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We encourage you to perform a real-time search of NLEBeta
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1

Injectivity Test At Steamboat Springs Area (Combs, Et Al., 1999) | Open  

Open Energy Info (EERE)

Steamboat Springs Area (Combs, Et Steamboat Springs Area (Combs, Et Al., 1999) Exploration Activity Details Location Steamboat Springs Area Exploration Technique Injectivity Test Activity Date Usefulness not indicated DOE-funding Unknown Notes Part of the injection testing used downhole packers for isolating various zones and evaluating their permeability. By running the packers into the hole on N-rod ( 2.75"+K610 OD), the annulus was roughly the same cross-sectional area as the inside of the pipe. It was then possible to inject into either the zone above the packer or the one below, and compare the infectivity of those intervals. References Jim Combs, John T. Finger, Colin Goranson, Charles E. Hockox Jr., Ronald D. Jacobsen, Gene Polik (1999) Slimhole Handbook- Procedures And Recommendations For Slimhole Drilling And Testing In Geothermal Exploration

2

Slimhole Handbook- Procedures And Recommendations For Slimhole Drilling And  

Open Energy Info (EERE)

Slimhole Handbook- Procedures And Recommendations For Slimhole Drilling And Slimhole Handbook- Procedures And Recommendations For Slimhole Drilling And Testing In Geothermal Exploration Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Report: Slimhole Handbook- Procedures And Recommendations For Slimhole Drilling And Testing In Geothermal Exploration Details Activities (27) Areas (8) Regions (0) Abstract: No abstract prepared. Author(s): Jim Combs, John T. Finger, Colin Goranson, Charles E. Hockox Jr., Ronald D. Jacobsen, Gene Polik Published: Geothermal Technologies Legacy Collection, 1999 Document Number: Unavailable DOI: Unavailable Source: View Original Report Acoustic Logs At Newberry Caldera Area (Combs, Et Al., 1999) Acoustic Logs At Steamboat Springs Area (Combs, Et Al., 1999) Core Analysis At Fort Bliss Area (Combs, Et Al., 1999)

3

Injectivity Test At Newberry Caldera Area (Combs, Et Al., 1999) | Open  

Open Energy Info (EERE)

Newberry Caldera Area (Combs, Et Al., 1999) Newberry Caldera Area (Combs, Et Al., 1999) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Injectivity Test At Newberry Caldera Area (Combs, Et Al., 1999) Exploration Activity Details Location Newberry Caldera Area Exploration Technique Injectivity Test Activity Date Usefulness useful DOE-funding Unknown Notes After circulating the mud out of the hole and replacing it with clear water, we attempted two injection tests; one into the open hole section (51 16'- 5360') below the HQ liner, and one into the annulus outside the uncemented part (2748' - -4800') of the liner. References Jim Combs, John T. Finger, Colin Goranson, Charles E. Hockox Jr., Ronald D. Jacobsen, Gene Polik (1999) Slimhole Handbook- Procedures And Recommendations For Slimhole Drilling And Testing In Geothermal Exploration

4

Acoustic Logs At Newberry Caldera Area (Combs, Et Al., 1999) | Open Energy  

Open Energy Info (EERE)

Acoustic Logs At Newberry Caldera Area (Combs, Et Al., 1999) Acoustic Logs At Newberry Caldera Area (Combs, Et Al., 1999) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Acoustic Logs At Newberry Caldera Area (Combs, Et Al., 1999) Exploration Activity Details Location Newberry Caldera Area Exploration Technique Acoustic Logs Activity Date Usefulness could be useful with more improvements DOE-funding Unknown Notes The acoustic borehole televiewer (BHTV) was run twice in the wellbore with limited success. There were several problems with the tool's fimctions, but images were successfully obtained over the interval from 2748' to 3635'. References Jim Combs, John T. Finger, Colin Goranson, Charles E. Hockox Jr., Ronald D. Jacobsen, Gene Polik (1999) Slimhole Handbook- Procedures And Recommendations For Slimhole Drilling And Testing In Geothermal Exploration

5

Slimhole Handbook- Procedures and Recommendations for Slimhole Drilling and  

Open Energy Info (EERE)

Slimhole Handbook- Procedures and Recommendations for Slimhole Drilling and Slimhole Handbook- Procedures and Recommendations for Slimhole Drilling and Testing in Geothermal Exploration Jump to: navigation, search OpenEI Reference LibraryAdd to library Report: Slimhole Handbook- Procedures and Recommendations for Slimhole Drilling and Testing in Geothermal Exploration Abstract No abstract prepared. Authors Jim Combs, John T. Finger, Colin Goranson, Charles E. Hockox Jr., Ronald D. Jacobsen and Gene Polik Organization Sandia National Laboratories Published Geothermal Technologies Legacy Collection, 1999 Report Number SAND99-1976 DOI Not Provided Check for DOI availability: http://crossref.org Online Internet link for Slimhole Handbook- Procedures and Recommendations for Slimhole Drilling and Testing in Geothermal Exploration Citation

6

Modeling-Computer Simulations (Combs, Et Al., 1999) | Open Energy  

Open Energy Info (EERE)

Modeling-Computer Simulations (Combs, Et Al., 1999) Modeling-Computer Simulations (Combs, Et Al., 1999) Exploration Activity Details Location Unspecified Exploration Technique Modeling-Computer Simulations Activity Date Usefulness useful DOE-funding Unknown Notes Various models/simulations used to analyze data obtained from slimhole drilling. References Jim Combs, John T. Finger, Colin Goranson, Charles E. Hockox Jr., Ronald D. Jacobsen, Gene Polik (1999) Slimhole Handbook- Procedures And Recommendations For Slimhole Drilling And Testing In Geothermal Exploration Retrieved from "http://en.openei.org/w/index.php?title=Modeling-Computer_Simulations_(Combs,_Et_Al.,_1999)&oldid=387232" Category: Exploration Activities What links here Related changes Special pages Printable version Permanent link Browse properties

7

Static Temperature Survey At Steamboat Springs Area (Combs, Et Al., 1999) |  

Open Energy Info (EERE)

Steamboat Springs Area Steamboat Springs Area (Combs, Et Al., 1999) Exploration Activity Details Location Steamboat Springs Area Exploration Technique Static Temperature Survey Activity Date Usefulness not indicated DOE-funding Unknown Notes Numerous temperature logs were taken with Sandia'splatinum-resistance-thermometer (PRT) tool which along with a Sandia logging truck remained on-site for the entire project. Static temperature logs (no flow in hole) were done with this tool before each series of productiotilnjection tests. References Jim Combs, John T. Finger, Colin Goranson, Charles E. Hockox Jr., Ronald D. Jacobsen, Gene Polik (1999) Slimhole Handbook- Procedures And Recommendations For Slimhole Drilling And Testing In Geothermal Exploration Retrieved from "http://en.openei.org/w/index.php?title=Static_Temperature_Survey_At_Steamboat_Springs_Area_(Combs,_Et_Al.,_1999)&oldid=511162"

8

Slim Holes At International Geothermal Area, Japan (Combs, Et Al., 1999) |  

Open Energy Info (EERE)

Japan (Combs, Et Al., 1999) Japan (Combs, Et Al., 1999) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Slim Holes At International Geothermal Area, Japan (Combs, Et Al., 1999) Exploration Activity Details Location International Geothermal Area Japan Exploration Technique Slim Holes Activity Date Usefulness useful DOE-funding Unknown Notes Based on personal relationships between Maxwell scientists and Japanese geothermal developers, production and injection data from 64 slim holes and 79 large-diameter wells (see table below) at four Japanese geothermal fields (Oguni, Sumikaw~ Takigarni, and Kirishirna) have been obtained. References Jim Combs, John T. Finger, Colin Goranson, Charles E. Hockox Jr., Ronald D. Jacobsen, Gene Polik (1999) Slimhole Handbook- Procedures And

9

In Proc. SPIE 4013-55, UV, Optical, and IR Space Telescopes and Instruments VI, Breckinridge & Jacobsen, eds., Munich, Germany, March 2000. Resolving Piston Ambiguities when Phasing a Segmented Mirror  

E-Print Network [OSTI]

& Jacobsen, eds., Munich, Germany, March 2000. Resolving Piston Ambiguities when Phasing a Segmented Mirror light is insensitive to segment piston errors that are a whole number of waves. If the wavefront sensing range of a wavefront sensor can be extended from on the order of ¢¡¤£ 2 in piston to several waves

Löfdahl, Mats

10

Abene, Cathy 6-3547 Energy Donatucci, Dana 4-8507 Waste Svcs/Recycling (363-6145) Jach, Dan 6-8579 U Construction (221-4269) Allen, John 5-6311 Haz-Mat (799-0712) Drews, Paul 6-0493 East Bank (290-2672) Jacobsen, Brad 5-2378 Energy  

E-Print Network [OSTI]

Abene, Cathy 6-3547 Energy Donatucci, Dana 4-8507 Waste Svcs/Recycling (363-6145) Jach, Dan 6-2692) Kluge, Nick 6-7176 Waste Svcs/Recy Berkowitz, Wendy 4-8886 Finance/Accounting Ford, Robert 5-5527 Energy-2672) Jacobsen, Brad 5-2378 Energy Anderson, Conrad 5-0689 StP/W (HellerH) (328-1586) Durushia, Ann 6-0291 U Svcs

Gulliver, Robert

11

Douglas Jacobsen! NERSC Bioinformatics Computing Consultant  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Running Jobs on Running Jobs on Genepool --- 1 --- February 1 2, 2 013 Structure of the Genepool System --- 2 --- compute n odes gpint n odes high p riority & interac6ve nodes fpga web services database services login n odes filesystems ssh genepool.nersc.gov h=p://...jgi---psf.org User A ccess C ommand L ine S cheduler S ervice Types of Jobs on genepool * Batch - S cheduled ( compute n odes, f pga) - 8,320 c ores f or 7 2,953,280 c ompute h ours p er y ear i n g enepool - use " qsub" t o s ubmit a j ob * Interac@ve - S cheduled (compute n odes s ubset) - 80 c ores p resently, i ncreasing s ize - use " qlogin" t o s ubmit a j ob * Interac@ve - U nscheduled (login n odes, g pints) - 4 login nodes, 27 gpint n odes - ssh t o t he h ost, d irect---use * Services - U nscheduled ( login n odes, g pints, -

12

Douglas Jacobsen! NERSC User Services Group  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Services Group Services Group Using Modules at NERSC --- 1 --- September 10, 2013 NERSC Supported Software * NERSC p rovides a w ide r ange o f s cien=fic a nd c omputer programming s o@ware t o u sers - Scien)fic A pplica)ons: V ASP, A mber, N AMD, ABySS, ... - Compilers: p gi, i ntel, g cc, c ray - Scrip)ng L anguages: perl, p ython, R * and p ackages f or e ach! - SoIware L ibraries: b las/lapack ( MKL), b oost, h df5, n etcdf, ... - U)li)es: gnuplot, g it, m ercurial, 7 zip, c make, . .. - Debuggers & P rofilers: C rayPat, D DT, TotalView, g db, M AP, darshan - Visualiza)on: V isit, P araView, V MD, ... * See complete list: - hVp://www.nersc.gov/users/soIware/ --- 2 --- Software is Managed by Modules * NERSC p rovides m any v ersions o f m any s o@ware packages - To s upport d iverse w orkload o n s ystems * Maintaining

13

Douglas Jacobsen! NERSC Bioinformatics Computing Consultant  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Monitoring and Debugging Jobs on Genepool --- 1 --- February 1 2, 2 013 Checking on your jobs * You've m astered q sub a nd s ubmi9ed y our j obs - now w hat? * Monitoring j obs i...

14

Privatarkiv nr. Tek 20 Einar Sem-Jacobsen, 1878-  

E-Print Network [OSTI]

Frankrike for å få sin flygerutdannelse. Da de kom tilbake til Norge, hadde de med seg to Farman fly, "Njål

Malinnikova, Eugenia

15

Gene Frequency  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Gene Frequency Gene Frequency Name: donna Location: N/A Country: N/A Date: N/A Question: If six fingers is a dominant human trait why do we have only five? Replies: This is simple. There are just not many genes in the human population for six fingers. Steve Sample Look in any high school biology book for what is known as Hardy-Weinberg equilibrium. These two scientists (separately) said that gene frequencies do not change much unless something in the environment selects them over other genes. In other words, unless 6 fingers somehow becomes an advantage, and five-fingered people have less of an advantage, the frequency of six fingered people in the population will not necessarily increase. This is the same reason that recessive traits don't disappear from the population. Also, six fingers is not considered attractive and they may not get as many mates. Also, more people are born with six fingers than you might imagine but just have them amputated shortly after birth.

16

Nominally anhydrous minerals and Earth's deep water cycle Joseph R. Smyth* and Steven D. Jacobsen  

E-Print Network [OSTI]

on the surface, hence oceans and dry land, almost as far back as we can see in geologic time. Oxygen isotope after accretion and differentiation from relatively D-enriched comets [Robert, 2001; Delsemme, 1999

Smyth, Joseph R.

17

Gene expression and evolution  

E-Print Network [OSTI]

Visualization of individual Scr mRNAs during Drosophilaof the homeotic gene Scr associated with a crustacean leg-as in Kosman et al. , 2004. SCR and ABD-B antibodies were

Lemons, Derek Scott

2010-01-01T23:59:59.000Z

18

Nanomedicine for gene therapy  

Science Journals Connector (OSTI)

Viruses are promising vehicles that result in high gene expression level, but issues of safety and virulent nature prevented its extensive use. Therefore, nonviral approach was investigated with the intervention ...

Susan Muthe Alex; Chandra P. Sharma

2013-10-01T23:59:59.000Z

19

CAPnCollar Genes (CNC)  

Science Journals Connector (OSTI)

CNC genes are basic leucine zipper transcription factor... DNA binding protein domains , homeotic genes

2008-01-01T23:59:59.000Z

20

OVARIAN CANCER GENE THERAPY  

Science Journals Connector (OSTI)

Although systemic gene therapy is certainly the ultimate goal for strategies directed towards patient cancer therapy, present problems with systemic vector delivery suggest that initial gene therapy strategies may involve regional approaches directed towards the few specific tumors that exhibit a predominantly regional pattern of spread: ovarian cancers and brain tumors. The model system of metastatic ovarian cancer growing within peritoneal fluid has several advantages of safety and efficacy for retroviral-mediated gene transfer into solid tumors. First, the pathology of metastasis into mesothelial-lined spaces consists of relatively thin tumor plaques with extravasation of cancer cells into the fluid, potentially allowing a reservoir for delivering retroviral vectors to malignant cells. This spreading pattern is in contrast to primary tumors and more solid metastatic sites, where cancer grows as a large three-dimensional mass that could prevent delivery of retroviral vectors or other agents into the majority of tumor cells. In addition, infusion of retroviral vectors into these fluids should produce a greater effect on the growing cells within the fluid (predominantly cancer cells) than on proliferating host cells in regions of the body that do not directly connect to the mesothelial-lined spaces. Second, ovarian cancer provides a model system in which regional therapy could be curative in a high percentage of cases. This is true because ovarian cancer is confined to the peritoneal cavity at patient presentation in 60% of cases. The uptake and expression of the viral vectors can be readily assessed in these model systems because these fluids are readily accessible for cytologic, biochemical, and molecular analysis. Cancer gene therapy strategies include immunotherapy, introduction of drug sensitivity or resistance genes, oncogene inactivation, introduction of cytolytic genes, and tumor suppressor gene replacement. Examples of gene therapy protocols designed to target ovarian cancer include immunotherapy approaches, introduction of cytolytic genes, and tumor suppressor gene therapy approaches (reviewed in Roth and Cristiano22). The BRCA1 gene is mutated in the majority of cases of hereditary breast and ovarian cancer and exhibits loss of heterozygosity (LOH) and/or decreased expression in many sporadic cases.5,6,7,9,11,16,17,30,31 Multiple studies have demonstrated that overexpression of the BRCA1 gene results in growth inhibition and/or cell death, suggesting that BRCA1 can function directly as a growth inhibitor or tumor suppressor.10,21,28,31,33,34 Alternatively, growth inhibition may not be the major or sole mechanism for tumor suppression,13 because BRCA1 also functions during differentiation8,14,15 and may modulate DNA repair.13,27 The antitumor effect may be due to secretion of the BRCA1 gene product and a resulting paracrine inhibitory effect,12 although the precise biochemical function of BRCA1 is controversial and may involve nuclear functions4,26 such as DNA repair27 or transcriptional activation.3,18 Preclinical studies in nude mice xenografts have shown that intraperitoneal injection of retroviral vectors expressing \\{BRCA1sv\\} (a normal splice variant form of BRCA1) can inhibit the growth of established intraperitoneal tumors.10 Control retroviral vectors do not exhibit a significant antitumor effect, indicating that this is not merely a nonspecific effect of retroviral injection, but an effect of BRCA1 gene transfer.10 These studies showed transduction of tumor cells and expression of BRCA1 mRNA and protein following intraperitoneal injection of established intraperitoneal tumors10 or intratumoral injection of subcutaneous tumors (Obermiller and Holt, unpublished data). This article describes the development and phase I testing of BRCA1 gene therapy for the treatment of ovarian cancer.

David L. Tait; Patrice S. Obermiller; Roy A. Jensen; Jeffrey T. Holt

1998-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Nonviral Vectors for Gene Delivery  

E-Print Network [OSTI]

been conducted (http://www.wiley.com/legacy/wileychi/genmed/clinical/). Gene therapies can be categorized on the basis of therapy as gene inhibitors, gene vaccines and gene substitutes. Gene inhibitors (i.e. siRNA) are potent therapies that silence... in formulation design and can be tailored to fit the size and topology of the gene. 1.4.2.1. Natural polymers Over the years, a significant number of natural polymers, such as chitosan 174 , cationic proteins (e.g., polylysine, protamine and histones...

Baoum, Abdulgader Ahmed

2011-04-26T23:59:59.000Z

22

Huntington's disease Between genes and  

E-Print Network [OSTI]

-base stutter in the DNA of the gene concerned. To a large extent, the length of the repeated section determines

Levin, Yan

23

Traits and Multiple Genes  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Traits and Multiple Genes Traits and Multiple Genes Name: Frank Location: N/A Country: N/A Date: N/A Question: Please, could you give me an example of how human traits are controlled by more than one pair of alleles? Replies: Your question is just a bit vague, there are different answers depending on just what your question is. I will answer it in terms of polygenic traits also known as additive alleles. When you think of traits such as skin color, hair color and eye color, or traits where there is a wide range of phenotypes they are usually under the control of more than one pair of alleles. These alleles can even be on different chromosomes! Each pair of additive alleles adds to the phenotype. For instance in the case of skin color, scientists now believe that 3 genes control skin color. You then get 3 sets from your mother and 3 from your father for 6 possibilities. If all 6 of the alleles are for dark skin, you will have the darkest possible skin. If you have 5 dark alleles and one light, you will have very dark skin. If you have all 6 light alleles then you will have the lightest skin possible. Is it possible to have a child that is light skinned when both parents are dark-skinned? Well, not if both have all 6 dark alleles, but if they have some light alleles and the child inherits all of the possible light alleles available, then yes, the child could have lighter skin than either parent. It is now believed that eye color is not simply brown being dominant over blue because how many people do you know that have the same shade of brown or blue eyes? Eye color must also be polygenic.

24

Recessive and Dominant Gene Action  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Recessive and Dominant Gene Action Recessive and Dominant Gene Action Name: Katie Location: N/A Country: N/A Date: N/A Question: What Causes some genes to be ressesive and other genes to be dominant? Replies: Think about the fact that genes code for directions for making proteins. There are many different kinds of proteins in our body-enzymes for regulating metabolism, structural proteins for building our bodies, hormones for regulating processes etc. If the gene for the protein is structural, then it is important to have the right kind and the right amount. If the gene is defective (usually recessive genes are defective, but not always) the right protein will not be made and the structure will either be defective and won't work at all or there won't be enough to maintain the structure. Sometimes you need both genes to be working to get enough of the structure. So a homozygous person will have the strongest structure. A heterozygote would have one gene that is working a may produce enough of the protein to maintain the structure, but maybe not. So in some cases, just having one copy of the dominant (working) gene is enough. If it is a trait for something like eye color, this is not going to cause a defect, just a difference. In this case, being heterozygous or homozgyous for the dominant trait produces the same color of eye. In the case of sickle cell anemia, the recessive gene changes the protein structure of the shape of the red blood cell. If you have one good copy and one bad copy of the gene, some of your cells will be normal and some will be sickle cells. One good copy of the gene gives you enough normal red blood cells to stay healthy. But if you don't have a normal copy, all of your cells have the capability to sickle under certain conditions and this can be fatal. So think of dominant and recessive genes in terms of what they produce and what that protein is supposed to do and then think of what would happen if the dominant gene was able to overtake the effect of the recessive gene.

25

The Honorable Gene Dean  

Office of Legacy Management (LM)

Energy' .' Energy' .' Washington, DC 20585 DE! 14 1gg4 The Honorable Gene Dean \ P.O. Box 1659~ L Huntington, West Virginia 25717 _ ',.. : Dear Mayor Dean: Secretary of Energy Hazel O'Leary has'announced,a new approach ,to openness in the'Department of Energy (DOE) and its communications with the public. In support of this in.itiative, we are pleased,to forward the..enclosed information related to the former Reduction Pilot Plant sitein your jurisdiction that performed work for DOE predecessor agencies. This information is provided.for your information, use,.band retention., DDE's Formerly Utilized Sites Remedial.Action Program is responsible for identification of sitesused by DOE's predecessor agencies, determini,ng theirs current radiological condition and, where it has authority, performing

26

GenePRIMP: A GENE PRediction IMprovement Pipeline for Prokaryotic genomes  

SciTech Connect (OSTI)

We present 'gene prediction improvement pipeline' (GenePRIMP; http://geneprimp.jgi-psf.org/), a computational process that performs evidence-based evaluation of gene models in prokaryotic genomes and reports anomalies including inconsistent start sites, missed genes and split genes. We found that manual curation of gene models using the anomaly reports generated by GenePRIMP improved their quality, and demonstrate the applicability of GenePRIMP in improving finishing quality and comparing different genome-sequencing and annotation technologies.

Pati, Amrita; Ivanova, Natalia N.; Mikhailova, Natalia; Ovchinnikova, Galina; Hooper, Sean D.; Lykidis, Athanasios; Kyrpides, Nikos C.

2010-04-01T23:59:59.000Z

27

Prodigal: Microbial Gene Prediction Software  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Screenshot Screenshot Artemis Screenshot of Prodigal Results Compared with Curated Annotations and other Computational Genefinders for Anaeromyxobacter dehalogenans 2CP-C (Click to enlarge) Prodigal (Prokaryotic Dynamic Programming Genefinding Algorithm) is a microbial (bacterial and archaeal) gene finding program developed at Oak Ridge National Laboratory and the University of Tennessee. Key features of Prodigal include: Speed: Prodigal is an extremely fast gene recognition tool (written in very vanilla C). It can analyze an entire microbial genome in 30 seconds or less. Accuracy: Prodigal is a highly accurate gene finder. It correctly locates the 3' end of every gene in the experimentally verified Ecogene data set (except those containing introns). It possesses a very

28

Whose genes can stomach cancer?  

Science Journals Connector (OSTI)

... a person develops stomach cancer depends partly on their genes, new research suggests. As John Whitfield reports, this discovery could help prevent the disease. El-Omar,E. M. ...

John Whitfield

2000-03-23T23:59:59.000Z

29

Ethics of Gene Therapy Debated  

Science Journals Connector (OSTI)

Ethics of Gene Therapy Debated ... A press conference at the annual meeting of the American Association for the Advancement of Science in Washington, D.C., last month turned into an impromptu debate on the ethical and policy implications of human gene therapy. ... The protagonists were biomedical ethicist LeRoy Walters of Georgetown University, and attorney Andrew Kimbrell of the Foundation on Economic Trends, an activist group that has filed many lawsuits relating to biotechnology. ...

STU BORMAN

1991-03-04T23:59:59.000Z

30

Fusion genes in breast cancer  

E-Print Network [OSTI]

Fusion genes in breast cancer Elizabeth M. Batty Clare College, University of Cambridge A dissertation submitted to the University of Cambridge in candidature for the degree of Doctor of Philosophy November 2010 ii... is the outcome of work done in collaboration except where specifically indicated in the text. It has not been submitted whole or in part for any other qualification at any other University. iii Summary Fusion genes in breast cancer Elizabeth Batty...

Batty, Elizabeth

2012-02-07T23:59:59.000Z

31

The need for a human gene index  

Science Journals Connector (OSTI)

......need for a human gene index. | Editorial | Abstracting...NEED FOR A HUMAN GENE INDEX Much noise has been made...the year 2000 about the completion of a "draft" of the...changes in assembly and completion of the draft genome...need for a human gene index Towards a true gene index......

C. Victor Jongeneel

2000-12-01T23:59:59.000Z

32

Mining Virulence Genes Using Metagenomics  

E-Print Network [OSTI]

When a bacterial genome is compared to the metagenome of an environment it inhabits, most genes recruit at high sequence identity. In free-living bacteria (for instance marine bacteria compared against the ocean metagenome) certain genomic regions are totally absent in recruitment plots, representing therefore genes unique to individual bacterial isolates. We show that these Metagenomic Islands (MIs) are also visible in bacteria living in human hosts when their genomes are compared to sequences from the human microbiome, despite the compartmentalized structure of human-related environments such as the gut. From an applied point of view, MIs of human pathogens (e.g. those identified in enterohaemorragic Escherichia coli against the gut metagenome or in pathogenic Neisseria meningitidis against the oral metagenome) include virulence genes that appear to be absent in related strains or species present in the microbiome of healthy individuals. We propose that this strategy (i.e. recruitment analysis of pathogenic bacteria against the metagenome of healthy subjects) can be used to detect pathogenicity regions in species where the genes involved in virulence are poorly characterized. Using this approach, we detect well-known pathogenicity islands and identify new potential virulence genes in several human pathogens.

Pedro Belda-ferre; Ral Cabrera-rubio; Andrs Moya; Alex Mira

2011-01-01T23:59:59.000Z

33

Gene encoding plant asparagine synthetase  

DOE Patents [OSTI]

The identification and cloning of the gene(s) for plant asparagine synthetase (AS), an important enzyme involved in the formation of asparagine, a major nitrogen transport compound of higher plants is described. Expression vectors constructed with the AS coding sequence may be utilized to produce plant AS; to engineer herbicide resistant plants, salt/drought tolerant plants or pathogen resistant plants; as a dominant selectable marker; or to select for novel herbicides or compounds useful as agents that synchronize plant cells in culture. The promoter for plant AS, which directs high levels of gene expression and is induced in an organ specific manner and by darkness, is also described. The AS promoter may be used to direct the expression of heterologous coding sequences in appropriate hosts.

Coruzzi, Gloria M. (New York, NY); Tsai, Fong-Ying (New York, NY)

1993-10-26T23:59:59.000Z

34

Using co-expression to redefine functional gene sets for gene set enrichment analysis  

E-Print Network [OSTI]

Manually curated gene sets related to a biological function often contain genes that are not tightly co-regulated transcriptionally. which obscures the evidence of coordinated differential expression of these gene sets in ...

Kodysh, Yuliya

2007-01-01T23:59:59.000Z

35

Gene 240 (1999) 4555 www.elsevier.com/locate/gene  

E-Print Network [OSTI]

gene of E. coli, which encodes an essentialtide(s); ORF, open reading frame; PAC, P1 artificial; Protein expression from ARD-1 cDNA in E. coli resultsSDS, sodium dodecyl sulfate; snRNP, small nuclear Abstract ARD-1 is an endoribonuclease identified initially as the product of a human cDNA that complements

Trinkle-Mulcahy, Laura

36

Antibody library project could unlock mysteries of human gene...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mysteries of human gene function Antibody library project could unlock mysteries of human gene function By looking at antibodies, researchers can identify where, in a cell, genes...

37

Regulation of Alpha-Amylase Gene Expression  

Science Journals Connector (OSTI)

The aim of our studies is to elucidate in molecular detail the principles underlying the tissue specific expression of eucaryotic genes. It is hoped that by understanding how a particular gene becomes activated i...

H. C. Hurst; O. Hagenbchle; U. Schibler

1986-01-01T23:59:59.000Z

38

Gene synthesis by circular assembly amplification  

E-Print Network [OSTI]

Gene synthesis by circular assembly amplification Duhee Bang & George M Church Here we report the development of a gene-synthesis technology, circular assembly amplification. In this approach, we first error-rich products, thereby substantially improving gene-synthesis quality. We used this method

Church, George M.

39

Genes, Themes and Microarrays Using Information Retrieval for LargeScale Gene Analysis  

E-Print Network [OSTI]

research effort. 4. Due to the interrelated nature of biological processes, genes may have more than

Shatkay, Hagit

40

Magnetotactic Bacteria: A Study of Mam Genes and Metabolism  

E-Print Network [OSTI]

, lacks several hemerythrin genes that might represent a gene island that harbors genes that encode hemerythrin island causes the non-magnetic phenotype or if deletion of magnetosome genes is involved as well

Walker, Lawrence R.

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Method for determining gene knockouts  

DOE Patents [OSTI]

A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.

Maranas, Costa D; Burgard, Anthony R; Pharkya, Priti

2013-06-04T23:59:59.000Z

42

Gene Therapy for Color Blindness  

Science Journals Connector (OSTI)

...injection of a recombinant, replication-defective adeno-associated virus (AAV) (Figure 1). Before injection, blue-green and red-violet colors were invisible to the monkeys, as determined by a computer-based test of color vision. Five months after injection, the monkeys were found to have trichromatic vision... The subretinal introduction of a gene encoding an opsin into two color-blind monkeys lacking that opsin resulted in the acquisition of trichromatic vision.

Bennett J.

2009-12-17T23:59:59.000Z

43

Gene Therapy and Biological Pacing  

Science Journals Connector (OSTI)

...stem-cell vehicles to deliver ion-channel genes to the heart, and with the injection of biological pacemakers derived from embryonic stem cells (Figure 1), the report by Hu et al. is only the second in large animals to describe a biological pacemaker that induces heart rates and autonomic function that... TBX18 is a transcription factor critical to the specification of the sinoatrial node during normal development. A recent pig model of heart block suggests that the injection of a vector carrying TBX18 induces physiologically relevant pacemaker activity for 11 days.

Rosen M.R.

2014-09-18T23:59:59.000Z

44

Cross-Ontological Analytics: Combining Associative and Hierarchical Relations in the Gene Ontologies to Assess Gene Product Similarity  

SciTech Connect (OSTI)

Gene and gene product similarity is a fundamental diagnostic measure in analyzing biological data and constructing predictive models for functional genomics. With the rising influence of the gene ontologies, two complementary approaches have emerged where the similarity between two genes/gene products is obtained by comparing gene ontology (GO) annotations associated with the gene/gene products. One approach captures GO-based similarity in terms of hierarchical relations within each gene ontology. The other approach identifies GO-based similarity in terms of associative relations across the three gene ontologies. We propose a novel methodology where the two approaches can be merged with ensuing benefits in coverage and accuracy.

Posse, Christian; Sanfilippo, Antonio P.; Gopalan, Banu; Riensche, Roderick M.; Beagley, Nathaniel; Baddeley, Bob L.

2006-05-28T23:59:59.000Z

45

A fruit quality gene map of Prunus  

E-Print Network [OSTI]

Central Open Access A fruit quality gene map of PrunusAbstract Background: Prunus fruit development, growth,and maintaining stone fruit quality from production and

Ogundiwin, Ebenezer A; Peace, Cameron P; Gradziel, Thomas M; Parfitt, Dan E; Bliss, Fredrick A; Crisosto, Carlos H

2009-01-01T23:59:59.000Z

46

Imaging Gene Expression | The Ames Laboratory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Gene Expression FWPProject Description: Project Leader(s): Marit Nilsen-Hamilton Principal Investigators: George Kraus We are developing apatmers to use as cellular...

47

LSUHSC NEW ORLEANS GENE THERAPY PUBLICATIONS  

E-Print Network [OSTI]

delivery of galactocerebrosidase tagged with the HIV Tat protein transduction domain. Journal-Negative Rev Gene Into Human CD34(+) Hematopoietic Progenitor Cells Potently Inhibits HIV-1 Replication

48

GeneFarm, structural and functional annotation of Arabidopsis gene and protein families by a network  

E-Print Network [OSTI]

, and more secure planning and design of experiments. The purpose of the GeneFarmprojectis to obtain

Gent, Universiteit

49

Gene-set Cohesion Analysis Tool (GCAT): A literature based web tool for calculating functional cohesiveness of gene groups  

Science Journals Connector (OSTI)

Numerous algorithms exist for producing gene sets from high-throughput genomic and proteomic technologies. However, analysis of the functional significance of these groups of genes or proteins remains a big challenge. We developed a Web based system ... Keywords: interferon, gene set cohesion analysis tool, functional cohesiveness, gene groups, genomics, proteomics, latent semantic indexing, gene ontology, embryonic fibroblasts, literature based Web tool, gene-gene literature similarities, microarray data analysis

Lijing Xu; R. Homayouni; N. A. Furlotte; K. E. Heinrich; E. O. George; M. W. Berry

2009-11-01T23:59:59.000Z

50

Gene therapy in alcoholic rats  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

70 70 Sept. 9, 2001 Gene Therapy Reduces Drinking in "Alcoholic" Rats UPTON, NY - Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have shown that increasing the level of a brain protein important for transmitting pleasure signals can turn rats that prefer alcohol into light drinkers, and those with no preference into near teetotalers. The findings, published in the first September 2001 issue of the Journal of Neurochemistry (Vol. 78, No. 5), may have implications for the prevention and treatment of alcoholism in humans. "This is a preliminary study, but when you see a rat that chooses to drink 80 to 90 percent of its daily fluid as alcohol, and then three days later it's down to 20 percent, that's a dramatic drop in alcohol intake - a very clear change in behavior," said Panayotis Thanos, the lead researcher. "This gives us great hope that we can refine this treatment for future clinical use."

51

Assignment of Orthologous Genes via Genome Rearrangement  

E-Print Network [OSTI]

Assignment of Orthologous Genes via Genome Rearrangement Xin Chen, Jie Zheng, Zheng Fu, Peng Nan of genomes is a fundamental and challenging problem in comparative genomics. Existing methods that assign sequence similarity and evolutionary events at a genome level, where orthologous genes are assumed

Lonardi, Stefano

52

Gene prediction by multiple spliced alignment  

Science Journals Connector (OSTI)

With recent advances in sequencing technologies, a huge amount of DNA sequences become available year after year. In order to obtain useful information on these sequences, we need to process them in search of biologically meaningful regions. The genes ... Keywords: comparative genomics, gene prediction, multiple spliced alignment

Rodrigo Mitsuo Kishi; Ronaldo Fiorilo dos Santos; Said Sadique Adi

2011-08-01T23:59:59.000Z

53

Targets and indicators for gene level biodiversity  

E-Print Network [OSTI]

Targets and indicators for gene level biodiversity Resilience and future adaptation in forests, inland waters and marine environments depend on genetic variation Welcome to the Side-event on Lunch.weibull@naturvardsverket.se BaltGene­BalticSeaGeneticBiodiversity www.tmbl.gu.se:16080/baltgene GeneticMonitoring http

54

Gene coding for the E1 endoglucanase  

DOE Patents [OSTI]

The gene encoding Acidothermus cellulolyticus E1 endoglucanase is cloned and expressed in heterologous microorganisms. A new modified E1 endoglucanase enzyme is produced along with variants of the gene and enzyme. The E1 endoglucanase is useful for hydrolyzing cellulose to sugars for simultaneous or later fermentation into alcohol. 6 figs.

