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1

Active constraint regions for a natural gas liquefaction process Magnus G. Jacobsen a  

E-Print Network [OSTI]

processes. 2. Optimal operation of a PRICO liquefaction plant 2.1. Plant description The PRICO processActive constraint regions for a natural gas liquefaction process Magnus G. Jacobsen a , Sigurd Keywords: Self-optimizing control Liquefied natural gas LNG PRICO Disturbances Optimal operation a b s t r

Skogestad, Sigurd

2

Doug Jacobsen  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to UserProduct:Directives Templates8. U.S.Donald R. BaerBaxterDoug

3

In Proc. SPIE 4013-55, UV, Optical, and IR Space Telescopes and Instruments VI, Breckinridge & Jacobsen, eds., Munich, Germany, March 2000. Resolving Piston Ambiguities when Phasing a Segmented Mirror  

E-Print Network [OSTI]

& Jacobsen, eds., Munich, Germany, March 2000. Resolving Piston Ambiguities when Phasing a Segmented Mirror light is insensitive to segment piston errors that are a whole number of waves. If the wavefront sensing range of a wavefront sensor can be extended from on the order of ¢¡¤£ 2 in piston to several waves

Löfdahl, Mats

4

Douglas Jacobsen! NERSC User Services  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phasesDataTranslocationDiurnal CycleDonald RabyMonitoring andRunning

5

Chris Jacobsen | Argonne National Laboratory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed New Substation SitesStandingtheirCheck InChemistryChris Benmore Argonne

6

Abene, Cathy 6-3547 Energy Donatucci, Dana 4-8507 Waste Svcs/Recycling (363-6145) Jach, Dan 6-8579 U Construction (221-4269) Allen, John 5-6311 Haz-Mat (799-0712) Drews, Paul 6-0493 East Bank (290-2672) Jacobsen, Brad 5-2378 Energy  

E-Print Network [OSTI]

Abene, Cathy 6-3547 Energy Donatucci, Dana 4-8507 Waste Svcs/Recycling (363-6145) Jach, Dan 6-2692) Kluge, Nick 6-7176 Waste Svcs/Recy Berkowitz, Wendy 4-8886 Finance/Accounting Ford, Robert 5-5527 Energy-2672) Jacobsen, Brad 5-2378 Energy Anderson, Conrad 5-0689 StP/W (HellerH) (328-1586) Durushia, Ann 6-0291 U Svcs

Gulliver, Robert

7

Douglas Jacobsen! NERSC Bioinformatics Computing Consultant  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phasesDataTranslocationDiurnal CycleDonald RabyMonitoring and Debugging

8

Douglas Jacobsen! NERSC Bioinformatics Computing Consultant  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phasesDataTranslocationDiurnal CycleDonald RabyMonitoring and

9

Douglas Jacobsen! NERSC Bioinformatics Computing Consultant  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phasesDataTranslocationDiurnal CycleDonald RabyMonitoring andRunning Jobs

10

Douglas Jacobsen! NERSC User Services Group  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phasesDataTranslocationDiurnal CycleDonald RabyMonitoring

11

arne jacobsens ideas: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

combines a kinetic Monte Carlo simulation for the thermal surface diffusion with a small scale molecular-dynamics simulation of every single deposition Sethna, James P. 23...

12

Douglas Jacobsen, Yushu Yao! NERSC User Services Group  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phasesDataTranslocationDiurnal CycleDonald RabyMonitoringSeptember 10,

13

Douglas Jacobsen, Yushu Yao! NERSC User Services Group  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phasesDataTranslocationDiurnal CycleDonald RabyMonitoringSeptember 10,

14

Douglas Jacobsen, Yushu Yao! NERSC User Services Group  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phasesDataTranslocationDiurnal CycleDonald RabyMonitoringSeptember

15

Jacobsen of XSD Elected to American Physical Society Fellowship  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on the followingLearningJackJacobChapman of

16

Trichoderma genes  

DOE Patents [OSTI]

Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabionfuranosidase and one encoding an acetylxylanesterase are described. The sequences, CIP1 and CIP2, contain a cellulose binding domain. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.

Foreman, Pamela (Los Altos, CA); Goedegebuur, Frits (Vlaardingen, NL); Van Solingen, Pieter (Naaldwijk, NL); Ward, Michael (San Francisco, CA)

2012-06-19T23:59:59.000Z

17

Microfluidic gene synthesis  

E-Print Network [OSTI]

The ability to synthesize custom de novo DNA constructs rapidly, accurately, and inexpensively is highly desired by researchers, as synthetic genes and longer DNA constructs are enabling to numerous powerful applications ...

Kong, David Sun, 1979-

2008-01-01T23:59:59.000Z

18

Nonviral Vectors for Gene Delivery  

E-Print Network [OSTI]

optimized for gene delivery by varying particle surface chemistry using different coating materials that adsorb to the particle surface during formation. A variety of cationic coating materials were studied and compared to more conventional surfactants used...

Baoum, Abdulgader Ahmed

2011-04-26T23:59:59.000Z

19

Metazoan Gene Families from Metazome  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

Metazome is a joint project of the Department of Energy's Joint Genome Institute and the Center for Integrative Genomics to facilitate comparative genomic studies amongst metazoans. Clusters of orthologous and paralogous genes that represent the modern descendents of ancestral gene sets are constructed at key phylogenetic nodes. These clusters allow easy access to clade specific orthology/paralogy relationships as well as clade specific genes and gene expansions. As of version 2.0.4, Metazome provides access to twenty-four sequenced and annotated metazoan genomes, clustered at nine evolutionarily significant nodes. Where possible, each gene has been annotated with PFAM, KOG, KEGG, and PANTHER assignments, and publicly available annotations from RefSeq, UniProt, Ensembl, and JGI are hyper-linked and searchable. The included organisms (by common name) are: Human, Mouse, Rat, Dog, Opossum, Chicken, Frog, Stickleback, Medaka, Fugu pufferfish; Zebrafish, Seasquirt - savignyi, Seasquirt - intestinalis, Amphioxus, Sea Urchin, Fruitfly, Mosquite, Yellow Fever Mosquito, Silkworm, Red Flour Beetle, Worm, Briggsae Worm, Owl limpet (snail), and Sea anemone. [Copied from Metazome Overview at http://www.metazome.net/Metazome_info.php

20

Mining Virulence Genes Using Metagenomics  

E-Print Network [OSTI]

When a bacterial genome is compared to the metagenome of an environment it inhabits, most genes recruit at high sequence identity. In free-living bacteria (for instance marine bacteria compared against the ocean metagenome) certain genomic regions are totally absent in recruitment plots, representing therefore genes unique to individual bacterial isolates. We show that these Metagenomic Islands (MIs) are also visible in bacteria living in human hosts when their genomes are compared to sequences from the human microbiome, despite the compartmentalized structure of human-related environments such as the gut. From an applied point of view, MIs of human pathogens (e.g. those identified in enterohaemorragic Escherichia coli against the gut metagenome or in pathogenic Neisseria meningitidis against the oral metagenome) include virulence genes that appear to be absent in related strains or species present in the microbiome of healthy individuals. We propose that this strategy (i.e. recruitment analysis of pathogenic bacteria against the metagenome of healthy subjects) can be used to detect pathogenicity regions in species where the genes involved in virulence are poorly characterized. Using this approach, we detect well-known pathogenicity islands and identify new potential virulence genes in several human pathogens.

Pedro Belda-ferre; Ral Cabrera-rubio; Andrs Moya; Alex Mira

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Gene encoding plant asparagine synthetase  

DOE Patents [OSTI]

The identification and cloning of the gene(s) for plant asparagine synthetase (AS), an important enzyme involved in the formation of asparagine, a major nitrogen transport compound of higher plants is described. Expression vectors constructed with the AS coding sequence may be utilized to produce plant AS; to engineer herbicide resistant plants, salt/drought tolerant plants or pathogen resistant plants; as a dominant selectable marker; or to select for novel herbicides or compounds useful as agents that synchronize plant cells in culture. The promoter for plant AS, which directs high levels of gene expression and is induced in an organ specific manner and by darkness, is also described. The AS promoter may be used to direct the expression of heterologous coding sequences in appropriate hosts.

Coruzzi, Gloria M. (New York, NY); Tsai, Fong-Ying (New York, NY)

1993-10-26T23:59:59.000Z

22

GenePRIMP: Improving Microbial Gene Prediction Quality  

SciTech Connect (OSTI)

Amrita Pati of the DOE Joint Genome Institute's Genome Biology group talks about a computational pipeline that evaluates the accuracy of gene models in genomes and metagenomes at different stages of finishing at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

Pati, Amrita [DOE Joint Genome Institute's Genome Biology group

2009-05-29T23:59:59.000Z

23

ancestral gene relationships: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

thought previously of entire genomes, rather than individual genes, on the basis of the analysis of gene orders. Human, mouse Batzoglou, Serafim 17 Analyzing gene relationships...

24

ascl1 target genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for postgenomic analysis of mammalian gene function is gene targeting McConnell, Susan 2 Infrared lasermediated gene induction in targeted Chemistry Websites Summary: a heat shock...

25

abolishes gene targeting: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for postgenomic analysis of mammalian gene function is gene targeting McConnell, Susan 2 Infrared lasermediated gene induction in targeted Chemistry Websites Summary: a heat shock...

26

Enhanced polymeric nanoparticles for gene delivery  

E-Print Network [OSTI]

The potential of gene therapy to treat disease and improve human health is tremendous. The failure of viral gene therapy clinical trials due to toxicity, immunogenicity, and carcinogenicity has been tragic and strongly ...

Green, Jordan Jamieson

2007-01-01T23:59:59.000Z

27

Plant nitrogen regulatory P-PII genes  

DOE Patents [OSTI]

The present invention generally relates to plant nitrogen regulatory PII gene (hereinafter P-PII gene), a gene involved in regulating plant nitrogen metabolism. The invention provides P-PII nucleotide sequences, expression constructs comprising said nucleotide sequences, and host cells and plants having said constructs and, optionally expressing the P-PII gene from said constructs. The invention also provides substantially pure P-PII proteins. The P-PII nucleotide sequences and constructs of the

Coruzzi, Gloria M. (New York, NY); Lam, Hon-Ming (Hong Kong, HK); Hsieh, Ming-Hsiun (Woodside, NY)

2001-01-01T23:59:59.000Z

28

Regulation of the genes involved in nitrification.  

SciTech Connect (OSTI)

OAK-B135 This project focuses on the characterization of the regulation of the genes involved in nitrification in the bacterium Nitrosomonas europaea. The key genes in the nitrification pathway, amo and hao, are present in multiple copies in the genome. The promoters for these genes were identified and characterized. It was shown that there were some differences in the transcriptional regulation of the copies of these genes.

Arp, D.J.; Sayavedra-Soto, L.A.

2003-08-14T23:59:59.000Z

29

Uses of antimicrobial genes from microbial genome  

DOE Patents [OSTI]

We describe a method for mining microbial genomes to discover antimicrobial genes and proteins having broad spectrum of activity. Also described are antimicrobial genes and their expression products from various microbial genomes that were found using this method. The products of such genes can be used as antimicrobial agents or as tools for molecular biology.

Sorek, Rotem; Rubin, Edward M.

2013-08-20T23:59:59.000Z

30

Short Specialist Review Gene structure prediction  

E-Print Network [OSTI]

Short Specialist Review Gene structure prediction in plant genomes Volker Brendel Iowa State) within most genes makes the problem of computational gene structure prediction distinct from (and harder prediction in vertebrates. The second reason is pragmatic. Expressed Sequence Tag (EST) sequencing and whole

Brendel, Volker

31

Magnetotactic Bacteria: A Study of Mam Genes and Metabolism  

E-Print Network [OSTI]

, lacks several hemerythrin genes that might represent a gene island that harbors genes that encode hemerythrin island causes the non-magnetic phenotype or if deletion of magnetosome genes is involved as well

Walker, Lawrence R.

32

Inferring Gene Family Histories in Yeast Identifies Lineage Specific Expansions  

E-Print Network [OSTI]

The complement of genes found in the genome is a balance between gene gain and gene loss. Knowledge of the specific genes that are gained and lost over evolutionary time allows an understanding of the evolution of biological ...

Ames, Ryan M.; Money, Daniel; Lovell, Simon C.

2014-06-12T23:59:59.000Z

33

Method for determining gene knockouts  

DOE Patents [OSTI]

A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.

Maranas, Costas D. (Port Matilda, PA); Burgard, Anthony R. (State College, PA); Pharkya, Priti (State College, PA)

2011-09-27T23:59:59.000Z

34

Method for determining gene knockouts  

DOE Patents [OSTI]

A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.

Maranas, Costa D; Burgard, Anthony R; Pharkya, Priti

2013-06-04T23:59:59.000Z

35

Thermostable cellulase from a thermomonospora gene  

DOE Patents [OSTI]

The invention relates to a gene isolated from Thermomonospora fusca, wherein the gene encodes a thermostable cellulase. Disclosed is the nucleotide sequence of the T. fusca gene; and nucleic acid molecules comprising the gene, or a fragment of the gene, that can be used to recombinantly express the cellulase or a catalytically active polypeptide thereof, respectively. The isolated and purified recombinant cellulase or catalytically active polypeptide may be used to hydrolyze substrate either by itself; or in combination with other cellulases, with the resultant combination having unexpected hydrolytic activity. 3 figs.

Wilson, D.B.; Walker, L.P.; Zhang, S.

1997-10-14T23:59:59.000Z

36

Apolipoprotein gene involved in lipid metabolism  

DOE Patents [OSTI]

Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

Rubin, Edward (Berkeley, CA); Pennacchio, Len A. (Sebastopol, CA)

2007-07-03T23:59:59.000Z

37

Bacterial genes for stress | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone6 M. Babzien, I. Ben-Zvi, P. Study ofJ U LY 2 9Bacterial genes

38

Cross-Ontological Analytics: Combining Associative and Hierarchical Relations in the Gene Ontologies to Assess Gene Product Similarity  

SciTech Connect (OSTI)

Gene and gene product similarity is a fundamental diagnostic measure in analyzing biological data and constructing predictive models for functional genomics. With the rising influence of the gene ontologies, two complementary approaches have emerged where the similarity between two genes/gene products is obtained by comparing gene ontology (GO) annotations associated with the gene/gene products. One approach captures GO-based similarity in terms of hierarchical relations within each gene ontology. The other approach identifies GO-based similarity in terms of associative relations across the three gene ontologies. We propose a novel methodology where the two approaches can be merged with ensuing benefits in coverage and accuracy.

Posse, Christian; Sanfilippo, Antonio P.; Gopalan, Banu; Riensche, Roderick M.; Beagley, Nathaniel; Baddeley, Bob L.

2006-05-28T23:59:59.000Z

39

Characterization and expression of histone deacetylase 1 (athd1) in Arabidopsis thaliana  

E-Print Network [OSTI]

...........................................................................................................................95 ix LIST OF FIGURES Page Figure 2.1 The construct of AtHD1-GFP chimeric gene ........................... 19 Figure 2.2 Localization of AtHD1-GFP fusion protein in onion cells... (Kankel et al., 2003). Second, DRM1 5 (Domain-Rearranged Methyltransferase 1) and DRM2, which are similar to the mammalian DNMT3 family of methyltransferases, were identified as de novo methyltransferases in genome defense (Cao and Jacobsen, 2002a...

Fong, Man Kim

2005-08-29T23:59:59.000Z

40

Methods for monitoring multiple gene expression  

DOE Patents [OSTI]

The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.

Berka, Randy; Bachkirova, Elena; Rey, Michael

2013-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Methods for monitoring multiple gene expression  

SciTech Connect (OSTI)

The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.

Berka, Randy (Davis, CA); Bachkirova, Elena (Davis, CA); Rey, Michael (Davis, CA)

2012-05-01T23:59:59.000Z

42

A fruit quality gene map of Prunus  

E-Print Network [OSTI]

Central Open Access A fruit quality gene map of PrunusAbstract Background: Prunus fruit development, growth,and maintaining stone fruit quality from production and

Ogundiwin, Ebenezer A; Peace, Cameron P; Gradziel, Thomas M; Parfitt, Dan E; Bliss, Fredrick A; Crisosto, Carlos H

2009-01-01T23:59:59.000Z

43

GeneFarm, structural and functional annotation of Arabidopsis gene and protein families by a network  

E-Print Network [OSTI]

, and more secure planning and design of experiments. The purpose of the GeneFarmprojectis to obtain

Gent, Universiteit

44

Nucleotide Frequency Variation Across Human Genes  

E-Print Network [OSTI]

Nucleotide Frequency Variation Across Human Genes Elizabeth Louie, Jurg Ott, and Jacek Majewski1 The Rockefeller University, New York, New York 10021, USA The frequencies of individual nucleotides exhibit significant fluctuations across eukaryotic genes. In this paper, we investigate nucleotide variation across

Majewski, Jacek

45

Gene coding for the E1 endoglucanase  

DOE Patents [OSTI]

The gene encoding Acidothermus cellulolyticus E1 endoglucanase is cloned and expressed in heterologous microorganisms. A new modified E1 endoglucanase enzyme is produced along with variants of the gene and enzyme. The E1 endoglucanase is useful for hydrolyzing cellulose to sugars for simultaneous or later fermentation into alcohol. 6 figs.

Thomas, S.R.; Laymon, R.A.; Himmel, M.E.

1996-07-16T23:59:59.000Z

46

Tissue-Specific Gene Delivery via Nanoparticle Coating  

E-Print Network [OSTI]

The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

Harris, Todd J.

47

Tissue-specific gene silencing monitored in circulating RNA  

E-Print Network [OSTI]

Pharmacologic target gene modulation is the primary objective for RNA antagonist strategies and gene therapy. Here we show that mRNAs encoding tissue-specific gene transcripts can be detected in biological fluids and that ...

Sehgal, Alfica

48

Effects of Pinealectomy on Hypothalamic Metabolic and Clock Gene Rhythms  

E-Print Network [OSTI]

by comparing the affects of pinealectomy on 2DG uptake and canonical "clock" gene expression in the hypothalamus of house sparrows, Passer domesticus. Since other brain structures exhibit metabolic and clock gene rhythms, investigation of clock gene expression...

Clauson, Amanda

2006-07-11T23:59:59.000Z

49

Comparative gene identification in mammalian, fly, and fungal genomes  

E-Print Network [OSTI]

An important step in genome interpretation is the accurate identification of protein-coding genes. One approach to gene identification is comparative analysis of the genomes of several related species, to find genes that ...

Lin, Michael F. (Michael Fong-Jay)

2006-01-01T23:59:59.000Z

50

angiotensin receptor gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

36 The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia CiteSeer Summary: Dyslexia, or specific reading disability, is the most common...

51

arthritis candidate genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

37 The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia CiteSeer Summary: Dyslexia, or specific reading disability, is the most common...

52

albumin gene expression: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

biology, and multiple orthogonal gene switches are needed Zhao, Huimin 223 Metabolic load and heterologous gene expression CiteSeer Summary: The expression of a foreign...

53

Coregulation of terpenoid pathway genes and prediction of isoprene...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Coregulation of terpenoid pathway genes and prediction of isoprene production in Bacillus subtilis using transcriptomics. Coregulation of terpenoid pathway genes and prediction of...

54

Organization and evolution of the rat tyrosine hydroxylase gene  

SciTech Connect (OSTI)

This report describes the organization of the rat tyrosine hydroxylase (TH) gene and compares its structure with the human phenylalanine hydroxylase gene. Both genes are single copy and contain 13 exons separated by 12 introns. Remarkably, the positions of 10 out 12 intron/exon boundaries are identical for the two genes. These results support the idea that these hydroxylases genes are members of a gene family which has a common evolutionary origin. The authors predict that this ancestral gene would have encoded exons similar to those of TH prior to evolutionary drift to other members of this gene family.

Brown, E.R.; Coker, G.T. III; O'Malley, K.L.

1987-08-11T23:59:59.000Z

55

apoptosis related gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of protein Barkai, Naama 10 Inference of Gene Relations from Microarray Data by Abduction Computer Technologies and Information Sciences Websites Summary: Inference of Gene...

56

apoptosis related genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of protein Barkai, Naama 10 Inference of Gene Relations from Microarray Data by Abduction Computer Technologies and Information Sciences Websites Summary: Inference of Gene...

57

BESC Submits 32 Gene Disclosures for Patents | ORNL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

differences between normal and tension wood and identified 10 genes that appear to affect cellulose deposition. These genes are being overexpressed or underexpressed in poplar...

58

agnostic gene coding: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

25 Next Page Last Page Topic Index 21 Associating Genes with Gene Ontology Codes Using a Maximum Entropy Analysis of Biology and Medicine Websites Summary: and select appropriate...

59

Dynamics Modelling of Biolistic Gene Guns  

SciTech Connect (OSTI)

The gene transfer process using biolistic gene guns is a highly dynamic process. To achieve good performance, the process needs to be well understood and controlled. Unfortunately, no dynamic model is available in the open literature for analysing and controlling the process. This paper proposes such a model. Relationships of the penetration depth with the helium pressure, the penetration depth with the acceleration distance, and the penetration depth with the micro-carrier radius are presented. Simulations have also been conducted. The results agree well with experimental results in the open literature. The contribution of this paper includes a dynamic model for improving and manipulating performance of the biolistic gene gun.

Zhang, M.; Tao, W.; Pianetta, P.A.

2009-06-04T23:59:59.000Z

60

Nonlinear effects in kinetic resolutions  

E-Print Network [OSTI]

KTRIC AMPLIFICATION IN THE JACOBSEN HYDROLYTIC KINET RESOLUTION OF RACEMIC EPOXIDES 20 Applicability of Homocompetitive Reaction Kinetics to the Jacobsen HKR Effect of Catalyst EE and Choice of Epoxide on Amplification in the Jacobsen HKR.... . . . . . . . . . . . . . . . . . Effect of Temperature on Amplification and Reaction Rate in the Jacobsen HKR . Effect of Low EE Catalyst Generation on Amplification in the Jacobsen HKR. . . . 21 21 25 26 27 30 31 TABLE OF CONTENTS (Continued) CHAPTER Page V AS...

Johnson, Derrell W.

1999-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Horizontal gene transfer in Bacteroides fragilis  

E-Print Network [OSTI]

Horizontal gene transfer (HGT) is one of the man driving forces of evolution in prokaryotes, and can also promote within-strain variation of bacterial species. The genomes of three previously sequenced Bacteroides fragilis ...

Jobling, Kelly Louise

2014-11-27T23:59:59.000Z

62

Predicting gene function from images of cells  

E-Print Network [OSTI]

This dissertation shows that biologically meaningful predictions can be made by analyzing images of cells. In particular, groups of related genes and their biological functions can be predicted using images from large ...

Jones, Thouis Raymond, 1971-

2007-01-01T23:59:59.000Z

63

Characterization of a unique embedded gene  

E-Print Network [OSTI]

). Plasmids were either transformed into host cells or stored in ? 20'C as water solutions. The oligonucleotides were purchased from Gene Technologies Laboratory (GTL) in the Department of Biology at Texas A&M University (TAMU). In all experiments involving...

Zhang, Ning

1999-01-01T23:59:59.000Z

64

INVESTIGATION Coding Gene Single Nucleotide Polymorphism  

E-Print Network [OSTI]

INVESTIGATION Coding Gene Single Nucleotide Polymorphism Mapping and Quantitative Trait Loci QTL detection single nucleotide polymorphisms (SNP) reproduction Salvelinus fontinalis Linkages maps such as microsatellites and single nucleotide polymorphisms (SNPs). Also, compared with previ- ous methods based

Bernatchez, Louis

65

Characterization of the Bovine Cathelicidin Gene Family  

E-Print Network [OSTI]

genome assembly (Btau_4.0) confirmed current gene order. Comparative sequence analysis for 10 domestic cattle breeds representing both Bos taurus taurus and Bos taurus indicus revealed 60 SNPs, 7 of which were nonsynonymous, and 5 indel mutations. Data...

Flores, Erin Gillenwaters

2012-10-19T23:59:59.000Z

66

Parallel gene synthesis in a microfluidic device  

E-Print Network [OSTI]

The ability to synthesize custom de novo DNA constructs rapidly, accurately and inexpensively is highly desired by researchers, as synthetic genes and longer DNA constructs are enabling to numerous powerful applications ...

Kong, David S.

67

E-Print Network 3.0 - arthritis-associated gene-gene interaction...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Keywords: microarray, gene expression, prostate cancer... , interaction patterns, F-statistic Author for correspondence 1 Bioinformatics Oxford University Press 2004 Source:...

68

Analyzing Gene Relationships for Down Syndrome with Labeled Transition Graphs  

E-Print Network [OSTI]

Analyzing Gene Relationships for Down Syndrome with Labeled Transition Graphs Neha Rungta, Hyrum changes in gene expres- sion and physical characteristics associated with Down syndrome is not well understood. Chromosome 21 genes interact with non- chromosome 21 genes to produce Down syndrome

Brigham Young University

69

Pathogenicity island mobility and gene content.  

SciTech Connect (OSTI)

Key goals towards national biosecurity include methods for analyzing pathogens, predicting their emergence, and developing countermeasures. These goals are served by studying bacterial genes that promote pathogenicity and the pathogenicity islands that mobilize them. Cyberinfrastructure promoting an island database advances this field and enables deeper bioinformatic analysis that may identify novel pathogenicity genes. New automated methods and rich visualizations were developed for identifying pathogenicity islands, based on the principle that islands occur sporadically among closely related strains. The chromosomally-ordered pan-genome organizes all genes from a clade of strains; gaps in this visualization indicate islands, and decorations of the gene matrix facilitate exploration of island gene functions. A %E2%80%9Clearned phyloblocks%E2%80%9D method was developed for automated island identification, that trains on the phylogenetic patterns of islands identified by other methods. Learned phyloblocks better defined termini of previously identified islands in multidrug-resistant Klebsiella pneumoniae ATCC BAA-2146, and found its only antibiotic resistance island.

Williams, Kelly Porter

2013-10-01T23:59:59.000Z

70

Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma  

SciTech Connect (OSTI)

A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other epithelial cancers in a patient by delivering products that modulate Id-1 gene expression. When expressed, Id-1 gene is a prognostic indicator that cancer cells are invasive and metastatic.

Desprez, Pierre-Yves; Campisi, Judith

2014-08-19T23:59:59.000Z

71

Interference and k-point sampling in the supercell approach to phase-coherent transport K. S. Thygesen and K. W. Jacobsen  

E-Print Network [OSTI]

tight-binding model to show that interference be- tween the repeated images is a small effect compared the re- peated images. As the transverse dimensions of the supercell are increased the interference of k-point sam- pling and interference on the transmission function by means of two examples. The first

Thygesen, Kristian

72

Universal light-switchable gene promoter system  

DOE Patents [OSTI]

An artificial promoter system that can be fused upstream of any desired gene enabling reversible induction or repression of the expression of the gene at will in any suitable host cell or organisms by light is described. The design of the system is such that a molecule of the plant photoreceptor phytochrome is targeted to the specific DNA binding site in the promoter by a protein domain that is fused to the phytochrome and that specifically recognizes this binding site. This bound phytochrome, upon activation by light, recruits a second fusion protein consisting of a protein that binds to phytochrome only upon light activation and a transcriptional activation domain that activates expression of the gene downstream of the promoter.

Quail, Peter H.; Huq, Enamul; Tepperman, James; Sato, Sae

2005-02-22T23:59:59.000Z

73

Quantitative trait loci analysis to identify modifiers genes of the gene opaque2 in maize endosperm  

E-Print Network [OSTI]

fraction represents 9.5% of the 4 kernel, while other plants like soybean or beans contain 38% and 23% of protein, respectively (National Research Council, 1988). The Prolamins of Maize: The Zeins According to the classification system of cereal...Da ?-zein gene is located on chromosome 6S (bin 6.01) (Weerakoon et al., 1993). The gene encoding the 10kDa d-zein is located in chromosome 9L near the centromere (bin 9.03) (Benner et al., 1989), and the 18 kDa ?-zein gene mapped to the chromosome 6L...

Gutierrez Rojas, Libardo Andres

2009-05-15T23:59:59.000Z

74

SHORT REVIEW Ecological genomics: understanding gene and  

E-Print Network [OSTI]

SHORT REVIEW Ecological genomics: understanding gene and genome function in the natural environment MC Ungerer, LC Johnson and MA Herman Division of Biology, Ecological Genomics Institute, Kansas State University, Manhattan, KS, USA The field of ecological genomics seeks to understand the genetic mechanisms

Kaufman, Glennis A.

75

Gene encoding acetyl-coenzyme A carboxylase  

DOE Patents [OSTI]

A DNA encoding an acetyl-coenzyme A carboxylase (ACCase) from a photosynthetic organism and functional derivatives are disclosed which are resistant to inhibition from certain herbicides. This gene can be placed in organisms to increase their fatty acid content or to render them resistant to certain herbicides. 5 figs.

Roessler, P.G.; Ohlrogge, J.B.

1996-09-24T23:59:59.000Z

76

Disentangling Mental Disorders : from Genes to Circuits  

E-Print Network [OSTI]

Summer Program 2014 Disentangling Mental Disorders : from Genes to Circuits RIKEN Brain Science Application : http://www.brain.riken.jp/en/summer/ Inquiries : info.summer@brain.riken.jp RIKEN Brain Science July 15-July 22, 2014 Summer Program 2014 Summer Program 2014 RIKEN Brain Science InstituteRIKEN Brain

Kazama, Hokto

77

Gene duplications, robustness and evolutionary innovations  

E-Print Network [OSTI]

, flowering plant evolution and heart development, which encompass some of the most striking innovationsGene duplications, robustness and evolutionary innovations Andreas Wagner1,2,3 Summary Mutational with evolutionary innovation is thus a special case of a general mechanism linking innovation to robustness

Wagner, Andreas

78

Gene encoding acetyl-coenzyme A carboxylase  

DOE Patents [OSTI]

A DNA encoding an acetyl-coenzyme A carboxylase (ACCase) from a photosynthetic organism and functional derivatives thereof which are resistant to inhibition from certain herbicides. This gene can be placed in organisms to increase their fatty acid content or to render them resistant to certain herbicides.

Roessler, Paul G. (Golden, CO); Ohlrogge, John B. (Okemos, MI)

1996-01-01T23:59:59.000Z

79

E-Print Network 3.0 - atherosclerosis gene expression Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Gene Sequences In Drosophila melanogaster... , USA We performed a systematic BLAST analysis of 929 human disease gene entries associated... disease genes (77% of disease...

80

E-Print Network 3.0 - animal gene families Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

a curated database of phylogenetic trees of animal gene families... Fam: a curated database of phylogenetic trees of animal gene families 12,400 animal gene ... Source:...

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

E-Print Network 3.0 - akt-mediated gene repression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

rapid reactivation of transcription, a phenomenon known... - scription results in gene looping. After repression, genes can remain looped through interac- tions... that gene...

82

E-Print Network 3.0 - acid degradation genes Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

degradation, necessitating a gene inactivation... ). Several genes involved in steroid degradation were cloned by functional complementation of different UV... , a kstD gene...

83

E-Print Network 3.0 - alpha rara gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

genes involved in oxidative... Estimation of Gene Induction Enables a Relevance-Based Ranking of Gene Sets KILIAN BARTHOLOME,1... produced by microarray ex- periments, the...

84

Reduced expression of Autographa californica nucleopolyhedrovirus ORF34, an essential gene, enhances heterologous gene expression  

SciTech Connect (OSTI)

Autographa californica multiple nucleopolyhedrovirus ORF34 is part of a transcriptional unit that includes ORF32, encoding a viral fibroblast growth factor (FGF) and ORF33. We identified ORF34 as a candidate for deletion to improve protein expression in the baculovirus expression system based on enhanced reporter gene expression in an RNAi screen of virus genes. However, ORF34 was shown to be an essential gene. To explore ORF34 function, deletion (KO34) and rescue bacmids were constructed and characterized. Infection did not spread from primary KO34 transfected cells and supernatants from KO34 transfected cells could not infect fresh Sf21 cells whereas the supernatant from the rescue bacmids transfection could recover the infection. In addition, budded viruses were not observed in KO34 transfected cells by electron microscopy, nor were viral proteins detected from the transfection supernatants by western blots. These demonstrate that ORF34 is an essential gene with a possible role in infectious virus production.

