Sample records for key drug target

  1. A Key Target for Diabetes Drugs | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor,...

  2. Computer-Aided Drug Target Search

    E-Print Network [OSTI]

    Chen, Yuzong

    Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery. It can potentially help in several aspects including: (1) determination of unknown therapeutic ...

  3. Chemical signatures and new drug targets for gametocytocidal drug

    E-Print Network [OSTI]

    Arnold, Jonathan

    Chemical signatures and new drug targets for gametocytocidal drug development Wei Sun1 *, Takeshi Q antimalarial drugs are not active against P. falciparum gametocytes, responsible for the spread of malaria screening 5,215 known drugs and compounds. All these compounds were active against three strains

  4. DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL DATA

    E-Print Network [OSTI]

    Zeng, Jianyang "Michael"

    DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL.edu.cn Corresponding author In silico prediction of unknown drug-target interactions (DTIs) has become a popular tool for drug repositioning and drug development. A key challenge in DTI prediction lies in integrating multiple

  5. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  6. 1. Introduction 2. Apicoplast as a drug target

    E-Print Network [OSTI]

    McFadden, Geoff

    1. Introduction 2. Apicoplast as a drug target 3. Conclusion 4. Expert opinion Review Targeting an excellent drug target. Areas covered: This review focuses on the biological role of the apicoplast in the erythrocytic life cycle and what that reveals about existing drug targets. We also discuss the future

  7. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  8. 1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds

    E-Print Network [OSTI]

    Marchiori, Elena

    1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds using a weighted@cs.ru.nl,elenam@cs.ru.nl Abstract In silico discovery of interactions between drug compounds and target proteins is of core importance for improving the efficiency of the laborious and costly experimental determination of drug

  9. Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic

    E-Print Network [OSTI]

    Getoor, Lise

    Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic Shobeir, USA getoor@cs.umd.edu ABSTRACT The high development cost and low success rate of drug dis- covery from appro- ved drugs. Computational methods can be effective in focu- sing efforts for such drug repurposing

  10. Computational Method for Drug Target Search and Application in Drug Discovery

    E-Print Network [OSTI]

    Chen, Yuzong

    Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind ...

  11. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  12. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

    2012-08-28T23:59:59.000Z

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  13. Target Selection for the LBTI Exozodi Key Science Program

    E-Print Network [OSTI]

    Weinberger, Alycia J; Kennedy, Grant M; Roberge, Aki; Defrère, Denis; Hinz, Philip M; Millan-Gabet, Rafael; Rieke, George; Bailey, Vanessa P; Danchi, William C; Haniff, Chris; Mennesson, Bertrand; Serabyn, Eugene; Skemer, Andrew J; Stapelfeldt, Karl R; Wyatt, Mark C

    2015-01-01T23:59:59.000Z

    The Hunt for Observable Signatures of Terrestrial planetary Systems (HOSTS) on the Large Binocular Telescope Interferometer will survey nearby stars for faint emission arising from ~300 K dust (exozodiacal dust), and aims to determine the exozodiacal dust luminosity function. HOSTS results will enable planning for future space telescopes aimed at direct spectroscopy of habitable zone terrestrial planets, as well as greater understanding of the evolution of exozodiacal disks and planetary systems. We lay out here the considerations that lead to the final HOSTS target list. Our target selection strategy maximizes the ability of the survey to constrain the exozodi luminosity function by selecting a combination of stars selected for suitability as targets of future missions and as sensitive exozodi probes. With a survey of approximately 50 stars, we show that HOSTS can enable an understanding of the statistical distribution of warm dust around various types of stars and is robust to the effects of varying levels ...

  14. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01T23:59:59.000Z

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  15. MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells

    E-Print Network [OSTI]

    Gao, Jinming

    MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells Jagadeesh Setti micelle (MFM) system that is encoded with a lung cancer-targeting peptide (LCP), and encapsulated. The LCP-encoded MFM showed significantly increased Rv 6-dependent cell targeting in H2009 lung cancer

  16. Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery

    E-Print Network [OSTI]

    Tan, Mei Chee

    The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

  17. REVIEWS Drug Discovery Today Volume 12, Numbers 1/2 January 2007 Drug-target identification in Drosophila

    E-Print Network [OSTI]

    Perrimon, Norbert

    the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery studies over the years has relied on the ease of growing this organism and the powerful genetic tools such as the insulin, epidermal growth factor, transforming growth factor b, Wnt, Hedgehog, JAK/STAT and Notch pathways

  18. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool ofTopo II: An Enzyme Target for

  19. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool ofTopo II: An Enzyme Target forTopo II: An

  20. drug discovery drug discovery

    E-Print Network [OSTI]

    drug discovery at Purdue #12;drug discovery 2 #12;drug discovery 3 Introduction The drug discovery and innovative drug candidates to treat chronic and acute illnesses. Our researchers also continue to be invested in various approaches to drug discovery, which include understanding of drug targets for future drug

  1. International Experience with Key Program Elements of IndustrialEnergy Efficiency or Greenhouse Gas Emissions Reduction Target-SettingPrograms

    SciTech Connect (OSTI)

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-02-02T23:59:59.000Z

    Target-setting agreements, also known as voluntary ornegotiated agreements, have been used by a number of governments as amechanism for promoting energy efficiency within the industrial sector. Arecent survey of such target-setting agreement programs identified 23energy efficiency or GHG emissions reduction voluntary agreement programsin 18 countries. International best practice related to target-settingagreement programs calls for establishment of a coordinated set ofpolicies that provide strong economic incentives as well as technical andfinancial support to participating industries. The key program elementsof a target-setting program are the target-setting process,identification of energy-saving technologies and measures usingenergy-energy efficiency guidebooks and benchmarking as well as byconducting energy-efficiency audits, development of an energy-savingsaction plan, development and implementation of energy managementprotocols, development of incentives and supporting policies, monitoringprogress toward targets, and program evaluation. This report firstprovides a description of three key target-setting agreement programs andthen describes international experience with the key program elementsthat comprise such programs using information from the three keytarget-setting programs as well as from other international programsrelated to industrial energy efficiency or GHG emissionsreductions.

  2. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Forte, Trudy

    2011-04-28T23:59:59.000Z

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  3. Current Drug Targets, 2007, 8, 15-30 15 1389-4501/07 $50.00+.00 2007 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    McFadden, Geoff

    Current Drug Targets, 2007, 8, 15-30 15 1389-4501/07 $50.00+.00 © 2007 Bentham Science Publishers Ltd. Fatty Acid Biosynthesis as a Drug Target in Apicomplexan Parasites C.D. Goodman* and G.I. Mc impacts on much of the world's population. The increasing prevalence of drug resistant parasites

  4. Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.

    2012-08-31T23:59:59.000Z

    was found to induce marked tumor regression. The discovery of nitrogen mustard as a novel anticancer drug resulted in a great deal of optimism that cancer could finally be cured. A burst of research activity to develop new anticancer drugs therefore... of activity against normal cells. Indeed, many novel anticancer agents continue to be identified, but few find clinical utility due to unacceptable toxicity [17], a clear indicator that there is a need for a screening approach that can identify potent drugs...

  5. Key Elements of and Materials Performance Targets for Highly Insulating Window Frames

    SciTech Connect (OSTI)

    Gustavsen, Arild; Grynning, Steinar; Arasteh, Dariush; Jelle, Bjorn Petter; Goudey, Howdy

    2011-03-28T23:59:59.000Z

    The thermal performance of windows is important for energy efficient buildings. Windows typically account for about 30-50 percent of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U-factor of their opaque counterparts (wall, roof and floor constructions). In well insulated buildings the U-factor of walls, roofs an floors can be between 0.1-0.2 W/(m2K). The best windows have U-values of about 0.7-1.0. It is therefore obvious that the U-factor of windows needs to be reduced, even though looking at the whole energy balance for windows (i.e. solar gains minus transmission losses) makes the picture more complex.In high performance windows the frame design and material use is of utmost importance, as the frame performance is usually the limiting factor for reducing the total window U-factor further. This paper describes simulation studies analyzing the effects on frame and edge-of-glass U-factors of different surface emissivities as well as frame material and spacer conductivities. The goal of this work is to define materials research targets for window frame components that will result in better frame thermal performance than is exhibited by the best products available on the market today.

  6. Structure-based drug mechanism study and inhibitor design targeting tuberculosis 

    E-Print Network [OSTI]

    Wang, Feng

    2009-05-15T23:59:59.000Z

    The increase of multi-drug resistant and extensively drug resistant tuberculosis (TB) cases makes it urgent to develop a new generation of TB drugs to counter resistance and shorten treatment. Structural biology, which ...

  7. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01T23:59:59.000Z

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

  8. Example 1: Bioenergetic analysis of combining mitochondria-targeted drugs with 2-deoxyglucose in breast cancer cells

    E-Print Network [OSTI]

    Example 1: Bioenergetic analysis of combining mitochondria-targeted drugs with 2- deoxyglucose in breast cancer cells OVERVIEW The MCW Cancer Center Bioenergetics Shared Resource opened in January 2012 in MFRC 2013. The purpose of the Bioenergetics Shared Resource is four- fold: investigate cancer cell

  9. UNCORRECTEDPROOF Please cite this article in press as: Arinaminpathy, Y. et al. Computational analysis of membrane proteins: the largest class of drug targets, Drug Discov Today (2009), doi:10.1016/

    E-Print Network [OSTI]

    Gerstein, Mark

    2009-01-01T23:59:59.000Z

    analysis of membrane proteins: the largest class of drug targets, Drug Discov Today (2009), doi:10.1016/ j.drudis.2009.08.006 Drug Discovery Today Volume 00, Number 00 September 2006 REVIEWS Computational analysis disorders, such as hypertension, congestive heart failure, stroke and cancer. On a similar scale, genetic

  10. Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion

    SciTech Connect (OSTI)

    Knobloch, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland); Portier, C.J. [Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 (United States); Levionnois, O.L. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Theurillat, R. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Thormann, W. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Spadavecchia, C. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Mevissen, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland)]. E-mail: meike.mevissen@vpi.unibe.ch

    2006-11-01T23:59:59.000Z

    Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 {mu}g/ml S-ketamine over 120 min under isoflurane anesthesia was performed in Shetland ponies. A quantitative electromyographic assessment of the NWR was done before, during and after the TCI. Plasma levels of R-/S-ketamine and R-/S-norketamine were determined by enantioselective capillary electrophoresis. These data and two additional data sets from bolus studies were used to build a PBPk model for ketamine in ponies. The peak-to-peak amplitude and the duration of the NWR decreased significantly during TCI and returned slowly toward baseline values after the end of TCI. The PBPk model provides reliable prediction of plasma and tissue levels of R- and S-ketamine and R- and S-norketamine. Furthermore, biotransformation of ketamine takes place in the liver and in the lung via first-pass metabolism. Plasma concentrations of S-norketamine were higher compared to R-norketamine during TCI at all time points. Analysis of the data suggested identical biotransformation rates from the parent compounds to the principle metabolites (R- and S-norketamine) but different downstream metabolism to further metabolites. The PBPk model can provide predictions of R- and S-ketamine and norketamine concentrations in other clinical settings (e.g. horses)

  11. Intracellular Distribution-based Anticancer Drug Targeting: Exploiting a Lysosomal Acidification Defect Associated with Cancer Cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.; Jacobs, Damon T.; Forrest, M. Laird; Krise, Jeffrey P.

    2010-09-09T23:59:59.000Z

    previously described a concept for a novel drug delivery platform that relies on the propensity of drugs with optimal physicochemical properties to distribute differently in normal versus cancer cells due to differences in intracellular pH gradients...

  12. Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs

    E-Print Network [OSTI]

    Tan, Weihong

    drugs (11, 12, 18­21). Nucleic acid aptamers are single-stranded oligonucleotides with unique intra cells (22­26). Re- cent biotechnological advancements have led to a variety of tar- geted drug transport blocks to construct sophisticated nucleic acid-based nanomaterials, or laborious and i

  13. Abstract--Wave energy will have a key role in meeting re-newable energy targets en route to a low carbon economy. How-

    E-Print Network [OSTI]

    Harrison, Gareth

    1 Abstract--Wave energy will have a key role in meeting re- newable energy targets en route will impact on wave energy conversion. Where the resource is restricted there may be reductions in energy the sensitivity of wave energy production and econom- ics to changes in climate. Index Terms--Wave energy

  14. Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme

    E-Print Network [OSTI]

    Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

    2006-01-01T23:59:59.000Z

    Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

  15. In Vivo Monitoring of Tissue Pharmacokinetics of Liposome/Drug Using MRI: Illustration of Targeted

    E-Print Network [OSTI]

    if MnSO4/doxoru- bicin (DOX) loaded liposomes could be used for in vivo moni- toring of liposome concentration distributions as well as drug release by using a novel MnSO4-doxorubicin (DOX) formulation is used to load DOX (4). This method of loading uses the metal concentration gra- dient (4

  16. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    Affairs (DEFRA), 2005. UK Emissions Trading Scheme. http://targets through the UK Emissions Trading Scheme. 6 Table 1is to be adjusted for emissions trading. The reports must be

  17. Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: A persistence gene and protein drug target

    SciTech Connect (OSTI)

    Kantardjieff, K A; Vasquez, C; Castro, P; Warfel, N M; Rho, B; Lekin, T; Kim, C; Segelke, B W; Terwilliger, T C; Rupp, B

    2004-09-24T23:59:59.000Z

    The 1.9 {angstrom} native structure of pyrimidine biosynthesis regulatory protein encoded by the Mycobacterium tuberculosis pyrR gene (Rv1379) is reported. Because pyrimidine biosynthesis is an essential step in the progression of TB, pyrR is an attractive antitubercular drug target. The Mycobacterium tuberculosis pyrR gene (Rv1379) encodes a protein that regulates expression of pyrimidine nucleotide biosynthesis (pyr) genes in a UMP-dependent manner. Because pyrimidine biosynthesis is an essential step in the progression of TB, the gene product pyrR is an attractive antitubercular drug target. We report the 1.9 {angstrom} native structure of Mtb pyrR determined by the TB Structural Genomics Consortium facilities (PDB entry 1W30) in trigonal space group P3{sub 1}21, with cell dimensions at 120K of a = 66.64 {angstrom}, c = 154.72 {angstrom}, and two molecules in the asymmetric unit. The 3D structure and residual uracil phosphoribosyltransferase activity point to a common PRTase ancestor for pyrR. However, while PRPP and UMP binding sites have been retained in Mtb pyrR, a novel dimer interaction among subunits creates a deep, positively charged cleft capable of binding pyr mRNA. In silico screening of pyrimidine nucleoside analogs has revealed a number of potential leads compounds that, if bound to Mtb pyrR, could facilitate transcriptional attenuation, particularly cyclopentenyl nucleosides.

  18. Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design.

    E-Print Network [OSTI]

    Ah Young, AP; Koehl, A; Cascio, D; Egea, PF

    2015-01-01T23:59:59.000Z

    falciparum: Targeting protein folding and secretion forfalciparum: targeting protein folding and secretion for

  19. Current Drug Targets, 2006, 7, 000-000 1 1389-4501/06 $50.00+.00 2006 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    and bring about a prolonged effect. By its binding to plasmatic proteins, resveratrol also exhibits a prolonged effect. Interestingly, low doses of res- veratrol can sensitize to low doses of cytotoxic drugs or chemotherapeutic strategies and is believed to be a novel weapon for new therapeutic strategies. Key Words

  20. An acoustically-driven biochip - Impact of flow on the cell-association of targeted drug carriers

    E-Print Network [OSTI]

    Fillafer, Christian; Neumann, Jürgen; Guttenberg, Zeno; Dissauer, Silke; Lichtscheidl, Irene; Wirth, Michael; Gabor, Franz; Schneider, Matthias; 10.1039/B906006E

    2011-01-01T23:59:59.000Z

    The interaction of targeted drug carriers with epithelial and endothelial barriers in vivo is largely determined by the dynamics of the body fluids. To simulate these conditions in binding assays, a fully biocompatible in vitro model was developed which can accurately mimic a wide range of physiological flow conditions on a thumbnail-format cell-chip. This acoustically-driven microfluidic system was used to study the interaction characteristics of protein-coated particles with cells. Poly(D,L-lactide-co-glycolide) (PLGA) microparticles (2.86 {\\pm} 0.95 {\\mu}m) were conjugated with wheat germ agglutinin (WGA-MP, cytoadhesive protein) or bovine serum albumin (BSA-MP, nonspecific protein) and their binding to epithelial cell monolayers was investigated under stationary and flow conditions. While mean numbers of 1500 {\\pm} 307 mm-2 WGA-MP and 94 {\\pm} 64 mm-2 BSA-MP respectively were detected to be cell-bound in the stationary setup, incubation at increasing flow velocities increasingly antagonized the attachment...

  1. Crucial stages of protein folding through a solvable model: Predicting target sites

    E-Print Network [OSTI]

    Cecconi, Fabio

    Crucial stages of protein folding through a solvable model: Predicting target sites for enzyme. Keywords: Protein-folding modeling; prediction of key folding sites; HIV-1 protease; drug resistance One

  2. Abstract --This paper studies the use of the innovative concept of MRI-targeted drug delivery platform for robotic

    E-Print Network [OSTI]

    Mavroidis, Constantinos

    platform for robotic targeting of magnetized aerosol in the lungs. The goal is to increase dramatically presence in healthy lung tissues. For this purpose, a parametric analysis is conducted to specify the magnetic forces required to efficiently target magnetized liposomal agents to the lungs. The force

  3. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26T23:59:59.000Z

    properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

  4. Smart drug discovery leveraging innovative technologies and predictive knowledge

    E-Print Network [OSTI]

    Cai, Long

    the risk of failure. Owing to the integration of key in silico and experimental tools. A positive aspect of this paradigm shift includes faster,strategic decision making with respect to drug targets from the human genome pro- vides opportunities for detailed analysis of structure and function

  5. Drug-drug similarity networks for anti-cancer drug discovery Case studies on Breast Cancer, Colorectal Cancer and Leukemia

    E-Print Network [OSTI]

    Zhou, Yaoqi

    Drug-drug similarity networks for anti-cancer drug discovery ­ Case studies on Breast Cancer the decades, the medical industry has been challenged with the issue of producing drugs that would avoid sidetracking to other targets (off-targets) and keep away from harmful side effects (drug adverse reactions

  6. Key distributionKey distribution Key distribution, symmetric encryption

    E-Print Network [OSTI]

    Fisher, Michael

    COMP 522 Key distributionKey distribution COMP 522 Key distribution, symmetric encryption From in a secure way and must keep the key secure" · Important issue: how to distribute secret keys? COMP 522 Key distribution, manual delivery For two parties A and B: · A key could be created by A and delivered physically

  7. Key Agency Targets Summary _FY 2012_.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn12electron beamJoin2015JustKateKent5 B O N N E V I L L E P O W

  8. Assess the key physics that underpins high-hydro coupling-efficiency in NDCX-II experiments and high-gain heavy ion direct drive target designs using proven hydro codes like HYDRA

    E-Print Network [OSTI]

    Barnard, J. J.

    2010-01-01T23:59:59.000Z

    physics that underpins high-hydro coupling-efficiency in N Dtarget designs using proven hydro codes like H Y D R A . byF E targets, we have studied hydro and implosion efficiency

  9. The x-ray crystal structure analysis of the complex formed by trypsin with the thrombin inhibitor 4-chloro-3-ethoxy-7-guanidinoisocoumarin: implications for mechanism and drug design

    E-Print Network [OSTI]

    Chow, Margaret Mei-Shin

    1990-01-01T23:59:59.000Z

    been subjected to extensive study as targets of drug and inhibitor design for a variety of reasons. Chief among them is their ubiquitous presence and involvement in key fh j l ~ f tyl d f t ~h' h ' t physiological processes, ranging from digestion... specific proteases and inhibitors could then serve as a paradigm for molecular modelling, and for drug design and synthesis in other lesser known enzyme-substrate/inhibitor systems. Two main classes of inhibitors have been studied as potential...

  10. Public Key Cryptography and Key Management

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-02-15T23:59:59.000Z

    The use and management of certificate-based public key cryptography for the Department of Energy (DOE) requires the establishment of a public key infrastructure (PKI). This chapter defines the policy related to roles, requirements, and responsibilities for establishing and maintaining a DOE PKI and the documentation necessary to ensure that all certificates are managed in a manner that maintains the overall trust required to support a viable PKI. Canceled by DOE N 251.112.

  11. Key Milestones/Outlook

    Broader source: Energy.gov [DOE]

    Key Milestones/Outlook per the Department of Energy 2015 Congressional Budget Request, Environmental Management, March 2014

  12. Targeting of drugs and nanoparticles to tumors

    E-Print Network [OSTI]

    Ruoslahti, Erkki

    The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as ...

  13. Drug Delivery DOI: 10.1002/anie.200802260

    E-Print Network [OSTI]

    Zare, Richard N.

    Drug Delivery DOI: 10.1002/anie.200802260 Sustained Release of Drugs Dispersed in Polymer) was observed for up to 40 days with up to 90% drug recovery. In vivo bioluminescence imaging of transgenic mice, represents a new drug delivery approach with great potential, particularly if particles can be targeted

  14. SIXTEENTH INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN DRUG

    E-Print Network [OSTI]

    Tipple, Brett

    SIXTEENTH INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN DRUG DELIVERY SYSTEMS Register on-line: www on Recent Advances in Drug Delivery Systems "Drug Delivery: the penetrating challenges" Pioneering event in the field New drug targeting methods Improved delivery strategies Imaging and treatment combinations

  15. B. Comp Dissertation SNP Data Integration and Analysis for Drug-

    E-Print Network [OSTI]

    Wong, Limsoon

    B. Comp Dissertation SNP Data Integration and Analysis for Drug- Response Biomarker Discovery 2008/2009 #12;i B. Comp Dissertation SNP Data Integration and Analysis for Drug- Response methods to develop drugs targeted at various diseases. To maximize drug viability and profit, one

  16. Quantum dense key distribution

    SciTech Connect (OSTI)

    Degiovanni, I.P.; Ruo Berchera, I.; Castelletto, S.; Rastello, M.L.; Bovino, F.A.; Colla, A.M.; Castagnoli, G. [Istituto Elettrotecnico Nazionale G. Ferraris, Strada delle Cacce 91, 10135 Torino (Italy); ELSAG SpA, Via Puccini 2, 16154, Genova (Italy)

    2004-03-01T23:59:59.000Z

    This paper proposes a protocol for quantum dense key distribution. This protocol embeds the benefits of a quantum dense coding and a quantum key distribution and is able to generate shared secret keys four times more efficiently than the Bennet-Brassard 1984 protocol. We hereinafter prove the security of this scheme against individual eavesdropping attacks, and we present preliminary experimental results, showing its feasibility.

  17. Key Events Timeline

    Broader source: Energy.gov [DOE]

    This document lists key events beginning with the April 20 fire on the Deepwater Horizon through July 28th. Updated July 28, 2010.

  18. Key Request (Last) (First)

    E-Print Network [OSTI]

    Carrington, Emily

    will be accessing. For Johnson Hall exterior door access bring a copy of this form to the Earth & Space SciencesKey Request Form Name: (Last) (First) Contact Info Keys Cardswipe UW Email: Hitchcock Exterior Door Room:_________ Room:_________ Johnson Room:_________ Room:_________ Kincaid Exterior Door Room

  19. Optical key system

    DOE Patents [OSTI]

    Hagans, Karla G. (Livermore, CA); Clough, Robert E. (Danville, CA)

    2000-01-01T23:59:59.000Z

    An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

  20. Drug delivery Combinatorial Drug Conjugation Enables Nanoparticle

    E-Print Network [OSTI]

    Zhang, Liangfang

    Drug delivery Combinatorial Drug Conjugation Enables Nanoparticle Dual-Drug Delivery Santosh Aryal, Che-Ming Jack Hu, and Liangfang Zhang* A new approach to loading multiple drugs onto the same drug through hydrolyzable linkers to form drug conjugates, is reported. In contrast to loading individual types

  1. Key Elements of and Materials Performance Targets for Highly

    E-Print Network [OSTI]

    and Technology, Høgskoleringen 7A, NO-7491 Trondheim, Norway Abstract The thermal performance of windows of the transmission losses though the building envelope, even if their area fraction of the envelope is far less. The reason for this can be found by comparing the thermal transmittance (U-factor) of windows to the U

  2. Cryptographic Key Management System

    SciTech Connect (OSTI)

    No, author

    2014-02-21T23:59:59.000Z

    This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene#12;ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

  3. Rational Mutagenesis to Support Structure-based Drug Design: MAPKAP Kinase 2 as a Case Study

    SciTech Connect (OSTI)

    M Argiriadi; S Sousa; D Banach; D Marcotte; T Xiang; M Tomlinson; M Demers; C Harris; S Kwak; et al.

    2011-12-31T23:59:59.000Z

    Structure-based drug design (SBDD) can provide valuable guidance to drug discovery programs. Robust construct design and expression, protein purification and characterization, protein crystallization, and high-resolution diffraction are all needed for rapid, iterative inhibitor design. We describe here robust methods to support SBDD on an oral anti-cytokine drug target, human MAPKAP kinase 2 (MK2). Our goal was to obtain useful diffraction data with a large number of chemically diverse lead compounds. Although MK2 structures and structural methods have been reported previously, reproducibility was low and improved methods were needed. Our construct design strategy had four tactics: N- and C-terminal variations; entropy-reducing surface mutations; activation loop deletions; and pseudoactivation mutations. Generic, high-throughput methods for cloning and expression were coupled with automated liquid dispensing for the rapid testing of crystallization conditions with minimal sample requirements. Initial results led to development of a novel, customized robotic crystallization screen that yielded MK2/inhibitor complex crystals under many conditions in seven crystal forms. In all, 44 MK2 constructs were generated, {approx}500 crystals were tested for diffraction, and {approx}30 structures were determined, delivering high-impact structural data to support our MK2 drug design effort. Key lessons included setting reasonable criteria for construct performance and prioritization, a willingness to design and use customized crystallization screens, and, crucially, initiation of high-throughput construct exploration very early in the drug discovery process.

  4. Bioenergy Key Publications

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureCommentsEnergyand SustainedBio-OilBioenergy 2015 AgendaBioenergyKEY

  5. NETL: Key Staff

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |IsLoveReferenceAgenda Workshop AgendaGraphic of aEnergy SystemsKey

  6. NSR Key Number Retrieval

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated CodesTransparency VisitSilver Toyota PriusNSR Key Number Retrieval Pease

  7. Key-shift transmission

    SciTech Connect (OSTI)

    Nemoto, S.

    1989-03-07T23:59:59.000Z

    A key-shift transmission is described, characterized by the speed-change shaft being divided into a pair of trough-shaped shaft halves each having an arched inner surface which defines a part of a cylindrical bore extending axially through the speed-change shaft thereby the shaft being formed into a hollow shaft, and by each of the shaft halves including a pair of flattened end surfaces which extend axially of each shaft half at both sides of the inner surface, one of the end surfaces having thereon an axially elongated projection and the other of the end surfaces having herein an axially elongated recess of a depth smaller than the height of the projection. The pair of shaft halves are engaged to each other co-rotatably by fitting the projections of the respective shaft halves into the recesses of the respective shaft halves so as to form in an outer surface of the speed-change shaft a pair of elongated axial grooves which are located radially outwardly of the elongated projections of the respective shaft halves and between the flattened end surfaces of the respective shaft halves. A pair of the shift keys are disposed within the pair of elongated axial grooves.

  8. Key recycling in authentication

    E-Print Network [OSTI]

    Christopher Portmann

    2014-09-29T23:59:59.000Z

    In their seminal work on authentication, Wegman and Carter propose that to authenticate multiple messages, it is sufficient to reuse the same hash function as long as each tag is encrypted with a one-time pad. They argue that because the one-time pad is perfectly hiding, the hash function used remains completely unknown to the adversary. Since their proof is not composable, we revisit it using a composable security framework. It turns out that the above argument is insufficient: if the adversary learns whether a corrupted message was accepted or rejected, information about the hash function is leaked, and after a bounded finite amount of rounds it is completely known. We show however that this leak is very small: Wegman and Carter's protocol is still $\\epsilon$-secure, if $\\epsilon$-almost strongly universal$_2$ hash functions are used. This implies that the secret key corresponding to the choice of hash function can be reused in the next round of authentication without any additional error than this $\\epsilon$. We also show that if the players have a mild form of synchronization, namely that the receiver knows when a message should be received, the key can be recycled for any arbitrary task, not only new rounds of authentication.

  9. Team Building Toolkit KEYS -Keys to Enhance Your Supervisory Success

    E-Print Network [OSTI]

    Walker, Matthew P.

    Team Building Toolkit KEYS - Keys to Enhance Your Supervisory Success University of California to Enhance Your Supervisory Success 2 | P a g e Table of Contents Stages of Team Development ................................................................................................ 4 Team Building at a Glance

  10. Target assembly

    DOE Patents [OSTI]

    Lewis, Richard A. (Falls Church, VA)

    1980-01-01T23:59:59.000Z

    A target for a proton beam which is capable of generating neutrons for absorption in a breeding blanket includes a plurality of solid pins formed of a neutron emissive target material disposed parallel to the path of the beam and which are arranged axially in a plurality of layers so that pins in each layer are offset with respect to pins in all other layers, enough layers being used so that each proton in the beam will strike at least one pin with means being provided to cool the pins. For a 300 mA, 1 GeV beam (300 MW), stainless steel pins, 12 inches long and 0.23 inches in diameter are arranged in triangular array in six layers with one sixth of the pins in each layer, the number of pins being such that the entire cross sectional area of the beam is covered by the pins with minimum overlap of pins.

