effect. Incubation with the drugs decreased endothelial cell migration whereas addition of YC-1, SC and 8Br-cGMP recovered the effect. Additionally molecular docking studies showed that all three drugs exhibited a strong binding affinity with the catalytic domain of human sGC. In conclusion, results indicate that TC, CP and EP cause endothelial dysfunctions via the NOsGCcGMP pathway and these effects could be recovered using pharmaceutical agonists of NO signaling pathway. Further, the study proposes a combination therapy of chemotherapeutic drugs and cGMP analogs, which would confer protection against chemotherapy mediated vascular dysfunctions in cancer patients. - Highlights: NO production is reduced in endothelial cells under breast cancer drug treatment. Cellular cGMP level is decreased under the

  17. Target Fabrication: A View from the Users

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Barnes, Cris W.; Batha, Steven H.; Christensen, Cindy R.; Cobble, James A.; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael; Swift, Damian; Workman, Jonathan

    2004-03-15

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  18. TARGET FABRICATION: A VIEW FROM THE USERS.

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Batha, Steven H.; Barnes, Cris W.; Christensen, Cindy; Cobble, James; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael S.; Swift, Damian; Workman, Jonathan

    2003-07-18

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in time to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  19. Ignition of deuterium-trtium fuel targets

    DOE Patents [OSTI]

    Musinski, Donald L.; Mruzek, Michael T.

    1991-01-01

    A method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom.

  20. Ignition of deuterium-tritium fuel targets

    DOE Patents [OSTI]

    Musinski, D.L.; Mruzek, M.T.

    1991-08-27

    Disclosed is a method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom. 5 figures.

  1. SU-F-19A-08: Optimal Time Release Schedule of In-Situ Drug Release During Permanent Prostate Brachytherapy

    SciTech Connect (OSTI)

    Cormack, R; Ngwa, W; Makrigiorgos, G; Tangutoori, S; Rajiv, K; Sridhar, S

    2014-06-15

    Purpose: Permanent prostate brachytherapy spacers can be used to deliver sustained doses of radiosentitizing drug directly to the target, in order to enhance the radiation effect. Implantable nanoplatforms for chemo-radiation therapy (INCeRTs) have a maximum drug capacity and can be engineered to control the drug release schedule. The optimal schedule for sensitization during continuous low dose rate irradiation is unknown. This work studies the optimal release schedule of drug for both traditional sensitizers, and those that work by suppressing DNA repair processes. Methods: Six brachytherapy treatment plans were used to model the anatomy, implant geometry and calculate the spatial distribution of radiation dose and drug concentrations for a range of drug diffusion parameters. Three state partial differential equations (cells healthy, damaged or dead) modeled the effect of continuous radiation (radiosensitivities ?,?) and cellular repair (time tr) on a cell population. Radiosensitization was modeled as concentration dependent change in ?,? or tr which with variable duration under the constraint of fixed total drug release. Average cell kill was used to measure effectiveness. Sensitization by means of both enhanced damage and reduced repair were studied. Results: Optimal release duration is dependent on the concentration of radiosensitizer compared to the saturation concentration (csat) above which additional sensitization does not occur. Long duration drug release when enhancing ? or ? maximizes cell death when drug concentrations are generally over csat. Short term release is optimal for concentrations below saturation. Sensitization by suppressing repair has a similar though less distinct trend that is more affected by the radiation dose distribution. Conclusion: Models of sustained local radiosensitization show potential to increase the effectiveness of radiation in permanent prostate brachytherapy. INCeRTs with high drug capacity produce the greatest benefit

  2. Neuroimaging for drug addiction and related behaviors

    SciTech Connect (OSTI)

    Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

    2011-10-01

    In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

  3. TEC Working Group Topic Groups Routing Key Documents | Department of Energy

    Office of Environmental Management (EM)

    Key Documents TEC Working Group Topic Groups Routing Key Documents KEY DOCUMENTS Proposed Task Plan - Routing Topic Group (53.69 KB) More Documents & Publications TEC Working Group Topic Groups Routing Conference Call Summaries TEC Working Group Topic Groups Rail Key Documents TEC Meeting Summaries - September 2006

  4. Quantum mechanical approaches to in silico enzyme characterization and drug design

    SciTech Connect (OSTI)

    Nilmeier, J P; Fattebert, J L; Jacobson, M P; Kalyanaraman, C

    2012-01-17

    The astonishing, exponentially increasing rates of genome sequencing has led to one of the most significant challenges for the biological and computational sciences in the 21st century: assigning the likely functions of the encoded proteins. Enzymes represent a particular challenge, and a critical one, because the universe of enzymes is likely to contain many novel functions that may be useful for synthetic biology, or as drug targets. Current approaches to protein annotation are largely based on bioinformatics. At the simplest level, this annotation involves transferring the annotations of characterized enzymes to related sequences. In practice, however, there is no simple, sequence based criterion for transferring annotations, and bioinformatics alone cannot propose new enzymatic functions. Structure-based computational methods have the potential to address these limitations, by identifying potential substrates of enzymes, as we and others have shown. One successful approach has used in silico 'docking' methods, more commonly applied in structure-based drug design, to identify possible metabolite substrates. A major limitation of this approach is that it only considers substrate binding, and does not directly assess the potential of the enzyme to catalyze a particular reaction using a particular substrate. That is, substrate binding affinity is necessary but not sufficient to assign function. A reaction profile is ultimately what is needed for a more complete quantitative description of function. To address this rather fundamental limitation, they propose to use quantum mechanical methods to explicitly compute transition state barriers that govern the rates of catalysis. Although quantum mechanical, and mixed quantum/classical (QM/MM), methods have been used extensively to investigate enzymatic reactions, the focus has been primarily on elucidating complex reaction mechanisms. Here, the key catalytic steps are known, and they use these methods quantify substrate

  5. Tensor Target Polarization at TRIUMF

    SciTech Connect (OSTI)

    Smith, G

    2014-10-27

    The first measurements of tensor observables in $\\pi \\vec{d}$ scattering experiments were performed in the mid-80's at TRIUMF, and later at SIN/PSI. The full suite of tensor observables accessible in $\\pi \\vec{d}$ elastic scattering were measured: $T_{20}$, $T_{21}$, and $T_{22}$. The vector analyzing power $iT_{11}$ was also measured. These results led to a better understanding of the three-body theory used to describe this reaction. %Some measurements were also made in the absorption and breakup channels. A direct measurement of the target tensor polarization was also made independent of the usual NMR techniques by exploiting the (nearly) model-independent result for the tensor analyzing power at 90$^\\circ _{cm}$ in the $\\pi \\vec{d} \\rightarrow 2p$ reaction. This method was also used to check efforts to enhance the tensor polarization by RF burning of the NMR spectrum. A brief description of the methods developed to measure and analyze these experiments is provided.

  6. Emerging pathogens: Dynamics, mutation and drug resistance

    SciTech Connect (OSTI)

    Perelson, A.S.; Goldstein, B.; Korber, B.T.

    1997-10-01

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objectives of this project were to develop models of the spread of pathogens, such as HIV-1 and influenza, in humans, and then to use the models to address the possibility of designing appropriate drug therapies that may limit the ability of the pathogen to escape treatment by mutating into a drug resistant form. We have developed a model of drug-resistance to amantidine and rimantadine, the two major antiviral drugs used to treat influenza, and have used the model to suggest treatment strategies during an epidemic.

  7. Science@SLAC—Discovering New Drugs

    SciTech Connect (OSTI)

    Drell, Persis; Smith, Clyde; Bushnell, Dave

    2011-10-18

    SLAC scientists and private-sector drug makers describe how a public--private partnership combined with the specialized X-rays from the Stanford Synchrotron Radiation Lightsource (SSRL) enable smart drug design that eliminates the costly trial-and-error approach used by traditional drug companies. SSRL is a synchrotron lightsource laboratory used by scientists from a range of disciplines to study matter on the scale of atoms and molecules. Featured in this video are SLAC Laboratory Director Persis Drell, SSRL staff scientist Clyde Smith, and Dave Bushnell, a scientist from startup drug maker Cocrystal Discovery Inc.

  8. Thin-thick hydrogen target for nuclear physics

    SciTech Connect (OSTI)

    Gheller, J.-M.; Juster, F.-P.; Authelet, G.; Relland, J.

    2014-01-29

    In spectroscopic studies of unstable nuclei, hydrogen targets are of key importance. The CHyMENE Project aims to provide to the nuclear physics community a thin and pure solid windowless hydrogen or deuterium target. CHyMENE project must respond to this request for the production of solid Hydrogen. The solid hydrogen target is produced in a continuous flow (1 cm/s) by an extrusion technique (developed with the PELIN laboratory) in a vacuum chamber. The shape of the target is determined by the design of the nozzle at the extrusion process. For the purpose, the choice is a rectangular shape with a width of 10 mm and a thickness in the range of 30-50 microns necessary for the physics objectives. The cryostat is equipped with a GM Cryocooler with sufficient power for the solidification of the hydrogen in the lower portion of the extruder. In the higher part of the cryostat, the hydrogen gas is first liquefied and partially solidified. It is then compressed at 100 bars in the cooled extruder before expulsion of the film through the nozzle at the center of the reaction vacuum chamber. After the previous step, the solid hydrogen ribbon falls by gravity into a dedicated chamber where it sublimes and the gas is pumped and evacuated in a exhaust line. This paper deals with the design of the cryostat with its equipment, with the sizing of the thermal bridge (Aluminum and copper), with the results regarding the contact resistance as well as with the vacuum computations of the reaction and recovery hydrogen gas chambers.