Thomas, S.R.; Laymon, R.A.; Himmel, M.E.

1996-07-16T23:59:59.000Z

55

Association and Interactions between DNA Repair Gene Polymorphisms and Adult Glioma  

Science Journals Connector (OSTI)

...analyzing gene-gene and gene-environment interactions. First, using...professions were also pilots and engineers. Of the 373 cases, 214...Gene-Gene and Gene-Environment Interactions Analysis Cumulative...for gene-gene and gene-environment interactions on glioma risk...

Yanhong Liu; Michael E. Scheurer; Randa El-Zein; Yumei Cao; Kim-Anh Do; Mark Gilbert; Kenneth D. Aldape; Qingyi Wei; Carol Etzel; and Melissa L. Bondy

2009-01-01T23:59:59.000Z

56

Tissue-Specific Gene Delivery via Nanoparticle Coating  

E-Print Network [OSTI]

The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

Harris, Todd J.

57

Comparative gene identification in mammalian, fly, and fungal genomes  

E-Print Network [OSTI]

An important step in genome interpretation is the accurate identification of protein-coding genes. One approach to gene identification is comparative analysis of the genomes of several related species, to find genes that ...

Lin, Michael F. (Michael Fong-Jay)

2006-01-01T23:59:59.000Z

58

Computationally Optimised DNA Assembly of synthetic genes  

Science Journals Connector (OSTI)

Gene synthesis is hampered by two obstacles: improper assembly of oligonucleotides; oligonucleotide defects incurred during chemical synthesis. To overcome the first problem, we describe the employment of a Computationally Optimised DNA Assembly (CODA) algorithm that uses the degeneracy of the genetic code to design overlapping oligonucleotides with thermodynamic properties for self-assembly into a single, linear, DNA product. To address the second problem, we describe a hierarchical assembly strategy that reduces the incorporation of defective oligonucleotides into full-length gene constructs. The CODA algorithm and these biological methods enable fast, simple and reliable assemblies of sequence-correct full-length genes.

Liza S.Z. Larsen; Christopher D. Wassman; G. Wesley Hatfield; Richard H. Lathrop

2008-01-01T23:59:59.000Z

59

Heat induces gene amplification in cancer cells  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer This study discovered that heat exposure (hyperthermia) results in gene amplification in cancer cells. Black-Right-Pointing-Pointer Hyperthermia induces DNA double strand breaks. Black-Right-Pointing-Pointer DNA double strand breaks are considered to be required for the initiation of gene amplification. Black-Right-Pointing-Pointer The underlying mechanism of heat-induced gene amplification is generation of DNA double strand breaks. -- Abstract: Background: Hyperthermia plays an important role in cancer therapy. However, as with radiation, it can cause DNA damage and therefore genetic instability. We studied whether hyperthermia can induce gene amplification in cancer cells and explored potential underlying molecular mechanisms. Materials and methods: (1) Hyperthermia: HCT116 colon cancer cells received water-submerged heating treatment at 42 or 44 Degree-Sign C for 30 min; (2) gene amplification assay using N-(phosphoacetyl)-L-aspartate (PALA) selection of cabamyl-P-synthetase, aspartate transcarbarmylase, dihydro-orotase (cad) gene amplified cells; (3) southern blotting for confirmation of increased cad gene copies in PALA-resistant cells; (4) {gamma}H2AX immunostaining to detect {gamma}H2AX foci as an indication for DNA double strand breaks. Results: (1) Heat exposure at 42 or 44 Degree-Sign C for 30 min induces gene amplification. The frequency of cad gene amplification increased by 2.8 and 6.5 folds respectively; (2) heat exposure at both 42 and 44 Degree-Sign C for 30 min induces DNA double strand breaks in HCT116 cells as shown by {gamma}H2AX immunostaining. Conclusion: This study shows that heat exposure can induce gene amplification in cancer cells, likely through the generation of DNA double strand breaks, which are believed to be required for the initiation of gene amplification. This process may be promoted by heat when cellular proteins that are responsible for checkpoints, DNA replication, DNA repair and telomere functions are denatured. To our knowledge, this is the first study to provide direct evidence of hyperthermia induced gene amplification.

Yan, Bin, E-mail: yanbin@mercyhealth.com [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States) [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States); Mercy Cancer Center, Mercy Medical Center-North Iowa, Mason City, IA 50401 (United States); Ouyang, Ruoyun [Department of Respiratory Medicine, The Second Xiangya Hospital, Xinagya School of Medicine, Central South University, Changsha 410011 (China)] [Department of Respiratory Medicine, The Second Xiangya Hospital, Xinagya School of Medicine, Central South University, Changsha 410011 (China); Huang, Chenghui [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States) [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States); Department of Oncology, The Third Xiangya Hospital, Xinagya School of Medicine, Central South University, Changsha 410013 (China); Liu, Franklin [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States)] [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States); Neill, Daniel [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States)] [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States); Li, Chuanyuan [Dermatology, Duke University Medical Center, Durham, NC 27710 (United States)] [Dermatology, Duke University Medical Center, Durham, NC 27710 (United States); Dewhirst, Mark [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States)] [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States)

2012-10-26T23:59:59.000Z

60

Finding a gene in a haystack  

Science Journals Connector (OSTI)

... the size of sample, double or triple samples can be processed simultaneously. Packaged under cleanroom conditions, Gene Frame II can be autoclaved and sterilized by ultraviolet irradiation. The adhesives ...

1997-02-27T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Horizontal gene transfer in Bacteroides fragilis  

E-Print Network [OSTI]

Horizontal gene transfer (HGT) is one of the man driving forces of evolution in prokaryotes, and can also promote within-strain variation of bacterial species. The genomes of three previously sequenced Bacteroides fragilis ...

Jobling, Kelly Louise

2014-11-27T23:59:59.000Z

62

Validation of Gene Therapy Manufacturing Processes  

Science Journals Connector (OSTI)

Specific issues of concern in the validation of gene therapy viral vector manufacturing processes include quality of raw materials, safety testing of cell and viral banks, production and purification of the ve...

Dominick Vacante; Gail Sofer; Stephen Morris

2002-01-01T23:59:59.000Z

63

Post transcriptional regulation of chloroplast gene expression by nuclear encoded gene products  

SciTech Connect (OSTI)

Many individual chloroplast genes require the products of a collection of nuclear genes for their successful expression. These nuclear gene products apparently work with great specificity, each committed to the expression of a single chloroplast gene. We have chosen as a model nuclear mutants of Chlamydomonas affected in different stages in the expression of the chloroplast encoded Photosystem II polypeptide, D2. We have made the progress in understanding how nuclear gene products affect the translation of the D2 encoding MRNA. Two nuclear genes are required for this process which have been mapped genetically. In contrast to other examples of nuclear control of translation in the chloroplast, these nuclear gene products appear to be required either for specific stages in translation elongation or for the post-translational stabilization of the nascent D2 protein. Pseudoreversion analysis has led us to a locus which may be directly involved in D2 expression. We have made considerable progress in pursuing the molecular basis of psbd MRNA stabilization. psbD 5' UTR specific transcripts have been synthesized in vitro and used in gel mobility shift assays. UV-crosslinking studies are underway to identify the transacting factors which bind to these sequences. The continued examination of these mutants will help us to understand how nuclear gene products work in this specific case of chloroplast gene expression, and will elucidate how two distinct genomes can interact generally.

Kuchka, M.R.

1992-01-01T23:59:59.000Z

64

GenePRIMP: A GENE PRediction IMprovement Pipeline for Prokaryotic genomes  

E-Print Network [OSTI]

PRediction IMprovement Pipeline for Amrita Pati 1 , NataliaGene Prediction IMprovement Pipeline, http://geneprimp.jgi-based post-processing pipeline that identifies erroneously

Pati, Amrita

2012-01-01T23:59:59.000Z

65

Characterization and expression of histone deacetylase 1 (athd1) in Arabidopsis thaliana  

E-Print Network [OSTI]

...........................................................................................................................95 ix LIST OF FIGURES Page Figure 2.1 The construct of AtHD1-GFP chimeric gene ........................... 19 Figure 2.2 Localization of AtHD1-GFP fusion protein in onion cells... (Kankel et al., 2003). Second, DRM1 5 (Domain-Rearranged Methyltransferase 1) and DRM2, which are similar to the mammalian DNMT3 family of methyltransferases, were identified as de novo methyltransferases in genome defense (Cao and Jacobsen, 2002a...

Fong, Man Kim

2005-08-29T23:59:59.000Z

66

Reverse Engineering and Analysis of Genome-Wide Gene Regulatory Networks from Gene Expression Profiles Using High-Performance Computing  

Science Journals Connector (OSTI)

Regulation of gene expression is a carefully regulated phenomenon in the cell. "Reverse-engineering algorithms try to reconstruct the regulatory interactions among genes from genome-scale measurements of gene expression profiles (microarrays). ... Keywords: Reverse engineering, gene regulatory network, clustering algorithm, parallel computing.

Vincenzo Belcastro; Francesco Gregoretti; Velia Siciliano; Michele Santoro; Giovanni D'Angelo; Gennaro Oliva; Diego di Bernardo

2012-05-01T23:59:59.000Z

67

Identifying subtle interrelated changes in functional gene categories using continuous measures of gene expression  

Science Journals Connector (OSTI)

......lists of genes with EASE. Genome Biol. 4 R70 Liu, G., Loraine, A.E., Shigeta, R., Cline, M., Cheng, J., Valmeekam...of genes with EASE. Genome Biol., 4, R70. Liu,G., Loraine,A.E., Shigeta,R., Cline,M., Cheng,J., Valmeekam......

Yoram Ben-Shaul; Hagai Bergman; Hermona Soreq

2005-04-01T23:59:59.000Z

68

Gene Expression Analyses and Association Studies of Wood Development Genes in Loblolly Pine (Pinus taeda L.)  

E-Print Network [OSTI]

for the selected genes of this project. 4 Genetic variation in pines has been studied extensively because of a high level of variation in natural populations (Hamrick and Godt 1996; Ledig 1998). Gene expression analysis is a valuable tool for generating...

Palle, Sreenath Reddy

2011-10-21T23:59:59.000Z

69

Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma  

DOE Patents [OSTI]

A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other epithelial cancers in a patient by delivering products that modulate Id-1 gene expression. When expressed, Id-1 gene is a prognostic indicator that cancer cells are invasive and metastatic.

Desprez, Pierre-Yves; Campisi, Judith

2014-08-19T23:59:59.000Z

70

(for Gene Recognition Analysis Internet Link),  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

5 6/1/2011 5 6/1/2011 6.6 Speeding Up the Process of Gene Discovery The human genome contains information that could be used to prevent birth defects and treat or cure devastating diseases, but it is written in a language that scientists are only beginning to understand. To help decipher the code, Ed Uberbacher and colleagues at Oak Ridge National Laboratory combined cutting- edge computer technology with their knowledge of human biology to develop GRAIL (for Gene Recognition Analysis Internet Link), a "thinking" computer program that imitates the human learning process as it searches for genetic meaning. GRAIL and successor software programs can rapidly identify key instructions in genes from within vast stretches of DNA that appear to be meaningless-a critical contribution to the

71

Retroviral vectors for human gene delivery  

Science Journals Connector (OSTI)

The potential for gene therapy to cure a wide range of diseases has lead to high expectations and a great increase in research efforts in this area. At present, viral vectors are the most efficient means of delivering a corrective gene into human cells. While a number of different viral vectors are under development, retroviral vectors are currently the most common type used in clinical trials today. However, the production of retroviral vectors for gene therapy applications faces a number of challenges. Of primary concern is the low titre of vector stocks produced by packaging cells in culture and the inherent instability of retroviral vector activity. The problems facing large-scale retroviral vector production are outlined in this review and the research efforts by a number of groups who have attempted to optimise production methods are presented.

Sally McTaggart; Mohamed Al-Rubeai

2002-01-01T23:59:59.000Z

72

Regulation of methane genes and genome expression  

SciTech Connect (OSTI)

At the start of this project, it was known that methanogens were Archaeabacteria (now Archaea) and were therefore predicted to have gene expression and regulatory systems different from Bacteria, but few of the molecular biology details were established. The goals were then to establish the structures and organizations of genes in methanogens, and to develop the genetic technologies needed to investigate and dissect methanogen gene expression and regulation in vivo. By cloning and sequencing, we established the gene and operon structures of all of the methane genes that encode the enzymes that catalyze methane biosynthesis from carbon dioxide and hydrogen. This work identified unique sequences in the methane gene that we designated mcrA, that encodes the largest subunit of methyl-coenzyme M reductase, that could be used to identify methanogen DNA and establish methanogen phylogenetic relationships. McrA sequences are now the accepted standard and used extensively as hybridization probes to identify and quantify methanogens in environmental research. With the methane genes in hand, we used northern blot and then later whole-genome microarray hybridization analyses to establish how growth phase and substrate availability regulated methane gene expression in Methanobacterium thermautotrophicus ?H (now Methanothermobacter thermautotrophicus). Isoenzymes or pairs of functionally equivalent enzymes catalyze several steps in the hydrogen-dependent reduction of carbon dioxide to methane. We established that hydrogen availability determine which of these pairs of methane genes is expressed and therefore which of the alternative enzymes is employed to catalyze methane biosynthesis under different environmental conditions. As were unable to establish a reliable genetic system for M. thermautotrophicus, we developed in vitro transcription as an alternative system to investigate methanogen gene expression and regulation. This led to the discovery that an archaeal protein, designated TFE, that had sequences in common with the eukaryotic general transcription factor TFIIE, stimulated archaeal transcription initiation and that the archaeal TATA-box binding protein (TBP) remained attached to the promoter region whereas the transcription factor TFB dissociated from the template DNA following initiation. DNA sequences that directed the localized assembly of archaeal histones into archaeal nucleosomes were identified, and we established that transcription by an archaeal RNA polymerase was slowed but not blocked by archaeal nucleosomes. We developed a new protocol to purify archaeal RNA polymerases and with this enzyme and additional improvements to the in vitro transcription system, we established the template requirements for archaeal transcription termination, investigated the activities of proteins predicted to be methane gene regulators, and established how TrpY, a novel archaeal regulator of expression of the tryptophan biosynthetic operon functions in M. thermautotrophicus. This also resulted in the discovery that almost all M. thermautotrophicus mutants isolated as spontaneously resistant to 5-methyl tryptophan (5MTR) had mutations in trpY and were therefore 5MTR through de-repressed trp operon expression. This established a very simple, practical procedure to determine and quantify the DNA sequence changes that result from exposure of this Archaeon to any experimental mutagenesis protocol. Following the discovery that the Thermococcus kodakaraensis was amenable to genetic manipulation, we established this technology at OSU and subsequently added plasmid expression, a reporter system and additional genetic selections to the T. kodakaraensis genetic toolbox. We established that transcription and translation are coupled in this Archaeon, and by combining in vitro transcription and in vivo genetics, we documented that both TFB1 and TFB2 support transcription initiation in T. kodakaraensis. We quantified the roles of ribosome binding sequences and alternative initiation codons in translation initiation, established that polarity e

John N. Reeve

2009-09-09T23:59:59.000Z

73

Basidiomycete Mating Type Genes and Pheromone Signaling  

Science Journals Connector (OSTI)

...behavior and only a slight reduction of aerial hyphal formation were seen in the homokaryotic...and gpc genes, reduces the growth of aerial hyphae and, when homoallelic in a dikaryon...S. Fox, V. Grinberg, J. Fu, M. Fukushima, B. J. Haas, J. C. Huang, G. Janbon...

Marjatta Raudaskoski; Erika Kothe

2010-02-26T23:59:59.000Z

74

Expression of the MHC Class III Genes  

Science Journals Connector (OSTI)

...biosynthesis of the MHC class III products; for example...C2-producing cells is greater in freshly isolated macrophages...to expression of the class III MHC gene products...biosynthesis of the MHC class III products; for example...C2-producing cells is greater in freshly isolated macrophages...

1984-01-01T23:59:59.000Z

75

Inferring differentiation pathways from gene expression  

Science Journals Connector (OSTI)

......as finding the pdf p t [x] that...multivariate Gaussian pdf is defined (Cover...From genomics to chemical genomics: new...Som toolbox for matlab. In: Technical...Supplementary Data - pdf file Inferring...underlying molecular processes. In previous...physiology Computer Simulation Gene Expression......

Ivan G. Costa; Stefan Roepcke; Christoph Hafemeister; Alexander Schliep

2008-07-01T23:59:59.000Z

76

Should there be property rights in genes?  

Science Journals Connector (OSTI)

...whether large or small, can be `owned' in the same way as cars and houses, and so be subject to being bought and sold? Society...which produce them would be to prevent the transmission of defective genes to subsequent generations. Some would prohibit all such...

1997-01-01T23:59:59.000Z

77

Disentangling Mental Disorders : from Genes to Circuits  

E-Print Network [OSTI]

Summer Program 2014 Disentangling Mental Disorders : from Genes to Circuits RIKEN Brain Science Application : http://www.brain.riken.jp/en/summer/ Inquiries : info.summer@brain.riken.jp RIKEN Brain Science July 15-July 22, 2014 Summer Program 2014 Summer Program 2014 RIKEN Brain Science InstituteRIKEN Brain

Kazama, Hokto

78

E-Print Network 3.0 - acid metabolism-related genes Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

attempt... Genes in the environment Genes and Ecosystems Dr Eshwar Mahenthiralingam (Esh) Cardiff University... 12;Genes in the environment Ecosystems (food, medicine, soil...

79

E-Print Network 3.0 - atctl2 gene enhances Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Genes in the environment Genes and Ecosystems Dr Eshwar Mahenthiralingam (Esh) Cardiff University... 12;Genes in the environment Ecosystems (food, medicine, soil...

80

E-Print Network 3.0 - antifreeze protein gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and nuclear gene sequences Summary: ribosomal protein intron 1), and combined dataset containing the mtDNA and nuclear genes resulted... complete gene sequences from...

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

E-Print Network 3.0 - atherosclerosis gene expression Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Gene Sequences In Drosophila melanogaster... , USA We performed a systematic BLAST analysis of 929 human disease gene entries associated... disease genes (77% of disease...

82

E-Print Network 3.0 - animal gene families Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

a curated database of phylogenetic trees of animal gene families... Fam: a curated database of phylogenetic trees of animal gene families 12,400 animal gene ... Source:...

83

E-Print Network 3.0 - akt-mediated gene repression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

rapid reactivation of transcription, a phenomenon known... - scription results in gene looping. After repression, genes can remain looped through interac- tions... that gene...

84

Regulation of HIV-1 gene expression  

SciTech Connect (OSTI)

The quantity and quality of HIV-1 gene expression is temporally controlled by a cascade of sequential regulatory interactions. basal HIV-1 transcription is determined by interaction of cellular regulatory proteins with specific DNA target sequences within the HIV-1 long-terminal repeat. The most notable of these protein: DNA interactions involves NF-{aleph}B, a transcription factor that plays a pivotal role in the activation of genes important for cellular responses to infection and inflammation. A second level of control involves the virally encoded Tat trans-activator. Tat, in combination with as yet unidentified cellular proteins, activates HIV-1 gene expression through a specific interaction with the viral TAR RNA stem-loop target sequence. A final level of regulation is mediated by the viral Rev protein. Rev acts posttranscriptionally to induce the expression of HIV-1 structural proteins and thereby commits HIV-1 to the late, cytopathic phase of the viral replication cycle. Rev activity appears to require a critical, threshold level of Rev protein expression, thus preventing entry into this late phase in cells that are unable to support efficient HIV-1 gene expression. In total, this cascade of regulatory levels allow the HIV-1 provirus to respond appropriately to the intracellular milieu present in each infected cell. In activated cells, the combination of Tat and Rev can stimulate a very high level of viral gene expression and replication. In quiescent or resting cells, in contrast, these same regulatory proteins are predicted to maintain the HIV-1 provirus in a latent or nonproductive state.

Cullen, B.R. (Duke Univ., Durham, NC (United States))

1991-07-01T23:59:59.000Z

85

Abnormal Gene Expression of Four Genes in Cells from Family Members of  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Abnormal Gene Expression of Four Genes in Cells from Family Members of Abnormal Gene Expression of Four Genes in Cells from Family Members of Hereditary-type Retinoblastoma Patients relative to Normal Individuals Chin-Yu Wang, 1 Yuanlin Peng, 1 Zhonghui Yang, 2 Chuan-Yuan Li, 2 Hatsumi Nagasawa, 1 Markus M. Fitzek, 3 John B. Little, 4 Joel S. Bedford, 1 and Eric Y. Chuang 5 1 Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado; 2 Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina; 3 Department of Radiation Oncology, Tufts-New England Medical Center; 4 Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts; and 5 Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan

86

E-Print Network 3.0 - allelic based gene-gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

identify many common alleles of major effect... to that in humans7,8 , the resulting SNP density of one SNP per 500 base pairs is considerably higher than... number of genes (Fig....

87

Reduced expression of Autographa californica nucleopolyhedrovirus ORF34, an essential gene, enhances heterologous gene expression  

SciTech Connect (OSTI)

Autographa californica multiple nucleopolyhedrovirus ORF34 is part of a transcriptional unit that includes ORF32, encoding a viral fibroblast growth factor (FGF) and ORF33. We identified ORF34 as a candidate for deletion to improve protein expression in the baculovirus expression system based on enhanced reporter gene expression in an RNAi screen of virus genes. However, ORF34 was shown to be an essential gene. To explore ORF34 function, deletion (KO34) and rescue bacmids were constructed and characterized. Infection did not spread from primary KO34 transfected cells and supernatants from KO34 transfected cells could not infect fresh Sf21 cells whereas the supernatant from the rescue bacmids transfection could recover the infection. In addition, budded viruses were not observed in KO34 transfected cells by electron microscopy, nor were viral proteins detected from the transfection supernatants by western blots. These demonstrate that ORF34 is an essential gene with a possible role in infectious virus production.

Salem, Tamer Z. [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States) [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States); Department of Microbial Molecular Biology, AGERI, Agricultural Research Center, Giza 12619 (Egypt); Division of Biomedical Sciences, Zewail University, Zewail City of Science and Technology, Giza 12588 (Egypt); Zhang, Fengrui [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States)] [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States); Thiem, Suzanne M., E-mail: smthiem@msu.edu [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States); Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824 (United States)

2013-01-20T23:59:59.000Z

88

Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering  

E-Print Network [OSTI]

Recent advances in tissue engineering, combining an extracellular matrix (ECM)-like vehicle with therapeutic molecules, cells and/or genes has yielded promising results for brain injury repair. The purpose of this thesis ...

Bolliet, Catherine

2007-01-01T23:59:59.000Z

89

Nonsyntenic Genes Drive Highly Dynamic Complementation of Gene Expression in Maize Hybrids  

Science Journals Connector (OSTI)

...Authors ( www.plantcell.org ) is: Frank Hochholdinger ( hochholdinger@uni-bonn.de ). [W] Online version contains Web-only data. This study analyzes how transcriptome diversity between two maize inbred lines affects gene expression patterns...

Anja Paschold; Nick B. Larson; Caroline Marcon; James C. Schnable; Cheng-Ting Yeh; Christa Lanz; Dan Nettleton; Hans-Peter Piepho; Patrick S. Schnable; Frank Hochholdinger

2014-10-14T23:59:59.000Z

90

Mutational Analysis of the Wilms' Tumor (WTI) Gene  

Science Journals Connector (OSTI)

Mutations of the Wilms tumor (WT1) gene have been shown to underlie a proportion of cases of Wilms tumor, an embryonal kidney cancer occurring mainly in childhood. The WTl gene comprtses ten exons spanning a...

Linda King-Underwood; Kathy Pritchard-Jones

1996-01-01T23:59:59.000Z

91

Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes  

E-Print Network [OSTI]

Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes Sarath. Although it is known that eukaryotic transcriptional regulation is complex and requires an intricate-order organization of genes across and within chromosomes that is constrained by transcriptional regulation

Babu, M. Madan

92

Regulation of Gene Expression by Synthetic DNA-Binding Ligands  

E-Print Network [OSTI]

Regulation of Gene Expression by Synthetic DNA-Binding Ligands Peter B. Dervan ( ) · Adam T. Poulin

Dervan, Peter B.

93

Evidence Combination in Hidden Markov Models for Gene Bronislava Brejova  

E-Print Network [OSTI]

the human and fruit fly genomes. The use of sequence evolutionary conservation as a source of evidence introduces new techniques for finding genes in genomic sequences. Genes are regions of a genome encoding proteins of an organism. Identification of genes in a genome is an important step in the annotation process

Brejova, Brona

94

2005 Nature Publishing Group Photosynthesis genes in marine viruses yield  

E-Print Network [OSTI]

© 2005 Nature Publishing Group Photosynthesis genes in marine viruses yield proteins during host­6 probably influences the genetic and functional diversity of both. For example, photosynthesis genes period. We also show that the expression of host photosynthesis genes declines over the course

Church, George M.

95

An Adaptive GAPSO Approach with Gene Clustering to Infer S-system Models of Gene Regulatory Networks  

Science Journals Connector (OSTI)

......In addition, we plan to develop advanced...analysis of gene regulatory networks. Nat...simulation of genetic regulatory systems: a literature review. J. Comput. Biol...Inference of Gene Regulatory Networks Using S-system......

Wei-Po Lee; Yu-Ting Hsiao

2011-09-01T23:59:59.000Z

96

Identification of DNA marker for root-knot nematode resistance gene and characterization of disease resistance gene candidates in cotton  

E-Print Network [OSTI]

of root-knot nematode resistance (RNR) in Auburn 623 - one of the most desirable sources for RNR in Upland cottons, identification of DNA markers for the RNR genes and characterization of disease resistance gene candidates in cotton. Genetic analysis...

He, Limei

2000-01-01T23:59:59.000Z

97

Human interactome resource and gene set linkage analysis for the functional interpretation of biologically meaningful gene sets  

Science Journals Connector (OSTI)

......interactome resource and gene set linkage analysis for the functional interpretation of biologically meaningful gene sets Xi Zhou Pengcheng Chen Qiang Wei Xueling Shen Xin Chen * *To whom correspondence should be addressed. Department of Bioinformatics, College......

Xi Zhou; Pengcheng Chen; Qiang Wei; Xueling Shen; Xin Chen

2013-08-15T23:59:59.000Z

98

E-Print Network 3.0 - arctica gene cloning Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: 19 GENE2147X KIAA0282 KIAA0282 protein GENE2906X Homo sapiens cDNA FLJ13700 fis, clone PLACE2000216... 2DTL protein GENE3683X LAD1 ladinin 1 GENE6843X Homo sapiens...

99

HyDRA: Gene Prioritization via Hybrid Distance-Score Rank Aggregation  

Science Journals Connector (OSTI)

......computational techniques for inferring disease genes through a set of training genes and carefully chosen similarity criteria. Test genes are scored based on their average similarity to the training set, and the rankings of genes under various similarity criteria......

Minji Kim; Farzad Farnoud; Olgica Milenkovic

2014-11-01T23:59:59.000Z

100

E-Print Network 3.0 - anoxia-responsive gene expression Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

. . . . . . . . . . . . . . . . . . . . . 266 3. Anoxia-responsive gene expression in turtle organs... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

The impact of long-distance horizontal gene transfer on prokaryotic genome size  

E-Print Network [OSTI]

Horizontal gene transfer (HGT) is one of the most dominant forces molding prokaryotic gene repertoires. These repertoires can be as small as ?200 genes in intracellular organisms or as large as ?9,000 genes in large, ...

Cordero Sanchez, Otto Xavier

102

Characterization of a unique embedded gene  

E-Print Network [OSTI]

and RzlW38am alleles. . . . . Is the A(SR) deletion also Rz and Rzl defective?. . . . . . . . , . . . . . . . . . . . . . . . . . . . . Epitope-tags on Rz and Rzl genes for localization of Rz1 protein and interaction analysis between Rz and Rzl proteins... in the envelope fractions of infected cells (Kedzierska et al. , 1996). However, this protein species identified in immunoblots as the Rz1 product was not present in the envelope fractions of induced lysogens carrying the I A(SR) prophage, although the deletion...

Zhang, Ning

1999-01-01T23:59:59.000Z

103

An iterative searching and ranking algorithm for prioritising pharmacogenomics genes  

Science Journals Connector (OSTI)

Pharmacogenomics (PGx) studies are to identify genetic variants that may affect drug efficacy and toxicity. A machine understandable drug-gene relationship knowledge is important for many computational PGx studies and for personalised medicine. A comprehensive and accurate PGx-specific gene lexicon is important for automatic drug-gene relationship extraction from the scientific literature, rich knowledge source for PGx studies. In this study, we present a bootstrapping learning technique to rank 33,310 human genes with respect to their relevance to drug response. The algorithm uses only one seed PGx gene to iteratively extract and rank co-occurred genes using 20 million MEDLINE abstracts. Our ranking method is able to accurately rank PGx-specific genes highly among all human genes. Compared to randomly ranked genes (precision: 0.032, recall: 0.013, F1: 0.018), the algorithm has achieved significantly better performance (precision: 0.861, recall: 0.548, F1: 0.662) in ranking the top 2.5% of genes.

Rong Xu; QuanQiu Wang

2013-01-01T23:59:59.000Z

104

Metagenomic gene annotation by a homology-independent approach  

SciTech Connect (OSTI)

Fully understanding the genetic potential of a microbial community requires functional annotation of all the genes it encodes. The recently developed deep metagenome sequencing approach has enabled rapid identification of millions of genes from a complex microbial community without cultivation. Current homology-based gene annotation fails to detect distantly-related or structural homologs. Furthermore, homology searches with millions of genes are very computational intensive. To overcome these limitations, we developed rhModeller, a homology-independent software pipeline to efficiently annotate genes from metagenomic sequencing projects. Using cellulases and carbonic anhydrases as two independent test cases, we demonstrated that rhModeller is much faster than HMMER but with comparable accuracy, at 94.5percent and 99.9percent accuracy, respectively. More importantly, rhModeller has the ability to detect novel proteins that do not share significant homology to any known protein families. As {approx}50percent of the 2 million genes derived from the cow rumen metagenome failed to be annotated based on sequence homology, we tested whether rhModeller could be used to annotate these genes. Preliminary results suggest that rhModeller is robust in the presence of missense and frameshift mutations, two common errors in metagenomic genes. Applying the pipeline to the cow rumen genes identified 4,990 novel cellulases candidates and 8,196 novel carbonic anhydrase candidates.In summary, we expect rhModeller to dramatically increase the speed and quality of metagnomic gene annotation.

Froula, Jeff; Zhang, Tao; Salmeen, Annette; Hess, Matthias; Kerfeld, Cheryl A.; Wang, Zhong; Du, Changbin

2011-06-02T23:59:59.000Z

105

IBM Blue Gene Parallel Supercomputer, Brookhaven National Laboratory, (BNL)  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

L L Overview Simple Example: Compile, Link, Run Compiler Invocation Compile and Link Tips Batch Job Submission Applications Support Math Libraries MPI Version IBM Fortran Blue Gene & Linux Manuals (IBM Redbooks) Much of the info you need will be in the Linux manual, but there is also some Blue Gene-specific info in the Blue Gene manual. Current Fortran compiler version number can be determined on fen by typing: ls /opt/ibmcmp/xlf/bg, will be highest number listed. IBM C/C++ Blue Gene & Linux Manuals (IBM Redbooks) Much of the info you need will be in the Linux manual, but there is also some Blue Gene-specific info in the Blue Gene manual. Linux Manual: Go to XL C/C++ for Linux, choose the Product Library link, then select current version number in tab at page top. (Current C/C++

106

IBM Blue Gene Parallel Supercomputer, Brookhaven National Laboratory, (BNL)  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

How to Login How to Login Please note, New York Blue/L has been decommissioned and these web pages have not yet been updated to reflect its removal from service. The New York Blue/P is now one rack and remains in service. The BNL Blue Gene/Q also remains in service. Introduction Accessing the Blue Gene SSH Gateways Accessing the Blue Gene Front-End Nodes Accessing the Visualization Cluster Accessing the CSC GPU Cluster SSH Tunneling Introduction The only way to access Blue Gene computing resources remotely (outside the Blue Gene network enclave) is through the Blue Gene ssh gateways. Even users connecting from inside the BNL campus network need to go through the gateways. Outside the BNL campus the gateways are known as: ssh.bluegene.bnl.gov Inside the BNL campus they are known as: ssh.bluegene.bnl.local

107

Stitching gene fragments with a network matching algorithm improves gene assembly for metagenomics  

Science Journals Connector (OSTI)

......E-value cutoff (currently set to 0.1). For each reference...nodes without BLAST hits (N is set to 5). This process is repeated...threshold) and (iii) the alignment covers at least 40% of the length of...The identity threshold is set to 60%, since genes may not......

Yu-Wei Wu; Mina Rho; Thomas G. Doak; Yuzhen Ye

2012-09-15T23:59:59.000Z

108

Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.  

Science Journals Connector (OSTI)

...hybridized TPI probe and rehybridized with nick- translated pBR322 DNA. TPI gene and...nitrocellulose, and hybridized with a nick-translated cDNA insert from pHTPI-5a...certain sequences with the TPI promoter that merit mention. These sequences include the GTGGCC...

J R Brown; I O Daar; J R Krug; L E Maquat

1985-07-01T23:59:59.000Z

109

STUDY OF GENE SILENCING IN RICE: A ROOT PREFERENTIAL GENE RCG2  

E-Print Network [OSTI]

involved in the gene silencing of the YXB lines. DNA methylation analysis, northern blotting, RT-PCR and small RNA analysis supported the conclusion that PTGS and TGS are present in the silenced plants. Promoter analysis in silico and using promoter...

Shi, Xiangyu

2010-07-14T23:59:59.000Z

110

From Green to Red: Horizontal Gene Transfer of the Phycoerythrin Gene Cluster between Planktothrix Strains  

Science Journals Connector (OSTI)

...Evolutionary and Genomic Microbiology From Green to Red: Horizontal Gene Transfer of the...phycoerythrin, which are responsible for green and red appearance, respectively. Sequence...that is otherwise more closely related to green strains. Our data show that the insertion...

Ave Tooming-Klunderud; Hanne Sogge; Trine Ballestad Rounge; Alexander J. Nederbragt; Karin Lagesen; Gernot Glckner; Paul K. Hayes; Thomas Rohrlack; Kjetill S. Jakobsen

2013-08-30T23:59:59.000Z

111

Figmop: a profile HMM to identify genes and bypass troublesome gene models in draft genomes  

Science Journals Connector (OSTI)

......sequence. Using a large gene family as a test case, Figmop was found to be more sensitive...but this may not be enough to make and test evolutionary and functional hypotheses...confirmed full-length proteins from the test species. The user runs the MEME software......