  11. IFE Target Fabrication, Delivery, and Cost Estimates

    E-Print Network [OSTI]

    synergism but key differences that lead to specific technologies Heavy Ion Fusion Laser Fusion Z-Pinch IFE of this talk....... 1. IFE target technology builds upon the larger ICF program - Not starting from "zero" for IFE - Large effort for NIC fosters efficiency (e.g., foam shells) 2. The recent IFE target technology

  12. TARGET STATION INFRASTRUCTURE THE CNGS EXPERIENCE

    E-Print Network [OSTI]

    McDonald, Kirk

    of Aluminum Water cooled Current: 150kA (horn) ­ 180 kA (reflector) Pulse duration 7ms #12;Key elements Remote handling Remote station for radiation survey in the target chamber #12;CNGS Target Area I per cooling circuit 2007 run radiation effects on ventilation system electronics broken flexible stripline

  13. Drug Overdose Deaths, Hospitalizations,

    E-Print Network [OSTI]

    MacAdam, Keith

    Drug Overdose Deaths, Hospitalizations, and Emergency Department Visits in Kentucky, 2000 - 2012 #12; Kentucky Injury Preven on and Research Center Drug Overdose Deaths, Hospitaliza ons . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Drug overdose deaths, 20002012

  14. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  15. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  16. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)

    1993-01-01T23:59:59.000Z

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  17. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02T23:59:59.000Z

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  18. Accelerator target

    DOE Patents [OSTI]

    Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

    1999-06-29T23:59:59.000Z

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

  19. Accelerator target

    DOE Patents [OSTI]

    Schlyer, David J. (Bellport, NY); Ferrieri, Richard A. (Patchogue, NY); Koehler, Conrad (Miller Place, NY)

    1999-01-01T23:59:59.000Z

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  20. Drug interactions evaluation: An integrated part of risk assessment of therapeutics

    SciTech Connect (OSTI)

    Zhang, Lei; Reynolds, Kellie S.; Zhao, Ping [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States); Huang, Shiew-Mei, E-mail: shiewmei.huang@fda.hhs.go [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States)

    2010-03-01T23:59:59.000Z

    Pharmacokinetic drug interactions can lead to serious adverse events or decreased drug efficacy. The evaluation of a new molecular entity's (NME's) drug-drug interaction potential is an integral part of risk assessment during drug development and regulatory review. Alteration of activities of enzymes or transporters involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by concomitant drugs may alter drug exposure, which can impact response (safety or efficacy). The recent Food and Drug Administration (FDA) draft drug interaction guidance ( (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072101.pdf)) highlights the methodologies and criteria that may be used to guide drug interaction evaluation by industry and regulatory agencies and to construct informative labeling for health practitioner and patients. In addition, the Food and Drug Administration established a 'Drug Development and Drug Interactions' website to provide up-to-date information regarding evaluation of drug interactions ( (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm080499.htm)). This review summarizes key elements in the FDA drug interaction guidance and new scientific developments that can guide the evaluation of drug-drug interactions during the drug development process.

  1. Target-guided synthesis approach to the discovery of novel bivalent inhibitors of Glutathione Transferases 

    E-Print Network [OSTI]

    Clipson, Alexandra Jayne

    2012-06-22T23:59:59.000Z

    Target-guided synthesis is an approach to drug discovery that uses the biological target as a template to direct synthesis of its own best inhibitors from small molecule fragments. The process bridges the gap between ...

  2. Diversity & Flexibility Key to Sustainability

    Broader source: Energy.gov [DOE]

    Plenary V: Biofuels and Sustainability: Acknowledging Challenges and Confronting MisconceptionsDiversity & Flexibility Key to SustainabilityDavid Babson, Senior Fuels Engineer, Union of...

  3. Engineered nanomedicine for myeloma and bone microenvironment targeting

    E-Print Network [OSTI]

    Swami, Archana

    Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains a crucial oncologic challenge due to issues of drug availability ...

  4. LBNL-63807, REV. 1 International Experience with Key

    E-Print Network [OSTI]

    -setting agreement programs calls for establishment of a coordinated set of policies that provide strong economic incentives as well as technical and financial support to participating industries. The key program elements protocols, development of incentives and supporting policies, monitoring progress toward targets

  5. Tomography increases key rates of quantum-key-distribution protocols

    E-Print Network [OSTI]

    Shun Watanabe; Ryutaroh Matsumoto; Tomohiko Uyematsu

    2008-07-22T23:59:59.000Z

    We construct a practically implementable classical processing for the BB84 protocol and the six-state protocol that fully utilizes the accurate channel estimation method, which is also known as the quantum tomography. Our proposed processing yields at least as high key rate as the standard processing by Shor and Preskill. We show two examples of quantum channels over which the key rate of our proposed processing is strictly higher than the standard processing. In the second example, the BB84 protocol with our proposed processing yields a positive key rate even though the so-called error rate is higher than the 25% limit.

  6. Quantum key distribution with key extracted from basis information

    E-Print Network [OSTI]

    Xiongfeng Ma

    2014-10-20T23:59:59.000Z

    In conventional quantum key distribution protocols, the secure key is normally extracted from the measurement outcomes of the system. Here, a different approach is proposed, where the secure key is extracted from the measurement bases, rather than outcomes. Compared to the original Bennett-Brassard-1984 protocol, the proposed protocol involves no hardware change but modifications in data postprocessing. We show that this protocol is more robust against detector efficiency attacks and photon-number-splitting attacks when practical detectors and photon sources are used.

  7. Finite key analysis for symmetric attacks in quantum key distribution

    SciTech Connect (OSTI)

    Meyer, Tim; Kampermann, Hermann; Kleinmann, Matthias; Bruss, Dagmar [Institut fuer Theoretische Physik III, Heinrich-Heine-Universitaet Duesseldorf, D-40225 Duesseldorf (Germany)

    2006-10-15T23:59:59.000Z

    We introduce a constructive method to calculate the achievable secret key rate for a generic class of quantum key distribution protocols, when only a finite number n of signals is given. Our approach is applicable to all scenarios in which the quantum state shared by Alice and Bob is known. In particular, we consider the six state protocol with symmetric eavesdropping attacks, and show that for a small number of signals, i.e., below n{approx}10{sup 4}, the finite key rate differs significantly from the asymptotic value for n{yields}{infinity}. However, for larger n, a good approximation of the asymptotic value is found. We also study secret key rates for protocols using higher-dimensional quantum systems.

  8. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01T23:59:59.000Z

    and the risk of illicit drug use: the Adverse Childhoodalcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.

  9. Annu. Rev. Med. 2002. 53:595614 RATIONAL APPROACH TO AIDS DRUG DESIGN

    E-Print Network [OSTI]

    Annu. Rev. Med. 2002. 53:595­614 RATIONAL APPROACH TO AIDS DRUG DESIGN THROUGH STRUCTURAL BIOLOGY than a dozen drugs in the past 15 years for the treatment of AIDS offer an excellent example of progress in the field of rational drug design. At this time, the principal targets are reverse

  10. MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design

    E-Print Network [OSTI]

    Powers, Robert

    MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design by Coupling to bind a target protein while obtaining structure-related information as part of a struc- ture-based drug for drug discovery is the utilization of a biological assay to screen a large library of compounds (>100

  11. DOI: 10.1002/cmdc.200800122 HER-2-Targeted NanoparticleAffibody Bioconjugates for Cancer Therapy

    E-Print Network [OSTI]

    Zhang, Liangfang

    shown that this class of molecule can se- lectively bind to HER-2-overexpressing cell lines (SKBR-3 drug toxicity, and maintaining a relatively high concentration of drug at the site of interest.[1 drugs to diseased cells. The first examples of targeted NPs were reported in 1980, and despite nearly

  12. Key Issues | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment ofLetter Report: I11IG002RTC3WASTE-TO-ENERGY:KenKeriKey Issues Key

  13. Predicting selective drug targets in cancer through metabolic networks

    E-Print Network [OSTI]

    Ruppin, Eytan

    facilitating the uptake and conversion of nutrients into biomass (Vander Heiden et al, 2009). Numerous studies adapt their metabolism to facilitate biomass formation to enable proli- feration suggests that it may- growing microorganisms (Price et al, 2004).

  14. Targeted Drug Delivery To Leukocytes with ICAM-1 Derived Peptides

    E-Print Network [OSTI]

    Majumdar, Sumit

    2008-07-15T23:59:59.000Z

    cells by receptor mediated endocytosis and passive diffusion, respectively. High hydrophobicity of DOX-cIBR was proposed to be responsible for its energy-independent entry (chapter 2). To check the effect of hydrophobicity on internalization, two...

  15. Gastric H,K-ATPase as a drug target

    E-Print Network [OSTI]

    Shin, Jai M; Sachs, G

    2006-01-01T23:59:59.000Z

    Review article: Helicobacter pylori and gastro- oesophagealWL: The treatment of Helicobacter pylori infection in thewith infection by Helicobacter pylori and the realization

  16. Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System 

    E-Print Network [OSTI]

    Yu, Xiao

    2012-07-16T23:59:59.000Z

    Page 1 Chemical structure of paclitaxel; reproduced and cited ............................. 2 2 Schematic of the layer by layer (LbL) procedure....................................... 6 3 Chemical structures of chitosan and dextran... of the PAA solution was close to its pKa at 4.5. Ionic strength in the deposition and washing solutions also increased the thickness of PAA/PAH coatings.15 Figure 2. Schematic of the LbL procedure. Besides the electrostatic interactions, other...

  17. Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System

    E-Print Network [OSTI]

    Yu, Xiao

    2012-07-16T23:59:59.000Z

    +/- 10 nm were fabricated, characterized and then encapsulated in synthetic / biomacromolecule shell chitosan, dextran-sulfate using a layer by layer (LbL) self-assembly technique. Surface modifications were performed by covalently conjugating with poly...

  18. Gastric H,K-ATPase as a drug target

    E-Print Network [OSTI]

    Shin, Jai M; Sachs, G

    2006-01-01T23:59:59.000Z

    cations. J Biol Chem Fukushima Y, Nakao M: Changes inChem 1980;255(16):7813-9. Fukushima Y, Post RL: Binding of

  19. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool of tomorrowChemCamInnovationDepartmentTopo

  20. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool of

  1. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesisAppliances » Top Innovative Scienceastrophysics

  2. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01T23:59:59.000Z

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  3. Key-Insulated Symmetric Key Cryptography and Mitigating Attacks against Cryptographic Cloud Software

    E-Print Network [OSTI]

    Dodis, Yevgeniy

    Key-Insulated Symmetric Key Cryptography and Mitigating Attacks against Cryptographic Cloud- sociated cryptographic keys in their entirety. In this paper, we investigate key-insulated symmetric key. To illustrate the feasibility of key-insulated symmetric key cryptography, we also report a proof

  4. Chemoinformatics in drug development

    E-Print Network [OSTI]

    2012-05-01T23:59:59.000Z

    ORAL PRESENTATION Open Access Chemoinformatics in drug development Colin R Groom From 7th German Conference on Chemoinformatics: 25 CIC-Workshop Goslar, Germany. 6-8 November 2011 It would be unimaginable to prosecute a drug discovery program... to the contributions that can be made as a candidate molecule progresses towards becoming part of a drug substance. This presentation will highlight the opportunities for the application of chemoinformatics techniques to the area of pharmaceutical materials science, a...

  5. First SNS Target Replacement

    E-Print Network [OSTI]

    McDonald, Kirk

    First SNS Target Replacement Experience M. Dayton, M. Rennich, Van Graves, J. DeVore Presented by T.S. Department of Energy AHIP Workshop Oct. 2009 Overview · Initial Target Replacement · Target Maintenance-Battelle for the U.S. Department of Energy AHIP Workshop Oct. 2009 First SNS Target Replacement · Replacement

  6. MECO Production Target Developments

    E-Print Network [OSTI]

    McDonald, Kirk

    be reoptimized Tungsten target Simulations of design parameters with GEANT3 indicate that both production targetMECO Production Target Developments James L. Popp University of California, Irvine NuFact'03 Columbia, June, 2003 #12;June, 2003J.L.Popp, UCI MECO Production Target 2 MECO Collaboration Institute

  7. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, R.J.

    1984-10-10T23:59:59.000Z

    A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

  8. Electrically charged targets

    DOE Patents [OSTI]

    Goodman, Ronald K. (Livermore, CA); Hunt, Angus L. (Alamo, CA)

    1984-01-01T23:59:59.000Z

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  9. Nanoparticle drug delivery enhances the cytotoxicity of hydrophobichydrophilic drug conjugates

    E-Print Network [OSTI]

    Zhang, Liangfang

    Nanoparticle drug delivery enhances the cytotoxicity of hydrophobic­hydrophilic drug conjugates, Accepted 4th October 2011 DOI: 10.1039/c1jm13834k We report a drug conjugation approach to concurrently load both hydrophobic and hydrophilic drugs into the same drug delivery nanocarrier in a precisely

  10. Key Opportunities and Challenges for Program Sustainability ...

    Energy Savers [EERE]

    Key Opportunities and Challenges for Program Sustainability Key Opportunities and Challenges for Program Sustainability Better Buildings Neighborhood Program, Peer Exchange Call:...

  11. Drug delivery Sustained Drug Release from Non-eroding Nanoporous

    E-Print Network [OSTI]

    Sridhar, Srinivas

    drug, doxorubicin (Dox), from different non-eroding nanopor- ous coatings. Detailed studies of drug, in the case of small molecules such as Dox, enzymes would not interfere with the drug and hence the elution

  12. Fixed drug eruption caused by the Japanese herbal drug kakkonto

    E-Print Network [OSTI]

    Furuichi, Megumi; Hara, Hiroshi; Asano, Yukie; Makino, Teruhiko; Shimizu, Tadamichi

    2010-01-01T23:59:59.000Z

    Topical provocation of fixed drug eruption. Br J Dermatol.neglected offender for fixed drug eruptions. Eur J Dermatoloral and non-oral herbal drugs may cause FDE. References 1.

  13. Drug Use and Drug Policy in a Prohibition Regime

    E-Print Network [OSTI]

    MacCoun, Robert; Martin, Karin D.

    2008-01-01T23:59:59.000Z

    Prisoners (prior to offense), Drug-related Emergency RoomVisits, 2007 DAWN All illicit drugs Marijuana Cocaine Crack2/4/2008 - 41 Other Sentence Drug Sentence Federal Prisoners

  14. Magnetically attached sputter targets

    DOE Patents [OSTI]

    Makowiecki, D.M.; McKernan, M.A.

    1994-02-15T23:59:59.000Z

    An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

  15. Statistical Agent Based Modelization of the Phenomenon of Drug Abuse

    E-Print Network [OSTI]

    Di Clemente, Riccardo; 10.1038/srep00532

    2012-01-01T23:59:59.000Z

    We introduce a statistical agent based model to describe the phenomenon of drug abuse and its dynamical evolution at the individual and global level. The agents are heterogeneous with respect to their intrinsic inclination to drugs, to their budget attitude and social environment. The various levels of drug use were inspired by the professional description of the phenomenon and this permits a direct comparison with all available data. We show that certain elements have a great importance to start the use of drugs, for example the rare events in the personal experiences which permit to overcame the barrier of drug use occasionally. The analysis of how the system reacts to perturbations is very important to understand its key elements and it provides strategies for effective policy making. The present model represents the first step of a realistic description of this phenomenon and can be easily generalized in various directions.

  16. NREL: Energy Analysis - Key Activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated CodesTransparency Visit | NationalWebmaster To contactK-12BSM -JEDI JobsKey

  17. Key Activities | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov.Energy02.pdf7 OPAMEnergyInvestigativeCoggin AboutofKathleen HoganKenKeyAbout

  18. Key Activities | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015of 2005 at IowaSecretaryDepartmentJointof Energy 30,ANDNovember 17,KeyThe

  19. Key Activities | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015of 2005 at IowaSecretaryDepartmentJointof Energy 30,ANDNovember 17,KeyTheThe

  20. Quantum Key Distribution with Qubit Pairs

    E-Print Network [OSTI]

    Mohd Asad Siddiqui; Tabish Qureshi

    2014-07-17T23:59:59.000Z

    We propose a new Quantum Key Distribution method in which Alice sends pairs of qubits to Bob, each in one of four possible states. Bob uses one qubit to generate a secure key and the other to generate an auxiliary key. For each pair he randomly decides which qubit to use for which key. The auxiliary key has to be added to Bob's secure key in order to match Alice's secure key. This scheme provides an additional layer of security over the standard BB84 protocol.

  1. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01T23:59:59.000Z

    alcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.outcomes in an indicated drug prevention program for high-

  2. Anticoagulation Drug Therapy: A Review

    E-Print Network [OSTI]

    Harter, Katherine; Levine, Michael; Henderson, Sean O.

    2015-01-01T23:59:59.000Z

    et al. Anticoagulation Drug Therapy: A Review 15. NishijimaRandomized antiplatelet drugs. In: Goodman & Gilman’s The2008;24:2757-65. Cardiovasc Drugs. 2006;6:265-85. 34. Nordt

  3. COLLEGE AVE CAMPUS (CAC) KEY PICK UP

    E-Print Network [OSTI]

    COLLEGE AVE CAMPUS (CAC) KEY PICK UP NOTE TO ALL STUDENTS: ONLY YOU CAN PICK UP YOUR KEY. You in and key pick up. If you are unable to pick up your key by 5:00 p.m. on September 1st , please make prior in Clothier Hall on CAC. Keys not picked up during the above-noted hours can be picked up at the Housing

  4. High Power Cryogenic Targets

    SciTech Connect (OSTI)

    Gregory Smith

    2011-08-01T23:59:59.000Z

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  5. The design and characterization of a microcalorimeter to aid drug discovery

    E-Print Network [OSTI]

    McEuen, Scott Jacob

    2008-01-01T23:59:59.000Z

    This thesis describes the design and characterization of a microcalorimeter used to aid drug discovery. There are four key functional requirements for the device: (1.) 8.4 [mu]J energy resolution, (2.) 20 [mu]L reactant ...

  6. Drug Information Chart Notes Drug ad (intrinsic bias)

    E-Print Network [OSTI]

    Abolmaesumi, Purang

    Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company Dosage Same or different? A drug in a different dosage can be used for a different therapy. Precautions Check for pregnancy A complete book on drugs in pregnancy and lactation in bibliography. (unbiased

  7. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

    SciTech Connect (OSTI)

    Hast, Michael A.; Nichols, Connie B.; Armstrong, Stephanie M.; Kelly, Shannon M.; Hellinga, Homme W.; Alspaugh, J. Andrew; Beese, Lorena S. (Duke)

    2012-09-17T23:59:59.000Z

    Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals, including AIDS patients and transplant recipients. Few antifungals can treat C. neoformans infections, and drug resistance is increasing. Protein farnesyltransferase (FTase) catalyzes post-translational lipidation of key signal transduction proteins and is essential in C. neoformans. We present a multidisciplinary study validating C. neoformans FTase (CnFTase) as a drug target, showing that several anticancer FTase inhibitors with disparate scaffolds can inhibit C. neoformans and suggesting structure-based strategies for further optimization of these leads. Structural studies are an essential element for species-specific inhibitor development strategies by revealing similarities and differences between pathogen and host orthologs that can be exploited. We, therefore, present eight crystal structures of CnFTase that define the enzymatic reaction cycle, basis of ligand selection, and structurally divergent regions of the active site. Crystal structures of clinically important anticancer FTase inhibitors in complex with CnFTase reveal opportunities for optimization of selectivity for the fungal enzyme by modifying functional groups that interact with structurally diverse regions. A substrate-induced conformational change in CnFTase is observed as part of the reaction cycle, a feature that is mechanistically distinct from human FTase. Our combined structural and functional studies provide a framework for developing FTase inhibitors to treat invasive fungal infections.

  8. The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier

    E-Print Network [OSTI]

    Wang, Jing

    2008-01-01T23:59:59.000Z

    It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is ...

  9. Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies

    E-Print Network [OSTI]

    Wong, Albert, S.M. Massachusetts Institute of Technology

    2009-01-01T23:59:59.000Z

    'Smart' targeted drug carriers have long been sought after in the treatment of epidermal growth factor (EGF)-overexpressing cancers due to the potential advantages, relative to current clinical therapies (generally limited ...

  10. Functionalized Zirconium Phosphate Nano Platelets - From Surface Design to Drug Delivery 

    E-Print Network [OSTI]

    Mukherjee, Atashi

    2014-05-30T23:59:59.000Z

    the intended target or compartment. This dissertation will focus on the analytical characterization of zirconium phosphate (ZrP) in both alpha and theta phases as a drug delivery matrix utilizing multiple unique and novel analytical techniques. In the first...

  11. Title Clinically informative measures of the effect of drugs or other interventions

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Title Clinically informative measures of the effect of drugs or other interventions Authors L'Information Médicale, Bordeaux, France Suissa: Division of Clinical Epidemiology, Royal Victoria Hospital; Department Running head Measures of the effect of drugs Key words Randomized clinical trials; Cohort studies

  12. Exploring Key Orientations of Small Molecules to Disrupt Protein-protein Interactions 

    E-Print Network [OSTI]

    Ko, Eunhwa

    2012-07-16T23:59:59.000Z

    with long-linkers bound to TrkA or TrkC receptor and showed partial antagonism for the receptors. Other mimics were conjugated with cytotoxic compounds and they were used for TrkC targeted drug delivery. The last group of bivalent mimics previously showed...

  13. Answering Key Fuel Cycle Questions

    SciTech Connect (OSTI)

    Steven J. Piet; Brent W. Dixon; J. Stephen Herring; David E. Shropshire; Mary Lou Dunzik-Gougar

    2003-10-01T23:59:59.000Z

    The Advanced Fuel Cycle Initiative (AFCI) program has both “outcome” and “process” goals because it must address both waste already accumulating as well as completing the fuel cycle in connection with advanced nuclear power plant concepts. The outcome objectives are waste geological repository capacity and cost, energy security and sustainability, proliferation resistance, fuel cycle economics, and safety. The process objectives are readiness to proceed and adaptability and robustness in the face of uncertainties. A classic decision-making approach to such a multi-attribute problem would be to weight individual quantified criteria and calculate an overall figure of merit. This is inappropriate for several reasons. First, the goals are not independent. Second, the importance of different goals varies among stakeholders. Third, the importance of different goals is likely to vary with time, especially the “energy future.” Fourth, some key considerations are not easily or meaningfully quantifiable at present. Instead, at this point, we have developed 16 questions the AFCI program should answer and suggest an approach of determining for each whether relevant options improve meeting each of the program goals. We find that it is not always clear which option is best for a specific question and specific goal; this helps identify key issues for future work. In general, we suggest attempting to create as many win-win decisions (options that are attractive or neutral to most goals) as possible. Thus, to help clarify why the program is exploring the options it is, and to set the stage for future narrowing of options, we have developed 16 questions, as follows: · What are the AFCI program goals? · Which potential waste disposition approaches do we plan for? · What are the major separations, transmutation, and fuel options? · How do we address proliferation resistance? · Which potential energy futures do we plan for? · What potential external triggers do we plan for? · Should we separate uranium? · If we separate uranium, should we recycle it, store it or dispose of it? · Is it practical to plan to fabricate and handle “hot” fuel? · Which transuranic elements (TRU) should be separated and transmuted? · Of those TRU separated, which should be transmuted together? · Should we separate and/or transmute Cs and Sr isotopes that dominate near-term repository heating? · Should we separate and/or transmute very long-lived Tc and I isotopes? · Which separation technology? · What mix of transmutation technologies? · What fuel technology best supports the above decisions?

  14. Non-traditional platinum compounds for improved cellular accumulation and tumor targeting

    E-Print Network [OSTI]

    Lovejoy, Katherine Summer, 1981-

    2009-01-01T23:59:59.000Z

    Chapter 1. Introduction to Non-Traditional Platinum Compounds for Improved Uptake, Oral Bioavailability, and Tumor Targeting The path to more potent platinum anticancer drugs with fewer side effects lies in the exploration ...

  15. A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy

    E-Print Network [OSTI]

    Valencia, Pedro M. (Pedro Miguel)

    2013-01-01T23:59:59.000Z

    The use of nanotechnology to engineer drug delivery vehicles comprised of controlled release polymers with targeting molecules has the potential to revolutionize cancer therapy, among other diseases. Although a myriad of ...

  16. Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang,

    E-Print Network [OSTI]

    Zhang, Liangfang

    functionalization of the polymeric NPs with the A10 2 -fluoropyrimidine ribonucleic acid (RNA) aptamers nanoparticles, polymer conjugation chemistry, targeted drug delivery, sur- face functionalization, aptamersChapter 11 Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang

  17. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

    E-Print Network [OSTI]

    Babu, M. Madan

    of drug resistance. Historically, this important endeavor has been primarily focused on case-by-case studies of antibacterial resistance, but technological developments have resulted in several genome-wide approaches to drug target discovery. Examples of these include studies of gene expression changes after

  18. Quantum Key Distribution with Screening and Analyzing

    E-Print Network [OSTI]

    Won-Ho Kye

    2006-10-04T23:59:59.000Z

    We propose a quantum key distribution scheme by using screening angles and analyzing detectors which enable to notice the presence of Eve who eavesdrops the quantum channel, as the revised protocol of the recent quantum key distribution [Phys. Rev. Lett. 95, 040501 (2005)]. We discuss the security of the proposed quantum key distribution against various attacks including impersonation attack and Trojan Horse attack.

  19. Lightweight Key Establishment for Distributed Networking Environments

    E-Print Network [OSTI]

    Martin, Keith

    / COSIC Seminar 2007 Keith Martin #12;Lightweight Key Establishment/Introduction The plan 1. Wireless sensor networks 2. A key establishment framework 3. Key establishment for grids COSIC Seminar 2007 Keith Establishment/Wireless sensor networks The "classical" scenario COSIC Seminar 2007 Keith Martin #12;Lightweight

  20. An Implantable Bio-Micro-system for Drug Monitoring

    E-Print Network [OSTI]

    De Micheli, Giovanni

    An Implantable Bio-Micro-system for Drug Monitoring Sara Ghoreishizadeh, Enver G. Kilinc, Camilla of the implantable monitoring system for long- term duration has many challenges. First, a multi-target biosen- sor coil; (ii) A power manage- ment IC dealing with the energy source of the implantable microsystem

  1. TARGET SPECIES Table 1. Terrestrial target species.

    E-Print Network [OSTI]

    that have only one or a very few number of key ecological functions. Functional specialist species could = Critical functional link species, species that are the only ones that perform a specific ecological Merganser Boreal Toad Wolverine FS Horned Grebe Long-toed Salamander CFLS BIRDS House Finch CFLS Northern

  2. Target Cost Management Strategy

    E-Print Network [OSTI]

    Okano, Hiroshi

    1996-01-01T23:59:59.000Z

    Target cost management (TCM) is an innovation of Japanese management accounting system and by common sense has been considered with great interest by practitioners. Nowadays, TCM related

  3. Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth

    E-Print Network [OSTI]

    of the disease. Thus, drugs that selectively target cancer stem cells offer great promise for cancer treatment and chemotherapeutic drugs to improve treatment of patients with breast (and possibly other) cancers. [Cancer Res 2009;69(19):7507­11] Introduction Chemotherapeutic treatments for cancer can effectively reduce tumor mass, but the disease often

  4. Fractalkine Targeting with a Receptor-Mimicking Peptide-Amphiphile

    E-Print Network [OSTI]

    Kokkoli, Efie

    . Kasinskas, Anastasia Mardilovich, and Ashish Garg Department of Chemical Engineering and Materials Science drug delivery systems driven by a strong need in clinical practice. Advances in materials science to the target tissue.2 Liposomes have been investigated extensively and long-circulating liposomes (stealth lipo

  5. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 Cooling Channel in both walls for draining · Downstream end can be shortened, assuming the window cooling is adequate #12;11 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 Remote Handling

  6. Counterfactual quantum key distribution with high efficiency

    SciTech Connect (OSTI)

    Sun Ying [State Key Laboratory of Networking and SwitchingTechnology, Beijing University of Posts and Telecommunications, Beijing 100876 (China); Beijing Electronic Science and Technology Institute, Beijing 100070 (China); Wen Qiaoyan [State Key Laboratory of Networking and SwitchingTechnology, Beijing University of Posts and Telecommunications, Beijing 100876 (China)

    2010-11-15T23:59:59.000Z

    In a counterfactual quantum key distribution scheme, a secret key can be generated merely by transmitting the split vacuum pulses of single particles. We improve the efficiency of the first quantum key distribution scheme based on the counterfactual phenomenon. This scheme not only achieves the same security level as the original one but also has higher efficiency. We also analyze how to achieve the optimal efficiency under various conditions.

  7. Essays on Drug Use and Crime

    E-Print Network [OSTI]

    Deza, Monica

    2012-01-01T23:59:59.000Z

    Prinz. A. , 1997, Do European drugs policies mater? Economicruin? Sequences of initiation to drugs and crime in Britain.and P. Grimes, 2001, Adolescent Drug Use and Educational

  8. Florida Keys Electric Cooperative- Residential Rebate Program

    Broader source: Energy.gov [DOE]

    Florida Keys Electric Cooperative offers residential members rebates for installing energy efficient measures. To qualify for rebates, members must first call FKEC and make an appointment for a...

  9. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases...

  10. Structural Genomics and Drug Discovery for Infectious Diseases

    SciTech Connect (OSTI)

    Anderson, W.F.