Salem, Tamer Z. [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States) [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States); Department of Microbial Molecular Biology, AGERI, Agricultural Research Center, Giza 12619 (Egypt); Division of Biomedical Sciences, Zewail University, Zewail City of Science and Technology, Giza 12588 (Egypt); Zhang, Fengrui [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States)] [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States); Thiem, Suzanne M., E-mail: smthiem@msu.edu [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States); Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824 (United States)

2013-01-20T23:59:59.000Z

85

Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering  

E-Print Network [OSTI]

Recent advances in tissue engineering, combining an extracellular matrix (ECM)-like vehicle with therapeutic molecules, cells and/or genes has yielded promising results for brain injury repair. The purpose of this thesis ...

Bolliet, Catherine

2007-01-01T23:59:59.000Z

86

E-Print Network 3.0 - allelic based gene-gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

identify many common alleles of major effect... to that in humans7,8 , the resulting SNP density of one SNP per 500 base pairs is considerably higher than... number of genes (Fig....

87

asthma candidate genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

F.C. 38 The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia CiteSeer Summary: Dyslexia, or specific reading disability, is the most common...

88

autism candidate gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

F.C. 46 The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia CiteSeer Summary: Dyslexia, or specific reading disability, is the most common...

89

adhd candidate gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

F.C. 34 The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia CiteSeer Summary: Dyslexia, or specific reading disability, is the most common...

90

axon guidance gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Index 1 The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia CiteSeer Summary: Dyslexia, or specific reading disability, is the most common...

91

asthma susceptibility gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in the IL13 gene and atopy in all three populations (and with asthma 2005-01-01 6 The Dyslexia Susceptibility Genes and Neurodevelopment. Open Access Theses and Dissertations...

92

amoa gene analysis: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

applied to determine the core cell cycle genes in the recently Gent, Universiteit 264 Graeber et al. 2013 -Roles of Lepidium Seed Dormancy Genes 1 Spatio-temporal Seed Development...

93

analysis reveals genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

applied to determine the core cell cycle genes in the recently Gent, Universiteit 466 Graeber et al. 2013 -Roles of Lepidium Seed Dormancy Genes 1 Spatio-temporal Seed Development...

94

analysis identifies genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

applied to determine the core cell cycle genes in the recently Gent, Universiteit 490 Graeber et al. 2013 -Roles of Lepidium Seed Dormancy Genes 1 Spatio-temporal Seed Development...

95

Gene co-expression network analysis in Rhodobacter capsulatus...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

annotation. We identified R. capsulatus modules enriched with genes for ribosomal proteins, porphyrin and bacteriochlorophyll anabolism, and biosynthesis of secondary...

96

2005 Nature Publishing Group Photosynthesis genes in marine viruses yield  

E-Print Network [OSTI]

2005 Nature Publishing Group Photosynthesis genes in marine viruses yield proteins during host6 probably influences the genetic and functional diversity of both. For example, photosynthesis genes period. We also show that the expression of host photosynthesis genes declines over the course

Church, George M.

97

Message from ISCB Getting Started in Gene Orthology and Functional  

E-Print Network [OSTI]

. Each genome consists of a unique gene inventory, which determines the specific phenotype species by analyzing compositions of gene inventories therefore opens the door to the rich branch can only be identified when the whole gene inventories from all the involved species are examined

Gerstein, Mark

98

Identification of DNA marker for root-knot nematode resistance gene and characterization of disease resistance gene candidates in cotton  

E-Print Network [OSTI]

of root-knot nematode resistance (RNR) in Auburn 623 - one of the most desirable sources for RNR in Upland cottons, identification of DNA markers for the RNR genes and characterization of disease resistance gene candidates in cotton. Genetic analysis...

He, Limei

2000-01-01T23:59:59.000Z

99

E-Print Network 3.0 - arctica gene cloning Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: 19 GENE2147X KIAA0282 KIAA0282 protein GENE2906X Homo sapiens cDNA FLJ13700 fis, clone PLACE2000216... 2DTL protein GENE3683X LAD1 ladinin 1 GENE6843X Homo sapiens...

100

The impact of long-distance horizontal gene transfer on prokaryotic genome size  

E-Print Network [OSTI]

Horizontal gene transfer (HGT) is one of the most dominant forces molding prokaryotic gene repertoires. These repertoires can be as small as ?200 genes in intracellular organisms or as large as ?9,000 genes in large, ...

Cordero Sanchez, Otto Xavier

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

The Role of Multiple Transcription Factors In Archaeal Gene Expression  

SciTech Connect (OSTI)

Since the inception of this research program, the project has focused on two central questions: What is the relationship between the 'eukaryal-like' transcription machinery of archaeal cells and its counterparts in eukaryal cells? And, how does the archaeal cell control gene expression using its mosaic of eukaryal core transcription machinery and its bacterial-like transcription regulatory proteins? During the grant period we have addressed these questions using a variety of in vivo approaches and have sought to specifically define the roles of the multiple TATA binding protein (TBP) and TFIIB-like (TFB) proteins in controlling gene expression in Haloferax volcanii. H. volcanii was initially chosen as a model for the Archaea based on the availability of suitable genetic tools; however, later studies showed that all haloarchaea possessed multiple tbp and tfb genes, which led to the proposal that multiple TBP and TFB proteins may function in a manner similar to alternative sigma factors in bacterial cells. In vivo transcription and promoter analysis established a clear relationship between the promoter requirements of haloarchaeal genes and those of the eukaryal RNA polymerase II promoter. Studies on heat shock gene promoters, and the demonstration that specific tfb genes were induced by heat shock, provided the first indication that TFB proteins may direct expression of specific gene families. The construction of strains lacking tbp or tfb genes, coupled with the finding that many of these genes are differentially expressed under varying growth conditions, provided further support for this model. Genetic tools were also developed that led to the construction of insertion and deletion mutants, and a novel gene expression scheme was designed that allowed the controlled expression of these genes in vivo. More recent studies have used a whole genome array to examine the expression of these genes and we have established a linkage between the expression of specific tfb genes and the regulation of nitrogen metabolism and other global cellular responses.

Charles J. Daniels

2008-09-23T23:59:59.000Z

102

Gene Calling Standards (GSC8 Meeting)  

ScienceCinema (OSTI)

The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Nikos Kyrpides of the DOE Joint Genome Institute discusses gene calling standards at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 10, 2009.

Kyrpides, Nikos [Genome Biology Program, DOE JGI

2011-04-28T23:59:59.000Z

103

Imaging Gene Expression | The Ames Laboratory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt:ImagingImprovedImaging Gene

104

BlueGene/Q Optimization Bob Walkup  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone6 M.Extracellular Polysaccharides and Blue Gene/Q

105

G. E. (Gene) Ice | ornl.gov  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr Flickr Editor's note:ComputingFusion roadmapping about a majorGene

106

Surface enhanced Raman gene probe and methods thereof  

DOE Patents [OSTI]

The subject invention disclosed herein is a new gene probe biosensor and methods based on surface enhanced Raman scattering (SERS) label detection. The SER gene probe biosensor comprises a support means, a SER gene probe having at least one oligonucleotide strand labeled with at least one SERS label, and a SERS active substrate disposed on the support means and having at least one of the SER gene probes adsorbed thereon. Biotargets such as bacterial and viral DNA, RNA and PNA are detected using a SER gene probe via hybridization to oligonucleotide strands complementary to the SER gene probe. The support means supporting the SERS active substrate includes a fiberoptic probe, an array of fiberoptic probes for performance of multiple assays and a waveguide microsensor array with charge-coupled devices or photodiode arrays. 18 figs.

Vo-Dinh, T.

1998-09-29T23:59:59.000Z

107

Surface enhanced Raman gene probe and methods thereof  

DOE Patents [OSTI]

The subject invention disclosed is a new gene probe biosensor and methods based on surface enhanced Raman scattering (SERS) label detection. The SER gene probe biosensor comprises a support means, a SER gene probe having at least one oligonucleotide strand labeled with at least one SERS label, and a SERS active substrate disposed on the support means and having at least one of the SER gene probes adsorbed. Biotargets such as bacterial and viral DNA, RNA and PNA are detected using a SER gene probe via hybridization to oligonucleotide strands complementary to the SER gene probe. The support means supporting the SERS active substrate includes a fiberoptic probe, an array of fiberoptic probes for performance of multiple assays and a waveguide microsensor array with charge-coupled devices or photodiode arrays. 18 figs.

Vo-Dinh, T.

1998-07-21T23:59:59.000Z

108

Surface enhanced Raman gene probe and methods thereof  

DOE Patents [OSTI]

The subject invention disclosed is a new gene probe biosensor and methods based on surface enhanced Raman scattering (SERS) label detection. The SER gene probe biosensor comprises a support means, a SER gene probe having at least one oligonucleotide strand labeled with at least one SERS label, and a SERS active substrate disposed on the support means and having at least one of the SER gene probes adsorbed thereon. Biotargets such as bacterial and viral DNA, RNA and PNA are detected using a SER gene probe via hybridization to oligonucleotide strands complementary to the SER gene probe. The support means includes a fiberoptic probe, an array of fiberoptic probes for performance of multiple assays and a waveguide microsensor array with charge-coupled devices or photodiode arrays. 18 figs.

Vo-Dinh, T.

1998-02-24T23:59:59.000Z

109

was nonrandom, localized to genes and within particular regions of genes, much like sense tran-  

E-Print Network [OSTI]

number of genes. References and Notes 1. P. O. Brown, D. Botstein, Nat. Genet. 21, 33 (1999). 2. V. E (2002). 10. B. Lehner, G. Williams, R. D. Campbell, C. M. Sanderson, Trends Genet. 18, 63 (2002). 11. J Acids Res. 32, 4812 (2004). 9. M. E. Fahey, T. F. Moore, D. G. Higgins, Comp. Funct. Genomics 3, 244

Xie, Xiaoliang Sunney

110

Petascale Debugging via Allinea DDT for IBM Blue Gene /P  

E-Print Network [OSTI]

Petascale Debugging via Allinea DDT for IBM Blue Gene /P and IBM Blue Gene /Q Ian Lumb petascaling Allinea DDT Petascaling Allinea DDT for IBM Blue Gene /x Getting Started with Allinea DDT #12;0 50,000 100,000 150,000 200,000 0 0.02 0.04 0.06 0.08 0.1 0.12 DDT 3.0 Performance Figures Jaguar Cray

Kemner, Ken

111

Heterocyst Morphogenesis and Gene Expression in Anabaena sp. PCC 7120  

E-Print Network [OSTI]

experiments we found that conR (all0187) gene is necessary for normal septum-formation of vegetative cells, diazotrophic grow, and heterocyst morphogenesis. In our studies we characterized the expression of sigma factors genes in Anabaena PCC 7120 during... are developmentally regulated................... 15 Heterocyst pattern formation requires dynamic signaling............................ 17 II Anabaena SP. STRAIN PCC 7120 GENE conR (ALL0187) CONTAINS A LytR-CpsA-Psr DOMAIN, IS DEVELOPMENTALLY REGULATED...

Mella Herrera, Rodrigo Andres

2010-10-12T23:59:59.000Z

112

Engineering disease resistance with pectate lyase-like genes  

DOE Patents [OSTI]

A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

Vogel, John; Somerville, Shauna

2005-03-08T23:59:59.000Z

113

A tree-decomposed transfer matrix for computing exact Potts model partition functions for arbitrary  

E-Print Network [OSTI]

graphs, with applications to planar graph colourings Andrea Bedini1,2 and Jesper Lykke Jacobsen3 1-mail: andrea.bedini@mi.infn.it, jesper.jacobsen@ens.fr Abstract. Combining tree decomposition and transfer

Paris-Sud XI, Université de

114

autoimmunity susceptibility gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

curable by the removal of culpable antibodies and antigens. 1. unknown authors 5 The Dyslexia Susceptibility Genes and Neurodevelopment. Open Access Theses and Dissertations...

115

autism susceptibility genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the susceptibility for autism. To this end, 267 subjects with autism spectrum 3 The Dyslexia Susceptibility Genes and Neurodevelopment. Open Access Theses and Dissertations...

116

arthritis susceptibility genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

worldwide will be able to access these treatments. Yuti Chernajovsky 2005-01-01 7 The Dyslexia Susceptibility Genes and Neurodevelopment. Open Access Theses and Dissertations...

117

apoptosis gene profiling: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the application of a novel clustering algorithm, Super-Paramagnetic Clustering (SPC) to analysis of gene expression profiles that were generated recently during a study of...

118

arom gene cluster: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the application of a novel clustering algorithm, Super-Paramagnetic Clustering (SPC) to analysis of gene expression profiles that were generated recently during a study of...

119

almt1 gene cluster: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the application of a novel clustering algorithm, Super-Paramagnetic Clustering (SPC) to analysis of gene expression profiles that were generated recently during a study of...

120

aspartyl proteinase gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and pathogen Edinburgh, University of - Research Archive Summary: Parasite nematode genomics is a relatively new field9, but already two of the most interesting gene families to...

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

adenovirus early gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors CiteSeer Summary: Systemic application of...

122

acquired resistance genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and fractionation resistance Biology and Medicine Websites Summary: in Paramecium, Gout et al. 10 identify a clear relationship between high WGD duplicate gene retention...

123

Genomics, Gene Expression and Other Studies in Soybean Rust  

E-Print Network [OSTI]

Joint Genome Institute Genomics, Gene Expression and otherRust Martha Luca Posada-Buitrago Ph.D Genomics DivisionEvolutionary Genomics DOE- Joint Genome Institute Lawrence

Posada-Buitrago, Martha Lucia

2005-01-01T23:59:59.000Z

124

Mutator gene and hereditary non-polyposis colorectal cancer  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

2008-02-05T23:59:59.000Z

125

Variant translocation of the bcl-2 gene to immunoglobulin. lambda. light chain gene in chronic lymphocytic leukemia  

SciTech Connect (OSTI)

The bcl-2 gene has been identified as a gene directly involved in the consistent chromosome translocation t(14;18), which is found in {approx} 90% of human follicular lymphoma cases, and is a prime candidate for the oncogene playing a crucial role in follicular lymphomagenesis. In this paper, the authors describe a case of chronic lymphocytic leukemia showing the juxtaposition of the bcl-2 gene on chromosome 18 to immunoglobulin {lambda} light chain (Ig{lambda}) gene on chromosome 22 in a head-to-head configuration. Sequencing analysis of the joining site of the bcl-2 gene and Ig{lambda} gene has shown that the breakpoint is within the 5{prime} flanking region of the bcl-2 gene and about 2.2 kilobases 5{prime} to the joining segment of Ig{lambda} locus in a germ-line configuration. The extranucleotide, commonly appearing at the joining site of the t(14;18) translocation involving the IgH locus, is absent from the joining site of bcl-2 and Ig{lambda}. The lack of extranucleotide suggests that the juxtaposition of the bcl-2 and Ig{lambda} genes occurred during physiological rearrangement of the Ig{lambda} gene since it has been shown that the rearrangement of the Ig{lambda} locus is not accompanied by extranucleotides.

Adachi, M.; Cossman, J.; Longo, D.; Croce, C.M.; Tsujimoto, Y. (Wistar Institute of Anatomy and Biology, Philadelphia, PA (USA))

1989-04-01T23:59:59.000Z

126

COHERENCE IN ZOOPLANKTON OF A LARGE NORTHWEST ATLANTIC ECOSYSTEM1  

E-Print Network [OSTI]

declines in fish stocks (Glover 1957; Glover etaL 1961; Williamson 1961; Jacobsen 1980). Although it has

127

Gene expression profiles of Nitrosomonas europaea, an obligate chemolitotroph  

SciTech Connect (OSTI)

Nitrosomonas europaea is an aerobic lithoautotrophic bacterium that uses ammonia (NH3) as its energy source. As a nitrifier, it is an important participant in the nitrogen cycle, which can also influence the carbon cycle. The focus of this work was to explore the genetic structure and mechanisms underlying the lithoautotrophic growth style of N. europaea. Whole genome gene expression. The gene expression profile of cells in exponential growth and during starvation was analyzed using microarrays. During growth, 98% of the genes increased in expression at least two fold compared to starvation conditions. In growing cells, approximately 30% of the genes were expressed eight fold higher, Approximately 10% were expressed more than 15 fold higher. Approximately 3% (91 genes) were expressed to more than 20 fold of their levels in starved cells. Carbon fixation gene expression. N. europaea fixes carbon via the Calvin-Benson-Bassham (CBB) cycle via a type I ribulose bisphosphate carboxylase/oxygenase (RubisCO). This study showed that transcription of cbb genes was up-regulated when the carbon source was limited, while amo, hao and other energy harvesting related genes were down-regulated. Iron related gene expression. Because N. europaea has a relatively high content of hemes, sufficient Fe must be available in the medium for it to grow. The genome revealed that approximately 5% of the coding genes in N. europaea are dedicated to Fe transport and assimilation. Nonetheless, with the exception of citrate biosynthesis genes, N. europaea lacks genes for siderophore production. The Fe requirements for growth and the expression of the putative membrane siderophore receptors were determined. The N. europaea genome has over 100 putative genes ({approx}5% of the coding genes) related to Fe uptake and its siderophore receptors could be grouped phylogenetically in four clusters. Fe related genes, such as a number of TonB-dependent Fe-siderophore receptors for ferrichrome and enterobactin, and diffusion protein OmpC were expressed to higher levels under Fe limitation. N. europaea has a high Fe requirement and under Fe limiting conditions (0.2 ?M), is capable to assimilate up to 70% of the available Fe without the ability to produce siderophores.

Daniel J Arp

2005-06-15T23:59:59.000Z

128

Gene expression profiles of Nitrosomonas europaea, an obligate chemolitotroph  

SciTech Connect (OSTI)

Nitrosomonas europaea is an aerobic lithoautotrophic bacterium that uses ammonia (NH3) as its energy source. As a nitrifier, it is an important participant in the nitrogen cycle, which can also influence the carbon cycle. The focus of this work was to explore the genetic structure and mechanisms underlying the lithoautotrophic growth style of N. europaea. Whole genome gene expression: The gene expression profile of cells in exponential growth and during starvation was analyzed using microarrays. During growth, 98% of the genes increased in expression at least two fold compared to starvation conditions. In growing cells, approximately 30% of the genes were expressed eight fold higher, Approximately 10% were expressed more than 15 fold higher. Approximately 3% (91 genes) were expressed to more than 20 fold of their levels in starved cells. Carbon fixation gene expression: N. europaea fixes carbon via the Calvin-Benson-Bassham (CBB) cycle via a type I ribulose bisphosphate carboxylase/oxygenase (RubisCO). This study showed that transcription of cbb genes was up-regulated when the carbon source was limited, while amo, hao and other energy harvesting related genes were down-regulated. Iron related gene expression: Because N. europaea has a relatively high content of hemes, sufficient Fe must be available in the medium for it to grow. The genome revealed that approximately 5% of the coding genes in N. europaea are dedicated to Fe transport and assimilation. Nonetheless, with the exception of citrate biosynthesis genes, N. europaea lacks genes for siderophore production. The Fe requirements for growth and the expression of the putative membrane siderophore receptors were determined. The N. europaea genome has over 100 putative genes ({approx}5% of the coding genes) related to Fe uptake and its siderophore receptors could be grouped phylogenetically in four clusters. Fe related genes, such as a number of TonB-dependent Fe-siderophore receptors for ferrichrome and enterobactin, and diffusion protein OmpC were expressed to higher levels under Fe limitation. N. europaea has a high Fe requirement and under Fe limiting conditions (0.2 {micro}M), is capable to assimilate up to 70% of the available Fe without the ability to produce siderophores.

Daniel J. Arp

2005-05-25T23:59:59.000Z

129

INTRODUCTION Cascades of gene interactions are critical for the establishment  

E-Print Network [OSTI]

along the anterior- posterior axis, predominantly where cuticle defects are seen in embryos that lack homeotic proteins control animal development. In particular, the basis for differential regulation of target genes must be learned. Target genes can be activated by some homeotic proteins and repressed

Quake, Stephen R.

130

DETECTION AND DECOMPOSITION: TREATMENT-INDUCED CYCLIC GENE EXPRESSION  

E-Print Network [OSTI]

*,, , WENSHENG QIN,,|||| and JIN CHEN*,§,§§,|||| *MSU-DOE Plant Research Laboratory Michigan State University-induced disruption of the core set of cyclic genes (which control many downstream pathways) occurs in almost all the disruptions of two core circadian clock genes due to cold treatment in Arabidopsis.9 When a stress treatment

Qin, Wensheng

131

Lipophilic Peptides for Gene Delivery Carla A. H. Prata,  

E-Print Network [OSTI]

University, Boston, Massachusetts 02215, Department of Biological and Environmental Engineering, Cornell laboratories and in ViVo gene delivery holds the promise for curing many diseases. The synthetic carriers of lipophilic peptides including the synthesis, physio- chemical properties, cytotoxicity, and in Vitro gene

132

GenePRIMP: A software quality control tool  

SciTech Connect (OSTI)

Amrita Pati of the DOE Joint Genome Institute's Genome Biology group describes the software tool GenePRIMP and how it fits into the quality control pipeline for microbial genomics. Further details regarding GenePRIMP appear in a paper published online May 2, 2010 in Nature Methods.

Amrita Pati

2010-05-05T23:59:59.000Z

133

Hotspots of Biased Nucleotide Substitutions in Human Genes  

E-Print Network [OSTI]

Hotspots of Biased Nucleotide Substitutions in Human Genes Jonas Berglund1 , Katherine S. Pollard2) Hotspots of biased nucleotide substitutions in human genes. PLoS Biol 7(1): e1000026. doi:10.1371/journal selection in the human lineage. However, HARs tend to have biased patterns of nucleotide substitution

Sorenson, Michael

134

Photoacoustic microscopy of tyrosinase reporter gene in vivo  

E-Print Network [OSTI]

Photoacoustic microscopy of tyrosinase reporter gene in vivo Arie Krumholz Sarah J. Van microscopy of tyrosinase reporter gene in vivo Arie Krumholz,a Sarah J. VanVickle-Chavez,b Junjie Yao for tyrosinase, the primary enzyme responsible for expression of melanin in melanogenic cells. Optical res

Wang, Lihong

135

Characterization of candidate genes in English cocker spaniel hereditary nephritis  

E-Print Network [OSTI]

Six different isoforms of Type IV collagen (colIV?1-6) have been identified. The individual isoforms of colIV are termed alpha chains and are translated from six different COLIV genes (COLIVA1-A6). Collagen Type IV gene products compose...

Camacho, Zenaido

2005-02-17T23:59:59.000Z

136

GenePRIMP: A software quality control tool  

ScienceCinema (OSTI)

Amrita Pati of the DOE Joint Genome Institute's Genome Biology group describes the software tool GenePRIMP and how it fits into the quality control pipeline for microbial genomics. Further details regarding GenePRIMP appear in a paper published online May 2, 2010 in Nature Methods.

Amrita Pati

2010-09-01T23:59:59.000Z

137

RESEARCH Open Access Transient receptor potential genes, smoking,  

E-Print Network [OSTI]

RESEARCH Open Access Transient receptor potential genes, smoking, occupational exposures and cough chemicals and may play an important role in the pathogenesis of cough. The aim was to study the influence of single nucleotide polymorphisms (SNPs) in TRP genes and irritant exposures on cough. Methods: Nocturnal

Paris-Sud XI, Université de

138

Issue: April 2013 Algae Go to Extremes with "Borrowed" Genes  

E-Print Network [OSTI]

Issue: April 2013 Algae Go to Extremes with "Borrowed" Genes by Patricia Waldron Brand-New Genes their extreme environment. For example, some bacteria that live at high temperatures have special molecules that are highly acidic, or full of toxic metals. While most microbes that live in extreme environments

Schönknecht, Gerald

139

Genomic Analyses of Bacterial Porin-Cytochrome Gene Clusters  

SciTech Connect (OSTI)

The porin-cytochrome (Pcc) protein complex is responsible for trans-outer membrane electron transfer during extracellular reduction of Fe(III) by the dissimilatory metal-reducing bacterium Geobacter sulfurreducens PCA. The identified and characterized Pcc complex of G. sulfurreducens PCA consists of a porin-like outer-membrane protein, a periplasmic 8-heme c type cytochrome (c-Cyt) and an outer-membrane 12-heme c-Cyt, and the genes encoding the Pcc proteins are clustered in the same regions of genome (i.e., the pcc gene clusters) of G. sulfurreducens PCA. A survey of additionally microbial genomes has identified the pcc gene clusters in all sequenced Geobacter spp. and other bacteria from six different phyla, including Anaeromyxobacter dehalogenans 2CP-1, A. dehalogenans 2CP-C, Anaeromyxobacter sp. K, Candidatus Kuenenia stuttgartiensis, Denitrovibrio acetiphilus DSM 12809, Desulfurispirillum indicum S5, Desulfurivibrio alkaliphilus AHT2, Desulfurobacterium thermolithotrophum DSM 11699, Desulfuromonas acetoxidans DSM 684, Ignavibacterium album JCM 16511, and Thermovibrio ammonificans HB-1. The numbers of genes in the pcc gene clusters vary, ranging from two to nine. Similar to the metal-reducing (Mtr) gene clusters of other Fe(III)-reducing bacteria, such as Shewanella spp., additional genes that encode putative c-Cyts with predicted cellular localizations at the cytoplasmic membrane, periplasm and outer membrane often associate with the pcc gene clusters. This suggests that the Pcc-associated c-Cyts may be part of the pathways for extracellular electron transfer reactions. The presence of pcc gene clusters in the microorganisms that do not reduce solid-phase Fe(III) and Mn(IV) oxides, such as D. alkaliphilus AHT2 and I. album JCM 16511, also suggests that some of the pcc gene clusters may be involved in extracellular electron transfer reactions with the substrates other than Fe(III) and Mn(IV) oxides.

Shi, Liang; Fredrickson, Jim K.; Zachara, John M.

2014-11-26T23:59:59.000Z

140

Cell number regulator genes in Prunus provide candidate genes for the control of fruit size in sweet and sour cherry  

E-Print Network [OSTI]

Cell number regulator genes in Prunus provide candidate genes for the control of fruit size at Springerlink.com Abstract Striking increases in fruit size distinguish cultivated descendants from small-fruited wild progen- itors for fleshy fruited species such as Solanum lycopersicum (tomato) and Prunus spp

van der Knaap, Esther

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

E-Print Network 3.0 - amp-binding protein gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 protein... 19 GENE2147X KIAA0282 KIAA0282 protein GENE2906X Homo sapiens cDNA FLJ13700 fis, clone PLACE2000216... GENE3053X HMGIY high-mobility group (nonhistone ... Source:...

142

E-Print Network 3.0 - assembly protein gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 protein... 19 GENE2147X KIAA0282 KIAA0282 protein GENE2906X Homo sapiens cDNA FLJ13700 fis, clone PLACE2000216... GENE3053X HMGIY high-mobility group (nonhistone ... Source:...

143

E-Print Network 3.0 - arenaviruses genes proteins Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 protein... 19 GENE2147X KIAA0282 KIAA0282 protein GENE2906X Homo sapiens cDNA FLJ13700 fis, clone PLACE2000216... GENE3053X HMGIY high-mobility group (nonhistone ... Source:...

144

A study of mammalian microRNA-mediated repression of gene expression by ribosome profiling  

E-Print Network [OSTI]

All cells in a multicellular organism carry the same genes, yet these same genes direct the differentiation of many different cell types. This is facilitated by differential gene expression, the control of which can be ...

Guo, Huili

2011-01-01T23:59:59.000Z

145

Functional replacement of a primary metabolic pathway via multiple independent eukaryote-to-eukaryote gene transfers  

E-Print Network [OSTI]

Functional replacement of a primary metabolic pathway via multiple independent eukaryote can be added to the recipient's gene complement (gene additions) or simply replace existing endogenous counterparts (functional replacements). The recruitment of novel genes is thought to allow the recipient

Nedelcu, Aurora M.

146

E-Print Network 3.0 - alternative oxidase gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

alternative oxidase gene from T. hominis, G. plecoglossi... a high frequency of fast-evolving genes. ... Source: Keeling, Patrick - Department of Botany, University of British...

147

E-Print Network 3.0 - acetyl-coa carboxylase-alpha gene Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is to deter- mine the biological function of all the gene pro... microbial genomes highlights the need for func- tional characterization of the gene ... Source: Gerstein,...

148

E-Print Network 3.0 - adenoviral gene therapy Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Stanford University Collection: Biology and Medicine 46 THE JOURNAL OF GENE MEDICINE RESEARCH ARTICLE J Gene Med 2003; 5: 300310. Summary: . Alvarez RD, Gomez-Navarro J, Wang...

149

E-Print Network 3.0 - anemia gene facc Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

FRAMEWORKS FOR ENGINEERS Summary: disease and nature of the mutation that leads to Sickle Cell Anemia? E. The gene defective in Sickle Cell... Anemia is a recessive gene....

150

E-Print Network 3.0 - adult gene therapy Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: matched bone marrow donor. A clinical trial using stem cell gene therapy for sickle cell patients... team includes experts in stem cell gene therapy, clinical bone c...

151

E-Print Network 3.0 - anemia gene fancc Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

FRAMEWORKS FOR ENGINEERS Summary: disease and nature of the mutation that leads to Sickle Cell Anemia? E. The gene defective in Sickle Cell... Anemia is a recessive gene....

152

E-Print Network 3.0 - abca3 gene leads Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 11 RESOVING THE GENE TREE AND SPECIES TREE PROBLEM BY PHYLOGENETIC MINING Summary: RESOVING THE GENE TREE AND SPECIES TREE PROBLEM BY PHYLOGENETIC MINING XIAOXU...

153

E-Print Network 3.0 - anoxia-responsive gene expression Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Abstract Motivation: A central step in the analysis of gene expression data is the identification of groups... of genes that exhibit similar expression patterns. ... Source:...

154

E-Print Network 3.0 - aopex11-1 gene involved Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

genes involved in Embden... networks 4. essential genes 5. host-phage co-evolution robust phenomena new mathematical measures... . Clyde Hutchison, 1999 (Science 286, 2165-2169):...

155

E-Print Network 3.0 - alpha -chain gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

normalization... : In this paper, we present a gene normalization strategy based on the identification of gene and ... Source: Srinivasan, Padmini - School of Library and...

156

E-Print Network 3.0 - alpha -subunit gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

normalization... : In this paper, we present a gene normalization strategy based on the identification of gene and ... Source: Srinivasan, Padmini - School of Library and...

157

E-Print Network 3.0 - antipsychotic-induced gene regulation Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences 42 Estimation of Gene Induction Enables a Relevance-Based Ranking of Gene Sets Summary: methods which are focused on significance, our approach...

158

Targeting gene expression to tumor cells with loss of wild-type p53 function  

E-Print Network [OSTI]

of the carcinoembryonic antigen and -fetoprotein genes for hepatocarcinoma4,5 and of the tyrosinase gene for mel- anoma,6

Tian, Weidong

159

E-Print Network 3.0 - acid metabolic genes Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sciences and Ecology 3 Genes in the environment Genes and Ecosystems Summary: secretion Sulphur assimilation Amino acid metabolism Hypothetical proteins Sulphur...

160

E-Print Network 3.0 - accelerated gene evolution Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: accelerated gene evolution Page: << < 1 2 3 4 5 > >> 1 Gene conversion and diversification of...

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Low-Oxygen Induction of Normally Cryptic psbA Genes in Cyanobacteria...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Oxygen Induction of Normally Cryptic psbA Genes in Cyanobacteria. Low-Oxygen Induction of Normally Cryptic psbA Genes in Cyanobacteria. Abstract: Microarray analysis indicated...

162

E-Print Network 3.0 - alkaloid gene dmaw Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

search results for: alkaloid gene dmaw Page: << < 1 2 3 4 5 > >> 1 exploiting biodiversity for the improvement of natural product-based drug discovery Summary: genes thus...

163

E-Print Network 3.0 - alligator cyp3a77 gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Genetree: A TOOL FOR EXPLORING GENE FAMILY EVOLUTION Roderic D. M. Page James A. Cotton Molecular... biologists interested in the evolution of gene families and molecular...