David M. Curran; John S. Gilleard; James D. Wasmuth

2014-11-15T23:59:59.000Z

112

Heterocyst Morphogenesis and Gene Expression in Anabaena sp. PCC 7120  

E-Print Network [OSTI]

experiments we found that conR (all0187) gene is necessary for normal septum-formation of vegetative cells, diazotrophic grow, and heterocyst morphogenesis. In our studies we characterized the expression of sigma factors genes in Anabaena PCC 7120 during... are developmentally regulated................... 15 Heterocyst pattern formation requires dynamic signaling............................ 17 II Anabaena SP. STRAIN PCC 7120 GENE conR (ALL0187) CONTAINS A LytR-CpsA-Psr DOMAIN, IS DEVELOPMENTALLY REGULATED...

Mella Herrera, Rodrigo Andres

2010-10-12T23:59:59.000Z

113

Mutator gene and hereditary non-polyposis colorectal cancer  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

2008-02-05T23:59:59.000Z

114

Gene Geracao Eolica Do Nordeste | Open Energy Information  

Open Energy Info (EERE)

Place: Brazil Sector: Wind energy Product: Aims to manufacture and commercialize wind turbines generators between 3 and 10kW. Incubated by Padetec. References: Gene - Geracao...

115

Crystallization of Hfq protein: a bacterial gene-expression regulator  

Science Journals Connector (OSTI)

A global regulator of gene expression in bacteria, Hfq protein, has been crystallized and X-ray diffraction data have been collected to 2.1 ? resolution.

Vassilieva, I.M.

2003-05-23T23:59:59.000Z

116

Gene Controls Flowering Time in Corn - Energy Innovation Portal  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Gene Controls Flowering Time in Corn Great Lakes Bioenergy Research Center Contact GLBRC About This Technology Technology Marketing Summary Plant development is marked by three...

117

Post transcriptional regulation of chloroplast gene expression by nuclear encoded gene products. Progress report, June 1, 1990--June 30, 1992  

SciTech Connect (OSTI)

Many individual chloroplast genes require the products of a collection of nuclear genes for their successful expression. These nuclear gene products apparently work with great specificity, each committed to the expression of a single chloroplast gene. We have chosen as a model nuclear mutants of Chlamydomonas affected in different stages in the expression of the chloroplast encoded Photosystem II polypeptide, D2. We have made the progress in understanding how nuclear gene products affect the translation of the D2 encoding MRNA. Two nuclear genes are required for this process which have been mapped genetically. In contrast to other examples of nuclear control of translation in the chloroplast, these nuclear gene products appear to be required either for specific stages in translation elongation or for the post-translational stabilization of the nascent D2 protein. Pseudoreversion analysis has led us to a locus which may be directly involved in D2 expression. We have made considerable progress in pursuing the molecular basis of psbd MRNA stabilization. psbD 5` UTR specific transcripts have been synthesized in vitro and used in gel mobility shift assays. UV-crosslinking studies are underway to identify the transacting factors which bind to these sequences. The continued examination of these mutants will help us to understand how nuclear gene products work in this specific case of chloroplast gene expression, and will elucidate how two distinct genomes can interact generally.

Kuchka, M.R.

1992-08-01T23:59:59.000Z

118

Evolutionary analyses of nonfamily genes in plants  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

73 73 © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd Received Date : 11-May-2012 Revised Date : 16-Oct-2012 Accepted Date : 07-Nov-2012 Article type : Original Article Evolutionary analyses of non-family genes in plants Chu-Yu Ye 1,2,3,4 , Ting Li 1,3,4 , Hengfu Yin 1 , David J. Weston 1 , Gerald A. Tuskan 1,2 , Timothy J. Tschaplinski 1,2 , Xiaohan Yang 1,2,* 1 Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA 2 BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA 3 Present addresses: Beijing Forestry University, Beijing 100083, China (C.-Y.Y.); Pioneer Hi- Bred International, Johnston, IA 50131, USA (T.L.) 4 These authors contributed equally to this work. * Corresponding author:

119

HumanMouse Gene Identification by Comparative Evidence Integration and  

E-Print Network [OSTI]

The identification of genes in the human genome remains a challenge, as the actual predictions appear to disagree of genes in the human genome by using a reference, such as mouse genome. However, this comparative genome. In particular, it is not clear whether the mouse is at the correct evolutionary distance from

Pavlovic, Vladimir

120

A novel method for finding small highly discriminant gene sets  

E-Print Network [OSTI]

-modified algorithm uses the best aspects of the filter algorithms and the best aspects of the wrapper algorithms to find very small yet highly discriminant gene sets. We also discuss methods to evaluate alternate, ambiguous gene sets. Applying our new mixed model...

Gardner, Jason H.

2004-11-15T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Parallel evolution of chimeric fusion genes Corbin D. Jones*  

E-Print Network [OSTI]

Parallel evolution of chimeric fusion genes Corbin D. Jones* and David J. Begun *Department in Drosophila to guide our analyses. We discovered a fundamental similarity in the temporal, spatial, and types in the evolution of chimeric fusion genes. We suggest that the patterns we observed are both general and predictive

Begun, David

122

Coding Tandem Repeats Generate Diversity in Aspergillus fumigatus Genes  

Science Journals Connector (OSTI)

...Genes containing multiple coding mini- and microsatellite repeats...growth was observed under a grid-mounted Olympus CK inverted...conidia were counted under a grid-mounted Olympus CK inverted...Genes containing multiple coding mini- and microsatellite repeats...

Emma Levdansky; Jacob Romano; Yona Shadkchan; Haim Sharon; Kevin J. Verstrepen; Gerald R. Fink; Nir Osherov

2007-06-08T23:59:59.000Z

123

Analogue Circuit Control through Gene Kester Clegg, Susan Stepney  

E-Print Network [OSTI]

offer an intriguing plat- form for automated design by evolutionary algorithms. Like previous evolvable) or adaptable control (homoeostasis). 1 Background and motivation We present a system for the automated example, ana- logue filters) are modelled as `genes'. Genes are `expressed' in response to circuit output

Stepney, Susan

124

Grouped graphical Granger modeling for gene expression regulatory networks discovery  

Science Journals Connector (OSTI)

......Hinkley (2006) for a review]. More precisely...method to uncover gene regulatory networks for the human...As future work we plan to consider a variant...time-delayed gene regulatory networks based on temporal...et al. Modelling regulatory pathways in E.coli......

Aurlie C. Lozano; Naoki Abe; Yan Liu; Saharon Rosset

2009-06-15T23:59:59.000Z

125

Morphological evolution in land plants: new designs with old genes  

Science Journals Connector (OSTI)

...February 2012 review-article Articles...of their body plans that included...flowers. In this review, we discuss...leaves|flowers|regulatory genes| 1. The...N. 2006 Gene regulatory networks in the...of their body plans that included...flowers. In this review, we discuss...

2012-01-01T23:59:59.000Z

126

DETECTION AND DECOMPOSITION: TREATMENT-INDUCED CYCLIC GENE EXPRESSION  

E-Print Network [OSTI]

*,, , WENSHENG QIN,,|||| and JIN CHEN*,§,§§,|||| *MSU-DOE Plant Research Laboratory Michigan State University-induced disruption of the core set of cyclic genes (which control many downstream pathways) occurs in almost all the disruptions of two core circadian clock genes due to cold treatment in Arabidopsis.9 When a stress treatment

Qin, Wensheng

127

Gene for Improved Nutritional Value in Barley Seed Protein  

Science Journals Connector (OSTI)

...adhere to the starch grains in meal...screening of single seeds without affecting...Acids analysis Cereals Genes, Recessive...Proteins analysis metabolism Seeds analysis Gene...adhere to the starch grains in meal...and selection. Cereals have a low content...

L. Munck; K. E. Karlsson; A. Hagberg; B. O. Eggum

1970-05-22T23:59:59.000Z

128

Prediction of Complete Gene Structures in Human Genomic DNA  

E-Print Network [OSTI]

and RNA splicing. On the other hand, with the recent shift in the emphasis of the Human Genome ProjectPrediction of Complete Gene Structures in Human Genomic DNA Chris Burge* and Samuel Karlin model of the gene structure of human genomic sequences which incorporates descriptions of the basic

Shatkay, Hagit

129

Characterization of candidate genes in English cocker spaniel hereditary nephritis  

E-Print Network [OSTI]

Six different isoforms of Type IV collagen (colIV?1-6) have been identified. The individual isoforms of colIV are termed alpha chains and are translated from six different COLIV genes (COLIVA1-A6). Collagen Type IV gene products compose...

Camacho, Zenaido

2005-02-17T23:59:59.000Z

130

GenePRIMP: A software quality control tool  

ScienceCinema (OSTI)

Amrita Pati of the DOE Joint Genome Institute's Genome Biology group describes the software tool GenePRIMP and how it fits into the quality control pipeline for microbial genomics. Further details regarding GenePRIMP appear in a paper published online May 2, 2010 in Nature Methods.

Amrita Pati

2010-09-01T23:59:59.000Z

131

Issue: April 2013 Algae Go to Extremes with "Borrowed" Genes  

E-Print Network [OSTI]

Issue: April 2013 Algae Go to Extremes with "Borrowed" Genes by Patricia Waldron Brand-New Genes their extreme environment. For example, some bacteria that live at high temperatures have special molecules that are highly acidic, or full of toxic metals. While most microbes that live in extreme environments

Schönknecht, Gerald

132

Comprehensive detection of cancer gene expression profiles and gene networks are impacted by the choice of pre-processing algorithm and gene-selection method  

Science Journals Connector (OSTI)

Pre-processing algorithms (PPA) and gene-selection methods (GSM) are commonly employed to select Differentially Expressed Genes (DEGs) from microarray data. Previous studies established that different combinations of PPAs and GSMs are intrinsically different in their performance to select biologically relevant DEGs. In this study, we evaluated eight combinations of PPAs and GSMs for their ability to select DEGs for prioritising gene-networks. Although the different combinations yielded dissimilar DEG-lists, all DEG-lists selected could segregate tumour from normal. Nevertheless, the DEG-list selected significantly impacted the prioritisation of cancer-associated gene-networks; hence the initial choice of PPA and GSM is crucial for subsequent interactome investigations.

N. Baskaran; Chee Keong Kwoh; Kam M. Hui

2013-01-01T23:59:59.000Z

133

BESC Submits 32 Gene Disclosures for Patents | ORNL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

News Careers Work with ORNL About ORNL Visiting ORNL Events and Conferences Highlights Success Stories Contact Us Index Home | ORNL | Highlights SHARE BESC submits 32 gene disclosures for future patents July 01, 2012 Plant geneticist Wellington Muchero examines phenotypic traits of Populus transgenic lines grown in a greenhouse. The Bioenergy Science Center (BESC) at Oak Ridge National Laboratory (ORNL) is preparing invention disclosures for 32 different genes that can help improve the yield of ethanol from cellulosic biomass. These genes or their variants function to overcome recalcitrance-difficulty in breaking down cellulosic biomass to release sugars. Several members of ORNL's Biosciences Division are submitting disclosures: 16 genes by Wellington Muchero, 10 genes by Udaya Kalluri, and

134

Cell number regulator genes in Prunus provide candidate genes for the control of fruit size in sweet and sour cherry  

E-Print Network [OSTI]

Cell number regulator genes in Prunus provide candidate genes for the control of fruit size at Springerlink.com Abstract Striking increases in fruit size distinguish cultivated descendants from small-fruited wild progen- itors for fleshy fruited species such as Solanum lycopersicum (tomato) and Prunus spp

van der Knaap, Esther

135

Ontogenomic study of the relationship between number of gene splice variants and GO categorization  

Science Journals Connector (OSTI)

......Ashburner et al., 2000a; Gene Ontology Consortium, 2006; Little...has been analyzed. The Gene Ontology (GO; Ashburner et al., 2000b; Gene Ontology Consortium, 2006) and tools...form of clustered image map (CIM) highlighted GO categories......

Ari B. Kahn; Barry R. Zeeberg; Michael C. Ryan; D. Curtis Jamison; David M. Rockoff; Yves Pommier; John N. Weinstein

2010-08-15T23:59:59.000Z

136

E-Print Network 3.0 - amp-binding protein gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 protein... 19 GENE2147X KIAA0282 KIAA0282 protein GENE2906X Homo sapiens cDNA FLJ13700 fis, clone PLACE2000216... GENE3053X HMGIY high-mobility group (nonhistone ... Source:...

137

E-Print Network 3.0 - arenaviruses genes proteins Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 protein... 19 GENE2147X KIAA0282 KIAA0282 protein GENE2906X Homo sapiens cDNA FLJ13700 fis, clone PLACE2000216... GENE3053X HMGIY high-mobility group (nonhistone ... Source:...

138

A Linear Discrete Dynamic System Model for Temporal Gene Interaction and Regulatory  

E-Print Network [OSTI]

significantly expressed genes in response to bioethanol conversion inhibitor 5-hydroxymethylfurfural model, esti- mated from time course gene expression measurements during the earlier exposure to 5-hydroxymethylfurfural, reveals known transcriptional reg- ulations as well as potential significant genes involved

Song, Joe

139

E-Print Network 3.0 - adaptive gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in splice site predictors adapted from the Gene... A Critical Review of Gene Prediction Software Mark ... Source: Bejerano, Gill - Departments of Computer Science & Developmental...

140

Gene expression in human fungal pathogen Coccidioides immitis changes as arthroconidia differentiate into spherules and mature  

E-Print Network [OSTI]

transform- ation is the alpha amylase (AMY1) gene. This geneJT, Goldman WE: An alpha-(1,4)-amylase is essential for

Viriyakosol, Suganya; Singhania, Akul; Fierer, Joshua; Goldberg, Jonathan; Kirkland, Theo N; Woelk, Christopher H

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

E-Print Network 3.0 - adenoviral gene therapy Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Stanford University Collection: Biology and Medicine 46 THE JOURNAL OF GENE MEDICINE RESEARCH ARTICLE J Gene Med 2003; 5: 300310. Summary: . Alvarez RD, Gomez-Navarro J, Wang...

142

E-Print Network 3.0 - alpha gene family Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

birds, such as expansions in the keratin gene family, which are the pro- teinaceous building... in the study of gene family evolution. ... Source: Kellis, Manolis - Computer...

143

E-Print Network 3.0 - active genes based Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biology and Medicine 69 GeneTracer: Gene Sequence Analysis of Disease Mutations VAST 2010 Mini Challenge 3 Award: Excellent Process Explanation Summary: for a disease outbreak,...

144

E-Print Network 3.0 - acads gene variation Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of vertebrate gene deserts Summary: deserts). However, there is a wide variation in ECR density among different gene deserts, which cannot... Evolution and functional...

145

E-Print Network 3.0 - acetyl-coa carboxylase-alpha gene Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is to deter- mine the biological function of all the gene pro... microbial genomes highlights the need for func- tional characterization of the gene ... Source: Gerstein,...

146

E-Print Network 3.0 - anemia gene facc Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

FRAMEWORKS FOR ENGINEERS Summary: disease and nature of the mutation that leads to Sickle Cell Anemia? E. The gene defective in Sickle Cell... Anemia is a recessive gene....

147

E-Print Network 3.0 - abca3 gene leads Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 11 RESOVING THE GENE TREE AND SPECIES TREE PROBLEM BY PHYLOGENETIC MINING Summary: RESOVING THE GENE TREE AND SPECIES TREE PROBLEM BY PHYLOGENETIC MINING XIAOXU...

148

E-Print Network 3.0 - arsenite oxidase gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

gene pgpA in arsenite-resistant Leishmania tarentolae. EMBO J 16: 30573065 Howell N, Gilbert K... (1989) Internal frameshifts within the mitochondrial genes for cytochrome ......

149

E-Print Network 3.0 - acquired cns gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: . Then, in the insect lineage, maternal expression of zen was lost and the bcd gene was acquired through... genes in different lineages have one, two or three...

150

E-Print Network 3.0 - adenoviral gene delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for both inter and intra species gene therapy delivery in adults. The gene therapy vehicle is tolerated... cell potential Nonviral delivery of selected ... Source:...

151

Low-Oxygen Induction of Normally Cryptic psbA Genes in Cyanobacteria...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Oxygen Induction of Normally Cryptic psbA Genes in Cyanobacteria. Low-Oxygen Induction of Normally Cryptic psbA Genes in Cyanobacteria. Abstract: Microarray analysis indicated...

152

E-Print Network 3.0 - autism candidate gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

, presumably causing ASD. For extracting ASD candidate genes, we developed an analysis pipeline for rare... Atlas", ASD candidate genes have ... Source: Hochreiter, Sepp -...

153

Apoptotic detection methods from morphology to gene  

Science Journals Connector (OSTI)

To date, many terms have been given for cell death and forgotten before they became widely accepted. Most researchers studying cell death use some terms for cell death that have survived over centuries and regard apoptosis and programmed cell death (PCD), and necrosis and oncosis as synonymous. The different terminologies used for cell death depending on the preference of researchers sometimes cause confusion in the study of apoptosis. The study of apoptosis was first based on cell morphology using transmission electron microscopy (TEM): chromatin condensation, cellular shrinkage, budding and apoptotic body formation. Recently, marked progress in biochemistry, molecular biology and genetics provided researchers of apoptosis various tools for apoptotsis detection, such as the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end-labeling (TUNEL) method, agarose gel electrophoresis using extracted DNA, staining methods using fluorescence dyes, and flow cytometry. This review focuses on the following topics: history of the study of cell death and its classification, apoptosis-related proteins and their signal pathways, morphological, biochemical and molecular biological methods of apoptosis detection, and the transcriptional regulation of bcl-2 using the real-time Southwestern method and cancer gene therapy. In addition, the merits and demerits of the above-mentioned apoptosis detection methods are discussed.

Yoshinori Otsuki; Zhonglian Li; Masa-Aki Shibata

2003-01-01T23:59:59.000Z

154

Mutational analysis of the [phi] X174 E Gene  

E-Print Network [OSTI]

for the rapid isolation and sequencing of E gene mutants from the screening vector pSM120 has been developed. Two nonsense mutations have been isolated which totally inactivate the E gene product. A variety of amino acids have been inserted at these non... Hydroxylami ne mutagenesis Transformation 13 16 18 19 29 29 30 30 32 33 33 36 38 38 TABLE OF CONTENTS (continued) Selection of gene E mutations in pSM120 M13 cloning and dideoxy sequencing 3. RESULTS Characterization of deletion clones...

Morham, Scott Garton

1985-01-01T23:59:59.000Z

155

Analysis of the [lambda] S? gene function by mutational suppressors  

E-Print Network [OSTI]

the ssb-ral region. The ~sl C mutation which confers resistance to the plasmid borne S gene was mapped to 3 min on the E. coli chromosome and shown to impart a 6-9 minute delay in lysis by wild type The lysis regulator proposed by Campbell and Rolfe... genes transcribed from the strong pR' promoter, beginning about 8-10 minutes after induction of a l lysogen. The product of the R gene is a transglycosylase or endolysin (Campbell and Rolfe, 1975; Bienkowska and Taylor, 1980; Bienkowska et al...

Sohaskey, Charles David

2012-06-07T23:59:59.000Z

156

Single, Key Gene Discovery Could Streamline Production of Biofuels |  

Broader source: Energy.gov (indexed) [DOE]

Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels August 11, 2011 - 3:51pm Addthis WASHINGTON, DC -- A team of researchers at the Department of Energy's BioEnergy Science Center (BESC) have pinpointed the exact, single gene that controls ethanol production capacity in a microorganism. This discovery could be the missing link in developing biomass crops that produce higher concentrations of ethanol at lower costs. "The Department of Energy relies on the scientific discoveries of its labs and research centers to improve the production of clean energy sources," said Energy Secretary Steven Chu. "This discovery is an important step in developing biomass crops that could increase yield of

157

; Evolution of genes and genomes on the Drosophila phylogeny  

E-Print Network [OSTI]

ARTICLES ; Evolution of genes and genomes on the Drosophila phylogeny Drosophila 12 Genomes Consortium* Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome

Kellis, Manolis

158

Visually Relating Gene Expression and in vivo DNA Binding Data  

SciTech Connect (OSTI)

Gene expression and in vivo DNA binding data provide important information for understanding gene regulatory networks: in vivo DNA binding data indicate genomic regions where transcription factors are bound, and expression data show the output resulting from this binding. Thus, there must be functional relationships between these two types of data. While visualization and data analysis tools exist for each data type alone, there is a lack of tools that can easily explore the relationship between them. We propose an approach that uses the average expression driven by multiple of ciscontrol regions to visually relate gene expression and in vivo DNA binding data. We demonstrate the utility of this tool with examples from the network controlling early Drosophila development. The results obtained support the idea that the level of occupancy of a transcription factor on DNA strongly determines the degree to which the factor regulates a target gene, and in some cases also controls whether the regulation is positive or negative.

Huang, Min-Yu; Mackey, Lester; Ker?; nen, Soile V. E.; Weber, Gunther H.; Jordan, Michael I.; Knowles, David W.; Biggin, Mark D.; Hamann, Bernd

2011-09-20T23:59:59.000Z

159

Circadian clock genes and risk of fatal prostate cancer  

Science Journals Connector (OSTI)

Circadian genes may be involved in regulating cancer-related pathways, including cell proliferation, DNA damage response, and apoptosis. We aimed to assess the role of genetic variation in core circadian rhyth...

Sarah C. Markt; Unnur A. Valdimarsdottir; Irene M. Shui

2014-11-01T23:59:59.000Z

160

Scaling up accurate phylogenetic reconstruction from gene-order data  

Science Journals Connector (OSTI)

......not a problem; for nuclear genomes with a thousand...workable size. Thus datasets of nuclear genomes with large pairwise...computation. As larger datasets of gene-order data...to the much larger nuclear genomes (thousands......

Jijun Tang; Bernard M.E. Moret

2003-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Low-Rank Regularization for Learning Gene Expression Programs  

E-Print Network [OSTI]

8 | Issue 12 | e82146 Low-Rank for Learning Gene Expressiona convex relaxation of the rank of W [22,23]. Since nuclearcall (3) the linear low-rank model in the following. The

Ye, Guibo; Tang, Mengfan; Cai, Jian-Feng; Nie, Qing; Xie, Xiaohui; Muldoon, Mark R

2013-01-01T23:59:59.000Z

162

Polyelectrolyte-based Nanoparticles for Gene and Protein Delivery  

E-Print Network [OSTI]

were used to systematically inspect gene transfection efficiency and cytotoxicity. Transfection efficiency of non-degradable nanogels increased with increasing amounts of positive charge. Intriguingly, acid-labile nanogels bearing low charge showed...

Khondee, Supang

2011-05-31T23:59:59.000Z

163

A mathematical programming approach for gene selection and tissue classification  

Science Journals Connector (OSTI)

......programming approach for gene selection...Department of Management Science and Statistics...programming approach can rival...Department of Management Science and Statistics...Innovative Approaches to the Science of Management . Quorum Books......

Minghe Sun; Momiao Xiong

2003-07-01T23:59:59.000Z

164

Dynamics of gene expression and signal transduction in single cells  

E-Print Network [OSTI]

Each individual cell is a highly dynamic and complex system. Characterizing dynamics of gene expression and signal transduction is essential to understand what underlie the behavior of the cell and has stimulated much ...

Yang, Qiong, Ph. D. Massachusetts Institute of Technology

2009-01-01T23:59:59.000Z

165

The zebrafish progranulin gene family and antisense transcripts  

Science Journals Connector (OSTI)

The progranulin gene family in zebrafish has four members encoding growth factors that evolved from a single ancestor, as is seen in mammals. Their diverse structural makeup and distinct expression patterns point to diversified functions in the four fish proteins.

Benot Cadieux; Babykumari P Chitramuthu; David Baranowski; Hugh PJ Bennett

2005-11-08T23:59:59.000Z

166

4.2 Selection Changes in gene frequency  

E-Print Network [OSTI]

the best-known example of this situation in man concerns the phenomenon of sickle-cell anaemia. The maintenance of high frequencies for both the sickle cell gene and its normal allele in certain East African

Hsu, Sze-Bi

167

Brief Communication 1195 A gene trap approach in Xenopus  

E-Print Network [OSTI]

developed several gene trap vectors, using the green fluorescent protein (GFP) as a marker. Using, including expression in the epiphysis, the olfactory bulb and placodes, the eyes, ear, brain, muscles, tail

Amaya, Enrique

168

Expression of Genes Linked to NOx Detoxification in Aerobic Bacteria  

E-Print Network [OSTI]

operons referred to as the nif cluster. This suite of genesgenes not found in the nif clusters of K. pneumoniae (i.e.is high conservation among nif gene organization based on

Cua, Lynnie

2010-01-01T23:59:59.000Z

169

Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine  

E-Print Network [OSTI]

We mechanistically explored the effect of increased hydrophobicity of the polycation on the efficacy and specificity of gene delivery in mice. N-Alkylated linear PEIs with varying alkyl chain lengths and extent of substitution ...

Fortune, Jennifer A.

170

RESEARCH Open Access Gene expression and fractionation resistance  

E-Print Network [OSTI]

in Paramecium, Gout et al. [10] identify a clear relationship between high WGD duplicate gene retention rates for explaining variable resistance to fractionation. The Gout et al. paper [10] is the primary inspiration

Sankoff, David

171

A compendium of gene expression in normal human tissues  

E-Print Network [OSTI]

Gene Expression Index, the HuGE In- dex, http://www.hugeindex.org) for future studies of patho completion of the human genome project (8, 37a), greater attention is now focused on defining the biological

Weng, Zhiping

172

PI Control of Gene Expression in Tumorous Cell Lines  

E-Print Network [OSTI]

3 HT29 cell line data for starved and then fed 20% FBS group (Group 1), starved with no FBS group (Group 2), and no starvation group (Group 3) for the genes JUN, MYC, and EGR1......................................................... 15 4... Normalized HEK cell line data for starved and then fed 20% FBS group (Group 1), starved with no FBS group (Group 2), and no starvation group (Group 3) for the genes JUN, MYC, and EGR1........................................ 16 5 Normalized HT29 cell...

Mendonca, Rouella J.

2010-01-16T23:59:59.000Z

173

Adaptations to Endosymbiosis in a Cnidarian- Dinoflagellate Association: Differential Gene Expression and Specific Gene Duplications  

E-Print Network [OSTI]

Trophic endosymbiosis between anthozoans and photosynthetic dinoflagellates forms the key foundation of reef ecosystems. Dysfunction and collapse of symbiosis lead to bleaching (symbiont expulsion), which is responsible for the severe worldwide decline of coral reefs. Molecular signals are central to the stability of this partnership and are therefore closely related to coral health. To decipher inter-partner signaling, we developed genomic resources (cDNA library and microarrays) from the symbiotic sea anemone Anemonia viridis. Here we describe differential expression between symbiotic (also called zooxanthellate anemones) or aposymbiotic (also called bleached) A. viridis specimens, using microarray hybridizations and qPCR experiments. We mapped, for the first time, transcript abundance separately in the epidermal cell layer and the gastrodermal cells that host photosynthetic symbionts. Transcriptomic profiles showed large inter-individual variability, indicating that aposymbiosis could be induced by different pathways. We defined a restricted subset of 39 common genes that are characteristic of the symbiotic or aposymbiotic states. We demonstrated that transcription of many genes belonging to this set is specifically enhanced in the symbiotic cells (gastroderm). A model is proposed where the aposymbiotic and therefore heterotrophic state triggers vesicular trafficking, whereas the symbiotic and therefore autotrophic state favors metabolic exchanges between host and symbiont. Several genetic pathways were investigated in more detail: i) a key vitamin Kdependant process involved in the dinoflagellate-cnidarian recognition; ii) two cnidarian

Aurlie Moya; Virginie Magnone; Denis Allem; Paola Furla; Ccile Sabourault

174

Deinococcus geothermalis: The Pool of Extreme Radiation Resistance Genes Shrinks  

SciTech Connect (OSTI)

The whole-genome sequence of Deinococcus geothermalis is the second for an extremely ionizing radiation (IR) resistant bacterium. The first was for Deinococcus radiodurans, which for 50 years has been the subject of extensive investigations aimed at solving the mystery of how this microbe can survive immense doses of ?-rays. So far, comparative analyses between the genome of D. radiodurans and genomes of other bacteria have failed to produce a coherent picture of the underlying resistance systems. Most surprisingly, many critical DNA repair genes identified in D. radiodurans are present in sensitive bacteria, whereas the involvement of many uncharacterized genes implicated in resistance by transcriptome analyses has not been borne out by mutant studies. Genomic subtraction of D. geothermalis from D. radiodurans was used to define a minimal gene set for extreme resistance, whereby unique genes were ruled out, and shared genes were pooled as candidates for resistance. We revise down substantially the number of potential genetic determinants of extreme radiation resistance, identify a putative regulator and a palindromic binding site for genes which comprise a distinct Deinococcus radiation response regulon, and consider the impact of those findings on the prevailing models of extreme radiation resistance.

Makarova, Kira S.; Omelchenko, M. V.; Gaidamakova, E.; Matrosova, V.; Vasilenko, A.; Zhai, M.; Lapidus, Alla; Copeland, A.; Kim, E.; Land, M.; Mavromatis, Konstantinos; Pitluck, S.; Richardson, P. M.; Detter, J. C.; Brettin, T.; Saunders, Elizabeth; Lai, Barry; Ravel, B.; Kemmer, K. M.; Wolf, Y. I.; Sorokin, Alexander; Gerasimova, A. V.; Gelfand, Mikhail S.; Fredrickson, Jim K.; Koonin, Eugene V.; Daly, M. J.

2007-09-26T23:59:59.000Z

175

Glucose Regulates the Expression of the Apolipoprotein A5 Gene  

SciTech Connect (OSTI)

The apolipoprotein A5 gene (APOA5) is a key player in determining triglyceride concentrations in humans and mice. Since diabetes is often associated with hypertriglyceridemia, this study explores whether APOA5 gene expression is regulated by alteration in glucose homeostasis and the related pathways. D-glucose activates APOA5 gene expression in a time- and dose-dependent manner in hepatocytes, and the glycolytic pathway involved was determined using D-glucose analogs and metabolites. Together, transient transfections, electrophoretic mobility shift assays and chromatin immunoprecipitation assays show that this regulation occurs at the transcriptional level through an increase of USF1/2 binding to an E-box in the APOA5 promoter. We show that this phenomenon is not due to an increase of mRNA or protein expression levels of USF. Using protein phosphatases 1 and 2A inhibitor, we demonstrate that D-glucose regulates APOA5 gene via a dephosphorylation mechanism, thereby resulting in an enhanced USF1/2-promoter binding. Last, subsequent suppressions of USF1/2 and phosphatases mRNA through siRNA gene silencing abolished the regulation. We demonstrate that APOA5 gene is up regulated by D-glucose and USF through phosphatase activation. These findings may provide a new cross talk between glucose and lipid metabolism.

Fruchart, Jamila; Nowak, Maxime; Helleboid-Chapman, Audrey; Jakel, Heidelinde; Moitrot, Emmanuelle; Rommens, Corinne; Pennacchio, Len A.; Fruchart-Najib, Jamila; Fruchart, Jean-Charles

2008-04-07T23:59:59.000Z

176

Confirmation of the chromosomal localization of human lamp genes and their exclusion as candidate genes for Salla disease  

Science Journals Connector (OSTI)

Salla disease is an inherited lysosomal storage disorder caused by accumulation of free sialic acid in the lysosomes. Lamp genes, lamp A and lamp B (lysosome associated membrane proteins), are the first known ...

Johanna Schleutker; Leena Haataja; Martin Renlund; Lea Puhakka

1991-11-01T23:59:59.000Z

177

Efficient mutagenesis of the rhodopsin gene in rod photoreceptor neurons in mice  

E-Print Network [OSTI]

, 2011; Accepted March 17, 2011 ABSTRACT Dominant mutations in the rhodopsin gene, which is expressed

Wensel, Theodore G.

178

Analysis of mixed C-means clustering approach for brain tumour gene expression data  

Science Journals Connector (OSTI)

Data mining has become an important topic in effective analysis of gene expression data due to its wide application in the biomedical industry. A gene cluster is a set of two or more genes that serve to encode for the same or similar products. Gene clustering ...

S. Selva Kumar; H. Hannah Inbarani

2013-05-01T23:59:59.000Z

179

Gene expression profiling of candidate genes in peripheral blood mononuclear cells for predicting toxicity of diesel exhaust particles  

Science Journals Connector (OSTI)

Abstract To validate gene expression profiling of peripheral blood mononuclear cells (PBMCs) as a surrogate for monitoring tissue expression, this study using RT-PCR-based TaqMan low-density array (TLDA) was initiated to investigate similarities in the mRNA expression of target genes altered by exposure to diesel exhaust particles (DEPs) in freshly prepared \\{PBMCs\\} and in lungs. Adult Wistar rats were treated transtracheally with a single dose of 7.5 or 15 or 30mg/kg \\{DEPs\\} and sacrificed 24h later. Blood and lungs were immediately taken out and processed for RT-PCR. DEP treatment induced similar patterns of increase in the expression of polycyclic aromatic hydrocarbon-responsive cytochrome P450s, the phase II enzymes, and their associated transcription factors in both lungs and PBMCs, at all doses. Similar to that seen in lungs, a dose-dependent increase was observed in the expression of genes involved in inflammation, such as cytokines, chemokines, and adhesion molecules, in PBMCs. The expression of various genes involved in DNA repair and apoptosis was also increased in a dose-dependent manner in \\{PBMCs\\} and lungs. The present TLDA data indicating similarities in the responsiveness of candidate genes involved in the toxicity of \\{DEPs\\} between \\{PBMCs\\} and lungs after exposure to \\{DEPs\\} demonstrate that expression profiles of genes in \\{PBMCs\\} could be used as a surrogate for monitoring the acute toxicity of fine and ultrafine particulate matter present in vehicular emissions.

Ankita Srivastava; Amit Sharma; Sanjay Yadav; Swaran J.S. Flora; Uppendra N. Dwivedi; Devendra Parmar

2014-01-01T23:59:59.000Z

180

Biochemical and genetic analysis of hydrogen metabolism in Escherichia coli: The hydB gene. [Hydrogenase  

SciTech Connect (OSTI)

Production of active hyrodgenase by Escherichia coli requires several gene products. One of the essential genes, hydB, is encoded by a DNA fragment of approximately 1.0 kilobase. The hydB gene produced a protein with an apparent molecular weight of 32,000. The hydB gene was transcribed only under anaerobic conditions. Oxygen and nitrate repressed transcription of this gene. hydB gene transcription also required {sigma}{sup 60}, the product of the rpoN gene.