    2010-09-03T23:59:59.000Z

    The application of structural genomics methods and approaches to proteins from organisms causing infectious diseases is making available the three dimensional structures of many proteins that are potential drug targets and laying the groundwork for structure aided drug discovery efforts. There are a number of structural genomics projects with a focus on pathogens that have been initiated worldwide. The Center for Structural Genomics of Infectious Diseases (CSGID) was recently established to apply state-of-the-art high throughput structural biology technologies to the characterization of proteins from the National Institute for Allergy and Infectious Diseases (NIAID) category A-C pathogens and organisms causing emerging, or re-emerging infectious diseases. The target selection process emphasizes potential biomedical benefits. Selected proteins include known drug targets and their homologs, essential enzymes, virulence factors and vaccine candidates. The Center also provides a structure determination service for the infectious disease scientific community. The ultimate goal is to generate a library of structures that are available to the scientific community and can serve as a starting point for further research and structure aided drug discovery for infectious diseases. To achieve this goal, the CSGID will determine protein crystal structures of 400 proteins and protein-ligand complexes using proven, rapid, highly integrated, and cost-effective methods for such determination, primarily by X-ray crystallography. High throughput crystallographic structure determination is greatly aided by frequent, convenient access to high-performance beamlines at third-generation synchrotron X-ray sources.

  11. Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer

    E-Print Network [OSTI]

    Toyokawa, Gouji; Masuda, Ken; Daigo, Yataro; Cho, Hyun-Soo; Yoshimatsu, Masanori; Takawa, Masashi; Hayami, Shinya; Maejima, Kazuhiro; Chino, Makoto; Field, Helen I; Neal, David E; Tsuchiya, Eiju; Ponder, Bruce A J; Maehara, Yoshihiko; Nakamura, Yusuke; Hamamoto, Ryuji

    2011-05-28T23:59:59.000Z

    Abstract Background The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This can only be achieved if the drug used is against a specific target...

  12. Neutronic Characterization of the Megapie Target

    E-Print Network [OSTI]

    Stefano Panebianco; Olivier Bringer; Pavel Bokov; Sebastien Chabod; Frederic Chartier; Emmeric Dupont; Diane Dore; Xavier Ledoux; Alain Letourneau; Ludovic Oriol; Aurelien Prevost; Danas Ridikas; Jean-Christian Toussaint

    2007-10-31T23:59:59.000Z

    The MEGAPIE project is one of the key experiments towards the feasibility of Accelerator Driven Systems. On-line operation and post-irradiation analysis will provide the scientific community with unique data on the behavior of a liquid spallation target under realistic irradiation conditions. A good neutronics performance of such a target is of primary importance towards an intense neutron source, where an extended liquid metal loop requires some dedicated verifications related to the delayed neutron activity of the irradiated PbBi. In this paper we report on the experimental characterization of the MEGAPIE neutronics in terms of the prompt neutron (PN) flux inside the target and the delayed neutron (DN) flux on the top of it. For the PN measurements, a complex detector, made of 8 microscopic fission chambers, has been built and installed in the central part of the target to measure the absolute neutron flux and its spatial distribution. Moreover, integral information on the neutron energy distribution as a function of the position along the beam axis could be extracted, providing integral constraints on the neutron production models implemented in transport codes such as MCNPX. For the DN measurement, we used a standard 3He counter and we acquired data during the start-up phase of the target irradiation in order to take sufficient statistics at variable beam power. Experimental results obtained on the PN flux characteristics and their comparison with MCNPX simulations are presented, together with a preliminary analysis of the DN decay time spectrum.

  13. SNS Target Systems Operational

    E-Print Network [OSTI]

    McDonald, Kirk

    a failed gas seal on the shaft and leaking oil seals but has operated well since then · The moderator 7.5 k First target replacement · No observed corrosion · Internal Boroscope examination in progress · ~ 50 mm

  14. Model Comparison: A Key Challenge for Transformation Testing and Version Control in Model Driven Software Development

    E-Print Network [OSTI]

    Gray, Jeffrey G.

    Model Comparison: A Key Challenge for Transformation Testing and Version Control in Model Driven practices associated with model transformation testing and version control of models. 1. Introduction target model). #12;· Version Control Tools do not Match the Structural Nature of Models An essential

  15. Secure key distribution by swapping quantum entanglement

    SciTech Connect (OSTI)

    Song, Daegene [National Institute of Standards and Technology, 100 Bureau Drive, MS 8910, Gaithersburg, Maryland 20899 (United States)

    2004-03-01T23:59:59.000Z

    We report two key distribution schemes achieved by swapping quantum entanglement. Using two Bell states, two bits of secret key can be shared between two distant parties that play symmetric and equal roles. We also address eavesdropping attacks against the schemes.

  16. On quantum key distribution using ququarts

    SciTech Connect (OSTI)

    Kulik, S. P., E-mail: Sergei.Kulik@gmail.com; Shurupov, A. P. [Moscow State University (Russian Federation)

    2007-05-15T23:59:59.000Z

    A comparative analysis of quantum key distribution protocols using qubits and ququarts as information carriers is presented. Several schemes of incoherent attacks that can be used by an eavesdropper to obtain secret information are considered. The errors induced by the eavesdropper are analyzed for several key distribution protocols.

  17. Key Elements of and Materials Performance Targets for Highly Insulating Window Frames

    E-Print Network [OSTI]

    Gustavsen, Arild

    2012-01-01T23:59:59.000Z

    in light green. 2.5 Window Frame E (PVC) Window frame Eis polyvinyl chloride (PVC). We performed calculations forspacer = 0.25?0.1 W/(mK) ? pvc = 0.9 W/(mK), ? eff. ,spacer

  18. Key Elements of and Materials Performance Targets for Highly Insulating Window Frames

    E-Print Network [OSTI]

    Gustavsen, Arild

    2012-01-01T23:59:59.000Z

    of Thermal Performance of the Exterior Envelopes of Wholethermal transmittance (U-factor) of the building envelope,envelope is far less. The reason for this can be found by comparing the thermal

  19. Key Elements of and Materials Performance Targets for Highly Insulating Window Frames

    E-Print Network [OSTI]

    Gustavsen, Arild

    2012-01-01T23:59:59.000Z

    finite-element method (FEM) program, THERM (Finlayson et al. , 1998), to solve the conductive heat-transfer

  20. Proceedings of the workshop on polarized targets in storage rings

    SciTech Connect (OSTI)

    Holt, R.J. (ed.)

    1984-08-01T23:59:59.000Z

    Polarization phenomena have played an increasingly important part in the study of nuclei and nucleons in recent years. Polarization studies have been hampered by the relatively few and rather fragile polarized targets which are presently available. The concept of polarized gas targets in storage rings opens a much wider range of possibilities than is available in the external target geometry. This novel method will represent a considerable advance in nuclear physics and will continue to receive much attention in plans for future facilities. An internal, polarized-target station is being planned for the cooler ring at the Indiana University Cyclotron Facility. Internal targets are compatible with recent designs of electron accelerators proposed by the Massachusetts Institute of Technology and the Southeastern Universities Research Association. The key to nuclear-science programs based on internal targets pivots on recent developments in polarized atomic beam methods, which include the more recent laser-driven polarized targets. The workshop drew together a unique group of physicists in the fields of high-energy, nuclear and atomic physics. The meeting was organized in a manner that stimulated discussion among the 58 participants and focused on developments in polarized target technology and the underlying atomic physics. An impressive array of future possibilities for polarized targets as well as current developments in polarized target technology were discussed at the workshop. Abstracts of individual items from the workshop were prepared separately for the data base.

  1. Consistent Query Answering Of Conjunctive Queries Under Primary Key Constraints

    E-Print Network [OSTI]

    Pema, Enela

    2014-01-01T23:59:59.000Z

    Queries and Primary Key Constraints . . . . . . . . . .of Employee w.r.t. the primary key SSN ? {name, salary} . .query answering under primary keys: a characterization of

  2. Communications Drug Delivery

    E-Print Network [OSTI]

    Tan, Weihong

    ] Further, the strategy based on targeting a specific binding site is impeded by the heterogeneity of tumors exhibit pH values between 6.15 and 7.40 (the latter value representing the mean pH value of arterial blood of these polymeric nanoparticle systems is time-consuming and requires a technical knowledge of synthesis. Recently

  3. USE OF DRUG ELUTING STENTS AS A FUNCTION OF PREDICTED BENEFIT: CLINICAL AND ECONOMIC IMPLICATIONS OF CURRENT PRACTICE

    E-Print Network [OSTI]

    Amin, Amit P.

    2011-12-31T23:59:59.000Z

    Background: Benefits of drug-eluting stents (DES) in percutaneous coronary intervention (PCI) are greatest in those at the highest risk of target vessel revascularization (TVR). While DES reduce restenosis, they cost more than bare metal stents (BMS...

  4. Captured key electrical safety lockout system

    SciTech Connect (OSTI)

    Darimont, Daniel E. (Aurora, IL)

    1995-01-01T23:59:59.000Z

    A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member's second position corresponds to the preselected position at which the key can be removed from and inserted into the lock.

  5. Captured key electrical safety lockout system

    DOE Patents [OSTI]

    Darimont, D.E.

    1995-10-31T23:59:59.000Z

    A safety lockout apparatus for an electrical circuit includes an electrical switch, a key, a lock and a blocking mechanism. The electrical switch is movable between an ON position at which the electrical circuit is energized and an OFF position at which the electrical circuit is deactivated. The lock is adapted to receive the key and is rotatable among a plurality of positions by the key. The key is only insertable and removable when the lock is at a preselected position. The lock is maintained in the preselected position when the key is removed from the lock. The blocking mechanism physically maintains the switch in its OFF position when the key is removed from the lock. The blocking mechanism preferably includes a member driven by the lock between a first position at which the electrical switch is movable between its ON and OFF positions and a second position at which the member physically maintains the electrical switch in its OFF position. Advantageously, the driven member`s second position corresponds to the preselected position at which the key can be removed from and inserted into the lock. 7 figs.

  6. Experimental study of high speed polarization-coding quantum key distribution with sifted-key

    E-Print Network [OSTI]

    and links 1. C. H. Bennet and G. Brassard, "Quantum cryptography: Public key distribution and coin tossing

  7. September 11, 2012 NIST Key Management Workshop 2012 Secure Key Storage

    E-Print Network [OSTI]

    September 11, 2012 NIST Key Management Workshop 2012 Secure Key Storage and True Random Number Storage via PUFs - Main Idea - Reliability - Randomness -- InstantiationsInstantiations 3. True Random, including side channel resistance ° Trusted security policy routines ° Secure and authentic key storage

  8. Cooled particle accelerator target

    DOE Patents [OSTI]

    Degtiarenko, Pavel V.

    2005-06-14T23:59:59.000Z

    A novel particle beam target comprising: a rotating target disc mounted on a retainer and thermally coupled to a first array of spaced-apart parallel plate fins that extend radially inwardly from the retainer and mesh without physical contact with a second array of spaced-apart parallel plate fins that extend radially outwardly from and are thermally coupled to a cooling mechanism capable of removing heat from said second array of spaced-apart fins and located within the first array of spaced-apart parallel fins. Radiant thermal exchange between the two arrays of parallel plate fins provides removal of heat from the rotating disc. A method of cooling the rotating target is also described.

  9. Foam encapsulated targets

    DOE Patents [OSTI]

    Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

    1983-01-01T23:59:59.000Z

    Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

  10. Targeted polypeptide degradation

    DOE Patents [OSTI]

    Church, George M. (Brookline, MA); Janse, Daniel M. (Brookline, MA)

    2008-05-13T23:59:59.000Z

    This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

  11. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) Target 1 Flight Path° flightTargetL -

  12. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) Target 1 Flight Path° flightTargetL - -

  13. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) Target 1 Flight Path° flightTargetL - -

  14. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) Target 1 Flight Path° flightTargetL - - -

  15. Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster

    E-Print Network [OSTI]

    Slattery, Matthew

    Annotation of regulatory elements and identification of the transcription-related factors (TRFs) targeting these elements are key steps in understanding how cells interpret their genetic blueprint and their environment ...

  16. Motion dazzle and the effects of target patterning on capture success

    E-Print Network [OSTI]

    Hughes, Anna E.; Troscianko, Jolyon; Stevens, Martin

    2014-09-13T23:59:59.000Z

    capture, but are not uniquely difficult to catch, with luminance matched grey targets also showing a similar capture rate. We show that key factors in making capture easier are a lack of average background luminance matching and having trackable ‘features...

  17. Key Implications of the Global Economic Environment

    E-Print Network [OSTI]

    Lansky, Joshua

    Key Implications of the Global Economic Environment For PCT Filings: A Survey of the Issues DMI...............................................................................9 Annex 1: Incentives for Patent Filing: The Analytical Framework...........................11 I-1 Intellectual property, innovation, and economic growth.................................13 2-2 Individual

  18. Extracting secret keys from integrated circuits

    E-Print Network [OSTI]

    Lim, Daihyun, 1976-

    2004-01-01T23:59:59.000Z

    Modern cryptographic protocols are based on the premise that only authorized participants can obtain secret keys and access to information systems. However, various kinds of tampering methods have been devised to extract ...

  19. BACK TO BASICS: YOUR KEYS TO SAFE

    E-Print Network [OSTI]

    Kirschner, Denise

    BACK TO BASICS: YOUR KEYS TO SAFE DRIVING FINE-TUNE THE FUNDAMENTALS DRIVE SAFELY WORK WEEK: FRIDAY an occasional refresher. In fact, most company fleet safety programs emphasize basic skills and defensive

  20. Mutual Dependence for Secret Key Agreement

    E-Print Network [OSTI]

    Chan, Chung

    A mutual dependence expression is established for the secret key agreement problem when all users are active. In certain source networks, the expression can be interpreted as certain notions of connectivity and network ...

  1. Multipartite secret key distillation and bound entanglement

    E-Print Network [OSTI]

    Remigiusz Augusiak; Pawel Horodecki

    2009-09-25T23:59:59.000Z

    Recently it has been shown that quantum cryptography beyond pure entanglement distillation is possible and a paradigm for the associated protocols has been established. Here we systematically generalize the whole paradigm to the multipartite scenario. We provide constructions of new classes of multipartite bound entangled states, i.e., those with underlying twisted GHZ structure and nonzero distillable cryptographic key. We quantitatively estimate the key from below with help of the privacy squeezing technique.

  2. Multipartite secret key distillation and bound entanglement

    SciTech Connect (OSTI)

    Augusiak, Remigiusz; Horodecki, Pawel [Faculty of Applied Physics and Mathematics, Gdansk University of Technology, Narutowicza 11/12, 80-952 Gdansk (Poland) and ICFO-Institute Ciencies Fotoniques, Mediterranean Technology Park, 08860 Castelldefels (Barcelona) (Spain); Faculty of Applied Physics and Mathematics, Gdansk University of Technology, Narutowicza 11/12, 80-952 Gdansk (Poland)

    2009-10-15T23:59:59.000Z

    Recently it has been shown that quantum cryptography beyond pure entanglement distillation is possible and a paradigm for the associated protocols has been established. Here we systematically generalize the whole paradigm to the multipartite scenario. We provide constructions of new classes of multipartite bound entangled states, i.e., those with underlying twisted Greenberger-Horne-Zeilinger (GHZ) structure and nonzero distillable cryptographic key. We quantitatively estimate the key from below with the help of the privacy squeezing technique.

  3. informedRx Preferred Drug List -Effective July 1, 2012 Preferred Drug List

    E-Print Network [OSTI]

    Scharer, John E.

    informedRx Preferred Drug List - Effective July 1, 2012 Preferred Drug List Brand name drugs are listed in CAPITAL letters and generic drugs are listed in lowercase italics. Generic drugs are preferred, if available. If generic drugs are available and not listed on the formulary, but the brand name drug is

  4. Effects of a Highway Improvement Project on Florida key Deer

    E-Print Network [OSTI]

    Parker, Israel D.; Braden, Anthony W.; Lopez, Roel R.; Silvy, Nova J.; Davis, Donald S.; Owen, Catherine B.

    2007-01-01T23:59:59.000Z

    the primary inter-island roadway in the Florida Keys. DVCsprimary source of mortality for the endangered Florida Key

  5. Future Fixed Target Facilities

    SciTech Connect (OSTI)

    Melnitchouk, Wolodymyr

    2009-01-01T23:59:59.000Z

    We review plans for future fixed target lepton- and hadron-scattering facilities, including the 12 GeV upgraded CEBAF accelerator at Jefferson Lab, neutrino beam facilities at Fermilab, and the antiproton PANDA facility at FAIR. We also briefly review recent theoretical developments which will aid in the interpretation of the data expected from these facilities.

  6. Targeted radionuclide therapy

    SciTech Connect (OSTI)

    Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F. [Radiology Division, City of Hope National Medical Center, Duarte, California 91010 (United States); Internal Medicine, University of California Davis Medical Center, 1508 Alhambra Boulevard, Suite 3100, Sacramento, California 95816 (United States); Department of Radiation Oncology, Wallace Tumor Institute WTI No. 117, University of Alabama at Birmingham, Birmingham, Alabama 35294 (United States)

    2008-07-15T23:59:59.000Z

    Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

  7. Title: Early and global estimation of microvascular target organ damage in hypertension by use of innovative software

    E-Print Network [OSTI]

    Markatos, Evangelos P.

    Title: Early and global estimation of microvascular target organ damage in hypertension by use-mail: artriant@hotmail.com Disclosure: none Conflicts of interest: none Key Words: hypertension, target organ cardiovascular risk assessment and early #12;identification of hypertensive target organ damage is continuously

  8. Solid Target Options S. Childress

    E-Print Network [OSTI]

    McDonald, Kirk

    power is higher than for existing solid target designs - but not by a large factor. · NuMI graphite beam power) · High beam power solid targets frequently use higher z materials for increased yield plusSolid Target Options NuFACT'00 S. Childress Solid Target Options · The choice of a primary beam

  9. ISAC target vacuum system

    SciTech Connect (OSTI)

    Yosifov, Dimo; Sekachev, Igor [TRIUMF, Canada's National Laboratory for Particle and Nuclear Physics, Vancouver, British Columbia V6T 2A3 (Canada)

    2006-07-15T23:59:59.000Z

    The Isotope Separator and Accelerator (ISAC) facility at TRIUMF has been in full operation since 1999. The ISAC east and west targets use proton beam from the cyclotron to produce various radioactive isotopes, which are then ionized and extracted. The ions are then passed through the mass separator and selected ions are transferred to the low energy experiments or injected into a radio frequency quadrupole accelerator. The accompanying radioactive contamination from the production of radioactive ions requires a complex vacuum system. The main target vacuum space consists of two semiseparate (primary and secondary) volumes pumped by turbo-molecular pumps. The primary volume uses four pumps while the secondary volume uses two pumps. Two hermetic rotary vane pumps are used as backing pumps. The nominal vacuum in both volumes is about 1.33x10{sup -4} Pa (1.0x10{sup -6} Torr). The pressure is monitored by two cold cathode and two hot filament ion gauges. The cold cathode gauges are used to interlock the system, which is critical during the bake out of the target and beam production. The exhaust gas from the vacuum pumps can be radioactive. Three gas storage tanks (decay tanks) are used for temporary storage of the radioactive exhaust and its controlled release to the atmosphere. Gas-species insensitive membrane gauges are used for monitoring the pressure in the storage tanks. This article describes the details of the ISAC target vacuum system as well as some procedures related to the handling of the exhaust gas with traces of radioactive contamination produced by the targets.

  10. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    . A battery of in vitro assays readily distinguishes between DNA intercalation, DNA groove binding-targeting drugs for cancer and beyond, the further discovery and characterization of such compounds are of considerable interest. This review outlines diagnostic experiments useful in characterizing noncovalent drug

  11. Targeting Cancer More Effectively CR@B brings together researchers from across the University and the Royal United Hospital, Bath.

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    Targeting Cancer More Effectively CR@B brings together researchers from across the University to find a cure for various types of cancer. 40 academic groups from nearly every department to bedside and back again. Drug Discovery The discovery of a new family of anti-cancer drugs called steroid

  12. Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance

    E-Print Network [OSTI]

    Wu, Alan HB

    2011-01-01T23:59:59.000Z

    this article as: Wu: Drug metabolizing enzyme activitiesgenetic variances for drug of clinical pharmacogenomicPROTEOMICS Open Access Drug metabolizing enzyme activities

  13. Targeting nanodisks via a single chain variable antibody - Apolipoprotein chimera

    SciTech Connect (OSTI)

    Iovannisci, David M.; Beckstead, Jennifer A. [Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609 (United States); Ryan, Robert O. [Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609 (United States)], E-mail: rryan@chori.org

    2009-02-06T23:59:59.000Z

    Nanodisks (ND) are nanometer scale complexes of phospholipid and apolipoprotein that have been shown to function as drug delivery vehicles. ND harboring significant quantities of the antifungal agent, amphotericin B, or the bioactive isoprenoid, all trans retinoic acid, have been generated and characterized. As currently formulated, ND possess limited targeting capability. In this study, we constructed a single chain variable antibody (scFv).apolipoprotein chimera and assessed the ability of this fusion protein to form ND and recognize the antigen to which the scFv is directed. Data obtained revealed that {alpha}-vimentin scFv.apolipoprotein A-I is functional in ND formation and antigen recognition, opening the door to the use of such chimeras in targeting drug-enriched ND to specific tissues.

  14. Drug delivery by organ-specific immunoliposomes

    SciTech Connect (OSTI)

    Maruyama, Kazuo; Mori, Atsuhide; Hunag, Leaf (Tennessee Univ., Knoxville, TN (USA). Dept. of Biochemistry); Kennel, S.J. (Oak Ridge National Lab., TN (USA))

    1990-01-01T23:59:59.000Z

    Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside GM{sub 1} to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed. 25 refs., 5 figs.

  15. Phase-remapping attack in practical quantum-key-distribution systems

    SciTech Connect (OSTI)

    Fung, Chi-Hang Fred; Qi, Bing; Lo, Hoi-Kwong [Center for Quantum Information and Quantum Control, Department of Electrical and Computer Engineering and Department of Physics, University of Toronto, Toronto, Ontario (Canada); Tamaki, Kiyoshi [NTT Basic Research Laboratories, NTT Corporation, 3-1, Morinosato Wakamiya Atsugi-Shi, Kanagawa 243-0198, Japan and CREST, JST Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012 (Japan)

    2007-03-15T23:59:59.000Z

    Quantum key distribution (QKD) can be used to generate secret keys between two distant parties. Even though QKD has been proven unconditionally secure against eavesdroppers with unlimited computation power, practical implementations of QKD may contain loopholes that may lead to the generated secret keys being compromised. In this paper, we propose a phase-remapping attack targeting two practical bidirectional QKD systems (the 'plug-and-play' system and the Sagnac system). We showed that if the users of the systems are unaware of our attack, the final key shared between them can be compromised in some situations. Specifically, we showed that, in the case of the Bennett-Brassard 1984 (BB84) protocol with ideal single-photon sources, when the quantum bit error rate (QBER) is between 14.6% and 20%, our attack renders the final key insecure, whereas the same range of QBER values has been proved secure if the two users are unaware of our attack; also, we demonstrated three situations with realistic devices where positive key rates are obtained without the consideration of Trojan horse attacks but in fact no key can be distilled. We remark that our attack is feasible with only current technology. Therefore, it is very important to be aware of our attack in order to ensure absolute security. In finding our attack, we minimize the QBER over individual measurements described by a general POVM, which has some similarity with the standard quantum state discrimination problem.

  16. Quantum key distribution with finite resources: Secret key rates via Renyi entropies

    SciTech Connect (OSTI)

    Abruzzo, Silvestre; Kampermann, Hermann; Mertz, Markus; Bruss, Dagmar [Institute for Theoretical Physics III, Heinrich-Heine-universitaet Duesseldorf, D-40225 Duesseldorf (Germany)

    2011-09-15T23:59:59.000Z

    A realistic quantum key distribution (QKD) protocol necessarily deals with finite resources, such as the number of signals exchanged by the two parties. We derive a bound on the secret key rate which is expressed as an optimization problem over Renyi entropies. Under the assumption of collective attacks by an eavesdropper, a computable estimate of our bound for the six-state protocol is provided. This bound leads to improved key rates in comparison to previous results.

  17. Reference-frame-independent quantum key distribution

    SciTech Connect (OSTI)

    Laing, Anthony; Rarity, John G.; O'Brien, Jeremy L. [Centre for Quantum Photonics, H. H. Wills Physics Laboratory and Department of Electrical and Electronic Engineering, University of Bristol, BS8 1UB (United Kingdom); Scarani, Valerio [Centre for Quantum Technologies and Department of Physics, National University of Singapore (Singapore)

    2010-07-15T23:59:59.000Z

    We describe a quantum key distribution protocol based on pairs of entangled qubits that generates a secure key between two partners in an environment of unknown and slowly varying reference frame. A direction of particle delivery is required, but the phases between the computational basis states need not be known or fixed. The protocol can simplify the operation of existing setups and has immediate applications to emerging scenarios such as earth-to-satellite links and the use of integrated photonic waveguides. We compute the asymptotic secret key rate for a two-qubit source, which coincides with the rate of the six-state protocol for white noise. We give the generalization of the protocol to higher-dimensional systems and detail a scheme for physical implementation in the three-dimensional qutrit case.

  18. Public key infrastructure for DOE security research

    SciTech Connect (OSTI)

    Aiken, R.; Foster, I.; Johnston, W.E. [and others

    1997-06-01T23:59:59.000Z

    This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

  19. Quantum repeaters and quantum key distribution: the impact of entanglement distillation on the secret key rate

    E-Print Network [OSTI]

    Sylvia Bratzik; Silvestre Abruzzo; Hermann Kampermann; Dagmar Bruß

    2013-03-14T23:59:59.000Z

    We investigate quantum repeaters in the context of quantum key distribution. We optimize the secret key rate per memory per second with respect to different distillation protocols and distillation strategies. For this purpose, we also derive an analytical expression for the average number of entangled pairs created by the quantum repeater, including classical communication times for entanglement swapping and entanglement distillation. We investigate the impact of this classical communication time on the secret key rate. We finally study the effect of the detector efficiency on the secret key rate.

  20. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01T23:59:59.000Z

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  1. On the Security of Public Key Protocols

    E-Print Network [OSTI]

    Danny Dolev; et al.

    1983-01-01T23:59:59.000Z

    Recently the use of public key encryption to provide secure network communication has received considerable attention. Such public key systems are usually effective against passive eavesdroppers, who merely tap the lines and try to decipher the message. It has been pointed out, however, that an improperly designed protocol could be vulnerable to an active saboteur, one who may impersonate another user or alter the message being transmitted. Several models are formulated in which the security of protocols can be discussed precisely. Algorithms and characteri-zations that can be used to determine protocol security in these models are given.

  2. Key Renewable Energy Opportunities for Oklahoma Tribes

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment ofLetter Report: I11IG002RTC3WASTE-TO-ENERGY:KenKeriKey IssuesKEY

  3. antirheumatic drugs dmards: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  4. antineoplastic drugs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  5. antineoplastic drugs chimio-radiotherapie: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  6. Somatic mutations in PI3K[alpha]: Structural basis for enzyme activation and drug design

    SciTech Connect (OSTI)

    Gabelli, Sandra B.; Mandelker, Diana; Schmidt-Kittler, Oleg; Vogelstein, Bert; Amzel, L. Mario (JHU); (HHMI)

    2011-09-06T23:59:59.000Z

    The PI3K pathway is a communication hub coordinating critical cell functions including cell survival, cell growth, proliferation, motility and metabolism. Because PI3K{alpha} harbors recurrent somatic mutations resulting in gains of function in human cancers, it has emerged as an important drug target for many types of solid tumors. Various PI3K isoforms are also being evaluated as potential therapeutic targets for inflammation, heart disease, and hematological malignancies. Structural biology is providing insights into the flexibility of the PI3Ks, and providing basis for understanding the effects of mutations, drug resistance and specificity.

  7. Somatic Mutations in PI3Kalpha: Structural Basis for Enzyme Activation and Drug Design

    SciTech Connect (OSTI)

    S Gabelli; D Mandelker; O Schmidt-Kittler; B Vogelstein; L Amzel

    2011-12-31T23:59:59.000Z

    The PI3K pathway is a communication hub coordinating critical cell functions including cell survival, cell growth, proliferation, motility and metabolism. Because PI3K{alpha} harbors recurrent somatic mutations resulting in gains of function in human cancers, it has emerged as an important drug target for many types of solid tumors. Various PI3K isoforms are also being evaluated as potential therapeutic targets for inflammation, heart disease, and hematological malignancies. Structural biology is providing insights into the flexibility of the PI3Ks, and providing basis for understanding the effects of mutations, drug resistance and specificity.

  8. An efficient public key infrastructure revocation mechanism

    E-Print Network [OSTI]

    Collins, Tamara Lyn

    2000-01-01T23:59:59.000Z

    IMPLEMENTATION 35 PKI Structure Key/Certificate Storage in the Repository. PKI User Interface Communication Between Entities. User Interface to RA Communication . . RA to CA Communication CA to Repository Communication. User Interface to Repository... Communication. . . . 42 11 CA to Certificate Repository Communication. . . 43 12 User Interface to Certificate Repository Communication. . . . . . . 44 13 Certificate Creation Process. . . 46 14 Certificate Revocation Process. . 48 15 Certificate Retrieval...