164

Sorghum Ma5 and Ma6 maturity genes  

E-Print Network [OSTI]

the precise mechanism of function for the A. thaliana circadian clock is not fully established, at least three genes appear to be involved in the central circadian oscillator mechanism. These genes are TIMING OF CHLOROPHYLL A/B BINDING PROTEIN 1 (TOC1... the expression of CCA1 and LHY, and the gene encoding it is a target for repression by CCA1 and LHY proteins. The protein is an A. thaliana pseudo response regulator (APRR) called TIMING OF CHLOROPHYLL A/B BINDING PROTEIN 1 (TOC1), and its transcript levels...

Brady, Jeffrey Alan

2009-05-15T23:59:59.000Z

165

Analysis of the [lambda] S? gene function by mutational suppressors  

E-Print Network [OSTI]

the ssb-ral region. The ~sl C mutation which confers resistance to the plasmid borne S gene was mapped to 3 min on the E. coli chromosome and shown to impart a 6-9 minute delay in lysis by wild type The lysis regulator proposed by Campbell and Rolfe... genes transcribed from the strong pR' promoter, beginning about 8-10 minutes after induction of a l lysogen. The product of the R gene is a transglycosylase or endolysin (Campbell and Rolfe, 1975; Bienkowska and Taylor, 1980; Bienkowska et al...

Sohaskey, Charles David

2012-06-07T23:59:59.000Z

166

Mutational analysis of the [phi] X174 E Gene  

E-Print Network [OSTI]

for the rapid isolation and sequencing of E gene mutants from the screening vector pSM120 has been developed. Two nonsense mutations have been isolated which totally inactivate the E gene product. A variety of amino acids have been inserted at these non... Hydroxylami ne mutagenesis Transformation 13 16 18 19 29 29 30 30 32 33 33 36 38 38 TABLE OF CONTENTS (continued) Selection of gene E mutations in pSM120 M13 cloning and dideoxy sequencing 3. RESULTS Characterization of deletion clones...

Morham, Scott Garton

1985-01-01T23:59:59.000Z

167

Logical Gene Ontology Annotations (GOAL): Exploring gene ontology annotations with OWL  

E-Print Network [OSTI]

for each annotation): Class: MGI_2685072 oboInOwl: hasDefinition trace amineassociated receptor 4, rdfs: label Taar4 SubClassOf: Annotations: oboInOwl: evidenceCode IEA ro: located_in some GO: GO_0016021, (integral to membrane) Annotations: obo... N, Rustici G, Tikhonov A, Travillian RS, Williams E, Zorin A, Parkinson H, Brazma A: Gene Expression Atlas update - a value-added database of microarray and sequencing- based functional genomics experiments. Nucleic Acids Research 2011. 19. Jupp S...

2012-04-24T23:59:59.000Z

168

Blue Gene/Q Versus Blue Gene/P | Argonne Leadership Computing Facility  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone6 M.Extracellular Polysaccharides and Blue Gene/Q Versus Blue

169

Determination of the linkage relationships and the gene-centromere genetic distances for endopeptidase structural genes in hexaploid wheat  

E-Print Network [OSTI]

. The linkage relationships for the (EP) structural gene are shown below. centromere 42. 17 ~E -Blv 13. 04 7AL ~E-Ale 6. 67 ~E-Al 3. 90 10. 67 ACKNOMLF. DGT'KNT S Sincere gratitude is extended to all members of my graduate committee for. their guidance..., or KP-BlZ and their chromosome constitut on Linkage relationships for three (EP) structural genes on 7AL Chi square test for independence of EP-Aj. y and ~E-Alx Chi square testing the hypothesis that two independently segregating genes in FI...

McMillin, David Edwin

1977-01-01T23:59:59.000Z

170

aneurysm susceptibility genes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 The Dyslexia Susceptibility Genes and Neurodevelopment. Open Access Theses and Dissertations...

171

atrophy susceptibility gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 The Dyslexia Susceptibility Genes and Neurodevelopment. Open Access Theses and Dissertations...

172

adenosine receptor gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

James A Zwiebel; Eli Gilboa; R Michael Blaese; Arthur Nienhuis; Richard J O& apos; reilly; W. French Anderson 1987-01-01 13 Recombinant AAV-Mediated Gene Transfer for the...

173

adenosine deaminase gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

James A Zwiebel; Eli Gilboa; R Michael Blaese; Arthur Nienhuis; Richard J O& apos; reilly; W. French Anderson 1987-01-01 4 High-Efficiency Gene Transfer into Normal and...

174

Auxiliary metabolic genes in viruses infecting marine cyanobacteria  

E-Print Network [OSTI]

Marine viruses shape the diversity and biogeochemical role of their microbial hosts. Cyanophages that infect the cyanobacteria Prochlorococcus and Synechococcus often carry metabolic genes not found in other bacteriophages. ...

Thompson, Luke Richard

2010-01-01T23:59:59.000Z

175

Low-Rank Regularization for Learning Gene Expression Programs  

E-Print Network [OSTI]

8 | Issue 12 | e82146 Low-Rank for Learning Gene Expressiona convex relaxation of the rank of W [22,23]. Since nuclearcall (3) the linear low-rank model in the following. The

Ye, Guibo; Tang, Mengfan; Cai, Jian-Feng; Nie, Qing; Xie, Xiaohui; Muldoon, Mark R

2013-01-01T23:59:59.000Z

176

4.2 Selection Changes in gene frequency  

E-Print Network [OSTI]

the best-known example of this situation in man concerns the phenomenon of sickle-cell anaemia. The maintenance of high frequencies for both the sickle cell gene and its normal allele in certain East African

Hsu, Sze-Bi

177

astrocyte elevated gene-1: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cardiomyopathy; Oliver Koeth; Uwe Zeymer; Rudolf Schiele; Ralf Zahn 2010-01-01 162 Graeber et al. 2013 -Roles of Lepidium Seed Dormancy Genes 1 Spatio-temporal Seed Development...

178

antigen gene-1 induce: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of the immune system to attack foreign antigens, parasites Nowak, Martin A. 105 Graeber et al. 2013 -Roles of Lepidium Seed Dormancy Genes 1 Spatio-temporal Seed Development...

179

Brief Communication 1195 A gene trap approach in Xenopus  

E-Print Network [OSTI]

developed several gene trap vectors, using the green fluorescent protein (GFP) as a marker. Using, including expression in the epiphysis, the olfactory bulb and placodes, the eyes, ear, brain, muscles, tail

Amaya, Enrique

180

Expression of Genes Linked to NOx Detoxification in Aerobic Bacteria  

E-Print Network [OSTI]

operons referred to as the nif cluster. This suite of genesgenes not found in the nif clusters of K. pneumoniae (i.e.is high conservation among nif gene organization based on

Cua, Lynnie

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

adipose tissue gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the expression of the UCP1 gene 293 D. Norepinephrine is an apoptosis inhibitor in brown adipocytes 294 IV. How Significant Is Brown Adipose Tissue? 295 A. Parameters of...

182

The wheat ?-gliadin genes: structure and EST analysis  

E-Print Network [OSTI]

Gu : G. R. Lazo : J. Wu Genomics and Gene Discovery ResearchFunct Integr Genomics (2009) 9:397410 DOI 10.1007/s10142-physicalchemical Funct Integr Genomics (2009) 9:397410

Anderson, Olin D.; Gu, Yong Q.; Kong, Xiuying; Lazo, Gerard R.; Wu, Jiajie

2009-01-01T23:59:59.000Z

183

aldosterone synthase gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

these genes in the CNS of male Wistar Kyoto (WKY) rats in response to systemic ACTH infusion, dexamethasone infusion, and to adrenalectomy. CYP11B1 and CYP11B2 mRNA levels were...

184

High-throughput comparison of gene fitness among related bacteria  

E-Print Network [OSTI]

licenses/by/2.0), which permits unrestricted use,Mutations in this gene permit second site mutations in hnsIt is known that rpoS mutants permit mutations in hns in

2012-01-01T23:59:59.000Z

185

antagonist gene polymorphism: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

processing, short-term memory 57 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

186

antigen-4 gene polymorphisms: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

processing, short-term memory 55 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

187

antagonist gene polymorphisms: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

processing, short-term memory 57 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

188

alpha gene polymorphisms: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

processing, short-term memory 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

189

RESEARCH Open Access Gene expression and fractionation resistance  

E-Print Network [OSTI]

in Paramecium, Gout et al. [10] identify a clear relationship between high WGD duplicate gene retention rates for explaining variable resistance to fractionation. The Gout et al. paper [10] is the primary inspiration

Sankoff, David

190

Genome Enabled Discovery of Carbon Sequestration Genes in Poplar  

SciTech Connect (OSTI)

The goals of the S.H. Strauss laboratory portion of 'Genome-enabled discovery of carbon sequestration genes in poplar' are (1) to explore the functions of candidate genes using Populus transformation by inserting genes provided by Oakridge National Laboratory (ORNL) and the University of Florida (UF) into poplar; (2) to expand the poplar transformation toolkit by developing transformation methods for important genotypes; and (3) to allow induced expression, and efficient gene suppression, in roots and other tissues. As part of the transformation improvement effort, OSU developed transformation protocols for Populus trichocarpa 'Nisqually-1' clone and an early flowering P. alba clone, 6K10. Complete descriptions of the transformation systems were published (Ma et. al. 2004, Meilan et. al 2004). Twenty-one 'Nisqually-1' and 622 6K10 transgenic plants were generated. To identify root predominant promoters, a set of three promoters were tested for their tissue-specific expression patterns in poplar and in Arabidopsis as a model system. A novel gene, ET304, was identified by analyzing a collection of poplar enhancer trap lines generated at OSU (Filichkin et. al 2006a, 2006b). Other promoters include the pGgMT1 root-predominant promoter from Casuarina glauca and the pAtPIN2 promoter from Arabidopsis root specific PIN2 gene. OSU tested two induction systems, alcohol- and estrogen-inducible, in multiple poplar transgenics. Ethanol proved to be the more efficient when tested in tissue culture and greenhouse conditions. Two estrogen-inducible systems were evaluated in transgenic Populus, neither of which functioned reliably in tissue culture conditions. GATEWAY-compatible plant binary vectors were designed to compare the silencing efficiency of homologous (direct) RNAi vs. heterologous (transitive) RNAi inverted repeats. A set of genes was targeted for post transcriptional silencing in the model Arabidopsis system; these include the floral meristem identity gene (APETALA1 or AP1), auxin response factor gene (ETTIN), the gene encoding transcriptional factor of WD40 family (TRANSPARENTTESTAGLABRA1 or TTG1), and the auxin efflux carrier (PIN-FORMED2 or PIN2) gene. More than 220 transgenic lines of the 1st, 2nd and 3rd generations were analyzed for RNAi suppression phenotypes (Filichkin et. al., manuscript submitted). A total of 108 constructs were supplied by ORNL, UF and OSU and used to generate over 1,881 PCR verified transgenic Populus and over 300 PCR verified transgenic Arabidopsis events. The Populus transgenics alone required Agrobacterium co-cultivations of 124.406 explants.

Filichkin, Sergei; Etherington, Elizabeth; Ma, Caiping; Strauss, Steve

2007-02-22T23:59:59.000Z

191

Unique ER Cistromes Control Cell Type-Specific Gene Regulation  

E-Print Network [OSTI]

-specific E2 regulation of gene expression in MCF7 and U2OS- ER cells, we compared the ER binding sites on DNA a critical role in defining the ER cistrome in MCF7 cells, it is not expressed in U2OS-ER cells, and forkhead-specific effects, however, remains to be explained. We have compared the gene expres- sion profile of the MCF7

Brown, Myles

192

PI Control of Gene Expression in Tumorous Cell Lines  

E-Print Network [OSTI]

3 HT29 cell line data for starved and then fed 20% FBS group (Group 1), starved with no FBS group (Group 2), and no starvation group (Group 3) for the genes JUN, MYC, and EGR1......................................................... 15 4... Normalized HEK cell line data for starved and then fed 20% FBS group (Group 1), starved with no FBS group (Group 2), and no starvation group (Group 3) for the genes JUN, MYC, and EGR1........................................ 16 5 Normalized HT29 cell...

Mendonca, Rouella J.

2010-01-16T23:59:59.000Z

193

Localization and cloning of the gene(s) of bacteriophage PM2 responsible for membrane morphogenesis  

SciTech Connect (OSTI)

Proteins implicated in membrane morphogenesis (sp6.6 and sp13) have been previously identified by analysis of membrane proteins in the membrane of the purified phage. Analysis of a ts viral mutant that produces empty membrane vesicles also indicated the unique presence of viral structural protein sp6.6. In this work the gene for sp6.6 was localized on the PM2 genome by in vitro coupled transcription-translation directed by restriction endonuclease fragments of PM2 DNA. A Hind III fragment containing the sp6.6 gene among others was cloned into pBR322 in E. coli. Examination with the electron microscope revealed the production of new membrane vesicles whose size were similar to that of the natural membrane of PM2. Clones were then constructed in the pUC family of plasmids which uses the Lac promoter and pPL-lambda which uses the promoter left of lambda. pUC clones were unable to produce vesicles or detectable sp6.6. A pPL-lambda clone was produced 3.5 Kbp in size, that produced p6.6 as detected by SDS-PAGE of radiolabeled protein and immunoblotting.

Armour, G.A.

1988-01-01T23:59:59.000Z

194

Adaptations to Endosymbiosis in a Cnidarian- Dinoflagellate Association: Differential Gene Expression and Specific Gene Duplications  

E-Print Network [OSTI]

Trophic endosymbiosis between anthozoans and photosynthetic dinoflagellates forms the key foundation of reef ecosystems. Dysfunction and collapse of symbiosis lead to bleaching (symbiont expulsion), which is responsible for the severe worldwide decline of coral reefs. Molecular signals are central to the stability of this partnership and are therefore closely related to coral health. To decipher inter-partner signaling, we developed genomic resources (cDNA library and microarrays) from the symbiotic sea anemone Anemonia viridis. Here we describe differential expression between symbiotic (also called zooxanthellate anemones) or aposymbiotic (also called bleached) A. viridis specimens, using microarray hybridizations and qPCR experiments. We mapped, for the first time, transcript abundance separately in the epidermal cell layer and the gastrodermal cells that host photosynthetic symbionts. Transcriptomic profiles showed large inter-individual variability, indicating that aposymbiosis could be induced by different pathways. We defined a restricted subset of 39 common genes that are characteristic of the symbiotic or aposymbiotic states. We demonstrated that transcription of many genes belonging to this set is specifically enhanced in the symbiotic cells (gastroderm). A model is proposed where the aposymbiotic and therefore heterotrophic state triggers vesicular trafficking, whereas the symbiotic and therefore autotrophic state favors metabolic exchanges between host and symbiont. Several genetic pathways were investigated in more detail: i) a key vitamin Kdependant process involved in the dinoflagellate-cnidarian recognition; ii) two cnidarian

Aurlie Moya; Virginie Magnone; Denis Allem; Paola Furla; Ccile Sabourault

195

A Performance Counter Based Workload Characterization on Blue Gene/P  

E-Print Network [OSTI]

A Performance Counter Based Workload Characterization on Blue Gene/P Karthik Ganesan Lizy John V--IBM's Blue Gene/P, the second generation of the Blue Gene supercomputer is designed with a Universal Perfor instrument applications and get a profound insight into its execution on the Blue Gene/P system which could

John, Lizy Kurian

196

Biochemical and genetic analysis of hydrogen metabolism in Escherichia coli: The hydB gene. [Hydrogenase  

SciTech Connect (OSTI)

Production of active hyrodgenase by Escherichia coli requires several gene products. One of the essential genes, hydB, is encoded by a DNA fragment of approximately 1.0 kilobase. The hydB gene produced a protein with an apparent molecular weight of 32,000. The hydB gene was transcribed only under anaerobic conditions. Oxygen and nitrate repressed transcription of this gene. hydB gene transcription also required {sigma}{sup 60}, the product of the rpoN gene.

Sankar, P.; Shanmugam, K.T. (Univ. of Florida, Gainesville (USA))

1988-12-01T23:59:59.000Z

197

Bitumen fume-induced gene expression profile in rat lung  

SciTech Connect (OSTI)

Exposure to bitumen fumes during paving and roofing activities may represent an occupational health risk. To date, most of the studies performed on the biological effect of asphalt fumes have been done with regard to their content in carcinogenic polycyclic aromatic hydrocarbons (PAH). In order to gain an additional insight into the mechanisms of action of bitumen fumes, we studied their pulmonary effects in rodents following inhalation using the microarray technology. Fisher 344 rats were exposed for 5 days, 6 h/day to bitumen fumes generated at road paving temperature (170 {sup o}C) using a nose-only exposition device. With the intention of studying the early transcriptional events induced by asphalt fumes, lung tissues were collected immediately following exposure and gene expression profiles in control and exposed rats were determined by using oligonucleotide microarrays. Data analysis revealed that genes involved in lung inflammatory response as well as genes associated with PAH metabolization and detoxification were highly expressed in bitumen-exposed animals. In addition, the expression of genes related to elastase activity and its inhibition which are associated with emphysema was also modulated. More interestingly genes coding for monoamine oxidases A and B involved in the metabolism of neurotransmitters and xenobiotics were downregulated in exposed rats. Altogether, these data give additional information concerning the bitumen fumes biological effects and would allow to better review the health effects of occupational asphalt fumes exposure.

Gate, Laurent [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)]. E-mail: laurent.gate@inrs.fr; Langlais, Cristina [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Micillino, Jean-Claude [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Nunge, Herve [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Bottin, Marie-Claire [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Wrobel, Richard [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Binet, Stephane [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)

2006-08-15T23:59:59.000Z

198

Evolutionary conservation of regulatory elements in vertebrate HOX gene clusters  

SciTech Connect (OSTI)

Due to their high degree of conservation, comparisons of DNA sequences among evolutionarily distantly-related genomes permit to identify functional regions in noncoding DNA. Hox genes are optimal candidate sequences for comparative genome analyses, because they are extremely conserved in vertebrates and occur in clusters. We aligned (Pipmaker) the nucleotide sequences of HoxA clusters of tilapia, pufferfish, striped bass, zebrafish, horn shark, human and mouse (over 500 million years of evolutionary distance). We identified several highly conserved intergenic sequences, likely to be important in gene regulation. Only a few of these putative regulatory elements have been previously described as being involved in the regulation of Hox genes, while several others are new elements that might have regulatory functions. The majority of these newly identified putative regulatory elements contain short fragments that are almost completely conserved and are identical to known binding sites for regulatory proteins (Transfac). The conserved intergenic regions located between the most rostrally expressed genes in the developing embryo are longer and better retained through evolution. We document that presumed regulatory sequences are retained differentially in either A or A clusters resulting from a genome duplication in the fish lineage. This observation supports both the hypothesis that the conserved elements are involved in gene regulation and the Duplication-Deletion-Complementation model.

Santini, Simona; Boore, Jeffrey L.; Meyer, Axel

2003-12-31T23:59:59.000Z

199

Reliability of frequency- and amplitude-decoding in gene regulation  

E-Print Network [OSTI]

In biochemical signaling, information is often encoded in oscillatory signals. However, the advantages of such a coding strategy over an amplitude encoding scheme of constant signals remain unclear. Here we study the dynamics of a simple model gene promoter in response to oscillating and constant transcription factor signals. We find that in biologically-relevant parameter regimes an oscillating input can produce a more constant protein level than a constant input. Our results suggest that oscillating signals may be used to minimize noise in gene regulation.

Filipe Tostevin; Wiet de Ronde; Pieter Rein ten Wolde

2012-02-07T23:59:59.000Z

200

Divinyl ether synthase gene and protein, and uses thereof  

DOE Patents [OSTI]

The present invention relates to divinyl ether synthase genes, proteins, and methods of their use. The present invention encompasses both native and recombinant wild-type forms of the synthase, as well as mutants and variant forms, some of which possess altered characteristics relative to the wild-type synthase. The present invention also relates to methods of using divinyl ether synthase genes and proteins, including in their expression in transgenic organisms and in the production of divinyl ether fatty acids, and to methods of suing divinyl ether fatty acids, including in the protection of plants from pathogens.

Howe, Gregg A. (East Lansing, MI); Itoh, Aya (Tsuruoka, JP)

2011-09-13T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Divinyl ether synthase gene, and protein and uses thereof  

DOE Patents [OSTI]

The present invention relates to divinyl ether synthase genes, proteins, and methods of their use. The present invention encompasses both native and recombinant wild-type forms of the synthase, as well as mutants and variant forms, some of which possess altered characteristics relative to the wild-type synthase. The present invention also relates to methods of using divinyl ether synthase genes and proteins, including in their expression in transgenic organisms and in the production of divinyl ether fatty acids, and to methods of suing divinyl ether fatty acids, including in the protection of plants from pathogens.

Howe, Gregg A.; Itoh, Aya

2006-12-26T23:59:59.000Z

202

LINGUISTIC ANALYSIS OF THE NUCLEOPROTEIN GENE OF INFLUENZA A VIRUS  

SciTech Connect (OSTI)

We applied linguistic analysis approach, specifically N-grams, to classify nucleotide and amino acids sequences of nucleoprotein (NP) gene of the Influenza A virus isolated from a range of hosts and geographic regions. We considered letter frequency (1-grams), letter pairs frequency (2-grams) and triplets' frequency (3-grams). Classification trees based on 1,2,3-grams variables were constructed for the same NP nucleotide and amino acids strains and their classification efficiency were compared with the clustering obtained using phylogenetic analysis. The results have shown that disregarding positional information for a NP gene can provide the same level of recognition accuracy like alternative more complex classification techniques.

A. SKOURIKHINE; T. BURR

2000-05-01T23:59:59.000Z

203

Mutations of the tyrosinase gene produce autosomal recessive ocular albinism  

SciTech Connect (OSTI)

Albinism has historically been divided into ocular (OA) and oculocutaneous (OCA) types based on the presence or absence of clinically apparent skin and hair involvement in an individual with the ocular features of albinism. The major genes for OCA include the tyrosinase gene in OCA1 and the P gene in OCA2. X-linked and autosomal recessive OA have been described and the responsible genes have not been identified. We now present six Caucasian individuals who have the phenotype of autosomal recessive OA but who have OCA1 as shown by the presence of mutations of the tyrosinase. They had white or very light hair and white skin at birth, and cutaneous pigment developed in the first decade of life. At ages ranging from 1.5-23 years, hair color was dark blond to light brown. The skin had generalized pigment and well developed tan was present on the exposed arm and face skin of four. Iris pigment was present and iris translucency varied. Molecular analysis of the tyrosinase gene, using PCR amplification and direct di-deoxy sequencing showed the following mutations: E398Z/E398Q, P406S/g346a, R402E/T373K, ?/D383N, and H211N/T373K. The homozygous individual was not from a known consanguineous mating. T373K is the most common tyrosinase gene mutation in our laboratory. Three of these mutations are associated with a total loss of tyrosinase activity (g346a splice-site, T373K, and D383N), while four are associated with residual enzyme activity (H211N, R402E, E398Q, and P406S). These studies show that mutations of the tyrosinase gene can produce the phenotype of autosomal recessive OA in an individual who has normal amounts of cutaneous pigment and the ability to tan after birth. This extends the phenotypic range of OCA1 to normal cutaneous pigment after early childhood, and suggest that mutations of the tyrosinase gene account for a significant number of individuals with autosomal recessive OA.

King, R.A.; Summers, C.G.; Oetting, W.S. [Univ. of Minnesota, Minneapolis, MN (United States)] [and others

1994-09-01T23:59:59.000Z

204

The lysis genes of bacteriophage 21: structure and function  

E-Print Network [OSTI]

(Campbell and Rolfe, 1975, Garret et al. , 1981). The most distal gene in the lysis "overlappon", le, is of unknown function and is required for lysis only under conditions of high osmolarity such as 10mH HgC12 (Young et al. , 1979). The fl gene encodes.... As mentioned above, respiratory poisons such as cyanide or dinitrophenol have been shown to trigger pg pr'ematurely in the lytic cycle, presumably by subverting the delayed action timing of pS (Campbell and Rolfe, 1975, Garret et al. , 1981). This model...

Bonovich, Maria Teresa

2012-06-07T23:59:59.000Z

205

Isolation and characterization of Agouti: a diabetes/obesity related gene  

DOE Patents [OSTI]

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

Woychik, Richard P. (Knoxville, TN)

2000-06-27T23:59:59.000Z

206

Isolation and characterization of Agouti: a diabetes/obesity related gene  

DOE Patents [OSTI]

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

Woychik, Richard P. (Knoxville, TN)

1998-01-01T23:59:59.000Z

207

Genome Function and Nuclear Architecture: From Gene Expression to Nanoscience  

E-Print Network [OSTI]

Genome Function and Nuclear Architecture: From Gene Expression to Nanoscience Timothy P. O'Brien,1, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold, and nanoscience to relate genome organization and nuclear archi- tecture with development and disease. Integrating

Langowski, Jörg

208

Lower Oil Prices: A Reason to Give Thanks GENE EPSTEIN  

E-Print Network [OSTI]

Lower Oil Prices: A Reason to Give Thanks By GENE EPSTEIN Nov. 29, 2014 1:31 a.m. ET I give thanks thanks for an oil price that fell below $70 a barrel Friday, mainly because it bodes well for general early this year ("Here Comes $75 Oil," March 31). Amy Jaffe, executive director of energy

California at Davis, University of

209

Trends in Antibiotic Resistance Genes Occurrence in the Haihe  

E-Print Network [OSTI]

D P E D R O J . J . A L V A R E Z * , | Tianjin Key Laboratory of Environmental Remediation and antibiotic resistance genes (ARGs) was quantified in water and sediment samples collected from a 72 km leads the world in antibiotic use, about 210 000 tons of antibiotics are produced every year, with 180

Alvarez, Pedro J.

210

Symbolic Discriminant Analysis for Mining Gene Expression Patterns Jason Moore  

E-Print Network [OSTI]

multivariate statistical approach for classification of observations into groups because the theory is wellSymbolic Discriminant Analysis for Mining Gene Expression Patterns Jason Moore Vanderbilt: Leukemia Jason H. Moore, Joel S. Parker, Lance W. Hahn Linear discriminant analysis is a popular

Fernandez, Thomas

211

Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes  

E-Print Network [OSTI]

, Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, Apartado Postal 565-A, Av Universidad, Cuernavaca, Morelos, 62100 Mexico D.F., Mexico Edited by Aaron Klug, Medical Research Council to influence gene expression (6­11). Thus, unlike in prokaryotes, transcription in eukaryotes is an energy

Babu, M. Madan

212

Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes  

E-Print Network [OSTI]

studied are the ways that major components of the diet such as protein, fat, and lifestyle issues impactDiet, nutrients, phytochemicals, and cancer metastasis suppressor genes Gary G. Meadows # Springer and mortality of cancer patients is metastasis. There exists a relative lack of specific therapeutic approaches

Collins, Gary S.

213

ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY  

E-Print Network [OSTI]

are more related to the kind of cancer than to drug activity patterns. Dependency analysis using Bayesian1 11 ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY CLUSTERING AND BAYESIAN of data produced from up- to-date biological experimental processes needs appropriate data mining

214

NUCLEOTIDE SUBSTITUTIONS AND THE EVOLUTION OF DUPLICATE GENES  

E-Print Network [OSTI]

167 NUCLEOTIDE SUBSTITUTIONS AND THE EVOLUTION OF DUPLICATE GENES JOHN S. CONERY Computational to gener- ate a corresponding alignment of the underlying nucleotide sequences and perform a codon by codon comparison of the nucleotides. Observed numbers of nucleotide substitutions can be used to make inferences

Oregon, University of

215

ORIGINAL ARTICLE Regulation of nif gene expression and the  

E-Print Network [OSTI]

ORIGINAL ARTICLE Regulation of nif gene expression and the energetics of N2 fixation over the diel importance in biogeochemical cycling of nitrogen. We analyzed the levels of nif transcripts of Synechococcus ecotypes, NifH subunit and nitrogenase activity over the diel cycle in the microbial mat of an alkaline hot

216

Uncorrected Proof Copy Finding Genes by Using Computational Tools 85  

E-Print Network [OSTI]

Uncorrected Proof Copy Finding Genes by Using Computational Tools 85 Job: Plant Functional Genomics;Uncorrected Proof Copy 86 Davuluri and Zhang Job: Plant Functional Genomics--Grotewold Compositor: Nettype Job: Plant Functional Genomics--Grotewold Compositor: Nettype Chapter: Chapter 6 Date: 3/15/2003 Pub

217

MICROFLUIDIC DEVICES FOR GENENTIC ANAYLSIS AND GENE EXPRESSION STUDIES  

E-Print Network [OSTI]

MICROFLUIDIC DEVICES FOR GENENTIC ANAYLSIS AND GENE EXPRESSION STUDIES Thesis by Jian Liu field of microfluidics. His advice has helped me out many times when I was struggling in my research, Ziyang Ma, Emil Kartalov, and many other colleagues. I thank Dr. Jessica Melin and the microfluidic

Quake, Stephen R.

218

Plasticity of opsin gene expression in cichlids from Lake Malawi  

E-Print Network [OSTI]

Plasticity of opsin gene expression in cichlids from Lake Malawi CHRISTOPHER M. HOFMANN, KELLY E. O plasticity has important evolutionary implications. In this study, we examined retinal plasticity in five found that the magnitude of plasticity varied across species. These findings have important implications

Carleton, Karen L.

219

From Biophysics to Evolutionary Genetics: Statistical Aspects of Gene Regulation  

E-Print Network [OSTI]

be explained in terms of their gene numbers. If, however, a biological function requires the concerted action histones, chromatin, micro-RNAs etc. become relevant, which are just entering the stage of model building in bioinformatics, with the aim of identifying statistical characteristics of functional loci and of building search

Lässig, Michael

220

Inflammatory Gene Expression in Goats in Response to Transport  

E-Print Network [OSTI]

was to determine whether expression of immune-related genes changes in goats that are exposed to transport stress. In this study, 15 Spanish-Boer goats ranging from 3 to 4 yrs of age were transported for 12 h. Goats were divided into 5 groups of 3 and placed in 1...

Carter, Mark

2012-10-19T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

RESEARCH ARTICLE Open Access Identification of lignin genes and regulatory  

E-Print Network [OSTI]

RESEARCH ARTICLE Open Access Identification of lignin genes and regulatory sequences involved analysis revealed 18 lignin isoforms for each species. We also identified five contigs homologous to R2R3 wall formation and lignin deposition. We searched the contigs against public microRNA database

222

Duplicated genes evolve independently after polyploid formation in cotton  

E-Print Network [OSTI]

Duplicated genes evolve independently after polyploid formation in cotton Richard C. Cronn to characterize the evolution of homoeologous loci in allopolyploid cotton (Gossypium hirsutum) and in species from organismal history was recovered. In contrast to observations involving repetitive DNAs in cotton

Wendel, Jonathan F.

223

Gene Delivery DOI: 10.1002/anie.201302820  

E-Print Network [OSTI]

(10­25 peptide residues) and lack adequate cationic charge to efficiently condense and deliver genes vehicles to improve delivery efficiencies.[11] We recently developed high-molecular-weight (MW), cationic efficiency and chemotoxicity of these polymeric vectors are often closely related to the density

Cheng, Jianjun

224

Microbial metatranscriptomics : towards understanding microbial gene expression and regulation in natural habitats  

E-Print Network [OSTI]

Metagenomic research has paved the way for a comprehensive understanding of the microbial gene parts list in nature, but a full understanding of microbial gene expression, regulation, and ecology remains a challenge. In ...

Shi, Yanmei, Ph. D. Massachusetts Institute of Technology

2011-01-01T23:59:59.000Z

225

Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain  

E-Print Network [OSTI]

C: A screen for downstream effectors of Neurogenin2 in theNumayama-Tsuruta et al. : Downstream genes of Pax6 revealedARTICLE Open Access Downstream genes of Pax6 revealed by

2010-01-01T23:59:59.000Z

226

Finding minimum gene subsets with heuristic breadth-first search algorithm for robust tumor classification  

E-Print Network [OSTI]

Background: Previous studies on tumor classification based on gene expression profiles suggest that gene selection plays a key role in improving the classification performance. Moreover, finding important tumor-related ...