Sankar, P.; Shanmugam, K.T. (Univ. of Florida, Gainesville (USA))

1988-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Supplementary Figure 1: Bayesian 50% majority-rule consensus trees for the combined dataset of mitochondrial genes (left) and nuclear genes (right). Color coding distinguishes  

E-Print Network [OSTI]

1 Supplementary Figure 1: Bayesian 50% majority-rule consensus trees for the combined dataset of mitochondrial genes (left) and nuclear genes (right). Color coding distinguishes groups supported by PP 99 for individual nuclear genes: Rag-1, Rag-2 and C-mos. Color coding distinguishes groups supported by PP 99

182

Running Title: LXR Regulated Genes in As4.1 cells Identification of a Novel Set of Genes Regulated by a Unique LXR-Mediated  

E-Print Network [OSTI]

Running Title: LXR Regulated Genes in As4.1 cells 1 Identification of a Novel Set of Genes Regulated by a Unique LXR-Mediated Transcription Mechanism Leonard M. Anderson1 , Sung E. Choe2 , Rustam Y, Genomic #12;Running Title: LXR Regulated Genes in As4.1 cells 2 SUMMARY We have reported previously

Church, George M.

183

Chitosan-based therapeutic nanoparticles for combination gene therapy and gene silencing of in vitro cell lines relevant to type 2 diabetes  

E-Print Network [OSTI]

Chitosan-based therapeutic nanoparticles for combination gene therapy and gene silencing 2011 Keywords: Type 2 diabetes Glucagon like peptide 1 Dipeptydil-peptidase IV siRNA Chitosan Gene-IV) endoprotease. In this study, the glucosamine-based polymer chitosan was used as a cationic polymer

Buschmann, Michael

184

Promoter sequence of 3-phosphoglycerate kinase gene 2 of lactic acid-producing fungus rhizopus oryzae and a method of expressing a gene of interest in fungal species  

DOE Patents [OSTI]

The present invention provides the promoter clone discovery of phosphoglycerate kinase gene 2 of a lactic acid-producing filamentous fungal strain, Rhizopus oryzae. The isolated promoter can constitutively regulate gene expression under various carbohydrate conditions. In addition, the present invention also provides a design of an integration vector for the transformation of a foreign gene in Rhizopus oryzae.

Gao, Johnway [Richland, WA; Skeen, Rodney S [Pendleton, OR

2003-03-04T23:59:59.000Z

185

A functional gene array for detection of bacterial virulence elements  

SciTech Connect (OSTI)

We report our development of the first of a series of microarrays designed to detect pathogens with known mechanisms of virulence and antibiotic resistance. By targeting virulence gene families as well as genes unique to specific biothreat agents, these arrays will provide important data about the pathogenic potential and drug resistance profiles of unknown organisms in environmental samples. To validate our approach, we developed a first generation array targeting genes from Escherichia coli strains K12 and CFT073, Enterococcus faecalis and Staphylococcus aureus. We determined optimal probe design parameters for microorganism detection and discrimination, measured the required target concentration, and assessed tolerance for mismatches between probe and target sequences. Mismatch tolerance is a priority for this application, due to DNA sequence variability among members of gene families. Arrays were created using the NimbleGen Maskless Array Synthesizer at Lawrence Livermore National Laboratory. Purified genomic DNA from combinations of one or more of the four target organisms, pure cultures of four related organisms, and environmental aerosol samples with spiked-in genomic DNA were hybridized to the arrays. Based on the success of this prototype, we plan to design further arrays in this series, with the goal of detecting all known virulence and antibiotic resistance gene families in a greatly expanded set of organisms.

Jaing, C

2007-11-01T23:59:59.000Z

186

Deinococcus geothermalis: The Pool of Extreme Radiation Resistance Genes Shrinks  

SciTech Connect (OSTI)

Bacteria of the genus Deinococcus are extremely resistant to ionizing radiation (IR), ultraviolet light (UV) and desiccation. The mesophile Deinococcus radiodurans was the first member of this group whose genome was completely sequenced. Analysis of the genome sequence of D. radiodurans, however, failed to identify unique DNA repair systems. To further delineate the genes underlying the resistance phenotypes, we report the whole-genome sequence of a second Deinococcus species, the thermophile Deinococcus geothermalis, which at itsoptimal growth temperature is as resistant to IR, UV and desiccation as D. radiodurans, and a comparative analysis of the two Deinococcus genomes. Many D. radiodurans genes previously implicated in resistance, but for which no sensitive phenotype was observed upon disruption, are absent in D. geothermalis. In contrast, most D. radiodurans genes whose mutants displayed a radiation-sensitive phenotype in D. radiodurans are conserved in D. geothermalis. Supporting the existence of a Deinococcus radiation response regulon, a common palindromic DNA motif was identified in a conserved set of genes associated with resistance, and a dedicated transcriptional regulator was predicted. We present the case that these two species evolved essentially the same diverse set of gene families, and that the extreme stress-resistance phenotypes of the Deinococcus lineage emerged progressively by amassing cell-cleaning systems from different sources, but not by acquisition of novel DNA repair systems. Our reconstruction of the genomic evolution of the Deinococcus-Thermus phylum indicates that the corresponding set of enzymes proliferated mainly in the common ancestor of Deinococcus. Results of the comparative analysis weaken the arguments for a role of higher-order chromosome alignment structures in resistance; more clearly define and substantially revise downward the number of uncharacterized genes that might participate in DNA repair and contribute to resistance; and strengthen the case for a role in survival of systems involved in manganese and iron homeostasis.

Makarova, Kira S.; Omelchenko, Marina V.; Gaidamakova, Elena K.; Matrosova, Vera Y.; Vasilenko, Alexander; Zhai, Min; Lapidus, Alla; Copeland, Alex; Kim, Edwin; Land, Miriam; Mavrommatis, Konstantinos; Pitluck, Samuel; Richardson, Paul M.; Detter, Chris; Brettin, Thomas; Saunders, Elizabeth; Lai, Barry; Ravel, Bruce; Kemner, Kenneth M.; Wolf, Yuri I.; Sorokin, Alexander; Gerasimova, Anna V.; Gelfand, Mikhail S.; Fredrickson, James K.; Koonin, Eugene V.; Daly, Michael J.

2007-07-24T23:59:59.000Z

187

Modelling gene functional linkages using yeast microarray data  

Science Journals Connector (OSTI)

Understanding how genes are functionally related requires efficient algorithms to model networks from expression data. We report a heuristic search algorithm called Two-Level Simulated Annealing (TLSA) that is more likely to find the global optimal network structure compared to conventional simulated annealing and other searching schemes. We have applied this method to search for a global optimised network structure from a synthetic data set and an expression data set of S. cerevisiae mutants. We have achieved better precision and recall compared to other searching algorithms and are able to map relationships more accurately among functionally-linked genes.

Tie Wang; Guoliang Xue; Jeffrey W. Touchman

2007-01-01T23:59:59.000Z

188

The lysis genes of bacteriophage 21: structure and function  

E-Print Network [OSTI]

(Campbell and Rolfe, 1975, Garret et al. , 1981). The most distal gene in the lysis "overlappon", le, is of unknown function and is required for lysis only under conditions of high osmolarity such as 10mH HgC12 (Young et al. , 1979). The fl gene encodes.... As mentioned above, respiratory poisons such as cyanide or dinitrophenol have been shown to trigger pg pr'ematurely in the lytic cycle, presumably by subverting the delayed action timing of pS (Campbell and Rolfe, 1975, Garret et al. , 1981). This model...

Bonovich, Maria Teresa

2012-06-07T23:59:59.000Z

189

Isolation and characterization of Agouti: a diabetes/obesity related gene  

DOE Patents [OSTI]

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

Woychik, Richard P. (Knoxville, TN)

2000-06-27T23:59:59.000Z

190

Isolation and characterization of Agouti: a diabetes/obesity related gene  

DOE Patents [OSTI]

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

Woychik, Richard P. (Knoxville, TN)

1998-01-01T23:59:59.000Z

191

Genome Organization and Gene Expression Shape the Transposable Element Distribution  

E-Print Network [OSTI]

Genome Organization and Gene Expression Shape the Transposable Element Distribution The distribution of transposable elements (TEs) in a genome reflects a balance between insertion rate and selection shaping the organization of genomes. Past research has shown that TEs tend to accumulate in genomic

Alvarez, Nadir

192

Genes order and phylogenetic reconstruction: application to #Proteobacteria  

E-Print Network [OSTI]

@lacim.uqam.ca Abstract. We study the problem of phylogenetic reconstruction based on gene order for whole genomes. We define three genomic distances between whole genomes represented by signed sequences, based­ logeny for a group of 12 complete genomes of #­Proteobacteria. Keywords: Phylogenetic reconstruction

Fertin, Guillaume

193

Genes order and phylogenetic reconstruction: application to -Proteobacteria  

E-Print Network [OSTI]

@lacim.uqam.ca Abstract. We study the problem of phylogenetic reconstruction based on gene order for whole genomes. We define three genomic distances between whole genomes represented by signed sequences, based- logeny for a group of 12 complete genomes of -Proteobacteria. Keywords: Phylogenetic reconstruction

Fertin, Guillaume

194

Gene Delivery DOI: 10.1002/anie.201302820  

E-Print Network [OSTI]

(10­25 peptide residues) and lack adequate cationic charge to efficiently condense and deliver genes vehicles to improve delivery efficiencies.[11] We recently developed high-molecular-weight (MW), cationic efficiency and chemotoxicity of these polymeric vectors are often closely related to the density

Cheng, Jianjun

195

The genes that turned wildcats into kitty cats  

Science Journals Connector (OSTI)

...humans as well. We're hitting on genes that allow our brains to develop and make us interact socially. The team also...explaining why domestic animals share common traits, such as smaller brains and certain pigmentation patternsa mystery first noted...

David Grimm

2014-11-14T23:59:59.000Z

196

Identification of Genes Expressed in Malignant Cells That Promote Invasion  

Science Journals Connector (OSTI)

...vacuum. The resulting space was filled with tumor...and Analysis of SAGE Libraries. SAGE libraries for...described (24) . The SAGE libraries corresponding to each...proprietary database or the public Gene Expression Omnibus...information for the libraries. Tag counts were normalized...

Jennifer Walter-Yohrling; Xiaohong Cao; Michele Callahan; William Weber; Sharon Morgenbesser; Stephen L. Madden; Clarence Wang; and Beverly A. Teicher

2003-12-15T23:59:59.000Z

197

A genome-wide association study of global gene expression  

E-Print Network [OSTI]

map of the effects of polymorphism on gene expression in 400 children from families recruited through descriptors for response to unfolded protein (chaperonins and heat shock proteins), regulation of progression may be mapped with considerable power1,2. As a consequence, our objective was to build a database

Liang, Liming

198

Multi-objective gene-pool optimal mixing evolutionary algorithms  

Science Journals Connector (OSTI)

The recently introduced Gene-pool Optimal Mixing Evolutionary Algorithm (GOMEA), with a lean, but sufficient, linkage model and an efficient variation operator, has been shown to be a robust and efficient methodology for solving single objective (SO) ... Keywords: clustering, linkage tree genetic algorithm, multi-objective optimization, optimal mixing

Ngoc Hoang Luong; Han La Poutr; Peter A.N. Bosman

2014-07-01T23:59:59.000Z

199

RESEARCH ARTICLE Open Access Identification of lignin genes and regulatory  

E-Print Network [OSTI]

RESEARCH ARTICLE Open Access Identification of lignin genes and regulatory sequences involved analysis revealed 18 lignin isoforms for each species. We also identified five contigs homologous to R2R3 wall formation and lignin deposition. We searched the contigs against public microRNA database

200

Duplicated genes evolve independently after polyploid formation in cotton  

E-Print Network [OSTI]

Duplicated genes evolve independently after polyploid formation in cotton Richard C. Cronn to characterize the evolution of homoeologous loci in allopolyploid cotton (Gossypium hirsutum) and in species from organismal history was recovered. In contrast to observations involving repetitive DNAs in cotton

Wendel, Jonathan F.

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Nonlinear estimation in a class of gene transcription process  

Science Journals Connector (OSTI)

In this work the Goodwin model applied to gene transcription is employed as a benchmark system for estimation purposes, considering two dynamic behaviors, monotone decreasing and sustained oscillations, each one under a specific parameter's set. The ... Keywords: Asymptotic convergence, Goodwin model, Model uncertainties, Nonlinear observer, Observability analysis

Ricardo Aguilar-Lpez, M. Isabel Neria-Gonzlez, Rafael Martnez-Guerra, Juan L. Mata-Machuca

2014-01-01T23:59:59.000Z

202

Expression of Early Growth Response Genes in Human Prostate Cancer  

Science Journals Connector (OSTI)

...recent observation of a heterozygous somatic WTI mutation in one PLNR of a patient with Wilms...tumors arise from events at or near the WTI locus with birth weights lower than the...alterations in the tumor suppressor gene WTI. J. Pediatr., 123: 673-678, 1993...

Manal A. Eid; M. Vijay Kumar; Kenneth A. Iczkowski; David G. Bostwick; Donald J. Tindall

1998-06-01T23:59:59.000Z

203

Morphological evolution in land plants: new designs with old genes  

Science Journals Connector (OSTI)

...and of different chlorophyte algae have greatly increased the evolutionary...these are present in chlorophyte algae [77,78]. This indicates...87]. Gene duplication can fuel evolution because a duplicate...are not present in chlorophyte algae [96,97], suggesting that...

2012-01-01T23:59:59.000Z

204

Genome Function and Nuclear Architecture: From Gene Expression to Nanoscience  

E-Print Network [OSTI]

Genome Function and Nuclear Architecture: From Gene Expression to Nanoscience Timothy P. O'Brien,1, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold, and nanoscience to relate genome organization and nuclear archi- tecture with development and disease. Integrating

Langowski, Jörg

205

Evolutionary simulations to detect functional lineage-specific genes  

Science Journals Connector (OSTI)

......Goodman, M. 1999The genomic record of Humankind's evolutionary roots. Am. J. Hum...1996; Yang, 1997, Methods). To this end, we use the sequences of the gene copy...after the humanchimpanzee split). To this end, we performed testdis on the human lineage......

Isabelle Dupanloup; Henrik Kaessmann

2006-08-01T23:59:59.000Z

206

Coordinately Up-Regulated Genes in Ovarian Cancer  

Science Journals Connector (OSTI)

...Furusato M., LiVolsi V. A., Menzin A. W., Liu P. C., Benjamin I., Morgan M. A., King S. A., Rebane B. A., Cardonick...carcinomas. Gene, 238: 375-385, 1999. 21 Wang K., Gan L., Jeffery E., Gayle M., Gown A. M., Skelly M., Nelson P. S...

Colleen D. Hough; Kathleen R. Cho; Alan B. Zonderman; Donald R. Schwartz; and Patrice J. Morin

2001-05-15T23:59:59.000Z

207

Classification and evolution of alpha-amylase genes in plants.  

Science Journals Connector (OSTI)

...which most of the a-amylase genes of rice belong...the grass family. a-Amylase (EC 3.2.1.1...endoglycolytic cleavage of amylose and amylopectin, the principal components...biochemistry of plant a-amylases have been reviewed by...

N Huang; G L Stebbins; R L Rodriguez

1992-01-01T23:59:59.000Z

208

Systematic identification of human mitochondrial disease genes through integrative genomics  

E-Print Network [OSTI]

encoding proteins targeted to this organelle. Elucidation of the molecular basis for these disorders of all 33,860 Ensembl human proteins. The genome-wide false discovery rate was estimated from large gold disorders are due to mutations not in the mitochondrial genome (mtDNA) but rather in the nuclear genes

209

GeneVis: visualization tools for genetic regulatory network dynamics  

Science Journals Connector (OSTI)

GeneVis provides a visual environment for exploring the dynamics of genetic regulatory networks. At present time, genetic regulation is the focus of intensive research worldwide, and computational aids are being called for to help in the research of ... Keywords: biological visualization, focus and context, genetic networks, lenses, multirepresentation, visualization

C. A. H Baker; M. S. T Carpendale; P. Prusinkiewicz; M. G. Surette

2002-10-01T23:59:59.000Z

210

Trends in Antibiotic Resistance Genes Occurrence in the Haihe  

E-Print Network [OSTI]

D P E D R O J . J . A L V A R E Z * , | Tianjin Key Laboratory of Environmental Remediation and antibiotic resistance genes (ARGs) was quantified in water and sediment samples collected from a 72 km leads the world in antibiotic use, about 210 000 tons of antibiotics are produced every year, with 180

Alvarez, Pedro J.

211

A Bayesian Framework for Combining Gene Predictions Vladimir Pavlovic  

E-Print Network [OSTI]

deployed in several highly visible genome analysis projects. Popular gene finding systems include Glimmer systems have been made available to the public. Such projects include the genomes of over thirty microbial of the Drosophila genome and Genscan ([2]) was used for analysis of human chromo- some 22. In addition

212

Human Diversity: Our Genes Tell Where we Live  

E-Print Network [OSTI]

of Human Polymorphism (CEPH) in the framework of the Human Genome Diversity Project initiated by LucaHuman Diversity: Our Genes Tell Where we Live Dispatch Laurent Excoffier A detailed genetic analysis of more than a thousand human subjects clusters them into five groups corresponding to major

Rosenberg, Noah

213

Identification and analysis of bacterial virulence genes in vivo  

Science Journals Connector (OSTI)

...mixed population of mutants. Searches have been carried out by screening...provide the basis for long-term studies into their functions...in the classical sense of the term, many of the S. aureus genes...phate and occurs as cells enter the stationary phase of growth...

2000-01-01T23:59:59.000Z

214

ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY  

E-Print Network [OSTI]

are more related to the kind of cancer than to drug activity patterns. Dependency analysis using Bayesian1 11 ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY CLUSTERING AND BAYESIAN of data produced from up- to-date biological experimental processes needs appropriate data mining

215

Uncorrected Proof Copy Finding Genes by Using Computational Tools 85  

E-Print Network [OSTI]

Uncorrected Proof Copy Finding Genes by Using Computational Tools 85 Job: Plant Functional Genomics;Uncorrected Proof Copy 86 Davuluri and Zhang Job: Plant Functional Genomics--Grotewold Compositor: Nettype Job: Plant Functional Genomics--Grotewold Compositor: Nettype Chapter: Chapter 6 Date: 3/15/2003 Pub

216

MICROFLUIDIC DEVICES FOR GENENTIC ANAYLSIS AND GENE EXPRESSION STUDIES  

E-Print Network [OSTI]

MICROFLUIDIC DEVICES FOR GENENTIC ANAYLSIS AND GENE EXPRESSION STUDIES Thesis by Jian Liu field of microfluidics. His advice has helped me out many times when I was struggling in my research, Ziyang Ma, Emil Kartalov, and many other colleagues. I thank Dr. Jessica Melin and the microfluidic

Quake, Stephen R.

217

POSTER PRESENTATION Open Access Combinatorial RNA interference as a gene  

E-Print Network [OSTI]

and HIV-1 tat/rev and vif sequences were inserted into a lentiviral vector under the control of eitherPOSTER PRESENTATION Open Access Combinatorial RNA interference as a gene therapy strategy for HIV-1 in treating HIV-1 infection, as single short hairpin RNAs (shRNAs) are rapidly rendered ineffective

Paris-Sud XI, Université de

218

Prospective on the potential of imaging gene expression  

SciTech Connect (OSTI)

The feasibility of the non-invasive imaging of gene expression is explored. Calculations of the possibility of the direct imaging of specific messenger RNA with radiolabeled antisense are discussed. In addition, possible mechanism for the amplification of the biological signal to enhance image detection are discussed.

Taylor, Scott E; Budinger, Thomas F.

2000-06-01T23:59:59.000Z

219

From Biophysics to Evolutionary Genetics: Statistical Aspects of Gene Regulation  

E-Print Network [OSTI]

be explained in terms of their gene numbers. If, however, a biological function requires the concerted action histones, chromatin, micro-RNAs etc. become relevant, which are just entering the stage of model building in bioinformatics, with the aim of identifying statistical characteristics of functional loci and of building search

Lässig, Michael

220

Energy Costs Constrain the Evolution of Gene Expression  

E-Print Network [OSTI]

Energy Costs Constrain the Evolution of Gene Expression ANDREAS WAGNER� Department of Biochemistry.) 308B:322� 324, 2007. r 2007 Wiley-Liss, Inc. How to cite this article: Wagner A. 2007. Energy costs of nucleotides and amino acids, as well as their polymerization into RNA and proteins cost energy. Changes

Wagner, Andreas

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Lower Oil Prices: A Reason to Give Thanks GENE EPSTEIN  

E-Print Network [OSTI]

Lower Oil Prices: A Reason to Give Thanks By GENE EPSTEIN Nov. 29, 2014 1:31 a.m. ET I give thanks thanks for an oil price that fell below $70 a barrel Friday, mainly because it bodes well for general early this year ("Here Comes $75 Oil," March 31). Amy Jaffe, executive director of energy

California at Davis, University of

222

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product  

Science Journals Connector (OSTI)

...expression of the Wilms tumor suppressor gene WTI, whose inactivation appears to be a key step...constructs driving luciferase reporter genes and with WTI expression vectors showed that the active WTI gene product represses IGF-IR promoter activity...

H Werner; G G Re; I A Drummond; V P Sukhatme; F J Rauscher; 3rd; D A Sens; A J Garvin; D LeRoith; C T Roberts; Jr

1993-01-01T23:59:59.000Z

223

Comparative analysis of synthetic DNA promoters for high-level gene expression in plants  

Science Journals Connector (OSTI)

Plants survive assimilating multiple environmental stress factors (biotic/abiotic) by adjusting inducible and spatio-temporal expression patterns of responsive genes. In plants, the pattern of gene expression is ...

Dipak Kumar Sahoo; Shayan Sarkar; Sumita Raha; Indu B. Maiti; Nrisingha Dey

2014-10-01T23:59:59.000Z

224

Cloning and sequencing of the alcohol dehydrogenase II gene from Zymomonas mobilis  

DOE Patents [OSTI]

The alcohol dehydrogenase II gene from Zymomonas mobilis has been cloned and sequenced. This gene can be expressed at high levels in other organisms to produce acetaldehyde or to convert acetaldehyde to ethanol.

Ingram, Lonnie O. (Gainesville, FL); Conway, Tyrrell (Gainesville, FL)

1992-01-01T23:59:59.000Z

225

Evolution of Hox gene expression and function and the effect on limb specification in arthropods  

E-Print Network [OSTI]

of the homeotic genes Scr, Antp, Ubx, and abd-A duringof the homeotic gene Scr associated with a crustacean leg-crustacean, Porcelio scaber, SCR protein is detected in the

Hsia, Cheryl Chih-Jui

2007-01-01T23:59:59.000Z

226

Genetic analyses of the Rb and p53 genes in murine development and tumorigenesis  

E-Print Network [OSTI]

The RB and p53 genes play central roles in cell cycle and checkpoint control, apoptosis and many other biological processes. These are central tumor suppressor genes that are each inactivated in many human cancers. Mouse ...

MacPherson, David (David P.)

2005-01-01T23:59:59.000Z

227

E-Print Network 3.0 - adenoviral-mediated gene transfer Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biology and Medicine ; Environmental Sciences and Ecology 11 THE JOURNAL OF GENE MEDICINE RESEARCH ARTICLE J Gene Med 2003; 5: 300310. Summary: . Alvarez RD, Gomez-Navarro J, Wang...

228

E-Print Network 3.0 - adenoviral-mediated mikappabalpha gene...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Health Science Center Collection: Biology and Medicine 9 THE JOURNAL OF GENE MEDICINE RESEARCH ARTICLE J Gene Med 2003; 5: 300310. Summary: . Alvarez RD, Gomez-Navarro J, Wang...

229

E-Print Network 3.0 - acbp gene expression Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

acbp gene expression Search Powered by Explorit Topic List Advanced Search Sample search results for: acbp gene expression Page: << < 1 2 3 4 5 > >> 1 Membrane Charge and Curvature...

230

UFO: an Arabidopsis gene involved in both floral meristem and floral organ development.  

Science Journals Connector (OSTI)

RESEARCH ARTICLES UFO: An Arabidopsis Gene Involved in Both Floral...the role of the UNUSUAL FLORAL ORGANS (UFO) gene in Arabidopsis floral development...characterization of the phenotypes of nine ufo alleles. UFO is required for the proper...

231

Gene identification and analysis: an application of neural network-based information fusion  

SciTech Connect (OSTI)

Identifying genes within large regions of uncharacterized DNA is a difficult undertaking and is currently the focus of many research efforts. We describe a gene localization and modeling system called GRAIL. GRAIL is a multiple sensor-neural network based system. It localizes genes in anonymous DNA sequence by recognizing gene features related to protein-coding slice sites, and then combines the recognized features using a neural network system. Localized coding regions are then optimally parsed into a gene mode. RNA polymerase II promoters can also be predicted. Through years of extensive testing, GRAIL consistently localizes about 90 percent of coding portions of test genes with a false positive rate of about 10 percent. A number of genes for major genetic diseases have been located through the use of GRAIL, and over 1000 research laboratories worldwide use GRAIL on regular bases for localization of genes on their newly sequenced DNA.

Matis, S.; Xu, Y.; Shah, M.B.; Mural, R.J.; Einstein, J.R.; Uberbacher, E.C.

1996-10-01T23:59:59.000Z

232

Expression of the Wilms' tumor suppressor gene WT1 during mouse embryogenesis  

Science Journals Connector (OSTI)

...ifferential Regulation of the Wilms' Tumor Gene, WTI, during Differentiation of Embryonal Carcinoma...pattern of the Wilms' tumor suppressor gene, WTI, during embryonal development suggests a role for the WTI proteins in the differentiation of specific...

RR Rackley; AM Flenniken; NP Kuriyan; PM Kessler; MH Stoler; BR Williams

1993-12-01T23:59:59.000Z

233

'Model your genes the mathematical way'a mathematical biology workshop for secondary school teachers  

Science Journals Connector (OSTI)

......mathematical model for a regulatory network of genes...Brief historical review of biochemistry...Suggested lesson plans M2 Graph theory...to model gene regulatory networks Polynomial...simulation of genetic regulatory systems: a literature review. Journal of......

Ana Margarida Martins; Paola Vera-Licona; Reinhard Laubenbacher

2008-06-01T23:59:59.000Z

234

E-Print Network 3.0 - atrophy gene sma Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of worms mutant for the genes listed (far left) andor carrying... of expression of the cnc-2 reporter gene was unchanged in sma-2- mutant worms treated with sma-4-specific...

235

Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and animals  

DOE Patents [OSTI]

Novel double and triple fusion reporter gene constructs harboring distinct imagable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in living cells and in living animals using distinct imaging technologies.

Gambhir, Sanjiv (Portola Valley, CA); Pritha, Ray (Mountain View, CA)

2011-06-07T23:59:59.000Z

236

E-Print Network 3.0 - a5 gene expression Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Genes September 26, 2008 Summary: the filtering function to the expression matrix. > f1 <- kOverA(5, 200) > ffun <- filterfun(f1) > which... genes that are expressed in more...

237

Virus vector gene inserts are stabilized in the presence of satellite panicum mosaic virus coat protein  

E-Print Network [OSTI]

The coat protein of satellite panicum mosaic virus (SPMV) was used to stabilize viral vector gene inserts in planta. A Potato virus X (PVX) vector carrying the SPMV capsid protein (CP) gene was successfully stabilized through three serial passages...

Everett, Anthany Laurence

2009-05-15T23:59:59.000Z

238

Microbial metatranscriptomics : towards understanding microbial gene expression and regulation in natural habitats  

E-Print Network [OSTI]

Metagenomic research has paved the way for a comprehensive understanding of the microbial gene parts list in nature, but a full understanding of microbial gene expression, regulation, and ecology remains a challenge. In ...

Shi, Yanmei, Ph. D. Massachusetts Institute of Technology

2011-01-01T23:59:59.000Z

239

E-Print Network 3.0 - aurata hemoglobin genes Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Rochester Collection: Biology and Medicine 2 25% chance of a child with sickle cell trait Summary: hemoglobin gene D hemoglobin D gene S A A D A A S AA D DA S...

240

E-Print Network 3.0 - auxin-regulated gene expression Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

regulated gene expression Search Powered by Explorit Topic List Advanced Search Sample search results for: auxin-regulated gene expression Page: << < 1 2 3 4 5 > >> 1 Funct Integr...

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

E-Print Network 3.0 - amplified rrna gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: number 54, overexpressing rRNA from an inducible promoter 66, deleting the fis gene 20,67 (see... response specifically associated with changes in rRNA gene dosage...

242

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system  

E-Print Network [OSTI]

The ability to artificially control transcription is essential both to the study of gene function and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA-guided double-stranded DNA nuclease ...

Zhang, Feng

243

Evolution of a Core Gene Network for Skeletogenesis in Jochen Hecht1,2  

E-Print Network [OSTI]

Evolution of a Core Gene Network for Skeletogenesis in Chordates Jochen Hecht1,2 , Sigmar Stricker2: Hecht J, Stricker S, Wiecha U, Stiege A, Panopoulou G, et al (2008) Evolution of a Core Gene Network

Max-Planck-Institut für molekulare Genetik

244

E-Print Network 3.0 - angiogenic factor genes Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

GENE3227X HSA272195 centaurin-alpha 2 protein... GENE6192X SPINT2 serine protease inhibitor, Kunitz type, 2 ... Source: Leng, Chenlei - Department of Statistics and Applied...

245

Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity  

E-Print Network [OSTI]

Filarial nematodes are metazoan parasites with genome sizes of > 100 million base pairs, probably encoding 15 000-20 000 genes. Within this considerable gene complement, it seems likely that filariae have evolved ...

Maizels, Rick; Blaxter, Mark; Scott, Alan

2001-01-01T23:59:59.000Z

246

Regulation of HIV-1 Gene Expression by the Transactivator Protein Tat  

Science Journals Connector (OSTI)

The regulation of HIV-1 gene expression is an area of intense investigation. Like all retroviruses, HIV-1 integrates into cellular DNA, and its gene expression is dependent on host cell transcription factors a...

R. B. Gaynor

1995-01-01T23:59:59.000Z

247

Global depression in gene expression as a response to rapid thermal changes in vent mussels  

Science Journals Connector (OSTI)

...potential relationship between natural genetic variation, stress...attributable to specific gene cascades that can be up- or downregulated...Massive emissions of toxic gas in the Atlantic. Nature 415...explore a relationship between natural genetic variation, gene expression...

2009-01-01T23:59:59.000Z

248

Cell Culture Processes for the Production of Viral Vectors for Gene Therapy Purposes  

Science Journals Connector (OSTI)

Gene therapy is a promising technology for the treatment of several acquired and inherited diseases. However, for gene therapy to be a commercial and clinical success, scalable cell culture processes must be i...

James N. Warnock; Otto-Wilhelm Merten; Mohamed Al-Rubeai

2006-03-01T23:59:59.000Z

249

TABASCO: A single molecule, base-pair resolved gene expression simulator  

E-Print Network [OSTI]

Background Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavior. Given our current understanding of gene ...

Kosuri, Sriram

250

Effects of Dietary Energy Restriction on Gene Regulation in Mammary Epithelial Cells  

Science Journals Connector (OSTI)

...Article Prevention Effects of Dietary Energy Restriction on Gene Regulation in Mammary...study was to determine whether dietary energy restriction (DER) affects the pattern of gene expression in three interrelated energy metabolism pathways: glycolysis, gluconeogenesis...

Zongjian Zhu; Weiqin Jiang; John N. McGinley; Jennifer M. Price; Bifeng Gao; Henry J. Thompson

2007-12-15T23:59:59.000Z

251

Inferring gene regulatory networks from gene expression data by path consistency algorithm based on conditional mutual information  

Science Journals Connector (OSTI)

......clique graph of all genes). Set L=1. Step-1: L=L+1...If I max (i, j|K)theta, set G(i, j)=0. Return to Step-1...network in Yeast genomes. We set the threshold value 0.1 of...and PCA-PCC, our method can cover non-linear relations between......

Xiujun Zhang; Xing-Ming Zhao; Kun He; Le Lu; Yongwei Cao; Jingdong Liu; Jin-Kao Hao; Zhi-Ping Liu; Luonan Chen

2012-01-01T23:59:59.000Z

252

Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and  

E-Print Network [OSTI]

, with software that retrieves, consolidates, searches, and displays human genome information, has enjoyed. These include the Unified Database (UDB) (http://bioinfo.weizmann.ac.il/udb) for human genome mapping, the human://bioinfo.weizmann.ac.il/ cards/, an automated, integrated database of human genes, genomic maps, proteins, and diseases

Groner, Yoram

253

Completion of the gene coding assignments of SA11 rotavirus: gene products of segments 7, 8, and 9.  

Science Journals Connector (OSTI)

...individual translation in vitro. Segment 7 codes for p31 (NS2), segment 8 codes for p33 (NS1), and the segment 9 gene product...individual translation in vitro. Segment 7 codes for p31 (NS2), segment 8 codes for p33 (NS1), and the...

P Kantharidis; M L Dyall-Smith; I H Holmes

1983-10-01T23:59:59.000Z

254

A portal to gene-centered information from different sources http://www.ncbi.nlm.nih.gov/gene/  

E-Print Network [OSTI]

.nlm.nih.gov/feed/rss.cgi?ChanKey=genenews Searching Gene Searching is as simple as entering a set of query terms and clicking the Search button (A). The search interface auto- matically flags and corrects the misspelling in the input term (B). Selecting Details" portlet (D) in the right column displays the actual terms used in the search. Retrieved records

Levin, Judith G.

255

Tissue-Specific Gene Silencing Mediated by a Naturally Occurring Chalcone Synthase Gene Cluster in Glycine max  

Science Journals Connector (OSTI)

...3.5 mM MgCl2, and 0.025 units/muL of AmpliTaq Gold DNA polymerase...deoxynucleotide triphosphate, 2.5 units of Taq polymerase (Invitrogen...to another gene for a house-keeping isoform. Plant J. 13, 267-273...transmitted by grafting from silenced stocks to non-silenced scions. EMBO...

Jigyasa H. Tuteja; Steven J. Clough; Wan-Ching Chan; Lila O. Vodkin

256

Sequencing of rhesus macaque Y chromosome clarifies origins and evolution of the DAZ (Deleted in AZoospermia) genes  

E-Print Network [OSTI]

Studies of Y chromosome evolution often emphasize gene loss, but this loss has been counterbalanced by addition of new genes. The DAZ genes, which are critical to human spermatogenesis, were acquired by the Y chromosome ...

Hughes, Jennifer F.

257

E-Print Network 3.0 - anti-aging gene klotho Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

chemical entities... Gene regulatory networks Inferred from: - protein interaction networks - micro-array data - other... 's Signaling pathwas: rarer reactants,...

258

Systematic analysis of gene expression in human brains before and after death  

E-Print Network [OSTI]

substantially Table 2 Functional analysis of gene expression differences between autopsy and resection samples GO ID Term Expressed genes Significant differences* Change p value Conservation p value GO:0006412 Protein biosynthesis 462 101 (37/64) 0.001 0.999 GO... functional processes. Genes involved in rather basic functions, such as RNA processing, protein bio- synthesis and transport, organelle organization and biogen- esis, the ubiquitin cycle, and DNA repair (Table 1) are over- represented among genes differently...