  9. Target injection methods for inertial fusion energy

    SciTech Connect (OSTI)

    Petzoldt, R.W.; Moir, R.W.

    1994-06-01

    We have studied four methods to inject IFE targets: the gas gun, electrostatic accelerator, induction accelerator, and rail gun. We recommend a gas gun for indirect drive targets because they can support a gas pressure load on one end and can slide along the gun barrel without damage. With the gas gun, the amount of gas required for each target (about 10 to 100 mg) is acceptable; for other types of targets, a sabot would be necessary. A cam and poppet valve arrangement is recommended for gas flow control. An electrostatic accelerator is attractive for use with lightweight spherical direct drive targets. Since there is no physical contact between the target and the injector, there will be no wear of either component during the injection process. An induction accelerator has an advantage of no electrical contact between the target and the injector. Physical contact is not even necessary, so the wear should be minimal. It requires a cylindrical conductive target sleeve which is a substantial added mass. A rail gun is a simpler device than an electrostatic accelerator or induction accelerator. It requires electrical contact between the target and the rails and may have a significant wear rate. The wear in a vacuum could be reduced by use of a solid lubricant such as MoS{sub 2}. The total required accuracy of target injection, tracking and beam pointing of {plus_minus}0.4 mm appears achievable but will require development and experimental verification.

  10. 3 MW Solid Rotating Target Design

    SciTech Connect (OSTI)

    McManamy, Thomas J; Gallmeier, Franz X; Rennich, Mark J; Ferguson, Phillip D; Janney, Jim G

    2010-01-01

    A rotating solid target design concept is being developed for potential use at the second SNS target station (STS). A long pulse beam (~ 1 msec) at 1.3 GeV and 20 Hz is planned with power levels at or above 1 MW. Since the long pulse may give future opportunities for higher power, this study is looking at 3 MW to compare the performance of a solid rotating target to a mercury target. Unlike the case for stationary solid targets at such powers this study indicates that a rotating solid target, when used with large coupled hydrogen moderators, has neutronic performance equal to or better than that with a mercury target, and the solid target has a greatly increased lifetime. Design studies have investigated water cooled tungsten targets with tantalum cladding approximately 1.2 m in diameter, and 70mm thick. Operating temperatures are low ( < 150 C) with mid-plane, top and bottom surface cooling. In case of cooling system failure, the diameter gives enough surface area to remove the decay heat by radiation to the surrounding reflector assemblies while keeping the peak temperatures below approximately 700 C. This temperature should mitigate potential loss of coolant accidents and subsequent steam, tungsten interaction which has a threshold of approximately 800 C. Design layouts for the sealing systems and potential target station concepts have been developed.

  11. Keys to Access: Argonne-INCREASE partnership opens doors to collaboration |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Key Terms Key Terms Three Door Keys data-key-571156_960_720.png Key Terms Low Vision: non-correctable reduced vision Blindness: lack of visual perception Hearing Impairment: full or partial decrease in the ability to detect or understand sounds Physical Impairment: a physical condition that permanently prevents normal body movement or control Cognitive Disabilities: difficulty with one or more types of mental tasks Argonne National Laboratory

    The INCREASE workshop gave visitors one-on-one

  12. Analysis of key safety metrics of thorium utilization in LWRs

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ade, Brian J.; Bowman, Stephen M.; Worrall, Andrew; Powers, Jeffrey

    2016-04-08

    Here, thorium has great potential to stretch nuclear fuel reserves because of its natural abundance and because it is possible to breed the 232Th isotope into a fissile fuel (233U). Various scenarios exist for utilization of thorium in the nuclear fuel cycle, including use in different nuclear reactor types (e.g., light water, high-temperature gas-cooled, fast spectrum sodium, and molten salt reactors), along with use in advanced accelerator-driven systems and even in fission-fusion hybrid systems. The most likely near-term application of thorium in the United States is in currently operating light water reactors (LWRs). This use is primarily based on conceptsmore » that mix thorium with uranium (UO2 + ThO2) or that add fertile thorium (ThO2) fuel pins to typical LWR fuel assemblies. Utilization of mixed fuel assemblies (PuO2 + ThO2) is also possible. The addition of thorium to currently operating LWRs would result in a number of different phenomenological impacts to the nuclear fuel. Thorium and its irradiation products have different nuclear characteristics from those of uranium and its irradiation products. ThO2, alone or mixed with UO2 fuel, leads to different chemical and physical properties of the fuel. These key reactor safety–related issues have been studied at Oak Ridge National Laboratory and documented in “Safety and Regulatory Issues of the Thorium Fuel Cycle” (NUREG/CR-7176, U.S. Nuclear Regulatory Commission, 2014). Various reactor analyses were performed using the SCALE code system for comparison of key performance parameters of both ThO2 + UO2 and ThO2 + PuO2 against those of UO2 and typical UO2 + PuO2 mixed oxide fuels, including reactivity coefficients and power sharing between surrounding UO2 assemblies and the assembly of interest. The decay heat and radiological source terms for spent fuel after its discharge from the reactor are also presented. Based on this evaluation, potential impacts on safety requirements and identification of

  13. Center for Inverse Design: Modality 2 - Design of Materials with Targeted

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Functionality 2: Design of Materials with Targeted Functionality Modality 2 applies to cases where we have numerous-perhaps thousands-of materials, each with a single (usually ground-state) configuration, and the desired target property is complex, so it currently cannot be computed on the fly. In this case, we use "design principles"-derived quantities that can be calculated for each material and which suggest key materials parameters that need to be obtained to get the relevant

  14. THERMAL OSCILLATIONS IN LIQUID HELIUM TARGETS.

    SciTech Connect (OSTI)

    WANG,L.; JIA,L.X.

    2001-07-16

    A liquid helium target for the high-energy physics was built and installed in the proton beam line at the Alternate Gradient Synchrotron of Brookhaven National Laboratory in 2001. The target flask has a liquid volume of 8.25 liters and is made of thin Mylar film. A G-M/J-T cryocooler of five-watts at 4.2K was used to produce liquid helium and refrigerate the target. A thermosyphon circuit for the target was connected to the J-T circuit by a liquid/gas separator. Because of the large heat load to the target and its long transfer lines, thermal oscillations were observed during the system tests. To eliminate the oscillation, a series of tests and analyses were carried out. This paper describes the phenomena and provides the understanding of the thermal oscillations in the target system.

  15. Key Geomechanics Issues at the Waste Isolation Pilot Plant Geomechanics

    SciTech Connect (OSTI)

    HANSEN,FRANCIS D.

    1999-09-01

    Mechanical and hydrological properties of rock salt provide excellent bases for geological isolation of hazardous materials. Regulatory compliance determinations for the Waste Isolation Pilot Plant (WIPP) stand as testament to the widely held conclusion that salt provides excellent isolation properties. The WIPP saga began in the 1950s when the U.S. National Academy of Sciences (NAS) recommended a salt vault as a promising solution to the national problem of nuclear waste disposal. For over 20 years, the Scientific basis for the NAS recommendation has been fortified by Sandia National Laboratories through a series of large scale field tests and laboratory investigations of salt properties. These scientific investigations helped develop a comprehensive understanding of salt's 4 reformational behavior over an applicable range of stresses and temperatures. Sophisticated constitutive modeling, validated through underground testing, provides the computational ability to model long-term behavior of repository configurations. In concert with advancement of the mechanical models, fluid flow measurements showed not only that the evaporite lithology was essentially impermeable but that the WIPP setting was hydrologically inactive. Favorable mechanical properties ensure isolation of materials placed in a salt geological setting. Key areas of the geomechanics investigations leading to the certification of WIPP are in situ experiments, laboratory tests, and shaft seal design.

  16. Key issues of ultraviolet radiation of OH at high altitudes

    SciTech Connect (OSTI)

    Zhang, Yuhuai; Wan, Tian; Jiang, Jianzheng; Fan, Jing

    2014-12-09

    Ultraviolet (UV) emissions radiated by hydroxyl (OH) is one of the fundamental elements in the prediction of radiation signature of high-altitude and high-speed vehicle. In this work, the OH A{sup 2}?{sup +}?X{sup 2}? ultraviolet emission band behind the bow shock is computed under the experimental condition of the second bow-shock ultraviolet flight (BSUV-2). Four related key issues are discussed, namely, the source of hydrogen element in the high-altitude atmosphere, the formation mechanism of OH species, efficient computational algorithm of trace species in rarefied flows, and accurate calculation of OH emission spectra. Firstly, by analyzing the typical atmospheric model, the vertical distributions of the number densities of different species containing hydrogen element are given. According to the different dominating species containing hydrogen element, the atmosphere is divided into three zones, and the formation mechanism of OH species is analyzed in the different zones. The direct simulation Monte Carlo (DSMC) method and the Navier-Stokes equations are employed to compute the number densities of the different OH electronically and vibrationally excited states. Different to the previous work, the trace species separation (TSS) algorithm is applied twice in order to accurately calculate the densities of OH species and its excited states. Using a non-equilibrium radiation model, the OH ultraviolet emission spectra and intensity at different altitudes are computed, and good agreement is obtained with the flight measured data.