Wang, Shu-Lin; Li, Xue-Ling; Fang, Jianwen

2012-07-25T23:59:59.000Z

227

Tissue-engineered liver microreactor as an in vitro surrogate assay for gene delivery  

E-Print Network [OSTI]

The lack of correlation between in vitro and in vivo gene delivery experiments presents a significant obstacle in the progress of gene therapy studies by preventing the extrapolation of successful cell culture results into ...

Kalezi, Artemis

2007-01-01T23:59:59.000Z

228

E-Print Network 3.0 - alpha-amylase inhibitor genes Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

amylase inhibitor genes Search Powered by Explorit Topic List Advanced Search Sample search results for: alpha-amylase inhibitor genes Page: << < 1 2 3 4 5 > >> 1 1 Stryer,L....

229

HOPEGM REPORT Primate Origins of Human Evolution: From Genes to Mind  

E-Print Network [OSTI]

HOPEGM REPORT Primate Origins of Human Evolution: From Genes to Mind Japan Society of Human Evolution: From Genes to Mind" (HOPE GM) , is a program funded by the Japan Society

Takada, Shoji

230

Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and animals  

DOE Patents [OSTI]

Novel double and triple fusion reporter gene constructs harboring distinct imageable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in living cells and in living animals using distinct imaging technologies.

Gambhir; Sanjiv (Portola Valley, CA), Pritha; Ray (Mountain View, CA)

2009-04-28T23:59:59.000Z

231

Cloning and sequencing of the alcohol dehydrogenase II gene from Zymomonas mobilis  

DOE Patents [OSTI]

The alcohol dehydrogenase II gene from Zymomonas mobilis has been cloned and sequenced. This gene can be expressed at high levels in other organisms to produce acetaldehyde or to convert acetaldehyde to ethanol.

Ingram, Lonnie O. (Gainesville, FL); Conway, Tyrrell (Gainesville, FL)

1992-01-01T23:59:59.000Z

232

E-Print Network 3.0 - adenoviral-mediated gene transfer Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biology and Medicine ; Environmental Sciences and Ecology 11 THE JOURNAL OF GENE MEDICINE RESEARCH ARTICLE J Gene Med 2003; 5: 300310. Summary: . Alvarez RD, Gomez-Navarro J, Wang...

233

E-Print Network 3.0 - adenoviral-mediated mikappabalpha gene...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Health Science Center Collection: Biology and Medicine 9 THE JOURNAL OF GENE MEDICINE RESEARCH ARTICLE J Gene Med 2003; 5: 300310. Summary: . Alvarez RD, Gomez-Navarro J, Wang...

234

E-Print Network 3.0 - acbp gene expression Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

acbp gene expression Search Powered by Explorit Topic List Advanced Search Sample search results for: acbp gene expression Page: << < 1 2 3 4 5 > >> 1 Membrane Charge and Curvature...

235

E-Print Network 3.0 - aurata hemoglobin genes Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Rochester Collection: Biology and Medicine 2 25% chance of a child with sickle cell trait Summary: hemoglobin gene D hemoglobin D gene S A A D A A S AA D DA S...

236

E-Print Network 3.0 - auxin-regulated gene expression Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

regulated gene expression Search Powered by Explorit Topic List Advanced Search Sample search results for: auxin-regulated gene expression Page: << < 1 2 3 4 5 > >> 1 Funct Integr...

237

E-Print Network 3.0 - alter genes involved Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

5 MAY 2006 537 Gene prioritization through genomic Summary: Carmeliet2 & Yves Moreau4 The identification of genes involved in health and disease remains a challenge. We... on their...

238

E-Print Network 3.0 - amplified rrna gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: number 54, overexpressing rRNA from an inducible promoter 66, deleting the fis gene 20,67 (see... response specifically associated with changes in rRNA gene dosage...

239

Evolution of a Core Gene Network for Skeletogenesis in Jochen Hecht1,2  

E-Print Network [OSTI]

Evolution of a Core Gene Network for Skeletogenesis in Chordates Jochen Hecht1,2 , Sigmar Stricker2: Hecht J, Stricker S, Wiecha U, Stiege A, Panopoulou G, et al (2008) Evolution of a Core Gene Network

Max-Planck-Institut für molekulare Genetik

240

Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity  

E-Print Network [OSTI]

Filarial nematodes are metazoan parasites with genome sizes of > 100 million base pairs, probably encoding 15 000-20 000 genes. Within this considerable gene complement, it seems likely that filariae have evolved ...

Maizels, Rick; Blaxter, Mark; Scott, Alan

2001-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

E-Print Network 3.0 - arabinoside-metabolizing enzyme genes Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

genes The tropical tree whose fruit... of its genome -- about 372 million letters of DNA code -- the papaya has surprisingly few genes -- under... roughly the same size, but have...

242

Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki  

E-Print Network [OSTI]

Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki Cancer Gene Therapy Group, Molecular Cancer Biology Program & Transplantation Laboratory & Haartman Institute & Finnish Institute, Helsinki, Finland Summary Metastatic cancer remains difficult to treat effectively and treatments

Hemminki, Akseli

243

Discovery of Candidate Genes for Stallion Fertility from the Horse Y Chromosome  

E-Print Network [OSTI]

significant differential expression in testis of normal fertile stallions and stallions with impaired fertility. Gene copy number analysis showed that the average copy number of 4 such genes was decreased in subfertile/infertile stallions compared to normal...

Paria, Nandina

2012-02-14T23:59:59.000Z

244

Genetic analyses of the Rb and p53 genes in murine development and tumorigenesis  

E-Print Network [OSTI]

The RB and p53 genes play central roles in cell cycle and checkpoint control, apoptosis and many other biological processes. These are central tumor suppressor genes that are each inactivated in many human cancers. Mouse ...

MacPherson, David (David P.)

2005-01-01T23:59:59.000Z

245

Identification of endometrial genes important for conceptus survival and development in sheep  

E-Print Network [OSTI]

from Day 14 cyclic, pregnant, and bred UGKO ewes, as well as ewes treated with interferon tau (IFN??) and progesterone, to identify genes important for conceptus development. A number of novel and previously known IFN??-stimulated genes, as well...

Gray, Catherine Allison

2005-08-29T23:59:59.000Z

246

TABASCO: A single molecule, base-pair resolved gene expression simulator  

E-Print Network [OSTI]

Background Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavior. Given our current understanding of gene ...

Kosuri, Sriram

247

Visualizing the Gene Ontology-Annotated Clusters of Co-expressed Genes: A Two-Design Study  

E-Print Network [OSTI]

of bioprocesses is largely driven by the co-ordinated expression of genes [3]. HTP-GOMinerTM [4] and Exploratory-child relationship between GO terms. The cluster map presented in HTP- GOMinerTM is a form of color matrix designed

Hong,Seokhee

248

Identification of a novel gene family that includes the interferon-inducible human genes 616and ISG12  

E-Print Network [OSTI]

renamed as ISG12(a)) are ISGs that encode small hydro- phobic proteins (Mr 12.9 kDa and 11.5 kDa, respec- tively). The predicted proteins share 36% overall amino- acid identity and 49% identity over an ~80 amino acid length. Both genes are regulated...

Parker, Nadeene; Porter, Andrew C G

2004-01-19T23:59:59.000Z

249

Systematic analysis of gene expression in human brains before and after death  

E-Print Network [OSTI]

substantially Table 2 Functional analysis of gene expression differences between autopsy and resection samples GO ID Term Expressed genes Significant differences* Change p value Conservation p value GO:0006412 Protein biosynthesis 462 101 (37/64) 0.001 0.999 GO... functional processes. Genes involved in rather basic functions, such as RNA processing, protein bio- synthesis and transport, organelle organization and biogen- esis, the ubiquitin cycle, and DNA repair (Table 1) are over- represented among genes differently...

Franz, Henriette; Ullmann, Claudia; Becker, Albert; Ryan, Margaret; Bahn, Sabine; Arendt, Thomas; Simon, Matthias; Paabo, Svante; Khaitovich, Philipp

2005-12-30T23:59:59.000Z

250

Gene mapping of bovine phosphoribosylglycinamide synthetase (PRGS) and phosphoribosylaminoimidazole synthetase (PAIS) in hybrid somatic cells  

E-Print Network [OSTI]

independent lines and displayed equally vigorous segregation of other cattle gene products. The data support a syntenic relationship of bovine PRGS, PAIS, SOD1 and IFREC, and a linkage conservation with human chromosome 21. PRGS, PAIS, and SOD1 also... of their linkage relationships to marker genes. A genetic map is a zepresentation of the physical and recombinational zelationships of genes on chromosomes. Markers used for mapping may be the actual DNA sequences, expressed. gene products, functions...

McAvin, James Charles

1986-01-01T23:59:59.000Z

251

The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion  

E-Print Network [OSTI]

MB TIF) Figure S2 The CAX (calcium exchanger) transporterFor example, two CAX (calcium exchange) transporter genes

Coleman, J.J.

2010-01-01T23:59:59.000Z

252

The effect of PKG II deficiency on osteoblast-specific gene expression in mice  

E-Print Network [OSTI]

mice develop osteoporosis and arterial calcification. GenesOPG -/- mice suffer osteoporosis, a hollowing of the bone

Alwood, Amanda Raquel

2011-01-01T23:59:59.000Z

253

A flood-based information flow analysis and network minimization method for gene regulatory networks  

E-Print Network [OSTI]

tend to have high interconnectivity, complex topologies andSince feedback and high interconnectivity is common in gene

Pavlogiannis, Andreas; Mozhayskiy, Vadim; Tagkopoulos, Ilias

2013-01-01T23:59:59.000Z

254

E-Print Network 3.0 - anti-aging gene klotho Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

chemical entities... Gene regulatory networks Inferred from: - protein interaction networks - micro-array data - other... 's Signaling pathwas: rarer reactants,...

255

E-Print Network 3.0 - active genes based Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

genes'). Acknowledgment This ... Source: Stotz, Karola - Department of History and Philosophy of Science, Indiana University Collection: Multidisciplinary Databases and...

256

Effect of metallothionein 2A gene polymorphism on allele-specific gene expression and metal content in prostate cancer  

SciTech Connect (OSTI)

Metallothioneins (MTs) are highly conserved, small molecular weight, cysteine rich proteins. The major physiological functions of metallothioneins include homeostasis of essential metals Zn and Cu and protection against cytotoxicity of heavy metals. The aim of this study was to determine whether there is an association between the ? 5 A/G single nucleotide polymorphism (SNP; rs28366003) in core promoter region and expression of metallothionein 2A (MT2A) gene and metal concentration in prostate cancer tissues. MT2A polymorphism was determined by the polymerase chain reactionrestriction fragment length polymorphism technique (PCRRFLP) using 412 prostate cancer tissue samples. MT2A gene expression analysis was performed by real-time RT-PCR method. A significant association between rs28366003 genotype and MT2A expression level was found. The average mRNA level was found to be lower among minor allele carriers (the risk allele) than average expression among homozygotes for the major allele. Metal levels were analyzed by flamed atomic absorption spectrometer system. Highly statistically significant associations were detected between the SNP and Cd, Zn, Cu and Pb levels. The results of Spearman's rank correlation showed that the expressions of MT2A and Cu, Pb and Ni concentrations were negatively correlated. On the basis of the results obtained in this study, we suggest that SNP polymorphism may affect the MT2A gene expression in prostate and this is associated with some metal accumulation. - Highlights: MT2A gene expression and metal content in prostate cancer tissues Association between SNP (rs28366003) and expression of MT2A Significant associations between the SNP and Cd, Zn, Cu and Pb levels Negative correlation between MT2A gene expression and Cu, Pb and Ni levels.

Krze?lak, Anna; Forma, Ewa [Department of Cytobiochemistry, University of ?d?, Pomorska 141/143, 90-236 ?d? (Poland); Chwatko, Gra?yna [Department of Environmental Chemistry, University of ?d?, Pomorska 163, 90-236 ?d? (Poland); J?wiak, Pawe?; Szymczyk, Agnieszka [Department of Cytobiochemistry, University of ?d?, Pomorska 141/143, 90-236 ?d? (Poland); Wilkosz, Jacek; R?a?ski, Waldemar [2nd Department of Urology, Medical University of ?d?, Pabianicka 62, 93-513 ?d? (Poland); Bry?, Magdalena, E-mail: zreg@biol.uni.lodz.pl [Department of Cytobiochemistry, University of ?d?, Pomorska 141/143, 90-236 ?d? (Poland)

2013-05-01T23:59:59.000Z

257

The role of gene fusions in the evolution of metabolic pathways: the histidine biosynthesis case  

E-Print Network [OSTI]

analysis of his gene fusions in available genomes to understand the role of gene fusions in shaping this pathway. Results The analysis of HisA structures revealed that several gene elongation events are at the root of this protein family: internal...

2007-08-16T23:59:59.000Z

258

Gene- or region-based association study via kernel principal component analysis  

E-Print Network [OSTI]

. The American Journal of Human Genetics 2005, 77(4):567-581. 43. Kllberg H, Padyukov L, Plenge R, Rnnelid J, Gregersen P, van der Helm-van Mil A, Toes R, Huizinga T, Klareskog L, Alfredsson L: Gene-gene and gene- environment interactions involving HLA-DRB1...

Gao, Qingsong; He, Yungang; Yuan, Zhongshang; Zhao, Jinghua; Zhang, Bingbing; Xue, Fuzhong

2011-08-26T23:59:59.000Z

259

PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs  

E-Print Network [OSTI]

2005, 77:567-581. 23. Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, Helm-van Mil van der AHM, Toes REM, Huizinga TW, Klareskog L, Alfredsson L, et al: Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking...

Peng, Qianqian; Zhao, Jinghua; Xue, Fuzhong

2010-01-26T23:59:59.000Z

260

A Gene Necessary for Normal Male Courtship, yellow, Acts Downstream of fruitless in the  

E-Print Network [OSTI]

A Gene Necessary for Normal Male Courtship, yellow, Acts Downstream of fruitless in the Drosophila- ship behavior, genes acting downstream of fru have not yet been identified. Here we demonstrate that the yellow (y) gene is genetically downstream of fru in the 3rd -instar larval brain. Yellow protein

Gruber, Jonathan

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

LETTER doi:10.1038/nature11279 The long-range interaction landscape of gene  

E-Print Network [OSTI]

engage in looping interactions that have been implicated in gene regulation1 . Here we have applied chromosome conforma- tion capture carbon copy (5C2 ) to interrogate comprehensively interactions between gene domains. Furthermore, only 7% of looping interactions are with the nearest gene, indicating

Dean, Matthew D.

262

Isolated gene encoding an enzyme with UDP-glucose pyrophosphorylase and phosphoglucomutase activities from Cyclotella cryptica  

DOE Patents [OSTI]

The present invention relates to a cloned gene which encodes an enzyme, the purified enzyme, and the applications and products resulting from the use of the gene and enzyme. The gene, isolated from Cyclotella cryptica, encodes a multifunctional enzyme that has both UDP-glucose pyrophosphorylase and phosphoglucomutase activities. 8 figs.

Jarvis, E.E.; Roessler, P.G.

1999-07-27T23:59:59.000Z

263

Red Algae Lose Key Mitochondrial Genes in Response to Becoming Parasitic  

E-Print Network [OSTI]

Red Algae Lose Key Mitochondrial Genes in Response to Becoming Parasitic Lillian Hancock1 , Lynda independently evolved hundreds of times among the floridiophyte red algae. Much is known about the life history class of red algae, Plocamiocolax puvinata, has lost the atp8 gene entirely, indicating that this gene

Lane, Chris

264

Carotenoid Gene Nucleotide Diversity Reflects Carrot History and J. Clotault1  

E-Print Network [OSTI]

Carotenoid Gene Nucleotide Diversity Reflects Carrot History and Selection J. Clotault1 , Emmanuel. The purpose of our work was to study the nucleotide diversity of carotenoid biosynthesis genes. A sample of 48). Compared to other species, a quite high single nucleotide (SNP) frequency was found for these genes (1

Paris-Sud XI, Université de

265

A Model of Gene Expression and Regulation in an Artificial Cellular Organism  

E-Print Network [OSTI]

expression and regulation based on the operon model of Jacob and Monod. Operons are groups of genes regulated and complexity of gene expression in real cells and it should also bear close relationships to EC so that it can, Jacob and Monod developed the operon model of gene expression and regulation [1, 5, 7] to explain

Fernandez, Thomas

266

Microtargeted gene silencing and ectopic expression in live embryos using biolistic delivery with a pneumatic capillary gun  

E-Print Network [OSTI]

a Pneumatic Capillary Gun Orit Shefi, 1 Claire Simonnet, 2medicinalis; netrin; gene gun Introduction Modulating geneby the current design of gene guns used for particle

Shefi, Orit; Simonnet, Claire; Baker, Michael W; Glass, James R; Macagno, Eduardo R; Groisman, Alex

2006-01-01T23:59:59.000Z

268

Analysis of genes regulated by the peroxide response regulator PerR in Borrelia burgdorferi using real-time RT-PCR  

E-Print Network [OSTI]

encodes a peroxide response regulator (PerR) which regulates gene expression in response to oxidative stress in other organisms. Several borrelial genes with homology to known oxidative stress genes, and the pathogenesis-associated gene dbpA, contain...

Swingle, Kristen Lynn

2002-01-01T23:59:59.000Z

269

Plant isoflavone and isoflavanone O-methyltransferase genes  

DOE Patents [OSTI]

The invention provides enzymes that encode O-methyltransferases (OMTs) from Medicago truncatula that allow modification to plant (iso)flavonoid biosynthetic pathways. In certain aspects of the invention, the genes encoding these enzymes are provided. The invention therefore allows the modification of plants for isoflavonoid content. Transgenic plants comprising such enzymes are also provided, as well as methods for improving disease resistance in plants. Methods for producing food and nutraceuticals, and the resulting compositions, are also provided.

Broeckling, Bettina E.; Liu, Chang-Jun; Dixon, Richard A.

2014-08-19T23:59:59.000Z

270

Pnp gene modification for improved xylose utilization in Zymomonas  

DOE Patents [OSTI]

The endogenous pnp gene encoding polynucleotide phosphorylase in the Zymomonas genome was identified as a target for modification to provide improved xylose utilizing cells for ethanol production. The cells are in addition genetically modified to have increased expression of ribose-5-phosphate isomerase (RPI) activity, as compared to cells without this genetic modification, and are not limited in xylose isomerase activity in the absence of the pnp modification.

Caimi, Perry G G; Qi, Min; Tao, Luan; Viitanen, Paul V; Yang, Jianjun

2014-12-16T23:59:59.000Z

271

GENE E. LIKENS FOUNDING DIRECTOR AND PRESIDENT EMERITUS  

E-Print Network [OSTI]

. Likens. 2012. Acid rain, in Encyclopedia of Environmetrics Second Edition. In: A.-H. El-Shaarawi and W Butler, T. J. and G.E. Likens. 2012. Acid rain, in Encyclopædia Britannica. Encyclopædia Britannica://www.britannica.com/EBchecked/topic/3761/acid-rain> #12;2012-13 Annual Report -- Dr. Gene E. Likens 2 D'Elia, C. F and G. E. Likens. 2012

Canham, Charles D.

272

Transcriptional regulation of the Arabidopsis thaliana chalcone synthase gene  

SciTech Connect (OSTI)

The authors cloned an Arabiodpsis thaliana chalcone synthase (CHS) gene on the basis of cross-hybridization with a Petroselinum hortense CHS cDNA clone. The protein sequence deduced from the A. thaliana CHS DNA sequence is at least 85% homologous to the CHS sequences from P. hortense, Antirrhinum majus, and Petunia hybrida. Southern blot analysis indicated that CHS is a single-copy gene in A. thaliana. High-intensity light treatment of A. thaliana plants for 24 h caused a 50-fold increase in CHS enzyme activity and an accumulation of visibly detectable levels of anthocyanin pigments in the vegetative structures of these plants. A corresponding increase in the steady-state level of CHS mRNA was detected after high-intensity light treatment for the same period of time. The accumulation of CHS mRNA in response to high-intensity light was due, at least in part, to an increased rate of transcription of the CHS gene as demonstrated by nuclear runoff experiment.

Feinbaum, R.L.; Ausubel, F.M.

1988-05-01T23:59:59.000Z

273

Compositions and methods for detecting gene rearrangements and translocations  

DOE Patents [OSTI]

Disclosed is a series of nucleic acid probes for use in diagnosing and monitoring certain types of leukemia using, e.g., Southern and Northern blot analyses and fluorescence in situ hybridization (FISH). These probes detect rearrangements, such as translocations involving chromosome band 11q23 with other chromosomes bands, including 4q21, 6q27, 9p22, 19p13.3, in both dividing leukemic cells and interphase nuclei. The breakpoints in all such translocations are clustered within an 8.3 kb BamHI genomic region of the MLL gene. A novel 0.7 kb BamH1 cDNA fragment derived from this gene detects rearrangements on Southern blot analysis with a single BamHI restriction digest in all patients with the common 11q23 translocations and in patients with other 11q23 anomalies. Northern blot analyses are presented demonstrating that the MLL gene has multiple transcripts and that transcript size differentiates leukemic cells from normal cells. Also disclosed are MLL fusion proteins, MLL protein domains and anti-MLL antibodies.

Rowley, Janet D. (Chicago, IL); Diaz, Manuel O. (Chicago, IL)

2000-01-01T23:59:59.000Z

274

Probing cell-free gene expression noise in femtoliter volumes  

SciTech Connect (OSTI)

Cell-free systems offer a simplified and flexible context that enables important biological reactions while removing complicating factors such as fitness, division, and mutation that are associated with living cells. However, cell-free expression in unconfined spaces is missing important elements of expression in living cells. In particular, the small volume of living cells can give rise to significant stochastic effects, which are negligible in bulk cell-free reactions. Here, we confine cell-free gene expression reactions to cell relevant 20 fL volumes (between the volumes of E. coli and S. cerevisiae), in polydimethylsiloxane (PDMS) containers. We demonstrate that expression efficiency varies widely at this volume, and we analyze gene expression noise. Noise analysis reveals signatures of translational bursting while noise dynamics suggest that overall cell-free expression is limited by a diminishing translation rate. In addition to offering a unique approach to understanding noise in gene circuits, our work contributes to a deeper understanding of the biophysical properties of cell-free expression systems, thus aiding efforts to harness cell-free systems for synthetic biology applications.

Karig, David K [ORNL; Jung, Seung-Yong [ORNL; Srijanto, Bernadeta R [ORNL; Collier, Pat [ORNL; Simpson, Michael L [ORNL

2013-01-01T23:59:59.000Z

275

Process and genes for expression and overexpression of active [FeFe] hydrogenases  

DOE Patents [OSTI]

A process for expression of active [FeFe]-hydrogenase in a host organism that does not contain either the structural gene(s) for [FeFe]-hydrogenases and/or homologues for the maturation genes HydE, HydF and HyG, comprising: cloning the structural hydrogenase gene(s) and/or the maturation genes HydE, HydF and HydG from an organisms that contains these genes into expression plasmids; transferring the plasmids into an organism that lacks a native [FeFe]-hydrogenase or that has a disrupted [FeFe]-hydrogenase and culturing it aerobically; and inducing anaerobiosis to provide [FeFe] hydrogenase biosynthesis and H?2#191 production.

Seibert, Michael; King, Paul W; Ghirardi, Maria Lucia; Posewitz, Matthew C; Smolinski, Sharon L

2014-09-16T23:59:59.000Z

276

Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification  

SciTech Connect (OSTI)

The study of gene family members has been aided by the isolation of related genes on the basis of DNA homology. The authors have adapted the polymerase chain reaction to screen animal genomes very rapidly and reliably for likely gene family members. Using conserved amino acid sequences to design degenerate oligonucleotide primers, they have shown that the genome of the nematode Caenorhabditis elegans contains sequences homologous to many Drosophila genes involved in pattern formation, including the segment polarity gene wingless (vertebrate int-1), and homeobox sequences characteristic of the Antennapedia, engrailed, and paired families. In addition, they have used this method to show that C. elegans contains at least five different sequences homologous to genes in the tyrosine kinase family. Lastly, they have isolated six potassium channel sequences from humans, a result that validates the utility of the method with large genomes and suggests that human potassium channel gene diversity may be extensive.

Kamb, A.; Weir, M.; Rudy, B.; Varmus, H.; Kenyon, C. (Univ. of California, San Francisco (USA))

1989-06-01T23:59:59.000Z

277

Could the gene coding for human uteroglobin (clara cell 10 kDa protein) be a candidate gene for atopy?  

SciTech Connect (OSTI)

It has been proposed that human immune response to allergens is genetically determined. Most of these allergic responses are directed to environmental proteins and are mediated by immunoglobulin E (IgE). These allergic disorders (eg. allergic asthma) are commonly known as atopy. IgE activates phospholipase A{sub 2} (PLA{sub 2}) which hydrolyzes cell membrane phospholipids generating free fatty acids, such as arachidonic acid (AA). AA is utilized as the substrate for the generation of pro-inflammatory eicosanoids and platelet activating factor (PAF). These agents can cause inflammation as well as bronchoconstriction, hallmarks of asthma. IgE-induced mast cell degranulation and accumulation of basophils and eosinophils in the lung are also characteristic immunological processes commonly found in atopic asthma. Recent investigations suggest that a group I PLA{sub 2} may be associated with the secretory granules of these cells. An inverse relationship between the levels of eicosanoids and hUG has been found in the nasopharyngeal lavage fluid of children with viral infections of the upper respiratory tract, often a precipitating factor in asthma. Results of genetic linkage studies mapped a putative atopy gene in human chromosome 11q{sup 13}, the same region in which we localized the hUG gene. Moreover, a genetic linkage between atopic IgE responses and chromosome 11q{sup 13} has been reported. In addition, hUG is: (i) a potent inhibitor of PLA{sub 2} activity, (ii) a potent antiinflammatory/immunomodulatory and antichemotactic protein and has a hitherto undetermined receptor-mediated activity. Taken together, these findings suggest that a mutation either in the hUG or its receptor genes may manifest symptoms characteristic of atopy. Hence, we raise the question whether hUG is a candidate gene for this disease.

Mukherjee, A.B.; Peri, A.; Miele, L. [SDG, Bethesda, MD (United States)] [and others

1994-09-01T23:59:59.000Z

278

Effects of alien and intraspecies cytoplasms on manifestation of nuclear genes for wheat resistance to brown rust: II. Specificity of cytoplasm influence on different Lr genes  

SciTech Connect (OSTI)

Specificity of expression of the major nuclear genes Lr to two brown rust clones in hybrids with the same maternal cytoplasm was analyzed. It was evaluated by a resistant: susceptible ratio in the F{sub 2}. Reciprocal hybrids were obtained from the cross between the progeny of homozygous susceptible plants of the cultivar Penjamo 62 and its alloplasmatic lines carrying cytoplasms of Triticum dicoccoides var. fulvovillosum, Aegilops squarrosa var. typical, Agropyron trichophorum, and isogenic lines of the cultivar Thatcher (Th) with the Lr1, Lr9, Lr15, and Lr19 genes. It was shown that the effect of the Lr1 gene in the cytoplasm of cultivar Thatcher and in eu-, and alloplasmatic forms of Penjamo 62 was less expressed than that of other Lr genes. Cytoplasm of the alloplasmatic line (dicoccoides)-Penjamo 62 was the only exception: in the F{sub 2}, hybrids with Th (Lr1) had a higher yield of resistant forms than those with Th (Lr15). In the hybrid combinations studied, expression and/or transmission of the Lr19 gene was more significant than that of other genes. This gene had no advantages over Lr15 and Lr19 only in cytoplasm of the alloplasmatic line (squarrosa)-Penjamo 62. In certain hybrid cytoplasms, the display of the Lr1, Lr15, and Lr19 genes, in contrast to Lr9, varied with the virulence of the pathogen clones. 15 refs., 5 tabs.

Voluevich, E.A.; Buloichik, A.A.; Palilova, A.N. [Institute of Genetics and Cytology, Minsk (Belarus)

1995-04-01T23:59:59.000Z

279

[CANCER RESEARCH 64, 53905397, August 1, 2004] Effective Gene-Viral Therapy for Telomerase-Positive Cancers by Selective  

E-Print Network [OSTI]

-Positive Cancers by Selective Replicative-Competent Adenovirus Combining with Endostatin Gene Qi Zhang,1 Mingming

Tian, Weidong

280

The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion  

SciTech Connect (OSTI)

The ascomycetous fungus Nectria haematococca, (asexual name Fusarium solani), is a member of a group of .50 species known as the"Fusarium solani species complex". Members of this complex have diverse biological properties including the ability to cause disease on .100 genera of plants and opportunistic infections in humans. The current research analyzed the most extensively studied member of this complex, N. haematococca mating population VI (MPVI). Several genes controlling the ability of individual isolates of this species to colonize specific habitats are located on supernumerary chromosomes. Optical mapping revealed that the sequenced isolate has 17 chromosomes ranging from 530 kb to 6.52 Mb and that the physical size of the genome, 54.43 Mb, and the number of predicted genes, 15,707, are among the largest reported for ascomycetes. Two classes of genes have contributed to gene expansion: specific genes that are not found in other fungi including its closest sequenced relative, Fusarium graminearum; and genes that commonly occur as single copies in other fungi but are present as multiple copies in N. haematococca MPVI. Some of these additional genes appear to have resulted from gene duplication events, while others may have been acquired through horizontal gene transfer. The supernumerary nature of three chromosomes, 14, 15, and 17, was confirmed by their absence in pulsed field gel electrophoresis experiments of some isolates and by demonstrating that these isolates lacked chromosome-specific sequences found on the ends of these chromosomes. These supernumerary chromosomes contain more repeat sequences, are enriched in unique and duplicated genes, and have a lower G+C content in comparison to the other chromosomes. Although the origin(s) of the extra genes and the supernumerary chromosomes is not known, the gene expansion and its large genome size are consistent with this species' diverse range of habitats. Furthermore, the presence of unique genes on supernumerary chromosomes might account for individual isolates having different environmental niches.

Coleman, J.J.; Rounsley, S.D.; Rodriguez-Carres, M.; Kuo, A.; Wasmann, C.c.; Grimwood, J.; Schmutz, J.; Taga, M.; White, G.J.; Zhuo, S.; Schwartz, D.C.; Freitag, M.; Ma, L.-J.; Danchin, E.G.J.; Henrissat, B.; Cutinho, P.M.; Nelson, D.R.; Straney, D.; Napoli, C.A.; Baker, B.M.; Gribskov, M.; Rep, M.; Kroken, S.; Molnar, I.; Rensing, C.; Kennell, J.C.; Zamora, J.; Farman, M.L.; Selker, E.U.; Salamov, A.; Shapiro, H.; Pangilinan, J.; Lindquist, E.; Lamers, C.; Grigoriev, I.V.; Geiser, D.M.; Covert, S.F.; Temporini, S.; VanEtten, H.D.

2009-04-20T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
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they are not comprehensive nor are they the most current set.
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to obtain the most current and comprehensive results.


281

Prolactin receptor and signal transduction to milk protein genes  

SciTech Connect (OSTI)

After cloning of the mammary gland prolactin (PRL) receptor cDNA, a functional assay was established using co-transfection of PRL receptor cDNA together with a milk protein promoter/chloramphenicol acetyl transferase (CAT) construct in Chinese hamster ovary (CHO) cells. Different mutants of the PRL receptor were tested in this CAT assay to delimit the domains in the receptor necessary for signal transduction to milk protein genes. In CHO cells stably transfected with PRL receptor cDNA, high numbers of PRL receptor are expressed. By metabolic labeling and immunoprecipitation, expressed PRL receptor was identified as a single species of 100 kDa. Using these cells, we analyzed the effects of PRL on intracellular free Ca{sup ++} concentration. PRL stimulates Ca{sup ++} entry and induces secondary Ca{sup ++} mobilization. The entry of Ca{sup ++} is a result of an increase in K{sup +} conductance that hyperpolarizes the membranes. We have also analyzed tyrosine phosphorylation induced by PRL. In CHO cells stably transfected with PRL receptor cDNA, PRL induced a very rapid and transient tyrosine phosphorylation of a 100-kDa protein which is most probably the PRL receptor. The same finding was obtained in mammary membranes after PRL injection to lactating rabbits. Whereas tyrosine kinase inhibitors genistein and lavendustin were without effect, PRL stimulation of milk protein gene promoters was partially inhibited by 2 {mu}M herbimycin in CHO cells co-transfected with PRL receptor cDNA and the {Beta} lactoglobulin CAT construct. Taken together these observations indicate that the cytoplasmic domain of the PRL receptor interacts with one or several tyrosine kinases, which may represent early postreceptor events necessary for PRL signal transduction to milk protein genes. 14 refs., 4 figs.