Franz, Henriette; Ullmann, Claudia; Becker, Albert; Ryan, Margaret; Bahn, Sabine; Arendt, Thomas; Simon, Matthias; Paabo, Svante; Khaitovich, Philipp

2005-12-30T23:59:59.000Z

259

Automated Eukaryotic Gene Structure Annotation Using EVidenceModeler and the Program to Assemble Spliced Alignments  

SciTech Connect (OSTI)

EVidenceModeler (EVM) is presented as an automated eukaryotic gene structure annotation tool that reports eukaryotic gene structures as a weighted consensus of all available evidence. EVM, when combined with the Program to Assemble Spliced Alignments (PASA), yields a comprehensive, configurable annotation system that predicts protein-coding genes and alternatively spliced isoforms. Our experiments on both rice and human genome sequences demonstrate that EVM produces automated gene structure annotation approaching the quality of manual curation.

Haas, B J; Salzberg, S L; Zhu, W; Pertea, M; Allen, J E; Orvis, J; White, O; Buell, C R; Wortman, J R

2007-12-10T23:59:59.000Z

260

Orthogonal Control of Endogenous Gene Expression in Mammalian Cells Using Synthetic Ligands  

E-Print Network [OSTI]

ARTICLE Orthogonal Control of Endogenous Gene Expression in Mammalian Cells Using Synthetic Ligands South Mathews Avenue, Urbana, Illinois 61801 ABSTRACT: Gene switches have wide utility in synthetic-finger DNA binding domain (DBD). Our gene switch is specifically and reversibly con- trolled by 4

Zhao, Huimin

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Zinc finger point mutations within the WT1 gene in Wilms tumor patients  

Science Journals Connector (OSTI)

...Genetics Zinc finger point mutations within the WTI gene in Wilms tumor patients (zinc finger...1992 ABSTRACT A proposed Wilms tumor gene, WTI, which encodes a zinc ringer protein...amino acid change. To our knowl- edge, a WTI gene missense mutation has not been detected...

M H Little; J Prosser; A Condie; P J Smith; V Van Heyningen; N D Hastie

1992-01-01T23:59:59.000Z

262

Patterns of Gene-Specific and Total Transcriptional Activity during the Plasmodium falciparum Intraerythrocytic Developmental Cycle  

Science Journals Connector (OSTI)

...during the IDC, we performed nuclear run-on on whole-transcriptome...genes from gene-specific nuclear run-on hybridization data...activity and RNA stability datasets were available, we found that...points, to gene-specific nuclear run-on data from those time...

Jennifer S. Sims; Kevin T. Militello; Peter A. Sims; Vishal P. Patel; Jacob M. Kasper; Dyann F. Wirth

2009-01-16T23:59:59.000Z

263

Expression profiling of hypothetical genes in Desulfovibrio vulgaris leads to improved functional annotation  

SciTech Connect (OSTI)

Hypothetical and conserved hypothetical genes account for>30percent of sequenced bacterial genomes. For the sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough, 347 of the 3634 genes were annotated as conserved hypothetical (9.5percent) along with 887 hypothetical genes (24.4percent). Given the large fraction of the genome, it is plausible that some of these genes serve critical cellular roles. The study goals were to determine which genes were expressed and provide a more functionally based annotation. To accomplish this, expression profiles of 1234 hypothetical and conserved genes were used from transcriptomic datasets of 11 environmental stresses, complemented with shotgun LC-MS/MS and AMT tag proteomic data. Genes were divided into putatively polycistronic operons and those predicted to be monocistronic, then classified by basal expression levels and grouped according to changes in expression for one or multiple stresses. 1212 of these genes were transcribed with 786 producing detectable proteins. There was no evidence for expression of 17 predicted genes. Except for the latter, monocistronic gene annotation was expanded using the above criteria along with matching Clusters of Orthologous Groups. Polycistronic genes were annotated in the same manner with inferences from their proximity to more confidently annotated genes. Two targeted deletion mutants were used as test cases to determine the relevance of the inferred functional annotations.

Elias, Dwayne A.; Mukhopadhyay, Aindrila; Joachimiak, Marcin P.; Drury, Elliott C.; Redding, Alyssa M.; Yen, Huei-Che B.; Fields, Matthew W.; Hazen, Terry C.; Arkin, Adam P.; Keasling, Jay D.; Wall, Judy D.

2008-10-27T23:59:59.000Z

264

No Gene-Specific Optimization of Mutation Rate in Escherichia coli  

E-Print Network [OSTI]

selection, E. coli. Because mutation is the ultimate source of genetic variation and evolution, accurately to approximately 0.3 among E. coli genes (Martincorena and Luscombe 2013). Assuming that Áf between genes of multiple genes with similar fractions of deleterious mutations. Analyzing published genome sequences of E

Zhang, Jianzhi

265

Distinguishing protein-coding and noncoding genes in the human genome  

E-Print Network [OSTI]

) Although the Human Genome Project was completed 4 years ago, the catalog of human protein-coding genesDistinguishing protein-coding and noncoding genes in the human genome Michele Clamp* , Ben Fry An accurate catalog of the protein-coding genes encoded in the human genome is fundamental to the study

Kellis, Manolis

266

Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes.  

Science Journals Connector (OSTI)

...promoter-initiated RNAs. Spliced RNA from the TP gene was detected in all four subjects. Expression of the TP gene was restricted to TP1 promoter-initiated...situ and suggesting a central role for the TP gene in the latency of EBV. Epstein-Barr...

L Qu; D T Rowe

1992-06-01T23:59:59.000Z

267

Synonymous and Nonsynonymous Rate Variation in Nuclear Genes Ziheng Yang,1,2,  

E-Print Network [OSTI]

substitutions in nuclear genes of mammals to test the neutral theory. The index of dispersion is the varianceSynonymous and Nonsynonymous Rate Variation in Nuclear Genes of Mammals Ziheng Yang,1,2, * Rasmus to estimate the synonymous and nonsynonymous substi- tution rates in 48 nuclear genes from primates, artiodac

Nielsen, Rasmus

268

Shotgun DNA microarrays and stage-specic gene expression in Plasmodium falciparum malaria  

E-Print Network [OSTI]

, labour intensive, and expensive to propagate. Second, the experimental power of transfection technology stages can be transfected, gene disruptions are only possible for non-essential genes, as this part there is no negative selection system. Transfection ef®- ciencies in P. falciparum are so poor that no gene function

269

Microtargeted gene silencing and ectopic expression in live embryos using biolistic delivery with a pneumatic capillary gun  

E-Print Network [OSTI]

a Pneumatic Capillary Gun Orit Shefi, 1 Claire Simonnet, 2medicinalis; netrin; gene gun Introduction Modulating geneby the current design of gene guns used for particle

Shefi, Orit; Simonnet, Claire; Baker, Michael W; Glass, James R; Macagno, Eduardo R; Groisman, Alex

2006-01-01T23:59:59.000Z

270

E-Print Network 3.0 - ahr-regulated genes cyp1a1 Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

as the "Ah gene battery"187,188 . The AHR regulates gene... androstane receptor CNC: cap'n'collar ... Source: Hahn, Mark E. - Biology Department, Woods Hole Oceanographic...

271

Manipulating Genes with Hidden TALENs | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A New Discovery Answers an Old Question A New Discovery Answers an Old Question Peering into the Interfaces of Nanoscale Polymeric Materials Ironing Out the Details of the Earth's Core Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Manipulating Genes with Hidden TALENs FEBRUARY 10, 2012 Bookmark and Share X-ray studies carried out at APS and computer modeling of the data reveal how TALEN intimately winds itself into the major groove of target DNA to form a protein-DNA complex just 60 Å x 60 Å x 90 Å. From Amanda Nga-Sze Mak et al., Science 335(6069), 716 (10 February, 2012). A better understanding of gene function in model plant and animal systems could be used to develop useful traits in livestock and crop plants, and

272

Plant isoflavone and isoflavanone O-methyltransferase genes  

DOE Patents [OSTI]

The invention provides enzymes that encode O-methyltransferases (OMTs) from Medicago truncatula that allow modification to plant (iso)flavonoid biosynthetic pathways. In certain aspects of the invention, the genes encoding these enzymes are provided. The invention therefore allows the modification of plants for isoflavonoid content. Transgenic plants comprising such enzymes are also provided, as well as methods for improving disease resistance in plants. Methods for producing food and nutraceuticals, and the resulting compositions, are also provided.

Broeckling, Bettina E.; Liu, Chang-Jun; Dixon, Richard A.

2014-08-19T23:59:59.000Z

273

Pnp gene modification for improved xylose utilization in Zymomonas  

DOE Patents [OSTI]

The endogenous pnp gene encoding polynucleotide phosphorylase in the Zymomonas genome was identified as a target for modification to provide improved xylose utilizing cells for ethanol production. The cells are in addition genetically modified to have increased expression of ribose-5-phosphate isomerase (RPI) activity, as compared to cells without this genetic modification, and are not limited in xylose isomerase activity in the absence of the pnp modification.

Caimi, Perry G G; Qi, Min; Tao, Luan; Viitanen, Paul V; Yang, Jianjun

2014-12-16T23:59:59.000Z

274

Compositions and methods for detecting gene rearrangements and translocations  

DOE Patents [OSTI]

Disclosed is a series of nucleic acid probes for use in diagnosing and monitoring certain types of leukemia using, e.g., Southern and Northern blot analyses and fluorescence in situ hybridization (FISH). These probes detect rearrangements, such as translocations involving chromosome band 11q23 with other chromosomes bands, including 4q21, 6q27, 9p22, 19p13.3, in both dividing leukemic cells and interphase nuclei. The breakpoints in all such translocations are clustered within an 8.3 kb BamHI genomic region of the MLL gene. A novel 0.7 kb BamH1 cDNA fragment derived from this gene detects rearrangements on Southern blot analysis with a single BamHI restriction digest in all patients with the common 11q23 translocations and in patients with other 11q23 anomalies. Northern blot analyses are presented demonstrating that the MLL gene has multiple transcripts and that transcript size differentiates leukemic cells from normal cells. Also disclosed are MLL fusion proteins, MLL protein domains and anti-MLL antibodies.

Rowley, Janet D. (Chicago, IL); Diaz, Manuel O. (Chicago, IL)

2000-01-01T23:59:59.000Z

275

Probing cell-free gene expression noise in femtoliter volumes  

SciTech Connect (OSTI)

Cell-free systems offer a simplified and flexible context that enables important biological reactions while removing complicating factors such as fitness, division, and mutation that are associated with living cells. However, cell-free expression in unconfined spaces is missing important elements of expression in living cells. In particular, the small volume of living cells can give rise to significant stochastic effects, which are negligible in bulk cell-free reactions. Here, we confine cell-free gene expression reactions to cell relevant 20 fL volumes (between the volumes of E. coli and S. cerevisiae), in polydimethylsiloxane (PDMS) containers. We demonstrate that expression efficiency varies widely at this volume, and we analyze gene expression noise. Noise analysis reveals signatures of translational bursting while noise dynamics suggest that overall cell-free expression is limited by a diminishing translation rate. In addition to offering a unique approach to understanding noise in gene circuits, our work contributes to a deeper understanding of the biophysical properties of cell-free expression systems, thus aiding efforts to harness cell-free systems for synthetic biology applications.

Karig, David K [ORNL; Jung, Seung-Yong [ORNL; Srijanto, Bernadeta R [ORNL; Collier, Pat [ORNL; Simpson, Michael L [ORNL

2013-01-01T23:59:59.000Z

276

Ayuda:Imágenes | Open Energy Information  

Open Energy Info (EERE)

Imágenes Imágenes Jump to: navigation, search Esta página trata en detalle la sintaxis de la imagen al momento de editar una página wiki. Usted o algún otro usuario deberá comúnmente cargar una imagen antes de que esta sea visible en la página. Contents 1 Sintaxis 2 Formato 3 Alineación 3.1 Alineación vertical 4 Tamaño y cuadro 5 Detener del movimiento de texto 6 Galería de Imágenes 6.1 Parámetros 7 Enlaces 7.1 Enlace a la página de descripción 7.2 Enlazar directamente al archivo 8 Requisitos 9 Archivos en otras páginas web Sintaxis La sintaxis necesaria para mostrar una imagen: [[Image:{nombre_archivo}|{opciones}]] Donde las opciones que se señalan a continuación, separadas por barras verticales, pueden oscilar entre cero o más: border, frame, thumb, o frameless: Determina el proceso de formato

277

MicroSyn: A user friendly tool for detection of microsynteny in a gene family  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

O O F T W A R E Open Access MicroSyn: A user friendly tool for detection of microsynteny in a gene family Bin Cai 1,2 , Xiaohan Yang 3,4 , Gerald A Tuskan 3,4 and Zong-Ming Cheng 1,2,4* Abstract Background: The traditional phylogeny analysis within gene family is mainly based on DNA or amino acid sequence homologies. However, these phylogenetic tree analyses are not suitable for those "non-traditional" gene families like microRNA with very short sequences. For the normal protein-coding gene families, low bootstrap values are frequently encountered in some nodes, suggesting low confidence or likely inappropriateness of placement of those members in those nodes. Results: We introduce MicroSyn software as a means of detecting microsynteny in adjacent genomic regions surrounding genes in gene families. MicroSyn searches for conserved, flanking colinear homologous gene

278

Process and genes for expression and overexpression of active [FeFe] hydrogenases  

DOE Patents [OSTI]

A process for expression of active [FeFe]-hydrogenase in a host organism that does not contain either the structural gene(s) for [FeFe]-hydrogenases and/or homologues for the maturation genes HydE, HydF and HyG, comprising: cloning the structural hydrogenase gene(s) and/or the maturation genes HydE, HydF and HydG from an organisms that contains these genes into expression plasmids; transferring the plasmids into an organism that lacks a native [FeFe]-hydrogenase or that has a disrupted [FeFe]-hydrogenase and culturing it aerobically; and inducing anaerobiosis to provide [FeFe] hydrogenase biosynthesis and H?2#191 production.

Seibert, Michael; King, Paul W; Ghirardi, Maria Lucia; Posewitz, Matthew C; Smolinski, Sharon L

2014-09-16T23:59:59.000Z

279

Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells  

SciTech Connect (OSTI)

Highlights: ? We tried to identify targets of synovial sarcoma (SS)-associated SYTSSX fusion gene. ? We established pluripotent stem cell (PSC) lines with inducible SYTSSX gene. ? SYTSSX responsive genes were identified by the induction of SYTSSX in PSC. ? SS-related genes were selected from database by in silico analyses. ? 51 genes were finally identified among SS-related genes as targets of SYTSSX in PSC. -- Abstract: Synovial sarcoma (SS) is a malignant soft tissue tumor harboring chromosomal translocation t(X; 18)(p11.2; q11.2), which produces SS-specific fusion gene, SYTSSX. Although precise function of SYTSSX remains to be investigated, accumulating evidences suggest its role in gene regulation via epigenetic mechanisms, and the product of SYTSSX target genes may serve as biomarkers of SS. Lack of knowledge about the cell-of-origin of SS, however, has placed obstacle in the way of target identification. Here we report a novel approach to identify SYTSSX2 target genes using human pluripotent stem cells (hPSCs) containing a doxycycline-inducible SYTSSX2 gene. SYTSSX2 was efficiently induced both at mRNA and protein levels within three hours after doxycycline administration, while no morphological change of hPSCs was observed until 24 h. Serial microarray analyses identified genes of which the expression level changed more than twofold within 24 h. Surprisingly, the majority (297/312, 95.2%) were up-regulated genes and a result inconsistent with the current concept of SYTSSX as a transcriptional repressor. Comparing these genes with SS-related genes which were selected by a series of in silico analyses, 49 and 2 genes were finally identified as candidates of up- and down-regulated target of SYTSSX, respectively. Association of these genes with SYTSSX in SS cells was confirmed by knockdown experiments. Expression profiles of SS-related genes in hPSCs and human mesenchymal stem cells (hMSCs) were strikingly different in response to the induction of SYTSSX, and more than half of SYTSSX target genes in hPSCs were not induced in hMSCs. These results suggest the importance of cellular context for correct understanding of SYTSSX function, and demonstrated how our new system will help to overcome this issue.

Hayakawa, Kazuo [Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto (Japan) [Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto (Japan); Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto (Japan); Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya (Japan); Ikeya, Makoto [Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto (Japan)] [Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto (Japan); Fukuta, Makoto [Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto (Japan) [Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto (Japan); Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto (Japan); Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya (Japan); Woltjen, Knut [Department of Reprogramming Sciences, Center for iPS Cell Research and Application, Kyoto University, Kyoto (Japan)] [Department of Reprogramming Sciences, Center for iPS Cell Research and Application, Kyoto University, Kyoto (Japan); Tamaki, Sakura; Takahara, Naoko; Kato, Tomohisa; Sato, Shingo [Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto (Japan)] [Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto (Japan); Otsuka, Takanobu [Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya (Japan)] [Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya (Japan); Toguchida, Junya, E-mail: togjun@frontier.kyoto-u.ac.jp [Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto (Japan) [Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto (Japan); Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto (Japan); Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto (Japan)

2013-03-22T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Evaluation of Gene Breed Type and Expression of Feed Efficiency Candidate Genes, and Their Associations with Carcass Traits in F2 Nellore-Angus Steers  

E-Print Network [OSTI]

determined for 4 candidate genes of feed efficiency: insulin like growth factor-1 (IGF1), leptin (LEP), neuropeptide-Y (NPY) and ghrelin (GHRL). Gene breed types were represented as AA, AN, NA, and NN where A and N denote Angus and Nellore, respectively...

Cardin, Jessica Marie

2011-10-21T23:59:59.000Z

282

Effects of alien and intraspecies cytoplasms on manifestation of nuclear genes for wheat resistance to brown rust: II. Specificity of cytoplasm influence on different Lr genes  

SciTech Connect (OSTI)

Specificity of expression of the major nuclear genes Lr to two brown rust clones in hybrids with the same maternal cytoplasm was analyzed. It was evaluated by a resistant: susceptible ratio in the F{sub 2}. Reciprocal hybrids were obtained from the cross between the progeny of homozygous susceptible plants of the cultivar Penjamo 62 and its alloplasmatic lines carrying cytoplasms of Triticum dicoccoides var. fulvovillosum, Aegilops squarrosa var. typical, Agropyron trichophorum, and isogenic lines of the cultivar Thatcher (Th) with the Lr1, Lr9, Lr15, and Lr19 genes. It was shown that the effect of the Lr1 gene in the cytoplasm of cultivar Thatcher and in eu-, and alloplasmatic forms of Penjamo 62 was less expressed than that of other Lr genes. Cytoplasm of the alloplasmatic line (dicoccoides)-Penjamo 62 was the only exception: in the F{sub 2}, hybrids with Th (Lr1) had a higher yield of resistant forms than those with Th (Lr15). In the hybrid combinations studied, expression and/or transmission of the Lr19 gene was more significant than that of other genes. This gene had no advantages over Lr15 and Lr19 only in cytoplasm of the alloplasmatic line (squarrosa)-Penjamo 62. In certain hybrid cytoplasms, the display of the Lr1, Lr15, and Lr19 genes, in contrast to Lr9, varied with the virulence of the pathogen clones. 15 refs., 5 tabs.

Voluevich, E.A.; Buloichik, A.A.; Palilova, A.N. [Institute of Genetics and Cytology, Minsk (Belarus)

1995-04-01T23:59:59.000Z

283

Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes  

Science Journals Connector (OSTI)

...sequence and a phylogenetic analysis of the smallest influenza gene segment, which codes for the NS1 protein and the nuclear export protein (NEP, previously NS2). To begin to understand the role NS gene products, NS1 and NEP, may have played...

Christopher F. Basler; Ann H. Reid; Jody K. Dybing; Thomas A. Janczewski; Thomas G. Fanning; Hongyong Zheng; Mirella Salvatore; Michael L. Perdue; David E. Swayne; Adolfo Garca-Sastre; Peter Palese; Jeffery K. Taubenberger

2001-01-01T23:59:59.000Z

284

[CANCER RESEARCH 64, 53905397, August 1, 2004] Effective Gene-Viral Therapy for Telomerase-Positive Cancers by Selective  

E-Print Network [OSTI]

-Positive Cancers by Selective Replicative-Competent Adenovirus Combining with Endostatin Gene Qi Zhang,1 Mingming

Tian, Weidong

285

How do insect nuclear and mitochondrial gene substitution patterns differ? Insights from Bayesian analyses of combined datasets  

E-Print Network [OSTI]

3 June 2003 Abstract We analyzed 12 combined mitochondrial and nuclear gene datasets in seven orders systematists should increasingly focus on nuclear rather than mitochondrial gene datasets because nuclear genesHow do insect nuclear and mitochondrial gene substitution patterns differ? Insights from Bayesian

Danforth, Bryan Nicholas

286

Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat  

SciTech Connect (OSTI)

Acquired immunodeficiency syndrome patients are frequently coinfected with Epstein-Barr virus (EBV). In this report, the authors demonstrate that an EBV immediate-early gene product, BamHI MLF1, stimulates expression of the bacterial chloramphenicol acetyltransferase (CAT) gene linked to the human immunodeficiency virus (HIV) promoter. The HIV promoter sequences necessary for trans-activation by EBV do not include the tat-responsive sequences. In addition, in contrast to the other herpesvirus trans-activators previously studied, the EBV BamHI MLF1 gene product appears to function in part by a posttranscriptional mechanism, since it increases pHIV-CAT protein activity more than it increases HIV-CAT mRNA. This ability of an EBV gene product to activate HIV gene expression may have biologic consequences in persons coinfected with both viruses.

Kenney, S.; Kamine, J.; Markovitz, D.; Fenrick, R.; Pagano, J.

1988-03-01T23:59:59.000Z

287

Gene selection using rough set based on neighborhood for the analysis of plant stress response  

Science Journals Connector (OSTI)

Abstract Gene selection and sample classification based on gene expression data are important research trends in bioinformatics. It is very difficult to select significant genes closely related to classification because of the high dimension and small sample size of gene expression data. Rough set based on neighborhood has been successfully applied to gene selection, as it selects attributes without redundancy and deals with numerical attributes directly. Construction of neighborhoods, approximation operators and attribute reduction algorithm are three key components in this gene selection approach. In this study, a novel neighborhood named intersection neighborhood for numerical data was defined. The performances of two kinds of approximation operators were compared on gene expression data. A significant gene selection algorithm, which was applied to the analysis of plant stress response, was proposed by using positive region and gene ranking, and then this algorithm with thresholds optimization for intersection neighborhood was extended. The performance of the proposed algorithm, along with a comparison with other related methods, classical algorithms and rough set methods, was analyzed. The results of experiments on four data sets showed that intersection neighborhood was more flexible to adapt to the data with various structure, and approximation operator based on elementary set was more suitable for this application than that based on element. That was to say that the proposed algorithms were effective, as they could select significant gene subsets without redundancy and achieve high classification accuracy.

Jun Meng; Jing Zhang; Rui Li; Yushi Luan

2014-01-01T23:59:59.000Z

288

Green genes: bioinformatics and systems biology innovations drive algal biotechnology  

E-Print Network [OSTI]

for microalgae 4 The nuclear genome of the model green alga Chlamydomonas reinhardtii, sequenced in 2007 5 [1], is approximately 120 Mb and encodes ~15,000 genes. Although C. reinhardtii is commonly 6 used as a reference for the annotation of other microalgae... facilitation of 5 transgene expression comes from the use of 2A peptides [78], which cause self-cleavage to 6 release individual domains from a fusion protein. They thus provide the capacity for operon-7 like transgene expression within the nucleus. Marker...

Reijnders, Maarten J. M. F.; van Heck, Ruben; Lam, Carolyn M. C.; Scaife, Mark A.; Martins dos Santos, Vitor A. P.; Smith, Alison G.; Schaap, Peter J.

2014-10-21T23:59:59.000Z

289

Genome-wide discovery of missing genes in biological pathways of prokaryotes  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Genome-wide Genome-wide discovery of missing genes in biological pathways of prokaryotes Yong Chen 1,3,4,5 , Fenglou Mao 1,2 , Guojun Li 1,3 , Ying Xu 1,2,6* From The Ninth Asia Pacific Bioinformatics Conference (APBC 2011) Incheon, Korea. 11-14 January 2011 Abstract Background: Reconstruction of biological pathways is typically done through mapping well-characterized pathways of model organisms to a target genome, through orthologous gene mapping. A limitation of such pathway-mapping approaches is that the mapped pathway models are constrained by the composition of the template pathways, e.g., some genes in a target pathway may not have corresponding genes in the template pathways, the so-called "missing gene" problem. Methods: We present a novel pathway-expansion method for identifying additional genes that are possibly involved in a target pathway after pathway mapping,

290

Nucleotide sequence of the Dpn II DNA methylase gene of Streptococcus pneumoniae and its relationship to the dam gene of Escherichia coli  

SciTech Connect (OSTI)

The structural gene (dpnM) for the Dpn II DNA methylase of Streptococcus pneumoniae, which is part of the Dpn II restriction system and methylates adenine in the sequence 5'-G-A-T-C-3', was identified by subcloning fragments of a chromosomal segment from a Dpn II-producing strain in an S. pneumoniae host/vector cloning system and demonstrating function of the gene also in Bacillus subtilis. Determination of the nucleotide sequence of the gene and adjacent DNA indicates that it encodes a polypeptide of 32,903 daltons. A putative promoter for transcription of the gene lies within a hundred nucleotides of the polypeptide start codon. Comparison of the coding sequence to that of the dam gene of Escherichia coli, which encodes a similar methylase, revealed 30% of the amino acid residues in the two enzymes to be identical. This homology presumably reflects a common origin of the two genes prior to the divergence of Gram-positive and Gram-negative bacteria. It is suggested that the restriction function of the gene is primitive, and that the homologous restriction system in E. coli has evolved to play an accessory role in heteroduplex DNA base mismatch repair.

Mannarelli, B.M.; Balganesh, T.S.; Greenberg, B.; Springhorn, S.S.; Lacks, S.A.

1985-07-01T23:59:59.000Z

291

Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1? gene expression in pancreatic islet ?-cells  

SciTech Connect (OSTI)

Highlights: Arnt mRNA expressed in a circadian manner in mouse pancreatic islets. Expressions of Dbp and Arnt damped in the islets of a diabetic model mouse. DBP and E4BP4 regulate Arnt promoter activity by direct binding. Arnt may have a role in connecting circadian rhythm and metabolism. -- Abstract: Aryl hydrocarbon receptor nuclear translocator (ARNT)/hypoxia inducible factor-1? (HIF-1?) has emerged as a potential determinant of pancreatic ?-cell dysfunction and type 2 diabetes in humans. An 82% reduction in Arnt expression was observed in islets from type 2 diabetic donors as compared to non-diabetic donors. However, few regulators of Arnt expression have been identified. Meanwhile, disruption of the clock components CLOCK and BMAL1 is known to result in hypoinsulinemia and diabetes, but the molecular details remain unclear. In this study, we identified a novel molecular connection between Arnt and two clock-controlled output genes, albumin D-element binding protein (Dbp) and E4 binding protein 4 (E4bp4). By conducting gene expression studies using the islets of Wfs1{sup ?/?} A{sup y}/a mice that develop severe diabetes due to ?-cell apoptosis, we demonstrated clock-related gene expressions to be altered in the diabetic mice. Dbp mRNA decreased by 50%, E4bp4 mRNA increased by 50%, and Arnt mRNA decreased by 30% at Zeitgever Time (ZT) 12. Mouse pancreatic islets exhibited oscillations of clock gene expressions. E4BP4, a D-box negative regulator, oscillated anti-phase to DBP, a D-box positive regulator. We also found low-amplitude circadian expression of Arnt mRNA, which peaked at ZT4. Over-expression of DBP raised both mRNA and protein levels of ARNT in HEK293 and MIN6 cell lines. Arnt promoter-driven luciferase reporter assay in MIN6 cells revealed that DBP increased Arnt promoter activity by 2.5-fold and that E4BP4 competitively inhibited its activation. In addition, on ChIP assay, DBP and E4BP4 directly bound to D-box elements within the Arnt promoter in MIN6 cells. These results suggest that in mouse pancreatic islets mRNA expression of Arnt fluctuates significantly in a circadian manner and that the down-regulation of Dbp and up-regulation E4bp4 contribute to direct suppression of Arnt expression in diabetes.

Nakabayashi, Hiroko; Ohta, Yasuharu, E-mail: yohta@yamaguchi-u.ac.jp; Yamamoto, Masayoshi; Susuki, Yosuke; Taguchi, Akihiko; Tanabe, Katsuya; Kondo, Manabu; Hatanaka, Masayuki; Nagao, Yuko; Tanizawa, Yukio, E-mail: tanizawa@yamaguchi-u.ac.jp

2013-05-03T23:59:59.000Z

292

Determination of the linkage relationships and the gene-centromere genetic distances for endopeptidase structural genes in hexaploid wheat  

E-Print Network [OSTI]

357307 contribute to band 4 Calculation of gene-centromere genet 'c distance for 7BI. using region I (RI) recombinant progeny Genetic distance bet~~een EP-Bly and Ep-Blz and the frequency of region II (RII) cro. over progeny LIST OF FIGURES... ram Phenot e Total ChrolQo some Co~st. it ut ion 42 43 41 41+telo 42+telo 40+telo and/or not ~f ~1* 8 IU VI IX Chromosome ?BL 42. 17 Centromere ~Ey-El Kp-Blz Chromosome 7AL K -Alz 6. 67 3 90 RII ~E-Alx l0. 67 Figure 8. Linkage...

McMillin, David Edwin

2012-06-07T23:59:59.000Z

293

Recognizing genes and other components of genomic structure  

SciTech Connect (OSTI)

The Aspen Center for Physics (ACP) sponsored a three-week workshop, with 26 scientists participating, from 28 May to 15 June, 1990. The workshop, entitled Recognizing Genes and Other Components of Genomic Structure, focussed on discussion of current needs and future strategies for developing the ability to identify and predict the presence of complex functional units on sequenced, but otherwise uncharacterized, genomic DNA. We addressed the need for computationally-based, automatic tools for synthesizing available data about individual consensus sequences and local compositional patterns into the composite objects (e.g., genes) that are -- as composite entities -- the true object of interest when scanning DNA sequences. The workshop was structured to promote sustained informal contact and exchange of expertise between molecular biologists, computer scientists, and mathematicians. No participant stayed for less than one week, and most attended for two or three weeks. Computers, software, and databases were available for use as electronic blackboards'' and as the basis for collaborative exploration of ideas being discussed and developed at the workshop. 23 refs., 2 tabs.

Burks, C. (Los Alamos National Lab., NM (USA)); Myers, E. (Arizona Univ., Tucson, AZ (USA). Dept. of Computer Science); Stormo, G.D. (Colorado Univ., Boulder, CO (USA). Dept. of Molecular, Cellular and Developmental Biology)

1991-01-01T23:59:59.000Z

294

How do insect nuclear and mitochondrial gene substitution patterns differ? Insights from Bayesian analyses of combined datasets  

Science Journals Connector (OSTI)

We analyzed 12 combined mitochondrial and nuclear gene datasets in seven orders of insects using both equal weights parsimony (to evaluate phylogenetic utility) and Bayesian methods (to investigate substitution patterns). For the Bayesian analyses we used relatively complex models (e.g., general time reversible models with rate variation) that allowed us to quantitatively compare relative rates among genes and codon positions, patterns of rate variation among genes, and substitution patterns within genes. Our analyses indicate that nuclear and mitochondrial genes differ in a number of important ways, some of which are correlated with phylogenetic utility. First and most obviously, nuclear genes generally evolve more slowly than mitochondrial genes (except in one case), making them better markers for deep divergences. Second, nuclear genes showed universally high values of CI and (generally) contribute more to overall tree resolution than mitochondrial genes (as measured by partitioned Bremer support). Third, nuclear genes show more homogeneous patterns of among-site rate variation (higher values of ? than mitochondrial genes). Finally, nuclear genes show more symmetrical transformation rate matrices than mitochondrial genes. The combination of low values of ? and highly asymmetrical transformation rate matrices may explain the overall poor performance of mitochondrial genes when compared to nuclear genes in the same analysis. Our analyses indicate that some parameters are highly correlated. For example, A/T bias was positively and significantly associated with relative rate and CI was positively and significantly associated with ? (the shape of the gamma distribution). These results provide important insights into the substitution patterns that might characterized high quality genes for phylogenetic analysis: high values of ?, unbiased base composition, and symmetrical transformation rate matrices. We argue that insect molecular systematists should increasingly focus on nuclear rather than mitochondrial gene datasets because nuclear genes do not suffer from the same substitutional biases that characterize mitochondrial genes.

Chung-Ping Lin; Bryan N Danforth

2004-01-01T23:59:59.000Z

295

Combining gene expression and interaction network data to improve kidney lesion score prediction  

Science Journals Connector (OSTI)

Current method of diagnosing kidney rejection based on histopathology of renal biopsies in form of lesion scores is error-prone. Researchers use gene expression microarrays in combination of machine learning to build better kidney rejection predictors. However the high dimensionality of data makes this task challenging and compels application of feature selection methods. We present a method for predicting lesions using combination of statistical and biological feature selection methods along with an ensemble learning technique. Results show that combining highly interacting genes (Hub Genes) from protein-protein interaction network with genes selected by squared t-test method brings the most accurate kidney lesion score predictor.

Davoud Moulavi; Mohsen Hajiloo; Jorg Sander; Philip F. Halloran; Russell Greiner

2012-01-01T23:59:59.000Z

296

E-Print Network 3.0 - artificial gene fusion Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: for their usefulness in gene therapy. We investigated thymidine kinase (TK) fusion proteins including the HIV TAT... 1 General Introduction 12;Chapter 1 10 Cancer...

297

E-Print Network 3.0 - autoimmunity susceptibility gene Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

class II haplotypes with 129 unaffected Doberman Pinschers. Three dog-leucocyte antigen (DLA) genes, DLA... hypothyroid disease, other autoimmune dis- eases, cancer and allergic...

298

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents [OSTI]

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2011-10-04T23:59:59.000Z

299

E-Print Network 3.0 - altered ovarian gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: altered ovarian gene Page: << < 1 2 3 4 5 > >> 1 Ovarian cancer is the most lethal cause of death among the gynecological cancers. Conventional...

300

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents [OSTI]

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2008-09-30T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
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301

E-Print Network 3.0 - ancient immunity gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Davis Collection: Environmental Sciences and Ecology 70 Introduction: Molecular Bio-Hacking Department of Bioengineering Summary: of the vertebrate immune system (the RAG gene)...

302

E-Print Network 3.0 - activated human genes Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Indeed, until now, geneticists knew of only 40 such genes... the human genome. The software predicted the existence of 156 ... Source: Hartemink, Alexander - Center for...

303

E-Print Network 3.0 - array-based gene discovery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2001 Summary: 1Mark-A. Krogel, Magdeburg University, Knowledge Discovery and Machine Learning Group KDD Cup 2001... : GeneProtein Function Prediction Using the Multirelational...

304

E-Print Network 3.0 - aldh gene variants Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Physics 48 ProDiGe: PRioritization Of Disease Genes with multitask machine learning from positive and unlabeled examples Summary: variants recover roughly one...

305

E-Print Network 3.0 - approach matching gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

COMMON EVIDENCE NETWORK: AN INTEGRATED APPROACH TO INVESTIGATING GENE RELATIONSHIPS by Alison... of Project: Common Evidence Network: An Integrated Approach to Investigating...

306

E-Print Network 3.0 - analysis reveals genes Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is minor at best. Finally, we tested... to be sufficient to generate the substantial functional redundancy seen among the duplicate genes. This analysis... of a large scale...