  17. Do myoepithelial cells hold the key for breast tumorprogression?

    SciTech Connect (OSTI)

    Polyak, Kornelia; Hu, Min

    2005-11-18

    Mammary myoepithelial cells have been the foster child of breast cancer biology and have been largely ignored since they were considered to be less important for tumorigenesis than luminal epithelial cells from which most of breast carcinomas are thought to arise. In recent years as our knowledge in stem cell biology and the cellular microenvironment has been increasing myoepithelial cells are slowly starting to gain more attention. Emerging data raise the hypothesis if myoepithelial cells play a key role in breast tumor progression by regulating the in situ to invasive carcinoma transition and if myoepithelial cells are part of the mammary stem cell niche. Paracrine interactions between myoepithelial and luminal epithelial cells are known to be important for cell cycle arrest, establishing epithelial cell polarity, and inhibiting migration and invasion. Based on these functions normal mammary myoepithelial cells have been called ''natural tumor suppressors''. However, during tumor progression myoepithelial cells seem to loose these properties and eventually they themselves diminish as tumors become invasive. Better understanding of myoepithelial cell function and their role in tumor progression may lead to their exploitation for cancer therapeutic and preventative measures.

  18. Ion acceleration enhanced by target ablation

    SciTech Connect (OSTI)

    Zhao, S.; Lin, C. Wang, H. Y.; Lu, H. Y.; He, X. T.; Yan, X. Q.; Chen, J. E.; Cowan, T. E.

    2015-07-15

    Laser proton acceleration can be enhanced by using target ablation, due to the energetic electrons generated in the ablation preplasma. When the ablation pulse matches main pulse, the enhancement gets optimized because the electrons' energy density is highest. A scaling law between the ablation pulse and main pulse is confirmed by the simulation, showing that for given CPA pulse and target, proton energy improvement can be achieved several times by adjusting the target ablation.

  19. COST OF ADDRESSING TARGETS OF UNEQUAL VALUE

    SciTech Connect (OSTI)

    G.H. CANAVAN

    2001-08-01

    The formalism for evaluating first strike costs and incentives for military targeting generalize to include higher value targets. That introduces two new allocations to the usual allocation between missiles and military targets, but they can be performed analytically. As the number of weapons on each side decreases, the optimal fraction of second strike weapons allocated to military values falls. The shift to high value targets is more pronounced below about 1,000 weapons for nominal parameters. Below 500 weapons the first striker's cost of action drops below its cost of inaction. A strike would induce a second strike of about 250 weapons on high value targets. An increase in the first striker's preference for damage to the other's high value targets increases or a decrease in its preference for preventing damage to its own high value targets decreases first strike costs and stability margins. Including defenses complicates allocations slightly. The main effect is increased attrition of second strikes, particularly at larger defenses, which makes it possible to significantly reduce damage to high value targets. At 1,000 weapons, by 300 to 400 interceptors the first striker's costs are reduced to 30% below that of inaction and the number of weapons delivered on the first striker's high value targets is reduced to about 100.

  20. Enterprise Assessments Targeted Review, Lawrence Livermore National...

    Broader source: Energy.gov (indexed) [DOE]

    Targeted Review of the Safety-Class Room Ventilation Systems and Associated Final Filtration Stages, and Review of Federal Assurance Capability at the Lawrence Livermore National...

  1. On Target December 2014 | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Back to the Top>>> The On Target newsletter is published by the Thomas Jefferson National Accelerator Facility (Jefferson Lab), a nuclear physics research laboratory in Newport ...

  2. Enterprise Assessments Lessons Learned From Targeted Reviews...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Work Planning and Control - March 2016 Enterprise Assessments Lessons Learned From Targeted Reviews of Activity-Level Work Planning and Control - March 2016 March 2016 ...

  3. Project Plan Remote Target Fabrication Refurbishment Project

    SciTech Connect (OSTI)

    Bell, Gary L; Taylor, Robin D

    2009-08-01

    In early FY2009, the DOE Office of Science - Nuclear Physics Program reinstated a program for continued production of {sup 252}Cf and other transcurium isotopes at the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). The FY2009 major elements of the workscope are as follows: (1) Recovery and processing of seven transuranium element targets undergoing irradiation at the High Flux Isotope Reactor (HFIR) at ORNL; (2) Development of a plan to manufacture new targets for irradiation beginning in early- to mid-FY10 to supply irradiated targets for processing Campaign 75 (TRU75); and (3) Refurbishment of the target manufacturing equipment to allow new target manufacture in early FY10 The {sup 252}Cf product from processing Campaign 74 (recently processed and currently shipping to customers) is expected to supply the domestic demands for a period of approximately two years. Therefore it is essential that new targets be introduced for irradiation by the second quarter of FY10 (HFIR cycle 427) to maintain supply of {sup 252}Cf; the average irradiation period is {approx}10 HFIR cycles, requiring about 1.5 calendar years. The strategy for continued production of {sup 252}Cf depends upon repairing and refurbishing the existing pellet and target fabrication equipment for one additional target production campaign. This equipment dates from the mid-1960s to the late 1980s, and during the last target fabrication campaign in 2005- 2006, a number of component failures and operations difficulties were encountered. It is expected that following the target fabrication and acceptance testing of the targets that will supply material for processing Campaign 75 a comprehensive upgrade and replacement of the remote hot-cell equipment will be required prior to subsequent campaigns. Such a major refit could start in early FY 2011 and would take about 2 years to complete. Scope and cost estimates for the repairs described herein were developed, and

  4. Magnetic confinement system using charged ammonia targets

    DOE Patents [OSTI]

    Porter, Gary D.; Bogdanoff, Anatoly

    1979-01-01

    A system for guiding charged laser targets to a predetermined focal spot of a laser along generally arbitrary, and especially horizontal, directions which comprises a series of electrostatic sensors which provide inputs to a computer for real time calculation of position, velocity, and direction of the target along an initial injection trajectory, and a set of electrostatic deflection means, energized according to a calculated output of said computer, to change the target trajectory to intercept the focal spot of the laser which is triggered so as to illuminate the target of the focal spot.

  5. Setting Energy Savings Targets for Utilities

    SciTech Connect (OSTI)

    none,

    2011-09-01

    Helps policymakers understand how electric and natural gas utilities can achieve greater efficiency by establishing numeric energy savings targets and goals for energy efficiency programs.

  6. Enterprise Assessments Lessons Learned from Targeted Reviews...

    Broader source: Energy.gov (indexed) [DOE]

    Lessons Learned from Targeted Reviews of Fire Protection Programs at Department of Energy Nuclear Facilities August 2015 Office of Nuclear Safety and Environmental Assessments...

  7. NERSC HPC Requirements Reviews: Target 2017

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Basic Energy Sciences (BES) Biological and Environmental Research (BER) Fusion Energy Sciences (FES) High Energy Physics (HEP) Nuclear Physics (NP) Requirements Reviews: Target ...

  8. Lithium thermal targets shot on PBFA II

    SciTech Connect (OSTI)

    Sawyer, P.S.; Aubert, J.H.; Baca, P.M.; McNamara, W.F.

    1993-09-01

    Recent lithium ion beam experiments on PBFAII have required intricate targets to measure beam performance and to study target physics issues. Because of the stopping power difference between lithium ions and protons, these targets have presented significantly increased challenges for material preparation and handling compared to previous proton shots. The greatest challenges included complex shaped gold hohlraums, CH foams of densities ranging from 3 to 6 mg/cm3 and vacuum seals covering large areas with a thickness under 1 um. Details regarding assembly and characterization of lithium thermal targets will be described in this poster.

  9. Enterprise Assessments, Lessons Learned from Targeted Reviews...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Enterprise Assessments (EA), Office of Environment, Safety and Health Assessments, ... hazard analysis and implementation of work controls) as a targeted assessment area ...

  10. Enterprise Assessments Lessons Learned from Targeted Reviews...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    organizational learning. Enterprise Assessments Lessons Learned from Targeted Reviews of the Management of Safety ... Office - March 2012 Safety System Oversight Assessment, Los ...

  11. NIF Target Chamber Dedicated | National Nuclear Security Administration |

    National Nuclear Security Administration (NNSA)

    (NNSA) NIF Target Chamber Dedicated NIF Target Chamber Dedicated Livermore, CA Secretary Richardson dedicates the National Ignition Facility target chamber at DOE's Lawrence Livermore National Laboratory

  12. Maquoketa paleotopography key to reservoirs in western Illinois

    SciTech Connect (OSTI)

    Whitaker, S.T.; Ledbetter, J.C.

    1996-08-12

    Shallow Silurian reservoirs in western Illinois have been a primary target for exploration since the late 1950s. It was not until the discovery and development of Buckhorn Consolidated field in the early 1980s, however, that significant drilling efforts for Silurian reservoirs were focused on western Illinois. At Buckhorn, 1.7 million bbl of oil have been produced from a basal Silurian dolomite at about 650 ft. Drawn by inexpensive drilling and available acreage, hundreds of operators flocked to western Illinois to try their luck. By the late 1980s, however, exploration efforts in western Illinois were curtailed due to the failure to locate additional significant reservoirs. Much of this failure was due to the lack of a suitable geologic model that could be used to explain the reason for reservoir development and thereby guide exploration efforts. An article by Whitaker and Howard in 1995 presented a geologic model explaining Silurian reservoir development and stratigraphic entrapment of oil at Buckhorn Consolidated field were formed as Silurian dolomite in-filled a shallow paleovalley cut into the underlying Ordovician Maquoketa shale. Some companies have recently initiated new exploration efforts in the area using this model. This paper discusses the efforts and results of several of these new areas.