Djiane, J.; Daniel, N.; Bignon, C. [Unite d`Endocrinologie Moleculaire, Jouy en Josas (France)] [and others

1994-06-01T23:59:59.000Z

282

Imaging gene expression in real-time using aptamers  

SciTech Connect (OSTI)

Signal transduction pathways are usually activated by external stimuli and are transient. The downstream changes such as transcription of the activated genes are also transient. Real-time detection of promoter activity is useful for understanding changes in gene expression, especially during cell differentiation and in development. A simple and reliable method for viewing gene expression in real time is not yet available. Reporter proteins such as fluorescent proteins and luciferase allow for non-invasive detection of the products of gene expression in living cells. However, current reporter systems do not provide for real-time imaging of promoter activity in living cells. This is because of the long time period after transcription required for fluorescent protein synthesis and maturation. We have developed an RNA reporter system for imaging in real-time to detect changes in promoter activity as they occur. The RNA reporter uses strings of RNA aptamers that constitute IMAGEtags (Intracellular MultiAptamer GEnetic tags), which can be expressed from a promoter of choice. The tobramycin, neomycin and PDC RNA aptamers have been utilized for this system and expressed in yeast from the GAL1 promoter. The IMAGEtag RNA kinetics were quantified by RT-qPCR. In yeast precultured in raffinose containing media the GAL1 promoter responded faster than in yeast precultured in glucose containing media. IMAGEtag RNA has relatively short half-life (5.5 min) in yeast. For imaging, the yeast cells are incubated with their ligands that are labeled with fluorescent dyes. To increase signal to noise, ligands have been separately conjugated with the FRET (Frster resonance energy transfer) pairs, Cy3 and Cy5. With these constructs, the transcribed aptamers can be imaged after activation of the promoter by galactose. FRET was confirmed with three different approaches, which were sensitized emission, acceptor photobleaching and donor lifetime by FLIM (fluorescence lifetime imaging microscopy). Real-time transcription was measured by FLIM-FRET, which was detected by the decrease in donor lifetime resulting from ligand binding to IMAGEtags that were newly synthesized from the activated GAL1 promoter. The FRET signal was specific for transcribed IMAGEtags.

Shin, Il Chung

2011-12-13T23:59:59.000Z

283

Deciphering c-MYC-regulated genes in two distinct tissues  

E-Print Network [OSTI]

of Warwick, CV4 7AL, UK Full list of author information is available at the end of the article Robson et al. BMC Genomics 2011, 12:476 http://www.biomedcentral.com/1471-2164/12/476 2011 Robson et al; licensee BioMed Central Ltd. This is an Open Access... ] and subtractive hybridization [25]. It has been hypothesized that MYC may have the potential to regu- late up to 15% of the entire genome [26], leading to it being described as a master regulator of gene expression. Regulatable transgenic mouse models have...

Robson, Samuel C; Ward, Lesley; Brown, Helen; Turner, Heather; Hunter, Ewan; Pelengaris, Stella; Khan, Michael

2011-09-30T23:59:59.000Z

284

Ayuda:Imágenes | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 NoPublic Utilities Address: 160 EastMaine: EnergyAustin Energy Place: TexasAvoyelles Parish,Ayuda:EcuacionesImágenes

285

Gene Geracao Eolica Do Nordeste | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartmentAUDIT REPORTOpen EnergyBoard" form. To createResearch Groups JumpGenDriveGene

286

Sandia National Laboratories: GeneSiC Semiconductor  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -theErik Spoerke SSLS Exhibit at Explora MuseumFloatingFrontGTO Sandia WinsGeneSiC

287

Sex-based differences in gene expression in hippocampus following postnatal lead exposure  

SciTech Connect (OSTI)

The influence of sex as an effect modifier of childhood lead poisoning has received little systematic attention. Considering the paucity of information available concerning the interactive effects of lead and sex on the brain, the current study examined the interactive effects of lead and sex on gene expression patterns in the hippocampus, a structure involved in learning and memory. Male or female rats were fed either 1500 ppm lead-containing chow or control chow for 30 days beginning at weaning.Blood lead levels were 26.7 {+-} 2.1 {mu}g/dl and 27.1 {+-} 1.7 {mu}g/dl for females and males, respectively. The expression of 175 unique genes was differentially regulated between control male and female rats. A total of 167 unique genes were differentially expressed in response to lead in either males or females. Lead exposure had a significant effect without a significant difference between male and female responses in 77 of these genes. In another set of 71 genes, there were significant differences in male vs. female response. A third set of 30 genes was differentially expressed in opposite directions in males vs. females, with the majority of genes expressed at a lower level in females than in males. Highly differentially expressed genes in males and females following lead exposure were associated with diverse biological pathways and functions. These results show that a brief exposure to lead produced significant changes in expression of a variety of genes in the hippocampus and that the response of the brain to a given lead exposure may vary depending on sex. - Highlights: > Postnatal lead exposure has a significant effect on hippocampal gene expression patterns. > At least one set of genes was affected in opposite directions in males and females. > Differentially expressed genes were associated with diverse biological pathways.

Schneider, J.S., E-mail: jay.schneider@jefferson.edu; Anderson, D.W.; Sonnenahalli, H.; Vadigepalli, R.

2011-10-15T23:59:59.000Z

288

Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1? gene expression in pancreatic islet ?-cells  

SciTech Connect (OSTI)

Highlights: Arnt mRNA expressed in a circadian manner in mouse pancreatic islets. Expressions of Dbp and Arnt damped in the islets of a diabetic model mouse. DBP and E4BP4 regulate Arnt promoter activity by direct binding. Arnt may have a role in connecting circadian rhythm and metabolism. -- Abstract: Aryl hydrocarbon receptor nuclear translocator (ARNT)/hypoxia inducible factor-1? (HIF-1?) has emerged as a potential determinant of pancreatic ?-cell dysfunction and type 2 diabetes in humans. An 82% reduction in Arnt expression was observed in islets from type 2 diabetic donors as compared to non-diabetic donors. However, few regulators of Arnt expression have been identified. Meanwhile, disruption of the clock components CLOCK and BMAL1 is known to result in hypoinsulinemia and diabetes, but the molecular details remain unclear. In this study, we identified a novel molecular connection between Arnt and two clock-controlled output genes, albumin D-element binding protein (Dbp) and E4 binding protein 4 (E4bp4). By conducting gene expression studies using the islets of Wfs1{sup ?/?} A{sup y}/a mice that develop severe diabetes due to ?-cell apoptosis, we demonstrated clock-related gene expressions to be altered in the diabetic mice. Dbp mRNA decreased by 50%, E4bp4 mRNA increased by 50%, and Arnt mRNA decreased by 30% at Zeitgever Time (ZT) 12. Mouse pancreatic islets exhibited oscillations of clock gene expressions. E4BP4, a D-box negative regulator, oscillated anti-phase to DBP, a D-box positive regulator. We also found low-amplitude circadian expression of Arnt mRNA, which peaked at ZT4. Over-expression of DBP raised both mRNA and protein levels of ARNT in HEK293 and MIN6 cell lines. Arnt promoter-driven luciferase reporter assay in MIN6 cells revealed that DBP increased Arnt promoter activity by 2.5-fold and that E4BP4 competitively inhibited its activation. In addition, on ChIP assay, DBP and E4BP4 directly bound to D-box elements within the Arnt promoter in MIN6 cells. These results suggest that in mouse pancreatic islets mRNA expression of Arnt fluctuates significantly in a circadian manner and that the down-regulation of Dbp and up-regulation E4bp4 contribute to direct suppression of Arnt expression in diabetes.

Nakabayashi, Hiroko; Ohta, Yasuharu, E-mail: yohta@yamaguchi-u.ac.jp; Yamamoto, Masayoshi; Susuki, Yosuke; Taguchi, Akihiko; Tanabe, Katsuya; Kondo, Manabu; Hatanaka, Masayuki; Nagao, Yuko; Tanizawa, Yukio, E-mail: tanizawa@yamaguchi-u.ac.jp

2013-05-03T23:59:59.000Z

289

Recognizing genes and other components of genomic structure  

SciTech Connect (OSTI)

The Aspen Center for Physics (ACP) sponsored a three-week workshop, with 26 scientists participating, from 28 May to 15 June, 1990. The workshop, entitled Recognizing Genes and Other Components of Genomic Structure, focussed on discussion of current needs and future strategies for developing the ability to identify and predict the presence of complex functional units on sequenced, but otherwise uncharacterized, genomic DNA. We addressed the need for computationally-based, automatic tools for synthesizing available data about individual consensus sequences and local compositional patterns into the composite objects (e.g., genes) that are -- as composite entities -- the true object of interest when scanning DNA sequences. The workshop was structured to promote sustained informal contact and exchange of expertise between molecular biologists, computer scientists, and mathematicians. No participant stayed for less than one week, and most attended for two or three weeks. Computers, software, and databases were available for use as electronic blackboards'' and as the basis for collaborative exploration of ideas being discussed and developed at the workshop. 23 refs., 2 tabs.

Burks, C. (Los Alamos National Lab., NM (USA)); Myers, E. (Arizona Univ., Tucson, AZ (USA). Dept. of Computer Science); Stormo, G.D. (Colorado Univ., Boulder, CO (USA). Dept. of Molecular, Cellular and Developmental Biology)

1991-01-01T23:59:59.000Z

290

Transcript levels and synthesis of photosystem II components in cyanobacterial mutants with inactivated photosystem II genes  

SciTech Connect (OSTI)

After interruption or deletion of the photosystem II genes psbB, psbC, and psbD in the cyanobacterium Synechocystis sp. PCC 6803, thylakoids from such mutants were found to be depleted in a number of photosystem II proteins in addition to those for which the gene(s) had been inactivated. Transcript levels of photosystem II genes were measured and protein pulse-labeling was carried out to determine the reason for this effect. Transcripts of all photosystem II genes except the inactivated one(s) were found to be present in the various mutants. In certain cases, inactivation of one photosystem II gene led to overexpression of another. Protein pulse-labeling experiments using {sup 35}S-methionine, in which not only the rapidly turing over D1 protein but also D2, CP43, and CP47 appear to be preferentially labeled, showed that the mutants studied synthesize the D1 protein as well as other photosystem II proteins whose genes were not inactivated. The fact that, in the various mutants, photosystem II proteins for which the gene is not inactivated are synthesized but do not accumulate in the thylakoid indicates that the psbB, psbC, and psbD gene products are all required for a stable assembly of the photosystem II complex.

Jiujiang Yu; Vermaas, W.F.J. (Arizona State Univ., Tempe (United States))

1990-04-01T23:59:59.000Z

291

E-Print Network 3.0 - archaeal amoa genes Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

genes involved in its transformations Source: Center for Coastal Margin Observation and Prediction (CMOP) Collection: Environmental Sciences and Ecology ; Geosciences 18...

292

E-Print Network 3.0 - avpr2 gene mutations Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

; Biology and Medicine 3 Current Pharmacogenomics, 2005, 3, 000-000 1 1570-160305 50.00+.00 2005 Bentham Science Publishers Ltd. Summary: vasopressin receptor gene...

293

E-Print Network 3.0 - analyzing time-series gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

series in terms of number... gene networks from time series include boolean network models, 5 Correlation Metric Construction, 6... - constructed time ... Source: D'haeseleer,...

294

E-Print Network 3.0 - activator inhibitor-1 gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

activator inhibitor-1 gene Page: << < 1 2 3 4 5 > >> 1 EdinburghStanford TREC 2003 Genomics Track: Notebook Paper Summary: -dependent kinase inhibitor 1a'' ''dna synthesis...

295

E-Print Network 3.0 - alter legume gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Biology and Medicine 2 Meeting Report Legumes as a Model Plant Family. Genomics for Food and Summary: biochemical genes will be mapped across major crop legumes in...

296

E-Print Network 3.0 - alphaviruses gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1994. The alphaviruses: gene... of Marine Mammals: a New Alphavirus Isolated from the Elephant Seal Louse, Lepidophthirus macrorhini MAY LA... Accepted 29 January 2001 A novel...

297

E-Print Network 3.0 - alstrom syndrome gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Powered by Explorit Topic List Advanced Search Sample search results for: alstrom syndrome gene Page: << < 1 2 3 4 5 > >> 1 LIFE SCIENCE NEWSPublished by the Institute of...

298

ai-ciii-aiv gene cluster: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the application of a novel clustering algorithm, Super-Paramagnetic Clustering (SPC) to analysis of gene expression profiles that were generated recently during a study of...

299

E-Print Network 3.0 - alkane hydroxylase gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

gene. Sequence and expression... . In Vivo ... Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology Collection:...

300

E-Print Network 3.0 - amplified gene encoding Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to normal cells Summary: amplify the genes for photosynthesis in the presence of dye-labeled nucleotides and incubate the products... . I cannot make a reasonable guess....

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
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We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Natural epigenetic polymorphisms lead to intraspecific variation in Arabidopsis gene imprinting  

E-Print Network [OSTI]

Imprinted gene expression occurs during seed development in plants and is associated with differential DNA methylation of parental alleles, particularly at proximal transposable elements (TEs). Imprinting variability could ...

Pignatta, Daniela

302

E-Print Network 3.0 - aluminum tolerance genes Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

expression and soil aluminum tolerance Summary: to exhibit enhanced tolerance to Al, alfalfa was engineered by introducing the CS gene controlled... that were more...

303

E-Print Network 3.0 - approaches gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

D: Knowledge Questions 1. You are investigating the changes in gene expression in cancer cells compared to normal cells Summary: Appendix D: Knowledge Questions 1. You are...

304

E-Print Network 3.0 - analyse gene patterns Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nebraska-Lincoln Collection: Environmental Sciences and Ecology ; Biology and Medicine 31 Identification of a nematode chemosensory gene family Summary: - ical clustering patterns....

305

E-Print Network 3.0 - a-amylase inhibitor gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interaction of monoterpenes Summary: Molecular phylogenetic analysis of the potato a-amylase gene family reveals clustering into two distinct... - mediated tuber bud...

306

E-Print Network 3.0 - aphid resistance gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

gene confers resistance in tomato to certain clones of Macrosiphum euphorbiae (potato aphid), two... aphids progress through different feeding stages. Interestingly, the...

307

E-Print Network 3.0 - auto-regulation increase gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and feed-forward motifs. Figure 2 illustrates the automatic... 100 to N 104 genes. Code is available online and from the authors. 1 Introduction ... Source: Oxford,...

308

Accelerated Gene Evolution and Subfunctionalization in the Pseudotetraploid Frog Xenopus Laevis  

E-Print Network [OSTI]

Accelerated gene evolution and subfunctionalization in thethese triplets reveals accelerated evolution or relaxationbeen proposed to exhibit accelerated [31] or slowed [32

Hellsten, Uffe; Khokha, Mustafa K.; Grammar, Timothy C.; Harland, Richard M.; Richardson, Paul; Rokhsar, Daniel S.

2007-01-01T23:59:59.000Z

309

E-Print Network 3.0 - acvr1 gene mutation Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Emerging from an increasing number of mouse gene knockout, dominant... of cytoplasmic Stat-5 and translocation of Stat-5-phosphate to the nucleus for promo- tion of milk...

310

E-Print Network 3.0 - acid gene cluster Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The most common method for analyzing gene expression data is ... Source: Friedman, Nir - School of Computer Science and Engineering, Hebrew University of Jerusalem Collection:...

311

E-Print Network 3.0 - alpha gene variants Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1724, Detroit, June 2005. c 2005 Association for Computational Linguistics Summary: .2 Generating orthographic variants Our previous work on gene and protein name synonyms...

312

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents [OSTI]

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2011-10-04T23:59:59.000Z

313

E-Print Network 3.0 - altered ovarian gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: altered ovarian gene Page: << < 1 2 3 4 5 > >> 1 Ovarian cancer is the most lethal cause of death among the gynecological cancers. Conventional...

314

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents [OSTI]

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2008-09-30T23:59:59.000Z

315

E-Print Network 3.0 - atctl2 gene enhances Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: Biologists Mutation of a Chitinase-Like Gene Causes Ectopic Deposition of Lignin, Aberrant Cell Shapes... growth and development, but no muta- tions in chitinase-like...

316

E-Print Network 3.0 - automated eukaryotic gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

origins. The results... relationships for eukaryotic genes ... Source: Cotton, James - School of Biological and Chemical Sciences, Queen Mary, University of London...

317

Causal Gene Network Inference from Genetical Genomics Experiments via Structural Equation Modeling.  

E-Print Network [OSTI]

??The goal of this research is to construct causal gene networks for genetical genomics experiments using expression Quantitative Trait Loci (eQTL) mapping and Structural Equation (more)

Liu, Bing

2006-01-01T23:59:59.000Z

318

Identification of cis-regulatory elements in mouse Mab21l2 gene by comparative genomics.  

E-Print Network [OSTI]

??The mab-21 gene was first identified in Caenorhabditis elegans as a critical component required for sensory organ identity determination. Mab21 homologs are highly conserved from (more)

Shek, Kim Fung

2010-01-01T23:59:59.000Z

319

Functional gene screening in embryonic stem cell implicates Wnt antagonism in neural differentiation.  

E-Print Network [OSTI]

The multilineage differentiation capacity of mouse embryonic stem (ES) cells offers a potential testing platform for gene products that mediate mammalian lineage determination and cellular specialization. Identification ...

Aubert, Jerome; Dunstan, Hannah; Chambers, Ian; Smith, Austin G

2002-01-01T23:59:59.000Z

320

E-Print Network 3.0 - acute phase gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

function and metabolism. Recent studies demonstrate that acute... proton nuclear magnetic resonance in mice subjected to acute CR. Liver and muscle showed increased gene... tissues...

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
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to obtain the most current and comprehensive results.


321

E-Print Network 3.0 - autophagy genes protect Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

that starvation induced the tran- scription of several autophagy genes... ). To test whether TFEB regulated the expres- sion of autophagy ... Source: Gleeson, Joseph G. -...

322

Wide-cross whole-genome radiation hybrid (WWRH) mapping and identification of cold-responsive genes using oligo-gene microarray analysis in cotton  

E-Print Network [OSTI]

that the WWRH mapping method can be used to map the cotton genome, and that this method complements traditional linkage mapping approaches. The second part of this research focused on the identification of cold-responsive genes using spotted oligo...

Gao, Wenxiang

2005-02-17T23:59:59.000Z

323

Human KZNF Gene Catalog - A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

Kruppel-type zinc finger (ZNF) motifs are prevalent components of transcription factor proteins in all eukaryotes. KRAB-ZNF proteins, in which a potent repressor domain is attached to a tandem array of DNA-binding zinc-finger motifs, are specific to tetrapod vertebrates and represent the largest class of ZNF proteins in mammals. To define the full repertoire of human KRAB-ZNF proteins, we searched the genome sequence for key motifs and then constructed and manually curated gene models incorporating those sequences. The resulting gene catalog contains 423 KRAB-ZNF protein-coding loci, yielding alternative transcripts that altogether predict at least 742 structurally distinct proteins. Active rounds of segmental duplication, involving single genes or larger regions and including both tandem and distributed duplication events, have driven the expansion of this mammalian gene family. Comparisons between the human genes and ZNF loci mined from the draft mouse, dog, and chimpanzee genomes not only identified 103 KRAB-ZNF genes that are conserved in mammals but also highlighted a substantial level of lineage-specific change; at least 136 KRAB-ZNF coding genes are primate specific, including many recent duplicates. KRAB-ZNF genes are widely expressed and clustered genes are typically not coregulated, indicating that paralogs have evolved to fill roles in many different biological processes. To facilitate further study, we have developed a Web-based public resource with access to gene models, sequences, and other data, including visualization tools to provide genomic context and interaction with other public data sets. [This abstract was copied from: S Huntley, DM Baggott, AT Hamilton, M Tran-Gyamfi, S Yang, J Kim, L Gordon, E Branscomb, and L Stubbs. 2006. A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors, Genome Research 16(5):669 - 677] The website provides the ability to search the online catalog by genomic coordinates, name, locus type, and motifs, to utilize a graphical browser and to download data files.

Huntley, S; Baggott, D.M.; Hamilton, A.T.; Tran-Gyamfi, M.; Yang, S.; Kim, J.; Gordon, L.; Branscomb, E.; Stubbs, L.

324

Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus  

DOE Patents [OSTI]

The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.

Dai, Ziyu (Richland, WA); Lasure, Linda L. (Fall City, WA); Magnuson, Jon K. (Pasco, WA)

2008-11-11T23:59:59.000Z

325

Isolated Fungal Promoters and Gene Transcription Terminators and Methods of Protein and Chemical Production in a Fungus  

DOE Patents [OSTI]

The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.

Dai, Ziyu (Richland, WA); Lasure, Linda L. (Fall City, WA); Magnuson, Jon K. (Pasco, WA)

2008-11-11T23:59:59.000Z

326

Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus  

DOE Patents [OSTI]

The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.

Dai, Ziyu; Lasure, Linda L; Magnuson, Jon K

2014-05-27T23:59:59.000Z

327

LAMMPS strong scaling performance optimization on Blue Gene/Q  

SciTech Connect (OSTI)

LAMMPS "Large-scale Atomic/Molecular Massively Parallel Simulator" is an open-source molecular dynamics package from Sandia National Laboratories. Significant performance improvements in strong-scaling and time-to-solution for this application on IBM's Blue Gene/Q have been achieved through computational optimizations of the OpenMP versions of the short-range Lennard-Jones term of the CHARMM force field and the long-range Coulombic interaction implemented with the PPPM (particle-particle-particle mesh) algorithm, enhanced by runtime parameter settings controlling thread utilization. Additionally, MPI communication performance improvements were made to the PPPM calculation by re-engineering the parallel 3D FFT to use MPICH collectives instead of point-to-point. Performance testing was done using an 8.4-million atom simulation scaling up to 16 racks on the Mira system at Argonne Leadership Computing Facility (ALCF). Speedups resulting from this effort were in some cases over 2x.

Coffman, Paul; Jiang, Wei; Romero, Nichols A.

2014-11-12T23:59:59.000Z

328

Use of NAP gene to manipulate leaf senescence in plants  

DOE Patents [OSTI]

The present invention discloses transgenic plants having an altered level of NAP protein compared to that of a non-transgenic plant, where the transgenic plants display an altered leaf senescence phenotype relative to a non-transgenic plant, as well as mutant plants comprising an inactivated NAP gene, where mutant plants display a delayed leaf senescence phenotype compared to that of a non-mutant plant. The present invention also discloses methods for delaying leaf senescence in a plant, as well as methods of making a mutant plant having a decreased level of NAP protein compared to that of a non-mutant plant, where the mutant plant displays a delayed leaf senescence phenotype relative to a non-mutant plant. Methods for causing precocious leaf senescence or promoting leaf senescence in a plant are also disclosed. Also disclosed are methods of identifying a candidate plant suitable for breeding that displays a delayed leaf senescence and/or enhanced yield phenotype.

Gan, Susheng; Guo, Yongfeng

2013-04-16T23:59:59.000Z

329

Recombinant cells that highly express chromosomally-integrated heterologous genes  

DOE Patents [OSTI]

Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol.

Ingram, Lonnie O. (Gainesville, FL); Ohta, Kazuyoshi (Gainesville, FL); Wood, Brent E. (Gainesville, FL)

2000-08-22T23:59:59.000Z

330

Recombinant cells that highly express chromosomally-integrated heterologous genes  

DOE Patents [OSTI]

Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol. 13 figs.

Ingram, L.O.; Ohta, Kazuyoshi; Wood, B.E.

1998-10-13T23:59:59.000Z

331

Recombinant cells that highly express chromosomally-integrated heterologous genes  

DOE Patents [OSTI]

Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol.

Ingram, Lonnie O. (Gainesville, FL); Ohta, Kazuyoshi (Gainesville, FL); Wood, Brent E. (Gainesville, FL)

1998-01-01T23:59:59.000Z

332

Technology development for gene discovery and full-length sequencing  

SciTech Connect (OSTI)

In previous years, with support from the U.S. Department of Energy, we developed methods for construction of normalized and subtracted cDNA libraries, and constructed hundreds of high-quality libraries for production of Expressed Sequence Tags (ESTs). Our clones were made widely available to the scientific community through the IMAGE Consortium, and millions of ESTs were produced from our libraries either by collaborators or by our own sequencing laboratory at the University of Iowa. During this grant period, we focused on (1) the development of a method for preferential cloning of tissue-specific and/or rare transcripts, (2) its utilization to expedite EST-based gene discovery for the NIH Mouse Brain Molecular Anatomy Project, (3) further development and optimization of a method for construction of full-length-enriched cDNA libraries, and (4) modification of a plasmid vector to maximize efficiency of full-length cDNA sequencing by the transposon-mediated approach. It is noteworthy that the technology developed for preferential cloning of rare mRNAs enabled identification of over 2,000 mouse transcripts differentially expressed in the hippocampus. In addition, the method that we optimized for construction of full-length-enriched cDNA libraries was successfully utilized for the production of approximately fifty libraries from the developing mouse nervous system, from which over 2,500 full-ORF-containing cDNAs have been identified and accurately sequenced in their entirety either by our group or by the NIH-Mammalian Gene Collection Program Sequencing Team.

Marcelo Bento Soares

2004-07-19T23:59:59.000Z

333

Genetic analyses of bovine CARD15, a putative disease resistance gene  

E-Print Network [OSTI]

Through a binding partner the CARD15 gene activates NF-kB, a molecule with a role in the initiation of the inflammatory immune response. The gene is highly conserved in both structure and function in human and mouse and has recently been implicated...

Taylor, Kristen Hawkins

2004-09-30T23:59:59.000Z

334

Beyond Synexpression Relationships: Local Clustering of Time-shifted and Inverted Gene  

E-Print Network [OSTI]

Beyond Synexpression Relationships: Local Clustering of Time-shifted and Inverted Gene Expression an inverted relationship. Here, we propose a new method, which we call local clus- tering, for identifying these time-delayed and inverted relationships. It is related to conventional gene-expression clustering

Yu, Haiyuan

335

The Use of EST Expression Matrixes for the Quality Control of Gene Expression Data  

E-Print Network [OSTI]

for tissue typing and quality control of libraries as small as just a few hundred total ESTs. Furthermore, weThe Use of EST Expression Matrixes for the Quality Control of Gene Expression Data Andrew T Expression Matrixes for the Quality Control of Gene Expression Data. PLoS ONE 7(3): e32966. doi:10

Sheldon, Nathan D.

336

Diagnostic test for prenatal identification of Down's syndrome and mental retardation and gene therapy therefor  

DOE Patents [OSTI]

A a diagnostic test useful for prenatal identification of Down syndrome and mental retardation. A method for gene therapy for correction and treatment of Down syndrome. DYRK gene involved in the ability to learn. A method for diagnosing Down's syndrome and mental retardation and an assay therefor. A pharmaceutical composition for treatment of Down's syndrome mental retardation.

Smith, Desmond J. (Oakland, CA); Rubin, Edward M. (Berkeley, CA)

2000-01-01T23:59:59.000Z

337

The investigation of controlled release microchips, nanoparticles, and sirna for gene therapy in tissue engineering applications  

E-Print Network [OSTI]

to a decrease in viability of the cells. It was also noted that the method of cell death is likely to be apoptosis. To confirm the efficacy of gene therapy through transfection, the transfection of the serum response factor (SRF) gene plasmid DNA...

Chern, Christina

2009-05-15T23:59:59.000Z

338

FUNCTIONAL ANNOTATION OF OIL PALM GENES USING AN AUTOMATED BIOINFORMATICS APPROACH FUNCTIONAL ANNOTATION OF OIL PALM  

E-Print Network [OSTI]

FUNCTIONAL ANNOTATION OF OIL PALM GENES USING AN AUTOMATED BIOINFORMATICS APPROACH 35 FUNCTIONAL ANNOTATION OF OIL PALM GENES USING AN AUTOMATED BIOINFORMATICS APPROACH LAURA B WILLIS*; PHILIP A LESSARDBank, and duplicate entries were eliminated by pairwise BLAST searches, resulting in a collection of unique oil palm

Sinskey, Anthony J.

339

Inferring the Evolutionary History of IncP-1 Plasmids Despite Incongruence among Backbone Gene Trees  

E-Print Network [OSTI]

for human health and environmental remediation. Although it is well understood that the accessory genes is expected to produce conflicting gene tree topologies. The main goal of this study was therefore to infer; Sen et al. 2011), streams (Smalla et al. 2006; Akiyama et al. 2010), and waste- water treatment plants

Sullivan, Jack

340

Evolution of Red Algal Plastid Genomes: Ancient Architectures, Introns, Horizontal Gene Transfer, and  

E-Print Network [OSTI]

Evolution of Red Algal Plastid Genomes: Ancient Architectures, Introns, Horizontal Gene Transfer, Station Biologique, Roscoff, France Abstract Red algae have the most gene-rich plastid genomes known across all available red algal plastid genomes we show they all share a highly compact and slowly

Martone, Patrick T.

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

The Role of the Bcl-X Gene as a Tumor Supressor  

E-Print Network [OSTI]

as a tumor suppressor in certain types of cancers (e.g. breast cancer) is the gene Bcl-x. I seek to determine if Bcl-x is an effective tumor suppressor in hopes that it may be used in gene targeting for treating breast cancer. The methods of my...

McCorvey, Farah

2007-09-17T23:59:59.000Z

342

Seamless Correction of the Sickle Cell Disease Mutation of the HBB Gene in Human Induced  

E-Print Network [OSTI]

Seamless Correction of the Sickle Cell Disease Mutation of the HBB Gene in Human Induced ABSTRACT: Sickle cell disease (SCD) is the most common human genetic disease which is caused by a single effector nucleases; induced pluripotent stem cells; piggyBac transposon; sickle cell disease; gene therapy

Zhao, Huimin

343

ATLAS on the BlueGene/L Preliminary Results Keith Seymour Haihang You Jack Dongarra  

E-Print Network [OSTI]

ATLAS on the BlueGene/L ­ Preliminary Results Keith Seymour Haihang You Jack Dongarra Department The goal of this work is to use ATLAS to produce a tuned linear algebra library for the BlueGene/L, while of the machine present a few difficulties for a straightforward port of ATLAS. The compute nodes themselves

Dongarra, Jack

344

Gene expression divergence and nucleotide differentiation between males of different color morphs and mating  

E-Print Network [OSTI]

Gene expression divergence and nucleotide differentiation between males of different color morphs sequencing, it is possible to obtain data on both nucleotide sequence variation and gene expression. We have between males, but many genetic markers showed nucleotide differentiation between different color morphs

345

Pigment-cell-specific genes from fibroblasts are transactivated after chromosomal transfer into melanoma cells  

SciTech Connect (OSTI)

Human and mouse fibroblast chromosomes carrying tyrosinase or b-locus genes were introduced, by microcell hybridization, into pigmented Syrian hamster melanoma cells, and the microcell hybrids were tested for transactivation of the fibroblast tyrosinase and b-locus genes. By using species-specific PCR amplification to distinguish fibroblast and melanoma cDNAs, it was demonstrated that the previously silent fibroblast tyrosinase and b-locus genes were transactivated following chromosomal transfer into pigmented melanoma cells. However, transactivation of the mouse fibroblast tyrosinase gene was unstable in microcell hybrid subclones and possibly dependent on a second fibroblast locus that could have segregated in the subclones. This second locus was not necessary for transactivation of the fibroblast b-locus gene, thus demonstrating noncoordinate transactivation of fibroblast tyrosinase and b-locus genes. Transactivation of the fibroblast tyrosinase gene in microcell hybrids apparently is dependent on the absence of a putative fibroblast extinguisher locus for tyrosinase gene expression, which presumably is responsible for the extinction of pigmentation in hybrids between karyotypically complete fibroblasts and melanoma cells. 46 refs., 5 figs., 2 tabs.