307

E-Print Network 3.0 - automated eukaryotic gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

origins. The results... relationships for eukaryotic genes ... Source: Cotton, James - School of Biological and Chemical Sciences, Queen Mary, University of London...

308

E-Print Network 3.0 - acute phase gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

function and metabolism. Recent studies demonstrate that acute... proton nuclear magnetic resonance in mice subjected to acute CR. Liver and muscle showed increased gene... tissues...

309

Identification of cis-regulatory elements in mouse Mab21l2 gene by comparative genomics.  

E-Print Network [OSTI]

??The mab-21 gene was first identified in Caenorhabditis elegans as a critical component required for sensory organ identity determination. Mab21 homologs are highly conserved from (more)

Shek, Kim Fung

2010-01-01T23:59:59.000Z

310

E-Print Network 3.0 - acyl-coa dehydrogenase gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Is under the Dual Control... the original work is properly cited. PPAR and HNF4 are nuclear receptors that control gene ... Source: Ecole Polytechnique, Centre de...

311

Rodent phylogeny revised: analysis of six nuclear genes from all major rodent clades  

Science Journals Connector (OSTI)

We present here the largest protein-coding dataset used to study rodent relationships. It comprises six nuclear genes, 41 rodent species, and eight...

Shani Blanga-Kanfi; Hector Miranda; Osnat Penn; Tal Pupko

2009-04-01T23:59:59.000Z

312

E-Print Network 3.0 - alpha rara gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

found, some of the genes present... the classification, we excluded from Vijver's dataset all samples that presented mutations in the ... Source: Moscato, Pablo - Newcastle...

313

E-Print Network 3.0 - acid sphingomyelinase gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Microbial Pathogenesis () Summary: CAMP factor in GBS pathogenesis, the cfb gene encoding the pore-forming cytotoxin was deleted... by the combined action of...

314

E-Print Network 3.0 - abscisic-acid-inducible wrky gene Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in the transcriptional activation of the gene. In the meantime, ... Source: Alfan, James R. - Department of Plant Pathology, University of Nebraska-Lincoln Collection: Biology and...

315

E-Print Network 3.0 - acat1 gene expression Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 7 Copyright 2002 by the Genetics Society of America Mutations in the midway Gene Disrupt a Drosophila Acyl Coenzyme A Summary: with recombinant baculovirus...

316

Causal Gene Network Inference from Genetical Genomics Experiments via Structural Equation Modeling.  

E-Print Network [OSTI]

??The goal of this research is to construct causal gene networks for genetical genomics experiments using expression Quantitative Trait Loci (eQTL) mapping and Structural Equation (more)

Liu, Bing

2006-01-01T23:59:59.000Z

317

E-Print Network 3.0 - arthritis candidate genes Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

spondylitis; RA rheumatoid arthritis. Table 3. Allele... , Birlik, Onen, Bradman, Plaster. REFERENCES 1. French FMF Consortium. A candidate gene for familial... arthritis...

318

E-Print Network 3.0 - akirin gene family Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

two species, apparently due to frequent gene duplication... found to be a family of V1rs (Rodriguez et al., 2002). ... Source: Zhang, Jianzhi - Department of Ecology and...

319

E-Print Network 3.0 - adult gene therapy Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

potentiates a pound... -lasting tolerance to hFVIII and allows gene ... Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington...

320

E-Print Network 3.0 - assessing her2 gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

; Computer Technologies and Information Sciences 29 The life and death of gene families Jeffery P. Demuth,1 Summary: or for an increased arsenal of molecular weaponry. To assess...

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

E-Print Network 3.0 - avpr2 gene mutations Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

; Biology and Medicine 3 Current Pharmacogenomics, 2005, 3, 000-000 1 1570-160305 50.00+.00 2005 Bentham Science Publishers Ltd. Summary: vasopressin receptor gene...

322

E-Print Network 3.0 - analyzing time-series gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

series in terms of number... gene networks from time series include boolean network models, 5 Correlation Metric Construction, 6... - constructed time ... Source: D'haeseleer,...

323

E-Print Network 3.0 - alpha gene variants Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

KRT19 keratin... DKFZp564A072) GENE1188X AMACR ... Source: Leng, Chenlei - Department of Statistics and Applied Probability, National University of Singapore Collection:...

324

E-Print Network 3.0 - alpha subunit gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

KRT19 keratin... DKFZp564A072) GENE1188X AMACR ... Source: Leng, Chenlei - Department of Statistics and Applied Probability, National University of Singapore Collection:...

325

E-Print Network 3.0 - alpha gene expression Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

KRT19 keratin... DKFZp564A072) GENE1188X AMACR ... Source: Leng, Chenlei - Department of Statistics and Applied Probability, National University of Singapore Collection:...

326

E-Print Network 3.0 - acid-binding protein-7 gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

top 30 genes for the Brown Data set UID Name ... Source: Leng, Chenlei - Department of Statistics and Applied Probability, National University of Singapore Collection:...

327

A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes  

Science Journals Connector (OSTI)

A mouse embryonic stem cell bank of inducible human chromosome 21 gene expression is shown to be an important resource for investigating trisomy.

Rossella De Cegli; Antonio Romito; Simona Iacobacci; Lei Mao; Mario Lauria; Anthony O Fedele; Joachim Klose; Christelle Borel; Patrick Descombes; Stylianos E Antonarakis; Diego di Bernardo; Sandro Banfi; Andrea Ballabio; Gilda Cobellis

2010-06-22T23:59:59.000Z

328

Haploid genomes illustrate epigenetic constraints and gene dosage effects in mammals  

Science Journals Connector (OSTI)

As part of the Epigenetics Chromatin conference thematic series, Anton Wutz and Martin Leeb discuss how haploid genomes illustrate epigenetic constraints and gene dosage effects in mammals.

Martin Leeb; Anton Wutz

2013-12-05T23:59:59.000Z

329

E-Print Network 3.0 - algorithms gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

expression profiles has been developed, where various machine... , which adopts Kruskal-Wallis rank sum test to rank all genes and then apply an algorithm based......

330

E-Print Network 3.0 - alphaviruses gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1994. The alphaviruses: gene... of Marine Mammals: a New Alphavirus Isolated from the Elephant Seal Louse, Lepidophthirus macrorhini MAY LA... Accepted 29 January 2001 A novel...

331

E-Print Network 3.0 - assisted gene insertion Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and noncoding genes in the human genome Michele Clamp* , Ben Fry... ) Although the Human Genome Project was completed 4 years ago, the catalog of human protein-coding...

332

E-Print Network 3.0 - approaches gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

D: Knowledge Questions 1. You are investigating the changes in gene expression in cancer cells compared to normal cells Summary: Appendix D: Knowledge Questions 1. You are...

333

E-Print Network 3.0 - a-amylase inhibitor gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interaction of monoterpenes Summary: Molecular phylogenetic analysis of the potato a-amylase gene family reveals clustering into two distinct... - mediated tuber bud...

334

E-Print Network 3.0 - aphid resistance gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

gene confers resistance in tomato to certain clones of Macrosiphum euphorbiae (potato aphid), two... aphids progress through different feeding stages. Interestingly, the...

335

Accelerated Gene Evolution and Subfunctionalization in the Pseudotetraploid Frog Xenopus Laevis  

E-Print Network [OSTI]

Accelerated gene evolution and subfunctionalization in thethese triplets reveals accelerated evolution or relaxationbeen proposed to exhibit accelerated [31] or slowed [32

Hellsten, Uffe; Khokha, Mustafa K.; Grammar, Timothy C.; Harland, Richard M.; Richardson, Paul; Rokhsar, Daniel S.

2007-01-01T23:59:59.000Z

336

E-Print Network 3.0 - autophagy genes protect Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

that starvation induced the tran- scription of several autophagy genes... ). To test whether TFEB regulated the expres- sion of autophagy ... Source: Gleeson, Joseph G. -...

337

Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto  

DOE Patents [OSTI]

A novel gene has been isolated which encodes cytochrome b5 (CYTb5) protein of the .omega.-hydroxylase complex of C. tropicalis 20336. Vectors including this gene, and transformed host cells are provided. Methods of increasing the production of a CYTb5 protein are also provided which involve transforming a host cell with a gene encoding this protein and culturing the cells. Methods of increasing the production of a dicarboxylic acid are also provided which involve increasing in the host cell the number of genes encoding this protein.

Craft, David L. (Fort Thomas, KY); Madduri, Krishna M. (Westfield, IN); Loper, John C. (Cincinnati, OH)

2003-01-01T23:59:59.000Z

338

The nuclear OXPHOS genes in insecta: a common evolutionary origin, a common cis-regulatory motif, a common destiny for gene duplicates  

Science Journals Connector (OSTI)

We identified and annotated in the MitoComp2 dataset the orthologs of 68 nuclear genes controlling oxidative phosphorylation in 11 Drosophilidae...Fugu rubripes, Danio rerio and Homo sapiens) and in the cnidarian...

Damiano Porcelli; Paolo Barsanti; Graziano Pesole

2007-11-01T23:59:59.000Z

339

(E)-β-Ocimene and Myrcene Synthase Genes of Floral Scent Biosynthesis in Snapdragon: Function and Expression of Three Terpene Synthase Genes of a New Terpene Synthase Subfamily  

Science Journals Connector (OSTI)

...Methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase. Plant Mol. Biol. 51, 119-133. Gang, D.R., Lavid, N., Zubieta, C., Chen, F., Beuerle, T., Lewinsohn...

Natalia Dudareva; Diane Martin; Christine M. Kish; Natalia Kolosova; Nina Gorenstein; Jenny Fäldt; Barbara Miller; Jörg Bohlmann

2003-04-11T23:59:59.000Z

340

Human KZNF Gene Catalog - A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

Kruppel-type zinc finger (ZNF) motifs are prevalent components of transcription factor proteins in all eukaryotes. KRAB-ZNF proteins, in which a potent repressor domain is attached to a tandem array of DNA-binding zinc-finger motifs, are specific to tetrapod vertebrates and represent the largest class of ZNF proteins in mammals. To define the full repertoire of human KRAB-ZNF proteins, we searched the genome sequence for key motifs and then constructed and manually curated gene models incorporating those sequences. The resulting gene catalog contains 423 KRAB-ZNF protein-coding loci, yielding alternative transcripts that altogether predict at least 742 structurally distinct proteins. Active rounds of segmental duplication, involving single genes or larger regions and including both tandem and distributed duplication events, have driven the expansion of this mammalian gene family. Comparisons between the human genes and ZNF loci mined from the draft mouse, dog, and chimpanzee genomes not only identified 103 KRAB-ZNF genes that are conserved in mammals but also highlighted a substantial level of lineage-specific change; at least 136 KRAB-ZNF coding genes are primate specific, including many recent duplicates. KRAB-ZNF genes are widely expressed and clustered genes are typically not coregulated, indicating that paralogs have evolved to fill roles in many different biological processes. To facilitate further study, we have developed a Web-based public resource with access to gene models, sequences, and other data, including visualization tools to provide genomic context and interaction with other public data sets. [This abstract was copied from: S Huntley, DM Baggott, AT Hamilton, M Tran-Gyamfi, S Yang, J Kim, L Gordon, E Branscomb, and L Stubbs. 2006. A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors, Genome Research 16(5):669 - 677] The website provides the ability to search the online catalog by genomic coordinates, name, locus type, and motifs, to utilize a graphical browser and to download data files.

Huntley, S; Baggott, D.M.; Hamilton, A.T.; Tran-Gyamfi, M.; Yang, S.; Kim, J.; Gordon, L.; Branscomb, E.; Stubbs, L.

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus  

DOE Patents [OSTI]

The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.

Dai, Ziyu (Richland, WA); Lasure, Linda L. (Fall City, WA); Magnuson, Jon K. (Pasco, WA)

2008-11-11T23:59:59.000Z

342

Isolated Fungal Promoters and Gene Transcription Terminators and Methods of Protein and Chemical Production in a Fungus  

DOE Patents [OSTI]

The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.

Dai, Ziyu (Richland, WA); Lasure, Linda L. (Fall City, WA); Magnuson, Jon K. (Pasco, WA)

2008-11-11T23:59:59.000Z

343

A2 Processor User's Manual for Blue Gene/Q  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A2 Processor A2 Processor User's Manual for Blue Gene/Q Note: This document and the information it contains are provided on an as-is basis. There is no plan for providing for future updates and corrections to this document. October 23, 2012 Version 1.3 Title Page ® Copyright and Disclaimer © Copyright International Business Machines Corporation 2010, 2012 Printed in the United States of America October 2012 IBM, the IBM logo, and ibm.com are trademarks or registered trademarks of International Business Machines Corp., registered in many jurisdictions worldwide. Other product and service names might be trademarks of IBM or other compa- nies. A current list of IBM trademarks is available on the Web at "Copyright and trademark information" at www.ibm.com/legal/copytrade.shtml.

344

Cold, Salty and Promiscuous-Gene-shuffling Microbes Dominate  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

September 30, 2013 September 30, 2013 Cold, Salty and Promiscuous—Gene-shuffling Microbes Dominate Antarctica’s Deep Lake Sequestered in Antarctica's Vestfold Hills, Deep Lake became isolated from the ocean 3,500 years ago by the Antarctic continent rising, resulting in a saltwater ecosystem that remains liquid in extreme cold, and providing researchers a unique niche for studying the evolution of the microbes that now thrive under such conditions. Deep Lake's microscopic inhabitants are dominated by haloarchaea, microbes that require high salt concentrations to grow and are naturally adapted to conditions - at minus 20°C - that would prove lethally cold to other organisms. In a detailed analysis published online the week of September 30, 2013 in the journal Proceedings

345

Microsoft PowerPoint - gene_kight_panelist_presentation  

Broader source: Energy.gov (indexed) [DOE]

Fossil Energy R&D Fossil Energy R&D American Recovery & Reinvestment Act Projects 10 th Annual U.S. Department of Energy Small Business Conference Small Businesses Leading the Way to Recovery and Reinvestment Gene Kight Director, Finance and Procurement Office of Fossil Energy August 12, 2009 2 Small Businesses Leading the Way to Recovery and Reinvestment Expand and Extend Clean Coal Power Initiative (CCPI) Round 3 (Additional available CCPI funds total >$600 million) Industrial Carbon Capture and Storage Geologic Sequestration Site Characterization Geologic Sequestration Training & Research Carbon Capture and Storage (FutureGen Re-start) FE Program Direction $800 million $1.52 billion $50.0 million $20.0 million $1.0 billion

346

Microarray analysis of IFN-? response genes in astrocytes  

Science Journals Connector (OSTI)

IFN-gamma (IFN-?) has been shown to activate astrocytes to acquire immune functions. In this study the effect of IFN-? on murine astrocytes was investigated via microarray analysis. The activating effect of IFN-? on the astrocyte transcriptome showed predominance toward pathways involved in adaptive immunity, initiation of the immune response and innate immunity. Previously unknown astrocytic genes expressed included members of the p47 \\{GTPases\\} and guanine nucleotide binding protein (GBP) families. Down-regulatory effects of IFN-? stimulation were confined to pathways involved in growth regulation, cell differentiation and cell adhesion. This data supports the notion that astrocytes are an important immunocompetant cell in the brain and indicate that astrocytes may have a significant role in various infectious diseases such as Toxoplasmic Encephalitis and neurological diseases with an immunological component such as Alzheimer's and autoimmune disorders.

Sandra K. Halonen; Tyson Woods; Kate McInnerney; Louis M. Weiss

2006-01-01T23:59:59.000Z

347

Use of NAP gene to manipulate leaf senescence in plants  

DOE Patents [OSTI]

The present invention discloses transgenic plants having an altered level of NAP protein compared to that of a non-transgenic plant, where the transgenic plants display an altered leaf senescence phenotype relative to a non-transgenic plant, as well as mutant plants comprising an inactivated NAP gene, where mutant plants display a delayed leaf senescence phenotype compared to that of a non-mutant plant. The present invention also discloses methods for delaying leaf senescence in a plant, as well as methods of making a mutant plant having a decreased level of NAP protein compared to that of a non-mutant plant, where the mutant plant displays a delayed leaf senescence phenotype relative to a non-mutant plant. Methods for causing precocious leaf senescence or promoting leaf senescence in a plant are also disclosed. Also disclosed are methods of identifying a candidate plant suitable for breeding that displays a delayed leaf senescence and/or enhanced yield phenotype.

Gan, Susheng; Guo, Yongfeng

2013-04-16T23:59:59.000Z

348

LAMMPS strong scaling performance optimization on Blue Gene/Q  

SciTech Connect (OSTI)

LAMMPS "Large-scale Atomic/Molecular Massively Parallel Simulator" is an open-source molecular dynamics package from Sandia National Laboratories. Significant performance improvements in strong-scaling and time-to-solution for this application on IBM's Blue Gene/Q have been achieved through computational optimizations of the OpenMP versions of the short-range Lennard-Jones term of the CHARMM force field and the long-range Coulombic interaction implemented with the PPPM (particle-particle-particle mesh) algorithm, enhanced by runtime parameter settings controlling thread utilization. Additionally, MPI communication performance improvements were made to the PPPM calculation by re-engineering the parallel 3D FFT to use MPICH collectives instead of point-to-point. Performance testing was done using an 8.4-million atom simulation scaling up to 16 racks on the Mira system at Argonne Leadership Computing Facility (ALCF). Speedups resulting from this effort were in some cases over 2x.

Coffman, Paul; Jiang, Wei; Romero, Nichols A.

2014-11-12T23:59:59.000Z

349

Validation of a novel expressed sequence tag (EST) clustering method and development of a phylogenetic annotation pipeline for livestock gene families  

E-Print Network [OSTI]

Sequence EGAD Expressed Gene Anatomy Database BTGI Bos taurus Gene Indices GO Gene Ontology MAFFT Multiple Alignment Using Fast Fourier Transform viii TABLE OF CONTENTS Page ABSTRACT... Ontology Accession GO:0030295 from the Livestock EST Gene Family Database ........................................ 120 3.8 Search results for Bovine Oligo Microarray Consortium Locus 11695 from the Cattle EST Gene Family Database...

Venkatraman, Anand

2009-05-15T23:59:59.000Z

350

Technology development for gene discovery and full-length sequencing  

SciTech Connect (OSTI)

In previous years, with support from the U.S. Department of Energy, we developed methods for construction of normalized and subtracted cDNA libraries, and constructed hundreds of high-quality libraries for production of Expressed Sequence Tags (ESTs). Our clones were made widely available to the scientific community through the IMAGE Consortium, and millions of ESTs were produced from our libraries either by collaborators or by our own sequencing laboratory at the University of Iowa. During this grant period, we focused on (1) the development of a method for preferential cloning of tissue-specific and/or rare transcripts, (2) its utilization to expedite EST-based gene discovery for the NIH Mouse Brain Molecular Anatomy Project, (3) further development and optimization of a method for construction of full-length-enriched cDNA libraries, and (4) modification of a plasmid vector to maximize efficiency of full-length cDNA sequencing by the transposon-mediated approach. It is noteworthy that the technology developed for preferential cloning of rare mRNAs enabled identification of over 2,000 mouse transcripts differentially expressed in the hippocampus. In addition, the method that we optimized for construction of full-length-enriched cDNA libraries was successfully utilized for the production of approximately fifty libraries from the developing mouse nervous system, from which over 2,500 full-ORF-containing cDNAs have been identified and accurately sequenced in their entirety either by our group or by the NIH-Mammalian Gene Collection Program Sequencing Team.

Marcelo Bento Soares

2004-07-19T23:59:59.000Z

351

Gene galaxies in the maize genome Virginia Walbot* and Dmitri A. Petrov  

E-Print Network [OSTI]

Commentary Gene galaxies in the maize genome Virginia Walbot* and Dmitri A. Petrov Department of higher eukary- otic genomes yielded the surprise that despite hundreds of millions of years in gene number, eukaryotic genome size varies over 5 orders of magnitude (4), a paradoxical feature

Petrov, Dmitri

352

TECHNICAL ADVANCE The ethanol switch: a tool for tissue-specic gene induction  

E-Print Network [OSTI]

TECHNICAL ADVANCE The ethanol switch: a tool for tissue-speci®c gene induction during plant is a powerful tool for the analysis of gene function during plant development. Here, we report ethanol inducible of an ethanol-regulated transcription factor, ALCR, is restricted to precise domains using speci®c promoters

Murray, J.A.H.

353

Techniques for the removal of marker genes from transgenic plants Charles P. Scutt a,  

E-Print Network [OSTI]

reason to warrant their removal. In addition to environmental and health concerns, there are alsoReview Techniques for the removal of marker genes from transgenic plants Charles P. Scutt a of problems. Various techniques are under development for the removal of unwanted marker genes, while leaving

Meyer, Peter

354

Expression of an Arabidopsis vacuolar -pyrophosphatase gene (AVP1) in cotton improves  

E-Print Network [OSTI]

Expression of an Arabidopsis vacuolar H+ -pyrophosphatase gene (AVP1) in cotton improves drought, pro- ton pump, root development, salt stress, transgenic cotton. Summary The Arabidopsis gene AVP1 conditions. Using the same approach, AVP1-expressing cotton plants were created and tested

Blumwald, Eduardo

355

Expression of an Arabidopsis vacuolar -pyrophosphatase gene (AVP1) in cotton improves  

E-Print Network [OSTI]

Expression of an Arabidopsis vacuolar H+ -pyrophosphatase gene (AVP1) in cotton improves drought- ton pump, root development, salt stress, transgenic cotton. Summary The Arabidopsis gene AVP1 encodes-expressing cotton plants were created and tested for their performance under high-salt and reduced irrigation

Blumwald, Eduardo

356

Alternative splicing and genomic structure of the Wilms tumor gene WT1.  

Science Journals Connector (OSTI)

...chromosome 11p13 WiU tumor suscepti- bility gene WTI appears to play a cucial role in regulating...dfrnai of nephrobasts and god tis- sue. The WTI gene consistsof 1lexons, ig a pattern of...kidney and in various mouse tissues expeing WTI. The conservation in stuctre and relative...

D A Haber; R L Sohn; A J Buckler; J Pelletier; K M Call; D E Housman

1991-01-01T23:59:59.000Z

357

Nuclear gene phylogeography reveals the historical legacy of an ancient inland sea on lineages of the  

E-Print Network [OSTI]

a dataset comprised of one mitochondrial and five nuclear loci, we elucidate the major biogeographicNuclear gene phylogeography reveals the historical legacy of an ancient inland sea on lineages of California. In addition, discordant mitochondrial/ nuclear genetic patterns suggest subsequent gene flow from

Grether, Gregory

358

Single-Copy Nuclear Genes Place Haustorial Hydnoraceae within Piperales and Reveal a Cretaceous  

E-Print Network [OSTI]

Single-Copy Nuclear Genes Place Haustorial Hydnoraceae within Piperales and Reveal a Cretaceous, we extracted 14 nuclear single copy genes (nSCG) from Illumina transcriptome data from one of the ``strangest plants in the world'', Hydnora visseri (Hydnoraceae). A ,15,000 character molecular dataset, based

dePamphilis, Claude

359

Origins of anteroposterior patterning and Hox gene regulation during chordate evolution  

Science Journals Connector (OSTI)

...have a similar basic plan, with an anterior end...many early developmental regulatory genes in protochordates...of the vertebrate body plan it is important to determine...reveal how developmental regulatory genes control AP patterning in vertebrates (for reviews, see Cappechi 1997...

2001-01-01T23:59:59.000Z

360

Evolution of Red Algal Plastid Genomes: Ancient Architectures, Introns, Horizontal Gene Transfer, and  

E-Print Network [OSTI]

Evolution of Red Algal Plastid Genomes: Ancient Architectures, Introns, Horizontal Gene Transfer, Station Biologique, Roscoff, France Abstract Red algae have the most gene-rich plastid genomes known across all available red algal plastid genomes we show they all share a highly compact and slowly

Martone, Patrick T.

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Association of isozyme marker-genes on chromosome 6 with resistance to MDMV in maize  

E-Print Network [OSTI]

in the estimated number of resistance genes, even for the same genotype. MATERIALS AND METHODS The choiceAssociation of isozyme marker-genes on chromosome 6 with resistance to MDMV in maize D Ignjatovi homozygous lines were chosen by both divergence in MDMV resistance and presence of segregating isozyme

Boyer, Edmond

362

BioThesaurus: a web-based thesaurus of protein and gene names  

Science Journals Connector (OSTI)

......text mining BioThesaurus: a web-based thesaurus of protein and gene names Hongfang Liu...web-based system BioThesaurus that maps a thesaurus of protein and gene names extracted from...construction is shown in Figure 1. The thesaurus was designed to provide comprehensive......

Hongfang Liu; Zhang-Zhi Hu; Jian Zhang; Cathy Wu

2006-01-01T23:59:59.000Z

363

Genetic analyses of bovine CARD15, a putative disease resistance gene  

E-Print Network [OSTI]

Through a binding partner the CARD15 gene activates NF-kB, a molecule with a role in the initiation of the inflammatory immune response. The gene is highly conserved in both structure and function in human and mouse and has recently been implicated...

Taylor, Kristen Hawkins

2004-09-30T23:59:59.000Z

364

Genetic analysis of a locus on the Bacteroides ovatus chromosome which contains xylan utilization genes.  

Science Journals Connector (OSTI)

...ovatus chromosome which contains xylan utilization genes. J Weaver...O'Brien. 1981. Utilization of xylan by two species of human colonic...in binding of starch to the surface of Bacteroides thetaiotaomicron...1990. The genes for three xylan-degrading activities from...

J Weaver; T R Whitehead; M A Cotta; P C Valentine; A A Salyers

1992-09-01T23:59:59.000Z

365

Gene expression of beta-defensins in chicken white blood cells  

E-Print Network [OSTI]

beta-defensins have been identified; however, the regulation of these genes has not been well-investigated in the chicken. The objective of this research was to understand constitutive and inducible gene expression of beta-defensins in chicken white...

Supak, Tiffany Marie

2009-06-02T23:59:59.000Z

366

Beyond Synexpression Relationships: Local Clustering of Time-shifted and Inverted Gene  

E-Print Network [OSTI]

Beyond Synexpression Relationships: Local Clustering of Time-shifted and Inverted Gene Expression an inverted relationship. Here, we propose a new method, which we call local clus- tering, for identifying these time-delayed and inverted relationships. It is related to conventional gene-expression clustering

Yu, Haiyuan

367

PDGF-Receptor ?-Targeted Adenovirus Redirects Gene Transfer from Hepatocytes to Activated Stellate Cells  

Science Journals Connector (OSTI)

Department of Gastroenterology and Hepatology, Department of Therapeutic Gene Modulation, and Department of Pharmacokinetics and Drug Delivery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands ... Mailing address: Department of Therapeutic Gene Modulation, University of Groningen, Ant. ... Deusinglaan 1, 9713 AV Groningen, The Netherlands. ...

Marieke H. Schoemaker; Marianne G. Rots; Leonie Beljaars; Arjen Y. Ypma; Peter L. M. Jansen; Klaas Poelstra; Han Moshage; Hidde J. Haisma

2008-01-25T23:59:59.000Z

368

The investigation of controlled release microchips, nanoparticles, and sirna for gene therapy in tissue engineering applications  

E-Print Network [OSTI]

to a decrease in viability of the cells. It was also noted that the method of cell death is likely to be apoptosis. To confirm the efficacy of gene therapy through transfection, the transfection of the serum response factor (SRF) gene plasmid DNA...

Chern, Christina

2009-05-15T23:59:59.000Z

369

The probability distribution of ranked gene trees on a species tree James H. Degnan a,  

E-Print Network [OSTI]

The probability distribution of ranked gene trees on a species tree James H. Degnan a, , Noah A. Rosenberg b , Tanja Stadler c a Department of Mathematics and Statistics, Private Bag 4800, University and the sequence of coalescences for a random gene tree are considered. We derive the probability distribution

Rosenberg, Noah

370

An algorithm for identifying clusters of functionally related genes in genomes  

E-Print Network [OSTI]

rise to them. I present a basis of algorithm to identify gene clusters in eukaryotic genomes that utilizes functional categories defined in graph-based vocabularies such as the Gene Ontology (GO). Clusters identified in this manner need only have a...

Yi, Gang Man

2009-05-15T23:59:59.000Z

371

Inferring the Evolutionary History of IncP-1 Plasmids Despite Incongruence among Backbone Gene Trees  

E-Print Network [OSTI]

for human health and environmental remediation. Although it is well understood that the accessory genes is expected to produce conflicting gene tree topologies. The main goal of this study was therefore to infer; Sen et al. 2011), streams (Smalla et al. 2006; Akiyama et al. 2010), and waste- water treatment plants

Sullivan, Jack

372

Plasmids containing the gene for DNA polymerase I from Streptococcus pneumoniae  

DOE Patents [OSTI]

A method is disclosed for cloning the gene which encodes a DNA polymerase-exonuclease of /und Streptococcus/ /und pneumoniae/. Plasmid pSM22, the vector containing the pneumococcal polA gene, facilitates the expression of 50-fold greater amounts of the PolI enzyme. 1 fig., 1 tab.

Lacks, S.A.; Martinez, S.; Lopez, P.; Espinosa, M.

1987-08-28T23:59:59.000Z

373

Structure and transforming function of transduced mutant alleles of the chicken c-myc gene.  

Science Journals Connector (OSTI)

...chicken c-myc gene. T Patschinsky H W Jansen H Blocker R Frank K Bister A small retroviral...c-myc Gene TILO PATSCHINSKY,' HANS W. JANSEN,1t HELMUT BLOCKER,2 RONALD FRANK...5, 7, 59; K. Bister and H. W. Jansen, Adv. Cancer Res., in press). The...

T Patschinsky; H W Jansen; H Blcker; R Frank; K Bister

1986-08-01T23:59:59.000Z

374

VALIDATION OF IMPRINTED GENES ON HUMAN CHROMOSOME 6 EXPRESSED IN THE PLACENTA  

E-Print Network [OSTI]

VALIDATION OF IMPRINTED GENES ON HUMAN CHROMOSOME 6 EXPRESSED IN THE PLACENTA Anna Brenneman (Jill, which results in inadequate blood flow and nutrient transfer to the developing fetus. Genomic imprinting in a developmental stage-specific manner in human placenta. Our goal is to better define the set of imprinted genes

Zhou, Yaoqi

375

What is genetic research? Genes are part of every cell in every  

E-Print Network [OSTI]

Genetic Research What is genetic research? Genes are part of every cell in every person. Genes come volunteers More questions? Call: Questions to ask 1. What is the purpose of the study? 2. How will you collect my genetic sample? 3. Will I, or anyone else, receive results from this study? 4. What happens

Church, George M.

376

Gene Expression Profiles during the Initial Phase of Salt Stress in Rice  

Science Journals Connector (OSTI)

...and photoperiodic flowering by the Arabidopsis GIGANTEA gene Price A.H. Young E.M. Tomos A.D. Quantitative trait loci...three rice sucrose synthase genes Yang S.F. Hoffman N.E. Ethylene biosynthesis and its regulation in higher plants Yeo A.R...

Shinji Kawasaki; Chris Borchert; Michael Deyholos; Hong Wang; Susan Brazille; Kiyoshi Kawai; David Galbraith; Hans J. Bohnert

377

Seamless Correction of the Sickle Cell Disease Mutation of the HBB Gene in Human Induced  

E-Print Network [OSTI]

Seamless Correction of the Sickle Cell Disease Mutation of the HBB Gene in Human Induced ABSTRACT: Sickle cell disease (SCD) is the most common human genetic disease which is caused by a single effector nucleases; induced pluripotent stem cells; piggyBac transposon; sickle cell disease; gene therapy

Zhao, Huimin

378

NHR-23 dependent collagen and hedgehog-related genes required for molting  

SciTech Connect (OSTI)

Highlights: {yields} NHR-23 is a critical regulator of nematode development and molting. {yields} The manuscript characterizes the loss-of-function phenotype of an nhr-23 mutant. {yields} Whole genome expression analysis identifies new potential targets of NHR-23. {yields} Hedgehog-related genes are identified as NHR-23 dependent genes. {yields} New link between sterol mediated signaling and regulation by NHR-23 is found. -- Abstract: NHR-23, a conserved member of the nuclear receptor family of transcription factors, is required for normal development in Caenorhabditis elegans where it plays a critical role in growth and molting. In a search for NHR-23 dependent genes, we performed whole genome comparative expression microarrays on both control and nhr-23 inhibited synchronized larvae. Genes that decreased in response to nhr-23 RNAi included several collagen genes. Unexpectedly, several hedgehog-related genes were also down-regulated after nhr-23 RNAi. A homozygous nhr-23 deletion allele was used to confirm the RNAi knockdown phenotypes and the changes in gene expression. Our results indicate that NHR-23 is a critical co-regulator of functionally linked genes involved in growth and molting and reveal evolutionary parallels among the ecdysozoa.

Kouns, Nathaniel A.; Nakielna, Johana; Behensky, Frantisek [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic)] [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic); Krause, Michael W. [Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (United States)] [Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (United States); Kostrouch, Zdenek [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic)] [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic); Kostrouchova, Marta, E-mail: marta.kostrouchova@lf1.cuni.cz [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic)] [Laboratory of Model Systems, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague (Czech Republic)

2011-10-07T23:59:59.000Z

379

Cell Cycle-regulated Gene Expression in Arabidopsis* Received for publication, July 26, 2002  

E-Print Network [OSTI]

Cell Cycle-regulated Gene Expression in Arabidopsis* Received for publication, July 26, 2002¨rich, Switzerland Regulated gene expression is an important mecha- nism for controlling cell cycle progression regulation de- pendent on cell cycle position. Analysis of cell cycle processes in plants has been hampered

Murray, J.A.H.

380

ATLAS on the BlueGene/L Preliminary Results Keith Seymour Haihang You Jack Dongarra  

E-Print Network [OSTI]

ATLAS on the BlueGene/L ­ Preliminary Results Keith Seymour Haihang You Jack Dongarra Department The goal of this work is to use ATLAS to produce a tuned linear algebra library for the BlueGene/L, while of the machine present a few difficulties for a straightforward port of ATLAS. The compute nodes themselves

Dongarra, Jack

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

GeneEnvironment Interaction Involving Recently Identified Colorectal Cancer Susceptibility Loci  

Science Journals Connector (OSTI)

...NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and WY. PLCO: The...lung datasets were accessed from the dbGaP website ( http://www.ncbi.nlm.nih.gov...Brenner H, Buchanan D, et alGenome-wide search for gene-gene interactions in colorectal...