  13. EIA cites importance of key world shipping routes

    SciTech Connect (OSTI)

    Not Available

    1994-03-07

    A disruption of crude oil or products shipments through any of six world chokepoints would cause a spike in oil prices, the US Energy Information Administration (EIA) warns. The strategic importance of each major shipping lane varies because of differing oil volumes and access to other transportation routes. But nearly half of the 66 million b/d of oil consumed worldwide flows through one or more of these key tanker routes, involving: 14 million b/d through the Strait of Hormuz from the Persian Gulf to the Gulf of Oman and Arabian Sea; 7 million b/d through the Strait of Malacca from the northern Indian Ocean into the South China Sea and Pacific Ocean; 1.6 million b/d through the Bosporus from the Black Sea to the Mediterranean Sea; 900,000 b/d through the Suez Canal from the Red Sea to the Mediterranean Sea; 600,000 b/d through Rotterdam Harbor from the North Sea to Dutch and German refineries on or near the Rhine River; and 500,000 b/d through the Panama Canal from the Pacific Ocean to the Caribbean Sea. In today's highly interdependent oil markets, the mere perception of less secure oil supplies is enough to boost oil prices, EIA said. Growing oil and product tanker traffic is increasing the likelihood of supply disruptions through oil arteries because of bad weather, tanker collisions, or acts of piracy, terrorism, or war. What's more, the increasing age of the world tanker fleet and dependability of navigational equipment could increase chances of accidents and, therefore, oil supply disruptions.

  14. Wireless power transmission: The key to solar power satellites

    SciTech Connect (OSTI)

    Nansen, R.H.

    1995-12-31

    In the years following the OPEC oil embargo of 1973--74, the US aggressively researched alternative energy options. Among those studied was the concept of Solar Power Satellites -- generating electricity in space from solar energy on giant satellites and sending the energy to the earth with wireless power transmission. Much has happened in the fifteen years since the studies were terminated. Maturing of the enabling technologies has provided much of the infrastructure to support the development of a commercial Solar Power Satellite program. All of this will reduce the cost by one to two orders of magnitude so development can now be undertaken by industry instead of relying on a massive government program. Solar Space Industries was formed to accomplish this goal. The basis of their development plan for Solar Power Satellites is to build a Ground Test Installation that will duplicate, in small scale on the earth, all aspects of the power generating and power transmission systems for the Solar Power Satellite concept except for the space environment and the range and size of the energy beam. Space operations issues will be separated from the power generation function and verified by testing using the NASA Space Station and Space Shuttle. Solar Space Industries` concept is to built a Ground Test Installation that couples an existing 100 kW terrestrial solar cell array, furnished by an interested utility, to a phased-array wireless power transmitter based on the subarray developed by William Brown and The Center for Space Power. Power will be transmitted over a 1 1/4 mile range to a receiving antenna (rectenna) and then fed into a commercial utility power grid. The objective is to demonstrate the complete function of the Solar Power Satellites, with the primary issue being the validation of practical wireless power transmission. The key features to demonstrate are; beam control, stability, steering, efficiency, reliability, cost, and safety.

  15. SOURCE TERM TARGETED THRUST FY 2005 NEW START PROJECTS

    SciTech Connect (OSTI)

    NA

    2005-10-05

    While a significant amount of work has been devoted to developing thermodynamic data. describing the sorption of radionuclides to iron oxides and other geomedia, little data exist to describe the interaction of key radionuclides found in high-level radioactive waste with the uranium surfaces expected in corroded spent nuclear fuel (SNF) waste packages. Recent work indicates that actinide adsorption to the U(VI) solids expected in the engineered barrier system may play a key role in the reduction of dissolved concentrations of radionuclides such as Np(V). However, little is known about the mechanism(s) of adsorption, nor are the thermodynamic data available to represent the phenomenon in predictive modeling codes. Unfortunately, this situation makes it difficult to consider actinide adsorption to the U(VI) silicates in either geochemical or performance assessment (PA) predictions. The primary goal in the Source Term Targeted Thrust area is to ''study processes that control radionuclide release from the waste form''. Knowledge of adsorption of actinides to U(VI) silicate solids its and parameterization in geochemical models will be an important step towards this goal.

  16. Technical Design Report, Second Target Station

    SciTech Connect (OSTI)

    Galambos, John D.; Anderson, David E.; Bechtol, D.; Bethea, Katie L.; Brown, N.; Carden, W. F.; Chae, Steven M.; Clark, A.; Counce, Deborah M.; Craft, K.; Crofford, Mark T.; Collins, Richard M.; Cousineau, Sarah M.; Curry, Douglas E.; Cutler, Roy I.; Dayton, Michael J.; Dean, Robert A.; Deibele, Craig E.; Doleans, Marc; Dye, T.; Eason, Bob H.; Eckroth, James A.; Fincrock, C.; Fritts, S.; Gallmeier, Franz X.; Gawne, Ken R.; Hartman, Steven M.; Herwig, Kenneth W.; Hess, S.; Holmes, Jeffrey A.; Horak, Charlie M.; Howell, Matthew P.; Iverson, Erik B.; Jacobs, Lorelei L.; Jones, Larry C.; Johnson, B.; Johnson, S.; Kasemir, Kay; Kim, Sang-Ho; Laughon, Gregory J.; Lu, W.; Mahoney, Kelly L.; Mammosser, John; McManamy, T.; Michilini, M.; Middendorf, Mark E.; O'Neal, Ed; Nemec, B.; Peters, Roy Cecil; Plum, Michael A.; Reagan, G.; Remec, Igor; Rennich, Mark J.; Riemer, Bernie; Saethre, Robert B.; Schubert, James Phillip; Shishlo, Andrei P.; Smith, C. Craig; Strong, William Herb; Tallant, Kathie M.; Tennant, David Alan; Thibadeau, Barbara M.; Trumble, S.; Trotter, Steven M.; Wang, Z.; Webb, Steven B.; Williams, Derrick C.; White, Karen S.; Zhao, Jinkui

    2015-01-01

    The Second Target Station (STS) is a proposed upgrade for SNS. It includes a doubling of the accelerator power and an additional instrument hall. The new instrument hall will receive a 467 kW 10 Hz beam. The parameters and preliminary design aspects of the STS are presented for the accelerator, target systems, instrument hall, instruments and civil construction aspects.

  17. ACCELERATOR TARGET POSITIONER AND CONTROL CIRCUIT THEREFOR

    DOE Patents [OSTI]

    Stone, K.F.; Force, R.J.; Olson, W.W.; Cagle, D.S.

    1959-12-15

    An apparatus is described for inserting and retracting a target material with respect to the internal beam of a charged particle accelerator and to circuitry for controlling the timing and motion of the target placement. Two drive coils are mounted on the shaft of a target holder arm and disposed within the accelerator magnetic field with one coil at right angles to the other. Control circuitry alternately connects each coil to a current source and to a varying shorting resistance whereby the coils interchangeably produce driving and braking forces which swing the target arm within a ninety degree arc. The target is thus moved into the beam and away from it at high speeds and is brought to rest after each movement without whiplash or vibration.

  18. The Jefferson Lab Frozen Spin Target

    SciTech Connect (OSTI)

    Christopher Keith, James Brock, Christopher Carlin, Sara Comer, David Kashy, Josephine McAndrew, David Meekins, Eugene Pasyuk, Joshua Pierce, Mikell Seely

    2012-08-01

    A frozen spin polarized target, constructed at Jefferson Lab for use inside a large acceptance spectrometer, is described. The target has been utilized for photoproduction measurements with polarized tagged photons of both longitudinal and circular polarization. Protons in TEMPO-doped butanol were dynamically polarized to approximately 90% outside the spectrometer at 5 T and 200-300 mK. Photoproduction data were acquired with the target inside the spectrometer at a frozen-spin temperature of approximately 30 mK with the polarization maintained by a thin, superconducting coil installed inside the target cryostat. A 0.56 T solenoid was used for longitudinal target polarization and a 0.50 T dipole for transverse polarization. Spin relaxation times as high as 4000 hours were observed. We also report polarization results for deuterated propanediol doped with the trityl radical OX063.

  19. Multishell inertial-confinement-fusion target

    SciTech Connect (OSTI)

    Holland, J.R.; Del Vecchio, R.M.

    1981-06-01

    This disclosure relates to fusion targets. It deals particularly with the production of multishell inertial confinement fusion targets. The fuel pellet within such targets is designed to compress isentropically under laser or particle irradiation. When a short pulse at extremely high power density strikes the target containing deuterium-tritium fuel, the resulting plasma is confined briefly by its own inertia. Thermonuclear energy can be released in less time than it takes the fuel pellet to blow apart. However, efficient thermonuclear burn requires that the plasma must remain intact at extremely high temperatures and densities for a time sufficient to allow a large fraction of the nuclei to react. Development of multishell targets has been directed at this problem.

  20. Lowest Engine-Out Emissions as the Key to the Future of the Heavy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Lowest Engine-Out Emissions as the Key to the Future of the Heavy-Duty Diesel Engine: New Development Rersults Lowest Engine-Out Emissions as the Key to the Future of the ...

  1. Structures of Clamp-Loader Complexes Are Key to DNA Replication

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structures of Clamp-Loader Complexes Are Key to DNA Replication Structures of Clamp-Loader Complexes Are Key to DNA Replication Print Wednesday, 30 May 2012 00:00 DNA Replication:...

  2. Explanations of FreedomCAR/DOE Hydrogen Storage Technical Targets

    Broader source: Energy.gov [DOE]

    Summary of FreedomCAR Targets and Basis for Targets prepared for the Grand Challenge Hydrogen Storage Solicitation.

  3. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print Tuesday, 23 June 2015 13:00 The cancer drug...