  9. 2 Key Achievements 7 Greenhouse Gas Reduction

    E-Print Network [OSTI]

    Princeton University Reports Contents 2 Key Achievements 7 Greenhouse Gas Reduction Campus Energy was established in 2008, the University has invested $5.3 million in energy-savings projects, resulting in annual of a 5.2-megawatt solar collector field. · Audit the remaining 20 of the top 50 energy- consuming

  10. Roadmap for selected key measurements of LHCb

    E-Print Network [OSTI]

    The LHCb Collaboration; B. Adeva; M. Adinolfi; A. Affolder; Z. Ajaltouni; J. Albrecht; F. Alessio; M. Alexander; P. Alvarez Cartelle; A. A. Alves Jr; S. Amato; Y. Amhis; J. Amoraal; J. Anderson; O. Aquines Gutierrez; L. Arrabito; M. Artuso; E. Aslanides; G. Auriemma; S. Bachmann; Y. Bagaturia; D. S. Bailey; V. Balagura; W. Baldini; MdC. Barandela Pazos; R. J. Barlow; S. Barsuk; A. Bates; C. Bauer; Th. Bauer; A. Bay; I. Bediaga; K. Belous; I. Belyaev; M. Benayoun; G. Bencivenni; R. Bernet; M. -O. Bettler; A. Bizzeti; T. Blake; F. Blanc; C. Blanks; J. Blouw; S. Blusk; A. Bobrov; V. Bocci; A. Bondar; N. Bondar; W. Bonivento; S. Borghi; A. Borgia; E. Bos; T. J. V. Bowcock; C. Bozzi; J. Bressieux; S. Brisbane; M. Britsch; N. H. Brook; H. Brown; A. Büchler-Germann; J. Buytaert; J. -P. Cachemiche; S. Cadeddu; J. M. Caicedo Carvajal; O. Callot; M. Calvi; M. Calvo Gomez; A. Camboni; W. Cameron; P. Campana; A. Carbone; G. Carboni; A. Cardini; L. Carson; K. Carvalho Akiba; G. Casse; M. Cattaneo; M. Charles; Ph. Charpentier; A. Chlopik; P. Ciambrone; X. Cid Vidal; P. J. Clark; P. E. L. Clarke; M. Clemencic; H. V. Cliff; J. Closier; C. Coca; V. Coco; J. Cogan; P. Collins; F. Constantin; G. Conti; A. Contu; G. Corti; G. A. Cowan; B. D'Almagne; C. D'Ambrosio; D. G. d'Enterria; W. Da Silva; P. David; I. De Bonis; S. De Capua; M. De Cian; F. De Lorenzi; J. M. De Miranda; L. De Paula; P. De Simone; H. De Vries; D. Decamp; H. Degaudenzi; M. Deissenroth; L. Del Buono; C. Deplano; O. Deschamps; F. Dettori; J. Dickens; H. Dijkstra; M. Dima; S. Donleavy; A. C. dos Reis; A. Dovbnya; T. Du Pree; P. -Y. Duval; L. Dwyer; R. Dzhelyadin; C. Eames; S. Easo; U. Egede; V. Egorychev; F. Eisele; S. Eisenhardt; L. Eklund; D. Esperante Pereira; L. Estève; S. Eydelman; E. Fanchini; C. Färber; G. Fardell; C. Farinelli; S. Farry; V. Fave; V. Fernandez Albor; M. Ferro-Luzzi; S. Filippov; C. Fitzpatrick; F. Fontanelli; R. Forty; M. Frank; C. Frei; M. Frosini; J. L. Fungueirino Pazos; S. Furcas; A. Gallas Torreira; D. Galli; M. Gandelman; Y. Gao; J-C. Garnier; L. Garrido; C. Gaspar; N. Gauvin; M. Gersabeck; T. Gershon; Ph. Ghez; V. Gibson; Yu. Gilitsky; V. V. Gligorov; C. Göbel; D. Golubkov; A. Golutvin; A. Gomes; M. Grabalosa Gándara; R. Graciani Diaz; L. A. Granado Cardoso; E. Graugés; G. Graziani; A. Grecu; G. Guerrer; E. Gushchin; Yu. Guz; Z. Guzik; T. Gys; F. Hachon; G. Haefeli; S. C. Haines; T. Hampson; S. Hansmann-Menzemer; R. Harji; N. Harnew; P. F. Harrison; J. He; K. Hennessy; P. Henrard; J. A. Hernando Morata; A. Hicheur; E. Hicks; W. Hofmann; K. Holubyev; P. Hopchev; W. Hulsbergen; P. Hunt; T. Huse; R. S. Huston; D. Hutchcroft; V. Iakovenko; C. Iglesias Escudero; J. Imong; R. Jacobsson; M. Jahjah Hussein; E. Jans; F. Jansen; P. Jaton; B. Jean-Marie; M. John; C. R. Jones; B. Jost; F. Kapusta; T. M. Karbach; J. Keaveney; U. Kerzel; T. Ketel; A. Keune; S. Khalil; B. Khanji; Y. M. Kim; M. Knecht; J. Knopf; S. Koblitz; A. Konoplyannikov; P. Koppenburg; I. Korolko; A. Kozlinskiy; M. Krasowski; L. Kravchuk; P. Krokovny; K. Kruzelecki; M. Kucharczyk; I. Kudryashov; T. Kvaratskheliya; D. Lacarrere; A. Lai; R. W. Lambert; G. Lanfranchi; C. Langenbruch; T. Latham; R. Le Gac; R. Lefevre; A. Leflat; J. Lefrançois; O. Leroy; K. Lessnoff; L. Li; Y. Y. Li; J. Libby; M. Lieng; R. Lindner; S. Lindsey; C. Linn; B. Liu; G. Liu; J. H. Lopes; E. Lopez Asamar; J. Luisier; F. Machefert; I. Machikhiliyan; F. Maciuc; O. Maev; J. Magnin; A. Maier; R. M. D. Mamunur; G. Manca; G. Mancinelli; N. Mangiafave; U. Marconi; F. Marin; J. Marks; G. Martellotti; A. Martens; L. Martin; D. Martinez Santos; Z. Mathe; C. Matteuzzi; V. Matveev; A. Mazurov; G. McGregor; B. Mcharek; C. Mclean; R. McNulty; M. Merk; J. Merkel; M. Merkin; R. Messi; F. C. D. Metlica; J. Michalowski; S. Miglioranzi; M. -N. Minard; S. Monteil; D. Moran; J. V. Morris; R. Mountain; I. Mous; F. Muheim; R. Muresan; F. Murtas; B. Muryn; M. Musy; J. Mylroie-Smith; P. Naik; T. Nakada; R. Nandakumar; J. Nardulli; Z. Natkaniec; M. Nedos; M. Needham; N. Neufeld; L. Nicolas; S. Nies; V. Niess; N. Nikitin; A. Noor; A. Oblakowska-Mucha; V. Obraztsov; S. Oggero; O. Okhrimenko; R. Oldeman; M. Orlandea; A. Ostankov; J. Palacios; M. Palutan; J. Panman; A. Papadelis; A. Papanestis; M. Pappagallo; C. Parkes; G. Passaleva; G. D. Patel; M. Patel; S. K. Paterson; G. N. Patrick; E. Pauna; C. Pauna; C. Pavel; A. Pazos Alvarez; A. Pellegrino; G. Penso; M. Pepe Altarelli; S. Perazzini; D. L. Perego; A. Pérez-Calero Yzquierdo; E. Perez Trigo; P. Perret; G. Pessina; A. Petrella; A. Petrolini; B. Pietrzyk; D. Pinci; S. Playfer; M. Plo Casasus; G. Polok; A. Poluektov; E. Polycarpo; D. Popov; B. Popovici; S. Poss; C. Potterat; A. Powell; S. Pozzi; V. Pugatch; A. Puig Navarro; W. Qian; J. H. Rademacker; B. Rakotomiaramanana; I. Raniuk; G. Raven; S. Redford; W. Reece

    2010-11-23T23:59:59.000Z

    Six of the key physics measurements that will be made by the LHCb experiment, concerning CP asymmetries and rare B decays, are discussed in detail. The "road map" towards the precision measurements is presented, including the use of control channels and other techniques to understand the performance of the detector with the first data from the LHC.

  11. Key Management Challenges in Smart Grid

    SciTech Connect (OSTI)

    Sheldon, Frederick T [ORNL] [ORNL; Duren, Mike [Sypris Electronics, LLC] [Sypris Electronics, LLC

    2012-01-01T23:59:59.000Z

    Agenda Awarded in February 2011 Team of industry and research organizations Project Objectives Address difficult issues Complexity Diversity of systems Scale Longevity of solution Participate in standards efforts and working groups Develop innovative key management solutions Modeling and simulation ORNL Cyber Security Econometric Enterprise System Demonstrate effectiveness of solution Demonstrate scalability

  12. CHEMICAL ABBREVIATION KEY ABBREVIATION CHEMICAL NAME HAZARDS

    E-Print Network [OSTI]

    Pawlowski, Wojtek

    Corrosive - base LiCl Lithium chloride Harmful MeOH Methanol Flammable #12;CHEMICAL ABBREVIATION KEY Irritant destain Methanol,acetic acid,H2O Flammable, Corrosive - acid DI H2O Deionized water DCM FeCl3 Iron(III) chloride Corrosive - acid FeSO4 Iron(II) sulfate Toxic H2O Water HCl Hydrochloric

  13. BACK TO BASICS: YOUR KEYS TO SAFE

    E-Print Network [OSTI]

    Kirschner, Denise

    BACK TO BASICS: YOUR KEYS TO SAFE DRIVING BUCKLE UP! Seat belts should never have time off DRIVE the back seat to the front seat.4 ·The back is the best place for pets. According to AAA, similar. Never place the shoulder portion under your arm or behind your back! ·Drivers should sit with at least

  14. Rangeland ecology: Key global research issues & questions

    E-Print Network [OSTI]

    1 Rangeland ecology: Key global research issues & questions Robin Reid and Maria Fernandez-Gimenez This paper discusses developments in our understanding about rangeland ecology and rangeland dynamics in the last 20 years. Before the late 1980's, the mainstream view in range ecology was that livestock

  15. Rangeland ecology: Key global research issues & questions

    E-Print Network [OSTI]

    1 Rangeland ecology: Key global research issues & questions Robin Reid1 and Maria Fernandez Ecology Lab 2Associate Professor Colorado State University, Fort Collins, Colorado, USA Global Issues and Questions in Rangeland Ecology · Despite the focus here on global issues, we need to recognize that Mongolia

  16. Key facts about Argonne National Laboratory

    E-Print Network [OSTI]

    Kemner, Ken

    Key facts about Argonne National Laboratory Argonne National Laboratory occupies 1,500 wooded acres in southeast DuPage County near Chicago. Mission Argonne's mission is to apply a unique blend of world needs of our nation. Argonne conducts R&D in many areas of basic and applied science and engineering

  17. www.defra.gov.uk Environmental Key

    E-Print Network [OSTI]

    ;Environmental Key Performance Indicators Reporting Guidelines for UK Business #12;Department for Environment with the Crown. This publication (excluding the logo) may be reproduced free of charge in any format or medium they operate in, and their impact on the environment, are most likely to prosper in the long-term. At the same

  18. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release is controlled by polymer degradation

  19. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    1 Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable The biodegradable polymer such as poly(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release

  20. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01T23:59:59.000Z

    2006. “The Market for Illegal Goods: The Case of Drugs. ”Informing America’s Policy on Illegal Drugs: What We Don’tViewpoints. Should Illegal Drugs Be Decriminalized? ” In

  1. Prototype Spallation Neutron Source Rotating Target Assembly Final Test Report

    SciTech Connect (OSTI)

    McManamy, Thomas J [ORNL; Graves, Van [Oak Ridge National Laboratory (ORNL); Garmendia, Amaia Zarraoa [IDOM Bilbao; Sorda, Fernando [ESS Bilbao; Etxeita, Borja [IDOM Bilbao; Rennich, Mark J [ORNL

    2011-01-01T23:59:59.000Z

    A full-scale prototype of an extended vertical shaft, rotating target assembly based on a conceptual target design for a 1 to 3-MW spallation facility was built and tested. Key elements of the drive/coupling assembly implemented in the prototype include high integrity dynamic face seals, commercially available bearings, realistic manufacturing tolerances, effective monitoring and controls, and fail-safe shutdown features. A representative target disk suspended on a 3.5 meter prototypical shaft was coupled with the drive to complete the mechanical tests. Successful operation for 5400 hours confirmed the overall mechanical feasibility of the extended vertical shaft rotating target concept. The prototype system showed no indications of performance deterioration and the equipment did not require maintenance or relubrication.

  2. Target: Subpoena (2010-SE-2001)

    Broader source: Energy.gov [DOE]

    DOE issued a Subpoena for Information and Production of Documents to Target Corporation requesting information regarding the compliance of various torchieres Target has distributed in commerce in the U.S.

  3. Non-PGM Target Update

    Broader source: Energy.gov (indexed) [DOE]

    targets that need to be met are cost, efficiency, and durability. A secondary target is heat rejection at rated power. (ANL) * Given that for current Pt systems catalyst cost is ...

  4. Chemical and Petroleum Engineering Key and Lab Space Agreement

    E-Print Network [OSTI]

    Calgary, University of

    Chemical and Petroleum Engineering Key and Lab Space Agreement Key Holder Information Last Name and Petroleum Engineering remain the property of the Department. I agree to pay a deposit for the keys/Graduate Student Study space that has been assigned. Keys Any keys issued to me from the Department of Chemical

  5. Target | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries PvtStratosolar Jump to:Holdings Co08.0Information ExpansionTarget GmbH Jump

  6. Cancer Cell Targeting Androgen Receptor

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    in the development of endo- crine therapies targeting estrogen production or ER for both breast cancer treatment targeting of AR, Wnt or HER2 signaling impairs androgen-stimulated tumor cell growth suggesting potential. Therapies targeting HER2 such as trastuzumab are becoming increasingly important in the treatment of HER2

  7. Rotating Target Development for SNS Second Target Station

    SciTech Connect (OSTI)

    McManamy, Thomas J [ORNL; Rennich, Mark J [ORNL; Crawford, Roy K [ORNL; Geoghegan, Patrick J [ORNL; Janney, Jim G [ORNL

    2010-01-01T23:59:59.000Z

    A rotating target for the second target station (STS) at SNS has been identified as an option along with a mercury target. Evaluation of the rotating target alternative for STS has started at 1.5 MW which is considered an upper bound for the power. Previous preconceptual design work for a 3 MW rotating target is being modified for the lower power level. Transient thermal analysis for a total loss of active water cooling has been done for a simplified 2D model of the target and shielding monolith which shows that peak temperatures are well below the level at which tungsten vaporization by steam could exceed site boundary dose limits. Design analysis and integration configuration studies have been done for the target-moderator-reflector assembly which maximizes the number of neutron beam lines and provides for replacement of the target and moderators. Target building hot cell arrangement for this option will be described. An option for operation in rough vacuum without a proton beam window using Ferro fluid seals on a vertical shaft is being developed. A full scale prototypic drive module based on the 3 MW preconceptual design has been fabricated and successfully tested with a shaft and mock up target supplied by the ESS-Bilbao team. Overall planning leading to decision between mercury and the rotating target in 2011 will be discussed

  8. Three key elements necessary for successful testing

    SciTech Connect (OSTI)

    Ehlig-Economides, C.A.; Hegeman, P. (Schlumberger Oilfield Services, Houston, TX (United States)); Clark, G. (Schlumberger Oilfield Services, Aberdeen (United Kingdom))

    1994-07-25T23:59:59.000Z

    Real-time surface readout during data acquisition, downhole shutting, and appropriate pressure gauges are three key elements for successful well tests. These elements are often overlooked in designing and implementing a successful well test. This second in a series of three articles on well testing shows how these elements affected the testing of an example well. Also reviewed are the capabilities of several new testing tools and techniques.

  9. Key Physical Mechanisms in Nanostructured Solar Cells

    SciTech Connect (OSTI)

    Dr Stephan Bremner

    2010-07-21T23:59:59.000Z

    The objective of the project was to study both theoretically and experimentally the excitation, recombination and transport properties required for nanostructured solar cells to deliver energy conversion efficiencies well in excess of conventional limits. These objectives were met by concentrating on three key areas, namely, investigation of physical mechanisms present in nanostructured solar cells, characterization of loss mechanisms in nanostructured solar cells and determining the properties required of nanostructured solar cells in order to achieve high efficiency and the design implications.

  10. Building America Expert Meeting: Key Innovations for Adding Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Key Innovations for Adding Energy Efficiency to Maintenance Projects Building America Expert Meeting: Key Innovations for Adding Energy Efficiency to Maintenance Projects This...

  11. authenticated key exchange: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    desirable attributes. Index Terms--Mutual Authentication; Key Management; SRP; Security; Smart Meter; Smart Leung, Victor C.M. 56 Authentication and Key Agreement via Memorable...

  12. analysis material key: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Temperature(C) 200 2 Finite key analysis for symmetric attacks in quantum key distribution Quantum Physics (arXiv) Summary: We introduce a constructive method to calculate...

  13. Cooling Towers: Understanding Key Components of Cooling Towers...

    Office of Environmental Management (EM)

    Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve Water Efficiency Cooling Towers: Understanding Key Components of Cooling Towers and How to Improve...

  14. Midstream Infrastructure Improvements Key to Realizing Full Potential...

    Office of Environmental Management (EM)

    Midstream Infrastructure Improvements Key to Realizing Full Potential of Domestic Natural Gas Midstream Infrastructure Improvements Key to Realizing Full Potential of Domestic...

  15. Target detection portal

    DOE Patents [OSTI]

    Linker, Kevin L. (Albuquerque, NM); Brusseau, Charles A. (Tijeras, NM)

    2002-01-01T23:59:59.000Z

    A portal apparatus for screening persons or objects for the presence of trace amounts of target substances such as explosives, narcotics, radioactive materials, and certain chemical materials. The portal apparatus can have a one-sided exhaust for an exhaust stream, an interior wall configuration with a concave-shape across a horizontal cross-section for each of two facing sides to result in improved airflow and reduced washout relative to a configuration with substantially flat parallel sides; air curtains to reduce washout; ionizing sprays to collect particles bound by static forces, as well as gas jet nozzles to dislodge particles bound by adhesion to the screened person or object. The portal apparatus can be included in a detection system with a preconcentrator and a detector.

  16. PDFs for nuclear targets

    E-Print Network [OSTI]

    Karol Kovarik

    2010-06-25T23:59:59.000Z

    Understanding nuclear effects in parton distribution functions (PDF) is an essential component needed to determine the strange and anti-strange quark contributions in the proton. In addition Nuclear Parton Distribution Functions (NPDF) are critically important for any collider experiment with nuclei (e.g. RHIC, ALICE). Here two next-to-leading order chi^2-analyses of NPDF are presented. The first uses neutral current charged-lepton Deeply Inelastic Scattering (DIS) and Drell-Yan data for several nuclear targets and the second uses neutrino-nucleon DIS data. We compare the nuclear corrections factors (F_2^Fe/F_2^D) for the charged-lepton data with other results from the literature. In particular, we compare and contrast fits based upon the charged-lepton DIS data with those using neutrino-nucleon DIS data.

  17. DRUG STUDY QUESTIONNAIRE PROGRAM DIRECTOR:______________________________________ DATE:_____________________________

    E-Print Network [OSTI]

    Acton, Scott

    DRUG STUDY QUESTIONNAIRE PROGRAM DIRECTOR:______________________________________ DATE and/or efficacy of a drug? A. If yes, is the testing, study, evaluation or research primarily for use in pharmaceutical pre-market clearance applications to the Food and Drug Administration? 2. Is drug administered

  18. Min-entropy and quantum key distribution: Nonzero key rates for ''small'' numbers of signals

    SciTech Connect (OSTI)

    Bratzik, Sylvia; Mertz, Markus; Kampermann, Hermann; Bruss, Dagmar [Institute for Theoretical Physics III, Heinrich-Heine-Universitaet Duesseldorf, D-40225 Duesseldorf (Germany)

    2011-02-15T23:59:59.000Z

    We calculate an achievable secret key rate for quantum key distribution with a finite number of signals by evaluating the quantum conditional min-entropy explicitly. The min-entropy for a classical random variable is the negative logarithm of the maximal value in its probability distribution. The quantum conditional min-entropy can be expressed in terms of the guessing probability, which we calculate for d-dimensional systems. We compare these key rates to previous approaches using the von Neumann entropy and find nonzero key rates for a smaller number of signals. Furthermore, we improve the secret key rates by modifying the parameter estimation step. Both improvements taken together lead to nonzero key rates for only 10{sup 4}-10{sup 5} signals. An interesting conclusion can also be drawn from the additivity of the min-entropy and its relation to the guessing probability: for a set of symmetric tensor product states, the optimal minimum-error discrimination (MED) measurement is the optimal MED measurement on each subsystem.

  19. Seismic technology will be of key importance for evaluat-ing gas-hydrate resources, particularly across the Gulf of

    E-Print Network [OSTI]

    Texas at Austin, University of

    Seismic technology will be of key importance for evaluat- ing gas-hydrate resources, particularly to be acquired. To apply seismic technology to gas-hydrate studies in the gulf in an optimal manner, it is essential to understand the seismic target that has to be analyzed. What is gas hydrate? Gas hydrate

  20. Quantum key distribution with entangled photon sources

    E-Print Network [OSTI]

    Xiongfeng Ma; Chi-Hang Fred Fung; Hoi-Kwong Lo

    2007-03-14T23:59:59.000Z

    A parametric down-conversion (PDC) source can be used as either a triggered single photon source or an entangled photon source in quantum key distribution (QKD). The triggering PDC QKD has already been studied in the literature. On the other hand, a model and a post-processing protocol for the entanglement PDC QKD are still missing. In this paper, we fill in this important gap by proposing such a model and a post-processing protocol for the entanglement PDC QKD. Although the PDC model is proposed to study the entanglement-based QKD, we emphasize that our generic model may also be useful for other non-QKD experiments involving a PDC source. Since an entangled PDC source is a basis independent source, we apply Koashi-Preskill's security analysis to the entanglement PDC QKD. We also investigate the entanglement PDC QKD with two-way classical communications. We find that the recurrence scheme increases the key rate and Gottesman-Lo protocol helps tolerate higher channel losses. By simulating a recent 144km open-air PDC experiment, we compare three implementations -- entanglement PDC QKD, triggering PDC QKD and coherent state QKD. The simulation result suggests that the entanglement PDC QKD can tolerate higher channel losses than the coherent state QKD. The coherent state QKD with decoy states is able to achieve highest key rate in the low and medium-loss regions. By applying Gottesman-Lo two-way post-processing protocol, the entanglement PDC QKD can tolerate up to 70dB combined channel losses (35dB for each channel) provided that the PDC source is placed in between Alice and Bob. After considering statistical fluctuations, the PDC setup can tolerate up to 53dB channel losses.

  1. STGWG Key Outcomes for May 3, 2010

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSARDevelopmental AssignmentApril 2,OCTOBER 2-3,|Key

  2. STGWG Key Outcomes for October 21, 2009

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSARDevelopmental AssignmentApril 2,OCTOBER 2-3,|Key

  3. Key Associados Bradesco JV | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluatingGroup |Jilin Zhongdiantou New EnergyKenosistec SrlKenyonKetchikan PublicKey

  4. Bioenergy Key Publications | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube platform isEnergyMeeting | Department ofTransportation Fuels | DepartmentKey

  5. Evotec has teamed up with the Harwell Imaging Partnership (HIP) to maximise the potential of their research into cancer treatment drugs

    E-Print Network [OSTI]

    Zharkova, Valentina V.

    of their research into cancer treatment drugs using the Science and Technology Facilities Council (STFC)'s Central-based cancer treatments work by inhibiting the signals that cause mutated cancer cells to divide and multiply to the treatment. The ability to conduct single-cell imaging of inhibitor drugs binding their target in cancer

  6. Key Predistribution Techniques for Grid-Based Wireless Sensor Networks

    E-Print Network [OSTI]

    Key Predistribution Techniques for Grid-Based Wireless Sensor Networks Simon R. Blackburn1 , Tuvi sensor networks. Networks consisting of wireless sensor nodes ar- ranged in a grid pattern have many for the instantiation of these schemes. Key words: Key predistribution, wireless sensor networks; symmetric key

  7. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, Douglas N. (Knoxville, TN)

    1996-01-01T23:59:59.000Z

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

  8. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, D.N.

    1996-01-09T23:59:59.000Z

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

  9. HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS

    E-Print Network [OSTI]

    Kim, Duck O.

    containers, pickup hazardous drug waste and provide chemo spill kits to appropriate areas. The OfficeHAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC AND OTHER HAZARDOUS DRUGS, administration and disposal of drug residues. Drugs are classified as hazardous if studies in animals and

  10. Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates to paclitaxel and the subsequent ring-opening polymerization of lactide. The drug-initiated, controlled(-caprolactone)) was also achieved through drug/(BDI-II)ZnN(TMS)2-mediated controlled polymerization. These drug

  11. ForPeerReview Drug user dynamics: a compartmental model of drug users

    E-Print Network [OSTI]

    Triolo, Livio

    ForPeerReview Only Drug user dynamics: a compartmental model of drug users for scenario analyses Journal: Drugs: Education, Prevention & Policy Manuscript ID: CDEP-2012-0094.R1 Manuscript Type: Original papers Keywords: Drug use, Epidemics, Compartmental modeling, Scenario analysis, Evaluation, Drug policy

  12. Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug-

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug- Poly(Ocarboxyanhydride) Nanoconjugates Qian Yin, Rong Tong,, Yunxiang Xu, Kwanghyun Baek of polymer-drug conjugates for nanoparticulate drug delivery: hydroxyl-containing drug (e.g., camptothecin

  13. Target Space Duality III: Potentials

    E-Print Network [OSTI]

    Orlando Alvarez; Blazej Ruszczycki

    2007-12-31T23:59:59.000Z

    We generalize previous results on target space duality to the case where there are background fields and the sigma model lagrangian has a potential function.

  14. Quantum key distribution with entangled photon sources

    E-Print Network [OSTI]

    Ma, X; Lo, H K; Ma, Xiongfeng; Fung, Chi-Hang Fred; Lo, Hoi-Kwong

    2007-01-01T23:59:59.000Z

    A parametric down-conversion (PDC) source can be used as either a triggered single photon source or an entangled photon source in quantum key distribution (QKD). The triggering PDC QKD has already been studied in the literature. On the other hand, a model and a post-processing protocol for the entanglement PDC QKD are still missing. In this paper, we fill in this important gap by proposing such a model and a post-processing protocol for the entanglement PDC QKD. Although the PDC model is proposed to study the entanglement-based QKD, we emphasize that our generic model may also be useful for other non-QKD experiments involving a PDC source. Since an entangled PDC source is a basis independent source, we apply Koashi-Preskill's security analysis to the entanglement PDC QKD. We also investigate the entanglement PDC QKD with two-way classical communications. We find that the recurrence scheme increases the key rate and Gottesman-Lo protocol helps tolerate higher channel losses. By simulating a recent 144km open-a...

  15. Realizing Technologies for Magnetized Target Fusion

    SciTech Connect (OSTI)

    Wurden, Glen A. [Los Alamos National Laboratory

    2012-08-24T23:59:59.000Z

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  16. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  17. Drug Trafficking Organizations and Counter-Drug Strategies in the U.S.-Mexican Context

    E-Print Network [OSTI]

    Astorga, Luis; Shirk, David A.

    2010-01-01T23:59:59.000Z

    Analytic Assessment of U.S. Drug Policy. Washington, D.C. ,K. (2008). Mexico Faces New Drug Challenge: Mini-Submarines.Mayors on Front Line of the Drug War. Los Angeles Times Los

  18. One-way quantum key distribution: Simple upper bound on the secret key rate

    SciTech Connect (OSTI)

    Moroder, Tobias; Luetkenhaus, Norbert [Institute of Theoretical Physics I and Max-Planck Research Group, Institute of Optics, Information and Photonics, University Erlangen-Nuremberg, Staudtstrasse 7, 91058 Erlangen (Germany); Institute for Quantum Computing, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1 (Canada); Curty, Marcos [Institute of Theoretical Physics I and Max-Planck Research Group, Institute of Optics, Information and Photonics, University Erlangen-Nuremberg, Staudtstrasse 7, 91058 Erlangen (Germany)

    2006-11-15T23:59:59.000Z

    We present a simple method to obtain an upper bound on the achievable secret key rate in quantum key distribution (QKD) protocols that use only unidirectional classical communication during the public-discussion phase. This method is based on a necessary precondition for one-way secret key distillation; the legitimate users need to prove that there exists no quantum state having a symmetric extension that is compatible with the available measurements results. The main advantage of the obtained upper bound is that it can be formulated as a semidefinite program, which can be efficiently solved. We illustrate our results by analyzing two well-known qubit-based QKD protocols: the four-state protocol and the six-state protocol.