Powers, T.P.; Davidson, R.L. [Univ. of Illinois College of Medicine, Chicago, IL (United States); Shows, T.B. [Roswell Park Memorial Inst., Buffalo, NY (United States)

1994-02-01T23:59:59.000Z

346

TECHNICAL ADVANCE The ethanol switch: a tool for tissue-specic gene induction  

E-Print Network [OSTI]

TECHNICAL ADVANCE The ethanol switch: a tool for tissue-speci®c gene induction during plant is a powerful tool for the analysis of gene function during plant development. Here, we report ethanol inducible of an ethanol-regulated transcription factor, ALCR, is restricted to precise domains using speci®c promoters

Murray, J.A.H.

347

Exclusion of Angiotensinogen Gene in Molecular Basis of Human Hypertension: Sibpair Linkage and  

E-Print Network [OSTI]

Exclusion of Angiotensinogen Gene in Molecular Basis of Human Hypertension: Sibpair Linkage. Benjafield,1 Dale R. Nyholt,2 and Brian J. Morris1 * 1 Hypertension Gene Laboratory, Department of Physiology Research Centre, Griffith University, Gold Coast, Queensland, Australia Linkage with essential hypertension

Nyholt, Dale R.

348

Nuclear and Mitochondrial Genes Contain Similar Phylogenetic Signal for Pigeons and Doves (Aves: Columbiformes)  

E-Print Network [OSTI]

Nuclear and Mitochondrial Genes Contain Similar Phylogenetic Signal for Pigeons and Doves (Aves of this assumption in the pigeons and doves (Aves: Columbiformes) by comparing phylog- enies derived from nuclear incongruence between trees derived from the two genes; so, we combined nuclear and mitochondrial data

Clayton, Dale H.

349

Evolutionary Conservation of Expression Profiles Between Human and Mouse Orthologous Genes  

E-Print Network [OSTI]

array-based observations from many individual genes and imply the uselessness of mouse models for studying human genesprofiling technologies became available (Cavalieri, Townsend, and Hartl 2000; Enard et al. 2002; Oleksiak, Churchill all the technologies for producing transcriptome data, the DNA (oligonucleotide or cDNA) microarray

Zhang, Jianzhi

350

Expression of an Arabidopsis vacuolar -pyrophosphatase gene (AVP1) in cotton improves  

E-Print Network [OSTI]

Expression of an Arabidopsis vacuolar H+ -pyrophosphatase gene (AVP1) in cotton improves drought, pro- ton pump, root development, salt stress, transgenic cotton. Summary The Arabidopsis gene AVP1 conditions. Using the same approach, AVP1-expressing cotton plants were created and tested

Blumwald, Eduardo

351

Expression of an Arabidopsis vacuolar -pyrophosphatase gene (AVP1) in cotton improves  

E-Print Network [OSTI]

Expression of an Arabidopsis vacuolar H+ -pyrophosphatase gene (AVP1) in cotton improves drought- ton pump, root development, salt stress, transgenic cotton. Summary The Arabidopsis gene AVP1 encodes-expressing cotton plants were created and tested for their performance under high-salt and reduced irrigation

Blumwald, Eduardo

352

NHR-23 dependent collagen and hedgehog-related genes required for molting  

SciTech Connect (OSTI)

Highlights: {yields} NHR-23 is a critical regulator of nematode development and molting. {yields} The manuscript characterizes the loss-of-function phenotype of an nhr-23 mutant. {yields} Whole genome expression analysis identifies new potential targets of NHR-23. {yields} Hedgehog-related genes are identified as NHR-23 dependent genes. {yields} New link between sterol mediated signaling and regulation by NHR-23 is found. -- Abstract: NHR-23, a conserved member of the nuclear receptor family of transcription factors, is required for normal development in Caenorhabditis elegans where it plays a critical role in growth and molting. In a search for NHR-23 dependent genes, we performed whole genome comparative expression microarrays on both control and nhr-23 inhibited synchronized larvae. Genes that decreased in response to nhr-23 RNAi included several collagen genes. Unexpectedly, several hedgehog-related genes were also down-regulated after nhr-23 RNAi. A homozygous nhr-23 deletion allele was used to confirm the RNAi knockdown phenotypes and the changes in gene expression. Our results indicate that NHR-23 is a critical co-regulator of functionally linked genes involved in growth and molting and reveal evolutionary parallels among the ecdysozoa.

Kouns, Nathaniel A.; Nakielna, Johana; Behensky, Frantisek [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic)] [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic); Krause, Michael W. [Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (United States)] [Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (United States); Kostrouch, Zdenek [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic)] [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic); Kostrouchova, Marta, E-mail: marta.kostrouchova@lf1.cuni.cz [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic)] [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic)

2011-10-07T23:59:59.000Z

353

New Markov Model Approaches to Deciphering Microbial Genome Function and Evolution: Comparative Genomics of Laterally Transferred Genes  

SciTech Connect (OSTI)

Algorithmic methods for gene prediction have been developed and successfully applied to many different prokaryotic genome sequences. As the set of genes in a particular genome is not homogeneous with respect to DNA sequence composition features, the GeneMark.hmm program utilizes two Markov models representing distinct classes of protein coding genes denoted "typical" and "atypical". Atypical genes are those whose DNA features deviate significantly from those classified as typical and they represent approximately 10% of any given genome. In addition to the inherent interest of more accurately predicting genes, the atypical status of these genes may also reflect their separate evolutionary ancestry from other genes in that genome. We hypothesize that atypical genes are largely comprised of those genes that have been relatively recently acquired through lateral gene transfer (LGT). If so, what fraction of atypical genes are such bona fide LGTs? We have made atypical gene predictions for all fully completed prokaryotic genomes; we have been able to compare these results to other "surrogate" methods of LGT prediction.

Borodovsky, M.

2013-04-11T23:59:59.000Z

354

The comparative genomics of salinispora and the distribution and abundance of secondary metabolite genes in marine plankton  

E-Print Network [OSTI]

rplB smpB Comparative genomics Gene gain Gene loss Totalbiology and comparative genomics. BMC Bioinformatics 10(1):Intersection of Evolution and Genomics. Science 300(5626):

Penn, Kevin Matthew

2012-01-01T23:59:59.000Z

355

Using the Cre-loxP system to randomize target gene expression states and generate diverse phenotypes  

E-Print Network [OSTI]

Modifying the expression of multiple genes enables both deeper understanding of their function and the engineering of complex multigenic cellular phenotypes. However, deletion or overexpression of multiple genes is typically ...

Niesner, Bradley (Bradley Joseph)

2013-01-01T23:59:59.000Z

356

A MACHINE LEARNING APPROACH TO QUERY TIME-SERIES MICROARRAY DATA SETS FOR FUNCTIONALLY RELATED GENES USING HIDDEN MARKOV MODELS  

E-Print Network [OSTI]

Microarray technology captures the rate of expression of genes under varying experimental conditions. Genes encode the information necessary to build proteins; proteins used by cellular functions exhibit higher rates of ...

Senf, Alexander J.

2011-02-04T23:59:59.000Z

357

Study Finds that Children with Autism and Gastrointestinal Symptoms Have Altered Expression of Genes Involved in Digestion  

E-Print Network [OSTI]

of Genes Involved in Digestion These changes may also affect the mix of bacteria present in the digestive disturbances have altered expression of genes involved in digestion. These variations may contribute to changes

Salzman, Daniel

358

Feasibility of a predictive model of Hsp70b-activated gene therapy protein expression during ultrasound hyperthermia  

E-Print Network [OSTI]

Gene therapy has been heralded as a possible approach to a variety of diseases and conditions, ranging from cancer and heart disease to blindness and neurodegenerative diseases. However, progress in gene therapy requires ...

Silcox, Christina Elise

2014-01-01T23:59:59.000Z

359

Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights  

E-Print Network [OSTI]

Background: Transcription factors (TFs) play a central role in regulating gene expression by interacting with cis-regulatory DNA elements associated with their target genes. Recent surveys have examined the DNA binding ...

Gordan, Raluca

360

DALTONFULLPAPER DOI: 10.1039/b005612j J. Chem. Soc., Dalton Trans., 2000, 41874191 4187  

E-Print Network [OSTI]

)] (pyz = pyrazine)7 which contains two interpenetrating -Po-like networks, therefore [MII (apo)(N(CN)2-dimensional co-ordination polymers constructed by dimer subunits Bai-Wang Sun, Song Gao,* Bao-Qing Ma, De-ordination polymers have been reported, for example 3-D for MII [N(CN)2]2 (M = Cu, Co, Ni or Mn),2,3 2-D for Zn[N(CN)2

Gao, Song

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

6 Gerlai, R. (2001) Gene targeting: technical confounds and potential solutions in behavioral brain research. Behav. Brain Res. 125,  

E-Print Network [OSTI]

at different alternative splice donor sites of the tyrosinase gene in murine albinism. Genomics 37, 245­248 17

Zhang, ZhaoLei

362

redD as a Reporter for Transcriptional Activity 551 Application of redD, the Transcriptional Activator Gene  

E-Print Network [OSTI]

glaucescens, which encodes tyrosinase (Paget et al., 1994), and the EGFP gene for green-fluorescent protein

Bibb, Mervyn

363

New screening software shows most recent large 16S rRNA gene clone libraries1 contain chimeras.2  

E-Print Network [OSTI]

1 New screening software shows most recent large 16S rRNA gene clone libraries1 contain chimeras.2 3 Running title4 Detecting chimeras within 16S rRNA gene libraries.5 6 Authors7 Kevin E. Ashelford for screening entire 16S rRNA gene2 libraries, of up to 1,000 sequences, for chimeras and other artifacts

Jones, Antonia J.

364

Nucleotide sequence of the 2 matrix protein genes (M1 and M2) of hirame rhabdovirus (HRV),  

E-Print Network [OSTI]

Nucleotide sequence of the 2 matrix protein genes (M1 and M2) of hirame rhabdovirus (HRV), a fish of hirame rhabdovirus (HRV). The M1 protein gene was 684 nucleotides long, encoding 227 amino acids.8% at the nucleotide level and 81.1 and 44.8% at the amino acid level. The M2 protein gene was 582 nucleotides long

Boyer, Edmond

365

Diversification of the monoterpene synthase gene family (TPSb) in Protium, a highly diverse genus of tropical trees  

E-Print Network [OSTI]

such as the exposure to high temperatures or the oxidative damage due to the accumulation of reactive oxygen (Vickers. These genes are part of the highly diverse TPS gene family (Bohlmann et al., 1998; Chen et al., 2011) and playDiversification of the monoterpene synthase gene family (TPSb) in Protium, a highly diverse genus

Fine, Paul V.A.

366

Effects of Acute and Chronic Stress on Immune- and Inflammatory-response Gene Expression in Beef Calves  

E-Print Network [OSTI]

were found in relative quantification for 30 genes in Trial 1 and 36 genes in Trial 2, in which CS calves had greater expression than AS calves (P < 0.047). Fifteen of those genes were common between the two trials with mean treatment differences of RQ...

Terrill, Cooper

2012-02-14T23:59:59.000Z

367

Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate  

SciTech Connect (OSTI)

Pretreatment of mice with the peroxisome proliferator clofibrate (CFB) protects against acetaminophen (APAP)-induced hepatotoxicity. Previous studies have shown that activation of the nuclear peroxisome proliferator activated receptor-alpha (PPAR{alpha}) is required for this effect. The present study utilizes gene expression profile analysis to identify potential pathways contributing to PPAR{alpha}-mediated hepatoprotection. Gene expression profiles were compared between wild type and PPAR{alpha}-null mice pretreated with vehicle or CFB (500 mg/kg, i.p., daily for 10 days) and then challenged with APAP (400 mg/kg, p.o.). Total hepatic RNA was isolated 4 h after APAP treatment and hybridized to Affymetrix Mouse Genome MGU74 v2.0 GeneChips. Gene expression analysis was performed utilizing GeneSpring (registered) software. Our analysis identified 53 genes of interest including vanin-1, cell cycle regulators, lipid-metabolizing enzymes, and aldehyde dehydrogenase 2, an acetaminophen binding protein. Vanin-1 could be important for CFB-mediated hepatoprotection because this protein is involved in the synthesis of cysteamine and cystamine. These are potent antioxidants capable of ameliorating APAP toxicity in rodents and humans. HPLC-ESI/MS/MS analysis of liver extracts indicates that enhanced vanin-1 gene expression results in elevated cystamine levels, which could be mechanistically associated with CFB-mediated hepatoprotection.

Moffit, Jeffrey S. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States); Koza-Taylor, Petra H. [Pfizer, Inc., Groton Laboratories, Molecular and Investigative Toxicology, Groton, CT (United States); Holland, Ricky D. [National Center for Toxicological Research, Division of Systems Toxicology, Jefferson, AR (United States); Thibodeau, Michael S. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States); Beger, Richard D. [National Center for Toxicological Research, Division of Systems Toxicology, Jefferson, AR (United States); Lawton, Michael P. [Pfizer, Inc., Groton Laboratories, Molecular and Investigative Toxicology, Groton, CT (United States); Manautou, Jose E. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States)]. E-mail: jose.manautou@uconn.edu

2007-07-15T23:59:59.000Z

368

Self-assembled pentablock copolymers for selective and sustained gene delivery  

SciTech Connect (OSTI)

The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

Zhang, Bingqi

2011-05-15T23:59:59.000Z

369

Molecular dissection of the roles of the SOD genes in mammalian response to low dose irradiation  

SciTech Connect (OSTI)

It has been long recognized that a significant fraction of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying enzymes may be even more prominent in the case of low-dose, low-LET irradiation, as the majority of genetic damage may be caused by secondary oxidative species. In this study we have attempted to decipher the roles of the superoxide dismutase (SOD) genes, which are responsible for detoxifying the superoxide anions. We used adenovirus vectors to deliver RNA interference (RNAi or siRNA) technology to down-regulate the expression levels of the SOD genes. We have also over-expressed the SOD genes by use of recombinant adenovirus vectors. Cells infected with the vectors were then subjected to low dose ?-irradiation. Total RNA were extracted from the exposed cells and the expression of 9000 genes were profiled by use of cDNA microarrays. The result showed that low dose radiation had clear effects on gene expression in HCT116 cells. Both over-expression and down-regulation of the SOD1 gene can change the expression profiles of sub-groups of genes. Close to 200 of the 9000 genes examined showed over two-fold difference in expression under various conditions. Genes with changed expression pattern belong to many categories that include: early growth response, DNA-repair, ion transport, apoptosis, and cytokine response.

Eric Y. Chuang

2006-08-31T23:59:59.000Z

370

Mapping our genes: The genome projects: How big, how fast  

SciTech Connect (OSTI)

For the past 2 years, scientific and technical journals in biology and medicine have extensively covered a debate about whether and how to determine the function and order of human genes on human chromosomes and when to determine the sequence of molecular building blocks that comprise DNA in those chromosomes. In 1987, these issues rose to become part of the public agenda. The debate involves science, technology, and politics. Congress is responsible for /open quotes/writing the rules/close quotes/ of what various federal agencies do and for funding their work. This report surveys the points made so far in the debate, focusing on those that most directly influence the policy options facing the US Congress. Congressional interest focused on how to assess the rationales for conducting human genome projects, how to fund human genome projects (at what level and through which mechanisms), how to coordinate the scientific and technical programs of the several federal agencies and private interests already supporting various genome projects, and how to strike a balance regarding the impact of genome projects on international scientific cooperation and international economic competition in biotechnology. OTA prepared this report with the assistance of several hundred experts throughout the world. 342 refs., 26 figs., 11 tabs.

none,

1988-04-01T23:59:59.000Z

371

Studies on the chalcone synthase gene of two higher plants: petroselinum hortense and matthiola incana  

SciTech Connect (OSTI)

Two higher plant systems are presented which allow to study coordinated gene expression of the light-induced metabolic pathway of flavonoid biosynthesis: tissue culture cells of Petroselinum hortense (Apiaceae) and different developmental stages of various genotypes of Matthiola incana (Brassicaceae). The gene structure of the chalcone synthase is mainly studied. A cDNA clone (pLF56) of parsley has been constructed and characterized conferring the chalcone synthase gene sequence. Strong cross hybridization between the parsley cDNA and Matthiola DNA allowed to identify a HindIII fragment (6000 bp) identical in size for parsley and different Matthiola wild type lines and a mutant line.

Hemleben, V.; Frey, M.; Rall, S.; Koch, M.; Kittel, M.; Kreuzaler, F.; Ragg, H.; Fautz, E.; Hahlbrock, K.

1982-01-01T23:59:59.000Z

372

Expression and rearrangement of the ROS1 gene in human glioblastoma cells  

SciTech Connect (OSTI)

The human ROS1 gene, which possibly encodes a growth factor receptor, was found to be expressed in human tumor cell lines. In a survey of 45 different human cell lines, the authors found ROS1 to be expressed in glioblastoma-derived cell lines at high levels and not to be expressed at all, or expressed at very low levels, in the remaining cell lines. The ROS1 gene was present in normal copy numbers in all cell lines that expressed the gene. However, in one particular glioblastoma line, they detected a potentially activating mutation at the ROS1 locus.

Birchmeier, C.; Sharma, S.; Wigler, M.

1987-12-01T23:59:59.000Z

373

Mutations of the tyrosinase gene in Indo-Pakistani patients with type I (tyrosinase-deficient) oculocutaneous albinsm (OCA)  

SciTech Connect (OSTI)

Oculocutaneous albinism (OCA) is a group of autosomal recessive disorders characterized by deficient synthesis of melanin pigment. Type I (tyrosinase-deficient) OCA results from mutations of the tyrosinase gene (TYR gene) encoding tyrosinase, the enzyme that catalyzes the first two steps of melanin biosynthesis. Mutations of the TYR gene have been identified in a large number of patients, most of Caucasian ethnic origin, with various forms of type I OCA. The authors present an analysis of the TYR gene in eight Indo-Pakistani patients with type I OCA. The authors describe four novel TYR gene mutations and a fifth mutation previously observed in a Caucasian patient. 16 refs., 6 figs.

Tripathi, R.K.; Droetto, S.; Strunk, K.M.; Holmes, S.A.; Spritz, R.A. (Univ. of Wisconsin, Madison, WI (United States)); Bundey, S.; Musarella, M.A.

1993-12-01T23:59:59.000Z

374

Tyrosinase-positive oculocutaneous albinism in Southern African blacks: P gene-associated haplotypes suggest a major mutation in the 5{prime} region of the gene  

SciTech Connect (OSTI)

Tyrosinase-positive oculocutaneous albinism (ty-pos OCA) occurs with a prevalence of 1 in 3900 among Southern African (SA) blacks. The major contributors to morbidity and mortality are skin cancer and decreased visual acuity. Two distinct phenotypes occur, namely individuals with ephelides (darkly pigmented patches) and those without. There is complete concordance with regard to ephelus status among siblings. The disorder is linked to markers on chromosome 15q11.2-q12, and no obligatory cross-overs were observed with polymophic markers at the human homolog, P, of the mouse pink eyed dilute gene, p. Contrary to what has been shown for Caucasoid ty-pos OCA, this condition shows locus homogeneity among SA blacks. The P gene is an excellent candidate for ty-pos OCA and mutations in this gene will confirm its role in causing the common form of albinism in SA. Numerous P gene mutations have been described in other populations. In an attempt to detect mutations, the P gene cDNA was used to search for structural rearrangements or polymorphisms. Six polymorphisms (plR10/Scal, 912/Xbal, 912/HincII, 912/TaqI, 1412/TaqI [two systems] and 1412/HindIII) were detected with subclones of the P cDNA and haplotypes were determined in each family. None were clearly associated with an albinism-related rearrangement. However, strong linkage disequilibrium was observed with alleles at loci toward the 5{prime} region of the gene ({triangle}=0.65, 0.57 and 0.80 for the three polymorphisms detected with the 912 subclone), suggesting a major ty-pos OCA mutation in this region. Haplotype analysis provides evidence for a major mutation associated with the same haplotype in individuals with ephelides (8/12 OCA chromosomes) and those without ephelides (24:30). The presence of other ty-pos OCA associated haplotypes indicates several other less common mutations.

Ramsay, M.; Stevens, G.; Beukering, J. van [Univ. of the Witwatersrand, Johannesburg (South Africa)] [and others

1994-09-01T23:59:59.000Z

375

E-Print Network 3.0 - a-complementing xpac gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Johns Hopkins... ,000 genes. See also R.M. Henig's book The Monk in the Garden: The Lost and Found Genius of Gregor Mendel Source: Le Roy, Robert J. - Department of...

376

Sam Wang, Princeton Genes, Brain Circuits, and the Mind: From Optical Imaging to Genomics  

E-Print Network [OSTI]

Sam Wang, Princeton WANG 12-4 Genes, Brain Circuits, and the Mind: From Optical Imaging to Genomics information, my laboratory uses multiphoton optical methods to image activity in the cerebellum, a structure

Glashausser, Charles

377

Phylogenetic diversity of gram-positive bacteria and their secondary metabolite genes  

E-Print Network [OSTI]

in Oceanography by Erin Ann Gontang Committee in charge:The Dissertation of Erin Ann Gontang is approved, and it isMetabolite Genes by Erin Ann Gontang Doctor of Philosophy in

Gontang, Erin Ann

2008-01-01T23:59:59.000Z

378

E-Print Network 3.0 - adenylate cyclase gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for: adenylate cyclase gene Page: << < 1 2 3 4 5 > >> 1 Comparative and Functional Genomics Comp Funct Genom 2004; 5: 1738. Summary: Cue et al., 2000) and recently at least two...

379

Correlations Between Gene Expression and Mercury Levels in Blood of Boys With and Without Autism  

E-Print Network [OSTI]

Ingenuity Pathways Analysis (IPA) (Ingenuity Systems ,ed the pathways from the IPA library of canonical pathwaysis not possible. In this case, IPA was used to map the genes

2011-01-01T23:59:59.000Z

380

Molecular cloning and characterization of important stress and redox regulatory genes from Hydra vulgaris  

E-Print Network [OSTI]

In this research, important stress and redox regulatory genes present in Hydra vulgaris were isolated and characterized to facilitate our understanding of the evolution and mechanisms of stress response. H. vulgaris heat shock protein 70 (HvHSP70...

Dash, Bhagirathi

2007-04-25T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Molecular studies of longevity-associated genes in yeast and mammalian cells  

E-Print Network [OSTI]

Aging is a complex process affecting diverse organisms from bacteria to humans. Despite strong evolutionary arguments against the conservation of a single mechanism of aging, a variety of conserved single gene mutations ...

Liszt, Gregory (Gregory Birjandi)

2006-01-01T23:59:59.000Z

382

Quantitative analysis of non-viral gene therapy in primary liver culture systems  

E-Print Network [OSTI]

Gene therapy has the potential to cure thousands of diseases caused by genetic abnormalities, provide novel combination therapies for cancers and viral infections, and offer a new and effective platform for next generation ...

Tedford, Nathan C

2007-01-01T23:59:59.000Z

383

A Transient Transgenic RNAi Strategy for Rapid Characterization of Gene Function during Embryonic Development  

E-Print Network [OSTI]

RNA interference (RNAi) is a powerful strategy for studying the phenotypic consequences of reduced gene expression levels in model systems. To develop a method for the rapid characterization of the developmental consequences ...

Bjork, Bryan C.

384

Optimizing a protein-RNA aptamer gene regulatory system using an engineered peptide library  

E-Print Network [OSTI]

For this project, N-terminal and C-terminal peptide library fusions were designed,bconstructed, and screened in order to improve the repression achievable with a novel gene regulatory system. This system, based on the ...

Wong, Jessica Karen

2011-01-01T23:59:59.000Z

385

E-Print Network 3.0 - androgen-regulated gene expression Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sexually differentiated, androgen-regulated, larynx-specific Summary: the entire xlMyHC-LM gene. The androgen-regulated xtMyHC that predominates in the male larynx of X... -twitch...

386

Identification of sensitivity genes involved in teratogen-induced neural tube defects  

E-Print Network [OSTI]

that NTDs have a strong genetic component to their development. My project is designed to examine differential expression patterns of genes within the neural tube cells of inbred LM/Bc mouse fetuses following exposure to the known teratogenic agent...

Hayes, Blaine G

2013-02-22T23:59:59.000Z

387

Genes related to xylose fermentation and methods of using same for enhanced biofuel production  

DOE Patents [OSTI]

The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided.

Wohlbach, Dana J.; Gasch, Audrey P.

2014-08-05T23:59:59.000Z

388

Genes: Philosophical Analyses Put to the Test Karola Stotz1 and Paul Griffiths2  

E-Print Network [OSTI]

of the concept of the gene were operationalized and tested against questionnaire data obtained from working of science a case study of conceptual change and its role in science. Empirical science is a powerhouse

Stotz, Karola

389

E-Print Network 3.0 - acquired cns gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

CNS 115 Refreshments served 3:40 p.m. CNS 1st floor lobby. ALL... aphid 4:30 Eric Van Fleet (Marina Caillaud) Differential gene expression patterns in host Source: Ithaca...

390

E-Print Network 3.0 - abscisic acid gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for: abscisic acid gene Page: << < 1 2 3 4 5 > >> 1 Future Perspectives in Plant Biology Abscisic Acid Receptors Summary: ) Reduced expression of the v-SNAREs AtVAMP71...

391

E-Print Network 3.0 - age-dependent gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

search results for: age-dependent gene expression Page: << < 1 2 3 4 5 > >> 1 Current Biology, Vol. 12, 712723, April 30, 2002, 2002 Elsevier Science Ltd. All rights reserved. PII...

392

Hairpin RNAs and Retrotransposon LTRs Effect RNAi and Chromatin-Based Gene Silencing  

E-Print Network [OSTI]

The expression of short hairpin RNAs in several organisms silences gene expression by targeted mRNA degradation. This RNA interference (RNAi) pathway can also affect the genome, as DNA methylation arises at loci homologous ...

Schramke, Vera; Allshire, Robin C

2003-01-01T23:59:59.000Z

393

Discovery of Genes and Genomes through Deep Metagenomic Sequencing of Cow Rumen (2010 JGI User Meeting)  

ScienceCinema (OSTI)

Director Eddy Rubin on "Discovery of Genes and Genomes through Deep Metagenomic Sequencing of Cow Rumen" on March 25, 2010 at the 5th Annual DOE JGI User Meeting

Rubin, Eddy

2011-04-25T23:59:59.000Z

394

Modeling the Fitness Consequences of a Cyanophage-Encoded Photosynthesis Gene  

E-Print Network [OSTI]

Background: Phages infecting marine picocyanobacteria often carry a psbA gene, which encodes a homolog to the photosynthetic reaction center protein, D1. Host encoded D1 decays during phage infection in the light. Phage ...

Chisholm, Sallie (Penny)

395

Genomic Insights into Sexual Selection and the Evolution of Reproductive Genes in Teleost Fishes  

E-Print Network [OSTI]

that genes associated with reproductive biology evolve especially rapidly planted this notion, but many details about the genomics of sex remain elusive. Numerous studies have characterized rapid sequence and expression divergence of sex-related molecules...

Small, Clayton

2012-10-19T23:59:59.000Z

396

Variability in the Stability and Productivity of Transfected Genes in Chinese Hamster Ovary (CHO) cells  

E-Print Network [OSTI]

In the field of biologics production, productivity and stability of the transfected gene of interest are two very important attributes that dictate if a production process is viable. To further understand and improve these ...

Ng, Say Kong

397

E-Print Network 3.0 - activity mia-like gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

: Castillo-Davis, C. I. and D. L. Hartl. 2003. GeneMerge-- post-genomic analysis, data-mining and hypothesis... testing. Bioinformatics 19(7):891-892 http:www.oeb.harvard.edu...

398

E-Print Network 3.0 - antagonist gene il-1rn Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Information 1 Non-centrality Parameters Summary: Position Gene Control Fam Statistic df P-value IL1RN dad&mom 121 THP 5.17 1 0.023 439154 115064289 IL1... 115068445...

399

Nucleotide diversity and neutrality testing in genes involved in adaptation in Douglas-fir  

E-Print Network [OSTI]

Nucleotide diversity and neutrality testing in genes involved in adaptation in Douglas-fir B. Pande-Oregon region, and 684 SNPs were identified in total. We report the estimation of nucleotide diversity and tests

400

HUMAN GENE THERAPY 18:871880 (October 2007) Mary Ann Liebert, Inc.  

E-Print Network [OSTI]

HUMAN GENE THERAPY 18:871­880 (October 2007) © Mary Ann Liebert, Inc. DOI: 10.1089/hum.2007 of funda- mental questions in retinal biology. 871 INTRODUCTION RNA INTERFERENCE (RNAi) is an approach

Kay, Mark A.

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

HUMAN GENE THERAPY 14:871881 (June 10, 2003) Mary Ann Liebert, Inc.  

E-Print Network [OSTI]

HUMAN GENE THERAPY 14:871­881 (June 10, 2003) © Mary Ann Liebert, Inc. Pathways of Removal of Free ends. These studies shed new light on the molecular mechanisms of rAAV vector transduction in vivo. 871

Kay, Mark A.

402

Identifying genes that are required for the maintenance of pancreatic ductal adenocarcinoma  

E-Print Network [OSTI]

We searched for genes that are potentially important for the maintenance of Pancreatic Ductal Adenocarcinoma (PDAC). PDAC is the 4th leading cause for cancer-related deaths and exhibits a 5-year survival rate of less than ...

Jenq, Harry

2012-01-01T23:59:59.000Z

403

E-Print Network 3.0 - adenovirus-mediated gene transfer Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

67 Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki Summary: , Stricker H, Pegg J et al. Phase I study of replica- tion-competent adenovirus-mediated...

404

E-Print Network 3.0 - affects odontoblast gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: mice expression of the other non-targeted Runx genes is not affected (Stricker et al., 2002; Yamashiro... in these epithelia is regulated by TGF-b is an interesting...

405

E-Print Network 3.0 - adenovirus-mediated gene therapy Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

47 Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki Summary: , Stricker H, Pegg J et al. Phase I study of replica- tion-competent adenovirus-mediated...

406

E-Print Network 3.0 - adenovirus-mediated gene delivery Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

58 Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki Summary: , Stricker H, Pegg J et al. Phase I study of replica- tion-competent adenovirus-mediated...

407

Exploring the specificity and mechanisms of siRNA-mediated gene silencing in mammalian cells  

E-Print Network [OSTI]

Complementary short interfering RNAs (siRNAs) are routinely used to knockdown gene expression. siRNAs bind to their target sequence and guide transcript cleavage and subsequent degradation. This type of silencing is ...

Alemn, Lourdes Maria

2008-01-01T23:59:59.000Z

408

A fast, robust and tunable synthetic gene oscillator Jesse Stricker1  

E-Print Network [OSTI]

LETTERS A fast, robust and tunable synthetic gene oscillator Jesse Stricker1 *, Scott Cookson1 *, Matthew R. Bennett1,2 *, William H. Mather1 , Lev S. Tsimring2 & Jeff Hasty1,2 One defining goal

Hasty, Jeff

409

Effects of Alcohol on the Regulation of Imprinted Genes in Mouse Stem Cells  

E-Print Network [OSTI]

ABSTRACT Effects of Alcohol on the Regulation of Imprinted Genes in Mouse Stem Cells. (December 2013) Alyssa Crocker Department of Animal Science Texas A&M University Research Advisor: Dr. Michael Golding Department of Veterinary Physiology...

Crocker, Alyssa

2013-02-04T23:59:59.000Z

410

E-Print Network 3.0 - aromatase gene defines Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

gene defines Page: << < 1 2 3 4 5 > >> 1 ORIGINAL ARTICLE Aromatase mRNA in the Brain of Adult Green Anole Lizards: Effects of Summary: to previous work using Nissl-stained...

411

E-Print Network 3.0 - aromatase gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

gene expression Page: << < 1 2 3 4 5 > >> 1 ORIGINAL ARTICLE Aromatase mRNA in the Brain of Adult Green Anole Lizards: Effects of Summary: of testosterone to oestradiol (E2)...