Elizabeth D. Kantor; Carolyn M. Hutter; Jessica Minnier; Sonja I. Berndt; Hermann Brenner; Bette J. Caan; Peter T. Campbell; Christopher S. Carlson; Graham Casey; Andrew T. Chan; Jenny Chang-Claude; Stephen J. Chanock; Michelle Cotterchio; Mengmeng Du; David Duggan; Charles S. Fuchs; Edward L. Giovannucci; Jian Gong; Tabitha A. Harrison; Richard B. Hayes; Brian E. Henderson; Michael Hoffmeister; John L. Hopper; Mark A. Jenkins; Shuo Jiao; Laurence N. Kolonel; Loic Le Marchand; Mathieu Lemire; Jing Ma; Polly A. Newcomb; Heather M. Ochs-Balcom; Bethann M. Pflugeisen; John D. Potter; Anja Rudolph; Robert E. Schoen; Daniela Seminara; Martha L. Slattery; Deanna L. Stelling; Fridtjof Thomas; Mark Thornquist; Cornelia M. Ulrich; Greg S. Warnick; Brent W. Zanke; Ulrike Peters; Li Hsu; and Emily White

2014-09-01T23:59:59.000Z

382

Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species  

Science Journals Connector (OSTI)

An RFX-binding site is shown to be conserved in the promoters of a subset of ciliary genes and a subsequent screen for this site in two Drosophila species identified novel RFX target genes that are involved in sensory ciliogenesis.

Anne Laurenon; Raphalle Dubruille; Evgeni Efimenko; Guillaume Grenier; Ryan Bissett; Elisabeth Cortier; Vivien Rolland; Peter Swoboda; Bndicte Durand

2007-09-17T23:59:59.000Z

383

Positive selection at the ASPM gene coincides with brain size enlargements in cetaceans  

Science Journals Connector (OSTI)

...selection at the ASPM gene coincides with brain size enlargements in cetaceans Shixia Xu...Republic of China The enlargement of cetacean brain size represents an enigmatic event in mammalian...explored. One candidate gene associated with brain size evolution is the abnormal spindle-like...

2012-01-01T23:59:59.000Z

384

The NGATHA Distal Organ Development Genes Are Essential for Style Specification in Arabidopsis  

Science Journals Connector (OSTI)

...development. Another general process having a patterning role in...additonal understanding as to the processes regulated by NGA gene activity...limits our understanding of the processes of morphogenesis in plants...transport, and these could be interrelated. The NGA Genes Are Essential...

John Paul Alvarez; Alexander Goldshmidt; Idan Efroni; John L. Bowman; Yuval Eshed

2009-05-12T23:59:59.000Z

385

Nuclear and Mitochondrial Genes Contain Similar Phylogenetic Signal for Pigeons and Doves (Aves: Columbiformes)  

E-Print Network [OSTI]

Nuclear and Mitochondrial Genes Contain Similar Phylogenetic Signal for Pigeons and Doves (Aves of this assumption in the pigeons and doves (Aves: Columbiformes) by comparing phylog- enies derived from nuclear incongruence between trees derived from the two genes; so, we combined nuclear and mitochondrial data

Clayton, Dale H.

386

Hierarchical Analysis of Population Genetic Variation in Mitochondrial and Nuclear Genes of Daphnia pulex'  

E-Print Network [OSTI]

Hierarchical Analysis of Population Genetic Variation in Mitochondrial and Nuclear Genes of Daphnia in part to the limited dispersal ability of Daphnia. However, previous work has shown that fluctuating as rapidly with distance as does that for nuclear genes, which is slower than the neutral expectation

Lynch, Michael

387

Functional gene groups are concentrated within chromosomes, among chromosomes and in the nuclear space  

E-Print Network [OSTI]

1 Functional gene groups are concentrated within chromosomes, among chromosomes and in the nuclear;2 Functional gene groups are concentrated within chromosomes, among chromosomes and in the nuclear space of their dispersal over several chromosomes. Moreover, using Hi-C contact map of the tendency of chromosomal segments

Shamir, Ron

388

Compensatory cis-trans Evolution and the Dysregulation of Gene Expression in Interspecific Hybrids of Drosophila  

E-Print Network [OSTI]

Hybrids of Drosophila Christian R. Landry* , Patricia J. Wittkopp , Clifford H. Taubes , Jose M. Ranz.047449 #12;2 Running head: Gene and expression in interspecific hybrids Key words: Gene regulation, Drosophila, hybrid, dysregulation, allele-specific expression Corresponding author: Daniel L. Hartl

Gruber, Jonathan

389

FUNCTIONAL ANNOTATION OF OIL PALM GENES USING AN AUTOMATED BIOINFORMATICS APPROACH FUNCTIONAL ANNOTATION OF OIL PALM  

E-Print Network [OSTI]

FUNCTIONAL ANNOTATION OF OIL PALM GENES USING AN AUTOMATED BIOINFORMATICS APPROACH 35 FUNCTIONAL ANNOTATION OF OIL PALM GENES USING AN AUTOMATED BIOINFORMATICS APPROACH LAURA B WILLIS*; PHILIP A LESSARDBank, and duplicate entries were eliminated by pairwise BLAST searches, resulting in a collection of unique oil palm

Sinskey, Anthony J.

390

Use of the Transposon Ac as a Gene-Searching Engine in the Maize Genome  

Science Journals Connector (OSTI)

...an excellent gene-searching engine in the highly repetitive maize...The Mutants of Maize. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press). Parinov...transposon Ac as a gene-searching engine in the maize genome. | We show...

Matthew Cowperthwaite; Wonkeun Park; Zhennan Xu; Xianghe Yan; Steven C. Maurais; Hugo K. Dooner

2002-03-08T23:59:59.000Z

391

Horizontal gene transfer and the evolution of transcriptionalregulation in Escherichia coli  

SciTech Connect (OSTI)

Background: Most bacterial genes were acquired by horizontalgene transfer from other bacteria instead of being inherited bycontinuous vertical descent from an ancient ancestor}. To understand howthe regulation of these {acquired} genes evolved, we examined theevolutionary histories of transcription factors and of regulatoryinteractions from the model bacterium Escherichia coli K12. Results:Although most transcription factors have paralogs, these usually arose byhorizontal gene transfer rather than by duplication within the E. colilineage, as previously believed. In general, most neighbor regulators --regulators that are adjacent to genes that they regulate -- were acquiredby horizontal gene transfer, while most global regulators evolvedvertically within the gamma-Proteobacteria. Neighbor regulators wereoften acquired together with the adjacent operon that they regulate, sothe proximity might be maintained by repeated transfers (like "selfishoperons"). Many of the as-yet-uncharacterized (putative) regulators havealso been acquired together with adjacent genes, so we predict that theseare neighbor regulators as well. When we analyzed the histories ofregulatory interactions, we found that the evolution of regulation byduplication was rare, and surprisingly, many of the regulatoryinteractions that are shared between paralogs result from convergentevolution. Another surprise was that horizontally transferred genes aremore likely than other genes to be regulated by multiple regulators, andmost of this complex regulation probably evolved after the transfer.Conclusions: Our results highlight the rapid evolution of niche-specificgene regulation in bacteria.

Price, Morgan N.; Dehal, Paramvir S.; Arkin, Adam P.

2007-12-20T23:59:59.000Z

392

A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair  

Science Journals Connector (OSTI)

Current strategies for gene therapy of inherited diseases consist in adding functional copies of the gene that is defective. An attractive alternative to these approaches would be to correct the endogenous mutate...

Xavier Leclerc; Olivier Danos; Daniel Scherman; Antoine Kichler

2009-04-01T23:59:59.000Z

393

Mechanisms of hormonal regulation of CAD gene expression and inhibition by Aryl hydrocarbon receptor agonist in human breast cancer cells  

E-Print Network [OSTI]

The CAD gene is trifunctional and expresses carbamoylphosphate synthetase/aspartate carbamyltransferase/dihydroorotase, which are required for pyrimidine biosynthesis. CAD gene activities are induced in MCF-7 human breast cancer cells, and treatment...

Khan, Shaheen Munawar Ali

2007-04-25T23:59:59.000Z

394

Cascade: a R package to study, predict and simulate the diffusion of a signal through a temporal gene network  

Science Journals Connector (OSTI)

......their underlying gene regulatory network (GRN) (Bar-Joseph...Systems Biology, plan cancer 2009-2013...Hecker M , et al. Gene regulatory network inference...in dynamic models-a review. Biosystems (2009...Genomic analysis of regulatory network dynamics reveals......

Nicolas Jung; Frdric Bertrand; Seiamak Bahram; Laurent Vallat; Myriam Maumy-Bertrand

2014-02-15T23:59:59.000Z

395

Down-Regulation of Homeobox Gene GBX2 Expression Inhibits Human Prostate Cancer Clonogenic Ability and Tumorigenicity  

Science Journals Connector (OSTI)

...283-302. 1992. 3. Shashikant, C. S.. and Violette. S. M. Homeobox genes in mouse development...945-952, 1995. 10. Friedmann, Y.. Daniel. C. A.. Strickland, P., and Daniel, C. W. Hox genes in normal and neoplastic...

Allen C. Gao; Wei Lou; and John T. Isaacs

1998-04-01T23:59:59.000Z

396

Isolation and molecular genetic characterization of the Bacillus subtilis gene (infB) encoding protein synthesis initiation factor 2.  

Science Journals Connector (OSTI)

...genetic characterization of the Bacillus subtilis gene (infB) encoding protein...blot (immunoblot) analysis of Bacillus subtilis cell extracts detected two proteins...genetic characterization of the Bacillus subtilis gene (infB) encoding protein...

K Shazand; J Tucker; R Chiang; K Stansmore; H U Sperling-Petersen; M Grunberg-Manago; J C Rabinowitz; T Leighton

1990-05-01T23:59:59.000Z

397

Inhibition of Repair of Radiation-Induced DNA Damage Enhances Gene Expression from Replication-Defective Adenoviral Vectors  

Science Journals Connector (OSTI)

...those related to increased expression of CAR and integrin are responsible for the enhanced...of gene expression from replication-defective adenoviral vectors: implications for...enhances gene expression from replication-defective adenoviral vectors. | Radiation has been...

Mohan Hingorani; Christine L. White; Andrew Merron; Inge Peerlinck; Martin E. Gore; Andrew Slade; Simon D. Scott; Christopher M. Nutting; Hardev S. Pandha; Alan A. Melcher; Richard G. Vile; Georges Vassaux; and Kevin J. Harrington

2008-12-01T23:59:59.000Z

398

A MACHINE LEARNING APPROACH TO QUERY TIME-SERIES MICROARRAY DATA SETS FOR FUNCTIONALLY RELATED GENES USING HIDDEN MARKOV MODELS  

E-Print Network [OSTI]

Microarray technology captures the rate of expression of genes under varying experimental conditions. Genes encode the information necessary to build proteins; proteins used by cellular functions exhibit higher rates of ...

Senf, Alexander J.

2011-02-04T23:59:59.000Z

399

Automation of Drosophila gene expression pattern image annotation : development of web-based image annotation tool and application of machine learning methods  

E-Print Network [OSTI]

Large-scale in situ hybridization screens are providing an abundance of spatio-temporal patterns of gene expression data that is valuable for understanding the mechanisms of gene regulation. Drosophila gene expression ...

Ayuso, Anna Maria E

2011-01-01T23:59:59.000Z

400

Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: A case control study  

E-Print Network [OSTI]

and mitochondrial enzymes and risk for progressiveand mitochondrial enzymes and risk for progressivein genes encoding enzymes of xenobiotic detoxification,

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Uncovering the Molecular Secrets of Inflammatory Breast Cancer Biology: An Integrated Analysis of Three Distinct Affymetrix Gene Expression Datasets  

Science Journals Connector (OSTI)

...differentially expressed genes in the datasets generated from the different...multiple gene expression profiling datasets, the common gene signatures...10606 PCNA Proliferating cell nuclear antigen 20pter-p12 5111 PMAIP1...value of proliferating cell nuclear antigen (PCNA) and p53 protein...

Steven J. Van Laere; Naoto T. Ueno; Pascal Finetti; Peter Vermeulen; Anthony Lucci; Fredika M. Robertson; Melike Marsan; Takayuki Iwamoto; Savitri Krishnamurthy; Hiroko Masuda; Peter van Dam; Wendy A. Woodward; Patrice Viens; Massimo Cristofanilli; Daniel Birnbaum; Luc Dirix; James M. Reuben; and Franois Bertucci

2013-09-01T23:59:59.000Z

402

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima  

E-Print Network [OSTI]

insect chemosensory genes, included in six gene families; three ligand binding protein families: Odorant Binding Proteins (OBP; [56,57]), Chemosensory Proteins (CSP; [58,59]) and Che... proteins, we found only two genes belonging to the CSP family, but no representatives of the OBP or CheA/B families. Among the membrane receptor families, we identified a...

Chipman, Ariel D.; Ferrier, David E. K.; Brena, Carlo; Qu, Jiaxin; Hughes, Daniel S. T.; Schrder, Reinhard; Torres-Oliva, Montserrat; Znassi, Nadia; Jiang, Huaiyang; Almeida, Francisca C.; Alonso, Claudio R.; Apostolou, Zivkos; Aqrawi, Peshtewani; Arthur, Wallace; Barna, Jennifer C. J.; Blankenburg, Kerstin P.; Brites, Daniela; Capella-Gutirrez, Salvador; Coyle, Marcus; Dearden, Peter K.; Du Pasquier, Louis; Duncan, Elizabeth J.; Ebert, Dieter; Eibner, Cornelius; Erikson, Galina; Evans, Peter D.; Extavour, Cassandra G.; Francisco, Liezl; Gabaldn, Toni; Gillis, William J.; Goodwin-Horn, Elizabeth A.; Green, Jack E.; Griffiths-Jones, Sam; Grimmelikhuijzen, Cornelis J. P.; Gubbala, Sai; Guig, Roderic; Han, Yi; Hauser, Frank; Havlak, Paul; Hayden, Luke; Helbing, Sophie; Holder, Michael; Hui, Jerome H. L.; Hunn, Julia P.; Hunnekuhl, Vera S.; Jackson, LaRonda; Javaid, Mehwish; Jhangiani, Shalini N.; Jiggins, Francis M.; Jones, Tamsin E.; Kaiser, Tobias S.; Kalra, Divya; Kenny, Nathan J.; Korchina, Viktoriya; Kovar, Christie L.; Kraus, F. Bernhard; Lapraz, Franois; Lee, Sandra L.; Lv, Jie; Mandapat, Christigale; Manning, Gerard; Mariotti, Marco; Mata, Sandra; Mathew, Tittu; Neumann, Tobias; Newsham, Irene; Ngo, Dinh N.; Ninova, Maria; Okwuonu, Geoffrey; Ongeri, Fiona; Palmer, William J.; Patil, Shobha; Patraquim, Pedro; Pham, Christopher; Pu, Ling?Ling; Putman, Nicholas H.; Rabouille, Catherine; Ramos, Olivia Mendivil; Rhodes, Adelaide C.; Robertson, Helen E.; Robertson, Hugh M.; Ronshaugen, Matthew; Rozas, Julio; Saada, Nehad; Snchez-Gracia, Alejandro; Scherer, Steven E.; Schurko, Andrew M.; Siggens, Kenneth W.; Simmons, DeNard; Stief, Anna; Stolle, Eckart; Telford, Maximilian J.; Tessmar- Raible, Kristin; Thornton, Rebecca; van der Zee, Maurijn; von Haeseler, Arndt; Williams, James M.; Willis, Judith H.; Wu, Yuanqing; Zou, Xiaoyan; Lawson, Daniel; Muzny, Donna M.; Worley, Kim C.; Gibbs, Richard A.; Akam, Michael; Richards, Stephen

2014-01-01T23:59:59.000Z

403

Diversification of the monoterpene synthase gene family (TPSb) in Protium, a highly diverse genus of tropical trees  

E-Print Network [OSTI]

such as the exposure to high temperatures or the oxidative damage due to the accumulation of reactive oxygen (Vickers. These genes are part of the highly diverse TPS gene family (Bohlmann et al., 1998; Chen et al., 2011) and playDiversification of the monoterpene synthase gene family (TPSb) in Protium, a highly diverse genus

Fine, Paul V.A.

404

Systemic Expression of HIV-1 tat Gene in Transgenic Mice Induces Endothelial Proliferation and Tumors of Different Histotypes  

Science Journals Connector (OSTI)

...Articles Virology Systemic Expression of HIV-1 tat Gene in Transgenic Mice Induces Endothelial...progression to a malignant phenotype. The HIV tat gene, introduced into the germ line...containing BKV early region and the HIV tat gene, directed by its own promoter...

Alfredo Corallini; Giuseppe Altavilla; Laura Pozzi; Francesca Bignozzi; Massimo Negrini; Paola Rimessi; Francesca Gualandi; and Giuseppe Barbanti-Brodano

1993-11-15T23:59:59.000Z

405

Multiple nuclear genes and retroposons support vicariance and dispersal of the palaeognaths, and an Early Cretaceous origin of modern birds  

Science Journals Connector (OSTI)

...research-article Research articles 1001 70 Multiple nuclear genes and retroposons support vicariance...the major palaeognath lineages using 27 nuclear genes and 27 archaic retroposon insertions...5]. Recent analyses using multiple nuclear gene sequences of major clades of birds...

2012-01-01T23:59:59.000Z

406

THE ROLE OF SYNTHETIC DNA IN THE PREPARATION OF STRUCTURAL GENES CODING FOR PROTEINS  

Science Journals Connector (OSTI)

Publisher Summary This chapter discusses the role of synthetic DNA in the preparation of structural genes coding for proteins. One of the key steps in the production of proteins by recombinant DNA technology is the preparation of structural genes coding for the desired proteins. There may be two approaches to this goal: (1) artificial gene synthesis and (2) a combination of cloned cDNA sequences and synthetic DNAs. The method of artificial gene synthesis for the preparation of artificial genes was developed for the synthesis of genes for tRNAs in the late 1960s. The approach of combination of cloned cDNA sequences and synthetic DNA has been developed for the preparation of a gene coding for the human growth hormone. The chapter describes an alternative approach for the synthesis of polydeoxyribonucleotides with defined sequences longer than those accessible by conventional chemical methods. Recent advances in the chemical synthesis of oligonucleotides help to synthesize single-stranded oligonucleotides of up to 40 bases in length, rapidly. It is now possible to synthesize double-stranded DNA fragments using DNA polymerase I in the presence of four deoxynucleoside triphosphosphates.

John J. Rossi; Ryszard Kierzek; Ting Huang; Peter Walker; Keiichi Itakura

1982-01-01T23:59:59.000Z

407

Self-assembled pentablock copolymers for selective and sustained gene delivery  

SciTech Connect (OSTI)

The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

Zhang, Bingqi

2011-05-15T23:59:59.000Z

408

Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate  

SciTech Connect (OSTI)

Pretreatment of mice with the peroxisome proliferator clofibrate (CFB) protects against acetaminophen (APAP)-induced hepatotoxicity. Previous studies have shown that activation of the nuclear peroxisome proliferator activated receptor-alpha (PPAR{alpha}) is required for this effect. The present study utilizes gene expression profile analysis to identify potential pathways contributing to PPAR{alpha}-mediated hepatoprotection. Gene expression profiles were compared between wild type and PPAR{alpha}-null mice pretreated with vehicle or CFB (500 mg/kg, i.p., daily for 10 days) and then challenged with APAP (400 mg/kg, p.o.). Total hepatic RNA was isolated 4 h after APAP treatment and hybridized to Affymetrix Mouse Genome MGU74 v2.0 GeneChips. Gene expression analysis was performed utilizing GeneSpring (registered) software. Our analysis identified 53 genes of interest including vanin-1, cell cycle regulators, lipid-metabolizing enzymes, and aldehyde dehydrogenase 2, an acetaminophen binding protein. Vanin-1 could be important for CFB-mediated hepatoprotection because this protein is involved in the synthesis of cysteamine and cystamine. These are potent antioxidants capable of ameliorating APAP toxicity in rodents and humans. HPLC-ESI/MS/MS analysis of liver extracts indicates that enhanced vanin-1 gene expression results in elevated cystamine levels, which could be mechanistically associated with CFB-mediated hepatoprotection.

Moffit, Jeffrey S. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States); Koza-Taylor, Petra H. [Pfizer, Inc., Groton Laboratories, Molecular and Investigative Toxicology, Groton, CT (United States); Holland, Ricky D. [National Center for Toxicological Research, Division of Systems Toxicology, Jefferson, AR (United States); Thibodeau, Michael S. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States); Beger, Richard D. [National Center for Toxicological Research, Division of Systems Toxicology, Jefferson, AR (United States); Lawton, Michael P. [Pfizer, Inc., Groton Laboratories, Molecular and Investigative Toxicology, Groton, CT (United States); Manautou, Jose E. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States)]. E-mail: jose.manautou@uconn.edu

2007-07-15T23:59:59.000Z

409

Molecular dissection of the roles of the SOD genes in mammalian response to low dose irradiation  

SciTech Connect (OSTI)

It has been long recognized that a significant fraction of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying enzymes may be even more prominent in the case of low-dose, low-LET irradiation, as the majority of genetic damage may be caused by secondary oxidative species. In this study we have attempted to decipher the roles of the superoxide dismutase (SOD) genes, which are responsible for detoxifying the superoxide anions. We used adenovirus vectors to deliver RNA interference (RNAi or siRNA) technology to down-regulate the expression levels of the SOD genes. We have also over-expressed the SOD genes by use of recombinant adenovirus vectors. Cells infected with the vectors were then subjected to low dose ?-irradiation. Total RNA were extracted from the exposed cells and the expression of 9000 genes were profiled by use of cDNA microarrays. The result showed that low dose radiation had clear effects on gene expression in HCT116 cells. Both over-expression and down-regulation of the SOD1 gene can change the expression profiles of sub-groups of genes. Close to 200 of the 9000 genes examined showed over two-fold difference in expression under various conditions. Genes with changed expression pattern belong to many categories that include: early growth response, DNA-repair, ion transport, apoptosis, and cytokine response.

Eric Y. Chuang

2006-08-31T23:59:59.000Z

410

Identification of human metapneumovirus-induced gene networks in airway epithelial cells by microarray analysis  

SciTech Connect (OSTI)

Human metapneumovirus (hMPV) is a major cause of lower respiratory tract infections in infants, elderly and immunocompromised patients. Little is known about the response to hMPV infection of airway epithelial cells, which play a pivotal role in initiating and shaping innate and adaptive immune responses. In this study, we analyzed the transcriptional profiles of airway epithelial cells infected with hMPV using high-density oligonucleotide microarrays. Of the 47,400 transcripts and variants represented on the Affimetrix GeneChip Human Genome HG-U133 plus 2 array, 1601 genes were significantly altered following hMPV infection. Altered genes were then assigned to functional categories and mapped to signaling pathways. Many up-regulated genes are involved in the initiation of pro-inflammatory and antiviral immune responses, including chemokines, cytokines, type I interferon and interferon-inducible proteins. Other important functional classes up-regulated by hMPV infection include cellular signaling, gene transcription and apoptosis. Notably, genes associated with antioxidant and membrane transport activity, several metabolic pathways and cell proliferation were down-regulated in response to hMPV infection. Real-time PCR and Western blot assays were used to confirm the expression of genes related to several of these functional groups. The overall result of this study provides novel information on host gene expression upon infection with hMPV and also serves as a foundation for future investigations of genes and pathways involved in the pathogenesis of this important viral infection. Furthermore, it can facilitate a comparative analysis of other paramyxoviral infections to determine the transcriptional changes that are conserved versus the one that are specific to individual pathogens.

Bao, X. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States); Sinha, M. [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas (United States)]|[UTMB Bioinformatics Program, University of Texas Medical Branch, Galveston, Texas (United States); Liu, T.; Hong, C. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States); Luxon, B.A. [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas (United States)]|[UTMB Bioinformatics Program, University of Texas Medical Branch, Galveston, Texas (United States); Garofalo, R.P. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States)]|[Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas (United States)]|[Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas (United States); Casola, A. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States)]|[Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas (United States)]|[Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas (United States)], E-mail: ancasola@utmb.edu

2008-04-25T23:59:59.000Z

411

Barbara McClintock, Jumping Genes, and Transposition  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Barbara McClintock and Transposable Genetic Elements McClintock Honored · Woman of Science · Educational Material · Resources with Additional Information Barbara McClintock's remarkable life spanned the history of genetics in the twentieth century. ... [T]he science of genetics, to which McClintock made seminal contributions both experimental and conceptual, has come to dominate all of the biological sciences, from molecular biology, through cell and developmental biology, to medicine and agriculture. ... Barbara McClintock Courtesy of the Cold Spring Harbor Laboratory Archives McClintock made her first significant contribution as a graduate student, developing cytological techniques that allowed her to identify each of the ten maize chromosomes. These early experiments laid the groundwork for a remarkable series of cytogenetic discoveries ... [for which] McClintock was the intellectual driving force ... . These include identification of maize linkage groups with individual chromosomes, the well-known cytological proof of genetic crossing-over, evidence of chromatid crossing-over, cytological determination of the physical location of genes within chromosomes, identification of the genetic consequences of nonhomologous pairing, establishment of the causal relationship between the instability of ring-shaped chromosomes and phenotypic variegation, discovery that the centromere is divisible, and identification of a chromosomal site essential for the formation of the nucleolus. ...

412

Scalable Dynamic Instrumentation for BlueGene/L  

SciTech Connect (OSTI)

Dynamic binary instrumentation for performance analysis on new, large scale architectures such as the IBM Blue Gene/L system (BG/L) poses new challenges. Their scale--with potentially hundreds of thousands of compute nodes--requires new, more scalable mechanisms to deploy and to organize binary instrumentation and to collect the resulting data gathered by the inserted probes. Further, many of these new machines don't support full operating systems on the compute nodes; rather, they rely on light-weight custom compute kernels that do not support daemon-based implementations. We describe the design and current status of a new implementation of the DPCL (Dynamic Probe Class Library) API for BG/L. DPCL provides an easy to use layer for dynamic instrumentation on parallel MPI applications based on the DynInst dynamic instrumentation mechanism for sequential platforms. Our work includes modifying DynInst to control instrumentation from remote I/O nodes and porting DPCL's communication to use MRNet, a scalable data reduction network for collecting performance data. We describe extensions to the DPCL API that support instrumentation of task subsets and aggregation of collected performance data. Overall, our implementation provides a scalable infrastructure that provides efficient binary instrumentation on BG/L.

Schulz, M; Ahn, D; Bernat, A; de Supinski, B R; Ko, S Y; Lee, G; Rountree, B

2005-09-08T23:59:59.000Z

413

Mapping Our Genes: The Genome Projects: How Big, How Fast  

DOE R&D Accomplishments [OSTI]

For the past 2 years, scientific and technical journals in biology and medicine have extensively covered a debate about whether and how to determine the function and order of human genes on human chromosomes and when to determine the sequence of molecular building blocks that comprise DNA in those chromosomes. In 1987, these issues rose to become part of the public agenda. The debate involves science, technology, and politics. Congress is responsible for ?writing the rules? of what various federal agencies do and for funding their work. This report surveys the points made so far in the debate, focusing on those that most directly influence the policy options facing the US Congress. Congressional interest focused on how to assess the rationales for conducting human genome projects, how to fund human genome projects (at what level and through which mechanisms), how to coordinate the scientific and technical programs of the several federal agencies and private interests already supporting various genome projects, and how to strike a balance regarding the impact of genome projects on international scientific cooperation and international economic competition in biotechnology. The Office of Technology Assessment (OTA) prepared this report with the assistance of several hundred experts throughout the world.

1988-04-00T23:59:59.000Z

414

EarlyExperienceOnBlueGeneQ.pptx  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Performance Engineering Team Early Experience on the Blue Gene/Q Supercomputing System Mira P erformance B oot C amp Argonne, M ay 2 1, 2 013 Argonne L eadership C ompuDng F acility Argonne N aDonal L aboratory, A rgonne, I L 2 Outline  Introduc+on - Argonne L eadership C ompu+ng F acility - From B G/P t o B G/Q  BG/Q S ystem C haracteris+cs - Memory S ubsystem - Computa+on C apabili+es - Interconnect a nd C ommunica+on P roper+es - Power C onsump+on a nd E fficiency  BG/Q S pecific F eatures - QPX --- 4 ---way S IMD V ector U nit - Prefetching U nit a nd L ist P refetching  Applica+on S tudies - GTC, G FMC, D NS3D ALCF @ Argonne 3 Produc'on S ystems: Mira - B G/Q s ystem - 49,152 nodes / 786,432 cores - 786 TB of memory - Peak fl op r ate: 1 0 P F - Linpack fl op r ate: 8 .1 P F Intrepid

415

An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes  

Science Journals Connector (OSTI)

Receptor-mediated gene transfer is an attractive method for therapeutically correcting human genetic diseases since it permits the targeting of DNA to cellular receptors in specific tissues of adult animals. G...

Jose C. Perales; Thomas Ferkol; Maria Molas; Richard W. Hanson

1995-01-01T23:59:59.000Z

416

Depression of Protein Synthetic Capacity Due to Cloned-Gene Expression in E. coli  

E-Print Network [OSTI]

Depression of Protein Synthetic Capacity Due to Cloned-Gene Expression in E. coli Thomas K. Wood using pulse-labelling and RNA-DNA hybridiza- tions. Specifically, the steady-state level, synthesis rate

Wood, Thomas K.

417

Gene Designer: a synthetic biology tool for constructing artificial DNA segments  

Science Journals Connector (OSTI)

Gene Designer is a stand-alone software for fast and easy design of synthetic DNA segments. Users can easily add, edit ... drag-and-drop graphic interface and a hierarchical DNA/Protein object map. Using advanced...

Alan Villalobos; Jon E Ness; Claes Gustafsson; Jeremy Minshull

2006-06-01T23:59:59.000Z

418

E-Print Network 3.0 - anti-cancer target gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: anti-cancer target gene Page: << < 1 2 3 4 5 > >> 1 THE BETTER WORLD REPORT PART TWO Biotechnology...

419

Kiss1 Gene Expression and the Effects of Kisspeptin During Pubertal Development in the Ewe Lamb  

E-Print Network [OSTI]

puberty. In Experiment 1, ovariectomized ewe lambs bearing subcutaneous estradiol implants were used to investigate Kiss1 gene expression in the preoptic area (POA) and hypothalamus during pubertal maturation of the reproductive neuroendocrine system...

Redmond, Jeremy Scott

2012-02-14T23:59:59.000Z

420

Ebola virus RNA editing:Characterization of the mechanism and gene products.  

E-Print Network [OSTI]

??Ebola virus (EBOV) is an enveloped, negative-sense single-stranded RNA virus that causes severe hemorrhagic fever in humans and nonhuman primates. The EBOV glycoprotein (GP) gene (more)

Mehedi, Masfique

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Fitting It All Together: How Courtship- and Mating-Responsive Genes Affect Drosophila melanogaster Male Behavior  

E-Print Network [OSTI]

by utilizing microarray technology to assess courtship- or mating-induced gene expression changes in Drosophila male whole bodies or heads. Mutations in candidate loci were tested for effects on reproductive behaviors and present the first data showing...

Ellis, Lisa Lynn

2011-10-21T23:59:59.000Z

422

Novel enabling technologies of gene isolation and plant transformation for improved crop protection  

SciTech Connect (OSTI)

Meeting the needs of agricultural producers requires the continued development of improved transgenic crop protection products. The completed project focused on developing novel enabling technologies of gene discovery and plant transformation to facilitate the generation of such products.

Torok, Tamas

2013-02-04T23:59:59.000Z

423

Molecular cloning and characterization of important stress and redox regulatory genes from Hydra vulgaris  

E-Print Network [OSTI]

In this research, important stress and redox regulatory genes present in Hydra vulgaris were isolated and characterized to facilitate our understanding of the evolution and mechanisms of stress response. H. vulgaris heat shock protein 70 (HvHSP70...

Dash, Bhagirathi

2007-04-25T23:59:59.000Z

424

The MORPH Algorithm: Ranking Candidate Genes for Membership in Arabidopsis and Tomato Pathways  

Science Journals Connector (OSTI)

...established in machine learning and is sometimes...Hence, in plant model organisms...context of disease gene learning...tools for plant biology...caveats. Plant Cell Environ...Conference on Machine Learning (ICML...function prediction from heterogeneous...

Oren Tzfadia; David Amar; Louis M.T. Bradbury; Eleanore T. Wurtzel; Ron Shamir

2012-11-30T23:59:59.000Z

425

Selection and characterization of alpha-amylase-overproducing recombinant Escherichia coli containing the bacterial hemoglobin gene  

Science Journals Connector (OSTI)

We previously reported that the presence of the bacterial (Vitreoscilla) hemoglobin gene enhances alpha-amylase production in recombinant Escherichia coli...strain MK79. Using the growth of MK79 on starch as a se...

Shie-Chau Liu; Besim Ogretmen; Yao-Yu Chuang

1992-11-01T23:59:59.000Z

426

Maize Opaque Endosperm Mutations Create Extensive Changes in Patterns of Gene Expression  

Science Journals Connector (OSTI)

...outside of this phenotypically correlated cluster should be additive. However, if the basis of the mutant phenotype is zein...image was inspected visually for hybridization artifacts and manufacturing defects. Maize GeneChip Design and Data Analysis The maize...

Brenda G. Hunter; Mary K. Beatty; George W. Singletary; Bruce R. Hamaker; Brian P. Dilkes; Brian A. Larkins; Rudolf Jung

2002-09-26T23:59:59.000Z

427

Regulation of horizontal gene transfer by intercellular peptide signaling in Bacillus subtilis  

E-Print Network [OSTI]

Horizontal gene transfer plays an important role in bacterial evolution. Although acquisition of foreign DNA can be beneficial to cells, it can also be detrimental. Therefore, cells that possess mechanisms to regulate ...

Auchtung, Jennifer M

2006-01-01T23:59:59.000Z

428

Parallels between UNUSUAL FLORAL ORGANS and FIMBRIATA, genes controlling flower development in Arabidopsis and Antirrhinum.  

Science Journals Connector (OSTI)

...United Kingdom The unusual floral organs (ufo) mutant of Arabidopsis has flowers with...To determine the relationship between UFO and previously characterized meristem and organ identity genes, we cloned UFO and determined its expression pattern...

429

Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability  

E-Print Network [OSTI]

Degradable, cationic poly(?-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency ...

Eltoukhy, Ahmed A.

430

E-Print Network 3.0 - acid inducible gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

contrasts fragile codon usage and fragile amino-acid usage in single-exon genes and multi- exon... in mammals (synonymous codon usage and amino-acid usage) can also be ......

431

Discovery of Genes and Genomes through Deep Metagenomic Sequencing of Cow Rumen (2010 JGI User Meeting)  

ScienceCinema (OSTI)

Director Eddy Rubin on "Discovery of Genes and Genomes through Deep Metagenomic Sequencing of Cow Rumen" on March 25, 2010 at the 5th Annual DOE JGI User Meeting

Rubin, Eddy

2011-04-25T23:59:59.000Z

432

Sequence and expression analysis of the gene encoding inducible cAMP early repressor in tilapia  

Science Journals Connector (OSTI)

Montriminy et al. [15] and Yamamoto et al. [16] reported cAMP response element binding protein (CREB) in eightieth last century. Because CREB can regulate multiple gene transcription ... is represented in many as...

Ming Chen; Rui Wang; Xi Gan; Aiying Lei; Chao Li; Xiaoli Yu

2010-06-01T23:59:59.000Z

433

Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and nonparallel physiological  

E-Print Network [OSTI]

of parallel and nonparallel physiological divergence M. L. EVANS* & L. BERNATCHEZ Institut de Biologie Inte: Coregonus; gene transcription; metabolism; oxidative phosphorylation; phenotypic divergence; physiology mitochondrial and nuclear genome-encoded oxidative phosphorylation (OXPHOS) complexes, the primary physiological

Bernatchez, Louis

434

Codon usage divergence of homologous vertebrate genes and codon usage clock  

Science Journals Connector (OSTI)

This paper is concerned with the divergence of synonymous codon usage and its bias in three homologous genes ... species are described in terms of synonymous codon usage divergence and the correlation is found be...