  19. Target Proposal Feb. 15, 2000

    E-Print Network [OSTI]

    McDonald, Kirk

    enables simpler system design, compatible with high magnetic field, no toxic waste, replaceable option initial approach can be very important in progress toward a real facility #12; Target Proposal Feb. 15 Target Survivability (cont) . Cooling ­ 23 kW per MW of beam power -- A significant advantage of carbon

  20. VERTEX CHAMBERS TARGET CELL CALORIMETER

    E-Print Network [OSTI]

    DRIFT VC 1/2 FC 1/2 VERTEX CHAMBERS TARGET CELL DVC MC 1­3 HODOSCOPE H0 MONITOR BC 1/2 BC 3/4 TRD at Threashold Lambda Physics (u ­L spin transfer) Motivation: ­ W L Target cell e beam L p p e ­ Elastic: Peltier elements ( T ~ ­20C ) ­ Custom built electronics + HELIX chips low autgassing (

  1. Magnetized Target Fusion Collaboration. Final report

    SciTech Connect (OSTI)

    John Slough

    2012-04-18T23:59:59.000Z

    Nuclear fusion has the potential to satisfy the prodigious power that the world will demand in the future, but it has yet to be harnessed as a practical energy source. The entry of fusion as a viable, competitive source of power has been stymied by the challenge of finding an economical way to provide for the confinement and heating of the plasma fuel. It is the contention here that a simpler path to fusion can be achieved by creating fusion conditions in a different regime at small scale (~ a few cm). One such program now under study, referred to as Magnetized Target Fusion (MTF), is directed at obtaining fusion in this high energy density regime by rapidly compressing a compact toroidal plasmoid commonly referred to as a Field Reversed Configuration (FRC). To make fusion practical at this smaller scale, an efficient method for compressing the FRC to fusion gain conditions is required. In one variant of MTF a conducting metal shell is imploded electrically. This radially compresses and heats the FRC plasmoid to fusion conditions. The closed magnetic field in the target plasmoid suppresses the thermal transport to the confining shell, thus lowering the imploding power needed to compress the target. The undertaking described in this report was to provide a suitable target FRC, as well as a simple and robust method for inserting and stopping the FRC within the imploding liner. The FRC must also survive during the time it takes for the metal liner to compress the FRC target. The initial work at the UW was focused on developing adequate preionization and flux trapping that were found to be essential in past experiments for obtaining the density, flux and most critically, FRC lifetime required for MTF. The timescale for testing and development of such a source can be rapidly accelerated by taking advantage of a new facility funded by the Department of Energy. At this facility, two inductive plasma accelerators (IPA) were constructed and tested. Recent experiments with these IPAs have demonstrated the ability to rapidly form, accelerate and merge two hypervelocity FRCs into a compression chamber. The resultant FRC that was formed was hot (T{sub ion} ~ 400 eV), stationary, and stable with a configuration lifetime several times that necessary for the MTF liner experiments. The accelerator length was less than 1 meter, and the time from the initiation of formation to the establishment of the final equilibrium was less than 10 microseconds. With some modification, each accelerator can be made capable of producing FRCs suitable for the production of the target plasma for the MTF liner experiment. Based on the initial FRC merging/compression results, the design and methodology for an experimental realization of the target plasma for the MTF liner experiment can now be defined. The construction and testing of the key components for the formation of the target plasma at the Air Force Research Laboratory (AFRL) will be performed on the IPA experiment, now at MSNW. A high density FRC plasmoid will be formed and accelerated out of each IPA into a merging/compression chamber similar to the imploding liner at AFRL. The properties of the resultant FRC plasma (size, temperature, density, flux, lifetime) will be obtained. The process will be optimized, and a final design for implementation at AFRL will be carried out. When implemented at AFRL it is anticipated that the colliding/merging FRCs will then be compressed by the liner. In this manner it is hoped that ultimately a plasma with ion temperatures reaching the 10 keV range and fusion gain near unity can be obtained.

  2. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug is the probability that the tested individual uses this illegal drug? What is the probability of a false positive

  3. Skin: Major target organ of allergic reactions to small molecular weight compounds

    SciTech Connect (OSTI)

    Merk, Hans F. [Department of Dermatology and Allergology, Univ.-Hospital, RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen (Germany)], E-mail: hans.merk@post.rwth-aachen.de; Baron, Jens M.; Neis, Mark M.; Obrigkeit, Daniela Hoeller [Department of Dermatology and Allergology, Univ.-Hospital, RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen (Germany); Karlberg, Ann-Therese [Dermatochemistry and Skin Allergy, Department of Chemistry, Goeteborg University, SE-412 96 Goeteborg (Sweden)

    2007-11-01T23:59:59.000Z

    Skin is a major target organ for allergic reactions to small molecular weight compounds. Drug allergic reactions may be life-threatening such as in the case of anaphylactic reactions or bullous drug reactions and occur in about 5% of all hospitalized patients. Allergic contact dermatitis has an enormous influence on the social life of the patient because it is the most frequent reason for occupational skin diseases and the treatment and prevention of this disease cost approximately Euro 3 billion per year in Germany. The different proposed pathophysiological pathways leading to a drug eruption are discussed in this paper. All major enzymes which are involved in the metabolism of xenobiotica were shown to be present in skin. Evidence supporting the role of metabolism in the development of drug allergy and allergic contact dermatitis is demonstrated in the example of sulphonamides and fragrances.

  4. The pipeline and future of drug development in schizophrenia

    E-Print Network [OSTI]

    Gray, J A; Roth, B L

    2007-01-01T23:59:59.000Z

    The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

  5. adverse drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  6. antiepileptic drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  7. Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

  8. Packaging for a drug delivery microelectromechanical system

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2005-01-01T23:59:59.000Z

    Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

  9. Financing drug discovery for orphan diseases

    E-Print Network [OSTI]

    Fagnan, David Erik

    Recently proposed ‘megafund’ financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term ...

  10. authenticated key agreement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    desirable attributes. Index Terms--Mutual Authentication; Key Management; SRP; Security; Smart Meter; Smart Leung, Victor C.M. 53 On the security of some password-based key...

  11. "Turn-Key" Open Source Software Solutions for Energy Management...

    Energy Savers [EERE]

    "Turn-Key" Open Source Software Solutions for Energy Management of Small to Medium Sized Buildings (DE-FOA-0000822) "Turn-Key" Open Source Software Solutions for Energy Management...

  12. Quantum Key Distribution by Utilizing Four-Level Particles

    E-Print Network [OSTI]

    Tao Yan; Fengli Yan

    2010-02-09T23:59:59.000Z

    We present a quantum key distribution protocol based on four-level particles entanglement. Furthermore, a controlled quantum key distribution protocol is proposed by utilizing three four-level particles. We show that the two protocols are secure.

  13. The impacts of urbanization on endangered florida key deer

    E-Print Network [OSTI]

    Harveson, Patricia Moody

    2006-04-12T23:59:59.000Z

    for resources between man and wildlife continues, it is important to understand the effects of urbanization on species. Endangered Key deer (Odocoileus virginianus clavium) are endemic to the Florida Keys archipelago stretching southwest off the southern tip...

  14. Exploring the context : a small hotel in Key West

    E-Print Network [OSTI]

    VanBeuzekom, Edrick

    1984-01-01T23:59:59.000Z

    This thesis develops a personal method and approach for designing in a delicate context such as the Key West Historic District. This thesis is composed of two parts. The first part presents observations of Key West, focusing ...

  15. actual key success: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    key exchange over an insecure channel. The security of the proposed algorithm grows as NPm, where M, P are the size of the key and the computational commplexity fo the linear...

  16. access technologies key: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    key exchange over an insecure channel. The security of the proposed algorithm grows as NPm, where M, P are the size of the key and the computational commplexity fo the linear...

  17. Turn Your Key, Be Idle Free | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Turn Your Key, Be Idle Free Turn Your Key, Be Idle Free April 13, 2010 - 7:30am Addthis Shannon Brescher Shea Communications Manager, Clean Cities Program What activity wastes...

  18. Low-density random matrices for secret key extraction

    E-Print Network [OSTI]

    Zhou, Hongchao

    Secret key extraction, the task of extracting a secret key from shared information that is partially known by an eavesdropper, has important applications in cryptography. Motivated by the requirements of high-speed quantum ...

  19. Secret key agreement using asymmetry in channel state knowledge

    E-Print Network [OSTI]

    Wornell, Gregory W.

    We study secret-key agreement protocols over a wiretap channel controlled by a state parameter. The secret-key capacity is established when the wiretap channel is discrete and memoryless, the sender and receiver are both ...

  20. Compression station key to Texas pipeline project

    SciTech Connect (OSTI)

    NONE

    1996-10-01T23:59:59.000Z

    This was probably the largest pipeline project in the US last year, and the largest in Texas in the last decade. The new compressor station is a key element in this project. TECO, its servicing dealer, and compression packager worked closely throughout the planning and installation stages of the project. To handle the amount of gas required, TECO selected the GEMINI F604-1 compressor, a four-throw, single-stage unit with a six-inch stroke manufactured by Weatherford Enterra Compression Co. (WECC) in Corpus Christi, TX. TECO also chose WECC to package the compressors. Responsibility for ongoing support of the units will be shared among TECO, the service dealer and the packager. TECO is sending people to be trained by WECC, and because the G3600 family of engines is still relatively new, both the Caterpillar dealer and WECC sent people for advanced training at Caterpillar facilities in Peoria, IL. As part of its service commitment to TECO, the servicing dealer drew up a detailed product support plan, encompassing these five concerns: Training, tooling; parts support; service support; and commissioning.

  1. Relationship between key events in Earth history

    E-Print Network [OSTI]

    Gillman, Michael

    2015-01-01T23:59:59.000Z

    A model of cyclical (sinusoidal) motion of the solar system, intercepting event lines distributed at fixed intervals, explains the pattern of timings of mass extinctions, earlier glaciations, largest impact craters and the largest known extrusions of magma in the history of the Earth. The model reveals links between several sets of key events, including the end-Cretaceous and end-Ordovician extinctions with the Marinoan glaciation, and the end-Permian with the end-Serpukhovian extinctions. The model is supported by significant clusters of events and a significant reduction of impact crater size with position (sine value). The pattern of event lines is sustained to the earliest-dated impact craters (2023 and 1849 Ma) and to the origin of the solar system, close to 4567.4 Ma. The implication is that, for the entirety of its existence, the solar system has passed in a consistent manner through a predictably structured galaxy. Dark matter is a possible contender for the structure determining the event lines.

  2. Residential Energy Efficiency Financing: Key Elements of Program Design

    Broader source: Energy.gov [DOE]

    Presents key programmatic elements and context of financing initiatives, including contractor support, rebates, quality assurance, and more.

  3. A Full Key Recovery Attack on HMAC-AURORA-512

    E-Print Network [OSTI]

    A Full Key Recovery Attack on HMAC-AURORA-512 Yu Sasaki NTT Information Sharing Platform.yu@lab.ntt.co.jp Abstract. In this note, we present a full key recovery attack on HMAC- AURORA-512 when 512-bit secret keys is 2259 AURORA-512 operations, which is significantly less than the complexity of the exhaustive search

  4. Why Hierarchical Key Distribution is Appropriate for Multicast Networks

    E-Print Network [OSTI]

    Zheng, Yuliang

    Why Hierarchical Key Distribution is Appropriate for Multicast Networks Chandana Gamage, Jussipekka rationale for many key distribution schemes for multicast networks are based on heuristic arguments on e of multicast group formation and network growth to look at the selection of a key distribution scheme from

  5. Secret-key generation with correlated sources and noisy channels

    E-Print Network [OSTI]

    Khisti, Ashish

    Secret-key generation with correlated sources and noisy channels Ashish Khisti EECS Dept. MIT for secret-key generation between remote terminals is considered. The sender communicates to the receiver discrete memoryless sources. Lower and upper bounds for the secret-key rate are presented and shown

  6. Interactive Secret Key Generation over Reciprocal Fading Channels

    E-Print Network [OSTI]

    Khisti, Ashish

    Interactive Secret Key Generation over Reciprocal Fading Channels Ashish Khisti Dept. of Electrical--We study a two-terminal secret-key generation problem over a two-way, approximately reciprocal, block of the secret-key is gen- erated from the correlated channel state sequences by creating omniscience between

  7. Protecting Secret Keys with Personal Entropy Carl Ellison

    E-Print Network [OSTI]

    Schneier, Bruce

    Protecting Secret Keys with Personal Entropy Carl Ellison Cybercash, Inc., cme@cybercash.com Chris technology often requires users to protect a secret key by selecting a password or passphrase. While a good to recover the secret key. As time passes, the ability to remember the passphrase fades and the user may

  8. Secret-Key Generation over Reciprocal Fading Channels

    E-Print Network [OSTI]

    Khisti, Ashish

    Secret-Key Generation over Reciprocal Fading Channels Ashish Khisti Department of Electrical and Computer Engineering University of Toronto Nov. 14, 2012 #12;Motivation Secret-Key Generation in Wireless, 2012 2/ 22 #12;Motivation Secret-Key Generation in Wireless Fading Channels A B KA KB Forward

  9. Secret-Key Generation from Channel Reciprocity: A Separation Approach

    E-Print Network [OSTI]

    Khisti, Ashish

    Secret-Key Generation from Channel Reciprocity: A Separation Approach Ashish Khisti Department: Secret-Key Generation Secure Message Transmission Physical Layer Authentication Jamming Resistance Feb 11, 2013 2/ 20 #12;Motivation Secret-Key Generation in Wireless Fading Channels A B KA KB Forward

  10. Security proof for quantum key distribution using qudit systems

    SciTech Connect (OSTI)

    Sheridan, Lana [Centre for Quantum Technologies, National University of Singapore (Singapore); Scarani, Valerio [Centre for Quantum Technologies, National University of Singapore (Singapore); Department of Physics, National University of Singapore (Singapore)

    2010-09-15T23:59:59.000Z

    We provide security bounds against coherent attacks for two families of quantum key distribution protocols that use d-dimensional quantum systems. In the asymptotic regime, both the secret key rate for fixed noise and the robustness to noise increase with d. The finite key corrections are found to be almost insensitive to d < or approx. 20.

  11. Secure Broadcasting of a Common Message with Independent Secret Keys

    E-Print Network [OSTI]

    Khisti, Ashish

    Secure Broadcasting of a Common Message with Independent Secret Keys Rafael F. Schaefer Department broadcasting with indepen- dent secret keys is studied. The particular scenario is analyzed where a common of it. The transmitter shares independent secret keys of arbitrary rates with both legitimate receivers

  12. Dynamic Key Ring Update Mechanism for Mobile Wireless Sensor Networks

    E-Print Network [OSTI]

    Yanikoglu, Berrin

    @sabanciuniv.edu Abstract--Key distribution is an important issue to provide security in Wireless Sensor Networks (WSNs. For the performance evaluation basis, we used our mechanism together with a location based key pre-distribution scheme Terms--mobile wireless sensor networks, key ring update, security, resiliency, connectivity I

  13. Drug delivery Preparation of Monodisperse Biodegradable Polymer

    E-Print Network [OSTI]

    Prentiss, Mara

    Drug delivery Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow-Focusing Device for Controlled Drug Delivery Qiaobing Xu, Michinao Hashimoto, Tram T. Dang, Todd microparticles have broad utility as vehicles for drug delivery and form the basis of several therapies approved

  14. prescription drug program highlights retail pharmacy prescriptions

    E-Print Network [OSTI]

    Scharer, John E.

    prescription drug program highlights SHIP retail pharmacy prescriptions The informedRx retail interactions and duplicate therapies. Brand name and generic drugs are included in your pharmacy benefit, but you will save the most money by selecting generic drug options when available. On myinformedRx.com you

  15. Imaging in Drug Discovery and Development

    E-Print Network [OSTI]

    Zanibbi, Richard

    Imaging in Drug Discovery and Development Raymond Gibson Senior Investigator Merck, Sharp and Dohme aaarrrccchhhiiivvveeesss aaannnddd aaabbbssstttrrraaaccctttsss... #12;Abstract With the desire to develop novel drugs faster and more cost-effectively, drug companies are searching for clear strategies to manage the complex

  16. CMVO Drug Testing Program Request for Information

    E-Print Network [OSTI]

    Mazzotti, Frank

    CMVO Drug Testing Program Request for Information TO: RE: Name (First, M.I., Last) Social Security substances testing records. Please complete this form and return it to: University of Florida CMVO Drug or she has tested positive, or refused to test, on any pre-employment drug or alcohol test administered

  17. Investigational Drug/Device Accountability Policy Introduction

    E-Print Network [OSTI]

    Subramanian, Venkat

    2/11/08 Investigational Drug/Device Accountability Policy Introduction: Good clinical research investigational drug or device used in a research trial at Washington University. This is true whether the study-initiated trial using department funds. Our institutional responsibility requires that any investigational drug

  18. A. UNIVERSITY POLICIES ON ILLEGAL DRUGS AND

    E-Print Network [OSTI]

    Wang, Yuqing

    A. UNIVERSITY POLICIES ON ILLEGAL DRUGS AND ALCOHOL In conformance with the existing law or be under the influence of illegal drugs and/or alcohol as prohibited by state and federal law at University enforcement agencies responsible for enforcing laws related to the use of illegal drugs and alcohol. Students

  19. Possible Target Options Michael A. Green

    E-Print Network [OSTI]

    McDonald, Kirk

    Possible Target Options Michael A. Green WATER COOLED SOLID TARGETS For high energy drivers, a desirable target material should have a medium to high Z. For low energy drivers the targe should be made are obvious medium Z target materials. A less obvious candidate is a titanium or niobium-titanium alloy target

  20. Detect adverse drug reactions for drug Atorvastatin Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Atorvastatin Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Atorvastatin. Major side

  1. Drug Saf . Author manuscript Discourse on safe drug use: symbolic logics and ethical aspects

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Drug Saf . Author manuscript Page /1 5 Discourse on safe drug use: symbolic logics and ethical.fainzang@orange.fr > Abstract Drug safety is not a matter for healthcare professionals alone. As actors, patients are also concerned, at three different levels: 1) with regard to their behaviour and choices of drugs, with a view

  2. Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs

    E-Print Network [OSTI]

    Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs become empowered to share personal experiences regarding prescription drugs via Web page discussion from patient-provided drug reviews on health-related web sites. We focus on the statin class

  3. Detect adverse drug reactions for drug Simvastatin Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Simvastatin Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Simvastatin. Major side

  4. Detect adverse drug reactions for drug Alendronate Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Alendronate Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Alendronate. Major side

  5. 2012 Biennial Review: Drug-Free Schools and Communities Act and Drug-Free

    E-Print Network [OSTI]

    Tullos, Desiree

    2012 Biennial Review: Drug-Free Schools and Communities Act and Drug-Free Schools & Campuses from drugs and alcohol. The University supports programs for the prevention of abuse of alcohol. Biennial Review Process Oregon State University has a long history of engaging in drug and alcohol

  6. Detect adverse drug reactions for drug Pioglitazone Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Pioglitazone Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Pioglitazone. Major side

  7. Policy on Drug-Free Workplace Policy on Drug-Free Workplace

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Drug-Free Workplace 10/26/2014 Policy on Drug-Free Workplace I. Purpose and Scope responsible decision- making regarding the use of alcohol and other drugs. Northeastern strives to maintain drug use can create. Additionally, the University is committed to enforcing policies and laws realting

  8. Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrest

    SciTech Connect (OSTI)

    Kim, Ju-Hwa; Yoo, Hye-In; Kang, Han Sung; Ro, Jungsil [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)] [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of); Yoon, Sungpil, E-mail: yoons@ncc.re.kr [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)] [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)

    2012-02-03T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Sal sensitizes antimitotic drugs-treated cancer cells. Black-Right-Pointing-Pointer Sal sensitizes them by prevention of G2 arrest and reduced cyclin D1 levels. Black-Right-Pointing-Pointer Sal also sensitizes them by increasing DNA damage and reducing p21 level. Black-Right-Pointing-Pointer A low concentration of Sal effectively sensitized the cancer cells to antimitotic drugs. -- Abstract: Here, we investigated whether Sal could sensitize cancer cells to antimitotic drugs. We demonstrated that Sal sensitized paclitaxcel (PAC)-, docetaxcel (DOC)-, vinblastin (VIN)-, or colchicine (COL)-treated cancer cell lines, suggesting that Sal has the ability to sensitize the cells to any form of microtubule-targeting drugs. Sensitization to the antimitotic drugs could be achieved with very low concentrations of Sal, suggesting that there is a possibility to minimize Sal toxicity associated with human cancer patient treatments. Sensitization by Sal increased apoptosis, which was observed by C-PARP production. Sal sensitized the cancer cells to antimitotic drugs by preventing G2 arrest, suggesting that Sal contributes to the induction of mitotic catastrophe. Sal generally reduced cyclin D1 levels in PAC-, DOC-, and VIN-treated cells. In addition, Sal treatment increased pH2AX levels and reduced p21 levels in antimitotic drugs-treated cells. These observations suggest that the mechanisms underlying Sal sensitization to DNA-damaging compounds, radiation, and microtubule-targeting drugs are similar. Our data demonstrated that Sal sensitizes cancer cells to antimitotic drugs by increasing apoptosis through the prevention of G2 arrest via conserved Sal-sensitization mechanisms. These results may contribute to the development of Sal-based chemotherapy for cancer patients treated with antimitotic drugs.

  9. Complete Chaotic Mixing in an Electro-osmotic Flow by Destabilization of Key Periodic Pathlines

    E-Print Network [OSTI]

    R. Chabreyrie; C. Chandre; P. Singh; N. Aubry

    2011-02-07T23:59:59.000Z

    The ability to generate complete, or almost complete, chaotic mixing is of great interest in numerous applications, particularly for microfluidics. For this purpose, we propose a strategy that allows us to quickly target the parameter values at which complete mixing occurs. The technique is applied to a time periodic, two-dimensional electro-osmotic flow with spatially and temporally varying Helmoltz-Smoluchowski slip boundary conditions. The strategy consists of following the linear stability of some key periodic pathlines in parameter space (i.e., amplitude and frequency of the forcing), particularly through the bifurcation points at which such pathlines become unstable.

  10. Secret key distillation from shielded two-qubit states

    E-Print Network [OSTI]

    Joonwoo Bae

    2010-09-22T23:59:59.000Z

    The quantum states corresponding to a secret key are characterized using the so-called private states, where the key part consisting of a secret key is shielded by the additional systems. Based on the construction, it was shown that a secret key can be distilled from bound entangled states. In this work, I consider the shielded two-qubit states in a key-distillation scenario and derive the conditions under which a secret key can be distilled using the recurrence protocol or the two-way classical distillation, advantage distillation together with one-way postprocessing. From the security conditions, it is shown that a secret key can be distilled from bound entangled states in a much wider range. In addition, I consider the case that in which white noise is added to quantum states and show that the classical distillation protocol still works despite a certain amount of noise although the recurrence protocol does not.

  11. Secret key distillation from shielded two-qubit states

    SciTech Connect (OSTI)

    Bae, Joonwoo [School of Computational Sciences, Korea Institute for Advanced Study, Seoul 130-722 (Korea, Republic of)

    2010-05-15T23:59:59.000Z

    The quantum states corresponding to a secret key are characterized using the so-called private states, where the key part consisting of a secret key is shielded by the additional systems. Based on the construction, it was shown that a secret key can be distilled from bound entangled states. In this work, I consider the shielded two-qubit states in a key-distillation scenario and derive the conditions under which a secret key can be distilled using the recurrence protocol or the two-way classical distillation, advantage distillation together with one-way postprocessing. From the security conditions, it is shown that a secret key can be distilled from bound entangled states in a much wider range. In addition, I consider the case that in which white noise is added to quantum states and show that the classical distillation protocol still works despite a certain amount of noise although the recurrence protocol does not.

  12. Targets and methods for target preparation for radionuclide production

    DOE Patents [OSTI]

    Zhuikov, Boris L; Konyakhin, Nicolai A; Kokhanyuk, Vladimir M; Srivastava, Suresh C

    2012-10-16T23:59:59.000Z

    The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti--Sb, Al--Sb, Cu--Sb, or Ni--Sb in order to produce radionuclides (e.g., tin-117 m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.

  13. Monotonic Target Assignment for Robotic Networks

    E-Print Network [OSTI]

    Smith, Stephen L; Bullo, Francesco

    2009-01-01T23:59:59.000Z

    Target assignment for robotic networks: Worst-case andTARGET ASSIGNMENT FOR ROBOTIC NETWORKS [6] H. W. Kuhn, “TheTarget Assignment for Robotic Networks Stephen L. Smith,

  14. Breast cancer drugs dampen vascular functions by interfering with nitric oxide signaling in endothelium

    SciTech Connect (OSTI)

    Gajalakshmi, Palanivel; Priya, Mani Krishna; Pradeep, Thangaraj; Behera, Jyotirmaya; Muthumani, Kandasamy; Madhuwanti, Srinivasan; Saran, Uttara; Chatterjee, Suvro, E-mail: soovro@yahoo.ca

    2013-06-01T23:59:59.000Z

    Widely used chemotherapeutic breast cancer drugs such as Tamoxifen citrate (TC), Capecitabine (CP) and Epirubicin (EP) are known to cause various cardiovascular side-effects among long term cancer survivors. Vascular modulation warrants nitric oxide (NO) signal transduction, which targets the vascular endothelium. We hypothesize that TC, CP and EP interference with the nitric oxide downstream signaling specifically, could lead to cardiovascular dysfunctions. The results demonstrate that while all three drugs attenuate NO and cyclic guanosine mono-phosphate (cGMP) production in endothelial cells, they caused elevated levels of NO in the plasma and RBC. However, PBMC and platelets did not show any significant changes under treatment. This implies that the drug effects are specific to the endothelium. Altered eNOS and phosphorylated eNOS (Ser-1177) localization patterns in endothelial cells were observed following drug treatments. Similarly, the expression of phosphorylated eNOS (Ser-1177) protein was decreased under the treatment of drugs. Altered actin polymerization was also observed following drug treatment, while addition of SpNO and 8Br-cGMP reversed this effect. Incubation with the drugs decreased endothelial cell migration whereas addition of YC-1, SC and 8Br-cGMP recovered the effect. Additionally molecular docking studies showed that all three drugs exhibited a strong binding affinity with the catalytic domain of human sGC. In conclusion, results indicate that TC, CP and EP cause endothelial dysfunctions via the NO–sGC–cGMP pathway and these effects could be recovered using pharmaceutical agonists of NO signaling pathway. Further, the study proposes a combination therapy of chemotherapeutic drugs and cGMP analogs, which would confer protection against chemotherapy mediated vascular dysfunctions in cancer patients. - Highlights: • NO production is reduced in endothelial cells under breast cancer drug treatment. • Cellular cGMP level is decreased under the treatments of breast cancer drugs. • Breast cancer drugs induce vasoconstriction by interfering with NO pathway. • NO donors, cGMP analogs rescue breast cancer drug induced endothelial dysfunctions.

  15. Cyclin-dependent kinase inhibitor drugs drive neutrophil granulocyte apoptosis by transcriptional inhibition of the key survival protein MCL-1 

    E-Print Network [OSTI]

    Leitch, Andrew Edward

    2011-11-25T23:59:59.000Z

    The normal physiological response to bacterial infection or wounding with threat of infection, termed inflammation, has been shown to be dysregulated in certain human diseases including (but not limited to): idiopathic ...

  16. Comparison of mutated JAK2 and ABL1 as oncogenes and drug targets in myeloproliferative disorders

    E-Print Network [OSTI]

    Walz, Christoph; Cross, Nicholas P.; Van Etten, Richard A.; Reiter, Andreas

    2008-01-01T23:59:59.000Z

    abnormality in chronic and acute leukemia that fuses PCM1 tosome cases of de novo acute leukemia and lymphoma. Ligand-disease progression to an acute leukemia state, referred to

  17. Comparison of mutated JAK2 and ABL1 as oncogenes and drug targets in myeloproliferative disorders

    E-Print Network [OSTI]

    Walz, Christoph; Cross, Nicholas P.; Van Etten, Richard A.; Reiter, Andreas

    2008-01-01T23:59:59.000Z

    episomes in T-cell acute lymphoblastic leukemia. Nat Genet.ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(associated B-cell acute lymphoblastic leukemia. Leukemia.

  18. Exchange protein activated by cAMP : drug target and biomarker in chronic lymphocytic leukemia

    E-Print Network [OSTI]

    Apaydin, Eric Andrew

    2009-01-01T23:59:59.000Z

    glucocorticoid in acute lymphoblastic leukemia cells. ” Jnot PKARI?, kills acute lymphoblastic leukemia cells, thus

  19. Biosynthesis pathway & transport of endotoxin - promising antibacterial drug targets in the Burkholderia cepacia Complex (BCC) 

    E-Print Network [OSTI]

    Bodewits, Karin

    2011-11-23T23:59:59.000Z

    Burkholderia cepacia complex (Bcc) species are opportunistic pathogens in patients with cystic fibrosis (CF), which are able to cause lethal infections. The Bcc are inherently resistant to most classes of antibiotics, ...

  20. CHARACTERIZATION OF MYCOSIN FAMILY PROTEASES, NOVEL DRUG TARGETS OF MYCOBACTERIUM TUBERCULOSIS

    E-Print Network [OSTI]

    Baird, Hilary

    2007-09-17T23:59:59.000Z

    in the cloning process because of the conservation of the Mycosins’ active sites. The most potent inhibitor will be able to bind all five Mycosins. Several sequence alignments have also been included to help characterize the Mycosin-1 protein. The evidence...

  1. Drug Target Optimization in Chronic Myeloid Leukemia Using Innovative Computational Platform

    E-Print Network [OSTI]

    Chuang, Ryan; Hall, Benjamin A.; Benque, David; Cook, Byron; Ishtiaq, Samin; Piterman, Nir; Taylor, Alex; Vardi, Moshe; Koschmieder, Steffen; Gottgens, Berthold; Fisher, Jasmin

    2015-02-03T23:59:59.000Z

    behavior. HPNRK activation via ERK in BC and CP cell lines supports cytokine independent proliferation, though knock outs reduce cytokine dependent proliferation. Notari 2006 In the presence of cytokines, both CP and BC CML show reduced proliferation (2... of the ‘‘proliferation’’ cell fate from 2 to 1. The other four successfully replicated experiments included the observations that MEK-ERK activation of HNRPK is not required for cytokine independent proliferation, that Interleukin-3 (IL-3) upregulation induces factor...

  2. A battle with superbugs : New compounds and targets against drug-resistant pathogens

    E-Print Network [OSTI]

    Haste, Nina M.