  4. Micro-fabrication Techniques for Target Components

    SciTech Connect (OSTI)

    Miles, R; Hamilton, J; Crawford, J; Ratti, S; Trevino, J; Graff, T; Stockton, C; Harvey, C

    2008-06-10

    Micro-fabrication techniques, derived from the semi-conductor industry, can be used to make a variety of useful mechanical components for targets. A selection of these components including supporting cooling arms for prototype cryogenic inertial confinement fusion targets, stepped and graded density targets for materials dynamics experiments are described. Micro-fabrication enables cost-effective, simultaneous fabrication of multiple high-precision components with complex geometries. Micro-fabrication techniques such as thin-film deposition, photo-lithographic patterning and etch processes normally used in the semi-conductor manufacture industry, can be exploited to make useful mechanical target components. Micro-fabrication processes have in recent years been used to create a number of micro-electro-mechanical systems (MEMS) components such as pressure sensors, accelerometers, ink jet printer heads, microfluidics platforms and the like. These techniques consist primarily of deposition of thin films of material, photo-lithographic patterning and etching processes performed sequentially to produce three dimensional structures using essentially planar processes. While the planar technology can be limiting in terms of the possible geometries of the final product, advantages of using these techniques include the ability to make multiple complex structures simultaneously and cost-effectively. Target components fabricated using these techniques include the supporting cooling arms for cryogenic prototype fusion ignition targets, stepped targets for equation-of-state experiments, and graded density reservoirs for material strength experiments.

  5. X-ray Digital Radiography and Computed Tomography of ICF and HEDP Materials, Subassemblies and Targets

    SciTech Connect (OSTI)

    Brown, W D; Martz Jr., H E

    2006-05-31

    Inertial confinement fusion (ICF) and high energy density physics (HEDP) research are being conducted at large laser facilities, such as the University of Rochester's Laboratory for Laser Energetics OMEGA facility and the Lawrence Livermore National Laboratory's (LLNL) National Ignition Facility (NIF). At such facilities, millimeter-sized targets with micrometer structures are studied in a variety of hydrodynamic, radiation transport, equation-of-state, inertial confinement fusion and high-energy density experiments. The extreme temperatures and pressures achieved in these experiments make the results susceptible to imperfections in the fabricated targets. Targets include materials varying widely in composition ({approx}3 < Z < {approx}82), density ({approx}0.03 to {approx}20 g/cm{sup 3}), geometry (planar to spherical) and embedded structures (joints to subassemblies). Fabricating these targets with structures to the tolerances required is a challenging engineering problem the ICF and HEDP community are currently undertaking. Nondestructive characterization (NDC) provides a valuable tool in material selection, component inspection, and the final pre-shot assemblies inspection. X-rays are a key method used to NDC these targets. In this paper we discuss X-ray attenuation, X-ray phase effects, and the X-ray system used, its performance and application to characterize low-temperature Raleigh-Taylor and non-cryogenic double-shell targets.

  6. Self-assessing target with automatic feedback

    DOE Patents [OSTI]

    Larkin, Stephen W.; Kramer, Robert L.

    2004-03-02

    A self assessing target with four quadrants and a method of use thereof. Each quadrant containing possible causes for why shots are going into that particular quadrant rather than the center mass of the target. Each possible cause is followed by a solution intended to help the marksman correct the problem causing the marksman to shoot in that particular area. In addition, the self assessing target contains possible causes for general shooting errors and solutions to the causes of the general shooting error. The automatic feedback with instant suggestions and corrections enables the shooter to improve their marksmanship.

  7. Non-PGM Catalyst Targets: Summary

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Arlington, Virginia Crystal Gateway Marriott Hotel - Monday, June 8, 2015 Non-PGM Catalyst Performance Targets - Summary Catalysis Working Group, Arlington, VA - June 8 th , 2015 4 Discussion of Non-PGM ORR Catalyst Targets * Non-PGM ORR catalyst targets and test protocols discussed extensively at four CWG meetings: - Arlington, VA on May 15 th , 2013 (open CWG meeting at AMR) - Golden, CO on December 18 th , 2013 (joint CWG-DWG meeting; contractors only) - Washington, D.C. on June 16 th , 2014

  8. Table IV: Technical Targets for Membranes: Stationary

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    IV: Technical Targets for Membranes: Stationary All targets must be achieved simultaneously Characteristics Units Calendar year 2002 status a 2005 2010 Membrane conductivity, operating temperature Ω-cm 2 0.1 0.1 0.1 Oxygen cross-over b mA/cm 2 5 5 2 Hydrogen cross-over b mA/cm 2 5 5 2 Cost $/kW 50 5 Operating Temperature o C 160 160 170 Durability Hours 5000 >15000 >40000 Survivability o C -20 -30 -40 Notes: a) Status is present day 80 o C unless otherwise noted; targets are for new

  9. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein...

  10. FACT SHEET ON THE CONSEQUENCES OF A FAILED DRUG TEST

    Office of Environmental Management (EM)

    SHEET ON THE CONSEQUENCES OF A POSITIVE DRUG TEST The Secretary has determined that ... The information below summarizes the consequences of a positive test for drugs for each ...

  11. Spontaneous Liver Rupture After Treatment With Drug-Eluting Beads...

    Office of Scientific and Technical Information (OSTI)

    Country of Publication: United States Language: English Subject: 62 RADIOLOGY AND NUCLEAR ... DRUGS; BODY; CARCINOMAS; DIGESTIVE SYSTEM; DISEASES; DRUGS; FAILURES; GLANDS; ...

  12. Flow cytometry aids basic cell biology research and drug discovery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Life Technologies Corporation and LANL have ...

  13. Food and Drug Administration White Oak Campus Environmental Stewardshi...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Food and Drug Administration White Oak Campus Environmental Stewardship and Cost Savings FEMP ESPC Success Story on water conservation and green energy at the Food and Drug ...

  14. The generation of shared cryptographic keys through channel impulse response estimation at 60 GHz.

    SciTech Connect (OSTI)

    Young, Derek P.; Forman, Michael A.; Dowdle, Donald Ryan

    2010-09-01

    Methods to generate private keys based on wireless channel characteristics have been proposed as an alternative to standard key-management schemes. In this work, we discuss past work in the field and offer a generalized scheme for the generation of private keys using uncorrelated channels in multiple domains. Proposed cognitive enhancements measure channel characteristics, to dynamically change transmission and reception parameters as well as estimate private key randomness and expiration times. Finally, results are presented on the implementation of a system for the generation of private keys for cryptographic communications using channel impulse-response estimation at 60 GHz. The testbed is composed of commercial millimeter-wave VubIQ transceivers, laboratory equipment, and software implemented in MATLAB. Novel cognitive enhancements are demonstrated, using channel estimation to dynamically change system parameters and estimate cryptographic key strength. We show for a complex channel that secret key generation can be accomplished on the order of 100 kb/s.

  15. Secure Cryptographic Key Management System (CKMS) Considerations for Smart Grid Devices

    SciTech Connect (OSTI)

    Abercrombie, Robert K; Sheldon, Frederick T; Aldridge, Hal; Duren, Mike; Ricci, Tracy; Bertino, Elisa; Kulatunga, Athula; Navaratne, Uditha Sudheera

    2011-01-01

    In this paper, we examine some unique challenges associated with key management in the Smart Grid and concomitant research initiatives: 1) effectively model security requirements and their implementations, and 2) manage keys and key distribution for very large scale deployments such as Smart Meters over a long period of performance. This will set the stage to: 3) develop innovative, low cost methods to protect keying material, and 4) provide high assurance authentication services. We will present our perspective on key management and will discuss some key issues within the life cycle of a cryptographic key designed to achieve the following: 1) control systems designed, installed, operated, and maintained to survive an intentional cyber assault with no loss of critical function, and 2) widespread implementation of methods for secure communication between remote access devices and control centers that are scalable and cost-effective to deploy.

  16. Webinar: Targeted Algal Biofuels and Bioproducts FOA

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Energy Department’s Bioenergy Technologies Office will present a live informational webcast on the Targeted Algal Biomass and Bioproducts Funding Opportunity (DE-FOA-0001162) on October 8, 2014...

  17. FUEL & TARGET FABRICATION Aiken County, South Carolina

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    M Area is the site of Savannah River Plant's fuel and target fabrication facilities operated from 1955 through the end of the Cold War, producing fuel elements to be irradiated in ...

  18. Enhancing proton acceleration by using composite targets

    SciTech Connect (OSTI)

    Bulanov, S. S.; Esarey, E.; Schroeder, C. B.; Bulanov, S. V.; Esirkepov, T. Zh.; Kando, M.; Pegoraro, F.; Leemans, W. P.

    2015-07-10

    Efficient laser ion acceleration requires high laser intensities, which can only be obtained by tightly focusing laser radiation. In the radiation pressure acceleration regime, where the tightly focused laser driver leads to the appearance of the fundamental limit for the maximum attainable ion energy, this limit corresponds to the laser pulse group velocity as well as to another limit connected with the transverse expansion of the accelerated foil and consequent onset of the foil transparency. These limits can be relaxed by using composite targets, consisting of a thin foil followed by a near critical density slab. Such targets provide guiding of a laser pulse inside a self-generated channel and background electrons, being snowplowed by the pulse, compensate for the transverse expansion. The use of composite targets results in a significant increase in maximum ion energy, compared to a single foil target case.

  19. OMEGA Targets - Laboratory for Laser Energetics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Targets - Laboratory for Laser Energetics Laboratory for Laser Energetics Logo Search Home Around the Lab Past Issues Past Quick Shots About Office of the Director Map to LLE LLE ...

  20. Inertial fusion target fabrication using polystyrene mandrels

    SciTech Connect (OSTI)

    Kim, H.; Powers, T.F.; Mason, J.F.