Manyuan Long; John H. Gillespie

1991-01-01T23:59:59.000Z

435

MosaicFinder: identification of fused gene families in sequence similarity networks  

Science Journals Connector (OSTI)

......priori distinction between a dataset in which fused genes are searched for, and a dataset that may have provided genetic...automatic analyses of big datasets. We implemented this method...phospholipid synthesis, nuclear export and surface antigen......

Pierre-Alain Jachiet; Romain Pogorelcnik; Anne Berry; Philippe Lopez; Eric Bapteste

2013-04-01T23:59:59.000Z

436

Identification of sensitivity genes involved in teratogen-induced neural tube defects  

E-Print Network [OSTI]

that NTDs have a strong genetic component to their development. My project is designed to examine differential expression patterns of genes within the neural tube cells of inbred LM/Bc mouse fetuses following exposure to the known teratogenic agent...

Hayes, Blaine G

2013-02-22T23:59:59.000Z

437

E-Print Network 3.0 - alkane 1-monooxygenase gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ISOLATION IS DETERMINED BY LARVAL Summary: , ranging from C29 to C41, were recovered by gas chromatography that represented major classes of alkanes... in the reduction of gene...

438

E-Print Network 3.0 - antitrypsin serpina1 gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

profiles in human epithelial cells Summary: G 6.83 1.21 + L15702 Complement factor B CFB 4.45 1.18 + X01683 Alpha-1-antitrypsin SERPINA1 2... parthenolide on gene transcription...

439

Transcriptional insulation of the human keratin 18 gene in transgenic mice.  

Science Journals Connector (OSTI)

...research-article Research Article Transcriptional insulation of the human keratin 18 gene in transgenic...for this property of transcriptional insulation, additional transgenic mouse lines...sequence requirements for transcriptional insulation in adult liver and intestine are different...

N Neznanov; I S Thorey; G Cecea; R G Oshima

1993-04-01T23:59:59.000Z

440

E-Print Network 3.0 - affecting demethylation-induced gene Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 34 PLoS Biology | www.plosbiology.org 0001 In humanpathogen encounters,the battle for advantage Summary: out at the level of gene expression.Hosts will stand a...

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

E-Print Network 3.0 - aopex11-1 gene involved Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sciences 48 PLoS Biology | www.plosbiology.org 0001 In humanpathogen encounters,the battle for advantage Summary: out at the level of gene expression.Hosts will stand a...

442

Genes related to xylose fermentation and methods of using same for enhanced biofuel production  

DOE Patents [OSTI]

The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided.

Wohlbach, Dana J.; Gasch, Audrey P.

2014-08-05T23:59:59.000Z

443

E-Print Network 3.0 - abl fusion gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Engineering ; Computer Technologies and Information Sciences 2 Materials needed Primer A Gene specific sense (21-24bp); 2-3Kb from start ATG Summary: PCR fusion Materials...

444

Linking Advanced Visualization and MATLAB for the Analysis of 3D Gene Expression Data  

Science Journals Connector (OSTI)

Three-dimensional gene expression PointCloud data generated by the Berkeley Drosophila TranscriptionNetwork Project (BDTNP) provides quantitative information about the...Drosophila...embryos at cellular resolutio...

Oliver Rbel; Soile V. E. Kernen

2012-01-01T23:59:59.000Z

445

Knowledge acquisition, consistency checking and concurrency control for Gene Ontology (GO)  

Science Journals Connector (OSTI)

......University Press 2003 Original Paper Knowledge acquisition, consistency checking and...for communicating biological data and knowledge. The Gene Ontology (GO; http...paper, we assess the applicability of a Knowledge Base Management System (KBMS), Protege-2000......

Iwei Yeh; Peter D. Karp; Natalya F. Noy; Russ B. Altman

2003-01-01T23:59:59.000Z

446

Knowledge-based computational search for genes associated with the metabolic syndrome  

Science Journals Connector (OSTI)

......ORIGINAL PAPERS Data and text mining Knowledge-based computational search for genes...integrating the large amount of accumulated knowledge is seriously needed. A comprehensive...validity was confirmed by comparing the knowledge extracted by the ordering with existing......

Tsutomu Matsunaga; Masa-aki Muramatsu

2005-07-01T23:59:59.000Z

447

E-Print Network 3.0 - a-complementing xpac gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Johns Hopkins... ,000 genes. See also R.M. Henig's book The Monk in the Garden: The Lost and Found Genius of Gregor Mendel Source: Le Roy, Robert J. - Department of...

448

The compact Selaginella genome identifies changes in gene content associated with the evolution of vascular plants  

SciTech Connect (OSTI)

We report the genome sequence of the nonseed vascular plant, Selaginella moellendorffii, and by comparative genomics identify genes that likely played important roles in the early evolution of vascular plants and their subsequent evolution

Grigoriev, Igor V.; Banks, Jo Ann; Nishiyama, Tomoaki; Hasebe, Mitsuyasu; Bowman, John L.; Gribskov, Michael; dePamphilis, Claude; Albert, Victor A.; Aono, Naoki; Aoyama, Tsuyoshi; Ambrose, Barbara A.; Ashton, Neil W.; Axtell, Michael J.; Barker, Elizabeth; Barker, Michael S.; Bennetzen, Jeffrey L.; Bonawitz, Nicholas D.; Chapple, Clint; Cheng, Chaoyang; Correa, Luiz Gustavo Guedes; Dacre, Michael; DeBarry, Jeremy; Dreyer, Ingo; Elias, Marek; Engstrom, Eric M.; Estelle, Mark; Feng, Liang; Finet, Cedric; Floyd, Sandra K.; Frommer, Wolf B.; Fujita, Tomomichi; Gramzow, Lydia; Gutensohn, Michael; Harholt, Jesper; Hattori, Mitsuru; Heyl, Alexander; Hirai, Tadayoshi; Hiwatashi, Yuji; Ishikawa, Masaki; Iwata, Mineko; Karol, Kenneth G.; Koehler, Barbara; Kolukisaoglu, Uener; Kubo, Minoru; Kurata, Tetsuya; Lalonde, Sylvie; Li, Kejie; Li, Ying; Litt, Amy; Lyons, Eric; Manning, Gerard; Maruyama, Takeshi; Michael, Todd P.; Mikami, Koji; Miyazaki, Saori; Morinaga, Shin-ichi; Murata, Takashi; Mueller-Roeber, Bernd; Nelson, David R.; Obara, Mari; Oguri, Yasuko; Olmstead, Richard G.; Onodera, Naoko; Petersen, Bent Larsen; Pils, Birgit; Prigge, Michael; Rensing, Stefan A.; Riano-Pachon, Diego Mauricio; Roberts, Alison W.; Sato, Yoshikatsu; Scheller, Henrik Vibe; Schulz, Burkhard; Schulz, Christian; Shakirov, Eugene V.; Shibagaki, Nakako; Shinohara, Naoki; Shippen, Dorothy E.; Sorensen, Iben; Sotooka, Ryo; Sugimoto, Nagisa; Sugita, Mamoru; Sumikawa, Naomi; Tanurdzic, Milos; Theilsen, Gunter; Ulvskov, Peter; Wakazuki, Sachiko; Weng, Jing-Ke; Willats, William W.G.T.; Wipf, Daniel; Wolf, Paul G.; Yang, Lixing; Zimmer, Andreas D.; Zhu, Qihui; Mitros, Therese; Hellsten, Uffe; Loque, Dominique; Otillar, Robert; Salamov, Asaf; Schmutz, Jeremy; Shapiro, Harris; Lindquist, Erika; Lucas, Susan; Rokhsar, Daniel

2011-04-28T23:59:59.000Z

449

Fidelity of Histone Gene Regulation Is Obligatory for Genome Replication and Stability  

Science Journals Connector (OSTI)

...gene expression and DNA replication. A fundamental and unresolved question is the mechanism...phosphatase C inhibitor calyculin A to force chromosomes to condense during interphase...ed), Cell biology: a laboratory handbook, 3rd ed, vol 1 . Elsevier Academic...

Prachi N. Ghule; Rong-Lin Xie; Ricardo Medina; Jennifer L. Colby; Stephen N. Jones; Jane B. Lian; Janet L. Stein; Andre J. van Wijnen; Gary S. Stein

2014-05-05T23:59:59.000Z

450

PLAZA: A Comparative Genomics Resource to Study Gene and Genome Evolution in Plants  

Science Journals Connector (OSTI)

...requires a centralized plant genomics infrastructure where all information generated by different...Vandepoele and Van de Peer, 2005) are hybrid systems integrating gene information...this genome information, a centralized infrastructure is required where all data generated...

Sebastian Proost; Michiel Van Bel; Lieven Sterck; Kenny Billiau; Thomas Van Parys; Yves Van de Peer; Klaas Vandepoele

2009-12-29T23:59:59.000Z

451

The Caenorhabditis elegans Gene mfap-1 Encodes a Nuclear Protein That Affects Alternative Splicing  

E-Print Network [OSTI]

RNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single premRNA, alternative splicing plays a key role in promoting the evolving complexity ...

Horvitz, H Robert

452

E-Print Network 3.0 - alpha -subunit gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Manual Introduction Summary: Networks (TRN) by integrating gene expression data with ChIP-on-chip or motif binding information. The main... purpose of developing GibbsOS is to...

453

Arabidopsis Plastid AMOS1/EGY1 Integrates Abscisic Acid Signaling to Regulate Global Gene Expression  

E-Print Network [OSTI]

genes and maintains chloroplast functionality under NH4 + stress. Importantly, abi4 mutants defective and Kronzucker, 2002; von Wirén and Merrick, 2004). Extensive studies have been car- ried out that dissect

Kronzucker, Herbert J.

454

MyoD Gene Transfer for Cardiac Repair 2209 J. Clin. Invest.  

E-Print Network [OSTI]

the myogenic determination gene, MyoD, into cardiac granulation (wound repair) tissue. A replica- tion-defective suffer myocardial infarctions have significantly impaired car- diac function. Thus, therapy to induce

Kay, Mark A.

455

Correlations Between Gene Expression and Mercury Levels in Blood of Boys With and Without Autism  

E-Print Network [OSTI]

Ingenuity Pathways Analysis (IPA) (Ingenuity Systems ,ed the pathways from the IPA library of canonical pathwaysis not possible. In this case, IPA was used to map the genes

2011-01-01T23:59:59.000Z

456

Features of the ancestral bilaterian inferred from Platynereis dumerilii ParaHox genes  

Science Journals Connector (OSTI)

ParaHox genes in the ragworm, Platynereis, show a complexity of expression and a clustered arrangement not seen in other protostomes, supporting a reconstruction of the Parahox cluster in the extinct protostome-deuterostome ancestor.

Jerome HL Hui; Florian Raible; Natalia Korchagina; Nicolas Dray; Sylvie Samain; Ghislaine Magdelenat; Claire Jubin; Batrice Segurens; Guillaume Balavoine; Detlev Arendt; David EK Ferrier

2009-07-23T23:59:59.000Z

457

Validation and refinement of gene-regulatory pathways on a network of physical interactions  

E-Print Network [OSTI]

As genome-scale measurements lead to increasingly complex models of gene regulation, systematic approaches are needed to validate and refine these models. Towards this goal, we describe an automated procedure for prioritizing ...

Yeang, Chen-Hsiang, 1969-

458

E-Print Network 3.0 - aromatase gene defines Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

gene defines Page: << < 1 2 3 4 5 > >> 1 ORIGINAL ARTICLE Aromatase mRNA in the Brain of Adult Green Anole Lizards: Effects of Summary: to previous work using Nissl-stained...

459

E-Print Network 3.0 - aromatase gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

gene expression Page: << < 1 2 3 4 5 > >> 1 ORIGINAL ARTICLE Aromatase mRNA in the Brain of Adult Green Anole Lizards: Effects of Summary: of testosterone to oestradiol (E2)...

460

Subchromoplast Sequestration of Carotenoids Affects Regulatory Mechanisms in Tomato Lines Expressing Different Carotenoid Gene Combinations  

Science Journals Connector (OSTI)

...replicates. The mean data are presented sd; CAR, carotenoid. Dunnetts test was used...corresponded to genes associated with alternative tissue-specific expression (Figure...thylakoid biogenesis machinery and elevated energy-production components. Plant Physiol...

Marilise Nogueira; Leticia Mora; Eugenia M.A. Enfissi; Peter M. Bramley; Paul D. Fraser

2013-11-18T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism  

E-Print Network [OSTI]

The effects of adiponectin on hepatic glucose and lipid metabolism at transcriptional level are largely unknown. We profiled hepatic gene expression in adiponectin knockout (KO) and wild-type (WT) mice by RNA sequencing. ...

Liu, Qingqing

462

Arrangement of ribosomal genes in nucleolar domains revealed by detection of "Christmas tree" components  

Science Journals Connector (OSTI)

...We investigated how the transcribing ribosomal genes ("Christmas trees") of HeLa cells are arranged ... used immunocytochemistry and in situ hybridisation at the light microscopic and ultrastructural level for...

Wilhelm Mosgoeller; Christian Schfer; Marianne Steiner

2001-12-01T23:59:59.000Z

463

E-Print Network 3.0 - activity mia-like gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

: Castillo-Davis, C. I. and D. L. Hartl. 2003. GeneMerge-- post-genomic analysis, data-mining and hypothesis... testing. Bioinformatics 19(7):891-892 http:www.oeb.harvard.edu...

464

Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut  

Science Journals Connector (OSTI)

Several hereditary syndromes characterized by defective DNA repair are associated with high risk of non-Hodgkin lymphoma (NHL). To explore whether common polymorphisms in DNA repair genes affect risk of NHL in th...

Min Shen; Tongzhang Zheng; Qing Lan; Yawei Zhang; Shelia H. Zahm

2006-07-01T23:59:59.000Z

465

The smallest genome RNA segment of influenza virus contains two genes that may overlap  

Science Journals Connector (OSTI)

...this RNA appears to be insufficient to code for both polypeptides independently, it seems likely that the NS1 and NS2 genes overlap. Furthermore, if, as...are completely unrelated, the genetic code of the shared nucleotide sequences would...

S C Inglis; T Barrett; C M Brown; J W Almond

1979-01-01T23:59:59.000Z

466

Modified cellulose synthase gene from 'Arabidopsis thaliana' confers herbicide resistance to plants  

SciTech Connect (OSTI)

Cellulose synthase ('CS'), a key enzyme in the biosynthesis of cellulose in plants is inhibited by herbicides comprising thiazolidinones such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl) phenyl-4-thiazolidinone (TZ), isoxaben and 2,6-dichlorobenzonitrile (DCB). Two mutant genes encoding isoxaben and TZ-resistant cellulose synthase have been isolated from isoxaben and TZ-resistant Arabidopsis thaliana mutants. When compared with the gene coding for isoxaben or TZ-sensitive cellulose synthase, one of the resistant CS genes contains a point mutation, wherein glycine residue 998 is replaced by an aspartic acid. The other resistant mutation is due to a threonine to isoleucine change at amino acid residue 942. The mutant CS gene can be used to impart herbicide resistance to a plant; thereby permitting the utilization of the herbicide as a single application at a concentration which ensures the complete or substantially complete killing of weeds, while leaving the transgenic crop plant essentially undamaged.

Somerville, Chris R.; Scieble, Wolf

2000-10-11T23:59:59.000Z

467

HUMAN GENE THERAPY 18:871880 (October 2007) Mary Ann Liebert, Inc.  

E-Print Network [OSTI]

HUMAN GENE THERAPY 18:871­880 (October 2007) © Mary Ann Liebert, Inc. DOI: 10.1089/hum.2007 of funda- mental questions in retinal biology. 871 INTRODUCTION RNA INTERFERENCE (RNAi) is an approach

Kay, Mark A.

468

Identifying genes that are required for the maintenance of pancreatic ductal adenocarcinoma  

E-Print Network [OSTI]

We searched for genes that are potentially important for the maintenance of Pancreatic Ductal Adenocarcinoma (PDAC). PDAC is the 4th leading cause for cancer-related deaths and exhibits a 5-year survival rate of less than ...

Jenq, Harry

2012-01-01T23:59:59.000Z

469

Nanoparticle-Delivered Suicide Gene Therapy Effectively Reduces Ovarian Tumor Burden in Mice  

Science Journals Connector (OSTI)

...Molecular Targets, and Chemical Biology Nanoparticle-Delivered Suicide Gene Therapy Effectively...treatment with nanoparticles. DT-A nanoparticle therapy suppressed tumor growth more...indicating MSLN promoter function following nanoparticle delivery of DNA (Fig. 1E ). Xenograft...

Yu-Hung Huang; Gregory T. Zugates; Weidan Peng; David Holtz; Charles Dunton; Jordan J. Green; Naushad Hossain; Michael R. Chernick; Robert F. Padera, Jr.; Robert Langer; Daniel G. Anderson; Janet A. Sawicki

2009-08-01T23:59:59.000Z

470

E-Print Network 3.0 - adenovirus-mediated gene transfer Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

67 Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki Summary: , Stricker H, Pegg J et al. Phase I study of replica- tion-competent adenovirus-mediated...

471

E-Print Network 3.0 - affects odontoblast gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: mice expression of the other non-targeted Runx genes is not affected (Stricker et al., 2002; Yamashiro... in these epithelia is regulated by TGF-b is an interesting...

472

E-Print Network 3.0 - adenovirus-mediated gene delivery Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

58 Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki Summary: , Stricker H, Pegg J et al. Phase I study of replica- tion-competent adenovirus-mediated...

473

A fast, robust and tunable synthetic gene oscillator Jesse Stricker1  

E-Print Network [OSTI]

LETTERS A fast, robust and tunable synthetic gene oscillator Jesse Stricker1 *, Scott Cookson1 *, Matthew R. Bennett1,2 *, William H. Mather1 , Lev S. Tsimring2 & Jeff Hasty1,2 One defining goal

Hasty, Jeff

474

Effects of Dietary Energy Restriction on Gene Regulation in Mammary Epithelial Cells  

Science Journals Connector (OSTI)

...Prevention Effects of Dietary Energy Restriction on Gene Regulation...determine whether dietary energy restriction (DER) affects...breast cancer research. New York: Kluwer Academic/Plenum...HJ. Effects of dietary energy repletion and IGF-1 infusion...

Zongjian Zhu; Weiqin Jiang; John N. McGinley; Jennifer M. Price; Bifeng Gao; and Henry J. Thompson

2007-12-15T23:59:59.000Z

475

Rh-Gene Frequencies in Pygmies (Batswa) of the Belgian Congo  

Science Journals Connector (OSTI)

... ninety-four bloods withdrawn from pygmies (Batswa) of the Equatorial Province, in the Belgian Congo. The gene frequencies for ABO and MN systems approximated to 1 (D/? values ...

PIERRE O. HUBINONT; JEAN SNOECK

1949-08-20T23:59:59.000Z

476

E-Print Network 3.0 - adeno-associated virus gene Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(AAV) for expressing short hairpin RNA (sh... the human immunodeficiency virus type 1 (HIV-1) tat gene and the NF-B p65 subunit, respectively. 23 adeno-associated... 23...

477

A New Approach to Antiviral Chemotherapy: Intervention in Viral Gene Expression by HIV Tat Antagonists  

Science Journals Connector (OSTI)

One area in which molecular virology has made major advances seems largely to have escaped the attention of pharmacologists. This is the study of how viruses regulate their gene expression. Advances in this ar...

Ming-Chu Hsu; Steve Tam

1993-01-01T23:59:59.000Z

478

Examination of dioxin and its alteration of gene expression via DNA Microarray Analysis  

E-Print Network [OSTI]

), and ADD/ADHD. Little evidence has been available to demonstrate how dioxin specifically alters gene expression, both in developing embryos and adults. Recently, Texas A&M University has acquired several DNA Microarray Systems, which are revolutionizing...

Wright, Justin Charles

2013-02-22T23:59:59.000Z

479

Discovery of apoptotic genes in the genome-wide study of doxorubicin resistance in cancer treatment  

Science Journals Connector (OSTI)

...of gene expression might contribute directly to promotion of metastasis. Metastasis is a complex process involving sequential and interrelated steps. In this study, we have examined the impact of EWS/FLI expression on cell migration, cell...

Irada Ibrahim-zada; Hamdi Jarjanazi; Sevtap Savas; Kathleen Pritchard; Laurent Briollais; and Hilmi Ozcelik

2008-05-01T23:59:59.000Z

480

Identification of effective leaf-rust resistance genes in wheat (Triticum aestivum) using STS markers  

Science Journals Connector (OSTI)

Molecular STS markers J13, Gb, and J09 were used for screening wheat (Triticum aestivum L.) accessions previously found to possess leaf-rust resistance genes according to test crosses or phytopathological tests. ...

L. G. Tyryshkin; E. I. Gultyaeva; N. V. Alpateva

2006-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "jacobsen gene polik" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Cytotoxic T-Lymphocyte Antigen 4 Gene and Recovery from Hepatitis B Virus Infection  

Science Journals Connector (OSTI)

...4 Gene and Recovery from Hepatitis...Diversity, National Cancer Institute...influences recovery from HBV infection...institutional review boards at all participating...associated with recovery, by ethnicity...funded by the National Institute of...

Chloe L. Thio; Timothy L. Mosbruger; Richard A. Kaslow; Christopher L. Karp; Steffanie A. Strathdee; David Vlahov; Stephen J. O'Brien; Jacquie Astemborski; David L. Thomas

2004-10-01T23:59:59.000Z

482

Scientific Methods Workshop: Ecological and Agronomic Consequences of Gene Flow from  

E-Print Network [OSTI]

Scientific Methods Workshop: Ecological and Agronomic Consequences of Gene Flow from Transgenic Prevention Division, U.S. EPA" Robert Zemetra, University of Idaho 178 "The evolution of a biological risk

Snow, Allison A.

483

A Transient Transgenic RNAi Strategy for Rapid Characterization of Gene Function during Embryonic Development  

E-Print Network [OSTI]

RNA interference (RNAi) is a powerful strategy for studying the phenotypic consequences of reduced gene expression levels in model systems. To develop a method for the rapid characterization of the developmental consequences ...

Bjork, Bryan C.

484

Palindromes on the human X chromosome : testis-biased transcription, gene conversion and evolution  

E-Print Network [OSTI]

Recent genomic studies of the Y chromosome revealed massive, testis-specific palindromes that span 30% of the chromosome and are subject to gene conversion. We conducted studies to determine whether similar palindromes ...

Saionz, Jennifer R., 1976-

2005-01-01T23:59:59.000Z

485

Identifying protein-coding genes and synonymous constraint elements using phylogenetic codon models  

E-Print Network [OSTI]

We develop novel methods for comparative genomics analysis of protein-coding genes using phylogenetic codon models, in pursuit of two main lines of biological investigation: First, we develop PhyloCSF, an algorithm based ...

Lin, Michael F. (Michael Fong-Jay)

2012-01-01T23:59:59.000Z

486

Effect of random and hub gene disruptions on environmental and mutational robustness in Escherichia coli  

Science Journals Connector (OSTI)

Genome-wide profiling has allowed the regulatory interaction networks of many organisms to be visualised and the pattern of connections between genes to be studied. These networks are non-random, following a p...

Tim F Cooper; Andrew P Morby; Annabel Gunn; Dominique Schneider

2006-09-01T23:59:59.000Z

487

Powered by NERSC, A Database of Billions of Genes and Counting!  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Powered by NERSC, a Powered by NERSC, a Database of Billions of Genes and Counting! Powered by NERSC, a Database of Billions of Genes and Counting! With More than a Billion Microbial genes, IMG/M Breaks a Record January 26, 2012 | Tags: Joint Genome Institute Linda Vu, lvu@lbl.gov, +1 510 495 2402 IMG/M team celebrates the recording of 1 billionth gene. Microbes are microscopic organisms that live in every nook and cranny of our planet. Without them, plants wouldn't grow, garbage wouldn't decay, humans wouldn't digest food, and there would literally be no life on Earth, or at least as we know it. By examining the genetic makeup of these "bugs," scientists hope to understand how they work, and how they can be used to solve a variety of important problems like identifying new

488

E-Print Network 3.0 - anaerobic gene expression Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Medicine 15 Proc. Natl. Acad. Sci. USA Vol. 93, pp. 3575-3580, April 1996 Summary: and environmental regulation of nitro- genase gene expression and enzyme activity would expand...

489

Biomedical data retrieval utilizing textual data in a gene expression database by Richard Lu, MD.  

E-Print Network [OSTI]

Background: The commoditization of high-throughput gene expression sequencing and microarrays has led to a proliferation in both the amount of genomic and clinical data that is available. Descriptive textual information ...

Lu, Richard, M.D

2010-01-01T23:59:59.000Z

490

A role for the Spemann organizer gene, Goosecoid, in tumor metastasis  

E-Print Network [OSTI]

The process of invasion and metastasis during tumor progression is often reminiscent of cell migration events occurring during embryonic development. I hypothesized that genes controlling cellular changes in the Spemann ...

Hartwell, Kimberly A. (Kimberly Ann)

2007-01-01T23:59:59.000Z

491

Modeling the Fitness Consequences of a Cyanophage-Encoded Photosynthesis Gene  

E-Print Network [OSTI]

Background: Phages infecting marine picocyanobacteria often carry a psbA gene, which encodes a homolog to the photosynthetic reaction center protein, D1. Host encoded D1 decays during phage infection in the light. Phage ...

Chisholm, Sallie (Penny)

492

Molecular biology of Lea genes of higher plants  

SciTech Connect (OSTI)

This report contains our progress to date in determining the function of the D-7 Lea proteins in cotton embryos. We have completely sequenced the D-7 gene and established {ital E. coli} transformants which synthesize reasonable amounts of the D-7 protein. Two-dimensional electrophoresis was required to assay fractions for D-7 protein during purification to homogeneity, since D-7 has no known enzymatic activity, contains no Trp, and little Phe or Tyr, and {ital E. coli} has several proteins of similar molecular weight to D-7. Purified D-7 was used to generate monospecific antibodies which are being used for determination of the cellular distribution of D-7, and also for exact quantitation of D-7 in late-stage cotton embryos. Computerized modelling of D-7 has shown similarities to proteins with a coiled-coil structure, but fitting D-7 to this structure resulted in a violation of the handedness rule. If the pitch of the helix is changed from 3.6 to 3.667, however, a three dimensional structure (not a coiled coil) is generated which has overall energetics of formation nearly as favorable as the traditional {alpha} helix. The driving force for the change in pitch is proposed to result from favorable energetics of dimerization. Preliminary evidence indicates that D-7 does indeed dimerize in solution. Future experiments will determine the exact 3D structure of D-7 and the related protein D-29, as well as test the hypothesis that D-7 and D-29 are involved in mitigating dehydration of embryos and plants through sequestering phosphate or other ions in sufficient quantity to prevent ion precipitation or crystallization. 13 refs., 3 figs. (MHB)

Not Available

1991-07-01T23:59:59.000Z

493

Patterns and Implications of Gene Gain and Loss in the Evolution of Prochlorococcus  

SciTech Connect (OSTI)

Prochlorococcus is a marine cyanobacterium that numerically dominates the mid-latitude oceans and is the smallest known oxygenic phototroph. Numerous isolatesfrom diverse areas of the world's oceans have been studied and shown to be physiologically and genetically distinct. All isolates described thus far can be assigned to either a tightly clustered high-light (HL)-adapted clade, or a more divergent low-light (LL)-adapted group. The 16S rRNA sequences of the entire Prochlorococcus group differ by at most 3percent, and the four initially published genomes revealed patterns of genetic differentiation that help explain physiological differences among the isolates. Here we describe the genomes of eight newly sequenced isolates and combine them with the first four genomes for a comprehensive analysis of the core (shared by all isolates) and flexible genes of the Prochlorococcus group, and the patterns of loss and gain of the flexible genes over the course of evolution. There are 1,273 genes that represent the core shared by all 12 genomes. They are apparently sufficient, according to metabolic reconstruction, to encode a functional cell. We describe a phylogeny for all 12 isolates by subjecting their complete proteomes to three different phylogenetic analyses. For each non-core gene, we used a maximum parsimony method to estimate which ancestor likely first acquired or lost each gene. Many of the genetic differences among isolates, especially for genes involved in outer membrane synthesis and nutrient transport, are found within the same clade. Nevertheless, we identified some genes defining HL and LL ecotypes, and clades within these broad ecotypes, helping to demonstrate the basis of HL and LL adaptations in Prochlorococcus. Furthermore, our estimates of gene gain events allow us to identify highly variable genomic islands that are not apparent through simple pairwise comparisons. These results emphasize the functional roles, especially those connected to outer membrane synthesis and transport that dominate the flexible genome and set it apart from the core. Besides identifying islands and demonstrating their role throughout the history of Prochlorococcus, reconstruction of past gene gains and losses shows that much of the variability exists at the"leaves of the tree," between the most closely related strains. Finally, the identification of core and flexible genes from this 12-genome comparison is largely consistent with the relative frequency of Prochlorococcus genes found in global ocean metagenomic databases, further closing the gap between our understanding of these organisms in the lab and the wild.

Lapidus, Alla; Kettler, Gregory C.; Martiny, Adam C.; Huang, Katherine; Zucker, Jeremy; Coleman, Maureen L.; Rodrigue, Sebastien; Chen, Feng; Lapidus, Alla; Ferriera, Steven; Johnson, Justin; Steglich, Claudia; Church, George M.; Richardson, Paul; Chisholm, Sallie W.

2007-07-30T23:59:59.000Z

494

Molecular and cytological analysis of a novel leaf rust resistance gene in wheat  

E-Print Network [OSTI]

&M University in partial fulfillment of the requirements for the degree of MASTER QF SCIENCE Ap ved as to sibyl and content by: r g/Q Allan K. Fritz~ (Chair of Commit%+) David S. Marshall (Member) David M. Stelly (Member) Mark S. Hussey (Head... of Advisory Committee: Dr. Allan K. Fritz A novel wheat leaf rust resistance gene from Aegilops cylindricum accession TTCC295 was investigated, using both cytogenetic and molecular tools. Previous work had introgressed this gene in to adapted wheat...

Franks, Cleve Douglas

2012-06-07T23:59:59.000Z

495

Multiscale modeling and uncertainty quantification in nanoparticle-mediated drug/gene delivery  

Science Journals Connector (OSTI)

Nanoparticle (NP)-mediated drug/gene delivery involves phenomena at broad range spatial and temporal scales. The interplay between these phenomena makes the NP-mediated drug/gene delivery process very complex. In this paper, we have identified four key ... Keywords: Coarse-grained molecular dynamics, Drug delivery, Fluid-structure interaction, Immersed molecular electrokinetic finite element, Molecular mean-field theory, Multiscale modeling

Ying Li, Wylie Stroberg, Tae-Rin Lee, Han Sung Kim, Han Man, Dean Ho, Paolo Decuzzi, Wing Kam Liu

2014-03-01T23:59:59.000Z

496

[Enhancement of photoassimilate utilization by manipulation of ADP-glucose pyrophosphorylase gene]. Final progress report  

SciTech Connect (OSTI)

Part 1 of this research focuses on patterns of gene expression of ADPG-pyrophosphorylase in native and transgenic potato plants. To elucidate the mechanism controlling AGP expression during plant development, the expression of the potato tuber AGP small subunit (sAGP) gene was analyzed in transgenic potato plants using a promoter-{beta}-glucuronidase expression system. Part II evaluated the structure-function relationships of AGP.

Okita, T.W.

1999-04-01T23:59:59.000Z

497

Expression of Candidate Genes for Horn Growth in Early Bovine Development  

E-Print Network [OSTI]

, suggesting that each of these genes has a role in intramembranous bone formation. In addition, gradients of expressed C21orf66 and SFRS15 were detected in developing endochondral bone. There was evidence of an antisense transcript of C21orf66 expressed... Page 4.14 Model of the role of genes from the polled interval in intramembranous bone formation...........................................................................................61 xii LIST OF TABLES TABLE...

Vitanza, Sarah M.

2011-02-22T23:59:59.000Z

498

Physiological Ageing as it is Related to Gene Function in the Lone Star Tick, Amblyomma americanum  

E-Print Network [OSTI]

............................ 15 Figure 4 Electrophoresis gel results for the expression of the 16S gene in Amblyomma americanum subdivided by the mortality percentile to the right of the result, the sample number over the top of the result, and the group... as assessed by Image J software displaying the expression of Amblyomma americaum gene 16S for the female control (FC), male control (MC), female experimental (FE), and male experimental (ME) groups from Day 0 to Day 77...

Catena, Amanda M.

2010-07-14T23:59:59.000Z

499

Genetic evaluation of the ovine and bovine prion protein genes (PRNP)  

E-Print Network [OSTI]

GENETIC EVALUATION OF THE OVINE AND BOVINE PRION PROTEIN GENES (PRNP) A Dissertation by CHRISTOPHER MARK SEABURY Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of DOCTOR OF PHILOSOPHY December 2004 Major Subject: Genetics GENETIC EVALUATION OF THE OVINE AND BOVINE PRION PROTEIN GENES (PRNP) A Dissertation by CHRISTOPHER MARK SEABURY Submitted to Texas A&M...

Seabury, Christopher Mark

2006-04-12T23:59:59.000Z

500

The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase  

SciTech Connect (OSTI)

Research highlights: {yields} Utx increases expression of Rb and Rbl2 genes through its demethylase activity. {yields} Utx changes histone H3 methylation on the Rb and Rbl2 promoters. {yields} Utx induces decreased cell proliferation of mammalian primary cells. -- Abstract: Utx is a candidate tumor suppressor gene that encodes histone H3 lysine 27 (H3K27) demethylase. In this study, we found that ectopic expression of Utx enhanced the expression of retinoblastoma tumor suppressor gene Rb and its related gene Rbl2. This activation was dependent on the demethylase activity of Utx, and was suggested to contribute to the decreased cell proliferation induced by Utx. A chromatin immunoprecipitation assay showed that over-expressed Utx was associated with the promoter regions of Rb and Rbl2 resulting in the removal of repressive H3K27 tri-methylation and the increase in active H3K4 tri-methylation. Furthermore, siRNA-mediated knockdown of Utx revealed the recruitment of endogenous Utx protein on the promoters of Rb and Rbl2 genes. These results indicate that Rb and Rbl2 are downstream target genes of Utx and may play important roles in Utx-mediated cell growth control.

Terashima, Minoru; Ishimura, Akihiko; Yoshida, Masakazu [Division of Functional Genomics, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa (Japan)] [Division of Functional Genomics, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa (Japan); Suzuki, Yutaka; Sugano, Sumio [Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8561, Chiba (Japan)] [Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8561, Chiba (Japan); Suzuki, Takeshi, E-mail: suzuki-t@staff.kanazawa-u.ac.jp [Division of Functional Genomics, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa (Japan)] [Division of Functional Genomics, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa (Japan)

2010-08-20T23:59:59.000Z