    2012-01-01T23:59:59.000Z

    Product Marinopyrrole A against MRSA, abstr F1-1501. In 49thB. (2011). Five decades of MRSA: controversy and uncertaintyin community- associated MRSA pathogenesis. Trends Microbiol

  3. Structure-based drug mechanism study and inhibitor design targeting tuberculosis

    E-Print Network [OSTI]

    Wang, Feng

    2009-05-15T23:59:59.000Z

    ...........................................................................................................40 Cloning, Expression and Purification ...........................................................40 Synthesis of the INH-NAD, PNH-NAD and BZH-NAD Adducts...............41 InhA Activity Assay..............................39 Figure 13 Crystal Structure of S94A Bound with the INH-NAD Adduct. ....................48 Figure 14 Synthesis of INH-NAD, BZH-NAD, and PNH-NAD...................................51 Figure 15 Surface Diagram of InhA in Complex with Hydrazide...

  4. Target Flexibility: An Emerging Consideration in Drug Discovery and Design Pietro Cozzini,*,,

    E-Print Network [OSTI]

    Orientale "Amedeo AVogadro", Via BoVio 6, 28100 NoVara, Italy, Institute of Pharmacy and Food Chemistry, Uni scale such that changes in the local backbone conformation are required for lid closure.12 Nuclear to biological function. Most of the pharmacology of nuclear receptor ligands has been discussed on the basis

  5. Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

    E-Print Network [OSTI]

    Taipale, Mikko

    The interaction between the HSP90 chaperone and its client kinases is sensitive to the conformational status of the kinase, and stabilization of the kinase fold by small molecules strongly decreases chaperone interaction. ...

  6. Radioactive target needs for nuclear reactor physics and nuclear astrophysics , G. Barreau1

    E-Print Network [OSTI]

    Boyer, Edmond

    Radioactive target needs for nuclear reactor physics and nuclear astrophysics B.Jurado1* , G sections of short-lived nuclei are key inputs for new generation nuclear reactor simulations and for models and reactor physics where the demand of nuclear data on unstable nuclei is strong, we describe the general

  7. Life Pure Fusion Target Designs: Status and Prospects

    SciTech Connect (OSTI)

    Amendt, P; Dunne, M; Ho, D; Lindl, J

    2011-10-20T23:59:59.000Z

    Analysis and radiation-hydrodynamics simulations for expected high-gain fusion target performance on a demonstration 1-GWe Laser Inertial Fusion Energy (LIFE) power plant are presented. The required laser energy driver is 2.2 MJ at a 0.351-{mu}m wavelength, and a fusion target gain greater than 60 at a repetition rate of 16 Hz is the design goal for economic and commercial attractiveness. A scaling-law analysis is developed to benchmark the design parameter space for hohlraum-driven central hot-spot ignition. A suite of integrated hohlraum simulations is presented to test the modeling assumptions and provide a basis for near-term experimental resolution of the key physics uncertainties on the National Ignition Facility.

  8. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    electric trains, low emission vehicles, energy-efficient textile manufacturing equipment, solar power systems,

  9. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    See discussion of this report in ETSU, AEA Technology, 2001.environment/ccl/pdf/etsu- analysis.pdf Price, L. , Blok,a report prepared by ETSU (now AEA Energy & Environment) on

  10. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    and market assessments for steam, process heating,markets with experience from the commercial sector and tend to concentrate on measures such as lighting and heating,

  11. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    less than six years. The energy audits were carried out byyears, as identified in an energy audit or through internalthe following: 86 1. Energy audit and analysis. The company

  12. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    Examples include Australia’s Energy Efficiency Best Practiceenergy efficiency projects to procure enough financial benefit for individual companies. Australia’energy efficiency and renewable energy equipment instead of the standard annual rates of between 4% and Energy Futures Australia

  13. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    concluded that the business energy and CO 2 taxes created aIncentives for Business Investments in Energy Conservationia/business/industry/ES_Petroleum_Energy_Guide.pdf Galitsky,

  14. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    STEM), as a part of the EKO Energi Agreements, provides aU. and Avasoo, D. , 2001. “EKO-Energi – Successful Voluntary

  15. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    survey of opportunities for energy-efficiency improvement, company energy plans, monitoring and energy management

  16. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    Incentives for Business Investments in Energy Conservation and Renewableincentives for adoption of energy efficiency and renewable

  17. International Experience with Key Program Elements of Industrial Energy Efficiency or Greenhouse Gas Emissions Reduction Target-Setting Programs

    E-Print Network [OSTI]

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-01-01T23:59:59.000Z

    quality management program (ISO 9001:2000) and environmentalquality management system (ISO 9001). It was also found that

  18. QKD with finite resources: secret key rates via Rényi entropies

    E-Print Network [OSTI]

    Silvestre Abruzzo; Hermann Kampermann; Markus Mertz; Dagmar Bruß

    2011-05-27T23:59:59.000Z

    A realistic Quantum Key Distribution (QKD) protocol necessarily deals with finite resources, such as the number of signals exchanged by the two parties. We derive a bound on the secret key rate which is expressed as an optimization problem over R\\'enyi entropies. Under the assumption of collective attacks by an eavesdropper, a computable estimate of our bound for the six-state protocol is provided. This bound leads to improved key rates in comparison to previous results.

  19. Security proof of practical quantum key distribution schemes

    E-Print Network [OSTI]

    Yodai Watanabe

    2005-06-29T23:59:59.000Z

    This paper provides a security proof of the Bennett-Brassard (BB84) quantum key distribution protocol in practical implementation. To prove the security, it is not assumed that defects in the devices are absorbed into an adversary's attack. In fact, the only assumption in the proof is that the source is characterized. The proof is performed by lower-bounding adversary's Renyi entropy about the key before privacy amplification. The bound reveals the leading factors reducing the key generation rate.

  20. Fake state attack on practically decoy state quantum key distribution

    E-Print Network [OSTI]

    Yong-gang Tan

    2012-02-15T23:59:59.000Z

    In this paper, security of practically decoy state quantum key distribution under fake state attack is considered. If quantum key distribution is insecure under this type of attack, decoy sources can not also provide it with enough security. Strictly analysis shows that Eve should eavesdrop with the aid of photon-number-resolving instruments. In practical implementation of decoy state quantum key distribution where statistical fluctuation is considered, however, Eve can attack it successfully with threshold detectors.

  1. Targets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesis of 2D AlloysTrails TakingRTape Mounts Last

  2. Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding

    E-Print Network [OSTI]

    Jayaram, Bhyravabotla

    Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding energy component analysis that conveys information on the physicochemical forces driving the protein for a specific protein target if not in the general case. It is here that the free energy component analysis

  3. Sandia Energy - Direct Measurement of Key Molecule Will Increase...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Direct Measurement of Key Molecule Will Increase Accuracy of Combustion Models Home Energy Transportation Energy CRF Facilities News News & Events Computational Modeling &...

  4. Key Practical Issues in Strengthening Safety Culture, INSAG-15

    Broader source: Energy.gov [DOE]

    Key Pratical Issues in Strengthening Safety Culture, INSAG-15. A report by the International Nuclear Safety Advisory Gorup, International Atomic Energy Agency, Vienna, 2002.

  5. MasterKey Cryptosystems AT&T Bell Labs

    E-Print Network [OSTI]

    Blaze, Matthew

    then be converted to a stream­ cipher via one of the usual block­chaining methods). We use the public­key encryption

  6. Pantex Plant Achieves Key Safety Milestone Ahead of Schedule...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Achieves Key Safety Milestone Ahead of Schedule | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing...

  7. Key Parameters Affecting DPF Performance Degradation and Impact...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Parameters Affecting DPF Performance Degradation and Impact on Lifetime Fuel Economy Key Parameters Affecting DPF Performance Degradation and Impact on Lifetime Fuel Economy...

  8. Sierra Geothermal's Key Find in Southern Nevada | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Geothermal's Key Find in Southern Nevada July 13, 2010 - 5:17pm Addthis Sierra Geothermal discovered temperatures hot enough for large-scale geothermal energy production at...

  9. Climate Action Planning: A Review of Best Practices, Key Elements...

    Open Energy Info (EERE)

    Planning: A Review of Best Practices, Key Elements, and Common Climate Strategies for Signatories to the American College & University Presidents' Climate Commitment Jump to:...

  10. Key Facts about the Biosciences Division | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to understand biological mechanisms relevant to bioremediation, climate change, energy production, and the protection of human health. BiosciencesDivisionKeyFactsOct20...

  11. Water dynamics clue to key residues in protein folding

    SciTech Connect (OSTI)

    Gao, Meng [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Zhu, Huaiqiu, E-mail: hqzhu@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Yao, Xin-Qiu [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China) [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Department of Biophysics, Kyoto University, Sakyo Kyoto 606-8502 (Japan); She, Zhen-Su, E-mail: she@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)

    2010-01-29T23:59:59.000Z

    A computational method independent of experimental protein structure information is proposed to recognize key residues in protein folding, from the study of hydration water dynamics. Based on all-atom molecular dynamics simulation, two key residues are recognized with distinct water dynamical behavior in a folding process of the Trp-cage protein. The identified key residues are shown to play an essential role in both 3D structure and hydrophobic-induced collapse. With observations on hydration water dynamics around key residues, a dynamical pathway of folding can be interpreted.

  12. Worldwide Trends in Energy Use and Efficiency: Key Insights from...

    Open Energy Info (EERE)

    Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Jump to: navigation, search Tool Summary...

  13. PPPL physicists win supercomputing time to simulate key energy...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    PPPL physicists win supercomputing time to simulate key energy and astrophysical phenomena By John Greenwald January 8, 2013 Tweet Widget Google Plus One Share on Facebook A...

  14. Quantum mechanical approaches to in silico enzyme characterization and drug design

    SciTech Connect (OSTI)

    Nilmeier, J P; Fattebert, J L; Jacobson, M P; Kalyanaraman, C

    2012-01-17T23:59:59.000Z

    The astonishing, exponentially increasing rates of genome sequencing has led to one of the most significant challenges for the biological and computational sciences in the 21st century: assigning the likely functions of the encoded proteins. Enzymes represent a particular challenge, and a critical one, because the universe of enzymes is likely to contain many novel functions that may be useful for synthetic biology, or as drug targets. Current approaches to protein annotation are largely based on bioinformatics. At the simplest level, this annotation involves transferring the annotations of characterized enzymes to related sequences. In practice, however, there is no simple, sequence based criterion for transferring annotations, and bioinformatics alone cannot propose new enzymatic functions. Structure-based computational methods have the potential to address these limitations, by identifying potential substrates of enzymes, as we and others have shown. One successful approach has used in silico 'docking' methods, more commonly applied in structure-based drug design, to identify possible metabolite substrates. A major limitation of this approach is that it only considers substrate binding, and does not directly assess the potential of the enzyme to catalyze a particular reaction using a particular substrate. That is, substrate binding affinity is necessary but not sufficient to assign function. A reaction profile is ultimately what is needed for a more complete quantitative description of function. To address this rather fundamental limitation, they propose to use quantum mechanical methods to explicitly compute transition state barriers that govern the rates of catalysis. Although quantum mechanical, and mixed quantum/classical (QM/MM), methods have been used extensively to investigate enzymatic reactions, the focus has been primarily on elucidating complex reaction mechanisms. Here, the key catalytic steps are known, and they use these methods quantify substrate specificity. That is, we bring the power of quantum mechanics to bear on the problem of annotating enzyme function, which is a novel approach. Although it has been clear to us at the Jacobson group for some time that enzyme specificity may be encoded in transition states, rather than simply substrate recognition, the main limitation has always been computational expense. Using a hierarchy of different methods, they can reduce the list of plausible substrates of an enzyme to a small number in most cases, but even identifying the transition states for a dozen plausible substrates requires significant computational effort, beyond what is practical using standard QM/MM methods. For this project, they have chosen two enzyme superfamilies which they have used as 'model systems' for functional assignment. The enolase superfamily is a large group of {alpha}-{beta} barrel enzymes with highly diverse substrates and chemical transformations. Despite decades of work, over a third of the superfamily remains unassigned, which means that the remaining cases are by definition difficult to assign. They have focused on acid sugar dehydratases, and have considerable expertise on the matter. They are also interested in the isoprenoid synthase superfamily, which is of central interest to the synthetic biology community, because these enzymes are used by nature to create complex rare natural products of medicinal value. the most notable example of this is the artemisinin, an antimalarial compound that is found in trace amounts in the wormwod root. From the standpoint of enzyme function assignment, these enzymes are intriguing because they use a small number of chemically simple substrates to generate, potentially, tens of thousands of different products. Hence, substrate binding specificity is only a small part of the challenge; the key is determining how the enzyme directs the carbocation chemistry to specific products. These more complex modeling approaches clearly require quantum mechanical methods.

  15. Neuroimaging for drug addiction and related behaviors

    SciTech Connect (OSTI)

    Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

    2011-10-01T23:59:59.000Z

    In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

  16. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01T23:59:59.000Z

    treatment); health care costs (drug-related illnesses, injuries); reduced performance in school; reduced performance at workplace; poor parenting, child abuse;

  17. Emerging pathogens: Dynamics, mutation and drug resistance

    SciTech Connect (OSTI)

    Perelson, A.S.; Goldstein, B.; Korber, B.T. [and others

    1997-10-01T23:59:59.000Z

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objectives of this project were to develop models of the spread of pathogens, such as HIV-1 and influenza, in humans, and then to use the models to address the possibility of designing appropriate drug therapies that may limit the ability of the pathogen to escape treatment by mutating into a drug resistant form. We have developed a model of drug-resistance to amantidine and rimantadine, the two major antiviral drugs used to treat influenza, and have used the model to suggest treatment strategies during an epidemic.

  18. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01T23:59:59.000Z

    survey found that fourth-tier drug copayments averaged $85 in 2009 (KFF, Differential cost sharing is one utilization management technique plans

  19. Thailand-Key Results and Policy Recommendations for Future Bioenergy...

    Open Energy Info (EERE)

    through its Alternative Energy Development Plan, has set a target to increase biofuel production to five billion litres by 2022. The Thai Government sees this expansion as...

  20. Vehicle Electrification is Key to Reducing Petroleum Dependency...

    Broader source: Energy.gov (indexed) [DOE]

    Petroleum Dependency and Greenhouse Gas Emission More Documents & Publications Energy Storage R&D and ARRA Battery Pack Requirements and Targets Validation FY 2009 DOE Vehicle...

  1. IBMS BoneKEy. 2009 April;6(4):132-149 http://www.bonekey-ibms.org/cgi/content/full/ibmske;6/4/132

    E-Print Network [OSTI]

    and osteoporosis, yet uniquely ­ without targeting the resident fat or bone cell. IBMS BoneKEy. 2009 April;6(4):132-149. ©2009 International Bone & Mineral Society Introduction Osteoporosis and obesity, two of the most billion dollars in annual health service costs. (1) Osteoporosis, a disease characterized by diminished

  2. Mind Your Manners: Socially Appropriate Wireless Key Establishment for Groups

    E-Print Network [OSTI]

    Xu, Wenyuan

    group key establish- ment. We identify seven social and situational factors which impact group formationMind Your Manners: Socially Appropriate Wireless Key Establishment for Groups Cynthia Kuo Ahren Studer Adrian Perrig Carnegie Mellon University {cykuo, astuder, perrig}@cmu.edu ABSTRACT Group

  3. Public Key Encryption that Allows PIR Queries Eyal Kushilevitz

    E-Print Network [OSTI]

    Public Key Encryption that Allows PIR Queries Dan Boneh Eyal Kushilevitz Rafail Ostrovsky William E to create a public- key encryption scheme for Alice that allows PIR searching over encrypted documents. Our allows for Single-Database PIR writing with sublinear communication complexity, which we consider

  4. Public Key Encryption that Allows PIR Queries Eyal Kushilevitz

    E-Print Network [OSTI]

    Ostrovsky, Rafail

    Public Key Encryption that Allows PIR Queries Dan Boneh Eyal Kushilevitz Rafail Ostrovsky William E. In this paper, we show how to create a public-key encryption scheme for Alice that allows PIR searching over allows for Single-Database PIR writing with sublinear communication complexity, which we consider

  5. Key ornamental innovations facilitate diversification in an avian radiation

    E-Print Network [OSTI]

    Rubenstein, Dustin R.

    Key ornamental innovations facilitate diversification in an avian radiation Rafael Maiaa,1 , Dustin novel ways of interacting with the en- vironment (key innovations) play a fundamental role in promoting evolution of orna- mental traits. Because selection can operate only on existing vari- ation, the tendency

  6. Energy Security: A Key Requirement forSustainable Development

    E-Print Network [OSTI]

    1 Energy Security: A Key Requirement forSustainable Development Perspective and Action Plan Robert Card Under Secretary US Department of Energy August 30, 2002 Session One: Maintaining Energy Security WSSD Side Event Energy for Sustainable Development IEA/UNEP/Eskom #12;2 Energy Security is a Key

  7. Reflective cracking of shear keys in multi-beam bridges

    E-Print Network [OSTI]

    Sharpe, Graeme Peter

    2009-06-02T23:59:59.000Z

    ..............................................2 Figure 2: PCI 33? Box Girder with Shear Keys................................................................5 Figure 3: TxDOT 34? Box Girder with Shear Keys .........................................................5 Figure 4: Test Specimen... Under Tension.........................................................................12 Figure 5: Test Specimen in Bending ...............................................................................12 Figure 6: Test Specimen in Shear...

  8. USB KEY PROFILE MANAGER FOR MOZILLA A Project Report

    E-Print Network [OSTI]

    Pollett, Chris

    USB KEY PROFILE MANAGER FOR MOZILLA A Project Report Presented to The Faculty of the Department FOR THE UNIVERSITY _____________________________________________________ 3 #12;ABSTRACT USB KEY PROFILE MANAGER FOR MOZILLA By Yun Zhou Mozilla's profile manager allows users to save their private information

  9. Secret-Key Generation using Correlated Sources and Channels

    E-Print Network [OSTI]

    Khisti, Ashish

    1 Secret-Key Generation using Correlated Sources and Channels Ashish Khisti, Member, IEEE of generating a shared secret key between two terminals in a joint source-channel setup -- the terminals to correlated discrete memoryless source sequences. We establish lower and upper bounds on the secret

  10. Hybrid Secret Key Escrow Mechanisms as Counters Esa Hyytia

    E-Print Network [OSTI]

    Hyytiä, Esa

    Hybrid Secret Key Escrow Mechanisms as Counters Esa Hyyti¨a Telecommunications Research Center can be used in several ways. One interesting application of the Shamir's secret sharing scheme in the context of privacy aware traffic monitoring is to escrow a secret key after m suspicious events have been

  11. accident conditions key: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    accident conditions key First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Range Condition: Key to...

  12. Security Notions for Quantum Public-Key Cryptography

    E-Print Network [OSTI]

    Takeshi Koshiba

    2007-02-19T23:59:59.000Z

    It is well known that Shor's quantum algorithm for integer factorization can break down the RSA public-key cryptosystem, which is widely used in many cryptographic applications. Thus, public-key cryptosystems in the quantum computational setting are longed for cryptology. In order to define the security notions of public-key cryptosystems, we have to model the power of the sender, receiver, adversary and channel. While we may consider a setting where quantum computers are available only to adversaries, we generally discuss what are the right security notions for (quantum) public-key cryptosystems in the quantum computational setting. Moreover, we consider the security of quantum public-key cryptosystems known so far.

  13. Apparatus, system, and method for synchronizing a timer key

    DOE Patents [OSTI]

    Condit, Reston A; Daniels, Michael A; Clemens, Gregory P; Tomberlin, Eric S; Johnson, Joel A

    2014-04-22T23:59:59.000Z

    A timer key relating to monitoring a countdown time of a countdown routine of an electronic device is disclosed. The timer key comprises a processor configured to respond to a countdown time associated with operation of the electronic device, a display operably coupled with the processor, and a housing configured to house at least the processor. The housing has an associated structure configured to engage with the electronic device to share the countdown time between the electronic device and the timer key. The processor is configured to begin a countdown routine based at least in part on the countdown time, wherein the countdown routine is at least substantially synchronized with a countdown routine of the electronic device when the timer key is removed from the electronic device. A system and method for synchronizing countdown routines of a timer key and an electronic device are also disclosed.

  14. Practical issues in quantum-key-distribution postprocessing

    SciTech Connect (OSTI)

    Fung, C.-H. Fred; Chau, H. F. [Department of Physics and Center of Theoretical and Computational Physics, University of Hong Kong, Pokfulam Road (Hong Kong); Ma Xiongfeng [Institute for Quantum Computing and Department of Physics and Astronomy, University of Waterloo, 200 University Ave W., Waterloo, Ontario, Canada N2L 3G1 (Canada)

    2010-01-15T23:59:59.000Z

    Quantum key distribution (QKD) is a secure key generation method between two distant parties by wisely exploiting properties of quantum mechanics. In QKD, experimental measurement outcomes on quantum states are transformed by the two parties to a secret key. This transformation is composed of many logical steps (as guided by security proofs), which together will ultimately determine the length of the final secret key and its security. We detail the procedure for performing such classical postprocessing taking into account practical concerns (including the finite-size effect and authentication and encryption for classical communications). This procedure is directly applicable to realistic QKD experiments and thus serves as a recipe that specifies what postprocessing operations are needed and what the security level is for certain lengths of the keys. Our result is applicable to the BB84 protocol with a single or entangled photon source.

  15. New safety concerns over diabetes drugs Two drugs commonly prescribed to treat diabetes

    E-Print Network [OSTI]

    Feigon, Brooke

    New safety concerns over diabetes drugs Two drugs commonly prescribed to treat diabetes double of Type II Diabetes. Prescriptions for the drugs, known as thiazolidinediones, have doubled over the last. The results are published in the August edition of the journal Diabetes Care. Congregation 2007 page 5­9 Race

  16. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

    1984-01-01T23:59:59.000Z

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reaction accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  17. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

    1987-01-01T23:59:59.000Z

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reactions accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  18. LIFE Target Fabrication Research Plan Sept 2008

    SciTech Connect (OSTI)

    Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

    2008-11-10T23:59:59.000Z

    The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

  19. POLICY STATEMENT ON DRUG-FREE CAMPUS*

    E-Print Network [OSTI]

    Karsai, Istvan

    11 POLICY STATEMENT ON DRUG-FREE CAMPUS* It is the policy of ETSU that the unlawful manufacture, distribution, possession, use of alcohol and illicit drugs on the ETSU campus, in the workplace (on or off campus), on property owned or controlled by ETSU, or as part of any activity of ETSU is strictly

  20. Novel polyoxazolines polymer drug delivery platform

    E-Print Network [OSTI]

    performed with 4 different polymers in multi- drug resistant (MCF7/ADR) human adenocarcinoma cells, non-resistant (MCF7) human adenocarcinoma cells and Madin-Darby canine kidney (MDCK) cells. All polymers were found lines. 2. To investigate the effect of the addition of drugs to the polymers on cell toxicity, micelles

  1. Pricing in the Market for Anticancer Drugs

    E-Print Network [OSTI]

    Howard, David H.

    In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab— brand name Yervoy—at $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

  2. Prescription Drug List --To be used by members

    E-Print Network [OSTI]

    Mullins, Dyche

    Prescription Program Drug List -- To be used by members (both National Accounts and Local Group), who have a tiered drug plan. Anthem Blue Cross prescription drug benefits include medications available on the Anthem Drug List. Our prescription drug benefits can offer potential savings when your

  3. Comparisons on thin and thick neutron target for low energy proton beam

    SciTech Connect (OSTI)

    Zhong, B.; Yu, G.; Wang, X.; Wang, K. [Dept. of Engineering Physics, Tsinghua Univ., Beijing 100084 (China)

    2012-07-01T23:59:59.000Z

    As the progress on accelerator physics and neutronics, the compact neutron sources driven by low energy and high intensity beam are becoming extensively developed and researched all around the world. The neutron target of an accelerator driven neutron source is one of the key components, and the stability of the neutron target affect the operation and performance of the neutron facility. When a low energy proton is projected to the beryllium target, the main reaction is the inelastic scattering between the proton and extra-nuclear electrons. As the decreasing of proton energy, the rate of elastic scattering between proton and target nucleus begins to increase. When the energy of proton is very low, the pickup charge reaction begins to appear. Focus on the problems brought by high intensity proton beam such as proton implantation, radiation damages, heat deposition and gas production, we performed sufficient numerical simulations for both thin and thick target determined by proton range. The results show that the critical problem for thick target is the proton implantation, causing the forming of bubbles and beryllium flaked in vacuum. The thin target sacrifices a little neutron yield, but avoid the proton stopped in target, and decrease the radiation damage and energy deposition. (authors)

  4. Radioactive targets for neutron-induced cross section measurements

    SciTech Connect (OSTI)

    Kronenberg, A. (Andreas); Bond, E. M. (Evelyn M.); Glover, S. E. (Samuel E.); Rundberg, R. S. (Robert S.); Vieira, D. J. (David J.); Esch, E. I. (Ernst-Ingo); Reifarth, R. (Rene); Ullmann, J. L. (John L.); Haight, Robert C.; Rochmann, D. (Dimitri)

    2004-01-01T23:59:59.000Z

    Measurements using radioactive targets are important for the determination of key reaction path ways associated with the synthesis of the elements in nuclear astrophysics (sprocess), advanced fuel cycle initiative (transmutation of radioactive waste), and stockpile stewardship. High precision capture cross-section measurements are needed to interpret observations, predict elemental or isotopical ratios, and unobserved abundances. There are two new detector systems that are presently being commissioned at Los Alamos National Laboratory for very precise measurements of (n,{gamma}) and (n,f) cross-sections using small quantities of radioactive samples. DANCE (Detector for Advanced Neutron-Capture Experiments), a 4 {pi} gamma array made up of 160 BaF{sub 2} detectors, is designed to measure neutron capture cross-sections of unstable nuclei in the low-energy range (thermal to {approx}500 keV). The high granularity and high detection efficiency of DANCE, combined with the high TOF-neutron flux available at the Lujan Center provides a versatile tool for measuring many important cross section data using radioactive and isotopically enriched targets of about 1 milligram. Another powerful instrument is the Lead-slowing down spectrometer (LSDS), which will enable the measurement of neutron-induced fission cross-section of U-235m and other short-lived actinides in a energy range from 1-200 keV with sample sizes down to 10 nanograms. Due to the short half-life of the U-235m isomer (T{sub 1/2} = 26 minutes), the samples must be rapidly and repeatedly extracted from its {sup 239}Pu parent. Since {sup 239}Pu is itself highly fissile, the separation must not only be rapid, but must also be of very high purity (the Pu must be removed from the U with a decontamination factor >10{sup 12}). Once extracted and purified, the {sup 235m}U isomer would be electrodeposited on solar cells as a fission detector and placed within the LSDS for direct (n,f) cross section measurements. The production of radioactive targets of a few milligrams will be described as well as the containment for safe handling of these targets at the Lujan Center at LANSCE. To avoid any contamination, the targets are electrochemically fixed onto thin Ti foils and two foils are placed back to back to contain the radioactive material within. This target sandwich is placed in a cylinder made of aluminum with thin translucent windows made of Kapton. Actinides targets, such as {sup 234,235,236,238}U, {sup 237}Np, and {sup 239}Pu are prepared by electrodeposition or molecular plating techniques. Target thicknesses of 1-2 mg/cm{sup 2} with sizes of 1 cm{sup 2} or more have been made. Other targets will be fabricated from separation of irradiated isotopically enriched targets, such as {sup 155}Eu from {sup 154}Sm,{sup 171}Tm from {sup 170}Er, and {sup 147}Pm from {sup 146}Nd, which has been irradiated in the high flux reactor at ILL, Grenoble. A radioactive sample isotope separator (RSIS) is in the process of being commissioned for the preparation of other radioactive targets. A brief summary of these experiments and the radioactive target preparation technique will be given.

  5. anti-tuberculosis drug ethionamide: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  6. anti-parkinsonian drug selegiline: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  7. Target 4 Flight Path 90L (FIRE House) Target 4 Flight Path...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and industrial research. LANSCE has two spallation neutron sources: the Manuel Lujan Jr. Neutron Scattering Center (Target-1) and the Weapons Neutron Research facility (Target-4)....

  8. Qualified Target Industry Tax Refund (Florida)

    Broader source: Energy.gov [DOE]

    The Qualified Target Industry Tax Refund incentive is available for companies that create high wage jobs in targeted high value-added industries. The incentive refunds up to $3,000 per new full...

  9. Targets and processes for fabricating same

    DOE Patents [OSTI]

    Cowan, Thomas (Dresden, DE); Malekos, Steven (Reno, NV); Korgan, Grant (Reno, NV); Adams, Jesse (Reno, NV); Sentoku, Yasuhiko (Reno, NV); Le Galloudec, Nathalie (Reno, NV); Fuchs, Julien (Paris, FR)

    2012-07-24T23:59:59.000Z

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  10. Review of the Renewable Energy Target

    E-Print Network [OSTI]

    Peters, Richard

    Review of the Renewable Energy Target Response to Expert Panel's Call for Submissions Paper #12;NSW Government Submission to the Review of the Renewable Energy Target, May 2014 2/20 Contents EXECUTIVE SUMMARY........................................................................................................................... 3 RENEWABLE ENERGY IN NSW

  11. Nanoparticles for targeting the infarcted heart

    E-Print Network [OSTI]

    Dvir, Tal

    We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in ...

  12. Chest Swelling and Fever in an Intravenous Drug User

    E-Print Network [OSTI]

    Grijalva, Ray A.; Ritter, Michael; Langdorf, Mark I.