    1984-04-01

    Large-aspect-ratio, plastic-coated, metal shells are useful targets for obtaining valuable information on thermal transport in laser implosion experiments. We have found that by using polystyrene as a leachable mandrel, it is possible to fabricate such complex, inertial-fusion targets. The present fabrication technique offers advantages over previous techniques, including the hemispherical-shell approach, the leachable-metal-mandrel approach, and the coating of a prefabricated metal shell. For fabrication of such diagnostic targets, comprised of a high-aspect-ratio, plastic-coated, metal shell, a polystyrene sphere is mounted on a stalk, then coated with metal and parylene layers. A hole of 5--10 ..mu..m is drilled with a laser pulse through the layers and the polystyrene is then leached out by immersing the system in toluene. The concept of the present technique presents a number of possibilities for the fabrication of complex targets not possible previously.

  1. Cryostat including heater to heat a target

    DOE Patents [OSTI]

    Pehl, Richard H.; Madden, Norman W.; Malone, Donald F.

    1990-01-01

    A cryostat is provided which comprises a vacuum vessel; a target disposed within the vacuum vessel; a heat sink disposed within the vacuum vesssel for absorbing heat from the detector; a cooling mechanism for cooling the heat sink; a cryoabsorption mechanism for cryoabsorbing residual gas within the vacuum vessel; and a heater for maintaining the target above a temperature at which the residual gas is cryoabsorbed in the course of cryoabsorption of the residual gas by the cryoabsorption mechanism.

  2. Cryostat including heater to heat a target

    DOE Patents [OSTI]

    Pehl, R.H.; Madden, N.W.; Malone, D.F.

    1990-09-11

    A cryostat is provided which comprises a vacuum vessel; a target disposed within the vacuum vessel; a heat sink disposed within the vacuum vessel for absorbing heat from the detector; a cooling mechanism for cooling the heat sink; a cryoabsorption mechanism for cryoabsorbing residual gas within the vacuum vessel; and a heater for maintaining the target above a temperature at which the residual gas is cryoabsorbed in the course of cryoabsorption of the residual gas by the cryoabsorption mechanism. 2 figs.

  3. Enterprise Assessments Targeted Review, Sandia National Laboratories -

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    November 2014 | Department of Energy Sandia National Laboratories - November 2014 Enterprise Assessments Targeted Review, Sandia National Laboratories - November 2014 November 2014 Targeted Review of Work Planning and Control at the Sandia National Laboratories The U.S. Department of Energy (DOE) Office of Environment, Safety and Health Assessments, within the Office of Enterprise Assessments, conducted an independent review of the Sandia National Laboratories (SNL) activity-level work

  4. Method and apparatus for producing cryogenic targets

    SciTech Connect (OSTI)

    Murphy, J.T.; Miller, J.R.

    1981-08-28

    An improved method and apparatus are given for producing cryogenic inertially driven fusion targets in the fast isothermal freezing (FIF) method. Improved coupling efficiency and greater availability of volume near the target for diagnostic purposes and for fusion driver beam propagation result. Other embodiments include a new electrical switch and a new explosive detonator, all embodiments making use of a purposeful heating by means of optical fibers.

  5. Design of the Target Fabrication Tritium Laboratory

    SciTech Connect (OSTI)

    Sherohman, J.W.; Roberts, D.H.; Levine, B.H.

    1982-05-05

    The design of the Target Fabrication Tritium Laboratory for deuterium-tritium fuel processing for laser fusion targets has been accomplished with the intent of providing redundant safeguard systems. The design of the tritium laboratory is based on a combination of tritium handling techniques that are currently used by experienced laboratories. A description of the laboratory in terms of its interrelated processing systems is presented to provide an understanding of the design features for safe operation.

  6. Temperature and RH Targets | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Temperature and RH Targets Temperature and RH Targets Presented by Vishal O Mittal of the Florida Solar Energy Center at the High Temperature Membrane Working Group Meeting, San Francisco, September 14, 2006. htmwg_mittal.pdf (158.62 KB) More Documents & Publications High Temperature Membrane with HUmidification-Independent Cluster Structure Lead Research and Development Activity for High Temperature, Low Relative Humidity Membrane Program High Temperature Membrane Working Group, Minutes of

  7. Method and apparatus for producing cryogenic targets

    DOE Patents [OSTI]

    Murphy, J.T.; Miller, J.R.

    1984-08-07

    An improved method and apparatus are given for producing cryogenic inertially driven fusion targets in the fast isothermal freezing (FIF) method. Improved coupling efficiency and greater availability of volume near the target for diagnostic purposes and for fusion driver beam propagation result. Other embodiments include a new electrical switch and a new explosive detonator, all embodiments making use of a purposeful heating by means of optical fibers. 6 figs.

  8. Method and apparatus for producing cryogenic targets

    DOE Patents [OSTI]

    Murphy, James T.; Miller, John R.

    1984-01-01

    An improved method and apparatus are given for producing cryogenic inertially driven fusion targets in the fast isothermal freezing (FIF) method. Improved coupling efficiency and greater availability of volume near the target for diagnostic purposes and for fusion driver beam propagation result. Other embodiments include a new electrical switch and a new explosive detonator, all embodiments making use of a purposeful heating by means of optical fibers.

  9. DOE Program/Targets and Workshop Objectives

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Nancy Garland DOE Hydrogen Program Fuel Cell Operation at Sub- Freezing Temperatures DOE Program/Targets and Workshop Objectives Sub-Freezing Temperature Effects on Fuel Cells Workshop Phoenix AZ February 1-2, 2005 Hydrogen Fuel Initiative The Hydrogen, Fuel Cells, and Infrastructure Technologies Program Technical Targets DOE Fuel Cell & Hydrogen Activities Workshop Objectives Outline Hydrogen Fuel Initiative Presidential Initiative commits $1.7 Billion over 5 years - $1.2 Billion for

  10. Independent Oversight Targeted Review, Sandia National Laboratories -

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    April 2014 | Department of Energy April 2014 Independent Oversight Targeted Review, Sandia National Laboratories - April 2014 April 2014 Targeted Review of the Sandia National Laboratories Federal Assurance Capability The U.S. Department of Energy (DOE) Office of Enforcement and Oversight, within the Office of Health, Safety and Security (HSS), conducted an independent review of the performance of the DOE Sandia Field Office safety oversight of the Sandia Corporation. The review was

  11. NDCX-II target experiments and simulations

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Barnard, J. J.; More, R. M.; Terry, M.; Friedman, A.; Henestroza, E.; Koniges, A.; Kwan, J. W.; Ng, A.; Ni, P. A.; Liu, W.; et al

    2013-06-13

    The ion accelerator NDCX-II is undergoing commissioning at Lawrence Berkeley National Laboratory (LBNL). Its principal mission is to explore ion-driven High Energy Density Physics (HEDP) relevant to Inertial Fusion Energy (IFE) especially in the Warm Dense Matter (WDM) regime. We have carried out hydrodynamic simulations of beam-heated targets for parameters expected for the initial configuration of NDCX-II. For metal foils of order one micron thick (thin targets), the beam is predicted to heat the target in a timescale comparable to the hydrodynamic expansion time for experiments that infer material properties from measurements of the resulting rarefaction wave. We have alsomore » carried out hydrodynamic simulations of beam heating of metallic foam targets several tens of microns thick (thick targets) in which the ion range is shorter than the areal density of the material. In this case shock waves will form and we derive simple scaling laws for the efficiency of conversion of ion energy into kinetic energy of fluid flow. Geometries with a tamping layer may also be used to study the merging of a tamper shock with the end-of-range shock. As a result, this process can occur in tamped, direct drive IFE targets.« less

  12. Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile

    SciTech Connect (OSTI)

    Koenig, Xaver; Kovar, Michael; Rubi, Lena; Mike, Agnes K.; Lukacs, Peter; Gawali, Vaibhavkumar S.; Todt, Hannes; Hilber, Karlheinz; Sandtner, Walter

    2013-12-01

    The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licenced as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Na{sub v}1.5 sodium and Ca{sub v}1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (? 10 ?M) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. - Highlights: We study effects of anti-addiction drug ibogaine on ionic currents in cardiomyocytes. We assess the cardiac ion channel profile of ibogaine. Ibogaine inhibits hERG potassium, sodium and calcium channels. Ibogaines effects on ion channels are a potential

  13. Table IV: Technical Targets for Membranes: Stationary | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy IV: Technical Targets for Membranes: Stationary Table IV: Technical Targets for Membranes: Stationary "Technical targets for fuel cell membranes in stationary applications defined by the High Temperature Working Group (February 2003). " technical_targets_membr_stat.pdf (83.24 KB) More Documents & Publications Table II: Technical Targets for Membranes: Automotive Table III: Technical Targets for Catalyst Coated Membranes (CCMs): Stationary Table I: Technical Targets for

  14. Fast ignition of inertial confinement fusion targets

    SciTech Connect (OSTI)

    Gus'kov, S. Yu.