412

Examination of dioxin and its alteration of gene expression via DNA Microarray Analysis  

E-Print Network [OSTI]

), and ADD/ADHD. Little evidence has been available to demonstrate how dioxin specifically alters gene expression, both in developing embryos and adults. Recently, Texas A&M University has acquired several DNA Microarray Systems, which are revolutionizing...

Wright, Justin Charles

2013-02-22T23:59:59.000Z

413

Mechanisms of transcriptional activation of estrogen responsive genes in breast cancer cells  

E-Print Network [OSTI]

Estrogen receptor (ER) acts as a ligand-activated transcription factor that regulates the expression of genes. The genomic mechanisms of ER action include ligand-induced dimerization of ER which binds estrogen responsive elements (EREs...

Chen, Chien-Cheng

2009-06-02T23:59:59.000Z

414

Scientific Methods Workshop: Ecological and Agronomic Consequences of Gene Flow from  

E-Print Network [OSTI]

Scientific Methods Workshop: Ecological and Agronomic Consequences of Gene Flow from Transgenic Prevention Division, U.S. EPA" Robert Zemetra, University of Idaho 178 "The evolution of a biological risk

Snow, Allison A.

415

Gene Expression and Association Analyses of Stress Responses in Loblolly Pine (Pinus taeda L.)  

E-Print Network [OSTI]

The molecular mechanisms underlying disease-resistance and drought-resistance in forest trees are not well understood. Linking variation in gene expression with genetic polymorphisms and with variations in disease- and drought-resistance phenotypes...

Seeve, Candace Marie

2012-02-14T23:59:59.000Z

416

Moral obligation and the human germ-line gene therapy debate  

E-Print Network [OSTI]

genetic engineering, there are few arguments made for a positive moral obligation to genetic intervention. This is especially so with respect to human germ-line gene therapy. Burke. K. Zimmerman makes one of the few arguments that society...

Clark, Alan B

1998-01-01T23:59:59.000Z

417

The compact Selaginella genome identifies changes in gene content associated with the evolution of vascular plants  

SciTech Connect (OSTI)

We report the genome sequence of the nonseed vascular plant, Selaginella moellendorffii, and by comparative genomics identify genes that likely played important roles in the early evolution of vascular plants and their subsequent evolution

Grigoriev, Igor V.; Banks, Jo Ann; Nishiyama, Tomoaki; Hasebe, Mitsuyasu; Bowman, John L.; Gribskov, Michael; dePamphilis, Claude; Albert, Victor A.; Aono, Naoki; Aoyama, Tsuyoshi; Ambrose, Barbara A.; Ashton, Neil W.; Axtell, Michael J.; Barker, Elizabeth; Barker, Michael S.; Bennetzen, Jeffrey L.; Bonawitz, Nicholas D.; Chapple, Clint; Cheng, Chaoyang; Correa, Luiz Gustavo Guedes; Dacre, Michael; DeBarry, Jeremy; Dreyer, Ingo; Elias, Marek; Engstrom, Eric M.; Estelle, Mark; Feng, Liang; Finet, Cedric; Floyd, Sandra K.; Frommer, Wolf B.; Fujita, Tomomichi; Gramzow, Lydia; Gutensohn, Michael; Harholt, Jesper; Hattori, Mitsuru; Heyl, Alexander; Hirai, Tadayoshi; Hiwatashi, Yuji; Ishikawa, Masaki; Iwata, Mineko; Karol, Kenneth G.; Koehler, Barbara; Kolukisaoglu, Uener; Kubo, Minoru; Kurata, Tetsuya; Lalonde, Sylvie; Li, Kejie; Li, Ying; Litt, Amy; Lyons, Eric; Manning, Gerard; Maruyama, Takeshi; Michael, Todd P.; Mikami, Koji; Miyazaki, Saori; Morinaga, Shin-ichi; Murata, Takashi; Mueller-Roeber, Bernd; Nelson, David R.; Obara, Mari; Oguri, Yasuko; Olmstead, Richard G.; Onodera, Naoko; Petersen, Bent Larsen; Pils, Birgit; Prigge, Michael; Rensing, Stefan A.; Riano-Pachon, Diego Mauricio; Roberts, Alison W.; Sato, Yoshikatsu; Scheller, Henrik Vibe; Schulz, Burkhard; Schulz, Christian; Shakirov, Eugene V.; Shibagaki, Nakako; Shinohara, Naoki; Shippen, Dorothy E.; Sorensen, Iben; Sotooka, Ryo; Sugimoto, Nagisa; Sugita, Mamoru; Sumikawa, Naomi; Tanurdzic, Milos; Theilsen, Gunter; Ulvskov, Peter; Wakazuki, Sachiko; Weng, Jing-Ke; Willats, William W.G.T.; Wipf, Daniel; Wolf, Paul G.; Yang, Lixing; Zimmer, Andreas D.; Zhu, Qihui; Mitros, Therese; Hellsten, Uffe; Loque, Dominique; Otillar, Robert; Salamov, Asaf; Schmutz, Jeremy; Shapiro, Harris; Lindquist, Erika; Lucas, Susan; Rokhsar, Daniel

2011-04-28T23:59:59.000Z

418

Palindromes on the human X chromosome : testis-biased transcription, gene conversion and evolution  

E-Print Network [OSTI]

Recent genomic studies of the Y chromosome revealed massive, testis-specific palindromes that span 30% of the chromosome and are subject to gene conversion. We conducted studies to determine whether similar palindromes ...

Saionz, Jennifer R., 1976-

2005-01-01T23:59:59.000Z

419

Irradiated Esophageal Cells are Protected from Radiation-Induced Recombination by MnSOD Gene Therapy  

E-Print Network [OSTI]

Radiation-induced DNA damage is a precursor to mutagenesis and cytotoxicity. During radiotherapy, exposure of healthy tissues can lead to severe side effects. We explored the potential of mitochondrial SOD (MnSOD) gene ...

Niu, Yunyun

420

Synthesis and chemical modification of degradable polymers to enhance gene delivery  

E-Print Network [OSTI]

Poly([beta]-amino ester)s are a class of cationic, degradable polymers that have shown significant promise as gene delivery agents, more effective than the state-of-the-art, commercially available non-viral systems. The ...

Zugates, Gregory Thomas

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Mysteries of the Deep: What happens inside of MPI on Blue Gene...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mysteries of the Deep: What happens inside of MPI on Blue GeneQ and why it matters Jeff Hammond Leadership Computing Facility Argonne National Laboratory March 5, 2013 Jeff...

422

E-Print Network 3.0 - anti-cancer target gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: anti-cancer target gene Page: << < 1 2 3 4 5 > >> 1 THE BETTER WORLD REPORT PART TWO Biotechnology...

423

Heterogeneity of tumor-induced gene expression changes in the human metabolic network  

E-Print Network [OSTI]

Reprogramming of cellular metabolism is an emerging hallmark of neoplastic transformation. However, it is not known how the expression of metabolic genes in tumors differs from that in normal tissues, or whether different ...

Hu, Jie

424

Kiss1 Gene Expression and the Effects of Kisspeptin During Pubertal Development in the Ewe Lamb  

E-Print Network [OSTI]

puberty. In Experiment 1, ovariectomized ewe lambs bearing subcutaneous estradiol implants were used to investigate Kiss1 gene expression in the preoptic area (POA) and hypothalamus during pubertal maturation of the reproductive neuroendocrine system...

Redmond, Jeremy Scott

2012-02-14T23:59:59.000Z

425

Fitting It All Together: How Courtship- and Mating-Responsive Genes Affect Drosophila melanogaster Male Behavior  

E-Print Network [OSTI]

by utilizing microarray technology to assess courtship- or mating-induced gene expression changes in Drosophila male whole bodies or heads. Mutations in candidate loci were tested for effects on reproductive behaviors and present the first data showing...

Ellis, Lisa Lynn

2011-10-21T23:59:59.000Z

426

Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and nonparallel physiological  

E-Print Network [OSTI]

of parallel and nonparallel physiological divergence M. L. EVANS* & L. BERNATCHEZ Institut de Biologie Inte: Coregonus; gene transcription; metabolism; oxidative phosphorylation; phenotypic divergence; physiology mitochondrial and nuclear genome-encoded oxidative phosphorylation (OXPHOS) complexes, the primary physiological

Bernatchez, Louis

427

Whole-Exome Sequencing and Homozygosity Analysis Implicate Depolarization-Regulated Neuronal Genes in Autism  

E-Print Network [OSTI]

Although autism has a clear genetic component, the high genetic heterogeneity of the disorder has been a challenge for the identification of causative genes. We used homozygosity analysis to identify probands from ...

Schubert, Christian R.

428

Novel enabling technologies of gene isolation and plant transformation for improved crop protection  

SciTech Connect (OSTI)

Meeting the needs of agricultural producers requires the continued development of improved transgenic crop protection products. The completed project focused on developing novel enabling technologies of gene discovery and plant transformation to facilitate the generation of such products.

Torok, Tamas

2013-02-04T23:59:59.000Z

429

p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair  

E-Print Network [OSTI]

The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that ...

Lin, Yu-Li

430

Characterization in cochlea of KCTD12/PFET1, an intronless gene with predominant fetal expression  

E-Print Network [OSTI]

The prevalence of severe to profound bilateral congenital hearing loss is estimated at 1 in 1000 births, at least half of which can be attributed to a genetic cause. To date, mutations in at least 67 genes have been ...

Kuo, Sharon Fan

2006-01-01T23:59:59.000Z

431

E-Print Network 3.0 - anaerobic gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Medicine 15 Proc. Natl. Acad. Sci. USA Vol. 93, pp. 3575-3580, April 1996 Summary: and environmental regulation of nitro- genase gene expression and enzyme activity would expand...

432

Biomedical data retrieval utilizing textual data in a gene expression database by Richard Lu, MD.  

E-Print Network [OSTI]

Background: The commoditization of high-throughput gene expression sequencing and microarrays has led to a proliferation in both the amount of genomic and clinical data that is available. Descriptive textual information ...

Lu, Richard, M.D

2010-01-01T23:59:59.000Z

433

A role for the Spemann organizer gene, Goosecoid, in tumor metastasis  

E-Print Network [OSTI]

The process of invasion and metastasis during tumor progression is often reminiscent of cell migration events occurring during embryonic development. I hypothesized that genes controlling cellular changes in the Spemann ...

Hartwell, Kimberly A. (Kimberly Ann)

2007-01-01T23:59:59.000Z

434

BMP7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis In Vivo  

E-Print Network [OSTI]

This study examined the effects of BMP7 gene transfer on corneal wound healing and fibrosis inhibition in vivo using a rabbit model. Corneal haze in rabbits was produced with the excimer laser performing -9 diopters ...

Tandon, Ashish

435

Gene silencing in cancer cells using siRNA : genetic and functional studies  

E-Print Network [OSTI]

modulators??????. 73 VI Different phenotypes in ERs knockout mice??????????. 78 VII Regulatory factors of VEGF gene expression?????????.. 106 VIII Single chemotherapy used to treat pancreatic cancer?????? 109 IX Combination... analysis a possibility (89). For example targeting of essential and non-essential genes resulted in cellular phenotypes that were identical to phenotypes previously observed in cells derived from transgenic knockout mice (89), illustrating the value...

Abdel Rahim, Ma'en Ahmad

2004-09-30T23:59:59.000Z

436

Physiological Ageing as it is Related to Gene Function in the Lone Star Tick, Amblyomma americanum  

E-Print Network [OSTI]

............................ 15 Figure 4 Electrophoresis gel results for the expression of the 16S gene in Amblyomma americanum subdivided by the mortality percentile to the right of the result, the sample number over the top of the result, and the group... as assessed by Image J software displaying the expression of Amblyomma americaum gene 16S for the female control (FC), male control (MC), female experimental (FE), and male experimental (ME) groups from Day 0 to Day 77...

Catena, Amanda M.

2010-07-14T23:59:59.000Z

437

Genetic evaluation of the ovine and bovine prion protein genes (PRNP)  

E-Print Network [OSTI]

GENETIC EVALUATION OF THE OVINE AND BOVINE PRION PROTEIN GENES (PRNP) A Dissertation by CHRISTOPHER MARK SEABURY Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of DOCTOR OF PHILOSOPHY December 2004 Major Subject: Genetics GENETIC EVALUATION OF THE OVINE AND BOVINE PRION PROTEIN GENES (PRNP) A Dissertation by CHRISTOPHER MARK SEABURY Submitted to Texas A&M...

Seabury, Christopher Mark

2006-04-12T23:59:59.000Z

438

The Effects of Alcohol on the Regulation of Imprinted Genes in Mouse Embryonic Stem Cells  

E-Print Network [OSTI]

THE EFFECTS OF ALCOHOL ON THE REGULATION OF IMPRINTED GENES IN MOUSE EMBRYONIC STEM CELLS An Undergraduate Research Scholars Thesis by ELIZABETH MARY VILLANUEVA Submitted to Honors and Undergraduate Research Texas A... ................................................................................................... 25 2 ABSTRACT The Effects of Alcohol on the Regulation of Imprinted Genes in Mouse Embryonic Stem Cells. (May 2013) Elizabeth Mary Villanueva Department of Interdisciplinary Studies Texas A&M University Research Advisor: Dr...

Villanueva, Elizabeth Mary

2013-02-04T23:59:59.000Z

439

Knowledge-based analysis of microarray gene expression data by using support vector machines  

SciTech Connect (OSTI)

The authors introduce a method of functionally classifying genes by using gene expression data from DNA microarray hybridization experiments. The method is based on the theory of support vector machines (SVMs). SVMs are considered a supervised computer learning method because they exploit prior knowledge of gene function to identify unknown genes of similar function from expression data. SVMs avoid several problems associated with unsupervised clustering methods, such as hierarchical clustering and self-organizing maps. SVMs have many mathematical features that make them attractive for gene expression analysis, including their flexibility in choosing a similarity function, sparseness of solution when dealing with large data sets, the ability to handle large feature spaces, and the ability to identify outliers. They test several SVMs that use different similarity metrics, as well as some other supervised learning methods, and find that the SVMs best identify sets of genes with a common function using expression data. Finally, they use SVMs to predict functional roles for uncharacterized yeast ORFs based on their expression data.

William Grundy; Manuel Ares, Jr.; David Haussler

2001-06-18T23:59:59.000Z

440

Annu. Rev. Earth Planet. Sci. 2005. 33:53170 doi: 10.1146/annurev.earth.33.092203.122614  

E-Print Network [OSTI]

Annu. Rev. Earth Planet. Sci. 2005. 33:531­70 doi: 10.1146/annurev.earth.33.092203.122614 Copyright on February 1, 2005 THE Hf-W ISOTOPIC SYSTEM AND THE ORIGIN OF THE EARTH AND MOON Stein B. Jacobsen Department of Earth and Planetary Sciences, Harvard University, Cambridge, Massachusetts 02138; email: jacobsen

Jellinek, Mark

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

LM Glasfiber er verdens strste pro-ducent af vinger til vindmller.  

E-Print Network [OSTI]

LM Glasfiber er verdens største pro- ducent af vinger til vindmøller. Udvikling og afprøvning af mekaniske test", forklarer civilinge- niør Torben Jacobsen fra LM Glasfiber. LM Glasfiber i Lunderskov er internationale vindmølle-fabrikanter. Torben Jacobsen kom til LM Glasfiber fra Risø, hvor han var tilknyttet

442

Progesterone and interferon tau regulated genes in the endometrium of the ovine uterus and expression of interferon stimulated genes in the corpus luteum during early pregnancy in sheep  

E-Print Network [OSTI]

genes identified by previous custom ovine cDNA microarray analyses. ACTA2, COL3A1, POSTN, SPARC, S100A2, STAT5A and TAGLN were examined. POSTN was upregulated by P4 and S100A2 was downregulated by IFNT. Moreover, functional studies showed that POSTN...

Ahn, Hyo Won

2008-10-10T23:59:59.000Z

443

Gene expression profiling in Ishikawa cells: A fingerprint for estrogen active compounds  

SciTech Connect (OSTI)

Several anthropogenous and naturally occurring substances, referred to as estrogen active compounds (EACs), are able to interfere with hormone and in particular estrogen receptor signaling. EACs can either cause adverse health effects in humans and wildlife populations or have beneficial effects on estrogen-dependent diseases. The aim of this study was to examine global gene expression profiles in estrogen receptor (ER)-proficient Ishikawa plus and ER-deficient Ishikawa minus endometrial cancer cells treated with selected well-known EACs (Diethylstilbestrol, Genistein, Zearalenone, Resveratrol, Bisphenol A and o,p'-DDT). We also investigated the effect of the pure antiestrogen ICI 182,780 (ICI) on the expression patterns caused by these compounds. Transcript levels were quantified 24 h after compound treatment using Illumina BeadChip Arrays. We identified 87 genes with similar expression changes in response to all EAC treatments in Ishikawa plus. ICI lowered the magnitude or reversed the expression of these genes, indicating ER dependent regulation. Apart from estrogenic gene regulation, Bisphenol A, o,p'-DDT, Zearalenone, Genistein and Resveratrol displayed similarities to ICI in their expression patterns, suggesting mixed estrogenic/antiestrogenic properties. In particular, the predominant antiestrogenic expression response of Resveratrol could be clearly distinguished from the other test compounds, indicating a distinct mechanism of action. Divergent gene expression patterns of the phytoestrogens, as well as weaker estrogenic gene expression regulation determined for the anthropogenous chemicals Bisphenol A and o,p'-DDT, warrants a careful assessment of potential detrimental and/or beneficial effects of EACs. The characteristic expression fingerprints and the identified subset of putative marker genes can be used for screening chemicals with an unknown mode of action and for predicting their potential to exert endocrine disrupting effects.

Boehme, Kathleen; Simon, Stephanie [Merck KGaA, Merck Serono, NCD/Toxicology, Early and Explanatory Toxicology, 64271 Darmstadt (Germany); Mueller, Stefan O. [Merck KGaA, Merck Serono, NCD/Toxicology, Early and Explanatory Toxicology, 64271 Darmstadt (Germany)], E-mail: stefan.o.mueller@merck.de

2009-04-01T23:59:59.000Z

444

DNA rearrangement in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene  

SciTech Connect (OSTI)

In most human lymphomas, the chromosome translocation t(14;18) occurs within two breakpoint clustering regions on chromosome 18, the major one at the 3' untranslated region of the bcl-2 gene and the minor one at 3' of the gene. Analysis of a panel of follicular lymphoma DNAs using probes for the first exon of the bcl-2 gene indicates that DNA rearrangements may also occur 5' to the involved bcl-2 gene. In this case the IgH locus and the bcl-2 gene are found in an order suggesting that an inversion also occurred during the translocation process. The coding region of the bcl-2 gene, however, are left intact in all cases of follicular lymphoma studied to date.

Tsujimoto, Y.; Bashir, M.M.; Givol, I.; Cossman, J.; Jaffe, E.; Croce, C.M.

1987-03-01T23:59:59.000Z

445

Molecular cloning and localization of the human GAX gene to 7p21  

SciTech Connect (OSTI)

The GAX homeobox gene is expressed in the cardiovascular tissues of the adult rat, including heart, lung, kidney, and blood vessels. In the vasculature it is specifically expressed in quiescent smooth muscle cells, but its expression is rapidly down-regulated when these cells are stimulated to proliferate with mitogens. Since vascular smooth muscle cell proliferation is important in the pathology of blood vessel disorders, the human GAX gene was isolated and characterized. The human GAX cDNA was obtained by an anchored-PCR approach using cDNA templates from cardiovascular tissues and amplification primers designed from sequence information of the rat GAK cDNA and the homeodomain-containing exon of the human GAX gene. The human and rat GAX gene coding sequences are 98% conserved at the amino acid level and 83% conserved at the nucleotide level. Similar to rat, the human homolog contains a CAX trinucleotide repeat N-terminal to the homeodomain that encodes for a stretch of 17 consecutive histidine or glutamine residues. The human GAX locus was mapped by fluorescence in situ hybridization to the short arm of chromosome 7 at band p21. The human cDNA sequence will be useful for analyses of GAX gene expression in cardiovascular diseases. 30 refs., 3 figs., 1 tab.

LePage, D.F. [Case Western Reserve Univ., Cleveland, OH (United States)] [Case Western Reserve Univ., Cleveland, OH (United States); Altomare, D.A.; Testa, J.R. [Fox Chase Cancer Center, Philadelphia, PA (United States)] [and others] [Fox Chase Cancer Center, Philadelphia, PA (United States); and others

1994-12-01T23:59:59.000Z

446

Identification of Novel Virulence Genes of Salmonella enterica Using an Array Based Analysis of Cistrons Under Selection  

E-Print Network [OSTI]

the identification of genes required for Salmonella survival in many environments. Identification of Salmonella genes necessary for growth in different niches has made rapid progress in recent years, as the molecular biologic tools for their identification become... more sophisticated and are applied to study this organism in an increasing number of environments. In the following chapter I detail the identification of Salmonella genes required in niches that have been studied to date, and describe advances...

Reynolds, Mollie Megan

2011-08-08T23:59:59.000Z

447

Identification of genes in anonymous DNA sequences. Final report: Report period, 15 April 1993--15 April 1994  

SciTech Connect (OSTI)

This Report concludes the DOE Human Genome Program project, ``Identification of Genes in Anonymous DNA Sequence.`` The central goals of this project have been (1) understanding the problem of identifying genes in anonymous sequences, and (2) development of tools, primarily the automated identification system gm, for identifying genes. The activities supported under the previous award are summarized here to provide a single complete report on the activities supported as part of the project from its inception to its completion.

Fields, C.A.

1994-09-01T23:59:59.000Z

448

Diversity and depth-specific distribution of SAR11 cluster rRNA genes from marine planktonic bacteria  

SciTech Connect (OSTI)

Small-subunit (SSU) ribosomal DNA (rDNA) gene clusters are phylogenetically related sets of SSU rRNA genes, commonly encountered in genes amplified from natural populations. Genetic variability in gene clusters could result form artifacts (polymerase error or PCR chimera formation), microevolution (variation among rrn copies within strains), or macroevolution (genetic divergence correlated with long-term evolutionary divergence). To better understand gene clusters, this study assessed genetic diversity and distribution of a single environmental SSU rDNA gene cluster, the SAR11 cluster. SAR11 cluster genes, from an uncultured group of the {alpha} subclass of the class Proteobacteria, have been recovered from coastal and midoceanic waters of the North Atlantic and Pacific. We cloned and bidirectionally sequenced 23 new SAR11 cluster 16S rRNA genes, from 80 and 250 m im the Sargasso Sea and from surface coastal waters of the Atlantic and Pacific, and analyzed them with previously published sequences. Two SAR11 genes were obviously PCR chimeras, but the biological (nonchimeric) origins of most subgroups within the cluster were confirmed by independent recovery from separate gene libraries. Using group-specific oligonucleotide probes, we analyzed depth profiles of nucleic acids, targeting both amplified rDNAs and bulk RNAs. Two subgroups within the SAR11 cluster showed different highly depth-specific distributions. We conclude that some of the genetic diversity within the SAR11 gene cluster represents macroevolutionary divergence correlated with niche specialization. Furthermore, we demonstrate the utility for marine microbial ecology of oligonucleotide probes based on gene sequences amplified from natural populations and show that a detailed knowledge of sequence variability may be needed to effectively design these probes. 48 refs., 7 figs., 3 tabs.

Field, K.G.; Gordon, D.; Wright, T. [Oregon State Univ., Corvallis, OR (United States)] [and others

1997-01-01T23:59:59.000Z

449

Production of glycoprotein-deleted rabies viruses for monosynaptic tracing and high-level gene expression in neurons  

E-Print Network [OSTI]

Recombinant rabies viruses rendered replication-deficient by the deletion of their envelope glycoprotein gene are useful tools for neuroscientists, permitting (1) extraordinarily high transgene expression levels within ...

Wickersham, Ian R.

450

Improving Functional Analysis of Genes Relevant to Environmental Restoration via an Analysis of the Genome of Geobacter Sulfurreducens  

SciTech Connect (OSTI)

This project elucidated the function of a number of genes involved in electron transport and other important functions in Geobacter sulfurreducens.

Lovely, D. R.

2005-06-27T23:59:59.000Z

451

Linking Advanced Visualization and MATLAB for the Analysis of 3D Gene Expression Data  

SciTech Connect (OSTI)

Three-dimensional gene expression PointCloud data generated by the Berkeley Drosophila Transcription Network Project (BDTNP) provides quantitative information about the spatial and temporal expression of genes in early Drosophila embryos at cellular resolution. The BDTNP team visualizes and analyzes Point-Cloud data using the software application PointCloudXplore (PCX). To maximize the impact of novel, complex data sets, such as PointClouds, the data needs to be accessible to biologists and comprehensible to developers of analysis functions. We address this challenge by linking PCX and Matlab via a dedicated interface, thereby providing biologists seamless access to advanced data analysis functions and giving bioinformatics researchers the opportunity to integrate their analysis directly into the visualization application. To demonstrate the usefulness of this approach, we computationally model parts of the expression pattern of the gene even skipped using a genetic algorithm implemented in Matlab and integrated into PCX via our Matlab interface.

Ruebel, Oliver; Keranen, Soile V.E.; Biggin, Mark; Knowles, David W.; Weber, Gunther H.; Hagen, Hans; Hamann, Bernd; Bethel, E. Wes

2011-03-30T23:59:59.000Z

452

Cloning and expression of the gene for bacteriophage T7 RNA polymerase  

DOE Patents [OSTI]

This application describes a means to clone a functional gene for bacteriophage T7 RNA polymerase. Active T7 RNA polymerase is produced from the cloned gene, and a plasmid has been constructed that can produce the active enzyme in large amounts. T7 RNA polymerase transcribes DNA very efficiently and is highly selective for a relatively long promoter sequence. This enzyme is useful for synthesizing large amounts of RNA in vivo or in vitro, and is capable of producing a single RNA selectively from a complex mixture of DNAs. The procedure used to obtain a clone of the R7 RNA polymerase gene can be applied to other T7-like phages to obtain clones that produce RNA polymerases having different promoter specificities, different bacterial hosts, or other desirable properties. T7 RNA polymerase is also used in a system for selective, high-level synthesis of RNAs and proteins in suitable host cells. 10 figs.

Studier, F.W.; Davanloo, P.; Rosenberg, A.H.; Moffatt, B.A.; Dunn, J.J.

1999-02-09T23:59:59.000Z

453

Resveratrol inhibits LXR?-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction  

SciTech Connect (OSTI)

Liver X receptor-? (LXR?), a member of the nuclear receptor superfamily of ligand-activated transcription factors, regulates de novo fatty acid synthesis that leads to stimulate hepatic steatosis. Although, resveratrol has beneficial effects on metabolic disease, it is not known whether resveratrol affects LXR?-dependent lipogenic gene expression. This study investigated the effect of resveratrol in LXR?-mediated lipogenesis and the underlying molecular mechanism. Resveratrol inhibited the ability of LXR? to activate sterol regulatory element binding protein-1c (SREBP-1c) and thereby inhibited target gene expression in hepatocytes. Moreover, resveratrol decreased LXR?RXR? DNA binding activity and LXRE-luciferase transactivation. Resveratrol is known to activate Sirtuin 1 (Sirt1) and AMP-activated protein kinase (AMPK), although its precise mechanism of action remains controversial. We found that the ability of resveratrol to repress T0901317-induced SREBP-1c expression was not dependent on AMPK and Sirt1. It is well established that hepatic steatosis is associated with antioxidant and redox signaling. Our data showing that expression of Sestrin2 (Sesn2), which is a novel antioxidant gene, was significantly down-regulated in the livers of high-fat diet-fed mice. Moreover, resveratrol up-regulated Sesn2 expression, but not Sesn1 and Sesn3. Sesn2 overexpression repressed LXR?-activated SREBP-1c expression and LXRE-luciferase activity. Finally, Sesn2 knockdown using siRNA abolished the effect of resveratrol in LXR?-induced FAS luciferase gene transactivation. We conclude that resveratrol affects Sesn2 gene induction and contributes to the inhibition of LXR?-mediated hepatic lipogenesis. - Highlights: We investigated the effect of resveratrol in LXR?-mediated lipogenesis. Resveratrol attenuated the ability of the LXR?-mediated lipogenic gene expression. Resveratrols effects on T090-induced lipogenesis is not dependent on Sirt1 or AMPK. Sestrin2 induction by resveratrol contributes to the inhibition of the LXR? activity.

Jin, So Hee; Yang, Ji Hye; Shin, Bo Yeon; Seo, Kyuhwa; Shin, Sang Mi [College of Pharmacy, Chosun University, Gwangju 501-759 (Korea, Republic of); Cho, Il Je, E-mail: skek023@dhu.ac.kr [MRC-GHF, College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbukdo 712-715 (Korea, Republic of); Ki, Sung Hwan, E-mail: shki@chosun.ac.kr [College of Pharmacy, Chosun University, Gwangju 501-759 (Korea, Republic of)

2013-08-15T23:59:59.000Z

454

Genetic polymorphism in three glutathione s-transferase genes and breast cancer risk  

SciTech Connect (OSTI)

The role of the glutathione S-transferase (GST) enzyme family is to detoxify environmental toxins and carcinogens and to protect organisms from their adverse effects, including cancer. The genes GSTM1, GSTP1, and GSTT1 code for three GSTs involved in the detoxification of carcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and benzene. In humans, GSTM1 is deleted in about 50% of the population, GSTT1 is absent in about 20%, whereas the GSTP1 gene has a single base polymorphism resulting in an enzyme with reduced activity. Epidemiological studies indicate that GST polymorphisms increase the level of carcinogen-induced DNA damage and several studies have found a correlation of polymorphisms in one of the GST genes and an increased risk for certain cancers. We examined the role of polymorphisms in genes coding for these three GST enzymes in breast cancer. A breast tissue collection consisting of specimens of breast cancer patients and non-cancer controls was analyzed by polymerase chain reaction (PCR) for the presence or absence of the GSTM1 and GSTT1 genes and for GSTP1 single base polymorphism by PCR/RFLP. We found that GSTM1 and GSTT1 deletions occurred more frequently in cases than in controls, and GSTP1 polymorphism was more frequent in controls. The effective detoxifier (putative low-risk) genotype (defined as presence of both GSTM1 and GSTT1 genes and GSTP1 wild type) was less frequent in cases than controls (16% vs. 23%, respectively). The poor detoxifier (putative high-risk) genotype was more frequent in cases than controls. However, the sample size of this study was too small to provide conclusive results.

Woldegiorgis, S.; Ahmed, R.C.; Zhen, Y.; Erdmann, C.A.; Russell, M.L.; Goth-Goldstein, R.

2002-04-01T23:59:59.000Z

455

CHARACTERIZING THE ROLE OF THE NELL1 GENE IN CARDIOVASCULAR DEVELOPMENT  

SciTech Connect (OSTI)

Nell1{sup 6R} is a chemically-induced point mutation in a novel cell-signaling gene, Nell1, which results in truncation of the protein and degradation of the Nell16R transcript. Earlier studies revealed that loss of Nell1 function reduces expression of numerous extracellular matrix (ECM) proteins required for differentiation of bone and cartilage precursor cells, thereby causing severe skull and spinal defects. Since skeletal and cardiovascular development are closely linked biological processes, this research focused on: a) examining Nell16R mutant mice for cardiovascular defects, b) determining Nell1 expression in fetal and adult hearts, and c) establishing how ECM genes affected by Nell1 infl uence heart development. Structural heart defects in Nell16R mutant fetuses were analyzed by heart length and width measurements and standard histological methods (haematoxylin and eosin staining). Nell1 expression was assayed in fetal and adult hearts using reverse transcription polymerase chain reaction (RT-PCR). A comprehensive bioinformatics analysis using public databases (Stanford SOURCE Search, Integrated Cartilage Gene Database, Mouse Genome Informatics, and NCBI UniGene) was undertaken to investigate the relationship between cardiovascular development and each of twentyeight genes affected by Nell1. Nell1-defi cient mice have signifi cantly enlarged hearts (particularly the heart width), dramatically reduced blood fl ow out of the heart and unexpanded lungs. Isolation of total RNAs from hearts of adult (control and heterozygote) and fetal (control and homozygous mutant) mice have been completed and RT-PCR assays are in progress. The bioinformatics analysis showed that the majority of genes with reduced expression in Nell1-defi cient mice are normally expressed in the heart (79%; 22/28), blood vessels (71%; 20/28) and bone marrow (61%; 17/28). Moreover, mouse mutations in seven of these genes (Col15a1, Osf-2, Bmpr1a, Pkd1, Mfge8, Ptger4, Col5a1) manifest abnormalities in cardiovascular development. These data demonstrate for the fi rst time that Nell1 has a role in early mammalian cardiovascular development, mediated by its regulation of ECM proteins necessary for normal cell growth and differentiation. In addition, understanding the mechanisms by which Nell1 and its associated ECM genes affect the cardiovascular system can provide future strategies for the treatment of heart and blood vessel defects.