    2008-01-01T23:59:59.000Z

    aeruginosa serotype 011 from drug addicts. J Infect Dis,JA, Pierre JD. Injection drug use in North America. Infectand Fever in an Intravenous Drug User Ray A. Grijalva Jr. ,

  13. RESEARCH Open Access Impact of physical incompatibility on drug mass

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    RESEARCH Open Access Impact of physical incompatibility on drug mass flow rates: example drugs simultaneously but through limited venous accesses. Several intravenous therapies have rates of drugs infused simultaneously to the patient, through an in vitro study. Methods: Furosemide

  14. Drug Discovery and Development from Marine Biology-Based Research

    E-Print Network [OSTI]

    Jawitz, James W.

    Drug Discovery and Development from Marine Biology- Based Research Oceanyx Pharmaceuticals is a novel drug discovery and development company that leverages marine biology-based natural identified two lead candidates, largazole and apratoxin, as potential drug candidates for the treatment

  15. Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug

    E-Print Network [OSTI]

    Hill, Wendell T.

    Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug manufacturing, drug delivery, and medical diagnostics. By learning how substances behave differently's Nanotechnology Center are creating novel tools and developing new methods for crucial research areas of drug

  16. Prescription Drug Monitoring Programs: Examining Limitations and Future Approaches

    E-Print Network [OSTI]

    Griggs, Christopher A.; Weiner, Scott G.; Feldman, James A.

    2015-01-01T23:59:59.000Z

    Li G, Brady JE, Lang B, et al. Prescription drug monitoringand drug overdose mortality. Inj Epidemiol. 2014;1:1-9.EM, Desai HA. Prescription drug monitoring programs and

  17. FORMATION OF A PHYSICALLY STABLE AMORPHOUS DRUG COMPLEX

    E-Print Network [OSTI]

    MacLean, Jenifer Anne

    2010-12-16T23:59:59.000Z

    ABSTRACT In this paper we explore the use of Neusilin, an inorganic magnesium aluminometasilicate, to stabilize the amorphous form of an acidic drug a neutral drug and two basic drugs. Both cryomilling and ball milling of ...

  18. WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    14 WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria Vincent Breton, Doman Kim ................................................................................ 354 14.2 Grid-Enabled Drug Discovery .................................................. 354 14.2.1 In Silico Drug Discovery: Requirements and Grid Added Value

  19. A resorbable polymeric microreservoir device for controlled release drug delivery

    E-Print Network [OSTI]

    Grayson, Amy Catherine Richards, 1975-

    2003-01-01T23:59:59.000Z

    The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

  20. Key Factors in Displacement Ventilation Systems for Better IAQ

    E-Print Network [OSTI]

    Wang, X.; Chen, J.; Li, Y.; Wang, Z.

    2006-01-01T23:59:59.000Z

    This paper sets up a mathematical model of three-dimensional steady turbulence heat transfer in an air-conditioned room of multi-polluting heat sources. Numerical simulation helps identify key factors in displacement ventilation systems that affect...

  1. Daylight quantum key distribution over 1.6 km

    E-Print Network [OSTI]

    Buttler, W T; Lamoreaux, S K; Morgan, G L; Nordholt, J E; Peterson, C G

    2000-01-01T23:59:59.000Z

    Quantum key distribution (QKD) has been demonstrated over a point-to-point transmission distance brings QKD a step closer to surface-to-satellite and other long-distance applications.

  2. Reactive Support and Voltage Control Service: Key Issues and Challenges

    E-Print Network [OSTI]

    Gross, George

    reactive support and voltage control services. Keywords ­ Competitive Electricity Markets, Reactive PowerReactive Support and Voltage Control Service: Key Issues and Challenges George Gross^, Paolo Marannino° and Gianfranco Chicco* ^ Department of Electrical and Computer Engineering, University

  3. Detailed Description of Key NIF Milestones for NNSA Description

    E-Print Network [OSTI]

    1 Detailed Description of Key NIF Milestones for NNSA Short Description NIC EP Rev 4.0 Approved = Milestone Reporting Tool, which NNSA uses to support quarterly status reporting of NIC Level 1-2 milestones

  4. Intelligence perfecting the mute keys: Edgar Bowers and Music

    E-Print Network [OSTI]

    Smith, Kevin

    2003-01-01T23:59:59.000Z

    a Generation Know Its Story: The Edgar Bowers Conference andperfecting the mute keys: Edgar Bowers and Music” by C.and model for the poetry of Edgar Bowers. From his earliest

  5. Security bounds for efficient decoy-state quantum key distribution

    E-Print Network [OSTI]

    Marco Lucamarini; James F. Dynes; Bernd Fröhlich; Zhiliang Yuan; Andrew J. Shields

    2015-03-25T23:59:59.000Z

    Information-theoretical security of quantum key distribution (QKD) has been convincingly proven in recent years and remarkable experiments have shown the potential of QKD for real world applications. Due to its unique capability of combining high key rate and security in a realistic finite-size scenario, the efficient version of the BB84 QKD protocol endowed with decoy states has been subject of intensive research. Its recent experimental implementation finally demonstrated a secure key rate beyond 1 Mbps over a 50 km optical fiber. However the achieved rate holds under the restrictive assumption that the eavesdropper performs collective attacks. Here, we review the protocol and generalize its security. We exploit a map by Ahrens to rigorously upper bound the Hypergeometric distribution resulting from a general eavesdropping. Despite the extended applicability of the new protocol, its key rate is only marginally smaller than its predecessor in all cases of practical interest.

  6. Efficiency in Quantum Key Distribution Protocols using entangled Gaussian states

    E-Print Network [OSTI]

    Carles Rodó

    2010-05-14T23:59:59.000Z

    Efficiency is a key issue in any real implementation of a cryptographic protocol since the physical resources are not unlimited. We will first show that Quantum Key Distribution is possible with an "Entanglement based" scheme with NPPT symmetric Gaussian states in spite of the fact that these systems cannot be distilled with Gaussian operations (they are all bound entangled). In this work we analyze the secrecy properties of Gaussian states under Gaussian operations. Although such operations are useless for quantum distillation, we prove that it is possible to distill efficiently a secret key secure against finite coherent attacks from sufficiently entangled Gaussian states with non-positive partial transposition. Moreover, all such states allow for efficient key distillation, when the eavesdropper is assumed to perform individual attacks before in an efficient way.

  7. Secret-Key Generation Using Correlated Sources and Channels

    E-Print Network [OSTI]

    Khisti, Ashish

    We study the secret-key capacity in a joint source-channel coding setup-the terminals are connected over a discrete memoryless channel and have access to side information, modelled as a pair of discrete memoryless source ...

  8. Self-referenced continuous-variable quantum key distribution

    E-Print Network [OSTI]

    Soh, Daniel B S; Coles, Patrick J; Lütkenhaus, Norbert; Camacho, Ryan M; Urayama, Junji; Sarovar, Mohan

    2015-01-01T23:59:59.000Z

    We introduce a new continuous-variable quantum key distribution (CV-QKD) protocol, self-referenced CV-QKD, that eliminates the need for transmission of a high-power local oscillator between the communicating parties. In this protocol, each signal pulse is accompanied by a reference pulse (or a pair of twin reference pulses), used to align Alice's and Bob's measurement bases. We present a proof-of-principle, fiber-based experimental demonstration of the protocol and quantify the expected secret key rates by expressing them in terms of experimental parameters. Our analysis of the secret key rate fully takes into account the inherent uncertainty associated with the quantum nature of the reference pulse(s) and quantifies the limit at which the theoretical key rate approaches that of the respective conventional protocol that requires local oscillator transmission. The self-referenced protocol greatly simplifies the hardware required for CV-QKD, especially for potential integrated photonics implementations of trans...

  9. Key Factors in Displacement Ventilation Systems for Better IAQ 

    E-Print Network [OSTI]

    Wang, X.; Chen, J.; Li, Y.; Wang, Z.

    2006-01-01T23:59:59.000Z

    This paper sets up a mathematical model of three-dimensional steady turbulence heat transfer in an air-conditioned room of multi-polluting heat sources. Numerical simulation helps identify key factors in displacement ventilation systems that affect...

  10. Platforms and Methods for Acoustic Detection and Monitoring of Key

    E-Print Network [OSTI]

    Hawai'i at Manoa, University of

    #12;Platforms and Methods for Acoustic Detection and Monitoring of Key Ecosystem Properties Nils Olav Handegard #12;· Introduction · Platforms carrying acoustics · Methods · Applications ­ What we have done · Applications ­ What we would like to do #12;· Introduction · Platforms carrying acoustics

  11. W-like bound entangled states and secure key distillation

    E-Print Network [OSTI]

    Remigiusz Augusiak; Pawel Horodecki

    2009-09-09T23:59:59.000Z

    We construct multipartite entangled states with underlying W-type structure satisfying positive partial transpose (PPT) condition under any (N-1)|1 partition. Then we show how to distill N-partite secure key form the states using two different methods: direct application of local filtering and novel random key distillation scheme in which we adopt the idea form recent results on entanglement distillation. Open problems and possible implications are also discussed.

  12. Security of quantum key distribution with arbitrary individual imperfections

    E-Print Network [OSTI]

    Øystein Marøy; Lars Lydersen; Johannes Skaar

    2010-06-01T23:59:59.000Z

    We consider the security of the Bennett-Brassard 1984 (BB84) protocol for Quantum Key Distribution (QKD), with arbitrary individual imperfections simultaneously in the source and detectors. We provide the secure key generation rate, and show that only two parameters must be bounded to ensure security; the basis dependence of the source and a detector blinding parameter. The system may otherwise be completely uncharacterized and contain large losses.

  13. Quantum Public-Key Encryption with Information Theoretic Security

    E-Print Network [OSTI]

    Jiangyou Pan; Li Yang

    2012-02-20T23:59:59.000Z

    We propose a definition for the information theoretic security of a quantum public-key encryption scheme, and present bit-oriented and two-bit-oriented encryption schemes satisfying our security definition via the introduction of a new public-key algorithm structure. We extend the scheme to a multi-bitoriented one, and conjecture that it is also information theoretically secure, depending directly on the structure of our new algorithm.

  14. Securing a Quantum Key Distribution Network Using Secret Sharing

    E-Print Network [OSTI]

    Barnett, Stephen M

    2012-01-01T23:59:59.000Z

    We present a simple new technique to secure quantum key distribution relay networks using secret sharing. Previous techniques have relied on creating distinct physical paths in order to create the shares. We show, however, how this can be achieved on a single physical path by creating distinct logical channels. The technique utilizes a random 'drop-out' scheme to ensure that an attacker must compromise all of the relays on the channel in order to access the key.

  15. Proper Usage of Drugs and Chemicals in Food Animals

    E-Print Network [OSTI]

    Faries Jr., Floron C.

    2002-02-15T23:59:59.000Z

    Federal regulations exist to ensure the proper distribution and usage of veterinary drugs and to prevent adulteration of the food supply with illegal drug residues through drug misuse in food produc- ing animals. The Food and Drug Administration... of omission or commission, violative residues in livestock and poultry (by irresponsible and illegal distribution and use of drugs) violates state and federal laws. When FSIS inspectors detect violative drug residues in food products derived from ani- mals...

  16. E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

  17. Emergence of HIV-1 Drug Resistance During Antiretroviral Treatment

    E-Print Network [OSTI]

    2007-04-20T23:59:59.000Z

    Smith and Wahl (2005) used an impulsive differential equation to model drug ... In Smith (2006), the dynamics of drug are modeled by impulsive differential ...

  18. DOE Laboratories Help Develop Promising New Cancer Fighting Drug...

    Office of Environmental Management (EM)

    Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm...

  19. Apoferritin-based nanomedicine platform for drug delivery: equilibrium...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA. Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study...

  20. antiepileptic drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of drug design and development Bommarius Reading Jan 15 Tutorial Sherrill, David 28 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  1. Overview of Indian Hydrogen Program and Key Safety Issues of...

    Broader source: Energy.gov (indexed) [DOE]

    Power Plants * Targets up to 2020 SIAM 6 * Prototypes Programs in India * Prototypes * IC Engine based devices * Hydrogen fuelled motorcycles, three wheeler & Small Cars O i P j t...

  2. SimTable key tool for preparing, responding to wildfire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    examine proton radiography of brain mockup March, 25 2013 - The use of such a high-energy proton beam is ideal for imaging small tumors within patients for targeted proton...

  3. From the Editor Knife Features of Key Gamma

    E-Print Network [OSTI]

    West, Stuart

    and the Anxiety State Anxiety Neurosis Interview Drug Addiction and Its Remedies A Wonder Brain Disease Treatment. The Stethoscope has chosen this week's Cover Story on Psychiatric illness to focus on the causes, treatment, care? The Treatment of Psychiatric Illness Psychological Treatment General Measures or Simple Psychotherapy Simple

  4. Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile

    SciTech Connect (OSTI)

    Koenig, Xaver; Kovar, Michael; Rubi, Lena; Mike, Agnes K.; Lukacs, Peter; Gawali, Vaibhavkumar S.; Todt, Hannes [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Hilber, Karlheinz, E-mail: karlheinz.hilber@meduniwien.ac.at [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Sandtner, Walter [Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna (Austria)

    2013-12-01T23:59:59.000Z

    The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licenced as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Na{sub v}1.5 sodium and Ca{sub v}1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (? 10 ?M) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. - Highlights: • We study effects of anti-addiction drug ibogaine on ionic currents in cardiomyocytes. • We assess the cardiac ion channel profile of ibogaine. • Ibogaine inhibits hERG potassium, sodium and calcium channels. • Ibogaine’s effects on ion channels are a potential source of cardiac arrhythmias. • 18-Methoxycoronaridine has a lower affinity for cardiac ion channels than ibogaine.

  5. PLUTONIUM-238 PRODUCTION TARGET DESIGN STUDIES

    SciTech Connect (OSTI)

    Hurt, Christopher J [ORNL; Wham, Robert M [ORNL; Hobbs, Randall W [ORNL; Owens, R Steven [ORNL; Chandler, David [ORNL; Freels, James D [ORNL; Maldonado, G Ivan [ORNL

    2014-01-01T23:59:59.000Z

    A new supply chain is planned for plutonium-238 using existing reactors at the Oak Ridge National Laboratory (ORNL) and Idaho National Laboratory (INL) and existing chemical recovery facilities at ORNL. Validation and testing activities for new irradiation target designs have been conducted in three phases over a 2 year period to provide data for scale-up to production. Target design, qualification, target fabrication, and irradiation of fully-loaded targets have been accomplished. Data from post-irradiation examination (PIE) supports safety analysis and irradiation of future target designs.

  6. The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds

    SciTech Connect (OSTI)

    Marks, Louise, E-mail: louise.marks@astrazeneca.com [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)] [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom); Borland, Samantha; Philp, Karen; Ewart, Lorna; Lainée, Pierre; Skinner, Matthew [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)] [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom); Kirk, Sarah [Innovative Medicines, Discovery Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)] [Innovative Medicines, Discovery Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom); Valentin, Jean-Pierre [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)] [Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG (United Kingdom)

    2012-09-01T23:59:59.000Z

    Despite rigorous preclinical and clinical safety evaluation, adverse cardiac effects remain a leading cause of drug attrition and post-approval drug withdrawal. A number of cardiovascular screens exist within preclinical development. These screens do not, however, provide a thorough cardiac liability profile and, in many cases, are not preventing the progression of high risk compounds. We evaluated the suitability of the anaesthetised guinea-pig for the assessment of drug-induced changes in cardiovascular parameters. Sodium pentobarbitone anaesthetised male guinea-pigs received three 15 minute intravenous infusions of ascending doses of amoxicillin, atenolol, clonidine, dobutamine, dofetilide, flecainide, isoprenaline, levosimendan, milrinone, moxifloxacin, nifedipine, paracetamol, verapamil or vehicle, followed by a 30 minute washout. Dose levels were targeted to cover clinical exposure and above, with plasma samples obtained to evaluate effect/exposure relationships. Arterial blood pressure, heart rate, contractility function (left ventricular dP/dt{sub max} and QA interval) and lead II electrocardiogram were recorded throughout. In general, the expected reference compound induced effects on haemodynamic, contractility and electrocardiographic parameters were detected confirming that all three endpoints can be measured accurately and simultaneously in one small animal. Plasma exposures obtained were within, or close to the expected clinical range of therapeutic plasma levels. Concentration–effect curves were produced which allowed a more complete understanding of the margins for effects at different plasma exposures. This single in vivo screen provides a significant amount of information pertaining to the cardiovascular risk of drug candidates, ultimately strengthening strategies addressing cardiovascular-mediated compound attrition and drug withdrawal. -- Highlights: ? Evaluation of the anaesthetised guinea-pig to determine cardiac liability. ? Haemodynamic, contractility, ECG parameters and plasma exposure all measurable. ? Single small animal model offering extensive evaluation of a drug's CV risk. ? Potential to strengthen drug discovery cardiovascular strategy. ? Potential to halt progression of drugs with CV liability, reducing drug attrition.

  7. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01T23:59:59.000Z

    how drug policy reformers used the ballot initiative processand future directions for reformers. Bock’s (2000) work isto analyze how drug policy reformers frame their actions and

  8. Ignition of deuterium-tritium fuel targets

    DOE Patents [OSTI]

    Musinski, D.L.; Mruzek, M.T.

    1991-08-27T23:59:59.000Z

    Disclosed is a method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom. 5 figures.

  9. Ignition of deuterium-trtium fuel targets

    DOE Patents [OSTI]

    Musinski, Donald L. (Saline, MI); Mruzek, Michael T. (Britton, MI)

    1991-01-01T23:59:59.000Z

    A method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom.

  10. Thin-thick hydrogen target for nuclear physics

    SciTech Connect (OSTI)

    Gheller, J.-M.; Juster, F.-P.; Authelet, G. [CEA Saclay, Irfu/SACM, F-91191 Gif-Sur-Yvette cedex (France); Vinyar, I. [PELIN Limited Liability Company 27 A, Gzhatskaya Str, office 103 St. Petersbourg 195220 (Russian Federation); Relland, J. [CEA Saclay, Irfu/SIS, F-91191 Gif-Sur-Yvette cedex (France); Commeaux, C. [Institut de Physique Nucléaire, campus Universitaire-Bat 103, 91406 Orsay cedex (France)

    2014-01-29T23:59:59.000Z

    In spectroscopic studies of unstable nuclei, hydrogen targets are of key importance. The CHyMENE Project aims to provide to the nuclear physics community a thin and pure solid windowless hydrogen or deuterium target. CHyMENE project must respond to this request for the production of solid Hydrogen. The solid hydrogen target is produced in a continuous flow (1 cm/s) by an extrusion technique (developed with the PELIN laboratory) in a vacuum chamber. The shape of the target is determined by the design of the nozzle at the extrusion process. For the purpose, the choice is a rectangular shape with a width of 10 mm and a thickness in the range of 30-50 microns necessary for the physics objectives. The cryostat is equipped with a GM Cryocooler with sufficient power for the solidification of the hydrogen in the lower portion of the extruder. In the higher part of the cryostat, the hydrogen gas is first liquefied and partially solidified. It is then compressed at 100 bars in the cooled extruder before expulsion of the film through the nozzle at the center of the reaction vacuum chamber. After the previous step, the solid hydrogen ribbon falls by gravity into a dedicated chamber where it sublimes and the gas is pumped and evacuated in a exhaust line. This paper deals with the design of the cryostat with its equipment, with the sizing of the thermal bridge (Aluminum and copper), with the results regarding the contact resistance as well as with the vacuum computations of the reaction and recovery hydrogen gas chambers.

  11. Intradermal needle-free powdered drug injection

    E-Print Network [OSTI]

    Liu, John (John Hsiao-Yung)

    2012-01-01T23:59:59.000Z

    This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

  12. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01T23:59:59.000Z

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  13. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  14. NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM

    E-Print Network [OSTI]

    Hart, Steven N.

    2011-02-22T23:59:59.000Z

    Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

  15. Fabrication of boron sputter targets

    DOE Patents [OSTI]

    Makowiecki, Daniel M. (Livermore, CA); McKernan, Mark A. (Livermore, CA)

    1995-01-01T23:59:59.000Z

    A process for fabricating high density boron sputtering targets with sufficient mechanical strength to function reliably at typical magnetron sputtering power densities and at normal process parameters. The process involves the fabrication of a high density boron monolithe by hot isostatically compacting high purity (99.9%) boron powder, machining the boron monolithe into the final dimensions, and brazing the finished boron piece to a matching boron carbide (B.sub.4 C) piece, by placing aluminum foil there between and applying pressure and heat in a vacuum. An alternative is the application of aluminum metallization to the back of the boron monolithe by vacuum deposition. Also, a titanium based vacuum braze alloy can be used in place of the aluminum foil.

  16. Economic targeting in modern warfare

    SciTech Connect (OSTI)

    Lambeth, B.S.; Lewis, K.N.

    1982-07-01T23:59:59.000Z

    Nuclear weapons and strategies for their use play a variety of roles in the defense and foreign policies of the United States and Soviet Union. Accordingly, both nations buy forces and prepare war plans for many purposes. Although it is perhaps the least likely contingency for which either country prepares, the scenario in which both sides launch more or less all-out attacks against their opponent's economic or urban-industrial target system often dominates public consideration of strategic policy issues. These kinds of strikes, generically termed countervalue attacks, are usually assumed to throw many thousands of nuclear weapons against cities and isolated facilities in order to destroy the adversary nation as an organized, functioning, and economically viable entity.

  17. Peptide-and Aptamer-Functionalized Nanovectors for Targeted

    E-Print Network [OSTI]

    Kokkoli, Efie

    that higher doses of a tar- geted drug could be delivered to a patient as opposed to the free drug, therefore acid, antibodies, pro

  18. Independent Oversight Targeted Review, Y-12 National Security...

    Office of Environmental Management (EM)

    Targeted Review, Y-12 National Security Complex - February 2012 Independent Oversight Targeted Review, Y-12 National Security Complex - February 2012 February 2012 Targeted Review...

  19. Explanations of FreedomCAR/DOE Hydrogen Storage Technical Targets...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Explanations of FreedomCARDOE Hydrogen Storage Technical Targets Explanations of FreedomCARDOE Hydrogen Storage Technical Targets Summary of FreedomCAR Targets and Basis for...

  20. The study of downstream targets and other characteristics of NTT

    E-Print Network [OSTI]

    Fung, Michelle W.

    2009-01-01T23:59:59.000Z

    SAN DIEGO The Study of Downstream Targets and OtherOF THE THESIS The Study of Downstream Targets and Othera number of putative downstream targets of NTT, including

  1. Table I: Technical Targets for Catalyst Coated Membranes (CCMs...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    I: Technical Targets for Catalyst Coated Membranes (CCMs): Automotive Table I: Technical Targets for Catalyst Coated Membranes (CCMs): Automotive Technical targets for fuel cell...

  2. Efficiency in Quantum Key Distribution Protocols with Entangled Gaussian States

    E-Print Network [OSTI]

    C. Rodó; O. Romero-Isart; K. Eckert; A. Sanpera

    2007-03-21T23:59:59.000Z

    Quantum key distribution (QKD) refers to specific quantum strategies which permit the secure distribution of a secret key between two parties that wish to communicate secretly. Quantum cryptography has proven unconditionally secure in ideal scenarios and has been successfully implemented using quantum states with finite (discrete) as well as infinite (continuous) degrees of freedom. Here, we analyze the efficiency of QKD protocols that use as a resource entangled gaussian states and gaussian operations only. In this framework, it has already been shown that QKD is possible (M. Navascu\\'es et al. Phys. Rev. Lett. 94, 010502 (2005)) but the issue of its efficiency has not been considered. We propose a figure of merit (the efficiency $E$) to quantify the number of classical correlated bits that can be used to distill a key from a sample of $N$ entangled states. We relate the efficiency of the protocol to the entanglement and purity of the states shared between the parties.

  3. Field Test of Measurement-Device-Independent Quantum Key Distribution

    E-Print Network [OSTI]

    Yan-Lin Tang; Hua-Lei Yin; Si-Jing Chen; Yang Liu; Wei-Jun Zhang; Xiao Jiang; Lu Zhang; Jian Wang; Li-Xing You; Jian-Yu Guan; Dong-Xu Yang; Zhen Wang; Hao Liang; Zhen Zhang; Nan Zhou; Xiongfeng Ma; Teng-Yun Chen; Qiang Zhang; Jian-Wei Pan

    2014-08-11T23:59:59.000Z

    A main type of obstacles of practical applications of quantum key distribution (QKD) network is various attacks on detection. Measurement-device-independent QKD (MDIQKD) protocol is immune to all these attacks and thus a strong candidate for network security. Recently, several proof-of-principle demonstrations of MDIQKD have been performed. Although novel, those experiments are implemented in the laboratory with secure key rates less than 0.1 bps. Besides, they need manual calibration frequently to maintain the system performance. These aspects render these demonstrations far from practicability. Thus, justification is extremely crucial for practical deployment into the field environment. Here, by developing an automatic feedback MDIQKD system operated at a high clock rate, we perform a field test via deployed fiber network of 30 km total length, achieving a 16.9 bps secure key rate. The result lays the foundation for a global quantum network which can shield from all the detection-side attacks.

  4. Bacteria-targeting nanoparticles for managing infections

    E-Print Network [OSTI]

    Radovic-Moreno, Aleksandar Filip

    2013-01-01T23:59:59.000Z

    Bacterial infections continue to be a significant concern particularly in healthcare settings and in the developing world. Current challenges include the increasing spread of drug resistant (DR) organisms, the side effects ...

  5. POLYMER PROGRAM SEMINAR "Targeted polymeric nanoparticles

    E-Print Network [OSTI]

    Alpay, S. Pamir

    , IMS Room 20 A variety of organic and inorganic materials have been utilized to generate nanoparticles drugs for combination therapy. The surface engineering of these nanoparticles may yield them "stealth

  6. biocompatibility, stability, , p-p multi-drug

    E-Print Network [OSTI]

    Hong, Deog Ki

    , biocompatibility, stability, , p-p .2 Ø multi-drug resistance gene co- delivered photothermal , , . Ø , biocompatibility, stability, , p-p .2 Ø multi-drug resistance gene co graphene oxide-para amino benzoic acid nanosheet as effective drug delivery system to treat drug resistant

  7. Illegal Drugs Policy Swansea University and Students' Union

    E-Print Network [OSTI]

    Martin, Ralph R.

    Illegal Drugs Policy Swansea University and Students' Union #12;Illegal Drugs Policy for Swansea 2. Who is covered by the policy? 3. Aims of the policy 5. What do we mean by illegal drugs? 4 illegal drug use. · Take very seriously our legal duty of care to our students, staff and visitors and aim

  8. A Key to Common Caterpillar Pests of Vegetables 

    E-Print Network [OSTI]

    Sparks Jr., Alton N.; Liu, Tong-Xian

    2001-08-10T23:59:59.000Z

    of the head capsule. The proximity of the juncture of the adfrontal and epicranial sutures to the vertical triangle is used in separating armyworms and cutworms. Using the key The key will help you identify the most destructive and most com- mon caterpillar...; sp=spiracle Figure 3. Common arrangement of crochets on prolegs. A?complete circle B?semicircle C?two rows D?single row Figure 4. Head capsule of a caterpillar. vt=vertical triangle; epi=epicranial suture; adf=adfrontal suture 3 1 Body has numerous...

  9. BUSCH CAMPUS KEY PICK UP INSTRUCTIONS: ALL STUDENTS: ONLY YOU CAN PICK UP YOUR KEY. You will be required to present photo

    E-Print Network [OSTI]

    BUSCH CAMPUS KEY PICK UP INSTRUCTIONS: ALL STUDENTS: ONLY YOU CAN PICK UP YOUR KEY. You at the Housing and Residence Life Office, 581 Taylor Road, Busch Campus. If you are unable to pick up your key. _____________________________________________________________________________________ FIRST-YEAR STUDENTS MOVE-IN DAY KEY PICK UP BUSCH CAMPUS SATURDAY, AUGUST 28th 8:00 a.m. ­ 2:00 p

  10. Development of granular target for CADS

    E-Print Network [OSTI]

    McDonald, Kirk

    Exchanger 90K Max velocity of cold fluid 1.52m/s Wall Thickness of Heat Exchanger 1.75cm Flux of Gas inject Design goals: For CIADS, the target can accommodate 2.5MW=250MeV@10mA; the target system can update pipe can choose ~30-40 cm, then, the target would be design for >10MW. The heat removal of the window

  11. Moller Polarimetry with Atomic Hydrogen Targets

    SciTech Connect (OSTI)

    Chudakov, Eugene [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Luppov, V. [University of Michigan Spin Physics Center, Ann Arbor, MI (United States)

    2012-06-01T23:59:59.000Z

    A proposal to use polarized atomic hydrogen gas as the target for electron beam polarimetry based on the Moller scattering is described. Such a gas, stored in an ultra-cold magnetic trap, would provide a target of practically 100\\% polarized electrons. It is conceivable to reach a $\\sim$0.3\\% systematic accuracy of the beam polarimetry with such a target. Feasibility studies for the CEBAF electron beam have been performed.

  12. Tensor Target Polarization at TRIUMF

    SciTech Connect (OSTI)

    Smith, G

    2014-10-27T23:59:59.000Z

    The first measurements of tensor observables in $\\pi \\vec{d}$ scattering experiments were performed in the mid-80's at TRIUMF, and later at SIN/PSI. The full suite of tensor observables accessible in $\\pi \\vec{d}$ elastic scattering were measured: $T_{20}$, $T_{21}$, and $T_{22}$. The vector analyzing power $iT_{11}$ was also measured. These results led to a better understanding of the three-body theory used to describe this reaction. %Some measurements were also made in the absorption and breakup channels. A direct measurement of the target tensor polarization was also made independent of the usual NMR techniques by exploiting the (nearly) model-independent result for the tensor analyzing power at 90$^\\circ _{cm}$ in the $\\pi \\vec{d} \\rightarrow 2p$ reaction. This method was also used to check efforts to enhance the tensor polarization by RF burning of the NMR spectrum. A brief description of the methods developed to measure and analyze these experiments is provided.