    2013-01-15

    Results of studies on fast ignition of inertial confinement fusion (ICF) targets are reviewed. The aspects of the fast ignition concept, which consists in the separation of the processes of target ignition and compression due to the synchronized action of different energy drivers, are considered. Criteria for the compression ratio and heating rate of a fast ignition target, the energy balance, and the thermonuclear gain are discussed. The results of experimental and theoretical studies of the heating of a compressed target by various types of igniting drivers, namely, beams of fast electrons and light ions produced under the action of a petawatt laser pulse on the target, a heavy-ion beam generated in the accelerator, an X-ray pulse, and a hydrodynamic flow of laser-accelerated matter, are analyzed. Requirements to the igniting-driver parameters that depend on the fast ignition criteria under the conditions of specific target heating mechanisms, as well as possibilities of practical implementation of these requirements, are discussed. The experimental programs of various laboratories and the prospects of practical implementation of fast ignition of ICF targets are reviewed. To date, fast ignition is the most promising method for decreasing the ignition energy and increasing the thermonuclear gain of an ICF plasma. A large number of publications have been devoted to investigations of this method and adjacent problems of the physics of igniting drivers and their interaction with plasma. This review presents results of only some of these studies that, in the author's opinion, allow one to discuss in detail the main physical aspects of the fast ignition concept and understand the current state and prospects of studies in this direction.

  15. In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27

    SciTech Connect (OSTI)

    Acosta-Reyes, Francisco J.; Dardonville, Christophe; Koning, Harry P. de; Natto, Manal; Subirana, Juan A.; Campos, J. Lourdes

    2014-06-01

    New features of an antiprotozoal DNA minor-groove binding drug, which acts as a cross-linking agent, are presented. It also fills the minor groove of DNA completely and prevents the access of proteins. These features are also expected for other minor-groove binding drugs when associated with suitable DNA targets. The DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies of drugs which interact with the minor groove of DNA, some of which are used in medical practice. Previous studies have been performed almost exclusively with the AATT sequence. New features should be uncovered through the study of different DNA sequences. In this paper, the crystal structure of the complex of the DNA duplex d(AAAATTTT){sub 2} with the dicationic drug 4, 4?-bis(imidazolinylamino)diphenylamine (CD27) is presented. The drug binds to the minor groove of DNA as expected, but it shows two new features that have not previously been described: (i) the drugs protrude from the DNA and interact with neighbouring molecules, so that they may act as cross-linking agents, and (ii) the drugs completely cover the whole minor groove of DNA and displace bound water. Thus, they may prevent the access to DNA of proteins such as AT-hook proteins. These features are also expected for other minor-groove binding drugs when associated with all-AT DNA. These findings allow a better understanding of this family of compounds and will help in the development of new, more effective drugs. New data on the biological interaction of CD27 with the causative agent of trichomoniasis, Trichomonas vaginalis, are also reported.

  16. Creation of mixed beam from alloy target and couple of pure targets with laser

    SciTech Connect (OSTI)

    Ikeda, Shunsuke Sekine, Megumi; Riken, Wako, Saitama ; Romanelli, Mark; Cinquegrani, David; Kumaki, Masafumi; Fuwa, Yasuhiro; Munemoto, Naoya; Horioka, Kazuhiko; Kanesue, Takeshi; Okamura, Masahiro; Jin, Qianyu

    2014-02-15

    To create mixed species ion beam with laser pulses, we investigated charge state distributions of plasma formed from both Al-Fe alloy targets and pure Al and Fe targets placed close together. With two targets, we observed that the two kinds of atoms were mixed when the interval of two laser pulses was large enough (40 μs). On the other hand, when the interval was 0.0 μs, we observed fewer Fe ions and they did not mix well with the Al ions. The two species were mixed well in the plasma from the alloy target. Furthermore, we observed that specific charge states of Fe ions increased. From the results, it was determined that we can use two pure targets to mix two species whose difference of the drift velocity is large. On the other hand, we must use an alloy target when the drift velocities of the species are close.

  17. Enterprise Assessments Targeted Review of the Targeted Review of the Safety

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Significant Ventilation System and Interconnected Portions of the Associated Safety Class Confinement System, and Review of Federal Assurance Capability at LANL TA-55 | Department of Energy Targeted Review of the Safety Significant Ventilation System and Interconnected Portions of the Associated Safety Class Confinement System, and Review of Federal Assurance Capability at LANL TA-55 Enterprise Assessments Targeted Review of the Targeted Review of the Safety Significant Ventilation System

  18. Secretary Bodman's Memorandum Regarding Drug Testing at DOE

    Broader source: Energy.gov [DOE]

    Decisions regarding drug testing for Department of Energy positions that require access authorizations (Security Clearances)

  19. Secure multi-party communication with quantum key distribution managed by trusted authority

    DOE Patents [OSTI]

    Nordholt, Jane Elizabeth; Hughes, Richard John; Peterson, Charles Glen

    2013-07-09

    Techniques and tools for implementing protocols for secure multi-party communication after quantum key distribution ("QKD") are described herein. In example implementations, a trusted authority facilitates secure communication between multiple user devices. The trusted authority distributes different quantum keys by QKD under trust relationships with different users. The trusted authority determines combination keys using the quantum keys and makes the combination keys available for distribution (e.g., for non-secret distribution over a public channel). The combination keys facilitate secure communication between two user devices even in the absence of QKD between the two user devices. With the protocols, benefits of QKD are extended to multi-party communication scenarios. In addition, the protocols can retain benefit of QKD even when a trusted authority is offline or a large group seeks to establish secure communication within the group.

  20. Secure multi-party communication with quantum key distribution managed by trusted authority

    DOE Patents [OSTI]

    Hughes, Richard John; Nordholt, Jane Elizabeth; Peterson, Charles Glen

    2015-01-06

    Techniques and tools for implementing protocols for secure multi-party communication after quantum key distribution ("QKD") are described herein. In example implementations, a trusted authority facilitates secure communication between multiple user devices. The trusted authority distributes different quantum keys by QKD under trust relationships with different users. The trusted authority determines combination keys using the quantum keys and makes the combination keys available for distribution (e.g., for non-secret distribution over a public channel). The combination keys facilitate secure communication between two user devices even in the absence of QKD between the two user devices. With the protocols, benefits of QKD are extended to multi-party communication scenarios. In addition, the protocols can retain benefit of QKD even when a trusted authority is offline or a large group seeks to establish secure communication within the group.

  1. Divertor target for magnetic containment device

    DOE Patents [OSTI]

    Luzzi, Jr., Theodore E.

    1982-01-01

    In a plasma containment device of a type having superconducting field coils for magnetically shaping the plasma into approximately the form of a torus, an improved divertor target for removing impurities from a "scrape off" region of the plasma comprises an array of water cooled swirl tubes onto which the scrape off flux is impinged. Impurities reflected from the divertor target are removed from the target region by a conventional vacuum getter system. The swirl tubes are oriented and spaced apart within the divertor region relative to the incident angle of the scrape off flux to cause only one side of each tube to be exposed to the flux to increase the burnout rating of the target. The divertor target plane is oriented relative to the plane of the path of the scrape off flux such that the maximum heat flux onto a swirl tube is less than the tube design flux. The containment device is used to contain the plasma of a tokamak fusion reactor and is applicable to other long pulse plasma containment systems.

  2. Target buffer assessment for accelerator driven transmuters.

    SciTech Connect (OSTI)

    Gohar, Y.

    2002-10-08

    Accelerator driven transmuters use a buffer region to protect the structural and the cladding materials of the transmuter from the radiation damage caused by the high-energy spallation neutrons, to accommodate the coolant channels of the self cooled targets, and to have an insignificant effect on the neutron utilization for the transmutation process. These functions are contradicting with respect to the buffer thickness. An extension of the target region in the axial direction (the proton beam direction) is also required to act as a neutron multiplier for the forward component of the high-energy spallation neutrons and a reflector to minimize the neutron leakage. The buffer assessment was performed as a function of its thickness with different proton energies for a self-cooled Lead-Bismuth Eutectic and a sodium-cooled tungsten targets. The analyses show that the number of generated neutrons per proton has a low sensitivity to the buffer thickness. However, the number of neutrons reaching the transmuter is significantly reduced as the buffer thickness is increased. The transmuter neutrons dominate the nuclear responses in the structural material outside the target buffer. The length of the axial target extension is determined as a function of the proton beam energy.

  3. Focus Series: Program Finds Community "Readiness" Is the Key to More

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Retrofits | Department of Energy Program Finds Community "Readiness" Is the Key to More Retrofits Focus Series: Program Finds Community "Readiness" Is the Key to More Retrofits Focus Series: Program Finds Community "Readiness" Is the Key to More Retrofits, a document posted by the U.S. Department of Energy's (DOE'S) Better Buildings Neighborhood Program. Focus Series: Michigan (284.83 KB) More Documents & Publications Better Buildings Network View | June

  4. Cooling Towers: Understanding Key Components of Cooling Towers and How to

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Improve Water Efficiency | Department of Energy Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve Water Efficiency Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve Water Efficiency Fact sheet covers the key components of cooling towers and how to improve water efficiency. waterfs_coolingtowers.pdf (3.16 MB) More Documents & Publications Guidelines for Estimating Unmetered Industrial Water Use Side Stream Filtration for

  5. California Energy Incentive Programs: An Annual Update on Key Energy Issues

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Financial Opportunities for Federal Sites in California | Department of Energy Energy Incentive Programs: An Annual Update on Key Energy Issues and Financial Opportunities for Federal Sites in California California Energy Incentive Programs: An Annual Update on Key Energy Issues and Financial Opportunities for Federal Sites in California Report from the Federal Energy Management Program discusses an annual update on key energy issues and financial opportunities for federal sites in

  6. Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer

    DOE Patents [OSTI]

    Hu, Zhi; Kuo, Wen-Lin; Neve, Richard M.; Gray, Joe W.

    2012-06-12

    Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.

  7. Spotlight on Key Program Strategies from the Better Buildings Neighborhood Program, Final Evaluation Volume 6

    Broader source: Energy.gov [DOE]

    Final Report: Spotlight on Key Program Strategies from the Better Buildings Neighborhood Program, Final Evaluation Volume 6, American Recovery and Reinvestment Act of 2009, June 2015.