Liu, L. Y.; Culiat, C.

2007-01-01T23:59:59.000Z

456

Location of marker genes on definite chromosomes of Gossypium hirsutum L  

E-Print Network [OSTI]

ratios of the various factors, both in the ~1's and in ths eelfa, were st~ died for Che possi- bility of linkag? of one or r~e genes with an intex change colhplexo The Pl orosses and selfs wexo made in the green? hous?at Cho Beasley Laboratory durir...O pxogeny rows including selfed plants wexe available for study during the sum-. . . or of 1~ The technique employed tc detect linkage of one or more genes with an interchange complex may be more easily understood by following the diagrams in Plgures 1...

Abedi, Mohammad Dgavad

1957-01-01T23:59:59.000Z

457

Height modification in grain sorghum lines homozygous for four major height genes  

E-Print Network [OSTI]

HEIGHT MODIFICATION IN GRAIN SORGHUM LINES HOMOZYGOUS FOR FOUR MAJOR HEIGHT GENES A Thesis by TOMMY EARL THOMPSON Approved as to style and content by: (Chairman of~Gommittge) ead o Department) c~~' (Member) r/ ?. cl + ' r EM '7Z' (Member...) January 1970 95Z941 111 AB S T RA C T Height "!odification i i Grain Sorghum Lines Homozygous for Four Flajor Height Genes. (January, 1970) Tommy E. I'hompson, B. S. , Te;&as ASFI University Directed by: Dr. K. F. Schertz Height in grain sorghum...

Thompson, Tommy Earl

1970-01-01T23:59:59.000Z

458

Effect of a "major" dwarfing gene on grain yield and other agronomic traits in oat  

E-Print Network [OSTI]

EFFECT OF A "MAJOR" DWARFING GENE ON GRAIN YIELD AND OTHER AGRONOMIC TRAITS IN OAT A Thesis by JULIANO LUIZ DE ALMEIDA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1994 Major Subject: Plant Breeding EFFECT OF A "MAJOR" DWARFING GENE ON GRAIN YIELD AND OTHER AGRONOMIC TRAITS IN OAT A Thesis by JULIANO LUIZ DE ALMEIDA Submitted to Texas A&M University in partial fulfillment...

Almeida, Juliano Luiz de

2012-06-07T23:59:59.000Z

459

Gene co-expression network analysis in Rhodobacter capsulatus and application to comparative expression analysis of Rhodobacter sphaeroides  

SciTech Connect (OSTI)

The genus Rhodobacter contains purple nonsulfur bacteria found mostly in freshwater environments. Representative strains of two Rhodobacter species, R. capsulatus and R. sphaeroides, have had their genomes fully sequenced and both have been the subject of transcriptional profiling studies. Gene co-expression networks can be used to identify modules of genes with similar expression profiles. Functional analysis of gene modules can then associate co-expressed genes with biological pathways, and network statistics can determine the degree of module preservation in related networks. In this paper, we constructed an R. capsulatus gene co-expression network, performed functional analysis of identified gene modules, and investigated preservation of these modules in R. capsulatus proteomics data and in R. sphaeroides transcriptomics data. Results: The analysis identified 40 gene co-expression modules in R. capsulatus. Investigation of the module gene contents and expression profiles revealed patterns that were validated based on previous studies supporting the biological relevance of these modules. We identified two R. capsulatus gene modules preserved in the protein abundance data. We also identified several gene modules preserved between both Rhodobacter species, which indicate that these cellular processes are conserved between the species and are candidates for functional information transfer between species. Many gene modules were non-preserved, providing insight into processes that differentiate the two species. In addition, using Local Network Similarity (LNS), a recently proposed metric for expression divergence, we assessed the expression conservation of between-species pairs of orthologs, and within-species gene-protein expression profiles. Conclusions: Our analyses provide new sources of information for functional annotation in R. capsulatus because uncharacterized genes in modules are now connected with groups of genes that constitute a joint functional annotation. We identified R. capsulatus modules enriched with genes for ribosomal proteins, porphyrin and bacteriochlorophyll anabolism, and biosynthesis of secondary metabolites to be preserved in R. sphaeroides whereas modules related to RcGTA production and signalling showed lack of preservation in R. sphaeroides. In addition, we demonstrated that network statistics may also be applied within-species to identify congruence between mRNA expression and protein abundance data for which simple correlation measurements have previously had mixed results.

Pena-Castillo, Lourdes; Mercer, Ryan; Gurinovich, Anastasia; Callister, Stephen J.; Wright, Aaron T.; Westbye, Alexander; Beatty, J. T.; Lang, Andrew S.

2014-08-28T23:59:59.000Z

460

Use of gene probes to assess the impact and effectiveness of aerobic in situ bioremediation of TCE  

SciTech Connect (OSTI)

Gene probe hybridization was used to determine distribution and expression of co-metabolic genes at a contaminated site as it underwent in situ methanotrophic bioremediation of trichloroethylene (TCE). The bioremediation strategies tested included a series of air, air:methane, and air:methane:nutrient pulses of the test plot using horizontal injection wells. During the test period, the levels of TCE reduced drastically in almost all test samples. Sediment core samples (n = 367) taken from 0 m (surface)-43 m depth were probed for gene coding for methanotrophic soluble methane monooxygenase (sMMO) and heterotrophic toluene dioxygenase (TOD), which are known to co-metabolize TCE. The same sediment samples were also probed for genes coding for methanol dehydrogenase (MDH) (catalyzing the oxidation of methanol to formaldehyde) to assess specifically changes in methylotrophic bacterial populations in the site. Gene hybridization results showed that the frequency of detection of sMMO genes were stimulated approximately 250% following 1% methane:air (v/v) injection. Subsequent injection of 4% methane:air (v/v) resulted in an 85% decline probably due to nutrient limitations, since addition of nutrients (gaseous nitrogen and phosphorus) thereafter caused an increase in the frequency of detection of sMMO genes. Detection of TOD genes declined during the process, and eventually they were non-detectable by the final treatment, suggesting that methanotrophs displaced the TOD gene containing heterotrophs. Active transcription of sMMO and TOD was evidenced by hybridization to mRNA. These analyses combined with results showing the concomitant decline in TCE concentrations, increases in chloride concentration and increases in methanotroph viable counts, provide multiple lines of evidence that TCE remediation was caused specifically by methanotrophs. Our results suggest that sMMO genes are responsible for most, if not all, of the observed biodegradation of TCE. This study demonstrates that the use of nucleic acid analytical methods provided a gene specific assessment of the effects of in situ treatment technologies.

Hazen, Terry C.; Chakraborty, Romy; Fleming, James M.; Gregory, Ingrid R.; Bowman, John P.; Jimenez, Luis; Zhang, Dai; Pfiffner, Susan M.; Brockman, Fred J.; Sayler, Gary S.

2009-03-15T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Multi-walled carbon nanotube-induced gene expression in the mouse lung: Association with lung pathology  

SciTech Connect (OSTI)

Due to the fibrous shape and durability of multi-walled carbon nanotubes (MWCNT), concerns regarding their potential for producing environmental and human health risks, including carcinogenesis, have been raised. This study sought to investigate how previously identified lung cancer prognostic biomarkers and the related cancer signaling pathways are affected in the mouse lung following pharyngeal aspiration of well-dispersed MWCNT. A total of 63 identified lung cancer prognostic biomarker genes and major signaling biomarker genes were analyzed in mouse lungs (n = 80) exposed to 0, 10, 20, 40, or 80 {mu}g of MWCNT by pharyngeal aspiration at 7 and 56 days post-exposure using quantitative PCR assays. At 7 and 56 days post-exposure, a set of 7 genes and a set of 11 genes, respectively, showed differential expression in the lungs of mice exposed to MWCNT vs. the control group. Additionally, these significant genes could separate the control group from the treated group over the time series in a hierarchical gene clustering analysis. Furthermore, 4 genes from these two sets of significant genes, coiled-coil domain containing-99 (Ccdc99), muscle segment homeobox gene-2 (Msx2), nitric oxide synthase-2 (Nos2), and wingless-type inhibitory factor-1 (Wif1), showed significant mRNA expression perturbations at both time points. It was also found that the expression changes of these 4 overlapping genes at 7 days post-exposure were attenuated at 56 days post-exposure. Ingenuity Pathway Analysis (IPA) found that several carcinogenic-related signaling pathways and carcinogenesis itself were associated with both the 7 and 11 gene signatures. Taken together, this study identifies that MWCNT exposure affects a subset of lung cancer biomarkers in mouse lungs. - Research Highlights: > Multi-Walled Carbon Nanotubes affect lung cancer biomarkers in mouse lungs. > The results suggest potentially harmful effects of MWCNT exposure on human lungs. > The results could potentially be used for the medical surveillance of workers.

Pacurari, M. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Qian, Y., E-mail: yaq2@cdc.gov [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Porter, D.W.; Wolfarth, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Wan, Y.; Luo, D. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Ding, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Castranova, V. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Guo, N.L., E-mail: lguo@hsc.wvu.edu [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506-9190 (United States)

2011-08-15T23:59:59.000Z

462

TCDD dysregulation of 13 AHR-target genes in rat liver  

SciTech Connect (OSTI)

Despite several decades of research, the complete mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other xenobiotic agonists of the aryl hydrocarbon receptor (AHR) cause toxicity remains unclear. While it has been shown that the AHR is required for all major manifestations of toxicity, the specific downstream changes involved in the development of toxic phenotypes remain unknown. Here we examine a panel of 13 genes that are AHR-regulated in many species and tissues. We profiled their hepatic mRNA abundances in two rat strains with very different sensitivities to TCDD: the TCDD-sensitive LongEvans (Turku/AB; LE) and the TCDD-resistant Han/Wistar (Kuopio; H/W). We evaluated doses ranging from 0 to 3000 ?g/kg at 19 h after TCDD exposure and time points ranging from 1.5 to 384 h after exposure to 100 ?g/kg TCDD. Twelve of 13 genes responded to TCDD in at least one strain, and seven of these showed statistically significant inter-strain differences in the time course analysis (Aldh3a1, Cyp1a2, Cyp1b1, Cyp2a1, Fmo1, Nfe2l2 and Nqo1). Cyp2s1 did not respond to TCDD in either rat strain. Five genes exhibited biphasic responses to TCDD insult (Ahrr, Aldh3a1, Cyp1b1, Nfe2l2 and Nqo1), suggesting a secondary event, such as association with additional transcriptional modulators. Of the 12 genes that responded to TCDD during the doseresponse analysis, none had an ED{sub 50} equivalent to that of Cyp1a1, the most sensitive gene in this study, while nine genes responded to doses at least 10100 fold higher, in at least one strain (Ahrr (LE), Aldh3a1 (both), Cyp1a2 (both), Cyp1b1 (both), Cyp2a1 (LE), Inmt (both), Nfe2l2 (LE), Nqo1 (LE) and Tiparp (both)). These data shed new light on the association of the AHR target genes with TCDD toxicity, and in particular the seven genes exhibiting strain-specific differences represent strong candidate mediators of Type-II toxicities. - Highlights: NanoString measured hepatic mRNA molecules following TCDD treatment. TCDD-sensitive LongEvans and TCDD-resistant Han/Wistar rats were compared. Time courses and dose responses were analyzed for AHR-core gene changes. 7 genes displayed inter-strain mRNA differences at times after TCDD exposure. 2 of the AHR-core genes had significant inter-strain differences in their TCDD ED{sub 50}.

Watson, John D., E-mail: john.watson@oicr.on.ca [Ontario Institute for Cancer Research, Department of Informatics and Bio-computing Program, Toronto (Canada); Prokopec, Stephenie D., E-mail: stephenie.prokopec@oicr.on.ca [Ontario Institute for Cancer Research, Department of Informatics and Bio-computing Program, Toronto (Canada); Smith, Ashley B., E-mail: ashleyblaines@gmail.com [Ontario Institute for Cancer Research, Department of Informatics and Bio-computing Program, Toronto (Canada); Okey, Allan B., E-mail: allan.okey@utoronto.ca [Department of Pharmacology and Toxicology, University of Toronto, Toronto (Canada); Pohjanvirta, Raimo, E-mail: raimo.pohjanvirta@helsinki.fi [Laboratory of Toxicology, National Institute for Health and Welfare, Kuopio (Finland); Department of Food Hygiene and Environmental Health, University of Helsinki, Helsinki (Finland); Boutros, Paul C., E-mail: paul.boutros@oicr.on.ca [Ontario Institute for Cancer Research, Department of Informatics and Bio-computing Program, Toronto (Canada); Department of Pharmacology and Toxicology, University of Toronto, Toronto (Canada); Department of Medical Biophysics, University of Toronto, Toronto (Canada)

2014-02-01T23:59:59.000Z

463

Characterization of protein binding to the psbAII promoter region in Synechococcus sp. strain PCC 7942 and its role in light regulated gene expression  

E-Print Network [OSTI]

intensity. Translational gene fusions between each of the psbA genes and a truncated Escherichia coli lacZ gene were prepared as reporters for psbA gene activity (35). P-galactosidase assays of strains carrying these fusions show that as light intensity... decreases from 600 ttE m 2 s-I to 2 ttE m 2 s I, expression of the psbAI gene fusion increases 800%, whereas expression of the psbAII and psbAIII gene fusions decreases 90% (35). To determine if light availability affects the ratio of the two forms...

Dickerson, Naoma Suzanne

2012-06-07T23:59:59.000Z

464

Knockdown of the Dyslexia-Associated Gene Kiaa0319 Impairs Temporal Responses to Speech Stimuli in Rat Primary Auditory Cortex  

E-Print Network [OSTI]

Knockdown of the Dyslexia-Associated Gene Kiaa0319 Impairs Temporal Responses to Speech Stimuli in 15 school age children have dyslexia, which is characterized by phoneme-processing problems and difficulty learning to read. Dyslexia is associated with mutations in the gene KIAA0319. It is not known

Kilgard, Michael P.

465

Effect of Amino Acid Subsititution in Set1 on Histone H3 Methylation and Gene Silencing in Saaccharomyces Cerevisiae  

E-Print Network [OSTI]

EFFECT OF AMINO ACID SUBSITITUTION IN SET1 ON HISTONE H3 METHYLATION AND GENE SILENCING IN SAACCHAROMYCES CEREVISIAE A Senior Honors Thesis by MORGAN CHATEAU Submitted to the Office...3 Methylation and Gene Silencing in Saccharomyces cerevisiae (April 2008) Morgan Chateau Department of Biochemistry and Biophysics Texas A&M University Fellows Advisor: Associate Professor Dr. Mary Bryk Department of Biochemistry...

Chateau, Morgan

2008-08-24T23:59:59.000Z

466

Abscisic acid-dependent and -independent expression of the carrot LEA class gene Dc3 in transgenic tobacco seedlings  

E-Print Network [OSTI]

We studied the expression of three promoter deletion mutants (A218, A599, and A1312) of the Late Embryo Abundant (LEA) class gene Dc3 fused to the reporter gene, B-glucuronidase (GUS) in 14 d old transgenic tobacco seedlings. Seedlings were...

Siddiqui, Najeeb Ullah

1997-01-01T23:59:59.000Z

467

Structure and expression of the maize (Zea mays L.) SUN-domain protein gene family: evidence for the existence of  

E-Print Network [OSTI]

Structure and expression of the maize (Zea mays L.) SUN- domain protein gene family: evidence for the existence of two divergent classes of SUN proteins in plants Murphy et al. Murphy et al. BMC Plant Biology Access Structure and expression of the maize (Zea mays L.) SUN-domain protein gene family: evidence

Bass, Hank W.

468

Polymorphisms of the acid sensing histidine kinase gene arsS in Helicobacter pylori populations from anatomically distinct gastric sites  

E-Print Network [OSTI]

Polymorphisms of the acid sensing histidine kinase gene arsS in Helicobacter pylori populations 2012 Available online 30 August 2012 Keywords: Helicobacter pylori arsS Polymorphism Homopolymeric as environmental or host conditions change. Unusual among Helicobacter pylori phase variable or contingency genes

Forsyth, Mark

469

Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout  

E-Print Network [OSTI]

Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish; accepted 16 October 2002 Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) is a widespread in zebrafish and rainbow trout that dioxin increases expression of this EF-hand calcium-binding protein gene

Tullos, Desiree

470

Development of ChillPeach genomic tools and identification of cold-responsive genes in peach fruit  

E-Print Network [OSTI]

or China, or export to other countries can require a lengthy storage period. Also, the global industry canDevelopment of ChillPeach genomic tools and identification of cold-responsive genes in peach fruit and used in a pilot experiment to identify differentially expressed genes in cold-treated compared

Crisosto, Carlos H.

471

The Fission Yeast Copper-sensing Transcription Factor Cuf1 Regulates the Copper Transporter Gene Expression through an  

E-Print Network [OSTI]

The Fission Yeast Copper-sensing Transcription Factor Cuf1 Regulates the Copper Transporter Gene of copper transport is essential for copper homeostasis and growth in yeast. Analysis of regulatory regions in the promoter of the ctr4 copper transporter gene in fission yeast Schizosaccharomyces pombe re- veals

Labbé, Simon

472

The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning  

E-Print Network [OSTI]

and molecular studies have suggested that the UNUSUAL FLORAL ORGANS (UFO) gene, from Arabidopsis thaliana hybridization using genes expressed early in ¯oral development as probes indicate that UFO controls growth of young ¯oral primordia. Transgenic constructs were used to provide evidence that UFO regulates ¯oral

Haughn, George

473

In Vivo Identification of Solar Radiation-Responsive Gene Network: Role of the p38 Stress-Dependent Kinase  

E-Print Network [OSTI]

In Vivo Identification of Solar Radiation-Responsive Gene Network: Role of the p38 Stress Solar radiation is one of the most common threats to the skin, with exposure eliciting a specific 44K) to study epidermis gene expression in vivo in skin exposed to simulated solar radiation (SSR

Paris-Sud XI, Université de

474

* Corresponding author. : Primary student contributors. On Building a Quantitative Food-Disease-Gene Network  

E-Print Network [OSTI]

nutrients), diseases, and genes [16]. For instance, soy products and green tea have been two to the MEDLINE database on "soy and cancer" renders a total of 1,287 articles, and a search on "green tea: (1) given a pair of entities, e.g., green tea and cancer, different studies might report different

Yang, Hui

475

Projecting 2D Gene Expression Data Into 3D and 4D Space  

E-Print Network [OSTI]

imaging of wholemount stained sam- ples. The two-dimensional images thus generated are, in fact games typically generate virtual 3D objects by texture mapping an image onto a 3D polygonal frame mapping images of gene expression data onto b-spline based embryo models. This approach, known as UV

Vize, Peter D.

476

Parallel MATLAB at VT Gene Cliff (AOE/ICAM -ecliff@vt.edu )  

E-Print Network [OSTI]

Parallel MATLAB at VT Gene Cliff (AOE/ICAM - ecliff@vt.edu ) Justin Krometis (ARC/ICAM - jkrometis Mathematics 1 / 35 #12;MATLAB Parallel Computing Introduction Programming Models Execution Example: Quadrature Conclusion 2 / 35 #12;INTRO: Parallel MATLAB Parallel MATLAB is an extension of MATLAB that takes advantage

Crawford, T. Daniel

477

Peptide functionalized nanoparticles for nonviral gene Rachel M. Levine,a  

E-Print Network [OSTI]

of viruses. Many different materials and constructs have been investigated as synthetic gene delivery in this review are included in Fig. 1. Functionalization with poly- ethylene glycol (PEG) for stealth and Materials Science Department at the University of Minnesota. She received her B.S.E in Chemical Engineering

Kokkoli, Efie

478

Mosaic Analysis of GL2 Gene Expression and Cell Layer Autonomy During the Specification of  

E-Print Network [OSTI]

ARTICLE Mosaic Analysis of GL2 Gene Expression and Cell Layer Autonomy During the Specification: Homozygous glabra2 (gl2) mutant Arabidop- sis thaliana Landsberg erecta plants with only a few rudimentary single spiked trichomes on the leaf margin were transformed with a genomic clone of GL2, resulting

Murray, J.A.H.

479

Methods in comparative genomics: genome correspondence, gene identification and motif discovery  

E-Print Network [OSTI]

1 Methods in comparative genomics: genome correspondence, gene identification and motif discovery@mit.edu, nickp@genome.wi.mit.edu, bwb@genome.wi.mit.edu, bab@mit.edu, lander@wi.mit.edu (1) MIT/Whitehead Institute Center for Genome Research, 320 Charles St., Cambridge MA 02139 (2) MIT Computer Science

Kellis, Manolis

480

ABSTRACT Genomics and bioinformatics have the vast potential to identify genes that cause disease by investigating  

E-Print Network [OSTI]

ABSTRACT Genomics and bioinformatics have the vast potential to identify genes that cause disease by investigating whole-genome databases. Comparison of an individual's geno- type with a genomic database these metabolic profiles with genomic, expression, and proteomic databases. Application of the knowledge of indi

Hammock, Bruce D.

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Diverse RNA processing pathways important for post-transcriptional gene regulation  

E-Print Network [OSTI]

Cis-acting elements in 3' untranslated regions (UTRs) of mRNAs are crucial to the regulation of gene expression. Animal microRNAs (miRNAs) each target hundreds of mRNAs, which are recognized by pairing to nucleotides 2-7 ...

Jan, Calvin H

2010-01-01T23:59:59.000Z

482

a 50% reduction in Prlr gene dose, provides strong evidence for PRL being the mediator  

E-Print Network [OSTI]

a 50% reduction in Prlr gene dose, provides strong evidence for PRL being the mediator of pregnancy adaptation initiated early in pregnancy and mediated by PRL. Pregnancy is associated with several other transient alterations in mater- nal physiological functions, many of which can be affected by PRL and

Kenig, Fabien

483

Application of Logic Synthesis Toward the Inference and Control of Gene Regulatory Networks  

E-Print Network [OSTI]

. This technique determines a BN (or family of BNs) to describe the GRN and is validated on a synthetic network and the p53 network. The first two techniques assume binary valued gene expression data. In the third technique, we utilize continuous (analog...

Lin, Pey Chang K

2013-06-27T23:59:59.000Z

484

Activation Tagging of a Dominant Gibberellin Catabolism Gene (GA 2-oxidase) from Poplar That Regulates  

E-Print Network [OSTI]

in forestry; however, they may also provide significant advantages (Bradshaw and Strauss, 2001). Stands may to reduced bending and leaning (reaction wood) and be less prone to wind- fall. Dwarfing genes might to power lines, are less prone to being blown down onto structures, and impose on neighboring homes

485

Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human  

E-Print Network [OSTI]

Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human, 2014) This paper describes a microfluidics-based workflow for geneti- cally targeted isolation that enables genetically targeted cultivation of microorganisms through a combination of microfluidics and on

Ismagilov, Rustem F.

486

Gene expression networks underlying retinoic acidinduced differentiation of acute promyelocytic leukemia cells  

E-Print Network [OSTI]

with the differentiation and pro- liferation status of the NB4 cells. The time courses of their modulation were interesting- sponse- (PML/RARA) fusion gene, which was generated as a result of the APL-specific chromosome/RARA disrupts the normal location of the PML nuclear body or oncogenic domains (PODs)2,3 and interferes

Tian, Weidong

487

Altered Stra13 and Dec2 circadian gene expression in hypoxic cells  

SciTech Connect (OSTI)

The circadian system regulates rhythmically most of the mammalian physiology in synchrony with the environmental light/dark cycle. Alteration of circadian clock gene expression has been associated with tumour progression but the molecular links between the two mechanisms remain poorly defined. Here we show that Stra13 and Dec2, two circadian transcriptional regulators which play a crucial role in cell proliferation and apoptosis are overexpressed and no longer rhythmic in serum shocked fibroblasts treated with CoCl{sub 2,} a substitute of hypoxia. This effect is associated with a loss of circadian expression of the clock genes Rev-erb{alpha} and Bmal1, and the clock-controlled gene Dbp. Consistently, cotransfection assays demonstrate that STRA13 and DEC2 both antagonize CLOCK:BMAL1 dependent transactivation of the Rev-erb{alpha} and Dbp promoters. Using a transplantable osteosarcoma tumour model, we show that hypoxia is associated with altered circadian expression of Stra13, Dec2, Rev-erb{alpha}, Bmal1 and Dbp in vivo. These observations collectively support the notion that overexpression of Stra13 and Dec2 links hypoxia signalling to altered circadian clock gene expression.

Guillaumond, Fabienne; Lacoche, Samuel; Dulong, Sandrine; Grechez-Cassiau, Aline [Universite de Nice-Sophia Antipolis, CNRS FRE3094, 28 Av. Valrose, 06108 Nice (France); Filipski, Elisabeth; Li, Xiao-Mei; Levi, Francis [Universite Paris-Sud, INSERM U776, Hopital Paul Brousse, 14 Av. P.V. Couturier, 94800 Villejuif (France); Berra, Edurne [Cell Biology and Stem Cells Unit, CIC BioGUNE, Technologic Park of Bizkaia, 48160-Derio (Spain); Delaunay, Franck [Universite de Nice-Sophia Antipolis, CNRS FRE3094, 28 Av. Valrose, 06108 Nice (France); Teboul, Michele [Universite de Nice-Sophia Antipolis, CNRS FRE3094, 28 Av. Valrose, 06108 Nice (France)], E-mail: teboulm@unice.fr

2008-05-16T23:59:59.000Z

488

Regulation of E. coli SOS mutagenesis by dimeric intrinsically disordered umuD gene products  

E-Print Network [OSTI]

Products of the umuD gene in E. coli are involved in regulating the timing of error-free DNA repair processes and mutagenic translesion DNA synthesis (TLS) during the SOS response to DNA damage. Homodimeric UmuD2 is ...

Simon, Sharotka M. (Sharotka Maria)

2007-01-01T23:59:59.000Z

489

Genetic diversity in chlorella viruses flanking kcv, a gene that encodes a potassium ion channel protein  

E-Print Network [OSTI]

Genetic diversity in chlorella viruses flanking kcv, a gene that encodes a potassium ion channel Received 23 March 2004; accepted 27 May 2004 Abstract The chlorella virus PBCV-1 encodes a 94-amino acid additional chlorella viruses and transcription in two of these viruses, as well as the effect of the three

Graves, Michael V.

490

A Microfluidic Device for Temporally Controlled Gene Expression and Long-Term Fluorescent Imaging in  

E-Print Network [OSTI]

A Microfluidic Device for Temporally Controlled Gene Expression and Long-Term Fluorescent Imaging of the cell cycle. Over the past ten years, microfluidic techniques in cell biology have emerged that allow a microfluidic flow cell to grow Saccharomyces Cerevisiae for more than 8 generations (

Siggia, Eric

491

DRD2 Gene Transfer Into the Nucleus Accumbens Core of the Alcohol Preferring and Nonpreferring Rats  

E-Print Network [OSTI]

in alcohol intake in Sprague Dawley rats. This overexpression of DRD2 reduced alcohol consumption in a two that high levels of DRD2 are causally associated with a reduction in alcohol consumption and may serve Tomography (PET) Gene Therapy. ETHANOL STIMULATES BOTH dopamine (DA) neurons and DA release in the rat

Homes, Christopher C.

492

A variably occupied CTCF binding site in the Ultrabithorax gene in the Drosophila Bithorax Complex  

E-Print Network [OSTI]

:22932303. 664 28 28. Whitfield WG, Millar SE, Saumweber H, Frasch M, Glover DM. 1988. 665 Cloning of a gene encoding an antigen associated with the centrosome in 666 Drosophila. J. Cell Sci. 89 ( Pt 4):467480. 667 29. Birch-Machin I, Gao S, Huen D, Mc...

Magbanua, Jose Paolo; Runneburger, Estelle; Russell, Steven; White, Robert

2014-11-03T23:59:59.000Z

493

Population Structure and Gene Flow of the Yellow Anaconda (Eunectes notaeus) in Northern Argentina  

E-Print Network [OSTI]

Population Structure and Gene Flow of the Yellow Anaconda (Eunectes notaeus) in Northern Argentina´n Biodiversidad ­ Argentina, Buenos Aires, Argentina, 4 Wildlife Conservation Society, Bronx, New York, United plan in Argentina, so information regarding population structuring can be helpful for determination

Shaffer, H. Bradley

494

GENETIC POPULATION STRUCTURE, GENE FLOW, AND EVOLUTIONARY HISTORY OF SELECTED ORNAMENTAL FISH  

E-Print Network [OSTI]

GENETIC POPULATION STRUCTURE, GENE FLOW, AND EVOLUTIONARY HISTORY OF SELECTED ORNAMENTAL FISH dispersal distances in the Red Sea 12 Chapter 3 Comparative genetic population structure of two reef fishes and the demographic connectivity in the endemic fish species of the Red Sea Larabicus quadrilineatus, and in the two

495

Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting  

E-Print Network [OSTI]

/parallel synthesis that creates a large library of materials and allows identification of the best. Gabrielson, Hua Lu, Jianjun Cheng* Department of Materials Science and Engineering, University of Illinois of the gene cargos, it meanwhile causes severe associated cytotoxicities [7e9]. Excessive positive charges can

Cheng, Jianjun

496

PROGRESS IN THE EPIDEMIOLOGICAL UNDERSTANDING OF GENE-ENVIRONMENT INTERACTIONS IN MAJOR DISEASES: CANCER  

E-Print Network [OSTI]

PROGRESS IN THE EPIDEMIOLOGICAL UNDERSTANDING OF GENE- ENVIRONMENT INTERACTIONS IN MAJOR DISEASES chemical, physical and biological carcinogenic agents have been identified in the working environment and in the overall environment. The chain of events from environmental exposures to cancer requires hundreds

Boyer, Edmond

497

A Novel Approach to Determine Normal Variation in Gene Expression Data  

E-Print Network [OSTI]

and regulation. In the last decade the development of mouse models for cancer, dia- betes, neuro to experimental noise in each of the mice and then mines for normal variance among the identical mice-throughput gene expression has become an important tool to study transcriptional activity in a variety of bio

Zaki, Mohammed Javeed

498

Identification and characterization of the gene encoding the Acidobacterium capsulatum major sigma factor  

E-Print Network [OSTI]

, Wisconsin 53706, USA c McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison. capsulatum major sigma factor and the gene product is active in E. coli. © 2006 Elsevier B.V. All rights isolated from acid mine drainage (Kishimoto et al., 1991). A. capsulatum is a member of the Acidobacteria

Handelsman, Jo

499

A survey of anthracnose resistant sorghum germplasm lines to identify additional resistance genes  

E-Print Network [OSTI]

and their inheritance characterized. The objectives of this study were (1) to determine if different sources of genetic resistance exist among a selected set of 13 resistant sorghum germplasm lines, and (2) to determine the inheritance of the different resistance genes...

Wiltse, Curtis Craig

2012-06-07T23:59:59.000Z

500

Effects of exercise or oocyte heat shock on embryo development and gene expression in the horse  

E-Print Network [OSTI]

experiments were examined for HSP70 gene expression by real time RT-PCR. Exercised mares ovulated significantly smaller follicles, 39.8 vs. 41.5 mm diameter, and ovulated later after being given PGF2?, 8.5 vs. 9.2 d. Twenty-two embryos (22/35) were recovered...

Mortensen, Christopher John

2009-05-15T23:59:59.000Z