  13. Thermal-hydraulic analysis of the LANL/IPPE/EDO-GP 1-MW LBE target

    SciTech Connect (OSTI)

    He, X.; Ammerman, C.; Woloshun, K.; Li, N.

    2000-07-01T23:59:59.000Z

    The accelerator-driven transmutation of waste (ATW) concept has been proposed by the United States and other countries to transmute plutonium, higher actinides, and other environmentally hazardous fission products. One of the key components in the ATW concept is a target that, via spallation, produces neutrons to transmute nuclear waste. Since significant heat is generated during fissioning of the waste actinides, an efficient heat removal system is necessary. Liquid lead-bismuth eutectic (LBE) is an efficient coolant as well as a good spallation target for production of neutrons. The LBE coolant technology has been successfully used in Russian submarine nuclear reactors. The International Science and Technology Center (ISTC) has funded the Institute of Physics and Power Engineering (IPPE) and the Experiment and Design Organization-Gidropress (EDO-GP) of Russia to design and manufacture a pilot target (Target Circuit One-TC1) that incorporates Russian LBE technology into the ATW concept. The target will be tested in the 800-MeV, 1-mA proton beam at the Los Alamos National Laboratory (LANL) in 2 yr. These target experiments will provide valuable information on the performance of LBE as both spallation target and coolant. They will also help to design target/blanket systems for future ATW facilities. In summary, the authors have carried out thermal-hydraulic analyses for the LANL/IPPE/EDO-GP 1-MW LBE target. It is shown that the current design is suitable for the beam-on tests. The diffuser plate successfully enhances the coolant flow around the window center but still avoids generating recirculation zone downstream. The temperature range is within the proper operation range for both the LBE coolant and the structural materials.

  14. Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing

    E-Print Network [OSTI]

    Gates, Kent. S.

    CHEM 4170 Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing assignment, this is a literature research project. The data for your drug will be presented below. Do not choose a drug that has been discussed in detail in Silverman's Book or in class. You may

  15. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  16. Automatic Drug-Drug Interaction Detection: A Machine Learning Approach With Maximal

    E-Print Network [OSTI]

    Rosso, Paolo

    Automatic Drug-Drug Interaction Detection: A Machine Learning Approach With Maximal Frequent-level and character-level have been proven to have a high discrim- inative power for detecting DDI, while pattern% precision and 84% recall. In [3] the authors propose a first approximation for DDI detection based

  17. Enterprise Assessments Targeted Review, Lawrence Livermore National...

    Broader source: Energy.gov (indexed) [DOE]

    February 2015 Targeted Review of the Safety-Class Room Ventilation Systems and Associated Final Filtration Stages, and Review of Federal Assurance Capability at the Lawrence...

  18. DOE Program/Targets and Workshop Objectives

    Broader source: Energy.gov (indexed) [DOE]

    Nancy Garland DOE Hydrogen Program Fuel Cell Operation at Sub- Freezing Temperatures DOE ProgramTargets and Workshop Objectives Sub-Freezing Temperature Effects on Fuel Cells...

  19. In 2010 a group of key forestry players

    E-Print Network [OSTI]

    Forestry Skills Action Plan #12;Summary #12;In 2010 a group of key forestry players came together to start a movement across the sector to upskill the current, and train the future, forestry workforce. #12;In May 2010 Forestry Commission England convened a small cross- sector task and finish group

  20. Key issues of FED/INTOR impurity control system

    SciTech Connect (OSTI)

    Abdou, M.A.

    1982-10-01T23:59:59.000Z

    A key part of the FED/INTOR activity over the past year has focused on examining the critical issues and developing credible physics and engineering solutions for the impurity control system. The primary emphasis of the work was on the edge-region physics, plasma-wall interaction, materials, engineering and magnetic considerations of the poloidal divertor and pump limiter.

  1. Public-Key Locally-Decodable Codes Brett Hemenway

    E-Print Network [OSTI]

    Ostrovsky, Rafail

    Semantically-Secure Public Key En- cryption (SS-PKE) and any Private Information Retrieval (PIR) protocol. Since Homomorphic encryption implies PIR, we also show a reduction from any Homomorphic encryption protocol to PKLDC. Applying our construction to the best known PIR protocol (that of Gentry and Ramzan), we

  2. The Key Coal Producers ONLINE SUPPORTING MATERIALS to

    E-Print Network [OSTI]

    Patzek, Tadeusz W.

    The Key Coal Producers ONLINE SUPPORTING MATERIALS to A Global Coal Production Forecast with Multi's most important coal-producing area is North-Central China. The provinces of Inner Mongolia, Ningxia, Shaanxi and Shanxi together accounted for 83 percent of China's proven coal reserves in 2000, and Shanxi

  3. Key Management with Policy-based Access Control Christian Cachin

    E-Print Network [OSTI]

    Cachin, Christian

    a crucial role for the security of network-based key management. Modern access-control systems are policy in policies. In this presentation we discuss how to integrate a policy-based access control system using XACMLKey Management with Policy-based Access Control Christian Cachin Divay Bansal G¨unter Karjoth 27

  4. Dictionaries Using Variable-Length Keys and Data, with Applications *

    E-Print Network [OSTI]

    Blelloch, Guy E.

    (Isil- logn, 1) + Itil) and Isil is the length of bit string si. We assume a word length w > log m. We present string Isil > 1, Itil > 1 for all bit-strings si and ti. Fox' fixed-length keys the dictionary problem

  5. The Seven Keys to Success in Energy Management and Conservation

    E-Print Network [OSTI]

    Darby, D. F.

    1984-01-01T23:59:59.000Z

    This paper is a summary of the seven key elements of the Deere & Company Energy Management and Conservation Program. These elements have been found to be essential for the ultimate success of any company-wide energy management program. The process...

  6. Efficient Algorithms for Implementing Elliptic Curve PublicKey Schemes

    E-Print Network [OSTI]

    Efficient Algorithms for Implementing Elliptic Curve Public­Key Schemes by Dan Beauregard A Thesis Cyganski Thesis Advisor Thesis Committee Dr. Stanley Selkow Dr. John Orr Thesis Committee Department Head #12; Preface This thesis describes the research which I conducted while completing my graduate work

  7. Termites, elephants and fire are key drivers of tree mortality

    E-Print Network [OSTI]

    mortality: 2 dominated by elephant damage, 2 by termite attack and 1 by fire. Wind and human activity wereTermites, elephants and fire are key drivers of tree mortality 5 plots suffered substantial tree not major causes of tree mortality. Sample sizes are too small to reasonably determine the most significant

  8. Daylight quantum key distribution over 1.6 km

    E-Print Network [OSTI]

    W. T. Buttler; R. J. Hughes; S. K. Lamoreaux; G. L. Morgan; J. E. Nordholt; C. G. Peterson

    2000-01-25T23:59:59.000Z

    Quantum key distribution (QKD) has been demonstrated over a point-to-point $\\sim1.6$-km atmospheric optical path in full daylight. This record transmission distance brings QKD a step closer to surface-to-satellite and other long-distance applications.

  9. Keys for growth in Japan's mature mobile market

    E-Print Network [OSTI]

    Oto, Hiroyuki

    2005-01-01T23:59:59.000Z

    The objective of this thesis is to identify key factors that will produce further growth for NTT DoCoMo in Japan's mature mobile market. Since the early 1990s, the mobile phone market in Japan has grown rapidly, and ...

  10. Highly Efficient Quantum Key Distribution Immune to All Detector Attacks

    E-Print Network [OSTI]

    Wen-Fei Cao; Yi-Zheng Zhen; Yu-Lin Zheng; Zeng-Bing Chen; Nai-Le Liu; Kai Chen; Jian-Wei Pan

    2014-10-10T23:59:59.000Z

    Vulnerabilities and imperfections of single-photon detectors have been shown to compromise security for quantum key distribution (QKD). The measurement-device-independent QKD (MDI-QKD) appears to be the most appealing solution to solve the issues. However, in practice one faces severe obstacles of having significantly lower key generation rate, difficult two photon interferences, and remote synchronization etc. In this letter, we propose a highly efficient and simple quantum key distribution scheme to remove all of these drawbacks. Our proposal can be implemented with only small modifications over the standard decoy BB84 system. Remarkably it enjoys both the advantages of high key generation rate (being almost two orders of magnitude higher than that based on conventional MDI-QKD) comparable to the normal decoy system, and security against any detector side channel attacks. Most favorably one can achieve complete Bell state measurements with resort to single photon interference, which reduces significantly experimental costs. Our approach enables utilization of high speed and efficient secure communication, particularly in real-life scenario of both metropolitan and intercity QKD network, with an attack free fashion from arbitrary detector side channels.

  11. Offshore Wind Power Experiences, Potential and Key Issues for

    E-Print Network [OSTI]

    offshore wind farms are installed in British, Swedish and Danish waters, and present-day costs in 2015, 2030 and 2050 14 3.1 Offshore wind farms under construction and in planning stage 14 3Offshore Wind Power Experiences, Potential and Key Issues for Deployment Jørgen Lemming, Poul Erik

  12. Combinatorial Design of Key Distribution Mechanisms for Wireless Sensor Networks

    E-Print Network [OSTI]

    Bystroff, Chris

    Combinatorial Design of Key Distribution Mechanisms for Wireless Sensor Networks Seyit A. C¸amtepe1 of the most challenging security issues in wireless sensor networks where sensor nodes are randomly scattered-chain sizes. 1 Introduction and Problem Definition In this work, we consider a sensor network in which sensor

  13. Combinatorial Design of Key Distribution Mechanisms for Wireless Sensor Networks

    E-Print Network [OSTI]

    Bystroff, Chris

    Combinatorial Design of Key Distribution Mechanisms for Wireless Sensor Networks Seyit A. C� amtepe of the most challenging security issues in wireless sensor networks where sensor nodes are randomly scattered­chain sizes. 1 Introduction and Problem Definition In this work, we consider a sensor network in which sensor

  14. Putting cancer in focusPathologists key to picking the

    E-Print Network [OSTI]

    Eichman, Brandt F.

    Putting cancer in focusPathologists key to picking the right path to a cure momentum IN THIS ISSUE without cancer. #12;EDITOR Heather Newman DESIGN Diana Duren DIRECTOR OF PUBLICATIONS Wayne Wood ASSOCIATE / Photo Researchers, Inc. EDITORIAL OFFICE Vanderbilt-Ingram Cancer Center 691 Preston Building Nashville

  15. Key Factors for Digital Collections August 7, 2007

    E-Print Network [OSTI]

    by Fondren's Digital Library Initiative We evaluate digital projects on a case by case basis. There is no oneKey Factors for Digital Collections August 7, 2007 Rice University Digital Repository Supported formula for this process and in fact welcome open discussion on potential digital projects

  16. Page 1 of 4 Creating and Submitting a Key Request

    E-Print Network [OSTI]

    Howitt, Ivan

    of employees. Enter search criteria in the search fields available and select the down red arrow to filter the terms. #12;Page 3 of 4 13. On the Key Request Form - Room List windowpane, select Add New. 14 use the Select Drawing button after entering the building and floor to display the floor plan

  17. Using Key Performance Indicators to Manage Energy Costs

    E-Print Network [OSTI]

    Van Gorp, J. C.

    2005-01-01T23:59:59.000Z

    -effective to collect much more data than ever before, many energy managers find themselves drowning in the volume of data generated. Business information systems faced a similar challenge a decade ago, and it is now common practice to use Key Performance Indicators...

  18. Architecture of the Secoqc Quantum Key Distribution network

    E-Print Network [OSTI]

    Mehrdad Dianati; Romain Alleaume

    2006-10-25T23:59:59.000Z

    The European projet Secoqc (Secure Communication based on Quantum Cryptography) aims at developing a global network for unconditionally secure key distribution. This paper specifies the requirements and presents the principles guiding the design of this network, and relevant to its architecture and protocols.

  19. Families First: Keys to Successful Family Functioning An Introduction

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    . publication 350-090 #12;KEY CHARACTERISTICS OF HEALTHY FAMILIES Research has identified several; and the aging family. Crisis tasks are family hardship events such as ill- ness, job loss, accidents, relocation Virginia Cooperative Extension programs and employment are open to all, regardless of race, color, national

  20. USB Key Profile Manager for Advisor: Dr. Chris Pollett

    E-Print Network [OSTI]

    Pollett, Chris

    . · Search for profiles. · Load the profile to Mozilla's registry. · Clean up at shutdown. #12;Feature 2USB Key Profile Manager for Mozilla by Yun Zhou Advisor: Dr. Chris Pollett Committee Members: Dr. Design and Implementation · Event-driven structure · USB profile loader · User authentication · Bulk

  1. The Design of a Group Key Agreement API Giuseppe Ateniese

    E-Print Network [OSTI]

    Kim, Dae-Shik

    and communication-independent API. The rest of this paper is organized as follows. We be- gin with the notationThe Design of a Group Key Agreement API Giuseppe Ateniese Computer Science Department Johns Hopkins describes a protocol suite and an API geared for securing collab- orative applications. The API is based

  2. Cryptanalysis of two knapsack public-key cryptosystems

    E-Print Network [OSTI]

    Han1 {jguobi,hanlidong}@sdu.edu.cn mengxm@sdfi.edu.cn 1 Key Laboratory of Cryptologic Technology is useless to the security of the cryptosystem. Because of the special super increasing structure, we can. We show that the permutation algorithm is useless to avoid the low-density attack and the density

  3. PEM FUEL CELL TECHNOLOGY Key Research Needs and Approaches

    E-Print Network [OSTI]

    Developer University #12;8 FUEL CELL RESEARCH NEEDS MEA optimization should focus on new materials Pt (full1 PEM FUEL CELL TECHNOLOGY Key Research Needs and Approaches Tom Jarvi UTC Power South Windsor, CT 06074 23 January 2008 #12;2 UTC POWER MARKET FOCUS Transportation Fuel Cells On-Site Power Solutions #12

  4. The U.S. ISO Key Project on Quasars

    E-Print Network [OSTI]

    Eric Hooper; Belinda Wilkes; Kim McLeod; Jonathan McDowell; Martin Elvis; Matthew Malkan; Carol Lonsdale; Chris Impey

    1998-09-22T23:59:59.000Z

    Observations for the U.S. key project on quasars using ISO were completed in April when the satellite's cryogen supply expired. This proceeding presents an update of the project, including information on the final sample, a discussion of some of the data reduction challenges and current efforts to meet them, plus a comparison of preliminary results with IRAS fluxes.

  5. absorption line key: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    absorption line key First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 The Hubble Space Telescope Quasar...

  6. On the Performance of Group Key Management Protocols in MANETs

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    . In this paper, we present an evaluation method for group key management protocols within ad hoc networks based the NS2 network simulator. To present our contribution, we structure this paper as follows. Section 22010 Author manuscript, published in "Joint Conference on Security in Network Architectures

  7. Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB

    SciTech Connect (OSTI)

    Chen, Wenjing; Biswas, Tapan; Porter, Vanessa R.; Tsodikov, Oleg V.; Garneau-Tsodikova, Sylvie (Michigan)

    2011-09-06T23:59:59.000Z

    The emergence of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis (TB) is a serious global threat. Aminoglycoside antibiotics are used as a last resort to treat XDR-TB. Resistance to the aminoglycoside kanamycin is a hallmark of XDR-TB. Here, we reveal the function and structure of the mycobacterial protein Eis responsible for resistance to kanamycin in a significant fraction of kanamycin-resistant Mycobacterium tuberculosis clinical isolates. We demonstrate that Eis has an unprecedented ability to acetylate multiple amines of many aminoglycosides. Structural and mutagenesis studies of Eis indicate that its acetylation mechanism is enabled by a complex tripartite fold that includes two general control non-derepressible 5 (GCN5)-related N-acetyltransferase regions. An intricate negatively charged substrate-binding pocket of Eis is a potential target of new antitubercular drugs expected to overcome aminoglycoside resistance.

  8. 7/6/12 Florida Blue Key Homecoming 1/8fbk.org/homecoming/

    E-Print Network [OSTI]

    Latchman, Haniph A.

    7/6/12 Florida Blue Key Homecoming 1/8fbk.org/homecoming/ Since 1923, Florida Blue Key has served in the fall, Homecoming and Gator Growl are produced by a team of over 500 students working in Florida Blue Blue Key on Facebo 430 people like Florida Blue Key Like Florida Blue Key via Growl & UF Homecoming

  9. Key-Insulated Signcryption (Science and Technology on Communication Security Laboratory,

    E-Print Network [OSTI]

    Zheng, Yuliang

    Key-Insulated Signcryption Jia Fan 1 (Science and Technology on Communication Security Laboratory addresses the issue of key exposure by proposing a key-insulated signcryption technique. We define a security model for key-insulated signcryption and prove that the key- insulated signcryption technique

  10. Design and Testing of a Prototype Spallation Neutron Source Rotating Target Assembly

    SciTech Connect (OSTI)

    Rennich, Mark J [ORNL; McManamy, Thomas J [ORNL; Graves, Van [Oak Ridge National Laboratory (ORNL); Garmendia, Amaia Zarraoa [IDOM Bilbao; Sorda, Fernando [ESS Bilbao

    2010-01-01T23:59:59.000Z

    The mechanical aspects of an extended vertical shaft rotating target have been evaluated in a full-scale mockup test. A prototype assembly based on a conceptual target design for a 1 to 3-MW spallation facility was built and tested. Key elements of the drive/coupling assembly implemented in the prototype include high integrity dynamic face seals, commercially available bearings, realistic manufacturing tolerances, effective monitoring and controls, and fail-safe shutdown features. A representative target disk suspended on a 3.5 meter prototypical shaft was coupled with the drive to complete the mechanical tests. After1800 hours of operation the test program has confirmed the overall mechanical feasibility of the extended vertical shaft rotating target concept. Precision alignment of the suspended target disk; successful containment of the water and verification of operational stability over the full speed range of 30 to 60 rpm were primary indications the proposed mechanical design is valid for use in a high power target station.

  11. Photodynamic Therapy of the Canine Prostate: Intra-arterial Drug Delivery

    SciTech Connect (OSTI)

    Moore, Ronald B. [University of Alberta, Department of Surgery (Canada)], E-mail: rmoore@cha.ab.ca; Xiao, Zhengwen [University of Alberta, Cross Cancer Institute, Department of Oncology (Canada); Owen, Richard J.; Ashforth, Robert [University of Alberta, Department of Radiology and Diagnostic Imaging (Canada); Dickey, Dwayne [University of Alberta, Department of Electric Engineering (Canada); Helps, Cathy [Cross Cancer Institute, Department of Nuclear Medicine and Oncologic Imaging (Canada); Tulip, John [University of Alberta, Department of Electric Engineering (Canada)

    2008-01-15T23:59:59.000Z

    Purpose. Interstitial photodynamic therapy (PDT) selectively destroys tissue targeted with a photosensitizer and then exposed to light of a specific wavelength. We report a novel delivery method-intra-arterial drug delivery for PDT of the prostate-in a canine model.Methods. To evaluate drug distribution, the prostatovesical artery was selectively cannulated and photosensitizers alone or in conjunction with 99m-technetium-labeled macro-aggregated albumin ({sup 99m}Tc-MAA) were injected via a 3 Fr microcatheter in 8 animals. One dog was followed for 3 months to determine tolerance and toxicity. The remaining animals were euthanized and imaged with whole-body single photon emission CT and gamma counting for radioactivity distribution. Photosensitizer distribution was further analyzed by fluorescence confocal microscopy and tissue chemical extraction. To evaluate PDT, the photosensitizer QLT0074 was infused in 3 animals followed by interstitial illumination with 690 nm laser light. Results. Intra-arterial infusion selectively delivered drugs to the prostate, with both radioactivity and photosensitizer levels significantly higher (up to 18 times) than in the surrounding organs (i.e., rectum). With unilateral injection of {sup 99m}Tc-MAA, only the injected half of the prostate showed activity whereas bilateral administration resulted in drug delivery to the entire prostate. PDT resulted in comprehensive damage to the prostate without severe complications or systemic toxicity. Conclusion. Injection of radiolabeled MAA into the prostatovesical artery results in distribution within the prostate with negligible amounts reaching the adjacent organs. PDT also demonstrates selective damage to the prostate, which warrants clinical application in targeted prostate therapies.

  12. Multimodality Imaging with Silica-Based Targeted Nanoparticle Platforms

    SciTech Connect (OSTI)

    Jason S. Lewis

    2012-04-09T23:59:59.000Z

    Objectives: To synthesize and characterize a C-Dot silica-based nanoparticle containing 'clickable' groups for the subsequent attachment of targeting moieties (e.g., peptides) and multiple contrast agents (e.g., radionuclides with high specific activity) [1,2]. These new constructs will be tested in suitable tumor models in vitro and in vivo to ensure maintenance of target-specificity and high specific activity. Methods: Cy5 dye molecules are cross-linked to a silica precursor which is reacted to form a dye-rich core particle. This core is then encapsulated in a layer of pure silica to create the core-shell C-Dot (Figure 1) [2]. A 'click' chemistry approach has been used to functionalize the silica shell with radionuclides conferring high contrast and specific activity (e.g. 64Cu and 89Zr) and peptides for tumor targeting (e.g. cRGD and octreotate) [3]. Based on the selective Diels-Alder reaction between tetrazine and norbornene, the reaction is bioorthogonal, highyielding, rapid, and water-compatible. This radiolabeling approach has already been employed successfully with both short peptides (e.g. octreotate) and antibodies (e.g. trastuzumab) as model systems for the ultimate labeling of the nanoparticles [1]. Results: PEGylated C-Dots with a Cy5 core and labeled with tetrazine have been synthesized (d = 55 nm, zeta potential = -3 mV) reliably and reproducibly and have been shown to be stable under physiological conditions for up to 1 month. Characterization of the nanoparticles revealed that the immobilized Cy5 dye within the C-Dots exhibited fluorescence intensities over twice that of the fluorophore alone. The nanoparticles were successfully radiolabeled with Cu-64. Efforts toward the conjugation of targeting peptides (e.g. cRGD) are underway. In vitro stability, specificity, and uptake studies as well as in vivo imaging and biodistribution investigations will be presented. Conclusions: C-Dot silica-based nanoparticles offer a robust, versatile, and multi-functional platform to enhance in vivo detection sensitivity and non-invasively assay receptor expression/status of tumor cellular targets, including those of low abundance, using nuclear-NIR fluorescence imaging approaches [2]. Improvements in molecular diagnostics, refined by the availability of nanotechnology platforms, will be a key determinant in driving early-stage disease detection and prevention, ultimately leading to decreases in mortality.

  13. Protein-Based Nanomedicine Platforms for Drug Delivery

    SciTech Connect (OSTI)

    Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

    2009-08-03T23:59:59.000Z

    Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drug’s efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

  14. A method for comparing impacts with real targets to impacts onto the IAEA unyielding target

    SciTech Connect (OSTI)

    Ammerman, D. J.

    1991-01-01T23:59:59.000Z

    The severity of the IAEA accident conditions test requirement (IAEA 1990) of an impact onto an essentially unyielding target from a drop height of 9 meters encompasses a large fraction of all real world impacts. This is true, in part, because of the unyielding nature of the impact target. Impacts onto the unyielding target have severities equivalent to higher velocity impacts onto real targets which are not unyielding. The severity of impacts with yielding targets is decreased by the amount of the impact energy absorbed in damaging the target. In demonstrating the severity of the regulatory impact event it is advantageous to be able to relate this impact onto an essentially unyielding target to impacts with yielding targets.

  15. Radioactive Target Detection Using Wireless Sensor Network

    E-Print Network [OSTI]

    Zhang, Tonglin

    Chapter 31 Radioactive Target Detection Using Wireless Sensor Network Tonglin Zhang Abstract for wireless sensor network data to detect and locate a hidden nuclear target in a large study area. The method assumes multiple radiation detectors have been used as sensor nodes in a wireless sensor network

  16. TechnicalDesign Report, Second Target Station

    SciTech Connect (OSTI)

    Galambos, John D [ORNL; Anderson, David E [ORNL; Bechtol, D [HDR, Inc.; Bethea, Katie L [ORNL; Brown, N [Barge Waggoner Sumner & Cannon, Inc.; Carden, W. F. [Oak Ridge National Laboratory (ORNL); Chae, Steven M [ORNL; Clark, A. [Barge Waggoner Sumner & Cannon, Inc.; Counce, Deborah M [ORNL; Craft, K [Barge Waggoner Sumner & Cannon, Inc.; Crofford, Mark T [ORNL; Collins, Richard M [ORNL; Cousineau, Sarah M [ORNL; Curry, Douglas E [ORNL; Cutler, Roy I [ORNL; Dayton, Michael J [ORNL; Dean, Robert A [ORNL; Deibele, Craig E [ORNL; Doleans, Marc [ORNL; Dye, T. [HDR, Inc.; Eason, Bob H [ORNL; Eckroth, James A [ORNL; Fincrock, C [HDR, Inc.; Fritts, S. [Barge Waggoner Sumner & Cannon, Inc.; Gallmeier, Franz X [ORNL; Gawne, Ken R [ORNL; Hartman, Steven M [ORNL; Herwig, Kenneth W [ORNL; Hess, S. [HDR, Inc.; Holmes, Jeffrey A [ORNL; Horak, Charlie M [ORNL; Howell, Matthew P [ORNL; Iverson, Erik B [ORNL; Jacobs, Lorelei L [ORNL; Jones, Larry C [ORNL; Johnson, B. [HDR, Inc.; Johnson, S. [HDR, Inc.; Kasemir, Kay [ORNL; Kim, Sang-Ho [ORNL; Laughon, Gregory J [ORNL; Lu, W. [Oak Ridge National Laboratory (ORNL); Mahoney, Kelly L [ORNL; Mammosser, John [ORNL; McManamy, T. [McManamy Consulting, Inc.; Michilini, M. [HDR, Inc.; Middendorf, Mark E [ORNL; O'Neal, Ed [Oak Ridge National Laboratory (ORNL); Nemec, B. [Barge Waggoner Sumner & Cannon, Inc.; Peters, Roy Cecil [ORNL; Plum, Michael A [ORNL; Reagan, G. [Barge Waggoner Sumner & Cannon, Inc.; Remec, Igor [ORNL; Rennich, Mark J [ORNL; Riemer, Bernie [ORNL; Saethre, Robert B [ORNL; Schubert, James Phillip [ORNL; Shishlo, Andrei P [ORNL; Smith, C Craig [ORNL; Strong, William Herb [ORNL; Tallant, Kathie M [ORNL; Tennant, David Alan [ORNL; Thibadeau, Barbara M [ORNL; Trumble, S. [HDR, Inc.; Trotter, Steven M [ORNL; Wang, Z. [Institute of Modern Physics (IMP), Chinese Academy of Sciences; Webb, Steven B [ORNL; Williams, Derrick C [ORNL; White, Karen S [ORNL; Zhao, Jinkui [ORNL

    2015-01-01T23:59:59.000Z

    The Second Target Station (STS) is a proposed upgrade for SNS. It includes a doubling of the accelerator power and an additional instrument hall. The new instrument hall will recieve a 467 kW 10 Hz beam. The parameters and preliminary design aspects of the STS are presented for the accelerator, target systems, instrument hall, instruments and civil construction aspects.

  17. THE ROTATING TARGET FLOW TEST FACILITY

    E-Print Network [OSTI]

    McDonald, Kirk

    @idom.com) Fernando Sordo, ESS Bilbao Tom McManamy, ORNL/SNS #12;Status of the RTFT 4th HPTW of a RotaAng Target for ESS · In 2009 ESS Bilbao worked out a preliminary design for a rotaZng target for ESS. · Disc formed by un-clad tungsten bricks cooled

  18. Dissecting Apicoplast Targeting in the Malaria Parasite

    E-Print Network [OSTI]

    McFadden, Geoff

    and are only poorly understood. We extracted amino acid features from transit peptides that target proteins to the relict plastid (apicoplast) of malaria parasites. Based on these amino acid characteristics, we to be important for correct targeting. Plastid transit peptides mediate accurate tar- geting of many hundreds

  19. Federal Student Aid Penalties for Drug Convictions Students convicted of a federal or state offense or possessing illegal drugs that occurred while they were

    E-Print Network [OSTI]

    Sadeh, Norman M.

    offense or possessing illegal drugs that occurred while they were receiving federal student aid should convictions for conspiring to sell drugs.) Possession of Sale of illegal Illegal drugs drugs 1st offense 1

  20. Delayed neutrons measurement at the MEGAPIE target

    E-Print Network [OSTI]

    Stefano Panebianco; Pavel Bokov; Diane Dore; Xavier Ledoux; Alain Letourneau; Aurelien Prevost; Danas Ridikas

    2007-05-25T23:59:59.000Z

    In the framework of the Neutronic and Nuclear Assessment Task Group of the MEGAPIE experiment we measured the delayed neutron (DN) flux at the top of the target. The measurement was proposed mainly for radioprotection purposes since the DN flux at the top of the target has been estimated to be of the same order of magnitude as the prompt neutron flux. Given the strong model-dependence of DN predictions, the measurement of DN contribution to the total neutron activity at the top of the target was thus desired. Moreover, this measurement is complementary to the DN experiments performed at PNPI (Gatchina) on solid lead and bismuth targets. The DN measurement at MEGAPIE was performed during the start-up phase of the target. In this paper we present a detailed description of the experimental setup and some preliminary results on decay spectra.