  8. PPPL to launch major upgrade of key fusion energy test facility...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to launch major upgrade of key fusion energy test facility NSTX project will produce most ... of nuclear fusion as a clean, safe and abundant fuel for generating electricity. ...

  9. Small Modular Reactors- Key to Future Nuclear Power Generation in the U.S.

    Office of Energy Efficiency and Renewable Energy (EERE)

    Small Modular Reactors - Key to Future Nuclear Power Generation in the U.S. University of Chicago, Energy Policy Institute at Chicago

  10. LEDSGP/Transportation Toolkit/Key Actions/Create a Baseline ...

    Open Energy Info (EERE)

    a Baseline) Jump to: navigation, search LEDSGP Logo.png Transportation Toolkit Home Tools Training Request Assistance Key Actions for Low-Emission Development in Transportation...

  11. Accelerator breeder with uranium, thorium target

    SciTech Connect (OSTI)

    Takahashi, H.; Powell, J.; Kouts, H.

    1983-01-01

    An accelerator breeder, that uses a low-enriched fuel as the target material, can produce substantial amounts of fissile material and electric power. A study of H/sub 2/O- and D/sub 2/O-cooled, UO/sub 2/, U, (depleted U), or thorium indicates that U-metal fuel produces a good fissile production rate and electrical power of about 60% higher than UO/sub 2/ fuel. Thorium fuel has the same order of magnitude as UO/sub 2/ fuel for fissile-fuel production, but the generating electric power is substantially lower than in a UO/sub 2/ reactor. Enriched UO/sub 2/ fuel increases the generating electric power but not the fissile-material production rate. The Na-cooled breeder target has many advantages over the H/sub 2/O-cooled breeder target.

  12. Decommissioning and PIE of the MEGAPIE spallation target

    SciTech Connect (OSTI)

    Latge, C.; Henry, J.; Wohlmuther, M.; Dai, Y.; Gavillet, D.; Hammer, B.; Heinitz, S.; Neuhausen, J.; Schumann, D.; Thomsen, K.; Tuerler, A.; Wagner, W.; Gessi, A.; Guertin, A.; Konstantinovic, M.; Lindau, R.; Maloy, S.; Saito, S.

    2013-07-01

    A key experiment in the Accelerated Driven Systems roadmap, the MEGAwatt PIlot Experiment (MEGAPIE) (1 MW) was initiated in 1999 in order to design and build a liquid lead-bismuth spallation target, then to operate it into the Swiss spallation neutron facility SINQ at Paul Scherrer Institute. The target has been designed, manufactured, and tested during integral tests, before irradiation carried out end of 2006. During irradiation, neutron and thermo hydraulic measurements were performed allowing deep interpretation of the experiment and validation of the models used during design phase. The decommissioning, Post Irradiation Examinations and waste management phases were defined properly. The phases dedicated to cutting, sampling, cleaning, waste management, samples preparation and shipping to various laboratories were performed by PSI teams: all these phases constitute a huge work, which allows now to perform post-irradiation examination (PIE) of structural material, irradiated in relevant conditions. Preliminary results are presented in the paper, they concern chemical characterization. The following radio-nuclides have been identified by ?-spectrometry: {sup 60}Co, {sup 101}Rh, {sup 102}Rh, {sup 108m}Ag, {sup 110m}Ag, {sup 133}Ba, {sup 172}Hf/Lu, {sup 173}Lu, {sup 194}Hg/Au, {sup 195}Au, {sup 207}Bi. For some of these nuclides the activities can be easily evaluated from ?-spectrometry results ({sup 207}Bi, {sup 194}Hg/Au), while other nuclides can only be determined after chemical separations ({sup 108m}Ag, {sup 110m}Ag, {sup 195}Au, {sup 129}I, {sup 36}Cl and ?-emitting {sup 208-210}Po). The concentration of {sup 129}I is lower than expected. The chemical analysis already performed on spallation and corrosion products in the lead-bismuth eutectic (LBE) are very relevant for further applications of LBE as a spallation media and more generally as a coolant.

  13. A Mathematical Tumor Model with Immune Resistance and Drug Therapy: An Optimal Control Approach

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    De Pillis, L. G.; Radunskaya, A.

    2001-01-01

    We present a competition model of cancer tumor growth that includes both the immune system response and drug therapy. This is a four-population model that includes tumor cells, host cells, immune cells, and drug interaction. We analyze the stability of the drug-free equilibria with respect to the immune response in order to look for target basins of attraction. One of our goals was to simulate qualitatively the asynchronous tumor-drug interaction known as “Jeffs phenomenon.” The model we develop is successful in generating this asynchronous response behavior. Our other goal was to identify treatment protocols that could improve standard pulsed chemotherapymore » regimens. Using optimal control theory with constraints and numerical simulations, we obtain new therapy protocols that we then compare with traditional pulsed periodic treatment. The optimal control generated therapies produce larger oscillations in the tumor population over time. However, by the end of the treatment period, total tumor size is smaller than that achieved through traditional pulsed therapy, and the normal cell population suffers nearly no oscillations.« less

  14. Nuclear Target Ratios data release page

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nuclear Target Ratios data release page "Measurement of ratios of muon neutrino charged-current cross sections on C, Fe, and Pb to CH at neutrino energies 2-20 GeV" Phys. Rev. Lett. 112 (2014) 231801, hep-ex/1403.2103. Data Anciliary files for this result can be found at http://arxiv.org/src/1403.2103v4/anc Anciliary Files include: Cross section ratios as a function of Bjorken x Cross Section ratio as a function of neutrino energy Target Masses used in the experiment Neutrino Flux used

  15. Separation of sodium-22 from irradiated targets

    DOE Patents [OSTI]

    Taylor, Wayne A.; Jamriska, David

    1996-01-01

    A process for selective separation of sodium-22 from an irradiated target including dissolving an irradiated target to form a first solution, contacting the first solution with hydrated antimony pentoxide to selectively separate sodium-22 from the first solution, separating the hydrated antimony pentoxide including the separated sodium-22 from the first solution, dissolving the hydrated antimony pentoxide including the separated sodium-22 in a mineral acid to form a second solution, and, separating the antimony from the sodium-22 in the second solution.

  16. Linear and angular retroreflecting interferometric alignment target

    DOE Patents [OSTI]

    Maxey, L. Curtis

    2001-01-01

    The present invention provides a method and apparatus for measuring both the linear displacement and angular displacement of an object using a linear interferometer system and an optical target comprising a lens, a reflective surface and a retroreflector. The lens, reflecting surface and retroreflector are specifically aligned and fixed in optical connection with one another, creating a single optical target which moves as a unit that provides multi-axis displacement information for the object with which it is associated. This displacement information is useful in many applications including machine tool control systems and laser tracker systems, among others.

  17. ALT-3 Target & CMU Version 4

    SciTech Connect (OSTI)

    Griego, Jeffrey R; Atchison, Walter L.; Holtkamp, David; Oro, David M.; Reinovsky, Robert E.; Rousculp, Christopher L.; Tabaka, Leonard J.

    2012-06-11

    The third Advance Liner Technology (ALT-3) experiment is the next in a long tradition of collaborations between LANL and RFNC/VNIIEF in high-explosive pulsed-power. Here a VNIIEF provided Disk Explosive Magnetic Generator (DEMG) will drive a LANL provided experimental load and diagnostic package. The objective of the experiment is to explore the use of a cylindrical liner-ontarget in tera-Pascal equation of state measurement. This presentation will discuss version 4 of the experimental target and central measuring unit (CMU) along with R & D already performed in fabrication of the target.

  18. Study of Laser Interaction with Thin Targets

    SciTech Connect (OSTI)

    Boley, C D; Cutter, K P; Fochs, S N; Pax, P H; Rotter, M D; Rubenchik, A M; Yamamoto, R M

    2009-03-06

    For many targets of interest, the thickness is small compared to the conduction length during the engagement. In addition, the laser-material interaction region can be treated as flat. We have studied this regime with our 25 kW solid-state laser. We have demonstrated that airflow can reduce by approximately 40% the energy required to break through a thin target. This reduction is caused by the bulging of the softened material and the tearing and removal of the material by aerodynamic forces. We present elastic modeling which explains these results.

  19. Neutron single target spin asymmetries in SIDIS

    SciTech Connect (OSTI)

    Evaristo Cisbani

    2010-04-01

    The experiment E06-010 in Hall A at Jefferson Lab took data between November 2008 and February 2009 to directly measure, for the first time, the pion (and kaon) single "neutron" target-spin asymmetry (SSA) in semi-inclusive DIS from a polarized 3He target. Collins, Sivers (and Pretzelosity) neutron asymmetries are going to be extracted from the measured SSA. Details of the experiment are described together with the preliminary results of the ongoing analysis. Near future Hall A experiments on transverse nucleon spin structure are shorty reviewed.

  20. Table II: Technical Targets for Membranes: Automotive

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    II: Technical Targets for Membranes: Automotive All targets must be achieved simultaneously Characteristics Units Calendar year 2000 status a 2005 2010 Membrane conductivity, operating temperature Ω-cm -1 0.1 0.1 0.1 Room temperature Ω-cm -1 -20 o C Ω-cm -1 Oxygen cross-over b mA/cm 2 5 5 2 Hydrogen cross-over b mA/cm 2 5 5 2 Cost $/kW 50 5 Operating Temperature o C 80 120 120 Durability Hours 1000 d >4000 e >5000 f Survivability c o C -20 -30 -40 Thermal cyclability in presence of